DESCRIPTION:
Vitamin B3 or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.
As a supplement, Nicotiamide (Vitamin B3) is used by mouth to prevent and treat pellagra (niacin deficiency)
While nicotinic acid (niacin) may be used for this purpose, Vitamin B3 has the benefit of not causing skin flushing.

CAS Number: 98-92-0
European Community (EC) Number: 202-713-4
IUPAC Name: pyridine-3-carboxamide
Molecular Formula: C6H6N2O



Nicotiamide (Vitamin B3) is a white powder.
Nicotiamide (Vitamin B3) is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a geroprotector.

Nicotiamide (Vitamin B3) is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.
An important compound functioning as a component of the coenzyme NAD.
Its primary significance is in the prevention and/or cure of blacktongue and pellagra.

Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.



As a cream, Nicotiamide (Vitamin B3) is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.
Nicotiamide (Vitamin B3) is a water-soluble vitamin.
Nicotiamide (Vitamin B3) is the supplement name, while nicotinamide is the scientific name.

Side effects of Nicotiamide (Vitamin B3) are minimal.
At high doses, liver problems may occur.
Normal amounts are safe for use during pregnancy.

Vitamin B3 is in the vitamin B family of medications, specifically the vitamin B3 complex.
Nicotiamide (Vitamin B3) is an amide of nicotinic acid.
Foods that contain Nicotiamide (Vitamin B3) include yeast, meat, milk, and green vegetables.

Nicotiamide (Vitamin B3) was discovered between 1935 and 1937.
Nicotiamide (Vitamin B3) is on the World Health Organization's List of Essential Medicines.
Nicotiamide (Vitamin B3) is available as a generic medication and over the counter.

Commercially, Nicotiamide (Vitamin B3) is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries, grains have Vitamin B3 added to them.


MEDICAL USES OF NICOTIAMIDE (VITAMIN B3):
Niacin deficiency:
Nicotiamide (Vitamin B3) is the preferred treatment for pellagra, caused by niacin deficiency.


Acne:
Nicotiamide (Vitamin B3) cream is used as a treatment for acne.
Nicotiamide (Vitamin B3) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Nicotiamide (Vitamin B3) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.


The application of 2% topical Nicotiamide (Vitamin B3) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Vitamin B3 has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.


Skin cancer:
Nicotiamide (Vitamin B3) at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.


CHEMISTRY OF NICOTIAMIDE (VITAMIN B3):
The structure of Nicotiamide (Vitamin B3) consists of a pyridine ring to which a primary amide group is attached in the meta position.
Nicotiamide (Vitamin B3) is an amide of nicotinic acid.
As an aromatic compound, it undergoes electrophilic substitution reactions and transformations of its two functional groups.


Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.
NAD+, the oxidized form of NADH, contains the nicotinamide moiety (highlighted in red)


INDUSTRIAL PRODUCTION OF NICOTIAMIDE (VITAMIN B3):
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of nicotinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Nicotinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014.


BIOCHEMISTRY OF NICOTIAMIDE (VITAMIN B3):
The active Nicotiamide (Vitamin B3) group on the molecule NAD+ undergoes oxidation in many metabolic pathways.
Nicotiamide (Vitamin B3), as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, nicotinamide is incorporated into NAD+ and nicotinamide adenine dinucleotide phosphate (NADP+).

NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.
If humans ingest nicotinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.

However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide.
NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the nicotinamide.


In NAD+, the nitrogen in the aromatic nicotinamide ring is covalently bonded to adenine dinucleotide.
The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.


BIOLOGICAL ROLE OF NICOTIAMIDE (VITAMIN B3):
Nicotiamide (Vitamin B3) occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Nicotiamide (Vitamin B3) is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Nicotiamide (Vitamin B3) can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.


FOOD SOURCES OF NICOTIAMIDE (VITAMIN B3):
Nicotiamide (Vitamin B3) occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Nicotiamide (Vitamin B3) is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Nicotiamide (Vitamin B3) is also available in higher doses

Vitamin B3, also called nicotinamide, is a form of vitamin B3.
Nicotiamide (Vitamin B3) is found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

Nicotiamide (Vitamin B3) is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to Vitamin B3 when it is taken in amounts greater than what is needed by the body.
Unlike niacin, Vitamin B3 doesn't help treat high cholesterol.


People use Vitamin B3 to prevent vitamin B3 deficiency and related conditions such as pellagra.
Nicotiamide (Vitamin B3) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

 




CHEMICAL AND PHYSICAL DATA OF NICOTIAMIDE (VITAMIN B3):
Formula, C6H6N2O
Molar mass, 122.127 g•mol−1
Density, 1.40 g/cm3 g/cm3
Melting point, 129.5 °C (265.1 °F)
Boiling point, 334 °C (633 °F)
Molecular Weight
122.12 g/mol
-0.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
122.048012819 g/mol
Monoisotopic Mass
122.048012819 g/mol
Topological Polar Surface Area
56Ų
Heavy Atom Count
9
Formal Charge
0
Complexity
114
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point, 150 - 160 °C (0.0007 hPa)
Density, 1.40 g/cm3 (20 °C)
Flash point, 182 °C
Ignition temperature, 480 °C
Melting Point, 128 - 131 °C (sublimed)
pH value, 6.0 - 7.5 (50 g/l, H₂O, 20 °C)
Bulk density, 360 kg/m3
Solubility, 691 g/l
Assay (perchloric acid titration, calculated on dried substance), 99.0 - 101.0 %
Assay (HPLC, calc. on dried substance), 98.5 - 101.0 %
Identity (IR-spectrum) (Ph Eur), passes test
Identity (IR-spectrum) (USP), passes test
Identity (coloring 1), passes test
Identity (coloring 2), passes test
Identity (UV/VIS-Spectrum), passes test
Appearance, White to almost white, crystalline powder
Appearance of solution (50 g/l; water), Clear, colourless, not more intense in color than reference solution BY₇
pH (50 g/l; water), 6.0 - 7.5
Melting range (lower value), ≥ 128 °C
Melting range (upper value), ≤ 131 °C
Absorption ratio (A 245 nm/A 262 nm), 0.63 - 0.67
Chloride (Cl), ≤ 210 ppm
Sulfate (SO₄), ≤ 190 ppm
Heavy metals (as Pb) (JP), ≤ 30 ppm
As (Arsenic), ≤ 3 ppm
Cu (Copper), ≤ 20 ppm
Pb (Lead), ≤ 2 ppm
Zn (Zinc), ≤ 25 ppm
Residual solvents (ICH Q3C), excluded by production process
Readily carbonisable substance, passes test
Related substances (HPLC) (Major unspecified impurity), ≤ 0.10 %
Related substances (HPLC) (Sum of all impurities), ≤ 0.2 %
Sulfated ash (600 °C), ≤ 0.1 %
Loss on drying (Vacuum; 18 h), ≤ 0.5 %




SAFETY INFORMATION ABOUT NICOTIAMIDE (VITAMIN B3):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






SYNONYMS OF NICOTIAMIDE (VITAMIN B3):
3 Pyridinecarboxamide
3-Pyridinecarboxamide
B 3, Vitamin
B3, Vitamin
Enduramide
Jenapharm, Nicotinsäureamid
Vitamin B3
Nicobion
Nicotinamide
Nicotinsäureamid Jenapharm
Papulex
Vitamin B 3
Vitamin B3
Vitamin PP
nicotinamide
Vitamin B3
98-92-0
3-Pyridinecarboxamide
Nicotinic acid amide
pyridine-3-carboxamide
vitamin PP
Aminicotin
Amixicotyn
Papulex
Nicotylamide
Endobion
Hansamid
Nicobion
Nikotinamid
Savacotyl
Benicot
Dipegyl
Pelmine
Nicotinic amide
Delonin amide
Pelonin amide
Austrovit PP
Vi-Nicotyl
Inovitan PP
Amnicotin
Nicamindon
Nicomidol
Nicosylamide
Nicotamide
Nicotilamide
Nicotililamido
Nicovitina
Nicovitol
Nicozymin
Niocinamide
Niacevit
Niamide
Nicamina
Nicasir
Nicofort
Nicogen
Nicotol
Nicovit
Niozymin
Nicota
Niko-tamin
3-Carbamoylpyridine
Nandervit-N
Nicotinamidum
Niavit PP
Nicosan 2
Nicotine amide
Nicotine acid amide
Nikotinsaeureamid
Pyridine-3-carboxylic acid amide
Vitamin B
Nicotylamidum
Nicotinsaureamid
beta-Pyridinecarboxamide
Pyridine, 3-carbamoyl-
Mediatric
Factor pp
m-(Aminocarbonyl)pyridine
3-Pyridinecarboxylic acid amide
Nicotinamida
Pelmin
Acid amide
Witamina PP
PP-Faktor
Amid kyseliny nikotinove
Amide PP
3-(aminocarbonyl)pyridine
Dipigyl
Niacinamid
Nicovel
Vitamin B (VAN)
CCRIS 1901
Nicotinsaureamid [German]
NAM
HSDB 1237
Nikotinsaeureamid [German]
Amid kyseliny nikotinove [Czech]
Nicotinamidum [INN-Latin]
Nicotinamida [INN-Spanish]
AI3-02906
NSC 13128
Nicotinamid
Nictoamide
Nicotinsaeureamid
3-Amidopyridine
Vi-noctyl
EINECS 202-713-4
NSC-13128
NSC-27452
b-Pyridinecarboxamide
Vitamin B3 (USP)
Vitamin B3 [USP]
UNII-25X51I8RD4
Nicotinamide [INN]
DTXSID2020929
CHEBI:17154
25X51I8RD4
Nicotinamide (Standard)
NSC13128
MFCD00006395
.beta.-Pyridinecarboxamide
Nicotinamide-(amide-15N)
Nicotinamide (Vitamin B3)
CHEMBL1140
DTXCID00929
MLS000069714
TPN COMPONENT VITAMIN B3
EC 202-713-4
VITAMIN B3 COMPONENT OF TPN
NSC27452
NCGC00093354-03
NCGC00093354-05
SMR000058212
Nicotinamide 10 microg/mL in Acetonitrile
VITAMIN B3 (II)
VITAMIN B3 [II]
Vitamin B3;Nicotinic acid amide;Vitamin B3
WLN: T6NJ CVZ
Nicotinamidum (INN-Latin)
Nicotinamida (INN-Spanish)
VITAMIN B3 (USP-RS)
VITAMIN B3 [USP-RS]
NICOTINAMIDE (MART.)
NICOTINAMIDE [MART.]
3 Pyridinecarboxamide
Vitamin B3 [USAN]
NICOTINAMIDE (EP IMPURITY)
NICOTINAMIDE [EP IMPURITY]
VITAMIN B3 (USP MONOGRAPH)
VITAMIN B3 [USP MONOGRAPH]
NICOTINAMIDE (EP MONOGRAPH)
NICOTINAMIDE [EP MONOGRAPH]
CAS-98-92-0
SR-01000721872
Niacotinamide
Nicosedine
Nicamid
nicotin-amide
Pahaba Control
Ultra Whitening
CellExosome HR
CellExosome SB
DEA No. 1405
Celonia CM
Ginseng Whitening
Dr. Cellmo
Royal GinsengCream
TOAS Rejuvenation
Nicotinamide,(S)
Vitamin B3 amide
Costem cell 5 N
Royal GinsengLotion
AAPE Skin Ampoule
CellExosome HE HR
Fantastic LightCream
Royal Ginseng Toner
Vita C Bright Serum
Vita C Bright Toner
Vitamin B3 Face Mask
Royal Ginseng Essence
Ultra Whitening Ample
TANIA PURECREAM
JUVEHEAL W Ampoule
Nicotinamidum (Latin)
BREXTEM S
NI-NICOTYL
Mediatric (Salt/Mix)
niacin - Vitamin B3
Dr. Color Effect Red
1yc5
DPC Aura Booster Mask
Dr Cellinme Mask Sheet
Opera_ID_775
Vita C Bright EyeCream
Miracle Laser Skin Mist
Niacin (as Vitamin B3)
Pyridine-3-carboxylamide
APLIN SPOT REMOVER
KARATICA I M CURE
VITAMIN B3 [FCC]
NICOTINAMIDE [MI]
TANIA PURE ESSENCE
VITA C BRIGHTCREAM
Pellagra-Preventing Factor
INTOMEDI HR PEPTIDE
VITAMIN B3 [HSDB]
VITAMIN B3 [INCI]
NICOTINAMIDE [JAN]
NYAAM NYAAM Vita Serum
RGO HYDRATION TONER
bmse000281
Miracle Moisturizer Essence
MolMap_000061
APLIN SPOT ALL KILL
MOISTIE PURE ESSENCE
VITAMIN B3 [VANDF]
DPC Whitening Booster Mask
SCHEMBL2926
AAPE Nutrient Facial Toner
Nicotinamide (JP17/INN)
NICOTINAMIDUM [HPUS]
NYAAM NYAAM Peptide Serum
Cellpium double essence toner
AAPE Continuous Renewal Mask
MLS001424246
Primerose Snail Hydro Essence
Shieldlife Whitening Ion Mask
Ultra V AQUA SHINE MASK
Ultra Whitening First Essence
NICOTINAMIDE [WHO-DD]
NICOTINAMIDE [WHO-IP]
by selected hyaluron day serum
Dr Cellinme Skin Care Ampoule
CELLPIUM REAL MASK PACK
Cellpium super richness ampoule
CAVIALL Wrinkle-Free PowerTox
Cellpium premiumEX hybrid toner
Revital Perfecting Dual Ampoule
SCHEMBL6278767
SGCUT00176
Daily Whitening Care Sheet Mask
Edge Cutimal Cat Whitening Mask
SCHEMBL19978192
BDBM27507
CELLBN MILKY TONE-UPCREAM
HY-B0150R
NYAAM NYAAM Skin Reborn Serum
A11HA01
Cellpium premiumEX hybrid essence
VITAMIN B3 [ORANGE BOOK]
BRIGHTUNING PEPTIDE AMPOULE
Nicotinamide, niacin, vitamin B3
HMS2052M21
HMS2090B05
HMS2093H03
HMS2236J03
HMS3370F21
HMS3394M21
HMS3655M20
HMS3713B22
HMS3884A16
Pharmakon1600-01505397
Ala-C Snail Cell Reparing Essence
AROCELL TIME REVERSE K I T
DR. GLODERM TABRX WHITENING
BCP07322
COSMEPURE BRIGHTENING CALMING
HY-B0150
THE SKIN HOUSE Vital BrightCream
THE SKIN HOUSE Vital BrightSerum
to_000073
ARILAC Brightening Mask Sheet Pack
Nicotinamide 1.0 mg/ml in Methanol
Nicotinamide, >=98.5% (HPLC)
Nicotinamide, >=99.5% (HPLC)
Tox21_111202
Tox21_201716
Tox21_302776
NICOTINAMIDUM [WHO-IP LATIN]
NSC759115
s1899
STL163867
THE SKIN HOUSE Vital Bright Toner
SFERANGS VITA C CAPSULEBOOSTER
AKOS005715850
Niveola P.H.c 3d Festival Mask Pack
Skin Project Ya Cooling Celluven Mask
THE SKIN HOUSE Vital BrightEmulsion
Tox21_111202_1
CCG-101149
CS-1968
DB02701
NC00399
NSC-759115
SB74497
Bk Cell 5days Of Secret Snow Whitening
EVECODE THREAD LIFTING MASK PACK
Nicotinamide 100 microg/mL in Methanol
Nicotinamide, >=98% (HPLC), powder
THE SKIN HOUSE Vital Bright Emulsion
THE SKIN HOUSE Vital Bright EyeCream
NCGC00093354-04
NCGC00093354-06
NCGC00093354-09
NCGC00256432-01
NCGC00259265-01
NIACIN (AS VITAMIN B3) [VANDF]
AS-13845
BN166252
COSMEPURE BRIGHTENING CALMING TONER
DERLADIE HerbalExtract BodySolution MIST
Nicotinamide, puriss., 99.0-101.0%
SY024804
DR. GLODERM TIME TO WHITENING MASK
FRESH MANDARIN AROMATHERAPY MASK27g
Nicotinamide, tested according to Ph.Eur.
SBI-0206826.P001
AN ADC SP INTENSIVE MOISTURE ESSENCE
CS-0694823
Derma Pella Facial Cleanser for Normal Skin
DR.ALTHEA POWER WHITENING GLUTATHIONE
FT-0631517
FT-0672696
FT-0773644
MIZON ENJOY VITAL UP TIME Whitening Mask
N0078
SW197779-3
The Hayan Cherry Blossom Brightening Essence
EN300-15612
Vitamin B3, meets USP testing specifications
C00153
D00036
DERMAHAN THE WHITENING MOISTURIZING MASK
Nicotinamide (Vitamin B3), analytical standard
AB00373895-13
AB00373895_15
AB00373895_16
Derma Pella Cleanser for Sensitive and Dry Skin
Nicotinamide, Vetec(TM) reagent grade, >=98%
A845925
AC-907/25014114
AROCELL X BELLE J SUPER POWER CELL AMPOULE
J9 ULTRA ADVANCED INTENSIVE SCALP SERUM V2
Q192423
LEBODY LAB RENEWAL DUAL EFFECT PEPTIDE SERUM
Q-201470
SR-01000721872-3
SR-01000721872-4
SR-01000721872-5
LEBODY LAB RENEWAL DUAL EFFECT IDEBENONE SERUM
MUSTUS DAILY HARVEST SQUEEZE TONE UP MASK PACK
PAPA RECIPE BOMBEE BRIGHTENING HONEY MASK PACK
SISEUNDEUSI LUMINANT MASK PACK STEP2(WHITENING)
Z33546463
F2173-0513
Vitamin B3;Nicotinic acid amide;Vitamin B3; Vitamin PP
Nicotinamide, British Pharmacopoeia (BP) Reference Standard
A186B02E-6C70-4E54-9739-79398D439AAA
Nicotinamide, European Pharmacopoeia (EP) Reference Standard
Vitamin B3, United States Pharmacopeia (USP) Reference Standard
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Vitamin B3, Pharmaceutical Secondary Standard; Certified Reference Material
Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture

Nicotinic acid, also known as niacin or vitamin B3, is a white crystal or crystalline powder, odorless or has a slight odor, slight sour taste.
Nicotinic acid is easily soluble in hot water, hot ethanol, alkaline water, propylene glycol, and chloroform.
Nicotinic acid is amphoteric and forms salts with acids as well as bases.

CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
EINECS Number: 200-441-0

Nicotinic acid can produce a variety of adverse effects, depending on the intake and health of the consumer.
The skin flushing reaction produced by nicotinic acid has been recognized for more than 70 years.
Nicotinic acid, melting point is 234-237℃.

Nicotinic acid is slightly soluble in water and ethanol; 100ml room temperature water can dissolve 1.6g.
When taken on an empty stomach, crystalline nicotinic acid in doses as small as 10 mg may produce a mild and transient, but noticeable, flushing reaction.

While not desirable, such reactions produce no known adverse consequences, and they are almost never perceptible when small amounts of nicotinic acid are taken in tablet or capsule form or consumed as part of food.
Nicotinic acid is sometimes referred to as nicotinic acid or nicotinamide and earlier called the P-P factor, antipellagra factor, antiblacktongue factor, and vitamin B4, niacin is available in several forms (niacin, niacinamide, niacinamide ascorbate, etc.) for use as a nutrient and dietary supplement.

Nicotinic acid is frequently identified with the B complex vitamin grouping.
Early in the research on niacin, a nutritional niacin deficiency was identified as the cause of pellagra in humans, blacktongue in dogs, and certain forms of dermatosis in humans.
Nicotinic acid deficiency is also associated with perosis in chickens as well as poor feathering of the birds.

Nicotinic acid and nicotinamide are colorless crystalline substances.
Nicotinic acid is slightly soluble in water and ethanol; nicotinamide is very soluble in water and moderately soluble in ethanol.

Nicotinic acids car boxyl group can form esters and anhydrides and can be reduced.
Both nicotinic acid and nicotinamide are very stable in dry form, but in solution nicotinamide is hydro lyzed by acids and bases to yield nicotinic.
The coenzyme forms of niacin are the pyridine nucleotides, NAD(H) and NADP(H).

In each of these compounds, the electron-withdrawing effect of the N-1 atom and the amide group of the oxidized pyridine nucleus enables the pyridine C-4 atom to react with many nucleophilic agents (e.g., sulfite, cyanide, and hydride ions).
It is the reaction with hydride ions (H?) that is the basis of the enzymatic hydrogen transfer by the pyridine nucleotides; the reaction involves the transfer of two electrons in a single step
Several substituted pyridines are antagonists of niacin in biological systems: pyridine-3-sulfonic acid, 3-acetylpyridine, isonicotinic acid hydrazine, 17 and 6-aminonicotinamide.

Nicotinic acid, Niacin or B3 is a water-soluble vitamin.
Derivatives of NADH, NADPH, NAD and NAD+ are a vitamin that has been affected in terms of energy, nuclear acids, protein fats and production.
Nicotinic acid cannot be included in the term vitamin B3.

Nicotinic acid was discovered by the oxidation of nicotine.
Nicotinic acid is derived from nicotinic acid + vitamin, as the name to be given to it is not intended to evoke nicotine.
Nicotinic acid can be seen in ancient texts that the name vitamin PP (short for the English term "pellegra prevention") was used for Nicotinic acid.

Nicotinic acid is a B vitamin that's made and used by your body to turn food into energy.
Nicotinic acid helps keep your nervous system, digestive system and skin healthy.
Nicotinic acid (vitamin B-3) is often part of a daily multivitamin, but most people get enough niacin from the food they eat.

Foods rich in Nicotinic acid include yeast, milk, meat, tortillas and cereal grains.
People use prescription Nicotinic acid (Niacor, Niaspan) to help control their cholesterol.
The recommended daily amount of Nicotinic acid for adult males is 16 milligrams (mg) a day and for adult women who aren't pregnant, 14 mg a day.

Nicotinic acid, or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.
The two most common forms of Nicotinic acid in food and supplements are nicotinic acid and nicotinamide.
The body can also convert tryptophan—an amino acid—to nicotinamide.

Nicotinic acid is water-soluble so that excess amounts the body does not need are excreted in the urine.
Nicotinic acid works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Nicotinic acid helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.

Niacin, also known as nicotinic acid, is an organic compound and a vitamer of vitamin B3, an essential human nutrient.
Nicotinic acid can be manufactured by plants and animals from the amino acid tryptophan.
Nicotinic acid is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.

Nicotinic acid as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness.
Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.

The amide derivative Nicotinic acid (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Although Nicotinic acid and nicotinamide are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, it does not reduce cholesterol nor cause flushing.

Nicotinic acid is recommended as a treatment for niacin deficiency because it can be administered in remedial amounts without causing the flushing, considered an adverse effect.
Nicotinic acid (also known as vitamin B3) is one of the water-soluble B vitamins.
Nicotinic acid is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside.

Nicotinic acid is naturally present in many foods, added to some food products, and available as a dietary supplement.
Nicotinic acid is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Nicotinic acid has a role as an antidote, an antilipemic drug, a vasodilator agent, a metabolite, an EC 3.5.1.19 (nicotinamidase) inhibitor, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a plant metabolite.

Nicotinic acid is a vitamin B3, a pyridinemonocarboxylic acid and a pyridine alkaloid.
Nicotinic acid is a conjugate acid of a nicotinate.
Nicotinic acid, or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.

The two most common forms of Nicotinic acid in food and supplements are nicotinic acid and nicotinamide.
The body can also convert tryptophan—an amino acid—to nicotinamide.
Nicotinic acid is water-soluble so that excess amounts the body does not need are excreted in the urine.

Nicotinic acid works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Nicotinic acid helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Nicotinic acid is also a prescription medication.

Amounts far in excess of the recommended dietary intake for vitamin functions will lower blood triglycerides and low density lipoprotein cholesterol (LDL-C), and raise blood high density lipoprotein cholesterol (HDL-C, often referred to as "good" cholesterol).
There are two forms: immediate-release and sustained-release Nicotinic acid.

Initial prescription amounts are 500 mg/day, increased over time until a therapeutic effect is achieved.
Immediate-release doses can be as high as 3,000 mg/day; sustained-release as high as 2,000 mg/day.
Despite the proven lipid changes, Nicotinic acid has not been found useful for decreasing the risk of cardiovascular disease in those already on a statin.

Nicotinic acid, on the other hand, is quite scarce in food and only recently started being sold as a supplement.
All three forms of vitamin B3 are converted to an important coenzyme called Nicotinic acid in the body.
Nicotinic acid is found in all living cells, and it plays a vital role in energy metabolism and maintaining proper cell functioning — particularly the functioning of our mitochondria, the power plants in our cells that turn food and oxygen into energy.

Nicotinic acid also plays an important role in protecting cells all over the body from age-related damage and decline in function.
While all three forms of vitamin B3 share common traits, each has a slightly different effect on the body and serves a different role when taken as a supplement.

Nicotinic acid (or nicotinic acid as it’s referred to in medical circles) was the third B vitamin to be discovered (hence the name B3).
Nicotinic acid wasn’t until about 1943, though, that a couple of doctors reported that niacin worked wonders in relieving the pain and stiffness associated with arthritis.
Nicotinic acid has a unique characteristic.

While not dangerous, Nicotinic acid can be uncomfortable, or even alarming, if you aren’t prepared for it.
Nicotinic acid, also known as vitamin B3, is a water-soluble vitamin.
Water-soluble vitamins are stored in the body in very limited amounts and are excreted through the urine.

Therefore, Nicotinic acid is a good idea to have them in your daily diet.
In addition to getting Nicotinic acid from dietary sources, the body can synthesize a form of niacin from the amino acid tryptophan.
Nicotinic acid causes the blood vessels to dilate or open up near the skin, which results in a hot, tingling sensation accompanied by a red flushing of the skin.

Generally, by starting with low amounts of Nicotinic acid (50 to 100 mg a day) and gradually increasing the dosage, a person can quickly build up a tolerance and avoid the flush.
Taking Nicotinic acid immediately following a meal will also lessen the flushing sensation.
Since Nicotinic acid isn’t something that drug companies can patent, it’s of little interest to them.

In fact, Nicotinic acid and niacinamide work on different circulatory systems and have their own unique benefits, making it important to take both.
Nicotinic acid in hydrochloric acid is highly suitable for checking the photometric accuracy of spectrometers in the UV range.
The Nicotinic acid spectrum shows a relatively broad maximum at the wavelengths 213 nm and 261 nm.

The Nicotinic acid filter solutions are filled and immediately fused under controlled conditions to become permanently airtight.
Nicotinic acid (NYE a sin) is used in combination with a healthy diet to lower bad cholesterol and increase good cholesterol.
Nicotinic acid is also used to decrease triglycerides.

Nicotinic acid can also be helpful in patients who have heart disease or who have had a heart attack.
Nicotinic acid may be used for other purposes; ask your health care provider or pharmacist if you have questions.
Nicotinic acid (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

The two coenzymes are required for oxidative reactions crucial for energy production, but they are also substrates for enzymes involved in non-redox signaling pathways, thus regulating biological functions, including gene expression, cell cycle progression, DNA repair and cell death.

Melting point: 236-239 °C(lit.)
Boiling point: 260C
Density: 1.473
refractive index: 1.5423 (estimate)
Flash point: 193°C
storage temp.: 2-8°C
solubility: 18g/l
pka: 4.85(at 25℃)
form: Powder
color: White to off-white
PH: 2.7 (18g/l, H2O, 20℃)
Odor: odorless to sl. odor, sour taste
Water Solubility: 1-5 g/100 mL at 17 ºC
Merck: 14,6525
BRN: 109591
BCS Class: 3
Stability: Stable. Incompatible with strong oxidizing agents. May be light sensitive.
InChIKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
LogP: 0.360

Nicotinic acid, 3-pyridinecarboxylicacid (Niacin), is effective in the treatment of all types ofhyperlipoproteinemia except type I, at doses above thosegiven as a vitamin supplement.
Nicotinic acid reduces VLDLsynthesis and, subsequently, its plasma products, IDL andLDL.
Plasma triglyceride levels are reduced because of thedecreased VLDL production.

Cholesterol levels are lowered,in turn, because of the decreased rate of LDL formationfrom VLDL.
Although niacin is the drug of choicefor type II hyperlipoproteinemias, Nicotinic acids use is limited becauseof the vasodilating side effects.
Flushing occurs inpractically all patients but generally subsides when thedrug is discontinued.

The hypolipidemic effects of Nicotinic acid may be caused byits ability to inhibit lipolysis (i.e., prevent the release ofFFAs and glycerol from fatty tissues).
Therefore, there is areduced reserve of FFA in the liver and diminution oflipoprotein biosynthesis, which reduces the production ofVLDL.
The decreased formation of lipoproteins leads to apool of unused cholesterol normally incorporated inVLDL.

Nicotinic acid excess cholesterol is then excreted throughthe biliary tract.
Nicotinic acid, also known as B3, nicotinic acid or nicotinamide, is an important enzymatic component required for the body to function normally.
This vitamin allows us to obtain energy from macronutrients (carbohydrates and fats).

Nicotinic acid, a very important micronutrient for energy synthesis, also contributes to the healthy functioning of the nervous and digestive systems.
In addition to these, Nicotinic acid is known that it is good for skin health and vitality, hair and eyes.
Nicotinic acid, an enzymatic component, has an important role in the metabolism of fats and sugars.

In this way, cells have the ability to provide the energy they need to continue their normal functions.
Nicotinic acid use of supplements containing niacin may be beneficial in terms of weight loss, as the substance will stimulate energy synthesis and help reduce the feeling of fatigue caused by weight loss.

Nicotinic acid also positively affects the vitality and health of the skin, eyes and hair and can be used for the treatment of skin conditions such as dermatitis, skin irritation and acne.
Adequate consumption of niacin contributes to the strengthening of the digestive and immune systems, while helping to fight oxidative stress.
Nicotinic acid also has positive effects on the health of the nervous system (it triggers units related to cognitive functions and memory).

Nicotinic acid deficiency can cause serious symptoms such as muscle weakness, digestive upsets (irritation of the mucus layer in the mouth, stomach, and intestines), loss of appetite, and skin rashes.
In more severe cases, Nicotinic acid can cause lesions in the central nervous system, leading to confusion and disorientation.
Studies have shown that Nicotinic acid can significantly lower cholesterol levels, but because the product is inexpensive, the pharmaceutical industry has not commercialized this supplement as a combined treatment for hypercholesteremia.

Since Nicotinic acid helps regulate fat and cholesterol levels, it can be used for the prevention or treatment of cardiovascular ailments.
Nicotinic acid, also called nicotinic acid and vitamin B3, water-soluble vitamin of the B complex.
Nicotinic acid is also called the pellagra-preventive vitamin because an adequate amount in the diet prevents pellagra, a chronic disease characterized by skin lesions, gastrointestinal disturbance, and nervous symptoms.

Nicotinic acid is interchangeable in metabolism with its amide, niacinamide (nicotinamide).
Like the vitamins thiamin (vitamin B1) and riboflavin (vitamin B2), niacin functions as part of a coenzyme involved in the metabolism of carbohydrates and acts to catalyze the oxidation of sugar derivatives and other substances.
Nicotinic acid, which was identified as a pellagra preventive in 1937, is widely distributed among plants and animals.

Nicotinic acid approximately 15 mg per day (1 mg = 0.001 gram) of nicotinic acid is required by humans.
In the intestinal tract, the Nicotinic acid tryptophan can be converted to niacin by bacterial action and thus can serve as a source for part of the required Nicotinic acid.
This explains scientists’ early observation that the protein in such foods as eggs and milk, both poor sources of niacin, can nevertheless prevent or cure pellagra.

Nicotinic acid is indicated to prevent vitamin deficiencies in pediatric and adult patients receiving parenteral nutrition as part of multivitamin intravenous injections.
Nicotinic acid oral tablets are indicated as a monotherapy or in combination with simvastatin or lovastatin to treat primary hyperlipidemia and mixed dyslipidemia
Nicotinic acid can also be used to reduce the risk of nonfatal myocardial infarctions in patients with a history of myocardial infarction and hyperlipidemia.

Nicotinic acid is also indicated with bile acid binding resins to treat atherosclerosis in patients with coronary artery disease and hyperlipidemia or to treat primary hyperlipidemia.
Finally Nicotinic acid is indicated to treat severe hypertriglyceridemia.
Nicotinic acid is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.

Nicotinic acid acts to decrease levels of very low density lipoproteins and low density lipoproteins, while increasing levels of high density lipoproteins.
Nicotinic acid can be converted to nicotinamide in the animal body and, in this form, is found as a component of two oxidation-reduction coenzymes, NAD and NADP.
The nicotinamide portion of the coenzyme transfers hydrogens by alternating between an oxidized quaternary nitrogen and a reduced tertiary nitrogen.

Enzymes that contain Nicotinic acid or NADP are usually called dehydrogenases.
They participate in many biochemical reactions of lipid, carbohydrate, and protein metabolism.
An example of an Nicotinic acid-requiring system is lactic dehydrogenase which catalyzes the conversion of lactic acid to pyruvic acid.

Nicotinic acid decreases formation and secretion of VLDL by the liver.
This action appears secondary to its ability to inhibit fatty acid mobilization from adipose tissue.
Circulating free fatty acids provide the main source of fatty acids for hepatic triglyceride synthesis, and lowering triglyceride synthesis lowers Nicotinic acid formation and secretion by the liver.

Since plasma VLDL is the source of Nicotinic acid, lowering VLDL can ultimately lower LDL.
In addition, nicotinic acid shifts LDL particles to larger (more buoyant) sizes.
The larger LDL particles are thought to be less atherogenic.

Nicotinic acid can also significantly increase plasma HDL levels; the mechanism is unknown.
Nicotinic acid is also known as vitamin B3, one of the B-complex vitamins.
Vitamins help to support the body's ability to make and break down natural compounds (metabolism) needed for good health.

Nicotinic acid (nicotinamide) is a different form of vitamin B3 and does not work the same as niacin.
Nicotinic acid is both a vitamin, i.e., an essential nutrient, marketed as a dietary supplement, and in the US, a prescription medicine.
As a Nicotinic acid, it is precursor of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

Severe deficiency of Nicotinic acid in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death.
Common psychiatric symptoms include irritability, poor concentration, anxiety, fatigue, loss of memory, restlessness, apathy, and depression.

Nicotinic acid is taken by mouth for high cholesterol and other fats.
Nicotinic acid is also used for low levels of a specific type of cholesterol, HDL.
Nicotinic acid is also used along with other treatments for circulation problems, migraine headache, Meniere's syndrome and other causes of dizziness, and to reduce the diarrhea associated with cholera.

Nicotinic acid is also taken by mouth to for preventing positive urine drug screens in people who take illegal drugs.
Nicotinic acid is taken by mouth for preventing vitamin B3 deficiency and related conditions such as pellagra.
Nicotinic acid is also taken by mouth for schizophrenia, hallucinations due to drugs, Alzheimer's disease and age-related loss of thinking skills, chronic brain syndrome, muscle spasms, depression, motion sickness, alcohol dependence, blood vessel swelling linked with skin lesions, and fluid collection (edema).

Some people take Nicotinic acid by mouth for acne, leprosy, attention deficit-hyperactivity disorder (ADHD), preventing premenstrual headache, improving digestion, protecting against toxins and pollutants, reducing the effects of aging, arthritis, lowering blood pressure, improving circulation, promoting relaxation, improving orgasms, and preventing cataracts.
Nicotinic acid is also used to improve exercise performance.

Nicotinic acid is a water-soluble vitamin that cannot be stored in body fat.
Nicotinic acid has two active components, nicotinic acid (niacin) and nicotinamide (niacinamide).
This vitamin plays a role in over 200 enzymatic reactions.

The body can synthesize Nicotinic acid in small amounts, provided it has sufficient stores of magnesium, vitamins B6 and B2, and tryptophan.
The latter is an essential amino acid (part of a protein)—that is, it is not produced by the body and must be obtained from food sources.
Nicotinic acid is a member of the B family of vitamins (B complex).

Nicotinic acida water-soluble vitamin.
Like the other B vitamins, Nicotinic acid helps make energy in your body.
Nicotinic acid helps your body use carbohydrates, fatty acids, and proteins.
Nicotinic acid is found in many plant and animal foods, such as yeast, meats (especially liver), grains, legumes, corn treated with alkali (such as corn used in tortillas), and seeds.

Nicotinic acid can be made by the liver from the amino acid tryptophan.
Nicotinic acid can be manufactured by plants and animals from the amino acid tryptophan.
Nicotinic acid is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.

Nicotinic acid as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide derivative Nicotinic acid (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).

Preparation
Nicotinic acid exists naturally in grain germs, meats and peanuts. It can also be synthesized artificially through the liquid phase method (potassium permanganate oxidation and nitric acid oxidation) and gas phase method (ozone oxidation, ammonia oxidation and air oxidation).
In the gas phase ammonia oxidation process, add 3-methyl pyridine, air and ammonia into the fluidized bed reactor and catalyze the reaction at 290～360℃,V2O5 to produce nicotinonitrile; then hydrolyze in sodium hydroxide aqueous solution at 160℃ to produce sodium nicotinate; finally, add hydrochloric acid to acidify, creating nicotinic acid.

In the potassium permanganate oxidation method, add potassium permanganate gradually at 80℃ to a mixture of 3-methyl pyridine and water, and then continue to mix for 30min at 85～90℃.
Distill to collect and reuse the unreacted 3-methyl pyridine and filter away the produced manganese dioxide.
Adjust the PH of the resulting nicotinic acid solution to 3.8～4.0 using hydrochloric acid, cool to 30℃ crystals, and filter to obtain crude nicotinic acid.

Dissolve the crude nicotinic acid in hot water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
6- hydroxyquinoline method Add sulfuric acid and quinoline into a reaction kettle and mix while maintaining heat at 150～160℃ for 5h.
Then with the temperature maintained at 180～220℃, slowly drop in nitric acid and the sulfuric acid mixture over the course of 36～40h.

While maintaining the temperature, mix for 2～3h to obtain a nicotinic acid solution and add water to dilute the solution.
Use 30％～33％ NaOH solution to neutralize the PH to 8～9. Cool and filter away the sodium sulfate and sodium nitrate crystals, add copper sulfate solution to the filtered liquid, and mix and heat to yield copper nicotinate precipitation.
Cool, filter and add the copper nicotinate to an adequate amount of water, drop in NaOH solution until PH>9 and the liquid is no longer blue, and filter away the produced cupric oxide.

Add a small amount of sodium sulfide solution to remove traces of copper and iron until the solution no longer produces black precipitate, and then filter.
Use hydrochloric acid to adjust the PH of the filtered liquid to 3.5～3.9, filter to yield crystals as crude nicotinic acid.

Dissolve the crude product in 12 times the amount of distilled water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
Yield is 35％～39％.
2-methyl-5-ethyl pyridine method With 2-methyl-5-ethyl pyridine as the raw ingredient, oxidize with nitic acid under high pressure and high temperatures, then decarboxylate to yield nicotinic acid.

Mechanisms:
Nicotinic acid reduces synthesis of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), lipoprotein(a) and triglycerides, and increases high-density lipoprotein cholesterol (HDL-C).[47] The lipid-therapeutic effects of niacin are partly mediated through the activation of G protein-coupled receptors, including hydroxycarboxylic acid receptor 2 (HCA2)and hydroxycarboxylic acid receptor 3 (HCA3), which are highly expressed in body fat.

HCA2 and HCA3 inhibit cyclic adenosine monophosphate (cAMP) production and thus suppress the release of free fatty acids (FFAs) from body fat, reducing their availability to the liver to synthesize the blood-circulating lipids in question.
A decrease in free fatty acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL-C turnover and reducing its production. Nicotinic acid also directly inhibits the action of diacylglycerol O-acyltransferase 2 (DGAT2) a key enzyme for triglyceride synthesis.

History
Huber first synthesized nicotinic acid in 1867. In 1914, Funk isolated nicotinic acid from rice polishings.
Goldberger, in 1915, demonstrated that pellagra is a nutritional deficiency.
In 1917, Chittenden and Underhill demonstrated that canine blacktongue is similar to pellagra.

In 1935, Warburg and Christian showed that niacinamide is essential in hydrogen transport as diphosphopyridine nucleotide (DPN).
In the following year, Euler et al. isolated DPN and determined its structure.
In 1937, Elvhehjem et al. cured blacktongue by administration of Nicotinic acid derived from liver.

In the same year, Fouts et al. cured pellagra with niacinamide.
In 1947, Handley and Bond established conversion of tryptophan to niacin by animal tissues
Carpenter found in 1951, that niacin in corn is biologically unavailable, and can be released only in very alkaline lime water of pH 11.

This explains why a Latin-American culture that used alkali-treated cornmeal to make tortilla was not at risk for niacin deficiency.
In 1955, Altschul and colleagues described large amounts of niacin as having a lipid-lowering property.
As such, Nicotinic acid is the oldest known lipid-lowering drug.[111] Lovastatin, the first 'statin' drug, was first marketed in 1987.

Uses
Nicotinic acid is an important factor in delivering hydrogen and fighting pellagra in organisms; it helps maintain skin and nerve health and stimulate digestion.
Nicotinic acid or niacinamide are used to treat and prevent pellagra.
This is a disease caused by niacin deficiency.

Nicotinic acid is also used to treat high cholesterol.
In some cases, niacin taken with colestipol can work as well as colestipol and a statin medicine.
Nicotinic acid USP granular is used for food fortification, as dietary supplement and as an intermediate of pharmaceuticals.

Nicotinic acid feed grade is used as vitamin for poultry, swines, ruminants, fish, dogs and cats, etc.
Nicotinic acid is also used as intermediate for nicotinic acid derivatives and technical applications.
Nicotinic acid is used to prevent and treat niacin deficiency (pellagra).

Nicotinic acid deficiency may result from certain medical conditions (such as alcohol abuse, malabsorption syndrome, Hartnup disease), poor diet, or long-term use of certain medications (such as isoniazid).
Nicotinic acid deficiency can cause diarrhea, confusion (dementia), tongue redness/swelling, and peeling red skin.

Nicotinic acid is also known as niacin and vitamin B3.
Nicotinic acid is a water-soluble conditioning agent that improves rough, dry, or flaky skin, helping smooth the skin and improve its suppleness.

Nicotinic acid enhances the appearance and feel of hair, by increasing body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
When used in the formulation of skin care products, niacinamide and niacin enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness.

Nicotinic acid is a precursor of the coenzymes NAD and NADP.
Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains.
Nicotinic acid is a water-soluble b-complex vitamin that is necessary for the growth and health of tissues.

Dietary deficiency is associated with pellagra.
Nicotinic acid was functions as a nutrient and dietary supplement that prevents pellagra.
The term "Nicotinic acid" has also been applied.

The term “Nicotinic acid” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid.
Nicotinic acid is essential for the proper functioning of the body, and a deficiency can lead to a condition called pellagra.
Supplementing with niacin can effectively treat and prevent pellagra.

Nicotinic acid is used as a medication to help lower elevated levels of LDL (low-density lipoprotein) cholesterol and triglycerides in the blood while increasing HDL (high-density lipoprotein) cholesterol.
Nicotinic acid is often prescribed for individuals with high cholesterol or those at risk of heart disease.

Due to its cholesterol-lowering properties, nicotinic acid can be prescribed to reduce the risk of heart attacks and strokes in certain patients with cardiovascular disease.
Nicotinic acid is sometimes used to treat hyperlipidemia, a condition characterized by high levels of lipids (fats) in the blood.
Nicotinic acid can also be used to manage dyslipidemia, a condition involving abnormal lipid levels in the blood, including high LDL cholesterol and triglycerides.

In some cases, nicotinic acid may be used to improve blood circulation in people with certain vascular conditions, like intermittent claudication, a symptom of peripheral arterial disease.
Nicotinic acid is sometimes used topically or in skincare products to improve the health and appearance of the skin.

Nicotinic acid can help address issues like acne, dry skin, and skin aging.
Nicotinic acid has been used in the prevention of migraines, although its effectiveness can vary from person to person.

Some studies have suggested that niacin supplementation may help improve certain symptoms of schizophrenia when used in combination with other medications.
Nicotinic acid is involved in various metabolic processes in the brain and may play a role in maintaining cognitive function.

Some research has explored its potential in Alzheimer's disease and age-related cognitive decline, though results are inconclusive.
High-dose Nicotinic acid has been used in certain detoxification programs for individuals trying to eliminate traces of illicit drugs, particularly marijuana, from their system.
This approach is controversial and should only be done under medical supervision.

Nicotinic acid is a crucial component in the production of energy within cells. It helps convert food into energy and is involved in various metabolic pathways.
Nicotinic acid has been shown to lower levels of Lp(a) cholesterol, which is associated with an increased risk of cardiovascular disease.
Nicotinic acid can be used in specific cases to target elevated Lp(a) levels.

Nicotinic acid, a form of niacin, is used in skincare products to address various skin conditions, such as acne, rosacea, and hyperpigmentation.
Nicotinic acid can help improve the appearance and texture of the skin.
Nicotinic acid has anti-inflammatory properties and is used in skincare products to soothe and calm irritated skin.

Nicotinic acid may also help reduce redness associated with certain skin conditions.
In addition to treating pellagra caused by niacin deficiency, nicotinic acid can sometimes be used to alleviate pellagra-like conditions that may result from other medical conditions or medications.

Safety Profile
Nicotinic acidv poison by intraperitoneal route.
Moderately toxic by ingestion, intravenous, and subcutaneous routes.
Human systemic effects: change in clotting factors, changes in platelet count.

Nicotinic acid, questionable carcinogen with experimental carcinogenic data.
When heated to decomposition it emits toxic fumes of NOx.

Synonyms
nicotinic acid
niacin
59-67-6
Pyridine-3-carboxylic acid
3-pyridinecarboxylic acid
3-Carboxypyridine
wampocap
vitamin B3
Niaspan
Acidum nicotinicum
nicolar
Apelagrin
Pellagrin
Akotin
Daskil
Efacin
Pelonin
Linic
nicamin
nicobid
nicocap
Enduracin
Nicodelmine
Niconacid
Nicotinipca
Pellagramin
Direktan
Nicacid
Nicangin
Peviton
Bionic
Diacin
Nicyl
Nyclin
Niac
Vitaplex N
Davitamon PP
Nico-Span
Tega-Span
Nicocidin
Nicocrisina
Niconazid
Nicotamin
Nicotene
Nicovasan
Nicovasen
Nipellen
SK-Niacin
Naotin
Niacor
Nicodon
Niconat
Nicosan 3
Nicosyl
Nicotil
Tinic
3-Carboxylpyridine
Nicotine acid
Nicodan
Nicoside
Slo-niacin
NICO
3-Picolinic acid
Nicotinsaure
Nico-400
Acide nicotinique
Pyridine-beta-carboxylic acid
Nicagin
anti-Pellagra vitamin
Caswell No. 598
PP Factor
Kyselina nikotinova
P.P. factor
Pellagra preventive factor
S115
Nicotinsaure [German]
Acido nicotinico
3-Pyridylcarboxylic acid
m-Pyridinecarboxylic acid
Niacin [USAN]
Kyselina nikotinova [Czech]
C6H5NO2
MFCD00006391
niacine
CCRIS 1902
Pyridine-carboxylique-3
EPA Pesticide Chemical Code 056701
Acide nicotinique [INN-French]
Acido nicotinico [INN-Spanish]
Acidum nicotinicum [INN-Latin]
HSDB 3134
Pyridine-carboxylique-3 [French]
AI3-18994
Pyridinecarboxylic acid, 3-
Niacin [USP]
SR 4390
BRN 0109591
Niacin extended release
Nicotinic acid [INN]
Vitamin B3 (Niacin)
Niacin (nicotinic acid)
EINECS 200-441-0
NIASPAN TITRATION STARTER PACK
NAH
CHEMBL573
beta-pyridinecarboxylic acid
NSC 169454
NSC-169454
niacin magnesium
niacin potassium
MLS000069603
Pyridine-.beta.-carboxylic acid
DTXSID1020932
UNII-2679MF687A
CHEBI:15940
Niacin (USP)
Niacinamide (TN)
2679MF687A
P.P. factor-pellagra preventive factor
Nicotinamide (TN)
CAS-59-67-6
NCGC00016268-02
Niacin (TN)
SMR000059024
[3H]nicotinic acid
[5, 6-3H]-niacin
EC 200-441-0
[3H]-Nicotinic acid
5-22-02-00057 (Beilstein Handbook Reference)
DTXCID10932
Nicotinicacid
Induracin
SR-01000722017
pellagra
Nikotinsaeure
Ncotnc acd
preventative factor
Niacin-Vitamin B3
Niaspan (TN)
3PyrCOOH
Niacor (TN)
Nicotinic Acid,(S)
Niacinamide Astra Brand
Niacinamide Merck Brand
Spectrum_001063
Nicotinic acid, Ph Eur
NIACIN [VANDF]
NIACIN [HSDB]
NIACIN [INCI]
5-pyridinecarboxylic acid
NIACIN [FCC]
NIACIN [USP-RS]
Opera_ID_1346
Prestwick0_000881
Prestwick1_000881
Prestwick2_000881
Prestwick3_000881
Pyridine-3-carbonic acid
Spectrum2_000006
Spectrum3_000515
Spectrum4_000965
Spectrum5_001287
VITAMIN B-3
3-Pyridyl carboxylic acid
Nicotinic acid-d3(major)
Nicotinamide-carbonyl-14C
Nicotinic acid; (Niacin)
WLN: T6NJ CVQ
3-pyridine carboxylic acid
Astra Brand of Niacinamide
bmse000104
D06NVJ
Merck Brand of Niacinamide
Niacinamide Jenapharm Brand
Nicotinic acid, >=98%
Nicotinic acid, USP grade
SCHEMBL1433
Nicotinamide (JP15/INN)
Nicotinic acid [INN:BAN]
Nicotinic acid; (Niacin)
NICOTINIC ACID [MI]
Niacinamide Pharmagenix Brand
Oprea1_514398
VITAMIN B3 [VANDF]
BSPBio_000662
BSPBio_002069
KBioGR_001309
KBioSS_001543
NIACIN [ORANGE BOOK]
NICOTINIC ACID [JAN]
Nicotinic acid (Vitamin B3)
BIDD:GT0644
DivK1c_000695
Nicotinic acid (JP17/INN)
SIMCOR COMPONENT NIACIN
SPECTRUM1500430
.beta.-Pyridinecarboxylic acid
Jenapharm Brand of Niacinamide
SPBio_000011
SPBio_002881
ADVICOR COMPONENT NIACIN
NIACIN [USP MONOGRAPH]
NICOTINIC ACID [VANDF]
BPBio1_000730
GTPL1588
GTPL1594
NICOTINIC ACID [MART.]
NICOTINIC ACID [WHO-DD]
NICOTINIC ACID [WHO-IP]
Pharmagenix Brand of Niacinamide
BDBM23515
HMS502C17
KBio1_000695
KBio2_001543
KBio2_004111
KBio2_006679
KBio3_001569
ABT-919
NIACIN COMPONENT OF SIMCOR
NICOTINIC ACID [EMA EPAR]
NINDS_000695
HMS1570B04
HMS1920P17
HMS2091H22
HMS2097B04
HMS2236A05
HMS3259K21
HMS3371E07
HMS3655K08
HMS3714B04
NIACIN COMPONENT OF ADVICOR
Pharmakon1600-01500430
Nicotinic acid, analytical standard
BCP16301
HY-B0143
STR00112
Tox21_110337
Tox21_201420
Tox21_302904
AC8691
BBL037343
CCG-38340
NICOTINIC ACID [EP IMPURITY]
Nicotinic acid, for synthesis, 99%
NSC169454
NSC757241
s1744
STK301803
NICOTINIC ACID [EP MONOGRAPH]
AKOS000118980
Nicotinic acid, >=99.5% (HPLC)
Tox21_110337_1
AM81316
CS-1946
DB00627
LS-2334
NC00524
Nicotinic Acid 1.0 mg/ml in Methanol
NSC-757241
PS-4255
SDCCGMLS-0066610.P001
IDI1_000695
NCGC00016268-01
NCGC00016268-03
NCGC00016268-04
NCGC00016268-05
NCGC00016268-08
NCGC00016268-09
NCGC00094734-01
NCGC00094734-02
NCGC00256537-01
NCGC00258971-01
AC-22484
ACIDUM NICOTINICUM [WHO-IP LATIN]
BP-21419
NCI60_001041
Nicotinic acid, NIST(R) SRM(R) 148
Nicotinic acid, plant cell culture tested
SY011111
SBI-0051456.P003
Nicotinic Acid [Matrix for MALDI-TOF/MS]
AB00052050
FT-0600004
FT-0672715
FT-0672716
FT-0672717
FT-0672718
FT-0773496
N0082
N1103
Nicotinic acid 10 microg/mL in Acetonitrile
Nicotinic acid, purum, >=99.0% (HPLC)
SW197229-3
EN300-16693
C00253
D00049
Niacinamide, Nicotinic acid amide, Nicotinamide
Nicotinic acid, SAJ special grade, >=99.5%
AB00052050-13
AB00052050_14
AB00052050_15
Nicotinic acid, meets USP testing specifications
AC-907/25014105
L001199
METHYL NICOTINATE IMPURITY A [EP IMPURITY]
Nicotinic acid, Vetec(TM) reagent grade, >=98%
Q134658
J-523605
SR-01000722017-2
SR-01000722017-3
SR-01000722017-4
Z56755709
3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E
F2191-0082
Niacin, United States Pharmacopeia (USP) Reference Standard
Nicotinic acid, certified reference material, TraceCERT(R)
Nicotinic acid, European Pharmacopoeia (EP) Reference Standard
Nicotinic acid, matrix substance for MALDI-MS, >=99.5% (HPLC)
InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9
Nicotinic acid, for inorganic trace analysis, >=99.999% (metals basis)
Niacin (Nicotinic Acid), Pharmaceutical Secondary Standard; Certified Reference Material
101113-41-1
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98%

NICOTINYL ALCOHOL HF N° CAS : 62756-44-9 Nom INCI : NICOTINYL ALCOHOL HF Nom chimique : 3-Pyridinemethanol, hydrofluoride (1:1) N° EINECS/ELINCS : 700-352-1 (L) Antiplaque : Aide à protéger contre la formation de plaque dentaire

NIPACIDE BIT 20; Exocide 20, 1,2-benzisothiazol-3(2H)-one, Benzisothiazolinone, Benzisothiazolin-3-one, Cas No: 2634-33-5

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a polyethylene glycol derivative of hydrogenated castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is produced by the ethoxylation of hydrogenated castor oil, which involves treating the oil with ethylene oxide.

CAS Number: 61788-85-0
Molecular Formula: C57H110O9 (C2H4O)n
EINECS number: 500-147-5

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can be used to emulsify and solubilize oil-in-water (o/w) emulsions.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)0 is a commercial product name for PEG-40 Hydrogenated Castor Oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a specific formulation or brand of PEG-40 Hydrogenated Castor Oil that is manufactured by NIKKOL Group, a company specializing in the production of cosmetic and personal care ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is commonly used in the cosmetic and personal care industry as an emulsifier, surfactant, solubilizer, and fragrance ingredient.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) has surfactant properties, allowing it to help stabilize and emulsify oil and water-based formulations.
It can enhance the texture and spreadability of cosmetic products and improve the solubility of certain ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can act as a fragrance carrier, aiding in the dispersion of fragrances throughout formulations.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is primarily used as an emulsifier, surfactant, and solubilizer in cosmetic and personal care formulations.
It helps to stabilize emulsions, allowing the blending of oil and water-based ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) also aids in the dispersion of insoluble substances in water-based products and improves the solubility of certain ingredients.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can contribute to the texture and sensory attributes of cosmetic products.
It can enhance the spreadability, smoothness, and overall feel of formulations, making them easier to apply and providing a pleasant sensory experience to the user.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is compatible with a wide range of ingredients commonly used in cosmetic and personal care products.
It can be used in various formulations, including creams, lotions, serums, shampoos, conditioners, and bath products.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)n is a process that involves adding hydrogen to castor oil, resulting in a more stable and solid form.

This process alters the properties of castor oil, making it more suitable for certain applications.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a company specializing in the development, production, and distribution of cosmetic and personal care ingredients.
They offer a wide range of ingredients, including emulsifiers, surfactants, moisturizers, and active ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is typically an amber-colored liquid with a slightly thick consistency.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) may have a mild fatty or waxy odor.
The product is generally miscible in both water and oil, which allows it to be easily incorporated into various cosmetic formulations.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) acts as an effective emulsifier, helping to create stable emulsions by reducing the surface tension between oil and water phases. It assists in the formation and stabilization of oil-in-water (o/w) emulsions, where oil droplets are dispersed in a continuous water phase.
As a surfactant, NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) reduces the interfacial tension between two immiscible substances, such as oil and water.

This property enables it to enhance the wetting, dispersing, and foaming capabilities of cosmetic products.
NIKKOL HCO-40 can act as a solubilizer, aiding in the dispersion and solubilization of lipophilic (oil-soluble) ingredients in water-based formulations.
It helps to improve the transparency and stability of solutions containing oil-soluble substances.

When stored under proper conditions, NIKKOL HCO-40 has good stability and a reasonably long shelf life.
However, it is recommended to follow the manufacturer's guidelines for storage temperature and conditions to ensure product quality and efficacy over time.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil), including NIKKOL HCO-40, is typically considered safe for use in cosmetics and personal care products.
It is approved by regulatory authorities such as the U.S. Food and Drug Administration (FDA) and is widely used in the industry.
However, it is important to comply with relevant regulations and guidelines specific to the intended market and ensure that the product meets all necessary safety standards.

As with any cosmetic ingredient, it is important to ensure the quality and safety of NIKKOL HCO-40.
The manufacturer should provide information on the specifications, handling guidelines, recommended usage levels, and potential safety considerations associated with their product.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is advisable to consult the manufacturer's documentation or contact them directly for specific technical details and safety information.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) in the name refers to the polyethylene glycol chain length, indicating the number of ethylene oxide units that are attached to the hydrogenated castor oil molecule.
Different chain lengths can result in variations in the properties and performance of the ingredient.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is utilized in various cosmetic and personal care products, including creams, lotions, serums, shampoos, conditioners, and bath products.
It provides formulation stability, emulsification, and enhances product sensory attributes.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) acts as a solubilizer for systems with much alcohol.
It is a white to pale yellow liquid, petrolatum-like or waxy substance. NIKKOL HCO-40 is used in cosmetics.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is used in cosmetics as a solubiliser, emulsifier, surfactant and emollient.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is derived from Castor oil and is useful in producing products that disperse in water whilst offering good moisturising properties.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is an emollient and emulsifying agent created from a mixture of synthetic polyethylene glycol (PEG) + natural castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) also helps other ingredients solubilize in a formula which improves both aesthetics and performance.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) or liquid raw material, this vegetable-based solubiliser is also used as a surfactant and cleanser in cosmetic preparations, and was designed for use as an emulsifier in aqueous formulations containing a large water phase.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) has a yellow colour with a mild odour.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a combination of polyethylene glycol and hydrogenated castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is naturally occurring oil extracted from castor beans from plant Ricinus communis.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a colorless to pale yellow liquid with a distinct taste and odor.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is rich in triglycerides and fatty acids like oleic acid, ricinoleic acid, and linoleic acid.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is used in many cosmetic products.
A combination of both PEG-40 and castor oil makes it contain the benefits of both the molecules in a single molecule.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)’s mostly used as an emulsifier and surfactant but most often it is used to solubilize fragrances into water-based formulas.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)l is a synthetic ingredient used in a variety of cosmetics and skincare products to help improve the texture and effectiveness of the formulation.
The main functions of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) are as a surfactant, emulsifier, and emollient.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil), Crouret 40 is a vegetable-derived nonionic surfactant which finds widespread use as an emollient, oil-in water emulsifier, lubricant and effective solubiliser.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can act as a wetting agent in styling waxes and imparts superfatting benefits in detergent systems.

Boiling point: 348℃[at 101 325 Pa]
Density: 0.983[at 20℃]
vapor pressure: 0Pa at 25℃
Flash point: 242℃
storage temp.: 4°C, protect from light
Odor: at 100.00?%. bland
Water Solubility: 500μg/L at 20℃
LogP: 8 at 25℃

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a derivative of hydrogenated castor oil that is commonly used in cosmetics as an emulsifying agent and fragrance ingredient. It has been approved by the FDA for external use and is generally considered safe in concentrations up to 100%.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) and other similar compounds are typically not known to cause skin irritation.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a softening and emulsifying agent created from a mixture of synthetic polyethylene glycol (PEG) + natural castor oil.
It also helps dissolve other ingredients into a formula that improves both aesthetics and performance.
Basically, it combines water and oil substances and allows the other ingredients to dissolve in a sticky way for a pleasant result.

The weight and size of this ingredient is too large to penetrate beyond the skin surface, but that's okay - this type of emollient is required on the surface to minimize moisture loss and give it a soft feel.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is considered non-sensitizing and safe for use in cosmetics, with defined concentrations ranging from 0.00007% to 22% (based on a 2015 report).

However, there is some debate regarding the safety of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil).
While it has received FDA approval for external use, the Cosmetics Database has classified it as potentially hazardous.
According to the database, there is a chance of contamination with potentially harmful impurities.

The potential toxicity of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is related to the manufacturing process known as ethoxylation.
During this process, NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is treated with ethylene oxide, which is derived from petroleum.
This process may introduce a contaminant called 1,4-dioxane, which is known to be a carcinogen.

However, the presence of 1,4-dioxane is not guaranteed in every batch.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is an amber-colored liquid with a slightly thick consistency and a mild natural fatty scent.
It is commonly used as an emulsifier, surfactant, and fragrance ingredient in various cosmetic products.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) and PEG Hydrogenated Castor Oils, including PEG 40, belong to a group of polyethylene glycol derivatives derived from castor oil.
They are widely used in the cosmetic industry, serving as skin conditioning agents and surfactants in over 500 formulations.
The length of the polymer chain varies depending on the amount of ethylene oxide used during synthesis.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is important to note that the maximum concentration used in animal sensitization studies was 50% for PEG Castor Oils and 100% for PEG Hydrogenated Castor Oils.
Therefore, it is generally considered safe to use PEG Castor Oils in cosmetic formulations at concentrations up to 50%, and PEG Hydrogenated Castor Oils as intended for cosmetic use.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil), which include PEG Castor Oils, are nonionic surfactants with a wide range of applications in industrial and household formulations.
They are used as cleaning agents, antistatic agents, dispersants, emulsifiers, defoamers, and softeners in textile, home care, personal care, and agricultural products.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) are derived from castor oil and contain traditional fatty acids along with the unique ricinoleic acid.

Uses
NIKKOL HCO-40 is widely used as an emulsifier in cosmetic formulations.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to create stable emulsions by allowing the blending of oil and water-based ingredients.
This is particularly useful in the production of creams, lotions, and other emulsion-based products.

As a surfactant, NIKKOL HCO-40 reduces the surface tension between different substances, such as oil and water.
It helps to improve the wetting, dispersing, and foaming properties of cosmetic products.
This makes it suitable for use in shampoos, body washes, and other cleansing formulations.

NIKKOL HCO-40 acts as a solubilizer, aiding in the dispersion and solubilization of lipophilic (oil-soluble) ingredients in water-based formulations.
It helps to improve the transparency and stability of solutions containing oil-soluble substances.
This is beneficial in products such as serums, toners, and sprays.

NIKKOL HCO-40 can also be used as a fragrance ingredient.
It helps to disperse and carry fragrances throughout cosmetic formulations, ensuring their even distribution and enhancing the scent of the final product.
Due to its emulsifying properties, NIKKOL HCO-40 can contribute to the texture and sensory attributes of cosmetic products.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can improve the spreadability, smoothness, and overall feel of formulations, making them easier to apply and providing a pleasant user experience.
NIKKOL HCO-40 finds application in a wide range of cosmetic and personal care products, including creams, lotions, serums, moisturizers, cleansers, shampoos, conditioners, body washes, and various other skincare and haircare formulations.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is used to solubilize vitamins, water insoluble active substances and essential oils in water or mixtures of water and alcohol.
NIKKOL HCO-40 is often used in moisturizing creams and lotions.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to emulsify water and oil-based ingredients, allowing for a smooth and creamy texture.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) also contributes to the spreadability and absorption of the product, leaving the skin feeling moisturized and hydrated.
NIKKOL HCO-40 is utilized in various haircare formulations, such as shampoos, conditioners, and hair styling products.
It helps to create a stable emulsion, ensuring the even distribution of ingredients and enhancing the efficacy of the product.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can also improve the texture of haircare products, making them easier to apply and rinse off.
Due to its surfactant properties, NIKKOL HCO-40 is commonly used in body washes, shower gels, and bath products.
It helps to create a luxurious lather, improving the cleansing and foaming properties of the formulation.

NIKKOL HCO-40 is commonly used as a key ingredient in cleansing oils.
It helps to emulsify and lift away dirt, impurities, and makeup from the skin.
It provides a gentle and effective cleansing experience, leaving the skin clean and refreshed.

Due to its emulsifying properties, NIKKOL HCO-40 is utilized in makeup removers.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) assists in breaking down and removing makeup, including waterproof formulations.
It helps to dissolve and lift away makeup without excessive rubbing or irritation.

NIKKOL HCO-40 is incorporated into body lotions and body butters to enhance their emollient and moisturizing properties.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to create a smooth and creamy texture that spreads easily on the skin.
It contributes to the long-lasting hydration and nourishment of the skin.

NIKKOL HCO-40 finds application in lip balms and lipsticks. It helps to create a soft and smooth texture, ensuring easy application on the lips.
It contributes to the moisturizing and conditioning properties of lip products, keeping the lips hydrated and protected.
NIKKOL HCO-40 is sometimes incorporated into anti-aging formulations, such as serums and creams.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to deliver active ingredients, such as antioxidants and peptides, to the skin effectively.
It enhances the absorption and penetration of these ingredients, promoting their efficacy in reducing the signs of aging.
NIKKOL HCO-40 is used in the formulation of personal care wipes, including makeup wipes and baby wipes.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) aids in the dispersion of cleansing agents and moisturizing ingredients on the wipe, ensuring their efficient release when in contact with the skin.
NIKKOL HCO-40 is sometimes included in sunscreen formulations.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) assists in the even distribution of sun-protective ingredients, such as UV filters, ensuring their effective coverage on the skin.

NIKKOL HCO-40 is used in various decorative cosmetics, including foundations, BB creams, and liquid lipsticks.
It helps to create smooth and lightweight formulations, improving the blendability and application of the product.
It can also enhance the dispersibility of pigments, ensuring even color distribution.

NIKKOL HCO-40 is utilized as a fragrance ingredient in perfumes, colognes, and body sprays.
It helps to solubilize and disperse the fragrance oils, allowing for a well-rounded and long-lasting scent experience.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) may cause skin irritation, especially in individuals with sensitive or compromised skin.

Safety
Prolonged or repeated contact with concentrated forms of the ingredient may increase the risk of irritation.
Contact with the eyes can lead to irritation, redness, and discomfort.
Avoid direct contact with the eyes and flush with water if it occurs.

Some individuals may develop an allergic or sensitization reaction to NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil).
If you experience any signs of allergic reaction, such as itching, redness, rash, or swelling, discontinue use and consult a healthcare professional.

Inhalation
Inhalation of aerosolized forms or fine particles of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) may irritate the respiratory system.
Adequate ventilation should be maintained when working with powdered or aerosol forms of the ingredient.

Environmental Impact
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is considered to have low environmental toxicity.
However, it is important to handle and dispose of the ingredient in accordance with local regulations to prevent any potential harm to aquatic life or the environment.

Synonyms
NIKKOL HCO 60
HYDROGENATED CASTOR OIL
ETHOXYLATED
POLYETHYLENE GLYCOL 2000 HYDROGENATED CASTOR OIL
POLYOXYETHYLENE (40) HYDROGENATED CASTOR OIL
CREMOPHOR RH 40
CREMOPHOR RH 40/6
HCO 40 HCO 50 HCO 60
akypo rox CO400
alkamuls CRH/40-C;castor oil (ricinus communis)
hydrogenated, ethoxylated (40 mol
EO average molar ratio)
cremophor RH 40;croduret 40
emanon CH-40
findet ARH-52; lipocol HCO-40;nikkol HCO-40
nikkol HCO-40 pharm;polyethylene glycol40 hydrogenated castor oil
polyoxyethylene (40) hydrogenated castor oil
Polyoxyl 40 hydrogenated castor oil [NF]
7YC686GQ8F
02NG325BQG
0ZNO9PJJ9J
R07D3A9614
0WZF1506N9
MH590ECD4O
WE09129TH5
43SW2U113W
61788-85-0
Ethoxylated hydrogenated castor oil
UNII-02NG325BQG
UNII-7YC686GQ8F
Polyethylene glycol (25) hydrogenated castor oil
Polyethylene glycol (30) hydrogenated castor oil
Polyethylene glycol (35) hydrogenated castor oil
Polyethylene glycol (45) hydrogenated castor oil
Polyethylene glycol (5) hydrogenated castor oil
Polyethylene glycol (50) hydrogenated castor oil
Polyethylene glycol (54) hydrogenated castor oil
PEG-100 Hydrogenated castor oil
PEG-16 Hydrogenated castor oil
PEG-20 Hydrogenated castor oil
PEG-200 Hydrogenated castor oil
PEG-25 Hydrogenated castor oil
PEG-30 Hydrogenated castor oil
PEG-35 Hydrogenated castor oil
Polyethylene glycol (55) hydrogenated castor oil
Polyethylene glycol (60) hydrogenated castor oil
Polyethylene glycol (7) hydrogenated castor oil
Polyethylene glycol (80) hydrogenated castor oil
PEG-40 Hydrogenated castor oil
PEG-45 Hydrogenated castor oil
PEG-5 Hydrogenated castor oil
Polyethylene glycol 2000 hydrogenated castor oil
PEG-50 Hydrogenated castor oil
PEG-54 Hydrogenated castor oil
PEG-55 Hydrogenated castor oil
PEG-60 Hydrogenated castor oil
PEG-7 Hydrogenated castor oil
PEG-80 Hydrogenated castor oil
Polyethylene glycol (100) hydrogenated castor oil
Polyethylene glycol (16) hydrogenated castor oil
Polyethylene glycol (200) hydrogenated castor oil
Castor oil, hydrogenated, ethoxylated, HCO 50
Polyoxyethylene (5) hydrogenated castor oil
Polyoxyethylene (50) hydrogenated castor oil
Polyoxyethylene (54) hydrogenated castor oil
Polyoxyethylene (55) hydrogenated castor oil
Polyoxyethylene (100) hydrogenated castor oil
Polyoxyethylene (16) hydrogenated castor oil
Polyoxyethylene (200) hydrogenated castor oil
Polyoxyethylene (25) hydrogenated castor oil
Polyoxyethylene (30) hydrogenated castor oil
Polyoxyethylene (35) hydrogenated castor oil
Polyoxyethylene (40) hydrogenated castor oil
Polyoxyethylene (45) hydrogenated castor oil
Castor oil, hydrogenated, ethoxylated, HCO 60
Polyoxyethylene hydrogenated castor oil 60
CCRIS 6926
Cremophor RH 40
Cremophor RH 40/60
HCO 40
HCO 50
HCO 60
Hydrogenated castor oil, ethoxylated
Nikkol HCO 60
Polyoxyethylene (80) hydrogenated castor oil
Castor oil, hydrogenated, ethoxylated
Castor oil, hydrogenated, ethoxylated, HCO 40
Polyoxyethylene (60) hydrogenated castor oil
Polyoxyethylene (7) hydrogenated castor oil
Cremophor RH40
UNII-0ZNO9PJJ9J
UNII-MH590ECD4O
UNII-R07D3A9614
UNII-WE09129TH5
UNII-43SW2U113W
UNII-0WZF1506N9
Polyoxyl 40 hydrogenated castor oil

N-isopropylhydroxylamine; 5080-22-8; 2-Propanamine, N-hydroxy-; N-(propan-2-yl)hydroxylamine; N-hydroxypropan-2-amine; N-Isopropylhydroxylamine oxalate salt; N-hydroxypropan-2-amine; N-hydroxypropan-2-amine sulfate (2:1) CAS NO.: 5080-22-8

N-Isopropyl Hydroxylamine is a colorless to light yellow liquid with a characteristic odor.
N-Isopropyl Hydroxylamine is soluble in water, alcohol, and ether.
N-Isopropyl Hydroxylamine is a weak base and reacts with acids to form salts.

CAS Number: 7681-93-8



APPLICATIONS


N-Isopropyl Hydroxylamine is used as an intermediate in the production of pharmaceuticals and agrochemicals.
N-Isopropyl Hydroxylamine is used as a reducing agent in organic synthesis.
N-Isopropyl Hydroxylamine is used as a stabilizer for rubber and polymers.

N-Isopropyl Hydroxylamine is used in the synthesis of nitroso compounds.
N-Isopropyl Hydroxylamine is used in the production of antioxidants and corrosion inhibitors.

N-Isopropyl Hydroxylamine is used as an inhibitor in the polymerization of vinyl monomers.
N-Isopropyl Hydroxylamine is used in the synthesis of oximes.

N-Isopropyl Hydroxylamine is used in the purification of aldehydes and ketones.
N-Isopropyl Hydroxylamine is used as an intermediate in the production of dyestuffs.

N-Isopropyl Hydroxylamine is used as an antioxidant in fuels and lubricants.
N-Isopropyl Hydroxylamine is used as a polymerization inhibitor in the production of acrylics and methacrylics.
N-Isopropyl Hydroxylamine is used as a corrosion inhibitor in cooling water systems.

N-Isopropyl Hydroxylamine is used as a reducing agent in the synthesis of hydrazones.
N-Isopropyl Hydroxylamine is used in the production of biocides and fungicides.

N-Isopropyl Hydroxylamine is used as a reagent in the determination of aldehydes and ketones.
N-Isopropyl Hydroxylamine is used in the synthesis of heterocyclic compounds.

N-Isopropyl Hydroxylamine is used as an antioxidant in food packaging materials.
N-Isopropyl Hydroxylamine is used as a chelating agent in the production of metal ions.
N-Isopropyl Hydroxylamine is used as an inhibitor in the synthesis of ethylene oxide.

N-Isopropyl Hydroxylamine is used as an intermediate in the production of perfume ingredients.
N-Isopropyl Hydroxylamine can be used as an antioxidant in the polymerization of styrene.

N-Isopropyl Hydroxylamine is used as a reducing agent in organic synthesis reactions.
N-Isopropyl Hydroxylamine is used in the synthesis of pharmaceutical compounds.

N-Isopropyl Hydroxylamine can be used as an oxygen scavenger in the corrosion protection of metals.
N-Isopropyl Hydroxylamine can be used to remove iron oxide deposits in industrial equipment.
N-Isopropyl Hydroxylamine is used in the manufacture of rubber accelerators.

N-Isopropyl Hydroxylamine can be used to reduce nitro compounds to amines.
N-Isopropyl Hydroxylamine is used as a blocking agent for the protection of carbonyl groups in organic synthesis.

N-Isopropyl Hydroxylamine is used as an intermediate in the production of agrochemicals.
N-Isopropyl Hydroxylamine can be used as an initiator in the polymerization of vinyl monomers.

N-Isopropyl Hydroxylamine is used in the synthesis of N-hydroxylamines.
N-Isopropyl Hydroxylamine can be used as a stabilizer for nitroxyl radicals in the formation of free radicals.

N-Isopropyl Hydroxylamine is used in the production of antioxidants for the prevention of degradation of polymers.
N-Isopropyl Hydroxylamine can be used in the synthesis of anti-inflammatory drugs.
N-Isopropyl Hydroxylamine is used in the preparation of benzyl oxime derivatives.

N-Isopropyl Hydroxylamine can be used in the preparation of 1,2,3,4-tetrahydroquinolines.
N-Isopropyl Hydroxylamine is used in the synthesis of isoxazole derivatives.

N-Isopropyl Hydroxylamine can be used in the preparation of imidazole derivatives.
N-Isopropyl Hydroxylamine is used in the synthesis of heterocyclic compounds.

N-Isopropyl Hydroxylamine can be used as a reducing agent for the synthesis of organophosphorus compounds.
N-Isopropyl Hydroxylamine is used in the production of corrosion inhibitors for the protection of metals.

N-Isopropyl Hydroxylamine can be used as an intermediate in the synthesis of pesticides.
N-Isopropyl Hydroxylamine is used in the synthesis of biologically active molecules.

N-Isopropyl Hydroxylamine can be used in the production of antioxidants for food preservation.
N-Isopropyl Hydroxylamine is used in the synthesis of inhibitors for the treatment of Alzheimer's disease.

N-Isopropyl Hydroxylamine is used as a reagent in organic synthesis.
N-Isopropyl Hydroxylamine is an important intermediate in the production of pharmaceuticals and agrochemicals.

N-Isopropyl Hydroxylamine is used in the preparation of anti-tumor agents.
N-Isopropyl Hydroxylamine is used as a reducing agent in the synthesis of various compounds.
N-Isopropyl Hydroxylamine is used in the manufacture of rubber antioxidants.

N-Isopropyl Hydroxylamine is used as a stabilizer for emulsion polymerization.
N-Isopropyl Hydroxylamine is used as an antioxidant in the production of synthetic rubber.

N-Isopropyl Hydroxylamine is used as a corrosion inhibitor in cooling water systems.
N-Isopropyl Hydroxylamine is used in the manufacture of electronic chemicals.

N-Isopropyl Hydroxylamine is used in the production of photographic chemicals.
N-Isopropyl Hydroxylamine is used in the synthesis of dyes and pigments.

N-Isopropyl Hydroxylamine is used in the production of high-performance coatings.
N-Isopropyl Hydroxylamine is used as a polymerization inhibitor.
N-Isopropyl Hydroxylamine is used as a stabilizer for polyurethane foams.

N-Isopropyl Hydroxylamine is used as a flame retardant in plastics.
N-Isopropyl Hydroxylamine is used in the production of epoxy resins.

N-Isopropyl Hydroxylamine is used in the synthesis of specialty chemicals.
N-Isopropyl Hydroxylamine is used as an intermediate in the manufacture of surfactants.

N-Isopropyl Hydroxylamine is used in the production of adhesives and sealants.
N-Isopropyl Hydroxylamine is used as a curing agent in the production of composites.

N-Isopropyl Hydroxylamine is used in the manufacture of flavor and fragrance compounds.
N-Isopropyl Hydroxylamine is used as a chelating agent in the production of detergents.
N-Isopropyl Hydroxylamine is used in the synthesis of biologically active compounds.

N-Isopropyl Hydroxylamine is used in the production of ion exchange resins.
N-Isopropyl Hydroxylamine is used in the manufacture of lubricants and fuels.

N-Isopropyl Hydroxylamine is commonly used as a reducing agent in organic chemistry reactions.
N-Isopropyl Hydroxylamine is used as an oxygen scavenger in boiler water treatment.
N-Isopropyl Hydroxylamine is used as an intermediate in the production of pharmaceuticals.

N-Isopropyl Hydroxylamine can be used to reduce nitro compounds to amines.
N-Isopropyl Hydroxylamine is used as a polymerization inhibitor in the production of monomers.
N-Isopropyl Hydroxylamine is used in the synthesis of hydroxylamine derivatives.

N-Isopropyl Hydroxylamine is used as an antioxidant in the production of plastics and rubber.
N-Isopropyl Hydroxylamine is used as an intermediate in the production of agrochemicals.

N-Isopropyl Hydroxylamine can be used to synthesize oximes from carbonyl compounds.
N-Isopropyl Hydroxylamine is used in the synthesis of organosilicon compounds.

N-Isopropyl Hydroxylamine is used as a reducing agent in the preparation of metal nanoparticles.
N-Isopropyl Hydroxylamine is used as a stabilizer in the production of emulsion polymers.

N-Isopropyl Hydroxylamine is used in the manufacture of paper and pulp products.
N-Isopropyl Hydroxylamine can be used as a precursor to synthesize amides from carboxylic acids.

N-Isopropyl Hydroxylamine is used in the production of detergents and surfactants.
N-Isopropyl Hydroxylamine is used as a stabilizer in the production of polyurethane foams.
N-Isopropyl Hydroxylamine can be used to reduce aromatic nitro compounds to amino compounds.

N-Isopropyl Hydroxylamine is used as a reducing agent in the synthesis of heterocyclic compounds.
N-Isopropyl Hydroxylamine is used in the manufacture of coatings and paints.

N-Isopropyl Hydroxylamine is used as a stabilizer in the production of vinyl acetate polymers.
N-Isopropyl Hydroxylamine can be used to reduce aldehydes and ketones to alcohols.

N-Isopropyl Hydroxylamine is used in the synthesis of chiral compounds.
N-Isopropyl Hydroxylamine is used as a reducing agent in the preparation of carboxylic acids.

N-Isopropyl Hydroxylamine is used in the production of synthetic fibers.
N-Isopropyl Hydroxylamine is used as a stabilizer in the production of synthetic resins.



DESCRIPTION


N-Isopropyl Hydroxylamine is a chemical compound with the molecular formula C3H9NO, and its IUPAC name is N-(propan-2-yl)oxime.
N-Isopropyl Hydroxylamine is an organic compound with the chemical formula (CH3)2CHNH(OH).

N-Isopropyl Hydroxylamine is a colorless to light yellow liquid with a characteristic odor.
N-Isopropyl Hydroxylamine is soluble in water, alcohol, and ether.
N-Isopropyl Hydroxylamine is a weak base and reacts with acids to form salts.

N-Isopropyl Hydroxylamine is used as a reducing agent in various chemical reactions.
N-Isopropyl Hydroxylamine is commonly used in the synthesis of pharmaceuticals and agrochemicals.

N-Isopropyl Hydroxylamine can also be used as a polymerization inhibitor.
N-Isopropyl Hydroxylamine is often used in the preparation of nitrones, which are important intermediates in organic synthesis.

N-Isopropyl Hydroxylamine is a useful reagent for the preparation of oximes from carbonyl compounds.
N-Isopropyl Hydroxylamine can also be used to prepare hydroxamic acids from esters and amides.

N-Isopropyl Hydroxylamine has been shown to be an effective corrosion inhibitor in acidic media.
N-Isopropyl Hydroxylamine can be used to prevent corrosion of steel and other metals.
N-Isopropyl Hydroxylamine has been investigated as a potential antitumor agent.

N-Isopropyl Hydroxylamine has been found to be effective against certain types of cancer cells.
N-Isopropyl Hydroxylamine has also been investigated as a potential treatment for Alzheimer's disease.

N-Isopropyl Hydroxylamine has been shown to inhibit the formation of beta-amyloid fibrils, which are a hallmark of Alzheimer's disease.
N-Isopropyl Hydroxylamine has also been investigated as a potential treatment for Parkinson's disease.

N-Isopropyl Hydroxylamine has been found to protect dopaminergic neurons from oxidative stress.
N-Isopropyl Hydroxylamine has been used in the production of surfactants and other specialty chemicals.
N-Isopropyl Hydroxylamine is a versatile compound with a wide range of applications in various fields of chemistry.



PROPERTIES


Chemical formula: C3H9NO
Molecular weight: 75.11 g/mol
Appearance: Colorless to light yellow liquid
Odor: Ammonia-like odor
Melting point: -30 °C (-22 °F; 243 K)
Boiling point: 82-83 °C (180-181 °F; 355-356 K)
Density: 0.90 g/cm3
Solubility: Soluble in water, ethanol, and diethyl ether
Flash point: 16 °C (61 °F; 289 K)
Autoignition temperature: 400 °C (752 °F; 673 K)
Vapor pressure: 78.4 hPa (20 °C)
Refractive index: 1.4175 (20 °C)
Viscosity: 0.5 mPa·s (20 °C)
pH: 6-8 (10% aqueous solution)
Explosive limits: 1.3%-9.5% (in air)
Stability: Stable under normal conditions
Hazard identification: Flammable liquid and vapor, may be harmful if inhaled, swallowed, or absorbed through the skin
Molecular structure: Consists of an isopropyl group (-CH(CH3)2) attached to a hydroxylamine group (-NH2OH) via an N atom
Reactivity: Reacts with strong oxidizing agents, strong acids, and metals
Storage: Store in a cool, dry, well-ventilated area, away from heat, sparks, flames, and incompatible materials
Handling: Use personal protective equipment, such as gloves and goggles, when handling N-Isopropyl Hydroxylamine, and avoid skin contact and inhalation of vapors
Incompatibility: Incompatible with strong oxidizing agents, strong acids, and metals
Corrosivity: Non-corrosive to metals and tissues
Biodegradability: Readily biodegradable under aerobic conditions
Ecotoxicity: Low toxicity to aquatic organisms
Waste disposal: Dispose of N-Isopropyl Hydroxylamine and its solutions in accordance with local regulations and approved procedures.



FIRST AID


If N-Isopropyl Hydroxylamine comes into contact with the eyes, skin, or is inhaled or ingested, immediate first aid measures should be taken.
Here are some general guidelines:

Eye contact:

Rinse the eyes thoroughly with water for at least 15 minutes, lifting the upper and lower lids occasionally.
Seek medical attention if irritation persists.


Skin contact:

Remove any contaminated clothing and wash the affected skin with soap and water.
Seek medical attention if irritation or rash develops.


Inhalation:

Move the affected person to fresh air immediately.
If the person is having difficulty breathing, seek medical attention immediately.


Ingestion:

If ingested, do not induce vomiting.
Rinse the mouth with water and seek medical attention immediately.


If N-Isopropyl Hydroxylamine is spilled, contain the spill and prevent it from spreading.
Clean up the spill with absorbent materials and dispose of them properly.
Wear protective clothing and gloves when handling N-Isopropyl Hydroxylamine.

Store N-Isopropyl Hydroxylamine in a cool, dry, well-ventilated area away from incompatible materials.
Always follow proper safety procedures when handling N-Isopropyl Hydroxylamine.



HANDLING AND STORAGE


N-Isopropyl Hydroxylamine should be stored in a cool, dry, and well-ventilated area.
Keep the container tightly closed when not in use.
N-Isopropyl Hydroxylamine should be stored away from sources of heat, ignition, and strong oxidizing agents.

The storage area should be free from incompatible materials and substances.
Store N-Isopropyl Hydroxylamine in a fire-resistant storage area.

Keep away from children and pets.
Avoid skin contact, inhalation, or ingestion of N-Isopropyl Hydroxylamine.
Wear appropriate personal protective equipment when handling N-Isopropyl Hydroxylamine, including gloves, safety glasses, and a lab coat.

Do not eat, drink, or smoke when working with N-Isopropyl Hydroxylamine.
Do not allow N-Isopropyl Hydroxylamine to come into contact with water.

Store N-Isopropyl Hydroxylamine in a container made of a compatible material, such as glass or stainless steel.
Label all containers of N-Isopropyl Hydroxylamine with the appropriate hazard warning and safety information.

Avoid storing N-Isopropyl Hydroxylamine near food, feed, or pharmaceuticals.
Do not reuse containers that previously held N-Isopropyl Hydroxylamine without proper cleaning and decontamination.

Ensure that the storage area for N-Isopropyl Hydroxylamine is equipped with appropriate fire suppression and emergency response equipment.
Store N-Isopropyl Hydroxylamine away from direct sunlight and other sources of ultraviolet radiation.
Store N-Isopropyl Hydroxylamine away from acids, bases, and other incompatible materials.

Do not store N-Isopropyl Hydroxylamine in poorly ventilated areas.
Ensure that the storage area for N-Isopropyl Hydroxylamine is well-marked and clearly labeled.
Store N-Isopropyl Hydroxylamine in a way that prevents accidental spills or leaks.



SYNONYMS


N-Isoxylhydroxylamine
N-Isopropylhydroxylamine
NIPH
IPHA
Isopropylhydroxylamine
2-Hydroxy-2-methylpropylamine
Isopropyl 2-hydroxy-2-methylpropylamine
2-Hydroxy-2-methylpropyl-N-hydroxylamine
2-(Hydroxy)-2-methyl-1-propanamine-N-oxide
N-Isopropyl-2-hydroxy-2-methylpropylamine
N-(1-Methylethyl)-2-(hydroxy)-2-methylpropylamine
2-Methyl-2-(hydroxy)-1-propylamine
NSC 5352
BRN 1745973
AC1L1TE2
AI3-52221
18924-01-1
IPA-HA
N-isopropylhydroxylamine
N-Isopropylhydroxylamin
Isopropylhydroxylamine
N-Isopropylhydroxylamine
2-Hydroxy-2-methylpropan-N-amine
Isonitroso-2-propanol
N-Isopropoxyamine
2-Amino-2-methylpropanol oxime
Hydroxyamine, N-isopropyl-
Isopropyl-N-hydroxyamine
N-hydroxyisopropylamine
N-Isopropylhydroxyammonium
N-(1-Methylethyl)hydroxylamine
2-Hydroxy-2-methylpropylamine N-oxide
N-Isopropylhydroxylammonium
2-Amino-2-methyl-1-propanol N-oxide
N-Isopropylhydroxyaminium
N-Isopropyl-2-hydroxy-2-methylpropanamine
Hydroxylamine, N-(1-methylethyl)-
2-Hydroxy-2-methylpropan-1-aminium
N-Isopropylhydroxyamine hydrochloride
N-isopropyl-N-hydroxy-amine
Hydroxyamine, isopropyl-
2-Amino-2-methyl-1-propanol N,N-dimethyl-N-oxide.

N-isopropylhydroxylamine; 5080-22-8; 2-Propanamine, N-hydroxy-; N-(propan-2-yl)hydroxylamine; N-hydroxypropan-2-amine; N-Isopropylhydroxylamine oxalate salt; N-hydroxypropan-2-amine; N-hydroxypropan-2-amine sulfate (2:1) CAS NO.: 5080-22-8

NIACIN, N° CAS : 59-67-6 - Niacine (Vitamine B3).acide nicotinique; CAS : 59-67-6; Synonymes : nicotinic acid;3-Pyridinecarboxylic acid;3-Carboxypyridine;Pyridine-beta-carboxylic;Niacin;3-CARBOXYLPYRIDINE;Acide nicotinique;ACIDUM NICOTINICUM;AKOTIN;Anti-pellagra vitamin;ANTIPELLAGRA VITAMIN;APELAGRIN;BIONIC;DASKIL;DAVITAMON PP;DIREKTAN;EFACIN;Kyselina nikotinova;LINIC;NAH, NAOTIN; Niacin; Niacinamide;Niaspan;NICACID;NICAGIN;NICAMIN;NICANGIN;Nico-400;NICO-SPAN;Nicobid;Nicocap;NICOCIDIN NICOCRISINA;NICODAN;NICODELMINE;NICODON;NICOLAR;NICONACID;NICONAT;NICONAZID;NICOROL;NICOSAN 3;NICOSIDE;NICOSYL;NICOTAMIN;NICOTENE;Nicotil;NICOTINE ACID;nicotinic acid;NICOTINIPCA;Nicotinoylhydrazine; Nicotinsaure; Nicovasan;Nicovasen;NICYL;Nipellen;NYCLIN;P.P. factor-pellagra preventive; factor; Pellagramin; PELLAGRIN; PELONIN; Peviton; PP FACTOR; Pyridine-3-carbonic acid; Pyridine-3-carboxylic acid; Pyridine-beta-carboxylic; PYRIDINE-BETA-CARBOXYLIC ACID;Pyridine-carboxylique-3; S115; SK-Niacin; SR 4390; VITAPLEX N; WAMPOCAP Nom INCI : NIACIN, Nom chimique : 3-Pyridinecarboxylic acid. N° EINECS/ELINCS : 200-441-0. Additif alimentaire : E375. Ses fonctions (INCI); Antistatique : Réduit l'électricité statique en neutralisant la charge électrique sur une surface. Agent lissant : Diminue la rugosité ou les irrégularités pour rendre la peau uniforme. Noms français : 3-CARBOXYLPYRIDINE; 3-CARBOXYPYRIDINE; 3-PYRIDINECARBOXYLIC ACID; ACIDE NICOTINIQUE; ACIDE PYRIDINECARBOXYLIQUE-3; NICOTINE ACID; NICOTINIC ACID; PYRIDINE-3-CARBONIC ACID; PYRIDINE-3-CARBOXYLIC ACID; PYRIDINE-BETA-CARBOXYLIC ACID. Utilisation et sources d'émission: Médicament

Nickel Carbonate; Nickel(II) carbonate (1:1); Nickel monocarbonate; nickelous carbonate; carbonic acid nickel salt; C.I. 77779; cas no: 3333-67-3

SYNONYMS Nickel(II) carbonate (1:1); Nickel monocarbonate; nickelous carbonate; carbonic acid nickel salt; C.I. 77779; AS CO. 3333-67-3

Nickel Sulfate; Nickel(II)Sulfate Hexahydrate; Nickelous sulfate, 6-hydrate; Sulfuric Acid, Nickel (2+) Salt, Hexahydrate; Nickel Monosulfate Hexahydrate; Blue Salt; Single Nickel Salt; Nickelsulfat (German); Sulfato de níquel (Spanish); Sulfate de nickel cas no: 7786-81-4

Synonyms: L-Isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L-methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto-D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl-L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl-L-lysine cyclic (3->7),(8->11),(13->19),(23->26),(25->28)-pentakis(sulfide);NISIN;nsc-112903;Nisin Ready Made Solution;Streptococcus element (element);Nisin from Lactococcus lactis Vetec(TM) reagent grade, 2.5% (balance sodium chloride and denatured milk solids);Nisin from Lactococcus lactis;NISINSTREPTOCOCCUS LACTIS CAS: 1414-45-5

Ethylparaben. Nipagin® A is a water-soluble preservative. It offers broad spectrum of activity against bacteria and fungi. It is a short-chain paraben for higher water solubility. It exhibits low order of toxicity and effectiveness at low concentrations. It has stability over a broad pH-range and global acceptance in personal care applications. Nipagin® A shows good biodegradability at environmental concentrations. It is used in syndets & bar soaps, shampoos & showers products, liquid soaps, wet wipes, hair conditioners, antiperspirants & deodorants, hair styling products, creams, lotions and decorative cosmetics.Nipagin™ A is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals. it is suitable for both rinse-off and leave-on formulations. This product is supplied as a white, or almost white crystalline powder.Almost odourless, small, colourless crystals or a white, crystalline powder.Small, colorless crystals or powder at room temperature.Crystals from dilute alcohol.Nipagin A is a broad spectrum antimicrobial agent de signed for preservation of a wide range of cosmetics,toiletries and topical pharmaceuticals. Nipagin A is suitable to preserve both rinse- off and leave- on formu lations.Typical use concentrations of Nipagin A is 0.1 – 0.3 %. Combinations of p- Hydroxybenzoic acid esters, e.g. with Nipasol M, Nipagin M or Nipabutyl exhibit in creased activity compared with individual esters.Nipagin A is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in water. The low aqueous solubility does not affect the microbi ological efficacy of the esters. Most formulations requiring preservation contain a significant amount of water. This may mean that Nipagin A cannot readily be added directly to the formulation. Other methods of incorporation are quite straightfor ward however, and are listed below.The solubility of Nipagin A increases greatly as the temperature of the water rises. Therefore a concentrate may be made up by heating an appropriate quantity of water to 60- 100 °C prior to addition of Nipagin A. This concentrate may then be added to the formulation, pro vided that the ester concentration does not exceed its solubility in the formulation at normal ambient tem peratures. Nipagin A is readily soluble in polar organic solvents. Where such a solvent is already part of a formulation an Nipagin A concentrate may be made up prior to addi tion. If a suitable solvent is not already part of thefor mulation, a highly concentrated solution may be made up e.g. 32 % in Ethanol, which would give insignificant residual levels of ethanol in the end product. Nipagin A is readily soluble in lipophilic ingredients and may be introduced to a formulation by adding to the oil phase with some warming before any emulsifica tion stage. In multiphase systems, such as emulsions, it is often advisable to use a combination of aqueous dis solution with either of the other methods to ensure ade quate preservation. The ester may be incorporated in the water to its maximum solubility and any further quanti ties may be dissolved in the oil phase, or solvent, as appropriate. Nipagin A remains fully stable over a wide pH range from 4- 8. In general the lower the pH of the formula tion, the more active is Nipagin A. That can result in a lower use concentration when the pH of the formulation is more acidic. Nipagin A is a short-chain paraben for higher water solubility. Benefits Broad spectrum of activity against bacteria and fungi Low order of toxicity Effectiveness at low concentrations Stability over a broad pH-range Water-soluble Biodegradability at environmental concentrations Global acceptance in personal care applications Chemical name Ethyl 4-Hydroxybenzoate INCI designation Ethylparaben Product properties *) Appearance (20°C): White, or almost white crystalline powder. Chemical and physical data Melting point: 115 - 118 oC Assayacc. BP/PH.Eur: 98.0 - 102.0 % IUPAC name Ethyl 4-hydroxybenzoate Other names Ethyl paraben; Ethyl parahydroxybenzoate; Ethyl para-hydroxybenzoate; Ethyl p-hydroxybenzoate; 4-Hydroxybenzoic acid ethyl ester Identifiers CAS Number: 120-47-8 Ethylparaben is an ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol, It has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen. It is a paraben and an ethyl ester. Antimicrobial Preservative Used in Cosmetics and Personal Care. Uses Nipagin A is a broad spectrum antimicrobial agent designedfor preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals.Nipagin A is suitable to preserve both rinse- off and leave- on formulations. Applications Typical use concentrations of Nipagin A is 0.1 – 0.3 %.Combinations of p- Hydroxybenzoic acid esters, e.g. with Nipasol M, Nipagin M or Nipabutyl exhibit increased activity compared with individual esters. Incorporation Nipagin A is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in water.The low aqueous solubility does not affect the microbiological efficacy of the esters.Most formulations requiring preservation contain a significant amount of water.This may mean that Nipagin A cannot readily be added directly to the formulation.Other methods of incorporation are quite straightforward however, and are listed below.Ethylparaben (ethyl para-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid. Its formula is HO-C6H4-CO-O-CH2CH3. It is a member of the class of compounds known as parabens.It is used as an antifungal preservative. As a food additive, it has E number E214.Sodium ethyl para-hydroxybenzoate, the sodium salt of ethylparaben, has the same uses and is given the E number E215. Dissolving in water The solubility of Nipagin A increases greatly as the temperature of the water rises. Therefore a concentrate may be made up by heating an appropriate quantity of water to 60- 100 °C prior to addition of Nipagin A. This concentrate may then be added to the formulation, provided that the ester concentration does not exceed its solubility in the formulation at normal ambient temperatures. Dissolving in organic solvents Nipagin A is readily soluble in polar organic solvents. Where such a solvent is already part of a formulation an Nipagin A concentrate may be made up prior to addition. If a suitable solvent is not already part of the formulation,a highly concentrated solution may be madeup e.g. 32 % in Ethanol, which would give insignificant residual levels of ethanol in the end product. Solubilisation in oils, emulsifiers etc. Nipagin A is readily soluble in lipophilic ingredients and may be introduced to a formulation by adding to the oil phase with some warming before any emulsification stage. In multiphase systems, such as emulsions, it is often advisable to use a combination of aqueous dissolution with either of the other methods to ensure adequate preservation. The ester may be incorporated in the water to its maximum solubility and any further quantities may be dissolved in the oil phase, or solvent, as appropriate. pH stability Nipagin A remains fully stable over a wide pH range from 4- 8. In general the lower the pH of the formulation, the more active is Nipagin A. That can result in a lower use concentration when the pH of the formulation is more acidic. Temperature stability Nipagin A is stable up to 80 °C Solubility The solubility of Nipagin A in different solvents is illustrated in the following table. Solvent % (w/w) Water 10 °C 0.06 Water 25 °C 0.11 Water 80 °C 0.86 Water 100 °C 1.7 Acetone 46 Methanol 45 Ethanol 41 Propylene Glycol 20 Glycerol 0.5 Vegetable oils (arachis) 1.0 Liquid paraffin 0.025 Microbial Activity Nipagin A exhibits microbiostatic activity against a wide range of bacteria, yeast and mould. This is illustrated by the following table which shows the minimum inhibitory concentration (MIC) of Nipagin A against examples of different groups of microorganisms. Microorganisms MIC level (%) Gram Negative Bacteria Pseudomonas aeruginosa 0.10 Escherichia coli 0.05 Klebsiella aerogenes 0.05 Klebsiella pneumoniae 0.05 Serratia marcescens 0.05 Proteus vulgaris 0.06 Salmonella enteritidis 0.05 Salmonella typhi 0.10 Microorganisms MIC level (%) Gram Positive Bacteria Stpahylococcus aureus 0.07 Streptococcus haemolyticus 0.06 Bacillus cereus 0.025 Bacillus subtilis 0.10 Lactobacillus buchneri 0.06 Yeasts Candida albicans 0.07 Saccharomyces cerevisiae 0.05 Molds Aspergillus niger 0.04 Penicillium digitatum 0.025 Rhizopus nigricans 0.025 Chemical Properties white crystalline powder Chemical Properties Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder. Uses An antimicrobial Uses bronchodilator, tocolytic Uses Preservative for pharmaceuticals. Production Methods Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%). Synthesis Reference(s) The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007 Pharmaceutical Applications Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations. It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives. The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline. Contact allergens This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin. Safety Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight. LD50 (mouse, IP): 0.52 g/kg LD50 (mouse, oral): 3.0 g/kg storage Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature). Ethylparaben should be stored in a well-closed container in a cool, dry place. Incompatibilities The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy. Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids. Regulatory Status Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Ethylparaben * A preservative found in skin care products, often used to treat dry skin through essential oils such as eucalyptus and primrose oil * Read the following TIA articles concerning ethylparaben and its link to cancer: Preservatives and Parabens and Are They Safe? and What Is It: Estrogen in my Shampoo Ethylparaben is a paraben and preservative found in many skin care products, ranging from skin cream to body lotion to deodorant. It can be found in essential oils used to treat dry skin and in primrose oil serving as an anti-septic. Although parabens are generally considered safe when used in low percentages (.04% - .08%), a study claimed to have found a link between parabens and breast cancer. According to the Cosmetic Ingredient Review (CIR) Expert Panel, however, "the available acute, subchronic, and chronic toxicity tests, using a range of exposure routes, demonstrate a low order of parabens' toxicity at concentrations that would be used in cosmetics" (source). After testing different levels of exposure to parabens in women, men, and children, the CIR Expert Panel found that these "determinations are conservative and likely represent an overestimate of the possibility of an adverse effect (e.g., use concentrations may be lower, penetration may be less) and support the safety of cosmetic products in which parabens preservatives are used." * A preservative found in skin care products, often used to treat dry skin through essential oils such as eucalyptus and primrose oil * Read the following TIA articles concerning ethylparaben and its link to cancer: Preservatives and Parabens and Are They Safe? and What Is It: Estrogen in my Shampoo Functions: Ethylparaben is a paraben and preservative found in many skin care products, ranging from skin cream to body lotion to deodorant. It can be found in essential oils used to treat dry skin and in primrose oil serving as an anti-septic. Although parabens are generally considered safe when used in low percentages (.04% - .08%), a study claimed to have found a link between parabens and breast cancer. According to the Cosmetic Ingredient Review (CIR) Expert Panel, however, "the available acute, subchronic, and chronic toxicity tests, using a range of exposure routes, demonstrate a low order of parabens' toxicity at concentrations that would be used in cosmetics" (source). After testing different levels of exposure to parabens in women, men, and children, the CIR Expert Panel found that these "determinations are conservative and likely represent an overestimate of the possibility of an adverse effect (e.g., use concentrations may be lower, penetration may be less) and support the safety of cosmetic products in which parabens preservatives are used." Ultimately, the cosmetics industry has found the low levels of parabens in cosmetics to be safe and the connection between parabens and breast cancer to be weak. The FDA finds that although parabens can mimic estrogen, the actual effects of this low level of activity on the body do not cause cancer in a higher incidence than naturally occurring estrogen. Nonetheless, many paraben-free products are being created to avoid the possible dangers of ethylparaben and other paraben-based preservatives. Roles Classification Biological Role(s): antimicrobial food preservative A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. phytoestrogen Any compound produced by a plant that happens to have estrogenic activity. Application(s): antimicrobial food preservative A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). Ethylparaben provides the good performance against Gram positive bacteria exhibited by all the parabens and has the same limitations regarding pH range (acidic only), system compatibility (avoid high levels of ethoxylates) and water solubility (limited). Ethylparaben has been used in combination with Propylparaben in oral preparations for controlling fermentative action. It can be used alone, but is generally used at 0.10 to 0.25% levels with other CoSepts as the antifungal portion of the preservative system. Use: Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives and antiseptic for bacteria. Use: Preservative, Cosmetics, Feed, Pharmaceutical, Soft Drink, Alcohol Beverage, Beverage Powder, Fruit Juice, Puddings, Sauces, Baking Food, Sauage, Flavoring Agent. Other names: Benzoic acid, 4-hydroxy-, ethyl ester; Benzoic acid, p-hydroxy-, ethyl ester; p-Carbethoxyphenol; p-Hydroxybenzoate ethyl ester; p-Hydroxybenzoic acid ethyl ester; Aseptoform E; Bonomold OE; Easeptol; Ethyl p-hydroxybenzoate; Ethyl parasept; Ethyl Butex; Ethyl 4-hydroxybenzoate; Mycocten; Napagin A; Nipagin A; Nipazin A; Sobrol A; Solbrol A; Tegosept E; 4-Hydroxybenzoic acid, ethyl ester; Ethyl para-hydroxybenzoate; Ester etylowykwasu p-hydroksybenzoesowego; Ethylester kyseliny p-hydroxybenzoove; Ethyl p-oxybenzoate; Nipagina A; p-Oxybenzoesaeureaethylester; 4-(Ethoxycarbonyl)phenol; 4-Carbethoxyphenol; Aseptin A; Aseptine A; Para-hydroxybenzoic acid ethyl ester; Mekkings E; NSC 23514 Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive Storage instructions The product must be stored in tighly closed container in a cool, well- ventilated, dry place. Further information on handling, storage and dispatch isgiven in the EC safety data sheet.

SILVER NITRATE, N° CAS : 7761-88-8 - Nitrate d'argent. Nom INCI : SILVER NITRATE. Nom chimique : Silver nitrate. N° EINECS/ELINCS : 231-853-9. Classification : Règlementé, Colorant capillaire. Ses fonctions (INCI). Agent colorant pour cheveux : Colore les cheveux. Noms français : Nitrate d'argent. Noms anglais : LUNAR CAUSTIC; NITRIC ACID SILVER(1+) SALT; SILVER MONONITRATE; Silver nitrate; SILVER(1+) NITRATE. Utilisation: Le nitrate d'argent trouve plusieurs applications, notamment: en photographie, dans la manufacture de miroirs, dans les encres indélébiles, en teinture de cheveux, comme antiseptique, en chromatographie, comme agent titrimétrique en chimie analytique. Argenti nitras; Argerol, gümüş nitrat, Lunar caustic, Nitric acid , silver(1+) salt (1:1), Nitric acid silver(I) salt, Nitric acid, silver(1+) salt, Silver mononitrate, Silver nitrate(DOT), Silver(1+) nitrate, Silver(I) nitrate (1:1), Azotan srebra (pl), azotan(V) srebra (pl) ; azotat de argint (ro); dusičnan strieborný (sk); dusičnan stříbrný (cs); ezüst-nitrát (hu); Ezüstnitrát (hu); Hopeanitraatti (fi); Hõbenitraat (et); Nitrat de argint (ro); Nitrat tal-fidda (mt); Nitrate d'argent (fr); Nitrato d'argento (it); Nitrato de plata (es); Nitrato de prata (pt); nitrato di argento (it); Sidabro nitratas (lt); Silbernitrat (de); Silver nitrate (no); Silvernitrat (sv); Srebrov nitrat (hr); Sudraba nitrāts (lv); sølvnitrat (da); Zilvernitraat (nl); Νιτρικός άργυρος (el); Сребърен нитрат (bg). gümüş nitrat, gümüşnitrat, : Silver Nitrate; Nitric acid silver(I) salt, Argenti nitras ;Silver nitrate concentrate; silver(1+) ion nitrate; silver(1+) ion nitrooxidane; Silver(I) nitrate; silver(I)nitrate; silver;nitrate; identifiers231-853-9 [EINECS]; 7761-88-8 [RN]; Argenti nitras [Latin]; Argenti nitras; Lunar caustic; MFCD00003414 ; [MDL number]; Nitrate d'argent [French]; Nitrate d'argent(1+) [French] [ACD/IUPAC Name]; Nitrato de plata [Spanish]; Nitric acid silver (1+) salt; nitric acid silver(I) salt; Nitric acid, silver(1+) salt ;Silber(1+)nitrat [German]; Silver nitrate ; Silver(1+) nitrate [ACD/IUPAC Name]; silver(i) nitrate; Silver(I) nitrate (1:1); Argerol; Nitric acid silver(1+) salt; Silbernitrat; silver mononitrate; Silver nitrate ACS grade; 硝酸银 [Chinese]

nitric acid; Aqua Fortis; Azotic Acid; Hydrogen nitrate; nitrous fumes; Acid Nitrique, Acido Nitroco, Acido Nitrico, Aqua Fortis, Azotic Acid, Azotowy Kwas, Engraver's Acid, Hydrogen Nitrate, Kyselina Dusicne, Nital, Nitrous Fumes, Nitryl Hydroxide, Salpetersaure, Salpeterzuuroplossingen cas no: 7697-37-2

Mononitromethane; Nitrocarbol; NM; Nitrometan (Polish); NMT; nitrometano (Spanish); Nitrométhane (French) CAS NO:75-52-5

Mononitromethane; Nitrocarbol; NM; Nitrometan (Polish); NMT; nitrometano (Spanish); Nitrométhane (French) CAS NO:75-52-5

N-Lauroylsarcosine sodium salt is a white Powder.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.


CAS Number: 137-16-6
EC Number: 205-281-5
MDL number: MFCD00042728
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Molecular Formula: C₁₅H₂₈NNaO₃


N-Lauroylsarcosine sodium salt also decreases transcription efficiency.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.
N-Lauroylsarcosine sodium salt is a white Powder


N-Lauroylsarcosine sodium salt is a sodium salt of an acyl derivative of sarcosine, which is a natural amino acid found in muscles and other body tissues.
Acyl sarcosines are considered modifiŽed fatty acids in which the hydrocarbon chains are interrupted by an amidomethyl group in the alpha position.
They are used as hair-conditioning agents and surfactant-cleansing agents in cosmetics, as well as to improve wetting and penetration of topical pharmaceutical products.


Acyl sarcosines and their sodium salts are also used in the metal finishing and processing industries for their crystal modifying, anti-rust, and anti-corrosion properties.
N-Lauroylsarcosine sodium salt is an amino acid surfactant.


A powerful anionic surfactant, N-Lauroylsarcosine sodium salt, that confers mild detergency, excellent foaming and lathering characteristics.
N-Lauroylsarcosine sodium salt displays synergy with other detergents.
N-Lauroylsarcosine sodium salt also decreases transcription efficiency.


N-Lauroylsarcosine sodium salt is an inhibitor of HXK.
N-Lauroylsarcosine sodium salt, also known as sarkosyl, is an ionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.


In molecular biology experiments, N-Lauroylsarcosine sodium salt is used to inhibit the initiation of DNA transcription.
N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH.


Addition of an mixture of equal parts of sodium lauroyl sarcosinate and the non-ionic surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone. Such aggregates can help carry other small molecules, such as drugs, through the skin.


N-Lauroylsarcosine sodium salt is a sodium salt that belongs to the group of sodium salts.
The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.


N-Lauroylsarcosine sodium salt has been shown to have biological properties such as permeability through human serum and biodegradability.
The salt form of N-Lauroylsarcosine sodium salt has an electrochemical impedance spectrum which can be used to identify it.
N-Lauroylsarcosine sodium salt is a Suggested storage of Sodium lauroyl sarcosinate: Store in tightly closed containers in a cool, dry, and well-ventilated area away from oxidizing agents and sources of ignition; ground all equip. containing this material 25 C


N-Lauroylsarcosine sodium salt is an anionic surfactant with an ability to denature proteins.
Due to its microbicidal property, N-Lauroylsarcosine sodium salt is being considered as a potent anti-microbicide in topical formulations, especially against sexually transmitted diseases (STDs).


N-Lauroylsarcosine sodium salt is non flammable.
N-Lauroylsarcosine sodium salt, also known as sarkosyl, is a white powder derived from sarcosine, which make it is fate-free and biodegradable.
N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.


N-Lauroylsarcosine sodium salt, the English name is SODIUMLAUROYLSARCOSINATE, alias: sodium lauroyl-N-methylaminoacetate, sodium dodecanoyl-N-methyl glycinate.
N-Lauroylsarcosine sodium salt is safe to use and generally has no effect on pregnant women.


N-Lauroylsarcosine sodium salt is a white powder.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.
N-Lauroylsarcosine sodium salt is an anionic detergent.


N-Lauroylsarcosine sodium salt, also known as sarkosyl, is an ionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.
N-Lauroylsarcosine sodium salt is an anionic surfactant which also has protein denaturant potency.



USES and APPLICATIONS of N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt is used as a detergent, foaming agent, and antienzyme for dentifrices.
N-Lauroylsarcosine sodium salt is permitted for use as an inert ingredient in non-food pesticide products.
N-Lauroylsarcosine sodium salt, also known as sarkosyl, is an ionic surfactant derived from sarcosine, used as a foaming and cleansing agent in shampoo, shaving foam and foam wash products.


In molecular biology experiments, N-Lauroylsarcosine sodium salt is used to inhibit the initiation of DNA transcription.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.
N-Lauroylsarcosine sodium salt is a high quality research product used as multipurpose anionic surfactant widely used in the biochemistry of protein extraction and purification.


N-Lauroylsarcosine sodium salt has been especially used with membrane proteins.
N-Lauroylsarcosine sodium salt is used multipurpose anionic surfactant widely used in the biochemistry of protein extraction and purification.
N-Lauroylsarcosine sodium salt has been especially used with membrane proteins.


N-Lauroylsarcosine sodium salt (stabilised) is used for synthesis.
In addition to its excellent surface activity, N-Lauroylsarcosine sodium salt also has antibacterial and bactericidal properties, corrosion and rust resistance, and good biodegradability.


N-Lauroylsarcosine sodium salt is used Food and beverage, metal rust prevention, mineral flotation, pesticides and biomedicine and many other fields.
In terms of mineral flotation, N-Lauroylsarcosine sodium salt has a good synergy with cationic surfactants to achieve higher flotation efficiency, and is a new type of amino acid anionic surfactant.


N-Lauroylsarcosine sodium salt has the characteristics of washing, emulsifying, penetrating and solubilizing;
Excellent foamability, and the foam is delicate and long-lasting.
N-Lauroylsarcosine sodium salt is suitable as a raw material for toothpaste and cosmetic foam, shampoo, shaving cream;


N-Lauroylsarcosine sodium salt is used Foaming and cleansing agent for shampoos; mild to skin and hair.
N-Lauroylsarcosine sodium salt is used Wetting agent.
N-Lauroylsarcosine sodium salt is used enzyme inhibitor in oral care.


N-Lauroylsarcosine sodium salt is used Corrosion inhibitor.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.


N-Lauroylsarcosine sodium salt uses and applications include: Foam builderstabilizer, wetting agent, detergent, lubricant, antistat, corrosion inhibitor, bacteriostat, penetrant in dentals, pharmaceuticals, surgical scrubs, shampoos, depilatories, shaving preparations, food packaging, householdindustrial cleaners, froth flotation, textileleather processing, emulsion polymerization; antistat, surfactant, viscous control agent in cosmetics.


N-Lauroylsarcosine sodium salt is used anti-enzyme for dentifrices; in food packaging adhesives; and in vinylidene coatings for food-contact cellophane.
N-Lauroylsarcosine sodium salt is used Paint, ink additives, increase compatibility and stability.
N-Lauroylsarcosine sodium salt is used Corrosion inhibitor and rust remover in metal processing.


N-Lauroylsarcosine sodium salt is used in medicine as a solvent for cell purification.
N-Lauroylsarcosine sodium salt is an anionic surfactant, especially suitable for the preparation of shampoo, bath liquid, cleansing milk, baby detergent, tableware detergent and so on.


N-Lauroylsarcosine sodium salt is used in medicine as a solvent for cell purification.
N-Lauroylsarcosine sodium salt is a surfactant that is used in water treatment, wastewater treatment, and as a detergent.
N-Lauroylsarcosine sodium salt is also used as an analytical tool for the titration calorimetry of sodium salts.


N-Lauroylsarcosine sodium salt is personal care products as well as in household and industrial applications, and it is used as a co-surfactant in cleanser formulations such as shampoos and body washes.
N-Lauroylsarcosine sodium salt can also be used in oral care applications such as toothpastes and incorporated into syndet and combo bars.


The typical usage levels range of N-Lauroylsarcosine sodium salt from 1-5% on an active basis.
N-Lauroylsarcosine sodium salt is mild, biodegradable anionic surfactants derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products. N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.


N-Lauroylsarcosine sodium salt is a high foam, eco-friendly surfactant.
N-Lauroylsarcosine sodium salt has good chlorine stability with anti-corrosion properties.
N-Lauroylsarcosine sodium salt has excellent ocular tolerance and gentleness.


N-Lauroylsarcosine sodium salt is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent.
N-Lauroylsarcosine sodium salt has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged.


N-Lauroylsarcosine sodium salt also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away.
As a modified fatty acid, N-Lauroylsarcosine sodium salt is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.


N-Lauroylsarcosine sodium salt is used Detergent, foaming agent, and antienzyme for dentifrices.
N-Lauroylsarcosine sodium salt is suitable for solubilization and separation of membrane proteins, lysis of cells during the isolation of RNA, and inhibition of hexokinase.


N-Lauroylsarcosine sodium salt is mainly used in cosmetics and skincare products as an anti-static, foaming agent, detergent, and surfactant.
N-Lauroylsarcosine sodium salt is an amino acid surfactant with excellent surface activity, antibacterial and bactericidal properties, corrosion and rust inhibition and good biodegradability, etc.


N-Lauroylsarcosine sodium salt is therefore widely used in many fields such as detergents, cosmetics, food and beverage, metal rust prevention, mineral flotation, pesticides, and biological medicine.
N-Lauroylsarcosine sodium salt is used usage Biochemical research.


N-Lauroylsarcosine sodium salt is used anionic surfactants.
N-Lauroylsarcosine sodium salt is used hexokinase inhibitor.
N-Lauroylsarcosine sodium salt is used Anionic detergent.


N-Lauroylsarcosine sodium salt is used Separation of yeast ribonucleic acid.
N-Lauroylsarcosine sodium salt can be used for RNA and DNA isolation, as a lysing agent in cell purification, as an additive in the isolation of DNA from human serum, and to increase the nitrogen fixation capacity of legume rhizobia by adding this product, and has many applications in immunochemistry.


N-Lauroylsarcosine sodium salt can be used in RNA extraction protocols for cell lysis because it does not produce excessive foam.
N-Lauroylsarcosine sodium salt, also known as sarcosyl, is an anionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.


N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).


N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.
N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungistatic agent in aqueous dispersion (1%).
N-Lauroylsarcosine sodium salt is used Cell Lysis Reagent | Electrophoresis Chromatography | Detergents.


N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.


N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungistatic agent in aqueous dispersion (1%).
N-Lauroylsarcosine sodium salt, Ultrapure is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt has been used as one of the components of the lysing solution in the cornet assay.


N-Lauroylsarcosine sodium salt has been used for lysing protoplasts in the process of chromosomal DNA isolation form Streptococcus mutans.
In molecular biology experiments, N-Lauroylsarcosine sodium salt is used to inhibit the initiation of DNA transcription.
N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.


Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH.
The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.


Addition of an mixture of equal parts of N-Lauroylsarcosine sodium salt and the non-ionic surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone.
Such aggregates can help carry other small molecules, such as drugs, through the skin.


Cosmetic Uses of N-Lauroylsarcosine sodium salt: antistatic agents, cleansing agents, foaming agents, hair conditioning, skin conditioning, surfactants, surfactant - emulsifying, and viscosity controlling agents.



BIOCHEM/PHYSIOL ACTIONS OF N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt is an anionic surfactant which also has protein denaturant potency.
In addition, N-Lauroylsarcosine sodium salt has been shown as a microbicide for sexually transmitted diseases.



IN CULTURE, N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt was sold as a special ingredient called "Gardol" in Colgate "Dental Cream", as toothpaste was then called, during the 1950s through the mid-1960s in the US and the mid-1970s in France.
N-Lauroylsarcosine sodium salt's current use as a preventive dentifrice is in Arm & Hammer Baking Soda Toothpaste, a Church & Dwight product, where it is used as a surfactant.



PHYSICAL and CHEMICAL PROPERTIES of N-LAUROYLSARCOSINE SODIUM SALT:
Molecular Formula: C₁₅H₂₈NNaO₃
Appearance: White to Off-White Solid
Melting Point:147-150°C
Molecular Weight: 293.38
Storage: 4°C
Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
Molecular Weight: 294.39
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 12
Exact Mass: 294.20451307
Monoisotopic Mass: 294.20451307
Topological Polar Surface Area: 57.6 Ų
Heavy Atom Count: 20
CAS ID: 137-16-6
Density: 1.14 g/cm3 (20 °C)
Flash point: 267 °C
Melting Point: 146 °C
pH value: 8 (30 g/l, H₂O, 20 °C)
Vapor pressure: 0.02 hPa (20 °C)
Bulk density: 400 kg/m3

IUPAC Name: sodium;2-[dodecanoyl(methyl)amino]acetate
Molecular Weight: 293.38 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 12
Exact Mass: 293.19668804 g/mol
Monoisotopic Mass: 293.19668804 g/mol
Topological Polar Surface Area: 60.4Ų
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 260
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
Molecular Formula: C15H28NNaO3
Molecular Weight: 293.3827693
SMILES: CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
CAS Min %: 94
CAS Max %: 100

Melting Point: 45.0°C to 47.0°C
Color: White
pH: 7.0 to 9.0
Loss on Drying: 7% max. ()
Infrared Spectrum: Authentic
Linear Formula: NaCO2CH2N(CH3)CO(CH2)10CH3
Merck Index: 154401
Solubility Information: (10% in water) Almost clear colorless to light yellow
Formula Weight: 293.39
Percent Purity: 95%
Physical Form: Solid
Chemical Name or Material: N-Lauroylsarcosine sodium salt
Formal Charge: 0
Complexity: 254
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
IUPAC Name: sodium2-[dodecanoyl(methyl)amino]acetate
Canonical SMILES: CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
InChI: InChI=1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)/q+1/p-1
InChI Key: KSAVQLQVUXSOCR-UHFFFAOYSA-M

Boiling Point: 100ºC
Melting Point: 140ºC
Flash Point: 94ºC (30%)
Purity: 95%
Density: 1.033 g/mL at 20 °C
Solubility: water, 6490 mg/L @ 25 °C (est)
Appearance: Clear liquid
pH: 7.0-8.5
Assay: ≥95.0%
Appearance: White crystalline powder
Volatility: ≤5.0%
Color: White
Melting Point: 44°C to 47°C
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Beilstein: 5322974
Merck Index: 14,4368
Solubility Information: Soluble in water (293g/L).
Sensitivity: Hygroscopic
Formula Weight: 293.38
Physical Form: Crystalline Powder
Beilstein Registry Number: 5322974
CAS #: 137-16-6
Critical Micelle Concentration: 14.57 mM at 30 °C(Lit.)

EC Number: 205-281-5
Extinction Coefficient: EM = 3 (280 nm)(Lit.)
Flash Point: 267 °C / 512.6 °F (lit.)
Format: Powder
Hazard Statements: H315-H318-H330
Molecular Formula: C15H28NO3 • Na
Molecular Weight: 293.4
pH: 7.5 - 8.5 (10% aqueous solution)
Purity: >95.5%
Safety Symbol: GHS05, GHS06
Solubility: Soluble in water (100 mg/mL - clear to slightly hazy, colorless solution).
Density: 1.033 g/mL at 20 °C
Boiling Point: 100ºC
Melting Point: 46 °C
Molecular Formula: C15H28NNaO3
Molecular Weight: 293.378
Exact Mass: 293.196686
PSA: 60.44000
LogP: 2.11560
Storage condition: room temp
Stability: Stable.
Water Solubility: H2O: 1 M at 20 °C, clear, colorless
Appearance Form: powder

Colour: white
Odour: No data available
Odour Threshold: No data available
pH: 7,0 - 9 at 293 g/l at 25 °C
Melting point/freezing point: 146,1 °C at 1.013 hPa
Initial boiling point and boiling range: 350 - 410 °C at 1.013 hPa
CAS NUMBER: 137-16-6
MOLECULAR FORMULA: C15H28NO3 • Na
MOLECULAR WEIGHT: 293.4
BEILSTEIN REGISTRY NUMBER: 5322974
EC NUMBER: 205-281-5
MDL NUMBER: MFCD00042728
Molecular Weight: 293.4
Molecular Formula: C15H28NO3Na
InChI: InChI=1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1
InChI Key: KSAVQLQVUXSOCR-UHFFFAOYSA-M
Melting Point: 46 °C
Flash Point: 267 °C
Density: 1.033 g/mL at 20 °C
Solubility: Ethanol: slightly soluble; Methanol: slightly soluble; PBS (pH 7.2): slightly soluble
Appearance: Solid
Complexity: 260
EC Number: 205-281-5

Exact Mass: 293.19668804
Formal Charge: 0
Hazard Statements: Xi,T
Heavy Atom Count: 20
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 0
Isomeric SMILES: CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
MDL Number: MFCD00042728
Monoisotopic Mass: 293.19668804
pH: 7.0-9.0 (1M in H₂O, 25 °C)
Rotatable Bond Count: 12
Safty Description: 22-24/25-36/37/39-27-26-45-38-37/39
Shipping: Room temperature
Stability: ≥2 years
Supplemental Hazard Statements: H315-H318-H330-H319-H332
Symbol: GHS05,GHS06,GHS07
Topological Polar Surface Area: 60.4 Ų
Flash point: 267 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapour pressure: 0,02 hPa at 20 °C
Vapour density: No data available
Relative density: 1,141 g/cm3 at 20 °C

Water solubility: 293 g/l at 20 °C - completely soluble
Melting point: 46 °C
Density: 1.033 g/mL at 20 °C
vapor pressure: 0.02 hPa (20 °C)
RTECS: MC0598960
Flash point: 267℃
storage temp.: room temp
solubility: H2O: 1 M at 20 °C, clear, colorless
form: Powder
Specific Gravity: 1.03 (20/4℃)
color: White
Odor: at 100.00?%. bland
PH: 7.0-9.0 (25℃, 1M in H2O)
Water Solubility: Soluble in water (293 g/L).
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.06
Merck: 14,4368
BRN: 5322974
Stability: Stable.
LogP: 0.37
UN Number: 2811
Formula Weight: 293.38
Physical Form: Crystal-Powder at 20°C
Percent Purity: ≥98.0% (N)

Color: White
Melting Point: 46°C
pH: 8.0 to 9.5 (50g/L H2O 25°C)
Chemical Name or Material: Sodium N-Lauroylsarcosinate
Molecular Formula / Molecular Weight: C15H28NNaO3 = 293.38
Physical State (20 deg.C): Solid
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Hygroscopic
CAS RN: 137-16-6
Reaxys Registry Number: 5322974
PubChem Substance ID: 87571989
Merck Index (14): 4368
MDL Number: MFCD00042728
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 46.00 °C. @ 760.00 mm Hg
Boiling Point: 413.00 to 414.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 399.00 °F. TCC ( 203.70 °C. ) (est)
logP (o/w): 4.328 (est)
Soluble in: water, 6490 mg/L @ 25 °C (est)



FIRST AID MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Description of first aid measures:
*General advice:
Consult a physician.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.



ACCIDENTAL RELEASE MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-LAUROYLSARCOSINE SODIUM SALT:
-Control parameters:
--Components with workplace control parameters:
-Exposure controls:
--Appropriate engineering controls:
Avoid contact with skin, eyes and clothing.
Wash hands before breaks and immediately after handling the product.
--Personal protective equipment:
*Eye/face protection:
Face shield and safety glasses.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.



HANDLING and STORAGE of N-LAUROYLSARCOSINE SODIUM SALT:
-Precautions for safe handling:
Ensure all equipment is electrically grounded before beginning transfer operations.
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
-Specific end use(s):
No other specific uses are stipulated



STABILITY and REACTIVITY of N-LAUROYLSARCOSINE SODIUM SALT:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.



SYNONYMS:
Sodium N-Lauroyl Sarcosinate
N-Lauroylsarcosine Sodium Salt
Sodium 2-(N-Methyldodecanamido)acetate
Sodium Lauroylsarcosinate
N-Dodecanoyl-N-methylglycine Sodium Salt
N-Dodecanoylsarcosine Sodium Salt
N-Lauroyl-N-methylglycine Sodium Salt
Lauroylsarcosine (sodium)
n-Lauroylsarcosine sodium salt hydrate
SCHEMBL23450
AKOS024386303
N-Lauroylsarcosine sodium salt, >=94%
2-[dodecanoyl(methyl)amino]ethanoic acid; sodium
2-[methyl(1-oxododecyl)amino]acetic acid; sodium
A807204
N-Lauroylsarcosine sodium salt, >=97.0% (HPLC)
N-Lauroylsarcosine sodium salt, BioXtra, >=97% (TLC)
N-Lauroylsarcosine sodium salt, SAJ first grade, >=96.0%
N-Lauroylsarcosine sodium salt, detergent for use in cell lysis
N-Lauroylsarcosine sodium salt, Vetec(TM) reagent grade, 94%
N-Lauroylsarcosine sodium salt solution, 20%, for molecular biology
Sodium lauroylsarcosinate, EuropePharmacopoeia (EP) Reference Standard
N-Lauroylsarcosine sodium salt solution, 30% aqueous solution, >=97.0% (HPLC)
N-Lauroylsarcosine sodium salt, BioUltra, for molecular biology, >=99.0% (HPLC)
N-Lauroylsarcosine sodium salt
Glycine, N-methyl-N- (1-oxododecyl)-, sodium salt
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
N-Dodecanoyl-N-methylglycine sodium salt
N-Methyl-N-(1-oxododecyl)glycine Sodium Salt
Sarcosine, N-lauroyl-, sodium salt
Sarcosyl
Sarcosyl NL
Sarkosyl NL
Sodium [dodecanoyl(methyl)amino]acetate
Sodium 2-(N-methyldodecanamido)acetate
SODIUM LAUROYL SARCOSINATE
Sodium lauroylsarcosinate
Sodium N-dodecanoyl-N-methylglycinate
SODIUM N-LAUROYL SARCOSINATE
Sodium N-lauroylsarcosinate
[137-16-6] [RN]
2-(N-methyldodecanoylamino)acetic acid, sodium salt
EINECS 205-281-5
Gardol
Gardol?
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Hamposyl L-30
Lauroylsarcosine sodium salt
Lauroylsarcosine, Sodium Salt - CAS 137-16-6 - Calbiochem
Maprosyl 30
Medialan LL-99
N-Dodecanoyl-N-methylglycine, sodium salt
N-Dodecanoyl-N-methylglycinesodium salt
N-Dodecanoylsarcosine Sodium Salt
N-LAUROYL-N-METHYLGLYCINE SODIUM SALT
N-Lauroylsarcosine sodium saltmissing
N-Lauroylsarcosine, sodium
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosinesodium salt
N-Lauryl sarcosine sodium salt
N-Methyl-N-(1-oxododecyl)glycine, sodium salt
Sarcosine, N-lauroyl-, sodium salt (8CI)
Sarcosyl, Sodium lauroylsarcosinate
Sarkosyl
sodium 2-(dodecanoyl-methylamino)acetate
sodium 2-(dodecanoyl-methyl-amino)acetate
sodium 2-(dodecanoyl-methyl-amino)ethanoate
sodium 2-(lauroyl-methyl-amino)acetate
sodium 2-(methyl-(1-oxododecyl)amino)acetate
Sodium lauroylsarcosine
Sodium N-Lauroylsarcosinate
N-Dodecanoylsarcosine Sodium Salt
N-Lauroylsarcosine Sodium Salt
SODIUM N-LAUROYLSARCOSINE
sodium[dodecanoyl(methyl)amino]acetate
Sarkosyl NL-97
Sodium N-Lauroyl Sarcosinate
N-Methyl-N-(1-oxododecyl) glycine sodium salt
N-Dodecanoyl-N-methylglycine sodium salt
Sarkosyl NL
N-Dodecanoylsarcosine Sodium Salt
N-Lauroylsarcosine Sodium Salt
Sodium N-Dodecanoylsarcosinate
Sodium N-Dodecanoyl-N-methyl-glycinate
Sarcosyl
Sodium N-Lauroyl Sarcosinate
Sarkosyl NL
Sarcosyl
Sarcosyl NL-30
Sodium N-Lauroylsarcosinate
Sodium N-Dodecanoylsarcosinate
N-Dodecanoylsarcosine Sodium Salt
137-16-6
Sodium lauroylsarcosinate
Sodium N-lauroylsarcosinate
N-Lauroylsarcosine sodium salt
Sarkosyl NL
Sodium lauroyl sarcosinate
Sarkosyl
Gardol
Medialan LL-99
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Sarcosyl NL
Maprosyl 30
Compound 105
Hamposyl L-30
Sarcosyl NL 30
Sarkosyl NL 30
Sarkosyl NL 35
Sarkosyl NL 97
Sarkosyl NL 100
Sodium lauroylsarcosine
MFCD00042728
Sodium N-dodecanoyl-N-methylglycinate
Sodium N-lauroylsarcosine
N-Lauroylsarcosine, sodium
Lauroylsarcosine sodium salt
sodium lauroyl sarcosine
N-Lauroylsarcosine, sodium salt
n-lauryl sarcosine sodium salt
Lauroylsarcosine (sodium)
DTXSID0027066
N-Dodecanoyl-N-methylglycine, sodium salt
sodium 2-(N-methyldodecanamido)acetate
sodium [dodecanoyl(methyl)amino]acetate
632GS99618
Sarcosine, N-lauroyl-, sodium salt
Sodium N-Dodecanoylsarcosinate
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
N-Dodecanoylsarcosine Sodium Salt
Caswell No. 778B
Lauroylsarcosine (sodium salt)
NSC-117874
SODIUM N-LAUROYL SARCOSINATE
EINECS 205-281-5
EPA Pesticide Chemical Code 000174
NSC 117874
N-Dodecanoyl-N-methylglycine sodium salt
UNII-632GS99618
starbld0009501
GARDOL [MI]
MEDIALAN LL-33
N-Lauroylsarcosine-S-salt
EC 205-281-5
N-Methyl-N-(1-oxododecyl)glycine, sodium salt
SCHEMBL23451
Lauroylsarcosine, Sodium Salt
DTXCID907066
N-Methyl-N-(1-oxododecyl)glycine sodium salt (1:1)
CHEMBL1903482
KSAVQLQVUXSOCR-UHFFFAOYSA-M
SODIUM LAUROYL SARCOSINE 1KG
Tox21_202996
AKOS015901704
SODIUM LAUROYL SARCOSINATE [II]
NCGC00164323-01
NCGC00260541-01
SODIUM LAUROYL SARCOSINATE [INCI]
AS-81025
CAS-137-16-6
SODIUM LAUROYL SARCOSINATE [VANDF]
sodium;2-[dodecanoyl(methyl)amino]acetate
HY-125920
SODIUM LAUROYL SARCOSINATE [USP-RS]
CS-0103267
FT-0631797
L0019
S0597
E81236
A934513
Q309660
W-108241
N-methyl-N-(1-oxododecyl)-glycine, monosodium salt
Sarkosyl
SDDS
Sodium lauroyl sarcosinate
Sodium N-dodecanoyl Sarcosinate
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
Sarcosine, N-lauroyl-, sodium salt
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Compound 105
Gardol (antiseptic)
N-Lauroylsarcosine sodium
Medialan LL 99
Sarkosyl NL
Sarkosyl NL 100
Sodium lauroylsarcosine
Sodium N-lauroylsarcosinate
Sarkosyl NL 97
Sarkosyl NL 30
Sodium N-lauroylsarcosine
Gardol
N-Dodecanoyl-N-methylglycine sodium salt
Sarkosyl NL 35
N-Lauroylsarcosine sodium salt
Sodium Lauroyl Sarcosinate
Maprosyl 30
Lauroylsarcosine sodium salt
Lauroyl sarcosine sodium
Secosyl
Hamposyl L 30
Nikkol Sarcosinate LN
Sarcosinate LN
Sarcosinate LN 3
Firet L
Hamposyl L 95
N-Lauroyl-N-methylglycine sodium salt
Soypon SLP
Nikkol Sarcosinate LN 3
Oramix L 30
GM 9011
N-Dodecanoylsarcosine sodium salt
Sarkosyl
Enagicol L 30N
Soypon SLE
Sarcosinate LN 30
Medialan LD
Protelan LS 9011
Crodasinic LS 95
Perlastan L 30
Nikkol Sarcosine Na
SKL
SKL (salt)
Crodasinic LS 30
Neoscoap SLN 100
Nikkol Sarcosinate LN 30
Crodasinic LS 30NP
Maprosyl 30B
FS 701
Nikkol Sarcosinates LN
Surfacare L 30
LS 30 (surfactant)
PUJI AS02-30
AS 02-30
Amin LS 30NP
Ucefactant LS 30N
Crodasinic LS 40
LS 30
Aminosyl L 30
SP Crodasinic LS 30NP-MBAL-LQ-RB
SARKOSYL
SARCOSYL
N-Methylglycinol
N-LAUROYLSARCOSINE SODIUM SALT
GARDOL
SODIUM LAUROYL SARCOSINE
LAUROYLSARCOSINE, SODIUM SALT
N-methyl-N-(1-oxodecyl)glycine sodium salt
auroyL
GardolR
Sodium N-Lauroyl Sarcosinate
N-Lauroylsarcosine sodium salt
N-Methylglycinol
Sarkosyl
SODIUM LAUROYL SARCOSINATE
sodium [dodecanoyl(methyl)amino]acetate
glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
sodium 2-(decanoyl-methyl-amino)acetate
sodium N-lauroylsarcosinate
Glycine,N-methyl-N-(1-oxododecyl)-,sodiumsalt
n-methyl-n-(1-oxododecyl)-glycinsodiumsalt
n-methyl-n-(1-oxododecyl)glycine sodium salt
N-LAURYL SARCOSINE, SODIUM SALT
N-LAUROYLSARCOSINE NA-SALT
N-LAUROYLSARCOSINE SODIUM SALT
N-LAUROYLSARCOSINE SODIUM SALT HYDRATE
N-DODECANOYL-N-METHYLGLYCINE SODIUM SALT
Sodium lauroylsarcosinate
Sodium lauroyl sarcosinate
N-Lauroylsarcosine, sodium salt
N-Methyl-N-(1-oxododecyl) glycine, sodium salt
Sodium-N-dodecanoyl-N-methylglycinate
Sodium N-lauroyl sarcosinate

N-Lauroylsarcosine sodium salt is an anionic surfactant.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.


CAS Number: 137-16-6
EC Number: 205-281-5
MDL number: MFCD00042728
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Molecular Formula: C15H28NNaO3



N-lauroylsarcosine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, Sarcosyl, Sodium N-dodecanoyl-N-methylglycinate, Sodium N-Dodecanoyl-N-methyl-glycinate , Sarcosyl , Sodium N-Lauroyl Sarcosinate , Sarkosyl NL, Sarkosyl NL-97, Sodium N-Lauroyl Sarcosinate, N-Methyl-N-(1-oxododecyl) glycine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, sarkosyl nl, sodium lauroyl sarcosinate, n-lauroylsarcosine sodium salt, sodium n-lauroylsarcosinate, sodium lauroylsarcosinate, sarcosyl nl, maprosyl 30, compound 105, gardol, hamposyl l-30, Sodium N-Dodecanoyl-N-methyl-glycinate , Sarcosyl , Sodium N-Lauroyl Sarcosinate , Sarkosyl NL, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, Sarkosyl NL-97, Sodium N-Lauroyl Sarcosinate, N-Methyl-N-(1-oxododecyl) glycine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, Sodium lauroyl sarcosinate,



N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.
N-Lauroylsarcosine sodium salt also decreases transcription efficiency.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.


N-Lauroylsarcosine sodium salt is an anionic surfactant.
N-Lauroylsarcosine sodium salt is soluble in water (293 g/L).
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.


N-Lauroylsarcosine sodium salt is used multipurpose anionic surfactant widely used in the biochemistry of protein extraction and purification.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins
N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase.


N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.
N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).


N-Lauroylsarcosine sodium salt is soluble in water (293 g/L).
N-Lauroylsarcosine sodium salt is an anionic detergent.
N-Lauroylsarcosine sodium salt is an anionic surfactant.



USES and APPLICATIONS of N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt has been used in a study to assess involvement of histamine released from epidermal keratinocytes.
N-Lauroylsarcosine sodium salt has also been used in a study to develop a simple method for extracting DNA from Cryptosporidium oocysts.
N-Lauroylsarcosine sodium salt is used cell Lysis Reagent | Electrophoresis Chromatography | Detergents


N-Lauroylsarcosine sodium salt has been especially used with membrane proteins.
Key Applications of N-Lauroylsarcosine sodium salt: Cell Lysis Reagent | Electrophoresis Chromatography | Detergents
N-Lauroylsarcosine sodium salt is used in a study to assess involvement of histamine released from epidermal keratinocytes.


N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt has been used as one of the components of the lysing solution in the cornet assay.
N-Lauroylsarcosine sodium salt has been used for lysing protoplasts in the process of chromosomal DNA isolation form Streptococcus mutans.


N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoprotein′s; reported to inhibit hexokinase.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.


N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).
N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).



NOTES OF N-LAUROYLSARCOSINE SODIUM SALT:
Hygroscopic, store N-Lauroylsarcosine sodium salt away form water/moisture.
Store N-Lauroylsarcosine sodium salt in cool.
Keep N-Lauroylsarcosine sodium salt container tightly closed in a dry and well-ventilated place.
Store N-Lauroylsarcosine sodium salt away from oxidizing agent and reducing agent.



BIOCHEM/PHYSIOL ACTIONS OF N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt is an anionic surfactant which also has protein denaturant potency.
In addition, N-Lauroylsarcosine sodium salt has been shown as a microbicide for sexually transmitted diseases.



PHYSICAL and CHEMICAL PROPERTIES of N-LAUROYLSARCOSINE SODIUM SALT:
CAS Number: 137-16-6
Molecular Weight: 293.38
Beilstein: 5322974
EC Number: 205-281-5
MDL number: MFCD00042728
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Melting Point: 44°C to 47°C
Color: White
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Beilstein: 5322974
Sensitivity: Hygroscopic
Merck Index: 14,4368
Solubility Information: Soluble in water (293g/L).

Formula Weight: 293.38
Percent Purity: 95%
Physical Form: Crystalline Powder
Chemical Name or Material: N-Lauroylsarcosine sodium salt
Physical state: powder
Color: white
Odor: characteristic
Melting point/freezing point:
Melting point: 146 °C
Initial boiling point and boiling range: 350 - 410 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 267 °C - closed cup

Autoignition temperature: No data available
Decomposition temperature: No data available
pH: ca.8 at 30 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility at 20 °C soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 0,02 hPa at 20 °C
Density: 1,14 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available

Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
CAS NUMBER: 137-16-6
MOLECULAR FORMULA: C15H28NO3 • Na
MOLECULAR WEIGHT: 293.4
BEILSTEIN REGISTRY NUMBER: 5322974
EC NUMBER: 205-281-5
MDL NUMBER: MFCD00042728
CAS Min %: 94
CAS Max %: 100
Melting Point: 45.0°C to 47.0°C

Color: White
pH: 7.0 to 9.0
Loss on Drying: 7% max. ()
Infrared Spectrum: Authentic
Assay Percent Range: 0.95
Linear Formula: NaCO2CH2N(CH3)CO(CH2)10CH3
Merck Index: 154401
Solubility Information (10% in water): Almost clear colorless to light yellow
Formula Weight: 293.39
Percent Purity: 95%
Physical Form: Solid
Chemical Name or Material: N-Lauroylsarcosine sodium salt



FIRST AID MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Description of first-aid measures:
No data available
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Environmental precautions:
No data available
-Methods and materials for containment and cleaning up:
No data available



FIRE FIGHTING MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Extinguishing media:
No data available
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-LAUROYLSARCOSINE SODIUM SALT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Prevent product from entering drains.



HANDLING and STORAGE of N-LAUROYLSARCOSINE SODIUM SALT:
-Conditions for safe storage, including any incompatibilities:
hygroscopic
Store under inert gas.



STABILITY and REACTIVITY of N-LAUROYLSARCOSINE SODIUM SALT:
-Reactivity:
No data available
-Chemical stability:
No data available
-Conditions to avoid:
No data available
-Incompatible materials:
No data available

1-Methylpyrrolidine; Methylpyrrolidine; N-Methyltetrahydropyrrole CAS NO. 120-94-5

N-methyl 2-pyrrolidone (NMP) is almost colorless liquid with an amine odor.
N-methyl 2-pyrrolidone (NMP) is a solvent used in a range of products.
N-methyl 2-pyrrolidone (NMP) is chemically and thermally stable, and not corrosive.


CAS Number: 872-50-4
EC Number: 212-828-1
MDL number: MFCD00003193
Chemical formula: C5H9NO



SYNONYMS:
1-Methylpyrrolidin-2-one, 1-Methyl-2-pyrrolidone, N-Methylpyrrolidone, N-Methylpyrrolidinone, Pharmasolve, 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP, 1-METHYL-2-PYRROLIDINONE, 872-50-4, N-Methylpyrrolidone, N-Methyl-2-pyrrolidone, 1-methylpyrrolidin-2-one, Methylpyrrolidone, N-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, M-Pyrol, Methyl pyrrolidone, 1-Methylpyrrolidone, 1-Methylpyrrolidinone, N-Methylpyrrolidinone, n-methyl-pyrrolidone, 2-Pyrrolidinone, 1-methyl-, 1-Methyl-5-pyrrolidinone, 1-Methylazacyclopentan-2-one, NMP, N-methylpyrrolidin-2-one, N-Methyl-gamma-butyrolactam, N-methyl pyrrolidone, pharmasolve, 1-methylpyrrolidine-2-one, N-methyl pyrrolidinone, Methyl-2-pyrrolidinone, 1-methyl-2-pyrrolidon, Methylpyrrolidinone, Agsolex 1, 2-Pyrrolidinone, methyl-, 2687-44-7, N-Methyl-alpha-pyrrolidone, N-Methyl-alpha-pyrrolidinone, NSC 4594, CCRIS 1633, Methylpyrrolidone [NF], N-Methylpyrrolid-2-one, 51013-18-4, DTXSID6020856, HSDB 5022, UNII-JR9CE63FPM, JR9CE63FPM, NSC-4594, Pyrol M, EINECS 212-828-1, Microposit 2001, CHEBI:7307, 26138-58-9, AI3-23116, 1-methyl-2-pyrolidinone, MFCD00003193, 1-methyl-pyrrolidin-2-one, N-Methyl-.alpha.-pyrrolidone, CHEMBL12543, DTXCID60856, N-Methyl-.gamma.-butyrolactam, N-Methyl-.alpha.-pyrrolidinone, NSC4594, EC 212-828-1, N 0131, 1-Methyl-2-pyrrolidinone, HPLC Grade, SL 1332, M 0418, METHYL PYRROLIDONE (II), METHYL PYRROLIDONE [II], METHYLPYRROLIDONE (USP-RS), METHYLPYRROLIDONE [USP-RS], N-METHYLPYRROLIDONE (MART.), N-METHYLPYRROLIDONE [MART.], N-METHYLPYRROLIDONE (USP-RS), N-METHYLPYRROLIDONE [USP-RS], N-Methylpyrrolidon, CAS-872-50-4, N-METHYLPYRROLIDONE (EP MONOGRAPH), N-METHYLPYRROLIDONE [EP MONOGRAPH], N-methyl-pyrrolidinone, N-Methylpyrrolidone; 1-Methylpyrrolidin-2-one, Methylpyrrolidone, N-, Pyrrolidinone, methyl-, N-Methyl-2-pyrrolidon, 1-methyl-2-pyrolidone, N-methyl-pyrrolidin-2-one, 1-Methyl-2-pyrrolidinone, puriss. p.a., >=99.0% (GC), Micropure ultra, N-methylpyrolidinone, N-methypyrrolidone, Max-1 peptide, N-methylpirrolidone, 1methylpyrrolidinone, n-methyl pyrrolidon, N-methy pyrrolidone, N-methyl-pyrolidone, N-methyl-pyrollidone, N-methylpyrrolidone, 1-methylpyrolidinone, n-methylpyrollidinone, N-Methylpyrrolidione, N-methlypyrrolidinone, N-methyl pirrolidone, N-methyl pyrollidone, N-methyl-pyrollidone, N-methylpyrrolidone-, NMP,SP Grade, 1-methyl pyrrolidone, 1-methyl-pyrrolidone, methyl-2-pyrrolidone, N-methy pyrrolidinone, N-methyl pyrolidinone, N-methyl-p, 1-Methylazacyclopentane-2-one, GTPL9520, 1-Methyl-2-pyrrolidin-2-one, 1-methyl-2-pyrrolidinone (nmp), 1-METHYLPYRROLIDONE [MI], N-METHYL-2-KETOPYRROLIDINE, HY-Y1275, Tox21_202350, Tox21_300097, 1-Methyl-2-pyrrolidinone, 99.5%, 1-Methyl-2-pyrrolidinone, anhydrous, BDBM50353587, N-Methyl pyrrolidon (Peptide Grade), s6282, STL183295, N-Methyl-2-pyrrolidinone ACS reagent, AKOS000120930, 1-Methyl-2-pyrrolidinone, BioSolv(R), DB12521, 1-Methyl-2-pyrrolidone, Reagent, ACS, 1-METHYL-2-PYRROLIDINONE [HSDB], NCGC00247902-01, NCGC00247902-02, NCGC00253935-01, NCGC00259899-01, BP-31156, DB-230823, DB-231528, 1-Methyl-2-pyrrolidone (Low water content), AM20110252, CS-0017258, M0418, M3055, NS00009178, 1-Methyl-2-pyrrolidinone, analytical standard, 1-Methyl-2-pyrrolidinone, anhydrous, 99.5%, 1-Methyl-2-pyrrolidinone, for HPLC, >=99%, 1-Methyl-2-pyrrolidinone, for synthesis, 99%, D78116, Q33103, Residual Solvent Class 2 - N-Methylpyrrolidone, 1-Methyl-2-pyrrolidinone, ReagentPlus(R), 99%, 1-Methyl-2-pyrrolidinone, Spectrophotometric Grade, 2-PYRROLIDONE,1-METHYL MFC5 H9 N1 O1, A842053, 1-Methyl-2-pyrrolidinone, ACS reagent, >=99.0%, 2,5-Dichloro-4,6-dimethyl pyridine-3-carbonitrile, J-504921, J-803017, 1-Methyl-2-pyrrolidinone, biotech. grade, >=99.7%, 1-Methyl-2-pyrrolidinone, Electronic/Cleanroom Grade, 1-Methyl-2-pyrrolidinone, p.a., ACS reagent, 99%, 1-Methyl-2-pyrrolidone, anhydrous, water 40ppm max., 1-Methyl-2-Pyrrolidinon, 99.5 %, ExtraDry, AcroSeal?, 1-Methyl-2-pyrrolidinone, SAJ first grade, >=98.0%, Z104478382, 1-Methyl-2-pyrrolidinone, spectrophotometric grade, >=99%, 1-Methyl-2-pyrrolidinone, Vetec(TM) reagent grade, 98%, InChI=1/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H, 1-Methyl-2-pyrrolidinone, for metal speciation analysis, >=99.0% (GC), Methylpyrrolidone, United States Pharmacopeia (USP) Reference Standard, N-Methylpyrrolidone, Pharmaceutical Secondary Standard; Certified Reference Material, 26876-92-6, G N-Methyl-2-Pyrrolidone, 1-Methyl-2-Pyrrolidone, 1-Methyl-Pyrrolidine-2-one, N-Methyl-2-Pyrrolidinone, 1-methylazacyclopentan-2-one, N-methyl-gamma-butyrolactam, N-methylpyrrolidinone, N-methyl-2-pyrrolidinone, methylpyrrolidone, N-methylpyrrolidone, N-methyl-alpha-pyrrolidone, 1-methylpyrrolidone, 1-methyl-2-pyrrolidone, NMP, M-pyrol, 1-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, 1-Methyl-5-pyrrolidinone, 1-Methylazacyclopentan-2-one, 1-Methylpyrrolidinone, 1-Methylpyrrolidone, 2-Pyrrolidinone, 1-methyl-, M-Pyrol, Methylpyrrolidone, N-Methyl-2-pyrrolidinone, N-Methyl-2-pyrrolidone, N-Methyl-gamma-butyrolactam, N-Methylpyrrolidinone, N-Methylpyrrolidone, NMP, Norleucine, 5-oxo-, DL, [ChemIDplus] UN1993, 1-Methyl-2-pyrrolidone, N-Methylpyrrolidone, N-Methylpyrrolidinone, NMP, 1-Methyl-2-pyrrolidone, NMP, N-methylpyrrolidinone, N-methyl-2-pyrrolinone, 1-methyl-5-pyrrolidinone, methylpyrrolidone, N-methylpyrrolidone, composite constituent, N-Methyl Pyrrolidone, 872-50-4, 1-Methyl-Pyrrolidone, Methyl Pyrrolidone, Methyl Pyrrolidone, N-Methyl-2-Pyrrolidone, N-Methyl-2-Pyrrolidone, N-Methylpyrrolidinone, N-Methyl-2-Pyrrolidinone, 1-Methyl-Pyrrolidin-2-one, 1-Methylpyrrolidin-2-one, NMP Solvent, NMP



N-methyl 2-pyrrolidone (NMP) is a pale yellow organic compound and is a non-flammable product.
N-methyl 2-pyrrolidone (NMP) is miscible with water and most other solvents, always test a little and see how it mixes.
N-methyl 2-pyrrolidone (NMP) is denser than water at 1.03g/cc with a boiling range of 56 ºC.


N-methyl 2-pyrrolidone (NMP) is a flammable organic liquid consisting of a 5-membered lactam.
Available in various quantities and reagent grades, N-methyl 2-pyrrolidone (NMP) is a dipolar aprotic solvent with petrochemical, plastic, and pharmaceutical applications.


N-methyl 2-pyrrolidone (NMP) is a clear colorless liquid with a fish-like odor.
N-methyl 2-pyrrolidone (NMP) is almost colorless liquid with an amine odor.
N-methyl 2-pyrrolidone (NMP) is a solvent used in a range of products.


The average consumer is most likely to encounter N-methyl 2-pyrrolidone (NMP) in paint strippers, even though safer alternatives exist.
N-methyl 2-pyrrolidone (NMP) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


N-methyl 2-pyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.
N-methyl 2-pyrrolidone (NMP) is produced and imported into the United States, with use estimated at over 184 million pounds per year.


N-methyl 2-pyrrolidone (NMP) is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).
Organic and inorganic substances are highly soluble in N-methyl 2-pyrrolidone (NMP).


N-methyl 2-pyrrolidone (NMP) mixes with water in all proportions.
N-methyl 2-pyrrolidone (NMP) has a high flash point compared to similar solvents.
The boiling point of N-methyl 2-pyrrolidone (NMP) is high, the freezing point is low, and handling is easy.


N-methyl 2-pyrrolidone (NMP) is chemically and thermally stable, and not corrosive.
N-methyl 2-pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid.
N-methyl 2-pyrrolidone (NMP) has been closely linked to developmental impacts including miscarriages.


N-methyl 2-pyrrolidone (NMP) has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.
Additionally, the polar nature and the low surface tension of N-methyl 2-pyrrolidone (NMP) makes it an excellent cleaning medium and paint stripping solvent.


N-methyl 2-pyrrolidone (NMP) is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in.
N-methyl 2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
N-methyl 2-pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.


N-methyl 2-pyrrolidone (NMP) is miscible with water and with most common organic solvents.
N-methyl 2-pyrrolidone (NMP) is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).


N-methyl 2-pyrrolidone (NMP) appears as a clear colorless liquid with a "fishlike" odor.
N-methyl 2-pyrrolidone (NMP) is denser than water.
Flash point of N-methyl 2-pyrrolidone (NMP) is 199 °F.


N-methyl 2-pyrrolidone (NMP) is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.
N-methyl 2-pyrrolidone (NMP) has a role as a polar aprotic solvent.


N-methyl 2-pyrrolidone (NMP) is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones.
N-methyl 2-pyrrolidone (NMP) is under investigation for the treatment of Multiple Myeloma.
N-methyl 2-pyrrolidone (NMP) is a natural product found in Microtropis japonica, Melicope hayesii, and other organisms with data available.


N-methyl 2-pyrrolidone (NMP) is a chemical compound with 5-membered lactam structure.
N-methyl 2-pyrrolidone (NMP) is a colorless to slightly yellow liquid miscible with water.
N-methyl 2-pyrrolidone (NMP) has been identified as a reproductive toxicant, first by California in 2001 and then by the European Commission in 2003.


In the face of increasing regulation, some manufacturers are considering alternative solvents for some applications, especially where worker exposure is difficult to control, such as in paint stripping, graffiti removal, and agriculture.
N-methyl 2-pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.



USES and APPLICATIONS of N-METHYL 2-PYRROLIDONE (NMP):
N-methyl 2-pyrrolidone (NMP) is a solvent used in a variety of industries and applications such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning, and industrial/ domestic cleaning.
Due to its good solvency properties, N-methyl 2-pyrrolidone (NMP) is used to dissolve a wide range of polymers.


N-methyl 2-pyrrolidone (NMP) is used in the surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-methyl 2-pyrrolidone (NMP) is a used solvent for polymers, textile coatings, resins, agricultural chemicals, paint removal, degreasing; petrochemical processing; pharmaceuticals.


N-methyl 2-pyrrolidone (NMP) is used as a solvent for chemicals and resins in the microelectronics and pharmaceutical industries.
N-methyl 2-pyrrolidone (NMP) is widely used to replace other solvents, e.g., for paint stripping and lube oil extraction.
N-methyl 2-pyrrolidone (NMP) is used as a solvent for pesticides, coatings, adhesives, dyes, pigments, polymers, and polyurethane foam cleanup.


N-methyl 2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
N-methyl 2-pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.
N-methyl 2-pyrrolidone (NMP) is miscible with water and with most common organic solvents.


N-methyl 2-pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-methyl 2-pyrrolidone (NMP) is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials


N-methyl 2-pyrrolidone (NMP) is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Other release to the environment of N-methyl 2-pyrrolidone (NMP) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).


N-methyl 2-pyrrolidone (NMP) can be found in complex articles, with no release intended: vehicles and vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).
N-methyl 2-pyrrolidone (NMP) is used in the following areas: formulation of mixtures and/or re-packaging.


N-methyl 2-pyrrolidone (NMP) is used in the following products: pH regulators and water treatment products and laboratory chemicals. N-methyl 2-pyrrolidone (NMP) is used in the following areas: scientific research and development, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.


Other release to the environment of N-methyl 2-pyrrolidone (NMP) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


N-methyl 2-pyrrolidone (NMP) is used in the following products: metal surface treatment products, non-metal-surface treatment products, polymers and coating products.
Release to the environment of N-methyl 2-pyrrolidone (NMP) can occur from industrial use: formulation of mixtures and manufacturing of the substance.


N-methyl 2-pyrrolidone (NMP) is used in the following products: semiconductors, washing & cleaning products, metal surface treatment products and non-metal-surface treatment products.
N-methyl 2-pyrrolidone (NMP) is used in the following areas: formulation of mixtures and/or re-packaging.


N-methyl 2-pyrrolidone (NMP) is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of N-methyl 2-pyrrolidone (NMP) can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.


Release to the environment of N-methyl 2-pyrrolidone (NMP) can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
N-methyl 2-pyrrolidone (NMP) is used for the manufacture of: chemicals.


N-methyl 2-pyrrolidone (NMP) is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-methyl 2-pyrrolidone (NMP) is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.


Its good solvency properties have led to N-methyl 2-pyrrolidone (NMP)'s use to dissolve a wide range of polymers.
Specifically, N-methyl 2-pyrrolidone (NMP) is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-methyl 2-pyrrolidone (NMP) is also used as a solvent in the commercial preparation of polyphenylene sulfide.


In the pharmaceutical industry, N-methyl 2-pyrrolidone (NMP) is used in the formulation for drugs by both oral and transdermal delivery routes.
It is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because N-methyl 2-pyrrolidone (NMP) has a unique ability to dissolve polyvinylidene fluoride binder.


N-methyl 2-pyrrolidone (NMP) is used in petrochemical processing, and as a solvent for surface treatment of textiles, resins and metal coated plastics or as a paint stripper.
In the pharmaceutical industry, N-methyl 2-pyrrolidone (NMP) is used in the formulation for drugs by both oral and transdermal delivery routes.


-Agrochemicals:
N-methyl 2-pyrrolidone (NMP) can be used as solvent during synthesis or as a formulation agent.
N-methyl 2-pyrrolidone (NMP) is polar aprotic solvent with the properties of low toxicity, high boiling point, powerful solvency, good selectivity and stability.

N-methyl 2-pyrrolidone (NMP) is widely applied to aromatic hydrocarbons extracting, acetylene and diolefine purification.
N-methyl 2-pyrrolidone (NMP) can be used as polymer solvents and polymerization process medium, etc., which are called engineering plastics.
Besides, N-methyl 2-pyrrolidone (NMP) can also be used as aromatic fibre, insulate pesticide, pigment and detergent, etc.

N-methyl 2-pyrrolidone (NMP) is used Electronics, Paints & coatings,
Polymer & plastic, Process solvents, Solvents/stripping agents, and Wire wrappers.
N-methyl 2-pyrrolidone (NMP) is used as a solvent for engineering polymers and coating resins.


-Electronics:
N-methyl 2-pyrrolidone (NMP) is used as photoresist stripper, for defluxing, degreasing and cleaning.
N-methyl 2-pyrrolidone (NMP) is a solvent for the production of FCCL, polyamide/polyimide wire enamels, epoxy and polyurethane coatings, ...


-Pharmaceuticals:
NMP can be used as solvent, extraction medium, …
Industrial and household cleaning:
NMP is used for paint stripping, in graffiti removers, oven cleaners, in automotive and industrial cleaner formulations, ...


-Petrochemical processing:
N-methyl 2-pyrrolidone (NMP) is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction, lube oil purification, ...
As illustration for the strong selectivity of N-methyl 2-pyrrolidone (NMP) towards acetylene, the table below shows the solubility of acetylene in various solvents.



CHARACTERISTICS OF N-METHYL 2-PYRROLIDONE (NMP):
N-methyl 2-pyrrolidone (NMP) is a 5-member-ring compound containing nitrogen.
N-methyl 2-pyrrolidone (NMP) has a wide range of uses due to the following excellent characteristics.



PREPARATION OF N-METHYL 2-PYRROLIDONE (NMP):
N-methyl 2-pyrrolidone (NMP) is produced industrially by a typical ester-to-amide conversion, by treating gamma-butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 200,000 to 250,000 tons are produced annually.



PHYSICAL and CHEMICAL PROPERTIES of N-METHYL 2-PYRROLIDONE (NMP):
Molecular Weight: 99.14 g/mol
Appearance: Clear colorless liquid
Odor: Faint amine smell
Specific Gravity (25/4°C): 1.027
Viscosity (mPa･s): 1.89 (25°C)
Boiling Point (°C): 202
Freezing Point (°C): -23
Vapor specific gravity: 3.4
Flash Point (°C): 99 (open cup)
Autoignition Temperature (°C): 252
CAS number: 872-50-4
EC index number: 606-021-00-7

EC number: 212-828-1
Hill Formula: C₅H₉NO
Molar Mass: 99.13 g/mol
HS Code: 2933 79 90
Boiling point: 202 °C (1013 hPa)
Density: 1.03 g/cm³ (25 °C)
Explosion limit: 1.3 - 9.5% (V)
Flash point: 91 °C
Ignition temperature: 245 °C
Melting Point: -24.2 °C
pH value: 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure: 0.32 hPa (20 °C)
Solubility: 1000 g/l

Physical description: A clear colorless liquid with a fish-like odor.
Boiling point: 396°F
Molecular weight: 99.13
Freezing point/melting point: -9°F
Vapor pressure
Flash point: 204°F
Vapor density: 3.4
Specific gravity: 1.03
Ionization potential
Lower explosive limit (LEL)
Upper explosive limit (UEL)
NFPA health rating: 2
NFPA fire rating: 2
NFPA reactivity rating: 0

Appearance (Clarity): Clear
Assay (GC): min. 99.9%
Residual solvents
GC-HS Class 1: max. 1ppm
GC-HS Class 2: max. 10ppm
GC-HS Class 3: max. 50ppm
Density (g/ml) @ 20°C: 1.029-1.031
Refractive Index (20°C): 1.470-1.471
Boiling Range: 201-202°C
Non Volatile Matter: max. 0.0005%
Water (KF): max. 0.05%
Appearance (Colour): Colorless
Appearance (Form): Liquid

Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.031
Refractive Index (20°C): 1.470-1.471
Boiling Range: 201-202°C
Non Volatile Matter: max. 0.001%
Water (KF): max. 0.1%
Chemical formula: C5H9NO
Molar mass: 99.133 g·mol−1
Density: 1.028 g/cm3
Melting point: −24 °C (−11 °F; 249 K)
Boiling point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water: Soluble

Solubility in Ethanol, acetone, diethylether,
ethyl acetate, chloroform, benzene: Soluble
log P: −0.40
Molecular Weight: 99.14
Appearance: Clear colorless liquid
Odor: Faint amine smell
Specific Gravity (25/4℃): 1.027
Viscosity(mPa･s) : 1.89（25℃）
Boiling Point (℃): 202
Freezing Point (℃): -23
Vapor specific gravity: 3.4
Flash Point (℃): 99 (open cup)
Autoignition Temperature (℃): 252

Physical state: clear, liquid
Color: colorless
Odor: amine-like
Melting point/freezing point:
Melting point/range: -24 °C
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 9,5 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 91 °C
Autoignition temperature :245 °C at 1.013 hPa - DIN 51794
Decomposition temperature: No data available
pH: 8,5 - 10,0 at 100 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 1,661 mPa.s at 25 °C

Water solubility: 1.000 g/l at 20 °C - soluble
Partition coefficient: n-octanol/water:
log Pow: -0,46 at 25 °C
Bioaccumulation is not expected.
Vapor pressure: 0,32 hPa at 20 °C
Density: 1,028 g/mL at 25 °C
Relative densit:y No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:

Conductivity: 0,2 - 0,4 µS/cm
Surface tension: 40,4 mN/m
Relative vapor density: 3,42 - (Air = 1.0)
Boiling point: 396°F
Molecular weight: 99.13
Freezing point/melting point: -9°F
Flash point: 204°F
Vapor density: 3.4
Specific gravity: 1.03
NFPA health rating: 2
NFPA fire rating: 2
NFPA reactivity rating: 0
Appearance (Clarity): Clear
Appearance (Colour): Colourless

Appearance (Form): Liquid
Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.033
Refractive Index (20°C): 1.470-1.472
Boiling Range: 202-204°C
Water (KF): max. 0.1%
Molecular Weight： 99.13110
Exact Mass： 99.13
EC Number： 212-828-1
UNII： JR9CE63FPM
ICSC Number： 0513
NSC Number： 4594
UN Number： 1993

DSSTox ID： DTXSID6020856
Color/Form： Clear liquid
HScode: 2933990090
PSA: 20.31000
XLogP3： 0.17650
Density： 1.027 g/cm3 @ Temp: 25 °C
Melting Point： -25 °C
Boiling Point： 202 °C @ Press: 760 Torr
Flash Point： 91ºC
Refractive Index： n20/D 1.479
Water Solubility： H2O: >=10 g/100 mL at 20 ºC
Storage Conditions： 2-8ºC
Vapor Pressure： 0.29 mm Hg ( 20 °C)

Vapor Density： 3.4 (vs air)
Explosive limit： vol% in air: 1.3.5
Odor： Mild amine odor
PH： pH = 7.7-8
Henrys Law Constant： 3.20e-09 atm-m3/mole
Experimental Properties：
Dipole moment at 25 °C: 4.09 debye
Dielectric constant at 25 °C: 32.3
Hydroxy radical rate constant = 7.4X10-11 cu cm/molecule-sec at 25 °C
Air and Water Reactions： Soluble in water.
Reactive Group： Amides and Imides
Autoignition Temperature： 655 °F (346 °C)|245 °C
Heat of Combustion： 719 kcal/mol
Heat of Vaporization： 127.3 kcal/Kg

Critical Temperature & Pressure：
Critical temperature = 451 °C
Critical pressure = 4.78 MPa
Empirical formula: C5H9NO
Molar mass (M): 99,13 g/mol
Density (D): 1,03 g/cm³
Boiling point (bp): 204,3 °C
Flash point (flp): 91 °C
Melting point (mp): -24,2 °C
CAS Number: 872-50-4
Molecular Weight: 99.13 g/mol
Appearance: Colorless liquid
Melting Point: -24 C

Boiling Point: 202 C
Density: 1.028 g/mL at 25 C
Melting point: -24 °C (lit.)
Boiling point: 202 °C (lit.) 81-82 °C/10 mmHg (lit.)
Density: 1.028 g/mL at 25 °C (lit.)
vapor density: 3.4 (vs air)
vapor pressure: 0.29 mm Hg ( 20 °C)
refractive index: n20/D 1.479
Flash point: 187 °F
storage temp.: Store at +5°C to +30°C.
solubility: ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
form: Liquid
pka: -0.41±0.20(Predicted)

color: ≤20(APHA)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
Odor: Slight amine odor
PH Range: 7.7 - 8.0
explosive limit: 1.3-9.5%(V)
Water Solubility: >=10 g/100 mL at 20 ºC
Sensitive: Hygroscopic
λmax: 283nm(MeOH)(lit.)
Merck: 14,6117
BRN: 106420
Stability: Stable, but decomposes upon exposure to light.
InChIKey: SECXISVLQFMRJM-UHFFFAOYSA-N
LogP: -0.46 at 25℃
Chemical Formula: C5H9NO
Molar Mass: 99.133 g·mol−1
Density: 1.028 g/cm³

Melting Point: −24 °C (−11 °F; 249 K)
Boiling Point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in Water: Soluble
Solubility in Ethanol, Acetone, Diethyl Ether,
Ethyl Acetate, Chloroform, Benzene: Soluble
log P: −0.40
Molecular Weight: 99.13 g/mol
XLogP3: -0.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0

Exact Mass: 99.068413911 g/mol
Monoisotopic Mass: 99.068413911 g/mol
Topological Polar Surface Area: 20.3 Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 90.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of N-METHYL 2-PYRROLIDONE (NMP):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of N-METHYL 2-PYRROLIDONE (NMP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of N-METHYL 2-PYRROLIDONE (NMP):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-METHYL 2-PYRROLIDONE (NMP):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: 60 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A-(P2)
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of N-METHYL 2-PYRROLIDONE (NMP):
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
Take precautionary measures against static discharge.
*Hygiene measures:
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.
Moisture sensitive.



STABILITY and REACTIVITY of N-METHYL 2-PYRROLIDONE (NMP):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

1-Methyl-2-pyrrolidinone; 1-Methyl-5-Pyrrolidinone; Methylpyrrolidone; N-Methylpyrrolidone; N-Methyl-2-Pyrrolidone; NMP; 1-Methyl-2-pyrrolidone; m-pyrrole; 1-Methylpyrrolidinone; N-methylpyrrolidinone; N-Methyl-2-pyrrolidinone; cas no:872-50-4

N-methyl pyrrolidinone (NMP) is a highly versatile organic solvent with the chemical formula C5H9NO.
N-methyl pyrrolidinone is a colorless to pale yellow liquid that is soluble in water and most organic solvents.
N-methyl pyrrolidinone is widely used in various industrial applications due to its unique properties, including high boiling point, low vapor pressure, good solvency, and excellent chemical stability.

CAS Number: 872-50-4
EC Number: 212-828-1



APPLICATIONS


N-methyl pyrrolidinone (NMP) has a wide range of industrial applications, including:

Solvent for the production of electronics, such as semiconductors, displays, and printed circuit boards (PCBs)
Solvent for the production of lithium-ion batteries for electric vehicles and electronic devices
Solvent for the manufacture of pharmaceuticals, such as antibiotics, antifungal agents, and analgesics
Solvent for the production of polymers, such as polyvinylpyrrolidone (PVP), nylon, and aramid fibers
Solvent for the production of synthetic fibers, such as carbon fibers and aramid fibers
Solvent for the production of agrochemicals, such as herbicides and insecticides
Solvent for the extraction of petrochemicals and natural gas
Solvent for the formulation of personal care products, such as lotions and shampoos
Solvent for the production of resins, such as epoxy resins, and adhesives
Solvent for the printing industry, where it is used to clean printing plates and equipment
Solvent for the production of coatings, paints, and varnishes
Solvent for the production of nanomaterials, such as graphene
Solvent for the extraction of metals from ores and other raw materials.


N-methyl pyrrolidinone's excellent solvency, high boiling point, low vapor pressure, and stability make it a popular choice in these and other industrial applications.
N-methyl pyrrolidinone is commonly used as a solvent in the production of semiconductors and other electronics.

Lithium-ion batteries, which power many electronic devices and electric vehicles, are produced using N-methyl pyrrolidinone as a solvent.
In the pharmaceutical industry, N-methyl pyrrolidinone is used as a solvent in the production of various drugs, including antibiotics and antifungal agents.

N-methyl pyrrolidinone is a key component in the production of polyvinylpyrrolidone (PVP), which is used in a variety of applications, including as a binder in tablets and capsules.
The excellent solvency of N-methyl pyrrolidinone makes it useful in the production of synthetic fibers, such as carbon fibers and aramid fibers.

The agrochemical industry uses N-methyl pyrrolidinone as a solvent for herbicides and insecticides.
In the oil and gas industry, N-methyl pyrrolidinone is used as a solvent for the extraction of petrochemicals and natural gas.

N-methyl pyrrolidinone is a popular solvent in the formulation of personal care products, such as lotions and shampoos.
The production of epoxy resins and adhesives often involves the use of N-methyl pyrrolidinone as a solvent.
The printing industry uses N-methyl pyrrolidinone as a solvent to clean printing plates and equipment.

The high boiling point and low vapor pressure of N-methyl pyrrolidinone make it useful in the production of coatings, paints, and varnishes.
N-methyl pyrrolidinone is used in the production of nanomaterials, such as graphene, due to its excellent solvency and stability.

N-methyl pyrrolidinone is also used in the extraction of metals from ores and other raw materials.
In the production of carbon nanotubes, N-methyl pyrrolidinone is used as a solvent to dissolve the starting material.

The textile industry uses N-methyl pyrrolidinone as a solvent to produce synthetic fibers and fabrics.
N-methyl pyrrolidinone is used in the production of paints and coatings for the automotive industry.
The electronics industry uses N-methyl pyrrolidinone as a solvent for the production of organic light-emitting diodes (OLEDs).

The production of polyurethane foams often involves the use of N-methyl pyrrolidinone as a solvent.
The food industry uses N-methyl pyrrolidinone as a solvent in the production of flavorings and fragrances.

In the production of resins and adhesives, N-methyl pyrrolidinone is used as a solvent and a reaction medium.
N-methyl pyrrolidinone is used in the production of high-performance fibers, such as Kevlar, due to its ability to dissolve a wide range of polymers.

The automotive industry uses N-methyl pyrrolidinone as a solvent for the production of car parts and components.
N-methyl pyrrolidinone is used in the production of inkjet inks, which are used in printers and other electronic devices.

N-methyl pyrrolidinone is used as a solvent in the production of synthetic fibers and resins.
N-methyl pyrrolidinone is a common solvent for polymeric materials, such as polyvinyl chloride (PVC) and polyurethanes.
In the pharmaceutical industry, N-methyl pyrrolidinone is used as a reaction solvent and extraction agent.

N-methyl pyrrolidinone is used in the synthesis of numerous pharmaceuticals, such as analgesics, antibiotics, and antivirals.
N-methyl pyrrolidinone is a solvent for electrolyte solutions in lithium-ion batteries.

N-methyl pyrrolidinone is used as a solvent and wetting agent in the manufacture of photoresist materials for semiconductor manufacturing.
N-methyl pyrrolidinone is used as a solvent in the production of adhesives and sealants.

N-methyl pyrrolidinone is a solvent for dyes and pigments in the textile industry.
N-methyl pyrrolidinone is used as a reaction solvent in the synthesis of advanced materials, such as carbon nanotubes and graphene.

N-methyl pyrrolidinone is a solvent for polymers used in the production of plastic films, coatings, and laminates.
N-methyl pyrrolidinone is used as a solvent in the production of agricultural chemicals, such as herbicides and fungicides.

N-methyl pyrrolidinone is used as a cleaning agent in the electronics industry, especially for the removal of photoresist materials.
N-methyl pyrrolidinone is used as a solvent for inkjet printing inks and toners.
N-methyl pyrrolidinone is a solvent for metal-organic frameworks (MOFs), which have potential applications in gas storage and separation.

N-methyl pyrrolidinone is used as a solvent for gas scrubbing in carbon capture and storage (CCS) systems.
N-methyl pyrrolidinone is used as a solvent for the extraction of aromatic hydrocarbons from petroleum.

N-methyl pyrrolidinone is used as a reaction solvent in the synthesis of fuel additives, such as detergents and dispersants.
N-methyl pyrrolidinone is a solvent for resins used in the production of composite materials, such as fiberglass.

N-methyl pyrrolidinone is used as a solvent for the production of industrial coatings, such as automotive paints.
N-methyl pyrrolidinone is used as a solvent for the production of polyether polyols, which are used in the production of polyurethane foams and elastomers.

N-methyl pyrrolidinone is used as a solvent in the production of printing inks for packaging materials.
N-methyl pyrrolidinone is used as a solvent for the production of flavors and fragrances in the food and cosmetics industries.
N-methyl pyrrolidinone is used as a reaction solvent in the synthesis of surfactants, which are used in detergents and personal care products.

N-methyl pyrrolidinone is a solvent for resins used in the production of flooring materials, such as vinyl and linoleum.
N-methyl pyrrolidinone is used as a solvent for the production of polyamide fibers, such as nylon.

N-methyl pyrrolidinone is used in the production of various chemicals, including pharmaceuticals, agrochemicals, and polymers.
N-methyl pyrrolidinone is a common solvent in the production of polyvinylidene fluoride and other polymers.

N-methyl pyrrolidinone is used in the purification of natural gas and refinery gas streams.
N-methyl pyrrolidinone is used as a co-solvent in printing ink formulations.

N-methyl pyrrolidinone is commonly used in the production of lithium-ion batteries.
N-methyl pyrrolidinone is used in the purification of certain types of biogas.
N-methyl pyrrolidinone is used as a solvent in the production of pesticides and herbicides.

N-methyl pyrrolidinone is commonly used in the production of electronics and semiconductors.
N-methyl pyrrolidinone is used in the production of coatings and adhesives.

N-methyl pyrrolidinone is used as a solvent in the production of dyes and pigments.
N-methyl pyrrolidinone is used in the production of cleaning and degreasing products.

N-methyl pyrrolidinone is used in the production of acrylic fibers and films.
N-methyl pyrrolidinone is used as a solvent in the production of flavors and fragrances.

N-methyl pyrrolidinone is used in the production of magnetic tape.
N-methyl pyrrolidinone is used in the production of photographic film and paper.

N-methyl pyrrolidinone is used in the production of surfactants.
N-methyl pyrrolidinone is used in the production of resins and plasticizers.
N-methyl pyrrolidinone is used in the production of synthetic fibers, such as nylon.

N-methyl pyrrolidinone is used in the production of rubber products.
N-methyl pyrrolidinone is used as a solvent in the production of food additives and preservatives.

N-methyl pyrrolidinone is used in the production of pharmaceutical intermediates.
N-methyl pyrrolidinone is used in the production of veterinary medicines.

N-methyl pyrrolidinone is used in the production of flavors and fragrances for the cosmetic industry.
N-methyl pyrrolidinone is used in the production of automotive parts.
N-methyl pyrrolidinone is used in the production of printing plates for the graphic arts industry.



DESCRIPTION


N-methyl pyrrolidinone (NMP) is a highly versatile organic solvent with the chemical formula C5H9NO.
N-methyl pyrrolidinone is a colorless to pale yellow liquid that is soluble in water and most organic solvents.
N-methyl pyrrolidinone is widely used in various industrial applications due to its unique properties, including high boiling point, low vapor pressure, good solvency, and excellent chemical stability.

N-methyl pyrrolidinone is commonly used in the production of electronics, pharmaceuticals, and polymers, as well as in the extraction of petrochemicals and natural gas.
N-methyl pyrrolidinone is also used as a solvent in the manufacturing of coatings, paints, and adhesives.
N-methyl pyrrolidinone has a relatively low toxicity and is considered safe for most industrial uses, although prolonged or repeated exposure may cause irritation to the skin, eyes, and respiratory tract.

N-methyl pyrrolidinone is a highly versatile organic solvent with a wide range of industrial applications.
N-methyl pyrrolidinone is a colorless to pale yellow liquid that is soluble in water and most organic solvents.

N-methyl pyrrolidinone has a high boiling point and low vapor pressure, making it useful in high-temperature applications.
N-methyl pyrrolidinone has excellent solvency properties, allowing it to dissolve a wide range of organic and inorganic substances.
N-methyl pyrrolidinone is widely used in the production of electronics, pharmaceuticals, and polymers.

N-methyl pyrrolidinone is a popular solvent for the extraction of petrochemicals and natural gas.
N-methyl pyrrolidinone is used in the manufacturing of coatings, paints, and adhesives.

N-methyl pyrrolidinone has a low toxicity and is considered safe for most industrial uses.
N-methyl pyrrolidinone is highly stable and does not react with many other chemicals.

N-methyl pyrrolidinone is a polar solvent that can dissolve both polar and nonpolar substances.
N-methyl pyrrolidinone has a relatively slow evaporation rate, making it useful in applications requiring long exposure times.

N-methyl pyrrolidinone has a slightly sweet odor and a mild taste.
N-methyl pyrrolidinone is not flammable and does not pose a significant fire hazard.
N-methyl pyrrolidinone is used in the production of lithium-ion batteries, which power many electronic devices.

N-methyl pyrrolidinone is used as a solvent in the manufacture of pharmaceuticals such as antibiotics and antifungal agents.
N-methyl pyrrolidinone is a key component in the production of polyvinylpyrrolidone (PVP), a common polymer used in a wide range of applications.

N-methyl pyrrolidinone is used in the production of synthetic fibers such as aramid and carbon fibers.
N-methyl pyrrolidinone is used as a solvent in the manufacture of printed circuit boards (PCBs).

N-methyl pyrrolidinone is used as a solvent in the production of graphene and other nanomaterials.
N-methyl pyrrolidinone is used in the manufacture of resins, such as epoxy resins, which are widely used in the construction industry.
N-methyl pyrrolidinone is used as a solvent in the extraction of metals from ores and other raw materials.

N-methyl pyrrolidinone is used in the production of agrochemicals, such as herbicides and insecticides.
N-methyl pyrrolidinone is used in the production of rubber and plastics.

N-methyl pyrrolidinone is used in the formulation of personal care products such as shampoos and lotions.
N-methyl pyrrolidinone is used as a solvent in the printing industry, where it is used to clean printing plates and equipment.



PROPERTIES


Physical properties:

Molecular formula: C5H9NO
Molecular weight: 99.13 g/mol
Appearance: clear, colorless to pale yellow liquid
Odor: amine-like
Melting point: -24 °C (-11 °F)
Boiling point: 202 °C (396 °F)
Density: 1.028 g/mL at 25 °C (77 °F)
Vapor pressure: 0.11 kPa (25 °C)
Solubility: miscible in water, ethanol, acetone, benzene, and other organic solvents
Flash point: 95 °C (203 °F)


Chemical properties:

N-methyl pyrrolidinone is a polar aprotic solvent.
N-methyl pyrrolidinone is hygroscopic and can absorb water from the atmosphere.
N-methyl pyrrolidinone can undergo hydrogen bonding with other polar compounds.

N-methyl pyrrolidinone can react with oxidizing agents to form potentially explosive compounds.
N-methyl pyrrolidinone can react with acids to form salts.
N-methyl pyrrolidinone can be hydrolyzed under acidic or basic conditions.

N-methyl pyrrolidinone can participate in various types of chemical reactions, including substitution, addition, and elimination reactions.
N-methyl pyrrolidinone is stable under normal storage conditions.


Toxicological properties:

N-methyl pyrrolidinone is classified as a reproductive toxin and a skin sensitizer.
N-methyl pyrrolidinone can cause skin and eye irritation upon contact.
Inhalation of N-methyl pyrrolidinone can cause respiratory irritation.

Prolonged or repeated exposure can cause damage to the liver and kidneys.
N-methyl pyrrolidinone is not classified as a carcinogen by the International Agency for Research on Cancer (IARC) or the US National Toxicology Program (NTP).
N-methyl pyrrolidinone has a low potential to bioaccumulate in aquatic organisms.


Environmental properties:

N-methyl pyrrolidinone is moderately persistent in the environment.
N-methyl pyrrolidinone can be degraded by microorganisms and by some chemical processes.
N-methyl pyrrolidinone has low to moderate mobility in soil, depending on the soil type.

N-methyl pyrrolidinone has a low potential to leach into groundwater.
N-methyl pyrrolidinone is not expected to accumulate in sediment or bioconcentrate in aquatic organisms.
N-methyl pyrrolidinone is not classified as an ozone-depleting substance or a greenhouse gas.



FIRST AID


Here are some first aid measures that should be taken in case of exposure to N-methyl pyrrolidinone:


Inhalation:

Move the affected person to an area with fresh air.
If the person is not breathing, perform artificial respiration.
Seek medical attention immediately.


Skin contact:

Remove contaminated clothing and rinse the affected area with plenty of water.
If the chemical has been absorbed through the skin or if skin irritation occurs, seek medical attention.


Eye contact:

Rinse eyes with water for several minutes, lifting upper and lower eyelids occasionally.
Seek medical attention if eye irritation persists.


Ingestion:

Do not induce vomiting unless directed to do so by a medical professional.
Rinse the mouth with water and seek medical attention immediately.
Note: Never give anything by mouth to an unconscious person.


Other measures:

If large amounts of N-methyl pyrrolidinone are spilled or released, evacuate the area and notify the appropriate authorities.
Wear appropriate protective equipment, such as gloves and eye protection, when handling the chemical.
Store and handle the chemical in a well-ventilated area away from sources of heat or ignition.



HANDLING AND STORAGE


Handling:

Use the chemical in a well-ventilated area.
Wear appropriate protective equipment, such as gloves and eye protection, when handling the chemical.

Avoid contact with skin, eyes, and clothing.
Do not eat, drink, or smoke while handling the chemical.


Storage:

Store N-methyl pyrrolidinone in a cool, dry, well-ventilated area away from sources of heat or ignition.
Keep containers tightly closed and upright to prevent leaks or spills.
Store the chemical away from incompatible materials, such as strong oxidizing agents.

Store the chemical in a secure area to prevent unauthorized access.
Follow all local and national regulations for the storage of hazardous materials.


Note: Always refer to the specific safety data sheet (SDS) for N-methyl pyrrolidinone for detailed handling and storage instructions.



SYNONYMS


1-Methyl-2-pyrrolidinone
NMP
N-methyl-2-pyrrolidinone
1-methyl-5-azacyclooctan-2-one
N-methylpyrrolidone
N-methyltetrahydro-2H-pyrrole-2-one
1-Methyl-5-pyrrolidin-2-one
Pyrrolidin-2-one, 1-methyl-
1-Methyl-2-pyrrolidone
NSC 88585
UNII-95TI6B3ANO
AC1L1QZM
AI3-52427
AKOS006269523
BRN 1104832
CCRIS 7320
CHEBI:8195
CHEMBL39423
DTXSID0026601
EINECS 203-296-1
LS-102790
MFCD00003168
NSC88585
SBB056620
STL239285
1-Methyl-5-pyrrolidone-2
2-Pyrrolidinone, 1-methyl-
5-Methyl-2-pyrrolidone
Alpha-n-methylpyrrolidone
Dipolar aprotic solvent
N-Methyl-2-pyrrolidon
N-Methyl-2-pyrrolidonum
N-Methyl-γ-pyrrolidone
N-Methyl-γ-pyrrolidon
N-Methyl-γ-valerolactam
N-Methyl-5-azacyclooctan-2-one
N-Methylpyrrolidonum
N-Methyltetrahydro-2-pyrrole-2-one
NMPR
Pyrrolidone, 1-methyl-2-
1-Methyl-5-oxo-pyrrolidine-2
2-Pyrrolidone, N-methyl-
5-Pyrrolidone-2, 1-methyl
5-Pyrrolidone-2, N-methyl-
AKOS015904012
AKOS027099352
ANW-42391
AS-12391
BC206080
C11045
FEMA No. 3725
Hexahydro-1-methyl-5H-1,3-diazin-5-one
M-Pyrol
M-Pyrol®
Methylpyrrolidinone
MPD
N-Methyl-2-pyrrolidone
N-Methylbutyrolactam
N-Methylvalerolactam
N-Methylpyrrolidine-2-one
N-MP
N-OMP
N-Methylbutyramide
N-Methyl-γ-butyrolactam
N-Methyl-γ-valerolactone
NSC 656593
Pyrrolidin-2-one, 1-methyl-
Pyrrolidone, 1-methyl-
Pyrrolidone, N-methyl-
UNII-95F2C2G85B
1-Methyl-5-pyrrolidone-2-carboxamide
2-Pyrrolidone, 1-methyl-, (S)-
5-Methyl-2-pyrrolidinone
AK104126

N-Methyl Pyrrolidinone is a natural product found in Microtropis japonica, Melicope hayesii, and other organisms with data available.
N-Methyl Pyrrolidinone appears as a clear colorless liquid
N-Methyl Pyrrolidinone has a "fishlike" odor


CAS NUMBER: 872-50-4

EC NUMBER: 212-828-1

MOLECULAR FORMULA: C5H9NO

MOLECULAR WEIGHT: 99.13

IUPAC NAME: 1-methylpyrrolidin-2-one


N-Methyl Pyrrolidinone is denser than water.
N-Methyl Pyrrolidinone's flash point is 199 °F.

N-Methyl Pyrrolidinone is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.
N-Methyl Pyrrolidinone has a role as a polar aprotic solvent.

N-Methyl Pyrrolidinone is used in the following products:
-pH regulators
-water treatment products
-laboratory chemicals

N-Methyl Pyrrolidinone is used in the following areas:
-scientific research and development
-agriculture
-forestry
-fishing and formulation of mixtures and/or re-packaging

N-Methyl Pyrrolidinone is used for the manufacture of: chemicals.
N-Methyl Pyrrolidinone is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones.

USAGE:
-liquids/detergents
-automotive care products
-paints
-coating or adhesives
-fragrances and air fresheners
-outdoor use
-indoor use in close systems
-cooling liquids in refrigerators
-oil-based electric heaters
-outdoor use in close systems
-hydraulic liquids in automotive suspension
-lubricants in motor oil and break fluids


N-Methyl Pyrrolidinone is a substance used as a pH regulator.
N-Methyl Pyrrolidinone is included in the content of water treatment products.

N-Methyl Pyrrolidinone is a compound used in the synthesis of some laboratory chemicals.
N-Methyl Pyrrolidinone aids scientific research and development

N-Methyl Pyrrolidinone is used in agriculture, forestry and fisheries applications
N-Methyl Pyrrolidinone can be used in some chemical processes

N-Methyl Pyrrolidinone is used for indoor use
N-Methyl Pyrrolidinone is found in paints and coatings

N-Methyl Pyrrolidinone is found in adhesives.
N-Methyl Pyrrolidinone is widely used in the automotive industry

N-Methyl Pyrrolidinone can be found in metal surface treatment products
N-Methyl Pyrrolidinone is used in the manufacture of polymers and coating products.

N-Methyl Pyrrolidinone is used in:
-semiconductors
-washing and cleaning products
-metal surface treatment products
-non-metal surface treatment products
-formulation of mixtures
-manufacture of electrical, electronic and optical equipment


N-methyl pyrrolidinone (NMP) is a powerful, aprotic solvent with high solvency and low volatility.
N-Methyl Pyrrolidinone is colorless

N-Methyl Pyrrolidinone has high boiling point and point
N-Methyl Pyrrolidinone has low vapor pressure

N-Methyl Pyrrolidinone has a mild amine-like odor.
N-Methyl Pyrrolidinone has high chemical and thermal stability and is completely miscible with water at all temperatures.

N-Methyl Pyrrolidinone is a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons.
N-Methyl Pyrrolidinone is both recyclable by distillation and readily biodegradable


PHYSICAL PROPERTIES:

-Molecular Weight: 99.13

-XLogP3: -0.5

-Exact Mass: 99.068413911

-Monoisotopic Mass: 99.068413911

-Topological Polar Surface Area: 20.3 Ų

-Physical Description: clear colorless liquid with a fish-like odor

-Color: Colorless

-Form: Liquid

-Odor: Mild amine odor

-Boiling Point: 202 °C

-Melting Point: -25 °C

-Flash Point: 96 °C

-Solubility: Miscible with water

-Density: 1.03

-Vapor Density: 3.4

-Vapor Pressure: 0.34 mmHg

-Autoignition Temperature: 245 °C

-Viscosity: 1.65 cP

-Surface Tension: 40.7 dynes/cm


N-Methyl Pyrrolidinone is an essential solvent for fluorinated coatings.
N-Methyl Pyrrolidinone is a very slow-evaporating solvent.

N-Methyl Pyrrolidinone is a solvent for agricultural formulations and synthesis applications such as insecticides, fungicides, and herbicides.
N-Methyl Pyrrolidinone solvent, a lower alkyl pyrrolidone, is a potent and versatile aprotic solvent.


CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 0

-Hydrogen Bond Acceptor Count: 1

-Rotatable Bond Count: 0

-Heavy Atom Count: 7

-Formal Charge: 0

-Complexity: 90.1

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

-Chemical Classes: Solvents -> Other Solvents


N-Methyl Pyrrolidinone's high boiling point, low vapor pressure, and high stability make it an effective solvent in numerous industrial applications.
N-Methyl Pyrrolidinone can be used as a co-solvent with water, alcohol, and other organic substances.

N-Methyl Pyrrolidinone solvent is highly resistant to hydrolysis from pH 2-10, even at elevated temperatures.
N-Methyl Pyrrolidinone is a versatile water-miscible polar aprotic solvent.

N-Methyl Pyrrolidinone is freely soluble in polar and nonpolar solvents and should readily cross biological membranes.
N-Methyl Pyrrolidinone is quickly absorbed from human skin and gastrointestinal and respiratory tracts.

N-Methyl Pyrrolidinone is a stable solvent
N-Methyl Pyrrolidinone can undergo a number of chemical reactions.

N-Methyl Pyrrolidinone is resistant to hydrolysis under neutral conditions.
N-Methyl Pyrrolidinone can be reduced to 1-methyl pyrrolidine by borohydride.

N-Methyl Pyrrolidinone is colorless
N-Methyl Pyrrolidinone is light yellow liquid with amine odor

N-Methyl Pyrrolidinone is a versatile industrial solvent.
N-Methyl Pyrrolidinone is miscible with water and most common organic solvents.

N-Methyl Pyrrolidinone is used as a solvent in the petrochemical and plastics industries
N-Methyl Pyrrolidinone is non-volatile
N-Methyl Pyrrolidinone has the ability to dissolve various materials

N-Methyl Pyrrolidinone is denser than water.
N-Methyl Pyrrolidinone has a role as a polar aprotic solvent.

N-Methyl Pyrrolidinone is used in laboratory chemicals
N-Methyl Pyrrolidinone is used for the manufacture of: chemicals.

N-Methyl Pyrrolidinone is used in agriculture, forestry and fisheries applications
N-Methyl Pyrrolidinone can be used in some chemical processes

N-Methyl Pyrrolidinone is widely used in the automotive industry
N-Methyl Pyrrolidinone can be found in metal surface treatment products

N-Methyl Pyrrolidinone is used in the manufacture of polymers and coating products.
N-Methyl Pyrrolidinone is used in metal surface treatment products

N-Methyl Pyrrolidinone is colorless
N-Methyl Pyrrolidinone has a mild amine-like odor.


SYNONYMS:

1-METHYL-2-PYRROLIDINONE
872-50-4
N-Methylpyrrolidone
N-Methyl-2-pyrrolidone
1-methylpyrrolidin-2-one
Methylpyrrolidone
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidinone
M-Pyrol
N-Methylpyrrolidinone
1-Methylpyrrolidinone
1-Methylpyrrolidone
Methyl pyrrolidone
n-methyl-pyrrolidone
2-Pyrrolidinone, 1-methyl-
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
N-methylpyrrolidin-2-one
NMP
N-Methyl-gamma-butyrolactam
N-methyl pyrrolidone
1-methylpyrrolidine-2-one
N-methyl pyrrolidinone
Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidon
Methylpyrrolidinone
2-Pyrrolidinone, methyl-
Methylpyrrolidone
N-Methylpyrrolid-2-one
N-Methyl-alpha-pyrrolidinone
1-methyl-pyrrolidin-2-one
N-Methyl-.alpha.-pyrrolidone
N-Methyl-.gamma.-butyrolactam
N-Methyl-.alpha.-pyrrolidinone
1-Methyl-2-pyrrolidinone, anhydrous
1-Methyl-2-pyrrolidinone
N 0131
26876-92-6
pharmasolve
N-Methylpyrrolidon
CAS-872-50-4
CCRIS 1633
N-methyl-pyrrolidinone
Methylpyrrolidone, N-
Pyrrolidinone, methyl-
N-Methyl-2-pyrrolidon
1-methyl-2-pyrolidone
EINECS 212-828-1
N-methyl-pyrrolidin-2-one
AI3-23116
N-methylpyrolidone
N-methypyrrolidone
Max-1 peptide
Pyrol M
N-methylpirrolidone
1methylpyrrolidinone
n-methyl pyrrolidon
n-methylbutyrolactam
N-methy pyrrolidone
N-methyl-pyrolidone
N-methyl-pyrrolidon
N-methylpyrolidinone
1-methylpyrolidinone
Microposit 2001
n-methylpyrollidinone
N-Methylpyrrolidione
N-methlypyrrolidinone
N-methyl pirrolidone
N-methyl pyrollidone
N-methyl-pyrollidone
N-methylpyrrolidone-
1-methyl pyrrolidone
1-methyl-pyrrolidone
methyl-2-pyrrolidone
N-methy pyrrolidinone
N-methyl pyrolidinone
N-methyl-pyrolidinone
N-methyl- pyrrolidone
N-methylpyrro-lidinone
N-methylpyrroli-dinone
N-methylpyrrolidin-one
1-methyl-pyrrolidinone
methylpyrrolidin-2-one
N-methy-2-pyrrolidone
N-methyl 2-pyrolidone
N-methyl-2-pyrolidone
3p1d
N-methyl 2-pyrrolidone
N-methyl-2-pyrollidone
1-methyl-2-pirrolidone
1-methyl-2-pyroldinone
1-methylpyrrolid-2-one
1methyl-2-pyrrolidinone
n-methylpyrrolidine-2one
N-methyl-2-pyrolidinone
N-methyl-2-pyrrolidinon
N-methylpyrolidin-2-one
1-methy-2-pyrrolidinone
1-methyl-2-pyrolidinone
N-methyl 2-pyrrolidinone
N-methyl-2-pyrollidinone
N-methyl-pyrrolid-2-one
N-methylpyrollidin-2-one
1 -methyl-2-pyrrolidone
1-methyl 2-pyrrolidinone
1-methyl-2-pyrollidinone
1-methyl-pyrrolin-2-one
N-Methylpyrrolidone-(2)
NMP, N-Methylpyrrolidone
1-Methyl-pyrrolidin-2one
N-methylpyrrolidine-2-one
N-methyl -2-pyrrolidinone
1 -methyl-2-pyrrolidinone
1-methyl -2-pyrrolidinone
1-methyl-2- pyrrolidinone
EC 212-828-1
2-Pyrrolidone, 1-methyl-
1-methyl-pyrrolidine-2-one
1-N-methyl-2-pyrrolidinone
N-methyl-pyrrolidin -2-one
30207-69-3
1-Methylazacyclopentane-2-one
GTPL9520
METHYL PYRROLIDONE [II]
1-Methyl-2- pyrrolidin-2-one
1-METHYLPYRROLIDONE [MI]
METHYL PYRROLIDONE [INCI]
METHYLPYRROLIDONE
N-METHYLPYRROLIDONE
1-Methyl-2-pyrrolidinone, 99.5%
N-Methyl pyrrolidon
N-METHYLPYRROLIDONE
1-METHYL-2-PYRROLIDINONE
N-METHYLPYRROLIDONE
-PYRROLIDONE,1-METHYL MFC5 H9 N1 O1
A842053
1-Methyl-2-pyrrolidinone
2,5-Dichloro-4,6-dimethyl pyridine-3-carbonitrile
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone
Methylpyrrolidone
N-Methylpyrrolidone
1-Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone (NMP)
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylpyrrolidin-2-one
1-Methylpyrrolidinone
1-Methylpyrrolidone
2-Pyrrolidinone, 1-methyl-
AgsolEx 1
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
n-Methyl-2-pyrrolidone
N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone
1-mehyl-2-pyrrolodone
1-Methyl 2-pyrrolidone
1-methyl 2-pyrrolidone
1-Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidon
1-Methyl-2-Pyrrolidone
1-Methyl-2-pyrrolidone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone (NMP)
1-methylpyrrolidin-1-one
1-methylpyrrolidin-2-one
1-methylpyrrolidin-2-one,N-METHYLPYRROLIDONE, 1-Methyl-2-pyrrolidinone, N-METHYL-2-PYRROLIDONE
1-methylpyrrolidone
1-méthyl-2-pyrrolidone
1-O-butyl 2-O-(phenylmethyl) benzene-1,2-dicarboxylate
2-Pyrrolidinone, 1-methyl-
2-Pyrrolidone, 1-methyl
Methyl pyrrolidone
METHYL-N 2-PYRROLIDONE
n methyl 2 pyrrolidone
N-Methyl pyrolidone
N-methyl-2-pyrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidon
N-METHYL-2-PYRROLIDONE
N-Methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
n-methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone
N-Methylpyrrolidone
N-Methylpyrrolidone
NMP
NMP
NMP (n-methyl-2-pyrrolidone)

1-Methyl-2-pyrrolidinone; 1-Methyl-5-Pyrrolidinone; Methylpyrrolidone; N-Methylpyrrolidone; N-Methyl-2-Pyrrolidone; NMP; 1-Methyl-2-pyrrolidone; m-pyrrole; 1-Methylpyrrolidinone; N-methylpyrrolidinone; N-Methyl-2-pyrrolidinone CAS:872-50-4

n-Methyl-2-pyrrolidone (NMP) is a highly polar aprotic solvent with the chemical formula C5H9NO.
n-Methyl-2-pyrrolidone is a colorless to light yellow liquid with a slightly amine-like odor.
n-Methyl-2-pyrrolidone is also known by its IUPAC name, N-methylpyrrolidone.

CAS Number: 872-50-4
EC Number: 212-828-1



APPLICATIONS


n-Methyl-2-pyrrolidone is commonly used as a solvent for various applications.
n-Methyl-2-pyrrolidone is used as a cleaning agent in the electronics industry.
n-Methyl-2-pyrrolidone is used as a solvent in the production of pharmaceuticals and agrochemicals.

n-Methyl-2-pyrrolidone is used as a reaction medium in chemical synthesis.
n-Methyl-2-pyrrolidone is used in the production of polymer fibers, films, and coatings.

n-Methyl-2-pyrrolidone is used as a solvent in the production of lithium-ion batteries.
n-Methyl-2-pyrrolidone is used in the production of photoresist materials.

n-Methyl-2-pyrrolidone is used as a solvent in the extraction of oil and gas.
n-Methyl-2-pyrrolidone is used in the production of printing inks and dyes.
n-Methyl-2-pyrrolidone is used in the production of adhesives and sealants.

n-Methyl-2-pyrrolidone is used as a solvent in the production of paints and coatings.
n-Methyl-2-pyrrolidone is used as a stripping agent in the semiconductor industry.

n-Methyl-2-pyrrolidone is used in the production of flavors and fragrances.
n-Methyl-2-pyrrolidone is used as a solvent in the production of herbicides and insecticides.

n-Methyl-2-pyrrolidone is used as a reaction solvent in the production of fine chemicals.
n-Methyl-2-pyrrolidone is used as a wetting agent in the production of ceramics.

n-Methyl-2-pyrrolidone is used in the production of electrolytes for lithium-ion batteries.
n-Methyl-2-pyrrolidone is used as a solvent in the production of water treatment chemicals.
n-Methyl-2-pyrrolidone is used in the production of resins and polymers.

n-Methyl-2-pyrrolidone is used as a solvent in the production of metal coatings.
n-Methyl-2-pyrrolidone is used as a reaction solvent in the production of pharmaceutical intermediates.

n-Methyl-2-pyrrolidone is used in the production of specialty chemicals.
n-Methyl-2-pyrrolidone is used as a solvent in the production of fuel additives.

n-Methyl-2-pyrrolidone is used in the production of food additives.
n-Methyl-2-pyrrolidone is used as a reaction solvent in the production of agrochemical intermediates.
n-Methyl-2-pyrrolidone is widely used as a solvent in various industries, including electronics, pharmaceuticals, and petrochemicals.

n-Methyl-2-pyrrolidone is used as a solvent in the production of polymers, resins, and coatings.
n-Methyl-2-pyrrolidone is a popular solvent for the manufacture of lithium-ion batteries.

n-Methyl-2-pyrrolidone is also used in the production of polyvinyl chloride (PVC) and other thermoplastic resins.
n-Methyl-2-pyrrolidone is used in the production of polyurethane foam and coatings.

n-Methyl-2-pyrrolidone is also used as a solvent in the production of pharmaceuticals, such as antibiotics and anti-inflammatory drugs.
n-Methyl-2-pyrrolidone is a commonly used solvent for the purification of proteins and nucleic acids.
n-Methyl-2-pyrrolidone is used in the extraction of natural products and flavors from plant materials.

n-Methyl-2-pyrrolidone is used in the production of pesticides, herbicides, and other agrochemicals.
n-Methyl-2-pyrrolidone is used in the textile industry as a dyeing and finishing agent.

n-Methyl-2-pyrrolidone is used as a solvent in the printing industry, particularly for the production of high-quality prints.
n-Methyl-2-pyrrolidone is used as a cleaning solvent for various industrial equipment and machinery.

n-Methyl-2-pyrrolidone is used as a solvent for the synthesis of organic compounds, such as pharmaceutical intermediates and specialty chemicals.
n-Methyl-2-pyrrolidone is used as a lubricant in metalworking and machining applications.
n-Methyl-2-pyrrolidone is used in the production of adhesives and sealants.

n-Methyl-2-pyrrolidone is a commonly used solvent for the cleaning and maintenance of electronic components and devices.
n-Methyl-2-pyrrolidone is used as a co-solvent in water-based coatings and inks.

n-Methyl-2-pyrrolidone is used as a reaction medium in various chemical reactions, such as polymerization and hydrogenation.
n-Methyl-2-pyrrolidone is used as a solvent for the formulation of personal care and cosmetic products.
n-Methyl-2-pyrrolidone is used as a carrier solvent for various flavors and fragrances.

n-Methyl-2-pyrrolidone is used in the production of photoresist materials for the semiconductor industry.
n-Methyl-2-pyrrolidone is used as a solvent for the production of graphene and other advanced materials.

n-Methyl-2-pyrrolidone is used in the production of specialty chemicals, such as surfactants and detergents.
n-Methyl-2-pyrrolidone is used as a solvent for the extraction and separation of rare earth elements.
n-Methyl-2-pyrrolidone is used in the production of inkjet inks and toners.


n-Methyl-2-pyrrolidone (NMP) is a versatile chemical that has many applications in various industries.
Some of its common applications include:


Solvent:

n-Methyl-2-pyrrolidone is used as a solvent for many chemicals, including polymers, resins, and dyes.


Pharmaceutical industry:

n-Methyl-2-pyrrolidone is used as a solvent and a carrier for drugs.


Electronics industry:

n-Methyl-2-pyrrolidone is used as a cleaning agent for electronic components.


Polymer industry:

n-Methyl-2-pyrrolidone is used as a solvent for polymerization reactions and as a dispersant for pigments and fillers.


Paint and coating industry:

n-Methyl-2-pyrrolidone is used as a solvent for resins, pigments, and additives in paints and coatings.


Adhesive industry:

n-Methyl-2-pyrrolidone is used as a solvent and a carrier for adhesives.


Chemical processing:

n-Methyl-2-pyrrolidone is used in chemical reactions, such as esterification, amidation, and hydrogenation.


Lithium-ion battery production:

n-Methyl-2-pyrrolidone is used as a solvent for the electrode materials and the electrolyte in lithium-ion batteries.


Petrochemical industry:

n-Methyl-2-pyrrolidone is used as a solvent for the separation of various chemicals in the petrochemical industry.


Textile industry:

n-Methyl-2-pyrrolidone is used as a solvent and a dye carrier in the textile industry.


Agriculture industry:

n-Methyl-2-pyrrolidone is used as a solvent for agricultural chemicals, such as pesticides and herbicides.


Printing industry:

n-Methyl-2-pyrrolidone is used as a solvent for inks and coatings in the printing industry.


Film industry:

n-Methyl-2-pyrrolidone is used as a solvent for film coatings and as a plasticizer for film materials.


Cleaning industry:

n-Methyl-2-pyrrolidone is used as a solvent for cleaning products.


Cosmetics industry:

n-Methyl-2-pyrrolidone is used as a solvent for cosmetic products, such as lotions and creams.


Food industry:

n-Methyl-2-pyrrolidone is used as a solvent for flavor and fragrance ingredients.


Rubber industry:

n-Methyl-2-pyrrolidone is used as a solvent for rubber and as a dispersant for fillers.


Textile printing industry:

n-Methyl-2-pyrrolidone is used as a solvent for textile printing pastes.


Water treatment industry:

n-Methyl-2-pyrrolidone is used as a solvent for water treatment chemicals.


Wood industry:

n-Methyl-2-pyrrolidone is used as a solvent for wood preservatives.


Gas processing industry:

n-Methyl-2-pyrrolidone is used as a solvent for natural gas processing.


Aerospace industry:

n-Methyl-2-pyrrolidone is used as a solvent for cleaning and degreasing aerospace components.


Automotive industry:

n-Methyl-2-pyrrolidone is used as a solvent for cleaning and degreasing automotive components.


Coating industry:

n-Methyl-2-pyrrolidone is used as a solvent for coatings and adhesives.


Construction industry:

n-Methyl-2-pyrrolidone is used as a solvent for construction chemicals, such as adhesives and sealants.


n-Methyl-2-pyrrolidone is used as a solvent in a wide range of industries, including pharmaceuticals, electronics, and coatings.
n-Methyl-2-pyrrolidone is an effective solvent for many organic and inorganic compounds, making it useful in a variety of chemical reactions and manufacturing processes.
n-Methyl-2-pyrrolidone is often used as a cleaning agent and degreaser due to its ability to dissolve oils and greases.

n-Methyl-2-pyrrolidone is used as a solvent in the production of polymers and resins, such as polyvinyl chloride and polyurethane.
n-Methyl-2-pyrrolidone is a common ingredient in paint strippers and graffiti removers due to its ability to dissolve and remove coatings and adhesives.

n-Methyl-2-pyrrolidone is used in the production of pharmaceuticals, including as a solvent for drug delivery systems and as a reactant in chemical syntheses.
n-Methyl-2-pyrrolidone is used as a solvent in the production of microelectronics and semiconductors.
n-Methyl-2-pyrrolidone is used in the production of rechargeable batteries and lithium-ion batteries.

n-Methyl-2-pyrrolidone is used in the production of high-performance fibers and films, such as those used in bulletproof vests and window films.
n-Methyl-2-pyrrolidone is used as a solvent in the production of flavors and fragrances.

n-Methyl-2-pyrrolidone is used in the production of pesticides and herbicides, as well as in the formulation of insect repellents.
n-Methyl-2-pyrrolidone is used as a solvent and extractant in the production of natural products, such as essential oils and plant extracts.

n-Methyl-2-pyrrolidone is used in the production of adhesives and sealants, as well as in the formulation of caulks and sealants.
n-Methyl-2-pyrrolidone is used in the production of printing inks and toners.

n-Methyl-2-pyrrolidone is used in the production of surfactants and detergents.
n-Methyl-2-pyrrolidone is used as a solvent in the production of photographic chemicals and film.
n-Methyl-2-pyrrolidone is used in the production of rubber and elastomers.

n-Methyl-2-pyrrolidone is used as a solvent in the production of flavors and fragrances.
n-Methyl-2-pyrrolidone is used as a cleaning agent and degreaser in the automotive industry.

n-Methyl-2-pyrrolidone is used in the production of industrial lubricants and hydraulic fluids.
n-Methyl-2-pyrrolidone is used as a solvent in the production of personal care products, such as shampoos and lotions.

n-Methyl-2-pyrrolidone is used as a solvent in the production of cleaning products, such as household cleaners and disinfectants.
n-Methyl-2-pyrrolidone is used in the production of food additives, such as emulsifiers and stabilizers.

n-Methyl-2-pyrrolidone is used as a solvent in the production of textile and leather chemicals, such as dyes and tanning agents.
n-Methyl-2-pyrrolidone is used as a solvent in the production of construction chemicals, such as concrete additives and sealers.



DESCRIPTION


n-Methyl-2-pyrrolidone (NMP) is a highly polar aprotic solvent with the chemical formula C5H9NO.
n-Methyl-2-pyrrolidone is a colorless to light yellow liquid with a slightly amine-like odor.
n-Methyl-2-pyrrolidone is also known by its IUPAC name, N-methylpyrrolidone.

n-Methyl-2-pyrrolidone is a clear and colorless to pale yellow liquid.
n-Methyl-2-pyrrolidone is a highly polar solvent with a high boiling point.
n-Methyl-2-pyrrolidone has a slightly amine-like odor and a bitter taste.

n-Methyl-2-pyrrolidone is miscible with water and many organic solvents.
n-Methyl-2-pyrrolidone is a versatile solvent used in various industries.

n-Methyl-2-pyrrolidone is commonly used in the production of electronics, pharmaceuticals, and polymers.
n-Methyl-2-pyrrolidone is a strong solvent for many organic compounds.

n-Methyl-2-pyrrolidone is also used as a solvent for dyes, resins, and pesticides.
The high polarity of n-Methyl-2-pyrrolidone makes it an excellent choice for dissolving polymers and plastics.
n-Methyl-2-pyrrolidone has a low vapor pressure, which makes it useful in high-temperature processes.

n-Methyl-2-pyrrolidone is also used as a co-solvent to improve the solubility of other solvents.
n-Methyl-2-pyrrolidone is considered a safer alternative to many chlorinated solvents.
n-Methyl-2-pyrrolidone has a high boiling point of 202°C, which makes it useful for high-temperature applications.

n-Methyl-2-pyrrolidone is also used as a cleaning agent for metal surfaces and electronic components.
n-Methyl-2-pyrrolidone is a key ingredient in the production of lithium-ion batteries.

n-Methyl-2-pyrrolidone is also used in the production of synthetic fibers, such as nylon and spandex.
n-Methyl-2-pyrrolidone is a common ingredient in paint strippers and varnish removers.

n-Methyl-2-pyrrolidone is also used as a solvent in the production of agrochemicals and herbicides.
The solvent properties of n-Methyl-2-pyrrolidone make it useful in the production of adhesives and sealants.
n-Methyl-2-pyrrolidone is also used as a solvent in the printing industry.

n-Methyl-2-pyrrolidone is used as a solvent for the extraction of chemicals and pharmaceuticals.
n-Methyl-2-pyrrolidone is an excellent solvent for certain proteins and enzymes.

n-Methyl-2-pyrrolidone is also used in the production of carbon fibers and other high-performance materials.
n-Methyl-2-pyrrolidone is considered a low-toxicity solvent with a good safety profile.
n-Methyl-2-pyrrolidone is an important solvent in many industrial applications.



PROPERTIES


Chemical formula: C5H9NO
Molecular weight: 99.13 g/mol
Physical state: clear, colorless to slightly yellow liquid
Odor: amine-like
Melting point: -24.6 °C (-12.3 °F)
Boiling point: 202 °C (396 °F)
Density: 1.027 g/cm3 at 25 °C (77 °F)
Solubility: miscible with water, alcohols, ethers, ketones, and many organic solvents
Viscosity: 3.8 cP at 25 °C (77 °F)
Vapor pressure: 0.6 mmHg at 25 °C (77 °F)
Flash point: 94 °C (201 °F)
Autoignition temperature: 485 °C (905 °F)
Refractive index: 1.466 at 20 °C (68 °F)
Dielectric constant: 32.7 at 25 °C (77 °F)
Surface tension: 34.8 mN/m at 20 °C (68 °F)
Heat of vaporization: 43.2 kJ/mol at normal boiling point
Heat of combustion: -3.33 MJ/mol
pH: neutral (pH 7)
Acidity: low
Basicity: low
Toxicity: low acute toxicity, but can cause skin and eye irritation, and may be harmful if ingested or inhaled
Flammability: combustible liquid
Reactivity: stable under normal conditions, but may react with strong oxidizing agents and acids
Miscibility with water: complete
Hygroscopicity: absorbs moisture from air.



FIRST AID


Inhalation:

Move the person to fresh air immediately.
If the person is not breathing, administer artificial respiration and seek immediate medical attention.

If breathing is difficult, give oxygen and seek immediate medical attention.
Do not give anything by mouth to an unconscious person.


Skin Contact:

Remove any contaminated clothing and rinse the affected area thoroughly with water for at least 15 minutes.
If irritation occurs or persists, seek medical attention immediately.
Wash contaminated clothing thoroughly before reuse.


Eye Contact:

Immediately flush the eyes with plenty of water for at least 15 minutes, lifting the upper and lower eyelids occasionally.
Seek immediate medical attention if eye irritation persists.


Ingestion:

Rinse mouth and lips thoroughly with water.
Do not induce vomiting unless directed to do so by medical personnel.
Seek immediate medical attention.
Never give anything by mouth to an unconscious person.


General First Aid Measures:

Remove contaminated clothing and wash it before reuse.
Always wash hands thoroughly after handling n-Methyl-2-pyrrolidone.
If exposed to the substance, it is important to seek medical attention immediately, especially if any symptoms are present.



HANDLING AND STORAGE


Handling:

Wear suitable protective clothing, gloves, and eye/face protection.
Avoid contact with skin, eyes, and clothing.
Use in a well-ventilated area.

Keep away from sources of ignition.
Avoid inhalation of vapors and spray.

Use only in areas with appropriate exhaust ventilation.
Do not eat, drink, or smoke while using the chemical.
Wash hands thoroughly with soap and water after handling.


Storage:

Store in a cool, dry, and well-ventilated area.
Keep away from heat, sparks, open flames, and other sources of ignition.

Keep containers tightly closed and properly labeled.
Store away from oxidizing agents, acids, and reducing agents.
Keep containers away from direct sunlight.

Store separately from food and animal feed.
Store in a secure area away from children and unauthorized personnel.
Do not store near combustible materials.



SYNONYMS


NMP
1-Methyl-2-pyrrolidinone
M-Pyrol
N-Methylpyrrolidone
N-Methyl-2-pyrrolidine
1-Methyl-2-pyrrolidine
1-Methylpyrrolidin-2-one
N-Methyl-2-pyrrolidone, monosodium salt
N-Methyl-2-pyrrolidone, disodium salt
N-Methyl-2-pyrrolidone, trisodium salt
N-Methyl-2-pyrrolidone, potassium salt
N-Methyl-2-pyrrolidone, lithium salt
N-Methyl-2-pyrrolidone, cesium salt
N-Methyl-2-pyrrolidone, rubidium salt
N-Methyl-2-pyrrolidone, calcium salt
N-Methyl-2-pyrrolidone, magnesium salt
N-Methyl-2-pyrrolidone, barium salt
N-Methyl-2-pyrrolidone, zinc salt
N-Methyl-2-pyrrolidone, copper salt
N-Methyl-2-pyrrolidone, aluminum salt
N-Methyl-2-pyrrolidone, iron salt
N-Methyl-2-pyrrolidone, nickel salt
N-Methyl-2-pyrrolidone, cobalt salt
N-Methyl-2-pyrrolidone, silver salt
N-Methyl-2-pyrrolidone, gold salt
1-Methyl-2-pyrrolidinone
N-Methylpyrrolidone
NMP
Pyrrolidone, 1-methyl-2-
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidine
Methylpyrrolidone
NSC 8796
CCRIS 5086
FEMA 3715
BRN 1207953
AI3-02923
LS-59436
AKOS003644230
DSSTox_CID_7847
1-Methylpyrrolidin-2-one
1-Methyl-2-pyrrolidone
N-Methylpyrrolidin-2-one
M-Pyrol
M-Pyrol 100
Dow NMP
NMP-Solvent
Cytosol 200
Cyclomethylonone
1-Methyl-2-pyrrolidinone
N-Methylpyrrolidone
N-Methylpyrrolidinone
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidine
N-Methylpyrrolidine-2-one
M-Pyrol
NSC 62786
Pharmasolve
Reomax
Solvitose
Suvarose
UNII-95TI3G3A3K
1-Methyl-2-pyrrolidinonum
2-Pyrrolidinone, 1-methyl
5-Methyl-4-pyrrolidone
Bionolve MP
Dow MP
EINECS 211-443-9
Ketasolve
MP 200
M-Pyrol MP
N-Methylbutyrolactam
Pyrrolidone N-methyl

N-Methyl-2-pyrrolidone is an organic compound consisting of a 5-membered lactam.
N-Methyl-2-pyrrolidone is a colorless liquid, although impure samples can appear yellow.
N-Methyl-2-pyrrolidone is miscible with water and with most common organic solvents.


CAS Number: 872-50-4
EC Number: 212-828-1
MDL number: MFCD00003193
Chemical formula: C5H9NO


N-Methyl-2-pyrrolidone also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-Methyl-2-pyrrolidone is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).
N-Methylpyrrolidone, also known as NMP or 1-methyl-2-pyrrolidone).


N-Methyl-2-pyrrolidone produced is an aprotic, highly polar organic solvent used in a variety of industries and applications.
N-Methyl-2-pyrrolidone is highly hygroscopic and easily absorbs moisture in the air.
N-Methyl-2-pyrrolidone is chemically inactive and non-corrosive to other metals such as carbon steel and aluminum, except for copper.
N-Methyl-2-pyrrolidone is a polar solvent with outstanding characteristics.


N-Methyl-2-pyrrolidone has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.
N-Methyl-2-pyrrolidone is a 5-member-ring compound containing nitrogen.
N-Methyl-2-pyrrolidone has a wide range of uses due to the following excellent characteristics.


N-Methyl-2-pyrrolidone is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).
Organic and inorganic substances are highly soluble in it.
N-Methyl-2-pyrrolidone mixes with water in all proportions.


N-Methyl-2-pyrrolidone has a high flash point compared to similar solvents.
The boiling point is high, the freezing point is low, and handling is easy.
N-Methyl-2-pyrrolidone is chemically and thermally stable, and not corrosive.
N-Methyl-2-pyrrolidone applications in the electronics field have expanded in recent years.


N-Methyl-2-pyrrolidone's high polarity and high solvency power along with our high purity, high-grade production technology enable the high performance needed in this field.
N-Methyl-2-pyrrolidone can dissolve organic and inorganic compounds equally well or better than chlorofluorocarbon solvents.
N-Methyl-2-pyrrolidone is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


N-Methyl-2-Pyrrolidone is a pale yellow organic compound and is a non-flammable product.
N-Methyl-2-pyrrolidone is miscible with water and most other solvents, always test a little and see how it mixes.
N-Methyl-2-pyrrolidone is denser than water at 1.03g/cc with a boiling range of 56 ºC.
N-Methyl-2-pyrrolidone is a flammable organic liquid consisting of a 5-membered lactam.


N-Methyl-2-pyrrolidone is available in various quantities and reagent grades, it is a dipolar aprotic solvent with petrochemical, plastic, and pharmaceutical applications.
N-methyl-2-pyrrolidone (NMP-EL), powerful, aprotic solvent.
N-Methyl-2-pyrrolidone has high solvency, low volatility, high boiling, high flash point and low vapor pressure.


N-Methyl-2-pyrrolidone is a liquid carries a mild amine-like odor.
N-Methyl-2-pyrrolidone shows high chemical and thermal stability, miscible with water at all temperatures.
The global N-Methyl-2-pyrrolidone Market size was estimated at USD 1.07 billion in 2015 and is expected to witness significant growth over the forecast period, primarily owing to the rising demand from key application segments, such as oil & gas (petrochemical), pharmaceuticals and electronics, among others.


This growth can be attributed to the expansion of the overall petrochemical industry.
During the period 2017 - 2021, the spending on downstream asset maintenance is expected to witness a growth of 7%, compared to that in 2012 - 2016, to reach USD 336 billion.
This growth can be attributed to greenfield and brownfield expansion projects.


Asia Pacific and North America together account for more than 60% of this spending.
Such a huge expansion in the petrochemical industry will certainly boost the demand for N-Methyl-2-pyrrolidone over the forecast period.
N-Methyl-2-pyrrolidone is a common solvent and drug vehicle.
More recently N-Methyl-2-pyrrolidone has been identified as a candidate bromodomain ligand with antineoplastic and immunomodulatory activity.


Mechanistically N-Methyl-2-pyrrolidone appears to be a low-affinity, broad-spectrum acetyllysine mimetic, but with apparent comparable ligand efficiency to that of larger rationally developed compounds such as (+)-JQ1 because of its very low molecular weight.
N-Methyl-2-pyrrolidone, also know as 1-Methyl-2-pyrrolidone; N-Methylpyrrolidone; N-Methylpyrrolidinone.
N-Methyl-2-pyrrolidone is a polar solvent with high boiling point, low viscosity, high chemical and thermal stability.


N-Methyl-2-pyrrolidone has a good solvency for a wide range of inorganic and organic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.
N-Methyl-2-pyrrolidone belongs to the class of organic compounds known as n-alkylpyrrolidines.
N-Methyl-2-pyrrolidone is a versatile solubilizer for one-component systems.


N-Methyl-2-pyrrolidone is a water-miscible polar aprotic solvent with high interfacial activity.
N-Methyl-2-pyrrolidone is a high boiling, polar aprotic, low viscosity liquid.
N-Methyl-2-pyrrolidone has good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has high chemical and thermal stability.


N-Methyl-2-pyrrolidone is a polar aprotic solvent with similar solvent properties as DMF, DMA, and DMSO.
N-Methyl-2-pyrrolidone is miscible with water.
N-Methyl-2-pyrrolidone is a versatile industrial solvent.
The sum of import and export of N-Methyl-2-pyrrolidone in and into Europe is estimated to be between 10,000 and 100,000 tons.



USES and APPLICATIONS of N-METHYL-2-PYRROLIDONE:
N-Methyl-2-pyrrolidone is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-Methyl-2-pyrrolidone is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.
Its good solvency properties have led to N-Methyl-2-pyrrolidone's use to dissolve a wide range of polymers.


Specifically, N-Methyl-2-pyrrolidone is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-Methyl-2-pyrrolidone is also used as a solvent in the commercial preparation of polyphenylene sulfide.
In the pharmaceutical industry, N-Methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes.


N-Methyl-2-pyrrolidone is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because NMP has a unique ability to dissolve polyvinylidene fluoride binder.
Due to N-Methyl-2-pyrrolidone's toxicity and high boiling point, there is much effort to replace it in battery manufacturing with other solvent(s), like water.


N-Methyl-2-pyrrolidone is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of N-Methyl-2-pyrrolidone can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.


Release to the environment of N-Methyl-2-pyrrolidone can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
N-Methyl-2-pyrrolidone is used in the following products: metal surface treatment products, non-metal-surface treatment products, polymers and coating products.


Release to the environment of N-Methyl-2-pyrrolidone can occur from industrial use: formulation of mixtures and manufacturing of the substance.
N-Methyl-2-pyrrolidone is used in the following areas: scientific research and development, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.
N-Methyl-2-pyrrolidone is used for the manufacture of: chemicals.


Other release to the environment of N-Methyl-2-pyrrolidone is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


N-Methyl-2-pyrrolidone is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Other release to the environment of N-Methyl-2-pyrrolidone is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).


N-Methyl-2-pyrrolidone can be found in complex articles, with no release intended: vehicles and vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).
N-Methyl-2-pyrrolidone is widespread used by professional workers.
N-Methyl-2-pyrrolidone is used in the following products: pH regulators and water treatment products and laboratory chemicals.


Therefore N-Methyl-2-pyrrolidone is used in various industrial fields as a cleaning or release agent.
N-Methyl-2-pyrrolidone is replacing 1,1,1-trichloroethane in metal cleaning applications due to the world-wide environmental pollution problems associated with chlorinated solvents.
N-Methyl-2-pyrrolidone is used to produce fine chemicals from mass-produced chemicals.


N-Methyl-2-pyrrolidone is used as a solvent for chemicals and resins in the microelectronics and pharmaceutical industries.
N-Methyl-2-pyrrolidone is widely used to replace other solvents, e.g., for paint stripping and lube oil extraction.
N-Methyl-2-pyrrolidone is used as a solvent for pesticides, coatings, adhesives, dyes, pigments, polymers, and polyurethane foam cleanup.


N-Methyl-2-pyrrolidone is a solvent used in a variety of industries and applications such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning, and industrial/ domestic cleaning.
Due to its good solvency properties, N-Methyl-2-pyrrolidone is used to dissolve a wide range of polymers.
N-Methyl-2-pyrrolidone is used in the surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.


N-Methyl-2-pyrrolidone is used solvent for resins, acetylene, etc.
N-Methyl-2-pyrrolidone is used Pigment dispersant, petroleum processing, spinning agent for polyvinyl chloride, microelectronics industry plastic solvent applications, intermediate.
N-Methyl-2-pyrrolidone, also known as NMP or 1-methyl-2-pyrrolidone, is a solvent used in a range of products.


N-Methyl-2-pyrrolidone is used in electronics industry, coatings (polyamide-imide, epoxy, and polyurethane).
The 99.9% high purity N-Methyl-2-pyrrolidone is widely used in battery research and industry as a solvent for binder, slurry coating and electrode materials preparation.


Other applications of N-Methyl-2-pyrrolidone can be found for engineering polymers and coating resins, paint cleaning, recovery of 1,3-butadiene and acetylene and hydrogen sulfide absorption.
N-Methyl-2-pyrrolidone is used as a drug solubilizer and penetration enhancer in human and animal parenteral dosage forms.
N-Methyl-2-pyrrolidone is used as a versatile industrial solvent.


N-Methyl-2-pyrrolidone is currently approved for use only in veterinary pharmaceuticals.
N-Methyl-2-pyrrolidone is used as solvent in the production of polymers, paints, semiconductor materials and batteries.
Another important field of use of N-Methyl-2-pyrrolidone is as cleaning agent to remove plastic, oil and paints.


N-Methyl-2-pyrrolidone is widely used in advanced lubricating oil refining, polymer synthesis, insulating materials, pesticides, pigments and cleaning agents.
N-Methyl-2-pyrrolidone is used as a solvent for engineering polymers and coating resins.
The polar nature and the low surface tension of N-Methyl-2-pyrrolidone makes it also an excellent cleaning medium and paint stripping solvent.


-Uses at industrial sites:
N-Methyl-2-pyrrolidone is used in the following products: semiconductors, washing & cleaning products, metal surface treatment products and non-metal-surface treatment products.
N-Methyl-2-pyrrolidone is used in the following areas: formulation of mixtures and/or re-packaging.


-Electronics use of N-Methyl-2-pyrrolidone:
*Wax, flux removal
*Burr removal
*Electronic parts cleaning
*Semiconductor parts cleaning
*Solvent for lithium battery manufacturing
*Semiconductor photo-resist thinner
*Color filter photo-resist thinner


-Automotive uses of N-Methyl-2-pyrrolidone:
*Mold cleaning
*Metal (parts) cleaning


-Chemical uses of N-Methyl-2-pyrrolidone:
*Extract agent (acetylene, BTX, butadiene)
*Synthetic resin surface coating solvent
*Reaction solvents (PPS, polyimide, etc.)
*Equipment washing


-Optical uses of N-Methyl-2-pyrrolidone:
*Plastic lens manufacturing equipment cleaning


-Pharmaceutical and Agricultural Chemicals use of N-Methyl-2-pyrrolidone:
*Water-soluble solvent
*Cleaning
*Extraction


-Cosmetic Uses of N-Methyl-2-pyrrolidone:
*solvents
*surfactants



WHAT PRODUCTS CONTAIN N-METHYL-2-PYRROLIDONE?
*Paint Strippers:
N-Methyl-2-pyrrolidone is a key ingredient in a variety of paint and coating removers sold in the U.S.

*Paints and other coatings:
N-Methyl-2-pyrrolidone is also used in a range of coating products sold by popular retailers.

*Other Products:
Some adhesives, cleaners, dyes, inks, and pesticides also contain N-Methyl-2-pyrrolidone.



PREPARATION OF N-METHYL-2-PYRROLIDONE:
N-Methyl-2-pyrrolidone is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 200,000 to 250,000 tons are produced annually.



ALTERNATIVE PARENTS OF N-METHYL-2-PYRROLIDONE:
*Pyrrolidine-2-ones
*Tertiary carboxylic acid amides
*Lactams
*Azacyclic compounds
*Organopnictogen compounds
*Organonitrogen compounds
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF N-METHYL-2-PYRROLIDONE:
*Pyrrolidone
*2-pyrrolidone
*N-alkylpyrrolidine
*Tertiary carboxylic acid amide
*Carboxamide group
*Lactam
*Carboxylic acid derivative
*Azacycle
*Organic oxide
*Organopnictogen compound
*Organic oxygen compound
*Organic nitrogen compound
*Organooxygen compound
*Organonitrogen compound
*Carbonyl group
*Hydrocarbon derivative
*Aliphatic heteromonocyclic compound



COMPOUND TYPE N-METHYL-2-PYRROLIDONE:
*Amide
*Amine
*Household Toxin
*Industrial/Workplace Toxin
*Organic Compound
*Solvent
*Synthetic Compound



PHYSICAL and CHEMICAL PROPERTIES of N-METHYL-2-PYRROLIDONE:
Chemical formula: C5H9NO
Molar mass: 99.133 g·mol−1
Density: 1.028 g/cm3
Melting point: −24 °C (−11 °F; 249 K)
Boiling point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water: Soluble
Solubility in Ethanol, acetone, diethylether, ethyl acetate, chloroform, benzene: Soluble
log P: −0.40
Molecular Weight: 99.13
Boiling point: 202 °C (1013 hPa)
Density: 1.03 g/cm3 (25 °C)
Explosion limit: 1.3 - 9.5 %(V)
Flash point: 91 °C
Ignition temperature: 245 °C
Melting Point: -24.2 °C
pH value: 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure: 0.32 hPa (20 °C)
Solubility: 1000 g/l
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%

Density (g/ml) @ 20°C: 1.029-1.033
Refractive Index (20°C): 1.470-1.472
Boiling Range: 202-204°C
Water (KF): max. 0.1%
Boiling point: 202 °C (1013 hPa)
Density: 1.03 g/cm3 (25 °C)
Explosion limit: 1.3 - 9.5 %(V)
Flash point: 91 °C
Ignition temperature: 245 °C
Melting Point: -24.2 °C
pH value: 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure: 0.32 hPa (20 °C)
Solubility: 1000 g/l
Physical state: liquid
Colour: colourless - clear
Odour: faintly perceptible - like: - amine
Melting point/freezing point: -24,2 °C at 1.013 hPa (ECHA)
Boiling point or initial boiling point and boiling range: 204,3 °C at 1.016 hPa (ECHA)
Lower and upper explosion limit: 1,3 vol% (LEL) - 9,5 vol% (UEL)
Flash point: 91 °C at 1.013 hPa (ECHA)
Auto-ignition temperature: 251 °C at 1.013 hPa (ECHA)

Decomposition temperature: not relevant
pH: (value) 8,5 – 10 (in aqueous solution: 100 g/l, 20 °C)
Kinematic viscosity 1,613 mm²/s at 25 °C
Dynamic viscosity 1,661 mPa s at 25 °C
Solubility(ies): Water solubility 1.000 g/l at 20 °C (ECHA)
Partition coefficient:
Partition coefficient: n-octanol/water (log value): -0,46 (25 °C) (ECHA)
Soil organic carbon/water: (log KOC) 0,87 (ECHA)
Vapour pressure: 0,32 hPa at 20 °C 2,54 hPa at 50 °C
Density and/or relative density:
Density: 1,03 g /cm³ at 25 °C (ECHA)
Relative vapour density: 3,42 (air = 1)
Particle characteristics: not relevant (liquid)
Other safety parameters:
Oxidising properties: none
Other safety characteristics:
Miscibility: completely miscible with water
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.031
Refractive Index (20°C): 1.470-1.471
Boiling Range: 201-202°C
Non Volatile Matter: max. 0.0005%
Water (KF): max. 0.05%

Physical state and appearance: Liquid, colorless
Odour: Amine like
Odour Threshold: Not Available
Taste: Not Available
Color: Colourless or Light Yellow
pH (1% soln/Water): 7.7 – 8.0
Boiling Point: 202 °C / 395.6 °F @ 760 mmHg
Flash Point: 91 °C / 195.8 °F
Molecular Weight: 99.13 g/mol
Melting Point: -24 °C / -11.2 °F
Critical Temperature: 451°C (843.8°F)
Specific Gravity: 1.026 (Water = 1)
Vapor Pressure: 0 kPa (@ 20°C)
Vapor Density: 3.4 (Air = 1)
Vapor Pressure: 0.7 mbar @ 25 °C
Solubility: miscible
Autoignition Temperature: 346 °C / 654.8 °F
Viscosity: 1.67 mPa s at 20 °C
Other Information: Not Available
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -25.00 °C. @ 760.00 mm Hg
Boiling Point: 202.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.345000 mmHg @ 25.00 °C.
Vapor Density: 3.4 ( Air = 1 )
Flash Point: 187.00 °F. TCC ( 86.10 °C. )
logP (o/w): -0.380
Soluble in: water, 1.00E+06 mg/L @ 25 °C, water, 2.483e+005 mg/L @ 25 °C

Molecular Formula: C5H9NO
Molar Mass: 99.13
Density: 1.028 g/mL at 25 °C (lit.)
Melting Point: -24 °C (lit.)
Boling Point: 202 °C (lit.)81-82 °C/10 mmHg (lit.)
Flash Point: 187°F
Water Solubility: >=10 g/100 mL at 20 ºC
Solubility: ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
Vapor Presure: 0.29 mm Hg ( 20 °C)
Vapor Density: 3.4 (vs air)
Appearance: Liquid
Color: ≤20(APHA)
Odor: Slight amine odor
Maximum wavelength(λmax): ['283nm(MeOH)(lit.)']
Merck: 14,6117
BRN: 106420
pKa: -0.41±0.20(Predicted)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
Storage Condition: Store at +5°C to +30°C.
Stability: Stable, but decomposes upon exposure to light.
Sensitive: Hygroscopic
Explosive Limit: 1.3-9.5%(V)
Refractive Index: n20/D 1.479
Physical and Chemical Properties: Characteristics of colorless transparent oily liquid, slightly amine odor.
melting point: -24.4 ℃
boiling point: 203 ℃
relative density: 1.0260
refractive index: 1.486
flash point: 95 ℃



FIRST AID MEASURES of N-METHYL-2-PYRROLIDONE:
-Description of First Aid Measures:
*General information :
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*Eye Contact:
Check for and remove any contact lenses.
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes.
Get medical attention immediately.
*Skin Contact:
Wash with soap and water.
*Serious Skin Contact:
Not Available
*Inhalation:
If inhaled, remove to fresh air.
Get medical attention.
*Serious inhalation:
Not Available
*Swallowing:
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
Not Available



ACCIDENTAL RELEASE MEASURES of N-METHYL-2-PYRROLIDONE:
-Environmental precautions:
Do not let product enter drains.
-Methods and material for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of N-METHYL-2-PYRROLIDONE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further Information (Precautions):
Use water spray to cool unopened containers.



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-METHYL-2-PYRROLIDONE:
-Control Parameters:
--Components with workplace control parameters:
-Exposure Controls:
--Appropriate Engineering Controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
--Personal Protective Equipment:
*Eye/face protection:
Safety glasses with side-shields.
*Skin protection:
Handle with gloves.
Wash and dry hands.
-Control of Environmental Exposure:
Do not let product enter drains.



HANDLING and STORAGE of N-METHYL-2-PYRROLIDONE:
-Precautions for Safe Handling:
No smoking.
-Conditions for safe storage, including any incompatibilities:
Store it in cool place.
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of N-METHYL-2-PYRROLIDONE:
-Reactivity:
This material is not reactive under normal ambient conditions.
-Chemical stability:
The material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.



SYNONYMS:
1-Methylpyrrolidin-2-one
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone
N-Methylpyrrolidinone
Pharmasolve
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidone
NMP
M-Pyrol
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP
1-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylpyrrolidinone
2-Pyrrolidone, 1-methyl-
1-Methylazacyclopentane-2-one
1-Methylpyrrolidone
N-Methylpyrrolidone-(2)
N-Methylpyrrolid-2-one
Methylpyrrolidone
1-Methylazacyclopentan-2-one
Agsolex 1
N 0131
N-Methyl-gamma-butyrolactam
Micropure ultra
NSC 4594
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylpyrrolidinone
1-Methylpyrrolidone
2-Pyrrolidinone, 1-methyl-
M-Pyrol
Methylpyrrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methyl-gamma-butyrolactam
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP
Norleucine, 5-oxo-, DL
UN1993
NMP
N-methylpyrrolidinone
N-methyl-2-pyrrolinone
1-methyl-5-pyrrolidinone
methylpyrrolidone
N-methylpyrrolidone
composite constituent
1-Methyl-2-pyrrolidinone
1-Methylazacyclopentan-2-one
N-Methyl-alpha-pyrrolidinone
N-Methyl-alpha-pyrrolidone
N-Methyl-gamma-butyrolactam
NMP
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylpyrrolidone
AgsolEx 1
M-Pyrol
Microposit 2001
N 0131
N-Methyl-2-ketopyrrolidine
N-Methyl-γ-butyrolactam
N-Methylbutyrolactam
N-Methylpyrrolidone
NMP
NSC 4594
Pharmasolve
Pyrol M
SL 1332
N-methyl-2-pyrrolidone
NMP
NMP-T
NMP-EL
M-PYROL(R)
N-METHYLPYROLIDONE
N-Methylpyrrolidone
N-Methyl pyrrolidone
N-Methyl-pyrrolidone
N-METHYLPYRROLIDNONE
N-METHYLPYRROLIDINONE
1-Methyl-2-pyrrolidone
N-METHYLPYRROLID-2-ONE
N-Methyl-2-pyrrolidone
1-METHYL-2-PYRROLIDINONE
N-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone, anhydrous
N-Methyl-2-pyrrolidone Manufacturer
N-Methyl-2-pyrrolidinone 872-50-4 NMP
1-Methyl-2-pyrrolidinone 872-50-4 NMP
N-Methyl-2-pyrrolidinone
1-METHYL-2-PYRROLIDONE
REAGENT (ACS)1-METHYL-2-PYRROLIDONE
REAGENT (ACS)1-METHYL-2-PYRROLIDONE
REAGENT (ACS)
M-Pyrol
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone; NMP
1-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylpyrrolidinone
2-Pyrrolidone, 1-methyl-
1-Methylazacyclopentane-2-one
1-Methylpyrrolidone
N-Methylpyrrolidone-(2)
N-Methylpyrrolid-2-one
Methylpyrrolidone
1-Methylazacyclopentan-2-one
Agsolex 1
N 0131
N-Methyl-gamma-butyrolactam
Micropure ultra
NSC 4594

1-Methyl-2-pyrrolidinone; 1-Methyl-5-Pyrrolidinone; Methylpyrrolidone; N-Methylpyrrolidone; N-Methyl-2-Pyrrolidone; NMP; 1-Methyl-2-pyrrolidone; m-pyrrole; 1-Methylpyrrolidinone; N-methylpyrrolidinone; N-Methyl-2-pyrrolidinone; cas no:872-50-4

n-Methyl-2-Pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
n-Methyl-2-Pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water and with most common organic solvents.


CAS Number: 872-50-4
EC Number: 212-828-1
MDL number: MFCD00003193
Chemical formula: C5H9NO


n-Methyl-2-Pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
n-Methyl-2-Pyrrolidone (NMP) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


n-Methyl-2-Pyrrolidone (NMP) is a polar solvent with outstanding characteristics.
n-Methyl-2-Pyrrolidone (NMP) has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.


n-Methyl-2-Pyrrolidone (NMP) has a wide range of uses due to the following excellent characteristics.
n-Methyl-2-Pyrrolidone (NMP) is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).


n-Methyl-2-Pyrrolidone (NMP) is a 5-member-ring compound containing nitrogen.
Organic and inorganic substances are highly soluble in n-Methyl-2-Pyrrolidone (NMP).
n-Methyl-2-Pyrrolidone (NMP) mixes with water in all proportions.


n-Methyl-2-Pyrrolidone (NMP) has a high flash point compared to similar solvents.
The boiling point of n-Methyl-2-Pyrrolidone (NMP) is high, the freezing point is low, and handling is easy.
n-Methyl-2-Pyrrolidone (NMP) is chemically and thermally stable, and not corrosive.


n-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid.
n-Methyl-2-Pyrrolidone (NMP) has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.


n-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility.
This colorless, high boiling, high flash point and low vapor pressure liquid, n-Methyl-2-Pyrrolidone (NMP), carries a mild aminelike odor. n-Methyl-2-Pyrrolidone (NMP) has high chemical and thermal stability and is completely miscible with water at all temperatures.


n-Methyl-2-Pyrrolidone (NMP) is a common solvent and drug vehicle. More recently n-Methyl-2-Pyrrolidone (NMP) has been identified as a candidate bromodomain ligand with antineoplastic and immunomodulatory activity.
Mechanistically n-Methyl-2-Pyrrolidone (NMP) appears to be a low-affinity, broad-spectrum acetyllysine mimetic, but with apparent comparable ligand efficiency to that of larger rationally developed compounds such as (+)-JQ1 because of its very low molecular weight.


n-Methyl-2-Pyrrolidone (NMP) is a flammable organic liquid consisting of a 5-membered lactam.
Available in various quantities and reagent grades, n-Methyl-2-Pyrrolidone (NMP) is a dipolar aprotic solvent with petrochemical, plastic, and pharmaceutical applications.


n-Methyl-2-Pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
n-Methyl-2-Pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water and with most common organic solvents.


n-Methyl-2-Pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
n-Methyl-2-Pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
n-Methyl-2-Pyrrolidone (NMP) is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials.


n-Methyl-2-Pyrrolidone (NMP), also known as NMP or 1-methyl-2-pyrrolidone).
n-Methyl-2-Pyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as pain and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.


n-Methyl-2-Pyrrolidone (NMP) is produced and imported into the United States, with use estimated at over 184 million pounds per year.
EPA estimates that approximately 9 percent of total n-Methyl-2-Pyrrolidone (NMP) usage is for paint and coating removal products.
n-Methyl-2-Pyrrolidone (NMP), also known as NMP or 1-methyl-2-pyrrolidone, is a solvent used in a range of products.


The average consumer is most likely to encounter n-Methyl-2-Pyrrolidone (NMP) in paint strippers, even though safer alternatives exist.
n-Methyl-2-Pyrrolidone (NMP) has been closely linked to developmental impacts including miscarriages.
n-Methyl-2-Pyrrolidone (NMP) is a clear colorless liquid with a fish-like odor.


n-Methyl-2-Pyrrolidone (NMP) is a polar solvent with outstanding characteristics.
n-Methyl-2-Pyrrolidone (NMP) is a powerful solvent.
n-Methyl-2-Pyrrolidone (NMP) offers exceptional performance, broad solubility for resins, high chemical and thermal stability.


n-Methyl-2-Pyrrolidone (NMP) is recyclable by distillation, easily biodegradable and essentially non-toxic to aquatic life.
n-Methyl-2-Pyrrolidone (NMP) is completely soluble with water at all temperatures and is soluble with most organic solvents.
n-Methyl-2-Pyrrolidone (NMP) is a pale yellow organic compound.


n-Methyl-2-Pyrrolidone (NMP) is non-flammable.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water has a boiling range of 56ºC.
n-Methyl-2-Pyrrolidone (NMP), a lower alkyl pyrrolidone, is an extremely powerful and versatile aprotic solvent.


n-Methyl-2-Pyrrolidone (NMP) is extremely resistant to hydrolysis from pH 2-10, even at elevated temperatures.
Beyond these limits, hydrolysis to 4-(methylamino) butanoic acid occurs at a rate dependent on pH and temperature.
A large body of chemistry has been developed on the reactions of strong nucleophiles with n-Methyl-2-Pyrrolidone (NMP).


n-Methyl-2-Pyrrolidone (NMP) has a molecular formula of C5H9NO, and it is a colorless to light yellow transparent liquid with a slight ammonia odor.
n-Methyl-2-Pyrrolidone (NMP)'s boiling point is 204℃, flash point is 91℃, chroma HaZen≤25, refractive index N20D 1.468-1.471, density is 1.032-1.035.
n-Methyl-2-Pyrrolidone (NMP) is miscible in water at any ratio, it is soluble in ethanol, acetone, esters, halogenated hydrocarbons, aromatic hydrocarbons and other organic solvents, and it can completely mix with practically all solvents.


n-Methyl-2-Pyrrolidone (NMP) appears as a clear colorless liquid with a "fishlike" odor.
n-Methyl-2-Pyrrolidone (NMP) is denser than water.
The flash point of n-Methyl-2-Pyrrolidone (NMP) is 199°F.


n-Methyl-2-Pyrrolidone (NMP) is a clear colorless liquid with a fish-like odor.
n-Methyl-2-Pyrrolidone (NMP) is a pale yellow organic compound and is a non-flammable product.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water and most other solvents, always test a little and see how it mixes.


n-Methyl-2-Pyrrolidone (NMP) is denser than water at 1.03g/cc with a boiling range of 56 ºC.
n-Methyl-2-Pyrrolidone (NMP) is a polar aprotic solvent with similar solvent properties as DMF, DMA, and DMSO.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water.


n-Methyl-2-Pyrrolidone (NMP) is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones.
n-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility.
n-Methyl-2-Pyrrolidone (NMP) carries a mild amine-like odor.


n-Methyl-2-Pyrrolidone (NMP) has high chemical and thermal stability and is completely miscible with water at all temperatures.
n-Methyl-2-Pyrrolidone (NMP) can serve as a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons.
n-Methyl-2-Pyrrolidone (NMP) is both recyclable by distillation and readily biodegradable.


n-Methyl-2-Pyrrolidone (NMP) is not found on the Hazardous Air Pollutants (HAPs) list of the 1990 Clean Air Act Amendments.
n-Methyl-2-Pyrrolidone (NMP) is soluble in water.
n-Methyl-2-Pyrrolidone (NMP) is non flammable.


n-Methyl-2-Pyrrolidone (NMP) has high solvency, low volatility, high boiling, high flash point and low vapor pressure.
n-Methyl-2-Pyrrolidone (NMP) has liquid carries a mild amine-like odor. n-Methyl-2-Pyrrolidone (NMP) shows high chemical and thermal stability, miscible with water at all temperatures.


n-Methyl-2-Pyrrolidone (NMP) is one of the best and most versatile solvents to dissolve compounds with low aqueous solubility.
n-Methyl-2-Pyrrolidone (NMP) is the preferred solvent for long-acting in-situ forming depots.
n-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent.



USES and APPLICATIONS of n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
n-Methyl-2-Pyrrolidone (NMP) is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.


Its good solvency properties have led to n-Methyl-2-Pyrrolidone (NMP)'s use to dissolve a wide range of polymers.
Specifically, n-Methyl-2-Pyrrolidone (NMP) is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
n-Methyl-2-Pyrrolidone (NMP) is also used as a solvent in the commercial preparation of polyphenylene sulfide.


In the pharmaceutical industry, n-Methyl-2-Pyrrolidone (NMP) is used in the formulation for drugs by both oral and transdermal delivery routes.
n-Methyl-2-Pyrrolidone (NMP) is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because NMP has a unique ability to dissolve polyvinylidene fluoride binder.


Due to n-Methyl-2-Pyrrolidone (NMP)'s high boiling point, there is much effort to replace it in battery manufacturing with other solvent(s), like water.
n-Methyl-2-Pyrrolidone (NMP) is used in graffiti removal, paint stripping, coat removal, oven cleaning and electronic cleaning.
n-Methyl-2-Pyrrolidone (NMP) is often used to dissolve a wide range of polymers.


n-Methyl-2-Pyrrolidone (NMP) is used in petrochemical processing, engineering plastic coatings and agricultural chemicals.
n-Methyl-2-Pyrrolidone (NMP) has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.


n-Methyl-2-Pyrrolidone (NMP) is a solvent used in a variety of industries and applications such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning, and industrial/ domestic cleaning.
Due to its good solvency properties, n-Methyl-2-Pyrrolidone (NMP) is used to dissolve a wide range of polymers.


n-Methyl-2-Pyrrolidone (NMP) is used in the surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
n-Methyl-2-Pyrrolidone (NMP) is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


Other release to the environment of n-Methyl-2-Pyrrolidone (NMP) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).
n-Methyl-2-Pyrrolidone (NMP) can be found in complex articles, with no release intended: vehicles and vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).


n-Methyl-2-Pyrrolidone (NMP) is used in the following products: pH regulators and water treatment products and laboratory chemicals. n-Methyl-2-Pyrrolidone (NMP) is used in the following areas: scientific research and development, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.


Other release to the environment of n-Methyl-2-Pyrrolidone (NMP) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


n-Methyl-2-Pyrrolidone (NMP) is used for the manufacture of: chemicals.
n-Methyl-2-Pyrrolidone (NMP) is used in the following products: metal surface treatment products, non-metal-surface treatment products, polymers and coating products.


Release to the environment of n-Methyl-2-Pyrrolidone (NMP) can occur from industrial use: formulation of mixtures and manufacturing of the substance.
n-Methyl-2-Pyrrolidone (NMP) is used in the following products: semiconductors, washing & cleaning products, metal surface treatment products and non-metal-surface treatment products.


n-Methyl-2-Pyrrolidone (NMP) is used in the following areas: formulation of mixtures and/or re-packaging.
n-Methyl-2-Pyrrolidone (NMP) is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of n-Methyl-2-Pyrrolidone (NMP) can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.


Release to the environment of n-Methyl-2-Pyrrolidone (NMP) can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
n-Methyl-2-Pyrrolidone (NMP) is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).


n-Methyl-2-Pyrrolidone (NMP) is used Electronics, Paints & coatings, Polymer & plastic, Process solvents, Solvents/stripping agents, Wire wrappers.
n-Methyl-2-Pyrrolidone (NMP) is used as a solvent for engineering polymers and coating resins.
Additionally, the polar nature and the low surface tension of n-Methyl-2-Pyrrolidone (NMP) makes it an excellent cleaning medium and paint stripping solvent.


n-Methyl-2-Pyrrolidone (NMP) is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in.
Pharmaceuticals: n-Methyl-2-Pyrrolidone (NMP) can be used as solvent, extraction medium.
Industrial and household cleaning: n-Methyl-2-Pyrrolidone (NMP) is used for paint stripping, in graffiti removers, oven cleaners, in automotive and industrial cleaner formulations.


Agrochemicals: n-Methyl-2-Pyrrolidone (NMP) can be used as solvent during synthesis or as a formulation agent.
n-Methyl-2-Pyrrolidone (NMP) produced by Welinks is an aprotic, highly polar organic solvent used in a variety of industries and applications.
Due to its high solvency and low volatility, n-Methyl-2-Pyrrolidone (NMP) is used in automotive and industrial cleaners with solvents, including hydrocarbons, terpenes, propylene carbonate and propylene glycol ethers.


With its high boiling point, low vapor pressure and high stability, n-Methyl-2-Pyrrolidone (NMP) is an effective solvent in numerous industry applications and can be used as a co-solvent with water, alcohols, and other organic substances.
n-Methyl-2-Pyrrolidone (NMP) is also used as a reaction medium for polyamide-imide resins in wire coatings and as a solvent for urethanes and epoxies in water based coatings.


n-Methyl-2-Pyrrolidone (NMP) is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability.
n-Methyl-2-Pyrrolidone (NMP)is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins.


n-Methyl-2-Pyrrolidone (NMP) is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits.
n-Methyl-2-Pyrrolidone (NMP) can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze.


n-Methyl-2-Pyrrolidone (NMP) is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization.
n-Methyl-2-Pyrrolidone (NMP) is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization.


n-Methyl-2-Pyrrolidone (NMP) can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent.
n-Methyl-2-Pyrrolidone (NMP) is used in mediums for polymerization reactions such as engineering plastics and aramid fiber.


n-Methyl-2-Pyrrolidone (NMP) is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries.
high purity grade for ICP-MS detection.
n-Methyl-2-Pyrrolidone (NMP) is used for peptide synthesis.


n-Methyl-2-Pyrrolidone (NMP) is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials
n-Methyl-2-Pyrrolidone (NMP) is used Solvent for Lithium Battery Cathode Materials.


n-Methyl-2-Pyrrolidone (NMP) is an ideal solvent for the electronics industry and can be used in a wide range of ever growing applications.
n-Methyl-2-Pyrrolidone (NMP) is a versatile industrial solvent.
n-Methyl-2-Pyrrolidone (NMP) is currently approved for use only in veterinary pharmaceuticals.


n-Methyl-2-Pyrrolidone (NMP) is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations.
n-Methyl-2-Pyrrolidone (NMP) is used solvent for high-temperature resins; petrochemical processing, in the microelectronics fabrication industry, dyes and pigments, industrial and domestic cleaning compounds; agricultural and pharmaceutical formulations.


n-Methyl-2-Pyrrolidone (NMP) is a polar solvent that is used in organic chemistry and polymer chemistry.
Large scale applications of n-Methyl-2-Pyrrolidone (NMP) include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.


n-Methyl-2-Pyrrolidone (NMP) is useful for spectrophotometry, chromatography and ICP-MS detection.
n-Methyl-2-Pyrrolidone (NMP) is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.


n-Methyl-2-Pyrrolidone (NMP) has a role as a polar aprotic solvent.
n-Methyl-2-Pyrrolidone (NMP) is used in electronics industry, coatings (polyamide-imide, epoxy, and polyurethane).
n-Methyl-2-Pyrrolidone (NMP) has been approved as a solvent for slimicide application to food packaging materials.


n-Methyl-2-Pyrrolidone (NMP) is used as a general dipolar aprotic solvent, stable and unreactive.
n-Methyl-2-Pyrrolidone (NMP) is used for extraction of aromatic hydrocarbons from lubricating oils.
n-Methyl-2-Pyrrolidone (NMP) is used for carbon dioxide removal in ammonia generators.


n-Methyl-2-Pyrrolidone (NMP) is used as a solvent for polymerization reactions and polymers.
n-Methyl-2-Pyrrolidone (NMP) is used as a paint stripper.
n-Methyl-2-Pyrrolidone (NMP) is used for pesticide formulations.


Other non-industrial uses of n-Methyl-2-Pyrrolidone (NMP) are based on its properties as a dissociating solvent suitable for electrochemical and physical chemical studies.
Pharmaceutical applications make use of the properties of n-Methyl-2-Pyrrolidone (NMP) as a penetration enhancer for a more rapid transfer of substances through the skin.


-Petrochemical processing:
n-Methyl-2-Pyrrolidone (NMP) is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction, lube oil purification.


-Electronics:
n-Methyl-2-Pyrrolidone (NMP) is used as photoresist stripper, for defluxing, degreasing and cleaning.
n-Methyl-2-Pyrrolidone (NMP) is a solvent for the production of FCCL, polyamide/polyimide wire enamels, epoxy and polyurethane coatings.



WHAT PRODUCTS CONTAIN n-mETHYL-2-PYRROLIDONE (NMP):
*Paint Strippers:
n-Methyl-2-Pyrrolidone (NMP) is a key ingredient in a variety of paint and coating removers sold in the U.S.
*Paints and other coatings:
n-Methyl-2-Pyrrolidone (NMP) is also used in a range of coating products sold by popular retailers.
*Other Products:
Some adhesives, cleaners, dyes, inks, and pesticides also contain n-Methyl-2-Pyrrolidone (NMP).



PRODUCTION METHODS OF n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is manufactured by the reaction of buytrolactone with methylamine.
Other processes of n-Methyl-2-Pyrrolidone (NMP) include preparation by hydrogenation of solutions of maleic or succinic acids with methylamine.



CHEMICAL PROPERTIES OF n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is a colourless or light yellow liquid with an amine odour.
n-Methyl-2-Pyrrolidone (NMP) can undergo a number of chemical reactions even though it is accepted as a stable solvent.
n-Methyl-2-Pyrrolidone (NMP) is resistant to hydrolysis under neutral conditions, but strong acid or base treatment results in ring opening to 4-methyl aminobutyric acid.
n-Methyl-2-Pyrrolidone (NMP) can be reduced to 1-methyl pyrrolidine with borohydride.



REACTIVITY PROFILE OF n-mETHYL-2-PYRROLIDONE (NMP):
This amine, n-Methyl-2-Pyrrolidone (NMP), is a very mild chemical base.
n-Methyl-2-Pyrrolidone (NMP) does tend to neutralize acids to form salts plus water.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.



FEATURES AND BENEFFITS OF n-mETHYL-2-PYRROLIDONE (NMP):
* high interfacial activity
* solubilizer and penetration enhancer in human and veterinary injectable dosage forms
* dissolves a variety of poorly soluble APIs



PREPARATION OF n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 200,000 to 250,000 tons are produced annually.



STORAGE RECOMMENDATIONS OF n-mETHYL-2-PYRROLIDONE (NMP):
Keep n-Methyl-2-Pyrrolidone (NMP)t in a cool, dry, well-ventilated place, away from heat, ignition sources and incompatible substances.
n-Methyl-2-Pyrrolidone (NMP) should keep the container upright and tightly closed.
Physical damage to the container should be avoided.
Do not reuse the container.
Unwashed empty containers should be labelled as a warning.



PHYSICAL and CHEMICAL PROPERTIES of n-mETHYL-2-PYRROLIDONE (NMP):
Chemical formula: C5H9NO
Molar mass: 99.133 g·mol−1
Density: 1.028 g/cm3
Melting point: −24 °C (−11 °F; 249 K)
Boiling point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water: Soluble
Solubility in Ethanol, acetone, diethylether, ethyl acetate, chloroform, benzene: Soluble
log P: −0.40
Molecular Weight: 99.14
Appearance: Clear colorless liquid
Odor: Faint amine smell
Specific Gravity (25/4℃): 1.027
Viscosity(mPa･s) : 1.89（25℃）
Boiling Point (℃): 202
Freezing Point (℃): -23
Vapor specific gravity: 3.4
Flash Point (℃): 99 (open cup)
Autoignition Temperature (℃): 252
Physical state: clear, liquid
Color: colorless

Odor: amine-like
Melting point/freezing point:
Melting point/range: -24 °C
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 9,5 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 91 °C
Autoignition temperature :245 °C at 1.013 hPa - DIN 51794
Decomposition temperature: No data available
pH: 8,5 - 10,0 at 100 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 1,661 mPa.s at 25 °C
Water solubility: 1.000 g/l at 20 °C - soluble
Partition coefficient: n-octanol/water:
log Pow: -0,46 at 25 °C
Bioaccumulation is not expected.
Vapor pressure: 0,32 hPa at 20 °C
Density: 1,028 g/mL at 25 °C
Relative densit:y No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:

Conductivity: 0,2 - 0,4 µS/cm
Surface tension: 40,4 mN/m
Relative vapor density: 3,42 - (Air = 1.0)
Boiling point: 396°F
Molecular weight: 99.13
Freezing point/melting point: -9°F
Flash point: 204°F
Vapor density: 3.4
Specific gravity: 1.03
NFPA health rating: 2
NFPA fire rating: 2
NFPA reactivity rating: 0
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.033
Refractive Index (20°C): 1.470-1.472
Boiling Range: 202-204°C
Water (KF): max. 0.1%
Molecular Weight： 99.13110

Exact Mass： 99.13
EC Number： 212-828-1
UNII： JR9CE63FPM
ICSC Number： 0513
NSC Number： 4594
UN Number： 1993
DSSTox ID： DTXSID6020856
Color/Form： Clear liquid
HScode: 2933990090
PSA: 20.31000
XLogP3： 0.17650
Density： 1.027 g/cm3 @ Temp: 25 °C
Melting Point： -25 °C
Boiling Point： 202 °C @ Press: 760 Torr
Flash Point： 91ºC
Refractive Index： n20/D 1.479
Water Solubility： H2O: >=10 g/100 mL at 20 ºC
Storage Conditions： 2-8ºC
Vapor Pressure： 0.29 mm Hg ( 20 °C)
Vapor Density： 3.4 (vs air)
Explosive limit： vol% in air: 1.3.5
Odor： Mild amine odor
PH： pH = 7.7-8
Henrys Law Constant： 3.20e-09 atm-m3/mole
Experimental Properties：

Dipole moment at 25 °C: 4.09 debye
Dielectric constant at 25 °C: 32.3
Hydroxy radical rate constant = 7.4X10-11 cu cm/molecule-sec at 25 °C
Air and Water Reactions： Soluble in water.
Reactive Group： Amides and Imides
Autoignition Temperature： 655 °F (346 °C)|245 °C
Heat of Combustion： 719 kcal/mol
Heat of Vaporization： 127.3 kcal/Kg
Critical Temperature & Pressure：
Critical temperature = 451 °C
Critical pressure = 4.78 MPa
Empirical formula: C5H9NO
Molar mass (M): 99,13 g/mol
Density (D): 1,03 g/cm³
Boiling point (bp): 204,3 °C
Flash point (flp): 91 °C
Melting point (mp): -24,2 °C
CAS Number: 872-50-4
Molecular Weight: 99.13 g/mol
Appearance: Colorless liquid
Melting Point: -24 C
Boiling Point: 202 C
Density: 1.028 g/mL at 25 C

Melting point: -24 °C (lit.)
Boiling point: 202 °C (lit.) 81-82 °C/10 mmHg (lit.)
Density: 1.028 g/mL at 25 °C (lit.)
vapor density: 3.4 (vs air)
vapor pressure: 0.29 mm Hg ( 20 °C)
refractive index: n20/D 1.479
Flash point: 187 °F
storage temp.: Store at +5°C to +30°C.
solubility: ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
form: Liquid
pka: -0.41±0.20(Predicted)
color: ≤20(APHA)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
Odor: Slight amine odor
PH Range: 7.7 - 8.0
explosive limit: 1.3-9.5%(V)
Water Solubility: >=10 g/100 mL at 20 ºC
Sensitive: Hygroscopic
λmax: 283nm(MeOH)(lit.)
Merck: 14,6117
BRN: 106420
Stability: Stable, but decomposes upon exposure to light.
InChIKey: SECXISVLQFMRJM-UHFFFAOYSA-N
LogP: -0.46 at 25℃



FIRST AID MEASURES of n-mETHYL-2-PYRROLIDONE (NMP):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of n-mETHYL-2-PYRROLIDONE (NMP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of n-mETHYL-2-PYRROLIDONE (NMP):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of n-mETHYL-2-PYRROLIDONE (NMP):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: 60 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A-(P2)
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of n-mETHYL-2-PYRROLIDONE (NMP):
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
Take precautionary measures against static discharge.
*Hygiene measures:
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.
Moisture sensitive.



STABILITY and REACTIVITY of n-mETHYL-2-PYRROLIDONE (NMP):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available



SYNONYMS:
1-Methylpyrrolidin-2-one
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone
N-Methylpyrrolidinone
Pharmasolve
G N-Methyl-2-Pyrrolidone,
1-Methyl-2-Pyrrolidone,
1-Methyl-Pyrrolidine-2-one,
N-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidone
NMP
N-Methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone
NMP
M-PYROL
NMP; N-methylpyrrolidinone
N-methyl-2-pyrrolinone
1-methyl-5-pyrrolidinone
methylpyrrolidone
N-methylpyrrolidone
2-Pyrrolidinone,1-methyl-
2-Pyrrolidone,1-methyl-
1-Methyl-2-pyrrolidinone
N-Methylpyrrolidinone
1-Methyl-5-pyrrolidinone
NMP
N-Methyl-2-pyrrolidone
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methylpyrrolidone
M-Pyrol
1-Methylazacyclopentan-2-one
1-Methyl-2-pyrrolidone
Pyrol M
N-Methylpyrrolidone
AgsolEx 1
N 0131
Microposit 2001
N-Methyl-2-ketopyrrolidine
N-Methylbutyrolactam
Pharmasolve
SL 1332
NSC 4594
N-Methylpyrrolidine-2-one
M 0418
EKOS 1
NMP 1165
26138-58-9
53774-35-9
57762-46-6
M-Pyrol
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP
1-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylpyrrolidinone
2-Pyrrolidone, 1-methyl-
1-Methylazacyclopentane-2-one
1-Methylpyrrolidone
N-Methylpyrrolidone-(2)
N-Methylpyrrolid-2-one
Methylpyrrolidone
1-Methylazacyclopentan-2-one
Agsolex 1
N 0131
N-Methyl-gamma-butyrolactam
Micropure ultra
NSC 4594
NMP
N-METHYLPYRROLIDONE
1-METHYL-2-PYRROLIDINONE
1-methyl-pyrrolidin-2-one
1-METHYL-2-PYRROLIDONE
N-METHYL-2-PYRROLIDINONE
1-Methylpyrrolidin-2-one
N-METHYLPYRROLIDINON
Methylpyrrolidone
N-Methylpyrrolidon

DESCRIPTION:
N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
N-Methyl-2-pyrrolidone is a colorless liquid, although impure samples can appear yellow.
N-Methyl-2-pyrrolidone is miscible with water and with most common organic solvents.

CAS Number: 872-50-4
EINECS: No. 212-828-1

N-Methyl-2-pyrrolidone also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-Methyl-2-pyrrolidone is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).

N-Methyl-2-pyrrolidone is a polar solvent with outstanding characteristics.
N-Methyl-2-pyrrolidone has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.

N-Methyl-2-pyrrolidone is a 5-member-ring compound containing nitrogen.
N-Methyl-2-pyrrolidone has a wide range of uses due to the following excellent characteristics.

N-Methyl-2-pyrrolidone is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).
Organic and inorganic substances are highly soluble in it.
N-Methyl-2-pyrrolidone mixes with water in all proportions.

N-Methyl-2-pyrrolidone has a high flash point compared to similar solvents.
The boiling point is high, the freezing point is low, and handling is easy.
N-Methyl-2-pyrrolidone is chemically and thermally stable, and not corrosive.

N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid.
NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.
N-Methyl-2-Pyrrolidone is used as a solvent for engineering polymers and coating resins.

Additionally, the polar nature and the low surface tension of N-Methyl-2-Pyrrolidone makes it an excellent cleaning medium and paint stripping solvent.
N-Methyl-2-Pyrrolidone is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in:

Petrochemical processing:
N-Methyl-2-Pyrrolidone is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction, lube oil purification.
As illustration for the strong selectivity of N-Methyl-2-Pyrrolidone towards acetylene, the table below shows the solubility of acetylene in various solvents.




PREPARATION OF N-METHYL-2-PYRROLIDONE:
NMP is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis. About 200,000 to 250,000 tons are produced annually.

APPLICATIONS OF N-METHYL-2-PYRROLIDONE:
NMP is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-Methyl-2-pyrrolidone is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.
Its good solvency properties have led to NMP's use to dissolve a wide range of polymers.

Specifically, it is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-Methyl-2-pyrrolidone is also used as a solvent in the commercial preparation of polyphenylene sulfide.
In the pharmaceutical industry, N-methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes.

N-Methyl-2-pyrrolidone is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because NMP has a unique ability to dissolve polyvinylidene fluoride binder.
Due to NMP's toxicity and high boiling point, there is much effort to replace it in battery manufacturing with other solvent(s), like water.


BIOLOGICAL ASPECTS OF N-METHYL-2-PYRROLIDONE:
In rats, NMP is absorbed rapidly after inhalation, oral, and dermal administration, distributed throughout the organism, and eliminated mainly by hydroxylation to polar compounds, which are excreted via urine.
About 80% of the administered dose is excreted as NMP and NMP metabolites within 24 hours.
A probably dose dependent yellow coloration of the urine in rodents is observed.

The major metabolite is 5-hydroxy-N-methyl-2-pyrrolidone.
Studies in humans show comparable results.
Dermal penetration through human skin has been shown to be very rapid. NMP is rapidly biotransformed by hydroxylation to 5-hydroxy-N-methyl-2-pyrrolidone, which is further oxidized to N-methylsuccinimide; this intermediate is further hydroxylated to 2-hydroxy-N-methylsuccinimide.
These metabolites are all colourless.

The excreted amounts of NMP metabolites in the urine after inhalation or oral intake represented about 100% and 65% of the administered doses, respectively.
NMP has a low potential for skin irritation and a moderate potential for eye irritation in rabbits.
Repeated daily doses of 450 mg/kg body weight administered to the skin caused painful and severe haemorrhage and eschar formation in rabbits.

These adverse effects have not been seen in workers occupationally exposed to pure NMP, but they have been observed after dermal exposure to NMP used in cleaning processes.
No sensitization potential has been observed


APPLICATIONS OF N-METHYL-2-PYRROLIDONE:
N-methyl-2-pyrrolidone is used to produce fine chemicals from mass-produced chemicals.
N-methyl-2-pyrrolidone applications in the electronics field have expanded in recent years.
NMP's high polarity and high solvency power along with our high purity, high-grade production technology enable the high performance needed in this field.
NMP can dissolve organic and inorganic compounds equally well or better than chlorofluorocarbon solvents.

Therefore NMP is used in various industrial fields as a cleaning or release agent.
NMP is replacing 1,1,1-trichloroethane in metal cleaning applications due to the world-wide environmental pollution problems associated with chlorinated solvents.

1) Electronics:
• Wax, flux removal
• Burr removal
• Electronic parts cleaning
• Semiconductor parts cleaning
• Solvent for lithium battery manufacturing
• Semiconductor photo-resist thinner
• Color filter photo-resist thinner

2) Automotive:
• Mold cleaning
• Metal (parts) cleaning

3) Chemical:
• Extract agent (acetylene, BTX, butadiene)
• Synthetic resin surface coating solvent
• Reaction solvents (PPS, polyimide, etc.)
• Equipment washing

4) Optical:
• Plastic lens manufacturing equipment cleaning

5) Pharmaceutical and Agricultural Chemicals:
• Water-soluble solvent
• Cleaning
• Extraction


SAFETY INFORMATION ABOUT N-METHYL-2-PYRROLIDONE (NMP):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product


CHEMICAL AND PHYSICAL PROPERTIES OF N-METHYL-2-PYRROLIDONE:
Chemical formula C5H9NO
Molar mass 99.133 g•mol−1
Density 1.028 g/cm3
Melting point −24 °C (−11 °F; 249 K)
Boiling point 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water Soluble
Solubility in Ethanol, acetone, diethylether, ethyl acetate, chloroform, benzene Soluble
log P −0.40
Common Names G N-Methyl-2-Pyrrolidone,
1-Methyl-2-Pyrrolidone,
1-Methyl-Pyrrolidine-2-one,
N-Methyl-2-Pyrrolidinone
Structure NMP
CAS　No. 872-50-4
Japan Chemical Mfg. Reg. 5-113
Japan, Fire Services Law Hazardous material Class 4 Petroleums No.3 water-soluble Hazardous Rank III
Molecular Weight 99.14
Appearance Clear colorless liquid
Odor Faint amine smell
Specific Gravity (25/4℃) 1.027
Viscosity(mPa･s) 1.89（25℃）
Boiling Point (℃) 202
Freezing Point (℃) -23
Vapor specific gravity 3.4
Flash Point (℃) 99 (open cup)
Autoignition Temperature (℃) 252
Hue (APHA) <50
Specific Gravity (20/4℃) 1.027～1.030
Purity (%) >99.0
Moisture (%) <0.1
Refractive index (ND25 ℃) 1.465～1.470
Distillation test
(℃) initial boiling point >198
Distillation test
dry point (℃) <208
Distillation test
all distillate volume (vol%) >95
CAS number 872-50-4
EC index number 606-021-00-7
EC number 212-828-1
Hill Formula C₅H₉NO
Molar Mass 99.13 g/mol
HS Code 2933 79 90
Boiling point 202 °C (1013 hPa)
Density 1.03 g/cm3 (25 °C)
Explosion limit 1.3 - 9.5 %(V)
Flash point 91 °C
Ignition temperature 245 °C
Melting Point -24.2 °C
pH value 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure 0.32 hPa (20 °C)
Solubility 1000 g/l
Purity (GC) ≥ 99.5 %
Identity (IR) conforms
Color ≤ 10 Hazen
Density (d 20 °C/ 4 °C) 1.031 - 1.033
Refractive index (n 20/D) 1.4680 - 1.4730
Acidity ≤ 0.0002 meq/g
Alkalinity ≤ 0.003 meq/g
Water ≤ 0.10 %
Appearance (Clarity) Clear
Appearance (Colour) Colourless
Appearance (Form) Liquid
Assay (GC) min. 99.5%
Density (g/ml) @ 20°C 1.029-1.033
Refractive Index (20°C) 1.470-1.472
Boiling Range 202-204°C
Water (KF) max. 0.1%

N-Methyl-2-pyrrolidone (NMP), also known simply as NMP, is a solvent and chemical intermediate with the molecular formula C5H9NO.
N-Methyl-2-pyrrolidone (NMP) is a colorless to slightly yellow liquid with a faint amine-like odor.
N-Methyl-2-pyrrolidone (NMP) is widely used in various industries due to its excellent solvency properties and versatile chemical reactivity.

CAS Number: 872-50-4
EC Number: 212-828-1

NMP, N-Methylpyrrolidone, 1-Methyl-2-pyrrolidinone, N-Methyl-2-pyrrolidinone, N-Methylpyrrolidinone, 1-Methylpyrrolidin-2-one, 1-Methyl-2-pyrrolidone, Methylpyrrolidinone, Methylpyrrolidone, Pyrrolidin-2-one, Methyl-pyrrolidinone, 1-Methylpyrrolidone, Methyl-pyrrolidone, Pyrrolidinone, N-Methylpyrrolidone, N-Methyl-pyrrolidone, Methylpyrrolidone, N-Methyl-2-pyrrolidone, N-Methyl-pyrrolidone, Pyrrolidone, 1-Methylpyrrolidone



APPLICATIONS


N-Methyl-2-pyrrolidone (NMP) is widely used as a solvent in various industrial processes.
N-Methyl-2-pyrrolidone (NMP) is commonly employed in the production of paints, coatings, and varnishes.
N-Methyl-2-pyrrolidone (NMP) serves as a solvent for resins, polymers, and adhesives, aiding in their formulation and application.

In the electronics industry, NMP is used for cleaning and degreasing electronic components and circuit boards.
N-Methyl-2-pyrrolidone (NMP) is an effective solvent for removing solder flux residues and other contaminants from electronic assemblies.

N-Methyl-2-pyrrolidone (NMP) is utilized in the pharmaceutical industry for drug delivery systems and formulation of pharmaceutical products.
N-Methyl-2-pyrrolidone (NMP) helps solubilize poorly soluble drugs and enhance their bioavailability in oral and topical formulations.

N-Methyl-2-pyrrolidone (NMP) is employed as a solvent in the production of agrochemicals such as pesticides and herbicides.
N-Methyl-2-pyrrolidone (NMP) aids in the formulation of agricultural products and enhances their efficacy and stability.

In the textile industry, NMP is used as a solvent for dyeing and printing processes.
N-Methyl-2-pyrrolidone (NMP) helps dissolve dyes and pigments and facilitates their penetration into fibers for uniform coloration.
N-Methyl-2-pyrrolidone (NMP) is utilized in the manufacture of synthetic fibers and films, contributing to their processing and quality.

N-Methyl-2-pyrrolidone (NMP) serves as a reaction medium in organic synthesis, enabling various chemical transformations.
N-Methyl-2-pyrrolidone (NMP) is employed in the production of specialty chemicals, flavors, and fragrances.

It is used in the formulation of cleaning agents and degreasers for industrial and household applications.
N-Methyl-2-pyrrolidone (NMP) is utilized as a solvent in the production of lithium-ion batteries for electrode coatings and electrolytes.
N-Methyl-2-pyrrolidone (NMP) helps dissolve lithium salts and conductive additives, improving battery performance and cycle life.

N-Methyl-2-pyrrolidone (NMP) is used in the formulation of personal care products such as cosmetics, lotions, and skincare products.
N-Methyl-2-pyrrolidone (NMP) aids in solubilizing active ingredients and enhancing product stability and texture.

In the automotive industry, NMP is utilized in the formulation of paints, coatings, and sealants for vehicle assembly.
N-Methyl-2-pyrrolidone (NMP) helps dissolve and disperse pigments and additives, ensuring uniform coverage and protection.

N-Methyl-2-pyrrolidone (NMP) is employed in the production of membranes for separation and purification processes.
N-Methyl-2-pyrrolidone (NMP) serves as a solvent for membrane casting and helps control membrane morphology and performance.

N-Methyl-2-pyrrolidone (NMP) is used in the manufacture of specialty films and laminates for packaging and industrial applications.
Overall, N-Methyl-2-pyrrolidone (NMP) finds diverse applications across industries, owing to its excellent solvency properties and chemical versatility.

N-Methyl-2-pyrrolidone (NMP) is utilized in the formulation of inkjet inks for digital printing applications.
N-Methyl-2-pyrrolidone (NMP) helps dissolve colorants and additives, resulting in high-quality prints with excellent color reproduction.
N-Methyl-2-pyrrolidone (NMP) is used as a solvent in the production of carbon fibers and composite materials.

N-Methyl-2-pyrrolidone (NMP) aids in the dispersion of carbon precursors and improves the quality and mechanical properties of the final products.
In the pharmaceutical industry, NMP is employed as a solvent for extraction and purification of active pharmaceutical ingredients (APIs).

N-Methyl-2-pyrrolidone (NMP) facilitates the isolation of compounds from natural sources and synthetic intermediates.
N-Methyl-2-pyrrolidone (NMP) is utilized in the formulation of industrial and household cleaning products such as degreasers and surface cleaners.
N-Methyl-2-pyrrolidone (NMP) effectively dissolves oils, greases, and stubborn residues, making it suitable for heavy-duty cleaning applications.

N-Methyl-2-pyrrolidone (NMP) is used as a carrier solvent in the formulation of agricultural pesticides and insecticides.
N-Methyl-2-pyrrolidone (NMP) helps disperse and stabilize active ingredients and enhances their penetration into plant tissues.

In the polymer industry, NMP is employed as a solvent for polymerization reactions and polymer processing.
N-Methyl-2-pyrrolidone (NMP) aids in the dissolution of polymer resins and additives, facilitating the production of high-performance materials.
N-Methyl-2-pyrrolidone (NMP) is utilized in the production of pharmaceutical excipients such as binders and solubilizers.

N-Methyl-2-pyrrolidone (NMP) helps improve the flow properties and compressibility of tablet formulations.
N-Methyl-2-pyrrolidone (NMP) is employed in the synthesis of specialty chemicals and intermediates for organic synthesis.

N-Methyl-2-pyrrolidone (NMP) serves as a versatile reagent in various chemical transformations, including amide bond formation and cyclization reactions.
N-Methyl-2-pyrrolidone (NMP) is used in the formulation of adhesive removers and paint strippers for industrial and consumer applications.

N-Methyl-2-pyrrolidone (NMP) helps dissolve and remove cured adhesives, paints, and coatings from substrates.
N-Methyl-2-pyrrolidone (NMP) is employed in the production of lubricants and metalworking fluids for industrial machining processes.
It serves as a carrier solvent for additives and lubricant components, improving machining performance and surface finish.

N-Methyl-2-pyrrolidone (NMP) is used in the formulation of sealants and caulks for construction and building applications.
N-Methyl-2-pyrrolidone (NMP) helps achieve proper rheology and adhesion properties in sealant formulations.
N-Methyl-2-pyrrolidone (NMP) is employed in the production of polymer membranes for gas separation and purification.

N-Methyl-2-pyrrolidone (NMP) serves as a solvent for membrane casting and helps control membrane morphology and pore size distribution.
Overall, N-Methyl-2-pyrrolidone (NMP) continues to find diverse applications across industries, demonstrating its versatility and utility as a solvent and chemical intermediate.



DESCRIPTION


N-Methyl-2-pyrrolidone (NMP), also known simply as NMP, is a solvent and chemical intermediate with the molecular formula C5H9NO.
N-Methyl-2-pyrrolidone (NMP) is a colorless to slightly yellow liquid with a faint amine-like odor.
N-Methyl-2-pyrrolidone (NMP) is widely used in various industries due to its excellent solvency properties and versatile chemical reactivity.

As a solvent, NMP is valued for its ability to dissolve a wide range of substances, including polymers, resins, oils, and pharmaceutical compounds.
N-Methyl-2-pyrrolidone (NMP) is commonly utilized in applications such as paint and coating formulations, cleaning agents, electronic materials, pharmaceuticals, and agrochemicals.

N-Methyl-2-pyrrolidone (NMP) is also employed as a reaction medium and chemical intermediate in organic synthesis.
N-Methyl-2-pyrrolidone (NMP) participates in various chemical reactions, including condensation, alkylation, and oxidation reactions, to produce a variety of organic compounds.
Additionally, NMP is used as a carrier solvent in chemical processes such as extraction and separation.

Despite its utility, NMP is known to have some health and environmental concerns.
N-Methyl-2-pyrrolidone (NMP) may cause skin and eye irritation upon contact and can be absorbed through the skin, potentially leading to systemic toxicity.

N-Methyl-2-pyrrolidone (NMP) is also classified as a reproductive toxicant and may have adverse effects on fertility and development.
Due to these risks, proper handling precautions, such as using personal protective equipment and implementing adequate ventilation, are necessary when working with NMP.

N-Methyl-2-pyrrolidone (NMP) is a colorless to slightly yellow liquid.
N-Methyl-2-pyrrolidone (NMP) has a molecular formula of C5H9NO.
The chemical structure of NMP consists of a pyrrolidone ring with a methyl group attached.

N-Methyl-2-pyrrolidone (NMP) has a faint amine-like odor.
N-Methyl-2-pyrrolidone (NMP) is soluble in water and many organic solvents.

N-Methyl-2-pyrrolidone (NMP) exhibits excellent solvency properties, making it a versatile solvent in various applications.
The boiling point of NMP is approximately 202°C, while its melting point is around -24°C.

N-Methyl-2-pyrrolidone (NMP) has a density of approximately 1.03 g/cm³ at 20°C.
N-Methyl-2-pyrrolidone (NMP) is hygroscopic, meaning it can absorb moisture from the atmosphere.

N-Methyl-2-pyrrolidone (NMP) is stable under normal conditions but may react with strong oxidizing agents.
N-Methyl-2-pyrrolidone (NMP) is commonly used in the production of paints, coatings, and adhesives.
N-Methyl-2-pyrrolidone (NMP) is also utilized as a solvent in the electronics industry for cleaning circuit boards and semiconductor devices.

N-Methyl-2-pyrrolidone (NMP) serves as a reaction medium in organic synthesis due to its ability to dissolve a wide range of organic compounds.
N-Methyl-2-pyrrolidone (NMP) is employed in pharmaceutical formulations for drug delivery and solubilization of active ingredients.

N-Methyl-2-pyrrolidone (NMP) is used in the production of polymers and resins, contributing to their processing and performance properties.
N-Methyl-2-pyrrolidone (NMP) can be found in consumer products such as cleaning agents and personal care products.
N-Methyl-2-pyrrolidone (NMP) is known for its high boiling point, which allows for efficient solvent recovery in industrial processes.

N-Methyl-2-pyrrolidone (NMP) is classified as a polar aprotic solvent, meaning it does not donate hydrogen ions but can solvate metal ions.
N-Methyl-2-pyrrolidone (NMP) is compatible with a variety of materials including plastics, rubbers, and metals.

It is considered a hazardous chemical and should be handled with appropriate safety precautions.
N-Methyl-2-pyrrolidone (NMP) has a relatively low vapor pressure, reducing the risk of inhalation exposure.

The viscosity of NMP can vary depending on temperature and concentration.
N-Methyl-2-pyrrolidone (NMP) is a versatile chemical with applications in diverse industries including pharmaceuticals, textiles, and coatings.

NMP is subject to regulatory controls due to its potential health and environmental impacts.
Overall, N-Methyl-2-pyrrolidone (NMP) is a valuable solvent and chemical intermediate with a wide range of industrial applications.



PROPERTIES


Chemical Formula: C5H9NO
Molecular Weight: Approximately 99.13 grams per mole
Physical State: Liquid
Color: Colorless to slightly yellow
Odor: Faint amine-like odor
Taste: Not applicable
Solubility in Water: Miscible
Solubility in Organic Solvents: Miscible with most organic solvents
Melting Point: Approximately -24°C
Boiling Point: Approximately 202°C
Density: Approximately 1.028 g/cm³ at 20°C
pH: Neutral
Viscosity: Relatively high viscosity
Refractive Index: Approximately 1.467 at 20°C
Flash Point: Approximately 95°C (closed cup)
Autoignition Temperature: Approximately 245°C
Vapor Pressure: Approximately 0.1 mmHg at 20°C
Heat of Combustion: Approximately -3289 kJ/mol
Heat of Vaporization: Approximately 47.9 kJ/mol
Specific Heat Capacity: Approximately 2.01 J/g°C
Surface Tension: Approximately 37.2 mN/m at 20°C
Dielectric Constant: Approximately 32.4 at 20°C
Hygroscopicity: Moderate
Flammability: Non-flammable under normal conditions
Toxicity: Considered toxic if ingested, inhaled, or absorbed through the skin



FIRST AID


Inhalation:

If inhaled, immediately remove the affected person to fresh air.
Assist the person to a well-ventilated area and ensure they are in a comfortable position.
If breathing is difficult, administer oxygen if trained to do so.
Seek medical attention promptly.
Keep the affected person under observation until medical help arrives.


Skin Contact:

Remove contaminated clothing and shoes immediately.
Wash the affected area with plenty of soap and water for at least 15 minutes.
Rinse skin thoroughly to remove any traces of NMP.
If irritation, redness, or rash develops, seek medical advice.
Apply a soothing moisturizer or barrier cream to the affected area to help alleviate discomfort.
Seek medical attention if symptoms persist or worsen.


Eye Contact:

Flush eyes with lukewarm water, keeping eyelids open, for at least 15 minutes.
Remove contact lenses if present and easily removable.
Seek immediate medical attention if irritation, pain, or redness persists.
Protect the unaffected eye to prevent contamination.
Provide relevant information about the chemical to medical personnel.


Ingestion:

Rinse mouth with water and drink plenty of water to dilute the substance.
Do not induce vomiting unless instructed to do so by medical personnel.
Seek medical attention immediately and provide information on the ingested substance.
Do not give anything by mouth to an unconscious person.


General Advice:

Keep affected person calm and reassure them.
If seeking medical attention, provide the Safety Data Sheet (SDS) or product label information to healthcare providers.
If the substance has entered the respiratory tract, monitor for signs of respiratory distress and administer CPR if necessary.
Do not administer any medications unless directed by medical personnel.
If exposed to large quantities or experiencing severe symptoms, seek emergency medical assistance immediately.
Be prepared to provide information on the specific product, concentration, and duration of exposure when seeking medical advice.
If transporting an affected individual to a medical facility, ensure proper ventilation and monitor their condition closely.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear suitable protective clothing, including gloves, safety glasses, and a lab coat, when handling NMP to prevent skin contact and eye irritation.
Use respiratory protection, such as a dust mask or respirator, if handling in powdered form or in poorly ventilated areas to prevent inhalation of dust particles.

Ventilation:
Handle NMP in a well-ventilated area or under a fume hood to minimize exposure to airborne particles and vapors.
Ensure adequate ventilation in storage areas to prevent the accumulation of vapors and maintain air quality.

Avoidance of Contamination:
Prevent contamination of NMP by keeping containers tightly closed when not in use.
Do not allow the substance to come into contact with incompatible materials, such as strong oxidizing agents or bases, to avoid hazardous reactions.

Safe Handling Practices:
Avoid generating dust or aerosols when handling NMP.
Use appropriate handling tools, such as scoops or spatulas, to minimize skin contact and prevent spills.
Do not eat, drink, or smoke while handling NMP to prevent accidental ingestion.

Emergency Procedures:
Familiarize yourself and other personnel with emergency procedures in case of spills, leaks, or exposure incidents.
Have appropriate spill control measures, absorbent materials, and personal protective equipment readily available.


Storage:

Storage Conditions:
Store NMP in a cool, dry, well-ventilated area away from sources of heat, moisture, and direct sunlight.
Keep containers tightly closed when not in use to prevent contamination and moisture absorption.

Temperature and Humidity:
Maintain storage temperature within the recommended range (typically room temperature) to ensure stability and minimize degradation.
Avoid exposure to extreme temperatures or fluctuations, as this may affect the quality and shelf life of the product.

Compatibility:
Store NMP away from incompatible materials, such as strong oxidizing agents, alkalis, and reducing agents, to prevent hazardous reactions.
Segregate NMP from other chemicals to avoid cross-contamination and potential hazards.

Labeling and Identification:
Clearly label storage containers with the product name, hazard warnings, handling instructions, and date of receipt.
Ensure proper identification and labeling of NMP to prevent confusion and facilitate safe handling and storage.

Security Measures:
Restrict access to storage areas containing NMP to authorized personnel only.
Implement appropriate security measures, such as locked cabinets or storage rooms, to prevent unauthorized access or tampering.

Spill Containment and Cleanup:
Have spill containment kits, absorbent materials, and personal protective equipment readily available for spill cleanup.
Follow established spill cleanup procedures and disposal guidelines to minimize environmental impact and ensure safety.

Regulatory Compliance:
Store and handle NMP in compliance with local regulations, codes, and guidelines governing the storage and handling of hazardous substances.
Maintain accurate records of storage conditions, inventory levels, and handling procedures for regulatory compliance and safety auditing purposes.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a versatile, polyfunctional molecule that combines thecharacteristics of amines and alcohols.
N-Methyldiethanolamine has a relatively low heat of reaction with hydrogen sulfide and carbon dioxide, which allows for lower reboiler duties, thus lower operating costs.

CAS Number: 105-59-9
EC number: 203-312-7
Molecular Formula: C5H13NO2
Molecular weight: 119.1622

N-Methyldiethanolamine is a dihydroxy functional tertiary amine.
N-Methyldiethanolamine is a versatile intermediate with a variety of applications.
N-Methyldiethanolamine's popularity as a solvent for gas treating stems from several advantages N-Methyldiethanolamine has when compared to other alkanolamines.

One of the advantages of N-Methyldiethanolamine is a low vapor pressure, which allows for high amine compositions without appreciable losses through the absorber and regenerator.
N-Methyldiethanolamine is also resistant to thermal and chemical degradation and is largely immiscible with hydrocarbons.
N-Methyldiethanolamine is a common base note in perfumes to allow the fragrance to last.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, ethanol and benzene.

N-Methyldiethanolamine has a relatively low heat of reaction with hydrogen sulfide and carbon dioxide, which allows for lower reboiler duties, thus lower operating costs.
N-Methyldiethanolamine's defining characteristic when compared to these other amines is N-Methyldiethanolamine's ability to preferentially remove H2S (and strip CO2) from sour gas streams.

N-Methyldiethanolamine is a colorless liquid.
N-Methyldiethanolamine is an alkanolamine.
N-Methyldiethanolamine is a commonly traded chemical that is subject to international controls, specifically under Schedule 3 of the Chemical Weapons Convention (CWC).

N-Methyldiethanolamine is a precursor to mechlorethamine (Bis(2-chloroethyl)methylamine), a nitrogen mustard chemical warfare agent developed for use as a vesicant or blister agent, similar to sulfur mustards.
The surface tension of N-Methyldiethanolamine in methanol, or in methanol aqueous solutions as a solvent, was measured at temperatures from 293.15 to 323.15 K.

On-site More selective for H2S over CO2 versus other amines, N-Methyldiethanolamine is commonly N-Methyldiethanolamine in amine units.
Miscible with water, low molecular weight alcohols, esters, acetone, benzene and chlorinated hydrocarbons; not miscible with diethylether or aliphatic hydrocarbons.
N-Methyldiethanolamine is a clear, colorless or pale yellow liquid with an ammonia odour.

N-Methyldiethanolamine is miscible with water, alcohol and benzene.
N-Methyldiethanolamine is also known as a MDEA or N-Methyl diethanolamine and has the formula CH3N (C2H4OH)2.

N-Methyldiethanolamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
N-Methyldiethanolamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

N-Methyldiethanolamine is a tertiary amine.
N-Methyldiethanolamine should not be confused with similarly named MEA or DEA and the commercial drug MDEA.

N-Methyldiethanolamine (MDEA) is a tertiary amine.
N-Methyldiethanolamine is a versatile, polyfunctional molecule that combines thecharacteristics of amines and alcohols.
N-Methyldiethanolamine is capable of undergoing reactions typical of both alcohols and amines, forming Quaternary amine salts, soaps, and esters.

N-Methyldiethanolamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Release to the environment of N-Methyldiethanolamine is likely to occur from outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

N-Methyldiethanolamine can be found in products with material based on plastic (e.g. food packaging and storage, toys, mobile phones).
N-Methyldiethanolamine is an amino alcohol, organic compound.

N-Methyldiethanolamine is obtained in industry through the interaction of ethylene oxide and methylamine.
Global N-Methyldiethanolamine demand exceeds 200,000 tonnes per year.

The rapid development in the production of liquefied natural gas determines the growth in the demand for N-Methyldiethanolamine based absorbents.
N-Methyldiethanolamine, also known as methyl diethanolamine, or MDEA, is an organic compound with the formula CH3N(C2H4OH)2.

N-Methyldiethanolamine is a colorless liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, alcohol, and benzene.

A combination of N-Methyldiethanolamine and piperazine is used.
The N-Methyldiethanolamine solution and the monoethanolamine solution are continuously regenerated through heat application.

A method for recycling liquid absorbent for acid vapor is comprising N-Methyldiethanolamine and lower alkylpiperazin.
N-Methyldiethanolamine (MDEA) is a colorless to yellow viscous liquid with an ammonia-like odor.

N-Methyldiethanolamine is completely soluble in water.
N-N-Methyldiethanolamine is an alkyl alkanolamine.
N-Methyldiethanolamine combines the chemical characteristics of both amines and alcohols so that N-Methyldiethanolamine is capable of undergoing reactions typical of both alcohols and amines: forming quaternary amine salts, soaps, and esters.

N-Methyldiethanolamine is produced by the reaction between ethylene oxide and methylamine.
N-Methyldiethanolamine is an aminoalcohol.

N-Methyldiethanolamine may react with oxidizing materials.
N-Methyldiethanolamine is readily biodegradable.

N-Methyldiethanolamine can react with halogenated organics, resulting in temperature and/or pressure increases.
N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH₃N(C₂H₄OH)₂.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine is miscible with water, alcohol, and benzene.
N-Methyldiethanolamine is an excellent solution for selectivity between H2S and CO2 removal.
N-Methyldiethanolamine can be used in higher concentrations up to 55wt%.

N-Methyldiethanolamine is a colorless, transparent liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, ethanol and benzene.

The addition of an activator, or more specifically piperazine (PZ) to an aqueous N-Methyldiethanolamine solution has found widespread application in the bulk removal of carbon dioxide.
N-Methyldiethanolamine is produced using methylamine and ethylene oxide ethoxylation.

N-Methyldiethanolamine reacts easily with hydrogen sulphide and carbon dioxide as a diluted solution, in order to eliminate hydrogen sulphide and carbon dioxide formed during the processing stage from natural gas and crude oil.
N-Methyldiethanolamine can be combined with water, benzene and alcohol.
N-Methyldiethanolamine is a clear, Colorless or Pale Yellow liquid with Ammonical Odor.

N-Methyldiethanolamine is miscible with water, alcohol and benzene.
N-Methyldiethanolamine is also known as a MDEA or N-Methyl Diethanolamine.

N-Methyldiethanolamine is more efficient absorber then MEA & DEA for sulphur contains impurity and acid gases found in natural gas processing.
N-Methyldiethanolamine is versatile bifunctional molecules compound that combines the characteristic of Amine and hydroxyl group.

During the reaction N-Methyldiethanolamine behaves like Alcohol and Amine Group but Amine group usually exhibits the greater activities.
N-Methyldiethanolamine can be modified with the help of some additives.
One of the most, popular and practical formulated amines is N-Methyldiethanolamine activated by piperazine (a-MDEA) which developed based on BASF company license in the early 1970s and the first commercial unit for sweetening of natural gases installed in 1982.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, ethanol and benzene.

N-Methyldiethanolamine's defining characteristic when compared to these other amines is N-Methyldiethanolamine's ability to preferentially remove H2S (and strip CO2) from sour gas streams.
N-Methyldiethanolamine's popularity as a solvent for gas treating stems from several advantages N-Methyldiethanolamine has when compared to other alkanolamines.

N-Methyldiethanolamine is also resistant to thermal and chemical degradation and is largely immiscible with hydrocarbons.
N-Methyldiethanolamine is first esterified with 2 molecules of fatty acid (mostly C12-acid or stearic acid).

N-Methyldiethanolamine is a clear hygroscopic liquid with an amine-like odor.
The freshly distilled N-Methyldiethanolamine is colorless, but prolonged storage may cause a yellowish discoloration.

N-Methyldiethanolamine (MDEA) a clear, water-white, hygroscopic liquid with an ammoniacal odor.
Bulk carbon dioxide removal can be realized with N-Methyldiethanolamine when the CO2:H2S ratio ranges from 100 to 1,000.

N-Methyldiethanolamine, or methyl diethanolamine, or MDEA, is organic synthesis.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine is miscible with water, alcohol, and benzene.
N-Methyldiethanolamine is utilized for amine gas treating, for gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical manufacturing and production.
N-Methyldiethanolamine molecule consists of 13 Hydrogen atom(s), 5 Carbon atom(s), 1 Nitrogen atom(s) and 2 Oxygen atom(s) - a total of 21 atom(s).

N-Methyldiethanolamine, also known as methyl diethanolamine, or MDEA, is an organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine is miscible with water, alcohol, and benzene.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH 3N(C 2H 4OH) 2.
N-Methyldiethanolamine (MDEA) is a colorless liquid.
The pKa of N-Methyldiethanolamine is 8.52, indicating that N-Methyldiethanolamine will partially exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts.

N-Methyldiethanolamine is an organic compound and the formula of N-Methyldiethanolamine is CH3N (C2H4OH)2.
N-Methyldiethanolamine can be mixed with alcohol, water and benzene.

The advantages of N-Methyldiethanolamine as compared to other amines is N-Methyldiethanolamine had the ability to remove H2S and CO2 from the sour gas streams.
N-Methyldiethanolamine has several advantages as compared to other alkanolamines.

N-Methyldiethanolamine has a low heat of reaction with the carbon dioxide and hydrogen sulphide and which allows lower reboiler duties due to the lower operating costs.
Purest N-Methyldiethanolamine can used to remove the H2S and CO2 during the gas treating process.
The N-Methyldiethanolamine is commonly used in refineries, petrochemical plants, natural gas processing plants and other industries.

Uses of N-Methyldiethanolamine:
N-Methyldiethanolamine is used as an intermediate, to absorb acidic gases, as catalyst for polyurethane foams, and pH control agent.
N-Methyldiethanolamine is used in chemical syntheses (i.e. pharmaceuticals and cationic surfactants), as a cleaning-washing agent, pH regulator (coating manufacture), and solvent (removal of acid gases in oil refineries).
N-Methyldiethanolamine is used to make fine and large scale chemicals, as a catalyst in polymerization reactions, laboratory reagent, additive in coatings and concrete-cement, in gas treatment, and lubricants and metalworking fluids.

Consumer Uses:
N-Methyldiethanolamine is used in the following products: washing & cleaning products.
Other release to the environment of N-Methyldiethanolamine is likely to occur from: indoor use as processing aid.

Other Consumer Uses:
Not Known or Reasonably Ascertainable
Paint additives and coating additives not described by other categories
Processing aids, specific to petroleum production

Widespread uses by professional workers:
N-Methyldiethanolamine is used in the following products: coating products, lubricants and greases, metal working fluids, polymers, laboratory chemicals, pH regulators and water treatment products and washing & cleaning products.
N-Methyldiethanolamine is used in the following areas: building & construction work and scientific research and development.

N-Methyldiethanolamine is used for the manufacture of: and plastic products.
Other release to the environment of N-Methyldiethanolamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industrial sites:
N-Methyldiethanolamine is used in the following products: laboratory chemicals, coating products, pH regulators and water treatment products, lubricants and greases, metal working fluids and polymers.
N-Methyldiethanolamine is used in the following areas: building & construction work and scientific research and development.

N-Methyldiethanolamine is used for the manufacture of: chemicals, and plastic products.
Release to the environment of N-Methyldiethanolamine can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release, in the production of articles and as processing aid.

Industry Uses:
Absorbent
Intermediate
Intermediates
Not Known or Reasonably Ascertainable
Paint additives and coating additives not described by other categories
Processing aids not otherwise specified
Processing aids, specific to petroleum production
Solvent
pH regulating agent

Industrial Processes with risk of exposure:
Metal Machining
Petroleum Production and Refining
Painting (Pigments, Binders, and Biocides)
Cement Producing

Applications of N-Methyldiethanolamine:
N-Methyldiethanolamine is used as a co-initiator for type II photoinitiator combinations.
As a neutralizing agent, N-Methyldiethanolamine increases resin solubility and improves solution stability by reducing pH drift.
N-Methyldiethanolamine aids pigment dispersion.

N-Methyldiethanolamine can be used as a chain extender during the synthesis of polyol-based polyurethane foams and elastomers.
N-Methyldiethanolamine is used as a co-initiator for type II photoinitiator combinations.

In metal working fluids, N-Methyldiethanolamine is used both as a pH buffer as well as an anticorrosion additive.
N-Methyldiethanolamine forms quat salts with fatty acids which then find application in fabric softener formulations.

Preventing the formation of bicine in operating N-Methyldiethanolamine solvents is accepted as the best way to control corrosion.
A tertiary amine, N-Methyldiethanolamine is widely used as a sweetening agent in chemical, oil refinery, syngas production and natural gas.

The BASF-formulated N-Methyldiethanolamine solvent achieves a high degree of COS removal and retains appreciable selectivity for H2S over CO2.
N-Methyldiethanolamine is a useful intermediate in the synthesis of numerous products, and has resulted in N-Methyldiethanolamine use in many diverse areas, including coatings, textile lubricants, polishes, detergents,pesticides, personal care products, and pharmaceuticals.

N-Methyldiethanolamine is an alkyl alkanolamine that is used in gas treatment applications and serves as an intermediate in the synthesis of numerous products.
N-Methyldiethanolamine is widely used as a sweating agent or decarbonizer in chemical, oil refinery, syngas production and natural gas.

Monitoring N-Methyldiethanolamine levels in rich and lean amine can help maintain appropriate corrosion protection, extending system lifetime and avoiding costly corrosion-induced shutdowns and failures.
N-Methyldiethanolamine is used as an intermediate, to absorb acidic gases, as catalyst for polyurethane foams, and pH control agent.
N-Methyldiethanolamine is used in chemical syntheses (i.e. pharmaceuticals and cationic surfactants), as a cleaning-washing agent, pH regulator (coating manufacture), and solvent (removal of acid gases in oil refineries).

N-Methyldiethanolamine is used to make fine and large scale chemicals, as a catalyst in polymerization reactions, laboratory reagent, additive in coatings and concrete-cement, in gas treatment, and lubricants and metalworking fluids.
Permitted for use as an inert ingredient in non-food pesticide products.
N-Methyldiethanolamine (MDEA) is a widely-used corrosion inhibitor that acts as a hydrogen sulfide scavenger in oil and gas processing.

N-Methyldiethanolamine has also been used as a chemotherapy agent in the treatment of Hodgkin lymphoma, leukaemia, and lung cancer.
N-Methyldiethanolamine is a reagent used for protection of boronic acids as N-methyl-O,O-diethanolamine esters.
N-Methyldiethanolamine is known by at least 93 different synonyms and has many commercial applications, including in the manufacture of construction and building materials, ink for inkjet printers, film forming, and as a component in fragrances.

Synthesis of aluminophosphate-based molecular sieves.
Preparation of N-methyl-N-R-N,N-bis(2-hydroxyethyl) ammonium bromides.

Preparation of cationic polyurethane dispersions.
N-Methyldiethanolamine is used in Urethanes, Paper Chemicals, Textile Softners, Pharmaceuticals, Gas scrubbing (CO2, H2S removal in natural, refining gas, ammonia hydrogen unit), Dyes and Polyurethane.

N-Methyldiethanolamine is used in the following products: coating products, lubricants and greases, metal working fluids, polymers and laboratory chemicals.
N-Methyldiethanolamine is used in the building & construction work.
N-Methyldiethanolamine is used for the manufacture of plastic products.

N-Methyldiethanolamine is used in the polymers.
N-Methyldiethanolamine is used in the laboratory chemicals, pH regulators and water treatment products, coating products, lubricants and greases, metal working fluids and polymers.

N-Methyldiethanolamine has an industrial use resulting in manufacture of another substance (use of intermediates).
N-Methyldiethanolamine is used for the manufacture of chemicals and textile, leather or fur.

N-Methyldiethanolamine is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
N-Methyldiethanolamine, as well as special sorbents based on N-Methyldiethanolamine (various grades of special modified MDEA), are widely used in amine treatment for the removal of acidic impurities from natural and process gases.
N-Methyldiethanolamine is used in the chemical industry and the production of synthetic detergents.

As a tertiary amine, N-Methyldiethanolamine is widely used as a sweetening agent in chemical plants, oil refineries, syngas, and natural gas production.
N-Methyldiethanolamine is used as an intermediate in the synthesis of numerous products.
N-Methyldiethanolamine's unique chemistry has resulted in N-Methyldiethanolamine use in diverse areas, including coatings, textile lubricants, polishes, detergents, pesticides, personal-care products, pharmaceuticals, urethane catalysts, and water-treatment chemicals.

N-Methyldiethanolamine is also used in absorption of acidic gases, catalyst for polyurethane foams, pH control agent.
N-Methyldiethanolamine is a reagent used for protection of boronic acids as N-methyl-O,O-diethanolamine esters.
N-Methyldiethanolamine is used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical industry.

N-Methyldiethanolamine is a tertiary amine and is widely used as a sweetening agent in chemical, oil refinery, syngas production and natural gas.
N-Methyldiethanolamine is used mainly in the construction industry.
N-Methyldiethanolamine is also used as an intermediate for agricultural chemicals, emulsifiers, textile auxiliaries, corrosion inhibitors, dyes, coatings, pharmaceuticals and also as a catalyst for polyurethane foam production.

N-Methyldiethanolamine is commonly used for the treatment of amine gas and for gas sweetening.
In the petrochemical industry, N-Methyldiethanolamine is generally used to treat amine gas, also known as gas sweeter or acid gas removal, to remove hydrogen sulphide and carbon dioxide from fuels.

N-Methyldiethanolamine is a common base note in perfumes to allow the fragrance to last.
N-Methyldiethanolamine is widely used as a sweetening agent in chemical, oil refinery, syngas production and natural gas.

N-Methyldiethanolamine is used in manufacturing of softener, soap emulsifying agent, Lubricants, Paraffin Emulsion and dyes.
In synthesis of analgesics and the intermediate product for some products.

Purifies the gases particularly natural gas for the bulk removable of Carbon Dioxide and also used as a scrubbing and extracting agent in Gas treatment.
Effective catalyst for urethane and epoxy resin coating system.

N-Methyldiethanolamine is used in lubricating oil, hydraulic fluids, corrosion inhibitor, refractory binder, surface active agent, solvent in water paint formula, Herbicides, Pesticides formulation and for PH control.
N-Methyldiethanolamine is widely used as a decarbonizer and Sweating agent in chemical, oil refinery, Gas synthesis, Natural gas & gas.

The use of tertiary N-Methyldiethanolamine (MDEA) as an absorbent for the CO2 removal from process gas streams has increased due to N-Methyldiethanolamine advantages over primary and secondary amines.
The various types of amines such as N-Methyldiethanolamine (MDEA) have been used for gas treating systems in a wide variety of applications.

The amino-alcohol functionality of N-Methyldiethanolamine makes N-Methyldiethanolamine a very useful precursor for fatty ester quaternaries (also called esterquats).
N-Methyldiethanolamine are commonly used as active substances in fabric softeners and are a good alternative to the TEA-esterquats (based on triethanolamine), in terms of both biodegradability and cost/performance.

N-Methyldiethanolamine can be used in the cationic modification of acrylic polymer dispersions.
In the production of silicone-based textile finishing agents, N-Methyldiethanolamine is used in combination with perfluoroalkyl polymers.
By reaction with epichlorohydrin and formic acid hydroxy functionalized quaternary ammonium compounds based on N-Methyldiethanolamine can be transformed into cationic polyurethanes, useful as paper sizing agents.

N-Methyldiethanolamine can be used as a precursor for pharmaceutical active substances.
N-Methyldiethanolamine is an alkanolamine used in tail gas treating and hydrogen sulfide enrichment units for selectively removing hydrogen sulfide from gas streams containing carbon dioxide.
N-Methyldiethanolamine is also used in natural gas plants for the bulk removal of carbon dioxide while producing a gas stream containing 0.25 grains hydrogen sulfide/100 scf.

Uses are urethane catalyst, textile softeners, pH control, and epoxy resin curing agents.
N-Methyldiethanolamine (N-methyl-diethanolamine), CH3N (C2H4OH)2, a chemical used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulphide and carbon dioxide from gases in the petrochemical industry.
N-Methyldiethanolamine (MDEA) is a tertiary amine commonly used to remove acid gases from gas streams.

N-Methyldiethanolamine (105-59-9) is a reagent used to protect boric acid as N-methyl-O,O-diethanolamine ester.
N-Methyldiethanolamine is used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical industry.
N-Methyldiethanolamine (MDEA) is a tertiary amine and commonly used for removal of acid gases from gas streams.

N-Methyldiethanolamine is used as an intermediate, in absorption of acidic gases, as a catalyst for polyurethane foams, and pH control agent.
N-Methyldiethanolamine tertiary amine most commonly used for sweetening syngas production, oil refinary, chemical, and natural gas.

Similarly like the compounds of N-Methyldiethanolamine the primary amine monoethanolamine (MEA) and the secondary amine diethanolamine (DEA) both can be used for amine gas treating.
N-Methyldiethanolamine also used to resistant the chemical and thermal degradation.
N-Methyldiethanolamine amine gas treating process most commonly used for petrochemical plants, refineries, natural gas processing plants and food & beverage industry.

One of the major application of N-Methyldiethanolamine is gas treating.
N-Methyldiethanolamine is mainly used as an active substance in fabric softeners and is a good alternative to TEA.
In the paints industry N-Methyldiethanolamine is utilized in combination with perfluoroalkyl acid polymers to produce silicone-based textile finishing agents.

Advantages of N-Methyldiethanolamine:
Selectivity to hydrogen sulphide.
Reduction of 30% in energy consumption.
Increased productivity.
Low corrosiveness.
No resin formation.
Reduction in circulating absorbent consumption.

Blends of N-Methyldiethanolamine:
N-Methyldiethanolamine is less reactive towards CO2, but has an equilibrium loading capacity approaching 1 mole CO2 per mole amine.
N-Methyldiethanolamine also requires less energy to regenerate.
To combine the advantages of N-Methyldiethanolamine and the smaller amines, N-Methyldiethanolamine is usually mixed with a catalytic promoter such as piperazine, PZ, or a fast reacting amine such as MEA to retain reactivity, but lower regeneration costs.

Activated N-Methyldiethanolamine or aMDEA uses piperazine as a catalyst to increase the speed of the reaction with CO2.
N-Methyldiethanolamine has been commercially successful.
Many tests have been done on the performance of N-Methyldiethanolamine/MEA or N-Methyldiethanolamine/piperazine mixtures compared to single amines.

CO2 production rates were higher than MEA for the same heat duty and total molar concentration when experiments were performed in the University of Regina pilot plant, which is a modeled after a natural gas plant.
There were also insignificant trace amounts of degradation products detected.
When the same control variables and tests were conducted at the Boundary Dam Power Station plant, the CO2 production rate for the mixed solvent was lower than MEA.

This was a result of the reduction in the capacity of the solvent to absorb CO2 after degradation.
Because the Boundary Dam plant is a coal-fired power plant, N-Methyldiethanolamine operates under harsher environments and produces an impure flue gas containing, fly ash, SO2, and NO2 that are fed into carbon capture.

Even with flue gas pretreatment, there is still enough to produce degradation products such as straight chain amines and sulfur compounds, which accumulate so N-Methyldiethanolamine is no longer possible to regenerate MEA and N-Methyldiethanolamine.
For these blends to be successful in reducing heat duty, their chemical stabilities must be maintained.

Degradation of N-Methyldiethanolamine:
Main oxidative degradation products of N-Methyldiethanolamine include monoethanol amine (MEA), methyl-aminoethanol (MAE), diethanolamine (DEA), amino acids bicine, glycine and hydroxyethyl sarcosine (HES), formyl amides of MAE and DEA, ammonia, and stable salts formate, glycolate, acetate, and oxalate.

In an industrial plan that utilizes N-Methyldiethanolamine, oxidative degradation is most likely to shift to the cross exchanger where temperatures are greater than 70 °C.
Higher temperatures and higher CO2 loading accelerate the rate of degradation, resulting in an increase of alkalinity loss as well as total formate production.

While N-Methyldiethanolamine is more resistant to degradation as a standalone compared to MEA, N-Methyldiethanolamine is preferentially degraded when in an N-Methyldiethanolamine/MEA blend.
Because of the formation of DEA and MAE, which could form nitroso-compounds or diethylnitrosamine and diethylnitraine, the blend could potentially have an adverse impact in terms of atmospheric admissions.

In the Boundary Dam plant, emissions increased when CO2 loading of lean amine increased for the blend and MEA.
Decreasing the lean loading increases the reboiler heat duty, which results in an obvious tradeoff between emissions and heat duty or energy costs.

Production of N-Methyldiethanolamine:
N-Methyldiethanolamine is produced by ethoxylation of methylamine using ethylene oxide:
CH3NH2 + 2 C2H4O → CH3N(C2H4OH)2
Another route involves hydroxymethylation of diethanolamine followed by hydrogenolysis.

N-Methyldiethanolamine production consists of the following stages:
N-Methyldiethanolamine synthesis.

Methylamine distillation and recycling.
Methylmonoethanolamine distillation and recycling.

Separation of commercial N-Methyldiethanolamine.
Synthesis is carried out in the liquid phase from ethylene oxide and methylamine in anhydrous medium, at a temperature of 60-90 °С and pressure up to 1 MPa.
The process is autocatalytic.
The technology is characterised by high quality commercial N-Methyldiethanolamine and low energy consumption.

General Manufacturing Information of N-Methyldiethanolamine:

Industry Processing Sectors:
Adhesive Manufacturing
All Other Basic Organic Chemical Manufacturing
Oil and Gas Drilling, Extraction, and Support activities
Paint and Coating Manufacturing
Petroleum Refineries
Printing Ink Manufacturing
Wholesale and Retail Trade

Handling and Storage of N-Methyldiethanolamine:

Protective measures:

Fire preventions:
No smoking.

Advice on general occupational hygiene:
Not to eat, drink and smoke in work areas.
Wash hands after use

Conditions for safe storage, including any incompatibilities:
Containers should be stored tightly sealed in a dry place.

Storage duration: 12 Months.

Stability and Reactivity of N-Methyldiethanolamine:

Reactivity:
No hazardous reactions if stored and handled as prescribed/indicated.

Chemical stability:
N-Methyldiethanolamine is stable when rules of storage and use are observed.

First Aid Measures of N-Methyldiethanolamine:

General informations:
Remove contaminated clothing.

Following inhaled:
Keep patient calm, remove to fresh air.
Seek medical attention.

Following skin contact:
Wash thoroughly with soap and water.

Following eye contact:
Wash affected eye.

Following ingestion:
Immediately rinse mouth.
Seek medical attention.

Indication of any immediate medical attention and special treatment needed Treatment:
No known specific antidote.

Accidental Release Measures of N-Methyldiethanolamine:

Personal precautions, protective equipment and emergency procedures:

Environmental precautions:
Do not discharge into drains/surface waters/groundwater.

Methods for cleaning up or taking up:

For large amounts:
Pump off product.

For residues:
Pick up with suitable absorbent material (e.g. sand, sawdust, general-purpose binder, kieselguhr).
Dispose of absorbed material in accordance with regulations.

Fire Fighting Measures of N-Methyldiethanolamine:

Extinguishing media:

Suitable extinguishing media:
Water spray, dry powder, alcohol-resistant foam, carbon dioxide.

Additional information:
Do not allow to reach sewage or effluent systems.

Exposure Controls/personal Protection:
Control parameters

Ingredients with workplace control parameters:

Exposure controls:

Appropriate engineering controls:
Change contaminated clothing.
Wash hands after working with substance.

Personal protective equipment:

Eye/face protection:
Safety glasses

Skin protection:

Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min

Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 60 min

Body Protection:
Use protective clothing

Control of environmental exposure:
Do not let product enter drains.

Spillage Disposal of N-Methyldiethanolamine:

Personal protection:
Filter respirator for organic gases and vapours adapted to the airborne concentration of N-Methyldiethanolamine.
Do NOT let this chemical enter the environment.

Collect leaking and spilled liquid in covered containers as far as possible.
Absorb remaining liquid in sand or inert absorbent.
Then store and dispose of according to local regulations.

Cleanup Methods of N-Methyldiethanolamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Disposal Methods of N-Methyldiethanolamine:
Recycle any unused portion of N-Methyldiethanolamine for N-Methyldiethanolamine approved use or return N-Methyldiethanolamine to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
N-Methyldiethanolamine's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations.
If N-Methyldiethanolamine is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Preventive Measures of N-Methyldiethanolamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Environmental precautions:
Do not let product enter drains.

Identifiers of N-Methyldiethanolamine:
CAS Number: 105-59-9
Beilstein Reference: 1734441
ChEMBL: ChEMBL3185149
ChemSpider: 7479
ECHA InfoCard: 100.003.012
EC Number: 203-312-7
MeSH: N-methyldiethanolamine
PubChem CID: 7767
RTECS number: KL7525000
UNII: 3IG3K131QJ
CompTox Dashboard (EPA): DTXSID8025591
InChI: InChI=1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
Key: CRVGTESFCCXCTH-UHFFFAOYSA-N
SMILES: CN(CCO)CCO

Synonym(s): 2,2′-Methyliminodiethanol, N,N-Bis(2-hydroxyethyl)methylamine, MDEA
Linear Formula: CH3N(CH2CH2OH)2
CAS Number: 105-59-9
Molecular Weight: 119.16
Beilstein: 1734441
EC Number: 203-312-7
MDL number: MFCD00002848
PubChem Substance ID: 24870762
NACRES: NA.22

Properties of N-Methyldiethanolamine:
Molecular weight: 119.1622
Appearance: Colorless liquid
Odor: Ammoniacal
Density: 1.038 g mL−1
Melting point: −21.00 °C; −5.80 °F; 252.15 K
Boiling point: 247.1 °C; 476.7 °F; 520.2 K
Solubility in water: Miscible
Vapor pressure: 1 Pa (at 20 °C)
Refractive index (nD): 1.4694
Viscosity: 101 mPa s (at 20°C)

Chemical formula: C5H13NO2
Molar mass: 119.164 g·mol−1
Appearance: Colorless liquid
Odor: Ammoniacal
Density: 1.038 g mL−1
Melting point: −21.00 °C; −5.80 °F; 252.15 K
Boiling point: 247.1 °C; 476.7 °F; 520.2 K
Solubility in water: Miscible
Vapor pressure: 1 Pa (at 20 °C)
Refractive index (nD): 1.4694
Viscosity: 101 mPa s (at 20°C)

vapor density: 4 (vs air)
Quality Level: 200
vapor pressure: 0.01 mmHg ( 20 °C)
Assay: ≥99%
autoignition temp.: 770 °F

expl. lim.:
99 %, 55 °F
~56 %, 23 °F
~8.8 %

refractive index: n20/D 1.469 (lit.)
bp: 246-248 °C (lit.)
density: 1.038 g/mL at 25 °C (lit.)
SMILES string: CN(CCO)CCO
InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
InChI key: CRVGTESFCCXCTH-UHFFFAOYSA-N

XLogP3-AA: -1.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 119.094628657
Monoisotopic Mass: 119.094628657
Topological Polar Surface Area: 43.7 Ų
Heavy Atom Count: 8
Complexity: 43.7
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Related compounds of N-Methyldiethanolamine:
Diethylhydroxylamine

Related alkanols:
N-Methylethanolamine
Dimethylethanolamine
Diethylethanolamine
Diethanolamine
N,N-Diisopropylaminoethanol
Triethanolamine
Bis-tris methane

Names of N-Methyldiethanolamine:

Regulatory process names:
2,2'-(Methylimino)diethanol
2,2'-(methylimino)diethanol; N-methyldiethanolamine
2,2'-methyliminodiethanol
2,2'-methyliminodiethanol
2-(N-2-Hydroxyethyl-N-methylamino)ethanol
Bis(2-hydroxyethyl) methyl amine
Ethanol, 2,2'-(methylimino)bis-
Ethanol, 2,2'-(methylimino)di-
MDEA
Methylbis(2-hydroxyethyl)amine
N,N-Bis(2-hydroxyethyl)methylamine
N,N-Di(2-hydroxyethyl)-N-methylamine
N-Methyl-2,2'-iminodiethanol
N-Methylaminodiglycol
N-Methyldiethanolamine
N-Methyldiethanolimine
N-Methyliminodiethanol

Translated names:
2,2'-(metilimino)dietanolis N-metildietanolaminas (lt)
2,2'-metiliminodietanol N-metildietanolamin (sl)
2,2'-μεθυλιμινοδιαιθανόλη N-μεθυλοδιαιθανολαμίν (el)
2,2’-(metilimino)dietanol N-metildietanolamin (hu)

IUPAC names:
2,2'-(Methylazanediyl)di(ethan-1-ol)
2,2'-(methylimino)diethanol
2,2'-(methylimino)diethanol
2,2'-Methyliminodiethanol
2,2'-methyliminodiethanol
2,2'-Methyliminodiethanol
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
2-[2-hydroxyethyl(methyl)amino]ethanol
Bis(2-hydroxyethyl)methylamine
MDEA
Methyldiethanolamine
Methyldiethanolamine
N,N(Bis-2 Hydroxy ethyl) Methylamine
N-Methyldiethanolamine
N-methyldiethanolamine

Preferred IUPAC name:
2,2′-(Methylazanediyl)di(ethan-1-ol)

Trade names:
2,2'-(Methylimino)diethanol
Amietol M12
Bis(2-hydroxyethyl) methyl amine
Diethanolmethylamine
Ethanol, 2,2'-(methylimino)bis- (9CI)
Ethanol, 2,2'-(methylimino)di- (6CI, 8CI)
Eve
MDEA
Methylbis(2-hydroxyethyl)amine
Methyldiethanolamin
Methyldiethanolamine
Methyliminodiethanol
N,N-Bis(2-hydroxyethyl)methylamine
N-Methylaminodiglycol
N-Methyldiethanolamine
N-METHYLDIETHANOLAMINE (MDEA)
N-Methyliminodiethanol

Other names:
Bis(2-hydroxyethyl)(methyl)amine

Other identifiers:
105-59-9
511262-76-3
603-079-00-5
944314-72-1

Synonyms of N-Methyldiethanolamine:
N-METHYLDIETHANOLAMINE
105-59-9
Methyldiethanolamine
Bis(hydroxyethyl)methylamine
2,2'-(Methylimino)diethanol
Methyl diethanolamine
Ethanol, 2,2'-(methylimino)bis-
N-Methylaminodiglycol
N-Methyliminodiethanol
591248-66-7
N-Methyl-2,2'-iminodiethanol
2,2'-Methyliminodiethanol
N-Methyldiethanolimine
2-[2-hydroxyethyl(methyl)amino]ethanol
USAF DO-52
N,N-Bis(2-hydroxyethyl)methylamine
Bis(2-hydroxyethyl)methylamine
Methylbis(2-hydroxyethyl)amine
Diethanolmethylamine
Methyliminodiethanol
Ethanol, 2,2'-(methylimino)di-
N-methyl diethanolamine
N,N-Di(2-hydroxyethyl)-N-methylamine
Bis(2-hydroxyethyl) methyl amine
NSC 11690
CCRIS 4843
2-(N-2-Hydroxyethyl-N-methylamino)ethanol
EINECS 203-312-7
BRN 1734441
UNII-3IG3K131QJ
3IG3K131QJ
N-Methylimino-2,2'-diethanol
DTXSID8025591
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
HSDB 6804
NSC-11690
EC 203-312-7
4-04-00-01517 (Beilstein Handbook Reference)
Ethanol,2'-(methylimino)di-
Ethanol,2'-(methylimino)bis-
WLN: Q2N1 & 2Q
N-methyl-diethanolamine
Mdea (diol)
N-Methyldethanolamne
methyl diethanol amine
MDE (CHRIS Code)
n-methyl-diethanol amine
N-methyl diethanol-amine
AMINO ALCOHOL MDA
di(hydroxyethyl)methylamine
SCHEMBL17605
bis-(Hydroxyethyl)methylamine
N-Methyl-2,2-iminodiethanol
N-Methyldiethanolamine, 99%
DTXCID605591
METHYLDIETHANOLAMINE, N-
CHEMBL3185149
N-Methyldiethanolamine, >=99%
2,2'-(methylazanediyl)diethanol
Etanol, 2,2'-(metilimino) bis-
NSC11690
NSC49131
NSC51500
METHYL DIETHANOLAMINE [INCI]
Tox21_201199
LS-389
MFCD00002848
N-METHYLDIETHANOLAMINE [HSDB]
NSC-49131
NSC-51500
STL281951
N-(2-Hydroxyethyl)-N-methylethanolam
AKOS009031354
N,N-bis-(2-hydroxyethyl)-methylamine
n-methyl-n,n-bis(2-hydroxyethyl)amine
AT34020
2,2'-(METHYLIMINO)BIS(ETHANOL)
NCGC00248955-01
NCGC00258751-01
CAS-105-59-9
2-[(2-hydroxy-ethyl)methyl-amino]-ethanol
FT-0663293
M0505
2,2'-(METHYLAZANEDIYL)BIS(ETHAN-1-OL)
2-Hydroxy-1-[(2-hydroxyethyl)methylamino]-ethyl
Q252344
J-523676
N-Methyldiethanolamine 1000 microg/mL in Ammonium Hydroxide
InChI=1/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H
2,2'-(Methylimino)diethanol
2,2′-Methyliminodiethanol
2,2'-Methyliminodiethanol
203-312-7 [EINECS]
Ethanol, 2,2'- (methylimino)bis-
Ethanol, 2,2'-(methylimino)bis-
MDEA
Methyl diethanolamine
N,N-Bis(2-hydroxyethyl)methylamine
N-Methyldiethanolamine
2-(2-hydroxyethyl-methylamino)ethanol
2-(2-hydroxyethyl-methyl-amino)ethanol
2-(N-2-Hydroxyethyl-N-methylamino)ethanol
2,2'-(Methylimino)bisethanol
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
2-[2-hydroxyethyl(methyl)amino]ethanol
203245-16-3 [RN]
2-Hydroxy-1-[(2-hydroxyethyl)methylamino]-ethyl
4-04-00-01517 [Beilstein]
Bis(2-hydroxyethyl) methyl amine
Bis(2-hydroxyethyl)methylamine
bis(2-hydroxyethyl)-methylammonium
bis-(Hydroxyethyl)methylamine
Bis(hydroxyethyl)methylamine
Diethanolmethylamine
Ethanol, 2,2'- (methylimino)di-
Ethanol, 2,2'-(methylimino)di-
ethanol, 2,2prime-methyliminodi-
Methylbis(2-hydroxyethyl)amine
METHYLDIETHANOLAMINE
METHYL-DIETHANOLAMINE
Methyldiethanolamine Reagent Grade
Methyliminodiethanol
Methyllimino, Methylamine, MDEA
N-(2-Hydroxyethyl)-N-methylethanolam
N,N-Di(2-hydroxyethyl)-N-methylamine
N-methyl diethanolamine
N-methyl-2,2′-iminodiethanol
N-Methyl-2,2'-iminodiethanol
N-Methyl-2,2-iminodiethanol
N-Methylaminodiglycol
N-Methyl-diethanol amine
N-Methyldiethanolamine (en)
N-Methyldiethanolamine 1000 µg/mL in Ammonium Hydroxide
N-Methyldiethanolamine, 1000 mg/L, 1 ml
N-Methyldiethanolamine, N-Methyl-2,2-iminobis(ethanol)
N-Methyldiethanolimine
N-Methylimino-2,2'-diethanol
N-METHYLIMINODIETHANOL