Benzyl benzoate is an organic compound that is used as a medication and insect repellent. As a medication, it is used to treat scabies and lice. For scabies either permethrin or malathion is typically preferred. It is applied to the skin as a lotion. Typically two to three applications are needed. It is also present in Balsam of Peru, Tolu balsam, and in a number of flowers. Benzyl benzoate was first studied medically in 1918. It is on the World Health Organization's List of Essential Medicines.
CAS NO: 120-51-4
EC NO: 204-402-9
IUPAC Names:
Benzil-benzoát
benzoic acid phenylmethyl ester
Benzoic acid, benzylester
BENZOIC ACID, PHENYL METHYL ESTER
Benzoic acid, phenylmethyl ester
Benzyl benxoate
BENZYL BENZOATE
Benzyl benzoate; Phenylmethyl benzoate
benzyl-2-methyl-hydroxybutyrate dehydrogenase
benzylbenzoate
phenylmethyl benzoate
SYNONYMS
Ascabiol; Novoscabin; Benylate; Scabitox; Scobenol; Ascabin; Benzoic acid benzyl ester; Benzyl phenylformate; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzoic acid phenylmethyl ester; Phenylmethyl benzoate; Antiscabiosum; Benzoic acid; benzyl ester; Benzyl benzenecarboxylate; Benzylis benzoas; Benzyl alcohol benzoic ester; Benzylbenzoate; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum;120-51-4;Ascabiol;Benzoic acid, phenylmethyl ester;Benzoic acid benzyl ester;Benylate;Novoscabin;Benzoic acid, benzyl ester;Ascabin;Scabitox;Scobenol;Benzyl phenylformate;Phenylmethyl benzoate;Benzylets;Colebenz;Peruscabin;Scabagen;Scabanca;Scabiozon;Vanzoate;Scabide;benzylbenzoate;Benzyl benzenecarboxylate;Benzyl alcohol benzoic ester;Venzonate;Benzylester kyseliny benzoove;BENZOIC ACID PHENYLMETHYLESTER;FEMA No. 2138;NSC 8081;UNII-N863NB338G;MFCD00003075;CHEMBL1239;Antiscabiosum;CHEBI:41237;N863NB338G;NSC-8081;NCGC00094981-03;Peruscabina;Spasmodin;Benzyl benzoate, 99+%;Benzylis benzoas;DSSTox_CID_9153;Benzylum benzoicum;DSSTox_RID_78686;DSSTox_GSID_29153;Benzoesaeurebenzylester;Caswell No. 082;Benzylbenzenecarboxylate;Venzoate;Benzyl benzoate, analytical standard;Benzyl benzoate (natural);BZM;CAS-120-51-4;SMR000471875;HSDB 208;EINECS 204-402-9;Benzylester kyseliny benzoove [Czech];EPA Pesticide Chemical Code 009501;benzylbenzoat;BRN 2049280;Benzyl benzoate [USP:JAN];Acarobenzyl;Benzevan;Bengal;Benzoic acid phenylmethyl ester;AI3-00523;1dzm;Benylate (TN);benzoic acid benzyl;Spectrum_001240;Benzoic acid-benzyl ester;Spectrum2_000532;Spectrum3_001757;Spectrum4_000773;Spectrum5_001128;ACMC-1C8AP;WLN: RVO1R;Benzyl benzoate, >=99%;EC 204-402-9;SCHEMBL3038;BENZYL BENZOATE BP98;BSPBio_003494;KBioGR_001186;KBioSS_001720;4-09-00-00307 (Beilstein Handbook Reference);MLS001066412;MLS001336003;MLS001336004;DivK1c_000204;SPECTRUM1503002;SPBio_000543;Benzyl benzoate (JP17/USP);ZINC1021;DTXSID8029153;BENZOIC ACID,BENZYL ESTER;HMS500K06;KBio1_000204;KBio2_001720;KBio2_004288;KBio2_006856
;KBio3_002714;NSC8081;NINDS_000204;HMS1921P16;HMS2092F20;HMS2269D24;Pharmakon1600-01503002;HY-B0935;Tox21_111372;Tox21_201337;Tox21_303418;ANW-17509;BDBM50134035;CCG-39578;NSC758204;s4599;SBB058609;STL183088;AKOS003495939;Benzyl benzoate, >=99%, FCC, FG;Tox21_111372_1;DB00676;MCULE-4369643785;NSC-758204;IDI1_000204;Benzyl benzoate, for synthesis, 99.0%;NCGC00094981-01;NCGC00094981-02
258889-01;AC-17033;AK308304;SBI-0051748.P002;DB-041563;B0064;FT-0622708;ST50406335;Benzyl benzoate, natural, >=99%, FCC, FG;Benzyl benzoate, ReagentPlus(R), >=99.0%;Benzyl benzoate, SAJ first grade, >=98.0%;Benzyl benzoate, tested according to Ph.Eur.;A14577;A19449;Benzyl benzoate, SAJ special grade, >=99.0%;C12537;D01138;AB00052298_07;Benzyl benzoate, Vetec(TM) reagent grade, 98%;Benzyl benzoate;Q413755;SR-01000763773;Benzoic acid-benzyl ester 5000 microg/mL in Hexane;Q-200696;SR-01000763773-2;BRD-K52072429-001-06-1;Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester
Benzyl benzoate (BnBzO) is mediation and insect repellent. It is one of the older preparation used to treat scabies which is a skin infection caused by the mite Sarcoptes scabiei since it is lethal to the mite. It is capable of killing the mite in 5 minutes. It can also be used for the treatment of lice infestation of the head and the body. Its mechanism of action is through exerting a toxic effects on the nervous system of the insects, further causing its death. It is also toxic to mite ova through an unknown mechanism. It can also be used as a repellent for chiggers, ticks, and mosquitoes as well as a dye carrier, solvent of cellulose derivatives, plasticizer, and a fixative.
Uses
Medical
Benzyl benzoate is an effective and inexpensive topical treatment for human scabies. It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs. It is also used as an excipient in some testosterone-replacement medications (like Nebido) for treating hypogonadism.
Benzyl benzoate is used as a topical acaricide, scabicide, and pediculicide in veterinary hospitals.
Non-medical
Benzyl benzoate is used as a repellent for chiggers, ticks, and mosquitoes. It is also used as a dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.
Chemistry
It is an organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e. g. tuberose) and is a component of Balsam of Peru and Tolu balsam.
Production
Benzyl benzoate is produced industrially by the reaction of sodium benzoate with benzyl alcohol in the presence of a base, or by transesterification of methyl benzoate and benzyl alcohol. It is a byproduct of benzoic acid synthesis by toluene oxidation. It can also be synthesized by the Tishchenko reaction, using benzaldehyde with sodium benzilate (generated from sodium and benzyl alcohol) as a catalyst:
The Tishchenko reaction: benzaldehyde reacts to benzyl benzoate, the catalyst is sodium benzilate.
It occurs naturally in essential oils such as ylang-ylang, rosewood, cinnamon and benzoin.
When these essential oils are not used in a product, Benzyl Benzoate can be added in its synthetic form because of its amazing scent and excellent solvent properties. Indeed, it dissolves other perfume materials, allowing them to blend more easily.
What is Benzyl Benzoate?
Benzyl benzoate is a naturally occurring molecule found in some plants and is made up of benzyl alcohol and benzoic acid. In cosmetic products, it plays a number of roles depending on the product and it can act as a fragrance, a solvent, a plasticizer, a preservative, and a fixative.
How does it work?
As a fragrance, benzyl benzoate can add a balsamic smell to a product. It can also work with other fragrances as a solvent to help them dissolve into the mixture. Benzyl benzoate also acts as a fixative in perfumed products where it slows down the escape of other fragrances and increases the life span of the fragrance.
When added to more solid products like soaps, benzyl benzoate can act as a plasticizer. A plasticizer makes a product less brittle so a soap containing it can be bent and squished more before it snaps or crumbles.
Benzyl benzoate is used to treat lice and scabies infestations. This medicine is believed to be absorbed by the lice and mites and to destroy them by acting on their nervous system.
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite Sarcoptes scabiei. It is characterized by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body.
Mechanism of action
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Absorption
No data are available on the percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however, the amount was not quantified.
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Benzyl benzoate is a benzyl compound that can be synthesized by reacting benzyl chloride with sodium benzoate in the presence of tetrabutylaramonium iodide. It is reported to be the key constituent in the essential oils isolated from leaves and stem bark of Cinnamomum zeylanicum.
Benzyl benzoate, an ester of benzyl alcohol and benzoic acid, is widely used as a fragrance fixer, fragrance ingredient and preservative to maintain the potency and stability of a variety of cosmetic formulations. It is also employed as a synthetic musk, acaricide to treat scabies and headlice.
Benzyl Alcohol is an organic alcohol found in many fruits and teas. Benzyl Alcohol has a hydroxyl group, while the related compound, Benzoic Acid has a carboxyl group. Sodium Benzoate, Calcium Benzoate and Potassium Benzoate are salts of Benzoic Acid. Benzyl Benzoate is an ester of Benzyl Alcohol and Benzoic Acid.
Benzyl Alcohol, Benzoic Acid and its salts, and Benzyl Benzoate are used in a wide variety of cosmetics and personal care products, including baby products, bath products, soaps and detergents, eye makeup, blushers, cleansing products, makeup products, as well as hair, nail and skincare products.
Why is it used in cosmetics and personal care products?
The following functions have been reported for these ingredients.
Corrosion inhibitor - Sodium Benzoate
Fragrance ingredient - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Benzyl Benzoate
pH adjuster - Benzoic Acid
Preservative - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Calcium Benzoate, Potassium Benzoate
Solvent - Benzyl Alcohol, Benzyl Benzoate Viscosity decreasing agent - Benzyl Alcohol
Benzyl benzoate is a clear, colorless, oily liquid with a light, balsamic odor reminiscent of almond and a sharp, pungent taste. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃, it exists as clear, colorless crystals.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.
Contact allergens Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colorless liquid with a faint aromatic odor. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anesthetic effect; however, a complete cure is frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. This preparation has the additional advantage of being essentially odorless, nonstaining, and non-irritating to the skin. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide, and a plant metabolite. It is a benzyl ester and a benzoate ester. It derives from benzoic acid.
Mainly used as a non-agricultural pesticide with some veterinary applications as well as being used as a food additive and in perfumery.
Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma components of cranberry, mango, and Egyptian Jasminum sambac flowers.
It has a unique smell. It has an almond-like or balsamic scent. It is in a colorless solid or liquid form.
Boiling Point is 323.5 ° C.
Melting Point is 21 ° C.
Its solubility in water is almost negligible. It has a solubility of approximately 25 mg / L at 25 ° C.
It is insoluble in glycerin. Soluble in Ethyl Alcohol, Methyl Alcohol, Chloroform and Ethyl Ether.
Benzyl Benzoate density is 25 ° C 1.112 g / cm³.
It is a stable chemical compound in standard storage conditions.
Benzyl Benzoate Usage Areas:
• It is used in the creation of the oldest formulas used for the treatment of a skin disease called scabies. This is a skin infection. It is used to eliminate such skin infections.
• It is an ingredient used in the manufacture of drugs produced to inhibit ticks and mosquitoes.
• It is a chemical substance used as a solvent in many chemical substances.
• It is used as a solvent for cellulose substances.
• It is used as an essence in perfume production.
• It is used in the production of veterinary drugs, in chemicals produced for the treatment of skin diseases of animals.
• It is used as a sweetener in the Food Sector.
• It is used in the manufacture of pesticides for the treatment of dust settings in some textiles, carpets, mattresses and sofa upholstery and furniture.
Usage
It is one of the oldest anti-scabies drugs for both human and veterinary use. It is also used in combination with other agents against head lice and in skin protection creams.
It is also used as a solvent, as a fragrance ingredient in tobacco products, and to increase the plasticity of polymers and cellulose.
HOW BENZYL BENZOATE IS PRODUCED
Benzyl Benzoate is a naturally occurring molecule found in some plants (plant species of the genus Polyalthia) and consists of benzyl alcohol and benzoic acid. Benzyl benzoate was first studied medically in 1918.
It is a Benzoate ester obtained by formal condensation of Benzoic acid with Benzyl Alcohol. It can also be produced by the Tishchenko reaction, using benzaldehyde with sodium benzylate (produced from sodium and benzyl alcohol) as a catalyst.
BENZYL BENZOATE PHYSICAL AND CHEMICAL PROPERTIES
• Benzyl Benzoate is insoluble in water and glycerol. Soluble in ethanol, ethyl ether, acetone, benzene, methanol, chloroform.
• Benzyl Benzoate is stable under recommended storage conditions.
• Benzyl Benzoate, when heated to decompose, produces bitter and irritating fumes.
• It is in the form of a viscous liquid or solid flakes and has a weak balsamic odor.
Benzyl Benzoate has a high molecular weight, making it an extensively used fixative in the fine fragrance and perfume industry. It is used in topical pharmaceutical formulations for the treatment of lice and scabies. Additionally, Kalama Benzyl Benzoate is valued for its compatibility with candlewax, incorporating fragrance to fine candles while also promoting clean burning.
Treatment of scabies is with topical permethrin, benzyl benzoate, malathion,to its ir or oral ivermectin. The patient should apply 5% permethrin cream to the whole body, including the scalp, all folds, groin, navel, external genitalia, and skin under the nails, washing it off after 12 hours. In adults with classical scabies, treatment of the face is controversial, but in babies, the skin of the face should also be treated. A second application 7 days after the original treatment must be prescribed and all the affected members of a household require treatment at the same time to prevent cyclical reinfestations. Oral ivermectin is being increasingly used as a first-line treatment. Severe outbreaks require a second dose of ivermectin at a 2-week interval (200 µg/kg body weight). Treatment of secondary bacterial infection and antihistamines may be required. Washing clothes and linen at 60° C will kill all the young fecundated female mites (an alternative is to keep these in a plastic bag for 48-72 hours, as mites separated from the human host die within this time). It is important to explain that pruritus commonly lasts for several weeks after cure, which may be partially alleviated by non-sedating or sedating antihistamines.
Benzyl benzoate is used as an insecticide to kill scabies mites, dust mites, and ticks. It is also used as a plasticizer, a fixative in fragrances, a food additive, and a solvent. Dermatitis is the primary adverse reaction to its use as a topical solution. At high concentrations, it has been found to possess estrogenic properties and to stimulate the growth of human breast cells.
IDENTIFICATION:
Benzyl benzoate is a colorless oily liquid. It can also be in the form of leaflets. It has an almond taste and a pleasant odor. It is nearly insoluble in water. Benzyl benzoate occurs in many plants and essential oils.
USE:
Benzyl benzoate is an important commercial chemical. It is used in making plastics, as a solvent, in making other chemicals, as a food flavoring, and in perfumes. It is also used as a skin medication for humans and dogs in treating mites. Benzyl benzoate is used to control dust mites in carpets and furniture.
Industry Uses
•Dyes
•Odor agents
•Solvents (for cleaning and degreasing)
•Solvents (which become part of product formulation or mixture)
•Surface active agents
General Manufacturing Information
Industry Processing Sectors
•Air Care
•All other basic organic chemical manufacturing
•All other chemical product and preparation manufacturing
•Miscellaneous manufacturing
•Plastic material and resin manufacturing
•Soap, cleaning compound, and toilet preparation manufacturing
•Textiles, apparel, and leather manufacturing
•Fragrance
About this substance
Helpful information
This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
This substance is used in the following products: washing & cleaning products, polishes and waxes, air care products, cosmetics and personal care products, perfumes and fragrances and biocides (e.g. disinfectants, pest control products).
Another release to the environment of this substance is likely to occur from: indoor use as a processing aid and outdoor use as a processing aid.
Widespread uses by professional workers
This substance is used in the following products: polishes, washing & cleaning products, perfumes and fragrances and cosmetics and personal care products.
This substance is used in the following areas: health services and scientific research and development.
Another release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as a processing aid.
Formulation or re-packing
This substance is used in the following products: air care products, biocides (e.g. disinfectants, pest control products), leather treatment products, perfumes and fragrances, pharmaceuticals, photo-chemicals, polishes and waxes, polymers, textile treatment products and dyes, washing & cleaning products and cosmetics and personal care products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures.
Uses at industrial sites
This substance is used in the following products: washing & cleaning products, polymers, laboratory chemicals, air care products, coating products, perfumes and fragrances, polishes and waxes, textile treatment products and dyes and cosmetics and personal care products.
This substance has an industrial use resulting in the manufacture of another substance (use of intermediates).
This substance is used for the manufacture of chemicals, plastic products and textile, leather, or fur.
benzyl benzoate as a colorless, pleasant smell, taste very pungent oily liquid. The benzoic acid and benzyl alcohol ester. Insoluble in water, acetone and benzene soluble in alcohol, chloroform, ether blends, oils.
In nature, it occurs in gyömbérfélékhez belonging Kaempferia rotunda and Zingiber cassumunar the plant name.
Benzyl benzoate is a natural component of essential oils (for example jasmine, ylang-ylang, rosewood, cinnamon or benzoate). Benzyl benzoate can also be produced synthetically, but the effects do not differ. It occurs in the form of a colorless liquid or a white solid with a sweeter balsamic odor.
Benzyl benzoate is a stable substance, resistant to changes in temperature and environment, it is used as a stabilizer of fragrant compositions and the whole product. It masks the natural aroma of unscented ingredients, while also serving as a perfume thanks to its sweet balsamic scent. It also acts as a preservative and especially as a solvent (it dissolves other substances in the product). We find it in medicines to treat scabies (kills scabies mites), anti-lice preparations and insecticides. It has antimicrobial effects.
Occurrence
Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).
Uses
Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies, for example as a combination drug of benzyl benzoate/disulfiram.
It has other uses :
• a fixative in fragrances to improve the stability and other characteristics of the main ingredients
• a food additive in artificial flavours
• a plasticizer in cellulose and other polymers
• a solvent for various chemical reactions
• a treatment for sweet itch in horses
• a treatment for scaly leg mites in chickens.
Benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
As a solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.
Preparation
By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.
Production Methods
BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavours, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).
Indications
Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.
Taste threshold values
Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavours and perfumes in cosmetics and food products.
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colourless liquid with a faint aromatic odour. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anaesthetic effect; however, a complete cure is frequently achieved with a single application of a 25% emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate CAS 120-51-4 is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity has a slight fragrance. Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate is a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications to the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Benzyl Benzoate is a solvent. This means solutes such as Hormone Powders dissolve easily in it, and that is the main purpose of its use in Steroids. The Benzyl Benzoate is used to dissolve and suspend the Hormone Powder. If the correct amount of this solvent is not used the Hormone powder will 'undissolved from the solution causing the Steroids to 'Crash' (get cloudy/less effective).
Some Hormone Powder dissolves more easily than others and therefore less Benzyl Benzoate is required. The fact that varying amounts of solvent is required for the Hormone Powders is why having this page as a resource is so vital.
Benzyl Benzoate (BB) is the primary solvent, which keeps the product from is A co-solvent in steroid that serves several functions: helps dissolve the hormone, helps keep it in solution in depot (injection site), and thins the gear so it is easy to draw and inject.
Properties: In standard conditions, benzyl benzoate is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity would send out a slight fragrance.
Freezing point: ≥17°C
Boiling point: 323°C
Solubility: Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate itself, a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications in the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Applications:
Benzyl benzoate is mainly used in the area of textile auxiliary, fragrance and flavour, pharmacy, plasticizer and so on. Benzyl benzoate can be used as to lead agent, levelling agent and repair agent of textile auxiliaries. Mechanism: With the development of the textile industry, the materials are of a higher grade. The higher-grade cloth is, the more compact fabric is. So in dyeing, there are more difficulties in colouring and uniformity Due to the good plasticity performance, benzyl benzoate makes the fiber swell and undraw so that the fibre will be dyed easily. At the same time, benzyl benzoate is a good solvent to dissolve and disperse dye evenly. Since its quite good dye migration performance, benzyl benzoate could be developed as levelling agents and lead agents. There are many other materials, which have similar properties to benzyl benzoate, such as methylnaphthalene, dimethylnaphthalene, methyl salicylate, and benzene ester.
Benzyl benzoate is an organic compound that is used as a medication and insect repellent. As a medication, it is used to treat scabies and lice. For scabies either permethrin or malathion is typically preferred. It is applied to the skin as a lotion. Typically two to three applications are needed. It is also present in Balsam of Peru, Tolu balsam, and in a number of flowers. Benzyl benzoate was first studied medically in 1918. It is on the World Health Organization's List of Essential Medicines.
CAS NO: 120-51-4
EC NO: 204-402-9
IUPAC Names:
Benzil-benzoát
benzoic acid phenylmethyl ester
Benzoic acid, benzylester
BENZOIC ACID, PHENYL METHYL ESTER
Benzoic acid, phenylmethyl ester
Benzyl benxoate
BENZYL BENZOATE
Benzyl benzoate; Phenylmethyl benzoate
benzyl-2-methyl-hydroxybutyrate dehydrogenase
benzylbenzoate
phenylmethyl benzoate
SYNONYMS
Ascabiol; Novoscabin; Benylate; Scabitox; Scobenol; Ascabin; Benzoic acid benzyl ester; Benzyl phenylformate; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzoic acid phenylmethyl ester; Phenylmethyl benzoate; Antiscabiosum; Benzoic acid; benzyl ester; Benzyl benzenecarboxylate; Benzylis benzoas; Benzyl alcohol benzoic ester; Benzylbenzoate; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum;120-51-4;Ascabiol;Benzoic acid, phenylmethyl ester;Benzoic acid benzyl ester;Benylate;Novoscabin;Benzoic acid, benzyl ester;Ascabin;Scabitox;Scobenol;Benzyl phenylformate;Phenylmethyl benzoate;Benzylets;Colebenz;Peruscabin;Scabagen;Scabanca;Scabiozon;Vanzoate;Scabide;benzylbenzoate;Benzyl benzenecarboxylate;Benzyl alcohol benzoic ester;Venzonate;Benzylester kyseliny benzoove;BENZOIC ACID PHENYLMETHYLESTER;FEMA No. 2138;NSC 8081;UNII-N863NB338G;MFCD00003075;CHEMBL1239;Antiscabiosum;CHEBI:41237;N863NB338G;NSC-8081;NCGC00094981-03;Peruscabina;Spasmodin;Benzyl benzoate, 99+%;Benzylis benzoas;DSSTox_CID_9153;Benzylum benzoicum;DSSTox_RID_78686;DSSTox_GSID_29153;Benzoesaeurebenzylester;Caswell No. 082;Benzylbenzenecarboxylate;Venzoate;Benzyl benzoate, analytical standard;Benzyl benzoate (natural);BZM;CAS-120-51-4;SMR000471875;HSDB 208;EINECS 204-402-9;Benzylester kyseliny benzoove [Czech];EPA Pesticide Chemical Code 009501;benzylbenzoat;BRN 2049280;Benzyl benzoate [USP:JAN];Acarobenzyl;Benzevan;Bengal;Benzoic acid phenylmethyl ester;AI3-00523;1dzm;Benylate (TN);benzoic acid benzyl;Spectrum_001240;Benzoic acid-benzyl ester;Spectrum2_000532;Spectrum3_001757;Spectrum4_000773;Spectrum5_001128;ACMC-1C8AP;WLN: RVO1R;Benzyl benzoate, >=99%;EC 204-402-9;SCHEMBL3038;BENZYL BENZOATE BP98;BSPBio_003494;KBioGR_001186;KBioSS_001720;4-09-00-00307 (Beilstein Handbook Reference);MLS001066412;MLS001336003;MLS001336004;DivK1c_000204;SPECTRUM1503002;SPBio_000543;Benzyl benzoate (JP17/USP);ZINC1021;DTXSID8029153;BENZOIC ACID,BENZYL ESTER;HMS500K06;KBio1_000204;KBio2_001720;KBio2_004288;KBio2_006856
;KBio3_002714;NSC8081;NINDS_000204;HMS1921P16;HMS2092F20;HMS2269D24;Pharmakon1600-01503002;HY-B0935;Tox21_111372;Tox21_201337;Tox21_303418;ANW-17509;BDBM50134035;CCG-39578;NSC758204;s4599;SBB058609;STL183088;AKOS003495939;Benzyl benzoate, >=99%, FCC, FG;Tox21_111372_1;DB00676;MCULE-4369643785;NSC-758204;IDI1_000204;Benzyl benzoate, for synthesis, 99.0%;NCGC00094981-01;NCGC00094981-02
258889-01;AC-17033;AK308304;SBI-0051748.P002;DB-041563;B0064;FT-0622708;ST50406335;Benzyl benzoate, natural, >=99%, FCC, FG;Benzyl benzoate, ReagentPlus(R), >=99.0%;Benzyl benzoate, SAJ first grade, >=98.0%;Benzyl benzoate, tested according to Ph.Eur.;A14577;A19449;Benzyl benzoate, SAJ special grade, >=99.0%;C12537;D01138;AB00052298_07;Benzyl benzoate, Vetec(TM) reagent grade, 98%;Benzyl benzoate;Q413755;SR-01000763773;Benzoic acid-benzyl ester 5000 microg/mL in Hexane;Q-200696;SR-01000763773-2;BRD-K52072429-001-06-1;Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester
Benzyl benzoate (BnBzO) is mediation and insect repellent. It is one of the older preparation used to treat scabies which is a skin infection caused by the mite Sarcoptes scabiei since it is lethal to the mite. It is capable of killing the mite in 5 minutes. It can also be used for the treatment of lice infestation of the head and the body. Its mechanism of action is through exerting a toxic effects on the nervous system of the insects, further causing its death. It is also toxic to mite ova through an unknown mechanism. It can also be used as a repellent for chiggers, ticks, and mosquitoes as well as a dye carrier, solvent of cellulose derivatives, plasticizer, and a fixative.
Uses
Medical
Benzyl benzoate is an effective and inexpensive topical treatment for human scabies. It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs. It is also used as an excipient in some testosterone-replacement medications (like Nebido) for treating hypogonadism.
Benzyl benzoate is used as a topical acaricide, scabicide, and pediculicide in veterinary hospitals.
Non-medical
Benzyl benzoate is used as a repellent for chiggers, ticks, and mosquitoes. It is also used as a dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.
Chemistry
It is an organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e. g. tuberose) and is a component of Balsam of Peru and Tolu balsam.
Production
Benzyl benzoate is produced industrially by the reaction of sodium benzoate with benzyl alcohol in the presence of a base, or by transesterification of methyl benzoate and benzyl alcohol. It is a byproduct of benzoic acid synthesis by toluene oxidation. It can also be synthesized by the Tishchenko reaction, using benzaldehyde with sodium benzilate (generated from sodium and benzyl alcohol) as a catalyst:
The Tishchenko reaction: benzaldehyde reacts to benzyl benzoate, the catalyst is sodium benzilate.
It occurs naturally in essential oils such as ylang-ylang, rosewood, cinnamon and benzoin.
When these essential oils are not used in a product, Benzyl Benzoate can be added in its synthetic form because of its amazing scent and excellent solvent properties. Indeed, it dissolves other perfume materials, allowing them to blend more easily.
What is Benzyl Benzoate?
Benzyl benzoate is a naturally occurring molecule found in some plants and is made up of benzyl alcohol and benzoic acid. In cosmetic products, it plays a number of roles depending on the product and it can act as a fragrance, a solvent, a plasticizer, a preservative, and a fixative.
How does it work?
As a fragrance, benzyl benzoate can add a balsamic smell to a product. It can also work with other fragrances as a solvent to help them dissolve into the mixture. Benzyl benzoate also acts as a fixative in perfumed products where it slows down the escape of other fragrances and increases the life span of the fragrance.
When added to more solid products like soaps, benzyl benzoate can act as a plasticizer. A plasticizer makes a product less brittle so a soap containing it can be bent and squished more before it snaps or crumbles.
Benzyl benzoate is used to treat lice and scabies infestations. This medicine is believed to be absorbed by the lice and mites and to destroy them by acting on their nervous system.
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite Sarcoptes scabiei. It is characterized by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body.
Mechanism of action
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Absorption
No data are available on the percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however, the amount was not quantified.
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Benzyl benzoate is a benzyl compound that can be synthesized by reacting benzyl chloride with sodium benzoate in the presence of tetrabutylaramonium iodide. It is reported to be the key constituent in the essential oils isolated from leaves and stem bark of Cinnamomum zeylanicum.
Benzyl benzoate, an ester of benzyl alcohol and benzoic acid, is widely used as a fragrance fixer, fragrance ingredient and preservative to maintain the potency and stability of a variety of cosmetic formulations. It is also employed as a synthetic musk, acaricide to treat scabies and headlice.
Benzyl Alcohol is an organic alcohol found in many fruits and teas. Benzyl Alcohol has a hydroxyl group, while the related compound, Benzoic Acid has a carboxyl group. Sodium Benzoate, Calcium Benzoate and Potassium Benzoate are salts of Benzoic Acid. Benzyl Benzoate is an ester of Benzyl Alcohol and Benzoic Acid.
Benzyl Alcohol, Benzoic Acid and its salts, and Benzyl Benzoate are used in a wide variety of cosmetics and personal care products, including baby products, bath products, soaps and detergents, eye makeup, blushers, cleansing products, makeup products, as well as hair, nail and skincare products.
Why is it used in cosmetics and personal care products?
The following functions have been reported for these ingredients.
Corrosion inhibitor - Sodium Benzoate
Fragrance ingredient - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Benzyl Benzoate
pH adjuster - Benzoic Acid
Preservative - Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Calcium Benzoate, Potassium Benzoate
Solvent - Benzyl Alcohol, Benzyl Benzoate Viscosity decreasing agent - Benzyl Alcohol
Benzyl benzoate is a clear, colorless, oily liquid with a light, balsamic odor reminiscent of almond and a sharp, pungent taste. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃, it exists as clear, colorless crystals.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.
Contact allergens Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colorless liquid with a faint aromatic odor. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anesthetic effect; however, a complete cure is frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. This preparation has the additional advantage of being essentially odorless, nonstaining, and non-irritating to the skin. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide, and a plant metabolite. It is a benzyl ester and a benzoate ester. It derives from benzoic acid.
Mainly used as a non-agricultural pesticide with some veterinary applications as well as being used as a food additive and in perfumery.
Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma components of cranberry, mango, and Egyptian Jasminum sambac flowers.
It has a unique smell. It has an almond-like or balsamic scent. It is in a colorless solid or liquid form.
Boiling Point is 323.5 ° C.
Melting Point is 21 ° C.
Its solubility in water is almost negligible. It has a solubility of approximately 25 mg / L at 25 ° C.
It is insoluble in glycerin. Soluble in Ethyl Alcohol, Methyl Alcohol, Chloroform and Ethyl Ether.
Benzyl Benzoate density is 25 ° C 1.112 g / cm³.
It is a stable chemical compound in standard storage conditions.
Benzyl Benzoate Usage Areas:
• It is used in the creation of the oldest formulas used for the treatment of a skin disease called scabies. This is a skin infection. It is used to eliminate such skin infections.
• It is an ingredient used in the manufacture of drugs produced to inhibit ticks and mosquitoes.
• It is a chemical substance used as a solvent in many chemical substances.
• It is used as a solvent for cellulose substances.
• It is used as an essence in perfume production.
• It is used in the production of veterinary drugs, in chemicals produced for the treatment of skin diseases of animals.
• It is used as a sweetener in the Food Sector.
• It is used in the manufacture of pesticides for the treatment of dust settings in some textiles, carpets, mattresses and sofa upholstery and furniture.
Usage
It is one of the oldest anti-scabies drugs for both human and veterinary use. It is also used in combination with other agents against head lice and in skin protection creams.
It is also used as a solvent, as a fragrance ingredient in tobacco products, and to increase the plasticity of polymers and cellulose.
HOW BENZYL BENZOATE IS PRODUCED
Benzyl Benzoate is a naturally occurring molecule found in some plants (plant species of the genus Polyalthia) and consists of benzyl alcohol and benzoic acid. Benzyl benzoate was first studied medically in 1918.
It is a Benzoate ester obtained by formal condensation of Benzoic acid with Benzyl Alcohol. It can also be produced by the Tishchenko reaction, using benzaldehyde with sodium benzylate (produced from sodium and benzyl alcohol) as a catalyst.
BENZYL BENZOATE PHYSICAL AND CHEMICAL PROPERTIES
• Benzyl Benzoate is insoluble in water and glycerol. Soluble in ethanol, ethyl ether, acetone, benzene, methanol, chloroform.
• Benzyl Benzoate is stable under recommended storage conditions.
• Benzyl Benzoate, when heated to decompose, produces bitter and irritating fumes.
• It is in the form of a viscous liquid or solid flakes and has a weak balsamic odor.
Benzyl Benzoate has a high molecular weight, making it an extensively used fixative in the fine fragrance and perfume industry. It is used in topical pharmaceutical formulations for the treatment of lice and scabies. Additionally, Kalama Benzyl Benzoate is valued for its compatibility with candlewax, incorporating fragrance to fine candles while also promoting clean burning.
Treatment of scabies is with topical permethrin, benzyl benzoate, malathion,to its ir or oral ivermectin. The patient should apply 5% permethrin cream to the whole body, including the scalp, all folds, groin, navel, external genitalia, and skin under the nails, washing it off after 12 hours. In adults with classical scabies, treatment of the face is controversial, but in babies, the skin of the face should also be treated. A second application 7 days after the original treatment must be prescribed and all the affected members of a household require treatment at the same time to prevent cyclical reinfestations. Oral ivermectin is being increasingly used as a first-line treatment. Severe outbreaks require a second dose of ivermectin at a 2-week interval (200 µg/kg body weight). Treatment of secondary bacterial infection and antihistamines may be required. Washing clothes and linen at 60° C will kill all the young fecundated female mites (an alternative is to keep these in a plastic bag for 48-72 hours, as mites separated from the human host die within this time). It is important to explain that pruritus commonly lasts for several weeks after cure, which may be partially alleviated by non-sedating or sedating antihistamines.
Benzyl benzoate is used as an insecticide to kill scabies mites, dust mites, and ticks. It is also used as a plasticizer, a fixative in fragrances, a food additive, and a solvent. Dermatitis is the primary adverse reaction to its use as a topical solution. At high concentrations, it has been found to possess estrogenic properties and to stimulate the growth of human breast cells.
IDENTIFICATION:
Benzyl benzoate is a colorless oily liquid. It can also be in the form of leaflets. It has an almond taste and a pleasant odor. It is nearly insoluble in water. Benzyl benzoate occurs in many plants and essential oils.
USE:
Benzyl benzoate is an important commercial chemical. It is used in making plastics, as a solvent, in making other chemicals, as a food flavoring, and in perfumes. It is also used as a skin medication for humans and dogs in treating mites. Benzyl benzoate is used to control dust mites in carpets and furniture.
Industry Uses
•Dyes
•Odor agents
•Solvents (for cleaning and degreasing)
•Solvents (which become part of product formulation or mixture)
•Surface active agents
General Manufacturing Information
Industry Processing Sectors
•Air Care
•All other basic organic chemical manufacturing
•All other chemical product and preparation manufacturing
•Miscellaneous manufacturing
•Plastic material and resin manufacturing
•Soap, cleaning compound, and toilet preparation manufacturing
•Textiles, apparel, and leather manufacturing
•Fragrance
About this substance
Helpful information
This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
This substance is used in the following products: washing & cleaning products, polishes and waxes, air care products, cosmetics and personal care products, perfumes and fragrances and biocides (e.g. disinfectants, pest control products).
Another release to the environment of this substance is likely to occur from: indoor use as a processing aid and outdoor use as a processing aid.
Widespread uses by professional workers
This substance is used in the following products: polishes, washing & cleaning products, perfumes and fragrances and cosmetics and personal care products.
This substance is used in the following areas: health services and scientific research and development.
Another release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as a processing aid.
Formulation or re-packing
This substance is used in the following products: air care products, biocides (e.g. disinfectants, pest control products), leather treatment products, perfumes and fragrances, pharmaceuticals, photo-chemicals, polishes and waxes, polymers, textile treatment products and dyes, washing & cleaning products and cosmetics and personal care products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures.
Uses at industrial sites
This substance is used in the following products: washing & cleaning products, polymers, laboratory chemicals, air care products, coating products, perfumes and fragrances, polishes and waxes, textile treatment products and dyes and cosmetics and personal care products.
This substance has an industrial use resulting in the manufacture of another substance (use of intermediates).
This substance is used for the manufacture of chemicals, plastic products and textile, leather, or fur.
benzyl benzoate as a colorless, pleasant smell, taste very pungent oily liquid. The benzoic acid and benzyl alcohol ester. Insoluble in water, acetone and benzene soluble in alcohol, chloroform, ether blends, oils.
In nature, it occurs in gyömbérfélékhez belonging Kaempferia rotunda and Zingiber cassumunar the plant name.
Benzyl benzoate is a natural component of essential oils (for example jasmine, ylang-ylang, rosewood, cinnamon or benzoate). Benzyl benzoate can also be produced synthetically, but the effects do not differ. It occurs in the form of a colorless liquid or a white solid with a sweeter balsamic odor.
Benzyl benzoate is a stable substance, resistant to changes in temperature and environment, it is used as a stabilizer of fragrant compositions and the whole product. It masks the natural aroma of unscented ingredients, while also serving as a perfume thanks to its sweet balsamic scent. It also acts as a preservative and especially as a solvent (it dissolves other substances in the product). We find it in medicines to treat scabies (kills scabies mites), anti-lice preparations and insecticides. It has antimicrobial effects.
Occurrence
Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).
Uses
Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies, for example as a combination drug of benzyl benzoate/disulfiram.
It has other uses :
• a fixative in fragrances to improve the stability and other characteristics of the main ingredients
• a food additive in artificial flavours
• a plasticizer in cellulose and other polymers
• a solvent for various chemical reactions
• a treatment for sweet itch in horses
• a treatment for scaly leg mites in chickens.
Benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
As a solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.
Preparation
By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.
Production Methods
BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavours, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).
Indications
Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.
Taste threshold values
Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.
Pharmaceutical Applications
Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavours and perfumes in cosmetics and food products.
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide.
Clinical Use
Benzyl benzoate is a naturally occurring ester obtained from Peru balsam and other resins. It is also prepared synthetically from benzyl alcohol and benzoyl chloride. The ester is a clear colourless liquid with a faint aromatic odour. It is insoluble in water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when applied topically. Immediate relief from itching probably results from a local anaesthetic effect; however, a complete cure is frequently achieved with a single application of a 25% emulsion of benzyl benzoate in oleic acid, stabilized with triethanolamine. It is applied topically as a lotion over the entire dampened body, except the face.
Benzyl benzoate CAS 120-51-4 is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity has a slight fragrance. Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate is a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications to the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Benzyl Benzoate is a solvent. This means solutes such as Hormone Powders dissolve easily in it, and that is the main purpose of its use in Steroids. The Benzyl Benzoate is used to dissolve and suspend the Hormone Powder. If the correct amount of this solvent is not used the Hormone powder will 'undissolved from the solution causing the Steroids to 'Crash' (get cloudy/less effective).
Some Hormone Powder dissolves more easily than others and therefore less Benzyl Benzoate is required. The fact that varying amounts of solvent is required for the Hormone Powders is why having this page as a resource is so vital.
Benzyl Benzoate (BB) is the primary solvent, which keeps the product from is A co-solvent in steroid that serves several functions: helps dissolve the hormone, helps keep it in solution in depot (injection site), and thins the gear so it is easy to draw and inject.
Properties: In standard conditions, benzyl benzoate is a colourless or pale yellow viscous transparent liquid. In temperature conditions of 17 degrees centigrade or lower, it will be solidified into white solid. Benzyl benzoate of high purity would send out a slight fragrance.
Freezing point: ≥17°C
Boiling point: 323°C
Solubility: Benzyl benzoate is insoluble in water but soluble in organic solvents. Benzyl benzoate itself, a high-temperature solvent, is the only solvent of Musk. Benzyl benzoate has applications in the pharmacy and perfume industry just because of its characters of low volatilization and relative stability.
Applications:
Benzyl benzoate is mainly used in the area of textile auxiliary, fragrance and flavour, pharmacy, plasticizer and so on. Benzyl benzoate can be used as to lead agent, levelling agent and repair agent of textile auxiliaries. Mechanism: With the development of the textile industry, the materials are of a higher grade. The higher-grade cloth is, the more compact fabric is. So in dyeing, there are more difficulties in colouring and uniformity Due to the good plasticity performance, benzyl benzoate makes the fiber swell and undraw so that the fibre will be dyed easily. At the same time, benzyl benzoate is a good solvent to dissolve and disperse dye evenly. Since its quite good dye migration performance, benzyl benzoate could be developed as levelling agents and lead agents. There are many other materials, which have similar properties to benzyl benzoate, such as methylnaphthalene, dimethylnaphthalene, methyl salicylate, and benzene ester.
