Hexamine, Formin, Urotropin; 1,3,5,7- Tetraazaadamantane; Ammonioformaldehyde; Aceto HMT; Aminoform; Ammoform; Cystamin; Cystogen; Formamine; Hexaform; Hexamethylenamine; Urotropin; Hexilmethylenamine; HMT; CAS NO:100-97-0

HEXAMIDINE DIISETHIONATE CAS Number: 659-40-5 Hexamidine Diisethionate What Is Hexamidine Diisethionate? In cosmetics and personal-care products, Hexamidine and Hexamidine Diisethionate function as a preservatives and are used in the formulation of hair, nail, and skin-care products, as well as eye makeup and baby products. Why is Hexamidine Diisethionate used in cosmetics and personal care products? Hexamidine Diisethionate helps cleanse the skin or prevent odor by destroying or inhibiting the growth of microorganisms. Scientific Facts: Hexamidine Diisethionate is an organic salt of Hexamidine. Hexamidine is soluble in water and insoluble in organic solvents. These ingredients function as preservatives, which help cleanse the skin or prevent odor by inhibiting the growth of or destroying microorganisms, such as bacteria, fungi and yeast. HEXAMIDINE DIISETHIONATE HEXAMIDINE DIISETHIONATE is classified as : Antifoaming Emollient Preservative Skin conditioning CAS Number 659-40-5 EINECS/ELINCS No: 211-533-5 Restriction (applies to EU only): VI/47 COSING REF No: 34260 Chem/IUPAC Name: 2-Hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1) Hexamidine Hexamidine Skeletal formula of hexamidine Ball-and-stick model Names IUPAC name 4,4'-[hexane-1,6-diylbis(oxy)]dibenzenecarboximidamide Other names 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzamidine Identifiers CAS Number 3811-75-4 check 3D model (JSmol) Interactive image ChEBI CHEBI:87184 ☒ ChEMBL ChEMBL25105 check ChemSpider 58639 check DrugBank DB03808 check PubChem CID 65130 UNII 3483C2H13H check CompTox Dashboard (EPA) DTXSID60191524 InChI[show] SMILES[show] Properties Chemical formula C20H26N4O2 Molar mass 354.446 Pharmacology ATC code D08AC04 (WHO) R01AX07 (WHO) R02AA18 (WHO) S01AX08 (WHO) S03AA05 (WHO) Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references Hexamidine is an antiseptic and disinfectant. Hexomedine is the trade name of a diisethionate solution (1/1.000) of hexamidine.[1] Hexamidine is used primarily as its diisethionate salt, which is more water-soluble than the dihydrochloride. The dihydrochloride was first synthesized and patented as a trypanocide for May & Baker in 1939. Its amoebicidal properties emerged in the 1990s. The exact mechanism of its biocidal action is unknown, but presumed similar to quaternary ammonium compounds, involving binding to the negatively charged lipid membranes of pathogens. Hexamidine and its shorter congener, propamidine, are used as antiseptics and preservatives in pharmaceuticals and cosmetics. They are particularly used for the topical treatment of acanthamoebiasis (Acanthamoeba keratitis) Molecular Weight of Hexamidine Diisethionate 606.7 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Hydrogen Bond Donor Countt of Hexamidine Diisethionate 8 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Hydrogen Bond Acceptor Countt of Hexamidine Diisethionate 12 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Rotatable Bond Countt of Hexamidine Diisethionate 15 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Exact Masst of Hexamidine Diisethionate 606.202936 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Monoisotopic Masst of Hexamidine Diisethionate 606.202936 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Topological Polar Surface Areat of Hexamidine Diisethionate 284 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Heavy Atom Countt of Hexamidine Diisethionate 40 Computed by PubChem Formal Charget of Hexamidine Diisethionate 0 Computed by PubChem Complexityt of Hexamidine Diisethionate 505 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Isotope Atom Countt of Hexamidine Diisethionate 0 Computed by PubChem Defined Atom Stereocenter Countt of Hexamidine Diisethionate 0 Computed by PubChem Undefined Atom Stereocenter Countt of Hexamidine Diisethionate 0 Computed by PubChem Defined Bond Stereocenter Countt of Hexamidine Diisethionate 0 Computed by PubChem Undefined Bond Stereocenter Countt of Hexamidine Diisethionate 0 Computed by PubChem Covalently-Bonded Unit Countt of Hexamidine Diisethionate 3 Computed by PubChem Compound of Hexamidine Diisethionate is Canonicalized Yes CAS number: 659-40-5 "Satisfactory" in all categories. Origin (s): Synthetic INCI name: HEXAMIDINE DIISETHIONATE EINECS / ELINCS number: 211-533-5 Classification: Regulated, Conservative Restriction in Europe: The maximum authorized concentration in ready-to-use cosmetic preparations is 0.1%. Its functions (INCI) Anti-foaming: Suppresses foam during manufacturing / reduces foaming in liquid end products Emollient: Softens and softens the skin Preservative: Inhibits the development of microorganisms in cosmetic products. Skin care agent: Keeps the skin in good condition Anti-Dandruff: Helps fight dandruff Antimicrobial: Helps slow the growth of microorganisms on the skin and inhibits the growth of microbes This ingredient is present in 0.06% of cosmetics. HEXAMIDINE (DIISETHIONATE) Each drug has one or more active principle (s) which gives it (s) a particular therapeutic effect. An active principle can be a set of chemical compounds or a natural plant, mineral or animal substance. Find in this section a medicine according to its active principle, also called active substance. Hexamidine can cause contact dermatitis. It is considered non-toxic in cosmetics for concentrations of 0.03% to 0.1%. HEXAMIDINE: MECHANISM OF ACTION Hexamidine (belonging to the family of diamidines) is a cationic antibacterial agent and exhibits surfactant properties. In vitro, its activity is exerted on Gram + bacteria and is not inhibited by pus, serum or organic debris. HEXAMIDINE: USE CASE Ophthalmically, hexamidine is used in the management of: bacterial blepharitis, bacterial conjunctivitis, dacryocystitis, bacterial keratoconjunctivitis. By the nasal route, hexamidine is used in the management of acute nasopharyngitis. Dermally, hexamidine is used in the management of bacterial skin conditions. By the ear, in combination with lidocaine, hexamidine is used in the management of otitis externa. By local route, in combination with lidocaine or tetracaine, hexamidine is used in the management of oral disorders.

CAS Number: 100-97-0
EC Number: 202-905-8
Formula:C6H12N4
Preferred IUPAC name: 1,3,5,7-Tetraazaadamantane
Substance name:Hexamethylenetetramine
Trade name:Hexamine
DESCRIPTION:

Hexamethylenetetramine, also known as methenamine, hexamine, or urotropin, is a heterocyclic organic compound with the formula (CH2)6N4.
Hexamine is highly soluble in water and polar organic solvents.
Hexamine has a cage-like structure similar to adamantane.
Hexamine is useful in the synthesis of other organic compounds, including plastics, pharmaceuticals, and rubber additives.
Hexamine sublimes in vacuum at 280 °C.
Hexamine also called methenamine, Hexamine is a white crystalline solid.
Hexamine is moderately soluble in water and is very soluble in most organic solvents.
Hexamine is a heterocyclic organic compound that can be prepared by a reaction of formaldehyde and ammonia.

C6H12N4 is a heterocyclic organic compound with the chemical name Hexamine.
It is also called Methenamine, Hexamethylenetetramine or Urotropin.

Hexamine acts as an anti-infective agent which is most commonly used to treat urinary tract infections.
Its anti-infective action is derived from the slow release of formaldehyde (CH2O) by hydrolysis at acidic pH of 0.2 molars.
Hexamine is an odourless colourless lustrous crystal or white crystalline powder which is hygroscopic.
Hexamine is a urinary tract antiseptic that is used as suppressive therapy for chronic or recurrent urinary tract infections.
Hexamine has not been linked to serum enzyme elevations or to instances of clinically apparent acute liver injury.
Hexamine is a heterocyclic organic compound with antibiotic activity.
In the body methenamine is converted to formaldehyde, a nonspecific bactericidal agent. Hexamine is typically used long-term to treat chronic urinary tract infections and to prevent the recurrence of infections.
Hexamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).





SYNTHESIS, STRUCTURE, REACTIVITY OF HEXAMINE:
Hexamine was discovered by Aleksandr Butlerov in 1859.
Hexamine is prepared industrially by combining formaldehyde and ammonia:
The reaction can be conducted in gas phase and in solution.
The molecule has a tetrahedral cage-like structure, similar to adamantane.
Four vertices are occupied by nitrogen atoms, which are linked by methylene groups.
Although the molecular shape defines a cage, no void space is available at the interior for binding other atoms or molecules, unlike crown ethers or larger cryptand structures.
The molecule behaves like an amine base, undergoing protonation and N-alkylation (e.g. quaternium-15).













APPLICATIONS OF HEXAMINE:
The dominant use of hexamethylenetetramine is in the production of powdery or liquid preparations of phenolic resins and phenolic resin moulding compounds, where it is added as a hardening component.
These products are used as binders, e.g. in brake and clutch linings, abrasive products, non-woven textiles, formed parts produced by moulding processes, and fireproof materials.
As an antibiotic, solid food tablet for cooking, in the production of other compounds, in rubber and textile adhesives, paints, lacquers, in the production of explosives, and as a corrosion inhibitor.
Hexamine is used in the production of liquid or powdery preparations of phenolic resins.
Hexamine is Used as binders in clutch and brake linings.
Hexamine is Used in the form of spray and cream to treat concomitant odour and excessive sweating.
Hexamine is Used in Grocott’s methenamine silver stain.
Hexamine is Used as a solid fuel.
Hexamine is Used as a food preservative.
Hexamine is Used as a primary ingredient in making RDX.
Hexamine is Used to prevent vulcanized rubber.
Hexamine is Used as a corrosion inhibitor for steel.

One of the major uses of Hexamine is in the manufacture of dinitrosopentamethylene-tetramine, a blowing agent for rubber.
Hexamine is used as a catalyst in the manufacture of Bakelite phenol formaldehyde molding powders.
Hexamine is used as a basic raw material in slurry explosives.
Hexamine has many other applications in the manufacture of plastics, paints, foundry resins, textiles, plywood, laminated sheets, cement, fertilizers, pesticides, solid fuel tablets etc.
Unstabilized Hexamine is used in adhesives, coatings and sealing compounds, in the preservation of hides, as cross-linking agent for hardening phenol-formaldehyde resins and vulcanizing rubber, as corrosion inhibitor for steel, as dye fixative, as fuel tablets for camping stoves, as stabilizer for lubricating and insulating oils, for manufacture of explosives, chemical detection of metals and as an urinary antiseptic.
Stabilized Hexamine is used in process industry, as per the requirements of specific customers.
Hexamethylenetetramine is prepared industrially by reacting formaldehyde and ammonia.

The reaction can be conducted in gas phase and in solution.

MAJOR APPLICATIONS:
• Curing agent for industrial phenolic resins (Novolac Resins)
• Rubber and lacquer film as cross-linking or vulcanizing agent
• Plastics industry
• Mining explosives
• Medicine and food industry
• Analytical chemistry
• As dry fuel - Fuel tablets
• Chemical intermediate/chemical synthesis
• Antiseptic agent for livestock
• Preservative & anti-microbial effect
• Corrosion inhibitor
• Foam manufacturing
• Synthetic resin industry
• Pharmaceuticals industry
• Photographic industry
• Metal industry
• Lubricant industry



Medical uses:
As the mandelic acid salt (methenamine mandelate) or the hippuric acid salt (methenamine hippurate), it is used for the treatment of urinary tract infection.
In an acidic environment, methenamine is believed to act as an antimicrobial by converting to formaldehyde.
A systematic review of its use for this purpose in adult women found there was insufficient evidence of benefit and further research is needed.
Methenamine acts as an over-the-counter antiperspirant due to the astringent property of formaldehyde.

Histological stains:
Methenamine silver stains are used for staining in histology, including the following types:
Grocott's methenamine silver stain, used widely as a screen for fungal organisms.
Jones' stain, a methenamine silver-Periodic acid-Schiff that stains for basement membrane, availing to view the "spiked" Glomerular basement membrane associated with membranous glomerulonephritis.
Solid fuel:
Together with 1,3,5-trioxane, hexamethylenetetramine is a component of hexamine fuel tablets used by campers, hobbyists, the military and relief organizations for heating camping food or military rations.
It burns smokelessly, has a high energy density of 30.0 megajoules per kilogram (MJ/kg), does not liquify while burning, and leaves no ashes, although its fumes are toxic.

Standardized 0.149 g tablets of methenamine (hexamine) are used by fire-protection laboratories as a clean and reproducible fire source to test the flammability of carpets and rugs.

Food additive:
Hexamethylene tetramine or hexamine is also used as a food additive as a preservative (INS number 239).
It is approved for usage for this purpose in the EU, where it is listed under E number E239, however it is not approved in the USA, Russia, Australia, or New Zealand.

Reagent in organic chemistry:
Hexamethylenetetramine is a versatile reagent in organic synthesis.
It is used in the Duff reaction (formylation of arenes), the Sommelet reaction (converting benzyl halides to aldehydes), and in the Delepine reaction (synthesis of amines from alkyl halides).

Explosives:
Hexamethylenetetramine is the base component to produce RDX and, consequently, C-4 as well as Octogen, hexamine dinitrate, hexamine diperchlorate and HMTD.

Historical uses:
Hexamethylenetetramine was first introduced into the medical setting in 1895 as a urinary antiseptic.
However, it was only used in cases of acidic urine, whereas boric acid was used to treat urinary tract infections with alkaline urine.
Scientist De Eds found that there was a direct correlation between the acidity of hexamethylenetetramine's environment and the rate of its decomposition.
Therefore, its effectiveness as a drug depended greatly on the acidity of the urine rather than the amount of the drug administered.
In an alkaline environment, hexamethylenetetramine was found to be almost completely inactive.

Hexamethylenetetramine was also used as a method of treatment for soldiers exposed to phosgene in World War I.
Subsequent studies have shown that large doses of hexamethylenetetramine provide some protection if taken before phosgene exposure but none if taken afterwards.




CHEMICAL AND PHYSICAL PROPERTIES OF HEXAMINE:
Chemical formula: C6H12N4
Molar mass: 140.186 g/mol
Appearance: White crystalline solid
Odor: Fishy, ammonia like
Density: 1.33 g/cm3 (at 20 °C)
Melting point: 280 °C (536 °F; 553 K) (sublimes)
Solubility in water: 85.3 g/100 mL
Solubility: Soluble in chloroform, methanol, ethanol, acetone, benzene, xylene, ether
Solubility in chloroform: 13.4 g/100 g (20 °C)
Solubility in methanol: 7.25 g/100 g (20 °C)
Solubility in ethanol: 2.89 g/100 g (20 °C)
Solubility in acetone: 0.65 g/100 g (20 °C)
Solubility in benzene: 0.23 g/100 g (20 °C)
Acidity (pKa): 4.89
Flash point: 250 °C (482 °F; 523 K)
Autoignition temperature: 410 °C (770 °F; 683 K)
CAS Number: 100 – 97 – 0
EINECS Number: 202 – 905 – 8
Chemical Name :Hexamethylene tetramine
Chemical Classification: Amine / Cyclic amine
Formula: C6H12N4
Molecular weight. 140.19
Shipping Name: Hexamine
Codes / Label: Flammable solid, class – 4.1
UN Number: 1328
Description: White crystalline odorless solid.
Molecular Weight: 140.19
XLogP3-AA: 0.3
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 0
Exact Mass: 140.106196400
Monoisotopic Mass: 140.106196400
Topological Polar Surface Area: 13 Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 84.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Product Standard:
Appearance: White crystals
Purity (%): No less than 99.5
Water Content (%): 0.5 or less
PH（PH）: No less than 7.5
Color Number (APHA): 10 or less
Ash Content (%): 0.01 or less
Ammonium Salt (%): 0.001 or less
Sulfate（SO4）（%）: 0.02
Chloride（Cl）（%）: 0.015
Heavy Metal（Pb）（%）: 0.001


SAFETY INFORMATION ABOUT HEXAMINE:

Hexamine Hazards:
The routes of exposure to Hexamine include; eye contact, skin contact, inhalation and ingestion.

Eye exposure to hexamine may result in redness and slight abrasive damage.
The discomfort is only expected to be short term

Skin contact with hexamine is not thought to have harmful health effects, but irritation can occur after repeated or prolonged exposure, with redness and swelling being possible symptoms.
If an individual has open cuts or wounds however, they should avoid handling the chemical without the proper PPE as this can result in the chemical entering the bloodstream which will produce greater harm than skin contact alone.

Inhalation of hexamine is mainly a concern for those with an already compromised respiratory function with healthy individuals likely to be unharmed.

When the hexamine evaporates and the ammonia component evaporates into a vapour however, inhalation will be more harmful; causing coughing, vomiting and reddening of the lips mouth, nose and throat.
High concentrations of vapour inhalation may cause difficulty in breathing, tightness in the chest, lung damage and even death by suffocation.

In small quantities, the human metabolism allows for detoxification of ammonia.
In doses larger than 1-2g however, ingestion is likely to lead to; nausea, vomiting and diarrhoea.
Very large doses may produce a drop in blood pressure, collapse, central nervous system disorders, spasms, drowsiness, respiratory paralysis and haemolysis.

Hexamine Safety:
If hexamine enters the eye, flush out the eyes immediately with fresh running water remembering to wash under the eyelids as well.
Removing contact lenses should only be performed by skilled personnel.
Seek medical attention if pain persists.
In the event of skin exposure; remove all contaminated clothing, footwear and accessories and cleanse the affected area with plenty of soap and water.
Contaminated clothing must be washed prior to wearing again.
Seek medical attention if irritation occurs.
If hexamine dust is inhaled, remove the person from the contaminated area and encourage the patient to blow their nose to ensure a clear passage for breathing.
If irritation persists, seek medical attention.
In the event of ingestion, vomiting should not be induced.
If vomiting occurs, lean the patient forward or place them on their left side to maintain an open airway and to prevent aspiration.
Observe the patient and seek medical advice.

Hexamine Safety Handling:
Safety showers and emergency eyewash fountains should be accessible in the immediate area of the potential exposure to the chemical.
Ensure the area has adequate ventilation and install local exhaust ventilation if necessary.
Wear proper PPE, such as safety glasses with side shields, chemical goggles, gloves, overalls, aprons, and respirators.
Some plastic PPE is not recommended when handling hexamine, as they may produce static electricity.




SYNONYMS OF HEXAMINE:
Depositor-Supplied Synonyms:
methenamine
Hexamethylenetetramine
100-97-0
Hexamine
Urotropine
Aminoform
Urotropin
Hexamethylenamine
Hexamethylene tetramine
1,3,5,7-Tetraazaadamantane
HMTA
Methenamin
Uritone
Hexamethylenetetraamine
Formamine
Aminoformaldehyde
Ammonioformaldehyde
Ammoform
Antihydral
Cystamin
Cystogen
Duirexol
Hexaform
Hexaloids
Metramine
Resotropin
Uratrine
Urodeine
Xametrin
Formin
Heterin
Hexasan
Uramin
Preparation AF
Hexamethyleneamine
Hexilmethylenamine
Hexa-Flo-Pulver
Ekagom H
methenaminum
Aceto HMT
Herax UTS
Hexamethylentetramin
Metenamina
Hexaminum
Formin (heterocycle)
Nocceler H
Sanceler H
Hexamine (heterocycle)
Vulkacit H 30
Hexamethylentetraminum
1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane
Hexamethylentetramine
Hexasan (VAN)
S 4 (heterocycle)
Hexamethylenetetraminum
Uro-phosphate
1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~]decane
Esametilentetramina
Metenamine
Methamin
Vesaloin
Hexa (vulcanization accelerator)
1,3,5,7-Tetraazatricyclo (3.3.1.1(3,7))decane
HMT
Hexamine (JAN)
Hexamine (TN)
1,3,5,7-Tetraazatricyclo(3.3.1.13,7)decane
Hexamethylenetetramine (aliphatic)
Methenamine (USP/INN)
NSC-26346
J50OIX95QV
1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 37))decane
CHEBI:6824
H.M.T.
INS NO.239
INS-239
1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane
Formin (the heterocyclic compound)
NSC26346
Silver Methenamine
1,3,5,7-tetraazatricyclo[3.3.1.1^{3,7}]decane
MFCD00006895
NSC-403347
1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 3,7))decane
NCGC00094719-04
E239
HEXAMINE [JAN]
Hexamine Silver
DSSTox_CID_692
E-239
Hexamethylenetetramine-palladium chloride adduct
Methenamine Silver
DSSTox_RID_75739
DSSTox_GSID_20692
1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane
Caswell No. 482
Methenamine [USAN:INN]
Sanceler HT
Metenamina [INN-Spanish]
Methenaminum [INN-Latin]
Heksa K
Hexamine Superfine
Nocceler H-PO
Sanceler HT-PO
Hexa B
1,3,5,7-Tetraazatricyclo(3.3.1.13,7)decane hydroiodide
CAS-100-97-0
Esametilentetramina [Italian]
Hexamethylentetramin [German]
SMR000857139
Cohedur H 30
CCRIS 2297
HSDB 563
hexamethylene-tetramine
NSC403347
Rhenogran HEXA 80
Thixon 715B
1,3,5,7-Tetraazotricyclo[3.3.1.13,7]decane
SR-05000002024
Methenamine [USP:INN]
1,3,5,7-Tetraazatricyclo[3.3.1.1{3,7}]decane
EINECS 202-905-8
NSC 26346
UN1328
UNII-J50OIX95QV
1,3,5,7-Tetraazatricyclo[3.3.1.1(sup 3,7)]decane
EPA Pesticide Chemical Code 045501
NSC 403347
Hexamethylamine
Naphthamine
Urisol
Carin
EL 10 (corrosion inhibitor)
Hexamethylenetetramine solutions
AI3-09611
HEXAMETHYLENETETRAMINE, ACS
EL 10
Prestwick_79
Vulkacit H30
1,3,5,7-Tetraazatricyclo[3.3.1.13,7 ]decane
Grasselerator 102
Cystex (Salt/Mix)
hexam-ethylenetetraamine
hexamethylene tetraamine
Spectrum_000991
METHENAMINE [MI]
Spectrum2_000827
Spectrum3_001730
Spectrum4_000872
Spectrum5_001603
Methenamine (Mandelamine)
METHENAMINE [INN]
Formaldehyde-ammonia 6:4
[16]-Adamazane, INN
component of Uro-Phosphate
METHENAMINE [HSDB]
METHENAMINE [INCI]
Uro-phosphate (Salt/Mix)
1,5,7-Tetraazaadamantane
EC 202-905-8
Hexamethylentetramin(german)
METHENAMINE [VANDF]
Hexamethylenetetramine, 8CI
METHENAMINE [MART.]
1,3,5,7-tetraazatricyclo[3.3.1.1?,?]decane
SCHEMBL33785
BSPBio_003380
Hexamethylenetetramine, tech.
KBioGR_001563
KBioSS_001471
METHENAMINE [USP-RS]
METHENAMINE [WHO-DD]
Hexamethylenetetramine [UN1328] [Flammable solid]
MLS001332361
MLS001332362
MLS002207085
DivK1c_000322
SPECTRUM1500394
SPBio_000753
Hexamethylenetetramine, BioXtra
CHEMBL1201270
DTXSID6020692
GTPL10913
HMS501A04
KBio1_000322
KBio2_001471
KBio2_004039
KBio2_006607
KBio3_002600
NINDS_000322
HMS1920L13
HMS2091D08
HMS2233B09
HMS3371O15
HMS3652A05
HMS3715D17
METHENAMINE [EP MONOGRAPH]
Pharmakon1600-01500394
METHENAMINE [USP MONOGRAPH]
HY-B0514
STR00289
Tox21_113455
Tox21_201606
Tox21_300502
CCG-40289
Hexamethylenetetramine, LR, >=99%
NSC757101
s3139
STL197471
ZINC86040406
AKOS000120003
AKOS005169648
Tox21_113455_1
Urotropine 100 microg/mL in Methanol
DB06799
NSC-757101
IDI1_000322
NCGC00094719-01
NCGC00094719-02
NCGC00094719-03
NCGC00094719-05
NCGC00094719-06
NCGC00094719-08
NCGC00254463-01
NCGC00259155-01
SBI-0051439.P003
FT-0627024
FT-0669190
H0093
Hexamethylenetetramine, ReagentPlus(R), 99%
SW199604-2
1,5,7-Tetraazatricyclo[3.3.1.13,7]decane
D00393
Hexamethylenetetramine, ACS reagent, >=99.0%
Q71969
AB00052038_08
AB00052038_09
1,3,5,7-tetraaza-tricyclo[3.3.1.13,7]decane
1,3,5,7-tetraazatricyclo-[3.3.1.13,7]decane
1,3,5,7-tetraazatricyclo[3,3,1,13,7]decane
1,5:3,7-Dimethano-1,3,5,7-tetraazacyclooctane
AE-641/00560026
WLN: T66 B6 A B-C 1B I BN DN FN HNTJ
Hexamethylenetetramine [UN1328] [Flammable solid]
Hexamethylenetetramine, analytical reference material
Hexamethylenetetramine, p.a., ACS reagent, 99.0%
Hexamethylenetetramine, SAJ first grade, >=98.5%
J-000293
J-521456
SR-05000002024-1
SR-05000002024-3
1,3,5,7-tetraaza-tricyclo[3.3.1.1*3,7*]decane
1,3,5,7-Tetraazatricyclo-[3.3.1.1(3,7)]decane
BRD-K30114692-001-10-0
Hexamethylenetetramine, JIS special grade, >=99.0%
F2173-0429
Z362014242
Methenamine, European Pharmacopoeia (EP) Reference Standard
1,3,5,7-TETRAAZATRICYCLO(3.3.1.1 SUP(3,7))DECANE
Methenamine, United States Pharmacopeia (USP) Reference Standard
Hexamethylenetetramine, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.0%
Hexamethylenetetramine, meets analytical specification of Ph.??Eur., BP, 99-100.5% (calc. to the dried substance)
Hexamethylenetetramine, puriss. p.a., Reag. Ph. Eur., >=99.5% (calc. to the dried substance)
1,3,5,7-tetraazaadamantane
1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)-]decane
1,3,5,7- tetrazatricyclo(3.3.1.1*3.7)decane
aceto HMT (= aceto hexamethylenetetramine)
aminoform
aminoformaldehyde
ammoform
ammonioformaldehyde
amoform
antihydral
carin
cystamin
cystogen
duirexol
ekagom H
formaldehyde:ammonia 6:4
formamine
formin
formine
herax UTS
heterin
hexa (= hexamethylenetetramine)
hexa-flo-pulver
hexaform
hexamethylenamine
hexamethyleneamine
Hexamethylenetetramine
hexasan
hexilmethylenamine
HMT (= hexamethylenetetramine)
HMTA (= hexamethylenetetramine)
mandelamine
methamin
methenamine
metheneamine
metramine
naphthamine
preparation AF
resotropin
URAMIN
uratrine
urisol
uritone
urodeine
urotropin
urotropine
vesaloin
vesalvine
vulkacit H30
xametrin
xametrine

Hexamine, also known as methenamine, is a chemical compound with the molecular formula C6H12N4.
Hexamine is a white crystalline solid that is highly soluble in water and has a characteristic odor.
Hexamine is derived from formaldehyde and ammonia and is commonly used in various industrial and commercial applications due to its unique properties.

CAS Number: 100-97-0
EC Number: 202-905-8



APPLICATIONS


Hexamine tablets are used for outdoor cooking and heating during camping.
Military personnel rely on hexamine tablets for field rations and warmth.
Hexamine is a go-to solution for emergency heating during power outages.
Survival kits often include hexamine tablets for fire starting and warmth.

Hexamine's role in explosives contributes to their detonation properties.
Hexamine strengthens rubber products as a vulcanizing agent in the rubber industry.
Hexamine is vital in producing synthetic resins used in adhesives and coatings.
The textile industry benefits from hexamine's crease resistance enhancement.

Hexamine's antiseptic properties are utilized in medical treatments.
Hexamine catalyzes reactions, aiding in the production of various compounds.
Hexamine cross-links polymers, improving plastics and resin materials.
Water treatment employs hexamine for pH control and corrosion prevention.

Historically, hexamine was used in photographic developers and fixers.
Adhesive formulations are improved by incorporating hexamine.
Its dehydrating properties are valuable in moisture-sensitive processes.
Hexamine tablets are a reliable choice for igniting fires quickly.

In textile printing, hexamine enhances color fastness.
Agriculture benefits from hexamine as a chemical intermediate.
Hexamine contributes to the synthesis of certain pharmaceuticals.
Analytical chemistry employs hexamine as a reagent for ion determination.
Hexamine enhances properties in fiberboard production and electronics.
Hexamine generates gases for inflating airbags in vehicles.

In oil and gas, Hexamine prevents corrosion in pipelines and equipment.
Hexamine is explored for flame-retardant applications in electronics.
Hexamine serves as a precursor in the production of specific fertilizers.

Hexamine tablets are a reliable choice for igniting charcoal grills and barbecues.
In marine and shipping industries, hexamine is used as a corrosion inhibitor for engine cooling systems.

Hexamine's stabilizing effect on resins improves their shelf life and handling characteristics.
Hexamine contributes to the adhesion and bonding properties of coatings and paints.
Hexamine acts as a catalyst in the production of foamed plastics used in insulation.
Hexamine finds use in the synthesis of specialty chemicals, such as corrosion inhibitors and dye intermediates.

Hexamine's water treatment applications extend to cooling tower systems to prevent scaling and corrosion.
Hexamine is utilized in the manufacture of tablet disinfectants for water purification.
Hexamine is used as a fuel in solid-fuel rocket propellants due to its controlled energy release.

In the automotive industry, hexamine is used in airbag inflators for rapid gas generation during deployment.
Hexamine serves as a corrosion inhibitor for protecting metals in industrial water systems and pipelines.
Hexamine's combustion properties are applied in flameless ration heaters for military field rations.

In mining, hexamine is used as a flotation reagent to separate valuable minerals from ores.
Hexamine finds a place in the production of brake linings, improving friction properties in automotive brakes.
Hexamine is used in the synthesis of melamine-formaldehyde resins for durable laminates and coatings.
In petroleum refining, hexamine is employed in desulfurization processes to remove sulfur compounds.
Hexamine acts as a curing agent in foundry resins, aiding in mold and core production for metal casting.

Hexamine's antimicrobial properties are harnessed in wood preservation treatments.
Hexamine plays a role in the production of synthetic diamond abrasives for industrial applications.
Hexamine is used in the production of certain types of explosives, such as hexamine nitrate.
Hexamine contributes to the production of fuel tablets used in beverage can stoves and portable heaters.
Hexamine is employed as a stabilizer in emulsions and dispersions in the cosmetic industry.

In electronics, Hexamine can be used in circuit board production for flame-resistant materials.
Hexamine's controlled gas release is utilized in airbag cushions for vehicle safety systems.
Hexamine is explored for its potential in wastewater treatment to remove heavy metals.

Hexamine is used in the production of firework compositions, contributing to colorful and controlled pyrotechnic displays.
Hexamine acts as a corrosion inhibitor in cooling systems of power plants to prevent damage to critical components.
Hexamine is employed as a binder in the manufacture of carbon electrodes used in electrolytic cells.

In the leather industry, it is used as a curing agent for tanning agents, enhancing leather's quality and durability.
Hexamine's gas-releasing properties find use in airbag modules for rapid inflation during vehicle collisions.
Hexamine is utilized in the production of automotive catalytic converters, aiding in pollutant emission reduction.
Hexamine is explored as a potential fuel for fuel cells, contributing to clean and efficient energy conversion.

In the construction industry, hexamine is added to cement admixtures to improve workability and strength.
Hexamine serves as a nitrogen source in certain microbial culture media used in microbiology research.
Hexamine is used as a chelating agent in the recovery of precious metals from electronic waste.
Hexamine contributes to the formulation of metal cleaning compounds, removing oxides and impurities.

In the textile industry, hexamine enhances the color retention and colorfastness of fabrics.
Hexamine is employed as a cross-linking agent in the synthesis of epoxy resins for coatings and adhesives.
Hexamine acts as a binder in the production of ceramic materials, enhancing their mechanical properties.
Hexamine's gas-generating properties are utilized in inflating life-saving devices like life jackets.

In the food industry, it can be used as a preservative in certain products to extend shelf life.
Hexamine is a component of artificial urinary calculi used in testing and calibrating medical equipment.
Hexamine serves as a pH buffer in chemical reactions and processes requiring controlled acidity or alkalinity.

Hexamine is used as a corrosion inhibitor in steam generation systems to protect metal surfaces.
Hexamine finds use in the production of controlled-release fertilizers, enhancing nutrient availability to plants.
Hexamine is explored for potential use in the production of biodegradable plastics.
In the production of specialty papers, it can be used to improve wet-strength properties.

Hexamine's presence in detergents aids in soil removal and dispersion during washing.
Hexamine is utilized in the manufacturing of insulating materials used in electronics and electrical equipment.
Hexamine's diverse properties find applications in various research fields, from materials science to analytical chemistry.

Hexamine is a key component in the production of urea-formaldehyde resins used in wood products like particleboard and plywood.
Hexamine is employed as a cross-linking agent in the formulation of adhesives used in woodworking and construction.
In the automotive industry, hexamine is utilized in catalytic converter coatings to reduce harmful emissions.

Hexamine is used in the manufacture of gas masks and respiratory protective equipment filters for defense and industrial applications.
Hexamine serves as a reagent in the synthesis of complex organic compounds in pharmaceutical research.
In the manufacture of automotive tires, hexamine can be used to improve the bonding of rubber compounds.
Hexamine's role as a corrosion inhibitor extends to marine applications, protecting shipboard equipment and structures.

Hexamine is utilized in the production of water-based cutting fluids and coolants for metalworking processes.
Hexamine is added to certain fuel formulations to enhance combustion efficiency and reduce engine emissions.
In the cosmetic industry, it can be used as a stabilizer in emulsions and creams, improving product texture.

Hexamine is employed in the production of polymeric materials with controlled release properties, such as drug delivery systems.
Hexamine finds use in the production of refractory materials used in high-temperature applications like furnaces and kilns.
Hexamine's cross-linking properties contribute to the strength and durability of rubber conveyor belts used in industries.

In the mining industry, hexamine is used in ore flotation processes to separate valuable minerals from gangue.
Hexamine can be added to gas and oil well drilling fluids as a corrosion inhibitor and stabilizer.
Hexamine's role as a flame retardant makes it valuable in the production of fire-resistant textiles and materials.

In the aerospace industry, it is used in rocket propellants for controlled energy release during combustion.
Hexamine is explored for its potential in the treatment of wastewater containing heavy metal pollutants.

Hexamine is used in the production of epoxy composites for aerospace and engineering applications.
Hexamine's controlled gas generation properties are utilized in airbag cushions for passenger safety.
In the electronics industry, it can be used as a resin additive to enhance flame resistance in circuit boards.
Hexamine's binding properties contribute to the formulation of foundry cores used in metal casting.

Hexamine is added to some toothpaste formulations as an abrasive for cleaning and polishing teeth.
Hexamine's gas-releasing characteristics make it useful in inflating airbags in safety vests and lifebuoys.
In the energy sector, hexamine is explored for its potential use as a clean-burning fuel source in solid oxide fuel cells.



DESCRIPTION


Hexamine, also known as methenamine, is a chemical compound with the molecular formula C6H12N4.
Hexamine is a white crystalline solid that is highly soluble in water and has a characteristic odor.
Hexamine is derived from formaldehyde and ammonia and is commonly used in various industrial and commercial applications due to its unique properties.

Hexamine, also known as methenamine, is a versatile chemical compound with a distinct crystalline appearance.
Hexamine forms colorless, odorless crystals that are highly soluble in water.
Hexamine derives its name from its structure, consisting of six carbon atoms linked to four nitrogen atoms.
Hexamine is commercially available in the form of white powder or tablets.

Hexamine has a wide range of applications across industries due to its unique properties.
When heated, hexamine undergoes sublimation, meaning it transitions directly from a solid to a gas.
Hexamine is known for its ability to release nitrogen gas when heated, making it useful in various applications.

Hexamine's combustion releases energy and heat, making it suitable for heating and cooking in outdoor settings.
Hexamine has a distinctive mild, ammonia-like odor when burned.
Hexamine tablets are commonly used by campers, hikers, and military personnel as portable heat sources and cooking fuel.

Hexamine's heat-releasing properties are harnessed in emergency situations and survival kits.
Hexamine's stability and low toxicity make it a preferred choice for many applications.
In the rubber industry, hexamine acts as a vulcanizing agent, enhancing the durability and strength of rubber products.

Hexamine is used as a cross-linking agent in the production of synthetic resins, contributing to their toughness and rigidity.
Hexamine plays a role in the textile industry by improving crease resistance and dimensional stability of fabrics.

Hexamine's antiseptic properties make it valuable in medical applications, particularly for treating urinary tract infections.
Hexamine's molecular structure and properties have led to its use in various chemical reactions as a catalyst or reactant.
Hexamine's role in explosives lies in its ability to release nitrogen gas upon heating, contributing to explosive power.

Hexamine has been historically used in photography as part of photographic developers and fixers.
Hexamine has a long shelf life and is relatively stable when stored under proper conditions.
Its water-soluble nature makes it useful in water treatment processes, helping to control pH and prevent corrosion.
Hexamine's dehydrating properties find applications in diverse industries, including the production of plastics and resins.

As a fire starter, hexamine tablets offer a reliable ignition source for campfires and stoves.
Hexamine's inclusion in cigarette filters aims to reduce the content of tar and nicotine in cigarette smoke.
Hexamine's multifaceted properties make it a valuable chemical compound across various sectors, from outdoor adventures to industrial processes.



PROPERTIES


Molecular Formula: C6H12N4
Molecular Weight: 140.19 g/mol
Appearance: White crystalline solid
Odor: Characteristic ammonia-like odor when burned
Solubility: Highly soluble in water
Melting Point: Approximately 263-281°C (505-538°F)
Boiling Point: Decomposes without a well-defined boiling point
Density: Approximately 1.33 g/cm³ (at 20°C)
Sublimation Point: Begins to sublime around 280°C (536°F)
Vapor Pressure: Low vapor pressure at room temperature



FIRST AID


Inhalation:

If inhaled, move the affected person to fresh air immediately.
If breathing is difficult, provide oxygen if available and seek medical attention.
If the person's breathing has stopped, administer artificial respiration and seek medical help.


Skin Contact:

Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If irritation, redness, or rash develops, seek medical attention.
If the compound has entered under the skin (subcutaneous), seek medical assistance.


Eye Contact:

Rinse the eyes gently but thoroughly with water for at least 15 minutes, holding the eyelids open.
Remove contact lenses if present and easy to do so, but continue rinsing.
Seek immediate medical attention if irritation, redness, or pain persists.


Ingestion:

Do not induce vomiting unless instructed by medical professionals.
Rinse the mouth with water if the person is conscious and able to swallow.
Seek medical attention immediately. Provide medical personnel with information about the compound ingested.



HANDLING AND STORAGE


Handling:

Ventilation:
Work with hexamine in a well-ventilated area or use local exhaust ventilation to prevent the buildup of vapors or dust in the air.

Personal Protective Equipment:
Wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and protective clothing, to minimize skin and eye contact.

Avoid Inhalation:
Avoid inhaling hexamine dust, fumes, or vapors.
Use respiratory protection, such as a dust mask or respirator, when working with the compound in areas with inadequate ventilation.

Prevent Contact:
Avoid skin and eye contact with hexamine.
If handling the compound, do not touch your face, especially your eyes, nose, or mouth, without washing your hands first.

No Smoking:
Prohibit smoking, eating, or drinking in areas where hexamine is being handled to prevent ingestion or inhalation of the compound.

Work Practices:
Minimize dust generation by using appropriate handling techniques, such as using closed systems or wet methods.

Static Electricity:
Take precautions to avoid static electricity buildup, which could ignite hexamine dust.
Use grounding equipment if necessary.

Spill Management:
In case of spills, use appropriate spill containment measures to prevent the spread of hexamine.
Clean up spills promptly and safely.


Storage:

Store in a Cool, Dry Place:
Store hexamine in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and open flames.

Containers:
Keep hexamine in tightly closed containers to prevent contamination and exposure to moisture.

Separation:
Store hexamine away from incompatible materials, such as strong acids, strong bases, and oxidizing agents.

Labeling:
Clearly label storage containers with the name of the substance and appropriate hazard warnings.

Fire Protection:
Store hexamine away from flammable materials and ignition sources to prevent fire hazards.

Controlled Access:
Limit access to storage areas to authorized personnel only, and keep storage areas locked when not in use.

Emergency Procedures:
Ensure that appropriate emergency equipment, such as spill control materials and fire extinguishers, are available near storage areas.

Segregation:
Segregate hexamine from food, beverages, and medical supplies to prevent cross-contamination.


Transportation:

Compliance:
Follow all transportation regulations and guidelines for handling and transporting hazardous materials, if applicable.

Packaging:
Use approved packaging materials and containers for transporting hexamine to prevent leakage or breakage.

Documentation:
Ensure that all required documentation, including safety data sheets (SDS) and shipping documents, accompany the shipment.

Avoid Rough Handling:
Handle transportation containers carefully to avoid damage and potential leaks.



SYNONYMS


Methenamine
Urotropine
Hexamethylenetetramine
Formin
Aminoform
Aminoformaldehyde
Hexamine
Urotropin
Urotem
Urotropinum
Hexamethyleneamine
Hexaminol
Hexamethylenamine
Aminoformyl
Cystogen
Formamine
HMTA
Methylenamin
Uretropin
Urotropinum
Urotrupin
Hexamethylenamin
Hexaform
Methenamine Solid
Hexamethylenetetraamine
Urotropine
Aminohexamethylene
Aminoformaldehyde
Methenamine
Hexamethylenamine
HMTA
Aminoform
Hexamethylenetetramine
Urotrupin
Hexamine
Methenamine solid
Aminoformyl
Formamine
Urotropin
Hexaminol
Urotropinum
Urotropinum
Uretropin
Hexaform
Hexaminum
Hexamethylenamin
Methylenamin
Aminoformaldehyde
Aminoform
Cystogen

Hexamethylenetetramine; Hexamine; 1,3,5,7- Tetraazaadamantane; Ammonioformaldehyde; Aceto HMT; Aminoform; Ammoform; Cystamin; Cystogen; Esametilentetramina (Italian); Formamine; Formin; Hexaform; Urotropin; Hexamethyleneamine; Hexamethylentetramin (German); Hexilmethylenamine; HMT; Methamin; Methenamine; Resotropin; Uritone; Urotropine; Esametilentetramina (Italian) CAS NO:100-97-0

HEXANAL, N° CAS : 66-25-1, Nom INCI : HEXANAL, Nom chimique : Caproic Aldehyde, N° EINECS/ELINCS : 200-624-5. Agent masquant : Réduit ou inhibe l'odeur ou le goût de base du produit

ETHYL HEXANOATE, N° CAS : 123-66-0, Nom INCI : ETHYL HEXANOATE, Nom chimique : Ethyl hexanoate; Ethyl caproate, N° EINECS/ELINCS : 204-640-3. Ses fonctions (INCI) : Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques. Noms français : HEXANOATE D'ETHYLE; Hexanoate d'éthyle. Noms anglais : ETHYL CAPROATE;Ethyl hexanoate ; HEXANOIC ACID, ETHYL ESTER

Hexanedihydrazide is a chemical used for cross-linking water-based emulsions.
Hexanedihydrazide can also be used as a hardener for certain epoxy resins.
Hexanedihydrazide is a symmetrical molecule with a C4 backbone, and the reactive group is C=ONHNH2.

CAS Number: 1071-93-8
EC Number: 213-999-5
Molecular Formula: C6H14N4O2
Molecular Weight: 174.20 g/mol

Synonyms: Hexanedihydrazide, Adipic dihydrazide, 1071-93-8, Adipic acid dihydrazide, Adipohydrazide, Hexanedihydrazide, Hexanedioic acid, dihydrazide, Adipyl hydrazide, Hexanediohydrazide, Adipic acid, dihydrazide, Adipoyldihydrazine, adipoyl dihydrazide, VK98I9YW5M, DTXSID0044361, Hexanedioic acid, 1,6-dihydrazide, NSC 3378, NSC-3378, EINECS 213-999-5, NSC 29542, NSC-29542, AI3-22640, WLN: ZMV4VMZ, EC 213-999-5, MFCD00007614, Adipodihydrazide, Adip dihydr, adipic hydrazide, Adipoyl hydrazide, adipic dihydrazone, Hexanedihydrazide #, Adipic aciddihydrazide, Adipic acid dihyrazide, Hexanedioic dihydrazide, AJICURE ADH, QUALIMER ADH, ULTRALINK HYDRAZIDE, Hexanedioic acid dihydrazide, SCHEMBL49856, Adipic Acid Dihydrazide (ADH), CHEMBL3185968, DTXCID8024361, SCHEMBL11037942, AMY3771, NSC3378, 1,4-Butanedicarboxylic dihydrazide, BK 1000Z, BT 1000Z, NSC29542, STR02658, Tox21_301067, BBL022965, STK709135, ADIPIC ACID DIHYDRAZIDE [INCI], AKOS000267183, NCGC00248276-01, NCGC00257525-01, CAS-1071-93-8, A0170, Adipic acid dihydrazide, >=98% (titration), CS-0010116, FT-0621914, EN300-03706, D72486, T 2210, Adipic acid dihydrazide, purum, >=97.0% (NT), A801603, J-660023, Q-200600, Q4682936, Z56812730, F1943-0024, Hexanedihydrazide, Adipic dihydrazide, Adipohydrazide, Adipyl hydrazide, Adipic acid dihydrazide, Adipyl hydrazide, Adipic acid dihyrazide, Hexanedioic acid, dihydrazide, 403, adipohydrazide, Hexanedioic Acid Dihydrazide, ADH, ADH (hydrazide), ADH 4S, ADH-J, ADH-S, Adipic dihydrazide, Adipoyl Dihydrazide, Adipoyl Hydrazide, Adipoyldihydrazine, Ajicure ADH, BK 1000Z, BT 1000Z, NSC 29542, NSC 3378, Qualimer ADH, T 2210, Adipohydrazide, Adipic dihydrazide, adipohydrazide, adipic acid dihydrazide, hexanedioic acid, dihydrazide, adipyl hydrazide, hexanediohydrazide, adipic acid, dihydrazide, adipodihydrazide, hexanedioic acid, 1,6-dihydrazide, unii-vk98i9yw5m, Hexanedioic acid,1,6-dihydrazide, Adipic acid dihydrazide, Hexanedioic acid,dihydrazide, Adipic dihydrazide, Adipoyl hydrazide, ADH, Adipoyl dihydrazide, Adipoyldihydrazine, Qualimer ADH, BT 1000Z, BK 1000Z, NSC 29542, NSC 3378, ADH 4S, ADH (hydrazide), ADH-J, ADH-S, T 2210, Ajicure ADH, Adipic acid dihydrazide, Technicure ADH, Epicure PD 797, 98152-55-7, 124246-54-4, ADH, Adipohydrazide, ADIPODIHYDRAZIDE, adipoyl hydrazide, Adipic dihydrazide, Adipic dihydrazide, ADIPINIC DIHYDRAZIDE, ADIPIC ACID DIHYDRIZIDE, ADIPIC ACID DIHYDRAZIDE

Hexanedihydrazide is a chemical used for cross-linking water-based emulsions.
Hexanedihydrazide is a symmetrical molecule with a C4 backbone and the reactive group is C=ONHNH2.

Hexanedihydrazide is a latent hardener for epoxy resin.
Dihydrazides are made by the reaction of an organic acid with hydrazine.
Other dihydrazides with different backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).

Hexanedihydrazide is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Hexanedihydrazide is an effective crosslinking agent, curative and hardener.

Hexanedihydrazide is the most common dihydrazide crosslinking agent within a series of dihydrazides such as sebacic dihydrazide (SDH) and isophthalic dihydrazide (IDH).
Hexanedihydrazide’s has a melting point of 180 °C and a molecular weight of 174; both are lower than the alternative dihydrazides SDH and IDH.

Hexanedihydrazide is a symmetrical molecule with a C4 backbone and the reactive group is C=ONHNH2.
Dihydrazides are made by the reaction of an organic acid with hydrazine.
Other dihydrazides with different backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).

The applications of Hexanedihydrazide are facilitated by the nucleophilicity of the amine function (good reaction characteristics), the good overall properties and weatherability of cured systems.
The moderate solubility of Hexanedihydrazide in water (50 g./liter) and common organic solvents facilitates the use of Hexanedihydrazide in aqueous and solvent based systems.

The cure temperature for epoxy resins (glycidyl types) formulated with Hexanedihydrazide is influenced by the melt-out temperature of the Hexanedihydrazide, which allows an extended pot life at low temperatures.
Storage stability can be up to six-months at room temperature, with cure times of about one-hour at 130 °C.

Cure rates can be accelerated using tin or titanate catalysts, or imidazoles.
One-component Hexanedihydrazide epoxy systems can be partially cured or “B-staged”, and later fully cured.
B-staging provides handling, processing, and fabrication advantages.

Hexanedihydrazide is a distinctive crosslinking agent and curative that provides controlled reactivity and performance improvements in epoxy resins, polyurethane dispersions (PUDs), solvent-based polyurethanes (PURs), and emulsion acrylic resins.
Hexanedihydrazide finds major applications as a latent curing agent for B-stageable epoxy resins and as an ambient temperature crosslinking agent for high-performance acrylic emulsion architectural coatings.
Materials crosslinked or cured with Hexanedihydrazide demonstrate excellent colour stability, weathering resistance, adhesion, durability, hardness, and toughness.

Hexanedihydrazide is a chemical used for cross-linking water-based emulsions.
Hexanedihydrazide can also be used as a hardener for certain epoxy resins.

Hexanedihydrazide is a symmetrical molecule with a C4 backbone, and the reactive group is C=ONHNH2.
Dihydrazides are made by the reaction of an organic acid with hydrazine.
Other dihydrazides with different backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).

Homobifunctional cross-linking reagent that is specific for aldehydes resulting in relatively stable hydrazone linkages.
This is commonly used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation.

Hexanedihydrazide acts as a reducing agent in organic synthesis.
Hexanedihydrazide reduces aldehydes and ketones to alcohols, and Hexanedihydrazide reduces nitro compounds to amines.
Hexanedihydrazide also acts as a catalyst in the production of polyurethane foams, and Hexanedihydrazide is used as a cross-linking agent in polymers.

Hexanedihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.
Hexanedihydrazide is also employed as a paint additive and coating additive.

Hexanedihydrazide is also used as an intermediate.
Further, Hexanedihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.

Hexanedihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes.
This results in relatively stable hydrazone linkages.

Hexanedihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation.
Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Hexanedihydrazide is the most suitable hydrazide cross-linking agent, and Hexanedihydrazide has been widely used in water-based paint emulsions in combination with diacetone acrylamide.
Hexanedihydrazide is weakly alkaline, and there is a possibility of agglomeration when solid Hexanedihydrazide is added directly to the emulsion, so usually Hexanedihydrazide should be dissolved in hot water before use.

Applications of Hexanedihydrazide:
Hexanedihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.
Hexanedihydrazide is also employed as a paint additive and coating additive.

Hexanedihydrazide is also used as an intermediate.
Further, Hexanedihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.

Hexanedihydrazide has been used:
Hexanedihydrazide is used in the preparation of reactive premix to synthesize the porous biomaterial.
Hexanedihydrazide is used for the crosslinking of methacrylated chondroitin sulfate (MA-CS) coating using carbodiimide-based chemistry for the production and characterization of methacrylated chondroitin sulfate magnetic nanoparticles (MA-CS MNPs).

Hexanedihydrazide is used for the covalent labeling of rhamnolipids, pyochelin, and vancomycin with Abberior STARNHS ester dye.
Hexanedihydrazide is used as a difunctional crosslinking agent in paints and coatings for certain water-based acrylic emulsions.

Hexanedihydrazide is used as a hardener for epoxy resins and a chain extender for polyurethanes.
A small use is as a formaldehyde scavenger preventing the liberation of formaldehyde.

Hexanedihydrazide is Applied in The Production of:
Crosslinking Agent for Polymers
Elastomers and Rubber Industry
Adhesives and Sealants
Coatings and Paints
Textile Industry
Corrosion Inhibitors
Biomedical Applications
Photography
Water Treatment
Fuel Additives
Polymer Modification

Uses of Hexanedihydrazide:
Hexanedihydrazide is used to functionalize magnetic nanoparticles for glycopeptide enrichment and identification.
Hexanedihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages.

Hexanedihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation.
Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Hexanedihydrazide can also be used as a chain extension for liquid rubber.
Hexanedihydrazide can also be used as a hardener for certain epoxy resins.

Hexanedihydrazide is used adhesives and sealant chemicals, and Automotive care products.
Hexanedihydrazide is used for epoxy powder coating curing agent and coating additives, Metal deactivator and other polymer additives and water treatment agent.

Hexanedihydrazide is the most suitable hydrazide crosslinking agent.
Hexanedihydrazide and diacetone acrylamide have been widely used in water-based paint emulsion.
Hexanedihydrazide is weakly alkaline, solid Hexanedihydrazide is directly added to the emulsion may produce coalescence, usually Hexanedihydrazide should be dissolved in hot water (poor solubility in cold water) and reused.

Hexanedihydrazide bifunctional compound, which can be cross-linked with sodium hyaluronate as a protein drug carrier.
Hexanedihydrazide plays a cross-linking role with diacetone acrylamide in the post-crosslinking of water emulsion and water-soluble polymer, such as water-based coatings, adhesives, fibers, plastic film treatment, hair spray, etc., and can also be used as epoxy powder coating curing agent And water-based coating additives, metal deactivators and other polymer additives and water treatment agents, indoor formaldehyde adsorbents and intermediate raw materials.

The same type of bifunctional linker for aldehydes can produce relatively stable hydrazone linkage; for the linkage of carbohydrate proteins, such as antibodies, periodate oxidation reaction occurs at a specific form of position; at pH 5.0, oxidation reaction and coupling reaction can be carried out conveniently, hydrazide derived from low pKa value can avoid competitive reaction through primary amine.

Hexanedihydrazide is mainly used for epoxy powder coating curing agent and coating additives, metal deactivator and other polymer additives and water treatment agents.
Hexanedihydrazide is used as a crosslinking agent in acrylic emulsion with ketone group.

Hexanedihydrazide is used in epoxy adhesives and sealants.
Hexanedihydrazide is used crosslinking agent for self crosslinking emulsion resins using DAAM.
Hexanedihydrazide, also known as ADH or Adipohydrazide, can be used as a hardener for epoxy resins and for cross-linking water-based emulsions.

Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Hexanedihydrazide is used analytical Reagents, Diagnostic Reagents, Teaching Reagents.

Hexanedihydrazide is used for Biological Purpose, For Tissue Medium Purpose, For Electron Microscopy, For Lens Blooming, Pro Analysis, Super Special Grade, For Scintillation, For Electrophoresis Use, For Refractive Index.
Hexanedihydrazide is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Hexanedihydrazide is used in the following products: coating products, adhesives and sealants, fillers, putties, plasters, modelling clay, finger paints, polymers, non-metal-surface treatment products, textile treatment products and dyes and washing & cleaning products.
The same bifunctional crosslinking reagent, Hexanedihydrazide, is specially used for aldehydes to generate relatively stable hydrazone links.

Other release to the environment of Hexanedihydrazide is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).
Other release to the environment of Hexanedihydrazide is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

Hexanedihydrazide can be found in complex articles, with no release intended: vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).
In particular, Hexanedihydrazide is used to connect glycoproteins, such as antibodies.

Hexanedihydrazide is used in the following products: adhesives and sealants, coating products, paper chemicals and dyes, textile treatment products and dyes and washing & cleaning products.
Hexanedihydrazide is used for the manufacture of: textile, leather or fur and wood and wood products.

Other release to the environment of Hexanedihydrazide is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Hexanedihydrazide is used in the following products: adhesives and sealants, coating products, fillers, putties, plasters, modelling clay, polymers, textile treatment products and dyes and finger paints.
Release to the environment of Hexanedihydrazide can occur from industrial use: formulation of mixtures and formulation in materials.

Hexanedihydrazide is used in the following products: paper chemicals and dyes, coating products, textile treatment products and dyes, adhesives and sealants, finger paints, laboratory chemicals, washing & cleaning products and water treatment chemicals.
Hexanedihydrazide is used for the manufacture of: chemicals, pulp, paper and paper products and plastic products.

Release to the environment of Hexanedihydrazide can occur from industrial use: for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles and as processing aid.
Release to the environment of Hexanedihydrazide can occur from industrial use: manufacturing of the substance.

Hexanedihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages.
Hexanedihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site-specific fashion following periodate oxidation.
Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Hexanedihydrazide is used to functionalize magnetic nanoparticles for gylcopeptitde enrichment and identification.
Hexanedihydrazide can also be used as a chain extension for liquid rubber.

Hexanedihydrazide is used for synthesis.
Hexanedihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.

Hexanedihydrazide is also employed as a paint additive and coating additive.
Hexanedihydrazide is also used as an intermediate.

Further, Hexanedihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.
Hexanedihydrazide is widely used as cross-linker in waterborne acrylic emulsions.

Hexanedihydrazide is added to the water phase in a PUD.
Crosslinking occurs during the drying and film coalescence process which is ideal for maximizing the film properties including gloss, scrub, stain and wear resistance and durability.

Other crosslinking methods where crosslinking occurs prior to film coalescence exhibit reduced performance properties including poor flow and leveling.
The full reactivity characteristics of Hexanedihydrazide are ideal for PUR systems.
Alternative curatives which show incomplete crosslinking due to slow reactivity and the lack of curative mobility in a dry film will also compromise performance.

The DAAM/Hexanedihydrazide pair is also used in crosslinkable sizing agents, thickeners, adhesives, and sealants.
Hexanedihydrazide is a unique crosslinking agent and curative, offering controlled reactivity and performance enhancements in epoxy resins, polyurethane dispersions (PUDs), solvent based PURs and emulsion acrylic resins.

The major applications for Hexanedihydrazide are a latent curing agent for B-stageable epoxy resins and an ambient temperature crosslinking agent for high performance acrylic emulsion architectural coatings.
Systems crosslinked or cured with Hexanedihydrazide exhibit good color stability and weathering characteristics, adhesion, durability, hardness, and toughness.

Hexanedihydrazide is a chemical used for cross-linking water-based emulsions.
Hexanedihydrazide can also be used as a hardener for certain epoxy resins.

Hexanedihydrazide is used as a difunctional crosslinking agent in paints and coatings for certain water-based acrylic emulsions.
Hexanedihydrazide is used as a hardener for epoxy resins and a chain extender for polyurethanes.

A small use is as a formaldehyde scavenger preventing the liberation of formaldehyde.
One component epoxy resins are used in coatings such as powder coatings, adhesives including hot melt adhesives, molding compounds and in fiber reinforced composites.

Glass and carbon fiber prepreg obtained by a hot melt impregnation method are used in the fabrication of sporting goods, wind turbine blades and aircraft/aerospace components.
With Hexanedihydrazide cure, epoxy resins exhibit excellent toughness, flexibility, and adhesive properties.

Tg’s of 140-160 °C are achievable using a standard liquid bisphenol A epoxy resin (DGEBA) with Hexanedihydrazide as the hardener.
Rigid and flexible epoxy adhesives have been formulated as one component systems that can be stored at room temperature using Hexanedihydrazide as a latent curing agent.
Rigid epoxy adhesives are based on bisphenol A and novolac epoxides.

These rigid adhesives exhibit excellent cohesive and adhesive properties to a wide variety of surfaces.
Flexible epoxy adhesives produce more pliable bonds which better accommodate bond line stresses or differential substrate expansion rates.

Flexible epoxy resins include aliphatic di- and tri-epoxy resins such as hexanediol diglycidyl ether and poly(oxypropylene) diglycidyl ethers.
Semi-rigid epoxy-based adhesives utilize mixtures of both classes of epoxy resins or rigid formulations using flexibilizers.

Epoxy Resins:
A notable fact with regard to Hexanedihydrazide in epoxy formulations is that each of the primary amine end groups has a functionality of two, so the Hexanedihydrazide molecule has an equivalency of four per epoxy moiety.
Accordingly, the active hydrogen equivalent weight of Hexanedihydrazide is 43.5.
When formulated with epoxy resins, the Hexanedihydrazide index can range between 0.85-1.15 of stoichiometric proportions, without a significant effect on mechanical properties.

Industry Uses:
Adhesion/cohesion promoter
Binder
Hardener
Other (specify)
Paint additives and coating additives not described by other categories
Plasticizer

Consumer Uses:
Hardener
Other
Other (specify)
Paint additives and coating additives not described by other categories

Biochem/physiol Actions of Hexanedihydrazide:
Hexanedihydrazide is a low molecular weight compound that comprises a hydrazide group at each end.
This leads to the supply of extra adsorption sites for heavy metals that maintain or elevate the adsorption capacities of the cross-linked adsorbents.
Hexanedihydrazide is used as a crosslinker in various fields, like making mechanical latexes films and injectable oxidized hyaluronic acid hydrogel.

General Manufacturing Information of Hexanedihydrazide:

Industry Processing Sectors:
Adhesive Manufacturing
Custom Compounding of Purchased Resins
Paint and Coating Manufacturing
Paper Manufacturing
Plastics Product Manufacturing
Printing Ink Manufacturing

Typical Properties of Hexanedihydrazide:
Hexanedihydrazide is physical and chemical properties appearance white crystalline powder
Hexanedihydrazide is soluble in water, slightly soluble in acetone, and acetic anhydride or acid chloride can occur acylation reaction, is an important amide hydrazine compounds.

Hexanedihydrazide serves as a difunctional crosslinking agent in paints and coatings applied to specific water-based acrylic emulsions.
Additionally, Hexanedihydrazide acts as a hardener for epoxy resins and a chain extender for polyurethanes.
Moreover, Hexanedihydrazide finds a minor application as a formaldehyde scavenger, preventing the release of formaldehyde.

Polyurethane Dispersions (Puds):
Hexanedihydrazideis an effective room temperature curative for aqueous PUDs and solution polyurethanes.
In this capacity, Hexanedihydrazide provides polyurea coatings with higher hardness, toughness and adhesion properties, excellent mechanical properties, abrasion and chemical resistance.
Hexanedihydrazide cured polyurethane coatings exhibit good color stability and weathering properties, which is not observed with standard amine curatives.

Handling And Storage of Hexanedihydrazide:

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage stability:

Recommended storage temperature:
20 °C

Stability And Reactivity of Hexanedihydrazide:

Chemical stability:
Hexanedihydrazide is chemically stable under standard ambient conditions (room temperature).

First Aid Measures of Hexanedihydrazide:

If inhaled:

After inhalation:
Fresh air.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.

In case of eye contact:

After eye contact:
Rinse out with plenty of water.
Remove contact lenses.

If swallowed:

After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.

Fire Fighting Measures of Hexanedihydrazide:

Extinguishing media:

Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

Accidental Release Measures of Hexanedihydrazide:

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.

Observe possible material restrictions:
Take up dry.

Dispose of properly.
Clean up affected area.

Exposure Controls/personal Protection of Hexanedihydrazide:

Personal protective equipment:

Eye/face protection:
Use equipment for eye protection.
Safety glasses.

Skin protection:

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

Control of environmental exposure:
Do not let product enter drains.

Identifiers of Hexanedihydrazide:
CAS number: 1071-93-8
EC number: 213-999-5
Hill Formula: C₆H₁₄N₄O₂
Molar Mass: 174.2 g/mol
HS Code: 2928 00 90
Flash point: 150 °C
Ignition temperature: 360 °C
Melting Point: 180 - 182 °C
Melting Point: 178.0°C to 182.0°C
Color: White to Yellow
Infrared Spectrum: Authentic
Assay Percent Range: 8%
Linear Formula: H2NNHCO(CH2)4CONHNH2
Beilstein: 02, I, 277
Solubility Information Solubility in water: soluble.
Other solubilities: soluble in acetic acid,slightly soluble in acetone,
insoluble in ethanol,ether and benzene
Formula Weight: 174.2
Percent Purity: 98%
Physical Form: Crystalline Powder

Molecular Weight: 174.20100
Exact Mass: 174.20
EC Number: 213-999-5
UNII: VK98I9YW5M
NSC Number: 29542|3378
DSSTox ID: DTXSID0044361
HScode: 2928000090
PSA: 110.24000
XLogP3: -2.1
Appearance: DryPowder
Density: 1.186 g/cm3
Melting Point: 171 °C @ Solvent: Water
Boiling Point: 519.3ºC at 760 mmHg
Flash Point: > 109ºC
Refractive Index: 1.513
Water Solubility: H2O: soluble
Storage Conditions: -20ºC
Vapor Pressure: 6.92E-11mmHg at 25°C

Properties of Hexanedihydrazide:
Molecular Weight: 174.20 g/mol
XLogP3-AA: -2.1
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 174.11167570 g/mol
Monoisotopic Mass: 174.11167570 g/mol
Topological Polar Surface Area: 110Ų
Heavy Atom Count: 12
Complexity: 142
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Physical state: powder
Color: white
Odor: No data available
Melting point/freezing point
Melting point/range: 180 - 182 °C - lit.
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 150 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 102 g/l at 20 °C - soluble
Partition coefficient:
n-octanol/water:
log Pow: -2,7 at 20 °C

Vapor pressure: No data available
Density: No data available
Relative density: 1,29 at 20 °C
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Molecular Formula: C6H14N4O2
Molar Mass: 174.2
Density: 1.186g/cm3
Melting Point: 175-182℃
Boling Point: 519.3°C at 760 mmHg
Flash Point: 267.9°C
Water Solubility: soluble
Vapor Presure: 6.92E-11mmHg at 25°C
Appearance: White crystal

Storage Condition: 2-8℃
Sensitive: Sensitive to air
Refractive Index: 1.513
MDL: MFCD00007614
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 519.30 °C. @ 760.00 mm Hg (est)
Flash Point: 514.00 °F. TCC ( 267.90 °C. ) (est)
logP (o/w): -2.670 (est)
Soluble in: water, 3.287e+005 mg/L @ 25 °C (est)
Appearance (Colour): White to pale yellow
Appearance (Form): Powder
Solubility: (Turbidity) 10% aq. solution: Clear
Solubility: (Colour) 10% aq. solution: Colourless to pale yellow
Assay (NT): min. 95.0%
Melting Point: 178 - 182°C
Loss on drying: max. 0.5%

CAS Number: 1071-93-8
Abbreviations: ADH
Beilstein Reference: 973863
ChemSpider: 59505
ECHA InfoCard: 100.012.727
EC Number: 213-999-5
MeSH: Adipic+dihydrazide
PubChem CID: 66117
RTECS number: AV1400000
UNII: VK98I9YW5M
CompTox Dashboard (EPA): DTXSID0044361
InChI: InChI=1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
Key: IBVAQQYNSHJXBV-UHFFFAOYSA-N
InChI=1/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
Key: IBVAQQYNSHJXBV-UHFFFAOYAB
SMILES: O=C(NN)CCCCC(=O)NN

Specifications of Hexanedihydrazide:
Color according to Munsell color system: not more intensely colored than reference standard NE12
Assay (HClO₄): ≥ 97.0 %
Melting range (lower value): ≥ 178 °C
Melting range (upper value): ≤ 182 °C
Identity (IR): passes test

Melting Point: 180 - 183 Deg C:
Fe: <0.0005%:
Loss on Drying: <0.5%:
Sulfate: <0.005%:
Assay: >99%:
Methanol: <0.1%:
Non Volatile Matter: <0.01%:
Cl: <0.005%:
Appearance: White crystalline powder:
Hydrazine: <20ppm

Related compounds of Hexanedihydrazide:
hexanedioic acid
Adipic dihydrazide
hexanedioyl dichloride
hexanedinitrile
hexanediamide

Names of Hexanedihydrazide:

Preferred IUPAC name:
Adipic dihydrazide

Other names:
Hexanedihydrazide
Adipohydrazide
Adipyl hydrazide

Hexane-1,6-diol is prepared by the hydrogenation of adipic acid or its esters.
Laboratory preparation could be achieved by reduction of adipates with lithium aluminium hydride, although this method is impractical on a commercial scale.
Hexane-1,6-diol is an organic compound with the formula (CH2CH2CH2OH)2.

CAS: 629-11-8
MF: C6H14O2
MW: 118.17
EINECS: 211-074-0

Hexane-1,6-diol is a colorless water-soluble solid.
Hexane-1,6-diol is a no-irritating to the skin. However, it can be irritative to the respiratory tract and mucous membrane.
Hexane-1,6-diol vapours or dust cause irritation to the eye. Severe eye exposure may cause conjunctivitis, iritis, and diffuse corneal opacity.
A diol that is hexane substituted by hydroxy groups at positions 1 and 6.
Hexane-1,6-diol is a diol compound that has gained significant attention in the scientific community due to its unique properties and potential applications.
Hexane-1,6-diol is a colorless liquid that is soluble in water and organic solvents, and it has a wide range of industrial and scientific applications.

Hexane-1,6-diol Chemical Properties
Melting point: 38-42 °C (lit.)
Boiling point: 250 °C (lit.)
Density: 0.96
Vapor pressure: 0.53 mm Hg ( 20 °C)
Refractive index: 1.457
Fp: 215 °F
Storage temp.: Store below +30°C.
Solubility H2O: 0.1 g/mL, clear, colorless
Form: Waxy Flakes
pka: 14.87±0.10(Predicted)
Color: White
PH: 7.6 (900g/l, H2O, 20℃)
Explosive limit: 6.6-16%(V)
Water Solubility: 500 g/L
Sensitive: Hygroscopic
λmax λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Merck: 14,4690
BRN: 1633461
InChIKey: XXMIOPMDWAUFGU-UHFFFAOYSA-N
LogP: 0 at 25℃
CAS DataBase Reference: 629-11-8(CAS DataBase Reference)
NIST Chemistry Reference: Hexane-1,6-diol (629-11-8)
EPA Substance Registry System: Hexane-1,6-diol (629-11-8)

Uses
Hexane-1,6-diol is widely used for industrial polyester and polyurethane production.
Hexane-1,6-diol can improve the hardness and flexibility of polyesters as it contains a fairly long hydrocarbon chain.
In polyurethanes, Hexane-1,6-diol is used as a chain extender, and the resulting modified polyurethane has high resistance to hydrolysis as well as mechanical strength, but with a low glass transition temperature.
Hexane-1,6-diol is also an intermediate to acrylics as a crosslinking agent, e.g. hexanediol diacrylate.
Unsaturated polyester resins have also been made from Hexane-1,6-diol, along with styrene, maleic anhydride and fumaric acid.
Hexane-1,6-diol is used in polymer synthesis such as polyester, polyurethane and nylon.
Hexane-1,6-diol is used as an intermediate to adhesives, acrylics and dyestuffs.
Further, Hexane-1,6-diol is employed in gasoline refining and pharmaceutical production.

Polyurethanes
Hexane-1,6-diol is widely utilized in the manufacture of polyesterols such as sebacates, azelates, and adipates.
Hexane-1,6-diol are resistant to hydrolysis and have low glass transition temperature as well as high mechanical levels.
Hexane-1,6-diol is used as an ingredient in the preparation of a wide range of tailor-made products for numerous specialty and standard applications.

In Acrylics
Hexane-1,6-diol is utilized as an ingredient in the manufacture of the bifunctional hexanediol diacrylate which is a monomer that is normally used in conjunction with other acrylic monomers as a reactive diluent for decorative coatings and printing inks.

In Adhesives
Urethanes and co-terephthalates that are based on Hexane-1,6-diol provide faster better tack properties and crystallization.
Due to its low glass transition property, Hexane-1,6-diol offers high flexibility as well as excellent adhesive properties.

Other Uses
Hexane-1,6-diol is incorporated into the production of other compounds used in polymeric thickeners, sizing agents, plasticizers for polyvinyl chloride, pesticides, and surfactants dyestuffs as a flexible building block.

Quality and Analysis
The assay of the pure product is about 98 %; impurities are various diols and -caprolactone as well as traces of water.
The color number of the product determined photometrically according to the Pt/Co scale must not exceed 15 APHA.
Above 70 ℃, Hexane-1,6-diol tends to turn yellow.

Synonyms
1,6-HEXANEDIOL
Hexane-1,6-diol
629-11-8
Hexamethylene glycol
1,6-Dihydroxyhexane
Hexamethylenediol
alpha,omega-Hexanediol
.alpha.,.omega.-Hexanediol
1,6-Hexylene Glycol
6-hydroxy-1-hexanol
DTXSID1027265
CHEBI:43078
NSC-508
ZIA319275I
1,1,6,6-D4-1,6-HEXANDIOL
27236-13-1
HEZ
CCRIS 8982
HSDB 6488
NSC 508
EINECS 211-074-0
BRN 1633461
UNII-ZIA319275I
AI3-03307
1,6hexanediol
1.6-hexanediol
1,6-hexandiol
1.6-hexandiol
.omega.-Hexanediol
1,6-hexane diol
1,6-hexan-diol
hexan-1,6-diol
Hexanediol-(1,6)
HEXANEDIOL [INCI]
1,6-Hexanediol, 97%
1,6-Hexanediol, 99%
EC 211-074-0
WLN: Q6Q
HO(CH2)6OH
SCHEMBL15343
CHEMBL458616
DTXCID907265
NSC508
1,6-HEXANEDIOL [HSDB]
HEXAMETHYLENE GLYCOL [MI]
Tox21_200450
MFCD00002985
AKOS003242194
CS-W011221
DB02210
NCGC00248624-01
NCGC00258004-01
AS-12686
BP-21412
CAS-629-11-8
FT-0607014
H0099
EN300-19325
1,6-Hexanediol, >=99% C6-Dioles basis (GC)
A834086
Q161563
J-504039
F0001-1701
Z104473540
InChI=1/C6H14O2/c7-5-3-1-2-4-6-8/h7-8H,1-6H

Hexanedioic acid also known as Adipic acid is a dibasic acid with the molecular formula C3H8O4, CAS 124-04-9.
Hexanedioic acid is slightly soluble in water and soluble in alcohol and acetone.
Hexanedioic acid is the most important dicarboxylic acid with roughly 2.5 billion kilograms produced annually and mainly used as a precursor to nylon production.

CAS Number: 124-04-9
EC Number: 204-673-3
Molecular Formula: C6H10O4
Molar Mass: 146.14 g/mol

Hexanedioic Acid, also known as Adipic acid, is a dicarboxylic acid.
Hexanedioic acid is an intermediate for nylon and a precursor in the synthesis of polyester polyols for polyurethane systems and thermoplastic polyurethanes.
Hexanedioic acid is colorless crystalline powder.

Hexanedioic acid is an organic dicarboxylic acid.
Available in various quantities, Hexanedioic acid is used as a monomer in nylon production.
Other applications include use as a monomer for polyurethane production, a component of controlled-release drugs, and a food additive.

Hexanedioic acid, solid white powder, is a very important organic compound for today chemical industry.
Hexanedioic acid (AA), CAS number is 124-04-9, is a dicarboxylic acid with the formula: (CH2)4(COOH)2; for the chemical point of view, 1,6 Hexanedioic acid.

The main Hexanedioic acid application is the production of nylon by a polycondensation reaction.
Nylons are produced by the reaction of bifunctional monomers containing equal parts of amine and carboxylic acid.
Besides the production of Nylon 6,6 as well as specialty nylon grades, Hexanedioic acid, CAS 124-04-9, finds many other applications, like polyester polyols for polyurethanes (PU), manufacturing of resins for paper products, unsaturated polyester resins, adipates production, plasticizers for PVC and a small share of the market is ingredient for food and medication.

90% of Hexanedioic acid is consumed in the industry for the production of nylon by poly-condensation with hexamethylenediamine.
Hexanedioic acid is mainly used for the production of nylon 6,6 polymer for fibers and plastics.

Nylon has a protein-like structure.
Hexanedioic acid can be further processed into the fibers for applications in carpets (felts), automobile tire cords and clothing.

Hexanedioic acid can be used in the production of Hexanedioic acid plasticizer and lubricant components.
Hexanedioic acid can be used in the production of polyester polyols for polyurethane systems.

Technical grade Hexanedioic acid can be used to produce plasticizers, to add flexibility and to give flexibility to unsaturated polyesters.
Hexanedioic acid can be used in the production of rigid and flexible foams, in the production of wire coaters, elastomers and adhesives, to increase the flexibility of alkyd resins, in the production of wet strong resins and in the production of synthetic lubricants and oils for the paper chemical industry.

Hexanedioic acid, mol wt 146.14, HOOCCH2CH2CH,CH2COOH, is a white crystalline solid with a melting point of about 152°C.
Little of this dicarboxylic acid occurs naturally, but Hexanedioic acid is produced on a very large scale at several locations around the world.

The majority of this material is used in the manufacture of Nylon-6,6 polyamide, which is prepared by reaction with 1,6-hexanediamine.
Hexanedioic acid is a colorless, odorless, sour-tasting crystalline solid that undergoes reactions including esterification, amidation, reduction, halogenation, salt formation, and dehydration.

Hexanedioic acid also undergoes several industrially significant polymerization reactions.
Hexanedioic acid historically has been manufactured predominantly from cyclohexane.
However, much research continues to be directed to alternative feedstocks, especially butadiene and cyclohexene, as dictated by shifts in hydrocarbon pricing.

Air quality regulations may exert further pressure for alternative routes as manufacturers seek to avoid NOx abatement costs.
When dispersed as a dust, Hexanedioic acid is subject to normal dust explosion hazards.

The material is an irritant, especially upon contact with the mucous membranes.
Protective goggles or face shields should be worn when handling the material.

The material should be stored in corrosion-resistant containers, away from alkaline or strong oxidizing materials.
Hexanedioic acid is a very large-volume organic chemical and is one of the top 50 chemicals produced in the United States in terms of volume, although demand is highly cyclic.

Hexanedioic acid for nylon takes ∼60% of U.S. cyclohexane production.
Hexanedioic acid is relatively nontoxic.

Hexanedioic acid is an important inudstrial dicarboxylic acid with about 2.5 billion kilograms produced per year.
Hexanedioic acid is used mainly in the production of nylon.
Hexanedioic acid occurs relatively rarely in nature.

Hexanedioic acid has a tart taste and is also used as an additive and gelling agent in jello or gelatins.
Hexanedioic acid is also used in some calcium carbonate antacids to make them tart.

Hexanedioic acid has also been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basic and weakly acidic drugs.
Hexanedioic acid in the urine and in the blood is typically exogenous in origin and is a good biomarker of jello consumption.

In fact, a condition known as Hexanedioic aciduria is actually an artifact of jello consumption.
However, certain disorders (such as diabetes and glutaric aciduria type I.) can lead to elevated levels of Hexanedioic acid snd other dicarboxcylic acids (such as suberic acid) in urine.

Moreover, Hexanedioic acid is also found to be associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.
Hexanedioic acid is also microbial metabolite found in Escherichia.

Hexanedioic acid or hexanedioic acid is the organic compound with the formula (CH2)4(COOH)2.
From an industrial perspective, Hexanedioic acid is the most important dicarboxylic acid: about 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon.

Hexanedioic acid otherwise rarely occurs in nature, but Hexanedioic acid is known as manufactured E number food additive E355.
Salts and esters of Hexanedioic acid are known as adipates.

Hexanedioic acid is a white crystalline solid.
Hexanedioic acid is insoluble in water.

The primary hazard is the threat to the environment.
Immediate steps should be taken to limit Hexanedioic acid spread to the environment.
Hexanedioic acid is used to make plastics and foams and for other uses.

Hexanedioic acid is a straight-chain aliphatic dicarboxylic acid, commonly used in the manufacturing of nylon-6,6 and plasticizers.
Conventionally Hexanedioic acid was manufactured from petrochemicals but in recent days Hexanedioic acid can be synthesized from renewable substrates by means of biological methods.

Hexanedioic acid, or more formally hexanedioic acid, is a white crystalline solid that melts at 152 ºC.
Hexanedioic acid is one of the most important monomers in the polymer industry.

Hexanedioic acid is found in beet juice, but the article of commerce—≈2.5 million tonnes of Hexanedioic acid per year—is manufactured.
In 1906, French chemists L. Bouveault and R. Locquin reported that Hexanedioic acid can be produced by oxidizing cyclohexanol.
Today, the most common manufacturing process is the nitric acid (HNO3) oxidation of a cyclohexanol–cyclohexanone mixture called KA (for ketone–alcohol) oil.

Almost all Hexanedioic acid is used as a comonomer with hexamethylenediamine to produce nylon 6-6.
Hexanedioic acid is also used to manufacture other polymers such as polyurethanes.

Using HNO3 to produce Hexanedioic acid has its downside: Copious amounts of nitrous oxide (N2O), a greenhouse gas, are coproduced and released into the atmosphere.
In late 2014, K. C. Hwang and A. Sagadevan of National Tsing Hua University (Hsinchu City, Taiwan) reported a process that uses ozone and ultraviolet (UV) light to oxidize KA oil to Hexanedioic acid.

This method eliminates the production of N2O.
But before the process can be used commercially, problems associated with the formation of organic peroxides from ozone and the difficulty of using UV light on a large scale must be overcome.

Applications of Hexanedioic acid:
Hexanedioic acid is used to make nylon, polyurethane foams, lubricants, and plasticizers.
Hexanedioic acid is used in adhesives, baking powder, and food flavoring.

The major markets for Hexanedioic acid include use as feedstocks for nylon 6,6 resins and fibers, polyester polyols and plasticzers.
Documented applications for Hexanedioic acid are as a lubricant additive in coatings and foams and shoe soles, as a tanning agent in the leather industry, as a pH regulator in processes such as the manufacture of cleaning agents, as a pelletizing agent in disinfectant pills for drinking water, as an additive in flue gas sulphation, in dishwasher tablets.

Hexanedioic acid is used as an additive in coating and chemicals.
Hexanedioic acid is used as an acidulant in dry powdered food mixtures, especially in those products having delicate flavors & where addition of a tang to the flavor is undesirable.

Hexanedioic acid addition to foods imparts a smooth, tart taste.
In grape-flavored products, Hexanedioic acid adds a lingering supplementary flavor and gives an excellent set to food powders containing gelatin.

For concentrations of Hexanedioic acid ranging from 0.5-2.4 g/100 mL, the pH varies less than half a unit.
pH is low enough to inhibit browning of most fruits and other foodstuffs.

Hexanedioic acid can be used as a starting material in the preparation of:
Aliphatic polyesters by reacting with ethyleneglycol/1,3 propyleneglycol/1,4-butanediol using inorganic acid as a catalyst.
Cyclopentanone using a weak base such as Na2CO3.
Linear polybutylene adipate (PBA) having carboxylic acids at the terminals by reacting with 1,4-butanediol.

Uses of Hexanedioic acid:
More than 92% of the production of Hexanedioic acid is dedicated for the production of nylon 6,6 by a reaction with HMD Hexamethylene diamine.
Hexanedioic acid is used in nylon is utilized in fibbers, clothing, plastics, filaments, food packaging.

Hexanedioic acid is also used in polyurethane resins, foam, shoe soles, and as food additive.
Esters of Hexanedioic acid are used as plasticizers for PVC (Polyvinyl Chloride) resins and lubricant component.

Hexanedioic acid is one of the largest chemical distributor in Europe.
Hexanedioic acid is handling the storage, transport, export & import formalities of Hexanedioic acid globally.

About 60% of the 2.5 billion kg of Hexanedioic acid produced annually is used as monomer for the production of nylon by a polycondensation reaction with hexamethylene diamine forming nylon 66.
Other major applications also involve polymers; Hexanedioic acid is a monomer for production of polyurethane and Hexanedioic acid esters are plasticizers, especially in PVC.

In medicine:
Hexanedioic acid has been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basic and weakly acidic drugs.
Hexanedioic acid has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of a hydrophilic drug.

The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when Hexanedioic acid was used as a pore-forming agent without affecting release in the acidic media.
Other controlled-release formulations have included Hexanedioic acid with the intention of obtaining a late-burst release profile.

In foods:
Small but significant amounts of Hexanedioic acid are used as a food ingredient as a flavorant and gelling aid.
Hexanedioic acid is used in some calcium carbonate antacids to make them tart.

As an acidulant in baking powders, Hexanedioic acid avoids the undesirable hygroscopic properties of tartaric acid.
Hexanedioic acid, rare in nature, does occur naturally in beets, but this is not an economical source for commerce compared to industrial synthesis.

Other Uses of Hexanedioic acid:
Alcoholic beverages,
Baked goods,
Condiments,
Relishes,
Fats,
Oils,
Gelatins,
Pudding,
Gravies,
Imitation dairy,
Instant coffee,
Tea,
Meat products,
Nonalcoholic beverages,
Poultry,
Snack foods,
Adhesives and Sealants,
Alkyd resins,
Beamhouse,
Carrier for fragances,
Coal,
Crop Protection,
Environment protection,
Gas desulphurization,
Hardener and crosslinking agents for polymeres,
Manufacturing of coating,
Manufacturing of dyestuffs,
Manufacturing of fibres,
Manufacturing of herbicides,
Manufacturing of pharmaceutical agents,
Manufacturing of photochemicals,
Manufacturing of plastics,
Manufacturing of tensides,
Manufacturing of textile dyestuffs,
Manufacturing of textiles dyestuffs,
Paper Manufacture,
Plasticizers for polymeres,
Polyester,
Polyester resins,
Polymer auxiliaries,
Soaking,
Synthetic lubricants,
Textile dyestuffs.

Production of Hexanedioic acid:
Hexanedioic acid is white, crystalline compound mainly obtained by oxidation of cyclohexanol and cyclohexanone with nitric acid.
An alternative method of production of Hexanedioic acid is the hydrocarbonylation of butadiene, oxidation cleavage of cyclohexene.

Manufacturing Methods of Hexanedioic acid:
Commercially important processes employ two major reaction stages.
The first reaction stage is the production of the intermediates cyclohexanone and cyclohexanol, usually abbreviated as KA, KA oil, ol-one, or anone-anol.
The KA (ketone, alcohol), after separation from unreacted cyclohexane (which is recycled) and reaction by-products, is then converted to Hexanedioic acid by oxidation with nitric acid.

Cyclohexane is produced by the oxidation of cyclohexanol or cyclohexanone with air or nitric acid.

Preparation and Reactivity of Hexanedioic acid:
Hexanedioic acid is produced from a mixture of cyclohexanone and cyclohexanol called KA oil, the abbreviation of ketone-alcohol oil.
The KA oil is oxidized with nitric acid to give Hexanedioic acid, via a multistep pathway.

Early in the reaction, the cyclohexanol is converted to the ketone, releasing nitrous acid:
HOC6H11 + HNO3 → OC(CH2)5 + HNO2 + H2O

Among Hexanedioic acid many reactions, the cyclohexanone is nitrosated, setting the stage for the scission of the C-C bond:
HNO2 + HNO3 → NO+NO3− + H2O
OC6H10 + NO+ → OC6H9-2-NO + H+

Side products of the method include glutaric and succinic acids.
Nitrous oxide is produced in about one to one mole ratio to the Hexanedioic acid, as well, via the intermediacy of a nitrolic acid.

Related processes start from cyclohexanol, which is obtained from the hydrogenation of phenol.

Alternative methods of production:
Several methods have been developed by carbonylation of butadiene.

For example, the hydrocarboxylation proceeds as follows:
CH2=CH−CH=CH2 + 2 CO + 2 H2O → HO2C(CH2)4CO2H

Another method is oxidative cleavage of cyclohexene using hydrogen peroxide.
The waste product is water.

Historically, Hexanedioic acid was prepared by oxidation of various fats, thus the name (ultimately from Latin adeps, adipis – "animal fat"; cf. adipose tissue).

Reactions:
Hexanedioic acid is a dibasic acid (Hexanedioic acid has two acidic groups).
The pKa values for their successive deprotonations are 4.41 and 5.41.

With the carboxylate groups separated by four methylene groups, Hexanedioic acid is suited for intramolecular condensation reactions.
Upon treatment with barium hydroxide at elevated temperatures, Hexanedioic acid undergoes ketonization to give cyclopentanone.

Environmental of Hexanedioic acid:
The production of Hexanedioic acid is linked to emissions of N2O, a potent greenhouse gas and cause of stratospheric ozone depletion.

At Hexanedioic acid producers DuPont and Rhodia (now Invista and Solvay, respectively), processes have been implemented to catalytically convert the nitrous oxide to innocuous products:
2 N2O → 2 N2 + O2

Adipate salts and esters:
The anionic (HO2C(CH2)4CO2−) and dianionic (−O2C(CH2)4CO2−) forms of Hexanedioic acid are referred to as adipates.
An adipate compound is a carboxylate salt or ester of the acid.

Some adipate salts are used as acidity regulators, including:
Sodium adipate (E number E356)
Potassium adipate (E357)

Some adipate esters are used as plasticizers, including:
Bis(2-ethylhexyl) adipate
Dioctyl adipate
Dimethyl adipate

Human Metabolite Information of Hexanedioic acid:

Tissue Locations:
Kidney
Liver

Handling and Storage of Hexanedioic acid:

Nonfire Spill Response:
Do not touch or walk through spilled material.
Stop leak if you can do Hexanedioic acid without risk.

Prevent dust cloud.
For Asbestos, avoid inhalation of dust.

Cover spill with plastic sheet or tarp to minimize spreading.
Do not clean up or dispose of, except under supervision of a specialist.

SMALL DRY SPILL:
With clean shovel, place material into clean, dry container and cover loosely.
Move containers from spill area.

SMALL SPILL:
Pick up with sand or other non-combustible absorbent material and place into containers for later disposal.

LARGE SPILL:
Dike far ahead of liquid spill for later disposal.
Cover powder spill with plastic sheet or tarp to minimize spreading.
Prevent entry into waterways, sewers, basements or confined areas.

Storage Conditions of Hexanedioic acid:

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.

Storage class (TRGS 510):
Non Combustible Solids.

Safety of Hexanedioic acid:
Hexanedioic acid, like most carboxylic acids, is a mild skin irritant.
Hexanedioic acid is mildly toxic, with a median lethal dose of 3600 mg/kg for oral ingestion by rats.

First Aid Measures of Hexanedioic acid:

General notes:
Take off contaminated clothing.

Following inhalation:
Provide fresh air.
In all cases of doubt, or when symptoms persist, seek medical advice.

Following skin contact:
Rinse skin with water/shower.
In all cases of doubt, or when symptoms persist, seek medical advice.

Following eye contact:
Irrigate copiously with clean, fresh water for at least 10 minutes, holding the eyelids apart.
In case of eye irritation consult an ophthalmologist.

Following ingestion:
Rinse mouth.
Call a doctor if you feel unwell.

INHALATION:
Remove victim to fresh air.
Get medical attention if irritation persists.

EYES:
Flush with water for at least 15 min.

SKIN:
Flush with water.

Fire Fighting of Hexanedioic acid:

SMALL FIRE:
Dry chemical, CO2, water spray or regular foam.

LARGE FIRE:
Water spray, fog or regular foam.
Do not scatter spilled material with high-pressure water streams.

If Hexanedioic acid can be done safely, move undamaged containers away from the area around the fire.
Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS:
Cool containers with flooding quantities of water until well after fire is out.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

Fire Fighting Procedures of Hexanedioic acid:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Wear self-contained breathing apparatus for firefighting if necessary.

Stop discharge if possible, keep people away.
Shut off ignition sources.

Call fire department.
Avoid contact with solid and dust.
Isolate and remove discharged material.

If material on fire or involved in fire:
Use water in flooding quantities as fog.
Solid streams of water may spread fire.

Cool all affected containers with flooding quantities of water.
Apply water from as far a distance as possible.
Use foam, dry chemical, or carbon dioxide.

Accidental Release Measures of Hexanedioic acid:

Isolation and Evacuation:

IMMEDIATE PRECAUTIONARY MEASURE:
Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL:
Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE:
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions.
Also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Spillage Disposal of Hexanedioic acid:
Sweep spilled substance into covered plastic containers.
If appropriate, moisten first to prevent dusting.
Wash away remainder with plenty of water.

Cleanup Methods of Hexanedioic acid:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid dust formation.

Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Evacuate personnel to safe areas.
Avoid breathing dust.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Environmental considerations- land spill:
Dig a pit, pond, lagoon, or holding area to contain liquid or solid material.
If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner.
Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Environmental considerations- water spill:
Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom.
If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount.

Remove trapped material with suction hoses.
Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Electrochemical measurements have been made on the system Cu(2+), Hexanedioic acid, nitric acid (which models the effluent from Hexanedioic acid plants) to investigate the reasons for the observed low current efficiency for copper deposition from such soln.
The most probable cause is a cathodic shift in the deposition potential of copper making the reduction of NO3- the preferred process.

Depletion experiments have been carried out on real effluent in two three-dimensional cells, a bipolar trickle tower and a porous reticulated carbon bed.
Each performs reasonably well and, while the current efficiencies are low (about 20%), the deposition is essentially mass-transfer controlled.

Neutralizing agents for acids and caustics:
Rinse with dilute soda ash solution.

Identifiers of Hexanedioic acid:
CAS Number: 124-04-9
Beilstein Reference: 1209788
ChEBI: CHEBI:30832
ChEMBL: ChEMBL1157
ChemSpider: 191
ECHA InfoCard: 100.004.250
EC Number: 204-673-3
E number: E355 (antioxidants, ...)
Gmelin Reference: 3166
KEGG: D08839
PubChem CID: 196
RTECS number: AU8400000
UNII: 76A0JE0FKJ
UN number: 3077
CompTox Dashboard (EPA): DTXSID7021605

InChI:
InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
Key: WNLRTRBMVRJNCN-UHFFFAOYSA-N
InChI=1/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
Key: WNLRTRBMVRJNCN-UHFFFAOYAY

SMILES:
O=C(O)CCCCC(=O)O
C(CCC(=O)O)CC(=O)O

CAS number: 124-04-9
EC index number: 607-144-00-9
EC number: 204-673-3
Hill Formula: C₆H₁₀O₄
Molar Mass: 146.14 g/mol
HS Code: 2917 12 00

CAS Number: 124-04-9
Molecular Weight: 146.14
Beilstein: 1209788
EC Number: 204-673-3
MDL number: MFCD00004420
eCl@ss: 39021711
PubChem Substance ID: 57653836
NACRES: NA.21

CAS: 124-04-9
Molecular Formula: C6H10O4
Molecular Weight (g/mol): 146.142
MDL Number: MFCD00004420
InChI Key: WNLRTRBMVRJNCN-UHFFFAOYSA-N
PubChem CID: 196
ChEBI: CHEBI:30832
IUPAC Name: hexanedioic acid
SMILES: C(CCC(=O)O)CC(=O)O

Properties of Hexanedioic acid:
Chemical formula: C6H10O4
Molar mass: 146.142 g·mol−1
Appearance: White crystals[1]
Monoclinic prisms[2]
Odor: Odorless
Density: 1.360 g/cm3
Melting point: 152.1 °C (305.8 °F; 425.2 K)
Boiling point: 337.5 °C (639.5 °F; 610.6 K)
Solubility in water: 14 g/L (10 °C)
24 g/L (25 °C)
1600 g/L (100 °C)
Solubility: Very soluble in methanol, ethanol
soluble in acetone, acetic acid
slightly soluble in cyclohexane
negligible in benzene, petroleum ether
log P: 0.08
Vapor pressure: 0.097 hPa (18.5 °C) = 0.073 mmHg
Acidity (pKa): 4.43, 5.41
Conjugate base: Adipate
Viscosity: 4.54 cP (160 °C)

Density: 1.36 g/cm3 (25 °C)
Flash point: 196 °C
Ignition temperature: 405 °C
Melting Point: 150.85 °C
pH value: 2.7 (23 g/l, H₂O, 25 °C)
Vapor pressure: 0.097 hPa (18.5 °C)
Bulk density: 700 kg/m3
Solubility: 15 g/l

General Properties: White, solid crystals
Odor: Odorless
Intensity: 1.360 g/cm3
Boiling point: 337,5°C
Melting point: 152,1 °C
Flash point: 196°C
Vapor pressure: 0,0073 mmHg (18,5 °C)
Refraction index: –
Solubility (aquenous): 14g/L (10°C), 1600 g/L (100°C)

Vapor density: 5 (vs air)
Quality Level: 200
Vapor pressure: 1 mmHg ( 159.5 °C)
Assay: 99%
Form: crystals
Autoignition temp.: 788 °F
bp: 265 °C/100 mmHg (lit.)
mp: 151-154 °C (lit.)
Solubility: H2O: soluble 23 g/L at 25 °C
SMILES string: OC(=O)CCCCC(O)=O
InChI: 1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
InChI key: WNLRTRBMVRJNCN-UHFFFAOYSA-N

Molecular Weight: 146.14
XLogP3: 0.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 146.05790880
Monoisotopic Mass: 146.05790880
Topological Polar Surface Area: 74.6 Ų
Heavy Atom Count: 10
Complexity: 114
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Hexanedioic acid:
Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 150 °C
Melting range (upper value): ≤ 154 °C
Identity (IR): passes test

Melting Point: 151.0°C to 153.0°C
Boiling Point: 337.0°C
CAS Min %: 98.5
CAS Max %: 100.0
Color: White
Assay Percent Range: 99%
Linear Formula: HO2C(CH2)4CO2H
Beilstein: 02, 649
Fieser: 01,15
Merck Index: 15, 150
Formula Weight: 146.14
Percent Purity: 99%
Quantity: 500 g
Flash Point: 196°C
Infrared Spectrum: Authentic
Packaging: Plastic bottle
Physical Form: Crystalline Powder
Chemical Name or Material: Hexanedioic acid

Structure of Hexanedioic acid:
Crystal structure: Monoclinic

Thermochemistry of Hexanedioic acid:
Std enthalpy of formation (ΔfH⦵298): −994.3 kJ/mol[3

Related Products of Hexanedioic acid:
Hydroxynorketamine-d6 Hydrochloride
(S)-Ketamine-d6 Hydrochloride
Norketamine-d4
S-(-)-Norketamine-d6 Hydrochloride
Phencyclidine-d5 Hydrochloride

Related compounds of Hexanedioic acid:

Related dicarboxylic acids:
glutaric acid
pimelic acid

Related compounds:
hexanoic acid
adipic acid dihydrazide
hexanedioyl dichloride
hexanedinitrile
hexanediamide

Names of Hexanedioic acid:

Preferred IUPAC name:
Hexanedioic acid

Other names:
Adipic acid
Butane-1,4-dicarboxylic acid
Hexane-1,6-dioic acid
1,4-butanedicarboxylic acid

Synonyms of Hexanedioic acid:
adipic acid
hexanedioic acid
124-04-9
Adipinic acid
1,4-Butanedicarboxylic acid
Adilactetten
Acifloctin
Acinetten
1,6-Hexanedioic acid
Molten adipic acid
Kyselina adipova
Adipinsaure [German]
Acide adipique [French]
FEMA No. 2011
Kyselina adipova [Czech]
Hexanedioate
Adipinsaeure
adipic-acid
Adipidic acid
Adi-pure
NSC 7622
Adipic acid [NF]
NSC-7622
Hexan-1,6-dicarboxylate
76A0JE0FKJ
Hexanedioc acid
INS NO.355
1,6-HEXANE-DIOIC ACID
E-355
CHEBI:30832
INS-355
NSC7622
Adipic acid (NF)
NCGC00091345-01
E355
hexane-1,6-dioic acid
Adipinsaure
Acide adipique
FEMA Number 2011
CAS-124-04-9
CCRIS 812
HSDB 188
EINECS 204-673-3
MFCD00004420
UNII-76A0JE0FKJ
BRN 1209788
Adipinate
Molten adipate
AI3-03700
hexane dioic acid
1,6-Hexanedioate
0L1
Adipic acid, 99%
Neopentyl Glycol Flake
Adipic acid-[13C6]
1, 6-Hexanedioic Acid
Adipic acid, >=99%
ADIPIC ACID [II]
ADIPIC ACID [MI]
WLN: QV4VQ
ADIPIC ACID [FCC]
bmse000424
EC 204-673-3
ADIPIC ACID [FHFI]
ADIPIC ACID [HSDB]
ADIPIC ACID [INCI]
SCHEMBL4930
CHEMBL1157
NCIOpen2_001004
NCIOpen2_001222
HOOC-(CH2)4-COOH
ADIPIC ACID [MART.]
Adipic acid, >=99.5%
4-02-00-01956 (Beilstein Handbook Reference)
ADIPIC ACID [USP-RS]
ADIPIC ACID [WHO-DD]
BIDD:ER0342
INS No. 355
DTXSID7021605
Adipic acid, puriss., 99.8%
Pharmakon1600-01301012
ADIPIC ACID [EP MONOGRAPH]
ZINC1530348
Tox21_111118
Tox21_202161
Tox21_300344
BBL011615
LMFA01170048
NSC760121
s3594
STL163338
AKOS000119031
Tox21_111118_1
CCG-230896
CS-W018238
HY-W017522
NSC-760121
NCGC00091345-02
NCGC00091345-03
NCGC00091345-04
NCGC00091345-05
NCGC00254389-01
NCGC00259710-01
AC-10343
BP-21150
BP-30248
Hexanedioic Acid, Butanedicarboxylic Acid
A0161
Adipic acid, BioXtra, >=99.5% (HPLC)
Adipic acid, SAJ special grade, >=99.5%
E 355
FT-0606810
EN300-18041
Adipic acid, Vetec(TM) reagent grade, >=99%
C06104
D08839
D70505
AB00988898-01
AB00988898-03
Q357415
SR-01000944270
J-005034
J-519542
SR-01000944270-2
Z57127533
Adipic acid, certified reference material, TraceCERT(R)
F0001-0377
Adipic acid, European Pharmacopoeia (EP) Reference Standard
1F1316F2-7A32-4339-8C2A-8CAA84696C95
Adipic acid, United States Pharmacopeia (USP) Reference Standard
124-04-9 [RN]
204-673-3 [EINECS]
Acide adipique [French] [ACD/IUPAC Name]
Adipic acid [ACD/IUPAC Name] [Wiki]
Adipinsäure [German] [ACD/IUPAC Name]
Asapic
Hexanedioic acid [ACD/Index Name]
Inipol DS
kwas adypinowy [Polish]
kyselina adipová [Czech]
MFCD00004420 [MDL number]
1,4-butanedicarboxylic acid
1,6-HEXANEDIOIC ACID
1,6-HEXANE-DIOIC ACID
121311-78-2 [RN]
19031-55-1 [RN]
2-Oxoadipic acid
52089-65-3 [RN]
Acifloctin
Acinetten
Adilactetten
Adipic Acid FCC
adipicacid
adipinic acid
Butane-1,4-dicarboxylic acid
BUTANEDICARBOXYLIC ACID
Hexanedioic-3,3,4,4-d4 Acid
hydron [Wiki]
QV4VQ [WLN]

SYNONYMS 1-Hexanoic acid; 1-Pentanecarboxylic acid; Butylacetic acid; Hexanoic acid; Hexoic acid; Hexylic acid; n-Caproic Acid; n-Hexanoic Acid; n-Hexoic acid; n-Hexylic acid; Pentiformic acid; Pentylformic acid; CAS NO. 142-62-1

HEXAPEPTIDE-10

DESCRIPTION:
Hexanoic acid, 2-ethyl-, also known as 2-ethylhexanoic acid or 2-EHA, is an industrial chemical.
A major use of Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is in the preparation of metal salts and soaps used as drying agents in paint and inks, and as thermal stabilizers in polyvinyl chloride (PVC).
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is also used in the manufacture of resins used in automobile windshields and vinyl flooring.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is not manufactured in Canada, but it is imported into Canada.

CAS:149-57-5
European Community (EC) Number: 205-743-6
Molecular Formula: C8H16O2


2-Ethylhexanoic acid, also known as 2-ethylhexanoate or alpha-ethylcaproic acid, belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. 2-Ethylhexanoic acid is a potentially toxic compound.


Ethylhexoic acid is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is slightly soluble in water.

Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is corrosive to metals and tissue.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is used to make paint dryers and plasticizers.

Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a branched-chain fatty acid.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a natural product found in Vitis vinifera and Artemisia arborescens with data available


Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is the organic compound with the formula CH3(CH2)3CH(C2H5)CO2H.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a carboxylic acid that is widely used to prepare lipophilic metal derivatives that are soluble in nonpolar organic solvents.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a colorless viscous oil.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is supplied as a racemic mixture.


PRODUCTION OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is produced industrially from propylene, which is hydroformylated to give butyraldehyde.
Aldol condensation of the aldehyde gives 2-ethylhexenal, which is hydrogenated to 2-ethylhexanal.
Oxidation of this aldehyde gives the carboxylic acid.


Metal ethylhexanoates:
65% Solution of cobalt(II) bis(2-ethylhexanoate) in mineral spirits, tilted vial to illustrate color and viscosity.
2-Ethylhexanoic acid forms compounds with metal cations that have stoichiometry as metal acetates.
These ethylhexanoate complexes are used in organic and industrial chemical synthesis.

They function as catalysts in polymerizations as well as for oxidation reactions as "oil drying agents."
They are highly soluble in nonpolar solvents.
These metal complexes are often described as salts. They are, however, not ionic but charge-neutral coordination complexes.
Their structures are akin to the corresponding acetates.



APPLICATIONS OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):

2-Ethylhexanoic Acid (2-EHA) is one of the flagship products within Perstorp Group which has the largest production capacity in the world.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a colorless liquid with one carboxylic group based on a C8 carbon chain.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is widely used in esters for PVB film plasticizers and synthetic lubricants, in production of metal soaps for paint driers, in automotive coolants and PVC stabilizers.

Other application areas include wood preservatives, catalyst for polyurethane and in pharmaceuticals.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is generally used to produce metal derivatives which are dissolved in nonpolar organic solvents.
2-Ethylhexanoic acid (EHXA, 2-EHA) is an industrially important aliphatic carboxylic acid.

Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is widely employed as a stabilizer and a wood preservative.

Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) has various industrial applications, such as:
• coolant in automotives
• synthetic lubricant
• wetting agent
• co-solvent
• drying of paints
• defoaming agent in pesticides


2-Ethylhexanoic acid (2-EHA) is a versatile monocarboxylic acid chemical intermediate.
Automotive:
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is used in the production of corrosion inhibitors for automotive coolants.

Coatings:
This monomer is used in the synthesis of alkyd resins provides improved yellowing resistanct than the standard fatty acids.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is particularly suitable for stoving enamels and two-component coatings.
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is also used as a raw material for metal based paint driers.

Lubricants :
Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is a major raw material for polyolesters used in synthetic lubricants.

Personal Care:
In cosmetics, Hexanoic acid, 2-ethyl-(2-ethylhexanoic acid) is used to produce emollients.

Other :
The production of polyvinylbutyral (PVB) plasticizers and polyvinylchloride (PVC) stabilizers in the form of metal salts.
Other applications include, catalyst for polymer production, raw material for acid chloride and fragrances.




SAFETY INFORMATION ABOUT HEXANOIC ACID, 2-ETHYL- (2-ETHYLHEXANOIC ACID):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






CHEMICAL AND PHYSICAL PROPERTIES OF HEXANOIC ACID, 2-ETHYL- (2-ETHYLHEXANOIC ACID):
Molecular Weight
144.21 g/mol
XLogP3
2.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
5
Exact Mass
144.115029749 g/mol
Monoisotopic Mass
144.115029749 g/mol
Topological Polar Surface Area
37.3Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
99.4
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Chemical formula, C8H16O2
Molar mass, 144.214 g•mol−1
Appearance, Colorless liquid
Density, 903 mg mL−1
Melting point, −59.00 °C; −74.20 °F; 214.15 K
Boiling point, 228.1 °C; 442.5 °F; 501.2 K
log P, 2.579
Vapor pressure, Acidity (pKa), 4.819
Basicity (pKb), 9.178
Refractive index (nD), 1.425
Thermochemistry,
Std enthalpy of formation (ΔfH⦵298), −635.1 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298), -4.8013–4.7979 MJ mol−1
CAS number, 149-57-5
EC index number, 607-230-00-6
EC number, 205-743-6
Hill Formula, C₈H₁₆O₂
Molar Mass, 144.21 g/mol
HS Code, 2915 90 70
Boiling point, 226 - 229 °C (1013 hPa)
Density, 0.91 g/cm3 (20 °C)
Explosion limit, 0.9 - 6.7 %(V)
Flash point, 114 °C
Ignition temperature, 310 °C
Melting Point, -59 °C
pH value, 3 (1.4 g/l, H₂O, 20 °C)
Vapor pressure, Solubility, 1.4 g/l


SYNONYMS OF HEXANOIC ACID, 2-ETHYL- (2-ETHYLHEXANOIC ACID):
2-ETHYLHEXANOIC ACID
149-57-5
2-Ethylcaproic acid
Hexanoic acid, 2-ethyl-
Ethylhexanoic acid
Ethylhexoic acid
2-Ethylhexoic acid
Butylethylacetic acid
2-Butylbutanoic acid
3-Heptanecarboxylic acid
Ethyl hexanoic acid
2-ethyl-hexoic acid
2-ethyl hexanoic acid
alpha-Ethylcaproic acid
2-ethyl-hexanoic acid
Ethyl hexanoic acid, 2-
alpha-ethyl caproic acid
.alpha.-Ethylcaproic acid
2-Ethyl-1-hexanoic acid
01MU2J7VVZ
2-ETHYL HEXOIC ACID,AR
61788-37-2
DTXSID9025293
CHEBI:89058
NSC-8881
2-ethylhexanoicacid
2-Ethylhexansaeure
DTXCID805293
2-Ethylhexanoic acid, >=99%
2-Ethylhexanoic acid, analytical standard
CAS-149-57-5
2 ETHYL HEXANOIC ACID
CCRIS 3348
HSDB 5649
Kyselina 2-ethylkapronova [Czech]
NSC 8881
Kyselina 2-ethylkapronova
EINECS 205-743-6
(+/-)-2-ETHYLHEXANOIC ACID
UNII-01MU2J7VVZ
Kyselina heptan-3-karboxylova [Czech]
BRN 1750468
Kyselina heptan-3-karboxylova
AI3-01371
Hexanoic acid, 2-ethyl-, (-)-
EINECS 262-971-9
MFCD00002675
2-Ethylcapronic acid
2-Ethyl-Hexonic acid
alpha-Ethylhexanoic acid
.alpha.-Ethylhexanoic acid
EC 205-743-6
SCHEMBL25800
2-Ethylhexanoic acid, 99%
MLS002415695
CHEMBL1162485
WLN: QVY4 & 2
NSC8881
HMS2267F21
STR05759
2-ETHYLHEXANOIC ACID [HSDB]
Tox21_201406
Tox21_300108
LMFA01020087
AKOS009031416
AT29893
CS-W016381
SB44987
SB44994
Hexanoic acid,2-ethyl-, tridecyl ester
NCGC00091324-01
NCGC00091324-02
NCGC00091324-03
NCGC00253985-01
NCGC00258957-01
SMR001252268
E0120
FT-0612273
FT-0654390
EN300-20410
Q209384
W-109079
F0001-0703
Z104478072
18FEB650-7573-4EA0-B0CD-9D8BED766547
2-Ethylhexanoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is the organic compound with the formula CH3(CH2)3CH(C2H5)CO2H.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a carboxylic acid that is widely used to prepare lipophilic metal derivatives that are soluble in nonpolar organic solvents.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.


CAS Number: 149-57-5
72377-05-0 S enantiomer
56006-48-5 R enantiomer
EC Number: 205-743-6
MDL number: MFCD00002675
Molecular Formula: C8H16O2 / CH3(CH2)3CH(C2H5)COOH
Chemical formula: C8H16O2



2-ETHYLHEXANOIC ACID, 149-57-5, 2-Ethylcaproic acid, Hexanoic acid, 2-ethyl-, Ethylhexanoic acid, Ethylhexoic acid, 2-Ethylhexoic acid, Butylethylacetic acid, 2-Butylbutanoic acid, 3-Heptanecarboxylic acid, Ethyl hexanoic acid, 2-ethyl-hexoic acid, 2-ethyl hexanoic acid, alpha-Ethylcaproic acid, 2-ethyl-hexanoic acid, Ethyl hexanoic acid, 2-, alpha-ethyl caproic acid, .alpha.-Ethylcaproic acid, 2-Ethyl-1-hexanoic acid, 61788-37-2, 01MU2J7VVZ, 2-EHA,
2-ETHYL HEXOIC ACID,AR, DTXSID9025293, CHEBI:89058, NSC-8881, MFCD00002675, 2-ethylhexanoicacid, 2-Ethylhexansaeure, DTXCID805293, 2-Ethylhexanoic acid, >=99%, 2-Ethylhexanoic acid, analytical standard, CAS-149-57-5, 2 ETHYL HEXANOIC ACID, CCRIS 3348, HSDB 5649, NSC 8881, Kyselina 2-ethylkapronova,
EINECS 205-743-6, (+/-)-2-ETHYLHEXANOIC ACID, UNII-01MU2J7VVZ, α-Ethylcaproic acid, α-Ethylhexanoic acid, Butylethylacetic acid, Ethylhexanoic acid, Ethylhexoic acid, 2-Butylbutanoic acid, 2-Ethylcaproic acid, 2-Ethylhexanoic acid, 2-Ethylhexoic acid, 3-Heptanecarboxylic acid, Kyselina 2-ethylkapronova, Kyselina heptan-3-karboxylova, 2-Ethyl-1-hexanoic acid, 2-Ethylcapronic acid, NSC 8881, 2-ethylhexyl 2-ethylhexanoate, ETHYLHEXYL ETHYLHEXANOATE, 2-Ethylhexyl-2-ethylhexanoat, 2-Ethylhexanoic acid, 2-ethylhexyl ester, Dragoxate EH, Hexanoic acid, 2-ethyl-, 2-ethylhexyl ester, DRAGOXAT EH, Hexanoic acid,2-ethyl-, Caproic acid,α-ethyl-, 2-Ethylhexanoic acid, Butylethylacetic acid, α-Ethylcaproic acid, 2-Ethylhexoic acid, 3-Heptanecarboxylic acid, 2-Ethylcaproic acid, Ethylhexanoic acid, α-Ethylhexanoic acid, 2-Butylbutanoic acid, 2-Ethyl-1-hexanoic acid, (±)-2-Ethylhexanoic acid, NSC 8881, Octylic acid, 83829-68-9, 202054-39-5 Hexanoic acid, 2-ethyl-, Ethylhexanoic acid, 2-ETHYLCAPROIC ACID, 2-ethylhexanoic, 2-Ethyl-1-hexanoic acid, Ethylhexoic acid, CAPRYLIC ACID(SG), 2-ETHYLCAPRONIC ACID, (RS)-2-Ethylhexansαure, 2-Ethylhexanoic acid, BRN 1750468, Kyselina heptan-3-karboxylova, AI3-01371, Hexanoic acid, 2-ethyl-, (-)-, EINECS 262-971-9, 2-Ethylcapronic acid, 2-Ethyl-Hexonic acid, alpha-Ethylhexanoic acid, .alpha.-Ethylhexanoic acid, EC 205-743-6, SCHEMBL25800, 2-Ethylhexanoic acid, 99%, MLS002415695, CHEMBL1162485, WLN: QVY4 & 2, NSC8881, HMS2267F21, STR05759, 2-ETHYLHEXANOIC ACID [HSDB],
Tox21_201406, Tox21_300108, LMFA01020087, AKOS009031416, AT29893, CS-W016381, SB44987, SB44994, Hexanoic acid,2-ethyl-, tridecyl ester, NCGC00091324-01, NCGC00091324-02, NCGC00091324-03, NCGC00253985-01, NCGC00258957-01, SMR001252268, E0120, FT-0612273, FT-0654390, NS00010660, EN300-20410, Q209384, W-109079,
F0001-0703, Z104478072, 18FEB650-7573-4EA0-B0CD-9D8BED766547, 2-Ethylhexanoic acid, Pharmaceutical Secondary Standard; Certified Reference Material,



Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless viscous oil.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is supplied as a racemic mixture.
Other applications of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) include, catalyst for polymer production, raw material for acid chloride and fragrances.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is slightly soluble in water.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is corrosive to metals and tissue.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) will burn though 2-Ethylhexanoic acid may take some effort to ignite.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is slightly soluble in water.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is corrosive to metals and tissue.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is the organic compound with the formula CH3(CH2)3CH(C2H5)CO2H.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a carboxylic acid that is widely used to prepare lipophilic metal derivatives that are soluble in nonpolar organic solvents.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless, high boiling liquid having a mild odor.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colourless liquid.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a branched-chain fatty acid.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid), also known as 2-ethylhexanoic acid or 2-EHA, is an industrial chemical.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) will burn though it may take some effort to ignite. It is slightly soluble in water.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is corrosive to metals and tissue.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a branched-chain fatty acid.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a natural product found in Vitis vinifera and Artemisia arborescens with data available.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is found in fruits.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is found in grapes.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) belongs to the family of Branched Fatty Acids.
These are fatty acids containing a branched chain.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is slightly soluble in water.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is corrosive to metals and tissue.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a branched-chain fatty acid.



USES and APPLICATIONS of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the production of corrosion inhibitors for automotive coolants.
Lubricants uses of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid): Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a major raw material for polyolesters used in synthetic lubricants.


Personal Care uses of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid): In cosmetics, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to produce emollients.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to make paint dryers and plasticizers.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the preparation of metal derivatives, which act as a catalyst in polymerization reactions.
For example, tin 2-ethylhexanoate is used in the manufacturing of poly(lactic-co-glycolic acid).
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is also used as a stabilizer for polyvinyl chlorides.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is also involved in solvent extraction and dye granulation.
Further, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to prepare plasticizers, lubricants, detergents, flotation aids, corrosion inhibitors and alkyd resins.


In addition to this, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) serves as a catalyst for polyurethane foaming.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used as a reactant in esterification , decarboxylative alkynylation , and preparation of alkyl coumarins via decarboxylative coupling reactions.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the organocatalytic medium for the preparation of various 3,4-dihydropyrimidin-2(1H)-ones/thiones by Biginelli reaction.
PHexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used paint and varnish driers (metallic salts).


Ethylhexoates of light metals are used to convert some mineral oils to greases.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid)'s esters are used as plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to make paint dryers and plasticizers.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the following products: anti-freeze products, laboratory chemicals and metal working fluids.


Other release to the environment of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is likely to occur from: indoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the following products: coating products.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to make paint dryers and plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the following areas: scientific research and development.


Release to the environment of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) can occur from industrial use: formulation of mixtures.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the following products: coating products, laboratory chemicals, lubricants and greases and metal working fluids.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.


Release to the environment of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) can occur from industrial use: manufacturing of the substance.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to make paint dryers and plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a colorless to light yellow liquid with a mild odor.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is slightly soluble in water.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is corrosive to metals and tissue.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used to make paint dryers and plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used Auto OEM


Cosmetic and personal care intermediate, Paints & coatings, and Pharmaceutical chemicals.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used the production of polyvinylbutyral (PVB) plasticizers and polyvinylchloride (PVC) stabilizers in the form of metal salts.


-Coatings uses of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is used in the synthesis of alkyd resins provides improved yellowing resistanct than the standard fatty acids.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is particularly suitable for stoving enamels and two-component coatings.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is also used as a raw material for metal based paint driers.



ALTERNATIVE PARENTS OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
*Branched fatty acids
*Monocarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
*Medium-chain fatty acid
*Branched fatty acid
*Monocarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



PREPARATION OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
In a dry 1L three-neck bottle, Add isooctyl aldehyde (80g, 0.62mol) And the solvent Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (240g, 1.66mol), ligand L8 (5.24mg, 0.007mmol), cesium carbonate (18.24mg, 0.056mmol), potassium acetate 160mg, placed in a water bath, mechanical under nitrogen atmosphere Stir, after the temperature rises to 30 ° C, Air flow was started at a flow rate of 11.9 g/h, and the reaction temperature was maintained at 30-35 ° C by adding cooling water to the water bath.
After 6 hours of reaction, the conversion of isooctyl aldehyde was calculated to be 99.6%.
The selectivity of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) was 99.5%, and the yield was 99.10%.



HOW IS HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) USED?
A major use of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is in the preparation of metal salts and soaps used as drying agents in paint and inks, and as thermal stabilizers in polyvinyl chloride (PVC).
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is also used in the manufacture of resins used in automobile windshields and vinyl flooring.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is not manufactured in Canada, but it is imported into Canada.



PRODUCTION OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is produced industrially from propylene, which is hydroformylated to give butyraldehyde.
Aldol condensation of the aldehyde gives 2-ethylhexenal, which is hydrogenated to 2-ethylhexanal.
Oxidation of this aldehyde gives the carboxylic acid.

Metal ethylhexanoates:
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) forms compounds with metal cations that have stoichiometry as metal acetates.
These ethylhexanoate complexes are used in organic and industrial chemical synthesis.

They function as catalysts in polymerizations as well as for oxidation reactions as "oil drying agents."
They are highly soluble in nonpolar solvents.
These metal complexes are often described as salts.

They are, however, not ionic but charge-neutral coordination complexes.
Their structures are akin to the corresponding acetates.

Examples of metal ethylhexanoates:
Hydroxyl aluminium bis(2-ethylhexanoate), used as a thickener
Tin(II) ethylhexanoate (CAS# 301-10-0), a catalyst for polylactide and poly(lactic-co-glycolic acid).
Cobalt(II) ethylhexanoate (CAS# 136-52-7), a drier for alkyd resins
Nickel(II) ethylhexanoate (CAS# 4454-16-4)



REACTIVITY PROFILE OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0.
Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.

Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.
Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.

Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.
Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.

A wide variety of products is possible.
Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.



PHYSICAL and CHEMICAL PROPERTIES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
Chemical formula: C8H16O2
Molar mass: 144.214 g·mol−1
Appearance: Colorless liquid
Density: 903 mg mL−1
Melting point: −59.00 °C; −74.20 °F; 214.15 K
Boiling point: 228.1 °C; 442.5 °F; 501.2 K
log P: 2.579
Vapor pressure: Acidity (pKa): 4.819
Basicity (pKb): 9.178
Refractive index (nD): 1.425
Std enthalpy of formation (ΔfH⦵298): −635.1 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): -4.8013–4.7979 MJ mol−1
Appearance: colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.89300 to 0.91300 @ 25.00 °C.
Pounds per Gallon - (est).: 7.431 to 7.597

Refractive Index: 1.42000 to 1.42600 @ 20.00 °C.
Melting Point: -59.00 °C. @ 760.00 mm Hg
Boiling Point: 220.00 to 223.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.030000 mmHg @ 20.00 °C.
Vapor Density: 4.98 ( Air = 1 )
Flash Point: 244.00 °F. TCC ( 117.78 °C. )
logP (o/w): 2.640
Soluble in: alcohol, water, 2000 mg/L @ 20 °C (exp)
Insoluble in: water
Molecular Weight: 144.21 g/mol
XLogP3: 2.6
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 5
Exact Mass: 144.115029749 g/mol
Monoisotopic Mass: 144.115029749 g/mol
Topological Polar Surface Area: 37.3Ų

Heavy Atom Count: 10
Formal Charge: 0
Complexity: 99.4
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Water Solubility: 2.07 g/L
logP: 2.61
logP: 2.8
logS: -1.8
pKa (Strongest Acidic): 5.14
Physiological Charge: -1
Hydrogen Acceptor Count: 2

Hydrogen Donor Count: 1
Polar Surface Area: 37.3 Ų
Rotatable Bond Count: 5
Refractivity: 40.25 m³·mol⁻¹
Polarizability: 16.99 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: No
Veber's Rule: Yes
MDDR-like Rule: No
Physical state: clear, liquid
Color: colorless
Odor: No data available
Melting point/freezing point:
Melting point/range: -59 °C

Initial boiling point and boiling range: 228 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 6,7 %(V)
Lower explosion limit: 0,9 %(V)
Flash point: 114 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 3 at 1,4 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: log Pow: 2,7 at 25 °C
Vapor pressure 13 hPa at 115 °C: < 0,01 hPa at 20 °C

Density: 0,903 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapo density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Relative vapor density: 4,98 - (Air = 1.0)
Chemical formula: C8H16O2
Molar mass: 144.214 g·mol−1
Appearance: Colorless liquid
Density: 903 mg mL−1
Melting point: −59.00 °C; −74.20 °F; 214.15 K
Boiling point: 228.1 °C; 442.5 °F; 501.2 K

log P: 2.579
Vapor pressure: Acidity (pKa): 4.819
Basicity (pKb): 9.178
Refractive index (nD) 1.425
Melting point: -59 °C
Boiling point: 228 °C(lit.)
Density: 0.906
vapor density: 4.98 (vs air)
vapor pressure: refractive index: n20/D 1.425(lit.)
Flash point: 230 °F
storage temp.: Store below +30°C.
solubility: 1.4g/l
form: Liquid

pka: pK1:4.895 (25°C)
color: Clear
PH: 3 (1.4g/l, H2O, 20℃)
Odor: Mild odour
PH Range: 3 at 1.4 g/l at 20 °C
Viscosity: 7.73 cps
explosive limit: 1.04%, 135°F
Water Solubility: 2 g/L (20 ºC)
BRN: 1750468
Exposure limits ACGIH: TWA 5 mg/m3
Stability: Stable.
Incompatible with strong oxidizing agents, reducing agents, bases.
InChIKey: OBETXYAYXDNJHR-UHFFFAOYSA-N
LogP: 2.7 at 25℃
CAS DataBase Reference: 149-57-5(CAS DataBase Reference)
EWG's Food Scores: 2

FDA UNII: 01MU2J7VVZ
NIST Chemistry Reference: Hexanoic acid, 2-ethyl-(149-57-5)
EPA Substance Registry System: 2-Ethylhexanoic acid (149-57-5)
Molecular Weight:293.40
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:293.22022309
Monoisotopic Mass:293.22022309
Topological Polar Surface Area:101
Heavy Atom Count:20
Complexity:155
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes




FIRST AID MEASURES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent and neutralising material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water
system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Viton
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 240 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep locked up or in an area accessible only to qualified or authorized persons.



STABILITY and REACTIVITY of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a branched-chain fatty acid.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a natural product found in Vitis vinifera and Artemisia arborescens with data available.


CAS Number: 149-57-5
72377-05-0 S enantiomer
56006-48-5 R enantiomer
EC Number: 205-743-6
MDL number: MFCD00002675
Molecular Formula: C8H16O2 / CH3(CH2)3CH(C2H5)COOH
Chemical formula: C8H16O2



SYNONYMS:
Hexanoic acid,2-ethyl-, Caproic acid,α-ethyl-, 2-Ethylhexanoic acid, Butylethylacetic acid, α-Ethylcaproic acid, 2-Ethylhexoic acid, 3-Heptanecarboxylic acid, 2-Ethylcaproic acid, Ethylhexanoic acid, α-Ethylhexanoic acid, 2-Butylbutanoic acid, 2-Ethyl-1-hexanoic acid, (±)-2-Ethylhexanoic acid, NSC 8881, Octylic acid, 83829-68-9, 202054-39-5, α-Ethylcaproic acid, α-Ethylhexanoic acid, Butylethylacetic acid, Ethylhexanoic acid, Ethylhexoic acid, 2-Butylbutanoic acid, 2-Ethylcaproic acid, 2-Ethylhexanoic acid, 2-Ethylhexoic acid, 3-Heptanecarboxylic acid, Kyselina 2-ethylkapronova, Kyselina heptan-3-karboxylova, 2-Ethyl-1-hexanoic acid, 2-Ethylcapronic acid, NSC 8881, 2-ETHYLHEXANOIC ACID, 149-57-5, 2-Ethylcaproic acid, Hexanoic acid, 2-ethyl-, Ethylhexanoic acid, Ethylhexoic acid, 2-Ethylhexoic acid, Butylethylacetic acid, 2-Butylbutanoic acid, 3-Heptanecarboxylic acid, Ethyl hexanoic acid, 2-ethyl-hexoic acid, 2-ethyl hexanoic acid, alpha-Ethylcaproic acid, 2-ethyl-hexanoic acid, Ethyl hexanoic acid, 2-, alpha-ethyl caproic acid, .alpha.-Ethylcaproic acid, 2-Ethyl-1-hexanoic acid, 61788-37-2, 01MU2J7VVZ, 2-EHA, 2-ETHYL HEXOIC ACID,AR, DTXSID9025293, CHEBI:89058, NSC-8881, MFCD00002675, 2-ethylhexanoicacid, 2-Ethylhexansaeure, DTXCID805293, 2-Ethylhexanoic acid, >=99%, 2-Ethylhexanoic acid, analytical standard, CAS-149-57-5, 2 ETHYL HEXANOIC ACID, CCRIS 3348, HSDB 5649, NSC 8881, Kyselina 2-ethylkapronova, EINECS 205-743-6, (+/-)-2-ETHYLHEXANOIC ACID, UNII-01MU2J7VVZ, α-Ethylcaproic acid, α-Ethylhexanoic acid, Butylethylacetic acid, Ethylhexanoic acid, Ethylhexoic acid, 2-Butylbutanoic acid, 2-Ethylcaproic acid, 2-Ethylhexanoic acid, 2-Ethylhexoic acid, 3-Heptanecarboxylic acid, Kyselina 2-ethylkapronova, Kyselina heptan-3-karboxylova, 2-Ethyl-1-hexanoic acid, 2-Ethylcapronic acid, NSC 8881, 2-ethylhexyl 2-ethylhexanoate, ETHYLHEXYL ETHYLHEXANOATE, 2-Ethylhexyl-2-ethylhexanoat, 2-Ethylhexanoic acid, 2-ethylhexyl ester, Dragoxate EH, Hexanoic acid, 2-ethyl-, 2-ethylhexyl ester, DRAGOXAT EH, Hexanoic acid,2-ethyl-, Caproic acid,α-ethyl-, 2-Ethylhexanoic acid, Butylethylacetic acid, α-Ethylcaproic acid, 2-Ethylhexoic acid, 3-Heptanecarboxylic acid, 2-Ethylcaproic acid, Ethylhexanoic acid, α-Ethylhexanoic acid, 2-Butylbutanoic acid, 2-Ethyl-1-hexanoic acid, (±)-2-Ethylhexanoic acid, NSC 8881, Octylic acid, 83829-68-9, 202054-39-5 Hexanoic acid, 2-ethyl-, Ethylhexanoic acid, 2-ETHYLCAPROIC ACID, 2-ethylhexanoic, 2-Ethyl-1-hexanoic acid, Ethylhexoic acid, CAPRYLIC ACID(SG), 2-ETHYLCAPRONIC ACID, (RS)-2-Ethylhexansαure, 2-Ethylhexanoic acid, BRN 1750468, Kyselina heptan-3-karboxylova, AI3-01371, Hexanoic acid, 2-ethyl-, (-)-, EINECS 262-971-9, 2-Ethylcapronic acid, 2-Ethyl-Hexonic acid, alpha-Ethylhexanoic acid, .alpha.-Ethylhexanoic acid, EC 205-743-6, SCHEMBL25800, 2-Ethylhexanoic acid, 99%, MLS002415695, CHEMBL1162485, WLN: QVY4 & 2, NSC8881, HMS2267F21, STR05759, 2-ETHYLHEXANOIC ACID [HSDB], Tox21_201406, Tox21_300108, LMFA01020087, AKOS009031416, AT29893, CS-W016381, SB44987, SB44994, Hexanoic acid,2-ethyl-, tridecyl ester, NCGC00091324-01, NCGC00091324-02, NCGC00091324-03, NCGC00253985-01, NCGC00258957-01, SMR001252268, E0120, FT-0612273, FT-0654390, NS00010660, EN300-20410, Q209384, W-109079, F0001-0703, Z104478072, 18FEB650-7573-4EA0-B0CD-9D8BED766547, 2-Ethylhexanoic acid, Pharmaceutical Secondary Standard; Certified Reference Material,



Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is slightly soluble in water.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is corrosive to metals and tissue.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a branched-chain fatty acid.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a natural product found in Vitis vinifera and Artemisia arborescens with data available.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is found in fruits.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is found in grapes.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) belongs to the family of Branched Fatty Acids.


These are fatty acids containing a branched chain.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is slightly soluble in water.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is corrosive to metals and tissue.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is an industrial chemical.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a versatile monocarboxylic acid chemical intermediate.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is the organic compound with the formula CH3(CH2)3CH(C2H5)CO2H.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a carboxylic acid that is widely used to prepare lipophilic metal derivatives that are soluble in nonpolar organic solvents.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless viscous oil.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is supplied as a racemic mixture.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) will burn though it may take some effort to ignite. It is slightly soluble in water.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is corrosive to metals and tissue.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to make paint dryers and plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is slightly soluble in water.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is corrosive to metals and tissue.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to make paint dryers and plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a branched-chain fatty acid.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colorless to light yellow liquid with a mild odor.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) will burn though it may take some effort to ignite.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is slightly soluble in water.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is corrosive to metals and tissue.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to make paint dryers and plasticizers.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a colourless liquid



USES and APPLICATIONS of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the following products: anti-freeze products, laboratory chemicals and metal working fluids.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the following areas: scientific research and development.
Other release to the environment of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is likely to occur from: indoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the following products: coating products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the following products: coating products, laboratory chemicals, lubricants and greases and metal working fluids.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) can occur from industrial use: manufacturing of the substance.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to make paint dryers and plasticizers.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to make paint dryers and plasticizers.
Automotive: Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the production of corrosion inhibitors for automotive coolants.
A major use of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is in the preparation of metal salts and soaps used as drying agents in paint and inks, and as thermal stabilizers in polyvinyl chloride (PVC).


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is also used in the manufacture of resins used in automobile windshields and vinyl flooring.
Lubricants uses of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA): Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a major raw material for polyolesters used in synthetic lubricants.


Personal Care: In cosmetics, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to produce emollients.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used the production of polyvinylbutyral (PVB) plasticizers and polyvinylchloride (PVC) stabilizers in the form of metal salts.


Other applications of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) include, catalyst for polymer production, raw material for acid chloride and fragrances.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the preparation of metal derivatives, which act as a catalyst in polymerization reactions.


For example, tin 2-ethylhexanoate is used in the manufacturing of poly(lactic-co-glycolic acid).
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is also used as a stabilizer for polyvinyl chlorides.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is also involved in solvent extraction and dye granulation.


Further, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used to prepare plasticizers, lubricants, detergents, flotation aids, corrosion inhibitors and alkyd resins.
In addition to this, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) serves as a catalyst for polyurethane foaming.


2-Ethylhexanoic acid can be used as a reactant in esterification , decarboxylative alkynylation , and preparation of alkyl coumarins via decarboxylative coupling reactions.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used in the organocatalytic medium for the preparation of various 3,4-dihydropyrimidin-2(1H)-ones/thiones by Biginelli reaction.


Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is used paint and varnish driers (metallic salts).
Ethylhexoates of light metals are used to convert some mineral oils to greases.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA)'s esters are used as plasticizers.


-Coatings uses of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA):
This monomer, Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA), is used in the synthesis of alkyd resins provides improved yellowing resistanct than the standard fatty acids.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is particularly suitable for stoving enamels and two-component coatings.
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is also used as a raw material for metal based paint driers.



PRODUCTION OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is produced industrially from propylene, which is hydroformylated to give butyraldehyde.
Aldol condensation of the aldehyde gives 2-ethylhexenal, which is hydrogenated to 2-ethylhexanal.
Oxidation of this aldehyde gives the carboxylic acid.

*Metal ethylhexanoates
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) forms compounds with metal cations that have stoichiometry as metal acetates.
These ethylhexanoate complexes are used in organic and industrial chemical synthesis.

They function as catalysts in polymerizations as well as for oxidation reactions as "oil drying agents."
They are highly soluble in nonpolar solvents.
These metal complexes are often described as salts.

They are, however, not ionic but charge-neutral coordination complexes.
Their structures are akin to the corresponding acetates.

Examples of metal ethylhexanoates:
Hydroxyl aluminium bis(2-ethylhexanoate), used as a thickener
Tin(II) ethylhexanoate (CAS# 301-10-0), a catalyst for polylactide and poly(lactic-co-glycolic acid).
Cobalt(II) ethylhexanoate (CAS# 136-52-7), a drier for alkyd resins
Nickel(II) ethylhexanoate (CAS# 4454-16-4)



PREPARATION OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
In a dry 1L three-neck bottle, Add isooctyl aldehyde (80g, 0.62mol) And the solvent Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) (240g, 1.66mol), ligand L8 (5.24mg, 0.007mmol), cesium carbonate (18.24mg, 0.056mmol), potassium acetate 160mg, placed in a water bath, mechanical under nitrogen atmosphere

Stir, after the temperature rises to 30 ° C, Air flow was started at a flow rate of 11.9 g/h, and the reaction temperature was maintained at 30-35 ° C by adding cooling water to the water bath.
After 6 hours of reaction, the conversion of isooctyl aldehyde was calculated to be 99.6%.
The selectivity of Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) was 99.5%, and the yield was 99.10%.



ALTERNATIVE PARENTS OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
*Branched fatty acids
*Monocarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
*Medium-chain fatty acid
*Branched fatty acid
*Monocarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



REACTIVITY PROFILE OF HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
Hexanoic acid, 2-ethyl-(2-Ethylhexanoic acid) (2-EHA) is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.

The reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides generates flammable and/or toxic gases and heat.
Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.

Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.
Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.

These reactions generate heat.
A wide variety of products is possible.
Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.



PHYSICAL and CHEMICAL PROPERTIES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
Chemical form
Molecular Weight: 144.21100 g/mol
Exact Mass: 144.21
EC Number: 262-971-9
ICSC Number: 0477
NSC Number: 8881
UN Number: 1993
DSSTox ID: DTXSID9025293
Color/Form: Clear liquid
HScode: 29159080
Density: 0.9031 g/cm3 @ 25 °C
Melting Point: -59 °C
Boiling Point: 228 °C
Flash Point: 114ºC
Refractive Index: 1.424-1.426

Water Solubility: Solubility in water, g/100ml: 0.14 (very poor)
Storage Conditions: Keep container closed when not in use.
Store in a cool, dry, well-ventilated area away from incompatible substances.
Vapor Pressure: Vapor Density: 4.98 (vs air)
Flammability Characteristics: Lower flammable limit: 0.8% by volume;
Upper flammable limit: 6.0% by volume
Explosive Limit: vol% in air: 0.8
Odor: Mild odor
Henry's Law Constant: Henry's Law constant = 2.8X10-6 atm-cu m/mol at 25 °C (est)
Experimental Properties: Hydroxyl radical reaction rate constant = 8.18X10-12 cu cm/molec-sec at 25 °C (est)
Air and Water Reactions: No rapid reaction with air.
No rapid reaction with water.
Reactive Group: Acids, Carboxylic

Appearance: Colorless liquid
Density: 903 mg mL−1
Melting point: −59.00 °C; −74.20 °F; 214.15 K
Boiling point: 228.1 °C; 442.5 °F; 501.2 K
log P: 2.579
Vapor pressure: Acidity (pKa): 4.819
Basicity (pKb): 9.178
Refractive index (nD): 1.425
Std enthalpy of formation (ΔfH⦵298): −635.1 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): -4.8013–4.7979 MJ mol−1
Appearance: colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.89300 to 0.91300 @ 25.00 °C.

Pounds per Gallon - (est).: 7.431 to 7.597
Refractive Index: 1.42000 to 1.42600 @ 20.00 °C.
Melting Point: -59.00 °C. @ 760.00 mm Hg
Boiling Point: 220.00 to 223.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.030000 mmHg @ 20.00 °C.
Vapor Density: 4.98 ( Air = 1 )
Flash Point: 244.00 °F. TCC ( 117.78 °C. )
logP (o/w): 2.640
Soluble in: alcohol, water, 2000 mg/L @ 20 °C (exp)
Insoluble in: water
Molecular Weight: 144.21 g/mol
XLogP3: 2.6
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2

Rotatable Bond Count: 5
Exact Mass: 144.115029749 g/mol
Monoisotopic Mass: 144.115029749 g/mol
Topological Polar Surface Area: 37.3Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 99.4
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Water Solubility: 2.07 g/L

logP: 2.61
logP: 2.8
logS: -1.8
pKa (Strongest Acidic): 5.14
Physiological Charge: -1
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 37.3 Ų
Rotatable Bond Count: 5
Refractivity: 40.25 m³·mol⁻¹
Polarizability: 16.99 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: No
Autoignition Temperature: 699 °F (USCG, 1999) | 700 °F (371 °C) | 371 °C

Critical Temperature & Pressure:
Critical temperature: 615.2 Kula: C8H16O2
Molar mass: 144.214 g·mol−1
Veber's Rule: Yes
MDDR-like Rule: No
Physical state: clear, liquid
Color: colorless
Odor: No data available
Melting point/freezing point:
Melting point/range: -59 °C
Initial boiling point and boiling range: 228 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 6,7 %(V)
Lower explosion limit: 0,9 %(V)
Flash point: 114 °C - closed cup

Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 3 at 1,4 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: log Pow: 2,7 at 25 °C
Vapor pressure 13 hPa at 115 °C: < 0,01 hPa at 20 °C
Density: 0,903 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapo density: No data available
Particle characteristics: No data available
Explosive properties: No data available

Oxidizing properties: No data available
Other safety information:
Relative vapor density: 4,98 - (Air = 1.0)
Chemical formula: C8H16O2
Molar mass: 144.214 g·mol−1
Appearance: Colorless liquid
Density: 903 mg mL−1
Melting point: −59.00 °C; −74.20 °F; 214.15 K
Boiling point: 228.1 °C; 442.5 °F; 501.2 K
log P: 2.579
Vapor pressure: Acidity (pKa): 4.819
Basicity (pKb): 9.178
Refractive index (nD) 1.425

Melting point: -59 °C
Boiling point: 228 °C(lit.)
Density: 0.906
vapor density: 4.98 (vs air)
vapor pressure: refractive index: n20/D 1.425(lit.)
Flash point: 230 °F
storage temp.: Store below +30°C.
solubility: 1.4g/l
form: Liquid
pka: pK1:4.895 (25°C)
color: Clear
PH: 3 (1.4g/l, H2O, 20℃)

Odor: Mild odour
PH Range: 3 at 1.4 g/l at 20 °C
Viscosity: 7.73 cps
explosive limit: 1.04%, 135°F
Water Solubility: 2 g/L (20 ºC)
BRN: 1750468
Exposure limits ACGIH: TWA 5 mg/m3
Stability: Stable.
Incompatible with strong oxidizing agents, reducing agents, bases.
InChIKey: OBETXYAYXDNJHR-UHFFFAOYSA-N
LogP: 2.7 at 25℃
CAS DataBase Reference: 149-57-5(CAS DataBase Reference)
EWG's Food Scores: 2

FDA UNII: 01MU2J7VVZ
NIST Chemistry Reference: Hexanoic acid, 2-ethyl-(149-57-5)
EPA Substance Registry System: 2-Ethylhexanoic acid (149-57-5)
Molecular Weight:293.40
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:293.22022309
Monoisotopic Mass:293.22022309
Topological Polar Surface Area:101
Heavy Atom Count:20
Complexity:155
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes



FIRST AID MEASURES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent and neutralising material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water
system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Viton
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 240 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep locked up or in an area accessible only to qualified or authorized persons.



STABILITY and REACTIVITY of HEXANOIC ACID, 2-ETHYL-(2-ETHYLHEXANOIC ACID) (2-EHA):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

Hexanol is a linear primary alcohol.
Hexanol (IUPAC name hexan-1-ol) is an organic alcohol with a six-carbon chain and a condensed structural formula of CH3(CH2)5OH.
Hexanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.

CAS Number: 111-27-3
EC Number: 203-852-3
Molecular Formula: C6H14O
Molecular Weight (g/mol): 102.177

Two additional straight chain isomers of Hexanol, 2-hexanol and 3-hexanol, exist, both of which differing by the location of the hydroxyl group.
Many isomeric alcohols have the formula C6H13OH.
Hexanol is used in the perfume industry.

Hexanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.
Further, Hexanol serves as a perturbing agent on actomyosin adenosine triphosphatease.
In addition to this, Hexanol is used to modulate the function of actomyosin motor.

Hexanol is an organic alcohol with a six carbon chain and a condensed structural formula of CH3(CH2)5OH.
This colorless liquid is slightly soluble in water, but miscible with ether and ethanol.

Two additional straight chain isomers of Hexanol exist, 2-hexanol and 3-hexanol, both of which differ by the location of the hydroxyl group.
Many isomeric alcohols have the formula C6H13OH.

Hexanol (IUPAC name hexan-1-ol) is an organic alcohol with a six-carbon chain and a condensed structural formula of CH3(CH2)5OH.
This colorless liquid is slightly soluble in water, but miscible with diethyl ether and ethanol.

Hexanol is believed to be a component of the odour of freshly mown grass.
Hexanol is used in the perfume industry.

Hexanol is an organic alcohol with a six carbon chain and a condensed structural formula of CH3(CH2)5OH.
This colorless liquid is slightly soluble in water, but miscible with ether and ethanol.

Hexanol is a linear primary alcohol.
Hexanol is formed as an intermediate during the catalytic transformation of cellulose.

The ability of 1,1,3,3-tetramethylguanidine (TMG) in Hexanol solvent system to capture carbon dioxide has been assessed.
The solubility of light fullerenes in Hexanol as a function of temperature and pressure was studied.

Hexanol is produced from coconut oil and palm oils.
Hexanol is used in the production of antiseptics, fragrances and perfumes.
Hexanol is also used as a solvent in the production of plasticizers.

Two additional straight chain isomers of Hexanol exist, 2-hexanol and 3-hexanol, both of which differ by the location of the hydroxyl group.
Many isomeric alcohols have the formula C6H13OH.
Hexanol is an alcohol extracted from yeast and produced during fermentation of alcoholic beverages.

Applications of Hexanol:
Hexanol is used to make plasticizers for polyvinyl chloride.
Reaction with phthalic anhydride gives bis(2-ethyl hexyl) phthalate (DOP, DEHP).

Reaction with adipic acid gives bis(2-ethyl hexyl) adipate.
Moreover, esterification with acrylic acid gives 2-ethyl hexyl acrylate for use in adhesives and paints.
On the other hand, because Hexanol can dissolve many organic materials well, Hexanol is widely used as a low-volatility solvent.

Hexanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.
Further, Hexanol serves as a perturbing agent on actomyosin adenosine triphosphatease.
In addition to this, Hexanol is used to modulate the function of actomyosin motor.

Uses of Hexanol:
Hexanol is used to produce plasticizers, antiseptics, fragrances, pharmaceuticals, and finishing agents for textile and leather.
Hexanol is used as a flavoring agent and a solvent for fats, waxes, dyes, and paints.

Hexanol is synthetic flavoring ingredient
Hexanol is used in pharmaceuticals (introduction of hexyl group into hyponics, antiseptics, perfume esters, etc), solvent, plasticizer, intermediate for textile and leather finishing agents.

Industry Uses:
Aerating and deaerating agents
Fuel
Intermediate
Lubricating agent
Monomers
Solvent
Solvents (which become part of product formulation or mixture)
Surfactant (surface active agent)
Wetting agent (non-aqueous)

Consumer Uses:
Flavoring and nutrient
Fuel
Lubricating agent
Monomers
Solvent

Industrial Processes with risk of exposure:
Painting (Solvents)

Preparation of Hexanol:
Hexanol is produced industrially by the oligomerization of ethylene using triethylaluminium followed by oxidation of the alkylaluminium products.

An idealized synthesis is shown:
Al(C2H5)3 + 6C2H4 → Al(C6H13)3
Al(C6H13)3 + 1+1⁄2O2 + 3H2O → 3HOC6H13 + Al(OH)3

The process generates a range of oligomers that are separated by distillation.

Alternative methods:
Another method of preparation entails hydroformylation of 1-pentene followed by hydrogenation of the resulting aldehydes.
This method is practiced in industry to produce mixtures of isomeric C6-alcohols, which are precursors to plasticizers.

In principle, 1-hexene could be converted to Hexanol by hydroboration (diborane in tetrahydrofuran followed by treatment with hydrogen peroxide and sodium hydroxide).
This method is instructive and useful in laboratory synthesis but of no practical relevance because of the commercial availability of inexpensive Hexanol from ethylene.

Manufacturing Methods of Hexanol:
Addition of ethylene to triethylaluminum followed by oxidation of the growth product, hydrolysis, and fractional distillation; from condensation of n-butyraldehyde and acetaldehyde, followed by dehydration and hydrogenation.

Laboratory preparation by action of butylmagnesium bromide on ethylene oxide 1,3-hexadienal with iron wire in presence of nickel acetate
Industrial preparation by reducing ethyl caproate with sodium in absolute alcohol.

Reaction of acetaldehyde and crotonaldehyde followed by hydrogenation.

General Manufacturing Information of Hexanol:

Industry Processing Sectors:
Agriculture, Forestry, Fishing and Hunting
All Other Basic Organic Chemical Manufacturing
Mining (except Oil and Gas) and support activities
Oil and Gas Drilling, Extraction, and Support activities
Other (requires additional information)
Paint and Coating Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Petrochemical Manufacturing
Petroleum Lubricating Oil and Grease Manufacturing
Plastics Material and Resin Manufacturing
Plastics Product Manufacturing

Commercial products from the family of 6 to 11 carbon alcohols that make up the plasticizer range are available both as pure single carbon chain materials and as complex isomeric mixtures.
Commercial descriptions of plasticizer range alcohols are in general a pure material is called "-anol" /eg, Hexanol/, and the mixtures are called "-yl alcohol /eg, hexyl alcohol/ or "iso...yl alcohol" /isohexyl alcohol/.

Occurrence in Nature of Hexanol:
Hexanol is believed to be a component of the odour of freshly mown grass.
Alarm pheromones emitted by the Koschevnikov gland of honey bees contain Hexanol.
Hexanol also is partly responsible for the fragrance of strawberries.

Characteristics of Hexanol:
Hexanol, also called octanol, is an 8-carbon higher alcohol species.
Hexanol is hardly soluble in water, but is soluble in almost all organic solvents.
Our Hexanol has very low-level impurities and may be used as a raw material for a wide variety of chemicals.

MeSH Pharmacological Classification of Hexanol:

Nicotinic Antagonists:
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists.
Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.

Anesthetics:
Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain.
They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.

Action Mechanism of Hexanol:
Ethanol and Hexanol were found to have two competing concentration-dependent effects on the Ca(2+)- and phorbol ester- or diacylglycerol-dependent activities of PKCalpha associated with either RhoA or Cdc42, consisting of a potentiation at low alcohol levels and an attenuation of activity at higher levels.
Measurements of the Ca(2+), phorbol ester, and diacylglycerol concentration-response curves for Cdc42-induced activation indicated that the activating effect corresponded to a shift in the midpoints of each of the curves to lower activator concentrations, while the attenuating effect corresponded to a decrease in the level of activity induced by maximal activator levels.
The presence of ethanol enhanced the interaction of PKCalpha with Cdc42 within a concentration range corresponding to the potentiating effect, whereas the level of binding was unaffected by higher ethanol levels that were found to attenuate activity.

Human Metabolite Information of Hexanol:

Cellular Locations:
Extracellular
Membrane

Reactivity Profile of Hexanol:
Hexanol is an alcohol.
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents.

They react with oxoacids and carboxylic acids to form esters plus water.
Oxidizing agents convert them to aldehydes or ketones.

Alcohols exhibit both weak acid and weak base behavior.
They may initiate the polymerization of isocyanates and epoxides.

Handling and Storage of Hexanol:

Nonfire Spill Response:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
All equipment used when handling the product must be grounded.

Do not touch or walk through spilled material.
Stop leak if you can do Hexanol without risk.

Prevent entry into waterways, sewers, basements or confined areas.
A vapor-suppressing foam may be used to reduce vapors.

Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL:
Dike far ahead of liquid spill for later disposal.
Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Safe Storage:
Separated from strong oxidants.

Storage Conditions:
Protect containers against physical damage.
Keep containers closed and store in well-ventilated, cool place.

Fire Fighting of Hexanol:
The majority of these products have a very low flash point.
Use of water spray when fighting fire may be inefficient.

SMALL FIRE:
Dry chemical, CO2, water spray or alcohol-resistant foam.
Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE:
Water spray, fog or alcohol-resistant foam.
Avoid aiming straight or solid streams directly onto the product.
If Hexanol can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS:
Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.

Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

For massive fire, use unmanned master stream devices or monitor nozzles.
If this is impossible, withdraw from area and let fire burn.

Use alcohol-resistant foam, dry powder, carbon dioxide.
In case of fire: keep drums, etc., cool by spraying with water.

Fire Fighting Procedures of Hexanol:
Use carbon dioxide, dry chemical or "alcohol" foam extinguisher.
Water is ineffective to fire fighting, but is effective to keep fire-exposed containers cool.

If material on fire or involved in fire:
Do not extinguish fire unless flow can be stopped.
Use water in flooding quantities as fog.

Solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water.

Apply water from as far a distance as possible.
Use "alcohol" foam, carbon dioxide or dry chemical.
Keep run off water out of sewers and water sources.

Accidental Release Measures of Hexanol:

IMMEDIATE PRECAUTIONARY MEASURE:
Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL:
Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE:
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions.
Also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Spillage Disposal of Hexanol:

Personal protection:
Filter respirator for organic gases and vapours adapted to the airborne concentration of Hexanol.
Collect leaking and spilled liquid in covered containers as far as possible.

Absorb remaining liquid in sand or inert absorbent.
Then store and dispose of according to local regulations.

Cleanup Methods of Hexanol:
Absorb on paper.
Evaporate on a glass or iron dish in hood.
Burn the paper.

Disposal Methods of Hexanol:
The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination.
Recycle any unused portion of the material for Hexanol approved use or return it to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
The material's impact on air quality.
Potential migration in soil or water

Effects on animal, aquatic, and plant life.
Conformance with environmental and public health regulations.

Spray into the furnace.
Incineration will become easier by mixing with a more flammable solvent.

Preventive Measures of Hexanol:

If material not on fire and not involved in fire:
Keep sparks, flames, and other sources of ignition away.
Keep material out of water sources and sewers.

Build dikes to contain flow as necessary.
Attempt to stop leak if without undue personnel hazard.
Use water spray to knock-down vapors.

Personnel protection:
Avoid breathing vapors.
Avoid bodily contact with the material.

Do not handle broken packages unless wearing appropriate personal protective equipment.
Wash away any material which may have contacted the body with copious amounts of water or soap and water.
If contact with the material anticipated, wear appropriate chemical protective clothing.

Identifiers of Hexanol:
CAS Number: 111-27-3
Beilstein Reference 969167
ChEBI: CHEBI:87393
ChEMBL: ChEMBL14085
ChemSpider: 7812
ECHA InfoCard: 100.003.503
EC Number: 203-852-3
MeSH: 1-Hexanol
PubChem CID: 8103
RTECS number: MQ4025000
UNII: 6CP2QER8GS
UN number: 2282
CompTox Dashboard (EPA): DTXSID8021931
InChI: InChI=1S/C6H14O/c1-2-3-4-5-6-7/h7H,2-6H2,1H3
Key: ZSIAUFGUXNUGDI-UHFFFAOYSA-N
SMILES: CCCCCCO

CAS number: 111-27-3
EC index number: 603-059-00-6
EC number: 203-852-3
Hill Formula: C₆H₁₄O
Molar Mass: 102.18 g/mol
HS Code: 2905 19 00

Synonym(s): Hexyl alcohol
Linear Formula: CH3(CH2)5OH
CAS Number: 111-27-3
Molecular Weight: 102.17
Beilstein: 969167
EC Number: 203-852-3
MDL number: MFCD00002982
PubChem Substance ID: 57650899
NACRES: NA.21

CAS: 111-27-3
Molecular Formula: C6H14O
Molecular Weight (g/mol): 102.177
MDL Number: MFCD00002982
InChI Key: ZSIAUFGUXNUGDI-UHFFFAOYSA-N
PubChem CID: 8103
ChEBI: CHEBI:87393
IUPAC Name: hexan-1-ol
SMILES: CCCCCCO

Properties of Hexanol:
Chemical formula: C6H14O
Molar mass: 102.177 g·mol−1
Appearance colorless: liquid
Density: 0.82 g cm−3 (at 20 °C)[2]
Melting point: −45 °C (−49 °F; 228 K)
Boiling point: 157 °C (315 °F; 430 K)
Solubility in water: 5.9 g/L (at 20 °C)
log P: 1.858
Vapor pressure: 100 Pa (at 25.6 °C)
Refractive index (nD): 1.4178 (at 20 °C)

Density: 0.82 g/cm3 (20 °C)
Explosion limit: 1.2 - 7.7 %(V)
Flash point: 60 °C
Ignition temperature: 285 °C
Vapor pressure: 3.64 hPa (38 °C)
Viscosity kinematic: 3.64 mm2/s (40 °C)
Solubility: 1.3 g/l

Grade: anhydrous
Quality Level: 100
Vapor density: 4.5 (vs air)
Vapor pressure: 1 mmHg ( 25.6 °C)
Assay: ≥99%
Form: liquid
Autoignition temp.: 559 °F
Expl. lim.: 0.34-6.3 %
Impurities: <0.005% water
evapn. residue: <0.0005%
Refractive index: n20/D 1.418 (lit.)
bp: 156-157 °C (lit.)
mp: −52 °C (lit.)
Density: 0.814 g/mL at 25 °C (lit.)
SMILES string: CCCCCCO
InChI: 1S/C6H14O/c1-2-3-4-5-6-7/h7H,2-6H2,1H3
InChI key: ZSIAUFGUXNUGDI-UHFFFAOYSA-N

Molecular Weight: 102.17
XLogP3: 2
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 4
Exact Mass: 102.104465066
Monoisotopic Mass: 102.104465066
Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 7
Complexity: 27.4
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Hexanol:
Assay (GC, area%): ≥ 98 %
Density (d 20 °C/ 4 °C): 0.818 - 0.819
Identity (IR): passes test

Melting Point: -52°C
Density: 0.814
Boiling Point: 157°C
Flash Point: 60°C (140°F)
Assay Percent Range: 99%
Linear Formula: CH3(CH2)5OH
UN Number: UN2282
Beilstein: 969167
Merck Index: 14,4697
Refractive: Index 1.418
Quantity: 2500 mL
Solubility Information: Miscible with ethanol, acetone, chloroform, ether, benzene. Slightly miscible with carbon tetrachloride and water.
Formula Weight: 102.18
Percent Purity: 99%
Chemical Name or Material: 1-Hexanol

Thermochemistry of Hexanol:
Heat capacity (C): 243.2 J K−1 mol−1
Std molar entropy (S⦵298): 287.4 J K−1 mol−1
Std enthalpy of formation (ΔfH⦵298): −377.5 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): −3.98437 MJ mol−1

Names of Hexanol:

Preferred IUPAC name:
Hexan-1-ol

Other names:
amyl carbinol

Synonyms of Hexanol:
1-Hexanol
Hexan-1-ol
Hexyl alcohol
111-27-3
HEXANOL
n-Hexanol
n-Hexyl alcohol
Amylcarbinol
1-Hydroxyhexane
1-Hexyl alcohol
Caproyl alcohol
Pentylcarbinol
Caproic alcohol
n-Hexan-1-ol
C6 alcohol
Alcohol(C6)
Hexanol (VAN)
EPAL 6
Hexyl alcohol (natural)
Alcohol C-6
FEMA No. 2567
NSC 9254
MFCD00002982
Hexanol-(1)
6CP2QER8GS
25917-35-5
CHEBI:87393
NSC-9254
Caswell No. 482E
Hydroxyhexane
Hexanols
FEMA Number 2567
CAS-111-27-3
HE2
HSDB 565
EINECS 203-852-3
UNII-6CP2QER8GS
EPA Pesticide Chemical Code 079047
BRN 0969167
Caproalcohol
Hexalcohol
HEXYL ALCOHOL, ACTIVE
n-hexylalcohol
AI3-08157
N-hexenol
Nat.Hexanol
Exxal 6
EINECS 247-346-0
HEXANOL-CMPD
Exxal 6 (Salt/Mix)
BDBM9
1-Hexanol, 98%
Hexyl alcohol, FCC, FG
1-HEXANOL [HSDB]
1-HEXANOL [MI]
EC 203-852-3
n-C6H13OH
SCHEMBL1877
HEXYL ALCOHOL [FCC]
NATURAL HEXYL ALCOHOL
C6H13OH
HEXYL ALCOHOL [FHFI]
HEXYL ALCOHOL [INCI]
WLN: Q6
4-01-00-01694 (Beilstein Handbook Reference)
MLS001055374
UN 2282 (Salt/Mix)
BIDD:ER0298
CHEMBL14085
1-Hexanol, analytical standard
DTXSID8021931
1-Hexanol, anhydrous, >=99%
NSC9254
1-Hexanol, reagent grade, 98%
DTXSID001022586
HMS3039L08
BCP29486
ZINC1699882
Tox21_201335
Tox21_302953
LMFA05000117
STL282713
UN2282
AKOS009031422
HY-W032022
Alcohol C-6, Natural, Natural Hexanol
1-Hexanol, purum, >=98.0% (GC)
1-Hexyl alcohol pound>>1-Hexylalcohol
NCGC00090949-01
NCGC00090949-02
NCGC00256385-01
NCGC00258887-01
Hexanols [UN2282] [Flammable liquid]
LS-13216
SMR000677945
1-Hexanol, SAJ special grade, >=99.0%
1-Hexanol, Vetec(TM) reagent grade, 98%
CS-0076046
FT-0607887
H0130
Hexyl alcohol, natural, >=98%, FCC, FG
EN300-19338
Q76933
1-Hexanol, ReagentPlus(R), >=99.5% (GC)
J-002549
F0001-0237
Z104473568
111-27-3 [RN]
1-Hexanol [ACD/Index Name] [ACD/IUPAC Name]
1-Hexanol [German] [ACD/Index Name] [ACD/IUPAC Name]
1-Hexanol [French] [ACD/Index Name] [ACD/IUPAC Name]
1-hexyl alcohol
1-Hydroxyhexane
203-852-3 [EINECS]
4-01-00-01694 [Beilstein]
Caproic alcohol
Caproyl alcohol
hexan-1-ol
hexanol [Wiki]
Hexyl alcohol
MFCD00002982 [MDL number]
n-Hexan-1-ol
n-hexanol
n-Hexyl alcohol
1-Hexan-d13-ol
1-hexanol [Portuguese] [ACD/Index Name] [ACD/IUPAC Name]
1-hexanol, purified
52598-04-6 [RN]
BNG
B-Nonylglucoside
C8E
decane, 1,3,5,7-Tetraazatricyclo(3.3.1.13,7)
Epal 6
Exxal 6
Hexalin
Hexane [ACD/Index Name] [ACD/IUPAC Name]
Hexyl alcohol203-852-3MFCD00002982
Hexylalcohol
n-C6H13OH [Formula]

Hexanol (Caproic Alcohol) is an organic alcohol with a six-carbon chain and a condensed structural formula of CH3(CH2)5OH.
Hexanol (Caproic Alcohol) colorless liquid is slightly soluble in water, but miscible with diethyl ether and ethanol.
Two additional straight chain isomers of 1-hexanol, 2-hexanol and 3-hexanol, exist, both of which differing by the location of the hydroxyl group.

CAS: 111-27-3
MF: C6H14O
MW: 102.17
EINECS: 203-852-3

Many isomeric alcohols have the formula C6H13OH.
Hexanol (Caproic Alcohol) is used in the perfume industry.
Colorless liquid.
The boiling point is 157 ° C; the relative density is 0.819.
Miscible in ethanol, propylene glycol and oil.
There are light blue shoots breath, wine, fruit and fat flavor.
Naturally occurs in some fruits such as apples, strawberries, bitter oranges, also found in camphor oil, tea leaves, tobacco leaves, eucalyptus and coffee.
Hexanol (Caproic Alcohol) appears as colorless transparent liquid with fruit-like aroma at low concentration.
Sweet; rapidly oxidized in the air; can have polymerization reaction upon contact with concentrated inorganic acid.
Similar to normal fatty aldehydes, Hexanol (Caproic Alcohol) can be oxidized to caproic acid and reduced to hexanol.

Hexanol (Caproic Alcohol) has a fruity odor and aromatic flavor.
May be synthesized by reduction of n-caproic acid; the n-hexyl alcohol represents one of the 14 possible isomers of this alcohol.
A primary alcohol that is Hexanol (Caproic Alcohol) substituted by a hydroxy group at position 1.
Hexanol (Caproic Alcohol) is an organic alcohol, which has application in the synthesis of antiseptics, fragrances, perfumes, etc.
Hexanol (Caproic Alcohol) is also used as a component of plasticizers.

Hexanol (Caproic Alcohol) Chemical Properties
Melting point: -52 °C (lit.)
Boiling point: 156-157 °C (lit.)
Density: 0.814 g/mL at 25 °C (lit.)
Vapor density: 4.5 (vs air)
Vapor pressure: 1 mm Hg ( 25.6 °C)
Refractive index: n20/D 1.418(lit.)
FEMA: 2567 | HEXYL ALCOHOL
Fp: 140 °F
Storage temp.: no restrictions.
Solubility ethanol: soluble(lit.)
Pka: 15.38±0.10(Predicted)
Form: Liquid
Color: Clear colorless
Relative polarity: 0.559
Odor: Sweet; mild.
Odor Threshold: 0.006ppm
Odor Type: herbal
Explosive limit: 1.2-7.7%(V)
Water Solubility: 6 g/L (25 ºC)
JECFA Number: 91
Merck: 14,4697
BRN: 969167
Stability: Stable. Substances to be avoided include strong acids, strong oxidizing agents. Combustible.
LogP: 1.8
CAS DataBase Reference: 111-27-3(CAS DataBase Reference)
NIST Chemistry Reference: Hexanol (Caproic Alcohol) (111-27-3)
EPA Substance Registry System: Hexanol (Caproic Alcohol) (111-27-3)

Hexanol (Caproic Alcohol) has an herbaceous, woody, fragrant, mild, sweet, green fruity odor and aromatic flavor.
Hexanol (Caproic Alcohol) is a liquid at room temperature.
The absolute perceived concentration has been reported as 0.01 ppm, and the recognition level is 0.09 ppm .

Content Analysis
Add 700 ml of newly distilled pyridine into a 1000 ml brown bottle with a glass stopper; add phthalic anhydride 11 5g with strong shaking to complete dissolution.
Take the solution 25.0ml, adding into a bottle with heat pressure resistance.
The bottle are tightly wrapped and fixed.
Weigh the sample about 1 g with the weighing pipette; add it into the pressure bottle; stamped.
The sample was fixed in a canvas bag, heated in a water bath at 98~100 ℃ for 3h, and let the water level in the water bath higher than the bottle level.

After removal, cool Hexanol (Caproic Alcohol) to room temperature; carefully open the stopper, and do not make a content loss.
Add 0.5mol/L sodium hydroxide solution 50.0ml (Note: This 50.0ml 0.5mol/L sodium hydroxide solution is not included in the final calculation).
Add 1% phenolphthalein 5 drops of pyridine solution, and then 0.5 mol/L sodium hydroxide solution to the pink end point and maintain 15 s unchanged.
At the same time carry out a blank test. Per milliliter of sodium hydroxide solution 0.5mol/L is equivalent to alcohol (C6H14O) 51.09 mg.
Or measured by non-polar column in GT-10-4 gas chromatography.

Uses
Hexanol (Caproic Alcohol) often acts as part of the head incense used in fragrance base and formulated essential oil (such as geraniol oil).
A trace of Hexanol (Caproic Alcohol) is used for violet, sweet-scented osmanthus, magnolia, ylang-type flavor to modify or increase the tender atmosphere, as well as used for edible coconut formula, berries and various types of fruit flavor.
Hexanol (Caproic Alcohol) is used as solvents and analytical reagents, also used in the pharmaceutical industry for preservatives and sleeping pills.
The goods are listed in China's GB 2760-96.

Hexanol (Caproic Alcohol) is mainly used to prepare coconut and berry flavor and used for the production of surfactants, plasticizers, fatty alcohols and so on.
Hexanol (Caproic Alcohol) is also used for chromatography reagents and organic synthesis.
Gas chromatography analysis standards.
Lithium chloride was isolated from potassium chloride and sodium chloride.
In the synthesis of spices and the preparation of caproic acid; also used as gas chromatography reagents for Wittig and Aldol reactions.
Hexanol (Caproic Alcohol) was examined as a perturbing agent on actomyosin ATPase and and was found to modulate the function of actomyosin motor via intermediate-specific structural perturbation.

Hexanol (Caproic Alcohol) is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.
Further, Hexanol (Caproic Alcohol) serves as a perturbing agent on actomyosin adenosine triphosphatease.
In addition to this, Hexanol (Caproic Alcohol) is used to modulate the function of actomyosin motor.
Hexanol (Caproic Alcohol) has been used as an odorant to study olfactory responses and to thin the dielectric layer of poly(4-vinylphenol) (PVP).

Production methods
(1) Hexanol (Caproic Alcohol) is generally derived from acetic acid reduction in industry.
Bromine butane and magnesium shards reaction obtains butyl magnesium bromide, and the butyl magnesium bromide reacted with ethylene oxide to get ethanol under laboratorial study.
(2) Via n-hexylic acid reduction.

Production Methods
Hexanol (Caproic Alcohol) is commercially prepared from the addition of ethylene to triethylaluminum followed by oxidation.
Hexanol (Caproic Alcohol) is also produced from natural products derived from coconut or palm oils.

Preparation
Hexanol (Caproic Alcohol) is produced industrially by the oligomerization of ethylene using triethylaluminium followed by oxidation of the alkylaluminium products.
An idealized synthesis is shown:

Al(C2H5)3 + 6C2H4 → Al(C6H13)3
Al(C6H13)3 + 1+1⁄2O2 + 3H2O → 3HOC6H13 + Al(OH)3
The process generates a range of oligomers that are separated by distillation.

Health Hazard
Recommended Personal Protective Equipment: Chemical gloves; chemical goggles; Symptoms Following Exposure: Liquid causes eye burns and skin irritation.
Breathing vapors is not expected to cause systemic illness; General Treatment for Exposure: In case of contact, immediately flush skin and eyes with plenty of water.
Wash eyes at least 15 min. and get medical care; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Inhalation Limits: Data not available; Toxicity by Ingestion: Grade 2, LD50 = 0.5 to 5 g/kg (rat); Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Data not available; Liquid or Solid Irritant Characteristics: Causes smarting of the skin and first-degree burns on short exposure; may cause second-degree burns on long exposure; Odor Threshold: Data not available.

Health Hazard
Vapors of Hexanol (Caproic Alcohol) are irritant to the eyesand respiratory tract.
Application of the liquid produced severe irritation in rabbits’eyes.
Hexanol (Caproic Alcohol) exhibits narcotic effects at high concentrations.
Hexanol (Caproic Alcohol) was not a skin tumor promoter when applied three times a week for 60 weeks to mice skin that had been initiated with dimethylbenz[a] anthracene.

Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Synonyms
1-Hexanol
Hexan-1-ol
Hexyl alcohol
111-27-3
HEXANOL
n-Hexanol
n-Hexyl alcohol
Amylcarbinol
1-Hydroxyhexane
1-Hexyl alcohol
Caproyl alcohol
Pentylcarbinol
Caproic alcohol
n-Hexan-1-ol
C6 alcohol
Alcohol(C6)
Hexanol (VAN)
EPAL 6
Hexyl alcohol (natural)
Alcohol C-6
Caswell No. 482E
FEMA No. 2567
FEMA Number 2567
NSC 9254
MFCD00002982
Hexanol-(1)
HSDB 565
n-Hexyl--d5 Alcohol
1-Hexanol-13C6
EINECS 203-852-3
UNII-6CP2QER8GS
6CP2QER8GS
EPA Pesticide Chemical Code 079047
BRN 0969167
AI3-08157
25917-35-5
DTXSID8021931
CHEBI:87393
NSC-9254
EINECS 247-346-0
EC 203-852-3
4-01-00-01694 (Beilstein Handbook Reference)
DTXCID201931
Hydroxyhexane
Hexanols
N-HEXYL-1,1-D2 ALCOHOL
286013-16-9
64118-18-9
CAS-111-27-3
pentilcarbinol
Amilcarbinol
Caproalcohol
Hexalcohol
HEXYL ALCOHOL, ACTIVE
n-hexylalcohol
Alcohol hexilo
1-hidroxihexano
Alcool hexylique
N-hexenol
alcohol n-hexilo
N-HEXYL-2,2,3,3,4,4,5,5,6,6,6-D11 ALCOHOL
1-hexilo alcohol
Exxal 6
2159-18-4
Hexan- 1- ol
HEXANOL-CMPD
Hexyl alcohol (8CI)
hexan - 1 - ol
Exxal 6 (Salt/Mix)
HXN (CHRIS Code)
BDBM9
1-Hexanol, 98%
Hexyl alcohol, FCC, FG
n-Hexan-1-ol, n-hexanol
1-HEXANOL [HSDB]
1-HEXANOL [MI]
n-C6H13OH
SCHEMBL1877
HEXYL ALCOHOL [FCC]
C6H13OH
HEXYL ALCOHOL [FHFI]
HEXYL ALCOHOL [INCI]
WLN: Q6
MLS001055374
UN 2282 (Salt/Mix)
BIDD:ER0298
CHEMBL14085
1-Hexanol, analytical standard
1-Hexanol, anhydrous, >=99%
NSC9254
1-Hexanol (Langkettige Alkohole)
1-Hexanol, reagent grade, 98%
Hexanol, n-; (n-Hexyl alcohol)
DTXSID001022586
HMS3039L08
BCP29486
Tox21_201335
Tox21_302953
LMFA05000117
STL282713
UN2282
AKOS009031422
HY-W032022
LS-2366
1-Hexanol, purum, >=98.0% (GC)
1-Hexyl alcohol pound>>1-Hexylalcohol
NCGC00090949-01
NCGC00090949-02
NCGC00256385-01
NCGC00258887-01
Hexanols [UN2282] [Flammable liquid]
PD158361
SMR000677945
1-Hexanol, SAJ special grade, >=99.0%
1-Hexanol, Vetec(TM) reagent grade, 98%
CS-0076046
FT-0607887
H0130
Hexyl alcohol, natural, >=98%, FCC, FG
EN300-19338
Q76933
1-Hexanol, ReagentPlus(R), >=99.5% (GC)
J-002549
F0001-0237
Z104473568
InChI=1/C6H14O/c1-2-3-4-5-6-7/h7H,2-6H2,1H

HEXAPEPTIDE-2, Nom INCI : HEXAPEPTIDE-2. Ses fonctions (INCI) : Agent éclaircissant : Eclaircit les nuances des cheveux et du teint, Agent d'entretien de la peau : Maintient la peau en bon état

HEXYL ACETATE, N° CAS : 142-92-7, Nom INCI : HEXYL ACETATE, Nom chimique : Hexyl acetate, N° EINECS/ELINCS : 205-572-7. Ses fonctions (INCI) : Agent masquant : Réduit ou inhibe l'odeur ou le goût de base du produit. Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques. Agent arômatisant : Donne un arôme au produit cosmétique

Hexasol is a clear, practically colorless, liquid.
Hexasol is characterized as a clear, colorless, and odorless liquid that finds extensive use in numerous industries, such as cosmetics and personal care products.


CAS Number: 107-41-5
EC Number: 203-489-0
MDL number: MFCD00004547
Chem/IUPAC Name: 2-Methylpentane-2,4-diol
Molecular Formula: C6H14O2 or (CH3)2COHCH2CHOHCH3



2-Methyl-2,4-Pentanediol, 2-Methylpentane-2,4-Diol, Diolane, Hexylene Glycol (2-Methyl-2,4-Pentanediol, Isol, Pinakon, MPD, Hexane-1,2-Diol, (4S)-2-Methylpentane-2,4-Diol, (4R)-2-Methylpentane-2,4-Diol, Hexasol, 2,4-dihydroxy-2-methylpentane, 2-methyl-2,4-pentanediol, 4-methyl-2,4-pentanediol, 2-methylpentane-2,4-diol, 2,4-Dihydroxy-2-methylpentane, 2-Methyl-2,4-pentanediol, 4-Methyl-2,4-pentanediol, 2-Methylpentane-2,4-diol, 2,4-Pentanediol, 2-methyl-, α,α,α'-Trimethyltrimethylene glycol, Diolane, Isol, 1,1,3-Trimethyltrimethylenediol, 2-Methyl-2,4-pentandiol, 2-Methyl-2,4-pentanediol, 2,4-Dihydroxy-2-methylpentane, 4-Methyl-2,4-pentanediol, 2-Methyl pentane-2,4-diol, 2-Methylpentan-2,4-diol, Pinakon, 4-Methyl-2,4-pentanediole, (.+/-.)-2-Methyl-2,4-pentanediol, NSC 8098, Isophthalic acid, 2-Methyl-2,4-pentanediol1,1,3-Trimethyltrimethylenediol2,4-Dihydroxy-2-methylpentane2-Methyl pentane-2,4-diol4-Methyl-2,4-pentanediolTrimethyltrimethylene glycolDiolaneIsolPinakonHexG, (2,4-dihydroxy-2-methylpentane, 2,4-pentanediol, 2-methyl-, 2-methylpentane-2,4-diol, 4-methyl-2,4-pentanediol, alpha,alpha,alpha’-trimethyltrimethylene glycol, diolane, hexylene glycol, isol, pinakon, 2,4-Pentanediol,2-methyl-, 2-Methyl-2,4-pentanediol, 2,4-Dihydroxy-2-methylpentane, Diolane, Hexylene glycol, Isol, α,α,α′-Trimethyltrimethylene glycol, 1,1,3-Trimethyltrimethylenediol, MPD, (±)-2-Methyl-2,4-pentanediol, NSC 8098, Hexasol, Isohexanediol, 99113-75-4, 2-furanmethanol, 2-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, Hexylene glycol, 2-METHYL-2,4-PENTANEDIOL, 107-41-5, 2-Methylpentane-2,4-diol, Diolane, Pinakon, 2,4-Pentanediol, 2-methyl-, 2,4-Dihydroxy-2-methylpentane, Isol, 4-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, Caswell No. 574, 2-Methyl pentane-2,4-diol, 2-Methyl-2,4-pentandiol, hexyleneglycol, HSDB 1126, UNII-KEH0A3F75J, (+-)-2-Methyl-2,4-pentanediol, NSC 8098, NSC-8098, EINECS 203-489-0, KEH0A3F75J, alpha,alpha,alpha'-Trimethyltrimethylene glycol, EPA Pesticide Chemical Code 068601, BRN 1098298, 1,3-dimethyl-3-hydroxybutanol, CCRIS 9439, DTXSID5021885, CHEBI:62995, AI3-00919, Hexylene glycol [NF], 1,3,3-trimethyl-1,3-propanediol, TRACID RUBINE 5BL, DTXCID101885, EC 203-489-0, 1,1,3-trimethyl-1,3-propanediol, 4-01-00-02565 (Beilstein Handbook Reference), Hexylene glycol (NF), 7-MethylAtracuriumDimesylate(MixtureofDiastereomers), MPD, CAS-107-41-5, 2-Methylpentan-2,4-diol, 2-Methyl-pentane-2,4-diol, 64229-01-2, MFCD00004547, Hexylene glycol, 99%, R-(-)-2-METHYL-2,4-PENTANEDIOL, 2methyl-2,4-pentanediol, Hexylene glycol, >=99%, Hexylene glycol, 99.5%, SCHEMBL19379, 1,3-Trimethyltrimethylenediol, CHEMBL2104293, NSC8098, (?)-2-Methyl-2,4-pentanediol, SVTBMSDMJJWYQN-UHFFFAOYSA-N, HMS3264E19, HY-B0903, Hexylene glycol, analytical standard, Tox21_201975, Tox21_302818, s3588, AKOS015901459, CCG-213719, WLN: QY1 & 1XQ1 & 1, NCGC00249143-01, NCGC00256494-01, NCGC00259524-01, AC-13749, AS-58339, Hexylene glycol, BioXtra, >=99% (GC), (+/-)-2-Methyl-2,4-pentanediol, MPD, FT-0605050, FT-0605756, FT-0613069, Hexylene glycol, puriss., >=99.0% (GC), M0384, (S)-(-)-2-METHYL-2,4-PENTANEDIOL, .alpha.,.alpha.'-Trimethyltrimethylene glycol, Hexylene glycol, BioUltra, >=99.0% (GC), D04439, EN300-170052, AB01563179_01, J-640306, J-660006, Q2792203, W-108748, Z1255485267, Hexylene glycol, United States Pharmacopeia (USP) Reference Standard, Diolane, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, MPD, MVD, FP17780, NSC 66498, Einecs 227-150-, 3-Methylpentanediol-2,4, 2-METHYLPENTANE-2,4-DIOL, 3-METHYL-2,4-PENTANEDIOL, 3-methyl-pentane-2,4-diol, 2,4-Pentanediol, 3-methyl-, HGL, Diolane, Isol, Pinakon, 1,1,3-Trimethyl-Triethylenediol, Diacetone Glycol, Methylamilene Glycol, 2,4-Dihydroxy-2- Methyl-Penthane, 2-Methyl-Penthane-2,4-Diol., (+-)-2-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, 2,4-Pentanediol, 2-methyl-, 2-Methyl pentane-2,4-diol, 2-Methyl-2,4-pentanediol, 4-Methyl-2,4-pentanediol, Diolane, Hexylene glycol, Isol, Pinakon, alpha,alpha,alpha'-Trimethyltrimethylene glycol, HGL, 1, 1, 3-Trimethyl-Triethylenediol, Diacetone Glycol, Methylamilene Glycol, 2, 4-Dihydroxy-2-Methyl-Penthane, 2-Methyl-Penthane-2, 4-Diol, 2-Hexyl-1,3-dioxolan-2-one, Hexylene Glycol, HG, 2,4-Dihydroxy-2-methylpentane, 2-Methyl-2,4-, pentanediol, 2-Methylpentane-2,4-diol, Pentane-2,4-, diol, 2-methyl,





Hexasol is fully miscible in water and has the chemical formula C6H14O2.
Hexasol is a compound that appears in a large number of products that are used commercially and industrially
Hexasol has a low evaporation rate and it is completely miscible with water.


Hexasol is a clear, practically colorless, liquid.
Hexasol is characterized as a clear, colorless, and odorless liquid that finds extensive use in numerous industries, such as cosmetics and personal care products.


Hexasol′s a category of glycol often utilized as a solvent, humectant, and an agent to control viscosity.
Hexasol, alternative to PG or DEG or MEG in paint formulation in lowering total VOC content.
Hexasol is a small molecular weight surfactant, widely used as an industrial coating solvent, does not cause adverse health or environmental effects.


Hexasol is an oily colorless liquid with a mild sweet odor.
Hexasol floats and mixes slowly with water.
Hexasol is an oily colorless liquid with a mild sweet odor.


It is thanks to this that Hexasol has an influence on the consistency of the product.
Hexasol is safe for pregnant women and does not cause allergies.
Hexasol is a biodegradable, colorless liquid that is miscible with water and mainly used as a solvent or coupling agent


Hexasol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.
Hexasol is fully miscible in water and has the chemical formula C6H14O2.
Hexasol is a compound that appears in a large number of products that are used commercially and industrially.


Hexasol floats and mixes slowly with water.
2-methylpentane-2,4-diol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).
Hexasol is a clear, colorless liquid.


Similar to other glycols, Hexasol's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable.
Hexasol is a synthetic substance added to many cosmetics.
Hexasol is an aroma compound and has a preservative effect.


At the same time, Hexasol is also a cleaning agent and detergent.
The most important, however, is the emulsifying property of this glycol.
Hexasol, from Solvay, is an oxygenated solvent derived from acetone which has two alcohol functions.


This speciality ingredient, Hexasol, demonstrates a low evaporation rate and is completely miscible with water.
Hexasol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.
Hexasol is famous for its excellent solvency among a wide variety of materials and is popular in skin care formulas due to its ability to improve the texture.


Hexasol has viscosity-reducing properties that allow it to thin out heavy, thick formulations and produce smooth spreadability.
Hexasol has the chemical formula C6H14O2 and is fully miscible in water.
Hexasol is an ingredient used in skincare and cosmetic products to help improve the texture and sensory feel of the formulation.


Hexasol functions as a surfactant, emulsifier, and a viscosity-reducing agent.
Hexasol, also known as 2-Methyl-2,4-pentanediol, is an organic compound that can be classified as a glycol.
Glycols are a class of alcohols that contain two hydroxyl groups, which can also be called a diols.


Hexasol is a clear, hygroscopic liquid with a mild, sweet odor.
The principal end uses of Hexasol include industrial solvent, chemical intermediate, cosmetics, excipient in pharmaceuticals, paints and coatings.
Hexasol is available in technical grade and NF grade.


Hexasol is an oxygenated solvent derived from acetone which has two alcohol functions.
Hexasol has a low evaporation rate and it is completely miscible with water.
Hexasol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.


Hexasol is 2-methyl-2,4-pentanediol.
Hexasol is used as coupling agent.
Hexasol offers low flammability and low evaporation rate.


Hexasol possesses low surface tension.
Hexasol exhibits very good solvency.
Hexasol is a clear, colorless liquid that is used in many personal care and cosmetic formulations.


Studies indicate Hexasol also exhibits antimicrobial properties.
Hexasol also goes by its chemical compound name: 2-Methyl-2,4-pentanediol.
As a raw material, Hexasol is a clear liquid.


Hexasol largely acts as a solvent, humectant, and viscosity agent.
Decades of research have established Hexasol as a safe and effective ingredient.
Hexasol dissolves other ingredients in a product and enhances its stability and texture.


In nature, Hexasol is found in the tobacco plant (Nicotiana tabacum).
For industrial purposes Hexasol is formed from the achiral reagents, diacetone alcohol, and hydrogen, producing equal amounts of enantiomeric products.
Commercial Hexasol contains > 99% 2-methyl-2,4-pentanediol and is described as a racemic mixture containing equal amounts of two enantiomers.


Hexasol is a small molecular weight surfactant.
Hexasol also has a low viscosity that makes it easier to incorporate.
The chemical formula of Hexasol is C6H14O2.


Hexasol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.
Hexasol is considered safe for use in cosmetics when used in accordance with regulations and guidelines.
Hexasol is a chemical compound used in various industries, including cosmetics and personal care products.


Hexasol serves as a solvent and a humectant in these products, helping to retain moisture and improve their texture.
Hexasol is most often synthetically produced.
Hexasol is manufactured by the condensation of 2 molecules of acetone to produce diacetone alcohol, which is further hydrogenated to produce Hexasol.


This is then purified.
Hexasol is a clear, colorless liquid chemical compound with the molecular formula C6H14O2.
Hexasol belongs to a class of chemicals known as glycols, which are often used as solvents, humectants, and chemical intermediates in various industrial applications.


Hexasol is commonly used in the cosmetic and personal care industry, where it functions as a solvent and a humectant in products like moisturisers, lotions, and hair care products.
Hexasol helps to maintain moisture and improve the texture of these products.


Additionally, Hexasol has applications in perfumes, as a fragrance fixative, and in the production of various chemicals and coatings.
Hexasol is considered safe for use in cosmetics when used in compliance with regulations and guidelines.
Hexasol is a diol (with two hydroxy groups at 2 and 4 positions), a colorless liquid with a mildly sweet odor and oily consistency.



USES and APPLICATIONS of HEXASOL:
Hexasol is a cosmetic material for FDA regulated product use.
In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products.


Additionally, Hexasol helps to decrease the skin′s surface tension, thereby facilitating the penetration of other ingredients into the skin.
Hexasol is mainly used as a solvent or coupling agent.
Hexasol is a potential substitute for glycol ethers.


Hexasol is a moisturising, and setting, agent in the manufacture of textiles and can also be found in the cosmetics industry where it is a component of fragrances and bath, hair, and soap preparations.
Hexasol also has a role as a wetting agent in pesticide formulations and is a solvent in the preparation of dyes.


Hexasol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexasol can also be used as a building block in chemical synthesis.
Hexasol is mainly used as a solvent or coupling agent.


Moreover, Hexasol acts as a reagent in the synthesis of diverse chemicals.
With regard to scientific research applications, Hexasol serves as a solvent to extract an array of compounds from plant and animal tissues.
Hexasol′s also employed as a reagent in the creation of various chemicals, including agrochemicals and fragrances.


Hexasol as a surfactant helps to cleanse and moisturize the skin as well as thinning out the formulation to improve absorption, texture and allow other ingredients to work better.
Hexasol is also used as a chemical intermediate in chemical syntheses, downhole lubricant for natural gas and oil fields, hydraulic fluid, antifreeze, fuel additive, the solvent in dyes and inks, leather and textile processing, industrial and household cleaners, and in cosmetics.


The largest end use for Hexasol is in industrial coatings, as a solvent plasticizer in varnishes, lacquers, paints, and paint strippers, accounting for about 45% of the total production.
Hexasol is often used in preservative blends that contain phenoxyethanol because it boosts the efficacy of this preservative, allowing lower amounts to be used, which reduces the risk skin will have a sensitised response.


Hexasol is mainly used as a solvent or coupling agent.
Hexasol is a potential substitute for glycol ethers.
Hexasol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.


Hexasol is a compound that appears in a large number of products that are used commercially and industrially.
Hexasol is used widely across skincare, hair care, and makeup to enhance spreadability, thin out overly thick formulas, and ensure actives are fully dissolved and dispersed.


Hexasol also has some antimicrobial effect and can enhance the efficacy of certain preservatives.
Hexasol is used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products at concentrations ranging from 0.1% – 25%.


Hexasol can also be used as a building block in chemical synthesis.
In addition to skin care, Hexasol is used in other beauty products including hair care and makeup.
Hexasol has been backed as a safe ingredient for decades with reported concentrations up to 25% in personal care products (though most skin care formulas use much lower amounts than that, especially in preservative blends).


Hexasol is a potential substitute for glycol ethers.
Hexasol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexasol can also be used as a building block in chemical synthesis.


Hexasol is also used as a chemical intermediate, which accounts for approximately 20% of its consumption, and another 10% is used on oil and natural-gas fields where it is both a down hole lubricant, and a grinding and extraction aid.
Hexasol is also employed as an antifreeze, and as a coupling agent for hydraulic fluids.


That’s why Hexasol is commonly used in many cosmetics, e.g. shampoos, shower gels, and soaps.
Thanks to Hexasol, products are better adapted to the needs of consumers and meet their expectations.
Therefore, the addition of Hexasol can turn an ordinary cosmetic into something that will be used with real pleasure.


In the realm of cosmetics and personal care products, Hexasol functions as a preservative.
Hexasol′s a humectant that aids in skin moisture retention and enhances skin texture and appearance.
Hexasol operates by forming a barrier on the skin to impede moisture loss.


Hexasol is a highly soluble advanced organic solvent, which can be used in the production of metal surface treatment agents, rust and oil removal additives, textile auxiliaries, coatings and latex paints, cosmetics, pesticides, biochemical engineering, photosensitive materials, synthetic perfumes and other fields.


Hexasol is used for pesticide stabilizer, diesel antifreezer, solvent, spicery, disinfectant,fabric penetration agent and coupler , paper and leather processing auxiliary agent, emulsifier, the additive of fuel and lubricant, etc.
Hexasol is mainly used as a solvent or coupling agent.



ALTERNATIVES OF HEXASOL:
*PROPYLENE GLYCOL,
*BUTYLENE GLYCOL,
*GLYCERIN



HOW IS HEXASOL PRODUCED?
Hexasol is formed from the achiral reagents hydrogen and diacetone alcohol.



HOW IS HEXASOL STORED AND DISTRIBUTED?
Hexasol is stored in bulk storage or stainless steel drums and is transported by tank truck.
Hexasol is classed as non-hazardous for air, sea, and road freight but is classed as an irritant.
Hexasol has a specific gravity of 0.925 and a flash point of 93 °C (closed cup).



WHAT IS HEXASOL USED FOR?
The single largest user of Hexasol is the industrial coatings industry which uses approximately 45% of the HGL produced world-wide.
Hexasol is a component in lacquers and varnishes, and is a solvent plasticiser in surface coatings.
Hexasol is also a component in both oil and water- based paints, and in paint strippers.



HEXASOL AT A GLANCE:
*Solvent that produces smooth spreadability and pleasing skin care textures
*Viscosity-reducing properties allow Hexasol to thin out heavy, thick formulations
*Shows up in a wide variety of skin care, hair care, and makeup products
*As a raw material, Hexasol is clear liquid
*Backed by decades of research as a safe ingredient



BENEFITS OF HEXASOL:
Hexasol offers several benefits in various applications, particularly in cosmetics and personal care products:

*Humectant:
Hexasol helps to retain moisture, which is essential for skin and hair health.
Hexasol can keep these products from drying out, ensuring that they remain effective and pleasant to use.

*Solvent:
Hexasol functions as a solvent, helping to dissolve and blend other ingredients in cosmetics and personal care products.
This facilitates the formulation of moisturisers, lotions, and other beauty products.

*Texture Improvement:
Hexasol can enhance the texture of skincare and hair care products, making them smoother and easier to apply.
This contributes to a more luxurious and user-friendly experience.

*Fragrance Fixative:
In the perfume industry, Hexasol is used as a fixative, helping to stabilize and prolong the scent of fragrances.
This ensures that the fragrance remains consistent and long-lasting.

*Skin-Friendly:
Hexasol is considered safe for use in cosmetics and personal care products, as it has low skin irritation potential.
Hexasol is typically well-tolerated by most individuals.

*Versatility:
Its versatility makes Hexasol suitable for a wide range of products, including moisturizers, shampoos, conditioners, and perfumes.



IS HEXASOL VEGAN?
Hexasol is considered to be a vegan ingredient as it is made synethically made from oils and natural gas.
If you are looking for a vegan product, always make sure that the other ingredients in Hexasol are vegan and that the brand is cruelty-free.



SCIENTIFIC FACTS OF HEXASOL:
Butylene Glycol, or 1,3-Butanediol, dissolves most essential oils and synthetic flavoring substances.
Butylene Glycol, Hexasol, Ethoxydiglycol and Dipropylene Glycol are glycols or glycol ethers.
Glycols are a class of alcohols that contain two hydroxyl groups which are also called a diols.



PROPERTIES OF HEXASOL:
*Purity (% by weight) : ≥ 99,5
*Appearance at 20°C : clear liquid free from suspended materials
*Density at 20°C (g/cm3) : 0,920 - 0,923
*Boiling point at 1013 Pa : 197,5°C
*Flash point (closed cup) : 97°C
*Water solubility at 20°c : complete
*Hansen Solubility Parameters at 25°C: δt = 25,2; δd = 15,8; δp = 8,4; δh = 17



WHAT IS HEXASOL USED FOR?
Hexasol serves many functional benefits in skin care, hair care, and cosmetic products.


*Skin care:
Hexasol is primarily used in skin care to improve the sensory feel and texture of the products.
Hexasol also attracts and retains moisture on the surface of the skin, keeping it hydrated and nourished.
Hexasol is often found in products like toners and cleansers


*Hair care:
Hexasol is used as a viscosity agent and solvent to improve the texture and stability of formulations.
Hexasol also acts as an emollient in shampoos and conditioners to provide hydration to the shafts


*Cosmetic products:
Hexasol works to dissolve other ingredients present in a formulation and enhance the texture of the final product.
Since it has low viscosity, Hexasol is a useful ingredient in products like foundations, primers, and concealers



WHAT DOES HEXASOL DO IN A FORMULATION?
*Humectant
*Solvent
*Viscosity controlling



WHAT ARE THE FUNCTIONS OF HEXASOL?
Hexasol is added to cosmetics and skincare products based on its functions as a surfactant, an emulsifier, and a viscosity-reducing agent.

*SURFACTANT
Surfactant is the short term for surface active agents.
Surfactants are compounds that lower the surface tension between two substances.
In skincare products, surfactants work to lift dirt, oil and fats from the skin, allowing them to be washed away.

This is possible because while one end of the surfactant molecule is attracted to water, the other end is attracted to oil.
Thus, surfactants attract the oil, dirt, and other impurities that have accumulated on your skin during the day and wash them away.
Due to these properties, Hexasol can be found in many different cleansers and body washes.


*EMULSIFIER
Hexasol also functions as an emulsifier.
An emulsifier is needed for products that contain both water and oil components, for example, when oils are added to a water-based formula.
When shaking stops, however, the two phases can start to separate.

To address this problem, an emulsifier like Hexasol can be added to the system, which helps the droplets remain dispersed and produces an even and stable formulation.

As an emulsifier, Hexasol consists of a water-loving hydrophilic head and an oil-loving hydrophobic tail.
The hydrophilic head is attracted to the water and the hydrophobic tail to the oil.
Once again, Hexasol reduces the surface tension by positioning itself between the oil and water, which has a stabilizing effect on the product.


*THINNING
Finally, Hexasol functions as a viscosity-reducing agent.
The term viscosity corresponds to the concept of “thickness”, for example, honey has a higher viscosity than water.
As a viscosity-reducing agent, Hexasol works to thin out heavy formulations and create a thinner, more spreadable product.



SAFETY PROFILE OF HEXASOL:
Hexasol is generally considered safe for use in cosmetic products.
Hexasol does not cause skin irritation and sensitization and is not known to be comedogenic.
However, as with any ingredient, some individuals may have an allergic reaction or sensitivity to it, so Hexasol is always recommended to patch test products before use.
Lastly, Hexasol is vegan and can be considered halal, but it is best to check with the supplier.



IS HEXASOL SAFE?
The safety of Hexasol has been assessed by the Cosmetic Ingredient Review Expert Panel.
The Cosmetic Ingredient Review Expert Panel is responsible for the independent evaluation of the safety and efficacy of skincare and cosmetic ingredients.
The Expert Panel evaluated the scientific data and concluded that Hexasol is safe for use in cosmetics and personal care products.



FEATURES OF HEXASOL:
*Solvent,
*intermediate



THE GOOD:
Hexasol helps to improve the texture and feel of skincare and cosmetic formulations.
Hexasol also has an added benefit of acting as a protective barrier for the skin.


THE NOT SO GOOD:
Hexasol can be a mild irritant in high concentrations.


WHO IS HEXASOL FOR?
All skin types except those that have an identified allergy to Hexasol.


SYNERGETIC INGREDIENTS:
Hexasol works well with most ingredients.


KEEP AN EYE ON:
Nothing to keep an eye on here.



ORIGIN OF HEXASOL:
Hexasol is typically synthesized by the reaction of ethylene oxide with n-butanol or by the hydration of 1,5-hexadiene.
Hexasol is later purified by distillation or other methods to obtain the final Hexasol.



PHYSICAL and CHEMICAL PROPERTIES of HEXASOL:
Molecular Weight： 118.174
Exact Mass： 118.17
EC Number： 203-489-0
ICSC Number： 0660
NSC Number： 8098
UN Number： 1993
DSSTox ID： DTXSID5021885
Color/Form： Liquid|Colorless liquid
HScode： 2905399090
PSA： 40.46000
Boiling Point: 197.5°C
Melting Point: -50°C
pH: 7.0

Solubility: Highly soluble in water
Viscosity: Low
XLogP3： 0.00
Appearance： Hexylene glycol is an oily colorless liquid with a mild sweet odor.
Floats and mixes slowly with water.
Density： 0.92 g/cm3
Melting Point：-50 °C
Boiling Point：198 °C @ Press: 760 Torr
Flash Point：93.9±0.0 °C
Refractive Index：1.447
Water Solubility：Miscible
Storage Conditions：Separated from strong oxidants and strong acids.
Vapor Pressure：0.05 mmHg

Vapor Density：
Relative vapour density (air = 1): 4.1
Flammability characteristics： Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Explosive limit： Explosive limits , vol% in air: 1.2-8.1
Odor：Mild sweetish
Henrys Law Constant：
Henry's Law constant = 4.06X10-7 atm-cu m/mol at 25 °C (est)
Experimental Properties：
Dipole moment: 2.8
Heat of formation = -5.3476X10+8 J/kmol
Triple point temperature = 223.15 °C; triple point pressure: 9.5609X10-6 Pa
Hydroxyl radical reaction rate constant = 2.77X10-11 atm-cu m/mol at 25 °C

Air and Water Reactions： Hygroscopic.
Water soluble
Reactive Group：Alcohols and Polyols
Reactivity Profile： HEXYLENE GLYCOL is incompatible with the following:
Strong oxidizers, strong acids.
Autoignition Temperature： 583 °F
Autoignition temp = 579 K|306 °C
Heat of Combustion： Standard net heat of combustion = -3.4356x10+9 J/kmol
Flammable Limits： Flammability limits = 1.3-9 vol%
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Heat of Vaporization： 13.7 kcal/mol at the boiling point
Critical Temperature & Pressure：
Critical temp = 621 K
Critical pressure = 4.01X10+6 Pa

Molecular Weight: 118.17
XLogP3-AA: 0.3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 2
Exact Mass: 118.099379685
Monoisotopic Mass: 118.099379685
Topological Polar Surface Area: 40.5 Ų
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 68.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical name (CAS): 2-methyl-2,4-pentanediol
CAS number: 107-41-5
Structural formula: CH3–CH(OH)–CH2–C(OH)(CH3)2
Molecular formula: C6H14O2
Molecular weight: 118.18
Melting point: –40°C
Boiling point: 195–200°C
Density at 20°C: 0.920–0.923 g/cm3
Vapour pressure at: 20°C 0.06 hPa
log Pow*: –0.14
CAS number: 107-41-5
EC index number: 603-053-00-3
EC number: 203-489-0
Grade: NF

Hill Formula: C₆H₁₄O₂
Molar Mass: 118.18 g/mol
HS Code: 2926 90 70
Density: 0.922 g/cm3 (20 °C)
Explosion limit: 1 - 9.9 %(V)
Flash point: 94 °C
Ignition temperature: 425 °C
Melting Point: -40 °C
pH value: 6.0 - 8.0 (118.2 g/l, H₂O, 25 °C)
Vapor pressure: 0.03 hPa (20 °C)
Physical state: liquid
Color: colorless
Odor: sweet, mild
Melting point/freezing point:
Melting point/range: -40 °C - lit.

Initial boiling point and boiling range: 197 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 7,4 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 94 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 6,0 - 8,0 at 118,2 g/l at 25 °C
Solubility:
Easily soluble in cold water.
Soluble in diethyl ether.
Soluble in alcohol, lower aliphatic hydrocarbons.
Soluble in a variety of organic solvents.
Miscible with fatty acids
Specific Gravity 20/20 °C:0.9232

Distillation Range at 760 mm Hg (IP) °C:196.4
Distillation Range at 760 mm Hg (DP) °C:198.2
Purity, % w/w:99.62
Acidity as acetic Acid, % w/w: 0.0010
Water, % w/w: 0.018
Melting point: −40 °C(lit.)
Boiling point: 197 °C(lit.)
Density: 0.925 g/mL at 25 °C(lit.)
vapor density: 4.1 (vs air)
vapor pressure: 0.02 mm Hg ( 20 °C)
refractive index: n20/D 1.427(lit.)
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 36 mPa.s at 20 °C

Water solubility ca.: 118,2 g/l at 20 °C
Partition coefficient: n-octanol/water:
log Pow: 0,58 - (Lit.), Bioaccumulation is not expected.
Vapor pressure: 0,03 hPa at 20 °C
Density: 0,925 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information
Relative vapor density: 4,08 - (Air = 1.0)
Molar Weight: 118.176g/mol
Melting Point: -40 °C
Boiling Point: 196 °C

Flash Point: 93 °C
Density: 0.925
Forms: Liquid (clear)
Chemical formula: C6H14O2
Molar mass: 118.176 g•mol−1
Appearance: colourless liquid
Odor: mild, sweetish
Density: 0.92 g/mL
Melting point: −40 °C (−40 °F; 233 K)
Boiling point: 197 °C (387 °F; 470 K)
Solubility in water: miscible[1]
Vapor pressure: 0.05 mmHg (20°C)
Flash point: 98.3 °C (208.9 °F; 371.4 K)
Explosive limits: 1.3%-7.4%
Appearance: colorless clear liquid (est)
Physical state and Appearance:Liquid.

Odor:Sweetish
Molecular Weight:118.18 g/mole
Color:Colorless
Boiling Point:197 (386.6) - 198° C
Melting Point:-50 - (-58)
Specific Gravity:0.9254 @ 17 C; 0.9234 @ 20 C (Water = 1)
Vapor Pressure: 0.05 mm of Hg (@ 20)
Vapor Density: 4.1 (Air = 1)
Odor Threshold: 50 ppm
Dispersion Properties: See solubility in water, diethyl ether
Flash point: 201 °F
storage temp.: 2-8°C
solubility: H2O: 1 M at 20 °C, clear, colorless
pka: 14.72±0.20(Predicted)
CAS DataBase Reference: 5683-44-3(CAS DataBase Reference)

Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.92400 @ 25.00 °C.
Melting Point: -40.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density: 4.1 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 0.004 (est)
Soluble in: alcohol
water, 3.256e+004 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)
Molecular Weight: 118.2 g/mol
Empirical Formula: C6H14O2

Appearance: Colorless, Liquid
Freezing Point: -50°C (-58.0°F)
Boiling Point: @ 760mm Hg 196°C (385°F)
Flash Point: Closed Cup 96°C (205°F)
Autoignition Temperature: 425°C (797°F)
Density @ 20°C: 0.924 kg/L, 7.71 lb/gal
Vapor Pressure: @ 20°C 0.05 mmHg
Evaporation Rate: (nBuAc = 1) 0.007
Solubility in Water: @ 20°C Miscible
Surface Tension @ 20°C: 33.1 dynes/cm
Refractive Index @ 20°C: 1.426
Viscosity @ 20°C: 38.9 cP
Lower Explosive Limit: 1.0 v/v%
Upper Explosive Limit: 9.9 v/v%
Conductivity @ 20°C: 3x106 pS/m

Dielectric Constant @ 20°C: ≈7.7
Specific Heat @ 20°C: 2.20 kJ/kg/°C
Heat of Vaporization @ normal boiling point: 435 kJ/kg
Heat of Combustion @ 25°C: 29875 kJ/kg
Odor Threshold: 50 ppm
Molecular Weight 118.2 g/mol
Empirical Formula C6H14O2
Appearance Colorless
Liquid
Freezing Point -50°C (-58.0°F)
Boiling Point @ 760mm Hg 196°C (385°F)
Flash Point – Closed Cup 96°C (205°F)
Autoignition Temperature 425°C (797°F)

Density @ 20°C 0.924 kg/L
7.71 lb/gal
Vapor Pressure @ 20°C 0.05 mmHg
Evaporation Rate (nBuAc = 1) 0.007
Solubility in Water @ 20°C Miscible
Surface Tension @ 20°C 33.1 dynes/cm
Refractive Index @ 20°C 1.426
Viscosity @ 20°C 38.9 cP
Lower Explosive Limit 1.0 v/v%
Upper Explosive Limit 9.9 v/v%
Conductivity @ 20°C 3x106 pS/m
Dielectric Constant @ 20°C ≈7.7
Specific Heat @ 20°C 2.20 kJ/kg/°C

Heat of Vaporization @ normal boiling point 435 kJ/kg
Heat of Combustion @ 25°C 29875 kJ/kg
Odor Threshold 50 ppm
CAS NO:107-41-5
EINECS NO:203-489-0
Molecular Formula:C6H14O2
Molecular Weight:118.1742
InChI:InChI=1/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3
Density:0.96g/cm3
Melting Point:-40ºC
Boiling Point:197.5°C at 760 mmHg
Flash Point:93.9°C
Water Solubility:soluble
Vapour Pressure:0.0961mmHg at 25°C

Refractive Rate:n20/D1.427(lit.)
Storage Condition:2-8°C
Appearance:Clear colorless Slightly Viscous Liquid
Odor:Ammonia-like
PH Value:6-8(25ºC,1MinH2O)
Explosive Limit:1-9.9%(V)
Sensitivity:Hygroscopic
Stability: Incompatible with strong oxidizing agents, strong acids,strong reducing agents.
Physical description: Colorless liquid with a mild, sweetish odor.
Boiling point: 388°F
Molecular weight: 118.2
Freezing point/melting point: -58°F (sets to glass)
Vapor pressure: 0.05 mmHg
Flash point: 209°F
Specific gravity: 0.923

Lower explosive limit (LEL): 1.3% (calc)
Upper explosive limit (UEL): 8.1% (calc)
NFPA health rating: 2
NFPA fire rating: 1
NFPA reactivity rating: 0
Appearance: colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.92400 @ 25.00 °C.
Melting Point: -40.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density: 4.1 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 0.004 (est)
Soluble in: alcohol
water, 3.256e+004 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)



FIRST AID MEASURES of HEXASOL:
-Description of first-aid measures:
*General advice
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of HEXASOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of HEXASOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of HEXASOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 240 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of HEXASOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store under inert gas.
Hygroscopic.



STABILITY and REACTIVITY of HEXASOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

Hexasol Hexylene Glycol is a clear, colorless liquid chemical compound with the molecular formula C6H14O2.
Hexasol Hexylene Glycol functions as a surfactant, emulsifier, and a viscosity-reducing agent.


CAS Number: 107-41-5
EC Number: 203-489-0
MDL number: MFCD00004547
Chem/IUPAC Name: 2-Methylpentane-2,4-diol
Molecular Formula: C6H14O2 or (CH3)2COHCH2CHOHCH3



2-Methyl-2,4-Pentanediol, 2-Methylpentane-2,4-Diol, Diolane, Hexylene Glycol (2-Methyl-2,4-Pentanediol, Isol, Pinakon, MPD, Hexane-1,2-Diol, (4S)-2-Methylpentane-2,4-Diol, (4R)-2-Methylpentane-2,4-Diol, Hexasol, 2,4-dihydroxy-2-methylpentane, 2-methyl-2,4-pentanediol, 4-methyl-2,4-pentanediol, 2-methylpentane-2,4-diol, 2,4-Dihydroxy-2-methylpentane, 2-Methyl-2,4-pentanediol, 4-Methyl-2,4-pentanediol, 2-Methylpentane-2,4-diol, 2,4-Pentanediol, 2-methyl-, α,α,α'-Trimethyltrimethylene glycol, Diolane, Isol, 1,1,3-Trimethyltrimethylenediol, 2-Methyl-2,4-pentandiol, 2-Methyl-2,4-pentanediol, 2,4-Dihydroxy-2-methylpentane, 4-Methyl-2,4-pentanediol, 2-Methyl pentane-2,4-diol, 2-Methylpentan-2,4-diol, Pinakon, 4-Methyl-2,4-pentanediole, (.+/-.)-2-Methyl-2,4-pentanediol, NSC 8098, Isophthalic acid, 2-Methyl-2,4-pentanediol1,1,3-Trimethyltrimethylenediol2,4-Dihydroxy-2-methylpentane2-Methyl pentane-2,4-diol4-Methyl-2,4-pentanediolTrimethyltrimethylene glycolDiolaneIsolPinakonHexG, (2,4-dihydroxy-2-methylpentane, 2,4-pentanediol, 2-methyl-, 2-methylpentane-2,4-diol, 4-methyl-2,4-pentanediol, alpha,alpha,alpha’-trimethyltrimethylene glycol, diolane, hexylene glycol, isol, pinakon, 2,4-Pentanediol,2-methyl-, 2-Methyl-2,4-pentanediol, 2,4-Dihydroxy-2-methylpentane, Diolane, Hexylene glycol, Isol, α,α,α′-Trimethyltrimethylene glycol, 1,1,3-Trimethyltrimethylenediol, MPD, (±)-2-Methyl-2,4-pentanediol, NSC 8098, Hexasol, Isohexanediol, 99113-75-4, 2-furanmethanol, 2-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, Hexylene glycol, 2-METHYL-2,4-PENTANEDIOL, 107-41-5, 2-Methylpentane-2,4-diol, Diolane, Pinakon, 2,4-Pentanediol, 2-methyl-, 2,4-Dihydroxy-2-methylpentane, Isol, 4-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, Caswell No. 574, 2-Methyl pentane-2,4-diol, 2-Methyl-2,4-pentandiol, hexyleneglycol, HSDB 1126, UNII-KEH0A3F75J, (+-)-2-Methyl-2,4-pentanediol, NSC 8098, NSC-8098, EINECS 203-489-0, KEH0A3F75J, alpha,alpha,alpha'-Trimethyltrimethylene glycol, EPA Pesticide Chemical Code 068601, BRN 1098298, 1,3-dimethyl-3-hydroxybutanol, CCRIS 9439, DTXSID5021885, CHEBI:62995, AI3-00919, Hexylene glycol [NF], 1,3,3-trimethyl-1,3-propanediol, TRACID RUBINE 5BL, DTXCID101885, EC 203-489-0, 1,1,3-trimethyl-1,3-propanediol, 4-01-00-02565 (Beilstein Handbook Reference), Hexylene glycol (NF), 7-MethylAtracuriumDimesylate(MixtureofDiastereomers), MPD, CAS-107-41-5, 2-Methylpentan-2,4-diol, 2-Methyl-pentane-2,4-diol, 64229-01-2, MFCD00004547, Hexylene glycol, 99%, R-(-)-2-METHYL-2,4-PENTANEDIOL, 2methyl-2,4-pentanediol, Hexylene glycol, >=99%, Hexylene glycol, 99.5%, SCHEMBL19379, 1,3-Trimethyltrimethylenediol, CHEMBL2104293, NSC8098, (?)-2-Methyl-2,4-pentanediol, SVTBMSDMJJWYQN-UHFFFAOYSA-N, HMS3264E19, HY-B0903, Hexylene glycol, analytical standard, Tox21_201975, Tox21_302818, s3588, AKOS015901459, CCG-213719, WLN: QY1 & 1XQ1 & 1, NCGC00249143-01, NCGC00256494-01, NCGC00259524-01, AC-13749, AS-58339, Hexylene glycol, BioXtra, >=99% (GC), (+/-)-2-Methyl-2,4-pentanediol, MPD, FT-0605050, FT-0605756, FT-0613069, Hexylene glycol, puriss., >=99.0% (GC), M0384, (S)-(-)-2-METHYL-2,4-PENTANEDIOL, .alpha.,.alpha.'-Trimethyltrimethylene glycol, Hexylene glycol, BioUltra, >=99.0% (GC), D04439, EN300-170052, AB01563179_01, J-640306, J-660006, Q2792203, W-108748, Z1255485267, Hexylene glycol, United States Pharmacopeia (USP) Reference Standard, Diolane, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, MPD, MVD, FP17780, NSC 66498, Einecs 227-150-, 3-Methylpentanediol-2,4, 2-METHYLPENTANE-2,4-DIOL, 3-METHYL-2,4-PENTANEDIOL, 3-methyl-pentane-2,4-diol, 2,4-Pentanediol, 3-methyl-, HGL, Diolane, Isol, Pinakon, 1,1,3-Trimethyl-Triethylenediol, Diacetone Glycol, Methylamilene Glycol, 2,4-Dihydroxy-2- Methyl-Penthane, 2-Methyl-Penthane-2,4-Diol., (+-)-2-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, 2,4-Pentanediol, 2-methyl-, 2-Methyl pentane-2,4-diol, 2-Methyl-2,4-pentanediol, 4-Methyl-2,4-pentanediol, Diolane, Hexylene glycol, Isol, Pinakon, alpha,alpha,alpha'-Trimethyltrimethylene glycol, HGL, 1, 1, 3-Trimethyl-Triethylenediol, Diacetone Glycol, Methylamilene Glycol, 2, 4-Dihydroxy-2-Methyl-Penthane, 2-Methyl-Penthane-2, 4-Diol, 2-Hexyl-1,3-dioxolan-2-one, Hexylene Glycol, HG, 2,4-Dihydroxy-2-methylpentane, 2-Methyl-2,4-, pentanediol, 2-Methylpentane-2,4-diol, Pentane-2,4-, diol, 2-methyl,



Hexasol Hexylene Glycol, from Solvay, is an oxygenated solvent derived from acetone which has two alcohol functions.
This speciality ingredient, Hexasol Hexylene Glycol, demonstrates a low evaporation rate and is completely miscible with water.
Hexasol Hexylene Glycol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.


Hexasol Hexylene Glycol has the chemical formula C6H14O2 and is fully miscible in water.
Hexasol Hexylene Glycol is an ingredient used in skincare and cosmetic products to help improve the texture and sensory feel of the formulation.
Hexasol Hexylene Glycol functions as a surfactant, emulsifier, and a viscosity-reducing agent.


Hexasol Hexylene Glycol, also known as 2-Methyl-2,4-pentanediol, is an organic compound that can be classified as a glycol.
Glycols are a class of alcohols that contain two hydroxyl groups, which can also be called a diols.
Hexasol Hexylene Glycol is a clear, hygroscopic liquid with a mild, sweet odor.


Hexasol Hexylene Glycol is most often synthetically produced.
Hexasol Hexylene Glycol is manufactured by the condensation of 2 molecules of acetone to produce diacetone alcohol, which is further hydrogenated to produce Hexasol Hexylene Glycol.


This is then purified.
Hexasol Hexylene Glycol is a clear, colorless liquid chemical compound with the molecular formula C6H14O2.
Hexasol Hexylene Glycol belongs to a class of chemicals known as glycols, which are often used as solvents, humectants, and chemical intermediates in various industrial applications.


Hexasol Hexylene Glycol is commonly used in the cosmetic and personal care industry, where it functions as a solvent and a humectant in products like moisturisers, lotions, and hair care products.
Hexasol Hexylene Glycol helps to maintain moisture and improve the texture of these products.


Hexasol Hexylene Glycol is considered safe for use in cosmetics when used in accordance with regulations and guidelines.
Hexasol Hexylene Glycol is a chemical compound used in various industries, including cosmetics and personal care products.
Hexasol Hexylene Glycol serves as a solvent and a humectant in these products, helping to retain moisture and improve their texture.


Additionally, Hexasol Hexylene Glycol has applications in perfumes, as a fragrance fixative, and in the production of various chemicals and coatings.
Hexasol Hexylene Glycol is considered safe for use in cosmetics when used in compliance with regulations and guidelines.
Hexasol Hexylene Glycol is a diol (with two hydroxy groups at 2 and 4 positions), a colorless liquid with a mildly sweet odor and oily consistency.


In nature, Hexasol Hexylene Glycol is found in the tobacco plant (Nicotiana tabacum).
For industrial purposes Hexasol Hexylene Glycol is formed from the achiral reagents, diacetone alcohol, and hydrogen, producing equal amounts of enantiomeric products.


Commercial Hexasol Hexylene Glycol contains > 99% 2-methyl-2,4-pentanediol and is described as a racemic mixture containing equal amounts of two enantiomers.
Hexasol Hexylene Glycol is a small molecular weight surfactant.


Hexasol Hexylene Glycol is famous for its excellent solvency among a wide variety of materials and is popular in skin care formulas due to its ability to improve the texture.
Hexasol Hexylene Glycol has viscosity-reducing properties that allow it to thin out heavy, thick formulations and produce smooth spreadability.


Studies indicate Hexasol Hexylene Glycol also exhibits antimicrobial properties.
Hexasol Hexylene Glycol also goes by its chemical compound name: 2-Methyl-2,4-pentanediol.
As a raw material, Hexasol Hexylene Glycol is a clear liquid.


Similar to other glycols, Hexasol Hexylene Glycol's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable.
Hexasol Hexylene Glycol is a synthetic substance added to many cosmetics.


Hexasol Hexylene Glycol is an aroma compound and has a preservative effect.
At the same time, Hexasol Hexylene Glycol is also a cleaning agent and detergent.
The most important, however, is the emulsifying property of this glycol.


It is thanks to this that Hexasol Hexylene Glycol has an influence on the consistency of the product.
Hexasol Hexylene Glycol is safe for pregnant women and does not cause allergies.
Hexasol Hexylene Glycol is a biodegradable, colorless liquid that is miscible with water and mainly used as a solvent or coupling agent


Hexasol Hexylene Glycol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.
Hexasol Hexylene Glycol is fully miscible in water and has the chemical formula C6H14O2.
Hexasol Hexylene Glycol is a compound that appears in a large number of products that are used commercially and industrially.


Hexasol Hexylene Glycol is a clear, practically colorless, liquid.
Hexasol Hexylene Glycol is characterized as a clear, colorless, and odorless liquid that finds extensive use in numerous industries, such as cosmetics and personal care products.


Hexasol Hexylene Glycol′s a category of glycol often utilized as a solvent, humectant, and an agent to control viscosity.
Hexasol Hexylene Glycol, alternative to PG or DEG or MEG in paint formulation in lowering total VOC content.
Hexasol Hexylene Glycol is a small molecular weight surfactant, widely used as an industrial coating solvent, does not cause adverse health or environmental effects.


Hexasol Hexylene Glycol is an oily colorless liquid with a mild sweet odor.
Hexasol Hexylene Glycol floats and mixes slowly with water.
Hexasol Hexylene Glycol is an oily colorless liquid with a mild sweet odor.


Hexasol Hexylene Glycol floats and mixes slowly with water.
|2-methylpentane-2,4-diol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).
Hexasol Hexylene Glycol is a clear, colorless liquid.


The principal end uses of Hexasol Hexylene Glycol include industrial solvent, chemical intermediate, cosmetics, excipient in pharmaceuticals, paints and coatings.
Hexasol Hexylene Glycol is available in technical grade and NF grade.


Hexasol Hexylene Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
Hexasol Hexylene Glycol has a low evaporation rate and it is completely miscible with water.
Hexasol Hexylene Glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.


Hexasol Hexylene Glycol is 2-methyl-2,4-pentanediol.
Hexasol Hexylene Glycol is used as coupling agent.
Hexasol Hexylene Glycol offers low flammability and low evaporation rate.


Hexasol Hexylene Glycol possesses low surface tension.
Hexasol Hexylene Glycol exhibits very good solvency.
Hexasol Hexylene Glycol is a clear, colorless liquid that is used in many personal care and cosmetic formulations.


Hexasol Hexylene Glycol largely acts as a solvent, humectant, and viscosity agent.
Decades of research have established Hexasol Hexylene Glycol as a safe and effective ingredient.
Hexasol Hexylene Glycol dissolves other ingredients in a product and enhances its stability and texture.


Hexasol Hexylene Glycol also has a low viscosity that makes it easier to incorporate.
The chemical formula of Hexasol Hexylene Glycol is C6H14O2.
Hexasol Hexylene Glycol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.


Hexasol Hexylene Glycol is fully miscible in water and has the chemical formula C6H14O2.
Hexasol Hexylene Glycol is a compound that appears in a large number of products that are used commercially and industrially
Hexasol Hexylene Glycol has a low evaporation rate and it is completely miscible with water.



USES and APPLICATIONS of HEXASOL HEXYLENE GLYCOL:
Hexasol Hexylene Glycol is a compound that appears in a large number of products that are used commercially and industrially.
Hexasol Hexylene Glycol is used widely across skincare, hair care, and makeup to enhance spreadability, thin out overly thick formulas, and ensure actives are fully dissolved and dispersed.


Hexasol Hexylene Glycol also has some antimicrobial effect and can enhance the efficacy of certain preservatives.
Hexasol Hexylene Glycol is used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products at concentrations ranging from 0.1% – 25%.


Hexasol Hexylene Glycol as a surfactant helps to cleanse and moisturize the skin as well as thinning out the formulation to improve absorption, texture and allow other ingredients to work better.
Hexasol Hexylene Glycol is also used as a chemical intermediate in chemical syntheses, downhole lubricant for natural gas and oil fields, hydraulic fluid, antifreeze, fuel additive, the solvent in dyes and inks, leather and textile processing, industrial and household cleaners, and in cosmetics.


The largest end use for Hexasol Hexylene Glycol is in industrial coatings, as a solvent plasticizer in varnishes, lacquers, paints, and paint strippers, accounting for about 45% of the total production.
Hexasol Hexylene Glycol is often used in preservative blends that contain phenoxyethanol because it boosts the efficacy of this preservative, allowing lower amounts to be used, which reduces the risk skin will have a sensitised response.


Hexasol Hexylene Glycol is mainly used as a solvent or coupling agent.
Hexasol Hexylene Glycol is a potential substitute for glycol ethers.
Hexasol Hexylene Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.


Hexasol Hexylene Glycol can also be used as a building block in chemical synthesis.
In addition to skin care, Hexasol Hexylene Glycol is used in other beauty products including hair care and makeup.
Hexasol Hexylene Glycol has been backed as a safe ingredient for decades with reported concentrations up to 25% in personal care products (though most skin care formulas use much lower amounts than that, especially in preservative blends).


That’s why Hexasol Hexylene Glycol is commonly used in many cosmetics, e.g. shampoos, shower gels, and soaps.
Thanks to Hexasol Hexylene Glycol, products are better adapted to the needs of consumers and meet their expectations.
Therefore, the addition of Hexasol Hexylene Glycol can turn an ordinary cosmetic into something that will be used with real pleasure.


Hexasol Hexylene Glycol is a cosmetic material for FDA regulated product use.
In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products.


Moreover, Hexasol Hexylene Glycol acts as a reagent in the synthesis of diverse chemicals.
With regard to scientific research applications, Hexasol Hexylene Glycol serves as a solvent to extract an array of compounds from plant and animal tissues.
Hexasol Hexylene Glycol′s also employed as a reagent in the creation of various chemicals, including agrochemicals and fragrances.


In the realm of cosmetics and personal care products, Hexasol Hexylene Glycol functions as a preservative.
Hexasol Hexylene Glycol′s a humectant that aids in skin moisture retention and enhances skin texture and appearance.
Hexasol Hexylene Glycol operates by forming a barrier on the skin to impede moisture loss.


Additionally, Hexasol Hexylene Glycol helps to decrease the skin′s surface tension, thereby facilitating the penetration of other ingredients into the skin.
Hexasol Hexylene Glycol is mainly used as a solvent or coupling agent.
Hexasol Hexylene Glycol is a potential substitute for glycol ethers.


Hexasol Hexylene Glycol is a highly soluble advanced organic solvent, which can be used in the production of metal surface treatment agents, rust and oil removal additives, textile auxiliaries, coatings and latex paints, cosmetics, pesticides, biochemical engineering, photosensitive materials, synthetic perfumes and other fields.


Hexasol Hexylene Glycol is used for pesticide stabilizer, diesel antifreezer, solvent, spicery, disinfectant,fabric penetration agent and coupler , paper and leather processing auxiliary agent, emulsifier, the additive of fuel and lubricant, etc.
Hexasol Hexylene Glycol is mainly used as a solvent or coupling agent.


Hexasol Hexylene Glycol is a potential substitute for glycol ethers.
Hexasol Hexylene Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexasol Hexylene Glycol can also be used as a building block in chemical synthesis.


Hexasol Hexylene Glycol is also used as a chemical intermediate, which accounts for approximately 20% of its consumption, and another 10% is used on oil and natural-gas fields where it is both a down hole lubricant, and a grinding and extraction aid.
Hexasol Hexylene Glycol is also employed as an antifreeze, and as a coupling agent for hydraulic fluids.


Hexasol Hexylene Glycol is a moisturising, and setting, agent in the manufacture of textiles and can also be found in the cosmetics industry where it is a component of fragrances and bath, hair, and soap preparations.
Hexasol Hexylene Glycol also has a role as a wetting agent in pesticide formulations and is a solvent in the preparation of dyes.


Hexasol Hexylene Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexasol Hexylene Glycol can also be used as a building block in chemical synthesis.
Hexasol Hexylene Glycol is mainly used as a solvent or coupling agent.



WHAT IS HEXASOL HEXYLENE GLYCOL USED FOR?
Hexasol Hexylene Glycol serves many functional benefits in skin care, hair care, and cosmetic products.

*Skin care:
Hexasol Hexylene Glycol is primarily used in skin care to improve the sensory feel and texture of the products.
Hexasol Hexylene Glycol also attracts and retains moisture on the surface of the skin, keeping it hydrated and nourished.
Hexasol Hexylene Glycol is often found in products like toners and cleansers


*Hair care:
Hexasol Hexylene Glycol is used as a viscosity agent and solvent to improve the texture and stability of formulations.
Hexasol Hexylene Glycol also acts as an emollient in shampoos and conditioners to provide hydration to the shafts


*Cosmetic products:
Hexasol Hexylene Glycol works to dissolve other ingredients present in a formulation and enhance the texture of the final product.
Since it has low viscosity, Hexasol Hexylene Glycol is a useful ingredient in products like foundations, primers, and concealers



ORIGIN OF HEXASOL HEXYLENE GLYCOL:
Hexasol Hexylene Glycol is typically synthesized by the reaction of ethylene oxide with n-butanol or by the hydration of 1,5-hexadiene.
Hexasol Hexylene Glycol is later purified by distillation or other methods to obtain the final Hexasol Hexylene Glycol.



WHAT DOES HEXASOL HEXYLENE GLYCOL DO IN A FORMULATION?
*Humectant
*Solvent
*Viscosity controlling



SAFETY PROFILE OF HEXASOL HEXYLENE GLYCOL:
Hexasol Hexylene Glycol is generally considered safe for use in cosmetic products.
Hexasol Hexylene Glycol does not cause skin irritation and sensitization and is not known to be comedogenic.
However, as with any ingredient, some individuals may have an allergic reaction or sensitivity to it, so Hexasol Hexylene Glycol is always recommended to patch test products before use.
Lastly, Hexasol Hexylene Glycol is vegan and can be considered halal, but it is best to check with the supplier.



ALTERNATIVES OF HEXASOL HEXYLENE GLYCOL:
*PROPYLENE GLYCOL,
*BUTYLENE GLYCOL,
*GLYCERIN



HOW IS HEXASOL HEXYLENE GLYCOL PRODUCED?
Hexasol Hexylene Glycol is formed from the achiral reagents hydrogen and diacetone alcohol.



HOW IS HEXASOL HEXYLENE GLYCOL STORED AND DISTRIBUTED?
Hexasol Hexylene Glycol is stored in bulk storage or stainless steel drums and is transported by tank truck.
Hexasol Hexylene Glycol is classed as non-hazardous for air, sea, and road freight but is classed as an irritant.
Hexasol Hexylene Glycol has a specific gravity of 0.925 and a flash point of 93 °C (closed cup).



WHAT IS HEXASOL HEXYLENE GLYCOL USED FOR?
The single largest user of Hexasol Hexylene Glycol is the industrial coatings industry which uses approximately 45% of the HGL produced world-wide.
Hexasol Hexylene Glycol is a component in lacquers and varnishes, and is a solvent plasticiser in surface coatings.
Hexasol Hexylene Glycol is also a component in both oil and water- based paints, and in paint strippers.



HEXASOL HEXYLENE GLYCOL AT A GLANCE:
*Solvent that produces smooth spreadability and pleasing skin care textures
*Viscosity-reducing properties allow Hexasol Hexylene Glycol to thin out heavy, thick formulations
*Shows up in a wide variety of skin care, hair care, and makeup products
*As a raw material, Hexasol Hexylene Glycol is clear liquid
*Backed by decades of research as a safe ingredient



BENEFITS OF HEXASOL HEXYLENE GLYCOL:
Hexasol Hexylene Glycol offers several benefits in various applications, particularly in cosmetics and personal care products:

*Humectant:
Hexasol Hexylene Glycol helps to retain moisture, which is essential for skin and hair health.
Hexasol Hexylene Glycol can keep these products from drying out, ensuring that they remain effective and pleasant to use.

*Solvent:
Hexasol Hexylene Glycol functions as a solvent, helping to dissolve and blend other ingredients in cosmetics and personal care products.
This facilitates the formulation of moisturisers, lotions, and other beauty products.

*Texture Improvement:
Hexasol Hexylene Glycol can enhance the texture of skincare and hair care products, making them smoother and easier to apply.
This contributes to a more luxurious and user-friendly experience.

*Fragrance Fixative:
In the perfume industry, Hexasol Hexylene Glycol is used as a fixative, helping to stabilize and prolong the scent of fragrances.
This ensures that the fragrance remains consistent and long-lasting.

*Skin-Friendly:
Hexasol Hexylene Glycol is considered safe for use in cosmetics and personal care products, as it has low skin irritation potential.
Hexasol Hexylene Glycol is typically well-tolerated by most individuals.

*Versatility:
Its versatility makes Hexasol Hexylene Glycol suitable for a wide range of products, including moisturizers, shampoos, conditioners, and perfumes.



IS HEXASOL HEXYLENE GLYCOL SAFE?
The safety of Hexasol Hexylene Glycol has been assessed by the Cosmetic Ingredient Review Expert Panel.
The Cosmetic Ingredient Review Expert Panel is responsible for the independent evaluation of the safety and efficacy of skincare and cosmetic ingredients.
The Expert Panel evaluated the scientific data and concluded that Hexasol Hexylene Glycol is safe for use in cosmetics and personal care products.



FEATURES OF HEXASOL HEXYLENE GLYCOL:
*Solvent,
*intermediate



THE GOOD:
Hexasol Hexylene Glycol helps to improve the texture and feel of skincare and cosmetic formulations.
Hexasol Hexylene Glycol also has an added benefit of acting as a protective barrier for the skin.


THE NOT SO GOOD:
Hexasol Hexylene Glycol can be a mild irritant in high concentrations.


WHO IS HEXASOL HEXYLENE GLYCOL FOR?
All skin types except those that have an identified allergy to Hexasol Hexylene Glycol.


SYNERGETIC INGREDIENTS:
Hexasol Hexylene Glycol works well with most ingredients.


KEEP AN EYE ON:
Nothing to keep an eye on here.



WHAT ARE THE FUNCTIONS OF HEXASOL HEXYLENE GLYCOL?
Hexasol Hexylene Glycol is added to cosmetics and skincare products based on its functions as a surfactant, an emulsifier, and a viscosity-reducing agent.

*SURFACTANT
Surfactant is the short term for surface active agents.
Surfactants are compounds that lower the surface tension between two substances.
In skincare products, surfactants work to lift dirt, oil and fats from the skin, allowing them to be washed away.

This is possible because while one end of the surfactant molecule is attracted to water, the other end is attracted to oil.
Thus, surfactants attract the oil, dirt, and other impurities that have accumulated on your skin during the day and wash them away.
Due to these properties, Hexasol Hexylene Glycol can be found in many different cleansers and body washes.


*EMULSIFIER
Hexasol Hexylene Glycol also functions as an emulsifier.
An emulsifier is needed for products that contain both water and oil components, for example, when oils are added to a water-based formula.

According to EFEMA, when water and oil are mixed together and vigorously shaken, a dispersion of oil droplets in water is formed.
When shaking stops, however, the two phases can start to separate.

To address this problem, an emulsifier like Hexasol Hexylene Glycol can be added to the system, which helps the droplets remain dispersed and produces an even and stable formulation.

As an emulsifier, Hexasol Hexylene Glycol consists of a water-loving hydrophilic head and an oil-loving hydrophobic tail.
The hydrophilic head is attracted to the water and the hydrophobic tail to the oil.
Once again, Hexasol Hexylene Glycol reduces the surface tension by positioning itself between the oil and water, which has a stabilizing effect on the product.


*THINNING
Finally, Hexasol Hexylene Glycol functions as a viscosity-reducing agent.
The term viscosity corresponds to the concept of “thickness”, for example, honey has a higher viscosity than water.
As a viscosity-reducing agent, Hexasol Hexylene Glycol works to thin out heavy formulations and create a thinner, more spreadable product.



IS HEXASOL HEXYLENE GLYCOL VEGAN?
Hexasol Hexylene Glycol is considered to be a vegan ingredient as it is made synethically made from oils and natural gas.
If you are looking for a vegan product, always make sure that the other ingredients in Hexasol Hexylene Glycol are vegan and that the brand is cruelty-free.



SCIENTIFIC FACTS OF HEXASOL HEXYLENE GLYCOL:
Butylene Glycol, or 1,3-Butanediol, dissolves most essential oils and synthetic flavoring substances.
Butylene Glycol, Hexasol Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are glycols or glycol ethers.
Glycols are a class of alcohols that contain two hydroxyl groups which are also called a diols.



PROPERTIES OF HEXASOL HEXYLENE GLYCOL:
*Purity (% by weight) : ≥ 99,5
*Appearance at 20°C : clear liquid free from suspended materials
*Density at 20°C (g/cm3) : 0,920 - 0,923
*Boiling point at 1013 Pa : 197,5°C
*Flash point (closed cup) : 97°C
*Water solubility at 20°c : complete
*Hansen Solubility Parameters at 25°C: δt = 25,2; δd = 15,8; δp = 8,4; δh = 17



PHYSICAL and CHEMICAL PROPERTIES of HEXASOL HEXYLENE GLYCOL:
Molecular Weight： 118.174
Exact Mass： 118.17
EC Number： 203-489-0
ICSC Number： 0660
NSC Number： 8098
UN Number： 1993
DSSTox ID： DTXSID5021885
Color/Form： Liquid|Colorless liquid
HScode： 2905399090
PSA： 40.46000
Boiling Point: 197.5°C
Melting Point: -50°C
pH: 7.0

Solubility: Highly soluble in water
Viscosity: Low
XLogP3： 0.00
Appearance： Hexylene glycol is an oily colorless liquid with a mild sweet odor.
Floats and mixes slowly with water.
Density： 0.92 g/cm3
Melting Point：-50 °C
Boiling Point：198 °C @ Press: 760 Torr
Flash Point：93.9±0.0 °C
Refractive Index：1.447
Water Solubility：Miscible
Storage Conditions：Separated from strong oxidants and strong acids.
Vapor Pressure：0.05 mmHg

Vapor Density：
Relative vapour density (air = 1): 4.1
Flammability characteristics： Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Explosive limit： Explosive limits , vol% in air: 1.2-8.1
Odor：Mild sweetish
Henrys Law Constant：
Henry's Law constant = 4.06X10-7 atm-cu m/mol at 25 °C (est)
Experimental Properties：
Dipole moment: 2.8
Heat of formation = -5.3476X10+8 J/kmol
Triple point temperature = 223.15 °C; triple point pressure: 9.5609X10-6 Pa
Hydroxyl radical reaction rate constant = 2.77X10-11 atm-cu m/mol at 25 °C

Air and Water Reactions： Hygroscopic.
Water soluble
Reactive Group：Alcohols and Polyols
Reactivity Profile： HEXYLENE GLYCOL is incompatible with the following:
Strong oxidizers, strong acids.
Autoignition Temperature： 583 °F
Autoignition temp = 579 K|306 °C
Heat of Combustion： Standard net heat of combustion = -3.4356x10+9 J/kmol
Flammable Limits： Flammability limits = 1.3-9 vol%
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Heat of Vaporization： 13.7 kcal/mol at the boiling point
Critical Temperature & Pressure：
Critical temp = 621 K
Critical pressure = 4.01X10+6 Pa

Molecular Weight: 118.17
XLogP3-AA: 0.3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 2
Exact Mass: 118.099379685
Monoisotopic Mass: 118.099379685
Topological Polar Surface Area: 40.5 Ų
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 68.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical name (CAS): 2-methyl-2,4-pentanediol
CAS number: 107-41-5
Structural formula: CH3–CH(OH)–CH2–C(OH)(CH3)2
Molecular formula: C6H14O2
Molecular weight: 118.18
Melting point: –40°C
Boiling point: 195–200°C
Density at 20°C: 0.920–0.923 g/cm3
Vapour pressure at: 20°C 0.06 hPa
log Pow*: –0.14
CAS number: 107-41-5
EC index number: 603-053-00-3
EC number: 203-489-0
Grade: NF

Hill Formula: C₆H₁₄O₂
Molar Mass: 118.18 g/mol
HS Code: 2926 90 70
Density: 0.922 g/cm3 (20 °C)
Explosion limit: 1 - 9.9 %(V)
Flash point: 94 °C
Ignition temperature: 425 °C
Melting Point: -40 °C
pH value: 6.0 - 8.0 (118.2 g/l, H₂O, 25 °C)
Vapor pressure: 0.03 hPa (20 °C)
Physical state: liquid
Color: colorless
Odor: sweet, mild
Melting point/freezing point:
Melting point/range: -40 °C - lit.

Initial boiling point and boiling range: 197 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 7,4 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 94 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 6,0 - 8,0 at 118,2 g/l at 25 °C
Solubility:
Easily soluble in cold water.
Soluble in diethyl ether.
Soluble in alcohol, lower aliphatic hydrocarbons.
Soluble in a variety of organic solvents.
Miscible with fatty acids
Specific Gravity 20/20 °C:0.9232

Distillation Range at 760 mm Hg (IP) °C:196.4
Distillation Range at 760 mm Hg (DP) °C:198.2
Purity, % w/w:99.62
Acidity as acetic Acid, % w/w: 0.0010
Water, % w/w: 0.018
Melting point: −40 °C(lit.)
Boiling point: 197 °C(lit.)
Density: 0.925 g/mL at 25 °C(lit.)
vapor density: 4.1 (vs air)
vapor pressure: 0.02 mm Hg ( 20 °C)
refractive index: n20/D 1.427(lit.)
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 36 mPa.s at 20 °C

Water solubility ca.: 118,2 g/l at 20 °C
Partition coefficient: n-octanol/water:
log Pow: 0,58 - (Lit.), Bioaccumulation is not expected.
Vapor pressure: 0,03 hPa at 20 °C
Density: 0,925 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information
Relative vapor density: 4,08 - (Air = 1.0)
Molar Weight: 118.176g/mol
Melting Point: -40 °C
Boiling Point: 196 °C

Flash Point: 93 °C
Density: 0.925
Forms: Liquid (clear)
Chemical formula: C6H14O2
Molar mass: 118.176 g·mol−1
Appearance: colourless liquid
Odor: mild, sweetish
Density: 0.92 g/mL
Melting point: −40 °C (−40 °F; 233 K)
Boiling point: 197 °C (387 °F; 470 K)
Solubility in water: miscible[1]
Vapor pressure: 0.05 mmHg (20°C)
Flash point: 98.3 °C (208.9 °F; 371.4 K)
Explosive limits: 1.3%-7.4%
Appearance: colorless clear liquid (est)
Physical state and Appearance:Liquid.

Odor:Sweetish
Molecular Weight:118.18 g/mole
Color:Colorless
Boiling Point:197 (386.6) - 198° C
Melting Point:-50 - (-58)
Specific Gravity:0.9254 @ 17 C; 0.9234 @ 20 C (Water = 1)
Vapor Pressure: 0.05 mm of Hg (@ 20)
Vapor Density: 4.1 (Air = 1)
Odor Threshold: 50 ppm
Dispersion Properties: See solubility in water, diethyl ether
Flash point: 201 °F
storage temp.: 2-8°C
solubility: H2O: 1 M at 20 °C, clear, colorless
pka: 14.72±0.20(Predicted)
CAS DataBase Reference: 5683-44-3(CAS DataBase Reference)

Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.92400 @ 25.00 °C.
Melting Point: -40.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density: 4.1 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 0.004 (est)
Soluble in: alcohol
water, 3.256e+004 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)
Molecular Weight: 118.2 g/mol
Empirical Formula: C6H14O2

Appearance: Colorless, Liquid
Freezing Point: -50°C (-58.0°F)
Boiling Point: @ 760mm Hg 196°C (385°F)
Flash Point: Closed Cup 96°C (205°F)
Autoignition Temperature: 425°C (797°F)
Density @ 20°C: 0.924 kg/L, 7.71 lb/gal
Vapor Pressure: @ 20°C 0.05 mmHg
Evaporation Rate: (nBuAc = 1) 0.007
Solubility in Water: @ 20°C Miscible
Surface Tension @ 20°C: 33.1 dynes/cm
Refractive Index @ 20°C: 1.426
Viscosity @ 20°C: 38.9 cP
Lower Explosive Limit: 1.0 v/v%
Upper Explosive Limit: 9.9 v/v%
Conductivity @ 20°C: 3x106 pS/m

Dielectric Constant @ 20°C: ≈7.7
Specific Heat @ 20°C: 2.20 kJ/kg/°C
Heat of Vaporization @ normal boiling point: 435 kJ/kg
Heat of Combustion @ 25°C: 29875 kJ/kg
Odor Threshold: 50 ppm
Molecular Weight 118.2 g/mol
Empirical Formula C6H14O2
Appearance Colorless
Liquid
Freezing Point -50°C (-58.0°F)
Boiling Point @ 760mm Hg 196°C (385°F)
Flash Point – Closed Cup 96°C (205°F)
Autoignition Temperature 425°C (797°F)

Density @ 20°C 0.924 kg/L
7.71 lb/gal
Vapor Pressure @ 20°C 0.05 mmHg
Evaporation Rate (nBuAc = 1) 0.007
Solubility in Water @ 20°C Miscible
Surface Tension @ 20°C 33.1 dynes/cm
Refractive Index @ 20°C 1.426
Viscosity @ 20°C 38.9 cP
Lower Explosive Limit 1.0 v/v%
Upper Explosive Limit 9.9 v/v%
Conductivity @ 20°C 3x106 pS/m
Dielectric Constant @ 20°C ≈7.7
Specific Heat @ 20°C 2.20 kJ/kg/°C

Heat of Vaporization @ normal boiling point 435 kJ/kg
Heat of Combustion @ 25°C 29875 kJ/kg
Odor Threshold 50 ppm
CAS NO:107-41-5
EINECS NO:203-489-0
Molecular Formula:C6H14O2
Molecular Weight:118.1742
InChI:InChI=1/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3
Density:0.96g/cm3
Melting Point:-40ºC
Boiling Point:197.5°C at 760 mmHg
Flash Point:93.9°C
Water Solubility:soluble
Vapour Pressure:0.0961mmHg at 25°C

Refractive Rate:n20/D1.427(lit.)
Storage Condition:2-8°C
Appearance:Clear colorless Slightly Viscous Liquid
Odor:Ammonia-like
PH Value:6-8(25ºC,1MinH2O)
Explosive Limit:1-9.9%(V)
Sensitivity:Hygroscopic
Stability: Incompatible with strong oxidizing agents, strong acids,strong reducing agents.
Physical description: Colorless liquid with a mild, sweetish odor.
Boiling point: 388°F
Molecular weight: 118.2
Freezing point/melting point: -58°F (sets to glass)
Vapor pressure: 0.05 mmHg
Flash point: 209°F
Specific gravity: 0.923

Lower explosive limit (LEL): 1.3% (calc)
Upper explosive limit (UEL): 8.1% (calc)
NFPA health rating: 2
NFPA fire rating: 1
NFPA reactivity rating: 0
Appearance: colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.92400 @ 25.00 °C.
Melting Point: -40.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density: 4.1 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 0.004 (est)
Soluble in: alcohol
water, 3.256e+004 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)



FIRST AID MEASURES of HEXASOL HEXYLENE GLYCOL:
-Description of first-aid measures:
*General advice
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of HEXASOL HEXYLENE GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of HEXASOL HEXYLENE GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of HEXASOL HEXYLENE GLYCOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 240 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of HEXASOL HEXYLENE GLYCOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store under inert gas.
Hygroscopic.



STABILITY and REACTIVITY of HEXASOL HEXYLENE GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

HEXYL LAURATE, N° CAS : 34316-64-8, Nom INCI : HEXYL LAURATE. Nom chimique : Hexyl laurate. N° EINECS/ELINCS : 251-932-1. Emollient : Adoucit et assouplit la peau, Agent d'entretien de la peau : Maintient la peau en bon état

A high boiling point, slow evaporating solvent with excellent solvency characteristics.
Hexyl CELLOSOLVE Solvent has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, Hexyl CELLOSOLVE Solvent provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.

CAS: 112-25-4
MF: C8H18O2
MW: 146.23
EINECS: 203-951-1

The linear hexyl portion of this provides excellent oil solubility characteristics that make Hexyl CELLOSOLVE Solvent useful in both consumer and industrial cleaner applications.
Hexyl CELLOSOLVE Solvent plays an important role in specialty printing inks.
Because of Hexyl CELLOSOLVE Solvent's limited water solubility and slow evaporation, it can be used in formulations for the silk screen process to prevent premature setting of the ink.
Hexyl CELLOSOLVE Solvent is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
Hexyl CELLOSOLVE Solvent has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.

As a result, Hexyl CELLOSOLVE Solvent provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
Hexyl CELLOSOLVE Solvent used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.
Possesses high boiling point.
Exhibits very good solvency, superior oil solubility, and slow evaporation rate.
Hexyl CELLOSOLVE Solvent is a glycol ether that has a chemical formula of C8H18O2.

Hexyl CELLOSOLVE Solvent Chemical Properties
Melting point: -45.1℃
Boiling point: 98-99°C 0,15mm
Density: 0.888 g/mL at 20 °C(lit.)
Vapor pressure: 10Pa at 20℃
Refractive index: n20/D 1.431
Fp: 98-99°C/0.15mm
Storage temp.: -15°C
pka: 14.44±0.10(Predicted)
Form: clear liquid
Color: Colorless to Light yellow
Water Solubility: Soluble in alcohol and ether, water (9.46 g/L ).
BRN: 1734691
LogP: 1.97 at 25℃
CAS DataBase Reference: 112-25-4(CAS DataBase Reference)
EPA Substance Registry System: Hexyl CELLOSOLVE Solvent (112-25-4)

Uses
Hexyl CELLOSOLVE Solvent is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
Hexyl CELLOSOLVE Solvent is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
Hexyl CELLOSOLVE Solvent is used as high-boiling solvent.
Hexyl CELLOSOLVE Solvent also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
Hexyl CELLOSOLVE Solvent serves as a coalescing agent in cleaners and latex paints.

Hexyl CELLOSOLVE Solvent is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.
Hexyl CELLOSOLVE Solvent can be used as solvent in specialty printing inks.
Hexyl CELLOSOLVE Solvent can be used as coalescent for water-borne.
Hexyl CELLOSOLVE Solvent can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
Hexyl CELLOSOLVE Solvent can be used as primary solvent in solvent-based silk screen printing inks.

Hazards
According to the European Chemicals Agency, Hexyl CELLOSOLVE Solvent is classified as harmful when in contact with skin and when swallowed.
Hexyl CELLOSOLVE Solvent can also cause skin burns and serious eye damage.
Hexyl CELLOSOLVE Solvent was also known to cause kidney injury and depression.
Hexyl CELLOSOLVE Solvent is also a severe respiratory tract irritant.
Hexyl CELLOSOLVE Solvent may also have blood effects.
Hexyl CELLOSOLVE Solvent may enter the body through ingestion, aerosol inhalation, and through the skin.
Hexyl CELLOSOLVE Solvent may form explosive peroxides.
Hexyl CELLOSOLVE Solvent can react violently with strong oxidants.
Hexyl CELLOSOLVE Solvent is classified as a green circle product EPA Safer Choice meaning it is of low concern.

Synonyms
2-(Hexyloxy)ethanol
112-25-4
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
Ethylene glycol n-hexyl ether
2-Hexyloxy-1-ethanol
Ethanol, 2-hexyloxy-
Ethylene glycol-n-monohexyl ether
HSDB 5569
2-n-(Hexyloxy)ethanol
EINECS 203-951-1
BRN 1734691
UNII-7P0O8282NR
DTXSID1026908
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
EC 203-951-1
31726-34-8
4-01-00-02383 (Beilstein Handbook Reference)
DTXCID606908
2-(hexyloxy)ethan-1-ol
CAS-112-25-4
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
Etanol, 2-(hexiloxi)-
2-(1-Hexyloxy) ethanol
Ethylene glycol hexyl ether
SCHEMBL24741
CHEMBL3188016
(C2-H4-O)mult-C6-H14-O
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
LS-66802
FT-0631642
H0343
EN300-114321
F71224
500-077-5 (NLP #)
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)

Hexyl cellosolve solvent is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
Hexyl cellosolve solvent has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, Hexyl cellosolve solvent provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.

CAS: 112-25-4
MF: C8H18O2
MW: 146.23
EINECS: 203-951-1

Synonyms
2-(hexyloxy)-ethano;N-HEXYLMONOOXYETHYLENE;N-HEXYL CELLOSOLVE;C6E1;ETHYLENE GLYCOL MONOHEXYL ETHER;ETHYLENE GLYCOL MONO-N-HEXYL ETHER;ETHYLENE GLYCOL N-HEXYL ETHER;HEXYLGLYCOL
2-(Hexyloxy)ethanol;Ethanol, 2-(hexyloxy)-, 2-(HEXYLOXY)ETHANOL, 2-(Hexyloxy)ethanol C6E1 Hexylglycol, Hexyl Cellosolve, Ethylene Glycol Monohexyl Ether, 2-(Hexyloxy)ethanol, n-Hexylglycol, Ethylene glycol monohexyl ether, Ethylene glycol n-hexyl ether, 2-(Hexyloxy) ethanol, Ethylenglykolmonohexylether, 2-Hexyloxyethanol, 2-(Hexyloxy)ethanol, HEXYL GLYCOL, 2-Hexyloxyethanol, Hexoxyethylene glycol, 2-hexyloxyethanol, Ethylene glycol monohexyl ether, 2-hexyloxyethanol;112-25-4;Ethylene glycol monohexyl ether;2-Hexyloxyethanol;Ethanol, 2-(hexyloxy)-;2-HEXOXYETHANOL;Hexyl cellosolve;n-Hexyl cellosolve;Glycol monohexyl ether;Cellosolve, N-hexyl-;2-Hexyloxy-1-ethanol;Ethylene glycol n-hexyl ether;DTXSID1026908;7P0O8282NR;Ethylene glycol mono-n-hexyl ether;MFCD00045997;31726-34-8;DTXCID606908;Ethanol, 2-hexyloxy-;2-(hexyloxy)ethan-1-ol;CAS-112-25-4;Ethylene glycol-n-monohexyl ether;HSDB 5569;2-n-(Hexyloxy)ethanol;EINECS 203-951-1;BRN 1734691;Hexylglycol;UNII-7P0O8282NR;2-hexyloxy-ethanol;2-(n-Hexyloxy)ethanol;Ethylenglykolmonohexylether;2-(1-Hexyloxy) ethanol;EC 203-951-1;SCHEMBL24741;4-01-00-02383 (Beilstein Handbook Reference);C6E1;CHEMBL3188016;Tox21_202105;Tox21_300545;AKOS009156771;NCGC00248089-01;NCGC00248089-02;NCGC00254448-01;NCGC00259654-01;LS-13544;FT-0631642;H0343;NS00007590;EN300-114321;F71224;W-109065;Q27268660;Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)

A high boiling point, slow evaporating solvent with excellent solvency characteristics.
Hexyl cellosolve solvent has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, Hexyl cellosolve solvent provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of this provides excellent oil solubility characteristics that make Hexyl cellosolve solvent useful in both consumer and industrial cleaner applications.
Hexyl cellosolve solvent plays an important role in specialty printing inks.
Because of its limited water solubility and slow evaporation, Hexyl cellosolve solvent can be used in formulations for the silk screen process to prevent premature setting of the ink.
Hexyl cellosolve solventl or 2-(Hexyloxy)ethanol is a glycol ether that has a chemical formula of C8H18O2.

Hexyl cellosolve solvent Chemical Properties
Melting point: -45.1℃
Boiling point: 98-99°C 0,15mm
Density: 0.888 g/mL at 20 °C(lit.)
Vapor pressure: 10Pa at 20℃
Refractive index: n20/D 1.431
Fp: 98-99°C/0.15mm
Storage temp.: -15°C
pka: 14.44±0.10(Predicted)
Form: clear liquid
Color: Colorless to Light yellow
Water Solubility: Soluble in alcohol and ether, water (9.46 g/L ).
BRN: 1734691
LogP: 1.97 at 25℃
CAS DataBase Reference: 112-25-4(CAS DataBase Reference)
EPA Substance Registry System: Hexyl cellosolve solvent (112-25-4)

Uses
Hexyl cellosolve solvent is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
Hexyl cellosolve solvent is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
Hexyl cellosolve solvent is used as high-boiling solvent.
Hexyl cellosolve solvent also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
Hexyl cellosolve solvent serves as a coalescing agent in cleaners and latex paints.

Hazards
According to the European Chemicals Agency, Hexyl cellosolve solvent is classified as harmful when in contact with skin and when swallowed.
Hexyl cellosolve solvent can also cause skin burns and serious eye damage.
Hexyl cellosolve solvent was also known to cause kidney injury and depression.
Hexyl cellosolve solvent is also a severe respiratory tract irritant.
Hexyl cellosolve solvent may also have blood effects.
Hexyl cellosolve solvent may enter the body through ingestion, aerosol inhalation, and through the skin.
Hexyl cellosolve solvent may form explosive peroxides.
Hexyl cellosolve solvent can react violently with strong oxidants.
Hexyl cellosolve solvent is classified as a green circle product EPA Safer Choice meaning it is of low concern.

HEXYL GLYCOL = n-HEXYL GLYCOL = ETHYLENE GLYCOL MONOHEXYL ETHER = 2-(HEXYLOXY)ETHANOL


CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2


Hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
Hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
Hexyl glycol's miscibility with water, however, is limited.
Hexyl glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.


Since Hexyl glycol may react with the oxygen in the air to form peroxides.
Hexyl glycol, as known 2-Hexoxyethanol or 2-(Hexyloxy)ethanol, is a glycol ether that has a chemical formula of C8H18O2.
Hexyl glycol (Ethylene Glycol Monohexyl Ether), n°112-25-4 is measured by GC-FID.
A sample material must be taken using special equipment.


Hexyl glycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.
Hexyl glycol is a colorless liquid with a slight ether-like odor and bitter taste
Hexyl glycol's vapour is heavier than air.
Hexyl glycol is a colorless liquid with a slight ether odor and bitter taste.



USES and APPLICATIONS of HEXYL GLYCOL:
Hexyl glycol is used Industry, Scientific Research, Health, Environmental Protection, Agriculture
Usage of Hexyl glycol: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
Hexyl glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
Hexyl glycol is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.


For instance, it improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, it greatly improves film formation and levelling.
Hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.
Hexyl glycol can also be used in printing inks and cleaners.


Hexyl glycol is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
Other uses of Hexyl glycol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.
Hexyl glycol is used as a high-boiling solvent.


Hexyl glycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
Hexyl glycol is used as a coalescing agent in latex paints and cleaners.
Hexyl glycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
Hexyl glycol is used as high-boiling solvent.


Hexyl glycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
Hexyl glycol serves as a coalescing agent in cleaners and latex paints.
Hexyl glycol is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.
Hexyl glycol has excellent oil solubility, making it effective in household and industrial cleaning applications.


Hexyl glycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
Two solvents, Hexyl glycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
Hexyl glycol is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products


Hexyl glycol can be used as coalescent for water-borne.
Hexyl glycolcan be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
Hexyl glycol can be used as primary solvent in solvent-based silk screen printing inks.
Hexyl glycol is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.


Hexyl glycol can be used as a solvent in lacquers, paints, resins, dyes, oils and lubricants, as well as as a coupling and dispersant.
Hexyl glycol can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
Hexyl glycol is used as special solvent for coating and ink.
Hexyl glycol can be used as solvent in specialty printing inks.



ALTERNATIVE PARENTS of HEXYL GLYCOL:
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS of HEXYL GLYCOL:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of HEXYL GLYCOL:
Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -

Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Ų
Rotatable Bond Count: 7

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1

Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7
Exact Mass: 146.130679813
Monoisotopic Mass: 146.130679813
Topological Polar Surface Area: 29.5 Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of HEXYL GLYCOL:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of HEXYL GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of HEXYL GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of HEXYL GLYCOL:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of HEXYL GLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.



STABILITY and REACTIVITY of HEXYL GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available



SYNONYMS:
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(Hexyloxy)ethanol
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
2-Hexyloxy-1-ethanol
Ethylene glycol n-hexyl ether
2-n-(Hexyloxy)ethanol
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
DSSTox_CID_6908
DSSTox_RID_78248
DSSTox_GSID_26908
31726-34-8
Ethanol, 2-hexyloxy-
Ethylene glycol-n-monohexyl ether
HSDB 5569
Hexyl alcohol, ethoxylated
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
Poly(oxy-1,2-ethanediyl), .alpha.-hexyl-.omega.-hydroxy-
ZINC2041054
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
LS-13544
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)

hexyl laurate; Hexyl dodecanoate; Dodecanoic acid, hexyl ester; Hexyllaurat;Lauric acid hexyl ester; Einecs 251-932-1; Hexyl dodecanoat; Laurinsaeurehexylester cas no: 34316-64-8

HEXYL CINNAMAL; Noms français : ALDEHYDE HEXYLCINNAMIQUEOCTANAL, 2-(PHENYLMETHYLENE)-. Noms anglais :HEXYLCINNAMALDEHYDE; N° CAS : 101-86-0 - Hexylcinnamaldéhyde, Origine(s) : Synthétique. Autres langues : Hexil cinamal, Hexylzimt, Nom INCI : HEXYL CINNAMAL. Nom chimique : 2-Phenylmethyleneoctanal; alpha-Hexylcinnamaldehyde; 2-Benzylideneoctanal; alpha-n-hexyl-beta-phenylacrolein. N° EINECS/ELINCS : 202-983-3/639-566-4. Ses fonctions (INCI) : Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques. 2-(Phenylmethylene)octanal (2E)-?-hexylcinnamaldehyde (2E)-2-(phenylmethylidene)octanal (2E)-2-Benzylideneoctanal [ACD/IUPAC Name] (2E)-2-Benzylidèneoctanal [French] [ACD/IUPAC Name] (2E)-2-Benzylidenoctanal [German] [ACD/IUPAC Name] 101-86-0 [RN] 165184-98-5 [RN] 202-983-3 [EINECS] 2569 Cinnamaldehyde, α-hexyl- Cinnamaldehyde, α-hexyl- E9947QRR9O Hexyl cinnamal Hexyl cinnamaldehyde [Wiki] Hexyl cinnamic aldehyde MFCD00006989 [MDL number] Octanal, 2- (phenylmethylene)- Octanal, 2-(phenylmethylene)-, (2E)- [ACD/Index Name] α-hexyl cinnamaldehyde α-Hexylcinnamaldehyde α-Hexylcinnamaldehyde α-HEXYLCINNAMALDEHYDE, (2E)- α-Hexylcinnamic aldehyde α-Hexylcinnamic aldehyde (2E)-2-(phenylmethylene)octanal (2E)-2-hexyl-3-phenylprop-2-enal (2Z)-2-Benzylideneoctanal [ACD/IUPAC Name] (2Z)-2-Hexyl-3-phenyl-2-propenal (E)-2-benzylideneoctanal (E)-2-hexyl-3-phenyl-acrolein ??-hexylcinnamaldehyde ?-Hexylcinnamic aldehyde [101-86-0] 2-(Phenylmethylene)-Octanal 2-(Phenylmethylene)octanal, 9CI 2-(phenylmethylidene)octanal 2-[(E)-benzylidene]octanal 2-[1-Phenyl-meth-(E)-ylidene]-octanal 2502968 2-Hexenyl cynnamaldehyde 2-Hexyl-3-phenyl-2-propenal 2-hexyl-3-phenyl-acrolein 2-Hexyl-3-phenyl-propenal 2-Hexylcinnamaldehyde 3-Phenyl-2-propenal dimethyl acetal a-Hexylcinnamaldehyde, 8CI a-Hexylcinnamylaldehyde a-n-Hexyl-b-phenylacrolein BB_NC-0223 Benzoic acid, 4-(aminomethyl)- (9CI) Cinnamaldehyde, dimethyl acetal Cinnamaldehyde, α -hexyl- Cinnamic aldehyde dimethyl acetal FEMA 2569 H.C.A. Hexyl cinnamic aldehyde (VAN) Hexyl Cinnamic Aldehyde Natural -Hexyl-3-phenyl-propenal Hexylcinnamal Hexylcinnamaldehyde HEXYLCINNAMALDEHYDE with GC Jasmonal H. n-Hexyl cinnamaldehyde UNII:E9947QRR9O UNII-E9947QRR9O WLN: VHY6 & U1R α -hexylcinnamaldehyde α -hexylcinnamic aldehyde α -N-hexyl-α -hexylcinnamaldehyde α -N-hexyl-β -phenylacrolein α-hexylcinnamaldehyde α-Hexylcinnamyl aldehyde α-Hexyl-β-phenylacrolein α-N-Hexylcinnamaldehyde α-n-Hexylcinnamic aldehyde α-n-Hexyl-β-phenylacrolein α-n-Hexyl-β-phenylacrolein

2-Hexyl-1-decanol; 2425-77-6; 2-Hexyldecan-1-ol; 1-Decanol, 2-hexyl-; 2-Hexyldecyl Alcohol cas no: 2425-77-6

HEXYLDECANOL, N° CAS : 2425-77-6 - Hexyldécanol, Nom INCI : HEXYLDECANOL, Nom chimique : 2-Hexyldecan-1-ol, N° EINECS/ELINCS : 219-370-1, Compatible Bio (Référentiel COSMOS), Ses fonctions (INCI), Emollient : Adoucit et assouplit la peau, Agent d'entretien de la peau : Maintient la peau en bon état

HEXYLDECYL LAURATE, Nom INCI : HEXYLDECYL LAURATE, Nom chimique : 2-Hexyldecyl dodecanoate, Ses fonctions (INCI). Emollient : Adoucit et assouplit la peau. Agent d'entretien de la peau : Maintient la peau en bon état

Hexyldecyl stearate; Octadecanoic acid, 2-hexyldecyl ester; 17618-45-0; Eutanol G 16S; 2-Hexyldecyl stearate cas no: 17618-45-0

HEXYLENE GLYCOL; 2-Methyl-2,4-pentanediol; Diolane; Hexylene glycol; 2-Methylpentane-2,4-diol; 2-Metilpentano-2,4-diol; 2-Méthylpentane-2,4-diol; (+-)-2-Methyl-2,4-pentanediol; 1,1,3-Trimethyltrimethylenediol; 2,4-Dihydroxy-2-methylpentane; 4-Methyl-2,4-pentanediol; alpha,alpha,alpha'-Trimethyltrimethylene glycol; cas no: 107-41-5, 99113-75-4

Hexyldecyl stearate is a versatile emollient and solvent widely used in personal care products like skin creams, lotions, and sunscreens due to its ability to soften skin and reduce oiliness.
As a clear, low-viscosity ester, Hexyldecyl stearate enhances the spreadability and smoothness of formulations, making it ideal for cosmetics such as lipsticks, eye makeup, and skin care products.
In addition to its cosmetic applications, Hexyldecyl stearate is utilized as a lubricant and processing agent in industries like metalworking, textiles, and plastics, thanks to its excellent thermal stability and hydrophobic properties.

CAS Number: 22047-49-0
EC Number: 244-754-0
Molecular Formula: C26H52O2
Molecular Weight: 396.6899

Synonyms: 22047-49-0 [RN], 244-754-0 [EINECS], 2-ethylhexyl octadecanoate, 2-Ethylhexyl stearate [ACD/IUPAC Name], 2-Ethylhexylstearat [German] [ACD/IUPAC Name], ETHYLHEXYL STEARATE, Octadecanoic acid, 2-ethylhexyl ester [ACD/Index Name], Stéarate de 2-éthylhexyle [French] [ACD/IUPAC Name], [22047-49-0], 2-Ethylhexyl stearate, mixture of stearate and palmitate (7:3), 2-Ethylhexyl stearate, mixture of stearate and palmitate (7:3), Technical grade, 2-Ethylhexyloctadecanoate, 2-ETHYLHEXYLSTEARATE, AGN-PC-00L26C, CHEMBL3184927, DSSToxCID27178, DSSToxGSID47178, DSSToxRID82175, ethyl 4-hydroxycyclohexane-1-carboxylate, MFCD00072275 [MDL number], SCHEMBL153398, stearic acid, 2-ethylhexyl ester, Octadecanoic acid, octyl ester [ACD/Index Name], octyl octadecanoate, Octyl stearate [ACD/IUPAC Name], Octylstearat [German] [ACD/IUPAC Name], Stéarate d'octyle [French] [ACD/IUPAC Name], Stearic acid, octyl ester, 22047-49-0 [RN], 244-754-0 [EINECS], 2-ethylhexyl octadecanoate, 2-Ethylhexyl stearate [ACD/IUPAC Name], 2-Ethylhexylstearat [German] [ACD/IUPAC Name], ETHYLHEXYL STEARATE, Octadecanoic acid, 2-ethylhexyl ester [ACD/Index Name], Stéarate de 2-éthylhexyle [French] [ACD/IUPAC Name], [22047-49-0] [RN], 2-Ethylhexyl stearate, mixture of stearate and palmitate (7:3), 2-Ethylhexyloctadecanoate, 2-ETHYLHEXYLSTEARATE, AGN-PC-00L26C, CHEMBL3184927, DSSToxCID27178, DSSToxGSID47178, DSSToxRID82175, ethyl 4-hydroxycyclohexane-1-carboxylate, MFCD00072275 [MDL number], SCHEMBL153398, stearic acid, 2-ethylhexyl ester, 2-Ethylhexyl stearate, 22047-49-0, 2-Ethylhexyl octadecanoate, Ethylhexyl stearate, Cetiol 868, Octadecanoic acid, 2-ethylhexyl ester, EG3PA2K3K5, DTXSID9047178, Stearic acid, 2-ethylhexyl ester, C26H52O2, ethyl hexyl stearate, CRODAMOL OS, TEGOSOFT OS, ETHOX EHS, PELEMOL OS, EXCEPARL EH-S, UNII-EG3PA2K3K5, SCHEMBL153398, ?2-ETHYLHEXYL STEARATE, ESTOL 1545, CHEMBL3184927, DTXCID7027178, OPJWPPVYCOPDCM-UHFFFAOYSA-N, ETHYLHEXYL STEARATE [INCI], Tox21_302619, ETHYLHEXYL STEARATE [WHO-DD], MFCD00072275, AKOS015901877, NCGC00256861-01, CAS-22047-49-0, CS-0152204, FT-0756635, E78095, EC 244-754-0, W-110539, Q27277167, OCTADECANOIC ACID, 2-ETHYLHEXYL ESTER, (+/-)-, 2-Ethylhexyl stearate, mixture of stearate and palmitate (4:6)

Hexyldecyl stearate is commonly used as an emollient to deliver skin-softening properties and a smooth afterfeel.
Hexyldecyl stearate is a medium spreading emollient for all kind of cosmetic applications.

Hexyldecyl stearate or 2-Ethylhexyl stearate is an ester of stearic acid with octanol.
Hexyldecyl stearate is again one member of the groups called stearate esters which are obtained by reacting stearic acid with an alkyl group containing alcohol.

Stearate esters all have unique properties of oily nature, but low viscosity and lighter feel.
That’s why they are the choice of solvents in makeup related products.

Hexyldecyl stearate is obtained from various animal and plant source.
Hexyldecyl stearate comes as clear to slightly yellowish liquid.

Hexyldecyl stearate, also known as Ethylhexyl Stearate or 2-Ethylhexyl stearate, is a renewable palm derivative with a variety of uses in both personal care and cosmetics manufacturing.
Hexyldecyl stearate is a stearate ester with similar properties to Isopropyl Myristate.
As with all stearate personal care esters, the Hexyldecyl stearate manufacturing process entails a reaction between Hexyldecyl stearate and alcohols such as cetyl, butyl, isopropyl or myristyl alcohol.

Hexyldecyl stearate is a fatty acid derived from animal fat.
Hexyldecyl stearate acts as a lubricant that softens the skin and gives Hexyldecyl stearate a smooth appearance.

Hexyldecyl stearate is excellent liquid emollient and thickening agent for cosmetic formulations.
Hexyldecyl stearate provides a soft barrier to the skin to impart moisturization and a smooth feel.

Hexyldecyl stearate is a clear, almost colorless (or slightly yellowish) oily liquid (an ester to be precise) that's used as a medium spreading emollient.
Hexyldecyl stearate gives skin a nice and smooth after-feel and it's very good at reducing oiliness or greasiness coming from other heavier oils in the formula.

Hexyldecyl stearate is used an emollient derived from plant oil that prevents water loss
Hexyldecyl stearate is also known as 2-Ethylhexyl stearate.

Hexyldecyl stearate also known as 2-Ethylhexyl Octadecanoate or 2-Ethylhexyl stearate is a palm derivative which is renewable in nature and is extensively used in personal care industry.
The stearate esters are prepared by the reaction between Hexyldecyl stearate and alcohol such as isopropyl, ethylhexyl, myistyl alcohol, cetyl, butyl among others.

Hexyldecyl stearate can be obtained form from animal origin as well as vegetable fats.
Hexyldecyl stearate is prepared by the reaction between Hexyldecyl stearate and ethylhexyl alcohol.

Hexyldecyl stearate is a clear ester liquid which is free of suspended matter and is available in colourless liquid form.
Ethylhexyl alcohol possess unique property of low viscosity and oily nature owing to which when applied on skin or lips Hexyldecyl stearate forms an hydrophobic film.
Thereby, softens the skin and imparts smooth appearance.

With rising consumer concern towards personal health, demand for personal care serices and products are witnessing a substantial growth.
Thereby, boosting the market growth of Hexyldecyl stearate as Hexyldecyl stearate is commonly used ester in personal care products.

Hexyldecyl stearate is commonly used as an emollient which prevents the water loss.
Hence, is extensively used as emulsion, bath oils and as solvent in cosmetic products.

Hexyldecyl stearate is widely used in the manufacturing of formulations for skin make up, lipstick, eye liner and other skin care products.
Apart from personal care industry, Hexyldecyl stearate also widely used as an intermediate, lubricating agent and surface active agent.

Owing to these properties ethtylhexyl stearate is commonly used in the manufacturing of metal working fluids.
Also, Hexyldecyl stearate offers good thermal stability and hence finds application in aluminium rolling, also is used in manufacturing of ink additives and paints.
Hence, broad spectrum of application provides an opportunistic platform for the robust growth of Hexyldecyl stearate market over the period of time.

Hexyldecyl stearate is a special emollient ester in cosmetic formulations.
Hexyldecyl stearate is a softening, thickening agent, dispersant and solvent.

Hexyldecyl stearate is often used as a base for skin care agents.
Hexyldecyl stearate is suitable for use in lotions, sunscreens, hair care, lip care, eye care, antiperspirant and bath oils.
Hexyldecyl stearate is oil soluble and supplied as a whitish clear liquid.

Hexyldecyl stearate, also known as Ethylhexyl Stearate or 2-Ethylhexyl stearate, is a renewable palm derivative that has a variety of uses in both personal care and cosmetic manufacturing.
Hexyldecyl stearate is a stearate ester with similar properties to Isopropyl Myristat.

As with all stearate personal care esters, the Hexyldecyl stearate manufacturing process causes a reaction between Hexyldecyl stearate and alcohols such as cetyl, butyl, isopropyl or myristyl alcohol.
Hexyldecyl stearate acts as a lubricant that softens the skin and gives Hexyldecyl stearate a smooth appearance.

Hexyldecyl stearate or 2-Ethylhexyl stearate, is a date derivative that is renewable in nature and widely used in the personal care industry.
Stearate esters are prepared by the reaction between Hexyldecyl stearate and alcohol such as isopropyl, ethylhexyl, myistyl alcohol, cetyl, butyl, among others.

Hexyldecyl stearate can be obtained from vegetable oils as well as from animal origin.
Hexyldecyl stearate is prepared by the reaction between Hexyldecyl stearate and ethylhexyl alcohol.

Hexyldecyl stearate is a clear ester liquid with no suspended matter and available in colorless liquid form.
Ethylhexyl alcohol has a unique property of low viscosity and oily nature, as Hexyldecyl stearate forms a hydrophobic film when applied to the skin or lips.
Thus, Hexyldecyl stearate softens the skin and gives Hexyldecyl stearate a smooth appearance.

Hexyldecyl stearate is an excellent moisturizer with low comedogenicity and medium spreading properties.
Hexyldecyl stearate gives the skin a soft and smooth appearance while preventing water loss.
Hexyldecyl stearate is very suitable for use in sun screen formulations.

Hexyldecyl stearate is a renewable palm derivative with a variety of uses in both personal care and industrial applications.
Hexyldecyl stearate is used in cosmetic formulations as a solvent, carrying agent, wetting agent, emollient, and used mostly in the formulation of, eye/skin makeup, lipstick and skin care products.
Hexyldecyl stearate also widely used in metal working fluids, textile auxiliaries and lube & grease.

Hexyldecyl stearate is a chemical compound that belongs to the family of esters.
Hexyldecyl stearate is commonly used in various industries, including cosmetics, pharmaceuticals, and plastics.
This paper aims to provide a comprehensive review of Hexyldecyl stearate, including Hexyldecyl stearate method of synthesis or extraction, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges.

Hexyldecyl stearate is a low odor product with resistance to extraction by water, oils and solvents.
Hexyldecyl stearate is the least effective costabilizer on Hexyldecyl stearate range due to Hexyldecyl stearate lower oxirane value but is good at reducing viscosity in plastisols and remains liquid down to -20°C.

Hexyldecyl stearate is used in cosmetics to provide a barrier between skin and the elements, and to soften and smooth the skin.
Hexyldecyl stearate used in cosmetics as a thickening agent and emollient.

Hexyldecyl stearate used as plasticizer for natural rubber and synthetic rubber.
Hexyldecyl stearate used as release agent.

Hexyldecyl stearate used as lubricating agent for process aluminium foil; creates plasticity.
Hexyldecyl stearate used in the pharmaceutical industry and in plastics; oil agent of textile; additive for leather.

Hexyldecyl stearate is a light ester with low viscosity (7-10,5 cSt) and emollient properties.
Hexyldecyl stearate improves the spreadability of preparations, Hexyldecyl stearate easily absorbed and leaves a non-greasy, non-occlusive protective film on the skin, which feels silky and smooth.
Hexyldecyl stearate is ideal on makeup formulations such as lipsticks and mascaras.

Hexyldecyl stearate is an ester of stearic acid and 2-ethylhexanol.
Hexyldecyl stearate is a clear, colorless liquid with a faint odor and a low viscosity.

The chemical formula of Hexyldecyl stearate is C26H52O2, and Hexyldecyl stearate has a molecular weight of 368.64 g/mol.
Hexyldecyl stearate is commonly used in the cosmetic industry as an emollient and a solvent.

As an emollient, Hexyldecyl stearate has a softening and smoothing effect on the skin and hair, making them feel less greasy and more comfortable.
As a solvent, Hexyldecyl stearate can dissolve other ingredients and help them spread more evenly on the skin or hair.
Hexyldecyl stearate is considered safe for use in cosmetics, and Hexyldecyl stearate low toxicity makes Hexyldecyl stearate an attractive ingredient for a variety of personal care products.

Hexyldecyl stearate is also known as 2-Ethylhexyl stearate, Hexyldecyl stearate can be used as a lubricant in all kinds of cosmetic products.
Hexyldecyl stearate is an IPM alternative.
Hexyldecyl stearate has a medium-low lubrication feel.

Hexyldecyl stearate can be used in products where oiliness is not desired.
Hexyldecyl stearate will also reduce the oiliness of other oils.

Hexyldecyl stearate is a cream-type cleansing cosmetic compound containing large amount of oil phase and Hexyldecyl stearate manufacturing method.
In cosmetics and personal care products, stearate esters are used most frequently in the formulation of eye makeup, skin makeup, lipstick and skin care products.

Hexyldecyl stearate is used in personal care applications and and in can lubes.
Hexyldecyl stearate is a palm dervied product made from Stearic Acid and 2-Ethylhexanol.

Hexyldecyl stearate can be considered a protector of the skin.
Hexyldecyl stearate is an emollient derived from plant oil.

The lipide prevents water loss and therefore helps the skin to efficiently store moisture.
Hexyldecyl stearate is acts as a good moisturizer and emollient for skin creams, lotions and sunscreen.

Hexyldecyl stearate is a cationic polymerization that is used in the production of polyvinyl chloride.
Hexyldecyl stearate has been shown to be an effective additive for hydrophobic effects, and Hexyldecyl stearate has very high values for surface methodology.

Hexyldecyl stearate is also clinically proven to have skin cell penetration properties and can be used as a carrier agent for other ingredients.
The fatty acid portion of this molecule provides hydroxyl groups, which may help with the function of dimethyl fumarate.
Hexyldecyl stearate also contains a potassium hexafluorophosphate group in Hexyldecyl stearate structure, which can be used as an emulsifier or dispersant.

Hexyldecyl stearate is mainly a skin conditioning ingredient and Hexyldecyl stearate acts primarily as lubricant on the skin's surface, which gives the skin a soft and smooth appearance.
In our products, Hexyldecyl stearate is used as hair conditioner.
Hexyldecyl stearate helps to increase the softness and smoothness of hair, reduce tangles and surface roughness.

Use and Benefits of Hexyldecyl Stearate:
Hexyldecyl stearate is also linked to skin’s natural fatty acid content, so Hexyldecyl stearate is ideal for skin preparation.
Moreover, Hexyldecyl stearate imparts the right amount of viscosity to Hexyldecyl stearate, Hexyldecyl stearate acts as a thickening agent as well.

Hexyldecyl stearate also forms a film over the skin, a hydrophobic barrier which does not let the moisture pass through and escape from the skin.
And without any greasy feel, Hexyldecyl stearate moisturizes the skin.

Hexyldecyl stearate also nourishes the skin and provides a protective barrier; moist skin is healthy enough to fight any external inflammation.
After regular application, resultant skin may become softer and smoother.
Hexyldecyl stearate is most frequently used in skincare products, lipstick, skin makeup, and eye makeup.

Hexyldecyl stearate is a surfactant with a wide variety of applications and can be found, for example, as a solvent in lubricants and lubricant additives, surface treatment agents.
The following consumer products may contain Hexyldecyl stearate: fabrics, textiles and leather products, detergents, dishwashing liquids, lubricants, oils (excluding food oils) and others.

Hexyldecyl stearate is often used as an emollient to prevent water loss.
For this reason, Hexyldecyl stearate is widely used as a solvent in emulsions, bath oils and cosmetic products.

Hexyldecyl stearate is widely used in the production of formulations for skin make-up, lipstick, eyeliner and other skin care products.
Besides the personal care industry, Hexyldecyl stearate is also used as an intermediate, lubricant and surfactant oris widely used.

Because of these properties, Hexyldecyl stearate is widely used in the production of metalworking fluids.
Hexyldecyl stearate also offers good thermal stability and therefore finds application in aluminum rolling, Hexyldecyl stearate is also used in the manufacture of ink additives and paints.
Therefore, Hexyldecyl stearate wide range of applications provides an opportunistic platform for the Hexyldecyl stearate market to grow strongly over time.

However, with the increasing demand for organic and natural personal care products, various natural-based ingredients are used in the production of personal care products.
Thus, Hexyldecyl stearate limits the market growth of Hexyldecyl stearate.

Moreover, Hexyldecyl stearate is derived from animal fat, which is hindering the growth of the Hexyldecyl stearate market with the increasing adoption of vegan-based products.
Hexyldecyl stearate also causes mild eye irritation and produces a mild odor, which may affect the adoption of ethyl stearate-based products among consumers.

Usage Areas:
Hexyldecyl stearate is used in cosmetic Softener, Dispersant, Solvent and Thickener.
Hexyldecyl stearate is used in metalworking lubricant.

Hexyldecyl stearate is branched chain softener ester specially developed for personal care and pharmaceutical applications.
Hexyldecyl stearate is non-occlusive with good spreading properties.

Hexyldecyl stearate is excellent super lubricant in detergent systems and soaps.
Hexyldecyl stearate is increases hair shine.
Hexyldecyl stearate is used in bath oils, skin cleansers, shampoos and conditioners.

Cosmetic use:
Hexyldecyl stearate is used in oil-based with low viscosity, high penetration and spreading effect.

Uses at industrial sites:
Hexyldecyl stearate is used in the following products: washing & cleaning products, metal surface treatment products, polymers, textile treatment products and dyes and pH regulators and water treatment products.
Hexyldecyl stearate is used for the manufacture of: textile, leather or fur.
Release to the environment of Hexyldecyl stearate can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid, as processing aid and as an intermediate step in further manufacturing of another substance (use of intermediates).

Industry Uses:
Lubricants and lubricant additives
Plating agents and surface treating agents
Solvents (which become part of product formulation or mixture)
Surface active agents
Emulsifier
Hydraulic fluids
Intermediate
Lubricants and lubricant additives
Lubricating agent
Other
Solubility enhancer
Surface modifier
Surfactant (surface active agent)

Consumer Uses:
Hexyldecyl stearate is used in the following products: washing & cleaning products, adhesives and sealants, lubricants and greases, polymers, textile treatment products and dyes, plant protection products, polishes and waxes and fertilisers.
Release to the environment of Hexyldecyl stearate can occur from industrial use: in the production of articles and in processing aids at industrial sites.
Other release to the environment of Hexyldecyl stearate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Other consumer Uses:
Fabric, textile, and leather products not covered elsewhere
Laundry and dishwashing products
Lubricants and greases
Non-TSCA use
Personal care products
Emulsifier
Hydraulic fluids
Intermediate
Lubricants and lubricant additives
Lubricating agent
Other
Solubility enhancer
Surfactant (surface active agent)

Applications of Hexyldecyl Stearate:
Hexyldecyl stearate acts as a good moisturizer and emollient in personal care formulations like skin creams, lotions and sunscreens.
Hexyldecyl stearate is also finds use in color cosmetics like eyebrow pencil, concealer, lipstick etc.
Hexyldecyl stearate is used as an oil component for bath oils, bath emulsions, and as a solvent for active substances in cosmetics.

Hexyldecyl stearate is a variety of resin processing of the lubricant, non-toxic, with water resistance and good thermal stability.
Mainly used for PVC transparent soft and hard extrusion, injection molding, calendering products, the amount of 0.5-1 copies.

Hexyldecyl stearate of the modified vinyl chloride - vinyl acetate copolymer, polystyrene, nitrile rubber and other processing performance is also very effective.
Hexyldecyl stearate can also be used as a lubricant for fabrics, waterproofing agents, lubricants additives, cosmetics base material and so on.

Hexyldecyl stearate is a specialty emollient ester.
Hexyldecyl stearate is a superior emollient, thickening agent, dispersant, and solvent.

Hexyldecyl stearate properties allow use as a cleaner or diluent for lipophilic systems; cosmetic emollient and dispersant; plastic additive as external lubricant; industrial lubricant or separator; substitution of mineral, vegetable and selected silicone oils; and pigment binding and dispersing coagent.

Categories: Thickeners / Emulsifiers, Texture Enhancer, Softeners
Hexyldecyl stearate is often used as an emollient for Hexyldecyl stearate skin softening properties and smooth feel.

Hexyldecyl stearate is often used as the base for skin conditioning agents.
Suitable for use in lotions, sunscreens, hair care, lip care, eye care, antiperspirants, and bath oils.

Hexyldecyl stearates serve as intermediates, surface active agents and lubricants/lubricant additives.

Hexyldecyl stearate is functions include the following.
CASE: Paint and Ink Additive
Lube and Grease: Oil Base Fluid
Metal Working Fluids: Lubricant with Excellent Adhesion to Metals and Good Thermal Stability. Also Used in Aluminum Rolling
Plastics: Lubricant
Rubber: Processing Agent
Textiles: Oiling Agent
Personal Care: Thickening Agent, Skin Conditioning Agent and Emollient in Skin Care Products
Cosmetics: Used as a Base, a Thickening Agent, a Pigment Wetting Agent, a Dispersant, a Solvent and an Emollient in Skin and Eye Make-Up and in Lipstick.
Personal care products/cosmetics using Hexyldecyl stearate: Lipstick, eye makeup, skin care and makeup products, moisturizers, anti-wrinkle creams and lotions, anti-aging products, hair conditioners and styling products, baby lotions and eye shadow

Industry Based Hexyldecyl stearate Applications:
Personal care
Textile
Chemicals

Applications of Hexyldecyl stearate based on functionality:
Lubrication
Processing
Darkening
Distributor

Other Applications:
After sun
Baby Care and Cleaning
Body care
Color Care
Facial Facial
Personal Cleaner
Care Wipes
Self Tanning
Sun protection
Bath, Shower & Soaps
Eye Colour
Face / Neck Skin Care
Face Colour
Facial Cleansers
Hair Conditioners - Rinse off
Lip Colour
Shampoos
Sun Protection
Tanning

Method of Synthesis or Extraction of Hexyldecyl Stearate:
Hexyldecyl stearate can be synthesized by the esterification of stearic acid with 2-ethylhexanol.
The reaction is catalyzed by an acid catalyst, such as sulfuric acid or p-toluenesulfonic acid.

The efficiency and yield of this method depend on the reaction conditions, such as temperature, pressure, and reaction time.
The yield of this method is typically high, ranging from 80% to 95%.
However, this method may have environmental and safety considerations, such as the use of hazardous chemicals and the generation of waste.

Chemical Structure and Biological Activity of Hexyldecyl Stearate:
Hexyldecyl stearate has a chemical formula of C24H48O2 and a molecular weight of 368.64 g/mol.
Hexyldecyl stearate is a colorless to pale yellow liquid with a faint odor.

Hexyldecyl stearate has been shown to have various biological activities, including anti-inflammatory, antioxidant, and antimicrobial activities.
Hexyldecyl stearate acts by inhibiting the production of pro-inflammatory cytokines, scavenging free radicals, and disrupting the cell membrane of microorganisms.

Biological Effects of Hexyldecyl Stearate:
Hexyldecyl stearate has been shown to have potential therapeutic effects on various diseases, such as acne, psoriasis, and atopic dermatitis.
Hexyldecyl stearate can improve skin hydration, reduce skin irritation, and enhance the penetration of active ingredients.

However, Hexyldecyl stearate may also have potential toxic effects, such as skin sensitization, eye irritation, and reproductive toxicity.
The toxicity of Hexyldecyl stearate depends on the dose, exposure route, and duration.

General Manufacturing Information of Hexyldecyl Stearate:

Industry Processing Sectors:
All Other Chemical Product and Preparation Manufacturing
Computer and Electronic Product Manufacturing
Electrical Equipment, Appliance, and Component Manufacturing
Fabricated Metal Product Manufacturing
Machinery Manufacturing
Miscellaneous Manufacturing
Oil and Gas Drilling, Extraction, and Support activities
Petroleum Lubricating Oil and Grease Manufacturing
Printing Ink Manufacturing
Printing and Related Support Activities
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Textiles, apparel, and leather manufacturing
Transportation Equipment Manufacturing

Functions of Hexyldecyl Stearate:
According to Chemiplast, a Belgian researcher, Hexyldecyl stearate is used as an oil component for emulsions, bath oils, and as a solvent for active substances in cosmetics.
Stearate esters are used most frequently in the formulation of eye makeup, skin makeup, lipstick and skin care products.

Properties of Hexyldecyl Stearate:
Hexyldecyl stearate is a clear liquid ester that is free of suspended matter, although Hexyldecyl stearate may also be a waxy solid.
Colorless in its liquid form, Hexyldecyl stearate produces a faint odor.

Hexyldecyl stearate is soluble in many organic solvents, although Hexyldecyl stearate is insoluble in water and Hexyldecyl stearate can also dissolve other substances.
When applied to the skin, Hexyldecyl stearate will leave a thin coating upon drying.
Hexyldecyl stearate also reduces the thickness of lipsticks.

Handling and Storage of Hexyldecyl Stearate:

Handling:
Avoid prolonged or repeated contact with skin.
Use appropriate personal protective equipment.
Keep away from sources of ignition.

Storage:
Store in a cool, dry, well-ventilated area away from heat and open flames.
Keep containers tightly closed when not in use.
Ensure that storage facilities are equipped to handle spills and leaks.

Hexyldecyl stearate at normal temperatures and provide adequate ventilation.
Keep Hexyldecyl stearate from contacting oxidizing agents and observe all local regulations regarding safe product disposal.

Reactivity of Hexyldecyl Stearate:

Chemical Stability:
Hexyldecyl Stearate is generally stable under normal conditions.

Conditions to Avoid:
Avoid exposure to high temperatures, flames, and oxidizing conditions.

Incompatible Materials:
Strong oxidizing agents and acids may react with Hexyldecyl Stearate.

Hazardous Decomposition Products:
Decomposition may produce carbon oxides and other potentially harmful substances.

Safety of Hexyldecyl Stearate:
The Hexyldecyl stearate safety sheet indicates this chemical product is not hazardous.
However, Hexyldecyl stearate can cause irritation to the eyes or when ingested, although Hexyldecyl stearate is unlikely to cause skin irritation.
Hexyldecyl stearate will remain stable under typical handling and working conditions.

First Aid Measures of Hexyldecyl Stearate:

Inhalation:
Move the person to fresh air.
If breathing is difficult, administer oxygen and seek medical attention.

Skin Contact:
Wash the affected area with soap and water.
Remove contaminated clothing and seek medical attention if irritation persists.

Eye Contact:
Rinse eyes with plenty of water for at least 15 minutes, holding the eyelids open.
Seek medical attention if irritation persists.

Ingestion:
Do not induce vomiting.
Rinse mouth and drink plenty of water.
Seek medical attention immediately.

Fire Fighting Measures of Hexyldecyl Stearate:

Fire Extinguishing Media:
Use foam, dry chemical, carbon dioxide (CO2), or water spray to extinguish fires.

Fire Fighting Procedures:
Wear self-contained breathing apparatus (SCBA) and protective clothing.
Cool containers with water spray to prevent rupture.

Hazards:
Combustion may produce fumes of carbon oxides and other hazardous compounds.
Avoid inhalation of smoke.

Accidental Release Measures of Hexyldecyl Stearate:

Personal Precautions:
Wear appropriate protective equipment, including gloves and goggles.
Ensure adequate ventilation.

Containment:
Prevent spillage from entering drains or waterways.
Contain the spill with absorbent materials such as sand or earth.

Cleanup:
Collect and dispose of the spilled material in accordance with local regulations.
Clean the area with detergent and water.

Exposure Control/Personal Protection of Hexyldecyl Stearate:

Occupational Exposure Limits:
No specific exposure limits are generally established for Hexyldecyl Stearate, but ensure exposure is minimized.

Engineering Controls:
Use in well-ventilated areas.
Employ local exhaust ventilation if necessary.

Personal Protective Equipment (PPE):

Respiratory Protection:
Use a respirator with a filter if exposure limits are exceeded or if there is insufficient ventilation.

Hand Protection:
Wear protective gloves to prevent skin contact.

Eye Protection:
Use safety goggles or face shields to protect against splashes.

Skin Protection:
Wear protective clothing as necessary to prevent skin exposure.

Identifiers of Hexyldecyl Stearate:
CAS No.: 22047-49-0
Chemical Name: 2-ETHYLHEXYL STEARATE
CBNumber: CB8120607
Molecular Formula: C26H52O2
Molecular Weight: 396.69
MDL Number: MFCD00072275

Properties of Hexyldecyl Stearate:
Appearance @ 20°C: Clear to light yellow liquid
Acid value (MGKOH/G): 1 Maximum
Saponification value: 142-156
Iodine value (WIJS): 1 Maximum
Hydroxyl value (MGKOH/G): 3 Maximum
Refractive index @ 25°C: 1.445-1.448
Specific gravity @25°C: 0.850-0.860

Density: 0.86g/cm3
Boiling Point: 438.7ºC at 760mmHg
Molecular Formula: C26H52O2
Molecular Weight: 396.69000
Flash Point: 225.6ºC
Exact Mass: 396.39700
PSA: 26.30000
LogP: 9.15160
Vapour Pressure: 6.79E-08mmHg at 25°C
Index of Refraction: 1.451

Boiling point: 420.33°C (rough estimate)
Density: 0.8789 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.4563 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Hexanes (Slightly)
form: Oil
color: Colourless
Specific Gravity: 0.826
InChI: InChI=1S/C26H52O2/c1-4-7-9-10-11-12-13-14-15-16-17-18-19-20-21-23-26(27)28-24-25(6-3)22-8-5-2/h25H,4-24H2,1-3H3
InChIKey: OPJWPPVYCOPDCM-UHFFFAOYSA-N
SMILES: C(OCC(CC)CCCC)(=O)CCCCCCCCCCCCCCCCC
LogP: 11.994 (est)

Molecular Weight: 396.7 g/mol
XLogP3-AA: 11.7
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 23
Exact Mass: 396.396730897 g/mol
Monoisotopic Mass: 396.396730897 g/mol
Topological Polar Surface Area: 26.3Ų
Heavy Atom Count: 28
Complexity: 314
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Related Products of Hexyldecyl Stearate:
(2'S)-Nicotine 1-Oxide-d4
rac-Nicotine 1-Oxide-d4
1,7-Dimethyl-1H-imidazo[4,5-g]quinoxalin-2-amine
Disulfoton Sulfone
Disulfoton

Names of Hexyldecyl Stearate:

IUPAC names:
2-ethylhexyl octadecanoate
2-Ethylhexyl Stearate
2-Ethylhexyl stearate
2-ethylhexyl stearate
2-ethylhexyl stearate
LINCOL 60 LINCOL OS
octadecanoic acid, 2-ethylhexyl ester
Octadecanoic acid, 2-ethylhexyl ester + Hexadecanoic acid, 2-ethylhexyl ester
octyl octadecanoate
Viscostatic E20

Hexylene Glycol largely acts as a solvent, humectant, and viscosity agent.
Hexylene Glycol′s a category of glycol often utilized as a solvent, humectant, and an agent to control viscosity.
Hexylene Glycol is a clear, colorless liquid chemical compound with the molecular formula C6H14O2.


CAS Number: 107-41-5
EC Number: 203-489-0
MDL number: MFCD00004547
Chem/IUPAC Name: 2-Methylpentane-2,4-diol
Molecular Formula: C6H14O2 or (CH3)2COHCH2CHOHCH3



2-Methyl-2,4-Pentanediol, 2-Methylpentane-2,4-Diol, Diolane, Hexylene Glycol (2-Methyl-2,4-Pentanediol, Isol, Pinakon, MPD, Hexane-1,2-Diol, (4S)-2-Methylpentane-2,4-Diol, (4R)-2-Methylpentane-2,4-Diol, Hexasol, 2,4-dihydroxy-2-methylpentane, 2-methyl-2,4-pentanediol, 4-methyl-2,4-pentanediol, 2-methylpentane-2,4-diol, 2,4-Dihydroxy-2-methylpentane, 2-Methyl-2,4-pentanediol, 4-Methyl-2,4-pentanediol, 2-Methylpentane-2,4-diol, 2,4-Pentanediol, 2-methyl-, α,α,α'-Trimethyltrimethylene glycol, Diolane, Isol, 1,1,3-Trimethyltrimethylenediol, 2-Methyl-2,4-pentandiol, 2-Methyl-2,4-pentanediol, 2,4-Dihydroxy-2-methylpentane, 4-Methyl-2,4-pentanediol, 2-Methyl pentane-2,4-diol, 2-Methylpentan-2,4-diol, Pinakon, 4-Methyl-2,4-pentanediole, (.+/-.)-2-Methyl-2,4-pentanediol, NSC 8098, Isophthalic acid, 2-Methyl-2,4-pentanediol1,1,3-Trimethyltrimethylenediol2,4-Dihydroxy-2-methylpentane2-Methyl pentane-2,4-diol4-Methyl-2,4-pentanediolTrimethyltrimethylene glycolDiolaneIsolPinakonHexG, (2,4-dihydroxy-2-methylpentane, 2,4-pentanediol, 2-methyl-, 2-methylpentane-2,4-diol, 4-methyl-2,4-pentanediol, alpha,alpha,alpha’-trimethyltrimethylene glycol, diolane, hexylene glycol, isol, pinakon, 2,4-Pentanediol,2-methyl-, 2-Methyl-2,4-pentanediol, 2,4-Dihydroxy-2-methylpentane, Diolane, Hexylene glycol, Isol, α,α,α′-Trimethyltrimethylene glycol, 1,1,3-Trimethyltrimethylenediol, MPD, (±)-2-Methyl-2,4-pentanediol, NSC 8098, Hexasol, Isohexanediol, 99113-75-4, 2-furanmethanol, 2-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, Hexylene glycol, 2-METHYL-2,4-PENTANEDIOL, 107-41-5, 2-Methylpentane-2,4-diol, Diolane, Pinakon, 2,4-Pentanediol, 2-methyl-, 2,4-Dihydroxy-2-methylpentane, Isol, 4-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, Caswell No. 574, 2-Methyl pentane-2,4-diol, 2-Methyl-2,4-pentandiol, hexyleneglycol, HSDB 1126, UNII-KEH0A3F75J, (+-)-2-Methyl-2,4-pentanediol, NSC 8098, NSC-8098, EINECS 203-489-0, KEH0A3F75J, alpha,alpha,alpha'-Trimethyltrimethylene glycol, EPA Pesticide Chemical Code 068601, BRN 1098298, 1,3-dimethyl-3-hydroxybutanol, CCRIS 9439, DTXSID5021885, CHEBI:62995, AI3-00919, Hexylene glycol [NF], 1,3,3-trimethyl-1,3-propanediol, TRACID RUBINE 5BL, DTXCID101885, EC 203-489-0, 1,1,3-trimethyl-1,3-propanediol, 4-01-00-02565 (Beilstein Handbook Reference), Hexylene glycol (NF), 7-MethylAtracuriumDimesylate(MixtureofDiastereomers), MPD, CAS-107-41-5, 2-Methylpentan-2,4-diol, 2-Methyl-pentane-2,4-diol, 64229-01-2, MFCD00004547, Hexylene glycol, 99%, R-(-)-2-METHYL-2,4-PENTANEDIOL, 2methyl-2,4-pentanediol, Hexylene glycol, >=99%, Hexylene glycol, 99.5%, SCHEMBL19379, 1,3-Trimethyltrimethylenediol, CHEMBL2104293, NSC8098, (?)-2-Methyl-2,4-pentanediol, SVTBMSDMJJWYQN-UHFFFAOYSA-N, HMS3264E19, HY-B0903, Hexylene glycol, analytical standard, Tox21_201975, Tox21_302818, s3588, AKOS015901459, CCG-213719, WLN: QY1 & 1XQ1 & 1, NCGC00249143-01, NCGC00256494-01, NCGC00259524-01, AC-13749, AS-58339, Hexylene glycol, BioXtra, >=99% (GC), (+/-)-2-Methyl-2,4-pentanediol, MPD, FT-0605050, FT-0605756, FT-0613069, Hexylene glycol, puriss., >=99.0% (GC), M0384, (S)-(-)-2-METHYL-2,4-PENTANEDIOL, .alpha.,.alpha.'-Trimethyltrimethylene glycol, Hexylene glycol, BioUltra, >=99.0% (GC), D04439, EN300-170052, AB01563179_01, J-640306, J-660006, Q2792203, W-108748, Z1255485267, Hexylene glycol, United States Pharmacopeia (USP) Reference Standard, Diolane, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, MPD, MVD, FP17780, NSC 66498, Einecs 227-150-, 3-Methylpentanediol-2,4, 2-METHYLPENTANE-2,4-DIOL, 3-METHYL-2,4-PENTANEDIOL, 3-methyl-pentane-2,4-diol, 2,4-Pentanediol, 3-methyl-, HGL, Diolane, Isol, Pinakon, 1,1,3-Trimethyl-Triethylenediol, Diacetone Glycol, Methylamilene Glycol, 2,4-Dihydroxy-2- Methyl-Penthane, 2-Methyl-Penthane-2,4-Diol., (+-)-2-Methyl-2,4-pentanediol, 1,1,3-Trimethyltrimethylenediol, 2,4-Dihydroxy-2-methylpentane, 2,4-Pentanediol, 2-methyl-, 2-Methyl pentane-2,4-diol, 2-Methyl-2,4-pentanediol, 4-Methyl-2,4-pentanediol, Diolane, Hexylene glycol, Isol, Pinakon, alpha,alpha,alpha'-Trimethyltrimethylene glycol, HGL, 1, 1, 3-Trimethyl-Triethylenediol, Diacetone Glycol, Methylamilene Glycol, 2, 4-Dihydroxy-2-Methyl-Penthane, 2-Methyl-Penthane-2, 4-Diol, 2-Hexyl-1,3-dioxolan-2-one, Hexylene Glycol, HG, 2,4-Dihydroxy-2-methylpentane, 2-Methyl-2,4-, pentanediol, 2-Methylpentane-2,4-diol, Pentane-2,4-, diol, 2-methyl,



Hexylene Glycol also has a low viscosity that makes it easier to incorporate.
The chemical formula of Hexylene Glycol is C6H14O2.
Hexylene Glycol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.


Hexylene Glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.
Hexylene Glycol is 2-methyl-2,4-pentanediol.
Hexylene Glycol is used as coupling agent.


Hexylene Glycol offers low flammability and low evaporation rate.
Hexylene Glycol possesses low surface tension.
Hexylene Glycol exhibits very good solvency.


Hexylene Glycol is a clear, colorless liquid that is used in many personal care and cosmetic formulations.
Hexylene Glycol′s a category of glycol often utilized as a solvent, humectant, and an agent to control viscosity.
Hexylene Glycol, alternative to PG or DEG or MEG in paint formulation in lowering total VOC content.


Hexylene Glycol is a small molecular weight surfactant, widely used as an industrial coating solvent, does not cause adverse health or environmental effects.
Hexylene Glycol is commonly used in the cosmetic and personal care industry, where it functions as a solvent and a humectant in products like moisturisers, lotions, and hair care products.


Additionally, Hexylene Glycol has applications in perfumes, as a fragrance fixative, and in the production of various chemicals and coatings.
Hexylene Glycol is famous for its excellent solvency among a wide variety of materials and is popular in skin care formulas due to its ability to improve the texture.


Hexylene Glycol has viscosity-reducing properties that allow it to thin out heavy, thick formulations and produce smooth spreadability.
Studies indicate Hexylene Glycol also exhibits antimicrobial properties.
Hexylene Glycol floats and mixes slowly with water.


Hexylene Glycol is a clear, colorless liquid.
The principal end uses of Hexylene Glycol include industrial solvent, chemical intermediate, cosmetics, excipient in pharmaceuticals, paints and coatings.
Hexylene Glycol is available in technical grade and NF grade.


Hexylene Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
Hexylene Glycol has a low evaporation rate and it is completely miscible with water.
Hexylene Glycol largely acts as a solvent, humectant, and viscosity agent.


Decades of research have established Hexylene Glycol as a safe and effective ingredient.
Hexylene Glycol dissolves other ingredients in a product and enhances its stability and texture.
Hexylene Glycol is considered safe for use in cosmetics when used in compliance with regulations and guidelines.


Hexylene Glycol is a diol (with two hydroxy groups at 2 and 4 positions), a colorless liquid with a mildly sweet odor and oily consistency.
In nature, Hexylene Glycol is found in the tobacco plant (Nicotiana tabacum).
For industrial purposes Hexylene Glycol is formed from the achiral reagents, diacetone alcohol, and hydrogen, producing equal amounts of enantiomeric products.


Commercial Hexylene Glycol contains > 99% 2-methyl-2,4-pentanediol and is described as a racemic mixture containing equal amounts of two enantiomers.
Hexylene Glycol is a small molecular weight surfactant.
Hexylene Glycol also goes by its chemical compound name: 2-Methyl-2,4-pentanediol.


As a raw material, Hexylene Glycol is a clear liquid.
Hexylene Glycol is safe for pregnant women and does not cause allergies.
Hexylene Glycol is a biodegradable, colorless liquid that is miscible with water and mainly used as a solvent or coupling agent


Hexylene Glycol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.
Hexylene Glycol is fully miscible in water and has the chemical formula C6H14O2.
Hexylene Glycol is a compound that appears in a large number of products that are used commercially and industrially.


Hexylene Glycol is a clear, practically colorless, liquid.
Hexylene Glycol is characterized as a clear, colorless, and odorless liquid that finds extensive use in numerous industries, such as cosmetics and personal care products.


Hexylene Glycol helps to maintain moisture and improve the texture of these products.
Hexylene Glycol is considered safe for use in cosmetics when used in accordance with regulations and guidelines.
Hexylene Glycol is a chemical compound used in various industries, including cosmetics and personal care products.


Hexylene Glycol serves as a solvent and a humectant in these products, helping to retain moisture and improve their texture.
2-methylpentane-2,4-diol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).
Hexylene Glycol, also known as 2-Methyl-2,4-pentanediol, is an organic compound that can be classified as a glycol.


Glycols are a class of alcohols that contain two hydroxyl groups, which can also be called a diols.
Hexylene Glycol is a clear, hygroscopic liquid with a mild, sweet odor.
Hexylene Glycol is most often synthetically produced.


Hexylene Glycol is manufactured by the condensation of 2 molecules of acetone to produce diacetone alcohol, which is further hydrogenated to produce Hexylene Glycol.
This is then purified.


Hexylene Glycol is a clear, colorless liquid chemical compound with the molecular formula C6H14O2.
Hexylene Glycol belongs to a class of chemicals known as glycols, which are often used as solvents, humectants, and chemical intermediates in various industrial applications.


Hexylene Glycol, from Solvay, is an oxygenated solvent derived from acetone which has two alcohol functions.
This speciality ingredient, Hexylene Glycol, demonstrates a low evaporation rate and is completely miscible with water.
Hexylene Glycol (also known as HGL, 2-methyl pentane-2,4-diol, pinakon and Diolane) is a clear, colourless liquid with a characteristic odour.


Hexylene Glycol has the chemical formula C6H14O2 and is fully miscible in water.
Hexylene Glycol is an ingredient used in skincare and cosmetic products to help improve the texture and sensory feel of the formulation.
Hexylene Glycol functions as a surfactant, emulsifier, and a viscosity-reducing agent.


Hexylene Glycol is an oily colorless liquid with a mild sweet odor.
Hexylene Glycol floats and mixes slowly with water.
Hexylene Glycol is an oily colorless liquid with a mild sweet odor.


Hexylene Glycol is fully miscible in water and has the chemical formula C6H14O2.
Hexylene Glycol is a compound that appears in a large number of products that are used commercially and industrially
Hexylene Glycol has a low evaporation rate and it is completely miscible with water.


Similar to other glycols, Hexylene Glycol's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable.
Hexylene Glycol is a synthetic substance added to many cosmetics.
Hexylene Glycol is an aroma compound and has a preservative effect.


At the same time, Hexylene Glycol is also a cleaning agent and detergent.
The most important, however, is the emulsifying property of this glycol.
It is thanks to this that Hexylene Glycol has an influence on the consistency of the product.



USES and APPLICATIONS of HEXYLENE GLYCOL:
Hexylene Glycol is mainly used as a solvent or coupling agent.
Hexylene Glycol is a potential substitute for glycol ethers.
Hexylene Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.


Hexylene Glycol can also be used as a building block in chemical synthesis.
In addition to skin care, Hexylene Glycol is used in other beauty products including hair care and makeup.
Hexylene Glycol has been backed as a safe ingredient for decades with reported concentrations up to 25% in personal care products (though most skin care formulas use much lower amounts than that, especially in preservative blends).


That’s why Hexylene Glycol is commonly used in many cosmetics, e.g. shampoos, shower gels, and soaps.
Thanks to Hexylene Glycol, products are better adapted to the needs of consumers and meet their expectations.
Therefore, the addition of Hexylene Glycol can turn an ordinary cosmetic into something that will be used with real pleasure.


Hexylene Glycol is a compound that appears in a large number of products that are used commercially and industrially.
Hexylene Glycol is used widely across skincare, hair care, and makeup to enhance spreadability, thin out overly thick formulas, and ensure actives are fully dissolved and dispersed.


Hexylene Glycol also has some antimicrobial effect and can enhance the efficacy of certain preservatives.
Hexylene Glycol is used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products at concentrations ranging from 0.1% – 25%.


Hexylene Glycol as a surfactant helps to cleanse and moisturize the skin as well as thinning out the formulation to improve absorption, texture and allow other ingredients to work better.
Hexylene Glycol is also used as a chemical intermediate in chemical syntheses, downhole lubricant for natural gas and oil fields, hydraulic fluid, antifreeze, fuel additive, the solvent in dyes and inks, leather and textile processing, industrial and household cleaners, and in cosmetics.


Hexylene Glycol is also used as a chemical intermediate, which accounts for approximately 20% of its consumption, and another 10% is used on oil and natural-gas fields where it is both a down hole lubricant, and a grinding and extraction aid.
Hexylene Glycol is also employed as an antifreeze, and as a coupling agent for hydraulic fluids.


Hexylene Glycol is a moisturising, and setting, agent in the manufacture of textiles and can also be found in the cosmetics industry where it is a component of fragrances and bath, hair, and soap preparations.
Hexylene Glycol also has a role as a wetting agent in pesticide formulations and is a solvent in the preparation of dyes.


Hexylene Glycol is used for pesticide stabilizer, diesel antifreezer, solvent, spicery, disinfectant,fabric penetration agent and coupler , paper and leather processing auxiliary agent, emulsifier, the additive of fuel and lubricant, etc.
Hexylene Glycol is mainly used as a solvent or coupling agent.


Hexylene Glycol is a potential substitute for glycol ethers.
Hexylene Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexylene Glycol can also be used as a building block in chemical synthesis.


Hexylene Glycol is a highly soluble advanced organic solvent, which can be used in the production of metal surface treatment agents, rust and oil removal additives, textile auxiliaries, coatings and latex paints, cosmetics, pesticides, biochemical engineering, photosensitive materials, synthetic perfumes and other fields.


Hexylene Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexylene Glycol can also be used as a building block in chemical synthesis.
Hexylene Glycol is mainly used as a solvent or coupling agent.


Moreover, Hexylene Glycol acts as a reagent in the synthesis of diverse chemicals.
With regard to scientific research applications, Hexylene Glycol serves as a solvent to extract an array of compounds from plant and animal tissues.
Hexylene Glycol′s also employed as a reagent in the creation of various chemicals, including agrochemicals and fragrances.


The largest end use for Hexylene Glycol is in industrial coatings, as a solvent plasticizer in varnishes, lacquers, paints, and paint strippers, accounting for about 45% of the total production.
Hexylene Glycol is often used in preservative blends that contain phenoxyethanol because it boosts the efficacy of this preservative, allowing lower amounts to be used, which reduces the risk skin will have a sensitised response.


Hexylene Glycol is a cosmetic material for FDA regulated product use.
In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products.


In the realm of cosmetics and personal care products, Hexylene Glycol functions as a preservative.
Hexylene Glycol′s a humectant that aids in skin moisture retention and enhances skin texture and appearance.
Hexylene Glycol operates by forming a barrier on the skin to impede moisture loss.


Additionally, Hexylene Glycol helps to decrease the skin′s surface tension, thereby facilitating the penetration of other ingredients into the skin.
Hexylene Glycol is mainly used as a solvent or coupling agent.
Hexylene Glycol is a potential substitute for glycol ethers.



WHAT IS HEXYLENE GLYCOL USED FOR?
Hexylene Glycol serves many functional benefits in skin care, hair care, and cosmetic products.

*Skin care:
Hexylene Glycol is primarily used in skin care to improve the sensory feel and texture of the products.
Hexylene Glycol also attracts and retains moisture on the surface of the skin, keeping it hydrated and nourished.
Hexylene Glycol is often found in products like toners and cleansers


*Hair care:
Hexylene Glycol is used as a viscosity agent and solvent to improve the texture and stability of formulations.
Hexylene Glycol also acts as an emollient in shampoos and conditioners to provide hydration to the shafts


*Cosmetic products:
Hexylene Glycol works to dissolve other ingredients present in a formulation and enhance the texture of the final product.
Since it has low viscosity, Hexylene Glycol is a useful ingredient in products like foundations, primers, and concealers



ORIGIN OF HEXYLENE GLYCOL:
Hexylene Glycol is typically synthesized by the reaction of ethylene oxide with n-butanol or by the hydration of 1,5-hexadiene.
Hexylene Glycol is later purified by distillation or other methods to obtain the final Hexylene Glycol.



WHAT DOES HEXYLENE GLYCOL DO IN A FORMULATION?
*Humectant
*Solvent
*Viscosity controlling



IS HEXYLENE GLYCOL VEGAN?
Hexylene Glycol is considered to be a vegan ingredient as it is made synethically made from oils and natural gas.
If you are looking for a vegan product, always make sure that the other ingredients in Hexylene Glycol are vegan and that the brand is cruelty-free.



SCIENTIFIC FACTS OF HEXYLENE GLYCOL:
Butylene Glycol, or 1,3-Butanediol, dissolves most essential oils and synthetic flavoring substances.
Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are glycols or glycol ethers.
Glycols are a class of alcohols that contain two hydroxyl groups which are also called a diols.



PROPERTIES OF HEXYLENE GLYCOL:
*Purity (% by weight) : ≥ 99,5
*Appearance at 20°C : clear liquid free from suspended materials
*Density at 20°C (g/cm3) : 0,920 - 0,923
*Boiling point at 1013 Pa : 197,5°C
*Flash point (closed cup) : 97°C
*Water solubility at 20°c : complete
*Hansen Solubility Parameters at 25°C: δt = 25,2; δd = 15,8; δp = 8,4; δh = 17



SAFETY PROFILE OF HEXYLENE GLYCOL:
Hexylene Glycol is generally considered safe for use in cosmetic products.
Hexylene Glycol does not cause skin irritation and sensitization and is not known to be comedogenic.
However, as with any ingredient, some individuals may have an allergic reaction or sensitivity to it, so Hexylene Glycol is always recommended to patch test products before use.
Lastly, Hexylene Glycol is vegan and can be considered halal, but it is best to check with the supplier.



ALTERNATIVES OF HEXYLENE GLYCOL:
*PROPYLENE GLYCOL,
*BUTYLENE GLYCOL,
*GLYCERIN



HOW IS HEXYLENE GLYCOL PRODUCED?
Hexylene Glycol is formed from the achiral reagents hydrogen and diacetone alcohol.



HOW IS HEXYLENE GLYCOL STORED AND DISTRIBUTED?
Hexylene Glycol is stored in bulk storage or stainless steel drums and is transported by tank truck.
Hexylene Glycol is classed as non-hazardous for air, sea, and road freight but is classed as an irritant.
Hexylene Glycol has a specific gravity of 0.925 and a flash point of 93 °C (closed cup).



WHAT IS HEXYLENE GLYCOL USED FOR?
The single largest user of Hexylene Glycol is the industrial coatings industry which uses approximately 45% of the HGL produced world-wide.
Hexylene Glycol is a component in lacquers and varnishes, and is a solvent plasticiser in surface coatings.
Hexylene Glycol is also a component in both oil and water- based paints, and in paint strippers.



HEXYLENE GLYCOL AT A GLANCE:
*Solvent that produces smooth spreadability and pleasing skin care textures
*Viscosity-reducing properties allow Hexylene Glycol to thin out heavy, thick formulations
*Shows up in a wide variety of skin care, hair care, and makeup products
*As a raw material, Hexylene Glycol is clear liquid
*Backed by decades of research as a safe ingredient



BENEFITS OF HEXYLENE GLYCOL:
Hexylene Glycol offers several benefits in various applications, particularly in cosmetics and personal care products:

*Humectant:
Hexylene Glycol helps to retain moisture, which is essential for skin and hair health.
Hexylene Glycol can keep these products from drying out, ensuring that they remain effective and pleasant to use.

*Solvent:
Hexylene Glycol functions as a solvent, helping to dissolve and blend other ingredients in cosmetics and personal care products.
This facilitates the formulation of moisturisers, lotions, and other beauty products.

*Texture Improvement:
Hexylene Glycol can enhance the texture of skincare and hair care products, making them smoother and easier to apply.
This contributes to a more luxurious and user-friendly experience.

*Fragrance Fixative:
In the perfume industry, Hexylene Glycol is used as a fixative, helping to stabilize and prolong the scent of fragrances.
This ensures that the fragrance remains consistent and long-lasting.

*Skin-Friendly:
Hexylene Glycol is considered safe for use in cosmetics and personal care products, as it has low skin irritation potential.
Hexylene Glycol is typically well-tolerated by most individuals.

*Versatility:
Its versatility makes Hexylene Glycol suitable for a wide range of products, including moisturizers, shampoos, conditioners, and perfumes.



IS HEXYLENE GLYCOL SAFE?
The safety of Hexylene Glycol has been assessed by the Cosmetic Ingredient Review Expert Panel.
The Cosmetic Ingredient Review Expert Panel is responsible for the independent evaluation of the safety and efficacy of skincare and cosmetic ingredients.
The Expert Panel evaluated the scientific data and concluded that Hexylene Glycol is safe for use in cosmetics and personal care products.



FEATURES OF HEXYLENE GLYCOL:
*Solvent,
*intermediate



THE GOOD:
Hexylene Glycol helps to improve the texture and feel of skincare and cosmetic formulations.
Hexylene Glycol also has an added benefit of acting as a protective barrier for the skin.


THE NOT SO GOOD:
Hexylene Glycol can be a mild irritant in high concentrations.


WHO IS HEXYLENE GLYCOL FOR?
All skin types except those that have an identified allergy to Hexylene Glycol.


SYNERGETIC INGREDIENTS:
Hexylene Glycol works well with most ingredients.


KEEP AN EYE ON:
Nothing to keep an eye on here.



WHAT ARE THE FUNCTIONS OF HEXYLENE GLYCOL?
Hexylene Glycol is added to cosmetics and skincare products based on its functions as a surfactant, an emulsifier, and a viscosity-reducing agent.

*SURFACTANT
Surfactant is the short term for surface active agents.
Surfactants are compounds that lower the surface tension between two substances.
In skincare products, surfactants work to lift dirt, oil and fats from the skin, allowing them to be washed away.

This is possible because while one end of the surfactant molecule is attracted to water, the other end is attracted to oil.
Thus, surfactants attract the oil, dirt, and other impurities that have accumulated on your skin during the day and wash them away.
Due to these properties, Hexylene Glycol can be found in many different cleansers and body washes.


*EMULSIFIER
Hexylene Glycol also functions as an emulsifier.
An emulsifier is needed for products that contain both water and oil components, for example, when oils are added to a water-based formula.
When shaking stops, however, the two phases can start to separate.

To address this problem, an emulsifier like Hexylene Glycol can be added to the system, which helps the droplets remain dispersed and produces an even and stable formulation.

As an emulsifier, Hexylene Glycol consists of a water-loving hydrophilic head and an oil-loving hydrophobic tail.
The hydrophilic head is attracted to the water and the hydrophobic tail to the oil.
Once again, Hexylene Glycol reduces the surface tension by positioning itself between the oil and water, which has a stabilizing effect on the product.


*THINNING
Finally, Hexylene Glycol functions as a viscosity-reducing agent.
The term viscosity corresponds to the concept of “thickness”, for example, honey has a higher viscosity than water.
As a viscosity-reducing agent, Hexylene Glycol works to thin out heavy formulations and create a thinner, more spreadable product.



PHYSICAL and CHEMICAL PROPERTIES of HEXYLENE GLYCOL:
Molecular Weight： 118.174
Exact Mass： 118.17
EC Number： 203-489-0
ICSC Number： 0660
NSC Number： 8098
UN Number： 1993
DSSTox ID： DTXSID5021885
Color/Form： Liquid|Colorless liquid
HScode： 2905399090
PSA： 40.46000
Boiling Point: 197.5°C
Melting Point: -50°C
pH: 7.0

Solubility: Highly soluble in water
Viscosity: Low
XLogP3： 0.00
Appearance： Hexylene glycol is an oily colorless liquid with a mild sweet odor.
Floats and mixes slowly with water.
Density： 0.92 g/cm3
Melting Point：-50 °C
Boiling Point：198 °C @ Press: 760 Torr
Flash Point：93.9±0.0 °C
Refractive Index：1.447
Water Solubility：Miscible
Storage Conditions：Separated from strong oxidants and strong acids.
Vapor Pressure：0.05 mmHg

Vapor Density：
Relative vapour density (air = 1): 4.1
Flammability characteristics： Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Explosive limit： Explosive limits , vol% in air: 1.2-8.1
Odor：Mild sweetish
Henrys Law Constant：
Henry's Law constant = 4.06X10-7 atm-cu m/mol at 25 °C (est)
Experimental Properties：
Dipole moment: 2.8
Heat of formation = -5.3476X10+8 J/kmol
Triple point temperature = 223.15 °C; triple point pressure: 9.5609X10-6 Pa
Hydroxyl radical reaction rate constant = 2.77X10-11 atm-cu m/mol at 25 °C

Air and Water Reactions： Hygroscopic.
Water soluble
Reactive Group：Alcohols and Polyols
Reactivity Profile： HEXYLENE GLYCOL is incompatible with the following:
Strong oxidizers, strong acids.
Autoignition Temperature： 583 °F
Autoignition temp = 579 K|306 °C
Heat of Combustion： Standard net heat of combustion = -3.4356x10+9 J/kmol
Flammable Limits： Flammability limits = 1.3-9 vol%
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Heat of Vaporization： 13.7 kcal/mol at the boiling point
Critical Temperature & Pressure：
Critical temp = 621 K
Critical pressure = 4.01X10+6 Pa

Molecular Weight: 118.17
XLogP3-AA: 0.3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 2
Exact Mass: 118.099379685
Monoisotopic Mass: 118.099379685
Topological Polar Surface Area: 40.5 Ų
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 68.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical name (CAS): 2-methyl-2,4-pentanediol
CAS number: 107-41-5
Structural formula: CH3–CH(OH)–CH2–C(OH)(CH3)2
Molecular formula: C6H14O2
Molecular weight: 118.18
Melting point: –40°C
Boiling point: 195–200°C
Density at 20°C: 0.920–0.923 g/cm3
Vapour pressure at: 20°C 0.06 hPa
log Pow*: –0.14
CAS number: 107-41-5
EC index number: 603-053-00-3
EC number: 203-489-0
Grade: NF

Hill Formula: C₆H₁₄O₂
Molar Mass: 118.18 g/mol
HS Code: 2926 90 70
Density: 0.922 g/cm3 (20 °C)
Explosion limit: 1 - 9.9 %(V)
Flash point: 94 °C
Ignition temperature: 425 °C
Melting Point: -40 °C
pH value: 6.0 - 8.0 (118.2 g/l, H₂O, 25 °C)
Vapor pressure: 0.03 hPa (20 °C)
Physical state: liquid
Color: colorless
Odor: sweet, mild
Melting point/freezing point:
Melting point/range: -40 °C - lit.

Initial boiling point and boiling range: 197 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 7,4 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 94 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 6,0 - 8,0 at 118,2 g/l at 25 °C
Solubility:
Easily soluble in cold water.
Soluble in diethyl ether.
Soluble in alcohol, lower aliphatic hydrocarbons.
Soluble in a variety of organic solvents.
Miscible with fatty acids
Specific Gravity 20/20 °C:0.9232

Distillation Range at 760 mm Hg (IP) °C:196.4
Distillation Range at 760 mm Hg (DP) °C:198.2
Purity, % w/w:99.62
Acidity as acetic Acid, % w/w: 0.0010
Water, % w/w: 0.018
Melting point: −40 °C(lit.)
Boiling point: 197 °C(lit.)
Density: 0.925 g/mL at 25 °C(lit.)
vapor density: 4.1 (vs air)
vapor pressure: 0.02 mm Hg ( 20 °C)
refractive index: n20/D 1.427(lit.)
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 36 mPa.s at 20 °C

Water solubility ca.: 118,2 g/l at 20 °C
Partition coefficient: n-octanol/water:
log Pow: 0,58 - (Lit.), Bioaccumulation is not expected.
Vapor pressure: 0,03 hPa at 20 °C
Density: 0,925 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information
Relative vapor density: 4,08 - (Air = 1.0)
Molar Weight: 118.176g/mol
Melting Point: -40 °C
Boiling Point: 196 °C

Flash Point: 93 °C
Density: 0.925
Forms: Liquid (clear)
Chemical formula: C6H14O2
Molar mass: 118.176 g•mol−1
Appearance: colourless liquid
Odor: mild, sweetish
Density: 0.92 g/mL
Melting point: −40 °C (−40 °F; 233 K)
Boiling point: 197 °C (387 °F; 470 K)
Solubility in water: miscible[1]
Vapor pressure: 0.05 mmHg (20°C)
Flash point: 98.3 °C (208.9 °F; 371.4 K)
Explosive limits: 1.3%-7.4%
Appearance: colorless clear liquid (est)
Physical state and Appearance:Liquid.

Odor:Sweetish
Molecular Weight:118.18 g/mole
Color:Colorless
Boiling Point:197 (386.6) - 198° C
Melting Point:-50 - (-58)
Specific Gravity:0.9254 @ 17 C; 0.9234 @ 20 C (Water = 1)
Vapor Pressure: 0.05 mm of Hg (@ 20)
Vapor Density: 4.1 (Air = 1)
Odor Threshold: 50 ppm
Dispersion Properties: See solubility in water, diethyl ether
Flash point: 201 °F
storage temp.: 2-8°C
solubility: H2O: 1 M at 20 °C, clear, colorless
pka: 14.72±0.20(Predicted)
CAS DataBase Reference: 5683-44-3(CAS DataBase Reference)

Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.92400 @ 25.00 °C.
Melting Point: -40.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density: 4.1 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 0.004 (est)
Soluble in: alcohol
water, 3.256e+004 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)
Molecular Weight: 118.2 g/mol
Empirical Formula: C6H14O2

Appearance: Colorless, Liquid
Freezing Point: -50°C (-58.0°F)
Boiling Point: @ 760mm Hg 196°C (385°F)
Flash Point: Closed Cup 96°C (205°F)
Autoignition Temperature: 425°C (797°F)
Density @ 20°C: 0.924 kg/L, 7.71 lb/gal
Vapor Pressure: @ 20°C 0.05 mmHg
Evaporation Rate: (nBuAc = 1) 0.007
Solubility in Water: @ 20°C Miscible
Surface Tension @ 20°C: 33.1 dynes/cm
Refractive Index @ 20°C: 1.426
Viscosity @ 20°C: 38.9 cP
Lower Explosive Limit: 1.0 v/v%
Upper Explosive Limit: 9.9 v/v%
Conductivity @ 20°C: 3x106 pS/m

Dielectric Constant @ 20°C: ≈7.7
Specific Heat @ 20°C: 2.20 kJ/kg/°C
Heat of Vaporization @ normal boiling point: 435 kJ/kg
Heat of Combustion @ 25°C: 29875 kJ/kg
Odor Threshold: 50 ppm
Molecular Weight 118.2 g/mol
Empirical Formula C6H14O2
Appearance Colorless
Liquid
Freezing Point -50°C (-58.0°F)
Boiling Point @ 760mm Hg 196°C (385°F)
Flash Point – Closed Cup 96°C (205°F)
Autoignition Temperature 425°C (797°F)

Density @ 20°C 0.924 kg/L
7.71 lb/gal
Vapor Pressure @ 20°C 0.05 mmHg
Evaporation Rate (nBuAc = 1) 0.007
Solubility in Water @ 20°C Miscible
Surface Tension @ 20°C 33.1 dynes/cm
Refractive Index @ 20°C 1.426
Viscosity @ 20°C 38.9 cP
Lower Explosive Limit 1.0 v/v%
Upper Explosive Limit 9.9 v/v%
Conductivity @ 20°C 3x106 pS/m
Dielectric Constant @ 20°C ≈7.7
Specific Heat @ 20°C 2.20 kJ/kg/°C

Heat of Vaporization @ normal boiling point 435 kJ/kg
Heat of Combustion @ 25°C 29875 kJ/kg
Odor Threshold 50 ppm
CAS NO:107-41-5
EINECS NO:203-489-0
Molecular Formula:C6H14O2
Molecular Weight:118.1742
InChI:InChI=1/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3
Density:0.96g/cm3
Melting Point:-40ºC
Boiling Point:197.5°C at 760 mmHg
Flash Point:93.9°C
Water Solubility:soluble
Vapour Pressure:0.0961mmHg at 25°C

Refractive Rate:n20/D1.427(lit.)
Storage Condition:2-8°C
Appearance:Clear colorless Slightly Viscous Liquid
Odor:Ammonia-like
PH Value:6-8(25ºC,1MinH2O)
Explosive Limit:1-9.9%(V)
Sensitivity:Hygroscopic
Stability: Incompatible with strong oxidizing agents, strong acids,strong reducing agents.
Physical description: Colorless liquid with a mild, sweetish odor.
Boiling point: 388°F
Molecular weight: 118.2
Freezing point/melting point: -58°F (sets to glass)
Vapor pressure: 0.05 mmHg
Flash point: 209°F
Specific gravity: 0.923

Lower explosive limit (LEL): 1.3% (calc)
Upper explosive limit (UEL): 8.1% (calc)
NFPA health rating: 2
NFPA fire rating: 1
NFPA reactivity rating: 0
Appearance: colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.92400 @ 25.00 °C.
Melting Point: -40.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density: 4.1 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 0.004 (est)
Soluble in: alcohol
water, 3.256e+004 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)



FIRST AID MEASURES of HEXYLENE GLYCOL:
-Description of first-aid measures:
*General advice
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of HEXYLENE GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of HEXYLENE GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of HEXYLENE GLYCOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 240 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of HEXYLENE GLYCOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store under inert gas.
Hygroscopic.



STABILITY and REACTIVITY of HEXYLENE GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available