EUCALYPYOL = 1,8 CINEOLE
Eucalyptol is naturally produced cyclic ether and monoterpenoid.
Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant.
Eucalyptol is an effective treatment for nonpurulent rhinosinusitis.
CAS Number: 470-82-6
EC Number: 207-431-5
Chemical Formula: C10H18O
Molar Mass: 154.249 g/mol
Eucalyptol is a type of monoterpenoid.
Eucalyptol occurs as a colorless liquid that exists as a bicyclic ether.
Eucalyptol also has a fresh, mint-like smell and a spicy-cooling taste.
Eucalyptol is insoluble in water.
However, Eucalyptol is miscible with organic solvents.
Typically, Eucalyptus makes up about 90% of the eucalyptus oil.
Moreover, eucalyptol forms crystalline adducts along with hydrohalic acid, o-cresol, resorcinol, phosphoric acid, etc.
The formation of these adducts is very important in purification.
The chemical formula of this compound is C10H18O.
Eucalyptol molar mass is 154.249 g/mol.
The density of this liquid is closely similar to that of water, and Eucalyptol has a low melting point, which is about 2.9 degrees Celsius.
But Eucalyptol boiling point is comparatively high, which is around 177 degrees Celsius.
Eucalyptol has a pleasant, spicy aroma and taste, and we can use Eucalyptol for flavoring, fragrance, and cosmetics.
We can use Eucalyptol oily form sparingly in different products such as baked goods, confectionery, meat products, and beverages.
Moreover, eucalyptol is an ingredient in commercially available mouthwashes, and Eucalyptol is useful in traditional medicine as a cough suppressant.
1,8-Cineole also known as Eucalyptol, belongs to the class of organic compounds known as oxanes.
Oxanes are compounds containing an oxane (tetrahydropyran) ring, which is a six-membered saturated aliphatic heterocycle, composed of one oxygen atom and five carbon atoms.
Eucalyptol is an organic compound that is a colourless liquid.
Eucalyptol is a cyclic ether and a monoterpenoid.
Monoterpenoids are terpenes that contain 10 carbon atoms and are comprised of two isoprene units.
The biosynthesis of monoterpenes is known to occur mainly through the methyl-eritritol-phosphate (MEP) pathway in the plastids.
Geranyl diphosphate (GPP) is a key intermediate in the biosynthesis of cyclic monoterpenes.
GPP undergoes several cyclization reactions to yield a diverse number of cyclic arrangements.
Eucalyptol is a natural constituent of a number of aromatic plants and their essential oil fractions.
Eucalyptus oil is the oil extracted from the leaves of various Eucalyptus species.
Eucalyptol oil is used for Eucalyptol aromatic properties and as an ingredient in pharmaceutical and industrial applications.
Cineole-based eucalyptus oil is used as a flavouring at low levels (0.002%) in various products, including baked goods, confectionery, meat products, and beverages.
Eucalyptol was given GRAS (Generally Recognized as Safe) status by the Flavor and Extract Manufacturer's Association FEMA in 1965 and is approved by the Food and Drug Administration for food use.
1,8-Dihydroxy-10-carboxy-p-menthane, 2-hydroxy-cineole, and 3-hydroxy-cineole are the main metabolites of eucalyptol.
Toxicological data available on eucalyptol is rather limited.
Following accidental exposure, death was reported in two cases after ingestion of 3.5-5 mL of essential eucalyptus oil, but a number of recoveries have also been described for much higher amounts of oil.
In a 1994 report released by five top cigarette companies, eucalyptol was listed as one of the 599 additives to cigarettes.
Eucalyptol is added to improve the flavour.
Eucalyptol is found in many foods, some of which are common thyme, caraway, sunflower, and pot marjoram.
Eucalyptol is an aromatic chemical, usually appearing as a clear liquid with a herbal eucalyptus odour.
Eucalyptol is naturally present as an organic compound in the essential oils of many plants, including tea tree, rosemary and sage.
Eucalyptol is the chief component of eucalyptus (Eucalyptus globulus) oil, and is used as a component of many fragrances, food and medicine flavourings for Eucalyptol potent aroma and minty-cooling flavour.
Eucalyptol is naturally present as a component of many of the essential oils we use as fragrances for our products.
Eucalyptol, commonly called cineole, is the primary terpene found in eucalyptus and this terpene got Eucalyptol name through eucalyptus.
More than 80% eucalyptol is present in the essential oil extracted from eucalyptus trees.
A good quantity of eucalyptol is present in tea trees, mugwort, bay leaves and cannabis.
The formula for eucalyptol is C10H18O and Eucalyptol can be topically applied to the body.
When compared to the other commonly found terpenes, eucalyptol has more conditions and features.
Eucalyptol can be directly applied on the skin, gums and other areas.
Eucalpytol can be orally inhaled, eaten or consumed as a tincture.
Like any other chemicals eucalyptol is toxic and dangerous when taken in higher dose, so Eucalyptol is always better to dilute the strength of the oil.
Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.
Eucalyptol reduces inflammation and pain when applied topically.
Eucalyptol is a monoterpenoid.
A colorless liquid, Eucalyptol is a bicyclic ether.
Eucalyptol has a fresh mint-like smell and a spicy, cooling taste.
Eucalyptol is insoluble in water, but miscible with organic solvents.
Eucalyptol makes up ~70–90% of eucalyptus oil.
Eucalyptol forms crystalline adducts with hydrohalic acids, o-cresol, resorcinol, and phosphoric acid.
Formation of these adducts is useful for purification.
In 1870, F. S. Cloez identified and ascribed the name "eucalyptol" to the dominant portion of Eucalyptus globulus oil.
Eucalyptol is also known by some other names such as: cineol, cineole, 1,8-cineol, 1,8-cineole, 1,8-epoxy-p-menthan, 1,8-oxido-p-menthan, limonenoxide, cajeputol, eucalyptole, 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane.
This is an active liquid, colorless at room temperature, Eucalyptol is found in nature.
In the essential oil of products with the common name eucalyptus oil, this active ingredient accounts for more than 90%.
That's why many people call Eucalyptol eucalyptus oil.
Eucalyptol is naturally produced cyclic ether and monoterpenoid.
Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant.
Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.
Eucalyptol is an effective treatment for nonpurulent rhinosinusitis.
Eucalyptol reduces inflammation and pain when applied topically.
Eucalyptol kills leukaemia cells in vitro.
Eucalyptol is a natural product found in Curcuma amada, Thryptomene saxicola, and other organisms with data available.
1,8-cineol is a colorless liquid with a camphor-like odor.
Eucalyptol, also frequently called 1,8-cineol, is the primary constituent of oil produced by Eucalyptus spp.
Eucalyptol is also found in tea tree (Melaleuca alternifolia) oil, Artemisia spp. (e.g., wormwood and sagebrush), and even Cannabis sativa.
French chemist François Stanislas Cloez isolated eucalyptol from Eucalyptus globulus in 1870.
Another Eucalyptusspecies, E. cloeziana, was named in his honor.
Because Eucalyptol’s Thanksgiving week, you might have guessed that eucalyptol has something to do with the holiday.
If so, you’d be right.
In addition to the species mentioned above, eucalyptol is an ingredient in many spices used to prepare the turkey day meal: bay leaf, cardamom, rosemary, and sage, to name a few.
Eucalyptol is a contributor to the wonderful aroma of holiday cooking.
Eucalyptol is also used as a flavor ingredient in oral hygiene products and cough suppressants.
Eucalyptol is safe to ingest in small quantities, but Eucalyptol is toxic in larger doses.
In 1981, M. Verma and C. E. Meloan found that eucalyptol in bay leaves is an effective cockroach repellent.
Patients with chronic diseases such as cardiovascular diseases, chronic respiratory diseases, and neurological diseases have been shown to benefit from treatments such as aromatherapy in addition to medication.
Most chronic diseases are caused by chronic inflammation and oxidative stress as well as harmful factors.
Eucalyptol (1,8-cineole), a terpenoid oxide isolated from Eucalyptus species, is a promising compound for treating such conditions as Eucalyptol has been shown to have anti-inflammatory and antioxidant effects in various diseases, including respiratory disease, pancreatitis, colon damage, and cardiovascular and neurodegenerative diseases.
Eucalyptol suppresses lipopolysaccharide (LPS)-induced proinflammatory cytokine production through the action of NF-κB, TNF-α, IL-1β, and IL-6 and the extracellular signal-regulated kinase (ERK) pathway, and reduces oxidative stress through the regulation of signaling pathways and radical scavenging.
The effects of eucalyptol have been studied in several cell and animal models as well as in patients with chronic diseases.
Furthermore, eucalyptol can pass the blood-brain barrier and hence can be used as a carrier to deliver drugs to the brain via a microemulsion system.
In summary, the various biological activities of eucalyptol such as Eucalyptol anti-inflammatory and antioxidant properties, as well as Eucalyptol physicochemical characteristics, make this compound a potentially important drug for the treatment of chronic diseases.
Eucalyptol is widely distributed in plants.
The main food sources are eucalyptus oil (up to 80% eucalyptol), the herbs and spices mugwort, sweet basil, rosemary, sage and cardamom and their essential oils.
Highest exposure from food is likely to arise from hard (cough) candy in which up to about 130 mg eucalyptol/kg or about 2000 mg eucalyptus oil/kg have been reported to be used.
Consumption of 10 g of hard candy containing 2000 mg eucalyptus oil/kg would result in an intake of up to 16 mg of eucalyptol, equivalent to 0.27 mg/kg bw for an adult of 60 kg.
A mean daily intake of eucalyptol from flavoured foodstuffs in France has been estimated to be 4.5 mg/person, equivalent to 0.075 mg/kg bw.
This exercise was based on use levels of eucalyptol provided by industry and took into account the market share of all food categories possibly flavoured by plants, extracts of plants or eucalyptus oil.
The food intake data were from the French survey on individual consumptions.
Uses of Eucalyptol:
In the field of medicine, Eucalyptol is used to make mouthwash and cough medicine.
Eucalyptol has an antiseptic effect on the respiratory tract.
Helps relieve sore throat, itchy throat effectively.
Eucalyptol is used as a flavoring and flavoring agent in cosmetics, confectionery and food.
Due to Eucalyptol pleasant aroma and taste.
In addition, people also use Eucalyptol to make insect repellent.
Eucalyptol is chief constituent of oil of eucalyptus.
Eucalyptol is used in pharmaceuticals (cough syrups and expectorants).
Eucalyptol also used as a flavoring agent, fragrance, disinfectant, and solvent.
Eucalyptus oil contains up to 70% eucalyptol.
Eucalyptol is fragrance and flavoring agent in foods, candies, cough drops, personal car products.
Eucalyptol is used pharmaceuticals (cough syrups, expectorants), flavoring, perfumery
Essential oils such as eucalyptol reduce plaque-related gingivitis.
Because of Eucalyptol pleasant, spicy aroma and taste, eucalyptol is used in flavorings, fragrances, and cosmetics.
Cineole-based eucalyptus oil is used as a flavouring at low levels (0.002%) in various products, including baked goods, confectionery, meat products, and beverages.
In a 1994 report released by five top cigarette companies, eucalyptol was listed as one of the 599 additives to cigarettes.
Eucalyptol is claimed to be added to improve the flavor.
Eucalyptol is an ingredient in commercial mouthwashes, and has been used in traditional medicine as a cough suppressant.
Therapeutic Uses:
Eucalyptol has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis.
Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Eucalyptol.
As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate.
Over a period of 10 days, all patients were administered 3 x 200 mg of Eucalyptol, or a respective placebo, per day.
The primary outcome measure was a Bronchitis Sum Score, which summarizes the relevant symptoms of acute bronchitis.
After 4 days of treatment Eucalyptol was notable, that the patient group treated with Eucalyptol, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group.
The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p?=?0.0001 after 4 days.
The effects of Eucalyptol in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days.
This study corroborates the fact that Eucalyptol actively and significantly reduces cough frequency after four days.
The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease (COPD) are discussed controversially.
Eucalyptol is the main constituent of eucalyptus oil and mainly used in inflammatory airway diseases as a mucolytic agent.
We hypothesized that Eucalyptol known mucolytic, bronchodilating and anti-inflammatory effects as concomitant therapy would reduce the exacerbation rate and show benefits on pulmonary function tests as well as quality of life in patients with COPD.
In this double-blind, placebo-controlled multi-center-study we randomly assigned 242 patients with stable COPD to receive 200 mg of Eucalyptol or placebo 3 times daily as concomitant therapy for 6 months during winter-time.
The frequency, duration and severity of exacerbations were combined as primary outcome measures for testing as multiple criteria.
Secondary outcome measures included changes of lung function, respiratory symptoms and quality of life as well as the single parameters of the exacerbations.
Baseline demographics, lung function and standard medication of both groups were comparable.
During the treatment period of 6 months the multiple criteria frequency, severity and duration of exacerbations were significantly lower in the group treated with Eucalyptol in comparison to placebo.
Secondary outcome measures validated these findings.
Improvement of lung function, dyspnea and quality of life as multiple criteria were statistically significant relative to placebo.
Adverse events were comparable in both groups.
Concomitant therapy with Eucalyptol reduces exacerbations as well as dyspnea and improves lung function and health status.
This study further suggests Eucalyptol as an active controller of airway inflammation in COPD by intervening in the pathophysiology of airway inflammation of the mucus membrane.
Industry Uses:
Flavoring and nutrient
Fragrance
Consumer Uses:
Fragrance
Other Uses:
Eucalyptol exhibits insecticidal and insect repellent properties.
In contrast, eucalyptol is one of many compounds that are attractive to males of various species of orchid bees, which gather the chemical to synthesize pheromones.
Eucalyptol is commonly used as bait to attract and collect these bees for study.
One such study with Euglossa imperialis, a nonsocial orchid bee species, has shown that the presence of cineole (also eucalyptol) elevates territorial behavior and specifically attracts the male bees.
Eucalyptol was even observed that these males would periodically leave their territories to forage for chemicals such as cineole, thought to be important for attracting and mating with females, to synthesize pheromones.
Dosage and Administration of Eucalyptol:
For adults:
Oral medicine:
Adults and children 12 years of age and older take 1 tablet/time: 2 to 4 tablets a day or as directed by a physician.
Spray:
Open the protective cap vertically.
Then put your index finger on the nozzle tip, press 2-3 times in the air to break the inner protective film of the nozzle.
Gently insert the nozzle into the side of the nose.
Then quickly press the nozzle 2-3 times in each nostril.
Clean and dry the nozzle, then close the protective cap.
Note, do not use the medicine more than 4 weeks after opening.
Essential Oils:
Sprinkle a few drops on a handkerchief and inhale as required.
Inhale the vapors from the spilled oil droplets into the bowl of hot water 'inhale' and the moisture is inhaled.
Add 2-3 drops of oil to a cup of warm water (50 ° C) and drink while still warm, use 2 times a day.
Nasal spray:
Pour one teaspoon of medicine into a cup or glass of hot water 70 degrees C-80 degrees C cover the mouth of the cup or glass with a paper funnel.
Place the nose in the funnel.
Then carefully inhale the steam through your nose slowly and slowly while the water is still hot.
Continue to inhale until the vapor is gone.
3 times a day, 1 teaspoon of medicine each time.
Massage oil:
Massage the skin at the painful spot.
Cough in the chest:
Rub in front of the chest, neck, and back.
Indigestion, abdominal pain:
Rub the abdomen Cold and flu (you can put 5-10 drops of oil in 250 mL of hot water in a steamer and inhaler), runny nose, stuffy nose: Rub the temples, neck, back of the neck, nose.
Dizziness, headache, nausea:
Rub both temples, neck, philtrum, nose. For children The dosage form is not suitable for use in children under 12 years of age.
Do not use the inhaler in children under 6 years of age, children with a history of seizures or convulsions due to high fever.
Indications and contraindications of Eucalyptol:
Indications:
Eucalyptol is indicated for the treatment of some of the following cases:
Relieves some symptoms of nasal congestion, rhinitis, and common cold.
Use antiseptic for respiratory tract, teeth, mouth.
Treats runny nose, flu, cough, sore throat, helps relieve symptoms of mild muscle sprains and cramps.
Contraindications:
Eucalyptol is contraindicated in some of the following cases:
Children under 30 months of age or children with seizures due to high fever or a history of seizures.
Do not use in cases of hypersensitivity to any ingredient of the drug.
Eucalyptol should not be used in cases of cough due to asthma and when the patient has respiratory failure (due to the respiratory-suppressive properties of Eucalyptol).
Benefits of Eucalyptol:
Eucalyptol is an analgesic, antibacterial, relieves pain.
Eucalyptol acts as a good anti-fungal and reduces inflammation in systematic manner.
Eucalyptol slows down the growth of cancer cells in the human body and prevents problems of oxidation to other molecules in the body.
Eucalyptol is a colourless natural organic compound and is an ingredient in many brands of mouthwash and cough suppressant.
Eucalyptol is often taken to control mucus hyper secretion and asthma.
Eucalyptol has the power to kill leukaemia cells in vitro and can reduce inflammation when applied externally.
Eucalyptol is used for effective treatment of non-purulent sinusitis and widely used world over.
For Aromatherapy:
Eucalyptol is used in aromatherapy with a combination of eucalyptus oil, lavender, marjoram, rosemary and peppermint oils to reduce pain and depression in people with arthritis.
Chewing gum with eucalyptol present in Eucalyptol can reduce dental plaque in some people.
Eucalyptol is widely used from ancient times for stuffy nose, wounds, ulcers, burns, bleeding gums, acne, bladder diseases, fever, flu, and many more.
Eucalyptol is present in large amounts in a variety of plants used in the manufacture of cosmetics and similar products.
Eucalyptol can enhance blood circulation in human body and Eucalyptol produces cytokines and prostaglandins by stimulated monocytes in vitro.
Higher dose of Eucalyptol by inhalation through nose may result in irritation, nausea and vomiting.
List of plants that contain Eucalyptol:
Aframomum corrorima
Artemisia tridentata
Cannabis
Cinnamomum camphora, camphor laurel (50%)
Eucalyptus cneorifolia
Eucalyptus dives
Eucalyptus dumosa
Eucalyptus globulus
Eucalyptus goniocalyx
Eucalyptus horistes
Eucalyptus kochii
Eucalyptus leucoxylon
Eucalyptus largiflorens
Eucalyptus oleosa
Eucalyptus polybractea
Eucalyptus radiata
Eucalyptus rossii
Eucalyptus salmonophloia
Eucalyptus sideroxylon
Eucalyptus smithii
Eucalyptus staigeriana
Eucalyptus tereticornis
Eucalyptus viridis
Eucalyptus wandoo
Hedychium coronarium, butterfly lily
Helichrysum gymnocephalum
Kaempferia galanga, galangal, (5.7%)
Laurus nobilis, bay laurel, (45%)
Melaleuca alternifolia, tea tree, (0–15%)
Salvia lavandulifolia, Spanish sage (13%)
Turnera diffusa, damiana
Umbellularia californica, pepperwood (22.0%)
Zingiber officinale, ginger
Manufacturing Methods of Eucalyptol:
Eucalyptol is obtained from essential oils containing high levels of eucalyptol, such as Eucalyptus globulus (about 60%), by fractional distillation (170-180 °C) followed by separation of the product by solidification of the distillate.
By fractionally distilling eucalyptus oil followed by freezing.
The oil is imported from Spain, Portugal, and Austria.
1,8-Cineole is extracted exclusively from eucalyptus oils with a high 1,8-cineole content.
Various processes are used to separate Eucalyptol from the other terpenes, for example, treatment with H2SO4 in the cold, distillation in the presence of phenols, such as cresols or resorcinol, which form loose addition compounds, or by addition to beta-naphthol.
1,8-Cineole can also be enriched by rectification.
The yield is increased by gasification in the presence of a chromium-nickel catalyst.
Technical-grade 1,8-cineole with a purity of 99.6 - 99.8% is produced in Spain in large quantities by fractional distillation of Eucalyptus globulus Labill.
A product essentially free from other products can be obtained by crystallization of cineole-rich eucalyptus oil fractions.
General Manufacturing Information of Eucalyptol:
Industry Processing Sectors:
All Other Basic Organic Chemical Manufacturing
All Other Chemical Product and Preparation Manufacturing
Food, beverage, and tobacco product manufacturing
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
1,8-cineole is produced only from natural sources as these are sufficiently inexpensive to make synthesis uneconomic.
Originally, Eucalyptol was produced from Cajeput oil, but the discovery of Eucalyptus globulus, the oil of which contains up to 95% 1,8-cineole, in 1788 led to the first commercial production from that source in 1854 in Australia, and then to Eucalyptols taking over as the dominant source.
Much of the oil is used per se and only about one-quarter of Eucalyptol is distilled to produce pure cineole.
The chief constituent of oil of eucalyptus; also found in essential oils of laurel, rosemary, and many other aromatic plants.
Handling and Storage of Eucalyptol:
Nonfire Spill Response:
SMALL SPILLS AND LEAKAGE:
If you spill this chemical, use absorbent paper to pick up all liquid spill material.
Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution.
Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures and away from mineral acids and bases.
Storage Conditions:
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature -20 °C.
First Aid Measures of Eucalyptol:
EYES:
First check the victim for contact lenses and remove if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN:
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area.
Take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
If not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.
Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.
DO NOT INDUCE VOMITING.
IMMEDIATELY transport the victim to a hospital.
Precautions when using Eucalyptol:
If the cough does not improve after being treated with the usual dose, do not increase the dose on your own.
Do not apply to eyes or open wounds.
Use with caution in patients with asthma and respiratory failure.
Ointment form:
Discontinue use as soon as burns or blisters appear.
Keep the medicine out of reach of children Never use the medicine after the expiry date or discolouration.
Caution should be exercised when administering the drug to women during pregnancy or lactation.
For medicines or supplements containing Eucalyptol, if you miss a dose, try to take Eucalyptol again as soon as possible.
However, if Eucalyptol is almost time for your next dose, take your next dose as usual.
Absolutely do not arbitrarily double the dose as directed.
With the diverse effects of the drug Eucalyptol, when using Eucalyptol, you need to be very careful to use Eucalyptol correctly to avoid possible unwanted side effects.
Please consult with your doctor to get the dose and method of use that is best for your condition.
Fire Fighting of Eucalyptol:
Fires involving this compound should be controlled with a dry chemical, carbon dioxide, foam or Halon extinguisher.
Fire Fighting Procedures of Eucalyptol:
Advice for firefighters; Wear self-contained breathing apparatus for firefighting if necessary.
Use water spray to cool unopened containers.
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Isolation and Evacuation of Eucalyptol:
As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.
LARGE SPILL:
Consider initial downwind evacuation for at least 300 meters (1000 feet).
FIRE:
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Cleanup Methods of Eucalyptol:
Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapors, mist or gas.
Remove all sources of ignition.
Beware of vapors accumulating to form explosive concentrations.
Vapors can accumulate in low areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Methods and materials for containment and cleaning up:
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
Disposal Methods of Eucalyptol:
Recycle any unused portion of the material for Eucalyptol approved use or return Eucalyptol to the manufacturer or supplier.
Ultimate disposal of the chemical must consider:
The material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations.
If Eucalyptol is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
Preventive Measures of Eucalyptol:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Identifiers of Eucalyptol:
CAS Number: 470-82-6
Beilstein Reference: 105109 5239941
ChEBI: CHEBI:27961
ChEMBL: ChEMBL485259
ChemSpider: 2656
DrugBank: DB03852
ECHA InfoCard: 100.006.757
EC Number: 207-431-5
Gmelin Reference: 131076
IUPHAR/BPS: 2464
KEGG: D04115
PubChem CID: 2758
UNII: RV6J6604TK
CompTox Dashboard (EPA): DTXSID4020616
InChI:
InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3
Key: WEEGYLXZBRQIMU-UHFFFAOYSA-N
InChI=1/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3
Key: WEEGYLXZBRQIMU-UHFFFAOYAY
SMILES: O2C1(CCC(CC1)C2(C)C)C
CAS Number: 470-82-6
Chem/IUPAC Name: 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane; 1,8-Cineole
EINECS/ELINCS No: 207-431-5
COSING REF No: 33902
Formal Name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
CAS Number: 470-82-6
Synonyms: NSC 6171
Molecular Formula: C10H18O
Formula Weight: 154.3
Purity: ≥98%
Formulation (Request formulation change): A neat oil
Solubility (Learn about Variance in Solubility):
DMF: 20 mg/ml
DMSO: 20 mg/ml
DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
Ethanol: 20 mg/ml
SMILES: CC12CCC(CC2)C(C)(C)O1
InChi Code: InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3
InChi Key: WEEGYLXZBRQIMU-UHFFFAOYSA-N
Synonym(s): 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-Cineole, 1,8-Epoxy-p-menthane
Empirical Formula (Hill Notation): C10H18O
CAS Number: 470-82-6
Molecular Weight: 154.25
Beilstein: 105109
EC Number: 207-431-5
MDL number: MFCD00167977
PubChem Substance ID: 24893017
NACRES: NA.22
Properties of Eucalyptol:
Chemical formula: C10H18O
Molar mass: 154.249 g/mol
Density: 0.9225 g/cm3
Melting point: 2.9 °C (37.2 °F; 276.0 K)
Boiling point: 176–177 °C (349–351 °F; 449–450 K)
Magnetic susceptibility (χ): −116.3×10−6 cm3/mol
Quality Level: 200
Assay: 99%
Form: liquid
Refractive index: n20/D 1.457 (lit.)
bp: 176-177 °C (lit.)
mp: 1-2 °C (lit.)
Density: 0.921 g/mL at 25 °C (lit.)
Greener alternative category: Aligned
SMILES string: C[C@]12CC[C@H](CC1)C(C)(C)O2
InChI: 1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3/t8-,10+
InChI key: WEEGYLXZBRQIMU-WAAGHKOSSA-N
Name: Eucalyptol
Chemical Name: 1,8-Cineol
Chemical Formula: C10H18O
Appearance: Liquid with A Characteristic
Molecular Weight:
Odour: Light Camphor like odour
Specific gravity: 0.921 to 0.925 at 250C
GLC Purity: Approx 99%
Refractive Index: 1.455 to 1.460 at 200C
Colour: colourless to pale yellow
Molecular Weight: 154.25
XLogP3: 2.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 154.135765193
Monoisotopic Mass: 154.135765193
Topological Polar Surface Area: 9.2 Ų
Heavy Atom Count: 11
Complexity: 164
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Specifications of Eucalyptol:
Appearance: Colorless to yellowish oily transparent liquid
Odor: Having characteristic odor of camphor, with an intense pungent cool taste
Relative Density (25/25°C): 0.9210 ~ 0.9300
Refractive Index (20°C): 1.4540 ~ 1.4610
Names of Eucalyptol:
IUPAC name:
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane
Other names:
1,8-Cineole
1,8-Epoxy-p-menthane
cajeputol
1,8-epoxy-p-menthane, 1,8-oxido-p-menthane
eucalyptole
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
cineol
cineole.
Synonyms of Eucalyptol:
Eucalyptol
cineole
1,8-Cineole
470-82-6
1,8-Cineol
Cajeputol
1,8-Epoxy-p-menthane
Eucalyptole
Eucapur
Zineol
Terpan
p-Cineole
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane
Eukalyptol
1,8-Oxido-p-menthane
CINEOL
Cucalyptol
Soledum
p-Menthane, 1,8-epoxy-
Eukalyptol [Czech]
Eucalyptol (natural)
FEMA No. 2465
2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-
8000-48-4
Cineole (VAN)
NCI-C56575
2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-
Eucaly
1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane
2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane
NSC 6171
NSC-6171
NSC6171
2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane
2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane
RV6J6604TK
CNL
4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane
CHEBI:27961
Eucalyptol [USAN]
NCGC00091666-01
NCGC00091666-04
(1s,4s)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
Eucalyptol 1000 microg/mL in Methanol
UNII-RV6J6604TK
CAS-470-82-6
SMR000471853
CCRIS 3727
HSDB 991
Eucalyptol [USAN:USP]
EINECS 207-431-5
MFCD00167977
Terpane
Cyneol
BIDD:ER0481
AI3-00578
Eucalyptol,(S)
Eucalyptol (USP)
1.8-cineole
Eucalyptol, 99%
Eucalyptol, Ph Helv
p-Menthane,8-epoxy-
EUCALYPTOL [II]
EUCALYPTOL [MI]
WLN: T66 A B AOTJ B1 B1 F1
CINEOLE [INCI]
EUCALYPTOL [FCC]
1,8-Cineol-[d3]
CINEOLE [MART.]
Spectrum2_000221
Spectrum3_000683
Spectrum4_001747
Spectrum5_000704
EUCALYPTOL [FHFI]
EUCALYPTOL [HPUS]
EUCALYPTOL [HSDB]
EUCALYPTOL [INCI]
CINEOLE [WHO-DD]
EUCALYPTOL [VANDF]
bmse000523
EC 207-431-5
EUCALYPTOL [USP-RS]
SCHEMBL19622
SCHEMBL41020
BSPBio_002405
KBioGR_002194
MLS001050089
MLS001066338
DivK1c_000333
SPECTRUM1500294
SPBio_000261
CINEOLE [EP MONOGRAPH]
Eucalyptol, analytical standard
CHEMBL485259
GTPL2464
CHEMBL1231862
CHEMBL1397305
DTXSID4020616
SCHEMBL13554591
SCHEMBL17836873
HMS501A15
KBio1_000333
KBio3_001625
EUCALYPTOL [USP IMPURITY]
NINDS_000333
EUCALYPTOL [USP MONOGRAPH]
HMS2271P04
Pharmakon1600-01500294
ZINC967566
HY-N0066
Tox21_111161
Tox21_202090
Tox21_302902
BDBM50459887
CCG-36080
NSC760388
AKOS015903223
AKOS016034339
AKOS037514637
Tox21_111161_1
CCG-266254
CS-8146
DB03852
LMPR0102090019
NSC-760388
IDI1_000333
Eucalyptol, tested according to Ph.Eur.
NCGC00091666-02
NCGC00091666-03
NCGC00091666-05
NCGC00095774-01
NCGC00178671-01
NCGC00256479-01
NCGC00259639-01
AC-20234
Eucalyptol, natural, >=99%, FCC, FG
LS-13868
NCI60_005108
1,3-Trimethyl-2-oxabicyclo[2.2.2]octane
2-Oxa-1,3-trimethylbicyclo[2.2.2]octane
DB-070775
2-Oxabicyclo[2.2.2]octane,3,3-trimethyl-
FT-0607033
FT-0626369
1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane
A15662
C09844
D04115
AB01563262_01
Q161572
SR-01000763816
SR-01000763816-2
W-106080
1,8-Cineole, primary pharmaceutical reference standard
Cineole, European Pharmacopoeia (EP) Reference Standard
Eucalyptol, certified reference material, TraceCERT(R)
F0001-1260
Eucalyptol, United States Pharmacopeia (USP) Reference Standard
Eucalyptol (cineole), Pharmaceutical Secondary Standard; Certified Reference Material
(±)-Eucalyptol
1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octan [German] [ACD/IUPAC Name]
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane [ACD/IUPAC Name]
1,3,3-Triméthyl-2-oxabicyclo[2.2.2]octane [French] [ACD/IUPAC Name]
1,8-Cineol
1,8-cineole
207-431-5 [EINECS]
2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane
2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl- [ACD/Index Name]
470-82-6 [RN]
Eucalyptol [USAN]
Eucalyptole
Eukalyptol [Czech]
Eukalyptol [Czech]
p-Cineole
p-Menthane, 1,8-epoxy-
1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane
1,8-epoxy-p-menthane
1,8-oxido-p-menthane
105109
1216822-66-0 [RN]
2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane
2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane
2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-
4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane
cajeputol
Cineole
CNL
Eucapur
Eukalyptol
Limonene oxide
MFCD00167977 [MDL number]
T66 A B AOTJ B1 B1 F1 [WLN]
Terpan
Zineol
MeSH Entry Terms of Eucalyptol:
1,8 Cineol
1,8 Cineole
1,8 Epoxy p menthane
1,8-cineol
1,8-cineole
1,8-Epoxy-p-menthane
cineole
eucalyptol
Soledum
