SYNONYMS 1-Ethyl-2-pyrrolidinone; NEP; 1-éthylpyrrolidine-2-one; 1-Ethylpyrrolidin-2-one;1-Ethylpyrrolidin-2-on; 1-Etilpirrolidin-2-ona; N-Ethylpyrrolidone; N-Ethyl-2-pyrrolidinon; N-Ethylpyrrolidinone; cas no: 2687-91-4

Neosorb 70/70 B is a non-crystallizing liquid sorbitol, also known as D-sorbitol or D-glucitol.
Neosorb 70/70 B is a clear, viscous liquid with a sweet taste and approximately 70% as sweet as sucrose (table sugar).
Neosorb 70/70 B is commonly used as a plasticizer in soft gelatin capsules, improving their flexibility and ease of swallowing.
Neosorb 70/70 B serves as a bulk sweetener in liquid dosage forms, such as syrups and oral solutions, to provide sweetness and palatability.

CAS Number: 50-70-4
EC Number: 200-061-5



APPLICATIONS


Neosorb 70/70 B is commonly used in the production of sugar-free candies and confectionery to provide sweetness and prevent the crystallization of sugar.
Neosorb 70/70 B serves as a versatile bulking agent in sugar-free and low-calorie powdered beverage mixes, enhancing the texture and mouthfeel.
Neosorb 70/70 B finds application in sugar-free jams and spreads, providing sweetness and maintaining the desired consistency.
Neosorb 70/70 B is used in some diabetic-friendly baked goods, such as cookies and muffins, as a sugar substitute to reduce the overall carbohydrate content.

Neosorb 70/70 B is employed in the formulation of some sugar-free and low-calorie frozen desserts, such as ice cream and frozen yogurt, providing sweetness and a smooth texture.
Neosorb 70/70 B is used in the production of sugar-free and reduced-calorie syrups for coffee and tea beverages.
Neosorb 70/70 B is added to certain sugar-free chewing gums and mints to provide sweetness and enhance the overall flavor experience.
Neosorb 70/70 B is utilized in the production of sugar-free and low-calorie fruit-flavored beverages, enhancing taste and drinkability.

Neosorb 70/70 B is used in the formulation of sugar-free and reduced-calorie fruit fillings for pastries and pies.
Neosorb 70/70 B is employed in the production of some sugar-free and low-calorie carbonated beverages, contributing to sweetness and drink appeal.
Neosorb 70/70 B serves as a humectant in certain topical pharmaceutical formulations, like gels and creams, helping to retain moisture and improve skin hydration.

Neosorb 70/70 B is used in some sugar-free and low-calorie dietary supplements, providing sweetness and palatability to powdered formulations.
Neosorb 70/70 B finds application in some sugar-free and low-calorie dressings and sauces, enhancing taste and mouthfeel.
Neosorb 70/70 B is used in the production of certain sugar-free and reduced-calorie fruit-flavored gelatin desserts, contributing to their sweetness and texture.

Neosorb 70/70 B is employed in some sugar-free and low-calorie sports drinks, providing taste and hydration benefits.
Neosorb 70/70 B is used in certain sugar-free and low-calorie protein shakes and meal replacement products to enhance palatability and consumer acceptance.

Neosorb 70/70 B serves as a sugar substitute in some sugar-free and low-calorie nutritional bars, maintaining sweetness and texture.
Neosorb 70/70 B is used in some sugar-free and low-calorie cereal products, enhancing taste and overall product appeal.
Neosorb 70/70 B is employed in the production of sugar-free and low-calorie fruit-flavored lollipops and hard candies.
Neosorb 70/70 B finds application in sugar-free and reduced-calorie fruit-flavored gel candies, enhancing sweetness and chewability.

Neosorb 70/70 B is used in the formulation of some sugar-free and low-calorie dessert sauces and toppings for ice cream and desserts.
Neosorb 70/70 B is employed in the production of sugar-free and low-calorie whipped toppings and dessert creams, providing sweetness and texture enhancement.
Neosorb 70/70 B serves as a substitute for sucrose in some sugar-free and low-calorie sweet baked goods, such as cakes and pastries.

Neosorb 70/70 B is used in certain sugar-free and reduced-calorie breakfast cereals to provide sweetness and texture.
Neosorb 70/70 B finds application in some sugar-free and low-calorie instant drink mixes, enhancing taste and rehydration properties.

Neosorb 70/70 B is utilized in the production of sugar-free and low-calorie fruit-flavored gummy candies, providing sweetness and chewiness.
Neosorb 70/70 B is used in certain sugar-free and reduced-calorie breakfast bars, enhancing taste and texture.
Neosorb 70/70 B is employed in some sugar-free and low-calorie pancake and waffle syrups, offering a sweet breakfast option.

Neosorb 70/70 B serves as a sweetener in some sugar-free and low-calorie flavored water beverages, providing refreshing sweetness.
Neosorb 70/70 B is used in the formulation of sugar-free and reduced-calorie oral rehydration solutions for hydration and electrolyte balance.
Neosorb 70/70 B is employed in some sugar-free and low-calorie fruit-flavored yogurt products, enhancing taste and palatability.

Neosorb 70/70 B is used in the production of sugar-free and low-calorie fruit-flavored energy drinks, contributing to the beverage's sweetness.
Neosorb 70/70 B serves as a sweetening agent in certain sugar-free and low-calorie cocktail mixers, such as margarita and daiquiri mixes.
Neosorb 70/70 B is used in some sugar-free and low-calorie pudding and custard desserts, providing sweetness and creaminess.
Neosorb 70/70 B is employed in the production of sugar-free and low-calorie fruit-flavored water ice and sorbet desserts.

Neosorb 70/70 B is used in certain sugar-free and low-calorie fruit-flavored popsicles, enhancing sweetness and refreshment.
Neosorb 70/70 B serves as a sweetener in some sugar-free and low-calorie fruit-flavored jelly products, enhancing taste and spreadability.
Neosorb 70/70 B is used in the formulation of sugar-free and reduced-calorie fruit-flavored beverage concentrates, allowing dilution as needed.
Neosorb 70/70 B serves as a sweetening agent in some sugar-free and low-calorie caramel and butterscotch-flavored toppings and sauces.
Neosorb 70/70 B is employed in certain sugar-free and low-calorie iced tea and lemonade drink mixes, enhancing taste and drink appeal.

Neosorb 70/70 B is used in the production of sugar-free and reduced-calorie fruit-flavored nutrition shakes and smoothies.
Neosorb 70/70 B is employed in some sugar-free and low-calorie flavored milk products, enhancing sweetness and overall flavor experience.
Neosorb 70/70 B serves as a sweetener in certain sugar-free and low-calorie flavored sparkling water beverages, providing effervescence and sweetness.
Neosorb 70/70 B is used in the formulation of sugar-free and reduced-calorie dessert syrups, such as chocolate and caramel syrups.
Neosorb 70/70 B serves as a sweetening agent in some sugar-free and low-calorie fruit-flavored drinkable yogurts.

Neosorb 70/70 B is used in certain sugar-free and low-calorie fruit-flavored instant oatmeal and cereal cups, enhancing taste and sweetness.
Neosorb 70/70 B is employed in the production of sugar-free and reduced-calorie fruit-flavored snack chips and crisps.
Neosorb 70/70 B is used in some sugar-free and low-calorie salad dressings and vinaigrettes to provide sweetness and balance flavors.
Neosorb 70/70 B serves as a sweetener in certain sugar-free and low-calorie flavored coffee syrups, such as hazelnut and vanilla.
Neosorb 70/70 B is used in the formulation of sugar-free and reduced-calorie fruit-flavored frozen novelties, such as fruit bars and ice cream sandwiches.


Neosorb 70/70 B has various applications in different industries, owing to its properties as a non-crystallizing liquid sorbitol.
Here are its applications:

Pharmaceutical Industry:
Neosorb 70/70 B is used as a plasticizer in the production of soft gelatin capsules, improving their flexibility and ease of swallowing.

Food and Beverage Industry:
Neosorb 70/70 B serves as a bulk sweetener in liquid dosage forms, including syrups, oral solutions, and beverages, providing sweetness without the caloric impact of sucrose (table sugar).

Cosmetic and Personal Care Products:
Neosorb 70/70 B acts as a humectant in semi-solid formulations like creams and ointments, helping retain moisture and preventing drying in cosmetic and personal care products.

Sugar-Free and Low-Calorie Products:
Neosorb 70/70 B is widely used in the formulation of sugar-free and low-calorie food products to cater to health-conscious consumers.

Tooth-Friendly Products:
Neosorb 70/70 B is used in oral care products, such as toothpaste and mouthwash, due to its non-cariogenic properties, meaning it does not contribute to tooth decay.

Diabetic-Friendly Products:
Neosorb 70/70 B's low glycemic index makes it suitable for use in diabetic-friendly food and beverage products.

Bakery and Confectionery:
Neosorb 70/70 B finds application in the bakery and confectionery industry for providing sweetness and texture enhancement in various products.

Nutraceuticals:
Neosorb 70/70 B is used in the production of nutraceuticals and dietary supplements to enhance palatability and sweetness without adding excess calories.

Pharmaceuticals:
Neosorb 70/70 B is utilized in certain pharmaceutical formulations for improving taste and patient compliance, particularly in pediatric medications.

Pet Care Products:
Neosorb 70/70 B is employed in pet care products, such as oral rinses and dental chews, for its flavor-enhancing properties.

Skincare Products:
Neosorb 70/70 B is used in skincare products like lotions and creams to enhance moisturization and improve overall texture.

Beverages:
Neosorb 70/70 B is added to various beverages, including sports drinks and flavored water, to provide sweetness without the use of traditional sugar.

Nutritional Bars and Snacks:
Neosorb 70/70 B is used in the production of nutritional bars and snacks as a bulking agent and to enhance chewability.

Pharmaceutical Syrups:
Neosorb 70/70 B serves as a sweetening agent and suspension stabilizer in certain pharmaceutical syrups and suspensions.

Sugar-Free Desserts:
Neosorb 70/70 B is employed in the formulation of sugar-free desserts like frozen yogurt and sorbets to provide sweetness and enhance mouthfeel.

Printing Inks:
Neosorb 70/70 B is used in the printing industry as a solvent and carrier for certain ink formulations.

Food Fillings and Toppings:
Neosorb 70/70 B is added to certain food fillings and toppings for baked goods to provide sweetness and texture modification.

Non-Crystallizing Sweeteners:
Neosorb 70/70 B is used as a non-crystallizing sweetener in various food applications to maintain product stability and appearance.

Functional Foods:
Neosorb 70/70 B is used in the production of functional foods that require specific sweetening properties without increasing caloric content.

Personal Lubricants:
Neosorb 70/70 B is used in certain personal lubricants for its moisturizing and lubricating effects.

Nutritional Supplements:
Neosorb 70/70 B is employed in the formulation of certain nutritional supplements to enhance palatability and improve overall product acceptance.

Non-GMO Products:
Neosorb 70/70 B is available as a non-GMO ingredient, meeting preferences for natural and non-genetically modified ingredients.

Sugar-Free Mints and Breath Fresheners:
Neosorb 70/70 B is used in the production of sugar-free mints and breath fresheners for its cooling effect and sweet taste.

Liquid Medications:
Neosorb 70/70 B is used as an excipient in liquid medications to enhance palatability and suspend active ingredients.

Sugar-Free Syrups:
Neosorb 70/70 B is employed in the production of sugar-free syrups for pancakes, waffles, and desserts.



DESCRIPTION


Neosorb 70/70 B is a non-crystallizing liquid sorbitol, also known as D-sorbitol or D-glucitol.
Neosorb 70/70 B is a clear, viscous liquid with a sweet taste and approximately 70% as sweet as sucrose (table sugar).

Neosorb 70/70 B is commonly used as a plasticizer in soft gelatin capsules, improving their flexibility and ease of swallowing.
Neosorb 70/70 B serves as a bulk sweetener in liquid dosage forms, such as syrups and oral solutions, to provide sweetness and palatability.

Neosorb 70/70 B acts as a humectant in semi-solid formulations, like creams and ointments, helping retain moisture and preventing drying.
Neosorb 70/70 B is a mixture of sorbitol and other hydrogenated oligomers, making it suitable for various applications in the pharmaceutical and food industries.
As a sugar substitute, Neosorb 70/70 B is used to meet organoleptic requirements by providing natural sweetness in products.
The liquid form of Neosorb 70/70 B offers ease of handling and blending in formulations compared to solid sorbitol forms.

Neosorb 70/70 B is non-GMO (Genetically Modified Organism), meeting specific preferences for natural and non-genetically modified ingredients.
Neosorb 70/70 B is widely used in the formulation of sugar-free and low-calorie products to cater to health-conscious consumers.
Neosorb 70/70 B is compatible with a wide range of other ingredients, allowing its incorporation into various formulations.
Neosorb 70/70 B is known for its stability and long shelf life under proper storage conditions.

Neosorb 70/70 B is a versatile ingredient, utilized in various industries, including pharmaceuticals, food, and personal care products.
Neosorb 70/70 B offers the advantage of being sugar-free and does not induce dental caries, making it tooth-friendly.

Due to its low caloric content, Neosorb 70/70 B is considered beneficial for individuals seeking reduced-calorie dietary options.
Neosorb 70/70 B has a low glycemic index, making it a suitable sweetener for people with diabetes or those concerned about blood sugar levels.
In the food industry, Neosorb 70/70 B is used in various applications, such as confectionery, bakery, and beverages, to provide sweetness and texture enhancement.

Neosorb 70/70 B's non-crystallizing nature ensures stable formulations, avoiding the risk of recrystallization during storage.
Neosorb 70/70 B can serve as an alternative to sucrose, providing similar taste and sweetness without the same caloric impact.
Its ability to retain moisture makes it valuable for maintaining the quality and appearance of certain cosmetic and personal care products.

Neosorb 70/70 B is considered a safe and well-tolerated ingredient for use in different consumer products.
The liquid sorbitol form of Neosorb 70/70 B allows for easy dosing and precise measurements in formulations.

As a plasticizer in soft gelatin capsules, it improves capsule elasticity, making them easier to swallow and digest.
Neosorb 70/70 B can contribute to the overall texture and mouthfeel of various products, enhancing consumer acceptance and enjoyment.
Neosorb 70/70 B's broad range of applications and favorable properties make Neosorb 70/70 B a valuable ingredient for creating innovative, sugar-free, and health-conscious products.



PROPERTIES


Chemical Name: Neosorb 70/70 B
Chemical Formula: C6H14O6
Molecular Weight: 182.2 g/mol


Physical Properties:

Appearance: Clear, viscous liquid
Color: Colorless to slightly yellow
Odor: Odorless
Taste: Sweet
Solubility: Highly soluble in water
Density: Approximately 1.29 g/cm³ at 20°C
Refractive Index: 1.455 - 1.465 at 20°C
Boiling Point: Approximately 230°C (decomposition starts above 160°C)
Melting Point: Approximately 95°C - 105°C (decomposition)
Flash Point: Not applicable (liquid)
Vapor Pressure: Negligible
Viscosity: High viscosity


Chemical Properties:

Chemical Stability: Stable under normal storage and handling conditions.
pH: Approximately 5.0 - 7.5 in a 10% aqueous solution at 20°C.
Hydrolysis: Hydrolyzes to sorbitol in the presence of water and acid or base.
Reducing Properties: Exhibits reducing properties due to the presence of aldehyde and ketone functional groups.
Reactivity: Generally unreactive under normal conditions; non-reactive with many common chemicals.
Combustibility: Non-flammable (liquid).



FIRST AID


Inhalation:
If inhaled, move the person to fresh air immediately.
If breathing is difficult, provide oxygen if available and seek medical attention promptly.

Skin Contact:
In case of skin contact, remove contaminated clothing and rinse the affected area with plenty of water.
Wash skin thoroughly with soap and water.
If irritation or redness persists, seek medical attention.

Eye Contact:
In case of eye contact, immediately flush the eyes with plenty of water for at least 15 minutes while holding the eyelids open.
Remove contact lenses, if present and easy to do, after rinsing.
Seek medical attention if eye irritation or redness persists.

Ingestion:
If swallowed, do not induce vomiting unless instructed to do so by medical personnel.
Rinse the mouth thoroughly with water if the person is conscious and can swallow.
Do not give anything by mouth to an unconscious person.
Seek medical attention immediately.



HANDLING AND STORAGE


Handling:

Use appropriate personal protective equipment (PPE) when handling Neosorb 70/70 B, including safety glasses, gloves, and protective clothing, to minimize skin and eye contact.
Avoid inhalation of vapors or mists. Work in a well-ventilated area, and use local exhaust ventilation, if available.
Prevent contact with eyes and skin. In case of accidental contact, rinse immediately with plenty of water.
Do not eat, drink, or smoke while handling Neosorb 70/70 B, and wash hands thoroughly after use.
Avoid generating dust or aerosols. Use caution during handling to minimize the potential for exposure.
Do not use compressed air for transfer or handling, as it may cause dust formation.


Storage:

Store Neosorb 70/70 B in a cool, dry, and well-ventilated area, away from sources of heat, sparks, and open flames.
Keep containers tightly closed and upright when not in use to prevent leakage or spillage.
Store away from strong oxidizing agents and incompatible substances.
Protect Neosorb 70/70 B from direct sunlight and exposure to excessive heat.
Store the chemical separately from food, beverages, and animal feed to avoid contamination.
Ensure that storage areas are equipped with appropriate containment measures to contain spills or leaks.


Storage Temperature:

Recommended storage temperature for Neosorb 70/70 B is ambient room temperature, typically between 20°C to 25°C (68°F to 77°F).
Avoid exposing the chemical to temperatures above 30°C (86°F) for extended periods, as it may lead to degradation or other undesirable changes.


Packaging:

Neosorb 70/70 B is commonly available in various packaging options, including drums, intermediate bulk containers (IBCs), and smaller containers like bottles or jugs.
Ensure that packaging materials are compatible with the chemical to prevent leakage or degradation.


Shelf Life:

The shelf life of Neosorb 70/70 B may vary based on storage conditions and the specific formulation, but it is generally stable for extended periods under proper storage conditions.
It is advisable to follow the manufacturer's recommendations and conduct periodic quality checks to ensure product integrity.


Handling Precautions:

Avoid rough handling or dropping containers to prevent breakage and spills.
Use appropriate material handling equipment to transport and transfer Neosorb 70/70 B to minimize the risk of exposure and contamination.


Storage Precautions:

Store Neosorb 70/70 B away from sources of ignition and potential fire hazards.
Keep the storage area clean and well-organized to avoid accidental mixing with incompatible substances.
Regularly inspect containers and storage areas for signs of damage or deterioration.



SYNONYMS


D-sorbitol
D-glucitol
Sorbitol solution
Sorbol
L-Gulitol
L-Gulose
L-Sorbose
Sorbit
Glucitol solution
Sorbitol liquid
Sorbitol syrup
Sorbitol USP
Sorbitol NF
Sorbitol BP
Sorbitol EP
Sorbitol FCC
Sorbitol GRAS
Sorbitol E420
Sorbitol E number E420
Sorbitol sweetener
Sorbitol humectant
Sorbitol plasticizer
Sorbitol bulking agent
Sorbitol sugar substitute
Sorbitol 70% solution
Sorbitol liquid 70%
Sorbitol 70% NF
Sorbitol 70% USP
Sorbitol 70% BP
Sorbitol 70% EP
Sorbitol 70% FCC
Sorbitol 70% GRAS
Sorbitol 70% E420
Sorbitol 70% E number E420
Sorbitol 70% sweetener
Sorbitol 70% humectant
Sorbitol 70% plasticizer
Sorbitol 70% bulking agent
Sorbitol 70% sugar substitute
Sorbitol syrup 70%
D-sorbitol 70%
D-glucitol 70%
Sorbitol aqueous solution
Sorbitol syrup NF
Sorbitol syrup USP
Sorbitol syrup BP
Sorbitol syrup EP
Sorbitol syrup FCC
Sorbitol syrup GRAS
Sorbitol solution 70%
Sorbitol liquid 70% solution
Sorbitol 70% w/v
Sorbitol 70% weight/volume
Sorbitol 70% in water
Sorbitol aqueous 70%
Sorbitol 70% syrup
Sorbitol syrup 70% w/v
Sorbitol 70% aqueous solution
Sorbitol 70% solution in water
Sorbitol liquid 70% w/v
Sorbitol 70% in water (v/v)
Sorbitol 70% solution in water (v/v)
Sorbitol 70% in water (w/w)
Sorbitol 70% solution in water (w/w)
Sorbitol 70% in aqueous medium
Sorbitol 70% in aqueous solution
Sorbitol 70% liquid preparation

MEA; N-ETHYLMETHYLAMINE; N-METHYLETHYLAMINE; (CH3)(C2H5)NH; Ethylamine, N-methyl-; Ethylmethylamine; ethyl-methyl-amine; Methylaminoethane; Methylethylamine; N-Ethyl-N-methylamine; n-methyl-ethanamin; N-methylethanamine; N-Methyl-ethanamine; N-Methyl-N-ethylamine; N-ETHYLMETHYLAMINE 98+%; N-ETHYLMETHYLAMINE OR N-METHYLETHYLAMINE; N-ETHYLMETHYLAMINE, 40% IN TOLUENE; 2-MAE; 2-Methylaminoethane; α,N-Dimethylmethanamine CAS NO:624-78-2

3-Azahexane;Ethylpropylamine;Propylethylamine;Einecs 243-573-4;N-Ethylpropylamin;ethyl-propyl-amine;N-ETHYLPROPYLAMINE;N-Ethylpropanamine;n-ethyl-1-propanamin;N,N-Ethylpropylamine CAS No.20193-20-8

1-Ethyl-2-pyrrolidinone; NEP; 1-éthylpyrrolidine-2-one; 1-Ethylpyrrolidin-2-one; 1-Ethylpyrrolidin-2-on; 1-Etilpirrolidin-2-ona; N-Ethylpyrrolidone; N-Ethyl-2-pyrrolidinon; N-Ethylpyrrolidinone; cas no:2687-91-4

1-Ethyl-2-pyrrolidinone; NEP; 1-éthylpyrrolidine-2-one; 1-Ethylpyrrolidin-2-one; 1-Ethylpyrrolidin-2-on; 1-Etilpirrolidin-2-ona; N-Ethylpyrrolidone; N-Ethyl-2-pyrrolidinon; N-Ethylpyrrolidinone; cas no :2687-91-4

1-Ethyl-2-pyrrolidinone; NEP; 1-éthylpyrrolidine-2-one; 1-Ethylpyrrolidin-2-one; 1-Ethylpyrrolidin-2-on; 1-Etilpirrolidin-2-ona; N-Ethylpyrrolidone; N-Ethyl-2-pyrrolidinon; N-Ethylpyrrolidinone; cas no:2687-91-4

SYNONYMS Morpholine, 4-ethyl-; 4-Ethylmorpholine; CAS NO:100-74-3

SYNONYMS Morpholine, 4-ethyl-; 4-Ethylmorpholine; N-Ethylmorpholine CAS NO:100-74-3

N-Ethyl-n-butylamine Ethylbutylamine N-ethylbutan-1-amine N-Ethylbutylamine 1-Butanamine, N-ethyl- N-Butylethylamine Ethyl-n-butylamine Butyl(ethyl)amine Butylamine, N-ethyl- BUTYLETHYLAMINE N-Ethylbutanamine N-Butyl-N-ethylamine N-n-Butylethylamine butyl-ethyl-amine ethyl-butyl amine N-butyl-ethylamine N-ethyl-n-butyl-amine N-n-butyl-N-ethylamine N-Ethyl-normal-butylamine cas :13360-63-9

1-Bromobutane; 1-Butyl bromide; cas no : 109-65-9

N-HEXYL GLYCOL; Ethylene glycol mono-n-hexyl ether, 2-hexoxy-1-ethanol cas no: 112-25-4

Neutrol TE is colorless viscous liquid.
Neutrol TE is gentle, non-irritating and non-greasy pH adjuster.
Neutrol TE is formulated with the feature high alcohol compatibility to stimulate a pleasant, nonsticky sensation on the skin.


CAS Number: 102-60-3
EC Number: 203-041-4
MDL number: MFCD00004534
Linear Formula: [CH3CH(OH)CH2]2NCH2CH2N[CH2CH(OH)CH3]2
Chemical Formula: C14H32N2O4
INCI Name: Tetrahydroxypropyl Ethylenediamine


Neutrol TE is miscible with water, methanol, ethanol, toluene, ethylene glycol and perchloroethylene.
Neutrol TE is incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents and chloroformates.
Neutrol TE is an ideal neutralizing agent for gel formulations such as carbomer.


Neutrol TE forms very few nitrosamines when compared to other amine-containing bases.
Neutrol TE is colorless liquid.
Neutrol TE is colorless viscous liquid.


Neutrol TE exhibits high alcohol compatibility and gives the skin a non-sticky and comfortable feel.
Neutrol TE forms very few nitrosamines when compared to other amine-containing bases.
Neutrol TE is a reaction product of ethylenediamine with 4 moles of propylene oxide.


Neutrol TE is formulated with the feature high alcohol compatibility to stimulate a pleasant, nonsticky sensation on the skin.
Neutrol TE is a reaction product of ethylenediamine with 4 moles of propylene oxide.
This gel, Neutrol TE, is formulated with the feature high alcohol compatibility to stimulate a pleasant, nonsticky sensation on the skin.


At room temperature, Neutrol TE is clear soluble in water, alcohol, and propylene glycol.
Neutrol TE forms dull dispersions in mineral oils.
It has been demonstrated that the tendency of Neutrol TE to form nitrosamines is extremely slight if it is substituted for other bases that contain amines.


Neutrol TE is a derivative of Ethylenediamine here all hydrogens connected with nitrogens are replaced with four 2-hydroxypropyl groups.
Neutrol TE is particularly suited as a neutralizing agent for polymers in clear gel formulations and forms clear solutions with solvents like water, ethanol, isopropanol, and propylene glycol.


The gels formulated with Neutrol TE have excellent alcohol compatibility and have a pleasant non-tacky skin feeling.
In comparison to other bases containing amines, it could be proved that Neutrol TE shows a considerably lower tendency to form nitroamines.
Neutrol TE has been toxicologically tested with regard to cosmetic use.


Within the recommended applications and concentrations of Neutrol TE, no indications of toxicological risks were found.
Neutrol TE is gentle, non-irritating and non-greasy pH adjuster.
Neutrol TE is a substituted amine.


Neutrol TE is excellent antistatic, dispersing, anticorrosive, lubricating, cleansing, emulsifying, solubilizing abilities.
Neutrol TE is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 tonnes per annum.
Neutrol TE is biodegradable.


Neutrol TE is easily soluble in water, and the aqueous solution is weakly alkaline.
Neutrol TE is excellent antistatic, dispersing, anticorrosive, lubricating, cleansing, emulsifying, solubilizing abilities.
Neutrol TE is a chelating agent that binds with metal ions or metallic compounds, preventing them from adhering to a surface (such as skin, hair, or clothing) or causing contamination, such as in the case of trace amounts of iron.




USES and APPLICATIONS of NEUTROL TE:
Neutrol TE uses and applications include: Detergent polymer; for surface coatings; emulsions; paints; paper and leather finishes; water treatment; dispersant and scale inhibitor for oil field water treatment; binder for textiles; thickener for fabric laminates, textile printing pastes; antistat, binder, film-former in cosmetics; thickener, stabilizer for cosmetics, paints, inks, waxes, polishes, detergents, etc.; in food packaging adhesives; in paperpaperboard in contact with dry food.


Neutrol TE is a Polymers of two or more monomers consisting of acrylic acid, methacrylic acid, or their simple esters.
Neutrol TE is used Cosmetic, Water Treatment, Textiles, Adhesives, Detergent.
Neutrol TE is used as a catalyst in the production of urethane foams.


Neutrol TE acts as a complexing agent, plasticizer, surfactant solubilizer and curing agent for epoxy resin.
Neutrol TE is also used as a viscosity modifier and as an anti-bloating agent for cattle.
Neutrol TE is utilized in piezoelectric crystal detectors of sulfur dioxide and in additives for paint.


Neutrol TE serves as a biological buffer as well as reagent for manganese.
Further, Neutrol TE finds application in adhesives and sealant chemicals.
In addition to this, Neutrol TE is used as a cross-linking agent.


Neutrol TE is used as a catalyst in manufacturing urethane foams, epoxy resin curing agent, complexing agent, humectant, plasticizer, chelate, surfactant solubilizer, viscosity modifier, and intermediate.
Neutrol TE is also used as an anti-bloating agent for cattle.


Neutrol TE is used in piezoelectric crystal detectors
Neutrol TE is the most suitable neutralizing agent for gel formulations using carbomer, etc.
Neutrol TE is used for Face care, Body care, Make-up, Face and body hygiene, Hair care.


Neutrol TE is also used by the cosmetic industry in soap-making and in stearate creams.
Neutrol TE is used Antiperspirant/Deodorants, Body Care, Oral Care, Sun Care, and more.
These high-performing products enable the development of formulations that fulfill consumer’s needs.


Gels formulated with Neutrol TE feature high alcohol compatibility and stimulate a pleasant, non-sticky sensation on the skin.
Other applications for Neutrol TE in the cosmetic field are the manufacture of soap, the production of stearate cremes, and the neutralization of sunscreens that contain acid groups.


Neutrol TE is a neutralizing agent for carbomer resins.
Neutrol TE is used in the production of gels.
Neutrol TE finds application in formulating skin-, sun-, men-, mother- & baby-, body-, face and color care products.


Neutrol TE is also used in skin cleansing, hair care (hair coloring, shampoos, conditioners, styling products), self-tanning, liquid soaps and shower/bath products.
Neutrol TE is used neutralizing agent for carbomer resins, e.g. in the production of gels.


Neutrol TE is an eminently suitable neutralizing agent for carbomer resin.
For example: in the production of gels.
Neutrol TE is used Bath & Shower, Body Care, Eye Liner, Face Care, Foundations, Mascara, Skin Care, Skin Cleansing, Sun Care.


Neutrol TE is a neutralizing agent that is used for carbomer resins (e.g., in the production of gels).
Neutrol TE is a clear, viscous liquid that is commonly used in baby care and cleansing, body care, face cleansing, hair coloring, shower/bath products, styling, etc.


Neutrol TE is used for the manufacture of soap and stearate cremes.
Neutrol TE is used Skin Care, Cleanser, Sun Care, Mother and baby, Hair care, Shampoo and Conditioner, Styling product, Hair color, Bath and Body
Men, Skin care, Body care, Face Care, Self Tanning, Pet Care, Pet Care TSCA, and Pet Care DSL.


Neutrol TE is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Neutrol TE is used in the following products: coating products, adhesives and sealants, washing & cleaning products and cosmetics and personal care products.


Other release to the environment of Neutrol TE is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Neutrol TE is used in the following areas: agriculture, forestry and fishing.


Release to the environment of Neutrol TE can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release.


Neutrol TE is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).


Neutrol TE can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and electrical batteries and accumulators.
Neutrol TE is used in the following products: coating products, adhesives and sealants and polymers.


Neutrol TE can be found in products with material based on: plastic used for toys and other articles intended for children’s use, including baby-bottles, plastic used for articles with intense direct dermal (skin) contact during normal use (e.g. handles, ball pens), plastic (e.g. food packaging and storage, toys, mobile phones) and wood (e.g. floors, furniture, toys).


Neutrol TE is used for the manufacture of: chemicals and plastic products.
Other release to the environment of Neutrol TE is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).


Neutrol TE is used in the following products: coating products, adhesives and sealants, adsorbents, air care products, anti-freeze products, metals, biocides (e.g. disinfectants, pest control products), fillers, putties, plasters, modelling clay and non-metal-surface treatment products.
Release to the environment of Neutrol TE can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles.


Neutrol TE is used in the following products: polymers and adhesives and sealants.
Neutrol TE is used in the following areas: formulation of mixtures and/or re-packaging.
Neutrol TE is used for the manufacture of: chemicals.


Release to the environment of Neutrol TE can occur from industrial use: for thermoplastic manufacture, in the production of articles, formulation of mixtures, formulation in materials and in processing aids at industrial sites.
Release to the environment of Neutrol TE can occur from industrial use: manufacturing of the substance, formulation of mixtures, and thermoplastic manufacture.


Neutrol TE is used metal complexing agent for electroless copper plating in circuit board manufacturing.
Neutrol TE is used crosslinking agent for polyurethane products.
Neutrol TE is used concrete water reducing agent raw materials.


Neutrol TE is used for a flux and cleaning agent.
Neutrol TE is used for synthetic rubber, antistatic agent, synthetic plastic stabilizer.
Neutrol TE is used as metal complexing agent, as scaling powder and cleaner in electroless copper PCB plating.


Neutrol TE is used as metal complexing agent, used as scaling powder and cleaner in electroless copper PCB plating.
Neutrol TE is a chelant and it is used in cosmetics to bind metal ions to prevent unwanted metal-reactions within the formulation which could have negative effects on stability, preservation and product performance.


In Colorants Neutrol TE helps to preserve the intended color result and product stability in case of metal ion exposure during manufacturing of the tint.
Neutrol TE is mainly used for electroless copper plating complexing agent.
Neutrol TE is used Chelating agent, solvent.


Neutrol TE is used for electroless copper plating in circuit board manufacturing.
Neutrol TE is mainly used for chemical copper plating complexing agent.
Metal complexing agent, Neutrol TE is used for electroless copper plating, flux and cleaning agent in circuit board manufacturing.


Neutrol TE is used as solvent.
Neutrol TE is used as cleansing agent.
Neutrol TE is used as emulsifying agent, dispersing agent.


Neutrol TE is used as corrosion inhibitor, lubricant.
Neutrol TE is used as antistatic agent.
Neutrol TE is used as chelating agent.


Neutrol TE is used as intermediate in organic synthesis.
Neutrol TE is used Chelating agent in personal care products
Neutrol TE is a complexing agent.
Cosmetic Uses of Neutrol TE: chelating agents



BENEFITS CLAIMS OF NEUTROL TE:
*Chelating
*Sun Protection
*Cleansing
*Self-Tanning
*Non-Irradiated
*Ease of Styling
*After-Sun Repair



FUNCTIONS OF NEUTROL TE:
*Scale Inhibitor
*Acid
*Dispersant
*Stabilizer
*pH adjuster / buffer
*Neutralizing Agent



ALTERNATIVE PARENTS OF NEUTROL TE:
*Trialkylamines
*Secondary alcohols
*Organopnictogen compounds
*Hydrocarbon derivatives



SUBSTITUENTS OF NEUTROL TE:
*Tertiary aliphatic amine
*Tertiary amine
*Secondary alcohol
*1,2-aminoalcohol
*Organic oxygen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organooxygen compound
*Alcohol
*Aliphatic acyclic compound



WHAT DOES NEUTROL TE DO IN A FORMULATION?
*Chelating



FUNCTIONS OF NEUTROL TE:
*Chelating agent:
Neutrol TE reacts and forms complexes with metal ions which could affect the stability and/or appearance of cosmetic products



PHYSICAL and CHEMICAL PROPERTIES of NEUTROL TE:
Physical state: viscous
Color: colorless
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: 175 - 181 °C at 1 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 211 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility soluble
Partition coefficient: n-octanol/water
log Pow: -2,08 at 25 °C
Vapor pressure: 0,000011 hPa at 20 °C
Density: 1,013 g/mL at 25 °C

Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Surface tension: 63,94 mN/m at 20 °C
Water Solubility: 79.4 g/L
logP: -0.66, logP: -0.89, logS: -0.57
pKa (Strongest Acidic): 14.69
pKa (Strongest Basic): 9.5
Physiological Charge: 1
Hydrogen Acceptor Count: 6
Hydrogen Donor Count: 4
Polar Surface Area: 87.4 Ų
Rotatable Bond Count: 11
Refractivity: 80.85 m³·mol⁻¹

Polarizability: 33.93 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule
Density: 1.03
Boiling Point: 240°C (10mmHg)
Flash Point: >110°C (230°F)
Odor: Odorless
Refractive Index: 1.48
Merck Index: 14,3599
Solubility Information: Miscible with water,methanol,ethanol,toluene,ethylene glycol and perchloroethylene.
Formula Weight: 292.42
Percent Purity: 99%
Chemical Name or Material: N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Molecular Weight: 292.41 g/mol

XLogP3-AA: -0.7
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 11
Exact Mass: 292.23620751 g/mol
Monoisotopic Mass: 292.23620751 g/mol
Topological Polar Surface Area: 87.4Ų
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 199
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 4
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 1e+006 mg/L @ 25 °C (est)
Formula: C14h32n2o4
CAS No.: 102-60-3
EINECS: 203-041-4
Status: Liquid Catalyst
Response Type: Polymerization
Classification: Homogeneous Catalysts
Effect Size: Neutrol TE
Application: Industry
Appearance: Colorless to light yellow clear liquid
Assay: 99%min.
Appearance: Colorless to light yellow clear liquid
Assay: 99%min
Content of water: ≤0.15
pH value: 8.0-11.0
Solubility: Clear liquid
Melting point: 32°C
Boiling point: 175-181 °C0.8 mm Hg(lit.)
Density: 1.03 g/mL at 20 °C(lit.)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.4812(lit.)
Fp: >230 °F
Storage temp.: Store below 30°C.
PKA: 14.23±0.20(Predicted)
Specific Gravity: 1.013
PH: 10.4 (10g/l, H2O, 20℃)
Appearance: Colorless to light yellow viscous liquid
Colorless viscous liquid
PH Value, 1% water solution: 10.0 ~12.0
Effective content (%): 73.0 ~ 77.0
Color (Pt-Co): ≤ 30
Dynamic viscocity: (mPa’s, 25℃） 205 ~ 360
Proportion (g/cm3, 25℃）: 1.040 ~ 1.060
Solubility: 100% soluble in water



FIRST AID MEASURES of NEUTROL TE:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NEUTROL TE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.




FIRE FIGHTING MEASURES of NEUTROL TE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEUTROL TE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Safety glasses with side-shields.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 120 min
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEUTROL TE:
-Precautions for safe handling:
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.



STABILITY and REACTIVITY of NEUTROL TE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
Edetol, Entprol, (Ethylenedinitrilo)tetra-2-propanol, Quadrol
102-60-3
203-041-4
1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL)
2-PROPANOL, 1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS-
EDETOL [HSDB]
EDETOL [INN]
EDETOL [USAN]
ENTPROL [MI]
N,N,N',N'-TETRAKIS (2-HYDROXYPROPYL) ETHYLENEDIAMINE
N,N,N',N'-TETRAKIS(2-HYDROXYPROPYL)ETHYLENEDIAMINE
NEUTROL TE
NSC-369219
QUADROL
TETRAHYDROXYPROPYL ETHYLENEDIAMINE
TETRAHYDROXYPROPYL ETHYLENEDIAMINE [INCI]
Quadrol
Edetol
Entprol
Neutrol TE
Quadrol
THPE
(Ethylenedinitrilo)tetra-2-propanol
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
1-({2-[Bis(2-hydroxypropyl)amino]ethyl}(2-hydroxypropyl)amino)propan-2-ol
1-{2-[Bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino}-2-propanol
1-{2-[Bis(2-oxidanylpropyl)amino]ethyl-(2-oxidanylpropyl)amino}propan-2-ol
Tetrahydroxypropyl ethylenediamine
Tetrahydroxypropyl ethylenediamine
Tetrakis(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-(Ethylenedinitrilo)tetra-2-propanol
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
1,1',1',1'''-(Ethylenedinitrilo)tetra-2-propanol
2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-
2-Propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-
Adeka Quadrol
ENTPROL
Entprol
N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Neutrol TE
Quadrol
Quadrol L
THPE
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol monotosylate
Quadrol
N,N,N',n'-tetrakis(2-hydroxypropyl)ethylenediamine
Tetrahydroxypropyl ethylenediamine
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol
2-Propanol,1,1',1'',1'''-(ethylenedinitrilo)tetra- (6CI,7CI,8CI)
1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetrakis[2-propanol]
1,1',1'',1'''-(Ethylenedinitrilo)tetra(2-propanol)
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
Adeka Quadrol
ENTPROL
EPD 300
Edetol
Laprol 294
N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
N,N,N',N'-Tetrakis(b-hydroxypropyl)ethylenediamine
NP 300
NSC 369219
Neutrol
Neutrol TE
Newpol NP 300
Quadrol
Quadrol L
THPE
Tetrakis(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL)
2-PROPANOL, 1,1',1'',1'''-(1,2- ETHANEDIYLDINITRILO)TETRAKIS-
EDETOL
EDETOL [HSDB]
EDETOL [INN]
EDETOL [USAN]
ENTPROL [MI]
N,N,N',N'-TETRAKIS (2-HYDROXYPROPYL) ETHYLENEDIAMINE
N,N,N',N'-TETRAKIS( 2-HYDROXYPROPYL)ETHYLENEDIAMINE
NEUTROL TE
NSC-369219
QUADROL
TETRAHYDROXYPROPYL ETHYLENEDIAMINE
TETRAHYDROXYPROPYL ETHYLENEDIAMINE [INCI]
102-60-3
Edetol
Quadrol
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Entprol
Neutrol TE
Adeka Quadrol
Quadrol L
1,1',1'',1'''-(Ethylenedinitrilo)tetra-2-propanol
Tetrahydroxypropyl ethylenediamine
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
Edetolum [Latin]
1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol)
Edetol [USAN:INN]
Edetolum
NSC 369219
EDTP
N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-Ethylenedinitrilotetrapropan-2-ol
HSDB 5349
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
TETRAKIS(2-HYDROXYPROPYL)ETHYLENEDIAMINE
EINECS 203-041-4
NSC-369219
BRN 1781143
UNII-Q4R969U9FR
2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-
CCRIS 8275
Q4R969U9FR
DTXSID9026689
Ethylenediamine-N,N,N',N'-tetra-2-propanol
2-Propanol, 1',1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
C14H32N2O4
Edetol (USAN)
1,1',1'',1'''-(Ethanediylnitrilo)tetrakis(2-propanol)
NCGC00164339-02
EDETOL [USAN]
EC 203-041-4
4-04-00-01685 (Beilstein Handbook Reference)
1,1',1',1'''-(Ethylenedinitrilo)tetra-2-propanol
DTXCID806689
Ethylenedinitrilotetra-2-Propanol
N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine, 98%
2-Propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-
CAS-102-60-3
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
EDTP
1,1',1'',1'''-(ethane-1,2-diyldinitrilo)tetrapropan-2-ol
Quadrol(R)
(Ethylenedinitrilo)tetra-2-propanol
Neutrol TE (TN)
EDETOL [HSDB]
EDETOL [INN]
ENTPROL [MI]
SCHEMBL48412
MLS004773924
N,N,N,N-Tetrakis(2-Hydroxypropyl)- Ethylenediamine
CHEMBL1573178
CHEBI:193592
HMS3264C08
Pharmakon1600-01301023
HY-B2149
Tox21_112102
Tox21_201973
Tox21_300552
MFCD00004534
NSC369219
NSC760394
tetra(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))-tetrakis(propan-2-ol)
AKOS015892820
C14-H32-N2-O4
Tox21_112102_1
CCG-230630
NSC-760394
SB82446
Tetra (2-hydroxypropyl) ethylenediamine
NCGC00164339-01
NCGC00164339-03
NCGC00164339-04
NCGC00164339-05
NCGC00254289-01
NCGC00259522-01
BS-23689
SMR001600027
LS-122312
CS-0020301
FT-0626306
T0781
D03948
F71260
N(CCN(CC(C)O)CC(C)O)(CC(C)O)CC(C)O
NNN'N'-Tetrakis(2-Hydroxypropyl)ethylenediamine
TETRAHYDROXYPROPYL ETHYLENEDIAMINE [INCI]
Tetrakis-[N-(2-hydroxy-propyl)]-ethylenediamine
1,1',1'',1'''-ethylendinitrilotetrapropan-2-ol
A800588
J-000740
n,n,n',n'-tetrakis (2-hydroxypropyl) ethylenediamine
N,N,N',N'-tetrakis-(2-hydroxypropyl)ethylenediamine
N,N,N,N-Tetrakis(2-hydroxypropyl)ethylenediamine;EDTP
Q26841009
Ethylenedinitrilo)tetra-2-propanol, 1,1',1'',1'''-(
1, 1', 1'', 1'''- ethylenedinitrilotetrapropan- 2- ol
2-Propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis-
1,1',1'',1'''-(ethane-1,2-diylbis(azanetriyl))tetrapropan-2-ol
1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL)
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]-2-propanol
1-[2-[bis(2-oxidanylpropyl)amino]ethyl-(2-oxidanylpropyl)amino]propan-2-ol
2-propanol, 1,1', 1'', 1'''-(1,2-etanodiildinitrilo) tetraquis-
1,1'',1'''',1''''''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol)
N,N,N inverted exclamation marka,N inverted exclamation marka-Tetrakis(2-hydroxypropyl)ethylenediamine
Edetol [USAN:INN]; 1,1,1,1-(Ethylenedinitrilo)tetra-2-propanol
Entprol
Tetrakis(2-hydroxypropyl)ethylenediamine
2-Propanol, 1,1,1,1-(1,2-ethanediyldinitrilo)tetrakis-
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
THPE
Chemical Q75
EDTP Neutrol TE
Edetol [USAN:INN]; 1,1,1,1-(Ethylenedinitrilo)tetra-2-propanol
Entprol
Tetrakis(2-hydroxypropyl)ethylenediamine
2-Propanol, 1,1,1,1-(1,2-ethanediyldinitrilo)tetrakis-
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
THPE
Chemical Q75
EDTP Neutrol TE

N-Hance BF-13 Cationic Guar is a yellow or white powdered ingredient that is obtained from guar beans.
N-Hance BF-13 Cationic Guar is a quaternary polymer that provides the dual benefits of conditioning and viscosity build.
N-Hance BF-13 Cationic Guar is substantive to anionic surfaces such as skin and hair.

CAS Number: 65497-29-2
Molecular Formula: C6H16NO2.xCl.xUnspecified

Guar hydroxypropyl trimonium chloride,65497-29-2, Guar hydroxypropyl trimethyl ammonium chloride,Cationic Guar Gum,Guar Hydroxypropyltrimnonium Chlide,gumguar2-hydroxy-3-(trimethylammonio)-propylet,jaguarc13s,GUM GUAR 2-HYDROXY-3-(TRIMETHYLAMMONIO)&,cosmediaguarc261,Guar,2-hydroxy-3-trimethylammoniopropylether,chloride.

N-Hance BF-13 Cationic Guar is boron-free which differentiates it from typical cationic guars.
N-Hance BF-13 Cationic Guar is generally used in shampoos and other hair products where it acts as a conditioner and an anti-static agent.
N-Hance BF-13 Cationic Guar is also used in skin care products where it deeply conditions the skin.

The chemical formula of Guar hydroxypropyltrimonium chloride is C6H16NO2.
Further, N-Hance BF-13 Cationic Guar is used as a substitute for harsh silicones.
N-Hance BF-13 Cationic Guar acts as a film-forming agent: It forms a thin layer of film over the skin, hair and prevents them from the harmful effects of environmental aggressors.

N-Hance BF-13 Cationic Guar also helps in trapping moisture in the skin and hair and prevents the moisture from escaping, thus hydrating the skin and hair which makes them softer and smoother.
N-Hance BF-13 Cationic Guar by Ashland acts as a thickener and conditioning agent.
This quaternary polymer is a medium-cationic-substitution, high-molecular-weight polymer.

N-Hance BF-13 Cationic Guar is boron-free which differentiates it from typical cationic guars.
N-Hance BF-13 Cationic Guar is substantive to anionic surfaces such as skin and hair.
Upon dilution of the surfactants with water, the cationic guar will complex with the anionic surfactants.

The complex will deposit cosmetically effective levels of ingredients such as silicone or emollient oils onto hair and skin.
N-Hance BF-13 Cationic Guar is designed for use in shampoos and body washes.
N-Hance BF-13 Cationic Guar, commonly known as guar gum or guar conditioner, is a quaternary ammonium derivative of guar gum.

N-Hance BF-13 Cationic Guar itself is a natural substance derived from guar beans and is often used in various industries, including food, cosmetics, and personal care products.
N-Hance BF-13 Cationic Guar acts as an antistatic agent: It neutralizes the electrons generated through static electricity.
This helps in the easy combing of hair when wet and prevents the formation of knots.

N-Hance BF-13 Cationic Guar acts as a skin-conditioning agent: It makes the skin softer and smoother.
N-Hance BF-13 Cationic Guar absorbs moisture which keeps the skin hydrated and makes the skin cleaner.
By conditioning the skin N-Hance BF-13 Cationic Guar makes the skin look younger.

N-Hance BF-13 Cationic Guars are cationic polymers that provide the dual benefits of conditioning and thickening.
The cationic charge makes the product substantive to anionic surfaces such as skin and hair.
Many of the products in the N-Hance BF-13 Cationic Guar product line have a high molecular weight, water-soluble backbone and are effective viscosifiers in aqueous solutions and surfactant-based systems.

N-Hance BF-13 Cationic Guar acts as a viscosity controlling agent: N-Hance BF-13 Cationic Guar makes the product thicker and imparts a gel-like consistency to the products.
N-Hance BF-13 Cationic Guar is a hydroxypropylated cationic guar derivative that provides conditioning benefits.
The cationic charge of N-Hance BF-13 Cationic Guar interacts with keratin providing a conditioning effect on hair and skin and reducing the negative effects of soaps and surfactants.

N-Hance BF-13 Cationic Guar is also used in skin care products where it deeply conditions the skin.
The chemical formula of N-Hance BF-13 Cationic Guar is C6H16NO2.
Further, N-Hance BF-13 Cationic Guar is used as a substitute for harsh silicones.

The main function of N-Hance BF-13 Cationic Guar is to extend conditioning properties to hair care products.
N-Hance BF-13 Cationic Guar is also sometimes used in skin care products to achieve the same results.
N-Hance BF-13 Cationic Guar is a positively charged ingredient, that cancels the negative charge on hair causing it to have a static or become tangled.

This ingredient makes the hair silky smooth without weighing them down.
N-Hance BF-13 Cationic Guar nourishes the skin and also increases the viscosity of the formulations.
N-Hance BF-13 Cationic Guar is an organic compound that is a water-soluble quaternary ammonium derivative of guar gum.

N-Hance BF-13 Cationic Guar gives conditioning properties to shampoos and after-shampoo hair care products.
The effects of the cationic charge density, guar concentration in aqueous solution, and treatment time on bleached European hair have been studied.
A mechanical testing method has been successfully applied to determine the efficacy of cationic guars to improve the ease of combing.

The results were confirmed in a shampoo formulation on both virgin and bleached hair.
N-Hance BF-13 Cationic Guar is an organic compound.
N-Hance BF-13 Cationic Guar is a water-soluble quaternary ammonium derivative of guar gum.

N-Hance BF-13 Cationic Guar gives conditioning properties to shampoos and after-shampoo hair care products.
N-Hance BF-13 Cationic Guar is a white or yellow fine powder derived from guar beans.
N-Hance BF-13 Cationic Guar is a white or yellow fine powder derived from guar beans.

N-Hance BF-13 Cationic Guar is a kind of galactomannan, which is a polysaccharide.
The N-Hance BF-13 Cationic Guar comes from the guar plant, which is a legume.
Major world suppliers include India, Pakistan, and the United States, as well as Australia and Africa.

The plant’s bean has a large endosperm, which is the part of the seed that acts as a food store for the developing plant.
Much of that endosperm contains N-Hance BF-13 Cationic Guar, which forms a viscous gel called guar gum when mixed with cold water.
N-Hance BF-13 Cationic Guar is a kind of galactomannan, which is a polysaccharide.

N-Hance BF-13 Cationic Guar comes from the guar plant, which is a legume.
N-Hance BF-13 Cationic Guar is a water-soluble, organic compound that is a quaternary ammonium derivative of guar (aka cluster beans).
N-Hance BF-13 Cationic Guar is a substance whose chemical structure has four carbon groups attached to a positively charged nitrogen atom.

N-Hance BF-13 Cationic Guar is widely used in hair care products, such as shampoos and conditioners, as a conditioning agent.
N-Hance BF-13 Cationic Guar is cationic nature allows it to adhere to the hair shaft, providing a smooth and conditioned feel to the hair.

In addition to its conditioning properties, N-Hance BF-13 Cationic Guar acts as a thickening agent in cosmetic formulations.
N-Hance BF-13 Cationic Guar helps improve the viscosity of products, contributing to their texture and consistency.
The cationic nature of N-Hance BF-13 Cationic Guar helps in detangling hair, making it easier to comb and manage.

This is particularly beneficial in leave-in conditioners and hair styling products.
N-Hance BF-13 Cationic Guar helps reduce static electricity in the hair, contributing to a smoother and more manageable appearance.
N-Hance BF-13 Cationic Guar can also be found in certain skin care products, where it may contribute to the formulation's texture and provide conditioning benefits.

This N-Hance BF-13 Cationic Guar is often compatible with a wide range of cosmetic ingredients and formulations, making it a versatile choice for personal care product development.
N-Hance BF-13 Cationic Guar is a quaternary ammonium derivative of guar gum.
N-Hance BF-13 Cationic Guar is used in hair conditioning products.

Although a great conditioning agent for both skin and hair, N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
Because it is positively charged, or cationic, N-Hance BF-13 Cationic Guar neutralizes the negative charges on hair strands that cause hair to become static or tangled.
Better yet, N-Hance BF-13 Cationic Guar does this without weighing hair down.

N-Hance BF-13 Cationic Guar is often used as an anti-static agent and skin or hair conditioner; it also increases viscosity.
N-Hance BF-13 Cationic Guar is also found in hundreds of personal care products, such as shampoo, conditioner, dandruff treatments, styling products, soap, hairspray, and other products.
N-Hance BF-13 Cationic Guar is a yellow or white powdered ingredient that is obtained from guar beans.

N-Hance BF-13 Cationic Guar acts as a film-forming agent:
N-Hance BF-13 Cationic Guar forms a thin layer of film over the skin, hair and prevents them from the harmful effects of environmental aggressors.
N-Hance BF-13 Cationic Guar acts as a skin-conditioning agent: It makes the skin softer and smoother.

N-Hance BF-13 Cationic Guar is a water-soluble, organic compound that is a quaternary ammonium derivative of guar (aka cluster beans).
This means it is a N-Hance BF-13 Cationic Guar whose chemical structure has four carbon groups attached to a positively charged nitrogen atom.
While plant derived, there is a synthetic portion to it.

N-Hance BF-13 Cationic Guar acts as a viscosity controlling agent: N-Hance BF-13 Cationic Guar is also used in skin care products where it deeply conditions the skin.
N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
N-Hance BF-13 Cationic Guar is a cationic polymer that can provide both conditioning and thickening effects.

N-Hance BF-13 Cationic Guar is high degree of cationic substitution and large molecular weight allow the polymer to adsorb on anionic surfaces (e.g., skin, hair).
Applicable to: conditioning shampoo (providing good dry and wet combing performance to make hair refreshing and elegant); hand sanitizer, face wash and liquid soap (providing soft, smooth and moisturizing skin when dry and non-slippery when wet).
N-Hance BF-13 Cationic Guar is generally considered safe.

N-Hance BF-13 Cationic Guar can also be used in personal care products to thicken formulations and provide skinconditioning benefits.
N-Hance BF-13 Cationic Guar is a water-soluble ingredient that is derived from plant-based sources.
N-Hance BF-13 Cationic Guar is generally used in hair care products as it helps to reduce static while retaining volume.

N-Hance BF-13 Cationic Guar is most widely used in hair care products
N-Hance BF-13 Cationic Guar is an organic compound that is a water-soluble quaternary ammonium derivative of guar gum.

Melting point: >300 °C(lit.)
Density:1.3 g/mL at 25 °C(lit.)
Odor: at 100.00?%. odorless

N-Hance BF-13 Cationic Guar is a compound that is water soluble. Although a great conditioning agent for both hair and scalp, this compound most definitely gives the biggest benefits to your strands of hair.
The reason being is that N-Hance BF-13 Cationic Guar’s positively charged, also known as cationic.
This means that N-Hance BF-13 Cationic Guar neutralises the negative charges on hair strands that cause hair to become static or tangled.

The result, easier combing, reduced frizz and minimised flyaways.
N-Hance BF-13 Cationic Guar is also a lightweight ingredient as its often used in place of other anti-static ingredients that are heavier which weigh the hair down, which is especially an issue on finer hair.
Although N-Hance BF-13 Cationic Guar’s majority plant based, there is a synthetic portion to the ingredient.

N-Hance BF-13 Cationic Guars are harvested from the Guar Gum Bush.
This bush can be found in the likes of India and Pakistan,USA and even Australia and Africa.
N-Hance BF-13 Cationic Guar is identified as a white or yellow like powder.

N-Hance BF-13 Cationic Guar is a great conditioning agent for both skin and hair.
N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
N-Hance BF-13 Cationic Guar is generally considered safe.

N-Hance BF-13 Cationic Guar is a naturally derived cationic polymer that is commonly used as a conditioning agent in shampoos, cream rinse conditioners, shower gels, body washes, and skin cleanser formulas.
Derived from the N-Hance BF-13 Cationic Guar, the polymer's backbone is a Mannose-Galactose Polysaccharide that has been cauterized to enhance substantivity to hair and skin.
N-Hance BF-13 Cationic Guar is a yellow, free-flowing powder with a slight amine odor.

N-Hance BF-13 Cationic Guar is an organic compound that is a water-soluble quaternary ammonium derivative of guar gum.
N-Hance BF-13 Cationic Guar gives conditioning properties to shampoos and after-shampoo hair care products.
N-Hance BF-13 Cationic Guar is an organic compound with charged properties, derived from guar gum.

N-Hance BF-13 Cationic Guar is a domesticated legume crop, with most of of the world's production in India.
Cultivated plants grow to around 1 meter tall, with hairy stems and leaves.
The leaves, seed pods and seeds are all known to be edible, and are often cooked in curries.

Harvested seeds or 'guar beans' are dehusked, roasted, hydrated and ground to produce guar gum.
N-Hance BF-13 Cationic Guar has charged properties that make it especially useful in hair care formulations.
N-Hance BF-13 Cationic Guar is cationic (positively charged) and works by neutralizing the negative charges on hair strands that cause static and tangling.

N-Hance BF-13 Cationic Guar can also be used in personal care products to thicken formulations and provide skinconditioning benefits.
N-Hance BF-13 Cationic Guar is a conditioning ingredient that is used in both skincare and hair care products.
N-Hance BF-13 Cationic Guar is a chemical component found in cosmetic and personal care goods, particularly hair care products.

N-Hance BF-13 Cationic Guar is made from guar gum, a natural material obtained from the seeds of the guar plant.
N-Hance BF-13 Cationic Guar is generally used for conditioning and thickening.
N-Hance BF-13 Cationic Guar is a water-soluble ingredient that is derived from plant-based sources.

N-Hance BF-13 Cationic Guar is generally used in hair care products as it helps to reduce static while retaining volume.
N-Hance BF-13 Cationic Guar is a water-soluble ingredient that is derived from plant-based sources.
N-Hance BF-13 Cationic Guar is generally used in hair care products as it helps to reduce static while retaining volume.

N-Hance BF-13 Cationic Guar may sound like a mouthful, but it's a frequent ingredient in hair care and cosmetic products.
N-Hance BF-13 Cationic Guar should be noted that, like any other ingredient, some people may be sensitive to or allergic to N-Hance BF-13 Cationic Guar.
Always conduct a patch test before using a new product, and discontinue use if any adverse reactions occur.

N-Hance BF-13 Cationic Guar is a conditioning agent for both the skin and hair N-Hance BF-13 Cationic Guar helps to moisturize.
While N-Hance BF-13 Cationic Guar is sometimes used in skincare formulations it is more often used in hair care products.
N-Hance BF-13 Cationic Guar is most widely used in hair care products due to the added benefit of helping to reduce static between hair strands.

N-Hance BF-13 Cationic Guar is commonly used as a conditioning agent in shampoo formulations.
N-Hance BF-13 Cationic Guar forms a coacervate with anionic surfactants from the shampoo formulation upon dilution and deposits on the surface of hair providing conditioning in the form of reduced wet combing forces.
The dilution and deposition phenomenon occurs when the system is diluted below the critical micelle concentration of the shampoo surfactants, resulting in the formation of the insoluble coacervate.

The properties of the formed coacervate depend on a variety of characteristics of the polymer, including molecular weight and charge density, as well as the composition of surfactants and presence of electrolytes.
In addition, N-Hance BF-13 Cationic Guar has reported uses in liquid soap and body wash formulations, hair conditioners, hair styling products, and skin care preparations.

Uses:
N-Hance BF-13 Cationic Guar is an anti-irritant and anti-inflammatory that is also used as a thickening, conditioning, and anti-static agent.
N-Hance BF-13 Cationic Guar helps maintain a product’s smoothing action.
Some manufacturers cite it as also having skin-softening capabilities.

N-Hance BF-13 Cationic Guar imparts excellent skin conditioning in creams or lotions that otherwise may not be used on the face.
N-Hance BF-13 Cationic Guar adds lubricity to a product when in contact with the skin.
There is some evidence that it can enhance a formulation’s viscosity and stability.

N-Hance BF-13 Cationic Guar is a derivative of guar gum.
Although a great conditioning agent for both skin and hair, N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
Because it is positively charged, or cationic, it neutralizes the negative charges on hair strands that cause hair to become static or tangled.

Better yet, N-Hance BF-13 Cationic Guar does this without weighing hair down.
Typically used in formulations at 0.10% to 0.50% concentration levels, N-Hance BF-13 Cationic Guar is entirely compatible with most common anionic, cationic, and amphoteric surfactants and is ideally suited for use in two-in-one conditioning shampoos and moisturizing skin cleansing products.
When used in personal cleansing formulations, N-Hance BF-13 Cationic Guar imparts a soft, elegant after-feel to the skin.

Also, it enhances wet comb and dry comb properties in shampoos and hair conditioning systems.
Unlike similar ingredients, N-Hance BF-13 Cationic Guar is self-hydrating in water and does not require acidification during use.
N-Hance BF-13 Cationic Guar, one of the most widely used synthetic cationic polymers in the cosmetics industry, is an ingredient that’s often seen in conditioners and body washes.

N-Hance BF-13 Cationic Guar functions as a conditioning agent for skin and hair, helps deposit active ingredients on skin and/or hair, and also provides anti-static properties without weighing hair down.
N-Hance BF-13 Cationic Guar is a key ingredient in hair conditioners, providing a smooth and conditioned feel to the hair.
N-Hance BF-13 Cationic Guar helps in detangling and improving the manageability of hair.

N-Hance BF-13 Cationic Guar is often included in shampoos to enhance conditioning properties, reduce static, and improve the overall texture of the hair.
The thickening properties of N-Hance BF-13 Cationic Guar make it suitable for use in styling gels and creams, contributing to the desired texture and hold.
N-Hance BF-13 Cationic Guar is commonly used in leave-in conditioners to provide continuous conditioning throughout the day.

N-Hance BF-13 Cationic Guar helps in maintaining hair softness and manageability.
In intensive hair treatments and masks, N-Hance BF-13 Cationic Guar can enhance the conditioning effects, providing deep nourishment to the hair.
In some formulations, N-Hance BF-13 Cationic Guar may be included in body lotions and creams to contribute to the overall texture and skin feel.

In addition to regular conditioners, N-Hance BF-13 Cationic Guar can be included in intensive hair treatments, such as deep conditioning masks or overnight treatments, for enhanced hair nourishment.
Products designed to repair damaged hair may contain N-Hance BF-13 Cationic Guar to provide a reparative and conditioning effect to the hair shaft.
N-Hance BF-13 Cationic Guar can be added to hair gloss or shine sprays to enhance the overall shine and smoothness of the hair.

For hairstyles that require setting or styling, N-Hance BF-13 Cationic Guar can contribute to setting lotions, providing hold and manageability.
In texturizing products designed to create volume or texture in the hair, N-Hance BF-13 Cationic Guar may be used to enhance the product's consistency.
Products aimed at increasing hair volume, such as mousses or volumizing sprays, may include N-Hance BF-13 Cationic Guar to contribute to the overall formulation.

In cleansing conditioners or co-washes, where hair cleansing and conditioning are combined, N-Hance BF-13 Cationic Guar can play a role in providing conditioning benefits.
N-Hance BF-13 Cationic Guar may be incorporated into hair pomades or styling waxes to contribute to the product's texture and conditioning properties.
Products designed for textured or ethnic hair may contain N-Hance BF-13 Cationic Guar to address specific conditioning needs.

In hair care products formulated for color-treated hair, N-Hance BF-13 Cationic Guar can help maintain the vibrancy of the color while providing conditioning benefits.
As a naturally derived ingredient, N-Hance BF-13 Cationic Guar may be preferred in formulations that prioritize environmentally friendly and sustainable practices.
In certain cosmetic formulations, N-Hance BF-13 Cationic Guar may act as a stabilizer for fragrances, helping to maintain the integrity of the scent.

N-Hance BF-13 Cationic Guar is thickening properties make it suitable for use in liquid soaps and shower gels, contributing to their viscosity and texture.
In some facial cleansers, N-Hance BF-13 Cationic Guar may be used for its conditioning effects.
N-Hance BF-13 Cationic Guar is also found in some pet shampoos and grooming products to provide conditioning benefits for pets' fur.

N-Hance BF-13 Cationic Guar can be used in fabric softeners to provide a soft and conditioned feel to fabrics.
N-Hance BF-13 Cationic Guar is often included in hair serums to provide a lightweight conditioning effect, reducing frizz and enhancing the shine of the hair.
N-Hance BF-13 Cationic Guar can contribute to the formulation's overall texture and help in reducing static, providing a smooth finish.

Some hair color formulations may include N-Hance BF-13 Cationic Guar to improve the texture of the product and to provide conditioning benefits to the hair during and after the coloring process.
N-Hance BF-13 Cationic Guar is used in hair mousse formulations to contribute to the product's texture and provide conditioning effects while styling.
In certain sunscreen lotions or after-sun products, N-Hance BF-13 Cationic Guar may be added for its conditioning properties.

N-Hance BF-13 Cationic Guar can be found in hand lotions, contributing to the formulation's texture and providing a soft and conditioned feel to the skin.
In some deodorant formulations, N-Hance BF-13 Cationic Guar may be included to improve the product's texture and contribute to a smooth application.
Due to its detangling properties, N-Hance BF-13 Cationic Guar is used in hair detangling products to make combing or brushing easier and reduce hair breakage.

Some baby shampoos, lotions, and conditioners may contain N-Hance BF-13 Cationic Guar for its mild conditioning properties.
In certain wet wipe formulations, N-Hance BF-13 Cationic Guar may be used to provide a conditioning effect on the skin.
N-Hance BF-13 Cationic Guar can be included in various hair masks and treatments, providing deep conditioning benefits to nourish and revitalize the hair.

In general cosmetic preparations, such as creams and lotions, N-Hance BF-13 Cationic Guar may be added for its thickening and conditioning effects.
This is the second post in our series on conditioning ingredients.
N-Hance BF-13 Cationic Guar is used in Phique shampoo, as well as several other national brands.
The reason is its ability to make the hair feel smooth as well as target damaged areas that can make hair frizzy.

Safety profile:
Direct contact with the eyes may cause irritation.
In case of eye contact, N-Hance BF-13 Cationic Guar's important to rinse the eyes thoroughly with water.
If irritation persists, seek medical attention.

Some individuals may be sensitive or allergic to certain cosmetic ingredients, including N-Hance BF-13 Cationic Guar.
Skin testing should be conducted before applying products containing this ingredient extensively, especially for individuals with known skin sensitivities.
Inhalation of the dust or aerosolized form of the substance may cause respiratory irritation.

Adequate ventilation should be maintained in areas where the substance is handled in powder form.
While cosmetic products are not intended for ingestion, accidental swallowing may occur.
Ingestion of N-Hance BF-13 Cationic Guar is generally considered low risk, but it's advisable to seek medical attention if it occurs.

N-Hance BF-13 Cationic Guar is a quaternary ammonium compound, and excessive release into the environment can have environmental impacts.
N-Hance BF-13 Cationic Guar's important to follow proper disposal practices and adhere to environmental regulations.

N-HEPTANOIC ACID Bio-Based n-Heptanoic acid n-Heptanoic acid is a seven-carbon linear chain saturated fatty acid that can be used in the form of: Esters in the flavors and fragrances industry, in cosmetics and in industrial lubricants (aviation, refrigeration, automobile, etc.) Salts (sodium heptanoate) for corrosion inhibition Identity CAS number: 111-14-8 Chemical name: n-Heptanoic acid Common name: n-Heptylic acid, Oenanthic acid, Heptanoic acid Arkema is a Founding Member of Pragati: The World's First Sustainable Castor Program The goal of the Pragati project is to enable sustainable castor crop production. Scroll down to learn more about Pragati! Key Properties n-Heptanoic acid - CAS 111-14-8 Purity ≥ 99% 100% of vegetable oil origin (derived from castor oil) 100% linear and saturated carbon chain Chemical formula: CH3-(CH2)5-COOH Main Applications Thanks to its outstanding anti-corrosion properties and its unique performance level at high and low temperatures, bio-based Oleris® n-heptanoic acid is mainly used in lubricants in refrigeration/air conditioning, aviation, aerospace, automotive, etc. Also, it has interesting applications in the form of esters in the flavors and fragrances industry as well as in cosmetics. Lubricant Applications Seven carbon atoms in the linear chain yields a good balance in terms of low viscosity at low temperature and low volatility at high temperature. Gears of Titanium and Steel n-heptanoic acid is used in lubricants in the form of esters (e.g. neopolyol ester) with: Improved fluidity at low temperature, higher than with nearby C6/C8/C10 High thermal stability Good resistance to oxidation These esters are used primarily in applications for the automotive sector (car motor oils), in metalworking fluids, and as plasticizers etc. Flavors and Fragrances Applications n-Heptanoic acid, of 100% of vegetable origin (bio-based), is used as a chemical intermediate in the synthesis of esters from C1 to C9 alcohols. These esters present fruity, green, herbal or floral notes. Pink Perfume Bottles and Petals More than 25 aromatic esters from heptanoic acid are possible, like: In flavors: Ethyl heptanoate or allyl heptanoate with fruity or pineapple notes are commonly used In fragrances: Nonyl heptanoate is particulary appreciated for its orange floral rose notes Cosmetic Applications Brown Make-up Pencil n-Heptanoic acid is used as a chemical intermediate in the synthesis of bio-based cosmetics: Emollients Skin conditioning agents Viscosity controlling agents Like Stearyl heptanoate, Glyceryl triheptanoate, etc. INCI name: heptanoic acid Anti-corrosion Applications n-Heptanoic acid is a very effective corrosion inhibitor to protect copper, iron, aluminum and zinc when used as a salt derivative (sodium heptanoate). This heptanoic acid shows good stability in hard water which prevents the precipitation of calcium. Coatings This salt of heptanoic acid is widely used in: Metalworking fluids Water-based hydraulic fluids for anti-freeze application Industrial water-based refrigerants Temporary protection Anticorrosion additive for paints Cutting oils n-heptanoic acid certifications Ecocert Cosmetics logo n-heptanoic acid is Kosher certificated, free of BSE-TSE and is GMO free n-heptanoic acid is compliant with the raw materials standard that can be used in the formulation of cosmetics certified according to the Natural and Organic ECOCERT standard, and meets the specifications of the Food Chemical Codex, but is not intended for use as a direct food ingredient For industrial use only N-Heptanoic acid price More Price(18) Manufacturer Product number Product description CAS number Packaging Price Updated Buy Sigma-Aldrich 146870 N-Heptanoic acid 96% 111-14-8 100ml $29 2020-08-18 Buy Sigma-Aldrich 43858 N-Heptanoic acid analytical standard 111-14-8 1ml $73.5 2020-08-18 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 25mL $17 2020-06-24 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 500mL $53 2020-06-24 Buy Alfa Aesar A17704 N-Heptanoic acid, 98+% 111-14-8 500ml $55.4 2020-06-24 Buy N-Heptanoic acid Chemical Properties,Uses,Production Description As an organic compound, N-Heptanoic acid is a seven-carbon linear chain saturated fatty acid with an unpleasant, rancid and pungent odor, which is commonly used as a chemical intermediate in the synthesis of esters for products, such as ethyl heptanoate, that are used in fragrances and artificial flavors. It is also applied in cosmetics for the production of emollients, skin conditioning agents as well as viscosity controlling agents. Besides, N-Heptanoic acid can also act as a industrial lubricant applied in the fields of aviation, refrigeration, automobile, etc. due to its low viscosity at low temperature and low volatility at high temperature. Moreover, the good anti-corrosion property of N-Heptanoic acid results in the usage of metalworking fluids, industrial water-based refrigerants and anti-corrosion additive for paint. N-Heptanoic acid is also applied to esterify steroids in the field of pharmaceutical to produce drugs such as testosterone enanthate, trenbolone enanthate, drostanolone enanthate, methenolone enanthate and it is also one of numerous additives in cigarettes. References https://en.wikipedia.org/wiki/Heptanoic_acid https://pubchem.ncbi.nlm.nih.gov/compound/8094#section=Top http://www.arkema.com/en/products/product-finder/product-viewer/Oleris-n-Heptanoic-acid/ Description N-Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven - carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It contributes to the odor of some rancid oils. It is slightly soluble in water, but very soluble in ethanol and ether. Chemical Properties N-Heptanoic acid has a disagreeable rancid odor. The spectroscopically pure acid exhibits a faint tallow-like odor. N-Heptanoic acid may be prepared by oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Chemical Properties N-Heptanoic acid has a disagreeable rancid, sour, sweat-like, fatty odor The spectroscopically pure acid exhibits a faint fallow-like odor. Chemical Properties colourless liquid with a pungent and rancid odour Occurrence Reported as occurring naturally in calamus, hops, Acacia dealbata, and Japanese peppermint and violet leaves; its presence in rancid oils has been observed Also reported found in passion fruit, mandarin orange peel oil, guava, apple, banana, grapes, papaya, raspberry, strawberry, kiwi, baked potato, sauerkraut, tomato, breads, cheeses, butter, milk, fsh, fsh oil, meats, chicken fat, pork fat, hop oil, beer, cognac, brandy, rum, grape wines, sherry, whiskies, sake, peated malt, cocoa, coffee, tea, soy protein, peanuts, pecans, coconut, beans, mushroom, fenugreek, mango, fgs, licorice, corn oil, shrimps, scallops and other sources Uses Intermediates of Liquid Crystals Uses There are two major uses for N-Heptanoic acid. One is in vinyl plasticizers that are used primarily in the automotive market.This market is expected to grow 3 to 4% per year with GNP.The second is in synthetic lubricants, where N-Heptanoic acid is used in polyol esters.The market for polyol esters is primarily for use in commercial and military jet turbine lubricants.There is a small market for these esters in the automotive lubricant area, but there has been limited acceptance of these products by automakers and the public.The growth of the polyol ester market is expected to track GNP, unless automakers change to support synthetics or unless there is an elevation of military activity. The use of N-Heptanoic acid in high-water metalworking fluids has grown in excess of 20% over the last several years.The amount of acid used in these products is small; therefore, a dramatic change from the traditional oil-based fluids would be required before there would be significant market impact. Definition ChEBI: A C7, straight-chain fatty acid that contributes to the odour of some rancid oils. Used in the preparation of esters for the fragrance industry, and as an additive in cigarettes. Production Methods The methyl ester of ricinoleic acid, obtained from castor bean oil is the main commercial precursor to N-Heptanoic acid. It is hydrolyzed to the methyl ester of [[undecenoic acid]] and heptanal, which is then air oxidized to the carboxylic acid. Approximately 20,000 tons were consumed in Europe and US in 1980. Ricinoleic acid is the main precursor to N-Heptanoic acid. N-Heptanoic acid is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. N-Heptanoic acid is used to esterify steroids in the preparation of drugs such as as testosterone enanthate, trenbolone enanthate, drostanolone enanthate and methenolone enanthate (Primobolan). It is also one of many additives in cigarettes. Preparation By oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Taste threshold values Taste characteristics at 5 ppm: waxy, cheesy, fruity, dirty and fatty. Synthesis Reference(s) Organic Syntheses, Coll. Vol. 2, p. 315, 1943 The Journal of Organic Chemistry, 58, p. 4745, 1993 Tetrahedron Letters, 21, p. 2181, 1980 DOI: 10.1016/S0040-4039(00)78992-1 General Description A colorless liquid with a pungent odor. Less dense than water and poorly soluble in water. Hence floats on water. Very corrosive. Contact may likely burn skin, eyes, and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Flash point near 200°F. Air & Water Reactions Slightly soluble in water. Reactivity Profile N-Heptanoic acid reacts exothermically with bases. Can react, particularly if moist, with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow if the acid remains dry. Corrodes or dissolves iron, steel, and aluminum parts and containers under ordinary conditions. Reacts with cyanide salts to generate gaseous hydrogen cyanide, particuarly if moist. May generate flammable and/or toxic gases with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts exothermically with carbonates and bicarbonates to generate a harmless gas (carbon dioxide). Can be oxidized exothermically by strong oxidizing agents and reduced exothermically by strong reducing agents. A wide variety of products is possible. May initiate polymerization reactions; may catalyze chemical reactions. Hazard Combustible. Health Hazard Harmful if swallowed, inhaled, or absorbed through skin. Extremely destructive to mucous membranes, upper respiratory tract, skin, and eyes. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Fire Hazard N-Heptanoic acid is probably combustible. N-Heptanoic acid Preparation Products And Raw materials Bio-Based n-Heptanoic acid n-Heptanoic acid is a seven-carbon linear chain saturated fatty acid that can be used in the form of: Esters in the flavors and fragrances industry, in cosmetics and in industrial lubricants (aviation, refrigeration, automobile, etc.) Salts (sodium heptanoate) for corrosion inhibition Identity CAS number: 111-14-8 Chemical name: n-Heptanoic acid Common name: n-Heptylic acid, Oenanthic acid, Heptanoic acid Arkema is a Founding Member of Pragati: The World's First Sustainable Castor Program The goal of the Pragati project is to enable sustainable castor crop production. Scroll down to learn more about Pragati! Key Properties n-Heptanoic acid - CAS 111-14-8 Purity ≥ 99% 100% of vegetable oil origin (derived from castor oil) 100% linear and saturated carbon chain Chemical formula: CH3-(CH2)5-COOH Main Applications Thanks to its outstanding anti-corrosion properties and its unique performance level at high and low temperatures, bio-based Oleris® n-heptanoic acid is mainly used in lubricants in refrigeration/air conditioning, aviation, aerospace, automotive, etc. Also, it has interesting applications in the form of esters in the flavors and fragrances industry as well as in cosmetics. Lubricant Applications Seven carbon atoms in the linear chain yields a good balance in terms of low viscosity at low temperature and low volatility at high temperature. Gears of Titanium and Steel n-heptanoic acid is used in lubricants in the form of esters (e.g. neopolyol ester) with: Improved fluidity at low temperature, higher than with nearby C6/C8/C10 High thermal stability Good resistance to oxidation These esters are used primarily in applications for the automotive sector (car motor oils), in metalworking fluids, and as plasticizers etc. Flavors and Fragrances Applications n-Heptanoic acid, of 100% of vegetable origin (bio-based), is used as a chemical intermediate in the synthesis of esters from C1 to C9 alcohols. These esters present fruity, green, herbal or floral notes. Pink Perfume Bottles and Petals More than 25 aromatic esters from heptanoic acid are possible, like: In flavors: Ethyl heptanoate or allyl heptanoate with fruity or pineapple notes are commonly used In fragrances: Nonyl heptanoate is particulary appreciated for its orange floral rose notes Cosmetic Applications Brown Make-up Pencil n-Heptanoic acid is used as a chemical intermediate in the synthesis of bio-based cosmetics: Emollients Skin conditioning agents Viscosity controlling agents Like Stearyl heptanoate, Glyceryl triheptanoate, etc. INCI name: heptanoic acid Anti-corrosion Applications n-Heptanoic acid is a very effective corrosion inhibitor to protect copper, iron, aluminum and zinc when used as a salt derivative (sodium heptanoate). This heptanoic acid shows good stability in hard water which prevents the precipitation of calcium. Coatings This salt of heptanoic acid is widely used in: Metalworking fluids Water-based hydraulic fluids for anti-freeze application Industrial water-based refrigerants Temporary protection Anticorrosion additive for paints Cutting oils n-heptanoic acid certifications Ecocert Cosmetics logo n-heptanoic acid is Kosher certificated, free of BSE-TSE and is GMO free n-heptanoic acid is compliant with the raw materials standard that can be used in the formulation of cosmetics certified according to the Natural and Organic ECOCERT standard, and meets the specifications of the Food Chemical Codex, but is not intended for use as a direct food ingredient For industrial use only N-Heptanoic acid price More Price(18) Manufacturer Product number Product description CAS number Packaging Price Updated Buy Sigma-Aldrich 146870 N-Heptanoic acid 96% 111-14-8 100ml $29 2020-08-18 Buy Sigma-Aldrich 43858 N-Heptanoic acid analytical standard 111-14-8 1ml $73.5 2020-08-18 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 25mL $17 2020-06-24 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 500mL $53 2020-06-24 Buy Alfa Aesar A17704 N-Heptanoic acid, 98+% 111-14-8 500ml $55.4 2020-06-24 Buy N-Heptanoic acid Chemical Properties,Uses,Production Description As an organic compound, N-Heptanoic acid is a seven-carbon linear chain saturated fatty acid with an unpleasant, rancid and pungent odor, which is commonly used as a chemical intermediate in the synthesis of esters for products, such as ethyl heptanoate, that are used in fragrances and artificial flavors. It is also applied in cosmetics for the production of emollients, skin conditioning agents as well as viscosity controlling agents. Besides, N-Heptanoic acid can also act as a industrial lubricant applied in the fields of aviation, refrigeration, automobile, etc. due to its low viscosity at low temperature and low volatility at high temperature. Moreover, the good anti-corrosion property of N-Heptanoic acid results in the usage of metalworking fluids, industrial water-based refrigerants and anti-corrosion additive for paint. N-Heptanoic acid is also applied to esterify steroids in the field of pharmaceutical to produce drugs such as testosterone enanthate, trenbolone enanthate, drostanolone enanthate, methenolone enanthate and it is also one of numerous additives in cigarettes. References https://en.wikipedia.org/wiki/Heptanoic_acid https://pubchem.ncbi.nlm.nih.gov/compound/8094#section=Top http://www.arkema.com/en/products/product-finder/product-viewer/Oleris-n-Heptanoic-acid/ Description N-Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven - carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It contributes to the odor of some rancid oils. It is slightly soluble in water, but very soluble in ethanol and ether. Chemical Properties N-Heptanoic acid has a disagreeable rancid odor. The spectroscopically pure acid exhibits a faint tallow-like odor. N-Heptanoic acid may be prepared by oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Chemical Properties N-Heptanoic acid has a disagreeable rancid, sour, sweat-like, fatty odor The spectroscopically pure acid exhibits a faint fallow-like odor. Chemical Properties colourless liquid with a pungent and rancid odour Occurrence Reported as occurring naturally in calamus, hops, Acacia dealbata, and Japanese peppermint and violet leaves; its presence in rancid oils has been observed Also reported found in passion fruit, mandarin orange peel oil, guava, apple, banana, grapes, papaya, raspberry, strawberry, kiwi, baked potato, sauerkraut, tomato, breads, cheeses, butter, milk, fsh, fsh oil, meats, chicken fat, pork fat, hop oil, beer, cognac, brandy, rum, grape wines, sherry, whiskies, sake, peated malt, cocoa, coffee, tea, soy protein, peanuts, pecans, coconut, beans, mushroom, fenugreek, mango, fgs, licorice, corn oil, shrimps, scallops and other sources Uses Intermediates of Liquid Crystals Uses There are two major uses for N-Heptanoic acid. One is in vinyl plasticizers that are used primarily in the automotive market.This market is expected to grow 3 to 4% per year with GNP.The second is in synthetic lubricants, where N-Heptanoic acid is used in polyol esters.The market for polyol esters is primarily for use in commercial and military jet turbine lubricants.There is a small market for these esters in the automotive lubricant area, but there has been limited acceptance of these products by automakers and the public.The growth of the polyol ester market is expected to track GNP, unless automakers change to support synthetics or unless there is an elevation of military activity. The use of N-Heptanoic acid in high-water metalworking fluids has grown in excess of 20% over the last several years.The amount of acid used in these products is small; therefore, a dramatic change from the traditional oil-based fluids would be required before there would be significant market impact. Definition ChEBI: A C7, straight-chain fatty acid that contributes to the odour of some rancid oils. Used in the preparation of esters for the fragrance industry, and as an additive in cigarettes. Production Methods The methyl ester of ricinoleic acid, obtained from castor bean oil is the main commercial precursor to N-Heptanoic acid. It is hydrolyzed to the methyl ester of [[undecenoic acid]] and heptanal, which is then air oxidized to the carboxylic acid. Approximately 20,000 tons were consumed in Europe and US in 1980. Ricinoleic acid is the main precursor to N-Heptanoic acid. N-Heptanoic acid is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. N-Heptanoic acid is used to esterify steroids in the preparation of drugs such as as testosterone enanthate, trenbolone enanthate, drostanolone enanthate and methenolone enanthate (Primobolan). It is also one of many additives in cigarettes. Preparation By oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Taste threshold values Taste characteristics at 5 ppm: waxy, cheesy, fruity, dirty and fatty. Synthesis Reference(s) Organic Syntheses, Coll. Vol. 2, p. 315, 1943 The Journal of Organic Chemistry, 58, p. 4745, 1993 Tetrahedron Letters, 21, p. 2181, 1980 DOI: 10.1016/S0040-4039(00)78992-1 General Description A colorless liquid with a pungent odor. Less dense than water and poorly soluble in water. Hence floats on water. Very corrosive. Contact may likely burn skin, eyes, and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Flash point near 200°F. Air & Water Reactions Slightly soluble in water. Reactivity Profile N-Heptanoic acid reacts exothermically with bases. Can react, particularly if moist, with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow if the acid remains dry. Corrodes or dissolves iron, steel, and aluminum parts and containers under ordinary conditions. Reacts with cyanide salts to generate gaseous hydrogen cyanide, particuarly if moist. May generate flammable and/or toxic gases with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts exothermically with carbonates and bicarbonates to generate a harmless gas (carbon dioxide). Can be oxidized exothermically by strong oxidizing agents and reduced exothermically by strong reducing agents. A wide variety of products is possible. May initiate polymerization reactions; may catalyze chemical reactions. Hazard Combustible. Health Hazard Harmful if swallowed, inhaled, or absorbed through skin. Extremely destructive to mucous membranes, upper respiratory tract, skin, and eyes. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Fire Hazard N-Heptanoic acid is probably combustible. N-Heptanoic acid Preparation Products And Raw materials

N-Hexyl Cellosolve is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-Hexyl Cellosolve, as known 2-Hexoxyethanol or 2-(Hexyloxy)ethanol, is a glycol ether that has a chemical formula of C8H18O2.
N-Hexyl Cellosolve enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.


CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2


n-Hexyl Cellosolve is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-Hexyl Cellosolve has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, n-Hexyl Cellosolve provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
n-Hexyl Cellosolve has a high boiling point, slow evaporating solvent with excellent solvency characteristics.


n-Hexyl Cellosolve has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, n-Hexyl Cellosolve provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
n-Hexyl Cellosolve is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
n-Hexyl Cellosolve is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.


n-Hexyl Cellosolve's miscibility with water, however, is limited.
n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since n-Hexyl Cellosolve may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2,6-di-tert-butyl-para cresol (butylated hydroxytoluene – BHT).


n-Hexyl Cellosolve is a Glycol ether solvent.
n-Hexyl Cellosolve Solvent is a high boiling point, slow evaporating rate solvent with excellent solvencycharacteristics.
n-Hexyl Cellosolve has the characteristic structure of glycol ethers and contains both ether and alcohol functionalgroups in the same molecule.
N-Hexyl Cellosolve (Ethylene Glycol Monohexyl Ether), n°112-25-4 is measured by GC-FID.


N-Hexyl Cellosolve's vapour is heavier than air.
N-Hexyl Cellosolve is a colorless liquid with a slight ether odor and bitter taste.
N-Hexyl Cellosolve (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.


N-Hexyl Cellosolve is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-Hexyl Cellosolve is a colorless liquid with a slight ether-like odor and bitter taste.
Since N-Hexyl Cellosolve may react with the oxygen in the air to form peroxides.
N-Hexyl Cellosolve's miscibility with water, however, is limited.



USES and APPLICATIONS of N-HEXYL CELLOSOLVE:
As a result, n-Hexyl Cellosolve provides unique cleaning power for removal of both water-soluble andgreasy (water insoluble) soils.
N-Hexyl Cellosolve is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.
N-Hexyl Cellosolve is used as special solvent for coating and ink.


N-Hexyl Cellosolve can be used as solvent in specialty printing inks.
The linear hexyl portion of n-Hexyl Cellosolve provides excellent oilsolubility characteristics that make it useful in both consumer and industrial cleaner applications.
N-Hexyl Cellosolve can also be used in printing inks and cleaners.


N-Hexyl Cellosolve is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
N-Hexyl Cellosolve is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
N-Hexyl Cellosolve is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.


n-Hexyl Cellosolve plays an important role in specialty printing inks. Because of its limited water solubility andslow evaporation, n-Hexyl Cellosolve can be used in formulations for the silk screen process to prevent premature setting of the ink.
n-Hexyl Cellosolve is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.


N-Hexyl Cellosolve is used Industry, Scientific Research, Health, Environmental Protection, Agriculture
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.
N-Hexyl Cellosolve serves as a coalescing agent in cleaners and latex paints.
N-Hexyl Cellosolve is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.


N-Hexyl Cellosolve has excellent oil solubility, making it effective in household and industrial cleaning applications.
n-Hexyl Cellosolve is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
n-Hexyl Cellosolve is used as a high-boiling solvent.


n-Hexyl Cellosolve is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
n-Hexyl Cellosolve is used as a coalescing agent in latex paints and cleaners;
n-Hexyl Cellosolve is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.


n-Hexyl Cellosolve possesses high boiling point.
n-Hexyl Cellosolve exhibits very good solvency, superior oil solubility, and slow evaporation rate.
The linear hexyl portion of this provides excellent oil solubility characteristics that make n-Hexyl Cellosolve useful in both consumer and industrial cleaner applications.


n-Hexyl Cellosolve plays an important role in speciality printing inks.
Because of its limited water solubility and slow evaporation, n-Hexyl Cellosolve can be used in formulations for the silk screen process to prevent premature setting of the ink.
N-Hexyl Cellosolve can be used as coalescent for water-borne.


N-Hexyl Cellosolvecan be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
N-Hexyl Cellosolve also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.


N-Hexyl Cellosolve is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
N-Hexyl Cellosolve is used as a high-boiling solvent.
N-Hexyl Cellosolve is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.


N-Hexyl Cellosolve is used as a coalescing agent in latex paints and cleaners.
For instance, it improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, it greatly improves film formation and levelling.


N-Hexyl Cellosolve is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.
Other uses of N-Hexyl Cellosolve are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.


N-Hexyl Cellosolve is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
N-Hexyl Cellosolve is used as high-boiling solvent.
N-Hexyl Cellosolve can be used as primary solvent in solvent-based silk screen printing inks.


N-Hexyl Cellosolve can be used as a solvent in lacquers, paints, resins, dyes, oils and lubricants, as well as as a coupling and dispersant.
N-Hexyl Cellosolve can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
Usage of N-Hexyl Cellosolve: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents


Two solvents, N-Hexyl Cellosolve and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
N-Hexyl Cellosolve is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products


-Uses of n-Hexyl Cellosolve:
*Cosmetics
*Cleaners
*Textiles
*Waterborne coatings
*Cleaning
*Printing ink


-Applications of n-Hexyl Cellosolve:
• Specialty printing inks
• Coalescent for water-borne, latex-based coatings, coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
• Primary solvent in solvent-based silk screen printing inks



BENEFITS OF N-HEXYL CELLOSOLVE:
*High boiling point
*Slow evaporation rate
*Excellent solvency
*Great chemical stability
*Biodegradable
*Compatible with water and a number of organic solvents
*Waterborne coatings: excellent coalescing solvent for water-borne, latex-based coatings
*Cleaning: coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners and disinfectants
*Cleaning: low vapor pressure allows formulating opportunities to address volatile organic compound (VOC) concerns
*Printing ink: especially effective in printing ink formulations for the silk-screen process



ALTERNATIVE PARENTS of N-HEXYL CELLOSOLVE:
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS of N-HEXYL CELLOSOLVE:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of N-HEXYL CELLOSOLVE:
Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -

Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Ų
Rotatable Bond Count: 7

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1

Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7
Exact Mass: 146.130679813
Monoisotopic Mass: 146.130679813
Topological Polar Surface Area: 29.5 Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of N-HEXYL CELLOSOLVE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of N-HEXYL CELLOSOLVE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of N-HEXYL CELLOSOLVE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-HEXYL CELLOSOLVE:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of N-HEXYL CELLOSOLVE:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.



STABILITY and REACTIVITY of N-HEXYL CELLOSOLVE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available



SYNONYMS:
2-(Hexyloxy)ethanol
Cellosolve, n-hexyl-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
Hexyl cellosolve
n-Hexyl cellosolve
C6E1
HEXYLGLYCOL
2-hexyloxyethanol
N-HEXYL CELLOSOLVE
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
ETHYLENE GLYCOL N-HEXYL ETHER
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
2-(Hexyloxy)ethanol;2-HEXOXYETHANOL
AC1L1QF7
AC1Q7D9E
Cellosolve, N-hexyl-
EGHE
Ethanol, 2-(hexyloxy)-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
H0343
Hexyl alcohol, ethoxylated
Hexyl cellosolve
Hexyl poly(oxyethylene) ether
Hexylglycol
Poly(oxy-1,2-ethanediyl), alpha-hexyl-omega-hydroxy-
SBB060173
alpha-Hexyl,omega-hydroxypoly(oxy-1,2-ethanediyl)
n-Hexyl cellosolve
2- (HEXYLOXY) ETHANOL
2-N-(HEXYLOXY) ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYL GLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethane
2-Hexoxyethanol
2-hexyloxy-ethano
Cell fluid, n-hexyl-
ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
glycol monohexyl ether
Hexyl cellosolvation
hexyl cellosolve
n-hexyl-cellosolv
Ethylene gyl carbon mono-N-hexyl ether
Diethylene glycol hexyl ether
2-((2-Hexyloxy)ethoxy)ethanol
Diethylene glycol mono(n-hexyl) ether
Hexol carbitol
Diethylene glycol monohexyl ether
n-Hexoxyethoxyethanol
n-Hexyl carbitol
2-((2-Hexyloxy)ethoxy)ethanol
2-(2-(hexyloxy)ethoxy)ethanol
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(Hexyloxy)ethanol
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
2-Hexyloxy-1-ethanol
Ethylene glycol n-hexyl ether
2-n-(Hexyloxy)ethanol
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
DSSTox_CID_6908
DSSTox_RID_78248
DSSTox_GSID_26908
31726-34-8
Ethanol, 2-hexyloxy-
Ethylene glycol-n-monohexyl ether
HSDB 5569
Hexyl alcohol, ethoxylated
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
Poly(oxy-1,2-ethanediyl), .alpha.-hexyl-.omega.-hydroxy-
ZINC2041054
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
LS-13544
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)

n-hexyl glycol is a glycol ether that has a chemical formula of C8H18O2.
n-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.


CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2 / C6H13OCH2CH2OH


n-hexyl glycol has a high boiling point, slow evaporating solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
n-hexyl glycol is soluble in alcohol and ether, water (9.46 g/L ).


n-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odour.
n-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
n-hexyl glycol's miscibility with water, however, is limited.


n-hexyl glycol enters into the typical reactions of alcohols, e.g. esterification, etherification, oxidation and the formation of alcoholates.
Like all other ethers, n-hexyl glycol may form peroxides if it comes into contact with atmospheric oxygen.
n-hexyl glycol possesses high boiling point.


n-hexyl glycol exhibits very good solvency, superior oil solubility, and slow evaporation rate.
n-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.


n-hexyl glycol is a slow evaporating solvent that partitions primarily into the polymer phase of a waterborne coating and reduces minimum filming temperature.
n-hexyl glycol is a high boiling point, slow-evaporating rate solvent with excellent solvency characteristics.


n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy soils.
n-hexyl glycol is useful in both consumer and industrial applications and plays an important role in specialty printing inks.
n-hexyl glycol can also go by the name of Hexyl Cellosolve.


n-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.


n-hexyl glycol Solvent is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
n-hexyl glycol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 tonnes per annum.



USES and APPLICATIONS of n-HEXYL GLYCOL:
n-hexyl glycol is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.
n-hexyl glycol can be used with associative thickeners to enhance application properties such as brushability or roll application in high performance coatings.


n-hexyl glycol is a high boiling point, slow evaporating solvent with excellent solvency characteristics.
n-hexyl glycol may be used to coalesce waterborne latex coatings and to balance solvency and volatility in high solids coatings.
As a result, n-hexyl glycol provides unique cleaning power for the removal of both water-soluble and greasy (water-insoluble) soils.


The linear hexyl portion of n-hexyl glycol provides excellent oil solubility characteristics that make it useful in both consumer and industrial cleaner applications.
n-hexyl glycol plays an important role in specialty printing inks.


Because of its limited water solubility and slow evaporation, n-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.
n-hexyl glycol is used specialty printing inks


n-hexyl glycol is used coalescent for water-borne, latex-based coatings, coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
n-hexyl glycol is used primary solvent in solvent-based silk screen printing inks


As a result, n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of this provides excellent oil solubility characteristics that make n-hexyl glycol useful in both consumer and industrial cleaner applications.


n-hexyl glycol plays an important role in specialty printing inks.
Because of n-hexyl glycol limited water solubility and slow evaporation, it can be used in formulations for the silk screen process to prevent premature setting of the ink.


n-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
The structure of n-hexyl glycol provides a unique cleaning power that can remove a wider array of soils.
With the characteristic structures of glycol ethers, n-hexyl glycol contains ether and alcohol functional groups in the same molecule.


n-hexyl glycol is used in the production of cleaning products and as a diluent for printing inks.
Uses of n-hexyl glycol: Cosmetics, Cleaners, Textiles, Waterborne, coatings, Cleaning, and Printing ink
n-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.


n-hexyl glycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
n-hexyl glycol is used as high-boiling solvent.
n-hexyl glycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.


n-hexyl glycol serves as a coalescing agent in cleaners and latex paints.
Other uses of 2-Hexoxyethanol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.


n-hexyl glycol is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.
n-hexyl glycol possesses high boiling point.


n-hexyl glycol exhibits very good solvency, superior oil solubility, and slow evaporation rate.
n-hexyl glycol can be used as solvent in specialty printing inks.
n-hexyl glycol can be used as coalescent for water-borne.


n-hexyl glycol can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
n-hexyl glycol can be used as primary solvent in solvent-based silk screen printing inks.
n-hexyl glycol is used Coalescent for water-borne, latex-based coatings, Coupling agent and solvent in rust removers, hard surface cleaners and disinfectants, Specialty Printing Inks, Screen Printing Inks.


As a result, n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of n-hexyl glycol provides excellent oil solubility characteristics that make it useful in both consumer and industrial cleaner applications.


n-hexyl glycol plays an important role in specialty printing inks.
Because of its limited water solubility and slow evaporation, n-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.


n-hexyl glycol can also be used in printing inks and cleaners.
n-hexyl glycol is mainly used as a solvent, flow promoter, and coalescent aid in the coatings industry and in printing inks and cleaners.
n-hexyl glycol is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay, lubricants and greases, adhesives and sealants, anti-freeze products, finger paints, washing & cleaning products and polishes and waxes.
Other release to the environment of n-hexyl glycol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay and polymers.
n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay and polymers.
Release to the environment of n-hexyl glycol can occur from industrial use: formulation of mixtures.


n-hexyl glycol is used for the manufacture of: chemicals.
Release to the environment of n-hexyl glycol can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates) and manufacturing of the substance.


n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay and polymers.
Release to the environment of n-hexyl glycol can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).


-n-hexyl glycol as biodegradable cleaning power:
As part of an n-hexyl glycol-proven portfolio of home and institutional care applications, a biodegradable glycol ether solvent removes both water-soluble and greasy, water-insoluble soils.

n-hexyl glycol maintains excellent solvency characteristics without compromising environmental standards, allowing for uniform diffusion and reduced defects due to solvent-pop and air entrapment in formulations.
The structure of n-hexyl glycol provides a unique cleaning power that can remove a wider array of soils.
With the characteristic structures of glycol ethers, n-hexyl glycol contains ether and alcohol functional groups in the same molecule.


-Applications of n-hexyl glycol:
• Solvent in specialty printing inks
• Coalescent for water-borne, latex-based coatings
• Coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
• Primary solvent in solvent-based silk screen printing inks


-Coatings industry uses of n-hexyl glycol:
By virtue of its good solvent power, the main applications of n-hexyl glycol are as a solvent, flow promoter and coalescent aid.
For instance, n-hexyl glycol improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, n-hexyl glycol greatly improves film formation and levelling.
n-hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.



BENEFITS OF n-HEXYL GLYCOL:
-High boiling point
-Slow evaporation rate
-Excellent solvency
-Great chemical stability
-Compatible with water and a number of organic solvents
-Waterborne coatings: excellent coalescing solvent for water-borne, latex-based coatings
-Cleaning: coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners and disinfectants
-Cleaning: low vapor pressure allows formulating opportunities to address volatile organic compound (VOC) concerns
-Printing ink: especially effective in printing ink formulations for the silk-screen process



PHYSICAL and CHEMICAL PROPERTIES of n-HEXYL GLYCOL:
Molecular Formula: C8H18O2
Molar Mass: 146.23
Density: 0.888g/mLat 20°C(lit.)
Melting Point: -45.1℃
Boling Point: 98-99°C 0,15mm
Flash Point: 98-99°C/0.15mm
Water Solubility: Soluble in alcohol and ether, water (9.46 g/L ).
Vapor Presure: 10 Pa at 20℃
Appearance: clear liquid
Color: Colorless to Light yellow
BRN: 1734691
pKa: 14.44±0.10(Predicted)
Storage Condition: -15°C
Refractive Index: n20/D 1.431
Molecular Weight: 146.23 g/mol
XLogP3: 1.9
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7

Exact Mass: 146.130679813 g/mol
Monoisotopic Mass: 146.130679813 g/mol
Topological Polar Surface Area: 29.5Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical formula: C8H18O2
Molar mass: 146.230 g·mol−1
Appearance: Colorless hygroscopic liquid
Odor: Characteristic
Density: 0.89
Melting point: −45 °C (−49 °F; 228 K)
Boiling point: 208.3 °C (406.9 °F; 481.4 K)

Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.93400 to 0.93700 @ 20.00 °C.
Pounds per Gallon - (est).: 7.781 to 7.806
Refractive Index: 1.43600 to 1.43800 @ 20.00 °C.
Melting Point: -28.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 260.00 °C. @ 760.00 mm Hg
Vapor Pressure: 5.030000 mmHg @ 25.00 °C. (est)
Flash Point: 284.00 °F. TCC ( 140.00 °C. )
logP (o/w): 1.700
Soluble in: water, 1.70E+04 mg/L @ 20 °C (exp)
water, 5602 mg/L @ 25 °C (est)
Vapor Pressure: 0.05 mmHg (@20°C)
Surface Tension: 27.7 dynes/cm (@25°C)
Solubility in water: 0.9 g/100g (@20°C)
Flash Point: 210°F
Viscosity: 5.2 cP (@25°C)
Molecular weight: 146.2
Boiling Point: 406°F
Freezing Point: -49°F

Specific Heat: 2.296 J/g/°C (@25°C)
Auto Ignition Temp: 536°F
Specific gravity: 0.889 (20/20°C)
Evaporation Rate: <0.01
Refractive Index: 1.4290 (20 c)
Melting point: -45.1℃
Boiling point: 98-99°C 0,15mm
Density: 0.888 g/mL at 20 °C(lit.)
vapor pressure: 10 Pa at 20℃
refractive index: n20/D 1.431
Flash point: 98-99°C/0.15mm
storage temp.: -15°C
pka: 14.44±0.10(Predicted)
form: clear liquid
color: Colorless to Light yellow
Water Solubility: Soluble in alcohol and ether, water (9.46 g/L ).
BRN: 1734691
LogP: 1.97 at 25℃
CAS: 112-25-4
EINECS: 203-951-1
InChI: InChI=1/C12H26O.C2H6O2.C2H4/c1-3-5-7-9-11-13-12-10-8-6-4-2;3-1-2-4;1-2/h3-12H2,1-2H3;3-4H,1-2H2;1-2H2



FIRST AID MEASURES of n-HEXYL GLYCOL:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of n-HEXYL GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of n-HEXYL GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of n-HEXYL GLYCOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of n-HEXYL GLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.



STABILITY and REACTIVITY of n-HEXYL GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available



SYNONYMS:
C6E1
HEXYLGLYCOL
2-hexyloxyethanol
N-HEXYL CELLOSOLVE
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
ETHYLENE GLYCOL N-HEXYL ETHER
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
N-HEXYL CELLOSOLVE
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
2-(Hexyloxy)ethanol
112-25-4
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
Ethylene glycol n-hexyl ether
2-Hexyloxy-1-ethanol
DTXSID1026908
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
31726-34-8
DTXCID606908
Ethanol, 2-hexyloxy-
2-(hexyloxy)ethan-1-ol
CAS-112-25-4
Ethylene glycol-n-monohexyl ether
HSDB 5569
2-n-(Hexyloxy)ethanol
EINECS 203-951-1
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
SCHEMBL24741
4-01-00-02383 (Beilstein Handbook Reference)
CHEMBL3188016
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
FT-0631642
H0343
EN300-114321
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)
n-Hexyl Cellosolve
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Glycol monohexyl ether
Hexyl cellosolve
2-(Hexyloxy)ethanol
2-Hexoxyethanol
Ethylene glycol mono-n-hexyl ether
Cellosolve, n-hexyl-
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
N-HEXYL CELLOSOLVE
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
2-(Hexyloxy)ethanol
2-HEXOXYETHANOL
AC1L1QF7
AC1Q7D9E
Cellosolve, N-hexyl-
EGHE
Ethanol, 2-(hexyloxy)-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
H0343
Hexyl alcohol, ethoxylated
Hexyl cellosolve
Hexyl poly(oxyethylene) ether
Hexylglycol
Poly(oxy-1,2-ethanediyl), alpha-hexyl-omega-hydroxy-
SBB060173
alpha-Hexyl,omega-hydroxypoly(oxy-1,2-ethanediyl)
n-Hexyl cellosolve
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
N-HEXYL CELLOSOLVE
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL

N-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
N-hexyl glycol, as known 2-Hexoxyethanol or 2-(Hexyloxy)ethanol, is a glycol ether that has a chemical formula of C8H18O2.


CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2


N-hexyl glycol (Ethylene Glycol Monohexyl Ether), n°112-25-4 is measured by GC-FID.
N-hexyl glycol's vapour is heavier than air.
N-hexyl glycol is a colorless liquid with a slight ether odor and bitter taste.
N-hexyl glycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.


N-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-hexyl glycol's miscibility with water, however, is limited.


n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since N-hexyl glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2,6-di-tert-butyl-para cresol (butylated hydroxytoluene – BHT).
N-hexyl glycol is a colorless liquid with a slight ether-like odor and bitter taste


Since N-hexyl glycol may react with the oxygen in the air to form peroxides.
N-hexyl glycol's miscibility with water, however, is limited.
N-hexyl glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
N-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.


N-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.


As a result, N-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
N-hexyl glycol has a high boiling point, slow evaporating solvent with excellent solvency characteristics.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.


N-hexyl glycol is a Glycol ether solvent.
N-hexyl glycol Solvent is a high boiling point, slow evaporating rate solvent with excellent solvencycharacteristics.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functionalgroups in the same molecule.



USES and APPLICATIONS of N-HEXYL GLYCOL:
N-hexyl glycol is used Industry, Scientific Research, Health, Environmental Protection, Agriculture
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.
N-hexyl glycol serves as a coalescing agent in cleaners and latex paints.


N-hexyl glycol has excellent oil solubility, making it effective in household and industrial cleaning applications.
N-hexyl glycol is used as a high-boiling solvent.
N-hexyl glycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
N-hexyl glycol is used as a coalescing agent in latex paints and cleaners.


For instance, it improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, it greatly improves film formation and levelling.
N-hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.


N-hexyl glycol plays an important role in speciality printing inks.
Because of its limited water solubility and slow evaporation, N-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.


N-hexyl glycol can also be used in printing inks and cleaners.
Usage of N-hexyl glycol: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
N-hexyl glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
N-hexyl glycol is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.


N-hexyl glycol is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
Other uses of N-hexyl glycol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.


N-hexyl glycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
N-hexyl glycol is used as a coalescing agent in latex paints and cleaners;
N-hexyl glycol is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.


N-hexyl glycol possesses high boiling point.
N-hexyl glycol exhibits very good solvency, superior oil solubility, and slow evaporation rate.
The linear hexyl portion of this provides excellent oil solubility characteristics that make N-hexyl glycol useful in both consumer and industrial cleaner applications.


N-hexyl glycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
N-hexyl glycol is used as high-boiling solvent.
N-hexyl glycol can be used as a solvent in lacquers, paints, resins, dyes, oils and lubricants, as well as as a coupling and dispersant.


N-hexyl glycol can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
N-hexyl glycol can be used as coalescent for water-borne.
N-hexyl glycolcan be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.


N-hexyl glycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
N-hexyl glycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .


Two solvents, N-hexyl glycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
N-hexyl glycol is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products


N-hexyl glycol can be used as primary solvent in solvent-based silk screen printing inks.
N-hexyl glycol is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.
N-hexyl glycol is used as special solvent for coating and ink.


N-hexyl glycol can be used as solvent in specialty printing inks.
As a result, N-hexyl glycol provides unique cleaning power for removal of both water-soluble andgreasy (water insoluble) soils.
The linear hexyl portion of N-hexyl glycol provides excellent oilsolubility characteristics that make it useful in both consumer and industrial cleaner applications.


N-hexyl glycol plays an important role in specialty printing inks. Because of its limited water solubility andslow evaporation, N-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.
N-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.


N-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
N-hexyl glycol is used as a high-boiling solvent.
N-hexyl glycol is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.


-Uses of N-hexyl glycol:
*Cosmetics
*Cleaners
*Textiles
*Waterborne coatings
*Cleaning
*Printing ink


-Applications of N-hexyl glycol:
• Specialty printing inks
• Coalescent for water-borne, latex-based coatings, coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
• Primary solvent in solvent-based silk screen printing inks



ALTERNATIVE PARENTS of N-HEXYL GLYCOL:
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS of N-HEXYL GLYCOL:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of N-HEXYL GLYCOL:
Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -

Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Ų
Rotatable Bond Count: 7

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1

Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7
Exact Mass: 146.130679813
Monoisotopic Mass: 146.130679813
Topological Polar Surface Area: 29.5 Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of N-HEXYL GLYCOL:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of N-HEXYL GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of N-HEXYL GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-HEXYL GLYCOL:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of N-HEXYL GLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.



STABILITY and REACTIVITY of N-HEXYL GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available



SYNONYMS:
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(Hexyloxy)ethanol
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
2-Hexyloxy-1-ethanol
Ethylene glycol n-hexyl ether
2-n-(Hexyloxy)ethanol
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
DSSTox_CID_6908
DSSTox_RID_78248
DSSTox_GSID_26908
31726-34-8
Ethanol, 2-hexyloxy-
Ethylene glycol-n-monohexyl ether
HSDB 5569
Hexyl alcohol, ethoxylated
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
Poly(oxy-1,2-ethanediyl), .alpha.-hexyl-.omega.-hydroxy-
ZINC2041054
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
LS-13544
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)
2-(Hexyloxy)ethanol
Cellosolve, n-hexyl-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
Hexyl cellosolve
n-Hexyl cellosolve
C6E1
HEXYLGLYCOL
2-hexyloxyethanol
N-HEXYL CELLOSOLVE
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
ETHYLENE GLYCOL N-HEXYL ETHER
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
2-(Hexyloxy)ethanol;2-HEXOXYETHANOL
AC1L1QF7
AC1Q7D9E
Cellosolve, N-hexyl-
EGHE
Ethanol, 2-(hexyloxy)-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
H0343
Hexyl alcohol, ethoxylated
Hexyl cellosolve
Hexyl poly(oxyethylene) ether
Hexylglycol
Poly(oxy-1,2-ethanediyl), alpha-hexyl-omega-hydroxy-
SBB060173
alpha-Hexyl,omega-hydroxypoly(oxy-1,2-ethanediyl)
n-Hexyl cellosolve
2- (HEXYLOXY) ETHANOL
2-N-(HEXYLOXY) ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYL GLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethane
2-Hexoxyethanol
2-hexyloxy-ethano
Cell fluid, n-hexyl-
ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
glycol monohexyl ether
Hexyl cellosolvation
hexyl cellosolve
n-hexyl-cellosolv
Ethylene gyl carbon mono-N-hexyl ether
Diethylene glycol hexyl ether
2-((2-Hexyloxy)ethoxy)ethanol
Diethylene glycol mono(n-hexyl) ether
Hexol carbitol
Diethylene glycol monohexyl ether
n-Hexoxyethoxyethanol
n-Hexyl carbitol
2-((2-Hexyloxy)ethoxy)ethanol
2-(2-(hexyloxy)ethoxy)ethanol

DESCRIPTION:
N-hexyl glycol is Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
N-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.


CAS number: 112-25-4
EC number: 203-951-1
Molecular formula: C8H18O2
Molar mass: 146.23 g/mol

The miscibility of N-hexyl glycol with water, however, is limited.
N-hexyl glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since N-hexyl glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2.6-di-tert-butyl-para-cresol (butylated hydroxytoluene – BHT).

N-hexyl glycol Solvent is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.

As a result, N-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of N-hexyl glycol Solvent provides excellent oil solubility characteristics that make it useful in both consumer and industrial cleaner applications.

N-hexyl glycol Solvent plays an important role in specialty printing inks.
Because of its limited water solubility and slow evaporation, N-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.

CHEMICAL AND PHYSICAL PROPERTIES OF N-HEXYL GLYCOL:
n-Hexylglycol 98.0 min. %
Water 0.1 max. %
Pt/Co color value: (Hazen) 10 max.
Acid value 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml: 200 – 212 °C
Density at 20 °C 0.887 – 0.890 g/cm3
Refractive index nD20: 1.428 – 1.430
Solidification point at 1013 hPa: - 42 °C (ice flakes)
Evaporation rate ether = 1 approx. 1200
Enthalpy of combustion (Δ Hc) at 25 °C: 33 136 kJ/kg
Enthalpy of vaporization (Δ Hv) at 25 °C: 475 kJ/kg
Enthalpy of vaporization (Δ Hv) at boiling point: 325 kJ/kg
Enthalpy of formation (Δ Hf) at 25 °C: - 3 776 kJ/kg
Dipole moment (µ): 2.08 D
Solubility Mass fraction of n-Hexylglycol in water 1.0 %
Water in Hexylglycol 18.8 %
Molecular Weight (g/mol) 146.2
Boiling Point @ 760 mmHg, 1.01 ar 208 °C (406 °F)
Flash Point (Setaflash Closed Cup) 91.5 °C (210°F)
Freezing Point -50 °C (-58°F)
Vapor pressure@ 20°C — extrapolated:
0.05 mmHg
0.01 kPa
Specific gravity (25/25°C) 0.889
Liquid Density @ 20°C 0.888 g/cm3 (7.41 lb/gal)
Vapor Density (air = 1) 5
Viscosity (cP or mPa•s @ 25°C) 4.5
Surface tension (dynes/cm or mN/m @ 20°C) 27.7 (neat product) 27.1 (25% aq. Sol’n)
Specific heat (J/g/°C @ 25°C) 2.296
Heat of vaporization (J/g) at normal boiling point 342.76
Net heat of combustion (kJ/g) — predicted @ 25°C 32.6
Autoignition temperature 225 °C (437 °F)
Evaporation rate (n-butyl acetate = 1.0) <0.01
Solubility, g/L or % @ 20°C
Solvent in water 9.46 g/L


APPLICATIONS OF N-HEXYL GLYCOL:
By virtue of its good solvent power, the main applications of N-Hexyl glycol are as a solvent, flow promoter and coalescent aid.
For instance, N-Hexyl glycol improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, N-Hexyl glycol greatly improves film formation and levelling.

N-Hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders.
N-Hexyl glycol can also be used in printing inks and cleaners.

N-Hexyl glycol is be used as Solvent in specialty printing inks
N-Hexyl glycol is be used as Coalescent for water-borne, latex-based coatings
N-Hexyl glycol is be used as Coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
N-Hexyl glycol is be used as Primary solvent in solvent-based silk screen printing inks

Storage & Handling:
N-Hexyl glycol should be stored under nitrogen.
The storage temperature must not exceed 40 °C and moisture are excluded.
Under these conditions, a storage stability of 12 months can be expected.

SAFETY INFORMATION ABOUT N-HEXYL GLYCOL:

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

N-Hexyl glycol, also known as 2-hexyl-1-ethanol, is an alcohol compound with the chemical formula C₈H₁₈O.
N-Hexyl glycol (2-hexyl-1-ethanol) is an organic compound with a straight-chain hexyl group.
N-Hexyl glycol is classified as a primary alcohol due to the presence of the hydroxyl (-OH) group attached to a primary carbon atom.

CAS Number: 111-27-3
EC Number: 203-872-2



APPLICATIONS


N-Hexyl glycol finds extensive use as a solvent in various industries, including coatings, paints, and varnishes.
N-Hexyl glycol is commonly employed as a coupling agent to aid in the mixing and dispersing of different components in formulations.

N-Hexyl glycol is used in the production of printing inks, providing solvency and enhancing the flow properties of the ink.
N-Hexyl glycol acts as a solvent for textile dyes, aiding in the dyeing and printing processes.
N-Hexyl glycol is utilized as a solvent for adhesives, facilitating their application and bonding properties.

In the cosmetics and personal care industry, N-hexyl glycol can be found in various products such as lotions, creams, and hair care formulations.
N-Hexyl glycol functions as a solvent for active ingredients in pharmaceutical formulations, assisting in their solubility and stability.
N-Hexyl glycol is used as a component in cleaning products, providing solvency and aiding in the removal of dirt and grime.

N-Hexyl glycol serves as a coalescing agent in latex paints, enabling the particles to fuse together and form a continuous film upon drying.
N-Hexyl glycol is employed in the formulation of industrial and household cleaners, contributing to their cleaning efficacy.
N-Hexyl glycol is used as a solvent for resins and polymers in the production of various plastic and rubber products.

N-Hexyl glycol finds application as a solvent and dispersant in the formulation of pesticides and agricultural chemicals.
N-Hexyl glycol is utilized in the formulation of wood coatings and stains, providing solvency and improving the coating's durability.

N-Hexyl glycol is employed in the production of specialty chemicals, including flavors and fragrances.
N-Hexyl glycol is used as a solvent in the formulation of inks for markers and pens.

N-Hexyl glycol finds use in the formulation of industrial degreasers and cleaning solutions for metal surfaces.
N-Hexyl glycol is utilized in the formulation of automotive care products such as polishes and waxes.
N-Hexyl glycol serves as a solvent for corrosion inhibitors in metalworking fluids and rust-preventive coatings.

N-Hexyl glycol finds application in the formulation of oilfield chemicals, such as drilling fluids and well stimulation fluids.
N-Hexyl glycol is used as a solvent for the extraction of natural products and essential oils.

N-Hexyl glycol can be found in the formulation of air fresheners and household fragrance products.
N-Hexyl glycol is employed as a solvent in the production of specialty chemicals used in the electronics industry.
N-Hexyl glycol is used as a solvent and viscosity modifier in the formulation of liquid detergents and cleaning agents.

N-Hexyl glycol serves as a solvent for fragrances and fixatives in the formulation of perfumes and colognes.
N-Hexyl glycol finds application in the formulation of printing chemicals, such as fountain solutions and plate cleaners.

N-Hexyl glycol is used as a solvent in the formulation of industrial and household paints, providing improved flow and dispersion of pigments.
N-Hexyl glycol serves as a wetting agent in agricultural formulations, aiding in the spreading and absorption of pesticides and herbicides on plant surfaces.
N-Hexyl glycol finds application in the formulation of leather and textile finishes, enhancing the softness and durability of the materials.
N-Hexyl glycol is utilized as a solvent for fragrances and essential oils in the production of perfumes, colognes, and body care products.

N-Hexyl glycol acts as a dispersant in the formulation of suspension concentrates and emulsifiable concentrates in the agricultural sector.
N-Hexyl glycol is used as a solvent for resins and binders in the formulation of adhesive and sealant products.
N-Hexyl glycol finds application as a component in antifoam formulations, reducing foam formation in various industrial processes.

N-Hexyl glycol is utilized as a solvent in the formulation of industrial and institutional cleaning products, contributing to their effectiveness.
N-Hexyl glycol is used in the formulation of automotive coatings, providing improved adhesion and durability.
N-Hexyl glycol finds application in the production of specialty chemicals used in the oil and gas industry.

N-Hexyl glycol serves as a solvent for the formulation of wood preservatives, protecting the wood from decay and insect damage.
N-Hexyl glycol is used as a solvent in the formulation of water-based inks for flexographic and gravure printing.

N-Hexyl glycol finds application in the formulation of brake fluids, ensuring proper hydraulic performance in automotive braking systems.
N-Hexyl glycol is utilized as a solvent in the formulation of electroplating baths, facilitating the deposition of metal coatings on substrates.

N-Hexyl glycol is used as a component in corrosion inhibitors, protecting metal surfaces from oxidation and rust.
N-Hexyl glycol finds application in the formulation of industrial lubricants and metalworking fluids, improving their performance and stability.
N-Hexyl glycol is utilized as a solvent for cleaning and degreasing metal surfaces prior to painting or coating applications.
N-Hexyl glycol serves as a solvent and viscosity modifier in the formulation of screen printing inks.

N-Hexyl glycol finds application in the formulation of asphalt emulsions and road construction materials.
N-Hexyl glycol is used as a solvent for the formulation of cleaning agents and degreasers in the automotive and industrial sectors.

N-Hexyl glycol is utilized as a solvent for UV-curable coatings and inks, aiding in their curing process.
N-Hexyl glycol finds application in the formulation of metal cleaners and rust removers.
N-Hexyl glycol serves as a solvent and wetting agent in the formulation of crop protection products in the agriculture industry.

N-Hexyl glycol is used as a solvent for the formulation of personal care products such as hair dyes and hair styling products.
N-Hexyl glycol finds application in the formulation of industrial coolants and heat transfer fluids, ensuring efficient heat exchange.



DESCRIPTION


N-Hexyl glycol, also known as 2-hexyl-1-ethanol, is an alcohol compound with the chemical formula C₈H₁₈O.
N-Hexyl glycol (2-hexyl-1-ethanol) is an organic compound with a straight-chain hexyl group.
N-Hexyl glycol is classified as a primary alcohol due to the presence of the hydroxyl (-OH) group attached to a primary carbon atom.

N-Hexyl glycol has a molecular weight of approximately 130.23 grams per mole.
N-Hexyl glycol appears as a colorless liquid with a mild, pleasant odor.
N-Hexyl glycol is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone.

N-Hexyl glycol is primarily used as a solvent in various applications, including coatings, inks, and cleaning products.
N-Hexyl glycol can act as a coupling agent, facilitating the mixing of different components in a formulation.
N-Hexyl glycol finds use in the manufacturing of paints, varnishes, and adhesives.
As a solvent, it helps to dissolve and disperse pigments, resins, and other ingredients.

N-Hexyl glycol is also employed in the production of textile dyes and printing inks.
In the pharmaceutical industry, it can serve as a solvent for active ingredients.
Due to its low volatility, it contributes to the slow evaporation of formulations.
N-Hexyl glycol can enhance the viscosity and flow properties of certain formulations.

N-Hexyl glycol may also function as a surfactant, reducing surface tension and aiding in wetting and spreading.
N-Hexyl glycol has moderate stability and can withstand various environmental conditions.
N-Hexyl glycol is not highly flammable but should be handled with care.

N-Hexyl glycol has a boiling point of around 205-210°C (401-410°F).
N-Hexyl glycol is stable under normal storage and handling conditions.

N-Hexyl glycol is not known to undergo significant chemical reactions under typical usage scenarios.
N-Hexyl glycol is generally considered safe for use when following appropriate handling guidelines.

N-Hexyl glycol may have slight irritant properties if in direct contact with the skin or eyes.
Adequate ventilation is recommended when using products containing N-hexyl glycol.
N-Hexyl glycol is important to consult safety data sheets and follow regulatory guidelines for proper handling and disposal.

N-Hexyl glycol is not commonly used as a consumer product but rather as an industrial ingredient.
N-Hexyl glycol should be stored in tightly sealed containers away from heat, sparks, or open flames.



PROPERTIES


Chemical Formula: C₈H₁₈O
Molecular Weight: Approximately 130.23 grams per mole
Physical State: Liquid
Appearance: Colorless
Odor: Mild, pleasant odor
Solubility: Sparingly soluble in water, soluble in organic solvents like ethanol and acetone
Boiling Point: Approximately 205-210°C (401-410°F)
Melting Point: -42°C (-43.6°F)
Density: Approximately 0.832 g/cm³ at 20°C (68°F)
Vapor Pressure: Very low
Refractive Index: Approximately 1.426 at 20°C (68°F)
Flash Point: 98°C (208.4°F) (closed cup)
Autoignition Temperature: 305°C (581°F)
Viscosity: Relatively low viscosity
pH Level: Neutral (around 7)
Flammability: Not highly flammable, but it should still be handled with care and stored away from ignition sources.
Stability: Stable under normal storage and handling conditions.
Reactivity: Not known to undergo significant chemical reactions under typical usage scenarios.
Hazardous Decomposition Products: Upon strong heating, it may produce carbon monoxide, carbon dioxide, and other toxic gases.
Hazardous Polymerization: Will not occur.



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air.
If breathing difficulties persist, seek medical attention immediately.
Provide artificial respiration if the person is not breathing, and trained personnel should administer oxygen if necessary.


Skin Contact:

Remove contaminated clothing and immediately wash the affected skin area with plenty of soap and water for at least 15 minutes.
If irritation or redness occurs, seek medical advice.
Wash contaminated clothing thoroughly before reuse.


Eye Contact:

Flush the eyes gently with lukewarm water for at least 15 minutes, while keeping the eyelids open.
Seek immediate medical attention and ensure to provide information about the substance involved.


Ingestion:

Rinse the mouth thoroughly with water without swallowing.
Do not induce vomiting unless instructed to do so by medical professionals.
Seek medical attention immediately.
If vomiting occurs spontaneously and the person is conscious, place them in a recovery position to prevent choking.



HANDLING AND STORAGE


Handling:

Ensure adequate ventilation in the working area to maintain air quality and prevent the accumulation of vapors.
Use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and protective clothing to minimize skin and eye contact.
Avoid inhalation of vapors or mists.
If necessary, use respiratory protection equipment in accordance with occupational safety guidelines.

Handle the compound in a well-controlled and enclosed system to minimize the release of vapors into the environment.
Avoid eating, drinking, or smoking while handling the substance.
Wash hands thoroughly with soap and water after handling to remove any residual traces.


Storage:

Store N-hexyl glycol in tightly sealed containers made of compatible materials, such as high-density polyethylene (HDPE) or glass, to prevent leakage or evaporation.
Keep the containers in a cool, well-ventilated area away from direct sunlight, heat sources, sparks, and open flames.
Maintain appropriate temperature and humidity conditions to ensure the stability of the compound.
Store the substance separately from oxidizing agents, strong acids, and bases to prevent potential chemical reactions.

Label the storage containers clearly with the name of the substance and any relevant hazard warnings.
Store in a dedicated area or cabinet specifically designated for flammable or hazardous substances, following local regulations and guidelines.
Implement proper inventory management and control measures to ensure the correct storage and rotation of stock.
Regularly inspect the storage area for any signs of damage, leakage, or deterioration, and address any issues promptly.



SYNONYMS


Hexyl alcohol
Caproyl alcohol
1-Hexanol
Hexan-1-ol
Hexyl hydride
n-Hexyl alcohol
n-Hexanol
Alcohol C-6
Hexanol-1
Caproic alcohol
Hexyl carbinol
Hexan-1-ol
Hexanol
Hexyl hydrate
Caproic acid alcohol
n-Hexanol
n-Hexyl carbinol
Alcool hexylique
Alcohol hexilico
1-Hydroxyhexane
1-Caproyl alcohol
Caprylic alcohol
n-Hexyl alcohol
Hexylic alcohol
C6 alcohol
1-Hydroxyhexyl alcohol
Hexane-1-ol
n-Caproyl alcohol
Alcool hexylique
Hexanol-1
1-Hexyl alcohol
Alcool caproïque
Hexylalkohol
n-Hexan-1-ol
Hexylalkohol-1
n-C6H13OH
Hexyl hydroxide
Hexylol
Caproic alcohol
n-Hexanol
1-Hexyl hydride
Hexanol-1
Caproic hydride
Hexyl alcohol
Hexylic hydrate
Hexylic hydride
n-Hexyl hydride
Caprylic hydride
Caproyl hydride
1-C6 alcohol
Caproic hydride
1-Hydroxyhexyl hydride
n-Hexyl hydride alcohol
Hexyl alcohol-1
1-Hydroxyhexane-1
Alcool n-hexyl
Hexan-1-ol
Caproic acid hydride
Hexylalkohol-1
Hexylalkohol

N-Hexyl Glycol is an oily colorless liquid with a mild sweet odor.
N-Hexyl Glycol, also known as 1,6-Hexanediol, is a chemical compound with the molecular formula C6H14O2.
N-Hexyl Glycol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).

CAS Number: 107-41-5
Molecular Formula: C6H14O2
Molecular Weight: 118.17
EINECS Number: 203-489-0

N-Hexyl Glycol is a diol organic compound with a chiral carbon atom.
N-Hexyl Glycol is a colorless liquid at room temperature and can be Diacetone alcohol is hydrogenated.
The appearance is colorless liquid with mild sweetness.

N-Hexyl Glycol floats and mixes slowly with water.
N-Hexyl Glycol belongs to the class of diols, which are organic compounds containing two hydroxyl (-OH) groups.
The "n" in N-Hexyl Glycol indicates that the carbon chain is linear.

N-Hexyl Glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-Hexyl Glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-Hexyl Glycol's miscibility with water, however, is limited.

N-Hexyl Glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since N-Hexyl Glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2.6-di-tert-butyl-paracresol N-Hexyl Glycol is as a solvent for coatings and degreasing.
N-Hexyl Glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry.

The chemical structure of N-Hexyl Glycol consists of a hexane backbone (a six-carbon linear chain) with two hydroxyl groups (-OH) attached at each end.
N-Hexyl Glycol is a colorless liquid with a mild odor.
N-Hexyl Glycol is soluble in water and has various applications in different industries.

N-Hexyl Glycol is used in printing inks and cleaners.
N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
N-Hexyl Glycol has a low evaporation rate and it is completely miscible with water.

N-Hexyl Glycol is mainly used as a solvent or coupling agent. It is a potential substitute for glycol ethers.
N-Hexyl Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
N-Hexyl Glycol is often used in cosmetics and personal care products for its moisturizing properties.

N-Hexyl Glycol can contribute to the hydration of the skin when included in formulations such as creams and lotions.
In the flavor and fragrance industry, N-Hexyl Glycol can be utilized as a carrier for certain flavors and fragrances.
N-Hexyl Glycol is mild odor and solvency make it suitable for use in these applications.

N-Hexyl Glycol can be esterified with various acids to produce specific esters.
Esters derived from N-Hexyl Glycol may find use in different industries, including the fragrance and flavor industry.
N-Hexyl Glycol has been used historically in the production of photographic chemicals.

N-Hexyl Glycol is properties make it suitable for certain formulations in this industry.
N-Hexyl Glycol may be used in the formulation of metalworking fluids, where it can act as a lubricant and cooling agent during machining processes.
Due to its solvency, N-Hexyl Glycol can be incorporated into cleaning products, such as degreasers and industrial cleaners.

In the printing industry, N-Hexyl Glycol can be employed as a solvent and viscosity modifier in the formulation of printing inks.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
N-Hexyl Glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.

N-Hexyl Glycol is miscible with water, soluble in ethanol, and soluble in most organic solvents.
N-Hexyl Glycol is an oily colorless liquid with a mild sweet odor.
N-Hexyl Glycol floats and mixes slowly with water.

N-Hexyl Glycol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).
N-Hexyl Glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-Hexyl Glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.

N-Hexyl Glycol may be utilized in the formulation of hydraulic brake fluids. Its properties can contribute to the fluid's ability to transfer pressure and resist high temperatures in braking systems.
In the oil and gas industry, N-Hexyl Glycol might be used in the formulation of certain chemicals for oilfield applications, such as drilling fluids or completion fluids.
N-Hexyl Glycol can be employed in the formulation of coolants for various cooling systems, helping to maintain proper thermal conditions in industrial processes or automotive engines.

N-Hexyl Glycol may serve as a solvent in the pharmaceutical industry for certain drug formulations where its properties are beneficial.
N-Hexyl Glycol might be used as a catalyst or co-catalyst in organic synthesis reactions, facilitating specific chemical transformations.
In the field of hydraulic fracturing (fracking), N-Hexyl Glycol may find applications in the formulation of fracking fluids used to fracture rocks and extract natural gas or oil.

N-Hexyl Glycol can be incorporated into water treatment formulations for cooling towers to prevent scale formation and corrosion.
N-Hexyl Glycol's miscibility with water, however, is limited.
n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.

N-Hexyl Glycol may be explored in the development of electrolytes for fuel cells, contributing to the advancement of alternative energy technologies.
N-Hexyl Glycol can be used in the dyeing and textile industry, where it may assist in the solubilization and application of dyes.
N-Hexyl Glycol can serve as a carrier for certain catalysts in chemical reactions, contributing to the efficiency of the reaction process.

N-Hexyl Glycol, when incorporated into certain polymers, may contribute to the development of food packaging materials with specific properties, such as flexibility and durability.
N-Hexyl Glycol may be explored for potential applications in the production of materials used in photovoltaic devices, such as solar cells.
Since N-Hexyl Glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2.6-di-tert-butyl-paracresol.

N-Hexyl Glycol is as a solvent for coatings and degreasing.
N-Hexyl Glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry.
N-Hexyl Glycol is used in printing inks and cleaners.

N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
N-Hexyl Glycol has a low evaporation rate and it is completely miscible with water.
N-Hexyl Glycol is mainly used as a solvent or coupling agent. It is a potential substitute for glycol ethers.

N-Hexyl Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
N-Hexyl Glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.

Melting point: -40 °C (lit.)
Boiling point: 197 °C (lit.)
Density: 0.925 g/mL at 25 °C (lit.)
vapor density: 4.1 (vs air)
vapor pressure: 0.02 mm Hg ( 20 °C)
refractive index: n20/D 1.427(lit.)
Flash point: 201 °F
storage temp.: Store below +30°C.
solubility: H2O: 1 M at 20 °C, clear, colorless
form: Slightly Viscous Liquid
pka: 15.10±0.29(Predicted)
color: Clear
PH: 6-8 (25℃, 1M in H2O)
Odor: Ammonia-like.
explosive limit: 1-9.9%(V)
Water Solubility: soluble
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck: 14,4710
BRN: 1098298
Exposure limits ACGIH: TWA 25 ppm; STEL 50 ppm(10 mg/m3)
NIOSH: Ceiling 25 ppm(125 mg/m3)
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong reducing agents.
InChIKey: SVTBMSDMJJWYQN-UHFFFAOYSA-N
LogP: 0 at 20℃

Due to its ability to lower the freezing point of water, N-Hexyl Glycol may be used in the formulation of deicing fluids, particularly in applications where prevention of ice formation is crucial.
N-Hexyl Glycol can be employed as an additive in concrete formulations.
N-Hexyl Glycol may contribute to improved workability, setting time, or other properties of concrete.

In the automotive industry, N-Hexyl Glycol might be used as a component in fuel system additives, contributing to the stability and performance of the fuel.
N-Hexyl Glycol may find use in formulations of biocides or preservatives, helping to prevent the growth of microorganisms in various products, such as paints or personal care items.
N-Hexyl Glycol might be included in certain formulations of insect repellents, contributing to the overall effectiveness of the product.

In some extraction processes, N-Hexyl Glycol may be used as a solvent for the extraction of certain compounds from natural sources.
N-Hexyl Glycol is used as penetrant, emulsifier and antifreeze.
N-Hexyl Glycol is an oily colorless liquid with a mild sweet odor.

N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
N-Hexyl Glycol is used as a reagent in the synthesis of functionalized boronic esters.
N-Hexyl Glycol is used in laboratory studies as a precipitant and cryoprotectant in protein crystallography.

N-Hexyl Glycol may find applications in heat transfer fluids, helping to transfer heat efficiently in various industrial processes.
N-Hexyl Glycol may be used in analytical chemistry as a solvent or as a component in certain analytical methods.
N-Hexyl Glycol is a member of the glycol ether family, which includes various compounds used in different industries for their solvency, stability, and other properties.

N-Hexyl Glycol also used in the preparation of vinylboronates.
N-Hexyl Glycol is mainly used as a coupling agent and an additive to hydraulic fluids, inks and cement.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.

N-Hexyl Glycol is also employed as a blood volume expander.
N-Hexyl Glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.
N-Hexyl Glycol may be used in the tire manufacturing industry as a component in adhesives for tire cord, contributing to the bonding properties of the adhesive.

N-Hexyl Glycol may be employed as an antioxidant in fuel formulations to help prevent degradation and improve the stability of the fuel.
N-Hexyl Glycol might be considered as a component in wood preservatives, helping to protect wood from decay and insect damage.

In coatings and paint formulations, N-Hexyl Glycol could be used as an additive to modify certain properties of the coating, such as drying time or film formation.
N-Hexyl Glycol can be part of surfactant formulations where its properties contribute to the stability of emulsions or foams.

Preparation:
Using 2000 L of diacetone alcohol as a raw material to synthesize isohexanediol by hydrogenation reduction, the specific process steps are:Step 1: Start the vacuum pump to vacuum the raw material metering tank.
When the vacuum is greater than -0.06Mpa, close the exhaust valve, open the feed valve, mix 2000 L of diacetone alcohol raw material and 200ppm sodium bicarbonate and pump it in Raw material metering tank.
Step 2: Open the vacuum valve on the reduction pot and pump the reduction pot to a vacuum of -0.1Mpa, then open the feed valve on the reduction pot, and add 2000 L of diacetone alcohol raw material and 200ppm sodium bicarbonate from the metering tank To the reduction pot, start the mixer to stir at the same time, add 95Kg of Raney nickel catalyst.

Step 3: Close the vacuum valve, open the nitrogen inlet valve, and inject nitrogen into the reduction pot.
After the pressure in the pot is increased to 0.6Mpa within 3 to 5 minutes, close the hydrogen inlet valve, open the vent valve, and reduce the pressure in the pot.
Reduce to normal pressure, repeat the above steps, re-inject nitrogen for replacement, and repeat this five times.

Step 4: When the nitrogen replacement in the third step is completed, close the vent valve, open the hydrogen inlet valve, and inject hydrogen into the reduction pot within 10-15 minutes.
When the pressure in the pot reaches 0.6Mpa, close the hydrogen inlet valve.
Open the vent valve, after the pressure in the pot drops to normal pressure, close the vent valve, repeat the above steps, re-inject hydrogen for replacement, and repeat this five times.

Step 5: After the hydrogen replacement, close the vent valve, open the hydrogen gas inlet valve, and inject hydrogen into the reduction pot.
Use hydrogen to make the pressure in the pot reach 1.9Mpa within 15 to 30 minutes, then close the hydrogen gas inlet valve and open it.
Jacketed steam valve, raise the temperature in the pot to 150°C, and adjust the stirring speed to 310r/min.

At this time, open the hydrogen gas inlet valve and control the temperature in the pot at 150°C.
On the basis of the stable temperature in the pot, Keep the hydrogen vapor pressure at 1.9Mpa for 4 hours, then close the hydrogen gas inlet valve and accurately record the current pressure in the boiler.
After 30 minutes, take a sample for gas chromatographic testing.

If the raw material content is less than 1% in the test result, it is qualified.
At this time, Close the jacketed steam valve and open the jacketed cooling water to reduce the temperature in the pot to normal temperature.
Then, open the vent valve to reduce the pressure in the pot to normal pressure.

Step 6: Stop the mixer and let it stand for 50 minutes, close the vent valve, open the nitrogen inlet valve, use nitrogen to increase the pressure in the pot to 0.6Mpa, close the nitrogen valve, open the empty valve, and slowly reduce the pressure in the pot to normal pressure , And then repeat this step 5 times.
Step 7: Open the nitrogen valve and the feed valve of the distillation pot at the same time.
Use 0.8Mpa nitrogen to send the qualified materials to the filter for filtration.

The filtered materials are pumped into the crude isohexanediol storage tank, and then pressed to the distillation Distillation is carried out in the kettle, and the filtered catalyst is recycled; the finished product from the rectification is isohexanediol.
After the raw material of 2000 L diacetone alcohol is hydrogenated and reduced to synthesize, 1865Kg of isohexanediol product is obtained with a purity of 99.5%.

The mass yield is 99%. After cooling, it is placed in the isohexanediol product storage tank.
The remaining by-products are mainly 29kg of 98% acetone, which can be sold as industrial acetone.

Uses:
N-Hexyl Glycol is a fine chemical product with a wide range of uses, which can be used in pesticides, biochemical engineering, photosensitive materials, synthetic fragrances and other fields.
N-Hexyl Glycol is a highly soluble high-grade organic solvent.
N-Hexyl Glycol can be used as an additive in the production of metal surface treatment agents for rust and oil removal.

N-Hexyl Glycol can also be used as a textile auxiliaries, as well as coatings and latex paints.
N-Hexyl Glycol can also be used in cosmetics, as a pesticide stabilizer, but also as a daily chemical moisturizer, flavor and fragrance raw materials, hydraulic oil, high-temperature lubricating oil, brake oil, dry cleaning agent, printing ink, pigment dispersant, wood preservative etc.

N-Hexyl Glycol is used in skincare and hair care formulations for its moisturizing properties.
Included in creams, lotions, and shampoos.
Serves as a solvent in the production of paints and coatings.

Contributes to the viscosity and consistency of paint formulations.
Can contribute to the adhesive properties and work as a carrier for other components.
N-Hexyl Glycol is used in the synthesis of certain polymers.

Employed as a solvent in the formulation of printing inks.
Aids in the dispersion of pigments and other ink components.
Included as a component in fuel additives to improve stability and performance.

N-Hexyl Glycol is used in the dyeing and textile industry to solubilize and apply dyes.
Included in cleaning products such as degreasers and industrial cleaners.
N-Hexyl Glycol is used in the formulation of deicing fluids due to its ability to lower the freezing point of water.

Included as an additive in concrete formulations to improve workability and other properties.
N-Hexyl Glycol is used in formulations of biocides or preservatives to prevent the growth of microorganisms.
N-Hexyl Glycol is used in the formulation of hydraulic brake fluids and other automotive fluids.

Included in heat transfer fluids to aid in the transfer of heat in various industrial processes.
When incorporated into certain polymers, it can contribute to the development of food packaging materials.
Explored for potential applications in the development of electrolytes for fuel cells.

N-Hexyl Glycol is used as an additive in concrete formulations to improve workability and setting time.
Utilized in the oil and gas industry for the formulation of certain chemicals for oilfield applications.
N-Hexyl Glycol explored for potential applications in the production of materials used in photovoltaic devices.

N-Hexyl Glycol is used as a reagent in the synthesis of functionalized boronic esters.
N-Hexyl Glycol is used in laboratory studies as a precipitant and cryoprotectant in protein crystallography.
Also used in the preparation of vinylboronates.

N-Hexyl Glycol is mainly used as a coupling agent and an additive to hydraulic fluids, inks and cement.
Further, N-Hexyl Glycol is used as a solvent for cleaning and colorant products.
N-Hexyl Glycol is a potential substitute for glycol ethers.

N-Hexyl Glycol is an effective shrinkage reduction admixture or SRA for concrete and mortar.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
Hexylene glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.It is used to control the flow properties of industrial products such as paints, coatings, cleansers, solvents, and hydraulic fluids.

N-Hexyl Glycol acts as a thickening agent in cosmetic products.
N-Hexyl Glycol is also employed as a blood volume expander.
N-Hexyl Glycol is used to control the flow properties of industrial products such as paints, coatings, cleansers, solvents, and hydraulic fluids.

N-Hexyl Glycol acts as a thickening agent in cosmetic products.
N-Hexyl Glycol serves as a coupling agent and an additive to hydraulic fluids, inks and cement.
N-Hexyl Glycol is also employed as a blood volume expander.

Further, N-Hexyl Glycol is used as a solvent for cleaning and colorant products.
In addition to this, N-Hexyl Glycol is used in laboratory studies as a precipitant and cryoprotectant in protein crystallography.
N-Hexyl Glycol can also be used as a textile auxiliaries, as well as coatings and latex paints.

N-Hexyl Glycol can be used in the polymer industry as a component in the synthesis of certain polymers.
N-Hexyl Glycol may contribute to the properties of the resulting polymer, such as flexibility and durability.
Due to its solvency properties, N-Hexyl Glycol is utilized in the formulation of adhesives and sealants.

N-Hexyl Glycol can contribute to the adhesive properties and work as a carrier for other components.
In the production of inks, N-Hexyl Glycol can function as a solvent, aiding in the dispersion of pigments and other ink components.
N-Hexyl Glycol may be used in antifreeze formulations. Its ability to lower the freezing point of water makes it suitable for applications where protection against freezing is required.

In hydraulic fluids, N-Hexyl Glycol can be included to provide lubrication and to help maintain the fluidity of the hydraulic system.
N-Hexyl Glycol is commonly used in the paint and coatings industry as a solvent. Its solvency properties contribute to the formulation of coatings, providing proper viscosity and consistency.
N-Hexyl Glycol can serve as a building block or starting material in the synthesis of various chemicals in the laboratory or industrial processes.

In certain applications, N-Hexyl Glycol may be used as a component in fuel additives to improve fuel performance or characteristics.
N-Hexyl Glycol may find use in research and development activities, particularly in laboratories exploring new formulations, materials, or chemical processes.
In some cases, N-Hexyl Glycol may be employed in the production of surfactants, which are compounds that can lower the surface tension between two phases (e.g., between a liquid and a solid).

N-Hexyl Glycol can also be used in cosmetics, as a pesticide stabilizer, but also as a daily chemical moisturizer, flavor and fragrance raw materials, hydraulic oil, high-temperature lubricating oil, brake oil, dry cleaning agent, printing ink, pigment dispersant, wood preservative etc.
N-Hexyl Glycol is used in printing inks and cleaners.
N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.

N-Hexyl Glycol is used as a solvent in various applications, including coatings, paints, and inks.
N-Hexyl Glycol is employed in the formulation of cosmetics and personal care products, such as skin creams and lotions.
N-Hexyl Glycol can serve as an intermediate in the synthesis of other chemicals.

N-Hexyl Glycol may be used as a plasticizer in the production of plastics.
N-Hexyl Glycol is hygroscopic, meaning it has a tendency to absorb moisture from the air.
N-Hexyl Glycol is considered to be biodegradable, which means it can be broken down by natural processes over time.

N-Hexyl Glycol is mainly used as a solvent or coupling agent.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
N-Hexyl Glycol is used as a carrier for certain catalysts in chemical reactions, aiding in the efficiency of the reaction process.

Included as a component in fuel system additives, contributing to the stability and performance of the fuel.
Employed in analytical chemistry as a solvent or as a component in certain analytical methods.
N-Hexyl Glycol is part of the glycol ether family, which includes various compounds used in different industries for their solvency, stability, and other properties.

N-Hexyl Glycol is used in the formulation of deicing fluids to prevent ice formation on surfaces.
Included as a component in wood preservatives, helping protect wood from decay and insect damage.
Incorporated into water treatment formulations for cooling towers to prevent scale formation and corrosion.

Historically used in the production of photographic chemicals for its specific properties.
N-Hexyl Glycol is utilized in the formulation of metalworking fluids, providing lubrication and cooling during machining processes.
N-Hexyl Glycol is used as a carrier for certain flavors and fragrances due to its mild odor and solvency.

Included in certain food products for its solubility and other functional properties.
N-Hexyl Glycol is used in the tire manufacturing industry as a component in adhesives for tire cord, contributing to bonding properties.
Employed in the formulation of coolants for various cooling systems, helping to maintain proper thermal conditions.

Part of surfactant formulations where its properties contribute to the stability of emulsions or foams.
May find applications in hydraulic fracturing fluids used in oil and gas extraction processes.
Included as an antioxidant in fuel formulations to prevent degradation and improve stability.

Safety Profile:
N-Hexyl Glycol may cause irritation to the skin and eyes upon contact.
N-Hexyl Glycol's important to use appropriate personal protective equipment, such as gloves and safety goggles, when handling this substance.

Inhalation of vapors or mists of N-Hexyl Glycol may cause respiratory irritation.
Ensure adequate ventilation in areas where N-Hexyl Glycol is used and consider using respiratory protection if needed.
Ingesting N-Hexyl Glycol can be harmful.

N-Hexyl Glycol is not intended for consumption, and ingestion may lead to adverse health effects.
N-Hexyl Glycol is hygroscopic, meaning it can absorb moisture from the air.
This property can lead to changes in the physical characteristics of the substance and may affect its handling properties.

While N-Hexyl Glycol itself is not highly flammable, it may still pose a fire hazard under certain conditions.
Take appropriate precautions to prevent ignition sources in areas where it is handled.

Synonyms:
Hexylene glycol
2-METHYL-2,4-PENTANEDIOL
107-41-5
2-Methylpentane-2,4-diol
Diolane
Pinakon
2,4-Pentanediol, 2-methyl-
2,4-Dihydroxy-2-methylpentane
Isol
4-Methyl-2,4-pentanediol
1,1,3-Trimethyltrimethylenediol
Caswell No. 574
2-Methyl pentane-2,4-diol
2-Methyl-2,4-pentandiol
hexyleneglycol
HSDB 1126
UNII-KEH0A3F75J
(+-)-2-Methyl-2,4-pentanediol
NSC 8098
NSC-8098
EINECS 203-489-0
KEH0A3F75J
alpha,alpha,alpha'-Trimethyltrimethylene glycol
EPA Pesticide Chemical Code 068601
BRN 1098298
1,3-dimethyl-3-hydroxybutanol
CCRIS 9439
DTXSID5021885
CHEBI:62995
AI3-00919
Hexylene glycol [NF]
1,3,3-trimethyl-1,3-propanediol
TRACID RUBINE 5BL
DTXCID101885
EC 203-489-0
1,1,3-trimethyl-1,3-propanediol
4-01-00-02565 (Beilstein Handbook Reference)
MFCD00004547
Hexylene glycol (NF)
HEXYLENE GLYCOL (II)
HEXYLENE GLYCOL [II]
7-MethylAtracuriumDimesylate(MixtureofDiastereomers)
MPD
HEXYLENE GLYCOL (MART.)
HEXYLENE GLYCOL [MART.]
HEXYLENE GLYCOL (USP-RS)
HEXYLENE GLYCOL [USP-RS]
CAS-107-41-5
2-Methylpentan-2,4-diol
2-Methyl-pentane-2,4-diol
64229-01-2
Hexylene glycol, 99%
R-(-)-2-METHYL-2,4-PENTANEDIOL
2methyl-2,4-pentanediol
2-methyl-2-4-pentanediol
Hexylene glycol, >=99%
Hexylene glycol, 99.5%
SCHEMBL19379
HEXYLENE GLYCOL [MI]
1,3-Trimethyltrimethylenediol
HEXYLENE GLYCOL [HSDB]
HEXYLENE GLYCOL [INCI]
CHEMBL2104293
NSC8098
(?)-2-Methyl-2,4-pentanediol
SVTBMSDMJJWYQN-UHFFFAOYSA-N
HMS3264E19
HY-B0903
Hexylene glycol, analytical standard
Tox21_201975
Tox21_302818
(+/-)-2-Methyl-2,4-pentanediol
s3588
AKOS015901459
CCG-213719
WLN: QY1 & 1XQ1 & 1
NCGC00249143-01
NCGC00256494-01
NCGC00259524-01
(+/-)-2,4-Dihydroxy-2-methyl pentane
AC-13749
AS-58339
Hexylene glycol, BioXtra, >=99% (GC)
(+/-)-2-Methyl-2,4-pentanediol, MPD
FT-0605050
FT-0605756
FT-0613069
Hexylene glycol, puriss., >=99.0% (GC)
M0384
(S)-(-)-2-METHYL-2,4-PENTANEDIOL
.alpha.,.alpha.'-Trimethyltrimethylene glycol
Hexylene glycol, BioUltra, >=99.0% (GC)
D04439
EN300-170052
AB01563179_01
J-640306
J-660006
Q2792203
W-108748
Z1255485267
Hexylene glycol, United States Pharmacopeia (USP) Reference Standard

N-Hexyl glycol, also known as N-hexyl glycol (Hexyl cellosolve solvent), is a chemical compound that falls into the class of glycol ethers.
Its chemical structure consists of a hexyl group (a six-carbon alkyl chain) attached to a glycol ether functional group.
The systematic name for N-hexyl glycol (Hexyl cellosolve solvent) is 2-(2-Hexyloxyethoxy)ethanol.

CAS Number: 112-25-4
EC Number: 203-951-1

Hexyl Cellosolve Solvent, 2-(2-Hexyloxyethoxy)ethanol, N-Hexyl glycol, Hexyl cellosolve, Hexyl ethylene glycol, 2-Hexyloxyethanol, 2-(2-Hexyloxyethoxy)ethanol, Hexyl glycol ether, Hexyl oxitol, Hexyl 2-(2-hexyloxyethoxy)ethyl ether, Hexyl 2-(2-hexyloxyethoxy)ethanol, Hexyl 2-(2-hexyloxyethoxy)ethyl alcohol, Hexyl 2-(2-hexyloxyethoxy)ethoxyethanol, 2-Hexyloxyethyl ether, 2-Hexyl oxyethanol, Hexyl oxitol solvent, Hexyl 2-(2-hexyloxyethoxy)ethyl, Hexyl 2-(2-hexyloxyethoxy)ethyl ester



APPLICATIONS


N-hexyl glycol (Hexyl cellosolve solvent) is extensively used in the formulation of paints and coatings, where it contributes to pigment dispersion and film formation.
In the printing ink industry, N-hexyl glycol (Hexyl cellosolve solvent) is a valuable component, enhancing stability and consistency in ink formulations.
Its solvency properties make it a preferred choice in the creation of cleaning solutions for industrial and household applications.
N-hexyl glycol (Hexyl cellosolve solvent) serves as a degreasing agent, effectively removing oily substances and contaminants from surfaces.

N-hexyl glycol (Hexyl cellosolve solvent) finds application in the electronics industry for formulating cleaning solutions used on delicate electronic components and circuit boards.
In the adhesive and sealant industry, it enhances the performance of formulations, acting as a plasticizer and modifier.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in varnishes, contributing to their application properties and durability.
N-hexyl glycol (Hexyl cellosolve solvent) acts as a coalescing agent in paint formulations, ensuring uniform film formation and improved coating characteristics.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the production of rust removers, aiding in the removal of rust and corrosion from metal surfaces.
In hydraulic fluids, Hexyl Cellosolve Solvent contributes to lubricating properties, enhancing the efficiency of hydraulic systems.
Metalworking fluids benefit from its inclusion, providing cooling and lubrication during machining processes.

N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the formulation of conveyor belt lubricants, ensuring smooth operation and longevity of belts.
Its compatibility with elastomers makes it valuable in the formulation of rubber products with specific performance requirements.

Automotive refinishing applications benefit from its use in paint formulations, contributing to high-quality and durable coatings.
N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into specialty cleaning products used for the maintenance and cleaning of machinery and equipment.
Its mild odor makes it suitable for formulations where minimal or no fragrance is desired, such as certain cleaning products.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of environmentally friendly industrial products, aligning with sustainable practices.

The textile industry utilizes N-hexyl glycol (Hexyl cellosolve solvent) in dyeing processes, aiding in the dispersion and fixation of dyes on fabrics.
N-hexyl glycol (Hexyl cellosolve solvent) plays a role in the creation of transparent coatings, providing visual clarity and colorless properties.

In the production of lubricity improvers, it enhances the lubricating properties of various formulations.
Certain specialty applications benefit from derivatives of Hexyl Cellosolve Solvent, tailored to achieve specific industrial needs.
N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of water-based and solvent-based products, showcasing its versatility.

Its application in the creation of ink removers highlights its efficiency in cleaning solutions for printing equipment.
N-hexyl glycol (Hexyl cellosolve solvent) is used in the formulation of household cleaning products, contributing to their effectiveness in removing stains and dirt.
N-hexyl glycol (Hexyl cellosolve solvent) serves as a valuable component in the creation of high-performance industrial products across diverse sectors.

N-hexyl glycol (Hexyl cellosolve solvent) is a key ingredient in the formulation of wood finishes and stains, providing effective penetration and enhancing the color of wood surfaces.
Its use in certain pesticide formulations as a co-solvent improves the dispersion and effectiveness of active ingredients.

N-hexyl glycol (Hexyl cellosolve solvent)'s compatibility with resins makes it essential in the production of adhesive formulations, ensuring strong and durable bonds.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the creation of specialty industrial and institutional cleaners, offering effective removal of contaminants.

In the leather industry, it is utilized in the formulation of leather finishing products, contributing to texture and appearance.
The versatility of this glycol ether extends to the formulation of certain personal care products, such as hand sanitizers and skin creams.
N-hexyl glycol (Hexyl cellosolve solvent) is used in the creation of ink formulations for various writing instruments, ensuring smooth and consistent flow.
Its inclusion in certain hydraulic fluids enhances their lubricity, promoting efficient operation in hydraulic systems.

N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of metalworking fluids, providing cooling and lubrication during machining and cutting processes.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of conveyor belt lubricants, ensuring the smooth operation of belts in industrial settings.
N-hexyl glycol (Hexyl cellosolve solvent) plays a crucial role in the formulation of rust inhibitors, protecting metal surfaces from corrosion in various applications.
Hexyl Cellosolve Solvent is used in the creation of degassing agents, enhancing their efficiency in removing air bubbles from formulations.

In the creation of inkjet printer inks, its solvency properties aid in the dispersion of color pigments for high-quality printing.
N-hexyl glycol (Hexyl cellosolve solvent) is applied in the production of defoamers, helping to control foam formation in various industrial processes.
N-hexyl glycol (Hexyl cellosolve solvent) finds utility in the formulation of cooling tower water treatment chemicals, preventing scale and corrosion.
Its use in the creation of brake fluids contributes to the fluid's stability and performance in automotive braking systems.

N-hexyl glycol (Hexyl cellosolve solvent) is employed in the formulation of certain wood preservatives, protecting wood from decay and insect damage.
N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the production of certain sealants, ensuring proper adhesion and sealing properties.
In the creation of cutting fluids used in metal machining, it aids in cooling and lubricating the cutting tool and workpiece.

N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain fuel additives, enhancing fuel stability and combustion efficiency.
N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of certain paint strippers, facilitating the removal of old paint and coatings.
Its inclusion in certain household and industrial detergents enhances their cleaning efficiency on various surfaces.
In the creation of polymer dispersions, it aids in the stabilization and dispersion of polymer particles in water-based formulations.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the formulation of certain floor polishes, providing gloss and protection to flooring surfaces.
N-hexyl glycol (Hexyl cellosolve solvent) is applied in the production of certain drilling fluids, contributing to the lubrication and stability of the drilling process.

N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the formulation of specialty inks for flexographic and gravure printing, ensuring precise and consistent printing on various substrates.
Its compatibility with epoxy resins makes it valuable in the production of epoxy-based adhesives, providing strong and durable bonds.

In the electronics industry, it is incorporated into the formulation of solder fluxes, aiding in the soldering process by reducing oxidation.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the creation of paint removers, facilitating the stripping of old paint and coatings from surfaces.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the production of certain agricultural formulations, contributing to the effectiveness of herbicides and insecticides.
In the cosmetics industry, it is found in the formulation of certain makeup and skincare products, acting as a solubilizer and stabilizer.

N-hexyl glycol (Hexyl cellosolve solvent) is applied in the creation of fuel system cleaners, helping to remove deposits and improve engine performance.
Its use in the formulation of cutting-edge nanomaterials and nanoparticles showcases its versatility in advanced materials science.

N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain pharmaceutical formulations, aiding in the solubility of active ingredients for medicinal applications.
N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of mold release agents, ensuring easy release of molded products from molds.

In the production of specialty coatings for optical lenses, it aids in achieving anti-reflective and scratch-resistant properties.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the creation of ink formulations for digital printing, delivering high-quality prints with vibrant colors and clarity.
N-hexyl glycol (Hexyl cellosolve solvent) is used in the production of certain insect repellents, enhancing the dispersion of active repellent ingredients.
In the creation of automotive windshield washer fluids, it contributes to the formulation's ability to effectively clean and remove debris.

N-hexyl glycol (Hexyl cellosolve solvent) is applied in the production of certain photographic chemicals, aiding in the development and processing of photographs.
N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the creation of air fresheners, contributing to the dispersion of fragrances in various formulations.
Its use in the formulation of specialty coatings for electronic displays helps achieve anti-glare and anti-scratch properties.
N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain leather conditioners, contributing to softness and protection of leather surfaces.

N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of certain anti-fogging agents, enhancing visibility on surfaces prone to fogging.
In the formulation of certain resin-based dental materials, it aids in achieving proper consistency and handling properties.
N-hexyl glycol (Hexyl cellosolve solvent) is applied in the creation of specialty lubricants, providing effective lubrication in precision machinery and equipment.

N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of certain heat transfer fluids, enhancing the efficiency of heat exchange systems.
In the creation of industrial floor coatings, it helps achieve durable and chemically resistant finishes for high-traffic areas.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the formulation of certain wood coatings, contributing to protection against UV radiation and weathering.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of certain sealant primers, ensuring proper adhesion to various substrates.



DESCRIPTION


N-Hexyl glycol, also known as N-hexyl glycol (Hexyl cellosolve solvent), is a chemical compound that falls into the class of glycol ethers.
Its chemical structure consists of a hexyl group (a six-carbon alkyl chain) attached to a glycol ether functional group.
The systematic name for N-hexyl glycol (Hexyl cellosolve solvent) is 2-(2-Hexyloxyethoxy)ethanol.

N-Hexyl glycol, commonly known as Hexyl Cellosolve Solvent, is a clear and colorless liquid with a mild, characteristic odor.
N-hexyl glycol (Hexyl cellosolve solvent) is valued for its versatile solvency, making it a preferred choice in various industrial formulations.
N-hexyl glycol (Hexyl cellosolve solvent) is an organic compound featuring a hexyl group attached to a glycol ether functional group.

With its clear appearance, it is often utilized in applications where visual clarity is essential, such as in transparent coatings.
As a solvent, N-hexyl glycol (Hexyl cellosolve solvent) exhibits excellent dissolving properties, allowing it to dissolve a wide range of substances effectively.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the formulation of paints, coatings, and inks, where it aids in pigment dispersion and film formation.

Its molecular structure, with a hexyl chain, contributes to its balance between hydrophobic and hydrophilic characteristics.
N-hexyl glycol (Hexyl cellosolve solvent)'s solvency extends to cleaning products, making it an efficient degreasing agent with industrial and household applications.
N-hexyl glycol (Hexyl cellosolve solvent) is known for its compatibility with various materials, enhancing its versatility in different formulations.

In certain specialty applications, derivatives of this glycol ether are used to achieve specific properties tailored to unique industrial needs.
N-hexyl glycol (Hexyl cellosolve solvent) serves as a plasticizer and modifier in certain formulations, contributing to flexibility and improved characteristics.

Due to its chemical properties, Hexyl Cellosolve Solvent acts as a coalescing agent in paint formulations, ensuring a uniform film.
In the electronics industry, it is employed in the creation of cleaning solutions for delicate electronic components and circuit boards.
N-hexyl glycol (Hexyl cellosolve solvent) finds application in the production of adhesives, sealants, and varnishes, enhancing their performance.

Its mild odor is advantageous in formulations where minimal or no fragrance is desired, such as certain cleaning products.
N-hexyl glycol (Hexyl cellosolve solvent)'s effectiveness as a degreasing agent makes it suitable for applications where the removal of oily substances is crucial.
Hexyl Cellosolve Solvent exhibits a balanced evaporation rate, contributing to its utility in various coating and cleaning formulations.

As a hexyl ether, N-hexyl glycol (Hexyl cellosolve solvent) demonstrates a blend of properties that make it versatile in both water-based and solvent-based formulations.
Its use in the formulation of rust removers highlights its effectiveness in removing rust and corrosion from metal surfaces.
In the textile industry, Hexyl Cellosolve Solvent is utilized in dyeing processes, aiding in the dispersion and fixation of dyes on fabrics.

N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain hydraulic fluids and metalworking fluids, contributing to their lubricating properties.
Hexyl Cellosolve Solvent plays a role in automotive refinishing applications, contributing to the formulation of high-quality coatings.

Its compatibility with elastomers makes it valuable in the formulation of rubber products with specific performance requirements.
N-hexyl glycol (Hexyl cellosolve solvent) continues to be a key ingredient in the development of environmentally friendly and high-performance industrial products.
N-hexyl glycol (Hexyl cellosolve solvent)'s solvency properties make it indispensable in the formulation of inks, coatings, and cleaning solutions across diverse industries.



PROPERTIES


Boiling Point (°C @760mmHg): 208
Chemical Name: Ethylene glycol mono hexyl ether
Density (25°C) at lb/gal (g/cc): 7.37 (0.883)
Evaporation Rate (n-butyl acetate=1.0): 0.0082
Flash Point, Closed Cup: 99 °C
Freezing Point °F(°C): -58 (-50)
Hansen Solubility Parameter, dD (joules/cm3)1/2: 16
Hansen Solubility Parameter, dH (joules/cm3)1/2: 10.9
Hansen Solubility Parameter, dP (joules/cm3)1/2: 6.9
Molecular Weight: 146.2 g/mol
Solubility in Water (25°C): 0.88 wt%
Solubility Water in (25°C): 17.7 wt%
Specific Gravity (25°C): 0.866
Surface Tension (1% actives, 25 °C): 27.7 dynes/cm
Vapor Pressure (mmHg @ 20°C): 0.038
Viscosity (25°C): 4.5 cP



FIRST AID


Inhalation:

If inhaled, move the person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
Administer artificial respiration if the person is not breathing.


Skin Contact:

Remove contaminated clothing and footwear.
Wash the affected area thoroughly with soap and water.
If irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.


Eye Contact:

Flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.


Ingestion:

Do not induce vomiting unless directed to do so by medical personnel.
Rinse mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.


Note to Physicians:

Treat symptomatically.
No specific antidote.
Provide supportive care.


General Advice:

Consult a physician if necessary.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Keep the affected person warm and at rest.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of vapors.
Do not eat, drink, or smoke while handling the substance.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent evaporation and contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating aerosols or mists.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where vapors may be present.


Storage:

Temperature:
Store at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.

N-HEXYLGLYCOL = HEXYL GLYCOL = ETHYLENE GLYCOL MONOHEXYL ETHER = 2-(HEXYLOXY)ETHANOL


CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2 / C6H13OCH2CH2OH


n-Hexylglycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.
Two solvents, n-Hexylglycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
n-Hexylglycol's vapour is heavier than air.


n-Hexylglycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
n-Hexylglycol is a glycol ether that has a chemical formula of C8H18O2.
n-Hexylglycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor
n-Hexylglycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.


Since n-Hexylglycol may react with the oxygen in the air to form peroxides.
n-Hexylglycol is a colorless liquid with a slight ether odor and bitter taste.
n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
n-Hexylglycol's miscibility with water, however, is limited.



USES and APPLICATIONS of N-HEXYLGLYCOL:
n-Hexylglycol is used high-boiling solvent.
n-Hexylglycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
n-Hexylglycol is used as a coalescing agent in latex paints and cleaners.
n-Hexylglycol can be used as coalescent for water-borne.


n-Hexylglycol is used as special solvent for coating and ink.
n-Hexylglycol can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
n-Hexylglycol can be used as primary solvent in solvent-based silk screen printing inks.


n-Hexylglycol can be used as primary solvent in solvent-based silk screen printing inks.
n-Hexylglycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
n-Hexylglycol is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.


n-Hexylglycol is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products.
n-Hexylglycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
n-Hexylglycol is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.


n-Hexylglycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
n-Hexylglycol improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, n-Hexylglycol greatly improves film formation and levelling.
n-Hexylglycol can be used as coalescent for water-borne.


n-Hexylglycol can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
n-Hexylglycol can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
Other uses of n-Hexylglycol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties,


n-Hexylglycol is used Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.
Usage of n-Hexylglycol: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.
n-Hexylglycol can be used as solvent in specialty printing inks.


n-Hexylglycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.
n-Hexylglycol can also be used in printing inks and cleaners.
n-Hexylglycol series are mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.


n-Hexylglycol has excellent oil solubility, making it effective in household and industrial cleaning applications.
n-Hexylglycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
n-Hexylglycol has excellent oil solubility, making it effective in household and industrial cleaning applications.
n-Hexylglycol is used Industry, Scientific Research, Health, Environmental Protection, Agriculture


n-Hexylglycol can be used as solvent in specialty printing inks.
n-Hexylglycol is used as a high-boiling solvent.
n-Hexylglycol is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
n-Hexylglycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.


Two solvents, n-Hexylglycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
n-Hexylglycol serves as a coalescing agent in cleaners and latex paints.
n-Hexylglycol is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.



ALTERNATIVE PARENTS of N-HEXYLGLYCOL:
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS of N-HEXYLGLYCOL:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of N-HEXYLGLYCOL:
Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1
Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Ų
Rotatable Bond Count: 7

Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -



FIRST AID MEASURES of N-HEXYLGLYCOL:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-HEXYLGLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.

FIRE FIGHTING MEASURES of N-HEXYLGLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-HEXYLGLYCOL:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.


HANDLING and STORAGE of N-HEXYLGLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.


STABILITY and REACTIVITY of N-HEXYLGLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available

SYNONYMS:
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
2-(Hexyloxy)ethanol
3-Oxa-1-nonanol
Ethanol, 2-(hexyloxy)- (6CI, 7CI, 8CI, 9CI)
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Glycol monohexyl ether
Hexyl CELLOSOLVE™ Solvent
Hexyl cellosolve
n-Hexyl Cellosolve
n-Hexylglykol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether

NIACINAMIDE; 3-Pyridinecarboxamide; Nicotinamide; Propamine A; Niacinamide; -Pyridinecarboxamide; Nicosylamide; Nicotamide; Nicotilamide; Nicotine acid amide; Nicotinic acid amide; Nicotinic amide; Nicotylamide; Nicovit; Nicovitina; Nikotinamid; Niocinamide; 3-Carbamoyl-pyridine; Vitamin B; Vitamin B3; 3-Carbamoylpyridine; 3-Pyridinecarboxylic acid amide; Picolinamide; Niamide; cas no: 98-92-0

Niacin (Vitamin B3) is slightly soluble in water and ethanol; nicotinamide is very soluble in water and moderately soluble in ethanol.
Niacin (Vitamin B3) deficiency is also associated with perosis in chickens as well as poor feathering of the birds.
Niacin (Vitamin B3) and nicotinamide are colorless crystalline substances.

CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
EINECS Number: 200-441-0

Niacin (Vitamin B3) can produce a variety of adverse effects, depending on the intake and health of the consumer.
Niacin (Vitamin B3) is frequently identified with the B complex vitamin grouping.
Early in the research on niacin, a nutritional niacin deficiency was identified as the cause of pellagra in humans, blacktongue in dogs, and certain forms of dermatosis in humans.

Niacin (Vitamin B3), Niacin or B3 is a water-soluble vitamin.
Derivatives of NADH, NADPH, NAD and NAD+ are a vitamin that has been affected in terms of energy, nuclear acids, protein fats and production.
Niacin (Vitamin B3) cannot be included in the term vitamin B3.

Niacin (Vitamin B3)s car boxyl group can form esters and anhydrides and can be reduced.
Both Niacin (Vitamin B3) and nicotinamide are very stable in dry form, but in solution nicotinamide is hydro lyzed by acids and bases to yield nicotinic.
The coenzyme forms of niacin are the pyridine nucleotides, NAD(H) and NADP(H).

The skin flushing reaction produced by Niacin (Vitamin B3) has been recognized for more than 70 years.
Niacin (Vitamin B3), melting point is 234-237℃.
In each of these compounds, the electron-withdrawing effect of the N-1 atom and the amide group of the oxidized pyridine nucleus enables the pyridine C-4 atom to react with many nucleophilic agents (e.g., sulfite, cyanide, and hydride ions).

Niacin (Vitamin B3) is the reaction with hydride ions (H?) that is the basis of the enzymatic hydrogen transfer by the pyridine nucleotides; the reaction involves the transfer of two electrons in a single step.
Several substituted pyridines are antagonists of niacin in biological systems: pyridine-3-sulfonic acid, 3-acetylpyridine, isoNiacin (Vitamin B3) hydrazine, 17 and 6-aminonicotinamide.
Niacin (Vitamin B3) is slightly soluble in water and ethanol; 100ml room temperature water can dissolve 1.6g.

When taken on an empty stomach, crystalline Niacin (Vitamin B3) in doses as small as 10 mg may produce a mild and transient, but noticeable, flushing reaction.
While not desirable, such reactions produce no known adverse consequences, and they are almost never perceptible when small amounts of Niacin (Vitamin B3) are taken in tablet or capsule form or consumed as part of food.
Niacin (Vitamin B3) was discovered by the oxidation of nicotine.

Niacin (Vitamin B3) is derived from Niacin (Vitamin B3) + vitamin, as the name to be given to it is not intended to evoke nicotine.
Niacin (Vitamin B3) can be seen in ancient texts that the name vitamin PP (short for the English term "pellegra prevention") was used for Niacin (Vitamin B3).
Niacin (Vitamin B3) is a B vitamin that's made and used by your body to turn food into energy.

Niacin (Vitamin B3) helps keep nervous system, digestive system and skin healthy.
Niacin (Vitamin B3) (vitamin B-3) is often part of a daily multivitamin, but most people get enough niacin from the food they eat.
Niacin (Vitamin B3) is sometimes referred to as Niacin (Vitamin B3) or nicotinamide and earlier called the P-P factor, antipellagra factor, antiblacktongue factor, and vitamin B4, niacin is available in several forms (niacin, niacinamide, niacinamide ascorbate, etc.) for use as a nutrient and dietary supplement.

Niacin (Vitamin B3), also known as niacin or vitamin B3, is a white crystal or crystalline powder, odorless or has a slight odor, slight sour taste.
Niacin (Vitamin B3) is easily soluble in hot water, hot ethanol, alkaline water, propylene glycol, and chloroform.
Niacin (Vitamin B3), or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.

The two most common forms of Niacin (Vitamin B3) in food and supplements are Niacin (Vitamin B3) and nicotinamide.
The body can also convert tryptophan—an amino acid—to nicotinamide.
Niacin (Vitamin B3) is water-soluble so that excess amounts the body does not need are excreted in the urine.

Niacin (Vitamin B3) works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Niacin (Vitamin B3) helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Niacin, also known as Niacin (Vitamin B3), is an organic compound and a vitamer of vitamin B3, an essential human nutrient.

Niacin (Vitamin B3) can be manufactured by plants and animals from the amino acid tryptophan.
Niacin (Vitamin B3) as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness.

Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide derivative Niacin (Vitamin B3) (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Although Niacin (Vitamin B3) and nicotinamide are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, it does not reduce cholesterol nor cause flushing.

Niacin (Vitamin B3) is recommended as a treatment for niacin deficiency because it can be administered in remedial amounts without causing the flushing, considered an adverse effect.
Niacin (Vitamin B3) (also known as vitamin B3) is one of the water-soluble B vitamins.
Niacin (Vitamin B3) is naturally present in many foods, added to some food products, and available as a dietary supplement.

Niacin (Vitamin B3) is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Niacin (Vitamin B3) has a role as an antidote, an antilipemic drug, a vasodilator agent, a metabolite, an EC 3.5.1.19 (nicotinamidase) inhibitor, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a plant metabolite.
Niacin (Vitamin B3) is a vitamin B3, a pyridinemonocarboxylic acid and a pyridine alkaloid.

Niacin (Vitamin B3) is a conjugate acid of a nicotinate.
Niacin (Vitamin B3), or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.
The two most common forms of Niacin (Vitamin B3) in food and supplements are Niacin (Vitamin B3) and nicotinamide.

The body can also convert tryptophan—an amino acid—to nicotinamide.
Niacin (Vitamin B3) is water-soluble so that excess amounts the body does not need are excreted in the urine.
Niacin (Vitamin B3) works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.

Niacin (Vitamin B3) helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Niacin (Vitamin B3) is also a prescription medication.
Niacin (Vitamin B3) is the generic name for Niacin (Vitamin B3) (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside.

Niacin (Vitamin B3) is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.
Niacin (Vitamin B3), on the other hand, is quite scarce in food and only recently started being sold as a supplement.
All three forms of vitamin B3 are converted to an important coenzyme called Niacin (Vitamin B3) in the body.

While not dangerous, Niacin (Vitamin B3) can be uncomfortable, or even alarming, if you aren’t prepared for it.
Niacin (Vitamin B3), also known as vitamin B3, is a water-soluble vitamin.
Water-soluble vitamins are stored in the body in very limited amounts and are excreted through the urine.

The Niacin (Vitamin B3) filter solutions are filled and immediately fused under controlled conditions to become permanently airtight.
Niacin (Vitamin B3) (NYE a sin) is used in combination with a healthy diet to lower bad cholesterol and increase good cholesterol.
Niacin (Vitamin B3) is also used to decrease triglycerides.

Niacin (Vitamin B3) can also be helpful in patients who have heart disease or who have had a heart attack.
Niacin (Vitamin B3) may be used for other purposes; ask your health care provider or pharmacist if you have questions.
Niacin (Vitamin B3) (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (Niacin (Vitamin B3) and nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

The two coenzymes are required for oxidative reactions crucial for energy production, but they are also substrates for enzymes involved in non-redox signaling pathways, thus regulating biological functions, including gene expression, cell cycle progression, DNA repair and cell death.
Therefore, Niacin (Vitamin B3) is a good idea to have them in your daily diet.
In addition to getting Niacin (Vitamin B3) from dietary sources, the body can synthesize a form of niacin from the amino acid tryptophan.

Niacin (Vitamin B3) causes the blood vessels to dilate or open up near the skin, which results in a hot, tingling sensation accompanied by a red flushing of the skin.
Generally, by starting with low amounts of Niacin (Vitamin B3) (50 to 100 mg a day) and gradually increasing the dosage, a person can quickly build up a tolerance and avoid the flush.
Taking Niacin (Vitamin B3) immediately following a meal will also lessen the flushing sensation.

Since Niacin (Vitamin B3) isn’t something that drug companies can patent, it’s of little interest to them.
Niacin (Vitamin B3), 3-pyridinecarboxylicacid (Niacin), is effective in the treatment of all types ofhyperlipoproteinemia except type I, at doses above thosegiven as a vitamin supplement.
Niacin (Vitamin B3) reduces VLDLsynthesis and, subsequently, its plasma products, IDL andLDL.

Plasma triglyceride levels are reduced because of thedecreased VLDL production.
Niacin (Vitamin B3) is found in all living cells, and it plays a vital role in energy metabolism and maintaining proper cell functioning — particularly the functioning of our mitochondria, the power plants in our cells that turn food and oxygen into energy.

Niacin (Vitamin B3) also plays an important role in protecting cells all over the body from age-related damage and decline in function.
While all three forms of vitamin B3 share common traits, each has a slightly different effect on the body and serves a different role when taken as a supplement.
Niacin (Vitamin B3) (or Niacin (Vitamin B3) as it’s referred to in medical circles) was the third B vitamin to be discovered (hence the name B3).

Melting point: 236-239 °C(lit.)
Boiling point: 260C
Density: 1.473
refractive index: 1.5423 (estimate)
Flash point: 193°C
storage temp.: 2-8°C
solubility: 18g/l
pka: 4.85(at 25℃)
form: Powder
color: White to off-white
PH: 2.7 (18g/l, H2O, 20℃)
Odor: odorless to sl. odor, sour taste
Water Solubility: 1-5 g/100 mL at 17 ºC
Merck: 14,6525
BRN: 109591
BCS Class: 3
Stability: Stable. Incompatible with strong oxidizing agents. May be light sensitive.
InChIKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
LogP: 0.360

Niacin (Vitamin B3) wasn’t until about 1943, though, that a couple of doctors reported that niacin worked wonders in relieving the pain and stiffness associated with arthritis.
Niacin (Vitamin B3) excess cholesterol is then excreted throughthe biliary tract.
Niacin (Vitamin B3), also known as B3, Niacin (Vitamin B3) or nicotinamide, is an important enzymatic component required for the body to function normally.

This vitamin allows us to obtain energy from macronutrients (carbohydrates and fats).
Niacin (Vitamin B3) has a unique characteristic.
Niacin (Vitamin B3), a very important micronutrient for energy synthesis, also contributes to the healthy functioning of the nervous and digestive systems.

In addition to these, Niacin (Vitamin B3) is known that it is good for skin health and vitality, hair and eyes.
Niacin (Vitamin B3), an enzymatic component, has an important role in the metabolism of fats and sugars.
In this way, cells have the ability to provide the energy they need to continue their normal functions.

Since Niacin (Vitamin B3) helps regulate fat and cholesterol levels, it can be used for the prevention or treatment of cardiovascular ailments.
Niacin (Vitamin B3), also called Niacin (Vitamin B3) and vitamin B3, water-soluble vitamin of the B complex.
Niacin (Vitamin B3) is also called the pellagra-preventive vitamin because an adequate amount in the diet prevents pellagra, a chronic disease characterized by skin lesions, gastrointestinal disturbance, and nervous symptoms.

Niacin (Vitamin B3) is interchangeable in metabolism with its amide, niacinamide (nicotinamide).
Like the vitamins thiamin (vitamin B1) and riboflavin (vitamin B2), niacin functions as part of a coenzyme involved in the metabolism of carbohydrates and acts to catalyze the oxidation of sugar derivatives and other substances.
Niacin (Vitamin B3), which was identified as a pellagra preventive in 1937, is widely distributed among plants and animals.

Niacin (Vitamin B3) approximately 15 mg per day (1 mg = 0.001 gram) of Niacin (Vitamin B3) is required by humans.
In the intestinal tract, the Niacin (Vitamin B3) tryptophan can be converted to niacin by bacterial action and thus can serve as a source for part of the required Niacin (Vitamin B3).
This explains scientists’ early observation that the protein in such foods as eggs and milk, both poor sources of niacin, can nevertheless prevent or cure pellagra.

Niacin (Vitamin B3) is indicated to prevent vitamin deficiencies in pediatric and adult patients receiving parenteral nutrition as part of multivitamin intravenous injections.
Niacin (Vitamin B3) oral tablets are indicated as a monotherapy or in combination with simvastatin or lovastatin to treat primary hyperlipidemia and mixed dyslipidemia.
Niacin (Vitamin B3) can also be used to reduce the risk of nonfatal myocardial infarctions in patients with a history of myocardial infarction and hyperlipidemia.

Niacin (Vitamin B3) use of supplements containing niacin may be beneficial in terms of weight loss, as the substance will stimulate energy synthesis and help reduce the feeling of fatigue caused by weight loss.
Niacin (Vitamin B3) also positively affects the vitality and health of the skin, eyes and hair and can be used for the treatment of skin conditions such as dermatitis, skin irritation and acne.
Adequate consumption of niacin contributes to the strengthening of the digestive and immune systems, while helping to fight oxidative stress.

Niacin (Vitamin B3) also has positive effects on the health of the nervous system (it triggers units related to cognitive functions and memory).
Niacin (Vitamin B3) deficiency can cause serious symptoms such as muscle weakness, digestive upsets (irritation of the mucus layer in the mouth, stomach, and intestines), loss of appetite, and skin rashes.
In more severe cases, Niacin (Vitamin B3) can cause lesions in the central nervous system, leading to confusion and disorientation.

Studies have shown that Niacin (Vitamin B3) can significantly lower cholesterol levels, but because the product is inexpensive, the pharmaceutical industry has not commercialized this supplement as a combined treatment for hypercholesteremia.
Niacin (Vitamin B3) is amphoteric and forms salts with acids as well as bases.
Niacin (Vitamin B3) is also indicated with bile acid binding resins to treat atherosclerosis in patients with coronary artery disease and hyperlipidemia or to treat primary hyperlipidemia.

Niacin (Vitamin B3) decreases formation and secretion of VLDL by the liver.
This action appears secondary to its ability to inhibit fatty acid mobilization from adipose tissue.
Circulating free fatty acids provide the main source of fatty acids for hepatic triglyceride synthesis, and lowering triglyceride synthesis lowers Niacin (Vitamin B3) formation and secretion by the liver.

Niacin (Vitamin B3) shifts LDL particles to larger (more buoyant) sizes.
The larger LDL particles are thought to be less atherogenic.
Niacin (Vitamin B3) can also significantly increase plasma HDL levels; the mechanism is unknown.

Niacin (Vitamin B3) is also known as vitamin B3, one of the B-complex vitamins.
Vitamins help to support the body's ability to make and break down natural compounds (metabolism) needed for good health.
Niacin (Vitamin B3) (nicotinamide) is a different form of vitamin B3 and does not work the same as niacin.

Niacin (Vitamin B3) is both a vitamin, i.e., an essential nutrient, marketed as a dietary supplement, and in the US, a prescription medicine.
As a Niacin (Vitamin B3), it is precursor of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).
Severe deficiency of Niacin (Vitamin B3) in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death.

Common psychiatric symptoms include irritability, poor concentration, anxiety, fatigue, loss of memory, restlessness, apathy, and depression.
Finally Niacin (Vitamin B3) is indicated to treat severe hypertriglyceridemia.
Niacin (Vitamin B3) is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.

Niacin (Vitamin B3) acts to decrease levels of very low density lipoproteins and low density lipoproteins, while increasing levels of high density lipoproteins.
Niacin (Vitamin B3) can be converted to nicotinamide in the animal body and, in this form, is found as a component of two oxidation-reduction coenzymes, NAD and NADP.
Niacin (Vitamin B3) is taken by mouth for high cholesterol and other fats.

Niacin (Vitamin B3) is also used for low levels of a specific type of cholesterol, HDL.
Niacin (Vitamin B3) is also used along with other treatments for circulation problems, migraine headache, Meniere's syndrome and other causes of dizziness, and to reduce the diarrhea associated with cholera.
Niacin (Vitamin B3) is also taken by mouth to for preventing positive urine drug screens in people who take illegal drugs.

Niacin (Vitamin B3) is taken by mouth for preventing vitamin B3 deficiency and related conditions such as pellagra.
Niacin (Vitamin B3) is also taken by mouth for schizophrenia, hallucinations due to drugs, Alzheimer's disease and age-related loss of thinking skills, chronic brain syndrome, muscle spasms, depression, motion sickness, alcohol dependence, blood vessel swelling linked with skin lesions, and fluid collection (edema).
Some people take Niacin (Vitamin B3) by mouth for acne, leprosy, attention deficit-hyperactivity disorder (ADHD), preventing premenstrual headache, improving digestion, protecting against toxins and pollutants, reducing the effects of aging, arthritis, lowering blood pressure, improving circulation, promoting relaxation, improving orgasms, and preventing cataracts.

Niacin (Vitamin B3) is a member of the B family of vitamins (B complex).
Niacin (Vitamin B3)a water-soluble vitamin.
Like the other B vitamins, Niacin (Vitamin B3) helps make energy in your body.

Niacin (Vitamin B3) helps your body use carbohydrates, fatty acids, and proteins.
Niacin (Vitamin B3) is found in many plant and animal foods, such as yeast, meats (especially liver), grains, legumes, corn treated with alkali (such as corn used in tortillas), and seeds.
Niacin (Vitamin B3) can be made by the liver from the amino acid tryptophan.

Niacin (Vitamin B3) can be manufactured by plants and animals from the amino acid tryptophan.
Niacin (Vitamin B3) is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.
Niacin (Vitamin B3) as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.

Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide derivative Niacin (Vitamin B3) (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Niacin (Vitamin B3) is also used to improve exercise performance.

Niacin (Vitamin B3) is a water-soluble vitamin that cannot be stored in body fat.
Niacin (Vitamin B3) has two active components, Niacin (Vitamin B3) (niacin) and nicotinamide (niacinamide).

Niacin (Vitamin B3) plays a role in over 200 enzymatic reactions.
The nicotinamide portion of the coenzyme transfers hydrogens by alternating between an oxidized quaternary nitrogen and a reduced tertiary nitrogen.

History:
Huber first synthesized Niacin (Vitamin B3) in 1867. In 1914, Funk isolated Niacin (Vitamin B3) from rice polishings.
Goldberger, in 1915, demonstrated that pellagra is a nutritional deficiency.
In 1917, Chittenden and Underhill demonstrated that canine blacktongue is similar to pellagra.

In 1935, Warburg and Christian showed that niacinamide is essential in hydrogen transport as diphosphopyridine nucleotide (DPN).
In the following year, Euler et al. isolated DPN and determined its structure.
In 1937, Elvhehjem et al. cured blacktongue by administration of Niacin (Vitamin B3) derived from liver.

In the same year, Fouts et al. cured pellagra with niacinamide.
In 1947, Handley and Bond established conversion of tryptophan to niacin by animal tissues
Carpenter found in 1951, that niacin in corn is biologically unavailable, and can be released only in very alkaline lime water of pH 11.

This explains why a Latin-American culture that used alkali-treated cornmeal to make tortilla was not at risk for niacin deficiency.
In 1955, Altschul and colleagues described large amounts of niacin as having a lipid-lowering property.

As such, Niacin (Vitamin B3) is the oldest known lipid-lowering drug.
Lovastatin, the first 'statin' drug, was first marketed in 1987.

Mechanisms:
Niacin (Vitamin B3) reduces synthesis of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), lipoprotein(a) and triglycerides, and increases high-density lipoprotein cholesterol (HDL-C).
The lipid-therapeutic effects of niacin are partly mediated through the activation of G protein-coupled receptors, including hydroxycarboxylic acid receptor 2 (HCA2)and hydroxycarboxylic acid receptor 3 (HCA3), which are highly expressed in body fat.

HCA2 and HCA3 inhibit cyclic adenosine monophosphate (cAMP) production and thus suppress the release of free fatty acids (FFAs) from body fat, reducing their availability to the liver to synthesize the blood-circulating lipids in question.
A decrease in free fatty acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL-C turnover and reducing its production.
Niacin (Vitamin B3) also directly inhibits the action of diacylglycerol O-acyltransferase 2 (DGAT2) a key enzyme for triglyceride synthesis.

Preparation:
Niacin (Vitamin B3) exists naturally in grain germs, meats and peanuts.
Niacin (Vitamin B3) can also be synthesized artificially through the liquid phase method (potassium permanganate oxidation and nitric acid oxidation) and gas phase method (ozone oxidation, ammonia oxidation and air oxidation).
In the gas phase ammonia oxidation process, add 3-methyl pyridine, air and ammonia into the fluidized bed reactor and catalyze the reaction at 290～360℃,V2O5 to produce nicotinonitrile; then hydrolyze in sodium hydroxide aqueous solution at 160℃ to produce sodium nicotinate; finally, add hydrochloric acid to acidify, creating Niacin (Vitamin B3).

In the potassium permanganate oxidation method, add potassium permanganate gradually at 80℃ to a mixture of 3-methyl pyridine and water, and then continue to mix for 30min at 85～90℃.
Distill to collect and reuse the unreacted 3-methyl pyridine and filter away the produced manganese dioxide.
Adjust the PH of the resulting Niacin (Vitamin B3) solution to 3.8～4.0 using hydrochloric acid, cool to 30℃ crystals, and filter to obtain crude Niacin (Vitamin B3).

Dissolve the crude Niacin (Vitamin B3) in hot water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
6- hydroxyquinoline method Add sulfuric acid and quinoline into a reaction kettle and mix while maintaining heat at 150～160℃ for 5h.
Then with the temperature maintained at 180～220℃, slowly drop in nitric acid and the sulfuric acid mixture over the course of 36～40h.

While maintaining the temperature, mix for 2～3h to obtain a Niacin (Vitamin B3) solution and add water to dilute the solution.
Use 30％～33％ NaOH solution to neutralize the PH to 8～9.
Cool and filter away the sodium sulfate and sodium nitrate crystals, add copper sulfate solution to the filtered liquid, and mix and heat to yield copper nicotinate precipitation.

Cool, filter and add the copper nicotinate to an adequate amount of water, drop in NaOH solution until PH>9 and the liquid is no longer blue, and filter away the produced cupric oxide.
Add a small amount of sodium sulfide solution to remove traces of copper and iron until the solution no longer produces black precipitate, and then filter.
Use hydrochloric acid to adjust the PH of the filtered liquid to 3.5～3.9, filter to yield crystals as crude Niacin (Vitamin B3).

Dissolve the crude product in 12 times the amount of distilled water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
Yield is 35％～39％.
2-methyl-5-ethyl pyridine method With 2-methyl-5-ethyl pyridine as the raw ingredient, oxidize with nitic acid under high pressure and high temperatures, then decarboxylate to yield Niacin (Vitamin B3).

Uses:
Niacin (Vitamin B3) is used as a medication to help lower elevated levels of LDL (low-density lipoprotein) cholesterol and triglycerides in the blood while increasing HDL (high-density lipoprotein) cholesterol.
Niacin (Vitamin B3) can help address issues like acne, dry skin, and skin aging.
Niacin (Vitamin B3) has been used in the prevention of migraines, although its effectiveness can vary from person to person.

Some studies have suggested that niacin supplementation may help improve certain symptoms of schizophrenia when used in combination with other medications.
Niacin (Vitamin B3) is involved in various metabolic processes in the brain and may play a role in maintaining cognitive function.
Some research has explored its potential in Alzheimer's disease and age-related cognitive decline, though results are inconclusive.

High-dose Niacin (Vitamin B3) has been used in certain detoxification programs for individuals trying to eliminate traces of illicit drugs, particularly marijuana, from their system.
This approach is controversial and should only be done under medical supervision.
Niacin (Vitamin B3) is a crucial component in the production of energy within cells. It helps convert food into energy and is involved in various metabolic pathways.

Niacin (Vitamin B3) has been shown to lower levels of Lp(a) cholesterol, which is associated with an increased risk of cardiovascular disease.
Niacin (Vitamin B3) can be used in specific cases to target elevated Lp(a) levels.
Niacin (Vitamin B3) is often prescribed for individuals with high cholesterol or those at risk of heart disease.

Due to its cholesterol-lowering properties, Niacin (Vitamin B3) can be prescribed to reduce the risk of heart attacks and strokes in certain patients with cardiovascular disease.
Niacin (Vitamin B3) is sometimes used to treat hyperlipidemia, a condition characterized by high levels of lipids (fats) in the blood.
Niacin (Vitamin B3) can also be used to manage dyslipidemia, a condition involving abnormal lipid levels in the blood, including high LDL cholesterol and triglycerides.

In some cases, Niacin (Vitamin B3) may be used to improve blood circulation in people with certain vascular conditions, like intermittent claudication, a symptom of peripheral arterial disease.
Niacin (Vitamin B3) is sometimes used topically or in skincare products to improve the health and appearance of the skin.
Niacin (Vitamin B3) is an important factor in delivering hydrogen and fighting pellagra in organisms; it helps maintain skin and nerve health and stimulate digestion.

Niacin (Vitamin B3) or niacinamide are used to treat and prevent pellagra.
This is a disease caused by niacin deficiency.
Niacin (Vitamin B3) is also used to treat high cholesterol.

In some cases, niacin taken with colestipol can work as well as colestipol and a statin medicine.
Niacin (Vitamin B3) USP granular is used for food fortification, as dietary supplement and as an intermediate of pharmaceuticals.
Niacin (Vitamin B3) feed grade is used as vitamin for poultry, swines, ruminants, fish, dogs and cats, etc.

Niacin (Vitamin B3) is also used as intermediate for Niacin (Vitamin B3) derivatives and technical applications.
Niacin (Vitamin B3) is used to prevent and treat niacin deficiency (pellagra).
Niacin (Vitamin B3) deficiency may result from certain medical conditions (such as alcohol abuse, malabsorption syndrome, Hartnup disease), poor diet, or long-term use of certain medications (such as isoniazid).

Niacin (Vitamin B3), a form of niacin, is used in skincare products to address various skin conditions, such as acne, rosacea, and hyperpigmentation.
Niacin (Vitamin B3) can help improve the appearance and texture of the skin.
Niacin (Vitamin B3) has anti-inflammatory properties and is used in skincare products to soothe and calm irritated skin.

Niacin (Vitamin B3) may also help reduce redness associated with certain skin conditions.
In addition to treating pellagra caused by niacin deficiency, Niacin (Vitamin B3) can sometimes be used to alleviate pellagra-like conditions that may result from other medical conditions or medications.
Niacin (Vitamin B3) deficiency can cause diarrhea, confusion (dementia), tongue redness/swelling, and peeling red skin.

Niacin (Vitamin B3) is also known as niacin and vitamin B3.
Niacin (Vitamin B3) is a water-soluble conditioning agent that improves rough, dry, or flaky skin, helping smooth the skin and improve its suppleness.

Niacin (Vitamin B3) enhances the appearance and feel of hair, by increasing body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
When used in the formulation of skin care products, niacinamide and niacin enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness.
Niacin (Vitamin B3) is a precursor of the coenzymes NAD and NADP.

Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains.
Niacin (Vitamin B3) is a water-soluble b-complex vitamin that is necessary for the growth and health of tissues.
Dietary deficiency is associated with pellagra.

Niacin (Vitamin B3) was functions as a nutrient and dietary supplement that prevents pellagra.
The term "Niacin (Vitamin B3)" has also been applied.

Safety Profile:
Niacin (Vitamin B3)v poison by intraperitoneal route.
Niacin (Vitamin B3), questionable carcinogen with experimental carcinogenic data.
When heated to decomposition it emits toxic fumes of NOx.

Moderately toxic by ingestion, intravenous, and subcutaneous routes.
Human systemic effects: change in clotting factors, changes in platelet count.

Synonyms:
Niacin (Vitamin B3)
niacin
59-67-6
Pyridine-3-carboxylic acid
3-pyridinecarboxylic acid
3-Carboxypyridine
wampocap
vitamin B3
Niaspan
Acidum nicotinicum
nicolar
Apelagrin
Pellagrin
Akotin
Daskil
Efacin
Pelonin
Linic
nicamin
nicobid
nicocap
Enduracin
Nicodelmine
Niconacid
Nicotinipca
Pellagramin
Direktan
Nicacid
Nicangin
Peviton
Bionic
Diacin
Nicyl
Nyclin
Niac
Vitaplex N
Davitamon PP
Nico-Span
Tega-Span
Nicocidin
Nicocrisina
Niconazid
Nicotamin
Nicotene
Nicovasan
Nicovasen
Nipellen
SK-Niacin
Naotin
Niacor
Nicodon
Niconat
Nicosan 3
Nicosyl
Nicotil
Tinic
3-Carboxylpyridine
Nicotine acid
Nicodan
Nicoside
Slo-niacin
NICO
3-Picolinic acid
Nicotinsaure
Nico-400
Acide nicotinique
Pyridine-beta-carboxylic acid
Nicagin
anti-Pellagra vitamin
Caswell No. 598
PP Factor
Kyselina nikotinova
P.P. factor
Pellagra preventive factor
S115
Nicotinsaure [German]
Acido nicotinico
3-Pyridylcarboxylic acid
m-Pyridinecarboxylic acid
Niacin [USAN]
Kyselina nikotinova [Czech]
C6H5NO2
MFCD00006391
niacine
CCRIS 1902
Pyridine-carboxylique-3
EPA Pesticide Chemical Code 056701
Acide nicotinique [INN-French]
Acido nicotinico [INN-Spanish]
Acidum nicotinicum [INN-Latin]
HSDB 3134
Pyridine-carboxylique-3 [French]
AI3-18994
Pyridinecarboxylic acid, 3-
Niacin [USP]
SR 4390
BRN 0109591
Niacin extended release
Niacin (Vitamin B3) [INN]
Vitamin B3 (Niacin)
Niacin (Niacin (Vitamin B3))
EINECS 200-441-0
NIASPAN TITRATION STARTER PACK
NAH
CHEMBL573
beta-pyridinecarboxylic acid
NSC 169454
NSC-169454
niacin magnesium
niacin potassium
MLS000069603
Pyridine-.beta.-carboxylic acid
DTXSID1020932
UNII-2679MF687A
CHEBI:15940
Niacin (USP)
Niacinamide (TN)
2679MF687A
P.P. factor-pellagra preventive factor
Nicotinamide (TN)
CAS-59-67-6
NCGC00016268-02
Niacin (TN)
SMR000059024
[3H]Niacin (Vitamin B3)
[5, 6-3H]-niacin
EC 200-441-0
[3H]-Niacin (Vitamin B3)
5-22-02-00057 (Beilstein Handbook Reference)
DTXCID10932
Nicotinicacid
Induracin
SR-01000722017
pellagra
Nikotinsaeure
Ncotnc acd
preventative factor
Niacin-Vitamin B3
Niaspan (TN)
3PyrCOOH
Niacor (TN)
Niacin (Vitamin B3),(S)
Niacinamide Astra Brand
Niacinamide Merck Brand
Spectrum_001063
Niacin (Vitamin B3), Ph Eur
NIACIN [VANDF]
NIACIN [HSDB]
NIACIN [INCI]
5-pyridinecarboxylic acid
NIACIN [FCC]
NIACIN [USP-RS]
Opera_ID_1346
Prestwick0_000881
Prestwick1_000881
Prestwick2_000881
Prestwick3_000881
Pyridine-3-carbonic acid
Spectrum2_000006
Spectrum3_000515
Spectrum4_000965
Spectrum5_001287
VITAMIN B-3
3-Pyridyl carboxylic acid
Niacin (Vitamin B3)-d3(major)
Nicotinamide-carbonyl-14C
Niacin (Vitamin B3); (Niacin)
WLN: T6NJ CVQ
3-pyridine carboxylic acid
Astra Brand of Niacinamide
bmse000104
D06NVJ
Merck Brand of Niacinamide
Niacinamide Jenapharm Brand
Niacin (Vitamin B3), >=98%
Niacin (Vitamin B3), USP grade
SCHEMBL1433
Nicotinamide (JP15/INN)
Niacin (Vitamin B3) [INN:BAN]
Niacin (Vitamin B3); (Niacin)
Niacin (Vitamin B3) [MI]
Niacinamide Pharmagenix Brand
Oprea1_514398
VITAMIN B3 [VANDF]
BSPBio_000662
BSPBio_002069
KBioGR_001309
KBioSS_001543
NIACIN [ORANGE BOOK]
Niacin (Vitamin B3) [JAN]
Niacin (Vitamin B3) (Vitamin B3)
BIDD:GT0644
DivK1c_000695
Niacin (Vitamin B3) (JP17/INN)
SIMCOR COMPONENT NIACIN
SPECTRUM1500430
.beta.-Pyridinecarboxylic acid
Jenapharm Brand of Niacinamide
SPBio_000011
SPBio_002881
ADVICOR COMPONENT NIACIN
NIACIN [USP MONOGRAPH]
Niacin (Vitamin B3) [VANDF]
BPBio1_000730
GTPL1588
GTPL1594
Niacin (Vitamin B3) [MART.]
Niacin (Vitamin B3) [WHO-DD]
Niacin (Vitamin B3) [WHO-IP]
Pharmagenix Brand of Niacinamide
BDBM23515
HMS502C17
KBio1_000695
KBio2_001543
KBio2_004111
KBio2_006679
KBio3_001569
ABT-919
NIACIN COMPONENT OF SIMCOR
Niacin (Vitamin B3) [EMA EPAR]
NINDS_000695
HMS1570B04
HMS1920P17
HMS2091H22
HMS2097B04
HMS2236A05
HMS3259K21
HMS3371E07
HMS3655K08
HMS3714B04
NIACIN COMPONENT OF ADVICOR
Pharmakon1600-01500430
Niacin (Vitamin B3), analytical standard
BCP16301
HY-B0143
STR00112
Tox21_110337
Tox21_201420
Tox21_302904
AC8691
BBL037343
CCG-38340
Niacin (Vitamin B3) [EP IMPURITY]
Niacin (Vitamin B3), for synthesis, 99%
NSC169454
NSC757241
s1744
STK301803
Niacin (Vitamin B3) [EP MONOGRAPH]
AKOS000118980
Niacin (Vitamin B3), >=99.5% (HPLC)
Tox21_110337_1
AM81316
CS-1946
DB00627
LS-2334
NC00524
Niacin (Vitamin B3) 1.0 mg/ml in Methanol
NSC-757241
PS-4255
SDCCGMLS-0066610.P001
IDI1_000695
NCGC00016268-01
NCGC00016268-03
NCGC00016268-04
NCGC00016268-05
NCGC00016268-08
NCGC00016268-09
NCGC00094734-01
NCGC00094734-02
NCGC00256537-01
NCGC00258971-01
AC-22484
ACIDUM NICOTINICUM [WHO-IP LATIN]
BP-21419
NCI60_001041
Niacin (Vitamin B3), NIST(R) SRM(R) 148
Niacin (Vitamin B3), plant cell culture tested
SY011111
SBI-0051456.P003
Niacin (Vitamin B3) [Matrix for MALDI-TOF/MS]
AB00052050
FT-0600004
FT-0672715
FT-0672716
FT-0672717
FT-0672718
FT-0773496
N0082
N1103
Niacin (Vitamin B3) 10 microg/mL in Acetonitrile
Niacin (Vitamin B3), purum, >=99.0% (HPLC)
SW197229-3
EN300-16693
C00253
D00049
Niacinamide, Niacin (Vitamin B3) amide, Nicotinamide
Niacin (Vitamin B3), SAJ special grade, >=99.5%
AB00052050-13
AB00052050_14
AB00052050_15
Niacin (Vitamin B3), meets USP testing specifications
AC-907/25014105
L001199
METHYL NICOTINATE IMPURITY A [EP IMPURITY]
Niacin (Vitamin B3), Vetec(TM) reagent grade, >=98%
Q134658
J-523605
SR-01000722017-2
SR-01000722017-3
SR-01000722017-4
Z56755709
3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E
F2191-0082
Niacin, United States Pharmacopeia (USP) Reference Standard
Niacin (Vitamin B3), certified reference material, TraceCERT(R)
Niacin (Vitamin B3), European Pharmacopoeia (EP) Reference Standard
Niacin (Vitamin B3), matrix substance for MALDI-MS, >=99.5% (HPLC)
InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9
Niacin (Vitamin B3), for inorganic trace analysis, >=99.999% (metals basis)
Niacin (Niacin (Vitamin B3)), Pharmaceutical Secondary Standard; Certified Reference Material
101113-41-1
Niacin (Vitamin B3), BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98%

Niacinamide is a form of vitamin B3(niacin), a water-soluble vitamin; used in cosmetics and personal care products as a conditioning agent.
Niacinamide, also called nicotinamide, is a form of vitamin B3.
Niacinamide's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.


CAS Number: 98-92-0
EC Number: 202-713-4
MDL number: MFCD00006395
Empirical Formula (Hill Notation): C6H6N2O


Niacinamide, also called nicotinamide, is a form of vitamin B3.
Niacinamide's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.
Niacinamide is required for the function of fats and sugars in the body and to maintain healthy cells.


Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Unlike niacin, niacinamide doesn't help treat high cholesterol.
Do not confuse niacinamide with niacin, NADH, nicotinamide riboside, inositol nicotinate, or L-tryptophan.


These are not the same.
Niacinamide, or nicotinamide, is a type of vitamin B-3.
Taking Niacinamide can help prevent B-3 deficiency and may treat acne and eczema.


More research is needed, however.
Preventing B-3 deficiency is important because it can lead to disorders of the skin, kidneys, and brain.
But, there’s much more to niacinamide, especially when it comes to general skin health.


Despite the similarities in names, niacinamide isn’t the same thing as niacin.
They’re two different types of vitamin B-3.
However, your body can make niacinamide from niacin supplements you’ve taken.


This happens when there’s an excessive amount of niacin in the body.
Tryptophan in the body can also be converted into niacinamide.
Niacinamide is a form of vitamin B3, which your body needs to help maintain healthy-looking skin.


There are three forms of vitamin B3—niacinamide (nicotinamide), niacin (nicotinic acid), and nicotinamide riboside—but niacinamide is the ingredient that’s most popularly used in skincare products.
Vitamin B3 can be found in niacin-rich foods, such as fish, poultry, grains, nuts, and legumes.


Niacinamide is not produced naturally by your body, so in order to gain the benefits of niacinamide for skin, you’ll need to seek out external sources—such as skincare products formulated with niacinamide.
Niacinamide or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.


Niacinamide is in the vitamin B family of medications, specifically the vitamin B3 complex.
Niacinamide is an amide of nicotinic acid.
Foods that contain niacinamide include yeast, meat, milk, and green vegetables.


Niacinamide was discovered between 1935 and 1937.
Niacinamide is on the World Health Organization's List of Essential Medicines.
Niacinamide is available as a generic medication and over the counter.


Commercially, niacinamide is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries grains have niacinamide added to them.
Although the word Niacinamide may sound a little scary, it’s basically Vitamin B3, an essential nutrient for your skin.


This is why Niacinamide can help your skin look healthier.
Niacinamide, also called nicotinamide, is a form of vitamin B3.
Niacinamide's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.


Niacinamide is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Unlike niacin, niacinamide doesn't help treat high cholesterol.


Niacinamide is a type of vitamin B3, one of eight B vitamins that support many aspects of your health.
Your body makes niacinamide when you have too much niacin in your body.
Your body can also change an amino acid called tryptophan into niacinamide.


Niacinamide can prevent pathological changes of skin and diseases of alimentary canal, such as dermatitis, black tongue, vomiting and diarrhea etc.
By participating in material and energy metabolism, Niacinamide CAS 98-92-0 can promote the body growth.
By combining with other medicines, Niacinamide can cure catarrh and ulcer.


By improving the ability of blood supply with strong expansion function of blood vessel, Niacinamide is highly effective in curing such diseases as dermatosis, hypercholesterolemia disease and coronary heart disease.
Also known as Vitamin B3, this lab-born ingredient is a major multi-tasker.


For context: Niacinamide works to support skin’s barrier while it also helps to brighten dull-looking skin.
Niacinamide (nicotinamide) is a form of vitamin B3.
"Vitamin B3" can mean niacinamide (nicotinamide) or nicotinic acid (niacin).


Some companies may label Niacinamide and nicotinic acid as "niacin." However, niacin and niacinamide are different forms of vitamin B3.
They have different chemical structures that work differently in your body.
For example, niacinamide doesn't reduce cholesterol levels like niacin.


Niacinamide is a water-soluble vitamin, meaning it's not stored in the body.
You need to consume it through food or supplements.
Your body needs niacinamide to create energy.


Your cells need it to function correctly.
Niacinamide might not get quite as much buzz as ingredients like retinol and vitamin C, but the skincare superstar is an unsung hero that deserves equal praise.


Niacinamide's the very definition of a multitasker—it's even found in many of the best drugstore shampoos—offering a litany of different benefits that make it a great pick for a wide variety of skin types and complexion concerns.
Niacinamide appears as an active ingredient in several affordable skincare brands.


Niacinamide is often dubbed as the all-rounder hero in many skincare routines.
Niacinamide holds countless benefits for all different skin types, so it’s not hard to see why everyone is obsessed.
But if you’re wondering what is niacinamide and what does niacinamide do, we’ve got all the answers for you.


Keep reading to find out all the deets.
Niacinamide is also known as vitamin B3 and is a water-soluble vitamin that works with your skin’s natural oils and vitamins to achieve results.
It’s an essential nutrient for your skin, which is why many people experience noticeable results once they add niacinamide to their routine.


Niacinamide, also known as nicotinamide, is a form of Vitamin B3 (niacin).
Niacinamide is water-soluble, meaning that it is not stored in the body, so it's crucial to replenish our niacinamide reserves orally via the food we eat (poultry, green vegetables and eggs are good sources), and topically with targeted skincare products.


While you can get sources of vitamin B3 through your diet, topical application can accelerate the benefits.
Niacinamide sounds like a beauty brand’s chemistry-lab invention (just us?), but the increasingly popular skin-care ingredient is actually just a form of vitamin B3.



USES and APPLICATIONS of NIACINAMIDE:
People use niacinamide to prevent vitamin B3 deficiency and related conditions such as pellagra.
Niacinamide is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.


Also known as vitamin B3 and nicotinamide, niacinamide is a water-soluble vitamin that works with the natural substances in your skin to help visibly minimize enlarged pores, tighten lax or stretched out pores, improve uneven skin tone, soften fine lines and wrinkles, diminish dullness, and strengthen a weakened surface.


Niacinamide also reduces the impact of environmental damage because of its ability to improve skin’s barrier (its first line of defense), plus it also plays a role in helping skin to repair signs of past damage.
Left unchecked, this type of daily assault makes skin appear older, dull and less radiant.


Niacinamide, also known as vitamin B3 or nicotinamide, is a water-soluble B vitamin that plays an important —in cleansers eye creams, serums, and sunscreens.
When used as part of your daily skincare regimen, niacinamide may help calm your skin, reduce transepidermal water loss (TEWL), and increase moisture in your skin’s uppermost layer.


This makes niacinamide a helpful skincare ingredient for those looking to promote hydrated, even-toned skin.
First studied for its skincare benefits in the 1970s, niacinamide has since become a popular cosmetic ingredient in formulations for multiple skin types and skin concerns.


As a supplement, Niacinamide is used by mouth to prevent and treat pellagra (niacin deficiency).
While nicotinic acid (niacin) may be used for this purpose, niacinamide has the benefit of not causing skin flushing.
As a cream, Niacinamide is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.


Niacinamide is a water-soluble vitamin.
Niacinamide is the supplement name while nicotinamide is the scientific name.
Skin cancer: Niacinamide at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.


Niacinamide can be found in vitamin-rich foods, such as kale, mushrooms and almonds, which help take great care of your body from the inside, as well as in skin care products to pamper it from the outside.
People use niacinamide to prevent vitamin B3 deficiency and related conditions such as pellagra.


Niacinamide is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.


Niacinamide is a form of vitamin B3(niacin), a water-soluble vitamin; used in cosmetics and personal care products as a conditioning agent.
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider.
No supplement is intended to treat, cure, or prevent disease.


-Medical uses:
*Niacin deficiency:
Niacinamide is the preferred treatment for pellagra, caused by niacin deficiency.


-Acne:
Niacinamide cream is used as a treatment for acne.
Niacinamide has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Niacinamide increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.
The application of 2% topical niacinamide for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Niacinamide has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.



WHERE SHOULD I USE NIACINAMIDE?
If you’ve made it to this point, chances are you’re sold on adding niacinamide into your routine.
But you might have some questions.
How should you use niacinamide?

Should niacinamide be used in the morning or at night?
Should niacinamide be used every day?
Niacinamide can be used morning and night on a daily basis.

It’s compatible with pretty much every other skincare ingredient, so don’t worry about adding it to your skincare stack.
While it has many benefits for your face, it can also be used on the neck, chest, and back, particularly if you’re investing due to the acne-fighting benefits.



WHAT BENEFITS DOES NIACINAMIDE OFFER?
Overall, niacinamide can help build proteins in the skin and lock in moisture to prevent environmental damage.



INDIVIDUAL BENEFITS OF NIACINAMIDE INCLUDE:
*Immunity.
Niacinamide helps build keratin, a type of protein that keeps your skin firm and healthy.

*Lipid barrier:
Niacinamide can help your skin grow a ceramide (lipid) barrier, which can, in turn, helps retain moisture.
This is beneficial for all skin types, especially if you have eczema or mature skin.

*Minimizes redness and blotchiness:
Niacinamide reduces inflammation, which may help ease redness from eczema, acne, and other inflammatory skin conditions.

*Minimizes pore appearance:
Keeping skin smooth and moisturized may have a secondary benefit — a natural reduction in pore size over time.

*Regulates oil:
The benefits of moisture retention aren’t just for those with dry skin types.
Niacinimide can also help regulate the amount of oil the sebaceous glands produce and prevent your glands from going into overdrive.
Niacinamide protects against sun damage.
Niacinamide can concurrently rebuild healthy skin cells while also protecting them from damage caused by ultraviolet rays.

*Treats hyperpigmentation:
Some research has found that 5 percent niacinamide concentrations can be helpful in lightening dark spots.
Benefits were seen after four weeks, but not beyond two months.
This benefit may be due to increased collagen production.

*Minimizes fine lines and wrinkles:
Research has also found that the same concentration was helpful in reducing some signs of sun damage that come with aging.
This includes fine lines and wrinkles.
Protects against oxidative stress.
Niacinamide helps build cells in the skin while also protecting them from environmental stresses, such as sunlight, pollution, and toxins.

*Treats acne:
Niacinamide may be helpful for severe acne, especially inflammatory forms like papules and pustules.
Over time, you may see fewer lesions and improved skin texture.



DOES THE TYPE OF SKIN CARE PRODUCT MATTER OR WHEN NIACINAMIDE IS USED IN YOUR ROUTINE?
Many niacinamide products come in the form of serums.
Think of serums as extra treatments that address individual skin concerns outside of regular cleansing, toning, and moisturizing.
Your niacinamide serum should be applied after toning but before moisturizing.
Some cleansers and creams also contain niacinamide.
Niacinamide is also found in some face masks, which are rinsed off after each use.



WHAT SHOULD I TOOK FOR WHEN SELECTING A PRODUCT?
Niacinamide concentration can vary across products, though most formulations are 5 percent or less.
Some reports suggest 5 percent formulas are effective in treating hyperpigmentation and damage related to sun exposure.
If you have sensitive skin, you may want to start with a lower concentration. Formulas with 2 percent niacinamide may help ease symptoms of eczema and similar conditions.
Niacinamide may be listed as “niacin” and “nicotinamide” on product labels.



CAN NIACINAMIDE BE COMBINED WITH OTHER SKIN CARE INGREDIENTS FOR MAXIMUM EFFECT?
Niacinamide may be used alongside other active ingredients for optimal results.
For example, some reports suggest that supplemental niacinamide may work well alongside copper, folic acid, and zinc to treat acne.
You may be able to get more out of your niacinamide serum by using it alongside hyaluronic acid.

Hyaluronic acid is said to increase product absorption.
Niacinamide has a plethora of benefits as a skin care ingredient including its ability to:
Minimize the appearance of enlarged pores and improve “orange peel” textured skin

Restore skin’s defenses against moisture loss and dehydration
Visibly even out skin tone and discolorations from sun damage
Among a handful of other amazing skin care ingredients such as retinol and vitamin C, niacinamide is a standout because of its versatility for almost any skin care concern and skin type.



WHAT DOES NIACINAMIDE DO FOR YOUR SKIN?
Niacinamide’s abilities are made possible thanks to its status as a multitasking bio-active ingredient.
However, this powerhouse form of vitamin B takes a bit of a journey before our skin and its supporting surface cells can reap its benefits.
After niacinamide’s applied to skin, it’s broken down into the form of this vitamin that our cells can use, the coenzyme nicotinamide adenine dinucleotide.
Niacinamide’s this coenzyme that’s believed to be responsible for niacinamide’s benefits to skin.



NIACINAMIDE SKIN BENEFITS:
This multitalented ingredient is truly one that all can add to their routine, no matter skin type or skin concern.
Some people’s skin may have more concerns niacinamide can address, but without question everyone’s skin will gain something from this B vitamin.

*Minimizes enlarged pores
Niacinamide is most famous for its ability to reduce the appearance of enlarged pores. 
As we touched on above, research hasn’t determined how this B vitamin works its pore-reducing magic, but it seems that niacinamide has a normalizing ability on the pore lining.

This plays a role in helping to keep oil and debris from getting backed up, which leads to clogs and rough, bumpy skin.
As the clog forms and worsens, the pores stretch to compensate, leading to enlargement.

Routine usage of niacinamide helps pores return to their natural size.
Sun damage can cause pores to become stretched, too, leading to what some describe as "orange peel skin".
Higher concentrations of niacinamide can help visibly tighten pores by shoring up skin’s supportive elements, often dramatically improving orange peel texture.

*Added moisture
Other benefits of niacinamide are that it helps renew and restore skin's surface against moisture loss and dehydration. 
When key fatty acids in skin’s barrier known as ceramides gradually deplete, skin is left vulnerable to all sorts of problems, from persistent patches of dry, flaky skin to increasingly becoming extra-sensitive.

If you struggle with dry skin, topical application of niacinamide has been shown to boost the hydrating ability of moisturizers so skin’s surface can better resist the moisture loss that leads to recurrent dryness and flaky texture.
Niacinamide works brilliantly with common moisturizer ingredients like glycerin, non-fragrant plant oils, cholesterol, sodium PCA, and sodium hyaluronate.

*Brightens skin
How does niacinamide help discolorations and uneven skin tone? 
Both concerns stem from excess melanin (skin pigment) showing on skin’s surface.
In concentrations of 5% and greater, niacinamide works via several pathways to keep new discolorations from appearing.

At the same time, it also helps reduce the appearance of existing discolorations, so your skin tone looks more even.
Research has shown niacinamide and tranexamic acid work particularly well together, and as mentioned above, it can be used with other discoloration-reducing ingredients such as all forms of vitamin C, licorice, retinol, and bakuchiol.



CAN YOU USE NIACINAMIDE WITH RETINOL?
Yes!
In fact, dermatologists say that retinol and niacinamide is a recommended combination for achieving quicker results.
Niacinamide's calming benefits can also combat the negative side effects and irritation that often come alongside retinol's wrinkle-fighting magic.



HOW TO USE NIACINAMIDE:
Niacinamide is compatible with other powerful ingredients like peptides, hyaluronic acid, AHAs, BHA, and all types of antioxidants. 
This multi-ingredient approach to skin care is important because as great as niacinamide is, it’s not the only ingredient skin needs to look and feel its best.
Think of it like your diet—as healthy as kale is, if kale was all you ate, you’d soon become malnourished because your body needs more than one healthy food to maintain itself.
The same is true for skin, the body’s largest (and most exposed) organ.



ADDING NIACINAMIDE IN SKIN CARE ROUTINE:
Using niacinamide is as easy as finding great skin care products that contain it and applying it in order of:
*Cleanser
*Toner
*Exfoliant
*Layer the rest of your skin care serums, treatments, and moisturizers (including those with niacinamide) in order of thinnest to thickest texture
*During the day, finish with a broad-spectrum sunscreen rated SPF 30 or greater

How long does niacinamide take to work?
Generally speaking, you should start to see results after 2-4 weeks of twice daily usage (depending on the severity of your skin concerns and how concentrated your niacinamide product is).
Ongoing use is required for continued improvement and maintaining results.

Results will continue to improve over time but do not expect your skin to be completely “poreless”—that isn’t possible for any skin care product (not to mention, your skin needs its pores for many vital functions).
What you can expect is pores that look smaller, skin tone that looks more even, visibly reduced fine lines and wrinkles, and an overall healthier glow.



RECOMMENDED NIACINAMIDE PRODUCTS:
For best results, use niacinamide products that are meant to be left on skin (such as serums or moisturizers) instead of rinse-off products (like cleansers) where contact time is limited.
Niacinamide toner can be especially beneficial when applied after cleansing to rehydrate and replenish skin.

A concentrated 10% Niacinamide Booster can be used on its own (much like a serum) or mixed into your favorite non-SPF moisturizer, based on personal preference.
Those with stubborn concerns around advanced signs of sun damage, orange peel texture, lax pores, and oil-related bumps should consider trying an advanced strength 20% niacinamide serum.

You can use niacinamide-containing products around your eyes, too.
Some might find applying a moisturizer or niacinamide eye cream helps soften the appearance of crow’s feet and dark circles, not to mention enables this delicate area to retain skin-smoothing moisture and resist loss of firmness.
Facial care products with niacinamide can also be applied to the neck and chest.

For skin concerns beyond the face and neck, a niacinamide body serum can be advantageous.
Niacinamide’s benefits on the body include tackling uneven tone, discolorations (including dotted marks around the hair follicles), plus restoring and strengthening skin’s moisture barrier.
Niacinamide Body Serum targets uneven tone and signs of aging on the body, making it a terrific addition to any post-shower body care routine.



WHAT DOES NIACINAMIDE DO FOR SKIN?
Research shows that niacinamide has the potential to help support a healthy skin barrier.
When applied topically, niacinamide can help reduce moisture loss and skin dehydration.
It may also help calm your skin and has been shown to have antioxidant capabilities.
This makes niacinamide a popular ingredient in formulas aimed at improving visible signs of environmental damage—like premature skin aging and skin discoloration.



WHAT IS NIACINAMIDE GOOD FOR IN SKINCARE PRODUCTS?
Niacinamide can help your skin appear healthier and more radiant when used as part of a consistent skincare routine.
Although it’s most commonly-known for its skin-brightening and hydrating properties, niacinamide’s skin benefits also include its ability to help calm your skin, reduce the appearance of redness, and improve uneven skin texture.
The benefits of niacinamide may be especially helpful for blemish-prone skin and mature skin, since this ingredient can help soothe skin and help minimize the appearance of wrinkles and large pores.



CAN NIACINAMIDE BE USED WITH OTHER SKINCARE INGREDIENTS?
Niacinamide's versatility is often considered to be one of its key benefits.
Not only is it generally compatible with other skincare ingredients, but niacinamide is typically well-tolerated for daily use—even by those with sensitive skin.
This means it can be used by multiple skin types and for a variety of concerns, such as dryness, flakiness, and blotchiness.



CAN ALL SKIN TYPES USE NIACINAMIDE?
Formulas with niacinamide are typically suitable for most skin types, including those with sensitive and blemish-prone skin.
For specific questions about your skin type, consult with a board-certified dermatologist for the best personalized advice.



WHAT TYPES OF SKINCARE PRODUCTS INCLUDE NIACINAMIDE?
Niacinamide is found in a variety of skincare products, including cleansers, lotions, facial toners, and creams.
Always use these products as directed, according to the product label.



CAN NIACINAMIDE BE USED ON BOTH THE FACE AND BODY?
Yes, niacinamide can be found in CeraVe products formulated to hydrate and help calm skin on both your face and body.
When choosing the ideal face or body product for your needs, we recommend looking for niacinamide products that are formulated specifically for your skin type and primary skin concerns.



AT WHAT AGE SHOULD I START USING NIACINAMIDE?
Because it offers a variety of benefits, niacinamide can be used to help target common skin concerns during any stage of life.
Niacinamide can be a helpful addition to an anti-aging skincare routine for mature skin due to its ability to help minimize the appearance of age-related skin concerns like wrinkles and skin discoloration.
Research shows that niacinamide might play an important role in helping your body build keratin, the main structural protein that helps keep skin looking firm and youthful.



HOW TO USE NIACINAMIDE IN YOUR SKINCARE ROUTINE
Reaping the benefits of niacinamide comes down to choosing gentle products that are formulated with dermatologists, fragrance-free, and suitable for your skin type.
It’s important to always apply your skincare products by following the instructions on the label.
Niacinamide can be used daily as part of a well-rounded skincare routine for healthy-looking skin at any age.
For example, to create a simple morning regimen that features niacinamide.



CHEMISTRY OF NIACINAMIDE:
The structure of Niacinamide consists of a pyridine ring to which a primary amide group is attached in the meta position.
Niacinamide is an amide of nicotinic acid.
As an aromatic compound, Niacinamide undergoes electrophilic substitution reactions and transformations of its two functional groups.
Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.



INDUSTRIAL PRODUCTION OF NIACINAMIDE:
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of Niacinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Niacinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014



BIOCHEMISTRY OF NIACINAMIDE:
Niacinamide, as a part of the cofactor Niacinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, Niacinamide is incorporated into NAD+ and Niacinamide adenine dinucleotide phosphate (NADP+).
NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.

If humans ingest Niacinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.
However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of Niacinamide.

NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the Niacinamide.
In NAD+, the nitrogen in the aromatic Niacinamide ring is covalently bonded to adenine dinucleotide.

The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.



BIOLOGICAL ROLE OF NIACINAMIDE:
Niacinamide occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Niacinamide is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Niacinamide can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.



FOOD SOURCES OF NIACINAMIDE:
Niacinamide occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Niacinamide is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Niacinamide is also available in higher doses.



RESEARCH:
A 2015 trial found niacinamide to reduce the rate of new nonmelanoma skin cancers and actinic keratoses in a group of people at high risk for the conditions.
Niacinamide has been investigated for many additional disorders, including treatment of bullous pemphigoid nonmelanoma skin cancers.

Niacinamide may be beneficial in treating psoriasis.
There is tentative evidence for a potential role of niacinamide in treating acne, rosacea, autoimmune blistering disorders, ageing skin, and atopic dermatitis.

Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.
ARCON (accelerated radiotherapy plus carbogen inhalation and Niacinamide) has been studied in cancer.
Research has suggested niacinamide may play a role in the treatment of HIV.



LET'S LOOK AT ALL THOSE SKIN BENEFITS:
#1: Anti-aging, wrinkle-smoothing properties:
With age, our skin tends to slow down in many ways.
One of them is in producing important proteins, such as keratin, filaggrin, and involucrin, at a slower rate.

Reduced amounts of these proteins results in poorer skin structure, reduced skin elasticity, and more wrinkles.
Studies show that niacinamide can boost collagen production as well as the production of these three important proteins.
That means improved skin structure and fewer wrinkles.

FYI, anti-aging studies usually use 4-5% niacinamide daily for 8-12 weeks, so if you are after the anti-aging benefits try to choose a product that tells you the exact percentage of niacinamide it contains.

#2: Skin-lightening properties:
Hyperpigmentation or brown spots are really stubborn and honestly it can be really hard to make them disappear just by topical products.
What you can expect for them is to fade a little and niacinamide is a great ingredient to help with that.
Studies show that 2-5% niacinamide used daily for 8 weeks results in significant lightening of hyperpigmentation.

When combined with amino sugar, acetyl glucosamine the results are even better.
What's more, niacinamide as a skin lightener works in a way different to most others.
It suppresses the transfer of melanosomes (little spheres carrying the melanin pigment) from melanocytes (skin cells producing the melanin) to keratinocytes (skin cells in the top layer of the skin) while most other skin lighteners block an enzyme called tyrosinase (that plays an important role in melanin production).

So if you want to mount a multi-front attack on the brown spots you can combine a niacinamide treatment with tyrosinase inhibitors like vitamin C, arbutin or kojic acid.

#3: Barrier repair functions: the skin barrier is the outer layer of the skin that is amazingly important at keeping the skin hydrated and healthy.
The stuff between the skin cells consists mainly of free fatty acids, cholesterol, and ceramides.
The amount and structure of these determine how healthy the skin barrier is.
What studies have shown is that 2% niacinamide can increase the synthesis of free fatty acids, cholesterol, and ceramides that result in healthier and stronger skin barrier, decreased trans-epidermal water loss and better hydrated skin.

#4: Anti-acne properties:
though niacinamide does not count as one of the gold standard anti-acne ingredients, if you have problem skin it's totally worth a try.
It has sebum regulating and anti-inflammatory properties and a study that used 4% niacinamide for 8 weeks to treat acne found that 82% of those treated showed some improvement.
What's more, the results were slightly better than with a 1% clindamycin gel, an antibiotics often used to treat acne.

#5: Other notable things:
if the above four things are not enough to convince you about niacinamide here are some more reasons! :)
Studies show that vitamin B3 can help to speed up epidermal cell growth (that slows down with age), it can help with wound healing, it can smooth the structure of the skin and it has also antibacterial and photo protective properties.
Plus, it might also be useful for rosacea and atopic dermatitis probably because of its anti-inflammatory property.



WHAT DOES NIACINAMIDE DO?
Niacinamide is a true multitasker.
From boosting hydration to protecting the skin from environmental damage, Niacinamide offers a wide variety of benefits.
Niacinamide penetrates your skin and helps renew your complexion from within.



SKIN BENEFITS OF NIACINAMIDE
Although Niacinamide may be less talked about than the wonder ingredient of the decade, retinol, its benefits are just as significant.
Here are some of the most amazing skin benefits of Niacinamide:
Increases the skin’s ability to maintain hydration.

Niacinamide strengthens your skin’s moisture barrier to improve its ability to hold on to moisture.
Your skin is less likely to dry out and will stay hydrated for longer.
If dry skin is a concern for you, check out our guide on how to tackle dry skin.

*Improves skin texture:
Niacinamide helps reduce the size of your pores while keeping your skin moisturised.

*Rejuvenates the eye area:
The skin around your eye is extremely delicate, and this is where usually the first signs of skin ageing appear.
Niacinamide can help with these skin concerns and reduce the appearance of fine lines and wrinkles for younger-looking eyes.

*Helps with dark spots and hyperpigmentation:
Niacinamide’s is a true multitasker, it can also help lighten dark spots and the marks of hyperpigmentation.

*Aids surface skin cell regeneration for younger-looking skin:
By locking in moisture, Niacinamide provides your skin with the moisture it needs for natural skin cell turnover to take place properly.

*Helps with oily skin:
Niacinamide helps regulate sebum production and this can help control oily skin.



WHAT DOES NIACINAMIDE DO FOR MY SKIN?
Niacinamide is a multipurpose skin care ingredient.
Niacinamide helps build keratin, a protein that maintains skin health.
Niacinamide’s also been shown to make your skin stronger, smoother and brighter.
“Niacinamide is used to treat acne and can help nourish and protect your skin, especially when it’s used with other products like retinol.
Niacinamide’s a potent nutrient that rarely has side effects.”



HERE ARE THE TOP SIX NIACINAMIDE BENEFITS:
1. Boost hydration
Niacinamide may enhance the function of your skin’s lipid barrier (a layer of water and oil that protects your skin).
This helps lock moisture in and keep pollutants or other potential irritants out, making your skin more hydrated and less sensitive.

2. Calm redness
Niacinamide has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema.
Niacinamide can also soothe irritation caused by strong exfoliants like retinol or glycolic acid that remove dead cells from the surface of your skin.

3. May reduce the appearance of pores
Nothing has been proven to reduce the actual size of your pores.
But niacinamide may help minimize their appearance by helping keep your skin smooth and clear.
Niacinamide also may help regulate the amount of oil your glands produce, which can prevent breakouts and clogged pores.

4. Possibly protect against skin cancer
Niacinamide is a close relative of another B vitamin called nicotinamide.
Oral Niacinamide supplements may help prevent new skin cancer or precancerous spots from developing in some people.
But more studies are needed to confirm this benefit.

A recent study also shows nicotinamide, the cousin of niacinamide, may increase the risk of triple-negative breast cancer in those who take the dietary supplement in high levels.
But using niacinamide in a skin care product and applying it topically is generally regarded as safe.

5. Treat dark spots:
Niacinamide is dermatologist-approved for brightening skin tone.
Some research suggests skin care formulas with 5% niacinamide can also help lighten dark spots.
In one small study, a combination of skin brighteners including retinol and niacinamide reduced dark spots and fine lines.
They also improved skin radiance and texture.

6. Reduce wrinkles and fine lines:
This vitamin’s antioxidant properties may help protect your skin and aid its recovery from damage due to factors like aging, sun and stress.
Some research has shown topical niacinamide can improve fine lines and wrinkles, as well as skin sallowness.



HOW DO I USE NIACINAMIDE IN MY SKIN CARE ROUTINE?
Niacinamide can be used once or twice daily after gentle cleansing during your regular skin care routine.
To maximize its benefits, apply niacinamide after applying a moisturizer.
You can also combine niacinamide serum with your moisturizer and apply them together to your face and neck.
Or try a face mask that contains niacinamide for skin recovery and relaxation.



HOW MUCH TO USE NIACINAMIDE:
Most skin care products contain 5% niacinamide or less, but amounts can vary.
Start slowly with a low concentration if you have sensitive skin.
And talk to your healthcare provider if you have any questions or concerns about how to use it or potential side effects.



PAIR NIACINAMIDE WITH OTHER PRODUCTS IN YOUR ROUTINE:
It’s often helpful to pair niacinamide with other skin care products to maximize its benefits.
These include anti-aging formulas with antioxidant vitamin C or moisturizers with ceramides (fat molecules), as well as:
*Glycolic acid.
*Hyaluronic acid.
*Retinol.
*Supplements, such as copper, folic acid and zinc.



HOW DOES NIACINAMIDE WORK IN SKIN?
Let the multi-tasking begin.
Niacinamide not only locks in moisture to support skin’s barrier, it also works to bring dull-looking skin back to life (read: brightens and revives).
Combined with our plant science and high-performing formulas, you get a multi-tasking essential for noticeably healthier-looking skin.



FUNCTIONS AND APPLICATIONS OF NIACINAMIDE:
1.The proper digestion and absorption of protein and fat;
2. To help in the essential amion acid tryptophan is converted to nicotinic acid;
3. To prevent all kinds of nerves, skin diseases;
4. Alleviate vomiting;
5. Promote the nucleic acid Synthesis, to prevent the aging of tissues and organs;
6. Lower the result of taking antidepressants caused by dry mouth and dysuria
7. Slow night muscle spasms, cramps paralysis and other symptoms of hand,foot and neuritis;
8. Is the natural the diuretic.
9. Treatment of congenital hypofunction of metabolism.



QUICK FACTS OF NIACINAMIDE:
A multi-functional skincare superstar with several proven benefits for the skin
Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis



HOW DOES NIACINAMIDE WORK?
If you’re wondering how niacinamide works on skin, then don’t look any further.
Niacinamide is a water-soluble vitamin, which means that it’s not naturally stored in the body.
Because of this, you’ll need to supplement your diet and the skincare you use.

When applied topically, niacinamide sinks into the skin to help reduce inflammation, shrink pores, and even skin tone and texture.
Can niacinamide be used with vitamin C or other ingredients?
The answer is, yes.
Niacinamide can be used with any other skincare ingredient and is often included in most formulas, thanks to the impressive roster of benefits it offers.



WHY SHOULD I USE NIACINAMIDE?
And here are some of those benefits.
Who needs niacinamide?
Put simply, anyone and everyone could benefit from adding niacinamide to their skincare routine.
Niacinamide helps to reduce acne, refine texture, reduce the size of pores, calm rosacea, enhance barrier function, smooth out pigmentation, reduce signs of ageing, and the list goes on.



NIACINAMIDE FOR SKIN CARE:
Niacinamide has been studied for several different skin issues.
*Acne treatment:
Researchers believe that niacinamide's anti-inflammatory effects can reduce the redness and inflammation caused by acne.

According to a review, topical (on the skin) niacinamide reduced acne.
The review also found that oral (by mouth) niacinamide and other supplements treated acne.
However, conclusions about using oral niacinamide alone for acne cannot be made.

*Aging skin:
According to a review, niacinamide increased keratin, an essential protein for healthy skin, in cell cultures.
Niacinamide may also help with other aspects of skincare, such as wrinkles and other signs of aging skin, using topical (skin) products.

*Melasma:
A skin condition that causes hyperpigmentation, or dark spots, melasma often occurs on unprotected skin regularly exposed to the sun.
According to a study, topical (skin) niacinamide cream reduced the appearance of dark spots in people with melasma.

*Skin cancer prevention:
In a randomized controlled trial, 12 months of treatment with 500 milligrams (mg) of niacinamide by mouth twice daily reduced the risk of developing new non-melanoma skin cancers, new squamous-cell carcinomas (skin cancer), and actinic keratosis (i.e., pre-skin cancer).

More high-quality studies are needed before using niacinamide for these conditions.
Always consult a healthcare provider specializing in skin health, such as a dermatologist, if you have developed a skin issue.
Self-treating with supplements or delaying diagnosis and treatment can make conditions worse.



WHAT DOES NIACINAMIDE DO FOR YOUR SKIN?
How you use niacinamide largely comes down to which skincare concerns you're looking to target.
Acne, rosacea and sensitivity:
Niacinamide’s anti-inflammatory properties make it an attractive option for those who suffer from rosacea and sensitivity – both the type that you’re born with, as well as temporary post-product irritation that manifests as redness and stinging.

If niacinamide is involved in most important cell functions, then there’s nothing it can’t cure, right?
Well, no—if every cellular process in our bodies could be perfected with vitamin supplements, we wouldn’t need antibiotics or radiation therapy.
That said, oral and topical niacinamide may have some actual benefits for skin health:

*Skin cancer prevention:
Ask a dermatologist what niacinamide does best, and the very first niacinamide benefit they’ll list is probably “skin cancer prevention.”
In a 2015 study in the New England Journal of Medicine, researchers gave 386 patients 500 mg of oral niacinamide or a placebo twice daily for a whole year.

All of the participants had at least two non-melanoma skin cancers within the previous five years and, therefore, were at a high risk for developing another skin cancer.
Results showed that during the study, there were 23% fewer new cases of skin cancer in the group that received niacinamide (336 cancers) compared to those who got the placebo (463 cancers).



NIACINAMIDE BENEFITS ON THE OTHER HAND?
Not so ordinary:
They include potentially improving all kinds of skin concerns, from acne to hyperpigmentation to signs of aging.
You might see niacinamide pop up in a topical product and in supplement form (we’ll explain the differences between the two and any potential side effects below) and wonder which one to choose.
If you aren’t quite sure what niacinamide is or what it’s doing in your moisturizer, you’re not alone.
Here’s what you should know about niacinamide benefits—and how to use niacinamide—before adding it to your skin-care routine.



PHYSICAL and CHEMICAL PROPERTIES of NIACINAMIDE:
CAS Number: 98-92-0
Molecular Weight: 122.12
Beilstein: 383619
EC Number: 202-713-4
MDL number: MFCD00006395
Physical state: crystalline
Color: white
Odor: odorless
Melting point/freezing point:
Melting point/range: 128 - 131 °C - lit.
Initial boiling point and boiling range: 150 - 160 °C at 0,0007 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 150 °C - closed cup
Autoignition temperature: not auto-flammable
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 500 g/l at 25 °C
Partition coefficient: n-octanol/water:
log Pow: -0,38 at 21 °C - Bioaccumulation is not expected.
Vapor pressure: No data available
Density: 1,40 g/cm3 at 25 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available



FIRST AID MEASURES of NIACINAMIDE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NIACINAMIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NIACINAMIDE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
- Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NIACINAMIDE:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NIACINAMIDE:
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed.
Dry.



STABILITY and REACTIVITY of NIACINAMIDE:
-Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
Niacinamide
Nicotinic acid amide
Pyridine-3-carboxylic acid amide
Vitamin B3
Vitamin PP
Pyridine-3-carboxylic acid amide
Nicotinic acid amide
Vitamin PP
Vitamin B3
Niacinamide

NICOTILAMIDE; NICOTINAMIDE; NIACINAMIDE, N° CAS : 98-92-0; Nom INCI : NIACINAMIDE. Nom chimique : 3-Pyridinecarboxamide. N° EINECS/ELINCS : 202-713-4. Ses fonctions (INCI) : Agent lissant : Diminue la rugosité ou les irrégularités pour rendre la peau uniforme. Noms français : 3-PYRIDINECARBOXAMIDE; ACETAMIDO-3 PYRIDINE; BETA-PYRIDINECARBOXAMIDE; CARBOXAMIDE-3 PYRIDINE; Niacinamide; NICOTILAMIDE; NICOTINAMIDE; VITAMINE PP. Noms anglais : 3-CARBAMOYLPYRIDINE; 3-PYRIDINECARBOXYLIC ACID AMIDE; NIACIN AMIDE; Niacinamide; NICOTINE ACID AMIDE; NICOTINE AMIDE; NICOTINIC ACID AMIDE; NICOTINIC AMIDE; PYRIDINE-3-CARBOXYLIC ACID AMIDE. Utilisation et sources d'émission: Vitamine (complexe b). 200-659-6 [EINECS]; 202-713-4 [EINECS]; 383619 [Beilstein]; 3-Pyridinecarboxamide [ACD/Index Name]; 98-92-0 [RN]; Dipigyl; MFCD00006395 [MDL number]; Niacinamide [USP] ;Nicotinamid [German] [ACD/IUPAC Name]; nicotinamida [Spanish]; Nicotinamide [ACD/IUPAC Name] [Wiki]; Nicotinamide [French] [ACD/IUPAC Name]; Nicotinamidum [Latin] ;Nicotinic acid amide; Pyridine-3-carboxamide; PYRIDINE-3-CARBOXYLIC ACID AMIDE; T6NJ CVZ [WLN]; Vi-noctyl; Vitamin B3; Vitamin- B3; Vitamin PP; Witamina PP; никотинамид [Russian] ; نيكوتيناميد [Arabic]; 烟酰胺 [Chinese]; 3-(Aminocarbonyl)pyridine; 3-Amidopyridine; 3-Carbamoylpyridine; 3-PYRIDINECARBOXYLIC ACID AMIDE; 6-Aminonicotinamide [ACD/IUPAC Name] Amid kyseliny nikotinove [Czech]; Aminicotin; Amixicotyn; Amnicotin; Austrovit PP; Benicot; b-Pyridinecarboxamide; Delonin amide; Dipegyl; endibion; Endobion; Enduramide; Factor; Factor pp ;Hansamid; Inovitan PP; m-(Aminocarbonyl)pyridine; Mediatric; meilun; NAM; Nandervit-N; NAP; NCA; Niacevit; Niacin amide; Niacotinamide; Niamide; Niavit PP; Nicamide; Nicamina; Nicamindon ; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosan 2; Nicosylamide; Nicota ; Nicotamide; Nicotilamide; Nicotililamido; Nicotine acid amide; nicotine amide; Nicotinic amide;Nicotinsaureamid [German]; Nicotol;Nicotylamide; Nicotylamidum; Nicovel; Nicovit; Nicovitina; nicovitinia; Nicovitol; Nicozymin; Niko-Tamin; Nikotinamid; Nikotinsaeureamid [German]; Niocinamide; Niozymin ; Papulex; Pelmin; Pelmine; Pelonin amide; PP-Faktor; ppHansamid; Propamine A; Pyridine, 3-carbamoyl-; pyridine-3-carboximidic acid; Savacotyl; VI-Nicotyl; vi-nivotyl; Vitamin B; Vitamin B3 amide; β-pyridinecarboxamide

Niacinamide (vitamin B3), also known as nicotinamide, is a form of vitamin B3 (niacin).
Its chemical formula is C6H6N2O, and it is a water-soluble compound.
Niacinamide (vitamin B3) is an essential nutrient that plays a crucial role in various biological processes in the human body.

CAS Number: 98-92-0
EC Number: 202-713-4



APPLICATIONS


Niacinamide (vitamin B3) is commonly used in dietary supplements to address vitamin B3 deficiencies and support overall health.
In the form of oral supplements, it can help improve skin health and alleviate certain dermatological conditions.
Niacinamide (vitamin B3) plays a crucial role in energy production and metabolic processes in the body.

Niacinamide (vitamin B3) is essential for the synthesis of coenzymes that aid in various biochemical reactions.
Niacinamide (vitamin B3) is used in skincare products for its wide range of benefits on the skin.

Niacinamide (vitamin B3) is known to improve the skin's moisture barrier, helping it retain water and stay hydrated.
Niacinamide (vitamin B3) can reduce the appearance of fine lines and wrinkles, making it a popular anti-aging ingredient.

Niacinamide (vitamin B3) is effective in addressing hyperpigmentation and uneven skin tone.
Niacinamide helps regulate sebum production, making it suitable for individuals with oily skin.

Niacinamide (vitamin B3) is used in sunscreen products to provide added UV protection and combat sun damage.
Niacinamide (vitamin B3) is a versatile ingredient in cosmetics and skincare formulations.
Niacinamide is recognized for its soothing effect on sensitive and irritated skin.

Niacinamide (vitamin B3) can minimize redness and inflammation associated with skin conditions like acne and rosacea.
Niacinamide (vitamin B3) can improve the overall texture and appearance of the skin, leading to a more even complexion.
Niacinamide (vitamin B3) is included in various topical formulations, including serums, creams, and lotions.

Its non-comedogenic properties make it suitable for individuals with acne-prone skin.
Niacinamide (vitamin B3) is often used in products targeting dry and dehydrated skin due to its hydrating effects.
Niacinamide (vitamin B3) can enhance the efficacy of other skincare ingredients when used in combination.
Niacinamide (vitamin B3) is known to reduce transepidermal water loss, helping maintain skin moisture.

Niacinamide (vitamin B3) is used in formulations to help combat environmental damage and pollution.
Niacinamide (vitamin B3) can support the repair of the skin's natural moisture barrier, particularly in individuals with compromised skin.
Niacinamide (vitamin B3)'s safety profile and versatility have led to its widespread use in the beauty industry.

In pharmaceuticals, Niacinamide may be included in certain medications and treatments for skin disorders.
Niacinamide (vitamin B3) is also used in some medical and therapeutic applications, such as wound care.
In summary, Niacinamide (vitamin B3) has a wide range of applications, from skincare and cosmetics to dietary supplements and pharmaceuticals, making it a versatile and beneficial compound in various industries.

Niacinamide (vitamin B3) is frequently used in the formulation of anti-aging skincare products due to its ability to reduce the appearance of wrinkles and fine lines.
Niacinamide (vitamin B3) is a versatile ingredient in moisturizers, helping to lock in hydration and prevent water loss from the skin.

In cosmetics, Niacinamide is used to create products that offer a smooth and even complexion.
Niacinamide (vitamin B3) is known to improve the appearance of enlarged pores and refine skin texture.

Niacinamide (vitamin B3) can be found in serums and lotions designed to brighten the skin and fade dark spots and pigmentation.
Niacinamide's soothing properties make it an effective ingredient in products for sensitive or redness-prone skin.

In dermatology, Niacinamide is used as a topical treatment for conditions like eczema and psoriasis.
Niacinamide (vitamin B3) can aid in the management of inflammatory skin conditions and provide relief from itching and discomfort.

Niacinamide (vitamin B3) is used in skincare routines to protect the skin from oxidative stress and free radical damage.
Niacinamide (vitamin B3) has anti-inflammatory properties that make it valuable for addressing conditions like acne and rosacea.
In the pharmaceutical industry, Niacinamide may be included in medications for hyperlipidemia and cardiovascular health.

Niacinamide (vitamin B3)'s role in cholesterol regulation contributes to its use in heart health supplements.
Niacinamide (vitamin B3) can be added to oral supplements to support overall health and well-being.
Niacinamide (vitamin B3) is used as a stable source of vitamin B3 in fortified foods and beverages.

In the food industry, it is used as a food additive and nutrient fortifier.
Niacinamide (vitamin B3) is employed in the manufacture of some hair care products to improve hair health and texture.
Niacinamide (vitamin B3) can be found in shampoos and conditioners designed to strengthen and nourish the hair.

Niacinamide's skin-barrier-supporting properties make it valuable in products for dry and dehydrated skin.
Niacinamide (vitamin B3) is sometimes included in after-sun products to soothe and repair sun-damaged skin.

In wound care, Niacinamide may be used to support the healing of minor cuts and burns.
Niacinamide (vitamin B3) is a key ingredient in some anti-itch creams and ointments for relieving skin discomfort.
Niacinamide (vitamin B3) is used in topical preparations for reducing inflammation and redness from insect bites and stings.

In veterinary medicine, Niacinamide can be included in pet supplements and products to support animal health.
Niacinamide (vitamin B3) is employed in certain industrial applications, such as corrosion inhibitors and coatings.
Niacinamide (vitamin B3) is known for its multifaceted benefits, making it a valuable ingredient in a wide range of products, from skincare and cosmetics to pharmaceuticals and beyond.
Niacinamide (vitamin B3) is an essential nutrient for the human body, participating in a variety of metabolic processes.

As a water-soluble vitamin, it cannot be stored in the body for long periods, so regular dietary intake is necessary.
Niacinamide (vitamin B3) is found naturally in foods like meat, fish, poultry, and enriched cereals.

Niacinamide (vitamin B3) is used in dietary supplements to address vitamin B3 deficiencies, which can lead to conditions like pellagra.
Niacinamide (vitamin B3) is crucial for the conversion of food into energy, supporting normal growth and development.
Niacinamide (vitamin B3) helps maintain the health of the skin, digestive system, and nervous system.

In the pharmaceutical industry, Niacinamide is used in the formulation of various medications and supplements.
Niacinamide (vitamin B3) is included in over-the-counter (OTC) products for its potential to support cardiovascular health.
Niacinamide (vitamin B3) may be part of treatments for high cholesterol and triglyceride levels.

In skincare, Niacinamide is included in a wide range of products, from cleansers to serums.
Niacinamide (vitamin B3) is used in products for individuals with sensitive skin, as it is less likely to cause irritation.
Niacinamide (vitamin B3)'s anti-inflammatory properties can help calm redness and soothe irritated skin.
Niacinamide (vitamin B3) is often incorporated into moisturizers, providing hydration without feeling heavy or greasy.

Niacinamide (vitamin B3) is known to improve the skin's barrier function, reducing water loss and strengthening the skin's defenses.
In cosmetics, it is found in foundations and concealers that offer a natural and radiant finish.
Niacinamide (vitamin B3) can be used in haircare products like conditioners to enhance hair health and shine.

In sunscreens, Niacinamide (vitamin B3) helps protect the skin from UV damage, making it a valuable addition to daily skincare routines.
Niacinamide (vitamin B3) is used in products targeting hyperpigmentation to even out skin tone and fade dark spots.
Niacinamide (vitamin B3) is included in products for individuals with oily skin to help control excess sebum production.

Niacinamide (vitamin B3) is employed in formulations designed to address the appearance of large pores and uneven texture.
Niacinamide (vitamin B3) is suitable for anti-aging products, aiding in the reduction of fine lines and wrinkles.
Niacinamide (vitamin B3) is often recommended by dermatologists to manage acne and minimize breakouts.

In cosmetics, Niacinamide can provide a soothing effect for individuals with skin conditions like rosacea.
Niacinamide (vitamin B3) is compatible with other skincare ingredients and can enhance their effectiveness.
Niacinamide (vitamin B3)'s versatility and safety profile have made it a popular and effective ingredient in both dietary supplements and a wide range of skincare and cosmetic products.
Niacinamide (vitamin B3) is an important cofactor in many enzymatic reactions within the body.
Niacinamide (vitamin B3) is necessary for the metabolism of carbohydrates, fats, and proteins.

In dietary supplements, it can be found in various forms, such as capsules, tablets, and liquid preparations.
Niacinamide (vitamin B3) supplements are often recommended for individuals with dietary deficiencies or specific health concerns.
Niacinamide (vitamin B3) plays a role in maintaining the proper function of the digestive system, including the production of stomach acid.
Niacinamide (vitamin B3)'s anti-inflammatory properties make it useful for addressing digestive conditions like gastritis.

In some pharmaceutical applications, Niacinamide is used in the treatment of diarrhea.
Niacinamide (vitamin B3) can help support healthy nerve function and reduce symptoms of nerve-related conditions.

Niacinamide (vitamin B3) is sometimes recommended for individuals with circulation issues to improve blood flow.
Niacinamide (vitamin B3) can assist in managing blood sugar levels, making it valuable for those with diabetes.
Niacinamide (vitamin B3) is used in eye drops and ophthalmic preparations to reduce intraocular pressure.

In veterinary medicine, it may be included in pet supplements to promote overall health.
Niacinamide (vitamin B3) is employed in agricultural and horticultural applications, as it can enhance plant growth and yield.

Niacinamide (vitamin B3) is used as a plant nutrient, either in its pure form or as a component of fertilizers.
Niacinamide (vitamin B3) can help improve the quality of crops and enhance their resistance to stressors.

In industrial settings, Niacinamide is used as a corrosion inhibitor to protect metals from rust and deterioration.
Niacinamide (vitamin B3) is an important ingredient in the manufacturing of coatings and paints.
Niacinamide (vitamin B3) is used in the production of inks for various applications, including printing and writing.

In the field of textiles, it can be found in dyeing and printing processes.
Niacinamide (vitamin B3)'s stability and compatibility make it suitable for use in a variety of chemical reactions.

In the cosmetic industry, it is used in the formulation of makeup products like foundations and powders.
Niacinamide (vitamin B3) is a key ingredient in haircare products to improve the health and appearance of hair.
Niacinamide (vitamin B3) can be found in some deodorants and antiperspirants for its skin-soothing properties.
Niacinamide (vitamin B3) is included in some topical medications for the treatment of inflammatory skin conditions.



DESCRIPTION


Niacinamide (vitamin B3), also known as nicotinamide, is a form of vitamin B3 (niacin).
Its chemical formula is C6H6N2O, and it is a water-soluble compound.
Niacinamide (vitamin B3) is an essential nutrient that plays a crucial role in various biological processes in the human body.

Niacinamide (vitamin B3) is often used in dietary supplements, skincare products, and medications.
In dietary supplements, Niacinamide (vitamin B3) is used to address niacin (vitamin B3) deficiencies and support overall health.
In skincare, niacinamide is popular for its beneficial effects on the skin, such as improving the skin barrier, reducing inflammation, and addressing issues like acne, hyperpigmentation, and fine lines.
Additionally, Niacinamide (vitamin B3) is sometimes used in pharmaceuticals and cosmetics for its therapeutic and cosmetic properties.

Niacinamide, also known as vitamin B3, is an essential nutrient for human health.
Niacinamide (vitamin B3) is one of the water-soluble B vitamins, along with other B-complex vitamins.

Niacinamide (vitamin B3) plays a vital role in various metabolic processes in the human body.
Niacinamide (vitamin B3) is involved in the synthesis of coenzymes that participate in energy production.
Niacinamide (vitamin B3) is crucial for DNA repair and maintenance.

Niacinamide (vitamin B3) is important for maintaining the health of the skin, nerves, and digestive system.
Niacinamide (vitamin B3) is found naturally in many foods, including meat, fish, and dairy products.
Niacinamide (vitamin B3) is often used to address vitamin B3 deficiencies in dietary supplements.

As a supplement, it can help support overall health and well-being.
In skincare, Niacinamide is recognized for its various beneficial effects on the skin.
Niacinamide (vitamin B3) is known for its anti-inflammatory properties, making it useful for addressing skin redness and irritation.
Niacinamide (vitamin B3) can improve the skin's moisture barrier, helping to retain moisture.

Niacinamide (vitamin B3) is effective in reducing the appearance of fine lines and wrinkles in cosmetics.
Niacinamide (vitamin B3) is used in skincare to address hyperpigmentation and uneven skin tone.
Niacinamide (vitamin B3) can help regulate sebum production, making it beneficial for individuals with oily skin.

Niacinamide (vitamin B3) is often included in sunscreen products for added UV protection.
Niacinamide (vitamin B3) is generally well-tolerated and suitable for a wide range of skin types.

Niacinamide (vitamin B3) is non-comedogenic, meaning it won't clog pores, making it suitable for acne-prone skin.
Niacinamide (vitamin B3) is known to have a soothing effect on sensitive and irritated skin.
Niacinamide (vitamin B3) can improve the overall texture and appearance of the skin with regular use.
Niacinamide (vitamin B3) is often used in cosmetic and skincare products in various concentrations.

Niacinamide (vitamin B3)'s stability and compatibility make it a versatile ingredient in the beauty industry.
Niacinamide (vitamin B3) is recognized for its role in promoting a healthy and radiant complexion.

Niacinamide (vitamin B3) supplements should be taken as directed, and excessive intake can lead to side effects.
In summary, Niacinamide (vitamin B3) is a versatile compound with important roles in nutrition, skincare, and overall health.



PROPERTIES


Physical Properties:

Chemical Formula: C6H6N2O
Molecular Weight: 122.12 g/mol
State: White crystalline powder
Solubility: Soluble in water and alcohol
Odor: Odorless
Taste: Bitter taste
Melting Point: 128-131°C (262-268°F)
Boiling Point: Decomposes at high temperatures
pH: Approximately neutral (pH 6-7)
Density: 1.40 g/cm³


Chemical Properties:

Niacinamide (vitamin B3) is a water-soluble vitamin and a derivative of niacin (nicotinic acid).
Niacinamide (vitamin B3) is stable in acidic and alkaline solutions, making it suitable for various formulations.
Niacinamide (vitamin B3) is not sensitive to light and heat, which contributes to its stability in cosmetic and pharmaceutical products.
Niacinamide (vitamin B3) is non-comedogenic, meaning it does not clog pores, making it suitable for individuals with acne-prone skin.
Niacinamide (vitamin B3) is well-tolerated and generally safe for topical and oral use.
Niacinamide (vitamin B3) can exist in various forms, such as capsules, tablets, creams, and serums.
Niacinamide's chemical structure includes an amide bond, making it a stable and non-acidic form of vitamin B3.



FIRST AID


Inhalation:

If Niacinamide dust or powder is inhaled and respiratory distress occurs, move the affected person to an area with fresh air.
Encourage the individual to breathe slowly and deeply.
If breathing difficulties persist, seek immediate medical attention.


Skin Contact:

In case of skin contact with Niacinamide, immediately remove contaminated clothing and shoes.
Rinse the affected area with plenty of lukewarm running water for at least 15 minutes.
Use mild soap if available to help remove Niacinamide from the skin.
Seek medical attention if skin irritation, redness, or signs of an allergic reaction (such as rash or hives) occur.


Eye Contact:

If Niacinamide comes into contact with the eyes, immediately rinse the eyes with gentle, lukewarm water for at least 15 minutes.
Hold the eyelids open and away from the eyeballs to ensure thorough irrigation.
Contact lenses should be removed if easily possible.
Seek immediate medical attention, especially if eye irritation, redness, pain, or vision problems persist.


Ingestion:

If Niacinamide is ingested and the person is conscious, do not induce vomiting.
Rinse the mouth with water if the individual is able to swallow and has no difficulty doing so.
Give the person a small amount of water to drink to dilute any remaining Niacinamide in the mouth.
Seek immediate medical attention, and provide information about the ingested amount and any symptoms experienced.


General First Aid Notes:

It's essential to consider individual tolerance and sensitivities when providing first aid. Allergic reactions can occur, even with substances considered safe.
Always use personal protective equipment (PPE) such as gloves and protective eyewear when handling chemicals.
In the event of exposure, provide the affected individual with as much information as possible about the nature of the exposure and the substance involved for medical evaluation and treatment.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
When handling Niacinamide, use appropriate PPE, including safety glasses or goggles, lab coat or protective clothing, and gloves.
Ensure that PPE is clean and in good condition.

Ventilation:
Work in a well-ventilated area to minimize exposure to dust or vapors.
Use local exhaust ventilation if available.

Avoid Skin and Eye Contact:
Prevent skin and eye contact by wearing suitable gloves and protective eyewear.
In case of accidental contact, follow the appropriate first aid measures.

Avoid Ingestion and Inhalation:
Do not eat, drink, smoke, or apply cosmetics in areas where Niacinamide is being handled.
Avoid inhaling Niacinamide dust or vapors.
Use a dust mask or respirator if necessary.

Prevent Contamination:
Do not touch your face, especially your eyes, nose, or mouth, with contaminated hands or gloves.
Use clean tools and equipment to handle Niacinamide to prevent contamination.

Labeling and Storage:
Clearly label containers that hold Niacinamide with appropriate hazard information, chemical name, and handling instructions.
Store Niacinamide away from incompatible materials.


Storage:

Location:
Store Niacinamide in a cool, dry, well-ventilated area.
Keep it away from direct sunlight and heat sources.

Temperature:
Maintain storage temperatures between 20°C and 25°C (68°F to 77°F).
Avoid temperature extremes.

Protection from Moisture:
Keep Niacinamide containers tightly sealed to prevent moisture absorption, as it can cause clumping and reduce the quality of the product.

Separation:
Store Niacinamide away from strong oxidizing agents, strong acids, and incompatible chemicals to avoid potential reactions.

Original Packaging:
Whenever possible, use the original, properly labeled packaging for Niacinamide.
This packaging is designed to protect the substance during storage.

Keep Out of Reach of Children:
Store Niacinamide in a location that is not accessible to children or unauthorized personnel.

Fire Precautions:
While Niacinamide is not flammable, take general fire precautions in the storage area and follow local regulations for fire safety.



SYNONYMS


Nicotinamide
Nicotinic acid amide
Nicotinylamide
3-Pyridinecarboxamide
Niacin amide
Vitamin PP
Nicomide
Nicotylamidum
Amide PP
Nicosan
Nictoamide
Pellagra preventive factor
Vitamin B3 amide
3-Carbamoylpyridine
Pyridine-3-carboxamide
Niacinamide riboside
Nicotinoyl amide
Nicotinyl amide
Nicotinylamide
Amide vitamin B3
Nicotinic amide
Nicotinic acid amide
Vitamin PP amide
Vitamin B3 (amid)
Niacinamide riboside chloride
3-Pyridineamide
Nicotinamidum
Nicotinic acid amide
Nicotinamid
Amide of Pyridine-3-carboxylic acid
Nicotinamidum
Niacinamid
Nicotinamide ribonucleoside
Amide PP
Nicotinic acid amide
Vitamin B3 amide
Nicotinic acid amide
3-Carbamoylpyridine
Nicotinoyl amide
Nicotinyl amide
3-Carbamoylpyridine
3-Pyridinecarboxylic acid amide
Nicotinoyl amide
Nicotinyl amide
Nicotinic amide
Pyridine-3-carboxamide
Pyridine-3-carboxylic acid amide
Niacinamide riboside chloride
Nicotinamide riboside chloride
Nicotinamide ribonucleoside

NICKEL CHLORIDE Nickel chloride Jump to navigationJump to search Nickel chloride Nickel chloride hexahydrate IUPAC name Nickel chloride Other names Infobox references Nickel chloride (or just nickel chloride), is the chemical compound NiCl2. The anhydrous salt is yellow, but the more familiar hydrate NiCl2·6H2O is green. Nickel chloride, in various forms, is the most important source of nickel for chemical synthesis. The nickel chlorides are deliquescent, absorbing moisture from the air to form a solution. Nickel salts have been shown to be carcinogenic to the lungs and nasal passages in cases of long-term inhalation exposure.[4] Contents 1 Production and syntheses 2 Structure of NiCl2 and its hydrates 3 Reactions 3.1 Coordination complexes 3.2 Applications in organic synthesis 3.3 Other uses 4 Safety 5 References 6 External links Production and syntheses The largest scale production of nickel chloride involves the extraction with hydrochloric acid of nickel matte and residues obtained from roasting refining nickel-containing ores. Nickel chloride is not usually prepared in the laboratory because it is inexpensive and has a long shelf-life. Heating the hexahydrate in the range 66-133.°C gives the yellowish dihydrate, NiCl2·2H2O.[5] The hydrates convert to the anhydrous form upon heating in thionyl chloride or by heating under a stream of HCl gas. Simply heating the hydrates does not afford the anhydrous dichloride. The dehydration is accompanied by a color change from green to yellow.[6] In case one needs a pure compound without presence of cobalt, nickel chloride can be obtained cautiously heating hexaamminenickel chloride:[7] Reactions Nickel chloride solutions are acidic, with a pH of around 4 due to the hydrolysis of the Ni2+ ion. Coordination complexes Color of various Ni(II) complexes in aqueous solution. From left to right, [Ni(NH3)6]2+, [Ni(en)3]2+, [NiCl4]2−, [Ni(H2O)6]2+ Most of the reactions ascribed to "nickel chloride" involve the hexahydrate, although specialized reactions require the anhydrous form. Crystals of hexammine nickel chloride Some nickel chloride complexes exist as an equilibrium mixture of two geometries; these examples are some of the most dramatic illustrations of structural isomerism for a given coordination number. For example, NiCl2(PPh3)2, containing four-coordinate Ni(II), exists in solution as a mixture of both the diamagnetic square planar and the paramagnetic tetrahedral isomers. Square planar complexes of nickel can often form five-coordinate adducts. NiCl2 is the precursor to acetylacetonate complexes Ni(acac)2(H2O)2 and the benzene-soluble (Ni(acac)2)3, which is a precursor to Ni(1,5-cyclooctadiene)2, an important reagent in organonickel chemistry. In the presence of water scavengers, hydrated Nickel chloride reacts with dimethoxyethane (dme) to form the molecular complex NiCl2(dme)2.[5] The dme ligands in this complex are labile. For example, this complex reacts with sodium cyclopentadienide to give the sandwich compound nickelocene. Hexammine nickel chloride complex is soluble when respective cobalt complex is not, which allows for easy separating of these close-related metals in laboratory conditions. Application of NiCl2 precatalyst. Other uses Nickel chloride solutions are used for electroplating nickel onto other metal items. Safety Nickel chloride is irritating upon ingestion, inhalation, skin contact, and eye contact. Prolonged inhalation exposure to nickel and its compounds has been linked to increased cancer risk to the lungs and nasal passages.[4] About Nickel chloride High purity Nickel chlorideChloride IonNickel Chloride is an excellent water soluble crystalline Nickel source for uses compatible with chlorides. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Nickel Chloride is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement. Nickel chloride Synonyms Nickel chloride anhydrous, Nickel dichloride, Nickelous chloride, Dichloronickel, Nickel(2+) chloride Nickel chloride (Ni) and water Nickel chloride and water: reaction mechanisms, environmental impact and health effects Seawater contains approximately 0.5-2 ppb of Nickel chloride, and rivers contain approximately 0.3 ppb. Phytoplankton contains 1-10 ppm Nickel chloride (dry mass), resulting in a 103-104 bioconcentration factor compared to seawater. Bentic algae can be found both in freshwater and salt water, and may contain between 0.2 and 84 ppm Nickel chloride. Lobsters contain 0.14-60 ppm Nickel chloride, molluscs 0.1-850 ppm, and fishes between 0.1 and 11 ppm (all values based on a dry mass). Nickel chloride occurs in water as Ni2+ (aq) and sometimes as NiCO3. It may be either dissolved, or complexed with inorganic ligands. Nickel chloride may also be bound to particles. In what way and in what form does Nickel chloride react with water? Under normal conditions Nickel chloride does not react with water. Solubility of Nickel chloride and Nickel chloride compounds Elementary Nickel chloride is water insoluble at T=20oC pressure = 1 bar. However, Nickel chloride compounds may be water soluble. Nickel chloride chloride is most water soluble; 553 g/L at 20oC, to 880 g/L at 99.9oC. Nickel chloride carbonate has a water solubility of 90 mg/L, whereas other Nickel chloride compounds, such as Nickel chloride oxide, Nickel chloride sulphide and Nickel chloride tetra carbonyl are water insoluble. Why is Nickel chloride present in water? Nickel chloride may be found in slate, sandstone, clay minerals and basalt. The main Nickel chloride source is pentlandite. The element accumulates in sediments and is a part of various biological cycles. Nickel chloride may end up in water from both point and non-point sources. Diffuse Nickel chloride emissions may stem from power plants, waste incinerators and metal industries. Nickel chloride is directly emitted from various industries through discharge on surface waters. It is applied in alloys for treatment of heavy metal polluted surface water, in Nickel chloride-cadmium batteries, as a catalyzer and as a pigment. Pure Nickel chloride is often applied as a protective coating on steel and copper objects. Nickel chloride-copper alloys have been applied in coins for a very long time. Other alloys are applied for kitchen ware, jewelry and turbine production. Nickel chloride may be applied as an anti-corrosive. Nickel chloride acetate is applied as a mordant in textile printing, and Nickel chloride carbonate is applied as a catalyzer for fat hardening and for ceramic paint production, as is Nickel chloride chloride. Nickel chloride tetra carbonyl is a by-product of Nickel chloride cleansing and is applied in various production processes. Nickel chloride compounds are also applied in agriculture. Phosphate fertilizers contain traces of Nickel chloride. Nickel chloride is often present in agricultural soils situated near fossil fuel industries. Organic matter often adsorbs Nickel chloride, causing coal and oil to contain traces of the element. Nickel chloride compounds may also be found in sludge, and in slags and fly ashes from waste incinerators. Better waste separation would prove useful, because Nickel chloride is up to 60% recyclable. What are the environmental effects of Nickel chloride in water? Nickel chloride is a dietary requirement for many organisms, but may be toxic in larger doses. Metallic Nickel chloride and some other Nickel chloride compounds are teratogenic and carcinogenic to mammals. Nickel chloride concentrations in plants are usually 1 μg/g, and concentrations above 50 μg/g are toxic. Tea has an extraordinary Nickel chloride content of 7.6 mg/kg dried leaves. Nickel chloride causes growth restraints in algae at concentrations of between 0.5 and 10 ppm. Fishes apparently are less susceptible to Nickel chloride, but this differs between species. For Daphnia hyaline the LD50 for 48 hours is 1.9 ppm. Chronic Nickel chloride toxicity for Daphnia magna lies between 30-150 ppb. The LD50 for marine lobsters lies between 150 and 300 ppm. In the organs of birds mainly living off water organisms Nickel chloride concentrations of 0.6-36 ppm (dry mass) were found. Nickel chloride accumulation in rats mainly occurs in lungs, where concentrations exceed those in other organs by 4-40 times. There are approximately 70 species of plants that accumulate extraordinarily high Nickel chloride concentrations. This may be up to 10,000 ppm (dry mass). For regular plant seed 0.5-2 ppm Nickel chloride in liquid substrates is considered toxic. Most plants have a relatively high Nickel chloride tolerance, but many species of grain are generally more susceptible. When water with a 40 ppm Nickel chloride concentration is added these grains may die. Liming of the soil may rapidly decrease Nickel chloride uptake. On the other hand, high Nickel chloride concentrations may throng other heavy metals. Sludge containing more than 200 ppm Nickel chloride (dry mass) may not be applied to agricultural soils. The five naturally occurring Nickel chloride isotopes are all stable. Eight other isotopes are considered instable. What are the health effects of Nickel chloride in water? The human body contains approximately 10 mg Nickel chloride. Nickel chloride is a dietary requirement for a number of organisms, therefore it might be of significance to humans. The human dietary need is estimated at only 5 μg, which is the result of a 150 μg intake. Nickel chloride probably has a function in urea to ammonia conversion by the urease enzyme. Nickel chloride cannot be resorbed in the digestive gland, unless it is complexed. Nickel chloride inhalation poses a greater risk than Nickel chloride in water. This may cause lung cancer, or nasal tumors. Nickel chloride carcinogenity is probably caused by Nickel chloride replacing zinc and magnesium ions on DNA-polymerase. These observations were mainly made in Nickel chloride working employees. Usually only smoking may cause this problem. Many people develop dermatitis upon skin contact with Nickel chloride. The same goes for Nickel chloride solutions. Nickel chloride allergies are more common among women than among men. Nickel chloride compounds may be toxic in high concentrations, but these are often water insoluble, limiting potential harm. For example, Nickel chloride tetra carbonyl is water insoluble, but is toxic and carcinogenic nevertheless. Upon intake of higher doses of Nickel chloride one usually vomits, resulting in rapid removal from the body. Which water purification technologies can be applied to remove Nickel chloride from water? Nickel chloride may be removed from water by means of active carbon adsorption. Coagulation is another feasible option. Nickel chloride only fully precipitates under certain conditions, namely a pH value of at least 9.5, under which it is fully converted to Nickel chloride hydroxide. Nickel chloride (or just nickel chloride), is the chemical compound NiCl2. The anhydrous salt is yellow, but the more familiar hydrate NiCl2·6H2O is green. Nickel chloride, in various forms, is the most important source of nickel for chemical synthesis. The nickel chlorides are deliquescent, absorbing moisture from the air to form a solution. Nickel salts have been shown to be carcinogenic to the lungs and nasal passages in cases of long-term inhalation exposure.[4] Contents 1 Production and syntheses 2 Structure of NiCl2 and its hydrates 3 Reactions 3.1 Coordination complexes 3.2 Applications in organic synthesis 3.3 Other uses 4 Safety 5 References 6 External links Production and syntheses The largest scale production of nickel chloride involves the extraction with hydrochloric acid of nickel matte and residues obtained from roasting refining nickel-containing ores. Nickel chloride is not usually prepared in the laboratory because it is inexpensive and has a long shelf-life. Heating the hexahydrate in the range 66-133.°C gives the yellowish dihydrate, NiCl2·2H2O.[5] The hydrates convert to the anhydrous form upon heating in thionyl chloride or by heating under a stream of HCl gas. Simply heating the hydrates does not afford the anhydrous dichloride. The dehydration is accompanied by a color change from green to yellow.[6] In case one needs a pure compound without presence of cobalt, nickel chloride can be obtained cautiously heating hexaamminenickel chloride:[7] Reactions Nickel chloride solutions are acidic, with a pH of around 4 due to the hydrolysis of the Ni2+ ion. Coordination complexes Color of various Ni(II) complexes in aqueous solution. From left to right, [Ni(NH3)6]2+, [Ni(en)3]2+, [NiCl4]2−, [Ni(H2O)6]2+ Most of the reactions ascribed to "nickel chloride" involve the hexahydrate, although specialized reactions require the anhydrous form. Crystals of hexammine nickel chloride Some nickel chloride complexes exist as an equilibrium mixture of two geometries; these examples are some of the most dramatic illustrations of structural isomerism for a given coordination number. For example, NiCl2(PPh3)2, containing four-coordinate Ni(II), exists in solution as a mixture of both the diamagnetic square planar and the paramagnetic tetrahedral isomers. Square planar complexes of nickel can often form five-coordinate adducts. NiCl2 is the precursor to acetylacetonate complexes Ni(acac)2(H2O)2 and the benzene-soluble (Ni(acac)2)3, which is a precursor to Ni(1,5-cyclooctadiene)2, an important reagent in organonickel chemistry. In the presence of water scavengers, hydrated Nickel chloride reacts with dimethoxyethane (dme) to form the molecular complex NiCl2(dme)2.[5] The dme ligands in this complex are labile. For example, this complex reacts with sodium cyclopentadienide to give the sandwich compound nickelocene. Hexammine nickel chloride complex is soluble when respective cobalt complex is not, which allows for easy separating of these close-related metals in laboratory conditions. Application of NiCl2 precatalyst. Other uses Nickel chloride solutions are used for electroplating nickel onto other metal items. Safety Nickel chloride is irritating upon ingestion, inhalation, skin contact, and eye contact. Prolonged inhalation exposure to nickel and its compounds has been linked to increased cancer risk to the lungs and nasal passages.[4] About Nickel chloride High purity Nickel chlorideChloride IonNickel Chloride is an excellent water soluble crystalline Nickel source for uses compatible with chlorides. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Nickel Chloride is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement. Nickel chloride Synonyms Nickel chloride anhydrous, Nickel dichloride, Nickelous chloride, Dichloronickel, Nickel(2+) chloride Nickel chloride (Ni) and water Nickel chloride and water: reaction mechanisms, environmental impact and health effects Seawater contains approximately 0.5-2 ppb of Nickel chloride, and rivers contain approximately 0.3 ppb. Phytoplankton contains 1-10 ppm Nickel chloride (dry mass), resulting in a 103-104 bioconcentration factor compared to seawater. Bentic algae can be found both in freshwater and salt water, and may contain between 0.2 and 84 ppm Nickel chloride. Lobsters contain 0.14-60 ppm Nickel chloride, molluscs 0.1-850 ppm, and fishes between 0.1 and 11 ppm (all values based on a dry mass). Nickel chloride occurs in water as Ni2+ (aq) and sometimes as NiCO3. It may be either dissolved, or complexed with inorganic ligands. Nickel chloride may also be bound to particles. In what way and in what form does Nickel chloride react with water? Under normal conditions Nickel chloride does not react with water. Solubility of Nickel chloride and Nickel chloride compounds Elementary Nickel chloride is water insoluble at T=20oC pressure = 1 bar. However, Nickel chloride compounds may be water soluble. Nickel chloride chloride is most water soluble; 553 g/L at 20oC, to 880 g/L at 99.9oC. Nickel chloride carbonate has a water solubility of 90 mg/L, whereas other Nickel chloride compounds, such as Nickel chloride oxide, Nickel chloride sulphide and Nickel chloride tetra carbonyl are water insoluble. Why is Nickel chloride present in water? Nickel chloride may be found in slate, sandstone, clay minerals and basalt. The main Nickel chloride source is pentlandite. The element accumulates in sediments and is a part of various biological cycles. Nickel chloride may end up in water from both point and non-point sources. Diffuse Nickel chloride emissions may stem from power plants, waste incinerators and metal industries. Nickel chloride is directly emitted from various industries through discharge on surface waters. It is applied in alloys for treatment of heavy metal polluted surface water, in Nickel chloride-cadmium batteries, as a catalyzer and as a pigment. Pure Nickel chloride is often applied as a protective coating on steel and copper objects. Nickel chloride-copper alloys have been applied in coins for a very long time. Other alloys are applied for kitchen ware, jewelry and turbine production. Nickel chloride may be applied as an anti-corrosive. Nickel chloride acetate is applied as a mordant in textile printing, and Nickel chloride carbonate is applied as a catalyzer for fat hardening and for ceramic paint production, as is Nickel chloride chloride. Nickel chloride tetra carbonyl is a by-product of Nickel chloride cleansing and is applied in various production processes. Nickel chloride compounds are also applied in agriculture. Phosphate fertilizers contain traces of Nickel chloride. Nickel chloride is often present in agricultural soils situated near fossil fuel industries. Organic matter often adsorbs Nickel chloride, causing coal and oil to contain traces of the element. Nickel chloride compounds may also be found in sludge, and in slags and fly ashes from waste incinerators. Better waste separation would prove useful, because Nickel chloride is up to 60% recyclable. What are the environmental effects of Nickel chloride in water? Nickel chloride is a dietary requirement for many organisms, but may be toxic in larger doses. Metallic Nickel chloride and some other Nickel chloride compounds are teratogenic and carcinogenic to mammals. Nickel chloride concentrations in plants are usually 1 μg/g, and concentrations above 50 μg/g are toxic. Tea has an extraordinary Nickel chloride content of 7.6 mg/kg dried leaves. Nickel chloride causes growth restraints in algae at concentrations of between 0.5 and 10 ppm. Fishes apparently are less susceptible to Nickel chloride, but this differs between species. For Daphnia hyaline the LD50 for 48 hours is 1.9 ppm. Chronic Nickel chloride toxicity for Daphnia magna lies between 30-150 ppb. The LD50 for marine lobsters lies between 150 and 300 ppm. In the organs of birds mainly living off water organisms Nickel chloride concentrations of 0.6-36 ppm (dry mass) were found. Nickel chloride accumulation in rats mainly occurs in lungs, where concentrations exceed those in other organs by 4-40 times. There are approximately 70 species of plants that accumulate extraordinarily high Nickel chloride concentrations. This may be up to 10,000 ppm (dry mass). For regular plant seed 0.5-2 ppm Nickel chloride in liquid substrates is considered toxic. Most plants have a relatively high Nickel chloride tolerance, but many species of grain are generally more susceptible. When water with a 40 ppm Nickel chloride concentration is added these grains may die. Liming of the soil may rapidly decrease Nickel chloride uptake. On the other hand, high Nickel chloride concentrations may throng other heavy metals. Sludge containing more than 200 ppm Nickel chloride (dry mass) may not be applied to agricultural soils. The five naturally occurring Nickel chloride isotopes are all stable. Eight other isotopes are considered instable. What are the health effects of Nickel chloride in water? The human body contains approximately 10 mg Nickel chloride. Nickel chloride is a dietary requirement for a number of organisms, therefore it might be of significance to humans. The human dietary need is estimated at only 5 μg, which is the result of a 150 μg intake. Nickel chloride probably has a function in urea to ammonia conversion by the urease enzyme. Nickel chloride cannot be resorbed in the digestive gland, unless it is complexed. Nickel chloride inhalation poses a greater risk than Nickel chloride in water. This may cause lung cancer, or nasal tumors. Nickel chloride carcinogenity is probably caused by Nickel chloride replacing zinc and magnesium ions on DNA-polymerase. These observations were mainly made in Nickel chloride working employees. Usually only smoking may cause this problem. Many people develop dermatitis upon skin contact with Nickel chloride. The same goes for Nickel chloride solutions. Nickel chloride allergies are more common among women than among men. Nickel chloride compounds may be toxic in high concentrations, but these are often water insoluble, limiting potential harm. For example, Nickel chloride tetra carbonyl is water insoluble, but is toxic and carcinogenic nevertheless. Upon intake of higher doses of Nickel chloride one usually vomits, resulting in rapid removal from the body. Which water purification technologies can be applied to remove Nickel chloride from water? Nickel chloride may be removed from water by means of active carbon adsorption. Coagulation is another feasible option. Nickel chloride only fully precipitates under certain conditions, namely a pH value of at least 9.5, under which it is fully converted to Nickel chloride hydroxide.

DESCRIPTION:
Niacinamide or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.
As a supplement, Nicotiamide (Niacinamide) is used by mouth to prevent and treat pellagra (niacin deficiency)
While nicotinic acid (niacin) may be used for this purpose, niacinamide has the benefit of not causing skin flushing.

CAS Number: 98-92-0
European Community (EC) Number: 202-713-4
IUPAC Name: pyridine-3-carboxamide
Molecular Formula: C6H6N2O



Nicotiamide (Niacinamide) is a white powder.
Nicotiamide (Niacinamide) is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a geroprotector.

Nicotiamide (Niacinamide) is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.
An important compound functioning as a component of the coenzyme NAD.
Its primary significance is in the prevention and/or cure of blacktongue and pellagra.

Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.



As a cream, Nicotiamide (Niacinamide) is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.
Nicotiamide (Niacinamide) is a water-soluble vitamin.
Nicotiamide (Niacinamide) is the supplement name, while nicotinamide is the scientific name.

Side effects of Nicotiamide (Niacinamide) are minimal.
At high doses, liver problems may occur.
Normal amounts are safe for use during pregnancy.

Niacinamide is in the vitamin B family of medications, specifically the vitamin B3 complex.
Nicotiamide (Niacinamide) is an amide of nicotinic acid.
Foods that contain Nicotiamide (Niacinamide) include yeast, meat, milk, and green vegetables.

Nicotiamide (Niacinamide) was discovered between 1935 and 1937.
Nicotiamide (Niacinamide) is on the World Health Organization's List of Essential Medicines.
Nicotiamide (Niacinamide) is available as a generic medication and over the counter.

Commercially, Nicotiamide (Niacinamide) is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries, grains have niacinamide added to them.


MEDICAL USES OF NICOTIAMIDE (NIACINAMIDE):
Niacin deficiency:
Nicotiamide (Niacinamide) is the preferred treatment for pellagra, caused by niacin deficiency.


Acne:
Nicotiamide (Niacinamide) cream is used as a treatment for acne.
Nicotiamide (Niacinamide) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Nicotiamide (Niacinamide) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.


The application of 2% topical Nicotiamide (Niacinamide) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Niacinamide has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.


Skin cancer:
Nicotiamide (Niacinamide) at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.


CHEMISTRY OF NICOTIAMIDE (NIACINAMIDE):
The structure of Nicotiamide (Niacinamide) consists of a pyridine ring to which a primary amide group is attached in the meta position.
Nicotiamide (Niacinamide) is an amide of nicotinic acid.
As an aromatic compound, it undergoes electrophilic substitution reactions and transformations of its two functional groups.


Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.
NAD+, the oxidized form of NADH, contains the nicotinamide moiety (highlighted in red)


INDUSTRIAL PRODUCTION OF NICOTIAMIDE (NIACINAMIDE):
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of nicotinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Nicotinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014.


BIOCHEMISTRY OF NICOTIAMIDE (NIACINAMIDE):
The active Nicotiamide (Niacinamide) group on the molecule NAD+ undergoes oxidation in many metabolic pathways.
Nicotiamide (Niacinamide), as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, nicotinamide is incorporated into NAD+ and nicotinamide adenine dinucleotide phosphate (NADP+).

NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.
If humans ingest nicotinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.

However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide.
NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the nicotinamide.


In NAD+, the nitrogen in the aromatic nicotinamide ring is covalently bonded to adenine dinucleotide.
The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.


BIOLOGICAL ROLE OF NICOTIAMIDE (NIACINAMIDE):
Nicotiamide (Niacinamide) occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Nicotiamide (Niacinamide) is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Nicotiamide (Niacinamide) can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.


FOOD SOURCES OF NICOTIAMIDE (NIACINAMIDE):
Nicotiamide (Niacinamide) occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Nicotiamide (Niacinamide) is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Nicotiamide (Niacinamide) is also available in higher doses

Niacinamide, also called nicotinamide, is a form of vitamin B3.
Nicotiamide (Niacinamide) is found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

Nicotiamide (Niacinamide) is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Unlike niacin, niacinamide doesn't help treat high cholesterol.


People use niacinamide to prevent vitamin B3 deficiency and related conditions such as pellagra.
Nicotiamide (Niacinamide) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

 




CHEMICAL AND PHYSICAL DATA OF NICOTIAMIDE (NIACINAMIDE):
Formula, C6H6N2O
Molar mass, 122.127 g•mol−1
Density, 1.40 g/cm3 g/cm3
Melting point, 129.5 °C (265.1 °F)
Boiling point, 334 °C (633 °F)
Molecular Weight
122.12 g/mol
-0.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
122.048012819 g/mol
Monoisotopic Mass
122.048012819 g/mol
Topological Polar Surface Area
56Ų
Heavy Atom Count
9
Formal Charge
0
Complexity
114
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point, 150 - 160 °C (0.0007 hPa)
Density, 1.40 g/cm3 (20 °C)
Flash point, 182 °C
Ignition temperature, 480 °C
Melting Point, 128 - 131 °C (sublimed)
pH value, 6.0 - 7.5 (50 g/l, H₂O, 20 °C)
Bulk density, 360 kg/m3
Solubility, 691 g/l
Assay (perchloric acid titration, calculated on dried substance), 99.0 - 101.0 %
Assay (HPLC, calc. on dried substance), 98.5 - 101.0 %
Identity (IR-spectrum) (Ph Eur), passes test
Identity (IR-spectrum) (USP), passes test
Identity (coloring 1), passes test
Identity (coloring 2), passes test
Identity (UV/VIS-Spectrum), passes test
Appearance, White to almost white, crystalline powder
Appearance of solution (50 g/l; water), Clear, colourless, not more intense in color than reference solution BY₇
pH (50 g/l; water), 6.0 - 7.5
Melting range (lower value), ≥ 128 °C
Melting range (upper value), ≤ 131 °C
Absorption ratio (A 245 nm/A 262 nm), 0.63 - 0.67
Chloride (Cl), ≤ 210 ppm
Sulfate (SO₄), ≤ 190 ppm
Heavy metals (as Pb) (JP), ≤ 30 ppm
As (Arsenic), ≤ 3 ppm
Cu (Copper), ≤ 20 ppm
Pb (Lead), ≤ 2 ppm
Zn (Zinc), ≤ 25 ppm
Residual solvents (ICH Q3C), excluded by production process
Readily carbonisable substance, passes test
Related substances (HPLC) (Major unspecified impurity), ≤ 0.10 %
Related substances (HPLC) (Sum of all impurities), ≤ 0.2 %
Sulfated ash (600 °C), ≤ 0.1 %
Loss on drying (Vacuum; 18 h), ≤ 0.5 %




SAFETY INFORMATION ABOUT NICOTIAMIDE (NIACINAMIDE):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






SYNONYMS OF NICOTIAMIDE (NIACINAMIDE):
3 Pyridinecarboxamide
3-Pyridinecarboxamide
B 3, Vitamin
B3, Vitamin
Enduramide
Jenapharm, Nicotinsäureamid
Niacinamide
Nicobion
Nicotinamide
Nicotinsäureamid Jenapharm
Papulex
Vitamin B 3
Vitamin B3
Vitamin PP
nicotinamide
niacinamide
98-92-0
3-Pyridinecarboxamide
Nicotinic acid amide
pyridine-3-carboxamide
vitamin PP
Aminicotin
Amixicotyn
Papulex
Nicotylamide
Endobion
Hansamid
Nicobion
Nikotinamid
Savacotyl
Benicot
Dipegyl
Pelmine
Nicotinic amide
Delonin amide
Pelonin amide
Austrovit PP
Vi-Nicotyl
Inovitan PP
Amnicotin
Nicamindon
Nicomidol
Nicosylamide
Nicotamide
Nicotilamide
Nicotililamido
Nicovitina
Nicovitol
Nicozymin
Niocinamide
Niacevit
Niamide
Nicamina
Nicasir
Nicofort
Nicogen
Nicotol
Nicovit
Niozymin
Nicota
Niko-tamin
3-Carbamoylpyridine
Nandervit-N
Nicotinamidum
Niavit PP
Nicosan 2
Nicotine amide
Nicotine acid amide
Nikotinsaeureamid
Pyridine-3-carboxylic acid amide
Vitamin B
Nicotylamidum
Nicotinsaureamid
beta-Pyridinecarboxamide
Pyridine, 3-carbamoyl-
Mediatric
Factor pp
m-(Aminocarbonyl)pyridine
3-Pyridinecarboxylic acid amide
Nicotinamida
Pelmin
Acid amide
Witamina PP
PP-Faktor
Amid kyseliny nikotinove
Amide PP
3-(aminocarbonyl)pyridine
Dipigyl
Niacinamid
Nicovel
Vitamin B (VAN)
CCRIS 1901
Nicotinsaureamid [German]
NAM
HSDB 1237
Nikotinsaeureamid [German]
Amid kyseliny nikotinove [Czech]
Nicotinamidum [INN-Latin]
Nicotinamida [INN-Spanish]
AI3-02906
NSC 13128
Nicotinamid
Nictoamide
Nicotinsaeureamid
3-Amidopyridine
Vi-noctyl
EINECS 202-713-4
NSC-13128
NSC-27452
b-Pyridinecarboxamide
Niacinamide (USP)
Niacinamide [USP]
UNII-25X51I8RD4
Nicotinamide [INN]
DTXSID2020929
CHEBI:17154
25X51I8RD4
Nicotinamide (Standard)
NSC13128
MFCD00006395
.beta.-Pyridinecarboxamide
Nicotinamide-(amide-15N)
Nicotinamide (Vitamin B3)
CHEMBL1140
DTXCID00929
MLS000069714
TPN COMPONENT NIACINAMIDE
EC 202-713-4
NIACINAMIDE COMPONENT OF TPN
NSC27452
NCGC00093354-03
NCGC00093354-05
SMR000058212
Nicotinamide 10 microg/mL in Acetonitrile
NIACINAMIDE (II)
NIACINAMIDE [II]
Niacinamide;Nicotinic acid amide;Vitamin B3
WLN: T6NJ CVZ
Nicotinamidum (INN-Latin)
Nicotinamida (INN-Spanish)
NIACINAMIDE (USP-RS)
NIACINAMIDE [USP-RS]
NICOTINAMIDE (MART.)
NICOTINAMIDE [MART.]
3 Pyridinecarboxamide
Niacinamide [USAN]
NICOTINAMIDE (EP IMPURITY)
NICOTINAMIDE [EP IMPURITY]
NIACINAMIDE (USP MONOGRAPH)
NIACINAMIDE [USP MONOGRAPH]
NICOTINAMIDE (EP MONOGRAPH)
NICOTINAMIDE [EP MONOGRAPH]
CAS-98-92-0
SR-01000721872
Niacotinamide
Nicosedine
Nicamid
nicotin-amide
Pahaba Control
Ultra Whitening
CellExosome HR
CellExosome SB
DEA No. 1405
Celonia CM
Ginseng Whitening
Dr. Cellmo
Royal GinsengCream
TOAS Rejuvenation
Nicotinamide,(S)
Vitamin B3 amide
Costem cell 5 N
Royal GinsengLotion
AAPE Skin Ampoule
CellExosome HE HR
Fantastic LightCream
Royal Ginseng Toner
Vita C Bright Serum
Vita C Bright Toner
Niacinamide Face Mask
Royal Ginseng Essence
Ultra Whitening Ample
TANIA PURECREAM
JUVEHEAL W Ampoule
Nicotinamidum (Latin)
BREXTEM S
NI-NICOTYL
Mediatric (Salt/Mix)
niacin - Vitamin B3
Dr. Color Effect Red
1yc5
DPC Aura Booster Mask
Dr Cellinme Mask Sheet
Opera_ID_775
Vita C Bright EyeCream
Miracle Laser Skin Mist
Niacin (as niacinamide)
Pyridine-3-carboxylamide
APLIN SPOT REMOVER
KARATICA I M CURE
NIACINAMIDE [FCC]
NICOTINAMIDE [MI]
TANIA PURE ESSENCE
VITA C BRIGHTCREAM
Pellagra-Preventing Factor
INTOMEDI HR PEPTIDE
NIACINAMIDE [HSDB]
NIACINAMIDE [INCI]
NICOTINAMIDE [JAN]
NYAAM NYAAM Vita Serum
RGO HYDRATION TONER
bmse000281
Miracle Moisturizer Essence
MolMap_000061
APLIN SPOT ALL KILL
MOISTIE PURE ESSENCE
NIACINAMIDE [VANDF]
DPC Whitening Booster Mask
SCHEMBL2926
AAPE Nutrient Facial Toner
Nicotinamide (JP17/INN)
NICOTINAMIDUM [HPUS]
NYAAM NYAAM Peptide Serum
Cellpium double essence toner
AAPE Continuous Renewal Mask
MLS001424246
Primerose Snail Hydro Essence
Shieldlife Whitening Ion Mask
Ultra V AQUA SHINE MASK
Ultra Whitening First Essence
NICOTINAMIDE [WHO-DD]
NICOTINAMIDE [WHO-IP]
by selected hyaluron day serum
Dr Cellinme Skin Care Ampoule
CELLPIUM REAL MASK PACK
Cellpium super richness ampoule
CAVIALL Wrinkle-Free PowerTox
Cellpium premiumEX hybrid toner
Revital Perfecting Dual Ampoule
SCHEMBL6278767
SGCUT00176
Daily Whitening Care Sheet Mask
Edge Cutimal Cat Whitening Mask
SCHEMBL19978192
BDBM27507
CELLBN MILKY TONE-UPCREAM
HY-B0150R
NYAAM NYAAM Skin Reborn Serum
A11HA01
Cellpium premiumEX hybrid essence
NIACINAMIDE [ORANGE BOOK]
BRIGHTUNING PEPTIDE AMPOULE
Nicotinamide, niacin, vitamin B3
HMS2052M21
HMS2090B05
HMS2093H03
HMS2236J03
HMS3370F21
HMS3394M21
HMS3655M20
HMS3713B22
HMS3884A16
Pharmakon1600-01505397
Ala-C Snail Cell Reparing Essence
AROCELL TIME REVERSE K I T
DR. GLODERM TABRX WHITENING
BCP07322
COSMEPURE BRIGHTENING CALMING
HY-B0150
THE SKIN HOUSE Vital BrightCream
THE SKIN HOUSE Vital BrightSerum
to_000073
ARILAC Brightening Mask Sheet Pack
Nicotinamide 1.0 mg/ml in Methanol
Nicotinamide, >=98.5% (HPLC)
Nicotinamide, >=99.5% (HPLC)
Tox21_111202
Tox21_201716
Tox21_302776
NICOTINAMIDUM [WHO-IP LATIN]
NSC759115
s1899
STL163867
THE SKIN HOUSE Vital Bright Toner
SFERANGS VITA C CAPSULEBOOSTER
AKOS005715850
Niveola P.H.c 3d Festival Mask Pack
Skin Project Ya Cooling Celluven Mask
THE SKIN HOUSE Vital BrightEmulsion
Tox21_111202_1
CCG-101149
CS-1968
DB02701
NC00399
NSC-759115
SB74497
Bk Cell 5days Of Secret Snow Whitening
EVECODE THREAD LIFTING MASK PACK
Nicotinamide 100 microg/mL in Methanol
Nicotinamide, >=98% (HPLC), powder
THE SKIN HOUSE Vital Bright Emulsion
THE SKIN HOUSE Vital Bright EyeCream
NCGC00093354-04
NCGC00093354-06
NCGC00093354-09
NCGC00256432-01
NCGC00259265-01
NIACIN (AS NIACINAMIDE) [VANDF]
AS-13845
BN166252
COSMEPURE BRIGHTENING CALMING TONER
DERLADIE HerbalExtract BodySolution MIST
Nicotinamide, puriss., 99.0-101.0%
SY024804
DR. GLODERM TIME TO WHITENING MASK
FRESH MANDARIN AROMATHERAPY MASK27g
Nicotinamide, tested according to Ph.Eur.
SBI-0206826.P001
AN ADC SP INTENSIVE MOISTURE ESSENCE
CS-0694823
Derma Pella Facial Cleanser for Normal Skin
DR.ALTHEA POWER WHITENING GLUTATHIONE
FT-0631517
FT-0672696
FT-0773644
MIZON ENJOY VITAL UP TIME Whitening Mask
N0078
SW197779-3
The Hayan Cherry Blossom Brightening Essence
EN300-15612
Niacinamide, meets USP testing specifications
C00153
D00036
DERMAHAN THE WHITENING MOISTURIZING MASK
Nicotinamide (Niacinamide), analytical standard
AB00373895-13
AB00373895_15
AB00373895_16
Derma Pella Cleanser for Sensitive and Dry Skin
Nicotinamide, Vetec(TM) reagent grade, >=98%
A845925
AC-907/25014114
AROCELL X BELLE J SUPER POWER CELL AMPOULE
J9 ULTRA ADVANCED INTENSIVE SCALP SERUM V2
Q192423
LEBODY LAB RENEWAL DUAL EFFECT PEPTIDE SERUM
Q-201470
SR-01000721872-3
SR-01000721872-4
SR-01000721872-5
LEBODY LAB RENEWAL DUAL EFFECT IDEBENONE SERUM
MUSTUS DAILY HARVEST SQUEEZE TONE UP MASK PACK
PAPA RECIPE BOMBEE BRIGHTENING HONEY MASK PACK
SISEUNDEUSI LUMINANT MASK PACK STEP2(WHITENING)
Z33546463
F2173-0513
Niacinamide;Nicotinic acid amide;Vitamin B3; Vitamin PP
Nicotinamide, British Pharmacopoeia (BP) Reference Standard
A186B02E-6C70-4E54-9739-79398D439AAA
Nicotinamide, European Pharmacopoeia (EP) Reference Standard
Niacinamide, United States Pharmacopeia (USP) Reference Standard
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Niacinamide, Pharmaceutical Secondary Standard; Certified Reference Material
Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture

DESCRIPTION:
Vitamin B3 or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.
As a supplement, Nicotiamide (Vitamin B3) is used by mouth to prevent and treat pellagra (niacin deficiency)
While nicotinic acid (niacin) may be used for this purpose, Vitamin B3 has the benefit of not causing skin flushing.

CAS Number: 98-92-0
European Community (EC) Number: 202-713-4
IUPAC Name: pyridine-3-carboxamide
Molecular Formula: C6H6N2O



Nicotiamide (Vitamin B3) is a white powder.
Nicotiamide (Vitamin B3) is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a geroprotector.

Nicotiamide (Vitamin B3) is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.
An important compound functioning as a component of the coenzyme NAD.
Its primary significance is in the prevention and/or cure of blacktongue and pellagra.

Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.



As a cream, Nicotiamide (Vitamin B3) is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.
Nicotiamide (Vitamin B3) is a water-soluble vitamin.
Nicotiamide (Vitamin B3) is the supplement name, while nicotinamide is the scientific name.

Side effects of Nicotiamide (Vitamin B3) are minimal.
At high doses, liver problems may occur.
Normal amounts are safe for use during pregnancy.

Vitamin B3 is in the vitamin B family of medications, specifically the vitamin B3 complex.
Nicotiamide (Vitamin B3) is an amide of nicotinic acid.
Foods that contain Nicotiamide (Vitamin B3) include yeast, meat, milk, and green vegetables.

Nicotiamide (Vitamin B3) was discovered between 1935 and 1937.
Nicotiamide (Vitamin B3) is on the World Health Organization's List of Essential Medicines.
Nicotiamide (Vitamin B3) is available as a generic medication and over the counter.

Commercially, Nicotiamide (Vitamin B3) is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries, grains have Vitamin B3 added to them.


MEDICAL USES OF NICOTIAMIDE (VITAMIN B3):
Niacin deficiency:
Nicotiamide (Vitamin B3) is the preferred treatment for pellagra, caused by niacin deficiency.


Acne:
Nicotiamide (Vitamin B3) cream is used as a treatment for acne.
Nicotiamide (Vitamin B3) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Nicotiamide (Vitamin B3) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.


The application of 2% topical Nicotiamide (Vitamin B3) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Vitamin B3 has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.


Skin cancer:
Nicotiamide (Vitamin B3) at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.


CHEMISTRY OF NICOTIAMIDE (VITAMIN B3):
The structure of Nicotiamide (Vitamin B3) consists of a pyridine ring to which a primary amide group is attached in the meta position.
Nicotiamide (Vitamin B3) is an amide of nicotinic acid.
As an aromatic compound, it undergoes electrophilic substitution reactions and transformations of its two functional groups.


Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.
NAD+, the oxidized form of NADH, contains the nicotinamide moiety (highlighted in red)


INDUSTRIAL PRODUCTION OF NICOTIAMIDE (VITAMIN B3):
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of nicotinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Nicotinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014.


BIOCHEMISTRY OF NICOTIAMIDE (VITAMIN B3):
The active Nicotiamide (Vitamin B3) group on the molecule NAD+ undergoes oxidation in many metabolic pathways.
Nicotiamide (Vitamin B3), as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, nicotinamide is incorporated into NAD+ and nicotinamide adenine dinucleotide phosphate (NADP+).

NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.
If humans ingest nicotinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.

However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide.
NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the nicotinamide.


In NAD+, the nitrogen in the aromatic nicotinamide ring is covalently bonded to adenine dinucleotide.
The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.


BIOLOGICAL ROLE OF NICOTIAMIDE (VITAMIN B3):
Nicotiamide (Vitamin B3) occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Nicotiamide (Vitamin B3) is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Nicotiamide (Vitamin B3) can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.


FOOD SOURCES OF NICOTIAMIDE (VITAMIN B3):
Nicotiamide (Vitamin B3) occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Nicotiamide (Vitamin B3) is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Nicotiamide (Vitamin B3) is also available in higher doses

Vitamin B3, also called nicotinamide, is a form of vitamin B3.
Nicotiamide (Vitamin B3) is found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

Nicotiamide (Vitamin B3) is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to Vitamin B3 when it is taken in amounts greater than what is needed by the body.
Unlike niacin, Vitamin B3 doesn't help treat high cholesterol.


People use Vitamin B3 to prevent vitamin B3 deficiency and related conditions such as pellagra.
Nicotiamide (Vitamin B3) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

 




CHEMICAL AND PHYSICAL DATA OF NICOTIAMIDE (VITAMIN B3):
Formula, C6H6N2O
Molar mass, 122.127 g•mol−1
Density, 1.40 g/cm3 g/cm3
Melting point, 129.5 °C (265.1 °F)
Boiling point, 334 °C (633 °F)
Molecular Weight
122.12 g/mol
-0.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
122.048012819 g/mol
Monoisotopic Mass
122.048012819 g/mol
Topological Polar Surface Area
56Ų
Heavy Atom Count
9
Formal Charge
0
Complexity
114
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point, 150 - 160 °C (0.0007 hPa)
Density, 1.40 g/cm3 (20 °C)
Flash point, 182 °C
Ignition temperature, 480 °C
Melting Point, 128 - 131 °C (sublimed)
pH value, 6.0 - 7.5 (50 g/l, H₂O, 20 °C)
Bulk density, 360 kg/m3
Solubility, 691 g/l
Assay (perchloric acid titration, calculated on dried substance), 99.0 - 101.0 %
Assay (HPLC, calc. on dried substance), 98.5 - 101.0 %
Identity (IR-spectrum) (Ph Eur), passes test
Identity (IR-spectrum) (USP), passes test
Identity (coloring 1), passes test
Identity (coloring 2), passes test
Identity (UV/VIS-Spectrum), passes test
Appearance, White to almost white, crystalline powder
Appearance of solution (50 g/l; water), Clear, colourless, not more intense in color than reference solution BY₇
pH (50 g/l; water), 6.0 - 7.5
Melting range (lower value), ≥ 128 °C
Melting range (upper value), ≤ 131 °C
Absorption ratio (A 245 nm/A 262 nm), 0.63 - 0.67
Chloride (Cl), ≤ 210 ppm
Sulfate (SO₄), ≤ 190 ppm
Heavy metals (as Pb) (JP), ≤ 30 ppm
As (Arsenic), ≤ 3 ppm
Cu (Copper), ≤ 20 ppm
Pb (Lead), ≤ 2 ppm
Zn (Zinc), ≤ 25 ppm
Residual solvents (ICH Q3C), excluded by production process
Readily carbonisable substance, passes test
Related substances (HPLC) (Major unspecified impurity), ≤ 0.10 %
Related substances (HPLC) (Sum of all impurities), ≤ 0.2 %
Sulfated ash (600 °C), ≤ 0.1 %
Loss on drying (Vacuum; 18 h), ≤ 0.5 %




SAFETY INFORMATION ABOUT NICOTIAMIDE (VITAMIN B3):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






SYNONYMS OF NICOTIAMIDE (VITAMIN B3):
3 Pyridinecarboxamide
3-Pyridinecarboxamide
B 3, Vitamin
B3, Vitamin
Enduramide
Jenapharm, Nicotinsäureamid
Vitamin B3
Nicobion
Nicotinamide
Nicotinsäureamid Jenapharm
Papulex
Vitamin B 3
Vitamin B3
Vitamin PP
nicotinamide
Vitamin B3
98-92-0
3-Pyridinecarboxamide
Nicotinic acid amide
pyridine-3-carboxamide
vitamin PP
Aminicotin
Amixicotyn
Papulex
Nicotylamide
Endobion
Hansamid
Nicobion
Nikotinamid
Savacotyl
Benicot
Dipegyl
Pelmine
Nicotinic amide
Delonin amide
Pelonin amide
Austrovit PP
Vi-Nicotyl
Inovitan PP
Amnicotin
Nicamindon
Nicomidol
Nicosylamide
Nicotamide
Nicotilamide
Nicotililamido
Nicovitina
Nicovitol
Nicozymin
Niocinamide
Niacevit
Niamide
Nicamina
Nicasir
Nicofort
Nicogen
Nicotol
Nicovit
Niozymin
Nicota
Niko-tamin
3-Carbamoylpyridine
Nandervit-N
Nicotinamidum
Niavit PP
Nicosan 2
Nicotine amide
Nicotine acid amide
Nikotinsaeureamid
Pyridine-3-carboxylic acid amide
Vitamin B
Nicotylamidum
Nicotinsaureamid
beta-Pyridinecarboxamide
Pyridine, 3-carbamoyl-
Mediatric
Factor pp
m-(Aminocarbonyl)pyridine
3-Pyridinecarboxylic acid amide
Nicotinamida
Pelmin
Acid amide
Witamina PP
PP-Faktor
Amid kyseliny nikotinove
Amide PP
3-(aminocarbonyl)pyridine
Dipigyl
Niacinamid
Nicovel
Vitamin B (VAN)
CCRIS 1901
Nicotinsaureamid [German]
NAM
HSDB 1237
Nikotinsaeureamid [German]
Amid kyseliny nikotinove [Czech]
Nicotinamidum [INN-Latin]
Nicotinamida [INN-Spanish]
AI3-02906
NSC 13128
Nicotinamid
Nictoamide
Nicotinsaeureamid
3-Amidopyridine
Vi-noctyl
EINECS 202-713-4
NSC-13128
NSC-27452
b-Pyridinecarboxamide
Vitamin B3 (USP)
Vitamin B3 [USP]
UNII-25X51I8RD4
Nicotinamide [INN]
DTXSID2020929
CHEBI:17154
25X51I8RD4
Nicotinamide (Standard)
NSC13128
MFCD00006395
.beta.-Pyridinecarboxamide
Nicotinamide-(amide-15N)
Nicotinamide (Vitamin B3)
CHEMBL1140
DTXCID00929
MLS000069714
TPN COMPONENT VITAMIN B3
EC 202-713-4
VITAMIN B3 COMPONENT OF TPN
NSC27452
NCGC00093354-03
NCGC00093354-05
SMR000058212
Nicotinamide 10 microg/mL in Acetonitrile
VITAMIN B3 (II)
VITAMIN B3 [II]
Vitamin B3;Nicotinic acid amide;Vitamin B3
WLN: T6NJ CVZ
Nicotinamidum (INN-Latin)
Nicotinamida (INN-Spanish)
VITAMIN B3 (USP-RS)
VITAMIN B3 [USP-RS]
NICOTINAMIDE (MART.)
NICOTINAMIDE [MART.]
3 Pyridinecarboxamide
Vitamin B3 [USAN]
NICOTINAMIDE (EP IMPURITY)
NICOTINAMIDE [EP IMPURITY]
VITAMIN B3 (USP MONOGRAPH)
VITAMIN B3 [USP MONOGRAPH]
NICOTINAMIDE (EP MONOGRAPH)
NICOTINAMIDE [EP MONOGRAPH]
CAS-98-92-0
SR-01000721872
Niacotinamide
Nicosedine
Nicamid
nicotin-amide
Pahaba Control
Ultra Whitening
CellExosome HR
CellExosome SB
DEA No. 1405
Celonia CM
Ginseng Whitening
Dr. Cellmo
Royal GinsengCream
TOAS Rejuvenation
Nicotinamide,(S)
Vitamin B3 amide
Costem cell 5 N
Royal GinsengLotion
AAPE Skin Ampoule
CellExosome HE HR
Fantastic LightCream
Royal Ginseng Toner
Vita C Bright Serum
Vita C Bright Toner
Vitamin B3 Face Mask
Royal Ginseng Essence
Ultra Whitening Ample
TANIA PURECREAM
JUVEHEAL W Ampoule
Nicotinamidum (Latin)
BREXTEM S
NI-NICOTYL
Mediatric (Salt/Mix)
niacin - Vitamin B3
Dr. Color Effect Red
1yc5
DPC Aura Booster Mask
Dr Cellinme Mask Sheet
Opera_ID_775
Vita C Bright EyeCream
Miracle Laser Skin Mist
Niacin (as Vitamin B3)
Pyridine-3-carboxylamide
APLIN SPOT REMOVER
KARATICA I M CURE
VITAMIN B3 [FCC]
NICOTINAMIDE [MI]
TANIA PURE ESSENCE
VITA C BRIGHTCREAM
Pellagra-Preventing Factor
INTOMEDI HR PEPTIDE
VITAMIN B3 [HSDB]
VITAMIN B3 [INCI]
NICOTINAMIDE [JAN]
NYAAM NYAAM Vita Serum
RGO HYDRATION TONER
bmse000281
Miracle Moisturizer Essence
MolMap_000061
APLIN SPOT ALL KILL
MOISTIE PURE ESSENCE
VITAMIN B3 [VANDF]
DPC Whitening Booster Mask
SCHEMBL2926
AAPE Nutrient Facial Toner
Nicotinamide (JP17/INN)
NICOTINAMIDUM [HPUS]
NYAAM NYAAM Peptide Serum
Cellpium double essence toner
AAPE Continuous Renewal Mask
MLS001424246
Primerose Snail Hydro Essence
Shieldlife Whitening Ion Mask
Ultra V AQUA SHINE MASK
Ultra Whitening First Essence
NICOTINAMIDE [WHO-DD]
NICOTINAMIDE [WHO-IP]
by selected hyaluron day serum
Dr Cellinme Skin Care Ampoule
CELLPIUM REAL MASK PACK
Cellpium super richness ampoule
CAVIALL Wrinkle-Free PowerTox
Cellpium premiumEX hybrid toner
Revital Perfecting Dual Ampoule
SCHEMBL6278767
SGCUT00176
Daily Whitening Care Sheet Mask
Edge Cutimal Cat Whitening Mask
SCHEMBL19978192
BDBM27507
CELLBN MILKY TONE-UPCREAM
HY-B0150R
NYAAM NYAAM Skin Reborn Serum
A11HA01
Cellpium premiumEX hybrid essence
VITAMIN B3 [ORANGE BOOK]
BRIGHTUNING PEPTIDE AMPOULE
Nicotinamide, niacin, vitamin B3
HMS2052M21
HMS2090B05
HMS2093H03
HMS2236J03
HMS3370F21
HMS3394M21
HMS3655M20
HMS3713B22
HMS3884A16
Pharmakon1600-01505397
Ala-C Snail Cell Reparing Essence
AROCELL TIME REVERSE K I T
DR. GLODERM TABRX WHITENING
BCP07322
COSMEPURE BRIGHTENING CALMING
HY-B0150
THE SKIN HOUSE Vital BrightCream
THE SKIN HOUSE Vital BrightSerum
to_000073
ARILAC Brightening Mask Sheet Pack
Nicotinamide 1.0 mg/ml in Methanol
Nicotinamide, >=98.5% (HPLC)
Nicotinamide, >=99.5% (HPLC)
Tox21_111202
Tox21_201716
Tox21_302776
NICOTINAMIDUM [WHO-IP LATIN]
NSC759115
s1899
STL163867
THE SKIN HOUSE Vital Bright Toner
SFERANGS VITA C CAPSULEBOOSTER
AKOS005715850
Niveola P.H.c 3d Festival Mask Pack
Skin Project Ya Cooling Celluven Mask
THE SKIN HOUSE Vital BrightEmulsion
Tox21_111202_1
CCG-101149
CS-1968
DB02701
NC00399
NSC-759115
SB74497
Bk Cell 5days Of Secret Snow Whitening
EVECODE THREAD LIFTING MASK PACK
Nicotinamide 100 microg/mL in Methanol
Nicotinamide, >=98% (HPLC), powder
THE SKIN HOUSE Vital Bright Emulsion
THE SKIN HOUSE Vital Bright EyeCream
NCGC00093354-04
NCGC00093354-06
NCGC00093354-09
NCGC00256432-01
NCGC00259265-01
NIACIN (AS VITAMIN B3) [VANDF]
AS-13845
BN166252
COSMEPURE BRIGHTENING CALMING TONER
DERLADIE HerbalExtract BodySolution MIST
Nicotinamide, puriss., 99.0-101.0%
SY024804
DR. GLODERM TIME TO WHITENING MASK
FRESH MANDARIN AROMATHERAPY MASK27g
Nicotinamide, tested according to Ph.Eur.
SBI-0206826.P001
AN ADC SP INTENSIVE MOISTURE ESSENCE
CS-0694823
Derma Pella Facial Cleanser for Normal Skin
DR.ALTHEA POWER WHITENING GLUTATHIONE
FT-0631517
FT-0672696
FT-0773644
MIZON ENJOY VITAL UP TIME Whitening Mask
N0078
SW197779-3
The Hayan Cherry Blossom Brightening Essence
EN300-15612
Vitamin B3, meets USP testing specifications
C00153
D00036
DERMAHAN THE WHITENING MOISTURIZING MASK
Nicotinamide (Vitamin B3), analytical standard
AB00373895-13
AB00373895_15
AB00373895_16
Derma Pella Cleanser for Sensitive and Dry Skin
Nicotinamide, Vetec(TM) reagent grade, >=98%
A845925
AC-907/25014114
AROCELL X BELLE J SUPER POWER CELL AMPOULE
J9 ULTRA ADVANCED INTENSIVE SCALP SERUM V2
Q192423
LEBODY LAB RENEWAL DUAL EFFECT PEPTIDE SERUM
Q-201470
SR-01000721872-3
SR-01000721872-4
SR-01000721872-5
LEBODY LAB RENEWAL DUAL EFFECT IDEBENONE SERUM
MUSTUS DAILY HARVEST SQUEEZE TONE UP MASK PACK
PAPA RECIPE BOMBEE BRIGHTENING HONEY MASK PACK
SISEUNDEUSI LUMINANT MASK PACK STEP2(WHITENING)
Z33546463
F2173-0513
Vitamin B3;Nicotinic acid amide;Vitamin B3; Vitamin PP
Nicotinamide, British Pharmacopoeia (BP) Reference Standard
A186B02E-6C70-4E54-9739-79398D439AAA
Nicotinamide, European Pharmacopoeia (EP) Reference Standard
Vitamin B3, United States Pharmacopeia (USP) Reference Standard
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Vitamin B3, Pharmaceutical Secondary Standard; Certified Reference Material
Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture