Le benzoate de benzyle est un composé organique utilisé comme médicament et insectifuge. En tant que médicament, il est utilisé pour traiter la gale et les poux. Pour la gale, la perméthrine ou le malathion sont généralement préférés. Il est appliqué sur la peau sous forme de lotion. En règle générale, deux à trois applications sont nécessaires. Il est également présent dans le baume du Pérou, le baume de Tolu et dans un certain nombre de fleurs. Le benzoate de benzyle a été étudié médicalement pour la première fois en 1918. Il figure sur la liste des médicaments essentiels de l'Organisation mondiale de la santé.
No CAS: 120-51-4
No CE: 204-402-9
Noms IUPAC:
Benzil-benzoát
ester phénylméthylique d'acide benzoïque
Acide benzoïque, ester benzylique
ACIDE BENZOIQUE, ESTER PHÉNYL-MÉTHYLE
Acide benzoïque, ester phénylméthylique
Benxoate de benzyle
BENZOATE DE BENZYLE
Benzoate de benzyle; Benzoate de phénylméthyle
benzyl-2-méthyl-hydroxybutyrate déshydrogénase
benzylbenzoate
benzoate de phénylméthyle
SYNONYMES
Ascabiol; Novoscabin; Benylate; Scabitox; Scobenol; Ascabin; Ester benzylique d'acide benzoïque; Phénylformate de benzyle; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Ester phénylméthylique d'acide benzoïque; Benzoate de phénylméthyle; Antiscabiosum; Acide benzoique; ester benzylique; Benzyl benzène carboxylate; Benzylis benzoas; Ester benzoïque d'alcool benzylique; Benzylbenzoate; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum; 120-51-4; Ascabiol; Acide benzoïque, ester phénylméthylique; Ester benzylique d'acide benzoïque; Benylate; Novoscabine; Acide benzoïque, ester benzylique; Ascabine; Scabitox; Scobénol; Phénylformate de benzyle; Phénylméthyl benzoate; Benzylets; Coleinbenz Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; benzylbenzoate; Benzyl benzenecarboxylate; Benzyl alcool benzoic ester; Venzonate; Benzylester kyseliny benzoove; BENZOIC ACID PHENYLMETHYLESTER; FEMA No 2138; NSC 8081; UNIIum-N863IS 41237; N863NB338G; NSC-8081; NCGC00094981-03; Peruscabina; Spasmodine; Benzoate de benzyle, 99 +%; Benzylis benzoas; DSSTox_CID_9153; Benzylum benzoicum; DSSTox_RID_78686; DSSTox_GSZo-boxo standard; Benzyl benzoate (naturel); BZM; CAS-120-51-4; SMR000471875; HSDB 208; EINECS 204-402-9; Benzylester kyseliny benzoove [tchèque]; EPA Pesticide Chemical Code 009501; benzylbenzoat; BRN 2049280; Benzyl benzoate [USP: JAN ]; Acarobenzyle; Benzevan; Bengale; Ester phénylméthylique de l'acide benzoïque; AI3-00523; 1dzm; Benylate (TN); acide benzoïque benzyle; Spectrum_001240; Ester d'acide benzoïque-benzylique; Spectrum2_000532; Spectrum3_001757; Spectrum4_00028C1; Spectrum3_001757; Spectrum4_00028C11; Spectrum3_001757; Spectrum4_000281C-AC RVO1R; benzoate de benzyle,> = 99%; EC 204-402-9; SCHEMBL3038; BENZOATE DE BENZYLE BP98; BSPBio_003494; KBioGR_001186; KBioSS_001720; 4-09-00-00307 (référence du manuel de Beilstein); MLS001066412; MLS0013K136003; MLS001066412; MLS0013K1603_ SPECTRUM1503002; SPBio_000543; Benzoate de benzyle (JP17 / USP); ZINC1021; DTXSID8029153; ACIDE BENZOIQUE, ESTER DE BENZYLE; HMS500K06; KBio1_000204; KBio2_001720; KBio2_004288; KBio2_006856;
. > = 99%, FCC, FG; Tox21_111372_1; DB00676; MCULE-4369643785; NSC-758204; IDI1_000204; Benzoate de benzyle, pour la synthèse, 99,0%; NCGC00094981-01; NCGC00094981-02
258889-01; AC-17033; AK308304; SBI-0051748.P002; DB-041563; B0064; FT-0622708; ST50406335; Benzoate de benzyle, naturel,> = 99%, FCC, FG; Benzoate de benzyle, ReagentPlus (R), > = 99,0%; Benzoate de benzyle, première qualité SAJ,> = 98,0%; Benzoate de benzyle, testé selon Ph.Eur.; A14577; A19449; Benzoate de benzyle, qualité spéciale SAJ,> = 99,0%; C12537; D01138; AB00052298_07; Benzoate de benzyle, qualité réactif Vetec (TM), 98%; Benzoate de benzyle; Q413755; SR-01000763773; Ester benzylique d'acide benzoïque 5000 microg / mL dans l'hexane; Q-200696; SR-01000763773-2; BRD-K52072429-001- 06-1; ester benzylique d'acide benzoïque; Ester phénylméthylique d'acide benzoïque
Le benzoate de benzyle (BnBzO) est un agent de médiation et un insectifuge. C'est l'une des préparations les plus anciennes utilisées pour traiter la gale, une infection cutanée causée par l'acarien Sarcoptes scabiei car elle est mortelle pour l'acarien. Il est capable de tuer l'acarien en 5 minutes. Il peut également être utilisé pour le traitement de l'infestation par les poux de la tête et du corps. Son mécanisme d'action consiste à exercer des effets toxiques sur le système nerveux des insectes, provoquant en outre sa mort. Il est également toxique pour les ovules d'acariens par un mécanisme inconnu. Il peut également être utilisé comme répulsif pour les aoûtats, les tiques et les moustiques, ainsi que comme support de colorant, solvant des dérivés de cellulose, plastifiant et fixateur.
Les usages
Médical
Le benzoate de benzyle est un traitement topique efficace et peu coûteux pour la gale humaine. Il a des effets vasodilatateurs et spasmolytiques et est présent dans de nombreux médicaments contre l'asthme et la coqueluche. Il est également utilisé comme excipient dans certains médicaments de remplacement de la testostérone (comme Nebido) pour traiter l'hypogonadisme.
Le benzoate de benzyle est utilisé comme acaricide topique, scabicide et pédiculicide dans les hôpitaux vétérinaires.
Non médical
Le benzoate de benzyle est utilisé comme répulsif pour les aoûtats, les tiques et les moustiques. Il est également utilisé comme support de colorant, solvant pour les dérivés de cellulose, plastifiant et fixateur dans l'industrie du parfum.
Chimie
C'est un composé organique de formule C6H5CH2O2CC6H5. C'est l'ester de l'alcool benzylique et de l'acide benzoïque. Il forme un liquide visqueux ou des flocons solides et dégage une faible odeur de balsamique sucré. Il se produit dans un certain nombre de fleurs (par exemple la tubéreuse) et est un composant du baume du Pérou et du baume de Tolu.
Production
Le benzoate de benzyle est produit industriellement par réaction du benzoate de sodium avec de l'alcool benzylique en présence d'une base, ou par transestérification du benzoate de méthyle et de l'alcool benzylique. C'est un sous-produit de la synthèse de l'acide benzoïque par oxydation du toluène. Il peut également être synthétisé par la réaction de Tishchenko, en utilisant du benzaldéhyde avec du benzilate de sodium (généré à partir de sodium et d'alcool benzylique) comme catalyseur:
La réaction de Tishchenko: le benzaldéhyde réagit au benzoate de benzyle, le catalyseur est le benzilate de sodium.
Il se produit naturellement dans les huiles essentielles telles que l'ylang-ylang, le bois de rose, la cannelle et le benjoin.
Lorsque ces huiles essentielles ne sont pas utilisées dans un produit, le benzoate de benzyle peut être ajouté sous sa forme synthétique en raison de son parfum incroyable et de ses excellentes propriétés de solvant. En effet, il dissout les autres matières parfumées, leur permettant de se fondre plus facilement.
Qu'est-ce que le benzoate de benzyle?
Le benzoate de benzyle est une molécule naturelle que l'on trouve dans certaines plantes et se compose d'alcool benzylique et d'acide benzoïque. Dans les produits cosmétiques, il joue un certain nombre de rôles en fonction du produit et il peut agir comme un parfum, un solvant, un plastifiant, un conservateur et un fixateur.
Comment ça marche?
En tant que parfum, le benzoate de benzyle peut ajouter une odeur balsamique à un produit. Il peut également fonctionner avec d'autres parfums comme solvant pour les aider à se dissoudre dans le mélange. Le benzoate de benzyle agit également comme fixateur dans les produits parfumés où il ralentit la fuite d'autres parfums et augmente la durée de vie du parfum.
Lorsqu'il est ajouté à des produits plus solides comme les savons, le benzoate de benzyle peut agir comme plastifiant. Un plastifiant rend un produit moins cassant, de sorte qu'un savon qui le contient peut être plié et écrasé davantage avant qu'il ne craque ou ne s'effrite.
Le benzoate de benzyle est utilisé pour traiter les infestations de poux et de gale. On pense que ce médicament est absorbé par les poux et les acariens et les détruit en agissant sur leur système nerveux.
Le benzoate de benzyle est l'une des préparations les plus anciennes utilisées pour traiter la gale. La gale est une infection cutanée causée par l'acarien Sarcoptes scabiei. Elle se caractérise par de fortes démangeaisons (en particulier la nuit), des taches rouges et peut conduire à une infection secondaire. Le benzoate de benzyle est mortel pour cet acarien et est donc utile dans le traitement de la gale. Il est également utilisé pour traiter les infestations de poux de la tête et du corps.
Mécanisme d'action
Le benzoate de benzyle exerce des effets toxiques sur le système nerveux du parasite, entraînant sa mort. Il est également toxique pour les ovules d'acariens, bien que son mécanisme d'action exact soit inconnu. In vitro, le benzoate de benzyle tue l'acarien Sarcoptes en 5 minutes.
Absorption
Aucune donnée n'est disponible sur l'absorption percutanée du benzoate de benzyle. Certaines études plus anciennes ont suggéré une certaine absorption percutanée, cependant, la quantité n'a pas été quantifiée.
Métabolisme
Rapidement hydrolysé en acide benzoïque et en alcool benzylique, qui est ensuite oxydé en acide benzoïque. L'acide benzoïque est conjugué à la glycine pour former de l'acide hippurique.
Le benzoate de benzyle est un composé benzylique qui peut être synthétisé en faisant réagir du chlorure de benzyle avec du benzoate de sodium en présence d'iodure de tétrabutylaramonium. Il serait le constituant clé des huiles essentielles isolées des feuilles et de l'écorce de tige de Cinnamomum zeylanicum.
Le benzoate de benzyle, un ester d'alcool benzylique et d'acide benzoïque, est largement utilisé comme fixateur de parfum, ingrédient de parfum et conservateur pour maintenir la puissance et la stabilité d'une variété de formulations cosmétiques. Il est également utilisé comme musc synthétique, acaricide pour traiter la gale et les poux de tête.
L'alcool benzylique est un alcool organique présent dans de nombreux fruits et thés. L'alcool benzylique a un groupe hydroxyle, tandis que le composé apparenté, l'acide benzoïque, a un groupe carboxyle. Le benzoate de sodium, le benzoate de calcium et le benzoate de potassium sont des sels d'acide benzoïque. Le benzoate de benzyle est un ester d'alcool benzylique et d'acide benzoïque.
L'alcool benzylique, l'acide benzoïque et ses sels et le benzoate de benzyle sont utilisés dans une grande variété de cosmétiques et de produits de soins personnels, y compris les produits pour bébés, les produits de bain, les savons et détergents, le maquillage des yeux, les fards à joues, les produits nettoyants, les produits de maquillage, ainsi que produits de soin des cheveux, des ongles et de la peau.
Pourquoi est-il utilisé dans les cosmétiques et les produits de soins personnels?
Les fonctions suivantes ont été rapportées pour ces ingrédients.
Inhibiteur de corrosion - Benzoate de sodium
Ingrédient de parfum - alcool benzylique, acide benzoïque, benzoate de sodium, benzoate de benzyle
Ajusteur de pH - Acide benzoïque
Conservateur - alcool benzylique, acide benzoïque, benzoate de sodium, benzoate de calcium, benzoate de potassium
Solvant - Alcool benzylique, Benzoate de benzyle Agent de diminution de la viscosité - Alcool benzylique
Le benzoate de benzyle est un liquide huileux clair, incolore avec une légère odeur balsamique rappelant l'amande et un goût piquant et piquant. Il produit une sensation vive et brûlante sur la langue. À des températures inférieures à 178 ℃, il existe sous forme de cristaux clairs et incolores.
Applications pharmaceutiques
Le benzoate de benzyle est utilisé comme agent solubilisant et solvant non aqueux dans les injections intramusculaires à des concentrations de 0,01 à 46,0% v / v, et comme solvant et plastifiant pour la cellulose et la nitrocellulose. Il est également utilisé dans la préparation de poudres séchées par atomisation à l'aide de nanocapsules.
Cependant, l'utilisation pharmaceutique la plus répandue du benzoate de benzyle est comme agent thérapeutique topique dans le traitement de la gale. Le benzoate de benzyle est également utilisé en thérapeutique comme parasiticide en médecine vétérinaire.
D'autres applications du benzoate de benzyle comprennent son utilisation comme pédiculicide et comme solvant et fixateur pour les arômes et les parfums dans les cosmétiques et les produits alimentaires.
Allergènes de contact Le benzoate de benzyle est l'ester de l'alcool benzylique et de l'acide benzoïque. Il est contenu dans Myroxylon pereirae et Tolu balsam. Il est utilisé dans les préparations acaricides contre Sarcoptes scabiei ou comme pédiculicide. Le contact direct peut provoquer une irritation cutanée, mais rarement une dermatite de contact allergique.
Utilisation clinique
Le benzoate de benzyle est un ester naturel obtenu à partir du baume du Pérou et d'autres résines. Il est également préparé synthétiquement à partir d'alcool benzylique et de chlorure de benzoyle. L'ester est un liquide clair incolore avec une légère odeur aromatique. Il est insoluble dans l'eau mais soluble dans les solvants organiques.
Le benzoate de benzyle est un scabicide efficace lorsqu'il est appliqué localement. Le soulagement immédiat des démangeaisons résulte probablement d'un effet anesthésique local; cependant, un durcissement complet est fréquemment obtenu avec une seule application d'une émulsion à 25% de benzoate de benzyle dans l'acide oléique, stabilisée avec de la triéthanolamine. Cette préparation présente l'avantage supplémentaire d'être essentiellement inodore, non tachante et non irritante pour la peau. Il est appliqué localement sous forme de lotion sur tout le corps humidifié, à l'exception du visage.
Le benzoate de benzyle est un ester de benzoate obtenu par condensation formelle d'acide benzoïque avec de l'alcool benzylique. Il a été isolé des espèces végétales du genre Polyalthia. Il a un rôle de scabicide, d'acaricide et de métabolite végétal. C'est un ester benzylique et un ester benzoate. Il dérive de l'acide benzoïque.
Principalement utilisé comme pesticide non agricole avec certaines applications vétérinaires ainsi que comme additif alimentaire et en parfumerie.
Le benzoate de benzyle est un ester aromatique utilisé comme agent aromatisant alimentaire. Il a été identifié comme l'un des principaux composants aromatiques volatils des fleurs de canneberge, de mangue et de Jasminum sambac égyptien.
Il a une odeur unique. Il a un parfum d'amande ou de balsamique. Il se présente sous une forme solide ou liquide incolore.
Le point d'ébullition est de 323,5 ° C.
Le point de fusion est de 21 ° C.
Sa solubilité dans l'eau est presque négligeable. Il a une solubilité d'environ 25 mg / L à 25 ° C.
Il est insoluble dans la glycérine. Soluble dans l'alcool éthylique, l'alcool méthylique, le chloroforme et l'éther éthylique.
La densité du benzoate de benzyle est de 25 ° C: 1,112 g / cm³.
C'est un composé chimique stable dans des conditions de stockage standard.
Domaines d'utilisation du benzoate de benzyle:
• Il est utilisé dans la création des formules les plus anciennes utilisées pour le traitement d'une maladie de la peau appelée gale. Ceci est une infection cutanée. Il est utilisé pour éliminer ces infections cutanées.
• C'est un ingrédient utilisé dans la fabrication de médicaments destinés à inhiber les tiques et les moustiques.
• C'est une substance chimique utilisée comme solvant dans de nombreuses substances chimiques.
• Il est utilisé comme solvant pour les substances cellulosiques.
• Il est utilisé comme essence dans la production de parfums.
• Il est utilisé dans la production de médicaments vétérinaires, dans les produits chimiques produits pour le traitement des maladies de la peau des animaux.
• Il est utilisé comme édulcorant dans le secteur alimentaire.
• Il est utilisé dans la fabrication de pesticides pour le traitement des poussières dans certains textiles, tapis, matelas et tissus d'ameublement et meubles de canapés.
Usage
C'est l'un des médicaments anti-gale les plus anciens à usage humain et vétérinaire. Il est également utilisé en association avec d'autres agents contre les poux de tête et dans les crèmes de protection cutanée.
Il est également utilisé comme solvant, comme ingrédient de parfum dans les produits du tabac et pour augmenter la plasticité des polymères et de la cellulose.
COMMENT EST PRODUIT LE BENZOATE DE BENZYLE
Le benzoate de benzyle est une molécule naturellement présente dans certaines plantes (espèces végétales du genre Polyalthia) et se compose d'alcool benzylique et d'acide benzoïque. Le benzoate de benzyle a été étudié médicalement pour la première fois en 1918.
C'est un ester benzoate obtenu par condensation formelle d'acide benzoïque avec de l'alcool benzylique. Il peut également être produit par la réaction de Tishchenko, en utilisant du benzaldéhyde avec du benzylate de sodium (produit à partir de sodium et d'alcool benzylique) comme catalyseur.
PROPRIÉTÉS PHYSIQUES ET CHIMIQUES DU BENZOATE DE BENZYLE
• Le benzoate de benzyle est insoluble dans l'eau et le glycérol. Soluble dans l'éthanol, l'éther éthylique, l'acétone, le benzène, le méthanol, le chloroforme.
• Le benzoate de benzyle est stable dans les conditions de stockage recommandées.
• Le benzoate de benzyle, lorsqu'il est chauffé pour se décomposer, produit des fumées amères et irritantes.
• Il se présente sous la forme d'un liquide visqueux ou de flocons solides et a une faible odeur balsamique.
Le benzoate de benzyle a un poids moléculaire élevé, ce qui en fait un fixateur largement utilisé dans l'industrie des parfums fins. Il est utilisé dans les formulations pharmaceutiques topiques pour le traitement des poux et de la gale. De plus, le benzoate de benzyle de Kalama est apprécié pour sa compatibilité avec la cire de bougie, incorporant un parfum aux bougies fines tout en favorisant une combustion propre.
Le traitement de la gale est avec la perméthrine topique, le benzoate de benzyle, le malathion, à son ir ou ivermectine orale. Le patient doit appliquer une crème de perméthrine à 5% sur tout le corps, y compris le cuir chevelu, tous les plis, l'aine, le nombril, les organes génitaux externes et la peau sous les ongles, en le lavant après 12 heures. Chez les adultes atteints de gale classique, le traitement du visage est controversé, mais chez les bébés, la peau du visage doit également être traitée. Une deuxième application 7 jours après le traitement initial doit être prescrite et tous les membres affectés d'un ménage doivent être traités en même temps pour éviter les réinfestations cycliques. L'ivermectine orale est de plus en plus utilisée comme traitement de première intention. Les flambées graves nécessitent une deuxième dose d'ivermectine à 2 semaines d'intervalle (200 µg / kg de poids corporel). Un traitement de l'infection bactérienne secondaire et des antihistaminiques peuvent être nécessaires. Laver les vêtements et le linge à 60 ° C tuera tous les jeunes acariens femelles fécondés (une alternative est de les conserver dans un sac en plastique pendant 48 à 72 heures, car les acariens séparés de l'hôte humain meurent dans ce délai). Il est important d'expliquer que le prurit dure généralement plusieurs semaines après la guérison, ce qui peut être partiellement atténué par des antihistaminiques non sédatifs ou sédatifs.
Le benzoate de benzyle est utilisé comme insecticide pour tuer les acariens de la gale, les acariens et les tiques. Il est également utilisé comme plastifiant, fixateur dans les parfums, additif alimentaire et solvant. La dermatite est la principale réaction indésirable à son utilisation comme solution topique. À des concentrations élevées, il s'est avéré posséder des propriétés œstrogéniques et stimuler la croissance des cellules mammaires humaines.
IDENTIFICATION:
Le benzoate de benzyle est un liquide huileux incolore. Il peut également se présenter sous forme de dépliants. Il a un goût d'amande et une odeur agréable. Il est presque insoluble dans l'eau. Le benzoate de benzyle est présent dans de nombreuses plantes et huiles essentielles.
UTILISER:
Le benzoate de benzyle est un produit chimique commercial important. Il est utilisé dans la fabrication de plastiques, comme solvant, dans la fabrication d'autres produits chimiques, comme arôme alimentaire et dans les parfums. Il est également utilisé comme médicament pour la peau chez les humains et les chiens dans le traitement des acariens. Le benzoate de benzyle est utilisé pour lutter contre les acariens dans les tapis et les meubles.
EXPOSITION:
Les travailleurs qui utilisent du benzoate de benzyle peuvent respirer des vapeurs ou avoir un contact direct avec la peau. La population générale peut être exposée aux vapeurs, au contact cutané et à la consommation d'aliments contenant du benzoate de benzyle. Si du benzoate de benzyle est rejeté dans l'environnement, il se décomposera dans l'air. Il peut être décomposé par la lumière du soleil. Il ne se déplacera pas dans l'air du sol humide et de l'eau. Il ne devrait pas se déplacer dans le sol. Il sera décomposé par les micro-organismes et devrait s'accumuler dans les poissons.
Utilisations de l'industrie
• Colorants
• Agents odorants
• Solvants (pour le nettoyage et le dégraissage)
• Solvants (qui font partie de la formulation ou du mélange du produit)
• Agents tensioactifs
Informations générales sur la fabrication
Secteurs de traitement de l'industrie
• Entretien de l'air
• Toute autre fabrication de produits chimiques organiques de base
• Fabrication de tous les autres produits chimiques et préparations
• Fabrication diverses
• Fabrication de matière plastique et résine
• Fabrication de savons, de produits de nettoyage et de préparations pour toilettes
• Fabrication de textiles, de vêtements et de cuir
• Fragrance
À propos de cette substance
Information utile
Cette substance est utilisée par les consommateurs, par les professionnels (usages répandus), en formulation ou en reconditionnement, sur les sites industriels et en fabrication.
Utilisations des consommateurs
Cette substance est utilisée dans les produits suivants: produits de lavage et de nettoyage, vernis et cires, produits de soin de l'air, cosmétiques et produits de soins personnels, parfums et fragrances et biocides (par ex. Désinfectants, produits antiparasitaires).
Un autre rejet dans l'environnement de cette substance est susceptible de se produire à la suite de: l'utilisation à l'intérieur comme auxiliaire technologique et l'utilisation à l'extérieur comme auxiliaire technologique.
Utilisations généralisées par les travailleurs professionnels
Cette substance est utilisée dans les produits suivants: produits de polissage, produits de lavage et de nettoyage, parfums et parfums et cosmétiques et produits de soins personnels.
Cette substance est utilisée dans les domaines suivants: services de santé et recherche et développement scientifiques.
Un autre rejet dans l'environnement de cette substance est susceptible de se produire en raison de: l'utilisation à l'intérieur (par exemple, les liquides / détergents de lavage en machine, les produits d'entretien automobile, les peintures et revêtements ou adhésifs, les parfums et les assainisseurs d'air) et l'utilisation à l'extérieur comme auxiliaire technologique.
Formulation ou réemballage
Cette substance est utilisée dans les produits suivants: produits de soin de l'air, biocides (par exemple désinfectants, produits antiparasitaires), produits de traitement du cuir, parfums et parfums, produits pharmaceutiques, photo-chimiques, cirages et cires, polymères, produits de traitement et colorants textiles, lavage & produits de nettoyage et cosmétiques et produits de soins personnels.
Le rejet dans l'environnement de cette substance peut se produire à la suite d'une utilisation industrielle: formulation de mélanges.
Utilisations sur les sites industriels
Cette substance est utilisée dans les produits suivants: produits de lavage et de nettoyage, polymères, produits chimiques de laboratoire, produits de soin de l'air, produits de revêtement, parfums et parfums, cirages et cires, produits de traitement et colorants textiles et produits cosmétiques et de soins personnels.
Cette substance a une utilisation industrielle entraînant la fabrication d'une autre substance (utilisation d'intermédiaires).
Cette substance est utilisée pour la fabrication de produits chimiques, de produits en plastique et de textile, de cuir ou de fourrure.
benzoate de benzyle comme une odeur incolore et agréable, goût liquide huileux très piquant. L'acide benzoïque et l'ester d'alcool benzylique. Insoluble dans l'eau, l'acétone et le benzène soluble dans l'alcool, le chloroforme, les mélanges d'éther, les huiles.
Dans la nature, il se produit dans les gyömbérfélékhez appartenant à Kaempferia rotunda et Zingiber cassumunar le nom de la plante.
Le benzoate de benzyle est un composant naturel des huiles essentielles (par exemple le jasmin, l'ylang-ylang, le bois de rose, la cannelle ou le benzoate). Le benzoate de benzyle peut également être produit par synthèse, mais les effets ne diffèrent pas. Il se présente sous la forme d'un liquide incolore ou d'un solide blanc avec une odeur balsamique plus sucrée. C'est l'un des allergènes et peut provoquer une dermatite de contact, en particulier avec une utilisation fréquente, car il pénètre dans les couches les plus profondes de la peau, il n'est donc pas recommandé pour les peaux plus sensibles.
Le benzoate de benzyle est une substance stable, résistante aux changements de température et d'environnement, il est utilisé comme stabilisant des compositions parfumées et de l'ensemble du produit. Il masque l'arôme naturel des ingrédients non parfumés, tout en servant également de parfum grâce à son doux parfum balsamique. Il agit également comme conservateur et surtout comme solvant (il dissout d'autres substances dans le produit). On le retrouve dans les médicaments pour traiter la gale (tue les acariens de la gale), les préparations anti-poux et les insecticides. Il a des effets antimicrobiens.
Occurrence
Contenue dans le baume du Pérou et dans le béton et l'absolu de fleurs de tubéreuse, de jacinthe, de Narcissus jonquilla L. et de Dianthus caryophillus L .; également dans l'huile d'ylang-ylang et dans le baume de Tolu. Signalé trouvé dans la canneberge américaine, l'écorce de cannelle, la feuille de cassia, l'huile de maïs et la prune de porc (Spondias mombins L.).
Les usages
Le benzoate de benzyle, en tant que solution topique, peut être utilisé comme insecticide antiparasitaire pour tuer les acariens responsables de l'affection cutanée de la gale, par exemple en tant que médicament combiné de benzoate de benzyle / disulfirame.
Il a d'autres utilisations:
• un fixateur dans les parfums pour améliorer la stabilité et les autres caractéristiques des principaux ingrédients
• un additif alimentaire aux arômes artificiels
• un plastifiant dans la cellulose et autres polymères
• un solvant pour diverses réactions chimiques
• un traitement pour les démangeaisons douces chez les chevaux
• un traitement contre les acariens des pattes squameuses chez les poulets.
Le benzoate de benzyle est un antimicrobien. Il peut également agir comme solvant, aidant à dissoudre d'autres substances dans le produit et comme ingrédient parfumant. C'est l'ester de l'alcool benzylique et de l'acide benzoïque.
En tant que solvant de l'acétate de cellulose, de la nitrocellulose et du musc artificiel; substitut du camphre dans les composés celluloïdes et plastiques pyroxyline; fixateur de parfum; dans les saveurs de confiserie et de chewing-gum.
Préparation
Par estérification à sec du benzoate de sodium et du chlorure de benzoyle en présence de triéthylamine ou par réaction du benzylate de sodium sur le benzaldéhyde.
Méthodes de production
Le BENZOATE DE BENZYLE est produit par la réaction de Cannizzaro à partir du benzaldéhyde, en estérifiant l'alcool benzylique avec de l'acide benzoïque ou en traitant le benzoate de sodium avec du chlorure de benzyle. Il est purifié par distillation et cristallisation. Le benzoate de benzyle est utilisé comme fixateur et solvant pour le musc dans les parfums et les arômes, comme plastifiant, acaricide et dans certains médicaments externes. Le composé s'est avéré efficace dans le traitement de la gale et de la pédiculose capitis (poux de tête, Pediculus humanus var. Capitis).
Les indications
Benzoate de benzyle: 20% à 25%. Cet agent est relativement non toxique et est largement utilisé dans les pays en développement pour traiter la gale et la pédiculose de la tête et du pubis. Seule la préparation vétérinaire est disponible aux États-Unis. Le benzoate de benzyle est dérivé synthétiquement de l'estérification de l'acide benzoïque avec de l'alcool benzylique. Son mécanisme d'action est inconnu. Il est toxique pour Sarcoptes scabei et peut être toxique pour Pediculosis capitis et Phthirus pubis. Aucune résistance n'a été démontrée à ce jour.
Le benzoate de benzyle peut être utilisé dans une émulsion à 5% pour repousser de nombreux arthropodes et peut être utilisé comme lotion pour traiter la gale sarcoptique et la pédiculose canine.
marque
La nécessité pharmaceutique du dimercaprol [injection]. Besylate (Sterling Winthrop).
Valeurs de seuil de goût
Caractéristiques gustatives à 30 ppm: balsamique, fruité avec des nuances poudrées et baies.
Applications pharmaceutiques
Le benzoate de benzyle est utilisé comme agent solubilisant et solvant non aqueux dans les injections intramusculaires à des concentrations de 0,01 à 46,0% v / v, et comme solvant et plastifiant pour la cellulose et la nitrocellulose. Il est également utilisé dans la préparation de poudres séchées par atomisation à l'aide de nanocapsules.
Cependant, l'utilisation pharmaceutique la plus répandue du benzoate de benzyle est comme agent thérapeutique topique dans le traitement de la gale. Le benzoate de benzyle est également utilisé en thérapeutique comme parasiticide en médecine vétérinaire.
D'autres applications du benzoate de benzyle comprennent son utilisation comme pédiculicide et comme solvant et fixateur pour les arômes et les parfums dans les cosmétiques et les produits alimentaires.
Le benzoate de benzyle est l'ester de l'alcool benzylique et de l'acide benzoïque. Il est contenu dans Myroxylon pereirae et Tolu balsam. Il est utilisé dans les préparations acaricides contre Sarcoptes scabiei ou comme pédiculicide.
Utilisation clinique
Le benzoate de benzyle est un ester naturel obtenu à partir du baume du Pérou et d'autres résines. Il est également préparé synthétiquement à partir d'alcool benzylique et de chlorure de benzoyle. L'ester est un liquide clair incolore avec une légère odeur aromatique. Il est insoluble dans l'eau mais soluble dans les solvants organiques.
Le benzoate de benzyle est un scabicide efficace lorsqu'il est appliqué localement. Le soulagement immédiat des démangeaisons résulte probablement d'un effet anesthésique local; cependant, un durcissement complet est fréquemment obtenu avec une seule application d'une émulsion à 25% de benzoate de benzyle dans l'acide oléique, stabilisée avec de la triéthanolamine. Cette préparation présente l'avantage supplémentaire d'être essentiellement inodore, non tachante et non irritante pour la peau. Il est appliqué localement sous forme de lotion sur tout le corps humidifié, à l'exception du visage.
Le benzoate de benzyle CAS 120-51-4 est un liquide transparent visqueux incolore ou jaune pâle. Dans des conditions de température de 17 degrés centigrades ou moins, il sera solidifié en solide
Benzyl benzoate is an organic compound that is used as a medication and insect repellent. As a medication, it is used to treat scabies and lice. For scabies either permethrin or malathion is typically preferred. It is applied to the skin as a lotion. Typically two to three applications are needed. It is also present in Balsam of Peru, Tolu balsam, and in a number of flowers. Benzyl benzoate was first studied medically in 1918. It is on the World Health Organization's List of Essential Medicines.
CAS NO: 120-51-4
EC NO: 204-402-9
IUPAC Names:
Benzil-benzoát
benzoic acid phenylmethyl ester
Benzoic acid, benzylester
BENZOIC ACID, PHENYL METHYL ESTER
Benzoic acid, phenylmethyl ester
Benzyl benxoate
BENZYL BENZOATE
Benzyl benzoate; Phenylmethyl benzoate
benzyl-2-methyl-hydroxybutyrate dehydrogenase
benzylbenzoate
phenylmethyl benzoate
SYNONYMS
Ascabiol; Novoscabin; Benylate; Scabitox; Scobenol; Ascabin; Benzoic acid benzyl ester; Benzyl phenylformate; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzoic acid phenylmethyl ester; Phenylmethyl benzoate; Antiscabiosum; Benzoic acid; benzyl ester; Benzyl benzenecarboxylate; Benzylis benzoas; Benzyl alcohol benzoic ester; Benzylbenzoate; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum;120-51-4;Ascabiol;Benzoic acid, phenylmethyl ester;Benzoic acid benzyl ester;Benylate;Novoscabin;Benzoic acid, benzyl ester;Ascabin;Scabitox;Scobenol;Benzyl phenylformate;Phenylmethyl benzoate;Benzylets;Colebenz;Peruscabin;Scabagen;Scabanca;Scabiozon;Vanzoate;Scabide;benzylbenzoate;Benzyl benzenecarboxylate;Benzyl alcohol benzoic ester;Venzonate;Benzylester kyseliny benzoove;BENZOIC ACID PHENYLMETHYLESTER;FEMA No. 2138;NSC 8081;UNII-N863NB338G;MFCD00003075;CHEMBL1239;Antiscabiosum;CHEBI:41237;N863NB338G;NSC-8081;NCGC00094981-03;Peruscabina;Spasmodin;Benzyl benzoate, 99+%;Benzylis benzoas;DSSTox_CID_9153;Benzylum benzoicum;DSSTox_RID_78686;DSSTox_GSID_29153;Benzoesaeurebenzylester;Caswell No. 082;Benzylbenzenecarboxylate;Venzoate;Benzyl benzoate, analytical standard;Benzyl benzoate (natural);BZM;CAS-120-51-4;SMR000471875;HSDB 208;EINECS 204-402-9;Benzylester kyseliny benzoove [Czech];EPA Pesticide Chemical Code 009501;benzylbenzoat;BRN 2049280;Benzyl benzoate [USP:JAN];Acarobenzyl;Benzevan;Bengal;Benzoic acid phenylmethyl ester;AI3-00523;1dzm;Benylate (TN);benzoic acid benzyl;Spectrum_001240;Benzoic acid-benzyl ester;Spectrum2_000532;Spectrum3_001757;Spectrum4_000773;Spectrum5_001128;ACMC-1C8AP;WLN: RVO1R;Benzyl benzoate, >=99%;EC 204-402-9;SCHEMBL3038;BENZYL BENZOATE BP98;BSPBio_003494;KBioGR_001186;KBioSS_001720;4-09-00-00307 (Beilstein Handbook Reference);MLS001066412;MLS001336003;MLS001336004;DivK1c_000204;SPECTRUM1503002;SPBio_000543;Benzyl benzoate (JP17/USP);ZINC1021;DTXSID8029153;BENZOIC ACID,BENZYL ESTER;HMS500K06;KBio1_000204;KBio2_001720;KBio2_004288;KBio2_006856
;KBio3_002714;NSC8081;NINDS_000204;HMS1921P16;HMS2092F20;HMS2269D24;Pharmakon1600-01503002;HY-B0935;Tox21_111372;Tox21_201337;Tox21_303418;ANW-17509;BDBM50134035;CCG-39578;NSC758204;s4599;SBB058609;STL183088;AKOS003495939;Benzyl benzoate, >=99%, FCC, FG;Tox21_111372_1;DB00676;MCULE-4369643785;NSC-758204;IDI1_000204;Benzyl benzoate, for synthesis, 99.0%;NCGC00094981-01;NCGC00094981-02
258889-01;AC-17033;AK308304;SBI-0051748.P002;DB-041563;B0064;FT-0622708;ST50406335;Benzyl benzoate, natural, >=99%, FCC, FG;Benzyl benzoate, ReagentPlus(R), >=99.0%;Benzyl benzoate, SAJ first grade, >=98.0%;Benzyl benzoate, tested according to Ph.Eur.;A14577;A19449;Benzyl benzoate, SAJ special grade, >=99.0%;C12537;D01138;AB00052298_07;Benzyl benzoate, Vetec(TM) reagent grade, 98%;Benzyl benzoate;Q413755;SR-01000763773;Benzoic acid-benzyl ester 5000 microg/mL in Hexane;Q-200696;SR-01000763773-2;BRD-K52072429-001-06-1;Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester
Benzyl benzoate (BnBzO) is mediation and insect repellent. It is one of the older preparation used to treat scabies which is a skin infection caused by the mite Sarcoptes scabiei since it is lethal to the mite. It is capable of killing the mite in 5 minutes. It can also be used for the treatment of lice infestation of the head and the body. Its mechanism of action is through exerting a toxic effects on the nervous system of the insects, further causing its death. It is also toxic to mite ova through an unknown mechanism. It can also be used as a repellent for chiggers, ticks, and mosquitoes as well as a dye carrier, solvent of cellulose derivatives, plasticizer, and a fixative.
Uses
Medical
Benzyl benzoate is an effective and inexpensive topical treatment for human scabies. It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs. It is also used as an excipient in some testosterone-replacement medications (like Nebido) for treating hypogonadism.
Benzyl benzoate is used as a topical acaricide, scabicide, and pediculicide in veterinary hospitals.
Non-medical
Benzyl benzoate is used as a repellent for chiggers, ticks, and mosquitoes. It is also used as a dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.
Chemistry
It is an organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e. g. tuberose) and is a component of Balsam of Peru and Tolu balsam.
Production
Benzyl benzoate is produced industrially by the reaction of sodium benzoate with benzyl alcohol in the presence of a base, or by transesterification of methyl benzoate and benzyl alcohol. It is a byproduct of benzoic acid synthesis by toluene oxidation. It can also be synthesized by the Tishchenko reaction, using benzaldehyde with sodium benzilate (generated from sodium and benzyl alcohol) as a catalyst:
The Tishchenko reaction: benzaldehyde reacts to benzyl benzoate, the catalyst is sodium benzilate.
It occurs naturally in essential oils such as ylang-ylang, rosewood, cinnamon and benzoin.
When these essential oils are not used in a product, Benzyl Benzoate can be added in its synthetic form because of its amazing scent and excellent solvent properties. Indeed, it dissolves other perfume materials, allowing them to blend more easily.
What is Benzyl Benzoate?
Benzyl benzoate is a naturally occurring molecule found in some plants and is made up of benzyl alcohol and benzoic acid. In cosmetic products, it plays a number of roles depending on the product and it can act as a fragrance, a solvent, a plasticizer, a preservative, and a fixative.
How does it work?
As a fragrance, benzyl benzoate can add a balsamic smell to a product. It can also work with other fragrances as a solvent to help them dissolve into the mixture. Benzyl benzoate also acts as a fixative in perfumed products where it slows down the escape of other fragrances and increases the life span of the fragrance.
When added to more solid products like soaps, benzyl benzoate can act as a plasticizer. A plasticizer makes a product less brittle so a soap containing it can be bent and squished more before it snaps or crumbles.
Benzyl benzoate is used to treat lice and scabies infestations. This medicine is believed to be absorbed by the lice and mites and to destroy them by acting on their nervous system.
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite Sarcoptes scabiei. It is characterized by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body.
Mechanism of action
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Absorption
No data are available on the percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however, the amount was not quantified.
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Benzyl benzoate is a benzyl compound that can be synthesized by reacting benzyl chloride with sodium benzoate in the presence of tetrabutylaramonium iodide. It is reported to be the key constituent in the essential oils isolated from leaves and stem bark of Cinnamomum zeylanicum.
Benzyl benzoate, an ester of benzyl alcohol and benzoic acid, is widely used as a fragrance fixer, fragrance ingredient and preservative to maintain the potency and stability of a variety of cosmetic formulations. It is also employed as a synthetic musk, acaricide to treat scabies and headlice.
Benzyl Alcohol is an organic alcohol found in many fruits and teas. Benzyl Alcohol has a hydroxyl group, while the related compound, Benzoic Acid has a carboxyl group. Sodium Benzoate, Calcium Benzoate and Potassium Benzoate are salts of Benzoic Acid. Benzyl Benzoate is an ester of Benzyl Alcohol and Benzoic Acid.
Benzyl Alcohol, Benzoic Acid and its salts, and Benzyl Benzoate are used in a wide variety of cosmetics and personal care products, including baby products, bath products, soaps and detergents, eye makeup, blushers, cleansing products, makeup products, as well as hair, nail and skincare products.
Why is it used in cosmetics and personal care products?
The following functions have been reported for these ingredients.
Corrosion inhibitor - Sodium Benzoate
Fragrance ingredient - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Benzyl Benzoate
pH adjuster - Benzoic Acid
Preservative - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Calcium Benzoate, Potassium Benzoate
Solvent - Benzyl Alcohol, Benzyl Benzoate Viscosity decreasing agent - Benzyl Alcohol
Benzyl benzoate is a clear, colorless, oily liquid with a light, balsamic odor reminiscent of almond and a sharp, pungent taste. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃, it exists as clear, colorless crystals.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.
Contact allergens Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colorless liquid with a faint aromatic odor. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anesthetic effect; however, a complete cure is frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. This preparation has the additional advantage of being essentially odorless, nonstaining, and non-irritating to the skin. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide, and a plant metabolite. It is a benzyl ester and a benzoate ester. It derives from benzoic acid.
Mainly used as a non-agricultural pesticide with some veterinary applications as well as being used as a food additive and in perfumery.
Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma components of cranberry, mango, and Egyptian Jasminum sambac flowers.
It has a unique smell. It has an almond-like or balsamic scent. It is in a colorless solid or liquid form.
Boiling Point is 323.5 ° C.
Melting Point is 21 ° C.
Its solubility in water is almost negligible. It has a solubility of approximately 25 mg / L at 25 ° C.
It is insoluble in glycerin. Soluble in Ethyl Alcohol, Methyl Alcohol, Chloroform and Ethyl Ether.
Benzyl Benzoate density is 25 ° C 1.112 g / cm³.
It is a stable chemical compound in standard storage conditions.
Benzyl Benzoate Usage Areas:
• It is used in the creation of the oldest formulas used for the treatment of a skin disease called scabies. This is a skin infection. It is used to eliminate such skin infections.
• It is an ingredient used in the manufacture of drugs produced to inhibit ticks and mosquitoes.
• It is a chemical substance used as a solvent in many chemical substances.
• It is used as a solvent for cellulose substances.
• It is used as an essence in perfume production.
• It is used in the production of veterinary drugs, in chemicals produced for the treatment of skin diseases of animals.
• It is used as a sweetener in the Food Sector.
• It is used in the manufacture of pesticides for the treatment of dust settings in some textiles, carpets, mattresses and sofa upholstery and furniture.
Usage
It is one of the oldest anti-scabies drugs for both human and veterinary use. It is also used in combination with other agents against head lice and in skin protection creams.
It is also used as a solvent, as a fragrance ingredient in tobacco products, and to increase the plasticity of polymers and cellulose.
HOW BENZYL BENZOATE IS PRODUCED
Benzyl Benzoate is a naturally occurring molecule found in some plants (plant species of the genus Polyalthia) and consists of benzyl alcohol and benzoic acid. Benzyl benzoate was first studied medically in 1918.
It is a Benzoate ester obtained by formal condensation of Benzoic acid with Benzyl Alcohol. It can also be produced by the Tishchenko reaction, using benzaldehyde with sodium benzylate (produced from sodium and benzyl alcohol) as a catalyst.
BENZYL BENZOATE PHYSICAL AND CHEMICAL PROPERTIES
• Benzyl Benzoate is insoluble in water and glycerol. Soluble in ethanol, ethyl ether, acetone, benzene, methanol, chloroform.
• Benzyl Benzoate is stable under recommended storage conditions.
• Benzyl Benzoate, when heated to decompose, produces bitter and irritating fumes.
• It is in the form of a viscous liquid or solid flakes and has a weak balsamic odor.
Benzyl Benzoate has a high molecular weight, making it an extensively used fixative in the fine fragrance and perfume industry. It is used in topical pharmaceutical formulations for the treatment of lice and scabies. Additionally, Kalama Benzyl Benzoate is valued for its compatibility with candlewax, incorporating fragrance to fine candles while also promoting clean burning.
Treatment of scabies is with topical permethrin, benzyl benzoate, malathion,to its ir or oral ivermectin. The patient should apply 5% permethrin cream to the whole body, including the scalp, all folds, groin, navel, external genitalia, and skin under the nails, washing it off after 12 hours. In adults with classical scabies, treatment of the face is controversial, but in babies, the skin of the face should also be treated. A second application 7 days after the original treatment must be prescribed and all the affected members of a household require treatment at the same time to prevent cyclical reinfestations. Oral ivermectin is being increasingly used as a first-line treatment. Severe outbreaks require a second dose of ivermectin at a 2-week interval (200 µg/kg body weight). Treatment of secondary bacterial infection and antihistamines may be required. Washing clothes and linen at 60° C will kill all the young fecundated female mites (an alternative is to keep these in a plastic bag for 48-72 hours, as mites separated from the human host die within this time). It is important to explain that pruritus commonly lasts for several weeks after cure, which may be partially alleviated by non-sedating or sedating antihistamines.
Benzyl benzoate is used as an insecticide to kill scabies mites, dust mites, and ticks. It is also used as a plasticizer, a fixative in fragrances, a food additive, and a solvent. Dermatitis is the primary adverse reaction to its use as a topical solution. At high concentrations, it has been found to possess estrogenic properties and to stimulate the growth of human breast cells.
IDENTIFICATION:
Benzyl benzoate is a colorless oily liquid. It can also be in the form of leaflets. It has an almond taste and a pleasant odor. It is nearly insoluble in water. Benzyl benzoate occurs in many plants and essential oils.
USE:
Benzyl benzoate is an important commercial chemical. It is used in making plastics, as a solvent, in making other chemicals, as a food flavoring, and in perfumes. It is also used as a skin medication for humans and dogs in treating mites. Benzyl benzoate is used to control dust mites in carpets and furniture.
Industry Uses
•Dyes
•Odor agents
•Solvents (for cleaning and degreasing)
•Solvents (which become part of product formulation or mixture)
•Surface active agents
General Manufacturing Information
Industry Processing Sectors
•Air Care
•All other basic organic chemical manufacturing
•All other chemical product and preparation manufacturing
•Miscellaneous manufacturing
•Plastic material and resin manufacturing
•Soap, cleaning compound, and toilet preparation manufacturing
•Textiles, apparel, and leather manufacturing
•Fragrance
About this substance
Helpful information
This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
This substance is used in the following products: washing & cleaning products, polishes and waxes, air care products, cosmetics and personal care products, perfumes and fragrances and biocides (e.g. disinfectants, pest control products).
Another release to the environment of this substance is likely to occur from: indoor use as a processing aid and outdoor use as a processing aid.
Widespread uses by professional workers
This substance is used in the following products: polishes, washing & cleaning products, perfumes and fragrances and cosmetics and personal care products.
This substance is used in the following areas: health services and scientific research and development.
Another release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as a processing aid.
Formulation or re-packing
This substance is used in the following products: air care products, biocides (e.g. disinfectants, pest control products), leather treatment products, perfumes and fragrances, pharmaceuticals, photo-chemicals, polishes and waxes, polymers, textile treatment products and dyes, washing & cleaning products and cosmetics and personal care products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures.
Uses at industrial sites
This substance is used in the following products: washing & cleaning products, polymers, laboratory chemicals, air care products, coating products, perfumes and fragrances, polishes and waxes, textile treatment products and dyes and cosmetics and personal care products.
This substance has an industrial use resulting in the manufacture of another substance (use of intermediates).
This substance is used for the manufacture of chemicals, plastic products and textile, leather, or fur.
benzyl benzoate as a colorless, pleasant smell, taste very pungent oily liquid. The benzoic acid and benzyl alcohol ester. Insoluble in water, acetone and benzene soluble in alcohol, chloroform, ether blends, oils.
In nature, it occurs in gyömbérfélékhez belonging Kaempferia rotunda and Zingiber cassumunar the plant name.
Benzyl benzoate is a natural component of essential oils (for example jasmine, ylang-ylang, rosewood, cinnamon or benzoate). Benzyl benzoate can also be produced synthetically, but the effects do not differ. It occurs in the form of a colorless liquid or a white solid with a sweeter balsamic odor.
Benzyl benzoate is a stable substance, resistant to changes in temperature and environment, it is used as a stabilizer of fragrant compositions and the whole product. It masks the natural aroma of unscented ingredients, while also serving as a perfume thanks to its sweet balsamic scent. It also acts as a preservative and especially as a solvent (it dissolves other substances in the product). We find it in medicines to treat scabies (kills scabies mites), anti-lice preparations and insecticides. It has antimicrobial effects.
Occurrence
Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).
Uses
Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies, for example as a combination drug of benzyl benzoate/disulfiram.
It has other uses :
• a fixative in fragrances to improve the stability and other characteristics of the main ingredients
• a food additive in artificial flavours
• a plasticizer in cellulose and other polymers
• a solvent for various chemical reactions
• a treatment for sweet itch in horses
• a treatment for scaly leg mites in chickens.
Benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
As a solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.
Preparation
By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.
Production Methods
BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavours, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).
Indications
Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.
Taste threshold values
Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavours and perfumes in cosmetics and food products.
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colourless liquid with a faint aromatic odour. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anaesthetic effect; however, a complete cure is frequently achieved with a single application of a 25% emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate CAS 120-51-4 is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity has a slight fragrance. Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate is a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications to the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Benzyl Benzoate is a solvent. This means solutes such as Hormone Powders dissolve easily in it, and that is the main purpose of its use in Steroids. The Benzyl Benzoate is used to dissolve and suspend the Hormone Powder. If the correct amount of this solvent is not used the Hormone powder will 'undissolved from the solution causing the Steroids to 'Crash' (get cloudy/less effective).
Some Hormone Powder dissolves more easily than others and therefore less Benzyl Benzoate is required. The fact that varying amounts of solvent is required for the Hormone Powders is why having this page as a resource is so vital.
Benzyl Benzoate (BB) is the primary solvent, which keeps the product from is A co-solvent in steroid that serves several functions: helps dissolve the hormone, helps keep it in solution in depot (injection site), and thins the gear so it is easy to draw and inject.
Properties: In standard conditions, benzyl benzoate is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity would send out a slight fragrance.
Freezing point: ≥17°C
Boiling point: 323°C
Solubility: Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate itself, a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications in the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Applications:
Benzyl benzoate is mainly used in the area of textile auxiliary, fragrance and flavour, pharmacy, plasticizer and so on. Benzyl benzoate can be used as to lead agent, levelling agent and repair agent of textile auxiliaries. Mechanism: With the development of the textile industry, the materials are of a higher grade. The higher-grade cloth is, the more compact fabric is. So in dyeing, there are more difficulties in colouring and uniformity Due to the good plasticity performance, benzyl benzoate makes the fiber swell and undraw so that the fibre will be dyed easily. At the same time, benzyl benzoate is a good solvent to dissolve and disperse dye evenly. Since its quite good dye migration performance, benzyl benzoate could be developed as levelling agents and lead agents. There are many other materials, which have similar properties to benzyl benzoate, such as methylnaphthalene, dimethylnaphthalene, methyl salicylate, and benzene ester.
Benzyl benzoate is an organic compound that is used as a medication and insect repellent. As a medication, it is used to treat scabies and lice. For scabies either permethrin or malathion is typically preferred. It is applied to the skin as a lotion. Typically two to three applications are needed. It is also present in Balsam of Peru, Tolu balsam, and in a number of flowers. Benzyl benzoate was first studied medically in 1918. It is on the World Health Organization's List of Essential Medicines.
CAS NO: 120-51-4
EC NO: 204-402-9
IUPAC Names:
Benzil-benzoát
benzoic acid phenylmethyl ester
Benzoic acid, benzylester
BENZOIC ACID, PHENYL METHYL ESTER
Benzoic acid, phenylmethyl ester
Benzyl benxoate
BENZYL BENZOATE
Benzyl benzoate; Phenylmethyl benzoate
benzyl-2-methyl-hydroxybutyrate dehydrogenase
benzylbenzoate
phenylmethyl benzoate
SYNONYMS
Ascabiol; Novoscabin; Benylate; Scabitox; Scobenol; Ascabin; Benzoic acid benzyl ester; Benzyl phenylformate; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzoic acid phenylmethyl ester; Phenylmethyl benzoate; Antiscabiosum; Benzoic acid; benzyl ester; Benzyl benzenecarboxylate; Benzylis benzoas; Benzyl alcohol benzoic ester; Benzylbenzoate; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum;120-51-4;Ascabiol;Benzoic acid, phenylmethyl ester;Benzoic acid benzyl ester;Benylate;Novoscabin;Benzoic acid, benzyl ester;Ascabin;Scabitox;Scobenol;Benzyl phenylformate;Phenylmethyl benzoate;Benzylets;Colebenz;Peruscabin;Scabagen;Scabanca;Scabiozon;Vanzoate;Scabide;benzylbenzoate;Benzyl benzenecarboxylate;Benzyl alcohol benzoic ester;Venzonate;Benzylester kyseliny benzoove;BENZOIC ACID PHENYLMETHYLESTER;FEMA No. 2138;NSC 8081;UNII-N863NB338G;MFCD00003075;CHEMBL1239;Antiscabiosum;CHEBI:41237;N863NB338G;NSC-8081;NCGC00094981-03;Peruscabina;Spasmodin;Benzyl benzoate, 99+%;Benzylis benzoas;DSSTox_CID_9153;Benzylum benzoicum;DSSTox_RID_78686;DSSTox_GSID_29153;Benzoesaeurebenzylester;Caswell No. 082;Benzylbenzenecarboxylate;Venzoate;Benzyl benzoate, analytical standard;Benzyl benzoate (natural);BZM;CAS-120-51-4;SMR000471875;HSDB 208;EINECS 204-402-9;Benzylester kyseliny benzoove [Czech];EPA Pesticide Chemical Code 009501;benzylbenzoat;BRN 2049280;Benzyl benzoate [USP:JAN];Acarobenzyl;Benzevan;Bengal;Benzoic acid phenylmethyl ester;AI3-00523;1dzm;Benylate (TN);benzoic acid benzyl;Spectrum_001240;Benzoic acid-benzyl ester;Spectrum2_000532;Spectrum3_001757;Spectrum4_000773;Spectrum5_001128;ACMC-1C8AP;WLN: RVO1R;Benzyl benzoate, >=99%;EC 204-402-9;SCHEMBL3038;BENZYL BENZOATE BP98;BSPBio_003494;KBioGR_001186;KBioSS_001720;4-09-00-00307 (Beilstein Handbook Reference);MLS001066412;MLS001336003;MLS001336004;DivK1c_000204;SPECTRUM1503002;SPBio_000543;Benzyl benzoate (JP17/USP);ZINC1021;DTXSID8029153;BENZOIC ACID,BENZYL ESTER;HMS500K06;KBio1_000204;KBio2_001720;KBio2_004288;KBio2_006856
;KBio3_002714;NSC8081;NINDS_000204;HMS1921P16;HMS2092F20;HMS2269D24;Pharmakon1600-01503002;HY-B0935;Tox21_111372;Tox21_201337;Tox21_303418;ANW-17509;BDBM50134035;CCG-39578;NSC758204;s4599;SBB058609;STL183088;AKOS003495939;Benzyl benzoate, >=99%, FCC, FG;Tox21_111372_1;DB00676;MCULE-4369643785;NSC-758204;IDI1_000204;Benzyl benzoate, for synthesis, 99.0%;NCGC00094981-01;NCGC00094981-02
258889-01;AC-17033;AK308304;SBI-0051748.P002;DB-041563;B0064;FT-0622708;ST50406335;Benzyl benzoate, natural, >=99%, FCC, FG;Benzyl benzoate, ReagentPlus(R), >=99.0%;Benzyl benzoate, SAJ first grade, >=98.0%;Benzyl benzoate, tested according to Ph.Eur.;A14577;A19449;Benzyl benzoate, SAJ special grade, >=99.0%;C12537;D01138;AB00052298_07;Benzyl benzoate, Vetec(TM) reagent grade, 98%;Benzyl benzoate;Q413755;SR-01000763773;Benzoic acid-benzyl ester 5000 microg/mL in Hexane;Q-200696;SR-01000763773-2;BRD-K52072429-001-06-1;Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester
Benzyl benzoate (BnBzO) is mediation and insect repellent. It is one of the older preparation used to treat scabies which is a skin infection caused by the mite Sarcoptes scabiei since it is lethal to the mite. It is capable of killing the mite in 5 minutes. It can also be used for the treatment of lice infestation of the head and the body. Its mechanism of action is through exerting a toxic effects on the nervous system of the insects, further causing its death. It is also toxic to mite ova through an unknown mechanism. It can also be used as a repellent for chiggers, ticks, and mosquitoes as well as a dye carrier, solvent of cellulose derivatives, plasticizer, and a fixative.
Uses
Medical
Benzyl benzoate is an effective and inexpensive topical treatment for human scabies. It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs. It is also used as an excipient in some testosterone-replacement medications (like Nebido) for treating hypogonadism.
Benzyl benzoate is used as a topical acaricide, scabicide, and pediculicide in veterinary hospitals.
Non-medical
Benzyl benzoate is used as a repellent for chiggers, ticks, and mosquitoes. It is also used as a dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.
Chemistry
It is an organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e. g. tuberose) and is a component of Balsam of Peru and Tolu balsam.
Production
Benzyl benzoate is produced industrially by the reaction of sodium benzoate with benzyl alcohol in the presence of a base, or by transesterification of methyl benzoate and benzyl alcohol. It is a byproduct of benzoic acid synthesis by toluene oxidation. It can also be synthesized by the Tishchenko reaction, using benzaldehyde with sodium benzilate (generated from sodium and benzyl alcohol) as a catalyst:
The Tishchenko reaction: benzaldehyde reacts to benzyl benzoate, the catalyst is sodium benzilate.
It occurs naturally in essential oils such as ylang-ylang, rosewood, cinnamon and benzoin.
When these essential oils are not used in a product, Benzyl Benzoate can be added in its synthetic form because of its amazing scent and excellent solvent properties. Indeed, it dissolves other perfume materials, allowing them to blend more easily.
What is Benzyl Benzoate?
Benzyl benzoate is a naturally occurring molecule found in some plants and is made up of benzyl alcohol and benzoic acid. In cosmetic products, it plays a number of roles depending on the product and it can act as a fragrance, a solvent, a plasticizer, a preservative, and a fixative.
How does it work?
As a fragrance, benzyl benzoate can add a balsamic smell to a product. It can also work with other fragrances as a solvent to help them dissolve into the mixture. Benzyl benzoate also acts as a fixative in perfumed products where it slows down the escape of other fragrances and increases the life span of the fragrance.
When added to more solid products like soaps, benzyl benzoate can act as a plasticizer. A plasticizer makes a product less brittle so a soap containing it can be bent and squished more before it snaps or crumbles.
Benzyl benzoate is used to treat lice and scabies infestations. This medicine is believed to be absorbed by the lice and mites and to destroy them by acting on their nervous system.
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite Sarcoptes scabiei. It is characterized by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body.
Mechanism of action
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Absorption
No data are available on the percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however, the amount was not quantified.
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Benzyl benzoate is a benzyl compound that can be synthesized by reacting benzyl chloride with sodium benzoate in the presence of tetrabutylaramonium iodide. It is reported to be the key constituent in the essential oils isolated from leaves and stem bark of Cinnamomum zeylanicum.
Benzyl benzoate, an ester of benzyl alcohol and benzoic acid, is widely used as a fragrance fixer, fragrance ingredient and preservative to maintain the potency and stability of a variety of cosmetic formulations. It is also employed as a synthetic musk, acaricide to treat scabies and headlice.
Benzyl Alcohol is an organic alcohol found in many fruits and teas. Benzyl Alcohol has a hydroxyl group, while the related compound, Benzoic Acid has a carboxyl group. Sodium Benzoate, Calcium Benzoate and Potassium Benzoate are salts of Benzoic Acid. Benzyl Benzoate is an ester of Benzyl Alcohol and Benzoic Acid.
Benzyl Alcohol, Benzoic Acid and its salts, and Benzyl Benzoate are used in a wide variety of cosmetics and personal care products, including baby products, bath products, soaps and detergents, eye makeup, blushers, cleansing products, makeup products, as well as hair, nail and skincare products.
Why is it used in cosmetics and personal care products?
The following functions have been reported for these ingredients.
Corrosion inhibitor - Sodium Benzoate
Fragrance ingredient - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Benzyl Benzoate
pH adjuster - Benzoic Acid
Preservative - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Calcium Benzoate, Potassium Benzoate
Solvent - Benzyl Alcohol, Benzyl Benzoate Viscosity decreasing agent - Benzyl Alcohol
Benzyl benzoate is a clear, colorless, oily liquid with a light, balsamic odor reminiscent of almond and a sharp, pungent taste. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃, it exists as clear, colorless crystals.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.
Contact allergens Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colorless liquid with a faint aromatic odor. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anesthetic effect; however, a complete cure is frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. This preparation has the additional advantage of being essentially odorless, nonstaining, and non-irritating to the skin. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide, and a plant metabolite. It is a benzyl ester and a benzoate ester. It derives from benzoic acid.
Mainly used as a non-agricultural pesticide with some veterinary applications as well as being used as a food additive and in perfumery.
Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma components of cranberry, mango, and Egyptian Jasminum sambac flowers.
It has a unique smell. It has an almond-like or balsamic scent. It is in a colorless solid or liquid form.
Boiling Point is 323.5 ° C.
Melting Point is 21 ° C.
Its solubility in water is almost negligible. It has a solubility of approximately 25 mg / L at 25 ° C.
It is insoluble in glycerin. Soluble in Ethyl Alcohol, Methyl Alcohol, Chloroform and Ethyl Ether.
Benzyl Benzoate density is 25 ° C 1.112 g / cm³.
It is a stable chemical compound in standard storage conditions.
Benzyl Benzoate Usage Areas:
• It is used in the creation of the oldest formulas used for the treatment of a skin disease called scabies. This is a skin infection. It is used to eliminate such skin infections.
• It is an ingredient used in the manufacture of drugs produced to inhibit ticks and mosquitoes.
• It is a chemical substance used as a solvent in many chemical substances.
• It is used as a solvent for cellulose substances.
• It is used as an essence in perfume production.
• It is used in the production of veterinary drugs, in chemicals produced for the treatment of skin diseases of animals.
• It is used as a sweetener in the Food Sector.
• It is used in the manufacture of pesticides for the treatment of dust settings in some textiles, carpets, mattresses and sofa upholstery and furniture.
Usage
It is one of the oldest anti-scabies drugs for both human and veterinary use. It is also used in combination with other agents against head lice and in skin protection creams.
It is also used as a solvent, as a fragrance ingredient in tobacco products, and to increase the plasticity of polymers and cellulose.
HOW BENZYL BENZOATE IS PRODUCED
Benzyl Benzoate is a naturally occurring molecule found in some plants (plant species of the genus Polyalthia) and consists of benzyl alcohol and benzoic acid. Benzyl benzoate was first studied medically in 1918.
It is a Benzoate ester obtained by formal condensation of Benzoic acid with Benzyl Alcohol. It can also be produced by the Tishchenko reaction, using benzaldehyde with sodium benzylate (produced from sodium and benzyl alcohol) as a catalyst.
BENZYL BENZOATE PHYSICAL AND CHEMICAL PROPERTIES
• Benzyl Benzoate is insoluble in water and glycerol. Soluble in ethanol, ethyl ether, acetone, benzene, methanol, chloroform.
• Benzyl Benzoate is stable under recommended storage conditions.
• Benzyl Benzoate, when heated to decompose, produces bitter and irritating fumes.
• It is in the form of a viscous liquid or solid flakes and has a weak balsamic odor.
Benzyl Benzoate has a high molecular weight, making it an extensively used fixative in the fine fragrance and perfume industry. It is used in topical pharmaceutical formulations for the treatment of lice and scabies. Additionally, Kalama Benzyl Benzoate is valued for its compatibility with candlewax, incorporating fragrance to fine candles while also promoting clean burning.
Treatment of scabies is with topical permethrin, benzyl benzoate, malathion,to its ir or oral ivermectin. The patient should apply 5% permethrin cream to the whole body, including the scalp, all folds, groin, navel, external genitalia, and skin under the nails, washing it off after 12 hours. In adults with classical scabies, treatment of the face is controversial, but in babies, the skin of the face should also be treated. A second application 7 days after the original treatment must be prescribed and all the affected members of a household require treatment at the same time to prevent cyclical reinfestations. Oral ivermectin is being increasingly used as a first-line treatment. Severe outbreaks require a second dose of ivermectin at a 2-week interval (200 µg/kg body weight). Treatment of secondary bacterial infection and antihistamines may be required. Washing clothes and linen at 60° C will kill all the young fecundated female mites (an alternative is to keep these in a plastic bag for 48-72 hours, as mites separated from the human host die within this time). It is important to explain that pruritus commonly lasts for several weeks after cure, which may be partially alleviated by non-sedating or sedating antihistamines.
Benzyl benzoate is used as an insecticide to kill scabies mites, dust mites, and ticks. It is also used as a plasticizer, a fixative in fragrances, a food additive, and a solvent. Dermatitis is the primary adverse reaction to its use as a topical solution. At high concentrations, it has been found to possess estrogenic properties and to stimulate the growth of human breast cells.
IDENTIFICATION:
Benzyl benzoate is a colorless oily liquid. It can also be in the form of leaflets. It has an almond taste and a pleasant odor. It is nearly insoluble in water. Benzyl benzoate occurs in many plants and essential oils.
USE:
Benzyl benzoate is an important commercial chemical. It is used in making plastics, as a solvent, in making other chemicals, as a food flavoring, and in perfumes. It is also used as a skin medication for humans and dogs in treating mites. Benzyl benzoate is used to control dust mites in carpets and furniture.
Industry Uses
•Dyes
•Odor agents
•Solvents (for cleaning and degreasing)
•Solvents (which become part of product formulation or mixture)
•Surface active agents
General Manufacturing Information
Industry Processing Sectors
•Air Care
•All other basic organic chemical manufacturing
•All other chemical product and preparation manufacturing
•Miscellaneous manufacturing
•Plastic material and resin manufacturing
•Soap, cleaning compound, and toilet preparation manufacturing
•Textiles, apparel, and leather manufacturing
•Fragrance
About this substance
Helpful information
This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
This substance is used in the following products: washing & cleaning products, polishes and waxes, air care products, cosmetics and personal care products, perfumes and fragrances and biocides (e.g. disinfectants, pest control products).
Another release to the environment of this substance is likely to occur from: indoor use as a processing aid and outdoor use as a processing aid.
Widespread uses by professional workers
This substance is used in the following products: polishes, washing & cleaning products, perfumes and fragrances and cosmetics and personal care products.
This substance is used in the following areas: health services and scientific research and development.
Another release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as a processing aid.
Formulation or re-packing
This substance is used in the following products: air care products, biocides (e.g. disinfectants, pest control products), leather treatment products, perfumes and fragrances, pharmaceuticals, photo-chemicals, polishes and waxes, polymers, textile treatment products and dyes, washing & cleaning products and cosmetics and personal care products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures.
Uses at industrial sites
This substance is used in the following products: washing & cleaning products, polymers, laboratory chemicals, air care products, coating products, perfumes and fragrances, polishes and waxes, textile treatment products and dyes and cosmetics and personal care products.
This substance has an industrial use resulting in the manufacture of another substance (use of intermediates).
This substance is used for the manufacture of chemicals, plastic products and textile, leather, or fur.
benzyl benzoate as a colorless, pleasant smell, taste very pungent oily liquid. The benzoic acid and benzyl alcohol ester. Insoluble in water, acetone and benzene soluble in alcohol, chloroform, ether blends, oils.
In nature, it occurs in gyömbérfélékhez belonging Kaempferia rotunda and Zingiber cassumunar the plant name.
Benzyl benzoate is a natural component of essential oils (for example jasmine, ylang-ylang, rosewood, cinnamon or benzoate). Benzyl benzoate can also be produced synthetically, but the effects do not differ. It occurs in the form of a colorless liquid or a white solid with a sweeter balsamic odor.
Benzyl benzoate is a stable substance, resistant to changes in temperature and environment, it is used as a stabilizer of fragrant compositions and the whole product. It masks the natural aroma of unscented ingredients, while also serving as a perfume thanks to its sweet balsamic scent. It also acts as a preservative and especially as a solvent (it dissolves other substances in the product). We find it in medicines to treat scabies (kills scabies mites), anti-lice preparations and insecticides. It has antimicrobial effects.
Occurrence
Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).
Uses
Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies, for example as a combination drug of benzyl benzoate/disulfiram.
It has other uses :
• a fixative in fragrances to improve the stability and other characteristics of the main ingredients
• a food additive in artificial flavours
• a plasticizer in cellulose and other polymers
• a solvent for various chemical reactions
• a treatment for sweet itch in horses
• a treatment for scaly leg mites in chickens.
Benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
As a solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.
Preparation
By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.
Production Methods
BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavours, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).
Indications
Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.
Taste threshold values
Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavours and perfumes in cosmetics and food products.
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colourless liquid with a faint aromatic odour. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anaesthetic effect; however, a complete cure is frequently achieved with a single application of a 25% emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate CAS 120-51-4 is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity has a slight fragrance. Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate is a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications to the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Benzyl Benzoate is a solvent. This means solutes such as Hormone Powders dissolve easily in it, and that is the main purpose of its use in Steroids. The Benzyl Benzoate is used to dissolve and suspend the Hormone Powder. If the correct amount of this solvent is not used the Hormone powder will 'undissolved from the solution causing the Steroids to 'Crash' (get cloudy/less effective).
Some Hormone Powder dissolves more easily than others and therefore less Benzyl Benzoate is required. The fact that varying amounts of solvent is required for the Hormone Powders is why having this page as a resource is so vital.
Benzyl Benzoate (BB) is the primary solvent, which keeps the product from is A co-solvent in steroid that serves several functions: helps dissolve the hormone, helps keep it in solution in depot (injection site), and thins the gear so it is easy to draw and inject.
Properties: In standard conditions, benzyl benzoate is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity would send out a slight fragrance.
Freezing point: ≥17°C
Boiling point: 323°C
Solubility: Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate itself, a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications in the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Applications:
Benzyl benzoate is mainly used in the area of textile auxiliary, fragrance and flavour, pharmacy, plasticizer and so on. Benzyl benzoate can be used as to lead agent, levelling agent and repair agent of textile auxiliaries. Mechanism: With the development of the textile industry, the materials are of a higher grade. The higher-grade cloth is, the more compact fabric is. So in dyeing, there are more difficulties in colouring and uniformity Due to the good plasticity performance, benzyl benzoate makes the fiber swell and undraw so that the fibre will be dyed easily. At the same time, benzyl benzoate is a good solvent to dissolve and disperse dye evenly. Since its quite good dye migration performance, benzyl benzoate could be developed as levelling agents and lead agents. There are many other materials, which have similar properties to benzyl benzoate, such as methylnaphthalene, dimethylnaphthalene, methyl salicylate, and benzene ester.
