Aerosil 200 Pharma is a type of fumed silica, specifically designed and manufactured for pharmaceutical applications.
Aerosil 200 Pharma is a fine powder consisting of nano-sized particles of amorphous silicon dioxide.
Aerosil 200 Pharma is characterized by its high purity, narrow particle size distribution, and large surface area, making it suitable for various pharmaceutical formulations.
CAS Number: 7631-86-9
EC Number: 231-545-4
Synonyms: Fumed silica, Colloidal silicon dioxide, Silicon dioxide nanoparticles, Pyrogenic silica, Cab-O-Sil, Aerosil, Sipernat, Silicic anhydride, Synthetic amorphous silica, White carbon, Nanosilica, Silica gel, Amorphous silica, Silicon dioxide colloidal, Silicon dioxide gel, Silica dioxide, Silicic acid, SiO2, Silica aerosol, Silica nanoparticles, Silica powder, Silica flour, Silica dust, Silica fume, Silica sol, Spherical silica, Microsilica, Nano-silica, Siliceous earth, Silicious earth, Precipitated silica, Diatomaceous earth, Siliceous silica, Silica stone, Quartz, Diatomite, Diatomaceous silica, Diatomaceous earth silica, Silica rock, Silicon oxide, Silicious oxide, Silicium dioxide, Aerosil powder, Fumed oxide, Silica microspheres, Silicon colloidal, Silica colloid, Silica micro powder, Silica micron powder, Silica submicron powder, Silica nanoparticles powder, Silica ultrafine powder, Silica nanometer powder, Silica nanoscale powder, Silica nanosized powder, Silica nanopowder, Silica ultrafine particles, Silica nanoscale particles, Silica nanoparticles dispersion, Silica colloidal dispersion, Silica aqueous dispersion, Silica sol-gel, Silica sol dispersion.
APPLICATIONS
Aerosil 200 Pharma is widely used as a pharmaceutical excipient in solid dosage forms such as tablets and capsules.
Aerosil 200 Pharma serves as a glidant, improving the flow properties of powders during tablet compression and capsule filling.
Aerosil 200 Pharma acts as an anti-caking agent, preventing the adhesion and clumping of fine particles in powdered formulations.
Aerosil 200 Pharma is commonly incorporated into oral solid formulations to enhance powder compressibility and tablet hardness.
Aerosil 200 Pharma is used in direct compression formulations to improve blend uniformity and tablet disintegration.
Aerosil 200 Pharma is added to granulation blends to improve granule flowability and uniformity.
Aerosil 200 Pharma is used in dry powder inhaler formulations to enhance aerosolization and drug delivery to the lungs.
Aerosil 200 Pharma serves as a carrier for active pharmaceutical ingredients (APIs), improving their dispersion and bioavailability in solid dosage forms.
Aerosil 200 Pharma is used in topical formulations such as creams and ointments as a rheology modifier and thickening agent.
Aerosil 200 Pharma enhances the stability and texture of topical formulations, preventing phase separation and improving spreadability.
Aerosil 200 Pharma is added to topical gels and suspensions to provide thixotropic properties, ensuring ease of application and uniform distribution on the skin.
The powder is used in oral liquid formulations such as suspensions and emulsions as a suspension aid and viscosity enhancer.
Aerosil 200 Pharma improves the stability and sedimentation resistance of oral liquid formulations, ensuring uniform dosing.
Aerosil 200 Pharma is used in antacid suspensions to prevent settling of the active ingredients and maintain uniformity throughout the product shelf life.
Aerosil 200 Pharma is incorporated into dental formulations such as toothpaste and mouthwash to enhance texture and abrasive properties.
Aerosil 200 Pharma is used in topical powders and dusting powders to improve flowability and prevent caking.
Aerosil 200 Pharma serves as a carrier for active ingredients in powdered inhalation formulations, facilitating their dispersion and delivery to the respiratory tract.
Aerosil 200 Pharma is used in suppository formulations as a lubricant and mold release agent, improving product uniformity and ease of administration.
Aerosil 200 Pharma is added to parenteral formulations such as injectable suspensions and emulsions as a stabilizer and viscosity modifier.
Aerosil 200 Pharma enhances the stability and physical integrity of parenteral formulations, preventing particle aggregation and phase separation.
Aerosil 200 Pharma is used in topical spray formulations as a thickening agent and suspension aid, ensuring uniform distribution of the active ingredients.
Aerosil 200 Pharma is employed in wound care formulations such as hydrogels and dressings to enhance moisture retention and promote healing.
Aerosil 200 Pharma serves as a flow aid and anti-settling agent in veterinary formulations such as oral suspensions and powders.
Aerosil 200 Pharma is used in dietary supplements and nutraceutical formulations to improve flowability and prevent caking.
Aerosil 200 Pharma plays a critical role in enhancing the performance, stability, and patient acceptability of a wide range of pharmaceutical formulations across various dosage forms.
Aerosil 200 Pharma is utilized in the formulation of gastroretentive dosage forms to prolong gastric residence time and enhance drug absorption.
Aerosil 200 Pharma is added to controlled-release formulations to modulate drug release kinetics and achieve desired therapeutic outcomes.
Aerosil 200 Pharma is used in taste-masking formulations to improve the palatability of oral dosage forms, masking unpleasant tastes and odors.
Aerosil 200 Pharma is incorporated into chewable tablets and lozenges to enhance mouthfeel and disintegration properties.
Aerosil 200 Pharma is used in enteric-coated formulations to protect acid-sensitive drugs from degradation in the stomach and facilitate drug release in the intestines.
Aerosil 200 Pharma is employed in sustained-release formulations to provide a gradual and prolonged release of the active ingredient over time.
Aerosil 200 Pharma is used in topical skincare formulations such as lotions and creams to enhance texture and stability.
Aerosil 200 Pharma serves as a thickening agent and emulsion stabilizer in cosmetic formulations, improving product spreadability and shelf life.
Aerosil 200 Pharma is added to sunscreen formulations to improve UV protection and enhance product aesthetics.
Aerosil 200 Pharma is used in hair care products such as shampoos and conditioners to provide viscosity control and conditioning properties.
Aerosil 200 Pharma is incorporated into makeup formulations such as foundations and powders to improve texture and wearability.
Aerosil 200 Pharma is used in wound dressings and bandages to enhance moisture absorption and promote wound healing.
Aerosil 200 Pharma is employed in veterinary formulations such as oral suspensions and topical sprays to improve product stability and performance.
Aerosil 200 Pharma serves as a flow aid and anti-caking agent in animal feed formulations to prevent clumping and ensure uniform mixing.
Aerosil 200 Pharma is added to agricultural formulations such as herbicides and insecticides to improve dispersion and adhesion to plant surfaces.
Aerosil 200 Pharma is utilized in the production of batteries as a conductive additive to enhance electrolyte conductivity and battery performance.
Aerosil 200 Pharma is used in the manufacturing of adhesives and sealants to improve rheological properties and adhesion strength.
Aerosil 200 Pharma serves as a matting agent in paints and coatings to impart a uniform matte finish and enhance scratch resistance.
Aerosil 200 Pharma is employed in the production of printing inks to improve flow properties and print quality.
Aerosil 200 Pharma serves as a reinforcing filler in rubber and elastomer formulations to enhance tensile strength and tear resistance.
Aerosil 200 Pharma is used in the production of silicone rubber and silicone sealants to improve processing and mechanical properties.
Aerosil 200 Pharma is employed in the manufacturing of catalysts and catalyst supports to enhance surface area and catalytic activity.
Aerosil 200 Pharma serves as a carrier for active ingredients in fragrance and flavor encapsulation applications, prolonging their release and enhancing stability.
Aerosil 200 Pharma is used in the production of composite materials such as plastics and composites to improve mechanical properties and dimensional stability.
Aerosil 200 Pharma finds diverse applications across various industries, contributing to product performance, quality, and functionality.
DESCRIPTION
Aerosil 200 Pharma is a type of fumed silica, specifically designed and manufactured for pharmaceutical applications.
Aerosil 200 Pharma is a fine powder consisting of nano-sized particles of amorphous silicon dioxide.
Aerosil 200 Pharma is characterized by its high purity, narrow particle size distribution, and large surface area, making it suitable for various pharmaceutical formulations.
In pharmaceutical applications, Aerosil 200 Pharma is commonly used as a glidant, anti-caking agent, thickening agent, and viscosity modifier in solid and liquid dosage forms.
Aerosil 200 Pharma improves flow properties, enhances powder compressibility, prevents caking and clumping, and provides thixotropic behavior in suspensions and gels.
Due to its high surface area and porosity, Aerosil 200 Pharma also serves as a carrier for active pharmaceutical ingredients (APIs), facilitating their dispersion and improving bioavailability in formulations.
Additionally, it can be utilized as a desiccant to control moisture content in pharmaceutical products, thus enhancing stability and shelf life.
Aerosil 200 Pharma is a fine, white powder with a fluffy texture.
Its particles are extremely small, with an average diameter in the nanometer range.
Aerosil 200 Pharma has a high surface area, contributing to its exceptional adsorption properties.
Aerosil 200 Pharma is odorless and tasteless, making it suitable for pharmaceutical applications.
Aerosil 200 Pharma has a soft, powdery feel and easily disperses in both aqueous and non-aqueous media.
Aerosil 200 Pharma exhibits excellent flowability and is free-flowing when poured.
Aerosil 200 Pharma has a fluffy, non-agglomerated structure, ensuring uniform distribution in formulations.
Its high purity ensures minimal impurities, making it suitable for use in pharmaceutical products.
Aerosil 200 Pharma appears bright white under ambient light, enhancing its aesthetic appeal in formulations.
Aerosil 200 Pharma has a low bulk density, allowing for easy incorporation into formulations without adding significant weight.
Its unique morphology provides a large surface area for interaction with other components in formulations.
Aerosil 200 Pharma is hydrophilic, readily absorbing and retaining moisture in formulations.
Aerosil 200 Pharma imparts thixotropic properties to suspensions and gels, enhancing stability and viscosity.
Aerosil 200 Pharma serves as an effective glidant and anti-caking agent in solid dosage forms, improving powder flow and compressibility.Aerosil 200 Pharma acts as a stabilizer and thickening agent in liquid formulations, preventing sedimentation and phase separation.
Aerosil 200 Pharma enhances the texture and mouthfeel of oral suspensions and emulsions, imparting smoothness and creaminess.
Its uniform particle size distribution ensures consistent performance and reproducibility in formulations.
Aerosil 200 Pharma is chemically inert and compatible with a wide range of pharmaceutical ingredients.
Aerosil 200 Pharma is manufactured using advanced fumed silica technology, ensuring high quality and consistency.
Aerosil 200 Pharma meets stringent pharmaceutical standards and complies with regulatory requirements for purity and safety.
Aerosil 200 Pharma is versatile and finds applications in tablets, capsules, topical creams, ointments, and oral liquids.
Its high adsorption capacity makes it suitable for use as a carrier for active pharmaceutical ingredients (APIs) in solid dosage forms.
Aerosil 200 Pharma is stable under normal storage conditions, with a long shelf life when stored properly.
Aerosil 200 Pharma undergoes rigorous quality control testing to ensure compliance with pharmacopeial specifications and customer requirements.
Aerosil 200 Pharma is a versatile and essential excipient in pharmaceutical formulations, contributing to product quality, performance, and patient satisfaction.
PROPERTIES
Physical Properties:
Appearance: Fine, white powder
Texture: Soft, fluffy
Particle Size: Nano-sized particles (average diameter in nanometers)
Surface Area: High surface area per unit mass
Bulk Density: Low bulk density
Odor: Odorless
Taste: Tasteless
Solubility in Water: Insoluble
Solubility in Organic Solvents: Insoluble in most organic solvents
Hygroscopicity: Low to moderate
Melting Point: Not applicable (amorphous material)
Boiling Point: Not applicable (amorphous material)
pH: Neutral (around 7)
Density: Typically ranges from 150 to 300 kg/m³
Specific Surface Area: Typically ranges from 150 to 400 m²/g
Particle Shape: Spherical or irregular
Refractive Index: Varies depending on particle size and surface treatment
Opacity: Transparent to translucent in thin films
Chemical Properties:
Chemical Formula: SiO2 (amorphous silicon dioxide)
Molecular Weight: ~60.08 g/mol
Composition: Silicon (Si) and Oxygen (O)
Crystal Structure: Amorphous (lacks long-range order)
Chemical Structure: Consists of silicon atoms bonded to oxygen atoms in a three-dimensional network
Hydrophilicity: Hydrophilic surface with strong affinity for water molecules
Hydrophobicity: Can be modified to exhibit hydrophobic properties through surface treatment
Reactivity: Chemically inert under normal conditions
Acid-Base Properties: Neutral pH in aqueous suspensions
Surface Modification: Can be surface-modified with various functional groups to tailor properties
Surface Charge: Negatively charged under neutral pH conditions (due to surface hydroxyl groups)
Thermal Stability: Stable up to temperatures around 400-600°C, depending on specific surface treatment
Electrical Conductivity: Non-conductive
Toxicity: Generally recognized as safe (GRAS) for pharmaceutical and cosmetic applications
Compatibility: Compatible with a wide range of pharmaceutical excipients and cosmetic ingredients
Biodegradability: Non-biodegradable due to its highly stable amorphous structure
FIRST AID
Inhalation:
Remove to Fresh Air:
Immediately move the affected person to an area with fresh air and good ventilation.
Assist Breathing:
If breathing is difficult, provide oxygen if available and trained to do so.
Keep Calm:
Encourage the person to remain calm and avoid exertion.
Seek Medical Attention:
If symptoms persist or worsen, seek medical attention promptly.
Skin Contact:
Remove Contaminated Clothing:
Quickly and gently remove any contaminated clothing, shoes, or accessories.
Wash Skin:
Wash the affected area thoroughly with mild soap and lukewarm water for at least 15 minutes, ensuring complete removal of the substance.
Rinse Thoroughly:
Rinse the skin with copious amounts of water to remove any residual material.
Seek Medical Attention:
If irritation or allergic reaction occurs, seek medical advice promptly.
Eye Contact:
Flush Eyes Immediately:
Immediately flush the affected eye(s) with gently flowing lukewarm water for at least 15 minutes, keeping eyelids open.
Remove Contact Lenses:
If present and easily removable, remove contact lenses after the initial flush.
Continue Flushing:
Continue to flush the eye(s) with water, ensuring thorough rinsing of the eye(s) and eyelids.
Seek Medical Attention:
Seek immediate medical attention, even if symptoms seem minor or if irritation persists after rinsing.
Ingestion:
Do NOT Induce Vomiting:
Do not induce vomiting unless instructed to do so by medical personnel.
Do NOT Give Anything by Mouth:
Do not give anything by mouth to an unconscious person.
Rinse Mouth:
If the person is conscious and able to swallow, rinse their mouth with water and encourage them to drink water slowly.
Seek Medical Attention:
Seek immediate medical attention or contact a poison control center for further guidance.
HANDLING AND STORAGE
Handling:
Personal Protective Equipment (PPE):
Wear appropriate personal protective equipment (PPE) including safety goggles, chemical-resistant gloves, and a lab coat or protective clothing when handling Aerosil 200 Pharma.
Ensure that all PPE is properly fitted and in good condition before use.
Avoid Dust Generation:
Take precautions to minimize dust generation during handling to prevent inhalation of fine particles.
Use handling equipment and procedures that minimize the generation of airborne dust.
Use in Well-Ventilated Areas:
Handle Aerosil 200 Pharma in well-ventilated areas to prevent the buildup of airborne particles.
Use local exhaust ventilation if available to control dust exposure and maintain air quality.
Prevent Spills and Leaks:
Take precautions to prevent spills and leaks during handling and transfer of Aerosil 200 Pharma.
Use appropriate containment measures such as spill trays or spill kits.
Avoid Contact with Eyes and Skin:
Avoid direct contact with eyes, skin, and clothing. In case of contact, follow the first aid measures outlined in the Safety Data Sheet (SDS) or chemical label.
Use Proper Equipment:
Use equipment such as scoops, shovels, or dust-free handling tools to minimize contact and dust generation.
Use containers with tight-fitting lids to prevent contamination and moisture absorption.
Labeling:
Ensure that containers of Aerosil 200 Pharma are properly labeled with the appropriate product name, hazard warnings, and handling instructions.
Clearly mark containers to indicate the contents and any special handling requirements.
Storage:
Store in Cool, Dry Area:
Store containers of Aerosil 200 Pharma in a cool, dry, well-ventilated area away from heat sources and direct sunlight.
Maintain storage temperatures between 15°C and 25°C (59°F and 77°F) to prevent degradation and moisture absorption.
Keep Containers Tightly Closed:
Keep containers of Aerosil 200 Pharma tightly closed when not in use to prevent contamination and moisture absorption.
Ensure that lids are securely tightened to minimize exposure to air and humidity.
Avoid Temperature Extremes:
Avoid exposure to extreme temperatures. Do not allow Aerosil 200 Pharma to freeze or overheat, as it may affect its properties.
Protect containers from excessive heat or cold to prevent damage.
Separate from Incompatible Substances:
Store Aerosil 200 Pharma away from incompatible substances such as strong acids, strong bases, and reactive chemicals.
Follow storage segregation guidelines to prevent cross-contamination and chemical reactions.
Check for Leaks and Damage:
Regularly inspect containers for signs of leaks, damage, or deterioration. Replace damaged containers promptly to prevent spills or accidents.
Conduct periodic inventory checks to ensure proper stock rotation and minimize storage issues.
Follow Manufacturer's Recommendations:
Follow the manufacturer's recommendations for storage conditions and shelf life to maintain product quality and stability.
Adhere to any specific storage instructions provided in the Safety Data Sheet (SDS) or product documentation.
