Piroctone olamine is a preservative that is also used in anti-dandruff shampoos for anti-fungal functions.
Piroctone olamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.
Piroctone olamine has anti-fungal properties and appears as a crystalline powder in raw form that is white or slightly yellow in color.

CAS Number: 68890-66-4
EC Number: 272-574-2
Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.42

Piroctone olamine is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Piroctone olamine is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione.
Piroctone olamine is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.

Piroctone olamine is a preservative that is also used in anti-dandruff shampoos for Piroctone olamine anti-fungal functions.

Pyrithione zinc, also known as Piroctone olamine, was developed as a solution to the problem of seborrheic dermatitis, that is, dandruff, and has antibacterial, antimicrobial and antifungal properties that can help treat scalp psoriasis and acne.
The mentioned properties can destroy fungi, bacteria and microorganisms that can cause itchy complaints in the hair and scalp and cause the scalp to become flaky.

Piroctone olamine has the potential to have antifungal effects to prevent or treat fungal infections.
Piroctone olamine helps reduce inflammation in the skin.

Piroctone olamine provides antioxidant effect by protecting the skin from the harmful effects of free radicals.
Piroctone olamine shows cleansing potential to remove dirt, oil and debris.
Piroctone olamine can help eliminate bad odors.

Piroctone olamine is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
Piroctone olamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.

Piroctone olamine is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Shampoos with Piroctone olamine are very effective in curing dandruff and preventing hair loss.

Piroctone olamine has anti-fungal properties and appears as a crystalline powder in Piroctone olamine raw form that is white or slightly yellow in color.
Further, Piroctone olamine is slightly soluble in oil and water.
The chemical formula of Piroctone olamine is C14H23NO2.C2H7NO.

Piroctone olamine has a petrochemical origin.
Piroctone olamine is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.
Typically, Piroctone olamine is an alternative to the commonly used compound zinc pyrithione.

Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing Piroctone olamine are effective in treating various kinds of hair problems.

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Piroctone olamine is a pyridone derivative, which is known to have bactericidal effects on gram-positive and gram-negative bacteria and fungicidal effects and hence is a component of many cosmetic products such as anti-dandruff shampoo.

Piroctone olamine, also called Octopirox, is an antifungal of the hydroxy-pyridone family unrelated to other antiseptics used in veterinary medicine.
Members of the “pirox” family are currently used in the human field as topicals to cure onychomycosis and Malassezia-related skin disorders.

Piroctone olamine has broad in vitro activity against major dermal veterinary pathogens, including dermatophytes and yeasts as well as some Gram positive (Staphylococcus) and Gram negative (Pseudomonas) bacteria.
As opposed to azole derivatives, PO remains fully active on resting fungal cells; Piroctone olamine antiseptic activity proceeds from inhibition of the respiratory chain in yeast mitochondria.

No resistance to PO has been documented to date.
In addition, this antiseptic acts at low concentrations, has high affinity for keratin and is completely safe.
Incorporation of PO in Allermyl therefore aims at controlling microbial proliferation associated with allergic disease.

Piroctone olamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Piroctone olamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Piroctone olamine is known for many years as a successor to Ketoconazole as an excellent anti-dandruff agent.
More recently Piroctone olamine has been discovered that Piroctone olamine has a much broader protection range against all kinds of microbiological species.

Is also being used in many preservative formulations at neutral pH, which is important for sunscreen formulations.

Piroctone olamine is slightly soluble in both water and oil.
Freely soluble in 10% ethanol in water.

Soluble in solutions containing surfactants in water or in 1-10% ethanol.
The solubility of Piroctone olamine in water varies by pH value.
This is a little larger in neutral or weak basic solutions than in acid solutions.

Typical use level is only 0.05 – 0.2%.

Piroctone olamine is a hydroxamic acid that inhibits ergosterol synthesis, the main component of the cell wall of most fungi.
Piroctone olamine is used as a cream or shampoo at a 0.5–1% concentration.

Piroctone olamine alone or in combination with other agents has been demonstrated to reduce erythema, scaling, burning/stinging sensation, and pruritus in patients with FSD, with excellent cosmetic results.
Piroctone olamine is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Designed specifically to treat seborrheic dermatitis and dry scalp, Piroctone olamine offers additional benefits: Piroctone olamine is environmentally friendly, multifunctional (doubles as preserving agent), and flexible for various cosmetic formats.
Piroctone olamine is compatible with most surfactants, additives and active ingredients used in cosmetic formulations.

Piroctone olamine is an effective, practically nontoxic antidandruff active ingredient.
Piroctone olamine is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine is a highly effective antidandruff agent and an anti-acne active agent.
Piroctone olamine is antimicrobial, soluble in surfactant systems.
Piroctone olamine is used shampoos, shower products, liquid soaps, hair conditioners, hair styling products, antiperspirant & deodorants.

Piroctone olamine, despite the recent upsurge in usage, has historically not been a hugely popular ingredient.
So very few independent clinical studies have been performed.
Piroctone olamine main advantage is that it’s well tolerated, and so can be used frequently to control mild dandruff, but this hasn’t been properly evaluated.

Piroctone olamine is one of the more recent active ingredients found in dandruff shampoos.
Designed to treat seborrheic dermatitis and dry scalp Piroctone olamine is one of the most innovative areas of dandruff treatment on the market today.

Dandruff and seborrheic dermatitis can cause hair loss and thinning hair.
Piroctone olamine is assumed that dandruff and seborrheic dermatitis (dandruff is a form of seborrheic dermatitis) are caused by a yeast (single cell fungus) on the skin, the Malassezia globose.
This is a fungus that occurs only on the scalp.

Often times, the problem will not go away on Piroctone olamine own and requires continues treatment.
A well-known agent for this is shampoo with Ketoconazole in high concentration.
Multiple studies about the effectiveness of Piroctone olamine have shown that Piroctone olamine stimulates hair growth and helps against hereditary hair loss.

Ketoconazole is most well-known, but Piroctone olamine is not the only proven anti-dandruff ingredient in shampoos which stimulates hair growth.
Piroctone olamine has a similar effect as Ketoconazole.

Piroctone olamine is also listed under the brand name 'Octopirox'.
In a study with 150 men who suffer from hereditary hair loss and dandruff, Ketoconazole and Piroctone olamine were compared.

Excessive secretion of sebum, dandruff and seborrheic dermatitis are often linked with hair loss and hereditary hair loss.
The 150 men received a shampoo with 1% Ketoconazole or 1% Piroctone olamine.
They had to use this shampoo 2 to 3 times per week for a duration of six months.

All treatments showed a reduction in itching and dandruff after 2 to 6 weeks.

If we take a look at the effect of the treatments on various hair growth parameters, we see the following figures (in percentages):
The severity of hair loss decreases (Ketoconazole: -17.3%, Piroctone olamine: -16.5%)

The percentage of hairs in the growth phase increases (Ketoconazole 4.9%, Piroctone olamine: 7.9%)
The effect on the hair diameter is increased by 5.4% with Ketoconazole and by 7.7% with Piroctone olamine.

Thus, the study shows that Piroctone olamine scores better in a number of areas in comparison to Ketoconazole.

Compared to Ketoconazole, Piroctone olamine ensures an increase in the number of hairs in the growth phase (anagen phase) by more than 10% in 33% of people.
Piroctone olamine gives 88% of the people thicker hair, despite hereditary hair loss, whereby this is 78% with Ketoconazole.
If we take a look at how many people experience a significant increase (more than 10%) of the hair diameter, this is 28% with Ketoconazole and as much as 34% with Piroctone olamine (10% larger diameter means that the hair became 20% heavier).

The above results show that both Ketoconazole and Piroctone olamine have a positive effect on multiple aspects of hair growth.
They have a similar effect on itch and dandruff.
Piroctone olamine generally scores better when Piroctone olamine comes to hair growth.

Piroctone olamine is a preservative also used for Piroctone olamine antifungal functions in anti-dandruff shampoos.
Piroctone olamine is forbidden in organic.

Restriction in Europe:
Maximum concentration in ready-to-use preparation

Maximum content of secondary amine: 0.5%

Other restrictions:
Do not use with nitrosating systems
Minimum purity: 99%
Maximum content of secondary amine: 0.5% (applies to raw materials)
Maximum nitrosamine content: 50 micrograms / kg
Keep in containers without nitrite

If used as a conservator:

The maximum concentration allowed in ready-to-use cosmetic preparations is:
1.0% in Piroctone olamines to be rinsed
0,5% in other products

Applications of Piroctone olamine:
Piroctone olamine is quite beneficial in maintaining cosmetic and personal care products.
Piroctone olamine can commonly be found in products like shampoos, cleansers, and hair masks.

Skin care:
Piroctone olamine can be used to eliminate the bad odor from the surface of the skin.
Piroctone olamine is a great preservative that helps in keeping skin care products free from bacterial growth.

Hair care:
Piroctone olamine is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone olamine is also good for preventing hair loss and split ends.

Cosmetic products:
In cosmetic products, Piroctone olamine makes use of Piroctone olamine antifungal properties to keep Piroctone olamines free from unwanted bacterial growth for a longer time.
The addition of Piroctone olamine improves the quality of Piroctone olamines and makes them last longer.

Uses of Piroctone olamine:
Piroctone olamine is a broad-spectrum microbiocide/microbiostat, may be used in formulating antidandruff shampoo, hair keep and hair care, soap, etc.

Piroctone olamine is used in shampoo, hair care, bath liquid, cosmetics, skin care products and washing products.
Piroctone olamine has a unique effect in relieving skin itching, with excellent anti-itch effect, can effectively kill fungi on the skin, and has a special effect in eliminating body odor.
Piroctone olamine is a safe, non-toxic, non-stimulating, ideally effective fungicide.

Piroctone olamine anti-dandruff and anti-itch effect is superior to similar products.
Excellent solubility and compound performance, no precipitation or stratification when mixed with cosmetic raw materials.
Unique anti-dandruff mechanism, very low irritation, no hair loss, no hair breakage, safety is better than similar anti-dandruff anti-itch products.

Suggested use:
One in every three persons suffers from a problem related to their hair.
Whether Piroctone olamine is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.

And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.

The most effective are not usually the ones which are famous (as anything can become famous if Piroctone olamine is marketed and advertised well), they are the ones that have the appropriate ingredients.
Piroctone olamine is the answer to that question.

Rate of Application:
Antidandruff hair keep: 0.1-0.8% active ingredient.
Antidandruff fixing agent: 0.05-0.2% active ingredient.
Antidandruff hair emulsion: 0.1-0.3% active ingredient.
Antidandruff hair supporting: 0.05-0.1% active ingredient.
Preservative: 0.2-0.5% active ingredient
Smell-eliminating agent: 0.2-0.5% active ingredient
Smell-eliminating scented soap: 0.2-0.5% active ingredient.

Consumer Uses:
Piroctone olamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Other release to the environment of Piroctone olamine is likely to occur from: indoor use as processing aid.

Widespread uses by professional workers:
Piroctone olamine is used in the following products: cosmetics and personal care products.
Piroctone olamine is used for the manufacture of: chemicals.
Other release to the environment of Piroctone olamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Uses at industrial sites:
Piroctone olamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Piroctone olamine is used for the manufacture of: chemicals.
Release to the environment of Piroctone olamine can occur from industrial use: in processing aids at industrial sites and in the production of articles.

Benefits of Piroctone olamine:
Piroctone olamine has been specially developed to solve dandruff problems.
Piroctone olamine prevents the scalp from flaking.

Piroctone olamine contributes to the purification of hair roots from bacteria and fungi.
Piroctone olamine is effective in eliminating the factors that cause itching at the roots of the hair.
Piroctone olamine helps purify and cleanse the hair and scalp.

Shampoos, which have Piroctone olamine as one of their ingredients, are known to eliminate dandruff.
However, before we learn how they cure dandruff, we must know what causes dandruff in the first place.

Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations.
Often all these together cause dandruff.

Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.
Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.

This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.
The reason why shampoos with Piroctone olamine can reduce and eliminate dandruff is that Piroctone olamine is known to kill the fungus or the fungal infections that irritate the scalp.

Moreover, Piroctone olamine is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone olamine is considered a great ingredient in shampoos.

Cures Dandruff:
Malassezia Globosa is not a friendly fungus found in your scalp.
Piroctone olamine is the main reason behind scalp issues like dandruff and seborrheic dermatitis.

Your scalp becomes irritated and starts shedding tiny flakes.
In severe cases, you will notice inflammation, redness, and extremely itchy patches.
If you want to prevent your scalp from worsening, it’s essential to control the situation promptly.

Piroctone olamine has antifungal properties, which will help you control the spread of Malassezia globosa.
Use an anti-dandruff shampoo containing Piroctone olamine to fight dandruff.

Prevents Hair Loss:
Regardless of your gender and age, you may face hair fall, mostly caused due to dirt, dust, pollution, dandruff, excessive use of hair styling tools, etc.
Dandruff makes your scalp itchy, which leads to constant scratching, redness, and hair follicle damage.

Even though hair fall due to dandruff is not a significant concern but in people with androgenic alopecia (a condition that leads to baldness), Piroctone olamine is a proven cure for reducing hair fall.
As Piroctone olamine effectively works on dandruff and fungal infections, naturally, your hair loss decreases over time.

Boosts Hair Growth:
Piroctone olamine encourages hair growth in many ways.
Piroctone olamine reduces hair fall and increases the hair diameter.
Piroctone olamine is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone olamine provides better results for dandruff and fungal infections.

Ketoconazole + Piroctone olamine is a combination of two antifungal medicines:
Ketoconazole and Piroctone olamine which treat dandruff.

Ketoconazole kills fungi by destroying the fungal cell membrane.
Piroctone olamine works by penetrating the cell membrane of the fungi to interfere with their energy metabolism and oxygen uptake.
This kills the fungi and clears up the infection.

Functions of Piroctone olamine:

Preservative:
Inhibits the development of microorganisms in cosmetic products.

Anti dandruff:
Helps fight against dandruff.
Piroctone olamine is an active, dandruff-fighting ingredient used in some of our shampoos.

Characteristics of Piroctone olamine:
Piroctone olamine is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp.
Piroctone olamine also reduced sebum production.

Appearance of Piroctone olamine:
Piroctone olamine has a white crystalline powder structure.

Resolution
Piroctone olamine has low solubility in water.
Piroctone olamine dissolves better in some organic compounds.

Solubility of Piroctone olamine:
The solubility of Piroctone olamine is greatly dependent on the pH.
Generally speaking, Piroctone olamine solubility in aqueous formulations is greater in the neutral and weakly alkaline ranges than in the acid range (formation of free acid).
Piroctone olamine does however have adequate solubility in the usual pH range (pH5 - 8) in commercial surfactant solutions and alcohol-water mixtures.

Extraction method of Piroctone olamine:
Piroctone olamine is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone olamine is a compound, which is often used to cure fungal infections.
Piroctone olamine is a hydroxamic acid derivative Piroctone.

Origin of Piroctone olamine:
Piroctone olamine is of petrochemical origin and helps treat dandruff.
There is no natural alternative that comes close to being as effective as this.

History of Piroctone olamine:
Piroctone olamine has been used for around 40 years, first developed by Schwarzkopf-Henkel for use in anti-dandruff shampoo in the late 1970s.
All the initial clinical and safety studies were conducted by Hoechst AG, but this changed in the mid-1990s when other cosmetics companies began using the ingredient.

Piroctone olamine was first submitted for approval to the European Union and United States FDA in the 1980s.
The ingredient was first approved for addition to the United States Pharmacopeia (USP) in 2008, after the FDA sought additional safety and effectiveness data in 2004.

Handling and storage of Piroctone olamine:

Advice on safe handling:
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.

Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.

Storage stability:

Recommended storage temperature: 2 - 8 °C

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and reactivity of Piroctone olamine:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

Incompatible materials:
Strong acids and oxidizing agents, Strong oxidizing agents

Health Effect of Piroctone olamine:
If used as a preservative, Piroctone olamine should be used at a maximum rate of 1.0% in rinsed products and at a maximum rate of 0.5% in other products.
Piroctone olamine should not be used together with nitrosamine-forming agents.

Nitrosamines are carcinogenic substances.
The impurity rate should be 99%.

The maximum amount of secondary amine should be 0.5%.
The maximum amount of nitrosamine cannot exceed 50 micrograms/kg. The raw material should be stored in nitrite-free packaging.

Piroctone olamine is a synthetic component.
They are raw materials produced using various processes under laboratory conditions.

These are raw materials obtained without using animal sources (propolis, honey, beeswax, lanolin, collagen, snail extract, milk, etc.).
Piroctone olamine is a criterion that should be taken into consideration for those who want to use vegan products.

Studies have concluded that different effects can be seen on each skin type.
For this reason, the allergy/irritation effect may vary from person to person.
However, Piroctone olamine causes stinging, tingling, itching, redness and irritation, especially in people with sensitive skin types.

Precaution of Piroctone olamine:
However, just like excess of anything is bad, too much of Piroctone olamine can be bad for the scalp too.
This is precisely why shampoos with Piroctone olamine have a very minor amount of Piroctone olamine so that its side effects do not affect the scalp in any way.

Piroctone olamine should be kept in mind that shampoos with Piroctone olamine should not be used more than twice a week, unlike other daily use shampoos that don’t have this ingredient.
One of the biggest side effects of Piroctone olamine is that it can cause irritation and itchiness on the head.

First aid measures of Piroctone olamine:

General advice:
Consult a physician.

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.

In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures of Piroctone olamine:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from Piroctone olamine:
Carbon oxides
Nitrogen oxides (NOx)

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

Further information:
No data available

Accidental release measures of Piroctone olamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid dust formation.

Avoid breathing vapors, mist orgas.
Ensure adequate ventilation.

Evacuate personnel to safe areas.
Avoid breathing dust.

Environmental precautions of Piroctone olamine:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Identifiers of Piroctone olamine:
CAS Number: 68890-66-4
ChemSpider: 45574
ECHA InfoCard: 100.065.957
MeSH: Piroctone+olamine
PubChem CID: 50258
UNII: A4V5C6R9FB
CompTox Dashboard (EPA): DTXSID4046735
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYAP
SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

CAS NO: 68890-66-4
EC NO: 272-574-2

Synonym(s): 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
CAS Number: 68890-66-4
Molecular Weight: 298.42
EC Number: 272-574-2
MDL number: MFCD01690792
PubChem Substance ID: 329757760
NACRES: NA.24

Product Number: P2178
Purity / Analysis Method: >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight: C14H23NO2·C2H7NO = 298.43
Physical State (20 deg.C): Solid
Storage Temperature: 0-10°C
Condition to Avoid: Heat Sensitive
CAS No: 68890-66-4
Related CAS No: 50650-76-5
Reaxys Registry Number: 7503297
PubChem Substance ID: 253662076
Merck Index (14): 7502
MDL Number: MFCD01690792

Properties of Piroctone olamine:
Chemical formula: C16H30N2O3
Molar mass: 298.421

Molecular weight: 298.43
Formula: C14H23NO2·C2H7NO
Purity: >97.0%(T)(HPLC)
Color/Form: White to Almost white powder to crystal
MDL: MFCD01690792
Melting point: 136 °C
Flash point: 136 °C
HS code: 2933790090

grade: analytical standard
Quality Level: 100
Assay: ≥99.0% (HPLC)
shelf life: limited shelf life, expiry date on the label

technique(s)
HPLC: suitable
gas chromatography (GC): suitable

application(s):
agriculture
environmental

format: neat
storage temp.: 2-8°C
SMILES string: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C
InChI: 1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChI key: BTSZTGGZJQFALU-UHFFFAOYSA-N

Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 298.22564282 g/mol
Monoisotopic Mass: 298.22564282 g/mol
Topological Polar Surface Area: 86.8Ų
Heavy Atom Count: 21
Complexity: 371
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Specification of Piroctone olamine:
Appearance: White or slightly yellow crystalline powder
Odor: Characteristic

Solubility:
Water (0.10g +10ml):non-soluble
Methanol (1.00g + 10ml): soluble

Purity(HPLC) %: ≥99.0
PH value(1% aqueous suspension,20℃): 8.5-10.0
Melting Point ℃: 130-135
Drying loss %: ≤0.3
Ash(SO4) %: ≤0.2
Particle size distribution: D(0.5): 30-50um Provide a profile representative of the raw material
E1% (1cm) at 317 nm expressed an dried substance: 214-236
Ethanolamine %: 20.0-21.0
Nitrosamine content PPB: ≤50
Heavy metals(Pb,As,Cd,Co,Cr,Hg,Ni,Sb) PPM: ≤10
Hexane(GC) PPM: ≤300
Ethyl acetate(GC) PPM: ≤5000

Names of Piroctone olamine:

Regulatory process names:
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon, monoethanolamine salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1)
Kopirox
Octopirox
Piroctone ethanolamine salt
Piroctone olamine

IUPAC names:
(RS)-1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2(1H)-PYRIDINONE ETHANOLAMINE (1:1)
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpently)pyridin-2-(1H)-one compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one,compound with 2-aminoethanol (1:1)
1-hydroxy-4methyl-6-(2,4,4-trimethylphenyl)pyridine-2(1H)-one, compound with 2-aminoethanol(1:1)
2-aminoethanol; 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-amminoetanolo; 1-idrossi-4-metil-6-(2,4,4-trimethylpentyl) pyridin-2-one
Octopirox
Piroctone Olamine
Piroctone Olamine
Piroctone olamine

Trade names:
Picroctone Olamine
Piroctone olamine

Other identifier:
68890-66-4

Synonyms of Piroctone olamine:
PIROCTONE OLAMINE
68890-66-4
Octopirox
Piroctone ethanolamine
Kopirox
Piroctoneolamine
Octopyrox
Piroctone ethanolamine salt
Piroctone olamine [USAN]
C14H23NO2.C2H7NO
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
EINECS 272-574-2
UNII-A4V5C6R9FB
A4V5C6R9FB
NSC-759894
PIROCTONE ETHANOLAMINE SALT (1:1)
Piroctone olamine (USAN)
EC 272-574-2
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)
Octopirox (TN)
SCHEMBL2843
CHEMBL2107154
PIROCTONE OLAMINE [INCI]
PIROCTONE OLAMINE [MART.]
PIROCTONE OLAMINE [USP-RS]
AMY40819
BCP29912
HY-B1345
MFCD01690792
s5213
Piroctone olamine, analytical standard
AKOS025149526
CCG-267454
CS-7659
NSC 759894
PIROCTONE ETHANOLAMINE [WHO-DD]
AS-15254
C14-H23-N-O2.C2-H7-N-O
LS-133057
FT-0653357
P2178
D05505
Piroctone ethanolamine salt; Octopirox; Kopirox
PIROCTONE ETHANOLAMINE SALT (1:1) [MI]
A836281
Q412572
W-104652
4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine
Piroctone olamine, United States Pharmacopeia (USP) Reference Standard
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt
1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-
1- hydroxy- 4- methyl- 6- (2, 4, 4- trimethylpentyl)pyridin- 2(1H)- one, compound with 2- aminoethanol (1:1)
Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon --2-aminoethanol (1:1) [German] [ACD/IUPAC Name]
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1) [ACD/IUPAC Name]
1-Hydroxy-4-méthyl-6-(2,4,4-triméthylpentyl)-2(1H)-pyridinone - 2-aminoéthanol (1:1) [French] [ACD/IUPAC Name]
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-Aminoethanol Salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1) [ACD/Index Name]
272-574-2 [EINECS]
68890-66-4 [RN]
A4V5C6R9FB
MFCD01690792
octopirox [Trade name]
Piroctone ethanolamine
Piroctone ethanolamine salt
Piroctone olamine [Wiki]
UNII:A4V5C6R9FB
[68890-66-4] [RN]
1-Aminoethane
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanol ammonium salt
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
2-aminoethanol and 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-hydroxyethylammonium; 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone
Octopirox| Piroctone ethanolamine
Piroctone
Piroctone olamin
PIROCTONE OLEAMINE
QA-6124

Piroctone Olamine is an amine salt.
Piroctone Olamine has a white crystalline powder structure.
Piroctone Olamine has low solubility in water.


CAS Number: 68890-66-4
EC Number: 272-574-2
Chem/IUPAC Name: 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
Molecular Formula: C16H30N2O3



SYNONYMS:
Piroctone Olamine, 68890-66-4, Octopirox, Kopirox, Piroctone Ethanolamine, Octopyrox, Piroctoneolamine, Piroctone Ethanolamine Salt, Piroctone Olamine [USAN], UNII-A4V5C6R9FB, EINECS 272-574-2, A4V5C6R9FB, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, NSC-759894, Piroctone Ethanolamine Salt (1:1), EC 272-574-2, NSC 759894, Piroctone Olamine (USAN), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, PIROCTONE OLAMINE (MART.), PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE (USP-RS), PIROCTONE OLAMINE [USP-RS], 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, DTXCID2026735, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Allermyl, Keratolux, Octopirox (TN), SCHEMBL2843, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), CHEMBL2107154, BTSZTGGZJQFALU-UHFFFAOYSA-N, AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone Olamine, Analytical Standard, AKOS025149526, CCG-267454, CS-7659, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, P2178, D05505, Piroctone Ethanolamine Salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone Olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt, EcoGard, POOctopirox, Piroctone Olamine, Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, Octopirox, Octopyrox, Piroctone Ethanolamine Salt, Piroctone Olamine



Piroctone Olamine is an anti-dandruff product that works very effectively as antimicrobial, anti-odor and anti-acne, with a usage rate of maximum 1% for rinsed products and maximum 0.5% for non-rinsed products.
Effectively eliminates unpleasant odors in both humans and pets.


Piroctone Olamine reduces sebum outflow on the skin surface and is suitable for anti-acne application.
Piroctone Olamine is a clinically approved, effective, safe to use and non-irritating alternative to Zinc Pyrithione and a more successful product than Zinc Pyrithione.


Piroctone olamine has a special effect against Pityrosporum Ovale, which is responsible for the production of dandruff.
Piroctone Olamine has a white crystalline powder structure.
Piroctone Olamine has low solubility in water.


Piroctone Olamine dissolves better in some organic compounds.
Piroctone Olamine has the potential to have antifungal effects to prevent or treat fungal infections.
Piroctone Olamine helps reduce inflammation in the skin.


Piroctone Olamine provides antioxidant effect by protecting the skin from the harmful effects of free radicals.
Piroctone Olamine shows cleansing potential to remove dirt, oil and debris.
Piroctone Olamine can help eliminate bad odors.


Piroctone olamine (INN; also known as piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone was first synthesized in 1979 by Schwarzkopf-Henkel (Germany).
Piroctone Olamine is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis


Aako PO is better known as Piroctone Olamine.
Piroctone Olamine is known for many years as a successor to Ketoconazole as an excellent anti-dandruff agent.
More recently it has been discovered that Piroctone Olamine has a much broader protection range against all kinds of microbiological species.


Piroctone Olamine is slightly soluble in both water and oil.
Freely soluble in 10% ethanol in water.
Piroctone Olamine is soluble in solutions containing surfactants in water or in 1-10% ethanol.


The solubility of Piroctone Olamine in water varies by pH value.
This is a little larger in neutral or weak basic solutions than in acid solutions.
Typical use level of Piroctone Olamine is only 0.05 – 0.2%.


Piroctone Olamine is also known under the names PO.
Piroctone Olamine, (1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone,2-aminoethanol salt(1:1)) SpecKare PO is a special and widely used anti-dandruff which may be used in all kinds of hair products.


The anti-dandruff product containing Piroctone Olamine destroys the fungus infection that is responsible for the dandruff and works against the formation of new dandruff.
Piroctone Olamine makes the scalp stay clean and itch free.


Piroctone olamine is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Piroctone Olamine is a white to off-white crystalline powder with a very faint odor.


Piroctone Olamine is insoluble in water, mineral oil, and isopropylene; and soluble in ethanol and propylene glycol.
Piroctone Olamine is a remarkably effective anti-dandruff agent almost nontoxic ingredient for haircare products and clear shampoo.
Piroctone Olamine is an anti-dandruff product that works very effectively as an antimicrobial, anti-odor and anti-acne, with a maximum usage rate of 1% in rinsed products and 0.5% in non-rinsed products.


Piroctone Olamine exhibits low toxicity, low irritation, and excellent efficacy in hair care applications.
In addition, Piroctone Olamine has good pH and thermal stability, solubility in surfactant systems, and good compatibility with other ingredients.
Piroctone Olamine is the only anti-dandruff agent approved for both rinse-off & leave-on products.


In comparison with other popular anti-dandruff agents, Piroctone Olamine is the best cost-performance option.
Piroctone Olamine has a petrochemical origin.
Piroctone Olamine is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.


Typically, piroctone olamine is an alternative to the commonly used compound zinc pyrithione.
Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing piroctone olamine are effective in treating various kinds of hair problems.


Piroctone Olamine is soluble in ethanol, slightly soluble in water, which is safe, non-toxic and non-irritating.
Piroctone Olamine can destroy the fungus infection that is responsible for the dandruff and work against the formation of new dandruff, make the scalp stays clean, itch free and prevent the formation of new dandruff.


Piroctone Olamine also can eliminate unpleasent odor effectively, decrease the sebum output at the skin surface.
Piroctone Olamine has wide-spectrum of anti-bacteria and anti-fungi properties, and has an obvious action of increasing the shampoo viscosity of the salt thickening system.



USES and APPLICATIONS of PIROCTONE OLAMINE:
Enhancing Skincare: The suggestion is make to consider exploring products that contain Piroctone Olamine as an ingredient, possibly in combination with other essential oils and skincare products.
Piroctone Olamine is a versatile ingredient that uses in the formulation of products designed to address dandruff issues, control bacterial growth, and manage body odor.


Piroctone Olamine commonly finds in shampoos, hair tonics, and similar products intended for scalp and hair care.
Additionally, its thickening and preservation properties make Piroctone Olamine valuable in various cosmetic formulations.
As with any cosmetic or skincare ingredient, it’s essential to follow the manufacturer’s instructions and use products containing Piroctone Olamine as directed for best results and safety.


Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.


Piroctone Olamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.
The anti-dandruff product containing piroctone olamine eliminates the fungal infection responsible for dandruff and works against the formation of new dandruff, keeps the scalp clean, does not itch and prevents the formation of new dandruff.


Piroctone Olamine is used Shampoo, Deodorant (Pet care), Soap, Aftershave balm, anti irritation cream, anti acne cream, and hair mask.
Piroctone Olamine is used in volumizing shampoo formulas that increase hair thickness.
The usage rate of Piroctone Olamine is generally between 0.5% and 2% in hair products and 0.1% and 1% in skin care products.


Piroctone Olamine is also being used in many preservative formulations at neutral pH, which is important for sunscreen formulations.
Combined with AakoSun EHG or other preservative boosters Piroctone Olamine gives strong preservation of your cosmetic, deodorant or sunscreen formulation.
Piroctone Olamine is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione which was banned in the EU in 2021 because of concerns for environmental toxicity.


Piroctone Olamine is often used in anti-dandruff shampoo.
Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.


Piroctone Olamine is used anti-dandruff & anti-itching agent, eliminate dandruff at source by being bactericidal and antioxidant, effectively inhibit Malassezia, replace Zinc pyrithione (ZPT is a prohibition of use in Europe because it causes cancer), widely be used for shampoo, body wash ,hair-conditioner,mist spray,hair removal cream,antiperspirant deodorant etc; Broad-spectrum antibacterial properties , also can be used as a preservative in cosmetics ; Oil-control & anti-acne , used for face serum.

Products and services : Anti-microbial agents, Antioxidants.
Piroctone Olamine is used body make-up, Cleansing, shampoos, Hand / foot / nail care, Body care, Hand wash / sanitizers, Bath and shower, scrubs, Cleansers, soaps.


Piroctone olamine is a preservative also used for its antifungal functions in anti-dandruff shampoos.
Piroctone Olamine effectively eliminates unpleasant odors in both humans and pets.
Piroctone Olamine is used in shampoo formulas that increase hair thickness and add volume.


Piroctone Olamine reduces the sebum output on the skin surface and is suitable for anti-acne application.
Piroctone Olamine is a clinically approved effective, safe to use and non-irritating alternative to Zinc Pyrithione, and Zinc Pyrithione is a better successful product.


Piroctone olamine has a special effect against Pityrosporum Ovale, which is responsible for the production of dandruff.
The anti-dandruff product containing piroctone olamine destroys the fungal infection responsible for dandruff and works against the formation of new dandruff, keeps the scalp clean, does not itch and prevents the formation of new dandruff.


Thanks to its antiseptic properties, Piroctone Olamine can be used as an antimicrobial agent, deodorant, or even a preservative.
Thus, Piroctone Olamine is suitable for anti-acne preparations, antiperspirants, and various cosmetic products as a preservative with low toxicity.
Piroctone olamine acts as an anti-dandruff agent.


Piroctone Olamine is also used as a preservative and thickening agent for elimination of body offensive smell.
Piroctone Olamine is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp.


Piroctone Olamine also reduced sebum production. Piroctone Olamine is used in shampoos (non-coloring), tonics, dressings and other hair grooming aids.
Therefore Piroctone Olamine can be used in anti-dandruff shampoo, hair keep and hair care, soap and other products.
Piroctone Olamine is another active ingredient that is commonly used in hair care products to treat dandruff and other scalp conditions.


Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma
Like zinc pyrithione, Piroctone Olamine works by controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues.
Piroctone Olamine is an antifungal ingredient that is commonly used in hair care products to treat dandruff and other scalp conditions.


Piroctone Olamine is also known by its trade name, Octopirox.
Piroctone Olamine works by controlling the growth of Malassezia, a type of yeast that is commonly found on the scalp and can contribute to dandruff and other scalp issues.


Piroctone Olamine does this by disrupting the cell membrane of the yeast, which prevents it from multiplying and spreading.
In addition to its antifungal properties, Piroctone Olamine also has moisturizing properties that can help to soothe and hydrate the scalp, preventing dryness and flakiness.


Piroctone Olamine is generally considered safe for use in hair care products, and it is suitable for those with sensitive skin.
Piroctone Olamine is also safe for use on coloured hair and will not cause fading or strip color.
Overall, Piroctone Olamine is an effective ingredient for controlling dandruff and promoting a healthy scalp.



PIROCTONE OLAMINE SHAMPOO:
We use piroctone olamine (PO) in our shampoos because it’s an effective active ingredient that targets the symptoms of dandruff and its root cause – Malassezia globosa.

Unlike some other dandruff actives you may have heard of, piroctone olamine has a special chemical structure that is easy to dissolve in our shampoo formula, which means that we can design the product to give your hair extra benefits like smoothness and softness.

All this means that not only do you get the anti-dandruff properties you’d expect from Head & Shoulders shampoo, but hair that’s great looking and delightfully soft too.



SUGGESTED USE OF PIROCTONE OLAMINE:
One in every three persons suffers from a problem related to their hair.
Whether Piroctone Olamine is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.

And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.

The most effective ones are not usually the ones which are famous (as anything can become famous if it is marketed and advertised well), they are the ones that have the appropriate ingredients.
Piroctone Olamine is the answer to that question.



WHAT IS PIROCTONE OLAMINE USED FOR?
Piroctone Olamine is quite beneficial in maintaining cosmetic and personal care products.
Piroctone Olamine can commonly be found in products like shampoos, cleansers, and hair masks.


*Skin care:
Piroctone Olamine can be used to eliminate the bad odor from the surface of the skin.
Piroctone Olamine is a great preservative that helps in keeping skin care products free from bacterial growth


*Hair care:
Piroctone Olamine is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone Olamine is also good for preventing hair loss and split ends


*Cosmetic products:
In cosmetic products, Piroctone Olamine makes use of its antifungal properties to keep the products free from unwanted bacterial growth for a longer time.
The addition of Piroctone Olamine improves the quality of the products and makes them last longer



ORIGIN OF PIROCTONE OLAMINE:
Piroctone Olamine is basically an ethanolamine salt that is derived from Piroctone - which is a derivative of hydroxamic acid.
Piroctone Olamine appears as a crystalline white powder with a faint distinctive odor.



WHAT DOES PIROCTONE OLAMINE DO IN A FORMULATION?
*Antimicrobial
*Preservative



SAFETY PROFILE OF PIROCTONE OLAMINE:
Piroctone Olamine is safe for use when added under the recommended percentage usage - 0.1% for rinse-off products and 0.5% for leave-on products.
Piroctone Olamine suits all skin and hair types, however, a patch test should be performed before full application.
Lastly, Piroctone Olamine is not used in organic products because it is a chemical preservative.



ALTERNATIVES OF PIROCTONE OLAMINE:
*ZINC PYRITHIONE



HOW DOES PIROCTONE OLAMINE WORK?
Piroctone olamine has anti-fungal properties that make it ideal for controlling the root cause of dandruff, a commonly occurring fungus called Malassezia globosa.

The fungus occurs naturally on everyone’s scalp, but some people are sensitive to the chemicals it produces.
The skin becomes irritated, and the body reacts by rapidly shedding skin to try and get rid of the irritant, causing flaking.
Stopping this process is the key to stopping dandruff.



BENEFITS OF PIROCTONE OLAMINE FOR HAIR:
Piroctone Olamine is a popular ingredient in hair care products that are designed to treat dandruff and other scalp conditions.
Here are some of the benefits of using Piroctone Olamine for your hair:


*Controls dandruff:
Piroctone Olamine is effective at controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues.
By controlling the growth of this yeast, Piroctone Olamine can help to reduce or eliminate dandruff.


*Soothes the scalp:
Piroctone Olamine has moisturizing properties that can help to soothe and hydrate the scalp.
This can help to prevent dryness, flakiness, and itching, which are common symptoms of dandruff and other scalp conditions.


*Safe for coloured hair:
Piroctone Olamine is safe for use on coloured hair and will not cause fading or strip color.


*Prevents fungal growth:
Piroctone Olamine not only controls the growth of Malassezia, but it also prevents the growth of other fungi that can cause scalp problems.


*Long-lasting effect:
Piroctone Olamine has been shown to have a longer-lasting effect than some other dandruff-fighting ingredients, meaning you may be able to go longer between washes.


*Gentle on the scalp:
Piroctone Olamine is gentle on the scalp, making it suitable for those with sensitive skin.

Overall, Piroctone Olamine can be an effective ingredient for controlling dandruff and promoting a healthy scalp.
If you have persistent scalp issues that do not respond to over-the-counter treatments, it's a good idea to see a dermatologist for a proper diagnosis and treatment plan.



FUNCTIONS OF PIROCTONE OLAMINE IN COSMETIC PRODUCTS:
*ANTI-SEBORRHEIC
Piroctone Olamine prevents seborrhea and / or seborrheic dermatitis or relieves their symptoms; and / or acts against dandruff

*PRESERVATIVE
Piroctone Olamine protects cosmetic products from microbial spoilage



EXTRACTION METHOD OF PIROCTONE OLAMINE:
Piroctone Olamine is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone Olamine is a compound, which is often used to cure fungal infections.
This salt is a hydroxamic acid derivative Piroctone.



BENEFITS OF PIROCTONE OLAMINE:
Shampoos, which have Piroctone Olamine as one of their ingredients, are known to eliminate dandruff.
However, before we learn how they cure dandruff, we must know what causes dandruff in the first place.

Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations.
Often all these together cause dandruff.

Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.

Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.
This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.

The reason why shampoos with Piroctone Olamine can reduce and eliminate dandruff is that Piroctone Olamine is known to kill the fungus or the fungal infections that irritate the scalp.

Moreover, Piroctone Olamine is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone Olamine is considered a great ingredient in shampoos.



HOW DOES PIROCTONE OLAMINE WORK?
Piroctone olamine, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions.

Piroctone Olamine works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism.

Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death.
Piroctone Olamine also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.

Piroctone olamine has a broad-spectrum activity against many microorganisms, making it a valuable ingredient in cosmetic and personal care products.
Piroctone Olamine is also considered safe for use, with low toxicity and irritation potential, making it suitable for use on sensitive skin.



BENEFITS OF PIROCTONE OLAMINE:
*Very high purity Piroctone Olamine
*Being used often because of it’s special functions such as thickening preservation and elimination of body offensive odor.



FUNCTIONS OF PIROCTONE OLAMINE:
*Anti-dandruff
*Antiseptic
*Preservative
*Anti-Seborrheic



ADVANTAGES AND BENEFITS OF PIROCTONE OLAMINE:
The use of Piroctone Olamine offers a series of advantages and benefits for personal care needs.
Piroctone Olamine has a powerful anti-inflammatory, antibacterial and antimicrobial action.

Furthermore:
Piroctone Olamine prevents hair loss
Piroctone Olamine improves scalp health
Piroctone Olamine is easily soluble in alcohol
Piroctone Olamine is soluble in aqueous solutions of surfactants



BENEFITS CLAIMS OF PIROCTONE OLAMINE:
*Anti-Dandruff,
*Anti-Fungal,
*Anti-Itching,
*Compatibility,
*Scalp Protection Effect,
*Versatility,
*Viscosity Boosting



PIROCTONE OLAMINE POWDER:
Piroctone olamine powder is ethanolamine salt of hydroxamic piroctone.
Moreover, Piroctone Olamine is a white crystalline powder, sometimes slightly yellowish, with a faint distinctive odor.
Piroctone Olamine is used for it’s anti-dandruff, anti-bacterial and also anti-odor/fungal properties.
Piroctone Olamine’s what makes anti-dandruff dermatological products effective (shampoos & hair tonics).
In addition, Piroctone Olamine eliminates offensive body odor and is a thickening preservation.



BENEFITS OF PIROCTONE OLAMINE:
*Hair conditioning, frizz control,
*Hair strength / repair, anti-split ends,
*Anti-Dandruff,
*Anti-microbial, sanitizing,
*Antioxidant



FUNCTIONS OF PIROCTONE OLAMINE:
*Anti dandruff :
Piroctone Olamine helps fight against dandruff
*Preservative :
Piroctone Olamine inhibits the development of microorganisms in cosmetic products.



BENEFITS OF PIROCTONE OLAMINE:
1. Cures Dandruff
Malassezia Globosa is not a friendly fungus found in your scalp.
It is the main reason behind scalp issues like dandruff and seborrheic dermatitis.

Your scalp becomes irritated and starts shedding tiny flakes.
In severe cases, you will notice inflammation, redness, and extremely itchy patches.

If you want to prevent your scalp from worsening, it’s essential to control the situation promptly.
Piroctone Olamine has antifungal properties, which will help you control the spread of Malassezia globosa.
Use an anti-dandruff shampoo containing piroctone olamine to fight dandruff.


2. Prevents Hair Loss
Regardless of your gender and age, you may face hair fall, mostly caused due to dirt, dust, pollution, dandruff, excessive use of hair styling tools, etc.
Dandruff makes your scalp itchy, which leads to constant scratching, redness, and hair follicle damage.

Even though hair fall due to dandruff is not a significant concern but in people with androgenic alopecia (a condition that leads to baldness), Piroctone Olamine is a proven cure for reducing hair fall.
As it effectively works on dandruff and fungal infections, naturally, your hair loss decreases over time.


3. Boosts Hair Growth
Piroctone Olamine encourages hair growth in many ways.
Piroctone Olamine reduces hair fall and increases the hair diameter.

It is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone Olamine provides better results for dandruff and fungal infections.



ORIGIN OF PIROCTONE OLAMINE:
Piroctone Olamine is of petrochemical origin and helps treat dandruff.
There is no natural alternative that comes close to being as effective as this.



PHYSICAL and CHEMICAL PROPERTIES of PIROCTONE OLAMINE:
Water Solubility: 0.351 mg/mL
logP: 3.77
logS: -2.8
pKa (Strongest Acidic): 6.87
pKa (Strongest Basic): -6.4
Physiological Charge: -1
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 40.54 Ų
Rotatable Bond Count: 5
Refractivity: 71.81 m³·mol⁻¹
Polarizability: 27.69 ų
Number of Rings: 1
Bioavailability: 1
Rule of Five: Yes

Ghose Filter: Yes
Veber's Rule: No
MDDR-like Rule: No
Physical State: Solid
Storage: Store at 4°C
Melting Point: 130-136°C
MDL Number: MFCD01690792
Molecular Weight: 298.4267 g/mol
Chemical Formula: C16H30N2O3
Assay: 95.00 to 100.00%
Food Chemicals Codex Listed: No
Boiling Point: 344.10°C at 760.00 mm Hg (estimated)
Vapor Pressure: 0.000004 mmHg at 25.00°C (estimated)

Flash Point: 323.00°F TCC (161.90°C) (estimated)
logP (o/w): 3.696 (estimated)
Soluble in: water, 18.75 mg/L at 25°C (estimated)
Boiling Point: 344.1°C
Melting Point: 130-135°C
pH: 8.5-10.0
Solubility: Slightly soluble in water
Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Topological Polar Surface Area: 86.8Ų
Physical State: Powder
Color: White
Odor: Weak

Melting Point/Freezing Point: 132°C at 1.013 hPa
Initial Boiling Point and Boiling Range: 130-135°C (ECHA)
Flash Point: 161.9°C Pensky-Martens closed cup
Autoignition Temperature: >430°C at 1.013 hPa
pH: 8.5 at 25°C (saturated solution)
Water Solubility: Approximately 0.0298 g/l at 20°C - slightly soluble
Partition Coefficient (n-Octanol/Water): Log Pow: 3.86 at 20.5°C
Vapor Pressure: Density: 1.1 g/cm³ at 21.5°C
Relative Density: 1.1 at 21.5°C
Chemical Name: Piroctone ethanolamine
CAS No.: 68890-66-4
EINECS No.: 272-574-2

Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.4 g/mol
Appearance: White or slightly yellow crystalline powder
Purity (HPLC): ≥99.0%
PH Value (1% aqueous suspension, 20°C): 9.0-10.0
Melting Point (ºC): 133-136°C
Weight Average: 298.427
Monoisotopic: 298.225642834
Chemical Formula: C16H30N2O3
InChI Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
IUPAC Name: 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
SMILES: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C



FIRST AID MEASURES of PIROCTONE OLAMINE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PIROCTONE OLAMINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of PIROCTONE OLAMINE:
Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system



EXPOSURE CONTROLS/PERSONAL PROTECTION of PIROCTONE OLAMINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PIROCTONE OLAMINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions.
Tightly closed.
Dry.
Storage class



STABILITY and REACTIVITY of PIROCTONE OLAMINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .

Piroctone olamine cosmetic grade is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Piroctone olamine cosmetic grade is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone olamine cosmetic grade is a compound, which is often used to cure fungal infections.

CAS Number: 68890-66-4
Molecular Formula: C16H30N2O3
Molecular Weight: 298.43
EINECS Number: 272-574-2

PIROCTONE OLAMINE, 68890-66-4, Octopirox, Piroctone ethanolamine, Kopirox, Octopyrox, Piroctoneolamine, Piroctone ethanolamine salt, Piroctone olamine [USAN], UNII-A4V5C6R9FB, EINECS 272-574-2, A4V5C6R9FB, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, NSC-759894, PIROCTONE ETHANOLAMINE SALT (1:1), EC 272-574-2, NSC 759894, Piroctone olamine (USAN), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, PIROCTONE OLAMINE (MART.), PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE (USP-RS), PIROCTONE OLAMINE [USP-RS], 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, DTXCID2026735, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Allermyl, Keratolux, Octopirox (TN), SCHEMBL2843, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), CHEMBL2107154, PIROCTONE OLAMINE [INCI], AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone olamine, analytical standard, AKOS025149526, CCG-267454, CS-7659, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, FT-0653357, P2178, D05505, Piroctone ethanolamine salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine

Piroctone olamine cosmetic grade belongs to the class of hydroxypyridone antimycotics.
Shampoos with Piroctone Olamine are very effective in curing dandruff and preventing hair loss.
This ingredient has anti-fungal properties and appears as a crystalline powder in its raw form that is white or slightly yellow in color.

Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Further, Piroctone olamine cosmetic grade is slightly soluble in oil and water.
The chemical formula of Piroctone olamine cosmetic gradee is C16H30N2O3.

Piroctone olamine cosmetic grade is an antifungal and antibacterial agent that is commonly used in cosmetic and personal care products.
This salt is a hydroxamic acid derivative Piroctone.

One in every three persons suffers from a problem related to their hair.
Piroctone olamine cosmetic grade is a pyridone derivative, which is known to have bactericidal effects on gram-positive and gram-negative bacteria and fungicidal effects and hence is a component of many cosmetic products such as anti-dandruff shampoo.

Piroctone olamine cosmetic grade is structurally similar to Ciclopirox and Pyrithione.
Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative Octopirox.

Piroctone olamine cosmetic grade produced at Gujarat based facility has bacteriostatic and fungistatic properties.
A target of this product is Pityrosporumovale, which is present on the skin and causes dandruff, as well as flaking on the face and scalp.
Piroctone olamine cosmetic grade replaces Zinc Pyrithione in shampoos.

Piroctone olamine cosmetic grade a preservative and thickening agent, it is used in all types of personal care products.
Piroctone olamine cosmetic grade offered by COSROMA is called Cosroma OCT.
Piroctone olamine cosmetic grade, which is an ethanolamine salt of pyrrolidone hydroxamic acid derivative.

Piroctone olamine cosmetic grade is famous for its bacteriostatic effect, especially for inhibiting Plasmodium ovale parasitism in dandruff, face, and other dandruff.
Piroctone olamine cosmetic grade is usually used in shampoo instead of ZPT.
Piroctone olamine cosmetic grade has been used in personal care products for more than 30 years, as well as preservatives and thickeners.

In a controlled clinical trial, the results showed that Piroctone olamine cosmetic grade was superior to ketoconazole and pyridine-thione zinc in the treatment of androgen-induced hair loss by improving hair core; At the same time, Piroctone Olamine can reduce oil secretion.
Piroctone olamine cosmetic grade is a white to off-white crystalline powder with a very faint odor.
Piroctone olamine cosmetic grade is insoluble in water, mineral oil, and isopropylene; and soluble in ethanol and propylene glycol.

Piroctone olamine cosmetic grade is a remarkably effective anti-dandruff agent almost nontoxic ingredient for haircare products and clear shampoo.
Piroctone olamine cosmetic grade is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.
Piroctone olamine cosmetic grade is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products.

Piroctone olamine cosmetic grade exhibits low toxicity, low irritation, and excellent efficacy in hair care applications.
In addition, Piroctone olamine cosmetic grade has good pH and thermal stability, solubility in surfactant systems, and good compatibility with other ingredients.
Piroctone olamine cosmetic grade is one of the most efficient anti-dandruff actives available on the market today.

Designed specifically to treat seborrheic dermatitis and dry scalp, Piroctone olamine cosmetic grade offers additional benefits: it is environmentally friendly, multifunctional (doubles as preserving agent), and can be used in various cosmetic formats.
Piroctone olamine cosmetic grade is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products such as shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade is extremely easy to formulate, enabling stable formulations with no effort.
Piroctone olamine cosmetic grade controls the growth of microorganisms effectively and is directly targeting the cause of dandruff.
Piroctone olamine cosmetic grade is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade is one of the most efficient anti-dandruff actives available on the market today.
Designed specifically to treat seborrheic dermatitis and dry scalp, piroctone olamine offers additional benefits: it is environmentally friendly, multifunctional (doubles as preserving agent), and can be used in various cosmetic formats.
Piroctone olamine cosmetic grade is a compound sometimes used in the treatment of fungal infections.

Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Piroctone olamine cosmetic grade has a petrochemical origin. It is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.
Typically, Piroctone olamine cosmetic grade is an alternative to the commonly used compound zinc pyrithione.

Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing Piroctone olamine cosmetic grade are effective in treating various kinds of hair problems.
Microorganisms such as Malassezia Furfur produce enzymes which decompose fats into the respective fatty acids.

These and further decomposition products like lipo-peroxides irritate the scalp.
As a result, increased production of keratinocytes and increased mitosis occur which leads to desquamation and occurrence of parakeratosis.
Piroctone olamine cosmetic grade controls the growth of microorganisms effectively and is directly targeting the cause of dandruff.

Use Piroctone olamine cosmetic grade concentration can be chosen between 0.1 and 1.0%, depending on the finished product.
For leave-on products, the concentration can be lowered to 0.05 and 0.1%.
Piroctone olamine cosmetic grade is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products such as shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione.
Piroctone olamine cosmetic grade is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.
Piroctone olamine cosmetic grade is an effective, practically nontoxic antidandruff active ingredient.

Piroctone olamine cosmetic grade is a trade name for a chemical compound known as Piroctone Olamine.
Piroctone olamine cosmetic grade is an antifungal agent that is commonly used in anti-dandruff shampoos and other personal care products.
Piroctone olamine cosmetic grade and climbazole are widely used in the formulation of antidandruff shampoos, imported or produced inside country and no sideeffects have been reported yet.

There are no studies in publication that have compared the efficacy of these two substances in controlled conditions among human beings.
Herbal extracts because of some special properties such as hair fortifying and anti hair loss effects in addition to their less side effects, lower costs and being more available are also now increasingly used in shampoos.
There are few studies that have evaluated herbal extracts besides chemicals and there is no document dealing with cross reactions between them and their effects on clinical efficacy.

In this study, we aimed to compare clinical efficacy of climbazole with Piroctone olamine cosmetic grade in the treatment of dandruff and seborrheic dermatitis in shampoos with herbal extracts.
Piroctone olamine cosmetic grade is known for its ability to combat the growth of fungi, including the yeast Malassezia furfur, which is associated with dandruff and certain skin conditions.
Piroctone olamine cosmetic grade is well-known for its antibacterial effect and is often used in shampoos to replace ZPT( zinc pyrithione).

Piroctone olamine cosmetic grade has been used in personal care products for more than 30 years.
Piroctone olamine cosmetic grade is also used as a preservative and thickener.
Compared with other anti-dandruff agents, Piroctone olamine cosmetic grade has lower toxicity, excellent solubility, and compounding properties.

Piroctone olamine cosmetic grade will not cause precipitation or delamination when mixed with other cosmetic raw materials.
Piroctone olamine cosmetic grade has low irritation and will not cause hair loss.
In a controlled clinical trial, the results showed that Piroctone olamine cosmetic grade is superior to ketoconazole and zinc pyrithione, and Piroctone Olamine can reduce oil secretion.

Piroctone olamine cosmetic grade is the only anti-dandruff and antipruritic agent in the world that can be used as a Wash-Free product.
Piroctone olamine cosmetic grade is through the methods of sterilization, antibacterial, anti-oxidation, and decomposition of oxides to fundamentally block the external factors caused by dandruff, effectively eradicate dandruff, and stop itching.
Piroctone olamine cosmetic grade is primarily used in cosmetic formulations for its antimicrobial properties.

Piroctone olamine cosmetic grade helps inhibit the growth of fungi and bacteria, making it beneficial in products where preventing microbial contamination is important.
Piroctone olamine cosmetic grade is commonly found in various cosmetic and personal care products such as shampoos, conditioners, hair tonics, scalp treatments, skin creams, lotions, and other skincare formulations.
Piroctone olamine cosmetic grade is often used in anti-dandruff shampoos due to its ability to address conditions associated with dandruff and flaky scalp.

Piroctone olamine cosmetic grade helps control the growth of the yeast Malassezia, which is linked to dandruff.
Piroctone olamine cosmetic grade can be included to provide antimicrobial benefits, helping to maintain the microbial balance on the skin and prevent issues related to bacterial or fungal overgrowth.
Piroctone olamine cosmetic grade is used in products that aim to address conditions such as itching, redness, or discomfort associated with scalp issues.

Piroctone olamine cosmetic grade can act as a preservative in cosmetic formulations, contributing to the overall stability and shelf life of the product by preventing the growth of microorganisms.
Piroctone olamine cosmetic grade should comply with regulatory standards and guidelines for cosmetic ingredients.
Piroctone olamine cosmetic grade undergoes safety assessments to ensure its suitability for use in personal care products.

Piroctone olamine cosmetic grade is generally compatible with various formulations and can be used alongside other cosmetic ingredients without significant compatibility issues.
Piroctone olamine cosmetic grade is effective in a broad pH range, making it suitable for use in formulations with different acidity or alkalinity levels.
Piroctone olamine cosmetic grade is often included in cosmetic products targeting specific skin or hair concerns, and its use is often communicated to consumers as part of the product's beneficial properties.

Piroctone olamine cosmetic grade by Clariant is a highly effective anti-dandruff and antimicrobial agent.
Piroctone olamine cosmetic grade is an environmental friendly and multifunctional (doubles as a preserving agent).
Piroctone olamine cosmetic grade is an effective, nontoxic anti-dandruff active ingredient.

Piroctone olamine cosmetic grade is particularly suitable for the manufacture of anti-dandruff shampoos and hair care products such as hair tonics and cream rinses.
Microorganisms such as Malassezia furfur produce enzymes which decompose fats into their respective fatty acids.
These and other products of decomposition, such as lipo-peroxides, irritate the scalp.

As a result, mitosis and production of keratinocytes increases, leading to desquamation and parakeratosis.
Piroctone olamine cosmetic grade controls the growth of microorganisms effectively and directly targets the cause of dandruff.
Use concentration can be between 0.1 and 1.0%, depending on the finished product.

For leave-on products,the concentration can be lowered to between 0.05 and 0.1%.
Piroctone olamine cosmetic grade has low aquatic toxicity and broad-spectrum preservation.
Piroctone olamine cosmetic grade is sensitive towards UV light and might be decomposed depending on the amount of irradiation.

Piroctone olamine cosmetic grade is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative piroctone was first synthesized in 1979 by Schwarzkopf-Henkel (Germany).
Piroctone olamine cosmetic grade is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione which was banned in the EU in 2021 because of concerns for environmental toxicity.

Piroctone olamine cosmetic grade is basically an ethanolamine salt that is derived from Piroctone - which is a derivative of hydroxamic acid.
Piroctone olamine cosmetic grade appears as a crystalline white powder with a faint distinctive odor.
Piroctone olamine cosmetic grade is expressly approved and/or subject to a restriction as a result of an entry in Annex III of the EC Cosmetics Regulation after an assessment by the Scientific Committee on Consumer Safety of the EU Commission (SCCS).

Restrictions can relate eg to purity criteria, a maximum concentration or the restriction to certain product categories.
Subject to the conditions possibly imposed in Annex III, the use of this substance in cosmetic products is safe.
Piroctone olamine cosmetic grade and climbazole are widely used in the formulation of antidandruff shampoos, imported or produced inside country and no sideeffects have been reported yet.

There are no studies in publication that have compared the efficacy of these two substances in controlled conditions among human beings.
Herbal extracts because of some special properties such as hair fortifying and anti hair loss effects in addition to their less side effects, lower costs and being more available are also now increasingly used in shampoos.
There are few studies that have evaluated herbal extracts besides chemicals and there is no document dealing with cross reactions between them and their effects on clinical efficacy.

Piroctone olamine cosmetic grade is one of the more recent active ingredients found in dandruff shampoos.
Designed to treat seborrheic dermatitis and dry scalp piroctone olamine is one of the most innovative areas of dandruff treatment on the market today. W
Piroctone olamine cosmetic grade is widely available globally, and its use is not limited to specific regions.

Cosmetic manufacturers may incorporate Piroctone olamine cosmetic grade into formulations for products distributed internationally.
Piroctone olamine cosmetic grade is typically colorless and odorless, which makes it suitable for use in cosmetic products without affecting the color or fragrance of the final formulation.
Piroctone olamine cosmetic grade is often included in leave-in hair treatments, such as serums or leave-on scalp treatments, providing a prolonged exposure to its beneficial properties.

Piroctone olamine cosmetic grade may be used in various cleansing products, including facial cleansers or body washes, where its antimicrobial properties contribute to maintaining skin health during cleansing.
In addition to personal care products, Piroctone olamine cosmetic grade can be found in certain hygiene products, such as intimate washes or antibacterial cleansers.
Piroctone olamine cosmetic grade adheres to quality standards set by regulatory bodies and industry organizations to ensure consistency and safety in cosmetic formulations.

Melting point: 134.0 to 138.0 °C
Boiling point: 135-235℃[at 101 325 Pa]
Density: 1.1[at 20℃]
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
pka: 5.9-7.4[at 20 ℃]
form: neat
color: White to Off-White
Water Solubility: 400-50000mg/L at 20-25℃
Merck: 14,7502
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey: BTSZTGGZJQFALU-UHFFFAOYSA-N
SMILES: C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C
LogP: 1.05-3.86 at 20-25℃

Cosmetics often contain more than one preservative substances and these preservative systems act simultaneously against different bacteria, yeasts or moulds.
Each of these substances has been comprehensively tested and assessed for safety (individually and in combination).
Manufacturers always use only the lowest possible effective concentration in a product so that an optimum shelf life and safe application are ensured.

Piroctone olamine cosmetic grade is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.
Piroctone olamine cosmetic grade has a petrochemical origin.
Piroctone olamine cosmetic grade is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.

Typically, Piroctone olamine cosmetic grade is an alternative to the commonly used compound zinc pyrithione.
Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing piroctone olamine are effective in treating various kinds of hair problems.

Piroctone olamine cosmetic grade gives clear, transparent, pH- and temperature stable formulation.
Piroctone olamine cosmetic grade can be used together with most cationic surfactants and active ingredients.
Piroctone olamine cosmetic grade is an effective, practically nontoxic antidandruff active ingredient.

Piroctone olamine cosmetic grade is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.
Under the brand name Piroctone olamine cosmetic grade, it was used for the first time in July 1979 in the Seborin produced by Schwarzkopf & Henkel Düsseldorf (subsidiary of Hoechst).
Now-a-days, the Piroctone olamine cosmetic grade is present in many cosmetic products for the treatment of dandruff (Pityriasis simplex capillitii), like shampoos, even for dogs and cats.

Piroctone olamine cosmetic grade has fungicidal activity against all medically relevant dermatophytes, yeasts and mold fungi, due to penetration into the cell wall of yeast, fungi such as
Malassezia furfur and complexation with iron (III) ions, which results in an inhibition of the energy metabolism in the mitochondria of the fungi.
The concentrations should be between 0.1 and 1.0%, depending on the type of final product, or should be further reduced for preparations that remain on the hair or the scalp.
Minimum inhibition concentration for the most important species of fungi lies between 0.5 and 4.0 µg/ml.

In addition to the fungicidal activity, Piroctone olamine cosmetic grade also exhibits a bactericidal activity against gram-positive and gram- negative bacteria in 0.1-3.0% concentration in personal care compositions.
Moreover, in vitro model of experimental onychomycosis caused by T. rubrum pointed out a possible role of 0.5% Piroctone olamine cosmetic grade nail lacquer as a preventive tool for subjects at risk or as a curative tool in the first stage of onychomycosis
Piroctone olamine cosmetic grade is present as free acid in neutral solutions and is chemically stable over a wide pH range.

Piroctone olamine cosmetic grade is compatible with most surfactants, additives and active ingredients.
Piroctone olamine cosmetic grade is gentle on the scalp and causes no flake and itching.
Piroctone olamine cosmetic grade encourages hair growth in many ways. It reduces hair fall and increases the hair diameter.

Piroctone olamine cosmetic grade is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone olamine cosmetic grade provides better results for dandruff and fungal infections.
Piroctone olamine cosmetic grade is suitable for shampoo, conditioner, scalp tonic, cream rinse and hair styling products.
Recommended for roll-on, spray, foot deodorant cream and stick.

Piroctone olamine cosmetic grade has anti-fungal as well as anti-dandruff activity making it ideal for a range of products for dry skin.
Piroctone olamine cosmetic grade can be quickly degraded after being absorbed by the skin, it won't accumulate and has no side effects on the skin.
At the same time, the irritation of piroctone olamine is very small, study shows irritation to the skin is not significantly increased compared with the placebo shampoo.

Moreover, Piroctone olamine cosmetic grade can quickly combine with the iron ions in the water to lose its original toxicity, and cause less harm to aquatic organisms.
People in the world attach great importance to the safety of anti-dandruff agents.
Piroctone olamine cosmetic grade has the lowest toxicity index among similar anti-dandruff agents.

Piroctone olamine cosmetic grade's the only agent that could be used in leave-on products such as hair cream, hair spray, mousse, and hair dye.
Piroctone olamine cosmetic grade is generally considered mild on the skin, and it is suitable for use in products intended for sensitive or reactive skin.
In addition to its antimicrobial effects, Piroctone olamine cosmetic grade may contribute to the soothing of irritated skin or scalp, making it beneficial in formulations designed for addressing redness or inflammation.

Piroctone olamine cosmetic grade is commonly used in various hair care products beyond shampoos, such as conditioners, hair masks, and tonics, contributing to scalp health and overall hair care.
Piroctone olamine cosmetic grade can be found in leave-on products like creams and lotions, where its antimicrobial properties help maintain skin health over extended periods.
Piroctone olamine cosmetic grade is often formulated alongside other active ingredients, such as anti-inflammatory agents or moisturizers, to create comprehensive solutions for specific skincare concerns.

Dermatologists may recommend products containing Piroctone olamine cosmetic grade as part of skincare regimens for individuals with conditions like seborrheic dermatitis or psoriasis.
Some formulations containing Piroctone olamine cosmetic grade may be supported by clinical studies demonstrating their efficacy in addressing specific skin or scalp conditions.
Piroctone olamine cosmetic grade used in products intended for sale in different regions complies with the respective regulatory standards and guidelines in those regions.

Piroctone olamine cosmetic grade exhibits good stability in various cosmetic formulations, contributing to the overall efficacy and performance of the product over time.
As the cosmetic industry evolves, Piroctone olamine cosmetic grade may be part of innovative formulations that combine it with other cutting-edge ingredients to address emerging consumer preferences and trends.
Given its antimicrobial properties, the choice of packaging for products containing Piroctone olamine cosmetic grade may be influenced to ensure the product's stability and prevent contamination.

Cosmetic companies may include information about Piroctone olamine cosmetic grade in their marketing materials, educating consumers about its benefits and how it addresses specific skincare or hair care concerns.
Piroctone olamine cosmetic grade is commonly used in rinse-off products, like shampoos or body washes, where it helps cleanse the skin or scalp while providing antimicrobial benefits.
Cosmetic manufacturers may consider the sustainability aspects of Piroctone Olamine sourcing and production, aligning with the growing consumer demand for sustainable and eco-friendly ingredients.

Products containing Piroctone Olamine may cater to consumer preferences for effective yet gentle solutions, especially in formulations targeting sensitive or problematic skin.
Piroctone olamine cosmetic grade's compatibility with various formulation types allows cosmetic formulators flexibility in creating products with different textures and applications.
Piroctone olamine cosmetic grade is often included in formulations that promote holistic scalp care, addressing issues such as dandruff, itching, and maintaining a healthy scalp environment.

Some formulations with Piroctone olamine cosmetic grade may be recommended by dermatologists or skincare professionals for individuals with specific skin or scalp concerns.
Piroctone olamine cosmetic grade may work synergistically with other active ingredients, enhancing the overall efficacy of a cosmetic formulation.

Uses:
Piroctone olamine cosmetic grade is quite beneficial in maintaining cosmetic and personal care products.
Piroctone olamine cosmetic grade can commonly be found in products like shampoos, cleansers, and hair masks.
Piroctone olamine cosmetic grade can be used to eliminate the bad odor from the surface of the skin.

Piroctone olamine cosmetic grade is a great preservative that helps in keeping skin care products free from bacterial growth.
Piroctone olamine cosmetic grade is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone olamine cosmetic grade is also good for preventing hair loss and split ends.

In cosmetic products, Piroctone olamine cosmetic grade makes use of its antifungal properties to keep the products free from unwanted bacterial growth for a longer time.
The addition of Piroctone olamine cosmetic grade improves the quality of the products and makes them last longer
Piroctone olamine cosmetic grade is frequently incorporated into anti-dandruff shampoos.

Piroctone olamine cosmetic grade helps control the growth of the yeast Malassezia, which is associated with dandruff, and supports a healthy scalp.
Piroctone olamine cosmetic grade is used in various scalp treatments and tonics designed to address conditions such as itching, flaking, and redness associated with scalp issues.
Piroctone olamine cosmetic grade can be found in hair conditioners to provide both scalp and hair care benefits.

Piroctone olamine cosmetic grade is antimicrobial properties contribute to a healthy scalp, while its conditioning effects enhance the manageability of hair.
Piroctone olamine cosmetic grade is included in leave-on hair products like serums or creams, where its prolonged contact with the scalp can contribute to ongoing scalp health and comfort.
Piroctone olamine cosmetic grade is used in skincare formulations such as creams and lotions.

Piroctone olamine cosmetic grade is antimicrobial properties can help maintain skin health, and it may be included in products designed for sensitive or reactive skin.
In body washes and cleansers, Piroctone olamine cosmetic grade contributes to cleansing while providing antimicrobial benefits, making it suitable for maintaining skin hygiene.
Some facial cleansers targeted at addressing specific skin concerns, such as acne or seborrheic dermatitis, may contain Piroctone olamine cosmetic grade for its antimicrobial properties.

Piroctone olamine cosmetic grade may be found in certain hygiene products, such as intimate washes or antibacterial cleansers, where its antimicrobial effects are beneficial.
Piroctone olamine cosmetic grade is included in leave-on skincare treatments like serums or spot treatments, contributing to the overall health and balance of the skin.
Piroctone olamine cosmetic grade is used in moisturizers, contributing to the formulation's overall skin-conditioning properties.

Due to its mild and gentle nature, Piroctone olamine cosmetic grade is suitable for use in products designed for individuals with sensitive or reactive skin.
In some formulations aimed at addressing acne or blemishes, Piroctone olamine cosmetic grade's antimicrobial properties may contribute to maintaining a clearer complexion.
Piroctone olamine cosmetic grade may be included in personal care wipes to provide antimicrobial benefits and contribute to a refreshing and hygienic experience.

Piroctone olamine cosmetic grade is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone olamine cosmetic grade could induce apoptosis and possessed a significant in vivo effect against myeloma.
Piroctone olamine cosmetic grade, the ethanolamine salt is formed as a result of hydroxamic acid.

This ingredient is often used as a substitute for zinc pyrithione in anti-dandruff shampoos.
Seborrheic dermatitis and dandruff have been linked to hair shedding and hair thinning.
Based on a clinical study, it was revealed that Piroctone olamine cosmetic grade was more efficient than Ketoconazole or Zinc Pyrithione in thickening hair shafts in androgenic alopecia.

Piroctone olamine cosmetic grade reduces the production of sebum.
Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative of piroctone.
Piroctone olamine cosmetic grade's anti-fungal and anti-inflammatory properties may contribute to its inclusion in formulations aimed at alleviating scalp itchiness.

Piroctone olamine cosmetic grade can be found in products designed to provide relief for individuals with itchy scalps.
Due to its mild nature, Piroctone olamine cosmetic grade is suitable for individuals with sensitive skin.
Piroctone olamine cosmetic grade is often chosen for formulations that need to address specific skin conditions without causing irritation.

Piroctone olamine cosmetic grade's mildness and efficacy make it suitable for daily use in various hair care and skincare products.
Piroctone olamine cosmetic grade can be included in formulations designed for regular use without causing excessive dryness or irritation.
Piroctone olamine cosmetic grade is sometimes used in combination with other active ingredients in hair care products.

Piroctone olamine cosmetic grade with other agents, such as anti-inflammatory or soothing ingredients, can enhance the overall performance of the formulation.
Regular use of Piroctone olamine cosmetic grade-containing shampoos and hair care products can serve as a preventive measure against dandruff, scalp irritation, and fungal growth.
Piroctone olamine cosmetic grade is often included in products that aim to maintain a healthy scalp environment.

Piroctone olamine cosmetic grade's compatibility with various cosmetic formulations contributes to the overall sensory experience of the product.
Piroctone olamine cosmetic grade is chosen for its ability to maintain the product's texture, appearance, and scent.
Piroctone olamine cosmetic grade may be incorporated into specialized scalp serums designed to address specific concerns such as dryness, flakiness, or sensitivity.

Ongoing research may explore new formulations and applications of Piroctone olamine cosmetic grade.
Clinical studies may investigate its efficacy in different contexts and conditions related to the scalp and skin.
Dermatologists may recommend products containing Piroctone olamine cosmetic grade for individuals with specific scalp conditions or concerns.

Piroctone olamine cosmetic grade is often included in dermatologist-recommended hair care regimens.
Piroctone olamine cosmetic grade is known for its versatility and compatibility with different hair types, making it a popular choice for inclusion in a wide range of hair care products.
Piroctone olamine cosmetic grade is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.

Recently was shown, that Piroctone olamine cosmetic grade could induce apoptosis and possessed a significant in vivo effect against myeloma.
Generally, the solubility of Piroctone olamine cosmetic grade is highly depending on the pH value of the solution.
As a rule of thumb, it is better dissolved in neutral and slightly alkaline aqueous solutions than in acidic solutions.

Piroctone olamine cosmetic grade is possible to dissolve between pH=5 to pH=8 in surfactant
Piroctone olamine cosmetic grade can also be used in anti-acne products such as gel, lotion and cleanser.
Piroctone olamine cosmetic grade is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade used for shampoos, and hair care products such as hair tonics and cream rinses.
Piroctone olamine cosmetic grade is a key ingredient in antidandruff shampoos.
Piroctone olamine cosmetic grade may be included in deodorant formulations for its antimicrobial properties, helping to control the growth of odor-causing bacteria.

In foot creams and balms, Piroctone olamine cosmetic grade can contribute to maintaining foot hygiene by preventing the proliferation of microorganisms associated with unpleasant odors and skin conditions.
Piroctone olamine cosmetic grade is used in certain intimate care products, such as washes and wipes, providing antimicrobial benefits in delicate areas while being gentle on the skin.
Some sunscreen formulations may include Piroctone olamine cosmetic grade for its antimicrobial effects, especially in products designed for use in humid or warm conditions.

Piroctone olamine cosmetic grade may be found in acne spot treatments, where its antimicrobial properties are utilized to target and address specific blemishes.
In after-sun lotions or creams, Piroctone olamine cosmetic grade can contribute to skin comfort and hygiene after exposure to the sun.
Certain baby lotions, creams, or wipes may contain Piroctone olamine cosmetic grade to provide mild antimicrobial benefits while being suitable for sensitive baby skin.

Piroctone olamine cosmetic grade may be included in cosmetic primers to contribute to skin health and hygiene as part of the makeup application routine.
Due to its antimicrobial properties, Piroctone olamine cosmetic grade may be used in barrier creams designed to protect the skin from external factors while maintaining skin health.
In tinted moisturizers, Piroctone olamine cosmetic grade can provide not only moisturization but also contribute to maintaining a balanced and healthy complexion.

Piroctone olamine cosmetic grade might be included in certain foundation formulations, contributing to the overall health of the skin while providing coverage.
Piroctone olamine cosmetic grade's antimicrobial properties can be beneficial in cosmetic sticks, helping to maintain the hygiene of the product during application.
Piroctone olamine cosmetic grade may be used in various men's grooming products, including shaving creams or aftershave lotions, contributing to skin health and hygiene.

As an emollient and antimicrobial agent, Piroctone olamine cosmetic grade is incorporated into cosmetic emulsions, contributing to product stability and skin benefits.
Some anti-aging formulations may contain Piroctone olamine cosmetic grade for its skin-conditioning properties in addition to addressing microbial concerns.
Piroctone olamine cosmetic grade can be found in various color cosmetic products, such as eyeshadows or blushes, contributing to product hygiene and skin health.

Safety profile:
Piroctone olamine cosmetic grade is safe for use when added under the recommended percentage usage - 0.1% for rinse-off products and 0.5% for leave-on products.
Piroctone olamine cosmetic grade suits all skin and hair types, however, a patch test should be performed before full application.
Lastly, Piroctone olamine cosmetic grade is not used in organic products because it is a chemical preservative.

While Piroctone olamine cosmetic grade is generally well-tolerated, some individuals may be sensitive or allergic to it.
Patch testing is advisable, especially for individuals with a history of skin sensitivity.
Direct contact with the eyes should be avoided, as it may cause irritation.

In case of accidental contact, rinsing the eyes thoroughly with water is recommended.
Inhalation of cosmetic products containing Piroctone olamine cosmetic grade should be minimized.
Adequate ventilation is important, particularly in occupational settings where exposure levels may be higher.

Cosmetic products are not intended for ingestion.
Ingesting products containing Piroctone olamine cosmetic grade is not recommended, and consumers should seek medical attention if ingestion occurs accidentally.

Pivaloyl chloride, also known as Trimethylacetic acid chloride, is a colorless and volatile liquid with a strong odor.
Pivaloyl chloride is a colorless to light yellow liquid with a pungent odor.
Pivaloyl chloride (PIVCL) is used in the production of pharmaceuticals and agrochemicals.

CAS Number: 3282-30-2
EC Number: 221-921-6
Chemical Formula: C5H9ClO
Molar Mass: 120.58 g·mol−1

Synonyms: Pivaloyl chloride, 3282-30-2, Trimethylacetyl chloride, 2,2-DIMETHYLPROPANOYL CHLORIDE, Propanoyl chloride, 2,2-dimethyl-, Pivalyl chloride, 2,2-Dimethylpropionyl chloride, Pivalic acid chloride, Pivalolyl chloride, pivalic chloride, Neopentanoyl chloride, 2,2-dimethyl-propionyl chloride, JQ82J0O21T, 2,2,2-trimethylacetyl chloride, DTXSID4027529, 2,2-dimethylpropionic acid chloride, pivaloylchloride, Pivaloyl chlorid, pivaloylchlorid, UNII-JQ82J0O21T, Pvaloyl chlorde, PivCl, pivaloyl-chloride, 2,2, Dimethyl-propanoyl chloride, tBuCOCl, Piv-Cl, t-BuCOCl, EINECS 221-921-6, UN2438, PVCL, trimethylacetylchloride, trimethylacetyl choride, trimehtylacetyl chloride, trimethyl acetylchloride, Trimethylacetyl-chloride, t-butylcarbonyl chloride, trimethylacetoyl chloride, Trimethyl acetyl chloride, (CH3)3CCOCl, tert-butylcarbonyl chloride, EC 221-921-6, Acetyl chloride, trimethyl-, SCHEMBL1404, trimethylacetic acid chloride, 2,2-dimethylpropanoylchloride, 2,2-dimethylpropionylchloride, 2,2,2-trimethylacetylchloride, 2,2-Dimethyl-propionylchloride, Trimethylacetyl chloride, 99%, DTXCID907529, TERT-BUTYL CHLORO KETONE, 2,2-dimethyl propanoyl chloride, CHEMBL3183814, 2,2-dimethylpropionicacid cloride, STR00119, ZINC1534960, Tox21_200646, BBL011382, MFCD00000709, STL146483, 2,2-Dimethyl-propionic acid chloride, AKOS000121190, UN 2438, NCGC00248779-01, NCGC00258200-01, 1,1-DIMETHYLETHANECARBONYL CHLORIDE, CAS-3282-30-2, FT-0652320, P0677, Pivaloyl chloride, purum, >=98.0% (GC), EN300-19178, Trimethylacetyl chloride [UN2438] [Poison], A821441, J-523982, Q2017164, F2190-0014, 2,2-Dimethylpropanoyl chloride [ACD/IUPAC Name], 2,2, Dimethylpropanoylchlorid [German] [ACD/IUPAC Name], 221-921-6 [EINECS], 3282-30-2 [RN], Chlorure de 2,2-diméthylpropanoyle [French] [ACD/IUPAC Name], Pivaloyl chloride, PIVALYL CHLORIDE, Propanoyl chloride, 2,2-dimethyl- [ACD/Index Name], Trimethylacetyl chloride, [503-30-0] [RN], 1,3-Propylene oxide, 102382 [Beilstein], 15722-48-2 [RN], 2,2,2-Trimethylacetyl chloride, 2,2-Dimethyl-propionyl chloride, 2,2-Dimethylpropionyl Chloride, 2,2-Dimethylpropionyl chloride, Trimethylacetyl chloride, Acetyl chloride, trimethyl-, Cyclooxabutane, MFCD00005167 [MDL number], Neopentanoyl chloride, Oxetane [ACD/Index Name] [ACD/IUPAC Name] [Wiki], PI-44939, Pivalic acid chloride, Pivalolyl chloride, PivaloylChloride, RQ6825000, STR00119, tert-Valeryl chloride, Trimethylacetyl chloride [UN2438] [Poison], Trimethylacetylchloride, Trimethylene Oxide, UN 2438

Pivaloyl chloride is a branched-chain acyl chloride.
Pivaloyl chloride was first made by Aleksandr Butlerov in 1874 by reacting pivalic acid with phosphorus pentachloride.

Pivaloyl chloride is used as an input in the manufacture of some drugs, insecticides and herbicides.

Pivaloyl chloride (PC) is a reactive compound that is used in the synthesis of pharmaceuticals, dyes, and other organic compounds.
Pivaloyl chloride can be used as a precursor to amides, which are important pharmacological agents.

PC undergoes chemiluminescence when reacted with hydrogen fluoride and potassium dichromate in the presence of an amide.
This reaction mechanism can be used to detect small amounts of PC in solution.
PC has been shown to have anti-inflammatory effects in autoimmune diseases and has been investigated for use as a cox-2 inhibitor.

Pivaloyl chloride, also known as Trimethylacetic acid chloride, is a colorless and volatile liquid with a strong odor.
Pivaloyl chloride is an alkylating reagent and is widely used in organic synthesis for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.
Pivaloyl chloride is also used in the manufacture of drugs, pesticides, and other compounds.

Pivaloyl chloride is a colorless to light yellow liquid with a pungent odor.
Pivaloyl chloride hydrolyses in the presence of water.

Pivaloyl chloride (PIVCL) is used in the production of pharmaceuticals and agrochemicals.

Pivaloyl chloride is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.
Pivaloyl chloride is used in formulation or re-packing, at industrial sites and in manufacturing.

Pivaloyl chloride is a natural product found in Rhodiola rosea with data available.
Pivaloyl chloride appears as colorless fuming liquid with a pungent odor.

Pivaloyl chloride is very toxic by inhalation, ingestion or skin absorption.
Pivaloyl chloride is fumes irritate the eyes and mucous membranes.
Pivaloyl chloride is corrosive to most metals and tissue.

Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria.
Pivaloyl chloride is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament.
In addition to this, Pivaloyl chloride is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine.

Pivaloyl chloride is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Pivaloyl chloride market an overview:
Pivaloyl chloride is classified as a harmful chemical with many restrictions on Pivaloyl chloride handling and storage.
Pivaloyl chloride is used as a building block in the pharmaceutical and agrochemical industry.

In pharmaceutical industries, Pivaloyl chloride serves as an important acylating reagent.
Pivaloyl chloride is a major raw material used in the synthesis of amides and lipids.

Different important drugs that are manufactured using Pivaloyl chloride are Benzylpenicillin, adrenaline, cefazolin, and other drugs.
In agrochemical industries, Pivaloyl chloride finds Pivaloyl chloride application in pesticide intermediates production.
The major product agrochemical obtained from Pivaloyl chloride is Chloropivaloyl chloride.

In chemical industries, Pivaloyl chlorides are used in the synthesis of ketones, amino groups, and anhydrides.

Pivaloyl chloride market dynamics:
The global consumption of Pivaloyl chlorides is mainly associated with the growth in pharmaceutical and agrochemical industries.
Which are the major drivers for the growth of the Pivaloyl chlorides market around the world.

The global Pivaloyl chloride market is consolidated to a few global and regional players only.
Major players in global Pivaloyl chloride markets are mainly from China and India.

These countries are global leaders of agrochemical substances.
The demand for agrochemicals in these regions is mainly accelerated due to the government's positive attitude towards agriculture.

The government of India has launched initiatives like Pradhan Mantri Krishi Sinchai Yojana(PMKSY), which helps to support farmers in these regions.
With these schemes, the government is targeting an increase in the country's revenue from agriculture sectors.

This positive attitude in the development of the agriculture sector will boost the global Pivaloyl chloride Market in these countries.
The same strategy is followed by various other developing countries of Asia and other parts of the world.

The fluctuating international currency has negative impacts on the Pivaloyl chloride market.
Pivaloyl chloride high flammability and corrosiveness have also raised the safety concerns for the manufacturer's Transportation of Pivaloyl chloride to involve high risk.
These are some of the restraining factors for the growth of the Pivaloyl chloride market.

Pivaloyl chloride market analysis:
Agrochemical industries have grown significantly in the Asia Pacific region due to the rising demand for food crops in these regions.
China and India are leading producers of the agrochemical, which is utilized in regional development in the agriculture sector.
Thus overall consumption Pivaloyl chlorides expected to witness significant growth in these regions.

The global Pivaloyl chloride market in China and India is experiencing higher growth due to several government inanities, which are encouraging the growth of agriculture in these regions.
Besides agrochemical industries, pharmaceuticals and chemical industries have shown significant growth in Asia Pacific regions, which leverages the global Pivaloyl chloride market.

The pharmaceutical industries have been growing at higher single digits CAGR in Europe and America.
Since the application of Pivaloyl chlorides is associated with drug manufacturing, the global Pivaloyl chlorides are expected to rise in these regions.
The agriculture sector being the least contributing sector to the country`s GDP of the United States, contributes a very less to global Pivaloyl chlorides market.

The Latin American & Middle East & Africa markets for Pivaloyl chloride will show stagnant growth in the forecast period due to limited growth in agrochemical and pharmaceutical industries in these regions.

Pivaloyl Chloride Market Snapshot (2022 to 2032):
The global pivaloyl chloride demand is anticipated to rise at a CAGR of 4.3% to 6% during the forecast period between 2022 and 2032.
Rising applications of pivaloyl chloride across pharmaceutical and agrochemical industries are driving growth in the global pivaloyl chloride market.

Pivaloyl Chloride, also called 2, 2- dimethyl propanol chloride, is a branded chain acyl chloride with a pungent odor.
Pivaloyl chloride is being increasingly used as a building block in agrochemical, pharmaceutical, and refining chemicals industries.

Over the years, pivaloyl chloride has become a commonly used intermediate for the production of agricultural chemicals like insecticides, herbicides, pesticides, pharmaceutical compounds, and in peroxy esters manufacturing.
The rapid expansion of the pharmaceutical industry triggered by the increasing prevalence of various chronic and infectious diseases, growing health awareness, and increasing spending on medicines is expected to push the demand for pivaloyl chloride during the forecast period.
Pivaloyl chloride is being extensively used to manufacture pharmaceutical products such as DPE, cefazolin, dipivefrin, aminobenzylpenicilin, cephalexin, and digitally epinephrine.

Driving Demand in Pivaloyl Chloride Market:
The rapid growth of end-use industries such as chemical, agrochemical, and pharmaceutical is a major factor driving the demand for pivaloyl chloride.

Pivaloyl chloride has become an ideal intermediate candidate for manufacturing a wide range of pharmaceutical and agrochemical products.

Factors such as a surge in diseases worldwide and increasing healthcare spending have ignited the growth of the pharmaceutical industry worldwide.
People are spending large amounts on pharmaceutical drugs.
As many of these pharmaceuticals are manufactured by using pivaloyl chloride as an intermediate, the rising dale for these products will eventually push the demand for pivaloyl chloride during the forecast period.

Similarly, rising concerns about food insecurity are prompting farmers to use agrochemicals like herbicides, fertilizers, pesticides, etc.
According to the Food and Agriculture Organization (FAO) of the United Nations, globally, hunger levels remained alarmingly high during 2021 with around 193 million people facing acute food insecurity.
This is acting as a catalyst for the growth of the pivaloyl chloride market and the trend is likely to continue during the forecast period.

Challenges Faced by the Pivaloyl Chloride Industry:
Despite multiple applications of pivaloyl chloride, there are certain factors that are limiting the growth of the pivaloyl chloride industry.
Some of these factors include the presence of stringent regulations pertaining to the use of insecticides and pesticides, the hazardous nature of pivaloyl chloride, and the availability of various alternative pharmaceutical and pesticide intermediates.

Various countries are introducing regulations on the excessive use of insecticides and pesticides as they are harmful to humans, animals, and the environment.
This in turn is creating major challenges for manufacturers of pivaloyl chloride.

Scientific Research Applications of Pivaloyl chloride:
Pivaloyl chloride is used in a variety of scientific research applications, such as the synthesis of peptides, the synthesis of heterocyclic compounds, and the synthesis of amines.
Pivaloyl chloride is also used in the synthesis of polymers, such as polystyrene and polyethylene.
In addition, Pivaloyl chloride is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Uses of Pivaloyl chloride:
Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria.
Pivaloyl chloride is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament.

In addition to this, Pivaloyl chloride is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine.
Pivaloyl chloride is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Pivaloyl chloride is used as a chemical intermediate.
Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria.

Pivaloyl chloride is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament.
In addition to this, Pivaloyl chloride is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine.

Pivaloyl chloride is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Uses at industrial sites:
Pivaloyl chloride has an industrial use resulting in manufacture of another substance (use of intermediates).
Pivaloyl chloride is used for the manufacture of: chemicals.
Release to the environment of Pivaloyl chloride can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).

Industry Uses:
Intermediate
Intermediates

General Manufacturing Information of Pivaloyl chloride:

Industry Processing Sectors:
All Other Basic Organic Chemical Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Pharmaceutical and Medicine Manufacturing

Synthesis Method of Pivaloyl chloride:
Pivaloyl chloride is synthesized from trimethylacetic acid and thionyl chloride.
The reaction is carried out in a sealed tube or flask at a temperature of 40-60°C.

The reaction is exothermic and the reaction is complete in about 2 hours.
The yield of the reaction is usually in the range of 75-95%.

Chemical Structure of Pivaloyl chloride:
A chemical structure of a molecule includes the arrangement of atoms and the chemical bonds that hold the atoms together.
The Pivaloyl chloride molecule contains a total of 15 bond(s).
There are 6 non-H bond(s), 1 multiple bond(s), 1 rotatable bond(s), 1 double bond(s) and 1 acyl halogenide(s) (aliphatic).

The 2D chemical structure image of Pivaloyl chloride is also called skeletal formula, which is the standard notation for organic molecules.
The carbon atoms in the chemical structure of Pivaloyl chloride are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated with enough hydrogen atoms to provide the carbon atom with four bonds.

The 3D chemical structure image of Pivaloyl chloride is based on the ball-and-stick model which displays both the three-dimensional position of the atoms and the bonds between them.
The radius of the spheres is therefore smaller than the rod lengths in order to provide a clearer view of the atoms and bonds throughout the chemical structure model of Pivaloyl chloride.

Reactivity Profile of Pivaloyl chloride:
Pivaloyl chloride is acidic.
Incompatible with bases (including amines), strong oxidizing agents, and alcohols.
May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts.

Handling and Storage of Pivaloyl chloride:

Nonfire Spill Response:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
All equipment used when handling Pivaloyl chloride must be grounded.

Do not touch or walk through spilled material.
Stop leak if you can do it without risk.

Prevent entry into waterways, sewers, basements or confined areas.
A vapor-suppressing foam may be used to reduce vapors.

SMALL SPILL:
Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal.
Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL:
Dike far ahead of liquid spill for later disposal.
Water spray may reduce vapor, but may not prevent ignition in closed spaces.

First Aid Measures of Pivaloyl chloride:
Call 911 or emergency medical service.
Ensure that medical personnel are aware of Pivaloyl chloride(s) involved and take precautions to protect themselves.

Move victim to fresh air if it can be done safely.
Give artificial respiration if victim is not breathing.

Do not perform mouth-to-mouth resuscitation if victim ingested or inhaled Pivaloyl chloride; wash face and mouth before giving artificial respiration.
Use a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.

In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
Wash skin with soap and water.

In case of burns, immediately cool affected skin for as long as possible with cold water.
Do not remove clothing if adhering to skin.

Keep victim calm and warm.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.

Fire Fighting of Pivaloyl chloride:
The majority of these products have a very low flash point.
Use of water spray when fighting fire may be inefficient.

Methanol (UN1230) will burn with an invisible flame.
Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE:
Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE:
Water spray, fog or alcohol-resistant foam.
If it can be done safely, move undamaged containers away from the area around the fire.

Dike runoff from fire control for later disposal.
Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS:
Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.

Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

For massive fire, use unmanned master stream devices or monitor nozzles.
If this is impossible, withdraw from area and let fire burn.

Accidental Release Measures of Pivaloyl chloride:

Isolation and Evacuation:

IMMEDIATE PRECAUTIONARY MEASURE:
Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

FIRE:
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Identifiers of Pivaloyl chloride:
CAS Number: 3282-30-2
Beilstein Reference: 102382
ChEMBL: ChEMBL3183814
ChemSpider: 56272
ECHA InfoCard: 100.019.929
EC Number: 221-921-6
PubChem CID: 62493
UNII: JQ82J0O21T
UN number: 2438
CompTox Dashboard (EPA): DTXSID4027529
InChI: InChI=1S/C5H9ClO/c1-5(2,3)4(6)7/h1-3H3
Key: JVSFQJZRHXAUGT-UHFFFAOYSA-N
SMILES: CC(C)(C)C(=O)Cl

Synonym(s): Pivaloyl chloride, Trimethylacetyl chloride
Linear Formula: (CH3)3CCOCl
CAS Number: 3282-30-2
Molecular Weight: 120.58
Beilstein: 385668
EC Number: 221-921-6
MDL number: MFCD00000709
PubChem Substance ID: 24900440
NACRES: NA.22

CAS number: 3282-30-2
EC number: 221-921-6
Hill Formula: C₅H₉ClO
Chemical formula: (CH₃)₃CCOCl
Molar Mass: 120.58 g/mol
HS Code: 2915 90 70

EC / List no.: 221-921-6
CAS no.: 3282-30-2
Mol. formula: C5H9ClO

Product Number: P0677
Purity / Analysis Method: >98.0%(T)
Molecular Formula / Molecular Weight: C5H9ClO = 120.58
Physical State (20 deg.C): Liquid
Storage Temperature: 0-10°C
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Moisture Sensitive,Heat Sensitive
CAS RN: 3282-30-2
Reaxys Registry Number: 385668
PubChem Substance ID: 125310048
SDBS (AIST Spectral DB): 2154
MDL Number: MFCD00000709

Properties of Pivaloyl chloride:
Chemical formula: C5H9ClO
Molar mass: 120.58 g·mol−1
Density: 0.985
Melting point: −57 °C (−71 °F; 216 K)
Boiling point: 105.5 °C (221.9 °F; 378.6 K)
Refractive index (nD): 1.412

Boiling point: 105 °C (1013 hPa)
Density: 0.98 g/cm3 (20 °C)
Explosion limit: 1.9 - 7.4 %(V)
Flash point: 13 °C
Ignition temperature: 455 °C
Melting Point: 87 - 88 °C
Vapor pressure: 38.59 hPa (20 °C)

Vapor density: >1 (vs air)
Quality Level: 200
Vapor pressure: 36 mmHg ( 20 °C)
Assay: 99%
Refractive index: n20/D 1.412 (lit.)
bp: 105-106 °C (lit.)
Density: 0.979 g/mL at 25 °C (lit.)
SMILES string: CC(C)(C)C(Cl)=O
InChI: 1S/C5H9ClO/c1-5(2,3)4(6)7/h1-3H3
InChI key: JVSFQJZRHXAUGT-UHFFFAOYSA-N

Molecular Weight: 120.58
XLogP3-AA: 2.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 1
Exact Mass: 120.0341926
Monoisotopic Mass: 120.0341926
Topological Polar Surface Area: 17.1 Ų
Heavy Atom Count: 7
Complexity: 80.6
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Pivaloyl chloride:
Assay (morpholine method): ≥ 98.0 %
Density (d 20 °C/ 4 °C): 0.979 - 0.982
Identity (IR): passes test

Related Products of Pivaloyl chloride:
1,1-Dimethoxybutane
(E)-6,6-Dimethyl-2-hept-1-en-4-yn-1-amine
2,2-dimethoxybutane
Dimethyl trans-3-Hexenedioate
Dimethyl Hydroxyaspartate, Mixture of Diastereomers

Names of Pivaloyl chloride:

Regulatory process names:
Pivaloyl chloride
Pivaloyl chloride
pivaloyl chloride
TRIMETHYLACETYL CHLORIDE
Directive, Annex II - RID

CAS names:
Propanoyl chloride
2,2-dimethyl-

IUPAC names:
2,2-Dimethylpropanoyl chloride
2,2-dimethylpropanoyl chloride
2,2-dimethylpropanoylchloride
2,2-dimethylpropionic acid chloride
Pivaloyl Chloride

Preferred IUPAC name:
2,2-Dimethylpropanoyl chloride

Trade names:
1,1-Dimethylethanecarbonyl chloride
2,2-Dimethylpropanoyl chloride
2,2-Dimethylpropionic acid chloride
2,2-Dimethylpropionyl chloride
Neopentanoyl chloride
Pivalic acid chloride
Pivalolyl chloride
pivaloyl chloride
Pivaloyl chloride (6CI, 7CI, 8CI)
Pivaloylchlorid
Pivalyl chloride
Propanoyl chloride, 2,2-dimethyl-
Propanoyl chloride, 2,2-dimethyl- (9CI)
tert-Butyl chloro ketone
tert-Butylcarbonyl chloride
Trimethylacetyl chloride

Other names:
Trimethylacetyl chloride
Pivaloyl chloride
Pivalyl chloride
neopentanoylchloride

Other identifier:
3282-30-2

Before you start thinking about the fruit that is part of the banana family, it’s important to note that Plantain Extract comes from a different species of this family.
The Plantain Extract used in skin care most often comes from the leaves of Plantago major, which is a low-growing perennial weed found throughout most of North America.


Cas Number: 85085-64-9
Einecs Number: 285-388-1
Chem/IUPAC Name: Plantago Lanceolata Leaf Extract is an extract of the leaves of the English Plantain, Plantago lanceolata L., Plantaginaceae


Plantago Extract is an extract of the leaves of the plantain, Plantago lanceolata, Plantaginaceae.
Plantain is native to temperate Eurasia and has since spread across the Americas and Australia.
Plantain Extract loves disturbance and is a common weed of cultivated pastures, cracks in sidewalks, backyard gardens, and any place that experiences regular activity.


Plantain Extract was highly regarded by the Saxons and was considered one of their nine sacred herbs.
This plant, Plantain Extract, has been used by many cultures the world over.
Plantain has a long history of being utilized for a variety of healthful benefits and as an edible food.


Plantain Extract can be valuable externally and is often found in skin care products, especially for its drawing abilities.
This cooling and moistening herb is commonly steeped as tea and combined with other botanicals in herbal infusions.
Plantain Extract is made in small batches at our extract facilities in Eugene, Oregon by our expert team for quality and efficacy.


Delicately aromatic plantain extract can be taken in water or juice, or combined with other extracts including meadowsweet extract, chamomile extract, or catnip extract.
Try a little plantain tincture in some freshly infused happy tummy tea for an additional enhancement.


Plantain Extract contains allantoin as does comfrey.
Plantain Extract is water Soluble.
Plantain Extract is preserved with sodium benzoate and ethanol.


Plantain Extract is a flowering herb that soothes inflamed and irritated skin caused by insect bites, acne, rosacea, and other skin disorders.
Before you start thinking about the fruit that is part of the banana family, it’s important to note that Plantain Extract comes from a different species of this family.


The Plantain Extract used in skin care most often comes from the leaves of Plantago major, which is a low-growing perennial weed found throughout most of North America.
Plantain Extract may also ease itchiness and flaking caused by dandruff.



USES and APPLICATIONS of PLANTAIN EXTRACT:
Plantain Extract is a hydroglycolic extract obtained from the leaves of plantain (Plantago lanceolata).
Plantain Extract is obtained through a controlled extraction process using propylene glycol and water.
Plantain Extract appears as a slightly translucent to opaque liquid, with a possible slight precipitate, and has a characteristic odor.


Plantain Extract is miscible in water and 50% v/v alcohol and is widely used in cosmetic products.
Plantain Extract is used in all types of anti-aging formulations: prevention and regeneration, daytime care products, especially for mature skin, anti-wrinkle treatments, sun care healing, and anti-inflammatory formulations.


Plantain Extract improves collagen production, is antioxidant, anti-inflammatory, and has antimicrobial properties.
Among its active ingredients, Plantain Extract contains 6% mucilage (arabinogalactan, rhamnogalacturonan, glucomannan), pectin, tannins, phenol carboxylic acids (chlorogenic, neochlorogenic, gentisic, protocatechuic), flavonoids (apigenol, luteoloside), mineral salts (silicon, zinc, potassium ), coumarins (esculetin), and iridoid glycosides (asperuloside, aucubin, and catalpol).


Topically, Plantain Extract's use is recommended for conjunctivitis, blepharitis, rhinitis, gingivitis, glossitis, dry eczema, herpes, ichthyosis, psoriasis, and burns.
Plantain Extract is ideal for dry skin or eczema problems.


Plantain Extract is effective against insect bites.
Plantain Extract has long been considered by herbalists to be a useful remedy for cough, wounds, inflamed skin or dermatitis, and insect bites.
Plantain Extract is bruised or crushed leaves have been applied topically to treat insect bites and stings, eczema, and small wounds or cuts.


Plantain Extract is cosmetic grade & for external use only.
Cosmetic Uses of Plantain Extract: antimicrobial agents
Plantain Extractis rich in antioxidants and protects the scalp and hair from environmental stressors and free radical damage.


Plantain Extract stimulates the scalp and hair follicles, thereby promoting better hair growth.
Plantain Extract has a long history of use for inflammation and pain. Plantain Extract is used for soothing and toning the skin.
Plantain Extract's active compound is allantoin, a natural compound with antibacterial and germicidal properties that make it useful as a topical skin healing treatment and an excellent ingredient for face masks.


Some of the benefits of allantoin have long been associated with cell regeneration and skin healing.
Allantoin works in a way similar to an exfoliator.
It removes dead skin cells from the outer layer of the epidermis, softening the skin's keratin and encouraging the growth of new skin cells.


Allantoin is an effective anti-irritant for the skin, calming and soothing sensitive areas.
Plantain Extract has been used to help promote the wound-healing effect, and because it helps with cell regeneration, it has been used to treat skin that has suffered abrasions or burns.


Plantain Extract has also been shown to calm eczema and other skin ailments.
Plantain Extract has the added benefit of promoting additional moisture in the area between cells, which helps keep your skin from moisture evaporating from the skin's surface.


-Dermatological Tips:
For acne sufferers, we recommend use of products containing Plantain Extract both morning and night.
If acne isn’t a concern, use Plantain Extract in the morning to take advantage of its benefits throughout the day.


-MEDICINE uses of Plantain Extract:
Plantain Extract has healing properties of body wounds.
Blood pressure lowering effect.
Plantain Extract is known that it is good for rashes and swelling caused by insect stings.
Plantain Extract is a plant that supports the weakening thanks to its toxin and edema-enhancing properties.


-HAIR CARE uses of Plantain Extract:
*Nourishes hair
*Adds vitality to hair


-SKIN CARE uses of Plantain Extract:
*Passes acne.
*Purifies skin from black spots


-FOOD uses of Plantain Extract:
*Aromatic, adds flavor to food.
*Plantain Extract is used as a flavoring agent in food and beverages.
*Plantain Extract is used as thickener in foods.


-VETERINARY MEDICINE uses of Plantain Extract:
*Plantain Extract is ethical against digestive problems.
Plantain Extract relaxes the stomach and is good for stomach diseases,
Plantain Extract is used in feed and medicine.



FUNCTIONS OF PLANTAIN EXTRACT:
*Skin conditioning : Maintains skin in good condition



WHAT DOES PLANTAIN EXTRACT DO IN A FORMULATION?
*Antimicrobial



IS PLANTAIN EXTRACT GOOD OR BAD FOR YOUR SKIN?
Sourced from the leaves of Plantago major, Plantain Extract offers numerous benefits when it comes to skin care products.
Not only is Plantain Extract a skin-soothing agent, it also has has germicidal and antibacterial properties.



TRY MEN’S SKIN CARE, PLANTAIN EXTRACT::
Benefits of Plantain Extract:
One of the big benefits of Plantain Extract is that it contains Allantoin, which is a powerful skin soothing agent that encourages cell growth.
In face washes, Allantoin is also used as a chemical exfoliant to remove layers of dead skin.
Plantain Extract has wound healing properties, which makes it great as an acne treatment.
Plantain Extract helps to combat acne and it promotes skin regeneration, which reduces the chance of scarring.
Plantain Extract has germicidal and antibacterial properties, which makes it that much more useful in the prevention of acne.
Since Plantain Extract soothes skin, it’s a good treatment for sunburn.



PHYSICAL and CHEMICAL PROPERTIES of PLANTAIN EXTRACT:
Physical State: liquid
Colour: brown



SYNONYMS:
Plantain Extract
Spitzwegerich
Spitzwegerich-Extrakt
Plantago Lanceolata Leaf Extract
Plantago Lanceolata Extract
Plantago lanceolata
P. major
P. psyllium
P. arenaria (P. ramosa) (Spanish or French psyllium seed)
P. ovata (Blond or Indian plantago seed).
Spanish psyllium
French psyllium
blond plantago
Indian plantago
psyllium seed
flea seed
black psyllium

DESCRIPTION:
Plasdone S-630 is a pharmaceutical oral care polymer which has excellent bioadhesion properties and is a tougher, more flexible film former than PVP.
Plasdone S-630 Copovidones a highly compressible powder, making it an excellent tablet binder for direct compression and dry granulation.
Plasdone S-630 is often used with poorly compressible actives to improve tablet breaking force and lower friability.
More recently, these polymers have been used in solid dispersions to increase solubility and thereby increase bioavailability of poorly soluble APIs.



Plasdone S-630 is a 60:40 linear, random copolymer of N-vinyl-2-pyrolidone (PVP) and vinyl acetate.
Plasdone S-630 acts as a tablet binder in denture cleanser tablets.



FEATURES & BENEFITS OF PLASDONE S-630:
Plasdone S-630 Acts as a tablet binder resulting in denture cleanser tablets with high breaking force and low friability
Plasdone S-630 Forms tough, clear, flexible films with high substantivity to skin
Plasdone S-630 is Vegan suitable



Plasdone S-630 copovidone is 60:40 copolymer of n-vinyl-2-pyrrolidone and vinylacetate.
The vinyl acetate in the polymer backbone lowers the polymer’s glass transition temperature compared with polyvinylpyrollidone (PVP) homopolymers and reduces hygroscopicity.
Plasdone S-630 acts as an excellent tablet binder in dry granulation and direct compression tablet process.

Plasdone S-630 is highly compressible and produces more flexible, less brittle films compared to films of PVP homopolymers.
Its lower hygroscopicity improves stability in high humidity.
Plasdone S-630 improves solubility and bioavailability of poorly soluble drug actives through formation of solid dispersions.
Plasdone S-630 copovidone forms tough, clear, flexible films with high substantivity.


Plasdone S-630 acts as a tablet binder resulting in tablets with high breaking force and low friability
Plasdone S-630 is a binder in dry-granulations and direct compression processes.
Plasdone S-630 is used in denture cleanser tablets

Plasdone S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate.
The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monomer reduces glass transition temperature (Tg) and hygroscopicity compared to homopolymers of pyrrolidone (PVP).

Well-known in the industry as a multipurpose excipient, copovidone functions as a binder, solubilizer/solid dispersion carrier and film former in a variety of pharmaceutical formulations
Plasdone S-630 Ultra copovidone is a grade of plasdone s-630 designed to provide better performance in tablet formulations, hot melt extrusion (HME) and continuous processing by offering superior benefits compared to the original plasdone s-630 copovidone.


SAFETY INFORMATION ABOUT PLASDONE S-630:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

Platycodon Root Extract, derived from the root of the Platycodon grandiflorus plant, is renowned for its anti-inflammatory, antioxidant, and expectorant properties.
Platycodon Root Extract is widely recognized in traditional Chinese medicine for its ability to support respiratory health, reduce inflammation, and promote detoxification.
This versatile extract offers both therapeutic and wellness benefits, helping to soothe the throat, improve lung function, and boost immune health.

CAS Number: 84696-21-9
EC Number: 283-323-5

Synonyms: Platycodon Root Extract, Balloon Flower Root Extract, Platycodon grandiflorus Extract, Chinese Bellflower Root Extract, Jie Geng Extract, Platycodon Herbal Extract, Platycodon Phytocomplex, Balloon Flower Bioactive Extract, Balloon Flower Root Active, Platycodon Radix Extract



APPLICATIONS


Platycodon Root Extract is extensively used in traditional respiratory remedies, providing natural support for lung health and helping to clear mucus from the respiratory tract.
Platycodon Root Extract is favored in the formulation of throat-soothing lozenges and syrups, where it helps to reduce cough, soothe throat irritation, and provide anti-inflammatory benefits.
Platycodon Root Extract is utilized in the development of natural expectorants, offering support for individuals with respiratory congestion and promoting the clearance of phlegm.

Platycodon Root Extract is widely used in traditional Chinese medicine formulations for its ability to relieve chronic bronchitis, asthma, and other respiratory conditions by promoting lung health.
Platycodon Root Extract is employed in the production of herbal teas and infusions, offering benefits for soothing a sore throat, reducing cough, and improving breathing.
Platycodon Root Extract is essential in the creation of wellness products designed to support respiratory function, reduce inflammation, and promote overall lung health.

Platycodon Root Extract is utilized in the production of immune-boosting supplements, helping to enhance immune response and protect the body from respiratory infections.
Platycodon Root Extract is a key ingredient in formulations that address seasonal respiratory issues, such as colds, flu, and allergies, providing natural relief for congestion and inflammation.
Platycodon Root Extract is used in the development of anti-inflammatory supplements, where it offers relief from respiratory inflammation and irritation.

Platycodon Root Extract is applied in the formulation of detox teas, helping to support lung health while promoting the elimination of toxins from the body.
Platycodon Root Extract is employed in the creation of herbal remedies for relieving chest congestion, helping to clear the lungs and promote easier breathing.
Platycodon Root Extract is used in traditional herbal formulations to support the respiratory system, addressing chronic coughs and promoting the clearance of mucus.

Platycodon Root Extract is widely utilized in formulations designed for smokers, providing support for lung detoxification and helping to improve respiratory function.
Platycodon Root Extract is a key component in the development of holistic wellness products aimed at supporting respiratory health and reducing the effects of air pollution on lung function.
Platycodon Root Extract is used in the production of herbal tinctures, providing natural support for respiratory issues, especially those related to chronic conditions such as asthma or bronchitis.

Platycodon Root Extract is employed in the formulation of natural remedies for treating respiratory infections, offering benefits for reducing inflammation, clearing mucus, and improving overall lung health.
Platycodon Root Extract is applied in the development of respiratory health capsules, offering immune-boosting and anti-inflammatory properties that support lung function and respiratory wellness.
Platycodon Root Extract is utilized in the creation of wellness beverages designed to soothe the respiratory system and reduce coughing and throat irritation.

Platycodon Root Extract is found in formulations designed to relieve sinus congestion, providing natural support for opening up airways and improving breathing.
Platycodon Root Extract is used in the production of holistic detox products, helping to cleanse the respiratory system and eliminate harmful pollutants and toxins.
Platycodon Root Extract is a key ingredient in wellness teas, where it offers respiratory and immune support while promoting relaxation and relief from congestion.

Platycodon Root Extract is widely utilized in the development of supplements that address chronic respiratory conditions, helping to improve overall lung function and reduce inflammation.
Platycodon Root Extract is a reliable component in the creation of natural treatments for allergy-related respiratory issues, offering support for reducing symptoms such as sneezing, coughing, and nasal congestion.
Platycodon Root Extract is often found in formulations for lung-cleansing therapies, where it aids in the removal of phlegm and enhances breathing comfort.

Platycodon Root Extract is also integrated into formulations designed to treat sore throat and respiratory infections in children, offering safe and natural relief.
Platycodon Root Extract is used in herbal steam treatments for respiratory health, helping to open airways and improve breathing in individuals with sinus congestion.

Platycodon Root Extract is applied in topical formulations to help reduce chest congestion, providing a soothing and warming effect when combined with other natural ingredients.
Platycodon Root Extract is utilized in wellness drinks aimed at boosting lung capacity and promoting clearer breathing, especially for individuals living in polluted environments.

Platycodon Root Extract is commonly used in natural cough syrups for children and adults, providing effective relief from dry or phlegm-producing coughs.
Platycodon Root Extract is found in dietary supplements that support overall respiratory endurance, making it popular among athletes and individuals looking to improve lung health.

Platycodon Root Extract is a key ingredient in respiratory tonics used in traditional herbal therapies to enhance breathing and clear lung congestion.
Platycodon Root Extract is applied in natural remedies for reducing allergic reactions that impact the respiratory system, such as hay fever or allergic rhinitis.

Platycodon Root Extract is employed in air-purifying sprays and inhalants, offering respiratory support and relief from airborne allergens.
Platycodon Root Extract is utilized in combination with other herbs in wellness teas, where it enhances detoxification and supports overall lung function, especially for individuals recovering from respiratory illnesses.



DESCRIPTION


Platycodon Root Extract, derived from the root of the Platycodon grandiflorus plant, is renowned for its anti-inflammatory, antioxidant, and expectorant properties.
Platycodon Root Extract is widely recognized in traditional Chinese medicine for its ability to support respiratory health, reduce inflammation, and promote detoxification.

Platycodon Root Extract offers additional benefits such as soothing throat irritation, reducing coughing, and enhancing overall lung function.
Platycodon Root Extract is often incorporated into formulations designed to support the body's natural respiratory processes, promoting the clearance of phlegm and improving breathing.
Platycodon Root Extract is recognized for its ability to provide relief from chronic respiratory conditions such as bronchitis and asthma, supporting lung health and reducing inflammation.

Platycodon Root Extract is commonly used in both traditional and modern wellness formulations, providing a reliable solution for maintaining respiratory health and immune function.
Platycodon Root Extract is valued for its ability to soothe the throat, calm irritation, and support the body’s natural healing processes, making it a key ingredient in products that aim to promote lung health and reduce inflammation.
Platycodon Root Extract is a versatile ingredient that can be used in a variety of products, including lozenges, syrups, capsules, teas, and wellness beverages.

Platycodon Root Extract is an ideal choice for products targeting respiratory health, immune support, and detoxification, providing natural and effective care for these concerns.
Platycodon Root Extract is known for its compatibility with other lung-supporting and anti-inflammatory ingredients, allowing it to be easily integrated into multi-functional formulations.
Platycodon Root Extract is often chosen for formulations requiring a balance between respiratory relief, immune support, and detoxification, ensuring comprehensive wellness benefits.

Platycodon Root Extract enhances the overall effectiveness of wellness products by providing natural support for respiratory health, throat comfort, and lung detoxification.
Platycodon Root Extract is a reliable ingredient for creating products that offer noticeable improvements in lung function, congestion relief, and respiratory comfort.
Platycodon Root Extract is an essential component in innovative wellness products known for their performance, safety, and ability to support respiratory health and immune function.



PROPERTIES


Chemical Formula: N/A (Natural extract)
Common Name: Platycodon Root Extract (Platycodon grandiflorus Extract)
Molecular Structure:
Appearance: Brown to yellow powder or liquid extract
Density: Approx. 1.00-1.05 g/cm³ (for powder)
Melting Point: N/A (powder form)
Solubility: Soluble in water and ethanol; insoluble in oils
Flash Point: >100°C (for powder)
Reactivity: Stable under normal conditions; no known reactivity issues
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store between 15-25°C in a cool, dry place
Vapor Pressure: Low (for liquid extract)



FIRST AID


Inhalation:
If Platycodon Root Extract is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Wash the affected area with soap and water.
If skin irritation persists, seek medical attention.

Eye Contact:
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
If Platycodon Root Extract is ingested, do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE



Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE) such as gloves and safety goggles if handling large quantities.
Use in a well-ventilated area to avoid inhalation of dust.

Ventilation:
Ensure adequate ventilation when handling large amounts of Platycodon Root Extract to control airborne concentrations below occupational exposure limits.

Avoidance:
Avoid direct contact with eyes and prolonged skin contact.
Do not eat, drink, or smoke while handling Platycodon Root Extract.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Contain spills to prevent further release and minimize exposure.
Absorb with inert material (e.g., sand, vermiculite) and collect for disposal.
Dispose of in accordance with local regulations.

Storage:
Store Platycodon Root Extract in a cool, dry, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid inhalation of dust and direct contact with skin and eyes.
Use explosion-proof equipment in areas where dust or vapors may be present.

Pluriol A 500 E is a Pluriol A 500 E with an average molecular weight of 120.14698.
Pluriol A 500 E is a clear, odorless almost colorless, viscous liquid.
Pluriol A 500 E is heat stable and hygroscopic, and has a low vapor pressure.

CAS Number: 9004-74-4
Molecular Weight: 120.14698
EC Number: 215-801-2

Pluriol A 500 E is a polymer which is hydrolyzed by ethylene oxide.
Pluriol A 500 E has no toxicity and irritation.
Pluriol A 500 E is widely used in various pharmaceutical preparations.

The toxicity of low molecular weight Pluriol A 500 E is relatively large.
In general, the toxicity of diols is very low.
Topical application of Pluriol A 500 E, especially mucosal drug, can cause irritant pain.

In topical lotion, Pluriol A 500 E can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Pluriol A 500 E can occur in large doses of oral administration.
In injection, the maximum Pluriol A 500 E 300 concentration is about 30% (V/V).

Pluriol A 500 E could occur when the concentration is more than 40% (V/V).
Pluriol A 500 E grades are used as raw materials in the production of comb polymers applied as dispersants and plasticizers for concrete.
The low diol content of Pluriol A 500 E prevents undesirable side reactions.

Pluriol A 500 E is also used to change the chain length of polyurethanes.
Pluriol A 500 E is a medication that is used in the management and treatment of constipation.
Pluriol A 500 E is in the laxative class of drugs.

This activity describes the indications, action, and contraindications for Pluriol A 500 E as a valuable agent in the treatment of constipation.
Pluriol A 500 E, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments, and suppository base, and tablet and capsule lubricant.
Pluriol A 500 E has low toxicity with systemic absorption less than 0.5%.

Pluriol A 500 Es are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.

The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific Pluriol A 500 E product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific Pluriol A 500 Es.

Pluriol A 500 Es with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.

Pluriol A 500 E is also known as polyoxirane (PEO).
Pluriol A 500 E is a linear polyether obtained by ring opening polymerization of ethylene oxide.
Pluriol A 500 E contact lens liquid.

The viscosity of Pluriol A 500 E solution is sensitive to the shear rate and it is not easy for bacteria to grow on Pluriol A 500 E.
The condensation polymer of ethylene oxide and water.
Pluriol A 500 E is a cream matrix for preparing water-soluble drugs.

Pluriol A 500 E can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
Drug sustained-release and immobilized enzyme carrier.
The Pluriol A 500 E solution is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.

Pluriol A 500 E surface modification of medical polymer materials.
The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing Pluriol A 500 E on the surface of medical polymers.

Pluriol A 500 E, the process of attaching PEG molecules to drugs or drug carriers, can alter the pharmacokinetics of drugs, extending their circulation time in the body and potentially reducing immunogenicity.
Pluriol A 500 E can have various derivatives, such as those modified with different functional groups or chain lengths.
These derivatives can exhibit specific properties suited to particular applications.

Pluriol A 500 E can make the membrane of the alkanol contraceptive pill.
Pluriol A 500 E can make hydrophilic anticoagulant polyurethane.
Pluriol A 500 E 4000 is an osmotic laxative.

Pluriol A 500 E can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Pluriol A 500 E nontoxic and gelatinous nature can be used as a component of denture fixer.

Pluriol A 500 E are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation.
Pluriol A 500 E absorbs water from the solution, so it is also used to concentrate the solution.

Melting point: 64-66 °C
Boiling point: >250°C
Density: 1.27 g/mL at 25 °C
vapor density: >1 (vs air)
vapor pressure: refractive index: n20/D 1.469
Flash point: 270 °C
storage temp.: 2-8°C
solubility: H2O: 50 mg/mL, clear, colorless
form: waxy solid
color: White to very pale yellow
Specific Gravity: 1.128
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Merck: 14,7568
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃

Pluriol A 500 E is soluble in water, acetone, ethanol, ethyl acetate and toluene.
The two primary hydroxyl groups of Pluriol A 500 E undergo typical alcohol reactions to form monoesters, diesters, ethers, acetals and amines.
Pluriol A 500 E fatty esters are useful plasticizers for vinyl resins and other materials.

Polyesters of maleic acid are used commercially as copolymers with Vinyl monomers, styrene and vinyl esters.
The resins are used for impregnation and molding.
Pluriol A 500 Es are used as lubricants for the air bags in pneumatic tires.

Pluriol A 500 E is used to improve the solubility of poorly water-soluble drugs, enhancing their bioavailability and effectiveness.
Pluriol A 500 E's incorporated into drug delivery systems to modify the release profile of drugs, enabling controlled and sustained drug delivery.
Pluriol A 500 E provides moisturization and smoothness to the skin, making it a popular ingredient in lotions, creams, and moisturizers.

Pluriol A 500 E's used as an emulsifier in cosmetic formulations, helping blend water and oil-based ingredients.
Pluriol A 500 E is sometimes employed to functionalize nanoparticles and improve their biocompatibility and stability.
Pluriol A 500 E can also help nanoparticles evade the immune system, making them more suitable for medical applications like targeted drug delivery.

Suitable as paper softeners because of their humectant properties and low vapor pressure.
Pluriol A 500 E also used as plasticizers in the manufacture of uncoated cellophane and cellulose sponges.
Pluriol A 500 Es and their fatty acid derivatives are used for such varied purposes as emulsification, washing, lubrication, static prevention, pigment dispersion and softening in textiles and leather applications.

Pluriol A 500 E u sed in the production of steam set printing inks.
When used in combination with ethylene and diethylene glycols, they control the amount of moisture pickup in the setting of inks.

Uses
Pluriol A 500 E is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Pluriol A 500 E is soluble in water (mw 1,000) and many organic solvents.
Pluriol A 500 E (PEG) is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments.

Pluriol A 500 E are quite humectant up to a molecular weight of 500. Beyond this weight, their water uptake diminishes.
Pluriol A 500 E is used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of Pluriol A 500 E were used for drug delivery.

Pluriol A 500 E molecules of approximately 2000 monomers.
Pluriol A 500 E is used in various industrial applications due to its solubility and non-reactive nature:
Pluriol A 500 E can be used as a solvent or diluent in adhesive formulations.

Pluriol A 500 E can contribute to the properties of coatings, such as improved flow and leveling.
In laboratory settings, Pluriol A 500 E might be used as a component in various solutions or as a stabilizing agent.
Pluriol A 500 E nanoparticles are utilized for targeted drug delivery, enhancing drug accumulation in specific tissues while minimizing side effects.

Pluriol A 500 E is used in textile dyeing and finishing processes to enhance dye penetration and improve fabric properties.
Pluriol A 500 E and other PEG derivatives are used as stabilizers and excipients in a wide range of products:
Pluriol A 500 E derivatives are approved for use as food additives and stabilizers in certain food and beverage products.

Pluriol A 500 E derivatives can serve as emulsifiers, thickeners, and stabilizers in cosmetics, skincare products, and toiletries.
Pluriol A 500 E can be used in pesticide formulations to improve the dispersion of active ingredients and enhance their effectiveness.
Pluriol A 500 E can be added to paint formulations to improve the stability of pigments, enhance paint flow, and reduce defects.

Pluriol A 500 E can be present in household cleaners and disinfectants, aiding in solubilizing active ingredients and improving cleaning performance.
Pluriol A 500 E's used in some personal hygiene products like soaps and hand sanitizers for its emulsifying and cleansing properties.
Pluriol A 500 E can be used in industrial degreasing formulations due to its ability to solubilize oils and greases.

Pluriol A 500 E is used in textile dyeing and printing processes to improve dye dispersion and color uptake.
Pluriol A 500 E is used in various applications from industrial chemistry to biological chemistry.
Recent research has shown Pluriol A 500 E aintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.

Pluriol A 500 E is industrially produced as a lubricating substance for various surfaces to reduce friction.
Pluriol A 500 E is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.

Safety
Pluriol A 500 Es are widely used in a variety of pharmaceutical formulations.
Generally, they are regarded as nontoxic and nonirritant materials.
Adverse reactions to Pluriol A 500 Es have been reported, the greatest toxicity being with glycols of low molecular weight.

However, the toxicity of glycols is relatively low.
Pluriol A 500 Es administered topically may cause stinging, especially when applied to mucous membranes.
Hypersensitivity reactions to Pluriol A 500 Es applied topically have also been reported, including urticaria and delayed allergic reactions.

The most serious adverse effects associated with Pluriol A 500 Es are hyperosmolarity, metabolic acidosis, and renal failure following the topical use of Pluriol A 500 Es in burn patients.
Topical preparations containing Pluriol A 500 Es should therefore be used cautiously in patients with renal failure, extensive burns, or open wounds.
Oral administration of large quantities of Pluriol A 500 Es can have a laxative effect.

Therapeutically, up to 4 L of an aqueous mixture of electrolytes and high-molecular-weight Pluriol A 500 E is consumed by patients undergoing bowel cleansing.
Liquid Pluriol A 500 Es may be absorbed when taken orally, but the higher-molecular-weight Pluriol A 500 Es are not significantly absorbed from the gastrointestinal tract. Absorbed Pluriol A 500 E is excreted largely unchanged in the urine, although Pluriol A 500 Es of low molecular weight may be partially metabolized.

Synonyms
25322-68-3
POLYETHYLENEGLYCOL 6000
Pluriol A 500 E monomethylether
methoxyPluriol A 500 E.

PLURONIC FT L 61 PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. Because the lengths of the polymer blocks can be customized, many different PLURONIC FT L 61s exist that have slightly different properties. For the generic term PLURONIC FT L 61, these copolymers are commonly named with the letter P (for PLURONIC FT L 61) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = PLURONIC FT L 61 with a polyoxypropylene molecular mass of 4000 g/mo} PLURONIC FT L 61 and a 70% polyoxyethylene content). For the PLURONIC FT L 61 and Synperonic tradenames, coding of these copolymers starts with a letter to define PLURONIC FT L 61’s physical form at room temperature (L = liquid, P = paste, F = flake (solid)) followed by two or three digits, The first digit (two digits in a three-digit number) in the numerical designation, multiplied by 300, indicates the approximate molecular weight of the hydrophobe; and the last digit x 10 gives the percentage polyoxyethylene content (e.g., L61 indicates a polyoxypropylene molecular mass of 1800 g/mol and a 10% polyoxyethylene content). In the example given, PLURONIC FT L 61 181 (P181) = PLURONIC FT L 61 L61 and Synperonic PE/L 61. Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting. The PLURONIC FT L 61s have been shown to incorporate into cellular membranes affecting the microviscosity of the membranes. The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle. ). PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. PLURONIC FT L 61s are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide (PO) (OEx–POy–OEx). PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61s have been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells. PLURONIC FT L 61s have also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. The PLURONIC FT L 61s have also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles. An important characteristic of PLURONIC FT L 61 solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of PLURONIC FT L 61s are PLURONIC FT L 61s and poloxamines are also known as macromolecules, respectively. PLURONIC FT L 61s are a family of more than 50 different amphiphilic nonionic block polymers of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO), covering a range of liquids, pastes and solids. PLURONIC FT L 61s consist of a central polyoxypropylene (POP) molecule, which is flanked on both sides by two hydrophilic chains of polyoxyethylene (POE). A slightly different structure is exhibited by the poloxamines, which are tetrafunctional block copolymers with four POE–POP blocks joined together by a central ethylene diamine bridgeliquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in PLURONIC FT L 61s depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. Assessment of PLURONIC FT L 61s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, and PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, and PLURONIC FT L 61 182 Dibenzoate as Used in Cosmetics. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61s and poloxamines are also known as macromolecules, respectively. PLURONIC FT L 61s are a family of more than 50 different amphiphilic nonionic block polymers of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO), covering a range of liquids, pastes and solids. PLURONIC FT L 61s consist of a central polyoxypropylene (POP) molecule, which is flanked on both sides by two hydrophilic chains of polyoxyethylene (POE). A slightly different structure is exhibited by the poloxamines, which are tetrafunctional block copolymers with four POE–POP blocks joined together by a central ethylene diamine bridgeliquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in PLURONIC FT L 61s depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. Different phase diagrams characterizing all these transitions have been constructed for most PLURONIC FT L 61s using a great variety of experimental techniques (e.g. SAXS, PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. They also clean the skin and hair by helping water to mix with oil and dirt so that they can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance.Differential scanning calorimetry, viscosity measurements, light scattering). PLURONIC FT L 61s are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules whose self-assembling properties display a wide range of phase behavior. This ability to form micelles and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC). PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘PLURONIC FT L 61’ was coined by the inventor, Irving Schmolka, who received the patent for PLURONIC FT L 61s in 1973. PLURONIC FT L 61s are also known by their trade name PLURONIC FT L 61s. Concentrated PLURONIC FT L 61 solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial PLURONIC FT L 61 407 have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery. Solutions of PLURONIC FT L 61 407 (∼25%) are viscous liquids below 25 °C; at body temperature PLURONIC FT L 61s form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of PLURONIC FT L 61 407 in cell delivery systems. Introduction of the carbonate linkage between PLURONIC FT L 61 ‘blocks’ and linking of PLURONIC FT L 61s into structures of a higher molecular mass118 PLURONIC FT L 61 were attempted to overcome these disadvantages. PLURONIC FT L 61 is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO). PLURONIC FT L 61s and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders. Another important property of PLURONIC FT L 61s is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures. Certain PLURONIC FT L 61s such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression. Certain PLURONIC FT L 61s, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa. An important characteristic of PLURONIC FT L 61 solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of PLURONIC FT L 61s are liquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in these systems depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. Different phase diagrams characterizing all these transitions have been constructed for most PLURONIC FT L 61s using a great variety of experimental techniques. In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. PLURONIC FT L 61s also clean the skin and hair by helping water to mix with oil and dirt so that PLURONIC FT L 61s can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. PLURONIC FT L 61s are polyoxyethlyene, polyoxypropylene block polymers. The impurities of commercial grade PLURONIC FT L 61 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and residual ethylene oxide and propylene oxide. Most PLURONIC FT L 61s function in cosmetics as surfactants, emulsifying agents, cleansing agents, and/or solubilizing agents, and are used in 141 cosmetic products at concentrations from 0.005% to 20%. PLURONIC FT L 61s injected intravenously in animals are rapidly excreted in the urine, with some accumulation in lung, liver, brain, and kidney tissue. In humans, the plasma concentration of PLURONIC FT L 61 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘PLURONIC FT L 61’ was coined by the inventor, Irving Schmolka, who received the patent for PLURONIC FT L 61s in 1973. PLURONIC FT L 61s are also known by their trade name PLURONIC FT L 61s. Concentrated PLURONIC FT L 61 solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial PLURONIC FT L 61 407 have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery. Solutions of PLURONIC FT L 61 407 (∼25%) are viscous liquids below 25 °C; at body temperature PLURONIC FT L 61s form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of PLURONIC FT L 61 407 in cell delivery systems. Introduction of the carbonate linkage between PLURONIC FT L 61 ‘blocks’ and linking of PLURONIC FT L 61s into structures of a higher molecular mass118 PLURONIC FT L 61 were attempted to overcome these disadvantages. PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.PLURONIC FT L 61 is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO). Formulation and characterization of PLURONIC FT L 61 thermoreversible gel containing polymeric microparticles and hyaluronic acid. PLURONIC FT L 61s are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. PLURONIC FT L 61 is composed of triblock copolymers of polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61 as a nonionic surfactant, the synthetic polymer has been previously used in drug delivery and medical imaging applications PLURONIC FT L 61 sol-gel reversible hydrogels have attracted the attention for practical biomedical and pharmaceutical applications because of constituents solubility, biocompatibility with biological systems and easy administration of pharmaceutical formulations. The pharmaceutical and biomedical fields covered by the use of PLURONIC FT L 61s including solubilization of hydrophobic drugs, controlled release, biomacromolecule delivery (e.g., proteins and genes) and tissue engineering. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. PLURONIC FT L 61s also clean the skin and hair by helping water to mix with oil and dirt so that PLURONIC FT L 61s can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. PLURONIC FT L 61 with its synonym as polyethylene-propylene glycol copolymer and trade names as Supronic, PLURONIC FT L 61 or Tetronic have been introduced in 1950 as a non-ionic triblock copolymer. Assessment of PLURONIC FT L 61s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, and PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, and PLURONIC FT L 61 182 Dibenzoate as Used in Cosmetics. They were since then very famously used in diverse pharmaceutical applications. Chemically PLURONIC FT L 61 is α-Hydro-ω-hydroxypoly (oxyethylene)a poly (oxypropylene)b poly (oxyethylene)a block copolymer and they consisted of two hydrophilic chains of ethylene oxide chains (PEO) that sandwiched one hydrophobic propylene oxide chain (PPO) giving a chemical formula HO(C2H4O)a(C3H6O)b(C2H4O)aH where a and b have the values as shown in the Table 1. The varying length of polymer blocks giving rise to different polymers identified as PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 and PLURONIC FT L 61 407 showing a slight difference in their properties. Most applications involve the use of PLURONIC FT L 61 P407 and include delivery of protein/peptide drugs [25], such as insulin [26], interleukin-2 [27], epidermal growth factor [28], bone morphogenic protein [29], fibroblastic growth factor, and endothelial cell growth factor [30]. Surfactants play an important role in stabilizing proteins in liquid formulations against aggregate/particle formation during processing, handling, storage, and transportation. Only 3 surfactants are currently used in marketed therapeutic protein formulations: polysorbate 20, polysorbate 80, and PLURONIC FT L 61 188. While polysorbates are the most widely used surfactants, their intrinsic oxidative and hydrolytic degradation issues highlights the importance of alternative surfactants such as PLURONIC FT L 61 188. Here, we compare polysorbates and PLURONIC FT L 61 188 with regards to their stabilizing properties under various stress and storage conditions for several monoclonal antibody formulations. Our data shows that PLURONIC FT L 61 188 can provide suitable protection of monoclonal antibodies against interfacial stress in liquid formulations in vials. However, visible protein-polydimethylsiloxane (PDMS; silicone oil) particles were observed in vials after long-term storage at 2-8°C for some protein formulations using PLURONIC FT L 61 188, which were not observed in polysorbate formulations. The occurrence of these protein-PDMS particles in PLURONIC FT L 61 188 formulations is a protein-specific phenomenon that may correlate with protein physico-chemical properties. In this study, the primary source of the PDMS in particles found in vials was considered to be from the primary packaging stoppers used. Our findings highlight benefits, but also risks associated with using PLURONIC FT L 61 188 in liquid biotherapeutic formulations. PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.

Nonionic surfactants, which are favored in topical formulations because they have less potential for skin irritancy compared with ionic surfactants, and certain solvents alter the emulsions coating hair/wool, thereby allowing more drug to reach the skin surface.
Pluronic PE 6400 is postulated that the mechanism by which skin penetration enhancers increase drug transport across the skin involves increasing the fluidity and/or the hydration of the polar head groups of the lipid bilayers.

CAS: 68213-23-0
MF: C12H25O(CH2CH2O)9H
MW: 0
EINECS: 500-201-8

General rule that the solubility of Pluronic PE types in water increases in step with the proportion of polyethylene glycol they contain.
If two products contain the same mass fraction of Pluronic PE 6400, the molar mass of the polypropylene glycol block is the determining factor, and the one with the lower molar mass will be the more soluble.
Pluronic PE 6400 is a 100% active, low-foaming, nonionic surfactant.
Pluronic PE 6400 is block copolymers in which the central polypropylene glycol group is flanked by two polyethylene glycol groups.
Pluronic PE 6400 perform well as dispersing agents and emulsifiers.

Pluronic PE 6400 supplied in liquid, paste, solid, or powder form, depending on their degree of ethoxylation.
Pluronic PE 6400 can be employed in a very wide variety of applicationssuch asdefoamers in sugar refining, wetting agents in agro chemical formulations, and as lubricants in metalworking fluids.
Pluronic PE 6400 has strong leveling, slow-dyeing, permeability and diffusibility for various dyes.
Pluronic PE 6400 has the ability to assist in scouring and can be used with various surfactants and dyes.
Pluronic PE 6400 is resistant to acid, alkali, hard water, heat and heavy metal salts.

Physical form(25 °C): Liquid
Viscosity (23 ℃, Brookfield)[mPa•s]: approx. 1000
pH (5% in water ): 7
Cloud point (water) [° C]: 60
Surface tension(DIN 53914, 1 g/l, 23 °C)[mN/m]: approx. 41
Density (g/cm3): approx. 1.05

Applications:
Pluronic PE 6400 is leveling agent and retarding agent for printing and dyeing industry, which can improve scouring and color fastness,
Formulate detergent for metal processing,
Used as lubricant emulsifier in glass fiber industry,
Used as a seed soaking penetrant in agriculture to increase the germination rate of seeds.
Used as an emulsifier in other industries.
Pluronic PE 6400 has the highest detergency of all the products in the Pluronic PE range, and it is low-foaming.
Pluronic PE 6400 performs particularly well in applications that involve intensive mechanical action, i.e. in dishwashers and industrial bottle-washing machines.
Pluronic PE 6400 can also be used in dairy cleaners.
Other areas of application include cutting and grinding fluids for metal, where Pluronic PE 6400 acts as a lubricant and coolant.

Pluronic PE 6400 content and the molar mass of the central polypropylene glycol block of surfactants of this type can be varied within wide limits, and the result is that they are exceptionally versatile.
Pluronic PE 6400 types can be tailored to boost their wetting, dispersing or emulsifying properties as the situation requires.
Pluronic PE 6400 can be used to reduce foam or eliminate it altogether, and they can be used as solubilizers and thickeners.
Pluronic PE 6400 ability to act as impregnating agents, humectants, plasticizers and lubricants can be exploited in a variety of situations.
Pluronic PE 6400 can be used to adjust the viscosity of other liquids, to make tacky substances more coherent, and to disperse suspended solids.
Pluronic PE 6400 can also be employed as heat transfer fluids and hydraulic fluids in some applications.
Pluronic PE 6400 can be used in detergents and cleaners in the dairy, brewery and soft drinks sectors, for instance, in cleaners that are sprayed onto metal components to remove shavings and swarf, in the rubber and plastics industries, and in other branches of industry.

Synonyms
Alcohols, C12-18, ethoxylated
68213-23-0
(C12-C18) Alkyl alcohol ethoxylate
500-201-8
C12-18 Alkyl alcohol ethoxylate
DTXSID5041934
EC 500-201-8
Ethoxylated C12-18 alcohols
Poly(oxy-1,2-ethanediyl), alpha-(C12-C18) alkyl-omega-hydroxy-

Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word poloxamer was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.Poloxamers are also known by the trade names Synperonics,Pluronic,and Kolliphor.Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. For the generic term poloxamer, these copolymers are commonly named with the letter P (for poloxamer) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = poloxamer with a polyoxypropylene molecular mass of 4000 g/mo} and a 70% polyoxyethylene content). For the Pluronic and Synperonic tradenames, coding of these copolymers starts with a letter to define its physical form at room temperature (L = liquid, P = paste, F = flake (solid)) followed by two or three digits, The first digit (two digits in a three-digit number) in the numerical designation, multiplied by 300, indicates the approximate molecular weight of the hydrophobe; and the last digit x 10 gives the percentage polyoxyethylene content (e.g., L61 indicates a polyoxypropylene molecular mass of 1800 g/mol and a 10% polyoxyethylene content). In the example given, poloxamer 181 (P181) = Pluronic L61 and Synperonic PE/L 61.An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in these systems depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio).The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. Different phase diagrams characterizing all these transitions have been constructed for most poloxamers using a great variety of experimental techniques (e.g. SAXS, Differential scanning calorimetry, viscosity measurements, light scattering).In bioprocess applications, poloxamers are used in cell culture media for their cell cushioning effects because their addition leads to less stressful shear conditions for cells in reactors.In materials science, the poloxamer P123 has recently been used in the synthesis of mesoporous materials, including SBA-15.When mixed with water, concentrated solutions of poloxamers can form hydrogels. These gels can be extruded easily, acting as a carrier for other particles, and used for robocasting.Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting. The poloxamers have been shown to incorporate into cellular membranes affecting the microviscosity of the membranes. The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle.Poloxamers have been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells. Poloxamers have also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin.The poloxamers have also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles.Certain poloxamers such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression. Certain poloxamers, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa.Wang et al. reported that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells. Moreover, toxicity correlated with the sonolytic degradation of the polymers.Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units.This particular compound is also known by the BASF trade name Pluronic F-127 or by the Croda trade name Synperonic PE/F 127.Most of the common uses of poloxamer 407 are related to its surfactant properties. For example, it is widely used in cosmetics for dissolving oily ingredients in water. It can also be found in multi-purpose contact lens cleaning solutions, where its purpose there is to help remove lipid films from the lens. It can also be found in some mouthwashes. There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically.Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties.In a 30% solution by weight, poloxamer 407 forms a gel solid at room temperature but liquifies when chilled to 4 °C (39 °F). This allows poloxamer 407 to serve as a removable support material, particularly for creating hollow channels or cavities inside hydrogels.In this role, it is often referred to as a "sacrificial ink" or a "fugitive ink".They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.Wang et al. reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can become highly toxic to cultured cells. The toxicity correlated with the sonolytic degradation of the polymers.Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘poloxamer’ was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973. Poloxamers are also known by their trade name Pluronics” .Concentrated poloxamer solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial poloxamer 407 (Pluronic® F127) have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery.Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure. Poloxamer 407 (Pluronic® F127, PEO99–PPO67–PEO99) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25°C at a concentration of 20 wt%.Like PNIPAAm polymers, much effort has been made to synthesize chemically crosslinkable poloxamers to equip them with enhanced mechanical properties.Solutions of poloxamer 407 (∼25%) are viscous liquids below 25 °C; at body temperature they form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of poloxamer 407 in cell delivery systems. Introduction of the carbonate linkage between poloxamer ‘blocks’ and linking of poloxamers into structures of a higher molecular mass118 were attempted to overcome these disadvantages. However, only more sophisticated synthetic procedures offering graft copolymers hold promise for the application as injectable cell carriers.While the physically crosslinked gels display a compressive modulus of 142.5 ± 29.7 KPa, radically crosslinked gels using the methacrylated poloxamer and ammonium persulfate (APS) as a thermal initiator are three times stiffer, displaying a compressive modulus of 415 ± 45.7 KPa.Lysozyme has been utilized as a model protein to test the protein release profile of the diacrylated poloxamer hydrogels with higher mechanical properties. These poloxamers instantaneously formed a semi–solidified physical gel when the temperature was increased above the LCST. Then these poloxamers underwent photocrosslinking initiated by pre–mixed (4–Benzoylbenzyl)trimethylammonium chloride with UV exposure. Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32.It is more commonly called Pluronic® (BASF). Since the middle block is hydrophobic and the two end blocks are hydrophilic, the poloxamer behaves as polymer surfactant. It is used as nonionic polymer surfactant. They can function as antifoaming agents, wetting agents, dispersants, thickeners, and emulsifiers.Poloxamers are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios.Another important property of Poloxamers is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures. It is for this reason that the Poloxamer 407 phase transitions and the effect of hydroxypropyl β-cyclodextrin (HP β–CD) on them were studied using acoustic spectroscopy with purpose of verifying the relevance of this method in the pharmaceutical field .These works introduced here are just a small fraction of a large number of studies on poloxamers. One of the reasons why poloxamers have been investigated by SANS is its variety of phase behavior, applications, particularly to bioengineering field. Since there are many variations in poloxamer with different numbers of x, y, and z in spite of its simple structure , there still remain a large number of studies on poloxamer with SANS.As the first step, the hydrodynamic diameter of the micelles of Poloxamer 407 in the concentration range of 3–25% (w/v) was investigated by measuring the attenuation and propagation velocity of ultrasound at different temperatures.Then the effect of the addition of HP β-CD on the Poloxamer 407 water systems was monitored by adding different amounts [5–20% (w/v)] of HP β–CD, which is widely used in oral and parenteral pharmaceutical dosage forms since it increases the stability and solubility or poorly water-soluble drugs through the formation of inclusion complexes. Previous studies had demonstrated that the addition of different glycols and polyalcohols, as well as the addition of HP β–CD, influenced both the gelation and micellization temperature of Poloxamer 407, outlining a shift of this parameter towards higher values. In this case, acoustic spectroscopy allowed a better characterization of the microstructure and behaviour of these systems at increasing temperatures.The positive thermoresponsive materials turn to gel above the upper critical solution temperature (USCT), which depends on the polymer structure, such as poloxamer, hydroxypropylcellulose, or methylcellulose.The value of modulus G′ for Poloxamer 407 decreases during micellization until it reaches a plateau. This trend is more evident in concentrated systems, but is practically not detectable for the dilute ones. For the 17.5% and 20% samples, it is also possible to identify a slight inflexion after the plateau, which may be identified with the sol/gel transition since the corresponding values of the temperature are in agreement with those determined rheologically and by thermal analysis.The poloxamers, also known by the trademark Pluronic, Synperonic and Tetronic, were initially introduced between 1950 and have presented several pharmaceutical applications, as well as, excellent compatibility with other compounds.Studies showed some of the poloxamer’s characteristics, especially thermoresponsiveness, high capacity to solubilize drugs, good drug release characteristics, and absence of toxicity in mucosal membranes, and thus widely recognized in the pharmaceutical area as a safe material.Poloxamers are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide.The poloxamer 407 or Pluronic F127 has particularly interest because of the thermoreversible properties, and can be useful in the optimization of drug delivery systems, and employed in many formulations like intravenous preparations, topical, ophthalmic, nasal, vaginal, and rectal, with no irritation or skin sensitivity.Poloxamer 407 aqueous solutions have the property of being a thermoresponsive system, which leads to a sol–gel transition due to temperature increase.The advantages of poloxamers in liquid pharmaceutical forms are especially because that they allow a comfortable release at the action site, gelling at the site and may have modified release.Aqueous solutions of Poloxamer or Pluronic undergo sol-to-gel transition as the temperature increases. However, the implanted gel of Poloxamer is quickly eroded and does not persist for more than a few days at most. To improve the system, end-group modified Poloxamers, and multiblock co-polymers consisting of Poloxamer and biodegradable polymers have been developed. In addition, random multiblock copolymers consisting of PEG, PPG, and a biodegradable polymer were reported.Even though modification of the hydroxyl end groups of Poloxamer by oligolactides (LA6) and oligocaprolactones (CL6) increases hydrophobicity of the polymer, the sol-to-gel transition temperature and critical gel concentration increased, compared with the unmodified Poloxamer.Poloxamer aqueous solution is driven by the unimer-to-micelle transition, followed by packing of the micelles. The oligolactide and oligocaprolactone partition into the PPG micelle core and disturb the integrity and density of the original micelles of the unmodified Poloxamer.Poloxamer. Thus, the micelle packing mechanism for the sol-to-gel transition is interfered with. Poloxamer (F127) was modified by oligolactide (LA8 or LA18), and was then reacted with succinic anhydrides to prepare a carboxylic acid end-capped Poloxamer. The polymer showed sol-gel transition in a pH/temperature dependent manner. The ionization of carboxylic acid and the decrease in solubility of PEG at high pH were suggested to explain the phase behavior.34,35 L-dihydroxyphenyalanine end-capped Poloxamer (F127) showed an increase in bioadhesion between the polymer and bovine mucin, an increase in the sol-to-gel transition temperature.Multiblock copolymers were prepared to improve gel properties such as gel duration and biodegradation. Poloxamers (F127) were coupled by hexa-methylene diisocyanate to prepare multiblock Poloxamer.37 The drug release rate from the multiblock Poloxamer hydrogel was slower than from the unmodified Poloxamer hydrogel. PEG/PPG alternating multiblock copolymers showing thermogelling were reported.Poloxamer was coupled by terephthalic anhydride to introduce the biodegradability as well as pH sensitivity.35 Poloxamer was also coupled by disulfide to show glutathione sensitive degradation and drug release.44 In addition, Poloxamer was end capped by l-oligolactide or d-oligolactide, then coupled to prepare the multiblock Poloxamer containing PLA. By mixing the l-isomer and d-isomer containing multiblock Poloxamer, a stereocomplex showing thermal gelation was prepared.Pluronics, also known as poloxamers, are a class of synthetic block copolymers which consist of hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(propylene oxide) (PPO), arranged in an A-B-A triblock structure, thus giving PEO-PPO-PEO.Poloxamer 407 in conjuction with HPMC has been used for rectal delivery of quinine in children.Use of poloxamer 188 as a membrane sealant on in vitro studies of cardiac myocytes showed signs of possible prevention of cardiomyopathy and heart failure in muscular dystrophy.A combination of poloxamer 407, poloxamer 188 and carbopol was utilized as an ophthalmic delivery system for puerarin, thus providing an alternative for longer-lasting drug availability to the precorneal area.Poloxamer 407 has also shown prolonged duration of the painkiller, lidocaine, at the injection site as well as sustained drug release and increased therapeutic efficacy.In the absence of interfering compounds, polymers of the poloxamer type can sometimes be determined by reversed-phase HPLC with methanol, but the most common separation technique is SEC.There are many commercialized copolymers, such as Pluronics, Poloxamers, and Tetronics, which are comprised of PEO–PPO sequences. Poloxamers, nonionic polymers polyoxyethylene–polyoxypropylene–polyoxyethylene (PEOn–PPOn–PEOn), are commonly used in pharmaceutical application in drug delivery.This review article focuses on thermoresponsive hydrogels consisting of poloxamers which are of high interest for biomedical application especially in drug delivery for ophthalmic, injectable, transdermal, and vaginal administration. These hydrogels remain fluid at room temperature but become more viscous gel once they are exposed to body temperature. In this way, the gelling system remains at the topical level for a long time and the drug release is controlled and prolonged. Poloxamers are synthetic triblock copolymers of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), also commercially known as Pluronics®, Synperonics® or Lutrol®. The different poloxamers cover a range of liquids, pastes, and solids, with molecular weights and ethylene oxide–propylene oxide weight ratios varying from 1100 to 14,000 and 1:9 to 8:2, respectively. Concentrated aqueous solutions of poloxamers form thermoreversible gels. In recent years this type of gel has arouse interest for tissue engineering. Finally, the use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC). This property is exploited for drug delivery and different therapeutic applications.“Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘poloxamer’ was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973. Poloxamers are also known by their trade name Pluronics”.Concentrated poloxamer solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial poloxamer 407 (Pluronic® F127) have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery.6 Pluronic® F127 is generally accepted as safe, although in animal studies injection of doses exceeding 27.5 mg kg− 1116,117 caused serious increases in blood cholesterol and triglycerides.Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure. Poloxamer 407 (Pluronic® F127, PEO99–PPO67–PEO99) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25°C at a concentration of 20 wt%. However, its applications are greatly limited by its poor mechanical properties resulting from the purely physical crosslinking. These gels are characterized by low viscosity and very high permeabilities. Moreover, while they instantaneously gel upon increasing temperature above LCST in the body, they lose their structural integrity when mixed with aqueous solutions, which makes them unfit for drug delivery purposes. Like PNIPAAm polymers, much effort has been made to synthesize chemically crosslinkable poloxamers to equip them with enhanced mechanical properties. However, due to their chemical structure, reactive groups are only available at chain ends, therefore, chemically cross–linkable groups can only be used to end–cap the triblock chain. There are two main types of crosslinkable end–capping groups: methacrylate/acrylate and ethoxylsilane. Methacrylates/acrylates can be coupled to the polymer by reacting methacryloyl chloride/acryloyl chloride with the hydroxyl groups on both ends. Similarly, (3–isocyanato–propyl)triethoxysilane can be employed to react with the hydroxyl groups under catalysis of 2–ethyl–hexanoate to introduce ethoxysilane end–capping groups. While the physically crosslinked gels display a compressive modulus of 142.5 ± 29.7 KPa, radically crosslinked gels using the methacrylated poloxamer and ammonium persulfate (APS) as a thermal initiator are three times stiffer, displaying a compressive modulus of 415 ± 45.7 KPa. Although the exthoxysilane causes gradual chemical crosslinking (same mechanism as crosslinking of trimethoxysilane–grafted PNIPAAm–based hydrogels), their crosslinking resulted in a much higher compressive modulus: ~2600 KPa after 17 days. Lysozyme has been utilized as a model protein to test the protein release profile of the diacrylated poloxamer hydrogels with higher mechanical properties. These poloxamers instantaneously formed a semi–solidified physical gel when the temperature was increased above the LCST. Then these poloxamers underwent photocrosslinking initiated by pre–mixed (4–Benzoylbenzyl)trimethylammonium chloride with UV exposure. With photocrosslinking, the gels maintained their structural integrity up to one month. While burst release of 50–70 wt% lysozyme was observed from the hydrogels in the first seven days, the remaining 30–50 wt% protein was released in a more sustained profile over a one–month period.Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32.Poloxamers are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules whose self-assembling properties display a wide range of phase behavior. This ability to form micelles and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC).Another important property of Poloxamers is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures. This sol/gel transition have been correlated to the intrinsic changes in the micelle properties, or to the entropic variation in the ordered water molecules close to the PPO segments, or to the possibility of formation of a cross-linked and three-dimensional structure able to entrap water in this network. Neutron scattering studies have demonstrated the formation of a gel structure for a micelle concentration reaching the critical volume fraction of 0.53, which allows locking of the micelles in a hard-sphere, crystalline structure due to their high volume density.Both micellization and gelation depend on different factors: temperature, polymer concentration, and PEO block length.It is for this reason that the Poloxamer 407 phase transitions and the effect of hydroxypropyl β-cyclodextrin (HP β–CD) on them were studied using acoustic spectroscopy with purpose of verifying the relevance of this method in the pharmaceutical field.The poloxamers, also known by the trademark Pluronic, Synperonic and Tetronic, were initially introduced between 1950 and have presented several pharmaceutical applications, as well as, excellent compatibility with other compounds.Studies showed some of the poloxamer’s characteristics, especially thermoresponsiveness, high capacity to solubilize drugs, good drug release characteristics, and absence of toxicity in mucosal membranes, and thus widely recognized in the pharmaceutical area as a safe material.Poloxamers are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide (PO) (OEx–POy–OEx). They are synthesized by polymerization of EO and PO units, in sequence, also in the presence of sodium hydroxide and potassium hydroxide. Poloxamers compounds have the chemical formula HO[CH2CH2O] x[CH(CH3)CH2O] y[CH2CH2O]OH, where y is greater than 14.According to the ratio between hydrophilic (EO) and lipophilic (PO) units, various copolymers block and size can be obtained within different molecular weights and physic-chemical properties .The poloxamer 407 or Pluronic F127 has particularly interest because of the thermoreversible properties, and can be useful in the optimization of drug delivery systems, and employed in many formulations like intravenous preparations, topical, ophthalmic, nasal, vaginal, and rectal, with no irritation or skin sensitivity.Poloxamer 407 aqueous solutions have the property of being a thermoresponsive system, which leads to a sol–gel transition due to temperature increase. When in aqueous dispersions, the individual molecules of the copolymer’s block of P407 self-organize into micelles (micellization), when are in concentrations above the critical micelle concentration (CMC) in order to minimize the free energy from the solution. These micelles can be spherical, cylindrical, or lamellar, depending upon the length in the chain, containing EO and PB, the concentration of polymer and temperature, that leads to increased viscosity.The advantages of poloxamers in liquid pharmaceutical forms are especially because that they allow a comfortable release at the action site, gelling at the site and may have modified release. The disadvantages of these polymers are weak mucoadhesive, and poor mechanical properties, short residence time due to easily dissolution at the action site .Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermoreversible properties, which is of the utmost interest in optimising drug formulation (fluid state at room temperature facilitating administration and gel state above sol–gel transition temperature at body temperature promoting prolonged release of pharmacological agents). Pharmaceutical evaluation consists in determining the rheological behaviour (flow curve or oscillatory studies), sol–gel transition temperature, in vitro drug release using either synthetic or physiological membrane and (bio)adhesion characteristics. Poloxamer 407 formulations led to enhanced solubilisation of poorly water-soluble drugs and prolonged release profile for many galenic applications (e.g., oral, rectal, topical, ophthalmic, nasal and injectable preparations) but did not clearly show any relevant advantages when used alone. Combination with other excipients like Poloxamer 188 or mucoadhesive polymers promotes Poloxamer 407 action by optimising sol–gel transition temperature or increasing bioadhesive properties. Inclusion of liposomes or micro(nano)particles in Poloxamer 407 formulations offers interesting prospects, as well. Besides these promising data, Poloxamer 407 has been held responsible for lipidic profile alteration and possible renal toxicity, which compromises its development for parenteral applications. In addition, new findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.

Polyvinylpyrrolidone; poly(1-vinylpyrrolidinone); polyvinylpyrrolidone; povidone; N- vinylpyrrolidone polymer; PVP K 90; PVP, Povidone; PVPP, Crospovidone, Polyvidone; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer ; 1-Vinyl-2-pyrrolidinon-Polymere cas no: 9003-39-8

cas no 9002-88-4 Ethene, homopolymer; polyetylene;

SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6

Poloxamer is nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)).


CAS Number: 106392-12-5
EC Number: 923-642-1



Poloxamer is nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene.
Poloxamer is nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)).


The word Poloxamer was coined by BASF inventor, Irving Schmolka, who received the patent for these materials in 1973.
Poloxamer is also known by the trade names Pluronic, Kolliphor (pharma grade), and Synperonic.
Because the lengths of the polymer blocks can be customized, many different Poloxamer exists that have slightly different properties.


For the generic term Poloxamer, these copolymers are commonly named with the letter P (for Poloxamer) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = Poloxamer with a polyoxypropylene molecular mass of 4000 g/mol and a 70% polyoxyethylene content).


Poloxamer is also known as polyethylene- propylene glycol copolymer or polyoxvethylene-polyoxypropylene copolymer.
Poloxamer is a series of block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO).
All poloxamers are chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture.


The presence of PEO and PPO blocks in a single polymer chain imparts to the molecule amphiphilic properties whose self-assembling properties display a wide range of phase behaviour.
Several different types of poloxamers are commercially available whose physical and surface-active properties vary over a wide range.


Pharmacopoeial grades generally occur as white, waxy, granules or as solids.
They are practically odourless and tasteless.
Poloxamers are listed in pharmacopoeia and generally regarded as nontoxic and non-irritant.


Included in the FDA Inactive Ingredients Database (IV injections; inhalations, ophthalmic preparations; oral powders. solutions, suspensions, and syrups; topical preparations).
Poloxamer is nonionic triblock copolymers consisting of a central hydrophobic polyoxypropylene chain surrounded by two hydrophilic polyoxyethylene chains.


Poloxamer is nonionic polyoxyethylene-polyoxypropylene polymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.
The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic.



USES and APPLICATIONS of POLOXAMER:
Because of their amphiphilic structures, Poloxamer has surfactant properties that make them useful in industrial applications.
Among other things, Poloxamer can be used to increase the water solubility of hydrophobic, oily substances or otherwise increase the miscibility of two substances with different hydrophobicities.
For this reason, Poloxamer is commonly used in industrial applications, cosmetics, and pharmaceuticals.


Poloxamer has also been evaluated for various drug delivery applications and were shown to sensitize drug-resistant cancers to chemotherapy.
In bioprocess applications, Poloxamer is used in cell culture media for their cell cushioning effects because their addition leads to less stressful shear conditions for cells in reactors.


There are grades of Poloxamer commercially available specifically for cell culture, including Kolliphor P 188 Bio.
In materials science, the Poloxamer has recently been used in the synthesis of mesoporous materials, including SBA-15.
When mixed with water, concentrated solutions of Poloxamer can form hydrogels.


These gels can be extruded easily, acting as a carrier for other particles, and used for robocasting.
The main uses of Poloxamer is as dispersing agents, emulsifying agents, solubilizing agents, tablet lubricants, wetting agents and foaming agents.
As nonionic polyoxyethylene-polyoxypropylene copolymers, Poloxamer is used as emulsifying or solubilizing agents.


Poloxamer is used as emulsifying agents in intravenous fat emulsions and as solubilizing and stabilizing agents to maintain clarity of elixirs and syrups.
Poloxamer can also be used as wetting agents; in ointments, suppository bases, and gels; and in tablet binders and coatings. Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems.


More recently, poloxamers have found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as dantron.


Poloxamer may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer is used in the cosmetics field as oil-in-water emulsifiers, cleansers for mild facial products, and dispersing agents.
Nowadays, Poloxamer is widely used in different drug delivery systems due to its biodegradability, high solubility and low toxicity.


Poloxamer contains both hydrophilic and hydrophobic moieties, so they are widely used as surfactants and emulsifiers in formulation.
Poloxamer is used as a solubility enhancer in solid dispersion.
Pluronic grade has thermo-reversible gelation property, transforming into liquid at room temperature and gel at body temperature, hence used in control release formulation.


Poloxamer is used to improve the stability of Nanoparticle and liposome.
Poloxamer is used in solid suppositories to improve the dissolution of poorly soluble drugs and reduce rectal irritation compared to traditional polymer such as polyethylene glycol.


Poloxamer is also used as a stabilizer in biological.
Medicines that contain poloxamer: Coloxyl Drops
All of the poloxamer is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture.


Their physical and surface-active properties vary over a wide range and a number of different types are commercially available.
Poloxamer is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups.


Poloxamer may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems.


More recently, poloxamers have found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron.
Poloxamer may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.


Poloxamer is a type of non-ionic surfactant that is used as an emulsifier, stabilizer, and thickening agent in a variety of products, including dietary supplements.
Poloxamer is also used as a lubricant in some medical and pharmaceutical products.



HOW IS POLOXAMER USED IN THE FOOD INDUSTRY?
Poloxamer is a type of dietary supplement that is used in the food industry as an emulsifier, stabilizer, and thickening agent.
Poloxamer is used to improve the texture, stability, and shelf life of food products.
Poloxamer is also used to reduce fat and sugar content in food products, as well as to improve the flavor and texture of processed foods.



WHY IS POLOXAMER USED?
Poloxamer helps to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent
Substances, usually liquids, Poloxamer is used to dissolve other substances.
Poloxamer also clean the skin and hair by helping water to mix with oil and dirt so that they can be rinsed away. Poloxamer 188 kills microorganisms, or prevents or inhibits their growth and reproduction.
Poloxamer 182 Dibenzoate acts as a lubricant on the skin’s surface, which gives the skin a soft and smooth appearance.



WHERE IS POLOXAMER USED?
Poloxamer is a type of dietary supplement that is used to treat a variety of conditions, including constipation, diarrhea, and irritable bowel syndrome.
Poloxamer is also used to reduce cholesterol levels and to treat certain types of infections.



ACTIVE INGREDIENT OF POLOXAMER:
The medicines below all contain the following active ingredient(s): poloxamer.
You can select a medicine from this list to find out more - including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS).



HEALTH BENEFITS OF POLOXAMER?
Poloxamer is a type of dietary supplement that has been found to have a number of health benefits.
Poloxamer has been shown to reduce inflammation, improve joint health, and reduce the risk of cardiovascular disease.
Poloxamer has also been found to help reduce cholesterol levels, improve digestion, and reduce the risk of certain types of cancer.
Additionally, Poloxamer has been found to help improve skin health, reduce the risk of diabetes, and improve overall immune system function.



BENEFITS AND CLAIMS OF POLOXAMER:
*Fast dispersion and rapid emulsification from large droplet to medium sized droplet.
*Hydrophilic coating of surfactant on oil droplets minimizes the lipid digestion.
*Formation of other secondary structures such as micelles, chylomicron in the GIT fluids which helps in drug absorption
*Non-digestible solubiliser to minimize drug precipitation in the GIT



POLOXAMER IS SUITABLE FOR:
*Cream / Emulsion
*Gel
*Softgel Capsules



BENEFITS OF POLOXAMER:
*Aqueous solution containing more than 20% Poloxamer concentration demonstrate themoreversible viscosity
*Clinically tested for mildness and are less irritating upon topical application
*Various grades available to suit different applications
*Poloxamer can be processed via hot melt extrusion (HME) or spray drying
*Poloxamer is applicable for oral, topical, or parenteral applications



MICELLIZATION AND PHASE TRANSITIONS OF POLOXAMER:
An important characteristic of Poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior.
Concentrated aqueous solutions of Poloxamer are liquid at low temperature and form a gel at higher temperature in a reversible process.
The transitions that occur in these systems depend on Poloxamer composition (molecular weight and hydrophilic/hydrophobic molar ratio).
At low temperatures and concentrations (below the critical micelle temperature and critical micelle concentration) individual block copolymers (unimers) are present in solution.

Above these values, aggregation of individual unimers occurs in a process called micellization.
This aggregation is driven by the dehydration of the hydrophobic polyoxypropylene block that becomes progressively less soluble as the polymer concentration or temperature increases.

The aggregation of several unimers occurs to minimize the interactions of the PPO blocks with the solvent.
Thus, the core of the aggregates is made from the insoluble blocks (polyoxypropylene) while the soluble portion (polyoxyethylene) forms the shell of the micelles.

The mechanisms on the micellization at equilibrium have shown to depend on two relaxation times:
(1) the first and fastest (tens of the microseconds scale) corresponds to the unimers exchange between micelles and the bulk solution and follows the Aniansson-Wall model (step-by-step insertion and expulsion of single polymer chains), and
(2) the second and much slower one (in the millisecond range) is attributed to the formation and breakdown of whole micellar units leading to the final micellar size equilibration.

Besides spherical micelles, elongated or worm-like micelles can also be formed.
The final geometry will depend on the entropy costs of stretching the blocks, which is directly related to their composition (size and polyoxypropylene/polyoxyethylene ratio).

The mechanisms involved in the shape transformation are different compared to the dynamics of micellization.
Two mechanisms were proposed for the sphere-to-rod transitions of block copolymer micelles, in which the micellar growth can occur by (A) fusion/fragmentation of micelles or (B) concomitant fusion/fragmentation of micelles and unimer exchange, followed by smoothing of the rod-like structures.

With higher increments of the temperature and/or concentration, other phenomena can occur such as the formation of highly ordered mesophases (cubic, hexagonal and lamellar).
Eventually, a complete dehydration of the polyoxypropylene blocks and the collapse of the polyoxyethylene chains will lead to clouding and/or macroscopic phase separation.

This is due to the fact that hydrogen bonding between the polyoxyethylene and the water molecules breaks down at high temperature and polyoxyethylene becomes also insoluble in water.
The phase transitions can also be largely influenced by the use of additives such as salts and alcohols.

The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in).
Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration.

Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration.
The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power.

Different phase diagrams characterizing all these transitions have been constructed for most poloxamers using a great variety of experimental techniques (e.g. SAXS, Differential scanning calorimetry, viscosity measurements, light scattering).



BIOLOGICAL EFFECT OF POLOXAMER:
Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting.
The Poloxamer has been shown to incorporate into cellular membranes affecting the microviscosity of the membranes.
The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle.

On multi drug resistant cancer cells:
Poloxamer has been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells.
Poloxamer has also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin.

Another effect of the polymers upon cancer cells is the inhibition of the production of ATP in multi-drug resistant (MDR) cancer cells.
The polymers seem to inhibit respiratory proteins I and IV, and the effect on respiration seems to be selective for MDR cancer cells, which may be explained by the difference in fuel sources between MDR and sensitive cells (fatty acids and glucose respectively).

Poloxamer has also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles.

On nuclear factor kappa B:
Certain Poloxamers such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression.
Certain poloxamers, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa.

Potential degradation by sonication:
Wang et al. reported that aqueous solutions of poloxamer 188 (Pluronic F-68) and poloxamer 407 (Pluronic F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells.
Moreover, toxicity correlated with the sonolytic degradation of the polymers.



ANY USEFUL TIPS OF POLOXAMER:
Naming of Poloxamer can be bewildering but typically, the nonproprietary name – poloxamer – is followed by a number: the first two digits of which, when multiplied by 100, correspond to the approximate average molecular weight of the polyoxypropylene portion of the copolymer and the third digit, when multiplied by 100, corresponds to the percentage by weight of the polyoxyethylene portion.

Similarly, with many of the trade names used for Poloxamer e.g. Kolliphor 188, the first digit arbitrarily represents the molecular weight of the polyoxypropylene portion and the second digit represents the weight percent of the oxyethylene portion.
The letters L, ‘P’, and ‘F’, stand for the physical form of the Poloxamer: liquid, paste, or flakes.

Although the USP-NF contains specifications for five poloxamer grades, many more different poloxamers are commercially available that vary in their molecular weight and the proportion of oxyethylene present in the polymer.
Some poloxamers (e.g Poloxamer 188) are incompatible with parabens.



WHAT IS POLOXAMER?
Poloxamers (Poloxamer 101, Poloxamer 105, Poloxamer 108, Poloxamer 122, Poloxamer 123, Poloxamer 124, Poloxamer 181, Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 185, Poloxamer 188, Poloxamer 212, Poloxamer 215, Poloxamer 217, Poloxamer 231, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 282, Poloxamer 284, Poloxamer 288, Poloxamer 331, Poloxamer 333, Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamer 401, Poloxamer 402, Poloxamer 403, Poloxamer 407, Poloxamer 105 Benzoate, Poloxamer 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene.

The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer
A naturally occurring or synthetic molecule made up of repeating units called monomers.
For example, the smallest polymer, Poloxamer 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene.

Poloxamers range from colorless liquids and pastes to white solids.
In cosmetics and personal care products, Poloxamer is used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.



PHYSICAL and CHEMICAL PROPERTIES of POLOXAMER:
Chemical Name: Poloxamer
CAS Registration Number: [9003-11-6]
Empirical Formula: HO(C2H4O)a(C3H6O)b(C2H4O)aH
Molecular weight: 2090 – 14 600 (average)
Regulatory Status: PhEur; USP-NF; JPE
Acidity/aikalinity: pH = 5.0—7.4 for a 2.5% w/v aqueous solution
Cloud point: > 100C for a 1% w/s aqueous solution, and a 10% w/v aqueous solution of poloxamer 188
HLB value: 0.5 – 30
Melting Point: 16oC for poloxamer 124; 52 – 57oC for poloxamer 188;
49oC for poloxamer 237; 57oC for poloxamer 338 and 52-57 oC for poloxamer 407
Solubilitiy: Solubility varies according to the poloxamer type
Surface tension: 19.8 mN/m for a 0.1% w/v aqueous poloxamer 188 solution at 25C;
24.0mN/m for a 0.01% w/w aqueous poloxamer 188 solution at 25C;
26.0 mN/m for a 0.001% w/v aqueous poloxamer solution at 25 C

Viscosity (dynamic): 1000 mPas as a melt at 77C for poloxamer 188
Physical state: liquid
Color: No data available
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available

Physical data:
HLB values:
Poloxamer 124: 12 - 18
Poloxamer 188, 338: > 24
Poloxamer 407: 18 - 23
Oxyethylene content (%):
Poloxamer 124: 44.8 - 48.6%
Poloxamer 188: 79.9 - 83.7%
Poloxamer 338: 81.4 - 84.9%
Poloxamer 407: 71.5 - 74.9%



FIRST AID MEASURES of POLOXAMER:
Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLOXAMER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of POLOXAMER:
-Extinguishing media:
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLOXAMER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
not required
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLOXAMER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of POLOXAMER:
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available

Poloxamer 124 is a polyoxyethylene, polyoxypropylene block polymer.
Poloxamer 124 is known for its ability to create a smooth, silky texture and its non-irritating and non-sensitizing properties.
The chemical formula of Poloxamer 124 is C5H10O2.


CAS Number: 9003-11-6
EC Number: 618-355-0
MDL Number: MFCD00082049
Chem/IUPAC Name: Oxirane, methyl-, polymer with oxirane (11;21)
Molecular Formula: C5H10O2



Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL, SYNPERONIC F 108, SYNPERONIC L 121, SYNPERONIC L 122, SYNPERONIC P 105, SYNPERONIC P 85, SYNPERONIC PE(R)/F68, SYNPERONIC PE(R)/L61, Polyethylene-Polypropylene Glycol, Pluronic L44 INH, Lutrol, Monolan, Pluronic, poloxalkol, poloxamera, polyethylene-propylene glycol copolymer, polyoxyethylene-polyoxypropylene copolymer, Supronic, Synperonic,



Poloxamer 124 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products.
This water-soluble polymer, Poloxamer 124, helps in emulsifying and stabilizing formulations, improving the texture, and enhancing the appearance of products.


Poloxamer 124 is a milky white paste or a colorless or almost colorless liquid.
Poloxamer 124 is soluble in water and in ethanol, practically insoluble in light petroleum.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.


Poloxamer 124 is a synthetic
Poloxamer 124 is a cGMP Pharmaceutical Grade Excipient and is the only monographed poloxamer that is liquid at room temperature − making it ideal for a broad range of dosage forms.


As a liquid amphiphilic polymer, Poloxamer 124 helps solubilize APIs in the formulation.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.


Poloxamers are block copolymers composed of ethylene oxide and propylene oxide.
With the suffixed number the mass percentages of the two components as well as the overall molecular mass are encoded.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.



USES and APPLICATIONS of POLOXAMER 124:
Poloxamer 124 is often used in skincare products such as creams, lotions, and serums, as well as in some makeup products and hair care products.
Poloxamer 124 is a versatile ingredient used in a wide range of cosmetics and personal care formulations due to its texture-enhancing and emulsifying properties.


Poloxamer 124 is often added to products like creams and serums to create a smooth and silky texture and to improve the overall appearance and feel of the product.
Additionally, Poloxamer 124 can help to solubilize and stabilize other ingredients in make up and hair care formulations.
Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.


Poloxamer 124 is also known for its non-irritating and non-sensitizing properties, making it suitable for use in products designed for sensitive skin.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.


Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.
Poloxamer 124 can be used as an excipient, such as Dispersant, emulsifier, solubilizer, lubricant, wetting agent, etc.
Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients.


Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations.
Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.


Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.
Poloxamer 124 is a High-HLB emulsiier that is commonly used in cleansing water formulas.
Poloxamer 124 is used to wash cosmetics.
Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.



ORIGIN OF POLOXAMER 124:
Poloxamer 124 is synthesized by the polymerization of propylene oxide and ethylene oxide, resulting in a block copolymer with a hydrophobic polypropylene oxide segment and a hydrophilic polyethylene oxide segment.
Poloxamer 124 appears as a white to off-white, waxy solid.



WHAT DOES POLOXAMER 124 DO IN A FORMULATION?
*Emulsifying
*Surfactant



FUNCTIONS OF POLOXAMER 124:
*Emulsifying :
Poloxamer 124 promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)
*Surfactant :
Poloxamer 124 reduces the surface tension of cosmetics and contributes to the even distribution of the product when it is used



BENEFITS OF POLOXAMER 124:
*Only monographed poloxamer that is liquid at room temperature
Ideal for liquid dosage forms
*Poloxamer 124 has melting point around 16°C and a hydrophiilic-lipophilic balance (HLB) value between 12-18
*Poloxamer 124 is used for liquid-filled softgel capsules as a dispersion medium for APIs, or as plasticizer for tablet formulations
*Poloxamer 124 is suitable for softgels, creams, foams, gels and emulsions




FUNCTIONS OF POLOXAMER 124 IN COSMETIC PRODUCTS:
*SURFACTANT - CLEANSING:
Surface-active agent to clean skin, hair and / or teeth

*SURFACTANT - EMULSIFYING:
Poloxamer 124 allows the formation of finely dispersed mixtures of oil and water (emulsions)



SAFETY PROFILE OF POLOXAMER 124:
Poloxamer 124 is a safe ingredient.
Poloxamer 124 is non irritating and non-comedogenic, so it does not cause any sensitivity issues or acne.
However, a patch test should be performed.
Additionally, since Poloxamer 124 is a synthetic ingredient, it is generally considered vegan and halal.



ALTERNATIVES OF POLOXAMER 124:
*CETEARETH20,
*POLYGLYCERYL3 DIISOSTEARATE,
*SORBITAN STEARATE



PHYSICAL and CHEMICAL PROPERTIES of POLOXAMER 124:
Physical state: powder
Color: No data available
Odor: No data available
Melting point/freezing point: 56,8 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature:
No data available
Decomposition
temperature:
No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available

Water solubility: No data available
Partition coefficient:
n-octanol/water:
No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Melting Point: 50-60°C
pH: 7.0
Solubility: Highly soluble in water
Viscosity: Low

CAS: 9003-11-6
Molecular Formula: C5H10O2
Molecular Weight (g/mol): 102.13
InChI Key: RVGRUAULSDPKGF-UHFFFAOYNA-N
IUPAC Name: 2-methyloxirane; oxirane
SMILES: C1CO1.CC1CO1
pH: 5.0 to 7.5
CAS Max %: 1
Water: 0.004
IUPAC Name: 2-methyloxirane;oxirane
Molecular Formula: C5H10O2
Canonical SMILES: CC1CO1.C1CO1
InChI Key: RVGRUAULSDPKGF-UHFFFAOYSA-N
Boiling Point: 32.9ºC at 760 mmHg
Melting Point: 60-50°C
Flash Point: 55.2°C
Density: 1.095 g/mL at 25°C

Appearance: White crystalline powder
Assay: 0.99
EC Number: 618-355-0
Exact Mass: 102.06800
Refractive Index: n20/D 1.466
Safety Description: 23-24/25-45-36/37/39-26
pH: 5.0 to 7.5
CAS Max %: 1
SMILES: C1CO1.CC1CO1
Molecular Weight (g/mol): 102.13
CAS:9003-11-6
Molecular Formula: C5H10O2
InChI Key: RVGRUAULSDPKGF-UHFFFAOYNA-N
IUPAC Name: 2-methyloxirane; oxirane
Grade: Reagent
Water: 0.004



FIRST AID MEASURES of POLOXAMER 124:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLOXAMER 124:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of POLOXAMER 124:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLOXAMER 124:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Respiratory protection:
Recommended Filter type: Filter type P1
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLOXAMER 124:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of POLOXAMER 124:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available

Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.
Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.
Poloxamer 124 is a polyoxyethylene, polyoxypropylene block polymer.

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

Poloxamer 124 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products.
This water-soluble polymer helps in emulsifying and stabilizing formulations, improving the texture, and enhancing the appearance of products.
Poloxamer 124 is often used in skincare products such as creams, lotions, and serums, as well as in some makeup products and hair care products.
Poloxamer 124 is known for its ability to create a smooth, silky texture and its non-irritating and non-sensitizing properties.
The chemical formula of Poloxamer 124 is C5H10O2.
Poloxamer 124 is synthesized by the polymerization of propylene oxide and ethylene oxide, resulting in a block copolymer with a hydrophobic polypropylene oxide segment and a hydrophilic polyethylene oxide segment.

Poloxamer 124 appears as a white to off-white, waxy solid.
Poloxamer 124 is a safe ingredient and has a very low toxicity profile.
Poloxamer 124 is non irritating and non-comedogenic, so it does not cause any sensitivity issues or acne.
However, a patch test should be performed.
Additionally, since Poloxamer 124 is a synthetic ingredient, it is generally considered vegan and halal.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.

Poloxamer 124 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 124 (9003-11-6)

Uses
Poloxamer 124 is a versatile ingredient used in a wide range of cosmetics and personal care formulations due to its texture-enhancing and emulsifying properties.
Poloxamer 124 is often added to products like creams and serums to create a smooth and silky texture and to improve the overall appearance and feel of the product.
Additionally, Poloxamer 124 can help to solubilize and stabilize other ingredients in make up and hair care formulations.
Poloxamer 124 is also known for its non-irritating and non-sensitizing properties, making it suitable for use in products designed for sensitive skin.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
Poloxamer 124 was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
Poloxamer 124 was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the Poloxamer 124 base plus the weight of added ethylene oxide.

Reports of adverse Effects
It was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used Poloxamer 124 as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 124 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000

SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6

SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6

SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6

Poloxamer 188 is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
Poloxamer 188 was originally approved by the FDA in the 1960s as a therapeutic agent to reduce viscosity in the blood before transfusions, however it is no longer available in any approved products.
Due to Poloxamer 188's sufactant properties, P188 may also be found in over-the-counter (OTC) products such as toothpaste, laxatives and mouthwash, and used in various cosmetic, industrial and pharmaceutical applications.

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

There is an evidence of Poloxamer 188 increasing the structural stability and resealing of the plasma membrane via direct incorporation into the phospholipid bilayer.
The ability of Poloxamer 188 in attenuating membrane damage and cell injury has been demonstrated in a variety of in vivo and in vitro models.
The use of Poloxamer 188 as a potential treatment in different pathological conditions, such as chronic microvascular diseases and skeletal muscle deficiencies, is under investigation
Poloxamer 188 is a non-ionic surfactant used to control shear forces in suspension cultures.
Poloxamer 188 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass.
Poloxamer 188 is provided at a concentration of 10% and effective at a working concentration of 0.1%.
Poloxamer 188 BIO is supplied as white to slightly yellowish, coarse grained powder with a waxy consistency.
Poloxamer 188 is freely soluble in ethanol, freely soluble in water (opalescent solution), and is insoluble in diethyl ether, paraffin and fatty oils.

Poloxamer 188 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: <0.3 mm Hg ( 20 °C)
Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at <70 °Csoluble
Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 188 (9003-11-6)

Mechanism of action
Poloxamer 188 seals stable defects in cell membranes induced by skeletal muscle cell membranes rupture induced by ischemia-reperfusion injury, electroporation, irradiation, and heat damage.
The full mechanism of action of Poloxamer 188 in inducing cytoprotective effects is not clear; however, based on in vitro experiments and the structural similarity to plasmalemma, Poloxamer 188 may be directly incorporated into the phospholipid bilayer to attenuate the extent of tissue injury.
Poloxamer 188s high surface activity facilitates P188 to be inserted into lipid monolayers.
Poloxamer 188 is proposed to exert localized actions by only interacting with damaged and compromised bilayers where the local lipid packing density is reduced .
In addition to the direct interaction with the membrane, Poloxamer 188 was shown to inhibit MMP-9 protein levels and activity, as well as the NF-κB signal pathway, in the model of acute cerebral ischemia, which is associated with increased BBB permeability leading to cerebral edema and increased penetration.
Poloxamer 188 is a key factor in extracellular matrix.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
Poloxamer 188 was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
The final product was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the Poloxamer 188 base plus the weight of added ethylene oxide.

Reports of adverse Effects
Poloxamer 188 was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used Poloxamer 188 as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 188 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000

Poloxamer 338 is supplied as white or almost white, coarse grained powder with a waxy consistency.
Poloxamer 338 is freely soluble in water (opalescent solution) and ethanol; insoluble in diethyl ether, paraffin and fatty oils.
Poloxamer 338 primarily used as thickening agents and gel formers but also as wetting agents, as emulsifiers and solubilizers

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

Poloxamer 338 shows characteristic property of thermoreversible gelation upon cooling or heating
The high performance and safety is backed by comprehensive documentation.
Poloxamer 338 , also known as Pluronic, is a nonionic triblock copolymer composed of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) units.
Poloxamer 338 is a clear, viscous liquid or solid at room temperature, depending on its specific grade.
Poloxamers are designated with a number, such as Poloxamer 188 or Poloxamer 338, which indicates their molecular weight and composition.
Poloxamer 338 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant.
Poloxamer 338 consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature.
Poloxamer 338 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products such as contact lens cleaning solutions.

Poloxamer 338 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 338 (9003-11-6)

Uses
Poloxamer 338 has various applications in different industries, including:

Pharmaceutical and medical: Poloxamer 338 is widely used in pharmaceutical formulations and medical applications.
Poloxamer 338 is employed as a solubilizer, emulsifier, and stabilizer in liquid and semi-solid dosage forms such as creams, ointments, gels, and suppositories.
Poloxamer 338 can improve drug solubility, enhance bioavailability, and provide controlled drug release.
They are also utilized in eye drops, nasal sprays, and other topical formulations.

Personal care and cosmetics: Poloxamer 338 is utilized in the personal care and cosmetic industry.
Poloxamer 338 is commonly found in skincare products, cleansers, shampoos, and conditioners.
Poloxamers act as emulsifiers, surfactants, and texture modifiers, providing stability, foam enhancement, and improved sensory properties.

Industrial applications: Poloxamer 338 has industrial applications as well.
Poloxamer 338 is used as a lubricant and dispersant in various industrial processes, including plastics manufacturing, rubber production, and metalworking.
Poloxamer 338 can improve flow properties, reduce friction, and aid in dispersion of particles.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
Poloxamer 338 was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
Poloxamer 338 was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the Poloxamer 338 base plus the weight of added ethylene oxide.

Reports of adverse Effects
Poloxamer 338 was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used it as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 338 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000

POLOXAMER 101;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 101;Classification : Polymère de synthèse;Ses fonctions (INCI).Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile).Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Les poloxamères sont des copolymères non-ioniques à trois blocs, possédant typiquement un bloc central « hydrophobe » de polypropylène glycol (aussi appelé poly(oxyde de propylène)) et deux blocs externes hydrophiles de polyéthylène glycol (aussi appelé poly(oxyde d'éthylène)). Ces copolymères de type poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) ont pour formule générale H(OCH2CH2)x(OCH(CH3)CH2)y(OCH2CH2)xOH ou pour simplifier (EO)x(PO)y(EO)x. Le mot « poloxamère » a été créé par l'inventeur, Irving Schmolka, qui a déposé un brevet pour ces molécules en 1973.Du fait que la longueur des blocs du poloxamère peut être modifiée, il existe beaucoup de poloxamères différents, qui ont des propriétés légèrement différentes.Du fait de leur structure amphiphile, les poloxamères ont des propriétés surfactantes qui les rendent utiles dans le domaine industriel. Entre autres, ils peuvent être utilisés pour augmenter la solubilité dans l'eau de substances hydrophobes et huileuses, ou augmenter la miscibilité de deux substances de différente hydrophobicité.

Poloxamer 407 is an epoxide.
Poloxamer 407 is a lipoprotein secretion inhibitor.
Poloxamer 407 is a liquid surfactant polymer.

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

Polyoxyethylene and polyoxypropylene block polymers are referred to as Poloxamer 407.
Poloxamer 407 are known by the trade name PluronicR followed by a letter and number, either L, F, or P, which refers to liquid, flake, or paste physical forms, respectively.
Poloxamer 407 is a polyoxyethylene polymer and a hydrophilic non-ionic surfactant.
Poloxamer 407 is made up of two blocks of hydrophilic polyethylene glycol on either side of a central hydrophobic polypropylene glycol block.
In cosmetic and personal products, Poloxamer 407 is used as an emulsifier and solubilizer.
Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers.

Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG).
The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units.
This particular compound is also known by the BASF trade name Poloxamer 407 or by the Croda trade name Synperonic PE/F 127.
BASF also offers a pharmaceutical grade, under trade name Kolliphor Poloxamer 407.
Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant.
Poloxamer 407 consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature.
Poloxamer 407 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products such as contact lens cleaning solutions.

Poloxamer 407 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 407 (9003-11-6)

Poloxamer 407 generally occur as white, waxy, free-flowing prilled granules, or as cast solids.
They are practically odorless and tasteless.
At room temperature, Poloxamer 407 occurs as a colorless liquid.

Uses
Hard and soft surface cleaners, defoamers in coatings and water treatment.
Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.
Most of the common uses of Poloxamer 407 are related to its surfactant properties.
For example, Poloxamer 407 is widely used in cosmetics for dissolving oily ingredients in water.
Poloxamer 407 can also be found in multi-purpose contact lens cleaning solutions, where its purpose there is to help remove lipid films from the lens.
Poloxamer 407 can also be found in some mouthwashes.
There is research ongoing for using Poloxamer 407 for aligning severed blood vessels before gluing them surgically.
Poloxamer 407 can also be used for its thermogelling properties in aqueous media.
Poloxamer 407 is approved by the FDA for use as an excipient in a range of pharmaceutical dosage forms, and is listed in the Inactive Ingredient Database (IID).
Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties.
In a 30% solution by weight, poloxamer 407 forms a gel solid at room temperature but liquifies when chilled to 4 °C (39 °F).
This allows poloxamer 407 to serve as a removable support material, particularly for creating hollow channels or cavities inside hydrogels.
In this role, Poloxamer 407 is often referred to as a "sacrificial ink" or a "fugitive ink".

Pharmaceutical Applications
Poloxamer 407 is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.
The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic.
All of the Poloxamer 407 is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture.
Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;
Poloxamer 407 is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups.

Poloxamer 407 may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 407 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems.
More recently,Poloxamer 407 has found use in drug-delivery systems.
Therapeutically, Poloxamer 407 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; Poloxamer 407 is usually used in combination with a laxative such as danthron.
Poloxamer 407 may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.

Production Methods
Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol.
Ethylene oxide is then added to form the block copolymer.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
The product was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
The final product was a water insoluble Poloxamer 407polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.

Reports of adverse Effects
Poloxamer 407 was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used Poloxamer 407 as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000

POLOXAMER 124;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 101;Classification : Polymère de synthèse;Ses fonctions (INCI).Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile).Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Les poloxamères sont des copolymères non-ioniques à trois blocs, possédant typiquement un bloc central « hydrophobe » de polypropylène glycol (aussi appelé poly(oxyde de propylène)) et deux blocs externes hydrophiles de polyéthylène glycol (aussi appelé poly(oxyde d'éthylène)). Ces copolymères de type poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) ont pour formule générale H(OCH2CH2)x(OCH(CH3)CH2)y(OCH2CH2)xOH ou pour simplifier (EO)x(PO)y(EO)x. Le mot « poloxamère » a été créé par l'inventeur, Irving Schmolka, qui a déposé un brevet pour ces molécules en 1973.Du fait que la longueur des blocs du poloxamère peut être modifiée, il existe beaucoup de poloxamères différents, qui ont des propriétés légèrement différentes.Du fait de leur structure amphiphile, les poloxamères ont des propriétés surfactantes qui les rendent utiles dans le domaine industriel. Entre autres, ils peuvent être utilisés pour augmenter la solubilité dans l'eau de substances hydrophobes et huileuses, ou augmenter la miscibilité de deux substances de différente hydrophobicité.

POLOXAMER 181;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 101;Classification : Polymère de synthèse;Ses fonctions (INCI).Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile).Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Les poloxamères sont des copolymères non-ioniques à trois blocs, possédant typiquement un bloc central « hydrophobe » de polypropylène glycol (aussi appelé poly(oxyde de propylène)) et deux blocs externes hydrophiles de polyéthylène glycol (aussi appelé poly(oxyde d'éthylène)). Ces copolymères de type poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) ont pour formule générale H(OCH2CH2)x(OCH(CH3)CH2)y(OCH2CH2)xOH ou pour simplifier (EO)x(PO)y(EO)x. Le mot « poloxamère » a été créé par l'inventeur, Irving Schmolka, qui a déposé un brevet pour ces molécules en 1973.Du fait que la longueur des blocs du poloxamère peut être modifiée, il existe beaucoup de poloxamères différents, qui ont des propriétés légèrement différentes.Du fait de leur structure amphiphile, les poloxamères ont des propriétés surfactantes qui les rendent utiles dans le domaine industriel. Entre autres, ils peuvent être utilisés pour augmenter la solubilité dans l'eau de substances hydrophobes et huileuses, ou augmenter la miscibilité de deux substances de différente hydrophobicité.

POLOXAMER 184;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 184;Classification : Polymère de synthèse, Tensioactif non ionique;À SAVOIRLe Poloxamer 184, est un tensioactif non ionique composé de trois blocs polymères. lI est utilisé dans la formulation de nettoyants pour la peau, de produits de bain, de shampooings, de revitalisants, de bains de bouche, de démaquillants pour les yeux et d'autres produits pour la peau et les cheveux. On le retrouve très présent dans les eaux micellaires.Ses fonctions (INCI); Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile); Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation

POLOXAMER 185. N° CAS : 9003-11-6. Nom INCI : POLOXAMER 185. Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation

POLOXAMER 188;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 188;Classification : Polymère de synthèse;Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation

POLOXAMER 231, N° CAS : 9003-11-6. Nom INCI : POLOXAMER 231. Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation

POLOXAMER 338; N° CAS : 9003-11-6; Origine(s) : Synthétique;Nom INCI : POLOXAMER 338;Classification : Polymère de synthèse;Ses fonctions (INCI);Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile);Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation

POLOXAMER 407, N° CAS : 9003-11-6, Origine(s) : Synthétique, Nom INCI : POLOXAMER 407, Classification : Polymère de synthèse. Le poloxamère 407, est un tensioactif non ionique appartenant à la classe des copolymères. Il est utilisé dans les produits cosmétiques pour dissoudre les ingrédients huileux dans l'eau. On le trouve assez souvent dans les bains de bouche. Ses fonctions (INCI): Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation

Poly Aluminum Chloride; Polyaluminum chlorohydrate; PAC; Polyaluminum hydroxychloride; cas no: 1327-41-9

Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Polihexanide HCl; Lavasept; BG-IR; Arlagard E; Acticide SR 1296; polihexanidum CAS NO:32289-58-0

DESCRIPTION:
Poly(1-vinylpyrrolidone-co-vinyl Acetate) can be used as a starting material to prepare a quasi-solid polymer electrolyte (QSPE) for dye-sensitized solar cells.

Poly(1-vinylpyrrolidone-co-vinyl Acetate) can be used to preparepolymer blend membranes for pervaporation separation of ethanol and2-ethylhexanol mixtures.

CAS number 25086-89-9

EINECS:200-001-8

MF: C10H15NO3

MW: 197.23



SYNONYMS OF POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone; aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone;


Poly(1-vinylpyrrolidone-co-vinyl Acetate) is a water-soluble polymer resin, which is a white powder, odorless and tasteless, easy to absorb moisture, soluble in water, ethanol and anhydrous alcohols, and has good adhesion, hygroscopicity and film-forming properties. and surface activity.

APPLICATIONS OF POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE):
Pharmaceutical field: VA64 is mainly used as a water-soluble adhesive and dry adhesive in granulation and direct compression technology, as a film-forming material in film coating, and as a channel former in taste-masking agents.
Poly(1-vinylpyrrolidone-co-vinyl Acetate) is applied to the sugar coating to prevent splintering, and the bottom coating is used to prevent moisture.

Industrial fields:
Poly(1-vinylpyrrolidone-co-vinyl Acetate) is used in industry as rewetting adhesives, adhesives for paper, adhesives for coatings, thickeners and protective colloids for various inks, emulsifiers commonly used in plant protection agents and protective colloid.


CHEMICAL AND PHYSICAL PROPERTIES OF POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
Product Name: Poly(1-vinylpyrrolidone-co-vinyl acetate)
form
powder
Quality Level
200
mol wt
average Mw ~50,000 (GPC vs. poly(ethylene oxide))
transition temp
Tg 64 °C
density
1.27 g/mL at 25 °C (lit.)
InChI
1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChI key
FYUWIEKAVLOHSE-UHFFFAOYSA-N
Appearance Colorless to Light orange to Yellow clear liquid
Total Nitrogen 4.2 to 4.8 %
Evaporation residue 46.0 to 54.0 %
Viscosity 800.0 to 3,000.0 mPa-s
Appearance White or slightly yellow hygroscopic powder or flakes
Solubility Soluble in water, 96% ethanol or chloroform
Identify A, B Meet the requirments
Solution Appearance Clear to cloudy
PH 3.0-7.0
Aldehyde ppm ≤500
Peroxide ppm ≤ 400
NVP ppm ≤ 10.0
Vinyl acetate ppm ≤ 5.0
Saponification value mg/g 230-270
Residue on ignition% ≤ 0.1
Vinyl acetate% 35.3-42.0
Hydrazine ppm ≤ 1.0
2-P% ≤ 0.5
Moisture% ≤ 5.0
Heavy metal ppm ≤ 20
Nitrogen content% 7.0-8.0
K value 26.0- 36.0
Appearance: White powder
Test: ≥99.00%
Density: 1.27
Boiling point: 217.6°C at 760 mmHg
Flash point: 254.7±28.5°C
Vapor pressure: 0.0±1.4 mmHg at 25°C
Refractive index: 1.517
Stability: Stable. Fuel, especially in powder form. Incompatible with strong oxidizing agents, strong reducing agents.
Vapor pressure: 0.132mmHg at 25°C
density 1.27 g/mL at 25 °C (lit.)
form powder
InChI key FYUWIEKAVLOHSE-UHFFFAOYSA-N
InChI 1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
mol wt average Mw ~50,000 (GPC vs. poly(ethylene oxide))
Quality Level 200
transition temp Tg 64 °C





SAFETY INFORMATION ABOUT POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

Poly(ethylene glycol) methyl ether 1000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2



Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 1000 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 1000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 1000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 1000 is Powder.
Poly(ethylene glycol) methyl ether 1000, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 1000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 1000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 1000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 1000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 1000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 1000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 1000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 1000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 1000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 1000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 1000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1000 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
Poly(ethylene glycol) methyl ether 1000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 1000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 1000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 1000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 1000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 1000 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 1000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 1000 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 1000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 1000 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 1000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 1000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1000 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 1000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 1000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 1000 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1000 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 1000 is available in powder form.


Poly(ethylene glycol) methyl ether 1000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 1000 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 1000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 1000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 1000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 1000 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 1000 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 1000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 1000.
Poly(ethylene glycol) methyl ether 1000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Poly(ethylene glycol) methyl ether 1000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 1000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 1000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 1000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 1000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
Poly(ethylene glycol) methyl ether 1000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
Physical state: Solid (pellets, flakes)
Color: Colorless
Odor: No data available
Melting point/freezing point: Melting point/range: 20 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 182 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity: Viscosity, kinematic: No data available; Viscosity, dynamic: No data available

Water solubility at 20 °C: Slightly soluble
Partition coefficient (n-octanol/water): No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available
Product Type: PEGylation Reagents
Group 1: OH

Form (20 deg.C): Solid
Storage Condition: Room temperature (Recommended in a cool and dark place, <15°C)
CAS RN: 9004-74-4
PubChem Substance ID: 253662346
MDL Number: MFCD00084416
Purity: n/a
Size: 100G
Unit: EA
Molecular Formula/Molecular Weight: n/a
CAS No: 9004-74-4
Physical State: Solid

Color: White
Melting Point: 40 °C
Condition to Avoid: n/a
Refractive Index: n/a
Specific Gravity: n/a
MDL No: MFCD00084416
SDBS: n/a
MINUM: n/a
PUBCSUB: 253662346
UNSPSC: 12352100
UN No: n/a
Hazard Class: n/a
DOT Name: n/a
Pkg Grp: n/a
TSCA: Yes



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Poly(ethylene glycol) methyl ether 1500, with an average molecular weight of 1500, is widely used in various industries.
Poly(ethylene glycol) methyl ether 1500is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether



Poly(ethylene glycol) methyl ether 1500 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1500 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 1500 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 1500 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 1500 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1500 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 1500 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 1500 is Powder.
Poly(ethylene glycol) methyl ether 1500, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 1500is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1500 has a range of potential uses.


Poly(ethylene glycol) methyl ether 1500, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 1500 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 1500 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 1500 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 1500 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 1500, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1500 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 1500 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 1500, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 1500, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 1500, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1500 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
Poly(ethylene glycol) methyl ether 1500 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1500 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 1500 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 1500 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 1500 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 1500 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 1500 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 1500 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 1500 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 1500 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 1500 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 1500 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1500 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 1500 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1500 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 1500 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 1500 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 1500 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1500 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 1500 is available in powder form.


Poly(ethylene glycol) methyl ether 1500 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 1500 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 1500 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 1500 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 1500 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 1500 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 1500 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 1500 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 1500.
Poly(ethylene glycol) methyl ether 1500, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Poly(ethylene glycol) methyl ether 1500 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 1500 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 1500 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 1500's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 1500's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
Poly(ethylene glycol) methyl ether 1500 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
Physical state: Pellets, flakes
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 20°C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182°C - closed cup
Autoignition temperature: Not available
Decomposition temperature: Not available

pH: Not available
Viscosity: Kinematic viscosity: Not available; Dynamic viscosity: Not available
Water solubility at 20°C: Slightly soluble
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Poly(ethylene glycol) methyl ether 2000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 2000 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 2000 is used in pressure-sensitive and thermoplastic adhesives.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, Polyoxyethylene Monomethyl Ether, Poly(Ethylene Oxide) Methyl Ether, Poly(Ethylene Oxide) Monomethyl Ether,a-Methyl-?-hydroxypoly(oxy-1,2-ethanediyl), Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 2000, Methoxypolyethylene glycol, Methoxypolyethylene glycol 2000, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, mPEG thiol, methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em,



Poly(ethylene glycol) methyl ether 2000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 2000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 2000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 2000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 2000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 2000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 2000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 2000 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 2000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 2000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 2000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 2000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 2000 is Powder.
Poly(ethylene glycol) methyl ether 2000, with an average molecular weight of 2000, is widely used in various industries.


Poly(ethylene glycol) methyl ether 2000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 2000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 2000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 2000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 2000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 2000.
Poly(ethylene glycol) methyl ether 2000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 2000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 2000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 2000 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
Due to its low toxicity Poly(ethylene glycol) methyl ether 2000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 2000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 2000 is used for formulating screens or for optimization.
Poly(ethylene glycol) methyl ether 2000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 2000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.
Poly(ethylene glycol) methyl ether 2000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.


In addition, Poly(ethylene glycol) methyl ether 2000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.
Poly(ethylene glycol) methyl ether 2000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.


Moreover, Poly(ethylene glycol) methyl ether 2000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.
Poly(ethylene glycol) methyl ether 2000 is used as enteric release coatings.


Poly(ethylene glycol) methyl ether 2000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 2000 acts as a solvent for brake fluids.
Further, Poly(ethylene glycol) methyl ether 2000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.


In addition to this, Poly(ethylene glycol) methyl ether 2000 is used in surfactants, polyester and polyurethane based paints.
Poly(ethylene glycol) methyl ether 2000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 2000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) methyl ether 2000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 2000 is intended for laboratory use only, and it is not meant for human consumption.
Poly(ethylene glycol) methyl ether 2000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 2000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.


Poly(ethylene glycol) methyl ether 2000 is a versatile compound commonly used in various applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 2000 has a range of potential uses.


With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 2000 is available in powder form.
Poly(ethylene glycol) methyl ether 2000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 2000 is also used as a wetting agent and viscosity modifier.


Poly(ethylene glycol) methyl ether 2000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.
Crystallization grade Poly(ethylene glycol) methyl ether 2000 is used for formulating screens or for optimization


Poly(ethylene glycol) methyl ether 2000 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 2000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 2000.
Poly(ethylene glycol) methyl ether 2000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Poly(ethylene glycol) methyl ether 2000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 2000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 2000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 2000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 2000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
Poly(ethylene glycol) methyl ether 2000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
Physical state: Pellets, flakes
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 20°C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182°C - closed cup
Autoignition temperature: Not available
Decomposition temperature: Not available
pH: Not available
Viscosity:
Kinematic viscosity: Not available;
Dynamic viscosity: Not available

Water solubility at 20°C: Slightly soluble
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available
Formula: CH3O(CH2CH2O)nH
Color/Form: Neat
Melting point: 53 - 54°C
Formula: CH₃(OCH₂CH₂)nOH

MDL Number: MFCD00084416
CAS Number: 9004-74-4
Appearance (Form): Powder or crystals to flakes
Appearance (Colour): White to almost white to off white
Chemical State: Solid
Product Number: 81321
CAS Number: 9004-74-4
CAS: 9004-74-4
Molecular Formula: (C2H4O)nCH4O
Molecular Weight (g/mol): 76.10
MDL Number: MFCD00084416
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
PubChem CID: 8019
ChEBI: CHEBI:46790

IUPAC Name: 2-methoxyethan-1-ol
SMILES: COCCO
Melting Point: 53°C
Color: White
Physical Form: Crystalline Powder
Chemical Name or Material: Polyethylene Glycol Monomethyl Ether 2000
Molecular Formula/Molecular Weight: n/a
CAS No: 9004-74-4
Physical State: Solid
Color: White
Melting Point: 53°C
Condition to Avoid: n/a
Refractive Index: n/a
Specific Gravity: n/a
MDL No: MFCD00084416



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Poly(ethylene glycol) methyl ether 300 is a polyether compound with many applications in various industries, including pharmaceuticals, cosmetics, and food processing.
Poly(ethylene glycol) methyl ether 300s are polymers of ethylene oxide, and they are known for their water-soluble and biocompatible properties.
Poly(ethylene glycol) methyl ether 300 is a poly(ethylene glycol) compound having a methacrylate group at the alpha-terminus and a methyl group at the omega-terminus.

CAS Number: 26915-72-0
Molecular Formula: C13H24O6
Molecular Weight: 276.32606

Poly(ethylene glycol) methyl ether 300 is a hydrophilic polymer.
Poly(ethylene glycol) methyl ether 300 can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups.
When crosslinked into networks, Poly(ethylene glycol) methyl ether 300 can have high water content, forming "hydrogels".

Hydrogel formation can be initiated by either crosslinking Poly(ethylene glycol) methyl ether 300 by ionizing radiation or by covalent crosslinking of Poly(ethylene glycol) methyl ether 300 macromers with reactive chain ends.
Poly(ethylene glycol) methyl ether 300 is a suitable material for biological applications because it does not trigger an immune response.
Poly(ethylene glycol) methyl ether 300, often abbreviated as PEG 300, is a type of polyethylene glycol (PEG) derivative.

Poly(ethylene glycol) methyl ether 300 is a nonlinear analog of polyethylene glycol (PEG).
Poly(ethylene glycol) methyl ether 300 is a biocompatible homopolymer with a brush type structure that is mainly used to provide a PEG modified surface.
Poly(ethylene glycol) methyl ether 300 cross-linked polymeric materials (hydrogels) are suitable carriers for drug delivery and various other biomedical applications.

Poly(ethylene glycol) methyl ether 300 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers, to stabilize polymer emulsions, and in synthesis of comb polymers.
Poly(ethylene glycol) methyl ether 300 is a nonlinear analog of polyethylene glycol (PEG).
Poly(ethylene glycol) methyl ether 300 is a biocompatible homopolymer with a brush type structure that is mainly used to provide a PEG modified surface.

Poly(ethylene glycol) methyl ether 300 indicates the average molecular weight of the specific PEG at 400.PEG 3350 is a laxative.
Poly(ethylene glycol) methyl ether 300 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Poly(ethylene glycol) methyl ether 300 is a polyether compound with many applications from industrial manufacturing to medicine.

Poly(ethylene glycol) methyl ether 300 commonly referred to as PEG 300, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Due to its low toxicity, Poly(ethylene glycol) methyl ether 300 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 300 is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries.

Poly(ethylene glycol) methyl ether 300 serves as a kind of solubilizer, excipient, lubricant, and chemical reagent.
Poly(ethylene glycol) methyl ether 300 is a clear, colorless liquid that is made from sugar cane waste so it is naturally derived and renewable.
Poly(ethylene glycol) methyl ether 300 is completely soluble in water and has an average molecular weight of 288 - 311.

Poly(ethylene glycol) methyl ether 300 is another group of products with an incredibly long list of uses and applications from industrial uses to food and pharma, and everything in between.
Poly(ethylene glycol) methyl ether 300 is PEG-6-based plasticizer and mold release agent.
Poly(ethylene glycol) methyl ether 300 possesses lubricity and humectant properties.

Poly(ethylene glycol) methyl ether 300 maintains wet-tack strength.
Poly(ethylene glycol) methyl ether 300 is used in pressure sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 300 is a water-miscible polyether with an average molecular weight of 300 g/mol.

Poly(ethylene glycol) methyl ether 300 is a clear viscous liquid at room temperature with non-volatile, stable properties.
Poly(ethylene glycol) methyl ether 300is widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries.
Poly(ethylene glycol) methyl ether 300 with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.

These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Poly(ethylene glycol) methyl ether 300 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.

Poly(ethylene glycol) methyl ether 300 is soluble in water (mw 1,000) and many organic solvents.
Poly(ethylene glycol) methyl ether 300 molecules of approximately 2000 monomers.
Poly(ethylene glycol) methyl ether 300 is used in various applications from industrial chemistry to biological chemistry.

Recent research has shown Poly(ethylene glycol) methyl ether 300 maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.
They serve as solubilizers, excipients, lubricants, and chemical reagents.
Low molecular weight Poly(ethylene glycol) methyl ether 300s are observed to exhibit antibacterial properties as well.

Poly(ethylene glycol) methyl ether 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.
Poly(ethylene glycol) methyl ether 300 is a neutral and biocompatible hydrophilic polymer.
Poly(ethylene glycol) methyl ether 300 is usually used to modify therapeutic proteins and peptides to increase their solubility.

Poly(ethylene glycol) methyl ether 300 is used as a moisturizer, solubiliser in antiperspirant and deodorants, shampoos and liquid soap, hair styling products, bar soaps and oral care products as a stabilizer and wetting agent for drilling.
Poly(ethylene glycol) methyl ether 300 is a polymer which is hydrolyzed by ethylene oxide.
Poly(ethylene glycol) methyl ether 300 has no toxicity and irritation.

Poly(ethylene glycol) methyl ether 300 is widely used in various pharmaceutical preparations.
The toxicity of low molecular weight Poly(ethylene glycol) methyl ether 300 is relatively large.
In general, the toxicity of diols is very low.

Topical application of Poly(ethylene glycol) methyl ether 300, especially mucosal drug, can cause irritant pain.
In topical lotion, Poly(ethylene glycol) methyl ether 300 can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Poly(ethylene glycol) methyl ether 300 is a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.

Poly(ethylene glycol) methyl ether 300 cross-linked polymeric materials (hydrogels) are suitable carriers for drug delivery and various other biomedical applications.
Poly(ethylene glycol) methyl ether 300 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers, to stabilize polymer emulsions, and in synthesis of comb polymers.
Poly(ethylene glycol) methyl ether 300 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.

Poly(ethylene glycol) methyl ether 300 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
Poly(ethylene glycol) methyl ether 300 is a highly pure polymer of ethylene glycol with one methyl ether group.

Poly(ethylene glycol) methyl ether 300 has been used as multipurpose molecular tool for various chemical applications.
Poly(ethylene glycol) methyl ether 300 has also been used in a wide array of other biochemical and immunological applications.
Poly(ethylene glycol) methyl ether 300, a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.

Poly(ethylene glycol) methyl ether 300 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
Polyethylene glycol 300 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of Polyethylene glycol 300 is commonly expressed as H−(O−CH2−CH2)n−OH.

Poly(ethylene glycol) methyl ether 300 is one of the most commonly used chemical polyethers in manufacturing, medicine and many other applications.
Poly(ethylene glycol) methyl ether 300 is available in multiple forms for various uses.

The most common way of differentiating between Polyethylene glycol 300 is by molecular weight.
Poly(ethylene glycol) methyl ether 300 is used as a base for skin creams and other personal care products, as well as a solvent and viscosity modifier in soaps and detergents.

Melting point: 33-38 °C
Boiling point: 54 °C
Density: 1.1 g/mL at 25 °C
refractive index: n20/D 1.496
Flash point: >230 °F
storage temp.: -20°C
form: Granular Solid
color: White to off-white
Water Solubility: Soluble in water.

Poly(ethylene glycol) methyl ether 300 specifically refers to a PEG with an average molecular weight around 300 g/mol.
The "methyl ether" part of the name indicates that it has methyl groups attached to the ether oxygen atoms.
The presence of these groups can influence the properties and applications of the polymer.

Poly(ethylene glycol) methyl ether 300 and other PEG derivatives are commonly used in pharmaceuticals as excipients, solubilizing agents, and drug delivery carriers.
They are also utilized in various formulations to improve the solubility and bioavailability of certain drugs.
Additionally, Poly(ethylene glycol) methyl ether 300s are used in the preparation of cosmetics, as they are generally well-tolerated by the skin and have moisturizing properties.

Poly(ethylene glycol) methyl ether 300 is also used to process rubber, plastics and textiles, as an additive in lubricants and grease, and as a humectant, dye carrier and binder in paints and inks.
Poly(ethylene glycol) methyl ether 300 is colorless, almost odorless and tasteless liquid at room temperature.
Poly(ethylene glycol) methyl ether 300 is manufactured by alkali-catalysed polymerization of ethylene oxide with subsequent neutralization of the catalyst.

Poly(ethylene glycol) methyl ether 300 is sometimes used as a plasticizer and lubricant in various industries.
In plastics and rubber manufacturing, Poly(ethylene glycol) methyl ether 300 can enhance flexibility and reduce brittleness.
In pharmaceuticals, Poly(ethylene glycol) methyl ether 300 may serve as a lubricant in tablet formulations.

Poly(ethylene glycol) methyl ether 300s, including PEG 300, are generally stable under various environmental conditions.
This stability contributes to their suitability for use in a wide range of applications.
The physical properties of Poly(ethylene glycol) methyl ether 300s, such as viscosity and solubility, can be temperature-dependent.

Some formulations may take advantage of these temperature-dependent properties, especially in applications such as controlled drug release systems.
Poly(ethylene glycol) methyl ether 300 can be blended with other polymers to achieve specific properties in the resulting material.
Blending Poly(ethylene glycol) methyl ether 300 with other polymers can be a strategy to tailor the physical and chemical characteristics of the final product.

Compatibility with Other Ingredients: When formulating pharmaceuticals, cosmetics, or other products, compatibility with other ingredients is crucial.
Poly(ethylene glycol) methyl ether 300 is often chosen for its compatibility with a wide range of compounds, facilitating the creation of stable formulations.
Poly(ethylene glycol) methyl ether 300, there are other PEG derivatives with different molecular weights, such as PEG 400, PEG 600, etc.

The choice of a specific Poly(ethylene glycol) methyl ether 300 derivative depends on the requirements of a particular application.
Poly(ethylene glycol) methyl ether 300 is a subject of ongoing research and development to explore new applications and improve existing formulations.
Scientists and researchers continually investigate the properties of Poly(ethylene glycol) methyl ether 300s to expand their utility in various fields.

Poly(ethylene glycol) methyl ether 300 in pharmaceuticals and other products is subject to regulatory standards and guidelines.
Manufacturers must adhere to these regulations to ensure the safety and efficacy of the final product.
Poly(ethylene glycol) methyl ether 300 is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointment and suppository base, and tablet and capsule lubricant.

Poly(ethylene glycol) methyl ether 300 has low toxicity with systemic absorption less than 0.5%.
Poly(ethylene glycol) methyl ether 300 occurs when PEGs are attached to various protein medications, allowing for greater solubility for certain drugs.

Poly(ethylene glycol) methyl ether 300 is highly soluble in water and many organic solvents.
This solubility makes Poly(ethylene glycol) methyl ether 300 a versatile compound for use in various formulations.
Poly(ethylene glycol) methyl ether 300, are known to be hygroscopic, meaning they can absorb and retain water from their surroundings.

This property can be beneficial in formulations where moisture content is a consideration.
The viscosity of Poly(ethylene glycol) methyl ether 300 is relatively low, which makes it useful for applications where a low-viscosity liquid is desirable.
This property is advantageous in the pharmaceutical industry for formulating liquid dosage forms.

Poly(ethylene glycol) methyl ether 300s are generally considered biocompatible and are widely used in pharmaceuticals and medical applications.
Their use in drug formulations is often attributed to their ability to enhance the solubility of poorly soluble drugs and improve drug delivery.
Poly(ethylene glycol) methyl ether 300 is often employed in drug delivery systems, such as in the preparation of micelles, nanoparticles, and liposomes.

These drug delivery systems can improve the stability and bioavailability of certain drugs.
Poly(ethylene glycol) methyl ether 300 can be found in various personal care products, including creams, lotions, and ointments, where it functions as a humectant, helping to retain moisture in the skin.

The structure of Poly(ethylene glycol) methyl ether 300 consists of repeating ethylene glycol units, with methyl ether groups attached to the oxygen atoms.
Poly(ethylene glycol) methyl ether 300 structure contributes to its physical and chemical properties.

Uses:
Poly(ethylene glycol) methyl ether 300, is used as Emulsion polymers, cosmetics, construction, emulsifiers.
Poly(ethylene glycol) methyl ether 300 is used in a number of toothpastes as a dispersant.
In this application, Poly(ethylene glycol) methyl ether 300 binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.

Poly(ethylene glycol) methyl ether 300 is also under investigation for use in body armor, and in tattoos to monitor diabetes.
Polymer segments derived from Poly(ethylene glycol) methyl ether 300 polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
In low-molecular-weight formulations (e.g. PEG 400), Poly(ethylene glycol) methyl ether 300 is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.

Poly(ethylene glycol) methyl ether 300 is also used as an anti-foaming agent in food and drinks.
Poly(ethylene glycol) methyl ether 300 is often used as a solubilizing agent to enhance the solubility of poorly soluble drugs.
This is particularly important in the formulation of oral and injectable medications.

Poly(ethylene glycol) methyl ether 300 is employed as an excipient in pharmaceutical formulations, contributing to the stability and bioavailability of drugs.
Poly(ethylene glycol) methyl ether 300 is used in the development of drug delivery systems such as micelles, liposomes, and nanoparticles, aiding in controlled drug release.
Poly(ethylene glycol) methyl ether 300 functions as an emollient in cosmetic products, helping to soften and moisturize the skin.

Poly(ethylene glycol) methyl ether 300 is hygroscopic properties make it useful as a humectant, retaining moisture in cosmetic formulations.
Poly(ethylene glycol) methyl ether 300 may be used as a carrier for active ingredients in cosmetic products.
Poly(ethylene glycol) methyl ether 300 acts as a plasticizer, improving the flexibility and durability of plastics and rubber products.

Poly(ethylene glycol) methyl ether 300 can be used as an emulsifying agent in food products, assisting in the dispersion of oil and water phases.
Poly(ethylene glycol) methyl ether 300 may contribute to the stability of certain food formulations.
Poly(ethylene glycol) methyl ether 300 is used as a lubricant in various processes, including tablet manufacturing in the pharmaceutical industry.

Poly(ethylene glycol) methyl ether 300 serves as an intermediate in the synthesis of other chemicals and polymers.
Poly(ethylene glycol) methyl ether 300 is utilized as a reagent in laboratory experiments and research studies.
Poly(ethylene glycol) methyl ether 300 can be blended with other polymers to achieve specific properties in the resulting material.

Poly(ethylene glycol) methyl ether 300 may be used as a softening agent in textile processing.
Poly(ethylene glycol) methyl ether 300 can be used as a plasticizing agent in the formulation of adhesives and sealants.
Poly(ethylene glycol) methyl ether 300 may be used in the preparation of a polyelectrolytic solution for the development of lithium ion batteries.

Poly(ethylene glycol) methyl ether 300 can be photopolymerized to form a zwitterionic monomer which can be coated on steel surfaces for bio-fouling based applications.
An example study was done using PEG-diacrylate hydrogels to recreate vascular environments with the encapsulation of endothelial cells and macrophages.
This model furthered vascular disease modeling and isolated macrophage phenotype's effect on blood vessels.

Poly(ethylene glycol) methyl ether 300 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Although polyethylene glycol is considered biologically inert, it can form non-covalent complexes with monovalent cations such as Na+, K+, Rb+, and Cs+, affecting equilibrium constants of biochemical reactions.
Poly(ethylene glycol) methyl ether 300 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.

X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
Poly(ethylene glycol) methyl ether 300 is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.
In microbiology, Poly(ethylene glycol) methyl ether 300 precipitation is used to concentrate viruses.

Poly(ethylene glycol) methyl ether 300 is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.
Poly(ethylene glycol) methyl ether 300-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.
The size of the Poly(ethylene glycol) methyl ether 300 polymer has been shown to be important, with larger polymers achieving the best immune protection.

Poly(ethylene glycol) methyl ether 300 is a component of stable nucleic acid lipid particles (SNALPs) used to package siRNA for use in vivo.
In blood banking, Poly(ethylene glycol) methyl ether 300 is used as a potentiator to enhance detection of antigens and antibodies.
When working with phenol in a laboratory situation, Poly(ethylene glycol) methyl ether 300 can be used on phenol skin burns to deactivate any residual phenol.

In biophysics, polyethylene glycols are the molecules of choice for the functioning ion channels diameter studies, because in aqueous solutions they have a spherical shape and can block ion channel conductance.
Poly(ethylene glycol) methyl ether 300 can be used in the development of molecular brushes as a substrate material for stimuli-responsive surfaces in biomedical applications.
Poly(ethylene glycol) methyl ether 300 may be used in the surface modification of poly(ether sulfone) based ultrafiltration (UF) membrane as a foul-resistant material.

Poly(ethylene glycol) methyl ether 300 is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
Poly(ethylene glycol) methyl ether 300 is the basis of a number of laxatives (as MiraLax, RestoraLAX, etc.).
Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy or for children with constipation.

Macrogol (with brand names such as Laxido, GoLytely and Miralax) is the generic name for Poly(ethylene glycol) methyl ether 300 used as a laxative.
The name may be followed by a number which represents the average molecular weight (e.g. macrogol 3350, macrogol 4000 or macrogol 6000).
The possibility that Poly(ethylene glycol) methyl ether 300 could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.

An example of Poly(ethylene glycol) methyl ether 300 hydrogels (see Biological uses section) in a therapeutic has been theorized by Ma et al.
They propose using the hydrogel to address periodontitis (gum disease) by encapsulating stem cells in the gel that promote healing in the gums.
The gel with encapsulated stem cells was to be injected into the site of disease and crosslinked to create the microenvironment required for the stem cells to function.

Poly(ethylene glycol) methyl ether 300 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Poly(ethylene glycol) methyl ether 300 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
Poly(ethylene glycol) methyl ether 300 is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.

Poly(ethylene glycol) methyl ether 300 segments derived from PEG polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
In microbiology, Poly(ethylene glycol) methyl ether 300 precipitation is used to concentrate viruses.
Poly(ethylene glycol) methyl ether 300 is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.

Gene therapy vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.
The size of the Poly(ethylene glycol) methyl ether 300 polymer has been shown to be important, with larger polymers achieving the best immune protection.
Poly(ethylene glycol) methyl ether 300 is a component of stable nucleic acid lipid particles used to package siRNA for use in vivo.

In blood banking, Poly(ethylene glycol) methyl ether 300 is used as a potentiator to enhance detection of antigens and antibodies.
Poly(ethylene glycol) methyl ether 300of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity.
Poly(ethylene glycol) methyl ether 300 lipid is used as an excipient in both the Moderna and Pfizer–BioNTech vaccines for SARS-CoV-2.

Both RNA vaccines consist of messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids.
Proprietary lipid technology is used for each.
In both vaccines, the bubbles are coated with a stabilizing molecule of Poly(ethylene glycol) methyl ether 300.

As of December 2020 there is some concern that Poly(ethylene glycol) methyl ether 300 could trigger allergic reaction, and in fact allergic reactions are the driver for both the United Kingdom and Canadian regulators to issue an advisory, noting that: two "individuals in the U.K.
As of 18 December, the US CDC stated that in their jurisdiction six cases of "severe allergic reaction" had been recorded from more than 250,000 vaccinations, and of those six only one person had a "history of vaccination reactions".

Poly(ethylene glycol) methyl ether 300 has a low toxicity and is used in a variety of products.
Poly(ethylene glycol) methyl ether 300 is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments.
Since Poly(ethylene glycol) methyl ether 300 is a flexible, water-soluble polymer, it can be used to create very high osmotic pressures (on the order of tens of atmospheres).

Poly(ethylene glycol) methyl ether 300 also is unlikely to have specific interactions with biological chemicals.
These properties make Poly(ethylene glycol) methyl ether 300 one of the most useful molecules for applying osmotic pressure in biochemistry and biomembranes experiments, in particular when using the osmotic stress technique.
Poly(ethylene glycol) methyl ether 300 is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.

Poly(ethylene glycol) methyl ether 300 replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.
In addition, Poly(ethylene glycol) methyl ether 300 is used when working with green wood as a stabilizer, and to prevent shrinkage.
Poly(ethylene glycol) methyl ether 300 has been used to preserve the painted colors.

These painted artifacts were created during.
Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry.
Poly(ethylene glycol) methyl ether 300 is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.

Poly(ethylene glycol) methyl ether 300 is frequently used to preserve waterlogged wood and other organic artifacts that have been salvaged from underwater archaeological contexts, as was the case with the warship Vasa in Stockholm, and similar cases.
Poly(ethylene glycol) methyl ether 300 replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.
In addition, Poly(ethylene glycol) methyl ether 300 is used when working with green wood as a stabilizer, and to prevent shrinkage.

Poly(ethylene glycol) methyl ether 300 has been used to preserve the painted colors on Terracotta Warriors unearthed at a UNESCO World Heritage site in China.
These painted artifacts were created during the Qin Shi Huang (first emperor of China) era.
Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry Xi'an air.

The paint would subsequently flake off in about four minutes.
The German Bavarian State Conservation Office developed a Poly(ethylene glycol) methyl ether 300 preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay soldiers.
Poly(ethylene glycol) methyl ether 300 is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.

Poly(ethylene glycol) methyl ether 300 derivatives, such as narrow range ethoxylates, are used as surfactants.
Poly(ethylene glycol) methyl ether 300 has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
Poly(ethylene glycol) methyl ether 300 is a component of the propellent used in UGM-133M Trident II Missiles, in service with the United States Navy.

Poly(ethylene glycol) methyl ether 300 has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.
Poly(ethylene glycol) methyl ether 300 is also used as a polymer host for solid polymer electrolytes.
Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving Poly(ethylene glycol) methyl ether 300, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.

Poly(ethylene glycol) methyl ether 300 is injected into industrial processes to reduce foaming in separation equipment.
Poly(ethylene glycol) methyl ether 300 is used as a binder in the preparation of technical ceramics.
Poly(ethylene glycol) methyl ether 300 was used as an additive to silver halide photographic emulsions.

Poly(ethylene glycol) methyl ether 300 is used in a number of toothpastes[5] as a dispersant.
In this application, Poly(ethylene glycol) methyl ether 300 binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
Poly(ethylene glycol) methyl ether 300 is also under investigation for use in body armor, and in tattoos to monitor diabetes.

In low-molecular-weight formulations (e.g. PEG 400), Polyethylene glycol 300 is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.
Poly(ethylene glycol) methyl ether 300 is also used as an anti-foaming agent in food and drinks.

Safety Profile:
Poly(ethylene glycol) methyl ether 300 may cause irritation to the skin and eyes, especially in concentrated or pure form.
Prolonged or repeated contact with the skin should be avoided.
Inhalation of vapor or mist may cause respiratory irritation.

Adequate ventilation should be maintained in areas where Poly(ethylene glycol) methyl ether 300 is used, and exposure to airborne particles should be minimized.
Poly(ethylene glycol) methyl ether 300 is generally not expected to cause significant harm, but it is not intended for consumption.
Accidental ingestion may lead to gastrointestinal discomfort.

Synonyms:
PEG-6 dimethyl ether
Genosorb 300
Carpol CLE 1000
Dimethoxy polyethylene glycol
Genosorb 175
Glycols, polyethylene, dimethyl ether
Glyme-23
Nissan Unisafe MM 1000
Nissan Unisafe MM 400
O5E08Z8AEA
PEG-6 DME
PEG-DME 2000
POLY(ETHYLENE GLYCOL) DIMETHYL ETHER (300 MW)
POLYGLYCOL DME 300
POLYGLYME-6
Polyoxyethylene dimethyl ether
Sanfine DM 1000
Sanfine DM 200
Sanfine DM 400
Selexol
U-Nox DM 1000
U-Nox DM 200
UNII-7GSD980LF9
UNII-9I2Z48JZJ5
UNII-O5E08Z8AEA
UNII-OMW34MPM4E
UNII-W83S1I1CJE
Varonic DM 55
alpha,omega-Methoxypoly(ethylene oxide)
alpha-Methyl-omega-methoxypoly(oxy-1,2-ethanediyl)

Poly(ethylene glycol) methyl ether 3000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 3000 maintains wet-tack strength and possesses lubricity and humectant properties.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2



Poly(ethylene glycol) methyl ether 3000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 3000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 3000 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 3000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 3000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 3000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 3000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 3000 is Powder.
Poly(ethylene glycol) methyl ether 3000, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 3000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 3000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 3000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 3000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 3000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 3000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 3000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 3000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 3000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 3000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 3000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 3000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 3000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 3000 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
Poly(ethylene glycol) methyl ether 3000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 3000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 3000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 3000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 3000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 3000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 3000 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 3000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 3000 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 3000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 3000 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 3000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 3000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 3000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 3000 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 3000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 3000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 3000 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 3000 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 3000 is available in powder form.


Poly(ethylene glycol) methyl ether 3000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 3000 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 3000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 3000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 3000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 3000 is used for formulating screens or for optimization.
Crystallization grade Poly(ethylene glycol) methyl ether 3000 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 3000 is a hydrophilic polymer that is used to control the flexibility of a composite.


Poly(ethylene glycol) methyl ether 3000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.
Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 3000.
Poly(ethylene glycol) methyl ether 3000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Poly(ethylene glycol) methyl ether 3000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 3000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 3000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 3000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 3000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
Poly(ethylene glycol) methyl ether 3000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
Physical state: pellets, flakes
Color: colorless
Odor: No data available
Melting point/range: 20 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 182 °C (closed cup)
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity:
Kinematic viscosity: No data available
Dynamic viscosity: No data available
Water solubility at 20 °C: Slightly soluble
Partition coefficient (n-octanol/water): No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Physical Form of Poly(ethylene glycol) methyl ether 350 is Powder.
Poly(ethylene glycol) methyl ether 350, with an average molecular weight of 350, is widely used in various industries.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 350, Methoxypolyethylene glycol, Methoxypolyethylene glycol 350, Methoxypolyethylene glycol, Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 350, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em, Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, MARLIPAL 1/7, METHOXY PEG-7, METHOXY PEG-7 [INCI], METHOXYPOLYETHYLENE GLYCOL 350, METHOXYPOLYOXYETHYLENE GLYCOL 350, MPEG 350, MPEG-7, PEG-7 METHYL ETHER, PEG-7 METHYL ETHER [II], PEG-7 METHYL ETHER [INCI], POLYETHYLENE GLYCOL (7) METHYL ETHER, POLYETHYLENE GLYCOL 350 METHYL ETHER, POLYXOYETHYLENE (7) METHYL ETHER, 9004-74-4, MARLIPAL 1/7, METHOXY PEG-7, METHOXY PEG-7 [INCI], METHOXYPOLYETHYLENE GLYCOL 350, METHOXYPOLYOXYETHYLENE GLYCOL 350, MPEG 350, MPEG-7, PEG-7 METHYL ETHER, PEG-7 METHYL ETHER [II], PEG-7 METHYL ETHER [INCI], POLYETHYLENE GLYCOL (7) METHYL ETHER, POLYETHYLENE GLYCOL 350 METHYL ETHER, POLYXOYETHYLENE (7) METHYL ETHER,



Poly(ethylene glycol) methyl ether 350 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 350 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 350 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 350 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 350 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 350 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 350 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 350 is Powder.
Poly(ethylene glycol) methyl ether 350, with an average molecular weight of 350, is widely used in various industries.


Poly(ethylene glycol) methyl ether 350is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 350 has a range of potential uses.


Poly(ethylene glycol) methyl ether 350, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 350 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 350 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 350 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 350 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 350, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 350 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 350 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 350, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 350, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 350, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 350 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
Poly(ethylene glycol) methyl ether 350 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 350 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 350 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 350 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 350 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 350 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 350 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 350 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 350 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 350 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 350 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 350 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 350 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 350 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 350 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 350 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 350 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 350 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 350 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 350 is available in powder form.


Poly(ethylene glycol) methyl ether 350 is used as a solvent, excipient, surfactant and dispersing agent.
Crystallization grade Poly(ethylene glycol) methyl ether 350 is used for formulating screens or for optimization


Poly(ethylene glycol) methyl ether 350 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 350 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 350 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.


Poly(ethylene glycol) methyl ether 350 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
Crystallization grade Poly(ethylene glycol) methyl ether 350 is used for formulating screens or for optimization.


Poly(ethylene glycol) methyl ether 350 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 350 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 350.
Poly(ethylene glycol) methyl ether 350, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Poly(ethylene glycol) methyl ether 350 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 350 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 350 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 350's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 350's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
Poly(ethylene glycol) methyl ether 350 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
Category: Detergents, Anionic detergents
Appearance: Liquid, Colourless
pH: 4.5-7.5
Hydroxyl Value: 152-168
Physical State: Liquid
Solubility: Soluble in water (partly)
Storage: Store at room temperature
Melting Point: 52-56°C
Density: 1.09 g/mL
Refractive Index: n20D 1.46
CAS Number: 9004-74-4
Molecular Formula: (C2H4O)nCH4O
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N

SMILES: COCCO
MDL Number: MFCD00084416
Molecular Weight: 325 to 375 D
Residual Water: 0.5% max
Physical state: Paste
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 64 - 69 °C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182 °C
Autoignition temperature: Not available

Decomposition temperature: Not available
pH: Not available
Viscosity: Kinematic viscosity: Not available, Dynamic viscosity: Not available
Water solubility: Not available
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: Not available
Other safety information: Not available
Formula: CH₃(OCH₂CH₂)nOH

Density: 1.09
Flash Point: >110 °C (230 °F)
Storage Temperature: Ambient
MDL Number: MFCD00084416
CAS Number: 9004-74-4
CAS Registration Number: 9004-74-4
Unique Ingredient Identifier: ENK4Y6S66X
Molecular Formula: CH3(OCH2CH2)nOH
CAS Number: 9004-74-4
Molecular Weight: 76.09
HS Code: 39072090
pH: 4.0 to 8.0 (1% aqueous solution)
Physical Form: Liquid
Linear Formula: CH3(OCH2CH)nOH

Density: 1.09 g/mL
Quantity: 500 g
Hydroxyl Value: 152 to 168 mg KOH/g
Infrared Spectrum: Authentic
Refractive Index: 1.4560 to 1.4580 (20°C, 589 nm)
Water: 0.15% max. (Karl Fischer method)
Chemical Name or Material: Poly(ethylene glycol methylether), Average M.W. 350
CAS Number: 9004-74-4
Category: Polymer/Macromolecule
Molecular Weight: 350
Boiling Point: >200°C (decomposes)

Melting Point: -8°C
Flash Point: 360°F
Density: 1.091 (20°C)
Alpha Sort: Polyethylene glycol monomethyl ether
Viscosity: 4.1 cSt (99°C)
CAS Registry Number: 9004-74-4
Classification: POLYETHERS
Formula: CH3O + (C2H4O)n + H
Instrument Name: Bio-Rad FTS 175C with Raman accessory
Molecular Weight (Average): 350



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 400 has a range of potential uses.
Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 400, Methoxypolyethylene glycol, Methoxypolyethylene glycol 400 methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em, Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2



Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 400 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 400 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 400 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 400 is used in pressure-sensitive and thermoplastic adhesives.


Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.
Physical Form of Poly(ethylene glycol) methyl ether 400 is Powder.
Poly(ethylene glycol) methyl ether 400, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 400is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 400 has a range of potential uses.


Poly(ethylene glycol) methyl ether 400, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 400 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 400 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 400 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 400 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 400, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 400 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 400 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 400, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 400, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 400, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 400 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
Poly(ethylene glycol) methyl ether 400 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) methyl ether 400 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 400 is intended for laboratory use only, and it is not meant for human consumption.
Poly(ethylene glycol) methyl ether 400 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 400 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.
Poly(ethylene glycol) methyl ether 400 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.


In addition, Poly(ethylene glycol) methyl ether 400 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.
Poly(ethylene glycol) methyl ether 400 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.


Moreover, Poly(ethylene glycol) methyl ether 400 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.
Poly(ethylene glycol) methyl ether 400 is used as enteric release coatings.


Poly(ethylene glycol) methyl ether 400 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 400 acts as a solvent for brake fluids.
Further, Poly(ethylene glycol) methyl ether 400 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.


In addition to this, Poly(ethylene glycol) methyl ether 400 is used in surfactants, polyester and polyurethane based paints.
Poly(ethylene glycol) methyl ether 400 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 400 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 400 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 400 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 400 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 400 is available in powder form.


Poly(ethylene glycol) methyl ether 400 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 400 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 400 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 400 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 400 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 400 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 400 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 400 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 400.
Poly(ethylene glycol) methyl ether 400, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400 :
*Poly(ethylene glycol) methyl ether 400 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 400 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 400 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 400's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 400's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
Poly(ethylene glycol) methyl ether 400 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
Categories: Detergents, Anionic detergents
Appearance: Colorless liquid
pH: 4.5-7.5
Refractive Index: 1.46
Hydroxyl Value: 130-150
Physical State (20°C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN: 9004-74-4
PubChem Substance ID: 253662344
MDL Number: MFCD00084416
Chemical Name or Material: Polyethylene Glycol Monomethyl Ether 400
Color: Yellow

Synonym: methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether,
methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol,
3-oxa-1-butanol, egme, monomethyl glycol, dowanol em
SMILES: COCCO
Molecular Weight (g/mol): 76.10
ChEBI: CHEBI:46790
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
IUPAC Name: 2-methoxyethan-1-ol
PubChem CID: 8019
Average molecular weight: 380 to 420
Melting Point: n/a
Specific Gravity: 1.09
Physical state: Pellets, flakes

Color: Colorless
Odor: No data available
Melting point/freezing point: Melting point/range: 20°C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 182°C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity: Viscosity, kinematic: No data available; Viscosity, dynamic: No data available

Water solubility at 20°C: Slightly soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 5000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 5000 maintains wet-tack strength and possesses lubricity and humectant properties.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, Methoxypolyethylene glycols, METHOXY POLYETHYLENE GLYCOL 750, Poly(ethylene glycol methyl ether), Poly(ethylene glycol) methyl ether, ETHYLENE GLYCOL 750 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 550 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 350 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 1900 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 5000 MONOMETHYL ETHER POLYMER, 2-ethanediyl), alpha.-methyl.-omega.-hydroxy-Poly(oxy-1, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether



Poly(ethylene glycol) methyl ether 5000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 5000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 5000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 5000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 5000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.
Poly(ethylene glycol) methyl ether 5000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.


Poly(ethylene glycol) methyl ether 5000 offers ample flexibility with availability in bulk and pre-packs.
Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 5000 is PEG-6 methyl ether-based plasticizer.


Poly(ethylene glycol) methyl ether 5000 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 5000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 5000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 5000 is Powder.


Poly(ethylene glycol) methyl ether 5000, with an average molecular weight of 750, is widely used in various industries.
Poly(ethylene glycol) methyl ether 5000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 5000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 5000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 5000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 5000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 5000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 5000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
Crystallization grade Poly(ethylene glycol) methyl ether 5000 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 5000 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 5000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 5000.
Poly(ethylene glycol) methyl ether 5000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.


Poly(ethylene glycol) methyl ether 5000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 5000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 5000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 5000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 5000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 5000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 5000 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 5000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 5000 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 5000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.


In addition to this, Poly(ethylene glycol) methyl ether 5000 is used in surfactants, polyester and polyurethane based paints.
Poly(ethylene glycol) methyl ether 5000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 5000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) methyl ether 5000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 5000 is intended for laboratory use only, and it is not meant for human consumption.
Poly(ethylene glycol) methyl ether 5000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 5000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.


Poly(ethylene glycol) methyl ether 5000 is a versatile compound commonly used in various applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 5000 has a range of potential uses.


With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 5000 is available in powder form.
Poly(ethylene glycol) methyl ether 5000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 5000 is also used as a wetting agent and viscosity modifier.


Poly(ethylene glycol) methyl ether 5000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.
Due to its low toxicity Poly(ethylene glycol) methyl ether 5000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.


Poly(ethylene glycol) methyl ether 5000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
Crystallization grade Poly(ethylene glycol) methyl ether 5000 is used for formulating screens or for optimization.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Poly(ethylene glycol) methyl ether 5000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 5000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 5000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 5000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 5000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
Poly(ethylene glycol) methyl ether 5000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
Physical state: Pellets, flakes
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 20 °C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182 °C - closed cup
Autoignition temperature: Not available
Decomposition temperature: Not available
pH: Not available
Viscosity:
Kinematic: Not available,
Dynamic: Not available

Water solubility at 20 °C: Slightly soluble
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available
Poly(ethylene glycol) methyl ether 5000
Catalog number: B2010415
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 g
Molecular Weight or Concentration: average Mn 5,000
Supplied as: Flakes/crystals
Appearance: White

Ω-end hydroxyl
α-end methoxy
Form: Powder or crystals, flakes
InChI key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
InChI: 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
Mol wt: Average Mn 5,000
MP: 60-64 °C
Vapor density: >1 (vs air)
Vapor pressure: 0.05 mmHg ( 20 °C)
CAS Number: 9004-74-4
CAS: 9004-74-4
EINECS: 618-394-3
InChI: InChI=1/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
Molecular Formula: C5H12O3
Molar Mass: 120.14698

Density: 1.094g/mL at 25°C
Melting Point: 60-64°C
Boiling Point: >200°C/760mmHg
Flash Point: 268 °C
Water Solubility: Slightly miscible with water.
Solubility: H2O: 50mg/mL at 25°C, clear, colorless
Vapor Pressure: 0.05 mm Hg ( 20 °C)
Vapor Density: >1 (vs air)
Appearance: White crystal
Specific Gravity: 1.094
Color: White to pale yellow
Maximum wavelength(λmax): ['λ: 260 nm Amax: 0.06', 'λ: 280 nm Amax: 0.03']
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Storage Condition: -20°C
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
Sensitive: Easily absorbing moisture
Refractive Index: n20/D 1.459
MDL: MFCD00084416



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Poly(ethylene glycol) methyl ether 750 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, mPEG thiol, Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG, Methoxypolyethylene glycol, Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 500,



Physical Form of Poly(ethylene glycol) methyl ether 750 is Powder.
Poly(ethylene glycol) methyl ether 750, with an average molecular weight of 750, is widely used in various industries.
Poly(ethylene glycol) methyl ether 750is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 750 has a range of potential uses.
Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 750 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 750 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 750 is used in pressure-sensitive and thermoplastic adhesives.


Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 750 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


Poly(ethylene glycol) methyl ether 750, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 750 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 750 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 750 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 750 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 750, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 750 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 750 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 750, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 750, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 750, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 750 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
Poly(ethylene glycol) methyl ether 750 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 750 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 750 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 750 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 750 is available in powder form.


Poly(ethylene glycol) methyl ether 750 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 750 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 750 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Poly(ethylene glycol) methyl ether 750 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 750 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 750 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 750 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 750 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 750 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 750 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 750 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 750 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 750 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 750 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 750 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 750 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 750 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 750 is intended for laboratory use only, and it is not meant for human consumption.


Due to its low toxicity Poly(ethylene glycol) methyl ether 750 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 750 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 750 is used for formulating screens or for optimization.
Crystallization grade Poly(ethylene glycol) methyl ether 750 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 750 is a hydrophilic polymer that is used to control the flexibility of a composite.


Poly(ethylene glycol) methyl ether 750 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.
Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 750.
Poly(ethylene glycol) methyl ether 750, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750 :
*Poly(ethylene glycol) methyl ether 750 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 750 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750 :
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 750 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 750's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 750's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
Poly(ethylene glycol) methyl ether 750 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
CAS: 9004-74-4
Molecular Formula: (C2H4O)nCH4O
Molecular Weight (g/mol): 76.10
MDL Number: MFCD00084416
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
PubChem CID: 8019
ChEBI: CHEBI:46790
SMILES: COCCO
Specification Sheet:
Residual water: 3% max
Molecular Weight: 715 to 785
pH: 4.5 to 7.5 (5% aq. soln., 25°C)
Form: Fused mass/clear liquid as a melt

Melting Point: 28–32°C
Density: 1.10
Flash Point: >110°C (230°F)
Storage Temperature: Ambient
Physical Properties:
Color: Colorless to Yellow
Physical Form: Low Melting Solid
Melting Point: 28°C to 32°C
Density: 1.10 g/mL
Solubility: Slightly miscible with water
Chemical Name or Material: Polyethylene glycol monomethylether, 750
Additional Information:

Ω-end: hydroxyl
α-end: methoxy
Molecular Weight: average Mn 750
Refractive Index: n20/D 1.459
Transition Temperature: Tm 30°C
Vapor Density: >1 (vs air)
Vapor Pressure: 0.05 mmHg (20°C)
Viscosity: 10.5 cSt (210°F) (lit.)
Physical State: Pellets, flakes
Flash Point: 182°C - closed cup
Oxidizing Properties: None
Other Safety Information: No data available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

Poly(ethylene glycol) monomethyl ether is a PEG linker containing a hydroxyl group.
The Poly(ethylene glycol) monomethyl ether enables further derivatization or replacement with other reactive functional groups.
The Poly(ethylene glycol) monomethyl ether spacer increases solubility in aqueous media.

CAS Number: 9004-74-4
Molecular Formula: C5H12O3
Molecular Weight: 120.14698
EINECS Number: 618-394-3

Poly(ethylene glycol) monomethyl ether is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) monomethyl ether chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) monomethyl ether can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

Poly(ethylene glycol) monomethyl ether, also known as PEG Monomethyl Ether, is a type of polyethylene glycol (PEG) derivative.
Poly(ethylene glycol) monomethyl ethers are polymers that are widely used in various industries for their solubility, stability, and ability to modify the physical properties of substances.
Poly(ethylene glycol) monomethyl ether specifically refers to PEG molecules with a single methyl (CH3) group attached to one end of the polymer chain.

Poly(ethylene glycol) monomethyl ether can be used as a pore-forming agent to prepare polysulfone membranes with enhanced hydrophilicity.
Poly(ethylene glycol) methyl ether-grafted polyamidoamine (PAMAM) dendrimers can be used as drug carrier systems for anticancer drugs.
Poly(ethylene glycol) monomethyl ether is the main material to produce polycarboxylate high water reducing agent.

Poly(ethylene glycol) monomethyl ether effective cement Good water solubility, wettability, lubricity, physiologically inert properties, irritability.
Poly(ethylene glycol) monomethyl etherwith medium properties is widely used in the cosmetic and pharmaceutical industries.
Poly(ethylene glycol) monomethyl ether are a series of methyl substituted poly(ethylene) glycols that have been used with some success in the crystallization of a number of hydrophobic proteins.

Poly(ethylene glycol) monomethyl ether cellosolve is an organic compound with the formula C3H8O2 used.
Poly(ethylene glycol) monomethyl ether is a clear, colorless liquid with an ether-like odor.
Poly(ethylene glycol) monomethyl ether is in a class of solvents known as glycol ethers, noted for their ability to dissolve a variety of substances.

Different types of chemical compounds have miscibility with water and other solvents.
Poly(ethylene glycol) monomethyl ether can be formed by nucleophilic attack of methanol on protonated ethylene oxide followed by proton.
Poly(ethylene glycol) monomethyl ether is used as a solvent for many different purposes such as varnishes, paints and resins.

Poly(ethylene glycol) monomethyl ether is also used as an additive in aircraft defrosting solutions.
Poly(ethylene glycol) monomethyl ether is widely used for the synthesis of Vaska complex and related compounds.
Poly(ethylene glycol) monomethyl ether is toxic to bone marrow and testicles.

Those exposed to high levels are at risk for granulocytopenia, macrocytic anemia, oligospermia and azoospermia.
Poly(ethylene glycol) monomethyl ether is converted to methoxyacetic acid (methoxyacetic acid) by alcohol dehydrogenase.
Poly(ethylene glycol) monomethyl ether ethanol and acetate have a protective effect.

Poly(ethylene glycol) monomethyl ether can enter the Krebs cycle where Polyethylene Glycol is present.
Poly(ethylene glycol) monomethyl ether is a group of solvents based on alkyl ethylene glycol or propylene glycol ethers commonly used in paints and cleaners.
Typically, low molecular weight ethers have a higher boiling point with favorable solvent properties.

Typically Poly(ethylene glycol) monomethyl ether is found as: pharmaceutical, sunscreens, cosmetics, inks, paints and water-based paints, Polyethylene Glycol Monomethyl Ether is used in degreasers, cleaners, aerosol paints and adhesives.
Poly(ethylene glycol) monomethyl ether comes in various molecular weights, which refers to the size of the polymer chain.
Different molecular weights of Poly(ethylene glycol) monomethyl ether can have slightly different properties and applications.

The specific molecular weight chosen can impact factors like solubility, viscosity, and compatibility with other substances.
In addition to the pharmaceutical uses mentioned earlier, Poly(ethylene glycol) monomethyl ether and other PEG derivatives are employed in medical and healthcare settings.
Certain Poly(ethylene glycol) monomethyl ether derivatives are used in medical imaging techniques like magnetic resonance imaging (MRI) and computed tomography (CT) scans to enhance contrast and improve visualization of certain tissues.

Poly(ethylene glycol) monomethyl ether, the process of attaching PEG molecules to drugs or drug carriers, can alter the pharmacokinetics of drugs, extending their circulation time in the body and potentially reducing immunogenicity.
Poly(ethylene glycol) monomethyl ether can have various derivatives, such as those modified with different functional groups or chain lengths.
These derivatives can exhibit specific properties suited to particular applications.

Poly(ethylene glycol) monomethyl ether is used to improve the solubility of poorly water-soluble drugs, enhancing their bioavailability and effectiveness.
Poly(ethylene glycol) monomethyl ether's incorporated into drug delivery systems to modify the release profile of drugs, enabling controlled and sustained drug delivery.
Poly(ethylene glycol) monomethyl ether Monomethyl Ether provides moisturization and smoothness to the skin, making it a popular ingredient in lotions, creams, and moisturizers.

Poly(ethylene glycol) monomethyl ether's used as an emulsifier in cosmetic formulations, helping blend water and oil-based ingredients.
Poly(ethylene glycol) monomethyl ether is sometimes employed to functionalize nanoparticles and improve their biocompatibility and stability.
Poly(ethylene glycol) monomethyl ether can also help nanoparticles evade the immune system, making them more suitable for medical applications like targeted drug delivery.

Poly(ethylene glycol) monomethyl ether, play a role in the development of biomaterials for tissue engineering, wound healing, and regenerative medicine.
Their water solubility, non-reactive nature, and ability to modify surface properties make them valuable in these contexts.
Research is ongoing to develop biodegradable and environmentally friendly alternatives to certain Poly(ethylene glycol) monomethyl ether derivatives, addressing concerns about persistence and accumulation in the environment.

Regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) oversee the safety and approval of Poly(ethylene glycol) monomethyl ether derivatives used in pharmaceuticals and other applications.
These agencies assess factors like toxicity, stability, and potential allergic reactions.

Melting point: 60-64 °C
Boiling point: >200°C/760mmHg
Density: 1.094 g/mL at 25 °C
vapor density: >1 (vs air)
vapor pressure: 0.05 mm Hg ( 20 °C)
refractive index: n20/D 1.459
Flash point: 268 °C
storage temp.: -20°C
solubility: H2O: 50 mg/mL at 25 °C, clear, colorless
form: semisolid
Specific Gravity: 1.094
color: White to pale yellow
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility: Slightly miscible with water.
λmax: λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.03
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
LogP: -0.800 (est)

Poly(ethylene glycol) monomethyl ether can be used as intermediates undergoing further chemical reactions.
The basic physicochemical properties of Poly(ethylene glycol) monomethyl ether were determined over a wide temperature range.
The impact of the introduction of brake fluids on key quality indices was studied on Poly(ethylene glycol) monomethyl ether borates.

Advances in electronics and life sciences have sparked interest in "lab-on-a-chip" systems that use complementary metals.
Poly(ethylene glycol) monomethyl ether polymer brushes are used as biointerface coatings to enhance their relevance in biosensing.
Using the surface-initiated "grafting" strategy, Poly(ethylene glycol) monomethyl ether films were reliably grown on each surface.

These Poly(ethylene glycol) monomethyl ether films were also studied to determine the potential impact on the environment.
Electronic devices providing information about the relative permeability and fault area for Poly(ethylene glycol) monomethyl ether are available in both dry and aqueous form.
Poly(ethylene glycol) monomethyl ether was shown that the addition of Polyethylene Glycol Monomethyl Ether coatings significantly reduced nonspecific levels.

Poly(ethylene glycol) monomethyl ether is a type of polyethylene glycol derivative.
The basic structure of Poly(ethylene glycol) monomethyl ether consists of repeating units of ethylene glycol.
In the case of Poly(ethylene glycol) monomethyl ether, a single methyl (CH3) group is attached to one end of the polyethylene glycol chain.

This modification gives PEG Monomethyl Ether its specific properties.
Poly(ethylene glycol) monomethyl ether possesses several important properties that make it useful in various applications.
Poly(ethylene glycol) monomethyl ether is highly water-soluble.

This property makes it useful for formulating aqueous solutions and products.
Poly(ethylene glycol) monomethyl ether is non-ionic, meaning it doesn't carry a net electrical charge.
This property contributes to its compatibility with a wide range of substances.

Poly(ethylene glycol) monomethyl ether has emollient properties, making it useful for softening and moisturizing the skin.
This characteristic is beneficial in cosmetic and personal care products.
Poly(ethylene glycol) monomethyl ether is chemically stable and does not readily undergo reactions with other substances.

Poly(ethylene glycol) monomethyl ether is available in different variants based on its molecular weight, which can range from low to high.
The choice of variant depends on the specific application and the desired properties, such as viscosity, solubility, and compatibility with other ingredients.
The presence of the polyethylene glycol chain in Poly(ethylene glycol) monomethyl ether imparts hydrophilic (water-attracting) properties to the compound.

This hydrophilic nature can influence its interactions with water, other molecules, and surfaces.
The addition of the methyl group at one end provides a degree of hydrophobic (water-repelling) character.
This balance between hydrophilicity and hydrophobicity allows Poly(ethylene glycol) monomethyl ether to play diverse roles in various formulations.

Poly(ethylene glycol) monomethyl ether is used in combination with other ingredients to achieve specific performance characteristics.
Blending it with other surfactants, emulsifiers, or polymers can help optimize the final product's stability, viscosity, texture, and other properties.
Poly(ethylene glycol) monomethyl ether, are used in drug formulation to overcome challenges such as poor solubility, instability, and rapid clearance from the body.

By modifying drug molecules with Poly(ethylene glycol) monomethyl ether, their therapeutic effects can be prolonged, reducing the frequency of administration and improving patient compliance.
Poly(ethylene glycol) monomethyl ether is a key strategy to enhance the properties of nanoparticles and improve their circulation time in the bloodstream.
Poly(ethylene glycol) monomethyl ether nanoparticles can improve drug delivery to target tissues and reduce non-specific interactions with blood components, thus enhancing their efficacy and safety.

One of the reasons PEG and its derivatives like Poly(ethylene glycol) monomethyl ether is widely used is their biocompatibility and inertness.
They generally do not provoke strong immune responses or induce toxicity.
This makes them suitable for various medical and pharmaceutical applications.

Poly(ethylene glycol) monomethyl ether itself is relatively stable and non-reactive, the environmental impact of PEG derivatives can vary.
Some Poly(ethylene glycol) monomethyl ether derivatives are considered biodegradable, while others may persist in the environment for longer periods.
Researchers and manufacturers are exploring eco-friendly alternatives and considering factors such as biodegradation and eventual breakdown into non-harmful components.

Research in the field of polymers and materials science, including Poly(ethylene glycol) monomethyl ether, is ongoing.
Scientists are continually exploring new ways to modify these compounds to suit specific applications, improve their biodegradability, and enhance their performance in various industries.

Uses
Poly(ethylene glycol) monomethyl ether has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) monomethyl ether has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) monomethyl ether of with an average molecular mass of 350.

Poly(ethylene glycol) monomethyl ether is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.
Poly(ethylene glycol) monomethyl ether's mild surfactant properties are employed in shampoos, body washes, and cleansing products.
Poly(ethylene glycol) monomethyl ether can be found in hair care products for its conditioning and anti-static effects.

Poly(ethylene glycol) monomethyl ether is used as a solvent or diluent in adhesive formulations.
Poly(ethylene glycol) monomethyl ether is added to coatings to improve flow, leveling, and texture.
Poly(ethylene glycol) monomethyl ether is used to stabilize solutions and dispersions in laboratory settings.

Poly(ethylene glycol) monomethyl ether applied in the functionalization and modification of nanoparticles, particularly in the medical and materials science fields.
Certain PEG derivatives, including Poly(ethylene glycol) monomethyl ether, are used as contrast agents in medical imaging techniques like MRI.
Poly(ethylene glycol) monomethyl ether is used in the development of biomaterials for tissue engineering and drug delivery.

Poly(ethylene glycol) monomethyl ether derivatives are approved as food additives, stabilizers, and texturizing agents in certain food and beverage products.
Poly(ethylene glycol) monomethyl ether derivatives are investigated for their potential use in wastewater treatment due to their ability to adsorb contaminants and improve Poly(ethylene glycol) monomethyl ether can enhance the solubility of poorly water-soluble drugs, making them easier to formulate into medications.

Poly(ethylene glycol) monomethyl ether derivatives are often used in drug delivery systems to improve the release profile of drugs and increase their bioavailability.
Poly(ethylene glycol) monomethyl ether can be found in ointments, creams, and lotions due to its ability to improve the texture and spreadability of these products.
In the cosmetics and personal care industry, Poly(ethylene glycol) monomethyl ether is used for its emollient and solubilizing properties.

Poly(ethylene glycol) monomethyl ether can help stabilize oil-in-water emulsions, which are common in creams, lotions, and other cosmetic products.
Poly(ethylene glycol) monomethyl ether can act as a mild surfactant in cleansing products like shampoos, body washes, and facial cleansers.
Poly(ethylene glycol) monomethyl ether can be used in skincare products to provide moisturization and improve the texture of the product.

Poly(ethylene glycol) monomethyl ether is used in various industrial applications due to its solubility and non-reactive nature.
Poly(ethylene glycol) monomethyl ether can be used as a solvent or diluent in adhesive formulations.
Poly(ethylene glycol) monomethyl ether can contribute to the properties of coatings, such as improved flow and leveling.

In laboratory settings, Poly(ethylene glycol) monomethyl ether might be used as a component in various solutions or as a stabilizing agent.
Poly(ethylene glycol) monomethyl ether nanoparticles are utilized for targeted drug delivery, enhancing drug accumulation in specific tissues while minimizing side effects.
Poly(ethylene glycol) monomethyl ether is used in textile dyeing and finishing processes to enhance dye penetration and improve fabric properties.

Poly(ethylene glycol) monomethyl ether and other PEG derivatives are used as stabilizers and excipients in a wide range of products.
Poly(ethylene glycol) monomethyl ether derivatives are approved for use as food additives and stabilizers in certain food and beverage products.
Poly(ethylene glycol) monomethyl ether derivatives can serve as emulsifiers, thickeners, and stabilizers in cosmetics, skincare products, and toiletries.

Poly(ethylene glycol) monomethyl ether can be used in pesticide formulations to improve the dispersion of active ingredients and enhance their effectiveness.
Poly(ethylene glycol) monomethyl ether can be added to paint formulations to improve the stability of pigments, enhance paint flow, and reduce defects.
Poly(ethylene glycol) monomethyl ether can be present in household cleaners and disinfectants, aiding in solubilizing active ingredients and improving cleaning performance.

Poly(ethylene glycol) monomethyl ether's used in some personal hygiene products like soaps and hand sanitizers for its emulsifying and cleansing properties.
Poly(ethylene glycol) monomethyl ether can be used in industrial degreasing formulations due to its ability to solubilize oils and greases.
Poly(ethylene glycol) monomethyl ether is used in textile dyeing and printing processes to improve dye dispersion and color uptake.

Poly(ethylene glycol) monomethyl ether can assist in leather processing by facilitating the absorption of dyes and finishing agents.
Poly(ethylene glycol) monomethyl ether can be employed in the production of food packaging materials, helping improve their properties such as flexibility and moisture resistance.
Poly(ethylene glycol) monomethyl ether, research laboratories, PEG Monomethyl Ether may be used as a component of reagents for various experiments and studies.

In vaccine development, PEG derivatives are used as adjuvants and formulation aids to enhance immune responses and improve vaccine stability.
Poly(ethylene glycol) monomethyl ether derivatives may be used in drilling fluids in the oil and gas industry to control rheological properties and improve fluid stability.
Poly(ethylene glycol) monomethyl ether can be used in paper coating formulations to improve printability, ink absorption, and surface smoothness.

Poly(ethylene glycol) monomethyl ether can be used as additives in cement and mortar formulations to improve workability and water retention.
Poly(ethylene glycol) monomethyl ether can be incorporated into metalworking fluids to enhance lubrication and cooling properties during machining processes.

Poly(ethylene glycol) monomethyl ether used as a solubilizer to enhance the solubility of poorly water-soluble drugs.
Poly(ethylene glycol) monomethyl ether incorporated into drug delivery systems to improve drug release profiles.
Poly(ethylene glycol) monomethyl ether found in skincare products like lotions and creams for its emollient properties.

Poly(ethylene glycol) monomethyl ether is used as an ingredient in shampoos, body washes, and other cleansing products due to its mild surfactant properties.
Poly(ethylene glycol) monomethyl ether is included in cosmetics to enhance product texture and stability.
Poly(ethylene glycol) monomethyl ether is used in adhesives as a solvent or diluent.

Poly(ethylene glycol) monomethyl ether added to coatings to improve flow and leveling properties.
Poly(ethylene glycol) monomethyl ether is used in various laboratory applications as a component of solutions or as a stabilizing agent.

Safety Considerations:
Poly(ethylene glycol) monomethyl ether is generally considered safe when used within recommended concentrations and guidelines.
However, as with any chemical substance, safety precautions should be taken.
Skin sensitization or irritation might occur in some individuals, so patch testing is advisable, especially in cosmetic and personal care applications.

Poly(ethylene glycol) monomethyl ether, especially in its concentrated form, can cause skin irritation in some individuals.
Sensitization reactions, where the skin becomes hypersensitive upon repeated exposure, can occur in susceptible individuals.
Poly(ethylene glycol) monomethyl ether can cause irritation to the eyes upon direct contact.

In case of eye contact, thorough rinsing with water is recommended.
Inhalation of vapor, mist, or aerosolized forms of Poly(ethylene glycol) monomethyl ether should be minimized, especially in confined spaces without proper ventilation
Some individuals may be allergic to Poly(ethylene glycol) monomethyl ether, which can lead to various adverse reactions upon exposure.

Poly(ethylene glycol) monomethyl ether is generally considered to have low toxicity, its presence in the environment could potentially contribute to pollution, especially if not properly managed.
Biodegradability varies among Poly(ethylene glycol) monomethyl ether derivatives, and those with higher molecular weights might be less biodegradable.

Synonyms
(C2-H4-O)mult-C-H4-O
9004-74-4
Carbowax Sentry Methoxypolyethylene Glycol
Ethylene oxide adduct of diethylene glycol monomethyl ether
Glycols, monomethyl ether
MPEG
Methoxy polyethylene glycol
Monomethoxypolyethylene glycol
PEG-6 METHYL ETHER
Poly(ethylene glycol methyl ether)
Poly(oxy- 1, 2- ethanediyl), a- methyl- ?- hydroxy-
Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-hydroxy-
Poly(oxy-1,2-ethanediyl), ?-methyl-?-hydroxy-
Poly(oxy-1,2-ethanediyl), alpha-methyl-omega-hydroxy
Polyethylene glycol methyl ether
Polyethylene glycol monomethyl ether
Polyethylene glycol monomethyl ether [NF]
Polyethylene glycol, monomethyl ether
UNII-6AXS45P1QU
UNII-89ES36762B
UNII-ENK4Y6S66X
UNII-H0S96329MO
UNII-P3R1BUP13I
UNII-UQE3488NAI
UNII-WXH089JZ5E