Ethyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid.
Ethyl Acetate has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes.
Ethyl Acetate is one of the simplest carboxylate esters.

CAS Number: 141-78-6
Molecular Formula: C4H8O2
Molecular Weight: 88.11
EINECS Number: 205-500-4

Ethyl Acetate is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc.
Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.

The colorless liquid has a sweet, fruity odor that most people find pleasant.
Ethyl acetate (systematically, ethyl ethanoate, commonly abbreviated EtOAc or EA) is the organic compound with the formula CH3COOCH2CH3.
This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, decaffeinating tea and coffee, and cigarettes (see list of additives in cigarettes).

Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent.
The combined annual production in 1985 of Japan, North America, and Europe was about 400,000 tons.
In 2004, an estimated 1.3M tons were produced worldwide.

Ethyl acetate (systematically ethyl ethanoate, commonly abbreviated EtOAc, ETAC or EA) is the organic compound with the formula CH3CO2CH2CH3, simplified to C4H8O2.
This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, and in the decaffeination process of tea and coffee.
Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent.

Ethyl acetate is used as a solvent for varnishes, lacquers, dry cleaning, stains, fats and nitrocellulose.
Ethyl Acetate is released during the production of artificial silk and leather, and during the preparation of photographic films and plates.
Ethyl Acetate is released during the manufacture of linoleum, and 'plastic' wood, dyes, pharmaceuticals, drug intermediates, acetic acid, artificial fruit flavorings and essences, and perfumes and fragrances.

Ethyl acetate is used as a solvent in nail polish, nail polish remover, base coats and other manicuring products.
Ethyl acetate is present in wines.
Ethyl acetate is manufactured on a large scale, as over 1 million tons are produced annually in the world.

Ethyl Acetate is used commonly due to its low cost and agreeable aroma.
Ethyl acetate has a pleasant ethereal fruity, brandy-like odor, reminiscent of pineapple, somewhat nauseating in high concentration.
Ethyl Acetate has fruity sweet taste when freshly diluted in water.
Ethyl acetate is probably one of the most used of all flavor chemicals by volume.

Ethyl acetate is slowly decomposed by moisture and then acquires an acid status due to the acetic acid formed.
Ethyl Acetate is the acetate ester formed between acetic acid and ethanol.
Ethyl Acetate has a role as a polar aprotic solvent, an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor, a metabolite and a Saccharomyces cerevisiae metabolite.

Ethyl Acetate is an acetate ester, an ethyl ester and a volatile organic compound.
Ethyl acetate, a carboxylate ester, is bio-friendly organic solvent with wide range of industrial applications.
Its synthesis by reactive distillation and by acceptorless dehydrogenative dimerization of ethanol has been explored.

Ethyl Acetates utility as a less toxic alternative to diethyl ether in the formalin-ether (F-E) sedimentation procedure for intestinal parasites has been investigated.
Ethyl Acetates ability as an acyl acceptor in the immobilized lipase-mediated preparation of biodiesel from crude vegetable oils has been examined.
The complete degradation of ethyl acetate to CO2 using manganese octahedral molecular sieve (OMS-2) has been investigated.

Ethyl acetate (structure shown above) is the most familiar ester to many chemistry students and possibly the ester with the widest range of uses.
Esters are structurally derived from carboxylic acids by replacing the acidic hydrogen by an alkyl or aryl group.
Ethyl acetate itself is a colourless liquid at room temperature with a pleasant "fruity" smell, b.p. 77°C.

Ethyl acetate has many uses, such as artificial fruit essences and aroma enhancers, artificial flavours for confectionery, ice cream and cakes, as a solvent in many applications (including decaffeinating tea and coffee) for varnishes and paints (nail varnish remover), and for the manufacture of printing inks and perfumes.
Ethyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid.
Ethyl Acetate can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation.

Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation.
Ethyl Acetate has a boiling point of 77 °C and purity being over 99%.
Ethyl acetate is the most common ester in wine, being the product of the most common volatile organic acid – acetic acid, and the ethyl alcohol generated during the fermentation.

The aroma of ethyl acetate is most vivid in younger wines and contributes towards the general perception of "fruitiness" in the wine.
Sensitivity varies, with most people having a perception threshold around 120 mg/L.
Excessive amounts of ethyl acetate are considered a wine fault.

Ethyl acetate (also known as ethyl ethanoate, acetic acid ethyl ester, acetoxyethane, 1-acetoxyethane, EtOAC, ETAC, EA) is an organic ester compound with a molecular formula of C4H8O2.
Ethyl Acetate is a colourless liquid with a fruity characteristic odour that is commonly recognised in glues and nail polish remover.
Ethyl acetate is extremely flammable with a flashpoint of -4° C and a flammability rating of 3 and is also highly miscible with all common organic solvents (alcohols, ketones, glycols, esters) but only slightly miscibility in water.

Ethyl Acetate is commonly used as a solvent for cleaning, paint removal and coatings.
The molecular formula of Ethyl Acetate can be easily memorized because as the name suggests it contains ethyl group (CH2-CH3 or C2H5) and acetate group (CH3COO).
Ethyl acetate is an organic compound that is an ester of ethanol and acetic acid.

Ethyl acetate, also known as 1-acetoxyethane or acetic ester, belongs to the class of organic compounds known as carboxylic acid esters.
These are carboxylic acid derivatives in which the carbon atom from the carbonyl group is attached to an alkyl or an aryl moiety through an oxygen atom (forming an ester group).
Ethyl acetate exists in all eukaryotes, ranging from yeast to humans.

Ethyl acetate is a sweet, anise, and balsam tasting compound. Ethyl acetate is found, on average, in the highest concentration within a few different foods, such as milk (cow), pineapples, and sweet oranges and in a lower concentration in safflowers.
Ethyl acetate has also been detected, but not quantified, in several different foods, such as alcoholic beverages, oxheart cabbages, agaves, chervils, ryes, and peach.
Ethyl Acetate is used in artificial fruit essences.

In the field of entomology, ethyl acetate is an effective asphyxiant for use in insect collecting and study.
Because it is not hygroscopic, ethyl acetate also keeps the insect soft enough to allow proper mounting suitable for a collection.
In a killing jar charged with ethyl acetate, the vapors will kill the collected (usually adult) insect quickly without destroying it.

In organic and in natural products chemistry ethyl acetate is often used as a solvent for reactions or extractions.
Ethyl acetate is a potentially toxic compound.
Ethyl acetate, with regard to humans, has been found to be associated with several diseases such as perillyl alcohol administration for cancer treatment, crohn's disease, nonalcoholic fatty liver disease, and pervasive developmental disorder not otherwise specified; ethyl acetate has also been linked to the inborn metabolic disorder celiac disease.

Melting point: −84 °C(lit.)
Boiling point: 76.5-77.5 °C(lit.)
Density: 0.902 g/mL at 25 °C(lit.)
vapor density: 3 (20 °C, vs air)
vapor pressure: 73 mm Hg ( 20 °C)
refractive index: n20/D 1.3720(lit.)
FEMA: 2414 | ETHYL ACETATE
Flash point: 26 °F
storage temp.: Store at +2°C to +25°C.
solubility: Miscible with ethanol, acetone, diethyl ether and benzene.
pka: 16-18(at 25℃)
form: Liquid
Specific Gravity: 0.902 (20/20℃)
color: APHA: ≤10
Relative polarity: 0.228
Odor: Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm)
explosive limit 2.2-11.5%, 38°F
Odor Threshold: 0.87ppm
Odor Type: ethereal
Water Solubility: 80 g/L (20 ºC)
λmax λ: 256 nm Amax: ≤1.00
λ: 275 nm Amax: ≤0.05
λ: 300 nm Amax: ≤0.03
λ: 325-400 nm Amax: ≤0.005
JECFA Number: 27
Merck: 14,3757
BRN: 506104
Henry's Law Constant: 0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005)
Exposure limits TLV-TWA 400 ppm (～1400 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH).
Stability: Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
InChIKey: XEKOWRVHYACXOJ-UHFFFAOYSA-N
LogP: 0.68-0.73 at 20-25℃

Ethyl Acetate is a compound produced by yeast that is quantitatively the major ester found in both beer and wine.
Esters are aromatic compounds formed by the reaction between alcohols and acids.
They are widely found in nature and contribute to the aromas of many varieties of fruit.

Over 90 esters can occur in beer, and the ethyl esters predominate.
These esters contribute to the overall flavor and aroma of beer, giving a “fruity” quality to a drink that rarely contains any fruit.
As ethyl acetate intensifies, however, the aromatic perception can skew from pleasant and “fruity” to “solventy” and “perfumy;” abnormally high levels are therefore regarded as off-flavors.

In addition to being produced by brewer’s yeast strains (Saccharomyces cerevisiae and Saccharomyces pastorianus), ethyl acetate is also produced in large quantities by the wild yeasts Brettanomyces, Hansenula, and Pichia via aerobic fermentation.
Because ethyl acetate is such an influential part of beer aromatics—for good or ill—brewers seek to control its levels in their beers.
Many factors, in addition to the yeast strain employed, have been found to influence the concentration of ethyl acetate formed during fermentation.

These include fermentation temperature, where an increase from 50°F to 77°F (10°C–25°C) has been found to increase the concentration of ethyl acetate from 12.5 to 21.5 mg/L.
Continuous fermentation results in higher levels of esters as compared to conventional batch fermentation.
High yeast pitching rates result in lower levels of ethyl acetate.

Higher gravity worts can result in elevated levels of esters.
Lowering the levels of oxygen supplied to yeast will enhance overall ester formation.
Ethyl acetate arises as a result of the reaction between ethanol and acetyl CoA.

Practical measures can be taken to lower ester levels (particularly in high gravity worts), including the production of wort with a suitably low carbon-to-nitrogen ratio and the supply of adequate oxygen at the outset of fermentation, both of which promote yeast growth.
The application of pressure during fermentation reduces both yeast growth and ester synthesis.

Ethyl acetate is a chemical compound with the formula CH3COOCH2CH3.
Ethyl Acetate is an ester, which is a type of organic compound commonly used in various industrial and laboratory applications.
Ethyl acetate is a colorless liquid with a sweet, fruity odor, making it one of the more pleasant-smelling solvents.

Ethyl acetate is also sensitive to heat.
On prolonged storage, materials containing similar functional groups have formed explosive peroxides.
Ethyl acetate may ignite or explode with lithium aluminum hydride.

Ethyl acetate may also ignite with potassium tert-butoxide.
Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids.
Ethyl acetate will attack some forms of plastics, rubber and coatings.

Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide.
Violent reactions occur with chlorosulfonic acid.
In pharmaceutical preparations, ethyl acetate is primarily used as a solvent, although it has also been used as a flavoring agent.

As a solvent, Ethyl Acetate is included in topical solutions and gels, and in edible printing inks used for tablets.
Ethyl acetate has also been shown to increase the solubility of chlortalidone and to modify the polymorphic crystal forms obtained for piroxicam pivalate, mefenamic acid, and fluconazole,and has been used in the formulation of microspheres.
Ethyl acetate has been used as a solvent in the preparation of a liposomal amphotericin B dry powder inhaler formulation.

Ethyl Acetates use as a chemical enhancer for the transdermal iontophoresis of insulin has been investigated.
In food applications, ethyl acetate is mainly used as a flavoring agent.
Ethyl Acetate is also used in artificial fruit essence and as an extraction solvent in food processing.

Ethyl Acetate is a product with high solvency power and fast evaporation rate.
Ethyl Acetate is widely used in applications such as: Paints and Varnishes, Printing Inks, Adhesives, Thinners and Paint Strippers.

Synthesis of intermediates: active pharmaceutical ingredients and in the preparation of intermediates and active pharmaceutical ingredients of vegetal sources and in the classic biological processes for intermediates and active pharmaceutical ingredients production.
Ethyl Acetate has low toxicity, it is miscible with hydrocarbons, esters, alcohols and ethers, and it has low water solubility The direct use in the processing of medicines and foods is not recommended.


Production Methods
Industrial production of ethyl acetate is mainly classified into three processes.
The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst.
This process needs acid catalyst such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc.

This mixture converts to the ester in about 65% yield at room temperature.
CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst.
In Germany and Japan, most ethyl acetate is produced via the Tishchenko process.
2 CH3CHO → CH3COOC2H5

This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.
The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid as a catalyst.
CH2= CH2 + CH3COOH → CH3COOC2H5

The processes, however, have some disadvantages; both the conventional esterification and addition of Ethyl Acetate to ethylene need stock tanks and apparatus for several feed stocks.
Moreover, they use acetic acid that causes apparatus corrosion.
Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.

In such circumstances, an improved process of ethyl acetate production is strongly desired.
Ethyl acetate is synthesized in industry mainly via the classic Fischer esterification reaction of ethanol and acetic acid. This mixture converts to the ester in about 65% yield at room temperature:
CH3CH2OH + CH3COOH ? CH3COOCH2CH3 + H2O

The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.
Ethyl Acetate is also prepared in industry using the Tishchenko reaction, by combining two equivalents of acetaldehyde in the presence of an alkoxide catalyst:
2 CH3CHO → CH3COOCH2CH3.

Uses
Ethyl acetate is used as a solvent for varnishes, lacquers, and nitrocellulose; as anartificial fruit flavor; in cleaning textiles;and in the manufacture of artificial silk andleather, perfumes, and photographic filmsand plates (Merck 1996).
Ethyl Acetate is generally used as a solvent in organic reactions. Environmental contaminants; Food contaminants.
Ethyl acetate is used primarily as a solvent and diluent, being favored because of its low cost, low toxicity, and agreeable odor.

Ethyl Acetate is commonly used to clean circuit boards and in some nail varnish removers (acetone and acetonitrile are also used).
Coffee beans and tea leaves are decaffeinated with this solvent.
Ethyl Acetate is also used in paints as an activator or hardener.

Ethyl Acetate is present in confectionery, perfumes, and fruits.
In perfumes, Ethyl Acetate evaporates quickly, leaving only the scent of the perfume on the skin.
In the laboratory, mixtures containing ethyl acetate are commonly used in column chromatography and extractions.

Ethyl acetate is rarely selected as a reaction solvent because it is prone to hydrolysis and trans esterification.
Ethyl acetate is the most common ester in wine, being the product of the most common volatile organic acid — acetic acid, and the ethyl alcohol generated during the fermentation.
The aroma of ethyl acetate is most vivid in younger wines and contributes towards the general perception of "fruitiness" in the wine.

In the field of entomology, ethyl acetate is an effective asphyxiant for use in insect collecting and study.
In a killing jar charged with ethyl acetate, the vapors will kill the collected (usually adult) insect quickly without destroying it.
Because it is not hygroscopic, ethyl acetate also keeps the insect soft enough to allow proper mounting suitable for a collection.

Pharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.
Ethyl acetate is used primarily as a solvent and diluent, being favored because of its low cost, low toxicity, and agreeable odor.
Ethyl acetate is commonly used to clean circuit boards and in some nail varnish removers (acetone is also used).

Coffee beans and tea leaves are decaffeinated with this solvent.
Ethyl acetate is also used in paints as an activator or hardener.
Ethyl acetate is present in confectionery, perfumes, and fruits.

In perfumes Ethyl acetate evaporates quickly, leaving the scent of the perfume on the skin.
Ethyl acetate is an asphyxiant for use in insect collecting and study.
In a killing jar charged with ethyl acetate, the vapors will kill the collected insect quickly without destroying it.

Because it is not hygroscopic, ethyl acetate also keeps the insect soft enough to allow proper mounting suitable for a collection.
However, ethyl acetate is regarded as potentially doing damage to insect DNA, making specimens processed this way less than ideal for subsequent DNA sequencing.
In the laboratory, mixtures containing ethyl acetate are commonly used in column chromatography and extractions.

Ethyl acetate is rarely selected as a reaction solvent because it is prone to hydrolysis, transesterification, and condensations.
Ethyl acetate is used in the following products: coating products and laboratory chemicals.
Ethyl acetate has an industrial use resulting in manufacture of another substance (use of intermediates).

Ethyl acetate is used in the following areas: scientific research and development and health services.
Ethyl acetate is used for the manufacture of: chemicals and plastic products.
Release to the environment of Ethyl acetate can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.

Ethyl acetate has many uses, such as artificial fruit essences and aroma enhancers, artificial flavours for confectionery, ice cream and cakes, as a solvent in many applications (including decaffeinating tea and coffee) for varnishes and paints (nail varnish remover), and for the manufacture of printing inks and perfumes.
Ethyl acetate is widely used as a solvent in chemical reactions or preparations.
This is the reason it is manufactured on a large scale.

Ethyl acetate is used primarily as a solvent and diluent.
Ethyl acetate is commonly used to clean the circuit boards, in some nail varnish removers and also in residue, environmental and GC analysis.
Ethyl acetate is used chiefly as a scent in the manufacture of perfumes.

Ethyl acetate is also used in flavorings, glues, in decaffeinating tea and coffee, and in cigarettes.
The other minor applications of ethyl acetate include its applications in the textiles, dyestuffs, explosives, photographic films and plates, artificial leather.
Ethyl acetate is primarily used as a solvent in various applications, such as in the production of paints, varnishes, lacquers, and coatings.

Ethyl acetate is also used in the pharmaceutical and chemical industries as a solvent for various chemicals and reactions.
Ethyl acetate is used in the food industry for extracting flavors and fragrances from natural sources, such as fruits, flowers, and herbs.
Ethyl acetate is often employed in the production of perfumes and essential oils.

Ethyl acetate is a common ingredient in nail polish removers due to its ability to dissolve nail polish effectively.
Ethyl acetate is used in laboratories as a solvent for various chemical reactions and as a mobile phase in chromatography techniques.
Ethyl acetate is found naturally in some fruits, and its aroma is associated with sweet, fruity notes.

Ethyl acetate contributes to the aroma and flavor of certain fruits, including apples and pears.
Ethyl acetate is composed of two main parts—a carbonyl group (C=O) and an alkyl group (CH3CH2O-).
This chemical structure gives it its characteristic properties and reactivity.

Ethyl acetate is primarily used as a solvent in the industrial sector.
Ethyl acetate is employed in the production of paints, varnishes, lacquers, and coatings.
Ethyl acetates ability to dissolve a wide range of substances makes it valuable for these applications.

Ethyl acetate is used in the pharmaceutical industry as a solvent for various drugs and pharmaceutical formulations.
Ethyl acetate can be used in the production of tablets, capsules, and liquid medicines.
Ethyl acetate is a common ingredient in nail polish formulations.

Ethyl acetate helps dissolve and suspend the pigments and provides a smooth application.
Ethyl acetate is also a key component of nail polish removers for effectively removing nail polish from nails.
Ethyl acetate is used in the food industry as a flavoring agent and aroma enhancer.

Ethyl acetate is particularly valuable for extracting natural flavors and fragrances from fruits, flowers, and herbs.
This extraction process is crucial in the production of various food products, perfumes, and essential oils.
In laboratory settings, ethyl acetate is used as a solvent for various chemical reactions and for the purification of organic compounds.

Ethyl acetate is often used in chromatography techniques as a mobile phase.
Ethyl acetate is sometimes used in the formulation of adhesives, including certain types of glues and industrial adhesives.
Ethyl acetate is used in the production of automotive paints, industrial coatings, and wood finishes due to its ability to dissolve and carry pigments and resins.

Ethyl acetate is used in the formulation of cleaning products, such as paint and graffiti removers, due to its effective solvent properties.
In organic chemistry, ethyl acetate can be used as a reagent or solvent in various reactions and processes.
Ethyl acetate is found naturally in some fruits and contributes to their aroma and flavor.

Ethyl acetate is used in the fragrance industry to create fruity and floral scents.
Ethyl acetate is sometimes used by entomologists (scientists who study insects) as a killing agent for collecting and preserving insect specimens.
Ethyl acetate is used in the printing industry as a solvent for inks and as an adhesive for certain types of packaging materials, including laminates and foils.

Ethyl acetate is employed in the textile industry for dyeing and printing fabrics.
Ethyl acetate can be used as a solvent for textile dyes and in the production of textile finishes.
Ethyl acetate can be found in some cosmetics and personal care products, including perfumes, colognes, and hair sprays, where it contributes to the fragrance and formulation.

In addition to its use in the food industry, ethyl acetate is used to make artificial flavorings and extracts for a variety of food and beverage products.
Ethyl acetate is sometimes used in the decaffeination process of coffee and tea.
Ethyl acetate helps remove caffeine from coffee beans or tea leaves while preserving flavor compounds.

In analytical chemistry, ethyl acetate can be used as a solvent for sample preparation in analytical techniques like gas chromatography (GC) and high-performance liquid chromatography (HPLC).
Ethyl acetate is used as a propellant in aerosol sprays, such as those used in spray paints, air fresheners, and personal care products.
Ethyl acetate is used as a carrier solvent for some pesticides and herbicides, aiding in their application to crops and plants.

Ethyl acetate is used in the formulation of paint strippers and paint remover products due to its ability to dissolve paint and coatings.
In certain types of fire extinguishers, ethyl acetate is used as a component of the filler material.

Ethyl acetate is used in the production of synthetic resins, such as cellulose acetate butyrate and polyvinyl acetate, which have applications in plastics, coatings, and adhesives.
Ethyl acetate can be used as a reactant or solvent in various chemical synthesis processes, including the production of pharmaceuticals and fine chemicals.

Safety Profile:
Potentially poisonous by ingestion.
Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant.
Ethyl acetate a flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials.

Moderate explosion hazard.
Ethyl acetate is used in foods, and oral and topical pharmaceutical formulations.
Ethyl acetate is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.

However, ethyl acetate may be irritant to mucous membranes, and high concentrations may cause central nervous system depression.
Potential symptoms of overexposure include irritation of the eyes, nose, and throat, narcosis, and dermatitis.
Ethyl acetate has not been shown to be a human carcinogen or a reproductive or developmental toxin.

Health Hazard
The acute toxicity of ethyl acetate is low.
Ethyl acetate vapor causes eye, skin, and respiratory tract irritation at concentrations above 400 ppm.
Exposure to high concentrations may lead to headache, nausea, blurred vision, central nervous system depression, dizziness, drowsiness, and fatigue.

Ingestion of ethyl acetate may cause gastrointestinal irritation and, with larger amounts, central nervous system depression.
Eye contact with the liquid can produce temporary irritation and lacrimation.
Skin contact produces irritation.

Ethyl acetate is regarded as a substance with good warning properties.
No chronic systemic effects have been reported in humans, and ethyl acetate has not been shown to be a human carcinogen, reproductive, or developmental toxin

Flammability and Explosibility:
Ethyl acetate is a flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back."
Ethyl acetate vapor forms explosive mixtures with air at concentrations of 2 to 11.5% (by volume).

Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide.
Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires.

Waste Disposal:
Dissolve or mix Ethyl acetate with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
All federal, state, and local environmental regulations must be observed.

Consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Synonyms
ETHYL ACETATE
141-78-6
Ethyl ethanoate
Acetoxyethane
Acetic acid ethyl ester
Vinegar naphtha
Acetic ether
Ethyl acetic ester
Acetic acid, ethyl ester
Acetidin
Ethylacetate
Essigester
EtOAc
Acetic ester
Aethylacetat
Ethylacetat
1-acetoxyethane
AcOEt
RCRA waste number U112
Ethylacetaat
Octan etylu
FEMA No. 2414
Etile (acetato di)
Ethylazetat
Caswell No. 429
Ethyle (acetate d')
Acetate d'ethyle
Acetato de etilo
Ethyl acetate (natural)
Ethylester kyseliny octove
CHEBI:27750
Essigsaeureethylester
Essigester [German]
Ethylacetaat [Dutch]
acetic-acid-ethylester
HSDB 83
Aethylacetat [German]
NSC 70930
Octan etylu [Polish]
CCRIS 6036
acet-ethylester
ethyl-acetate
acet-eth-ester
acetic acid ethyl
Acetate d'ethyle [French]
Ethyl ester of acetic acid
Acetato de etilo [Spanish]
EINECS 205-500-4
MFCD00009171
NSC-70930
CH3-CO-O-CH3
EPA Pesticide Chemical Code 044003
UNII-76845O8NMZ
Etile (acetato di) [Italian]
Ethyl acetate [NF]
Ethyle (acetate d') [French]
DTXSID1022001
Ethyl Acetate, HPLC
AI3-00404
76845O8NMZ
Ethylester kyseliny octove [Czech]
UN1173
RCRA waste no. U112
DTXCID602001
EC 205-500-4
ETHYL ACETATE (1-13C)
ETHYL ACETATE (2-13C)
NSC70930
Ethyl acetate (NF)
NCGC00091766-01
E1504
ETHYL ACETATE (II)
ETHYL ACETATE [II]
Ethyl acetate, ACS reagent
ETHYL ACETATE (MART.)
ETHYL ACETATE [MART.]
Ethyl acetate; Ethyl ethanoate
ETHYL ACETATE (EP MONOGRAPH)
ETHYL ACETATE [EP MONOGRAPH]
Ethyl acetate, ACS reagent, >=99.5%
CAS-141-78-6
CH3COOC2H5
ethylaceate
ethylactate
ethylacteate
Etylacetat
Etylacetate
ehtyl acetate
ethanol acetate
ethly acetate
ethyl acteate
ethyl_acetate
ehyl acetate
ethl acetate
ethy acetate
ethyl aceate
ethyl actate
etyl acetate
Acetyl ester
1-ethyl acetate
2~ethyl acetate
acetic ethyl ester
Etile(acetato di)
Et-OAc
Ethyle(acetate d')
Caswell No 429
acetic acid ethylester
CH3CO2Et
ETA (CHRIS Code)
Ethyl acetate HPLC grade
Ethyl acetate, for HPLC
Ethyl acetate, 99.9%
Ethyl acetate, ACS grade
CH3CO2CH2CH3
Epitope ID:116868
ETHYL ACETATE [MI]
Ethyl acetate, HPLC Grade
CH3CO2C2H5
ETHYL ACETATE [FCC]
ETHYL ACETATE [FHFI]
ETHYL ACETATE [HSDB]
ETHYL ACETATE [INCI]
ETHYL ACETATE 100ML
Ethyl acetate, >=99.5%
WLN: 2OV1
CHEMBL14152
ACETIC ACID,ETHYL ESTER
Ethyl acetate, AR, >=99%
Ethyl acetate, LR, >=99%
ETHYL ACETATE [USP-RS]
ETHYL ACETATE [WHO-DD]
2-Oxo-2-ethoxyethylidyne radical
Ethyl acetate, analytical standard
Ethyl acetate, Environmental Grade
Ethyl acetate, anhydrous, 99.8%
Ethyl acetate, 99.9% low benzene
Tox21_111166
Tox21_202512
BDBM50128823
c0036
LS-831
NA1173
STL282717
Ethyl acetate, >=99%, FCC, FG
Ethyl acetate, HPLC grade, 99.8%
AKOS000121947
Ethyl acetate, Spectrophotometric Grade
UN 1173
Ethyl acetate, for HPLC, >=99.5%
Ethyl acetate, for HPLC, >=99.7%
Ethyl acetate, for HPLC, >=99.8%
Ethyl acetate, PRA grade, >=99.5%
NCGC00260061-01
Ethyl acetate, biotech. grade, >=99.8%
Ethyl acetate, ReagentPlus(R), >=99.5%
Ethyl acetate, ReagentPlus(R), >=99.8%
Ethyl acetate, tested according to Ph.Eur.
A0030
Ethyl acetate [UN1173] [Flammable liquid]
Ethyl acetate 100 microg/mL in Acetonitrile
Ethyl acetate, natural, >=99%, FCC, FG
Ethyl acetate, SAJ first grade, >=99.0%
FT-0621744
FT-0693343
Q0040
EN300-31487
Ethyl acetate [UN1173] [Flammable liquid]
Ethyl acetate, for HPLC, >=99.8% (GC)
Ethyl acetate, JIS special grade, >=99.5%
J3.639.860D
C00849
D02319
Ethyl acetate, capillary GC grade, >=99.5%
A807811
Q407153
Ethyl acetate, Laboratory Reagent, >=99.0% (GC)
Ethyl acetate, UV-IR min. 99.8%, isocratic grade
J-007556
J-521240
F0001-0489
InChI=1/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H
Ethyl acetate, puriss. p.a., ACS reagent, >=99.5% (GC)
Ethyl acetate, United States Pharmacopeia (USP) Reference Standard
Ethylacetate, pure, meets the analytical specifications of Ph. Eur.
Ethyl Acetate, Pharmaceutical Secondary Standard; Certified Reference Material
Ethyl acetate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5% (GC)
Ethyl acetate, puriss. p.a., free of higher boiling impurities, >=99.9% (GC)
Ethyl acetate, puriss., meets analytical specification of Ph. Eur., BP, NF, >=99.5% (GC)