DESCRIPTION:

DMDEE (DIMORPHOLINODIETHYL ETHER) is suitable for water curing systems and is a strong foaming catalyst.
Due to the steric hindrance of amino groups, the storage period of NCO components can be prolonged.

CAS No.:6425-39-4
EC Number, 229-194-7
Chemical Name:2,2-Dimorpholinodiethylether
Molecular weight：244.33

SYNONYMS OF DMDEE (DIMORPHOLINODIETHYL ETHER) :
DMDEE;Niax« Catalyst DMDEE;4,4′-(oxydiethane-2,1-diyl)dimorpholine
Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-
Bis(2-morpholinoethyl) Ether, 4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine,2,2-Dimorpholinodiethylether,2,2'-Dimorpholinodiethyl ether,4,4'-(Oxydiethylene)bis(morpholine),4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine, 2,2'-Dimorpholinyldiethyl ether
4,4’-(oxydi-2,1-ethanediyl)bis-morpholin;Dimorpholinodiethylether;BIS(2-MORPHOLINOETHYL) ETHER;BIS[2-(N-MORPHOLINO)ETHYL] ETHER;LUPRAGEN(R) N 106;4,4'-(3-OXAPENTANE-1,5-DIYL)BISMORPHOLINE;4,4-(OXYDI-2,1-ETHANEDIYL)BISMORPHOLINE;2,2'-DIMORPHOLINODIETHYL ETHER



DMDEE (DIMORPHOLINODIETHYL ETHER) is suitable for the catalytic reaction of NCO and water in systems such as TDI, MDI, and IPDI; Sinocat® DMDEE is mainly used In one-component rigid polyurethane foam system, DMDEE (DIMORPHOLINODIETHYL ETHER) can also be used for polyether and polyester polyurethane soft foam, semi-rigid foam, CASE material, etc.
The addition amount accounts for 0.3-0.55% of the polyether/ester component.


DMDEE (DIMORPHOLINODIETHYL ETHER) is an acronym for dimorpholinodiethyl ether but is almost always referred to as DMDEE (pronounced dumdee) in the polyurethane industry.
DMDEE (DIMORPHOLINODIETHYL ETHER) is an organic chemical, specifically a nitrogen-oxygen heterocycle with tertiary amine functionality.

DMDEE (DIMORPHOLINODIETHYL ETHER) is a catalyst used mainly to produce polyurethane foam.
DMDEE (DIMORPHOLINODIETHYL ETHER) has the CAS number 6425-39-4 and is TSCA and REACH registered and on EINECS with the number 229-194-7.
The IUPAC name is 4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine and the chemical formula C12H24N2O3.

APPLICATIONS OF DMDEE (DIMORPHOLINODIETHYL ETHER) :
DMDEE (DIMORPHOLINODIETHYL ETHER) catalyst is a good blowing catalyst that does not cause cross-linking.
When used in moisture-cured systems, DMDEE (DIMORPHOLINODIETHYL ETHER) provides a stable prepolymer with a rapid cure.
DMDEE (DIMORPHOLINODIETHYL ETHER) can also be used in flexible polyester-based urethane foams, as well as semiflexible foams and HR molded foams.



USES OF DMDEE (DIMORPHOLINODIETHYL ETHER) :
DMDEE (DIMORPHOLINODIETHYL ETHER) tends to be used in one-component rather than 2-component polyurethane systems.
Its use has been investigated in polyurethanes for controlled drug release and also adhesives for medical applications.

Its use as a catalyst including the kinetics and thermodynamics have been studied and reported on extensively.
DMDEE (DIMORPHOLINODIETHYL ETHER) is a popular catalyst along with DABCO.






CHEMICAL AND PHYSICAL PROPERTIES OF DMDEE (DIMORPHOLINODIETHYL ETHER) :
Item, Standard
Appearance, Colorless transparent liquid
Chromaticity, ＜2
Water content, ≤0.1%
Content, ≥99%
Color Amber
Flash point, PMCC, °C (°F) 166 (330)
Freezing point, °C -28
Initial Boiling point, °C 309
pH 10.3
Specific gravity, 20/20°C 1.06
Vapor pressure, mm Hg, 20°C < 1
Viscosity, cSt, 15.5°C (60°F) 29
VOC Content, %, by ASTM D 2369 76
Water solubility, % > 10
CAS:, 6425-39-4
MF:, C12H24N2O3
MW:, 244.33
EINECS:, 229-194-7
Boiling point, 309 °C(lit.)
density, 1.06 g/mL at 25 °C(lit.)
refractive index, n20/D 1.484(lit.)
Fp, 295 °F
CAS DataBase Reference, 6425-39-4(CAS DataBase Reference)
EPA Substance Registry System, Morpholine, 4,4'-(oxydi-2,1-ethanediyl) bis-(6425-39-4)

Product Name:
Dimorpholinodiethyl ether
Other Name:
Morpholine,4,4′-(oxydi-2,1-ethanediyl)bis-;Morpholine,4,4′-(oxydiethylene)di-;4,4′-(Oxydi-2,1-ethanediyl)bis[morpholine];Bis(morpholinoethyl) ether;2,2′-Dimorpholinodiethyl ether;β,β′-Dimorpholinodiethyl ether;4,4′-(Oxydiethylene)bis[morpholine];4,4′-(Oxydiethylene)dimorpholine;Dimorpholinodiethyl ether;Texacat DMDEE;Jeffcat DMDEE;Di(2-morpholinoethyl) ether;PC CAT DMDEE;Bis[2-(4-morpholino)ethyl] ether;Dabco DMDEE;NSC 28749;U-CAT 660M;Bis(2-morpholinoethyl) ether;DMDEE;4,4′-(Oxydi-2,1-ethanediyl)bismorpholine;Lupragen N 106;N 106;JD-DMDEE;442548-14-3
CAS No.:
6425-39-4
Molecular Formula:
C12H24N2O3
InChIKeys:
InChIKey=ZMSQJSMSLXVTKN-UHFFFAOYSA-N
Molecular Weight:
244.33
Exact Mass:
244.33
EC Number:
229-194-7
UNII:
5BH27U8GG4
NSC Number:
28749
DSSTox ID:
DTXSID9042170
HScode:
2934999090
PSA:
34.2
XLogP3:
-0.6
Appearance:
Liquid
Density:
1.0682 g/cm3 @ Temp: 20 °C
Boiling Point:
176-182 °C @ Press: 8 Torr
Flash Point:
295 °F
Refractive Index:
1.482

SAFETY INFORMATION ABOUT DMDEE (DIMORPHOLINODIETHYL ETHER) :
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

DMDEE (Dimorpholinyldiethylether) is a 2,2’-dimorpholinodiethylether.
DMDEE (Dimorpholinyldiethylether) is a colorless to yellow liquid, with an amine-like odor.
DMDEE (Dimorpholinyldiethylether) is also miscible with water.


CAS Number: 6425-39-4
EC Number: 229-194-7
MDL number: MFCD00072740
Chemical name: 2,2-Dimorpholinodiethyl ether
Molecular Formula: C12H24N2O3



DMDEE, Nsc 28749, Einecs 229-194-7, 2,2-Dimorpholinodiet, Bis(morpholinoethyl)ether, 2,2-Dimorpholinodiethylether, 2,2'-DIMORPHOLINODIETHYL ET,
2,2-morpholinyl diethyl ether, 2,2-Dimorpholino Diethyl Ether, 2,2-dimorpholinyldiethyl ether, 2,2'-Dimorpholinodiethyl ether, 2,2'-dimorpholinyldiethyl ether, 4,4'-(Oxydiethylene)dimorpholine, 4,4'-(Oxydiethylene)bis(morpholine), Morpholine, 4,4'-(oxydiethylene)di-, 2,2'-Dimorpholinodiethylether (DMDEE), Nsc 28749, dimorpholine, Lupragen N106, Einecs 229-194-7, LUPRAGEN(R) N 106, 2,2-Dimorpholinodiet, Lupragen N106 (DMDEE), Dimorpholinodiethylether, Bis(morpholinoethyl)ether, Di(morpholinylethyl) ether, Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-, Bis(2-morpholinoethyl) Ether, 4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine, 2,2-Dimorpholinodiethylether, 2,2'-Dimorpholinodiethyl ether, 4,4'-(Oxydiethylene)bis(morpholine), 4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine, 2,2'-Dimorpholinyldiethyl ether, DMDEE, Nsc 28749, Einecs 229-194-7, 2,2-Dimorpholinodiet, Bis(morpholinoethyl)ether, 2,2-Dimorpholinodiethylether, 2,2'-DIMORPHOLINODIETHYL ET, 2,2-morpholinyl diethyl ether, 2,2-Dimorpholino Diethyl Ether, 2,2-dimorpholinyldiethyl ether, 2,2'-Dimorpholinodiethyl ether, 2,2'-dimorpholinyldiethyl ether, 4,4'-(Oxydiethylene)dimorpholine, 4,4'-(Oxydiethylene)bis(morpholine), Morpholine, 4,4'-(oxydiethylene)di-, 2,2'-Dimorpholinodiethylether (DMDEE), Morpholine,4,4′-(oxydi-2,1-ethanediyl)bis-, Morpholine,4,4′-(oxydiethylene)di-, 4,4′-(Oxydi-2,1-ethanediyl)bis[morpholine], Bis(morpholinoethyl) ether, 2,2′-Dimorpholinodiethyl ether, β,β′-Dimorpholinodiethyl ether, 4,4′-(Oxydiethylene)bis[morpholine], 4,4′-(Oxydiethylene)dimorpholine, Dimorpholinodiethyl ether, Texacat DMDEE, Jeffcat DMDEE, Di(2-morpholinoethyl) ether, PC CAT DMDEE, Bis[2-(4-morpholino)ethyl] ether, Dabco DMDEE, NSC 28749, U-CAT 660M, Bis(2-morpholinoethyl) ether, DMDEE, 4,4′-(Oxydi-2,1-ethanediyl)bismorpholine, Lupragen N 106, N 106, JD-DMDEE, 442548-14-3, 2,2-dimorpholinodiethylether, Jeffcat DMDEE, 2,2-morpholinyl diethyl ether, 2,2-dimorpholinyldiethyl ether, DMDEE, 2,2-Dimorpholino Diethyl Ether, 2,2-Dimorpholinodiethylether, 2,2'-Dimorpholinodiethyl ether, DMDEE, Bis(2-morpholinoethyl)ether, 6425-39-4, Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-, Bis(2-morpholinoethyl) Ether, 4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine, Dimorpholinodiethyl ether, 2,2-Dimorpholinodiethylether, 2,2'-Dimorpholinodiethyl ether, 4,4'-(Oxydiethylene)bis(morpholine), 4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine,
Bis(morpholinoethyl)ether, Morpholine, 4,4'-(oxydiethylene)di-, 5BH27U8GG4, DTXSID9042170, NSC-28749, .beta.,.beta.'-Dimorpholinodiethyl ether, 2,2'-Dimorpholinyldiethyl ether, 4,4'-(Oxydiethylene)bis[morpholine], DMDEE, UNII-5BH27U8GG4, 2,2'-Dimorpholinyldiethyl-ether, 4,4'-(Oxydiethylene)dimorpholine,
EINECS 229-194-7, NSC 28749, 4,4'-(Oxydi-2,1-ethanediyl)bismorpholine, bis(morpholinoethyl) ether, EC 229-194-7, 2,2'-dimorpholinodiethylether, 2,2-dimorpholinodiethyl ether, SCHEMBL111438, bis-(2-morpholinoethyl) ether, CHEMBL3187951, DTXCID7022170, Morpholine,4'-(oxydiethylene)di-, ZMSQJSMSLXVTKN-UHFFFAOYSA-N, Bis[2-(N-morpholino)ethyl] ether, DI(2-MORPHOLINOETHYL) ETHER, NSC28749, Tox21_301312, AC-374, MFCD00072740, AKOS015915238, Bis(2-morpholinoethyl) ether (DMDEE), NCGC00255846-01, AS-15429, 4,4'-(oxydiethane-2,1-diyl)dimorpholine, BIS(2-(4-MORPHOLINO)ETHYL) ETHER, CAS-6425-39-4, Morpholine,4'-(oxydi-2,1-ethanediyl)bis-, B1784, CS-0077139, FT-0636148, NS00005825, 4,4'-(3-Oxapentane-1,5-diyl)bismorpholine, Bis(2-morpholinoethyl) ether (DMDEE), 97%, D78314, 4,4'-(Oxydi-2,1-ethanediyl)bismorpholine, 97%, 4,4'-(2,2'-oxybis(ethane-2,1-diyl))dimorpholine, Q21034660,



DMDEE (Dimorpholinyldiethylether) is an amine based catalyst that is also known as dimorpholino-diethyl ether.
DMDEE (Dimorpholinyldiethylether) can act as a catalyst for blowing reactions and facilitates the process of polymeric curing.
DMDEE (Dimorpholinyldiethylether) is a strong foaming catalyst.


DMDEE (Dimorpholinyldiethylether) is a colorless to pale yellow liquid and is soluble in water.
DMDEE (Dimorpholinyldiethylether) is an amine catalyst suitable for water curing systems.
Due to the steric hindrance effect of amino groups, NCO-containing components can have a long storage period.


DMDEE (Dimorpholinyldiethylether) is one of the important polyurethane catalysts.
There are two methods for the synthesis of DMDEE (Dimorpholinyldiethylether): diethylene glycol and ammonia in the presence of hydrogen and metal catalysts, reacting at high temperature and high pressure to obtain bismorpholinyl diethyl ether; or diethylene glycol and morpholine in hydrogen and metal catalyst copper or cobalt.
In the presence of high temperature and high pressure reaction, bismorpholinyl diethyl ether is obtained.


The above two synthetic routes both use metals as catalysts and are generally gas-phase high-temperature and high-pressure reactions, which have disadvantages such as high production costs, difficult operation, and difficult product separation.
Uses dichloroethyl ether and morpholine as raw materials in the production of DMDEE (Dimorpholinyldiethylether), qualified products can be produced under mild conditions, with a product yield of 80% and a product purity of more than 99%.


DMDEE (Dimorpholinyldiethylether) is an acronym for dimorpholinodiethyl ether but is almost always referred to as DMDEE (pronounced dumdee) in the polyurethane industry.
DMDEE (Dimorpholinyldiethylether) is an organic chemical, specifically a nitrogen-oxygen heterocycle with tertiary amine functionality.


DMDEE (Dimorpholinyldiethylether) is a catalyst used mainly to produce polyurethane foam.
DMDEE (Dimorpholinyldiethylether) has the CAS number 6425-39-4 and is TSCA and REACH registered and on EINECS with the number 229-194-7.
The IUPAC name of DMDEE (Dimorpholinyldiethylether) is 4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine and the chemical formula C12H24N2O3.


DMDEE (Dimorpholinyldiethylether) is a chemical compound from the group of morpholines .
DMDEE (Dimorpholinyldiethylether) is a tertiary amine catalyst for the production of polyurethane foam, especially suitable for the manufacturing of polyester polyurethane foams or for the preparation of one component foams (OCF).


DMDEE (Dimorpholinyldiethylether) is a colorless to yellowish liquid, with an amine-like odor.
DMDEE (Dimorpholinyldiethylether) is also miscible with water.
DMDEE (Dimorpholinyldiethylether) is an amine based catalyst that is also known as dimorpholino-diethyl ether.


DMDEE (Dimorpholinyldiethylether) can act as a catalyst for blowing reactions and facilitates the process of polymeric curing.
DMDEE (Dimorpholinyldiethylether) is used catalyst paricularly suitable for on component polyurethane rigidfoam sealant systems.
DMDEE (Dimorpholinyldiethylether) is a reactive chemical agent that has been used as a sealant for the insulation and maintenance of joints.


DMDEE (Dimorpholinyldiethylether) is a 2,2’-dimorpholinodiethylether.
DMDEE (Dimorpholinyldiethylether) acts as a very selective blowing catalyst.
DMDEE (Dimorpholinyldiethylether) provides a stable prepolymer system.


DMDEE (Dimorpholinyldiethylether) is excellent for one-component systems.
Typical applications of DMDEE (Dimorpholinyldiethylether) include ether & ester based slabstock and high resilience (HR) molded flexible foams.



USES and APPLICATIONS of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
DMDEE (Dimorpholinyldiethylether) is a strong foamed catalyst,because of the steric resistance of the amino group,the components containing NCO can have a long storage period.
DMDEE (Dimorpholinyldiethylether) is mainly used for single component rigid polyurethane foam system, and also can be used for polyther and polyester polyurethane soft foam,semi-hard foam,CASE material.


DMDEE (Dimorpholinyldiethylether) is used catalyst particularly suitable for one component polyurethane rigid foam sealant systems.
DMDEE (Dimorpholinyldiethylether) is used as a blowing agent in the production of flexible, molded, and moisture-cured foams and coatings.
DMDEE (Dimorpholinyldiethylether) is also used in hot melt adhesives.


DMDEE (Dimorpholinyldiethylether) is mainly used for one-component rigid polyurethane foam systems, and can also be used for polyether and polyester polyurethane soft and semi-rigid foams.
DMDEE (Dimorpholinyldiethylether) is used as a catalyst in water-curing polyurethane compositions .


DMDEE (Dimorpholinyldiethylether) is a reactive chemical agent that has been used as a sealant for the insulation and maintenance of joints.
DMDEE (Dimorpholinyldiethylether) reacts with water vapor or moisture in the air, which causes it to harden.
DMDEE (Dimorpholinyldiethylether) is also known as DMDE and has been used in analytical chemistry as an optimal reagent for reactions with high resistance.


DMDEE (Dimorpholinyldiethylether) is a divalent hydrocarbon molecule with two hydroxy groups on its backbone.
The reaction products of DMDEE (Dimorpholinyldiethylether) are viscosity and reaction solution.
DMDEE (Dimorpholinyldiethylether) can be used in coatings due to its reactivity.


DMDEE (Dimorpholinyldiethylether) is used as a catalyst (or curing agent) in one-component polyurethane systems (e.g., one-component polyurethane caulk, one-component polyurethane foam, one-component polyurethane grouting materials, etc.).
Since one-component polyurethane prepolymers require long storage stability, di-morpholine-diethyl ether plays a key role in the stabilization and polymerization of polyurethane prepolymers, which also places extremely high demands on the quality of di-morpholine-diethyl ether products.


DMDEE (Dimorpholinyldiethylether) is used in polyurethane(PU) injection grouting for waterproof, one component foams,Polyurethane (PU) foam sealants,polyester polyurethane foams etc.
DMDEE (Dimorpholinyldiethylether) is a used Catalyst that is particularly suitable for one-component polyurethane rigid foam sealant systems.


DMDEE (Dimorpholinyldiethylether) used as excellent polyurethane catalyst (blowing agent) in one or too component rigid foam sealant system and flexible slabstock foams, it is suitable for curing system and vaporization system, it can guarantee a long storage period in MDI's prepolymer, mainly used in mono-component hard foam, adhesive and sealant etc.


DMDEE (Dimorpholinyldiethylether) is used as a initial product for chemical synthesis.
DMDEE (Dimorpholinyldiethylether) is suitable for water curing systems and is a strong foaming catalyst.
Due to the steric hindrance of amino groups, the storage period of NCO components can be prolonged.


It is suitable for the catalytic reaction of NCO and water in systems such as TDI, MDI, and IPDI; DMDEE (Dimorpholinyldiethylether) is mainly used.
In one-component rigid polyurethane foam DMDEE (Dimorpholinyldiethylether) it can also be used for polyether and polyester polyurethane soft foam, semi-rigid foam, CASE material, etc.
DMDEE (Dimorpholinyldiethylether) reacts with water vapor or moisture in the air, which causes it to harden. 2,2-Dimorpholinodiethyl ether is also known as


DMDE and has been used in analytical chemistry as an optimal reagent for reactions with high resistance.
DMDEE (Dimorpholinyldiethylether) is a divalent hydrocarbon molecule with two hydroxy groups on its backbone.
The reaction products of DMDEE (Dimorpholinyldiethylether) are viscosity and reaction solution.


DMDEE (Dimorpholinyldiethylether) can be used in coatings due to its reactivity.
DMDEE (Dimorpholinyldiethylether) is used catalyst for flexible polyester foams, molded foams, and moisture-cured foams and coatings.
DMDEE (Dimorpholinyldiethylether) is used good blowing catalyst that does not cause cross-linking.


-Use of DMDEE (Dimorpholinyldiethylether) as a polyurethane catalyst:
DMDEE (Dimorpholinyldiethylether) tends to be used in one-component rather than 2-component polyurethane systems.
DMDEE (Dimorpholinyldiethylether)'s use has been investigated in polyurethanes for controlled drug release and also adhesives for medical applications.
DMDEE (Dimorpholinyldiethylether)'s use as a catalyst including the kinetics and thermodynamics have been studied and reported on extensively.
DMDEE (Dimorpholinyldiethylether) is a popular catalyst along with DABCO.



EXTRACTION AND PRESENTATIN OF DMDEE (DIMORPHOLİNYLDİETHYLETHER):
DMDEE (Dimorpholinyldiethylether) is obtained by condensation of diethylene glycol with morpholine in the presence of a cobalt catalyst.



PHYSICAL and CHEMICAL PROPERTIES of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
CAS: 6425-39-4
EINECS: 229-194-7
InChI: InChI=1/C12H24N2O3/c1-7-15-8-2-13(1)5-11-17-12-6-14-3-9-16-10-4-14/h1-12H2
InChIKey: ZMSQJSMSLXVTKN-UHFFFAOYSA-N
Molecular Formula: C12H24N2O3
Molar Mass: 244.33
Density: 1.06 g/mL at 25 °C (lit.)
Melting Point: -28 °C
Boling Point: 309 °C (lit.)
Flash Point: 295°F
Water Solubility: 100g/L at 20℃
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
Vapor Presure: 66Pa at 20℃

Appearance: Oil
Color: Pale Brown to Light Brown
pKa: 6.92±0.10(Predicted)
Storage Condition: 2-8°C
Refractive Index: n20/D 1.484(lit.)
Melting point: -28 °C
Boiling point: 309 °C (lit.)
Density: 1.06 g/mL at 25 °C (lit.)
vapor pressure: 66 Pa at 20℃
refractive index: n20/D 1.484(lit.)
Flash point: 295 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Oil
pka: 6.92±0.10(Predicted)
color: Pale Brown to Light Brown

Viscosity: 216.6mm2/s
Water Solubility: 100g/L at 20℃
InChIKey: ZMSQJSMSLXVTKN-UHFFFAOYSA-N
LogP: 0.5 at 25℃
CAS DataBase Reference: 6425-39-4(CAS DataBase Reference)
FDA UNII: 5BH27U8GG4
EPA Substance Registry System: Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis- (6425-39-4)
Physical state: liquid
Color: yellow
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: 309 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,06 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Melting point: -28 °C
Boiling point: 309 °C (lit.)
Density: 1.06 g/mL at 25 °C (lit.)
vapor pressure: 66Pa at 20℃
refractive index: n20/D 1.484(lit.)

Flash point: 295 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Oil
pka: 6.92±0.10(Predicted)
color: Pale Brown to Light Brown
Water Solubility: 100g/L at 20℃
InChIKey: ZMSQJSMSLXVTKN-UHFFFAOYSA-N
LogP: 0.5 at 25℃
CAS DataBase Reference: 6425-39-4(CAS DataBase Reference)
EPA Substance Registry System: Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis- (6425-39-4)
Molecular Weight：244.33
Exact Mass：244.33
EC Number：229-194-7
UNII：5BH27U8GG4
NSC Number：28749
DSSTox ID：DTXSID9042170
HScode：2934999090

PSA：34.2
XLogP3：-0.6
Appearance：Liquid
Density：1.0682 g/cm3 @ Temp: 20 °C
Boiling Point：176-182 °C @ Press: 8 Torr
Flash Point：295 °F
Refractive Index：1.482
Density: 1.061g/cm3
Boiling point: 333.9°C at 760 mmHg
Refractive index: 1.481
Flash point: 96.7°C
Vapour Pressure: 0.000132mmHg at 25°C
Molecular Formula: C12H24N2O3
Molecular Weight: 244.3306
InChI: InChI=1/C12H24N2O3/c1-7-15-8-2-13(1)5-11-17-12-6-14-3-9-16-10-4-14/h1-12H2
CAS Registry Number: 6425-39-4
EINECS: 229-194-7

Molecular Weight: 244.33 g/mol
XLogP3-AA: -0.6
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 6
Exact Mass: 244.17869263 g/mol
Monoisotopic Mass: 244.17869263 g/mol
Topological Polar Surface Area :34.2Ų
Heavy Atom Count: 17
Formal Charge: 0
Complexity: 172
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
-Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Safety glasses with side-shields
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
-Precautions for safe handling:
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage class:
Storage class (TRGS 510): 12: Non Combustible Liquids



STABILITY and REACTIVITY of DMDEE (DIMORPHOLİNYLDİETHYLETHER):
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

DMDEE, or Dimethylaminoethoxyethanol, is a chemical compound commonly used as a catalyst in the production of polyurethane.
DMDEE (Polyurethane catalyst) belongs to the class of alkanolamines and is known for its effectiveness in facilitating various reactions involved in polyurethane synthesis.

CAS Number: 1707-42-6
EC Number: 216-900-8

Synonyms: DMDEE, Dimethylaminoethyl ether, N,N-Dimethylaminoethoxyethanol, Dimethylaminoethyl ether, Dimethylaminoethoxyethanol, Dimethylaminoethyl ethyl ether, Ethanol, 2-(dimethylamino)ethyl ether, 2-Dimethylaminoethyl ethyl ether, N,N-Dimethyl-2-aminoethanol ethyl ether, 2-(Dimethylamino)ethoxyethanol, Ethanol, 2-(dimethylamino)ethoxy-, Ethanol, 2-(dimethylamino)-1-(2-hydroxyethoxy)-, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl-, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether, Ethanol, 2-(dimethylamino)-1,2-dihydroxyethyl ether



APPLICATIONS


DMDEE (Polyurethane catalyst) is commonly used as a catalyst in the production of polyurethane foams.
DMDEE (Polyurethane catalyst) facilitates the reaction between polyols and isocyanates, essential for polyurethane polymerization.
DMDEE (Polyurethane catalyst) is utilized in the manufacture of both rigid and flexible polyurethane foams for insulation purposes.

DMDEE (Polyurethane catalyst) plays a crucial role in the production of polyurethane adhesives used in construction and automotive industries.
Dimethylaminoethoxyethanol is added to polyurethane coatings to enhance adhesion and flexibility.

DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane sealants for bonding and sealing applications.
DMDEE (Polyurethane catalyst) is employed in the production of polyurethane elastomers for various industrial applications.
DMDEE (Polyurethane catalyst) serves as a catalyst in the synthesis of polyurethane coatings and films for corrosion protection.

DMDEE (Polyurethane catalyst) is added to polyurethane adhesives for laminating and bonding applications.
DMDEE (Polyurethane catalyst) is utilized in the manufacture of polyurethane-based flooring materials for commercial and industrial use.

DMDEE is used in the formulation of polyurethane resins for casting and molding applications.
DMDEE (Polyurethane catalyst) plays a role in the production of polyurethane foam insulation for buildings and appliances.

DMDEE (Polyurethane catalyst) is added to polyurethane gels used in medical devices and wound care products.
DMDEE (Polyurethane catalyst) serves as a catalyst in the synthesis of polyurethane coatings for textile and fabric applications.
DMDEE (Polyurethane catalyst) is utilized in the production of polyurethane-based paints and coatings for decorative and protective purposes.

DMDEE (Polyurethane catalyst) is added to polyurethane adhesives for bonding wood, metal, plastic, and other materials.
DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane membranes for waterproofing and roofing applications.
DMDEE (Polyurethane catalyst) serves as a crosslinking agent in the production of thermoplastic polyurethane (TPU) materials.

DMDEE is employed in the formulation of polyurethane-based inkjet inks for printing on various substrates.
DMDEE (Polyurethane catalyst) plays a role in the production of polyurethane-based composites for automotive and marine applications.

DMDEE (Polyurethane catalyst) is utilized in the formulation of polyurethane foam insulation for refrigeration and HVAC systems.
DMDEE (Polyurethane catalyst) is added to polyurethane coatings for concrete and metal surfaces for protection against corrosion and abrasion.
DMDEE (Polyurethane catalyst) serves as a catalyst in the production of polyurethane-based foam mattresses and cushions.

DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane adhesives and sealants for the assembly of automotive components.
DMDEE (Polyurethane catalyst) is a versatile ingredient in the polyurethane industry, contributing to the production of a wide range of products with diverse applications across multiple sectors.

DMDEE (Polyurethane catalyst) is utilized in the production of polyurethane-based footwear, including shoe soles, insoles, and uppers.
DMDEE (Polyurethane catalyst) is added to polyurethane coatings for concrete floors to provide abrasion resistance and durability.

DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane adhesives for bonding laminates and veneers.
DMDEE (Polyurethane catalyst) serves as a catalyst in the production of polyurethane-based packaging materials, such as foam inserts and protective cushions.
DMDEE (Polyurethane catalyst) is employed in the formulation of polyurethane-based paints for automotive refinishing and industrial applications.

DMDEE (Polyurethane catalyst) is added to polyurethane sealants used in construction joints and expansion joints to prevent water infiltration.
DMDEE (Polyurethane catalyst) is utilized in the production of polyurethane-based synthetic leather for upholstery and fashion applications.

DMDEE (Polyurethane catalyst) serves as a curing agent in the production of polyurethane elastomers used in roller and conveyor belt manufacturing.
DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane coatings for concrete and metal tanks used in chemical storage.

DMDEE (Polyurethane catalyst) plays a role in the production of polyurethane foam filters for air purification and water treatment applications.
DMDEE (Polyurethane catalyst) is added to polyurethane adhesives for bonding insulation panels in refrigeration systems.

DMDEE (Polyurethane catalyst) is employed in the production of polyurethane-based soundproofing materials for acoustic insulation in buildings and vehicles.
DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane potting compounds for electrical and electronic encapsulation.
DMDEE (Polyurethane catalyst) serves as a catalyst in the production of polyurethane-based membranes for waterproofing tunnels and underground structures.

DMDEE (Polyurethane catalyst) is added to polyurethane coatings for metal surfaces to provide corrosion protection in marine environments.
DMDEE (Polyurethane catalyst) is utilized in the formulation of polyurethane foam mattresses and pillows for bedding applications.

DMDEE (Polyurethane catalyst) plays a role in the production of polyurethane-based adhesives for laminating decorative surfaces in furniture manufacturing.
DMDEE (Polyurethane catalyst) is added to polyurethane coatings for outdoor furniture to provide UV resistance and weatherability.

DMDEE (Polyurethane catalyst) is employed in the production of polyurethane-based medical devices such as catheters and wound dressings.
DMDEE (Polyurethane catalyst) serves as a catalyst in the production of polyurethane-based filters for automotive air and oil filtration systems.

DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane-based dental materials for restorative and prosthetic applications.
DMDEE (Polyurethane catalyst) is added to polyurethane sealants for joint sealing in concrete pavement and bridge decks.

DMDEE (Polyurethane catalyst) is employed in the production of polyurethane-based coatings for sports equipment such as helmets and pads.
DMDEE (Polyurethane catalyst) serves as a curing agent in the production of polyurethane adhesive tapes and films for packaging and bonding applications.
DMDEE (Polyurethane catalyst) is a versatile component in the polyurethane industry, enabling the development of innovative products with diverse applications across various sectors.

DMDEE (Polyurethane catalyst) is used in the production of polyurethane-based thermal insulation materials for appliances such as refrigerators and freezers.
DMDEE (Polyurethane catalyst) serves as a catalyst in the formulation of polyurethane-based coatings for metal surfaces in the automotive industry.
DMDEE (Polyurethane catalyst) is employed in the production of polyurethane adhesives for bonding composite materials in aerospace applications.

DMDEE (Polyurethane catalyst) is added to polyurethane sealants for caulking and waterproofing applications in construction.
DMDEE (Polyurethane catalyst) plays a role in the production of polyurethane-based membranes for waterproofing and damp-proofing building foundations.

DMDEE (Polyurethane catalyst) is utilized in the formulation of polyurethane-based coatings for wood surfaces, providing protection and aesthetic enhancement.
DMDEE (Polyurethane catalyst) is added to polyurethane foam insulation panels for energy-efficient building construction.

DMDEE (Polyurethane catalyst) serves as a curing agent in the production of polyurethane coatings for steel pipelines in the oil and gas industry.
DMDEE (Polyurethane catalyst) is employed in the formulation of polyurethane adhesives for bonding rubber components in the automotive and manufacturing sectors.
DMDEE (Polyurethane catalyst) plays a role in the production of polyurethane-based encapsulants for electronic components and printed circuit boards.

DMDEE (Polyurethane catalyst) is used in the formulation of polyurethane-based membranes for pond liners and water containment systems.
DMDEE (Polyurethane catalyst) serves as a catalyst in the production of polyurethane-based footwear, including athletic shoes and safety boots.

DMDEE (Polyurethane catalyst) is employed in the formulation of polyurethane-based coatings for architectural facades and building exteriors.
DMDEE (Polyurethane catalyst) is added to polyurethane adhesives for laminating decorative surfaces in interior design and furniture manufacturing.

DMDEE (Polyurethane catalyst) is used in the production of polyurethane-based coatings for marine vessels and offshore structures.
DMDEE (Polyurethane catalyst) serves as a curing agent in the formulation of polyurethane-based casting resins for sculpture and art restoration.

DMDEE (Polyurethane catalyst) is employed in the production of polyurethane-based insulation for pipes and tanks in industrial facilities.
DMDEE (Polyurethane catalyst) plays a role in the formulation of polyurethane adhesives for bonding stone and ceramic tiles in construction.

DMDEE (Polyurethane catalyst) is added to polyurethane foam mattresses for comfort and support in bedding applications.
DMDEE (Polyurethane catalyst) is utilized in the production of polyurethane-based sealants for joints and cracks in concrete pavements and bridges.
DMDEE (Polyurethane catalyst) serves as a catalyst in the formulation of polyurethane-based coatings for automotive interiors and trim components.

DMDEE (Polyurethane catalyst) is employed in the formulation of polyurethane-based adhesives for bonding leather and fabric in upholstery.
DMDEE (Polyurethane catalyst) is used in the production of polyurethane-based elastomers for industrial gaskets and seals.

DMDEE (Polyurethane catalyst) plays a role in the formulation of polyurethane coatings for playground equipment and outdoor structures.
DMDEE (Polyurethane catalyst) is a versatile component in the polyurethane industry, contributing to the development of innovative solutions for a wide range of applications across multiple sectors.

DMDEE (Polyurethane catalyst) is known for its effectiveness in improving the mechanical properties and durability of polyurethane products.
DMDEE (Polyurethane catalyst) is also utilized in pharmaceutical formulations as a solubilizing agent or stabilizer.

DMDEE finds applications in the textile industry for imparting wrinkle resistance or flame retardancy to fabrics.
In household and industrial cleaning products, it serves as a surfactant or solubilizing agent.

DMDEE (Polyurethane catalyst) is used in the production of cosmetics, toiletries, and personal care products for its emulsifying properties.
DMDEE (Polyurethane catalyst) is employed in the treatment of textiles to enhance dyeing processes and fabric softness.

DMDEE (Polyurethane catalyst) is compatible with a wide range of materials, making it suitable for various industrial applications.
DMDEE (Polyurethane catalyst) is stable under normal storage conditions but may degrade upon exposure to extreme pH, temperature, or light.

DMDEE (Polyurethane catalyst) is non-corrosive to most metals and materials, making it safe to handle.
DMDEE (Polyurethane catalyst) should be handled with care to avoid contact with skin, eyes, or mucous membranes.
In case of exposure, immediate rinsing with water is recommended to minimize potential irritation.
DMDEE (Polyurethane catalyst) should be stored in a cool, dry, well-ventilated area away from incompatible materials.

Proper labeling and container closure are essential to prevent contamination and accidental exposure.
Emergency spill control materials should be readily available in areas where DMDEE is handled.

Workers should be trained on safe handling practices and provided with appropriate personal protective equipment.
DMDEE (Polyurethane catalyst) is a versatile chemical compound with diverse industrial applications, contributing to the production of a wide range of products across various sectors.



DESCRIPTION


DMDEE, or Dimethylaminoethoxyethanol, is a chemical compound commonly used as a catalyst in the production of polyurethane.
DMDEE (Polyurethane catalyst) belongs to the class of alkanolamines and is known for its effectiveness in facilitating various reactions involved in polyurethane synthesis.

As a catalyst, DMDEE accelerates the reaction between polyols and isocyanates, which are the key components in polyurethane production.
This reaction leads to the formation of polyurethane polymers, which have a wide range of industrial applications due to their versatility, durability, and performance properties.

DMDEE (Polyurethane catalyst) plays a crucial role in promoting the curing and crosslinking reactions in polyurethane systems, contributing to the development of rigid and flexible foams, elastomers, coatings, adhesives, and sealants.
DMDEE (Polyurethane catalyst) helps improve the mechanical properties, such as strength, flexibility, and resilience, of the final polyurethane products.

DMDEE (Polyurethane catalyst) serves as an essential catalyst in the polyurethane industry, enabling the efficient and cost-effective production of a diverse range of polyurethane materials used in construction, automotive, aerospace, furniture, insulation, packaging, and other applications.

Dimethylaminoethoxyethanol, often abbreviated as DMDEE, is a clear and colorless liquid.
DMDEE (Polyurethane catalyst) has a faint, characteristic odor and is soluble in water and many organic solvents.
DMDEE (Polyurethane catalyst) possesses a molecular formula of C5H13NO2.

At room temperature, it exists as a liquid with a viscosity similar to water.
DMDEE (Polyurethane catalyst) contains carbon, hydrogen, nitrogen, and oxygen atoms.

DMDEE (Polyurethane catalyst) belongs to the class of alkanolamines due to its amine and ether functional groups.
DMDEE (Polyurethane catalyst) is commonly used as a catalyst in industrial processes, particularly in polyurethane foam production.

DMDEE (Polyurethane catalyst) facilitates the reaction between polyols and isocyanates, leading to the formation of polyurethane polymers.
DMDEE (Polyurethane catalyst) plays a crucial role in promoting the curing and crosslinking reactions in polyurethane coatings and adhesives.



PROPERTIES


Physical Properties:

Molecular Formula: C5H13NO2
Molecular Weight: 119.16 g/mol
Appearance: Clear, colorless liquid
Odor: Faint, characteristic odor
Density: 0.952 g/cm³ at 25°C
Melting Point: -60°C
Boiling Point: 166-168°C
Vapor Pressure: 1.5 mmHg at 25°C
Solubility in Water: Miscible
Solubility in Organic Solvents: Miscible with most organic solvents
pH: Typically neutral


Chemical Properties:

Chemical Structure: CH3OCH2CH2N(CH3)2
Functional Groups: Ether, Amine
Acidity/Basicity: Neutral pH, slight basic character
Reactivity: Reacts with isocyanates to form polyurethanes
Stability: Stable under normal conditions
Flammability: Not flammable
Flash Point: >100°C (closed cup)
Autoignition Temperature: Not determined
Oxidizing Properties: Not oxidizing
Corrosivity: Non-corrosive to most metals and materials



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air immediately while ensuring your own safety.
Assist the person in finding a comfortable breathing position and provide oxygen if available.
If breathing is difficult, administer artificial respiration. If breathing is absent, perform CPR.
Seek medical attention promptly. Transport the individual to a healthcare facility for further evaluation and treatment.
Keep the person warm and at rest while awaiting medical assistance.


Skin Contact:

Quickly remove contaminated clothing and shoes, taking care to avoid spreading the chemical.
Wash the affected area thoroughly with plenty of soap and water for at least 15 minutes.
Rinse skin under a gentle stream of water to ensure complete removal of the chemical.
If irritation persists or if skin appears damaged, seek medical attention immediately.
Protect the affected area from further exposure and cover with a clean, dry dressing.


Eye Contact:

Immediately flush the eyes with lukewarm, gently flowing water for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.
Remove contact lenses, if present and easily removable, during the flushing process.
Seek immediate medical attention or transport the person to an eye care professional for further evaluation and treatment.
Do not delay irrigation to remove contact lenses.


Ingestion:

Do not induce vomiting unless instructed to do so by medical personnel.
Rinse the mouth with water and encourage the affected person to drink plenty of water to dilute the chemical.
Seek immediate medical attention or contact a poison control center for further guidance.
Do not administer anything by mouth to an unconscious person.


Notes to Physician:

Provide the physician with information regarding the type and extent of exposure, including symptoms and duration.
Monitor the individual's vital signs and perform appropriate laboratory tests as necessary.
Treat symptoms and complications according to standard medical protocols.
Consider the possibility of delayed onset or prolonged effects from exposure to Dimethylaminoethoxyethanol.



HANDLING AND STORAGE


Handling:

When handling DMDEE, ensure that appropriate personal protective equipment (PPE) is worn, including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use in a well-ventilated area to minimize inhalation exposure. If ventilation is insufficient, use respiratory protection such as NIOSH-approved respirators.
Avoid skin contact and eye contact with DMDEE. In case of contact, promptly remove contaminated clothing and rinse skin or eyes with plenty of water.
Do not eat, drink, or smoke while handling DMDEE, and wash hands thoroughly after handling to prevent accidental ingestion.
Use suitable engineering controls such as local exhaust ventilation or containment to minimize exposure during handling and transfer operations.
Prevent spills and leaks by handling containers carefully and using appropriate transfer equipment. Have spill control measures and absorbent materials readily available.
Avoid contact with incompatible materials, including strong acids, oxidizing agents, and reactive metals.
Follow established procedures for safe handling, transfer, and disposal of DMDEE in accordance with applicable regulations and guidelines.
Train personnel on safe handling practices and emergency procedures in case of spills, leaks, or exposure incidents.
Keep containers tightly closed when not in use to prevent contamination and minimize evaporation.


Storage:

Store DMDEE in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and sources of ignition.
Store containers of DMDEE in a secure manner to prevent tipping, leaking, or damage.
Keep containers tightly closed to prevent contamination and minimize evaporation.
Store DMDEE away from incompatible materials, including strong acids, oxidizing agents, and reactive metals.
Ensure that storage areas are properly labeled with the appropriate hazard information and emergency contact numbers.
Check containers regularly for signs of damage or deterioration and replace as needed to prevent leaks or spills.
Provide adequate containment measures such as spill trays or secondary containment to prevent environmental contamination in the event of a spill or leak.
Store DMDEE in suitable containers made of compatible materials such as glass, stainless steel, or high-density polyethylene (HDPE).
Keep storage areas clean and free of clutter to facilitate safe handling and emergency response.
Monitor storage conditions regularly to ensure compliance with safety regulations and guidelines.

DMDEE Catalyst is an acronym for dimorpholinodiethyl ether but is almost always referred to as DMDEE (pronounced dumdee) in the polyurethane industry.
DMDEE Catalyst is an organic chemical, specifically a nitrogen-oxygen heterocycle with tertiary amine functionality.
DMDEE Catalyst is a catalyst used mainly to produce polyurethane foam.

CAS: 6425-39-4
MF: C12H24N2O3
MW: 244.33
EINECS: 229-194-7

Synonyms
2,2'-DIMORPHOLINODIETHYL ET;4,4'-(Oxydiethylene)bis(morpholine);Bis(morpholinoethyl)ether;Einecs 229-194-7;Morpholine, 4,4'-(oxydiethylene)di-;Nsc 28749;4,4'-(Oxydiethylene)dimorpholine;2,2-Dimorpholinodiet;Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-;Bis(2-morpholinoethyl) Ether;4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine;2,2-Dimorpholinodiethylether;2,2'-Dimorpholinodiethyl ether;4,4'-(Oxydiethylene)bis(morpholine);4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine;2,2'-Dimorpholinyldiethyl ether;6425-39-4;Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-;Bis(2-morpholinoethyl) Ether;4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine;Dimorpholinodiethyl ether;2,2-Dimorpholinodiethylether;2,2'-Dimorpholinodiethyl ether;4,4'-(Oxydiethylene)bis(morpholine);4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine;Bis(morpholinoethyl)ether;Morpholine, 4,4'-(oxydiethylene)di-;5BH27U8GG4;DTXSID9042170;NSC-28749;.beta.,.beta.'-Dimorpholinodiethyl ether
;2,2'-Dimorpholinyldiethyl ether;4,4'-(Oxydiethylene)bis[morpholine];DMDEE;UNII-5BH27U8GG4
;2,2'-Dimorpholinyldiethyl-ether;4,4'-(Oxydiethylene)dimorpholine;EINECS 229-194-7;NSC 28749
;4,4'-(Oxydi-2,1-ethanediyl)bismorpholine;bis(morpholinoethyl) ether;EC 229-194-7;2,2'-dimorpholinodiethylether;2,2-dimorpholinodiethyl ether;SCHEMBL111438;bis-(2-morpholinoethyl) ether;CHEMBL3187951;DTXCID7022170;Morpholine,4'-(oxydiethylene)di-;ZMSQJSMSLXVTKN-UHFFFAOYSA-N;Bis[2-(N-morpholino)ethyl] ether;DI(2-MORPHOLINOETHYL) ETHER;NSC28749;Tox21_301312;AC-374;MFCD00072740;AKOS015915238;Bis(2-morpholinoethyl) ether (DMDEE);NCGC00255846-01;AS-15429;4,4'-(oxydiethane-2,1-diyl)dimorpholine;BIS(2-(4-MORPHOLINO)ETHYL) ETHER;CAS-6425-39-4
;Morpholine,4'-(oxydi-2,1-ethanediyl)bis-;B1784;CS-0077139;FT-0636148;4,4'-(3-Oxapentane-1,5-diyl)bismorpholine;Bis(2-morpholinoethyl) ether (DMDEE), 97%;D78314;4,4'-(Oxydi-2,1-ethanediyl)bismorpholine, 97%;4,4'-(2,2'-oxybis(ethane-2,1-diyl))dimorpholine;Q21034660

DMDEE Catalystis an amine based catalyst that is also known as dimorpholino-diethyl ether.
DMDEE Catalyst can act as a catalyst for blowing reactions and facilitates the process of polymeric curing.
DMDEE Catalyst is an amine blowing catalyst.
DMDEE Catalystis 100% dimorpholinyldiethylether (DMDEE).
Used in rigid foam sealant systems as well as for flexible slabstock foams.
DMDEE Catalyst is suitable for processing by extrusion blow molding.
DMDEE Catalyst is a 2,2’-dimorpholinodiethylether.
Acts as a very selective blowing catalyst.
Provides a stable prepolymer system.
DMDEE Catalyst is excellent for one-component systems.
Typical applications of DMDEE Catalyst include ether & ester based slabstock and high resilience (HR) molded flexible foams.

DMDEE Catalyst is a reactive chemical agent that has been used as a sealant for the insulation and maintenance of joints.
DMDEE Catalyst reacts with water vapor or moisture in the air, which causes it to harden.
DMDEE Catalyst is also known as DMDE and has been used in analytical chemistry as an optimal reagent for reactions with high resistance.
DMDEE Catalyst is a divalent hydrocarbon molecule with two hydroxy groups on its backbone.
The reaction products of DMDEE Catalyst are viscosity and reaction solution.
DMDEE Catalyst can be used in coatings due to its reactivity.

DMDEE Catalyst Chemical Properties
Melting point: -28 °C
Boiling point: 309 °C (lit.)
Density: 1.06 g/mL at 25 °C (lit.)
Vapor pressure: 66Pa at 20℃
Refractive index: n20/D 1.484(lit.)
Fp: 295 °F
Storage temp.: 2-8°C
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
Form: Oil
pka: 6.92±0.10(Predicted)
Color: Pale Brown to Light Brown
Water Solubility: 100g/L at 20℃
InChIKey: ZMSQJSMSLXVTKN-UHFFFAOYSA-N
LogP: 0.5 at 25℃
CAS DataBase Reference: 6425-39-4(CAS DataBase Reference)
EPA Substance Registry System: DMDEE Catalyst (6425-39-4)

DMDEE Catalyst has the CAS number 6425-39-4 and is TSCA and REACH registered and on EINECS with the number 229-194-7.
The IUPAC name is DMDEE Catalyst and the chemical formula C12H24N2O3.

Uses
DMDEE Catalyst tends to be used in one-component rather than 2-component polyurethane systems.
DMDEE Catalyst's use has been investigated in polyurethanes for controlled drug release and also adhesives for medical applications.
DMDEE Catalyst's use as a catalyst including the kinetics and thermodynamics have been studied and reported on extensively.
DMDEE Catalyst is a popular catalyst along with DABCO.
Catalyst for flexible polyester foams, molded foams, and moisture-cured foams and coatings.
Good blowing catalyst that does not cause cross-linking.

Toxicity
DMDEE Catalyst has been in use for some time and so the toxicity is generally well understood. However, some sources say toxicity data is limited and work continues to acquire the necessary data and publish to ensure DMDEE Catalyst is in the public domain.

Catalyst for flexible polyester foams, molded foams, and moisture-cured foams and coatings.
DMDEE Polyurethane Grade is an amine based catalyst that is also known as dimorpholino-diethyl ether.
DMDEE Polyurethane Grade can act as a catalyst for blowing reactions and facilitates the process of polymeric curing.

CAS: 6425-39-4
MF: C12H24N2O3
MW: 244.33
EINECS: 229-194-7

Synonyms
2,2'-DIMORPHOLINODIETHYL ET;4,4'-(Oxydiethylene)bis(morpholine);Bis(morpholinoethyl)ether;Einecs 229-194-7;Morpholine, 4,4'-(oxydiethylene)di-;Nsc 28749;4,4'-(Oxydiethylene)dimorpholine;2,2-Dimorpholinodiet;Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-;Bis(2-morpholinoethyl) Ether;4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine;2,2-Dimorpholinodiethylether;2,2'-Dimorpholinodiethyl ether;4,4'-(Oxydiethylene)bis(morpholine);4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine;2,2'-Dimorpholinyldiethyl ether;6425-39-4;Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-;Bis(2-morpholinoethyl) Ether;4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine;Dimorpholinodiethyl ether;2,2-Dimorpholinodiethylether;2,2'-Dimorpholinodiethyl ether;4,4'-(Oxydiethylene)bis(morpholine);4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine;Bis(morpholinoethyl)ether;Morpholine, 4,4'-(oxydiethylene)di-;5BH27U8GG4;DTXSID9042170;NSC-28749;.beta.,.beta.'-Dimorpholinodiethyl ether
;2,2'-Dimorpholinyldiethyl ether;4,4'-(Oxydiethylene)bis[morpholine];DMDEE;UNII-5BH27U8GG4
;2,2'-Dimorpholinyldiethyl-ether;4,4'-(Oxydiethylene)dimorpholine;EINECS 229-194-7;NSC 28749
;4,4'-(Oxydi-2,1-ethanediyl)bismorpholine;bis(morpholinoethyl) ether;EC 229-194-7;2,2'-dimorpholinodiethylether;2,2-dimorpholinodiethyl ether;SCHEMBL111438;bis-(2-morpholinoethyl) ether;CHEMBL3187951;DTXCID7022170;Morpholine,4'-(oxydiethylene)di-;ZMSQJSMSLXVTKN-UHFFFAOYSA-N;Bis[2-(N-morpholino)ethyl] ether;DI(2-MORPHOLINOETHYL) ETHER;NSC28749;Tox21_301312;AC-374;MFCD00072740;AKOS015915238;Bis(2-morpholinoethyl) ether (DMDEE);NCGC00255846-01;AS-15429;4,4'-(oxydiethane-2,1-diyl)dimorpholine;BIS(2-(4-MORPHOLINO)ETHYL) ETHER;CAS-6425-39-4
;Morpholine,4'-(oxydi-2,1-ethanediyl)bis-;B1784;CS-0077139;FT-0636148;4,4'-(3-Oxapentane-1,5-diyl)bismorpholine;Bis(2-morpholinoethyl) ether (DMDEE), 97%;D78314;4,4'-(Oxydi-2,1-ethanediyl)bismorpholine, 97%;4,4'-(2,2'-oxybis(ethane-2,1-diyl))dimorpholine;Q21034660
Morpholine,4,4′-(oxydi-2,1-ethanediyl)bis-;Morpholine,4,4′-(oxydiethylene)di-;4,4′-(Oxydi-2,1-ethanediyl)bis[morpholine];Bis(morpholinoethyl) ether;2,2′-Dimorpholinodiethyl ether;β,β′-Dimorpholinodiethyl ether;4,4′-(Oxydiethylene)bis[morpholine];4,4′-(Oxydiethylene)dimorpholine;Dimorpholinodiethyl ether;Texacat DMDEE;Jeffcat DMDEE;Di(2-morpholinoethyl) ether;PC CAT DMDEE;Bis[2-(4-morpholino)ethyl] ether;Dabco DMDEE;NSC 28749;U-CAT 660M;Bis(2-morpholinoethyl) ether;DMDEE;4,4′-(Oxydi-2,1-ethanediyl)bismorpholine;Lupragen N 106;N 106;JD-DMDEE;442548-14-3

DMDEE Polyurethane Grade Chemical Properties
Melting point: -28 °C
Boiling point: 309 °C (lit.)
Density: 1.06 g/mL at 25 °C (lit.)
Vapor pressure: 66Pa at 20℃
Refractive index: n20/D 1.484(lit.)
Fp: 295 °F
Storage temp.: 2-8°C
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
Form: Oil
pka: 6.92±0.10(Predicted)
Color: Pale Brown to Light Brown
Water Solubility: 100g/L at 20℃
InChIKey: ZMSQJSMSLXVTKN-UHFFFAOYSA-N
LogP: 0.5 at 25℃
CAS DataBase Reference: 6425-39-4(CAS DataBase Reference)
EPA Substance Registry System: DMDEE Polyurethane Grade (6425-39-4)

Good blowing catalyst that does not cause cross-linking.
DMDEE Polyurethane Grade is an acronym for dimorpholinodiethyl ether but is almost always referred to as DMDEE (pronounced dumdee) in the polyurethane industry.
DMDEE Polyurethane Grade is an organic chemical, specifically a nitrogen-oxygen heterocycle with tertiary amine functionality.
DMDEE Polyurethane Grade is a catalyst used mainly to produce polyurethane foam.
DMDEE Polyurethane Grade has the CAS number 6425-39-4 and is TSCA and REACH registered and on EINECS with the number 229-194-7.
The IUPAC name is 4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine and the chemical formula C12H24N2O3.
DMDEE Polyurethane Grade has been in use for some time and so the toxicity is generally well understood.
However, some sources say toxicity data is limited and work continues to acquire the necessary data and publish to ensure DMDEE Polyurethane Grade is in the public domain.
DMDEE Polyurethane Grade is a tertiary amine catalyst for the production of polyurethane foam, especially suitable for the manufacturing of polyester polyurethane foams or for the preparation of one component foams (OCF)
DMDEE Polyurethane Grade is used in polyurethane(PU) injection grouting for waterproof, one component foams,Polyurethane (PU) foam sealants,polyester polyurethane foams etc.

Uses
DMDEE Polyurethane Grade tends to be used in one-component rather than 2-component polyurethane systems.
DMDEE Polyurethane Grade's use has been investigated in polyurethanes for controlled drug release and also adhesives for medical applications.
DMDEE Polyurethane Grade's use as a catalyst including the kinetics and thermodynamics have been studied and reported on extensively.
DMDEE Polyurethane Grade is a popular catalyst along with DABCO.
DMDEE Polyurethane Grade is a reactive chemical agent that has been used as a sealant for the insulation and maintenance of joints.
DMDEE Polyurethane Grade reacts with water vapor or moisture in the air, which causes it to harden.
DMDEE Polyurethane Grade is also known as DMDE and has been used in analytical chemistry as an optimal reagent for reactions with high resistance.
DMDEE Polyurethane Grade is a divalent hydrocarbon molecule with two hydroxy groups on its backbone.
The reaction products of DMDEE Polyurethane Grade are viscosity and reaction solution.
DMDEE Polyurethane Grade can be used in coatings due to its reactivity.

SYNONYMS 2-Aminoethoxyethanol; 2-(2-Hydroxyethoxy)ethylamine; Diglycolamine; 1-amino-3-oxapentane-5-ol; Ethanol, 2-(2-aminoethoxy)-; Diethylene glycol amine; Diethylene glycol monoamine; 2-Amino-2'-hydroxydiethyl ether; 3,6-dioxa-1-hexylamine; N-2-hydroxyethoxyethylamine; 2-(2-hydroxyethoxy)ethanamine; Ethanol,2-(2-aminoethoxy); 2,6-DIMETHYLTHIOPHENOL; 2-(2-amino-ethoxy)-ethanol; CAS NO:929-06-6

DMDM hydantoin is an antimicrobial formaldehyde releaser preservative.
DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.


CAS Number: 6440-58-0
EC Number: 229-222-8
INCI Name- Dimethyl Dimethylol Hydantoin
Chemical formula: C7H12N2O4



1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, 1,2-Dimethylol-5,6-dimethylhydantoine, Glydant, Dimethyloldimethyl hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-1,3-diazolidine-2,4-dione, 1,3-Dihydroxymethyl-5,5-dimethylhydantoin, 6440-58-0, 1,3-Bis(hydroxymethyl)-5,5 dimethylimidazolidine-2,4-dione, DMDM Hydantoin, Dimethyloldimethyl hydantoin, Glydant, Dmdmh, 1,3-Bis(hydroxymethyl)-5,5-dimethylhydantoin,
1,3-Dimethylol-5,5-dimethylhydantoin, Dantoin-DMDMH, Glycoserve-DMDMH, Dantoin dmdmh 55, Dimethylol-5,5-dimethylhydantoin, Dmdmh 55, Caswell No. 273AB,
dimethyloldimethylhydantoin, UNII-BYR0546TOW, 2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-, EINECS 229-222-8, BYR0546TOW, EPA Pesticide Chemical Code 115501, 1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, BRN 0882348, DTXSID8035217, HSDB 7488, 1,3-Di(hydroxymethyl)-5,5-dimethylhydantoin, DTXCID6015217, 1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN, EC 229-222-8, 1,3-DIHYDROXYMETHYL-5,5-DIMETHYLHYDANTOIN, Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-, MFCD00467199, DMDM HYDANTOIN (II), DMDM HYDANTOIN [II], Dantoguard, Dantion DMDMH 55, DMDM HYDANTION, 1,3-Dihydroxylmethyl-5,5-dimethylhydantoin, SCHEMBL69185, DMDM HYDANTOIN [INCI], DMDM HYDANTION [VANDF], DMDM HYDANTOIN [VANDF], DDAC0.6%, DDAC0.15%, WSDISUOETYTPRL-UHFFFAOYSA-N, Tox21_303842, AKOS006345746, n,n'-dimethylol-5,5-dimethylhydantoin, CS-W021276, USEPA/OPP Pesticide Code: 115501, NCGC00356947-01, AS-10924, SY101650, CAS-6440-58-0, FT-0606699, NS00007210, H11751, A834743, Q5205613, W-104844, 1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB], 1,3-Bis (hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, 1,3 BIS(HYDROXYMETHYL)-5,5- DIMETHYLHYDANTOINDIMETHYLHYDANTOIN, 1,3 BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOINDIMETHYLHYDANTOIN, 5-ethyl-1,3-dihydroxy-5-methyl-imidazolidine-2,4-dione;1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione,
DMDM Hydantoin; Dimethyloldimethylhydantoin, 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, 1,3-dimethylol-5,5-dimethyl hydantoin, 1,3-Bis (hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione butyl carbamate, Dimethylol dimethyl hydantoin, Dantoin DMDMH, DMDMH, Glydant, Mackstat DM, Nipaguard DMDMH, Paragon (mixture), 1,3-bis (hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, 1,3-dimethylol-5,5-dimethyl hydantoin, Dantoin dmdmh, Dimethyloldimethyl hydantoin, DMDMH, Glydant, Glydant Plus (95:5 mixture of DMDM hydantoin and Iodo propynyl butyl carbamate), Mackgard DM, Nipaguard DMDMH, Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, Bis(hydroxymethyl)-5,5-dimethylhydantoin, Dantion DMDMH 55, Dantoguard, Dimethylol-5,5-dimethylhydantoin, Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-, Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-, DMDM Hydantoin, T/N: Jeecide DMDM Hydantoin, T/N: Lanodent DM, T/N: Protacide DMDM H, Uniguard DMDM, Dantion DMDMH, Dantoguard, Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, Unidant G



DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, and skin care products.
DMDM hydantoin slowly releases formaldehyde and works as a preservative by making the environment less favorable to microorganisms.
DMDM hydantoin is a preservative and antimicrobial agent found in a wide range of cosmetics and skin-care and hair-care products.


DMDM hydantoin's considered a “formaldehyde donor.”
That means DMDM hydantoin releases a small amount of formaldehyde over time to help keep products fresh and free from contaminants.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative.


DMDM hydantoin is a shortened form of 1,3 dimethylolyl-5,5-dimethylhydantoin.
DMDM hydantoin is available as a white, crystalline solid.
DMDM hydantoin is also considered safe according to CIR and European standards.


Its mechanism of action is such that DMDM hydantoin slowly releases formaldehyde to perform an action such as antimicrobial or preservative.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM hydantoin is an organic compound belonging a class of compounds known as hydantoins.


DMDM hydantoin is a “formaldehyde donor,” which means that to work as a preservative and antimicrobial, it releases small levels of formaldehyde throughout the shelf-life of a personal care product or cosmetic products.
DMDM hydantoin is an organic compound that is a member of the hydantoin family.


DMDM hydantoin functions as an antimicrobial preservative by discharging formaldehyde.
DMDM hydantoin is an excellent preservative for both leave-on and rinse-off products such as shampoos, creams, lotions, bubble baths, rinses, wipes and towelettes.


DMDM hydantoin is easy to handle, very stable and cost-effective.
DMDM hydantoin is a crystal-like, odorless chemical often used in cosmetics as a preservative.
Several products contain DMDM hydantoin, from makeup and moisturizers to shampoos and conditioners.


DMDM hydantoin is a synthetic, formaldehyde-releasing preservative that has mixed research on its potential to aggravate skin.
DMDM hydantoin is a cosmetic preservative belonging to the formaldehyde-releasing agent family.
DMDM hydantoin is a clear colourless liquid with a mild odour and is one of the most commonly used preservative compounds in cosmetics.


DMDM Hydantoin is a broad-spectrum antimicrobial agent, effective against fungi, yeast, and gram-positive and gram-negative bacteria.
DMDM hydantoin helps personal care items stay fresh for long periods by stopping or slowing down the growth of potentially harmful fungi, yeast, and bacteria.


DMDM hydantoin has a high solubility in water and is considered a “formaldehyde donor", which means that it releases a small amount of formaldehyde overtime to help keep products fresh and free from contaminants.
DMDM hydantoinfunctions as a cost-effective and reliable preservative.


DMDM hydantoin is compatible over a wide pH range.
DMDM hydantoin possesses bacteriostatic properties and is stable in most formulations.
DMDM hydantoin has an ultra-low free formaldehyde content thereby avoiding the H350 phrase in Europe.


DMDM hydantoin is a clear water-white liquid with characteristic odor.
DMDM hydantoin is a clear, aqueous preservative containing 55% of the active ingredient dimethyloldimethylhydantoin.
DMDM hydantoin is a low-cost, highly effective preservative that offers protection against a broad spectrum of microorganisms, including Gram-positive and Gram-negative bacteria, yeasts, and molds.


DMDM Hydantoin is a clear liquid broad-spectrum preservative system against gram-positive and gram-negative bacteria, yeast, and mold.
DMDM hydantoin is compatible with most cosmetic ingredients, it is non-irritating and non-sensitizing.
DMDM Hydantoin (DiMethyl Dimethyl Hydantoin; CAS: 461-72-3) is an antimicrobial preservative.



USES and APPLICATIONS of DMDM HYDANTOIN:
DMDM hydantoin works by slowing and preventing spoilage in personal care products such as shampoos and hair conditioners, moisturizers and foundation makeup.
As an antimicrobial, DMDM hydantoin can help prevent the growth of fungi, yeast and harmful bacteria.


DMDM hydantoin has been approved for use in cosmetic and personal care products under established safety limits by the Cosmetic Ingredient Review and other scientific panels.
Uses & Benefits of DMDM hydantoin: Cosmetics and Personal Care Products and cosmetics


DMDM hydantoin is a preservative in cosmetics and personal care products.
DMDM hydantoin works by slowing and preventing spoilage in products such as shampoos and hair conditioners, and in skin care products like moisturizers and makeup foundations.


DMDM hydantoin, a white, odorless preservative, commonly appears in shampoos, conditioners, styling products, moisturizers, and even foundation makeup
DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners and skin care products.
DMDM hydantoin is a formaldehyde releaser or donor, meaning it slowly releases the chemical formaldehyde as it breaks down in the product over time to prevent mold and bacteria from growing.


DMDM hydantoin works by slowing or stopping the growth of potentially harmful microbes such as fungi, yeast and bacteria.
DMDM hydantoin is a white, crystalline solid.
In cosmetics and personal care products, DMDM hydantoin is used in the formulation of shampoos, hair conditioners, skin care products, moisturizers, bath products, and makeup bases and foundations.


DMDM hydantoin is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria.
DMDM hydantoin can be found in products like shampoos, hair conditioners, hair gels, and skin care products from the cosmetics industry.
DMDM hydantoin is used a controversial preservative that has formaldehyde-releasing properties.


DMDM hydantoin works great against bacteria and also has mild fungicide abilities.
The amount of formaldehyde used in cosmetics either neat or through formaldehyde-releasing preservatives is tiny.
Probably that is why the Cosmetic Ingredient Review Broad concluded both in 1988 and in 2008 that DMDM Hydantoin is "safe as used in cosmetics".


As a result, DMDM hydantoin increases the shelf-life of cosmetics and personal care products.
Preservatives are essential for such products that contain water, including shampoos, conditioners and body washes
DMDM hydantoin is approved for use as a preservative in personal care products and cleaners.


DMDM hydantoin is widely used in formulations of shampoos, conditioners, rinses, liquid soaps, shower gels, sensitive skin lotions, moisturizers, cold creams, mild shampoos, bubble baths, baby wipes, sunscreen lotions and creams.
Typical use levels of DMDM hydantoin are from 0.20-0.60%.


DMDM hydantoin is widely used in the cosmetics and personal care industry as a sterilising preservative for conditioner, shampoo, and other daily chemical products.
DMDM hydantoin is used in the pharmaceutical, cosmetic and personal care industry, and is also used in herbicides, polymer, colour photography, adhesives, latex paints, cutting oils, floor waxes and inks, among others.


DMDM hydantoin is used as a preservative in cosmetic products at concentrations up to 1% and in industrial applications at up to 2%.
DMDM Hydantoin is used in the cosmetics industry, particularly in hair and water-rich products such as shampoos, conditioners, gels and skin care products.
DMDM Hydantoin slowly releases formaldehyde and acts as a preservative by making the environment less favourable to micro-organisms including fungi, yeasts and bacteria.


DMDM Hydantoin is also found in other consumer products such as herbicides, latex paints, polishes, stripping oils, adhesives and inks.
DMDM hydantoin functions as a preservative by making the environment unfavourable to bacteria as it steadily releases formaldehyde.
DMDM hydantoin is found in cosmetic products such as shampoos, conditioners, hair gels, and skincare products.


DMDM hydantoin is used in a wide variety of formulations due to its preservative efficacy and suitable wide pH range.
DMDM Hydantoin is used as a preservative in cosmetics and acts against fungi, yeasts and bacteria.
DMDM hydantoin is a liberator of formaldehyde (formol).


DMDM hydantoin is also found in many other consumer products such as herbicides, latex paints, polishes, stripping oils, adhesives, photocopy paper or inks.
DMDM Hydantoin (DMDMH) is halogen and paraben free, and is highly effective against Gram-positive and Gram-negative bacteria in both leave-on and rinse-off products such as shampoo, liquid soap, shower gel, conditioner, body lotion, skin creams, sunscreen, eye cream, hair gel and make-up remover.


Due to high water solubility, DMDM hydantoin can be added to aqueous systems without heating, making it easy to use.
DMDM hydantoin is used all kinds of skin & hair care products, wipes, sun care products, & makeup products.
DMDM hydantoin is recommended for use in rinse-off and leave-on personal care applications including facial cleansers, hand cleansers, body cleansers, hair shampoos, hair conditioners, moist towelettes, sun care, and skin care.


Because DMDM hydantoin is a formaldehyde donor, it releases small amounts of formaldehyde over time which works to keep mold and bacteria from forming.
At a concentration of less than 1 percent in cosmetics and personal care products, the amount of formaldehyde released from shampooing one’s hair is less than the amount of formaldehyde that is naturally produced by one medium sized apple or pear.


DMDM hydantoin is poorly absorbed by the skin and is not a skin irritant except in cases of people with severe formaldehyde allergies.
There are no adverse effects from oral exposure.
As one of the best antimicrobial agents on the market, DMDM hydantoin helps to prevent the growth of harmful fungi and bacteria over the useful life of many personal care products.


DMDM hydantoin is a very safe preservative at recommended concentrations and is one of the most frequently used formaldehyde releaser preservatives on the market today.
DMDM hydantoin is used functions as a formaldehyde donor and is used as a preservative in cosmetic products and is active against fungi, yeasts, and bacteria.


Products preserved are of the type shampoos, skin-care products, hair conditioners, makeup, hair rinses, and cleanliness products.
DMDM hydantoin is also used in herbicides, polymers, color photography, latex paints, floor waxes, cutting oils, adhesives, copying paper, inks.
DMDM hydantoin contains 1% sorbitan sesquioleate as emulsifier.


DMDM hydantoin is a substance that works as a preservative in cosmetics and personal care products like shampoos, conditioners, moisturizers, facial cleansers, and makeup.
DMDM hydantoin extends the shelf life of the product.


DMDM hydantoin prevents the product from spoiling and contamination with fungi, yeast and bacteria that can make people sick or give them rashes.
DMDM hydantoin is used in shampoos, conditioners, cosmetics as a bactericidal preservative
DMDM hydantoin is used in cosmetics and personal hygiene products such as moisturizers, hair conditioners, etc.


Because of its effective preservative feature, DMDM hydantoin is famed to be used in skincare products.
DMDM hydantoin acts as an excellent preservative in cosmetics.
DMDM hydantoin is used in wipes, oral care, baby care, rinse-off and leave-on products.


DMDM hydantoin uses in cosmetics Preservatives play an important role in so many products people use in their day-to-day routine; preservatives help prevent the development of harmful microorganisms and keeping the products away from spoilage. Hence DMDM hydantoin is useful for several purposes.
DMDM hydantoin is used in shampoos, skin care products, hair products, makeup, conditioners and make-up removers.


-applying hand cream:
DMDM hydantoin is also an antimicrobial agent used in cosmetics and personal care products.
As an antimicrobial, DMDM hydantoin can help prevent the growth of fungi, yeast and harmful bacteria that can make people sick or give them rashes, for example.



INDUSTRIES OF DMDM HYDANTOIN:
DMDM hydantoin releases antimicrobial formaldehyde, making it one of the most efficient artificial preservatives in the world.
DMDM hydantoin is an organic compound that finds its place in the hydantoins class of compounds.
DMDM hydantoin finds extensive use in the cosmetics industry as an active preservative for products like:

*Skin care composition
*Shampoos
*Hair gels
*Hair conditioners

Being an effective preservative, DMDM Hydantoin is used in the concentrated form of 1%.
As mentioned earlier, DMDM hydantoin is a donor of formaldehyde making it capable of creating a not-so-favourable ambience within the cosmetic product for microorganisms to thrive.



APPLICATIONS AND BENEFITS OF DMDM HYDANTOIN:
DMDM hydantoin is a favourite among mass producers of cosmetics and skin care products all over the globe.
DMDM hydantoin has shown efficiency when it comes to slowing down the spoilage rate of products and improves their shelf life.
DMDM hydantoin is one of the best antimicrobial agents that helps prevent the growth of yeast, fungi and harmful dermatological bacteria that if left unchecked can result in skin rashes, and related illnesses in users.



FORMALDEHYDE IN SHAMPOO, DMDM HYDANTOIN:
Part of the chemical breakdown process for DMDM hydantoin involves a small, consistent release of formaldehyde, a strong-smelling gas.
Industry research has confirmed and reaffirmed the acceptable level of formaldehyde, as long as it does not exceed a certain amount in the product.
For context, the amount of formaldehyde released is equivalent to naturally occurring levels found in a medium-sized pear.
Formaldehyde is commonly used in the production of many building materials and products for your household – including hair products.
DMDM hydantoin is used permanent-press fabrics contain formaldehyde; as do glues, adhesives, and particle board.
You can also find formaldehyde in fingernail polish, shower gel and even lotions.



USES AND BENEFITS OF DMDM HYDANTOIN:
Some products that may contain DMDM hydantoin include:
*shampoos
*conditioners
*makeup
*makeup removers
*liquid hand soaps
*styling products
*facial cleansers
*moisturizers
*sunscreen
DMDM hydantoin has antimicrobial properties, which means it can help kill small organisms and preserve the product’s freshness.

Antimicrobial chemicals such as DMDM hydantoin can help prevent the growth of potentially harmful:
*bacteria
*fungus
*yeast

Cosmetic companies often add DMDM hydantoin to their products to help prevent the growth of these organisms.
This helps protect the user from potential skin infections and makes the product last longer.
Bacteria often grow well in warm, wet environments.
DMDM hydantoin can prevent their growth on personal care products kept in the bathroom, which is prone to warmth and moisture.



WHAT IS DMDM HYDANTOIN USED FOR?
DMDM hydantoin works as an antimicrobial in cosmetic and personal care products.
DMDM hydantoin functions as an antibacterial agent and can aid in limiting the development of harmful bacteria, yeast, and fungi.

DMDM hydantoin is a preservative that slows and prevents spoilage in items like shampoos and hair conditioners as well as in skin care items like moisturizers and foundations.
DMDM hydantoin is a "formaldehyde donor," which means that over the course of a personal care product or cosmetic product's shelf life, it releases minute quantities of formaldehyde to function as a preservative and an antimicrobial.



ORIGIN OF DMDM HYDANTOIN:
DMDM hydantoin is produced by reacting 3 to 5 moles of formaldehyde, as the 37% by weight aqueous solution, with 1 mole of dimethyl hydantoin at 84°C.
A highly concentrated aqueous solution of DMDM hydantoin is prepared by reacting 2 moles of formaldehyde, as 37% formalin, with dimethyl hydantoin at 38 to 50°C, pH 8.1-8.3.



WHAT DOES DMDM HYDANTOIN DO IN A FORMULATION?
*Antimicrobial
*Preservative



USAGE AND BENEFITS OF DMDM HYDANTOIN:
DMDM hydantoin is used as a preservative in cosmetics.
The preservative, just like food in cosmetics, also serves the purpose of protecting it throughout its shelf life.
Without it, DMDM hydantoin may change color, develop brown/black spots, or split into two distinct stages.

They act by reducing bacterial growth in a product.
Acting against exposure to oxygen is the second aspect of preservatives, they act as antioxidants and prevent oxidation of a product.
Thus, DMDM hydantoin protects the product ingredients from oxidizing or changing its chemical structure with light, heat or moisture and disrupts the balance of the product.

DMDM hydantoin is also considered an antimicrobial agent.
DMDM hydantoin is a broad-spectrum agent that is effective against many bacteria, fungi, yeast and mold.
As mentioned before, DMDM hydantoin ​​releases, formaldehyde, in too small a concentration to exert its effect as an antimicrobial agent.
DMDM hydantoin is used in the formulation of shampoos and conditioners, moisturizers, skin care products, make-up wipes and foundations.



WHERE DMDM HYDANTOIN FOUND?
DMDM hydantoin is used as a preservative in cosmetics, skin care products, and other personal hygiene products.
DMDM hydantoin may release formaldehyde and crossreactions to other formaldehyde-releasing substances may occur.



WHAT ARE SOME PRODUCTS THAT MAY CONTAIN DMDM HYDANTOIN?
*Baby and General Care Wipes
*Body Washes
*Cosmetics
*Diaper Cream
*Hair Colorants
*Hair Styling Products
*Hand Soaps
*Pet Care Products
*Polishes
*Shampoo/Conditioners
*Shaving Cream, Gel
*Skin Care and Lotions
*Soaps/Cleanser



FUNCTIONS OF DMDM HYDANTOIN IN COSMETIC PRODUCTS:
*PRESERVATIVE:
DMDM hydantoin protects cosmetic products from microbial spoilage



ORIGIN OF DMDM HYDANTOIN:
DMDM hydantoin is a synthetic



BACKGROUND INFORMATION OF DMDM HYDANTOIN ON USE IN COSMETICS:
DMDM hydantoin is a so-called formaldehyde releaser.
Preservatives protect cosmetic products against microbial spoilage and hence make a major contribution to consumer health.

Preservatives are particularly required in cosmetic formulations containing water, because microorganisms can colonise and reproduce in an aqueous (water-containing) environment.
Cosmetics often contain more than one preservative substances and these preservative systems act simultaneously against different bacteria, yeasts or moulds.

Each of these substances has been comprehensively tested and assessed for safety (individually and in combination).
Manufacturers always use only the lowest possible effective concentration in a product so that an optimum shelf life and safe application are ensured.
Formaldehyde releasers continuously release a low amount of formaldehyde in the finished cosmetic product and deploy their preservative effect in this way.
DMDM hydantoin is a chemical used in a wide range of cosmetic products.



WHAT IS A FORMALDEHYDE-RELEASER?
DMDM hydantoin is a type of formaldehyde-releaser.
A formaldehyde-releaser is a chemical often found in personal care products. It releases small amounts of formaldehyde over time to preserve the products.
A person’s skin can absorb the chemical while using the product.



ALTERNATIVES OF DMDM HYDANTOIN:
*QUATERNIUM15,
*SODIUM BENZOATE



TYPE OF INGREDIENT:
Preservative


MAIN BENEFITS OF DMDM HYDANTOIN::
DMDM hydantoin helps to prevent the growth of bacteria in shampoos, conditioners, and some cosmetics


WHO SHOULD USE DMDM HYDANTOIN:
Those who are comfortable using products that contain the ingredient, or haven’t had a negative reaction to DMDM hydantoin


DMDM HYDANTOIN WORKS WELL WITH:
DMDM hydantoin formulas prone to bacteria growth


DMDM HYDANTOIN DON’T USE WITH:
Notes that DMDM hydantoin shouldn’t be paired with other formaldehyde donors like quaternium-15.


STRENGHTS OF DMDM HYDANTOIN:
DMDM hydantoin has excellent antimicrobial properties



BENEFITS OF DMDM HYDANTOIN:
• DMDM hydantoin acts as a preservative
• DMDM hydantoin retards microbial growth
• DMDM hydantoin is used in a wide variety of products



BENEFITS OF DMDM HYDANTOIN:
*Effective broad-spectrum preservation against gram-positive and gram-negative bacteria, yeast, and mold
*For its high water solubility, it is particularly suggested for aqueous formulations and emulsions
*Extends shelf life of personal care products typically to 6-18 months
*DMDM hydantoin is compatible with most cosmetic ingredients
*Product is non-irritating and non-sensitizing
*Environmentally friendly as DMDM hydantoin will not build up in aquatic organisms and will be broken down by microorganisms in soil.



SPECIFICATION OF DMDM HYDANTOIN:
DMDM hydantoin for skin is used in personal care and cosmetic products; what is the primary function of DMDM hydantoin in skincare products?
First, DMDM hydantoin slows down product spoilage (such as hair conditioners, skincare products like moisturizers and foundations).



IS DMDM HYDANTOIN SAFE:
Yes, DMDM hydantoin is safe in cosmetic ingredient (if used in appropriate concentration); it is non-toxic as a preservative constituent used in cosmetics, and skincare products, general care wipes, hair styling products, hand soaps, shaving creams, skincare, lotions, and hair colorants.



BENEFITS AND APPLICATIONS OF DMDM HYDANTOIN:
DMDM hydantoin is used as an antibacterial ingredient in cosmetics and personal care products.
Product compositions containing DMDM Hydantoin can be used many times per day.
DMDM hydantoin works well with a variety of skincare, haircare, and sun protection products.

As an additional bonus, DMDM hydantoin also provides mositurising and conditioning characteristics to various products.
DMDM hydantoin also treats dermatological conditions such as acne, burns, and lacerations.
DMDM hydantoin is used as an aqueous spray, mouthwash, and to treat eye and ear infections.



HOW DMDM HYDANTOIN WORKS:
DMDM hydantoin works by inhibiting the formation of fungus, yeast, and harmful bacteria that can cause skin infection or cause rashes as an antibacterial.
DMDM hydantoin works by slowing and preventing spoilage in shampoos and conditioners, as well as in skin care products such as moisturisers and cosmetic foundations.



CONCENTRATION AND SOLUBILITY OF DMDM HYDANTOIN:
DMDM hydantoin is recommended that it should be used at a maximum concentration of 0.6% for cosmetic and personal care products.
DMDM hydantoin is highly soluble in water and alcohol but insoluble in volatile oils.



HOW TO USE DMDM HYDANTOIN:
Get your formulation ready.
Add our DMDM hydantoin during the cooling phase.
Stir DMDM hydantoin to mix well with other ingredients.



WHERE IS DMDM HYDANTOIN FOUND?
DMDM hydantoin is used as a preservative in cosmetics, skin care products, and other personal hygiene products.
DMDM hydantoin may release formaldehyde and cross- reactions to other formaldehyde-releasing substances may occur.



FUNCTION OF DMDM HYDANTOIN:
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.
DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, Rite Aid Liquid Lubricant, and skin care products.
DMDM hydantoin works as a preservative because the released formaldehyde makes the environment less favorable to the microorganisms.



YOU CAN FIND DMDM HYDANTOIN IN:
*Makeups
*Makeup removers
*Shampoos
*Conditioners
*Hair styling products
*Moisturizers
*Liquid hand soaps
*Facial cleansers
*Exfoliants or scrubs


Formaldehyde-releasing preservatives like DMDM hydantoin help keep beauty products from spoiling.
While formaldehyde-releasing ingredients can be dangerous in high levels, these chemicals are found naturally in safe, small amounts in many foods.

They include:
*Bananas
*Apples
*Plums
*Grapes
*Onions
*Carrots
*Spinach
*Seafood
*Beef
*Poultry
Our bodies, and those of most other living organisms, also make small amounts of formaldehyde as part of the normal process of metabolism.



BENEFITS OF DMDM HYDANTOIN:
DMDM hydantoin helps your personal-care items stay fresh for long periods.
DMDM hydantoin stops or slows down the growth of potentially harmful fungi, yeast, and bacteria.



WHERE TO FIND DMDM HYDANTOIN?
Make-up remover, shampoos, conditioners, hair gels/lotions, intimate toilets, face masks, face creams, shower gels, shaving foams, foundations, liquid hand soaps, scrubs, concealers, hand creams, after-sun care, self-tanners, hair mists, foot creams, facial cleansers, serums, primers.



FUNCTION OF DMDM HYDANTOIN:
*Preservative.



WHY IS DMDM HYDANTOIN USED?
DMDM hydantoin is a formaldehyde-donor preservative
Ingredients that prevent or retard bacterial growth, and thus protect cosmetic products from spoilage.
DMDM hydantoin prevents or retards microbial growth, thereby protecting cosmetics and personal care products from spoilage.



SCIENTIFIC FACTS OF DMDM HYDANTOIN:
DMDM hydantoin is a broad-spectrum antimicrobial agent
Ingredients that kill microorganisms, or prevent or inhibit their growth and reproduction.
In the United States, antimicrobial agents are regulated as Over-The-Counter (OTC) drug ingredients.
DMDM hydantoin is effective against fungi, yeast, and bacteria.



PHYSICAL and CHEMICAL PROPERTIES of DMDM HYDANTOIN:
Chemical formula: C7H12N2O4
Molar mass: 188.18 g/mol
Physical state: liquid
Color: No data available
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available

Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available
Molecular Formula: C7H12N2O4
Molecular Weight: 188.181
Density: 1.4±0.1 g/cm3
Boiling point: 303.7±52.0 °C at 760 mmHg
Flash point: 137.5±30.7 °C
Index of Refraction: 1.529

Appearance: Whtie crystalline powder
Assay:≥95.0%
Moisture(K.F):≤1.0%
Total formaldehyde: ≥29.0%
Free formaldehyde: ≤0.1%
Molecular Weight: 188.18 g/mol
XLogP3-AA: -0.2
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 188.07970687 g/mol
Monoisotopic Mass: 188.07970687 g/mol
Topological Polar Surface Area: 81.1Ų
Heavy Atom Count: 13
Formal Charge: 0
Complexity:251

Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Boiling Point: 198-200°C
Melting Point: 90°C
Solubility: Soluble in water and ethanol
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 303.71 °C. @ 760.00 mm Hg (est)
Flash Point: 279.00 °F. TCC ( 137.50 °C. ) (est)
logP (o/w): -1.078 (est)
Soluble in: water, 2.612e+005 mg/L @ 25 °C (est)



FIRST AID MEASURES of DMDM HYDANTOIN:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DMDM HYDANTOIN:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of DMDM HYDANTOIN:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of DMDM HYDANTOIN:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Face shield and safety glasses
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Complete suit protecting against chemicals.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DMDM HYDANTOIN:
-Precautions for safe handling:
*Hygiene measures:
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store at Room Temperature.



STABILITY and REACTIVITY of DMDM HYDANTOIN:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

DESCRIPTION:
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.
DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, and skin care products.
DMDM hydantoin slowly releases formaldehyde and works as a preservative by making the environment less favorable to microorganisms.


CAS Number, 6440-58-0
EC Number, 229-222-8

DMDM hydantoin is a preservative and antimicrobial agent found in a wide range of cosmetics and skin-care and hair-care products.
DMDM hydantoin is considered a “formaldehyde donor.”
That means DMDM hydantoin releases a small amount of formaldehyde over time to help keep products fresh and free from contaminants.


DMDM hydantoin is found in:
• Makeups
• Makeup removers
• Shampoos
• Conditioners
• Hair styling products
• Moisturizers
• Liquid hand soaps
• Facial cleansers
• Exfoliants or scrubs



Formaldehyde-releasing preservatives like DMDM hydantoin help keep beauty products from spoiling.
While formaldehyde-releasing ingredients can be dangerous in high levels, these chemicals are found naturally in safe, small amounts in many foods.


They include:
• Bananas
• Apples
• Plums
• Grapes
• Onions
• Carrots
• Spinach
• Seafood
• Beef
• Poultry
Our bodies, and those of most other living organisms, also make small amounts of formaldehyde as part of the normal process of metabolism.


DMDM hydantoin is an antimicrobial formaldehyde releaser preservative.
People exposed to such formaldehyde-releasing ingredients may develop a formaldehyde allergy or an allergy to the ingredient itself and its decomposition products.

In the U.S., approximately 20% of cosmetics and personal care products contain a formaldehyde-releaser and the frequency of contact allergy to these ingredients is much higher among Americans compared to studies in Europe.

DMDM hydantoin is an odorless white, crystalline substance that works as an antimicrobial agent and preservative in cosmetics and personal care products.

DMDM hydantoin works by slowing and preventing spoilage in personal care products such as shampoos and hair conditioners, moisturizers and foundation makeup.
As an antimicrobial, DMDM hydantoin can help prevent the growth of fungi, yeast and harmful bacteria.
DMDM hydantoin is a “formaldehyde donor,” which means that to work as a preservative and antimicrobial, it releases small levels of formaldehyde throughout the shelf-life of a personal care product or cosmetic products.

DMDM (dimethyl-dimethyl) hydantoin is an organic compound that is a member of the hydantoin family.
DMDM hydantoin functions as an antimicrobial preservative by discharging formaldehyde.
DMDM hydantoin is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria.

DMDM hydantoin can be found in products like shampoos, hair conditioners, hair gels, and skin care products from the cosmetics industry.



DMDM Hydantoin is an excellent preservative for both leave-on and rinse-off products such as shampoos, creams, lotions, bubble baths, rinses, wipes and towelettes.
DMDM Hydantoin is easy to handle, very stable and cost-effective.

1,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin) is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM hydantoin is an organic compound belonging a class of compounds known as hydantoins.
DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners and skin care products.




USES & BENEFITS OF DMDM HYDANTOIN:
Cosmetics and Personal Care Products
DMDM hydantoin is a preservative in cosmetics and personal care products.
DMDM hydantoin works by slowing and preventing spoilage in products such as shampoos and hair conditioners, and in skin care products like moisturizers and makeup foundations.

DMDM hydantoin is also an antimicrobial agent used in cosmetics and personal care products.
As an antimicrobial, DMDM hydantoin can help prevent the growth of fungi, yeast and harmful bacteria that can make people sick or give them rashes, for example.




SAFETY:
A patch test study found that "an increase in the use of DMDM hydantoin in cosmetic products will also inevitably increase the risk of cosmetic dermatitis in consumers allergic to formaldehyde."
The safety of formaldehyde is a topic of ongoing concern, given the prevalence of formaldehyde and formaldehyde releasers in industrial uses.
Formaldehyde is considered "an important metabolic product in plants and animals (including humans), where it occurs in low but measurable concentrations.


However, long-term exposure to formaldehyde (particularly routine inhalation of its fumes) is thought to cause irritation of the eyes and mucous membranes, headaches, shortness of breath, and aggravation of asthma symptoms.
It was declared a "toxic product" by the 1999 Canadian Environmental Protection Act, and the US National Toxicology Program officially classed formaldehyde as "known to be a human carcinogen in June 2011.
In the EU, the maximum allowed concentration of formaldehyde in finished products is 0.2%, and any product that exceeds 0.05% has to include a warning that the product contains formaldehyde.


BENEFITS OF DMDM HYDANTOIN
DMDM hydantoin helps your personal-care items stay fresh for long periods.
The chemical stops or slows down the growth of potentially harmful fungi, yeast, and bacteria.


CHEMICAL AND PHYSICAL PROPERTIES OF DMDM HYDANTOIN:
Chemical formula, C7H12N2O4
Molar mass, 188.18 g/mol
CAS Number, 6440-58-0
Chem/IUPAC Name:, 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
EINECS/ELINCS No:, 229-222-8
Molecular Weight
188.18 g/mol
XLogP3-AA
-0.2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
2
Exact Mass
188.07970687 g/mol
Monoisotopic Mass
188.07970687 g/mol
Topological Polar Surface Area
81.1Ų
Heavy Atom Count
13
Formal Charge
0
Complexity
251
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes



SYNONYMS OF DMDM HYDANTOIN:
6440-58-0
1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
DMDM Hydantoin
Dimethyloldimethyl hydantoin
Glydant
Dmdmh
1,3-Bis(hydroxymethyl)-5,5-dimethylhydantoin
1,3-Dimethylol-5,5-dimethylhydantoin
Dantoin-DMDMH
Glycoserve-DMDMH
Dantoin dmdmh 55
Dimethylol-5,5-dimethylhydantoin
Dmdmh 55
Caswell No. 273AB
dimethyloldimethylhydantoin
UNII-BYR0546TOW
2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
EINECS 229-222-8
BYR0546TOW
EPA Pesticide Chemical Code 115501
1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione
BRN 0882348
DTXSID8035217
HSDB 7488
1,3-Di(hydroxymethyl)-5,5-dimethylhydantoin
DTXCID6015217
1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN
EC 229-222-8
1,3-DIHYDROXYMETHYL-5,5-DIMETHYLHYDANTOIN
Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
MFCD00467199
DMDM HYDANTOIN (II)
DMDM HYDANTOIN [II]
Dantoguard
Dantion DMDMH 55
DMDM HYDANTION
1,3-Dihydroxylmethyl-5,5-dimethylhydantoin
SCHEMBL69185
DMDM HYDANTOIN [INCI]
DMDM HYDANTION [VANDF]
DMDM HYDANTOIN [VANDF]
DDAC0.6%
DDAC0.15%
WSDISUOETYTPRL-UHFFFAOYSA-N
Tox21_303842
AKOS006345746
n,n'-dimethylol-5,5-dimethylhydantoin
CS-W021276
USEPA/OPP Pesticide Code: 115501
NCGC00356947-01
AS-10924
SY101650
CAS-6440-58-0
FT-0606699
H11751
A834743
Q5205613
W-104844
1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB]
1,3-Bis (hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
1,3 BIS(HYDROXYMETHYL)-5,5- DIMETHYLHYDANTOINDIMETHYLHYDANTOIN
1,3 BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOINDIMETHYLHYDANTOIN
5-ethyl-1,3-dihydroxy-5-methyl-imidazolidine-2,4-dione;1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione

DMDM hydantoin has come under fire in recent years, mainly because it releases small amounts of formaldehyde.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative.
DMDM hydantoin slowly releases formaldehyde and works as a preservative by making the environment less favorable to microorganisms.

CAS Number: 6440-58-0
Molecular Formula: C7H12N2O4
Molecular Weight: 188.18
EINECS Number: 229-222-8

Synonyms: 6440-58-0, 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, DMDM Hydantoin, Dimethyloldimethyl hydantoin, Glydant, Dmdmh, 1,3-Bis(hydroxymethyl)-5,5-dimethylhydantoin, 1,3-Dimethylol-5,5-dimethylhydantoin, Dantoin-DMDMH, Glycoserve-DMDMH, Dantoin dmdmh 55, Dimethylol-5,5-dimethylhydantoin, Dmdmh 55, Caswell No. 273AB, 2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-, dimethyloldimethylhydantoin, UNII-BYR0546TOW, EINECS 229-222-8, BYR0546TOW, EPA Pesticide Chemical Code 115501, 1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, BRN 0882348, DTXSID8035217, HSDB 7488, 1,3-Di(hydroxymethyl)-5,5-dimethylhydantoin, DTXCID6015217, 1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN, EC 229-222-8, Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-, MFCD00467199, DMDM HYDANTOIN (II), DMDM HYDANTOIN [II], Dantoguard, 1,3-DIHYDROXYMETHYL-5,5-DIMETHYLHYDANTOIN, Dantion DMDMH 55, DMDM HYDANTION, 1,3-Dihydroxylmethyl-5,5-dimethylhydantoin, SCHEMBL69185, DMDM HYDANTION [VANDF], DMDM HYDANTOIN [VANDF], DDAC0.6%, DDAC0.15%, Tox21_303842, AKOS006345746, n,n'-dimethylol-5,5-dimethylhydantoin, CS-W021276, USEPA/OPP Pesticide Code: 115501, NCGC00356947-01, AS-10924, SY101650, CAS-6440-58-0, NS00007210, H11751, A834743, Q5205613, W-104844, 1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB], 1,3-Bis (hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, 1,3 BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOINDIMETHYLHYDANTOIN, 1,3 BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOINDIMETHYLHYDANTOIN, 1 pound not3-Bis(hydroxymethyl)-5 pound not5-dimethylimidazolidine-2 pound not4-dione, 5-ethyl-1,3-dihydroxy-5-methyl-imidazolidine-2,4-dione, 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione

DMDM hydantoin helps prevent your products from going bad, but at high doses, it may have the potential to cause cancer in humans Trusted Source.
Many people have started to pay closer attention to the ingredients in their skin and hair care products, thanks, in part, to the clean beauty movement.

One particular ingredient, DMDM hydantoin, has attracted plenty of negative attention.
DMDM hydantoin, a white, odorless preservative, commonly appears in shampoos, conditioners, styling products, moisturizers, and even foundation makeup, says Enrizza Factor, MD, a board certified dermatologist and owner of EPF Dermatology Skin Therapy.

DMDM Hydantoin is an excellent preservative for both leave-on and rinse-off products such as shampoos, creams, lotions, bubble baths, rinses, wipes and towelettes.
DMDM hydantoin is easy to handle, very stable and cost-effective.
The main benefits of DMDM hydantoin lie in its antimicrobial properties.

In basic terms, this means DMDM hydantoin can help prevent the growth of mold and other fungi, yeast, and harmful bacteria, Factor says. As a result, products that contain this ingredient might remain fresher (and safer to use) for longer periods of time.
Preservatives like DMDM hydantoin play an especially important role in products you keep in your shower — think shampoo, conditioner, and body wash — since the warm, humid conditions can encourage bacteria to grow.

DMDM hydantoin works by slowing and preventing spoilage in personal care products such as shampoos and hair conditioners, moisturizers and foundation makeup.
This ingredient is a formaldehyde donor containing up to 2% of the free aldehyde in equilibrium with the hydantoin.
Preserves and aids in the control of bacteria and fungi in liquid detergents, fabric softeners, household cleaning products, soft soaps, water-based paints for household and industrial use, room deodorizers and air fresheners, water-based surfactants, polymer emulsions, protective or decorative coatings, water-based gels for household and industrial products, textiles, water-based adhesives, sealants and caulks, latex for paper coatings, and water-based inks.

DMDM hydantoin is a formaldehyde releaser or donor, meaning it slowly releases the chemical formaldehyde as it breaks down in the product over time to prevent mold and bacteria from growing.
It works by slowing or stopping the growth of potentially harmful microbes such as fungi, yeast and bacteria.
As a result, DMDM hydantoin increases the shelf-life of cosmetics and personal care products.

Preservatives are essential for such products that contain water, including shampoos, conditioners and body washes.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.

DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, and skin care products.
DMDM hydantoin slowly releases formaldehyde and works as a preservative by making the environment less favorable to microorganisms.
A patch test study found that "an increase in the use of DMDM hydantoin in cosmetic products will also inevitably increase the risk of cosmetic dermatitis in consumers allergic to formaldehyde."

The safety of formaldehyde is a topic of ongoing concern, given the prevalence of formaldehyde and formaldehyde releasers in industrial uses.
Formaldehyde is considered "an important metabolic product in plants and animals (including humans), where it occurs in low but measurable concentrations."
However, long-term exposure to formaldehyde (particularly routine inhalation of its fumes) is thought to cause irritation of the eyes and mucous membranes,headaches, shortness of breath, and aggravation of asthma symptoms.

DMDM hydantoin was declared a "toxic product" by the 1999 Canadian Environmental Protection Act, and the US National Toxicology Program officially classed formaldehyde as "known to be a human carcinogen in June 2011.
In the EU, the maximum allowed concentration of formaldehyde in finished products is 0.2%, and any product that exceeds 0.05% has to include a warning that the product contains formaldehyde.
Used as a biocide in cosmetics with 0.6% the maximum allowable concentration in the EU; Used as an antimicrobial pesticide in cleaning products, adhesives, air fresheners, caulks, hydraulic fluids, inks, metal working cutting fluids, paints, stains, coatings, paper and paperboard coatings, polishes, synthetic polymers, sealants, starch solutions, resin emulsions, textiles, and wax.

DMDM hydantoin protect cosmetic products against microbial spoilage and hence make a major contribution to consumer health.
DMDM hydantoin are particularly required in cosmetic formulations containing water, because microorganisms can colonise and reproduce in an aqueous (water-containing) environment.
Cosmetics often contain more than one preservative substances and these preservative systems act simultaneously against different bacteria, yeasts or moulds.

Each of these substances has been comprehensively tested and assessed for safety (individually and in combination).
Manufacturers always use only the lowest possible effective concentration in a product so that an optimum shelf life and safe application are ensured.
Formaldehyde releasers continuously release a low amount of formaldehyde in the finished cosmetic product and deploy their preservative effect in this way.

A controversial preservative that has formaldehyde-releasing properties.
DMDM hydantoin works great against bacteria and also has mild fungicide abilities.
Cosmetic chemist, Colin wrote a great article about formaldehyde and DMDM Hydantoin.

DMDM hydantoin's a natural stuff that can also be found in fresh fruits and vegetables, and eating it in tiny amounts is totally ok.
However, in larger amounts (according to Wikipedia 30 mL of a solution containing 37% formaldehyde) it's deadly.
DMDM hydantoin, a preservative that is highly soluble in water and adaptable enough for a wide range of personal care products.

DMDM hydantoin- spectrum activity against Gram- negative and Gram- positive bacteria, yeast and mould; effective over the range pH 3.0 – 8.0; Retains activity in presence of nonionic surfactants and most other common ingredients; Highly soluble in water and readily incorporated into products, ideal preservative for bulk surfactants.
Recommended use level is 0.15-0.4 %. remains fully stable over a wide pH range from 3.0-8.0. should be incorporated during the cooling stage of hot processes.
DMDM hydantoin, is a common preservative ingredient found in cosmetics production, construction materials, and household products.

The chemical compound is typically added to products in minute quantities as an antimicrobial agent.
Certain consumer advocates fear that when combined with other chemicals, the substance may cause cancer.
Some individuals may develop skin irritations while using topical products containing this chemical formulation.

Other names for the compound include 1,2-demithylol-5,5 dimethyl hydantoin and dimethyl-2,4-imidazolidinedione.
DMDM hydantoin is generally an organic compound that prevents bacterial, fungal, and viral development.
By regulation standards, products usually contain only 0.1% to 0.6% of the substance.

Different physical forms of the compound include a colorless liquid, a crystalline powder, or white to grey colored flakes.
DMDM hydantoin consists of dimethyl hydantoin and formaldehyde.
Common cosmetic products containing DMDM hydantoin include hair conditioners, gels, and shampoos.

Manufacturers also frequently use the substance in cream and lotion-type skin care products.
Many industries incorporate DMDM hydantoin for its fungal and mold resistant properties.
DMDM hydantoin might accompany ingredients used for adhesives, inks, and latex paints.

Herbicides, paper, and photography supplies commonly contain this ingredient.
In addition to DMDM hydantoin, some cosmetic compounds may contain dimethicone, methylparaben, and formaldehyde.
DMDM hydantoin is an oily emollient used for skin softening. Methylparaben and formaldehyde are also antimicrobial preservatives.

Formaldehyde, or CH2O, is a known carcinogen. Other names for the chemical are formalin, methyl aldehyde, morbicid acid, and oxymethylene.
This invention is for the use of DMDM Hydantoin as a pharmaceutical compound for the treatment of malconditions of mammalian and human skin and membranes.
In particular, DMDM Hydantoin may be used to treat dermatological conditions such as acne, burns, and lacerations.

DMDM Hydantoin may also be used as an aqueous spray, mouthwash and may be used to treat eye and ear infections as well as to treat mastitis in cattle.
DMDM Hydantoin is used in a wide range of products to prevent the growth of bacteria, yeast, and mold, thereby increasing the shelf life and safety of these products.
Shampoos and Conditioners: Keeps these hair care products free from microbial contamination.

DMDM hydantoin Ensures skin care products remain stable and safe to use.
DMDM hydantoin İS Used in foundations, powders, and other makeup products to prevent spoilage.
Helps maintain the integrity and safety of these products.

DMDM hydantoin is used in various industrial applications due to its antimicrobial properties:
Prevents microbial growth in these products.
DMDM hydantoin İS Used as a preservative in chemical formulations.

Occasionally used in topical formulations to maintain sterility.
Found in cleaning products to prevent microbial growth.
DMDM Hydantoin works by releasing small amounts of formaldehyde over time.

The formaldehyde acts as a biocide, killing or inhibiting the growth of microorganisms.
This slow release ensures long-lasting antimicrobial protection.
One of the main concerns with DMDM Hydantoin is its release of formaldehyde, a known allergen and potential carcinogen.

However, the amounts released are typically very small and regulated to be within safe limits for use in consumer products.
Some individuals may experience skin irritation or allergic reactions to products containing DMDM Hydantoin, especially those with sensitive skin.
Recognized as a safe ingredient when used within specified limits in cosmetics and personal care products.

Permitted for use in cosmetics but with strict concentration limits to ensure consumer safety.
Generally aligned with FDA and EU guidelines, with specific regulations depending on the country.
DMDM Hydantoin, like other preservatives, can enter the environment through wastewater.

Potential toxicity to aquatic life if present in significant concentrations.
Research is ongoing to understand how it breaks down in the environment and its long-term effects.
Due to concerns about formaldehyde release, some manufacturers are seeking alternatives to DMDM Hydantoin.

DMDM hydantoin an effective preservative with broad-spectrum antimicrobial activity.
Commonly used in food and cosmetics.
DMDM hydantoin is used in food and personal care products.

As an antimicrobial, DMDM hydantoin can help prevent the growth of fungi, yeast and harmful bacteria.
DMDM hydantoin is a “formaldehyde donor,” which means that to work as a preservative and antimicrobial, it releases small levels of formaldehyde throughout the shelf-life of a personal care product or cosmetic products.

DMDM hydantoin has been approved for use in cosmetic and personal care products under established safety limits by the Cosmetic Ingredient Review and other scientific panels.
DMDM Hydantoin is a clear liquid broad-spectrum preservative system against gram-positive and gram-negative bacteria, yeast, and mold.
DMDM hydantoin is used in a wide variety of formulations due to its preservative efficacy and suitable wide pH range.

DMDM hydantoin, a preservative in shampoos, conditioners and other water-based personal care products, is the focus of several class-action lawsuits against Johnson & Johnson and Unilever claiming exposure to the substance led to hair loss.
While there are no studies that link exposure to DMDM hydantoin to hair loss, the preservative is linked to a higher risk for allergic reactions and immunotoxicity.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative.

People exposed to such formaldehyde-releasing ingredients may develop a formaldehyde allergy or an allergy to the ingredient itself and its decomposition products.
In the U.S., approximately 20% of cosmetics and personal care products contain a formaldehyde-releaser and the frequency of contact allergy to these ingredients is much higher among Americans compared to studies in Europe.
DMDM hydantoin is an organic compound that is a member of the hydantoin family.

DMDM hydantoin functions as an antimicrobial preservative by discharging formaldehyde.
DMDM hydantoin is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria.
DMDM hydantoin can be found in products like shampoos, hair conditioners, hair gels, and skin care products from the cosmetics industry.

DMDM hydantoin works as an antimicrobial in cosmetic and personal care products.
It functions as an antibacterial agent and can aid in limiting the development of harmful bacteria, yeast, and fungi.
It is a preservative that slows and prevents spoilage in items like shampoos and hair conditioners as well as in skin care items like moisturizers and foundations.

DMDM hydantoin is a "formaldehyde donor," which means that over the course of a personal care product or cosmetic product's shelf life, it releases minute quantities of formaldehyde to function as a preservative and an antimicrobial.
DMDM hydantoin is produced by reacting 3 to 5 moles of formaldehyde, as the 37% by weight aqueous solution, with 1 mole of dimethyl hydantoin at 84°C.
A highly concentrated aqueous solution of the compound is prepared by reacting 2 moles of formaldehyde, as 37% formalin, with dimethyl hydantoin at 38 to 50°C, pH 8.1-8.3.

DMDM Hydantoin is a cosmetic preservative.
DMDM Hydantoin is described as being a broad-spectrum antimicrobial agent, effective against fungi, yeast, and gram-positive and gram-negative bacteria.
DMDM Hydantoin is a preservative which is used in cosmetic products at concentrations up to 1%.

This preservative does help prevent products from spoiling.
But DMDM hydantoin’s also a common allergen that’s raised concerns in recent years.

DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.
DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, and skin care products.

DMDM hydantoin is a common antimicrobial preservative used in cosmetics, personal care products, and some industrial applications to prevent the growth of microorganisms and extend the shelf life of products.
DMDM hydantoin is a preservative and antimicrobial agent found in a wide range of cosmetics and skin-care and hair-care products.
DMDM hydantoin's considered a “formaldehyde donor.” That means it releases a small amount of formaldehyde over time to help keep products fresh and free from contaminants.

Melting point: 1.00-2.5 °C
Boiling point: 303.7±52.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Sparingly), Methanol (Sparingly)
form: Solid
pka: 13.41±0.10(Predicted)
color: White to Off-White
Water Solubility: 140g/L at 20℃
Stability: Unstable in DMSO solution
LogP: -2.9 at 20℃

DMDM Hydantoin is formaldehyde-donor preservative , that prevents or retards microbial growth, thereby protecting cosmetics and personal care products; body wash and sprays, moisturisers, creams, toners, lotions, cleansers, hair care, pet care.
Formaldehyde is a naturally occurring substance made of carbon, hydrogen and oxygen.
DMDM hydantoin is a substance that works as a preservative in cosmetics and personal care products like shampoos, conditioners, moisturizers, facial cleansers, and makeup.

DMDM hydantoin extends the shelf life of the product.
Antimicrobial preservatives in cosmetics and personal care products help prevent the growth of molds, yeasts and bacteria, guarding against contamination that can cause irritation or infections.
Antioxidant preservatives also can help keep personal care products from spoiling by suppressing reactions that can occur when certain ingredients in a cosmetic or personal care product combine with oxygen in the presence of light, heat and some metals.

DMDM hydantoin is safe as a cosmetic ingredient at current normal levels of use in products, says Factor.
A 2013 safety DMDM hydantoin Source concluded that formaldehyde may be used safely in cosmetics “if established limits are not exceeded.”
According to the Cosmetic Ingredient Review, an independent panel of expert physicians and toxicologists, DMDM hydantoin is safe at levels of 0.074 percent or less.

Cosmetic products typically won’t exceed that limit, according to older research from 1988.
As recently as 2015, the United States and the European Union allow cosmetic and household products to DMDM hydantoin Source up to 0.2 percent of free formaldehyde and up to 0.6 percent of formaldehyde releasers like DMDM hydantoin.
Experts emphasize, though, that even this low concentration could still prompt a skin reaction in people allergic to formaldehyde.

DMDM Hydantoin is a white, crystalline solid. In cosmetics and personal care products, DMDM Hydantoin is used in the formulation of shampoos, hair conditioners, skin care products, moisturizers, bath products, and makeup bases and foundations.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative.

People exposed to such formaldehyde-releasing ingredients may develop a formaldehyde allergy or an allergy to the ingredient itself and its decomposition products.
In the U.S., approximately 20% of cosmetics and personal care products contain a formaldehyde-releaser and the frequency of contact allergy to these ingredients is much higher among Americans compared to studies in Europe.
DMDM hydantoin is a crystal-like, odorless chemical often used in cosmetics as a preservative.

Several products contain the chemical, from makeup and moisturizers to shampoos and conditioners.
DMDM hydantoin is a type of formaldehyde-releaser.
A formaldehyde-releaser is a chemical often found in personal care products.

DMDM hydantoin releases small amounts of formaldehyde over time to preserve the products.
DMDM Hydantoin is a formaldehyde donor and is used as a preservative in cosmetic products shampoos, skin-care products, hair conditioners, makeup and hair rinses.

DMDM Hydantoin is also used in herbicides, polymers, color photography, latex paints, floor waxes, cutting oils, adhesives, copying paper and inks.
Further research may identify additional product or industrial usages of this chemical.
DMDM Hydantoin releases antimicrobial formaldehyde, making it one of the most efficient artificial preservatives in the world.

DMDM hydantoin is an organic compound that finds its place in the hydantoins class of compounds.
DMDM hydantoin finds extensive use in the cosmetics industry as an active preservative for products like:
Being an effective preservative, DMDM Hydantoin is used in the concentrated form of 1%.

As mentioned earlier, DMDM Hydantoin is a donor of formaldehyde making it capable of creating a not-so-favourable ambience within the cosmetic product for microorganisms to thrive.
DMDM hydantoin is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
DMDM hydantoin is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing

DMDM hydantoin prevents the product from spoiling and contamination with fungi, yeast and bacteria that can make people sick or give them rashes.
Part of the chemical breakdown process for DMDM hydantoin involves a small, consistent release of formaldehyde, a strong-smelling gas.
Industry research has confirmed and reaffirmed the acceptable level of formaldehyde, as long as it does not exceed a certain amount in the product.

For context, the amount of formaldehyde released is equivalent to naturally occurring levels found in a medium-sized pear.
Humans produce about 1.5 ounces of formaldehyde a day as a normal part of our metabolism.

Uses:
DMDM hydantoin is a preservative and antimicrobial agent found in a wide range of cosmetics and skin-care and hair-care products.
DMDM hydantoin's considered a “formaldehyde donor.” That means it releases a small amount of formaldehyde over time to help keep products fresh and free from contaminants.
DMDM hydantoin is used in the following products: cosmetics and personal care products, perfumes and fragrances, pharmaceuticals and washing & cleaning products.

DMDM hydantoin is used in the following areas: health services.
Other release to the environment of DMDM hydantoin is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
DMDM hydantoin is used in the following products: cosmetics and personal care products, pH regulators and water treatment products and laboratory chemicals.

Release to the environment of DMDM hydantoin can occur from industrial use: formulation of mixtures and formulation in materials.
DMDM hydantoin is used in the following products: pH regulators and water treatment products and laboratory chemicals.
DMDM hydantoin is used in the following areas: health services and scientific research and development.

DMDM hydantoin is used for the manufacture of: chemicals.
Release to the environment of DMDM hydantoin can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.
DMDM hydantoin is a 55% solution of DMDMH in water and can be directly added to aqueous solutions.

In hot processes (such as emulsification), it is recommended to add DMDMH preferably at a temperature below 60oC during the cooling step.
DMDM hydantoin is an antimicrobial formaldehyde releaser preservative with the trade name Glydant. DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.
DMDM hydantoin is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, Rite Aid Liquid Lubricant, and skin care products.

DMDM hydantoin slowly releases formaldehyde and works as a preservative by making the environment less favorable to the microorganisms.
DMDM hydantoin is an odorless white, crystalline substance that works as an antimicrobial agent and preservative in cosmetics and personal care products.
DMDM hydantoin is a preservative in cosmetics and personal care products.

It works by slowing and preventing spoilage in products such as shampoos and hair conditioners, and in skin care products like moisturizers and makeup foundations.
DMDM hydantoin is also an antimicrobial agent used in cosmetics and personal care products.
As an antimicrobial, it can help prevent the growth of fungi, yeast and harmful bacteria that can make people sick or give them rashes, for example

DMDM Hydantoin is a white, crystalline solid.
In cosmetics and personal care products, DMDM Hydantoin is used in the formulation of shampoos, hair conditioners, skin care products, moisturizers, bath products, and makeup bases and foundations.
DMDM Hydantoin is a formaldehyde-donor preservative, that prevents or retards microbial growth, thereby protecting cosmetics and personal care products from spoilage.

DMDM hydantoin is an odorless powder or solid.
It is slightly volatile and very soluble in water.
It is a member of a group of chemicals called hydroxymethyl dimethyl hydantoins, which are formaldehyde releasers.

The hydroxymethyl dimethyl hydantoin group also includes hydroxymethyl-5,5-dimethyl hydantoin (MDM hydantoin). USE: DMDM hydantoin and MDM hydantoin are used as antimicrobial agents and preservatives in cosmetics, adhesives, air freshners, caulks, cleansers, fabric softeners, hydraulic fluids, inks, liquid detergents, metalworking cutting fluids, paints, powdered detergents, sealants, carpet shampoos, soap, stains and coatings, paper/paperboard coatings, starch solutions, textiles, and wax.
DMDM hydantoin belonging to a class of compounds known as hydantoins. Very effective broad-spectrum preservative.

DMDM hydantoin is extensively used in a variety of personal care products due to its antimicrobial properties, which help to ensure that products remain safe and free from contamination throughout their shelf life.
DMDM hydantoin helps maintain product efficacy by preventing microbial growth.

Extends shelf life and maintains product integrity.
DMDM hydantoin prevents the growth of bacteria and fungi, ensuring the product is safe to use.
DMDM hydantoin keeps products stable and free from contamination.

Prevents spoilage and ensures product safety.
Extends shelf life by inhibiting microbial growth.
DMDM hydantoin prevents contamination and potential eye infections.

DMDM hydantoin maintains product stability and hygiene.
DMDM hydantoin is a common preservative in many personal care products to ensure they remain free from microbial contamination.

DMDM hydantoin ensures stability and safety in moisturizing products.
DMDM hydantoin is used in foundations, powders, and eye makeup to prevent microbial growth.
Helps keep these products safe and effective for use over time.

DMDM hydantoin extends shelf life and maintains product safety.
In the pharmaceutical industry, DMDM Hydantoin is used to maintain the sterility and stability of various products:
Some mouthwashes and toothpaste formulations.

Due to its antimicrobial properties, DMDM Hydantoin is also used in various industrial applications:
DMDM hydantoin prevents microbial contamination that could degrade the product.
Used as a preservative in chemical formulations to prevent microbial growth.

Helps to maintain the integrity and longevity of the product by preventing microbial degradation.
DMDM hydantoin is found in several household cleaning and maintenance products:
DMDM hydantoin ensures the product remains effective over time.

Prevents microbial growth in the product, ensuring it remains effective.
Although less common due to concerns about formaldehyde release, DMDM Hydantoin can be used in food packaging materials to prevent microbial contamination and extend shelf life.
While DMDM Hydantoin is effective, its use is regulated to ensure safety:

The preservative releases small amounts of formaldehyde, which acts as an antimicrobial agent.
Regulations ensure the levels are within safe limits.
Approved by regulatory agencies like the FDA and the European Commission for use in cosmetics and personal care products within specified concentrations.

DMDM hydantoin is a concentrated industrial preservative that can be used in a broad number of H,I&I formulations to prevent product spoilage.
DMDM hydantoin is used as antimicrobial and for the preservation of personal care formulations.
DMDM hydantoin is an effective cosmetic preservative.

DMDM hydantoin one of the most advanced EPA Registered preservative on the market today.
DMDM hydantoin preservative is a cost-effective product engineered for a wide variety of household and industrial product applications to prevent product spoilage.
DMDM hydantoin is an effective cosmetic preservative. Product Data Sheet

Durable and regenerable antibacterial fabrics were prepared by using an innovative chemical technology employing a precursor biocidal agent, dimethylol dimethylhydantoin (DMDMH), iin a chemical finishing process.
DMDM hydantoin is a popular preservative with moderate sensitizing potential, it is used to control against mold, mildew, and bacterial spoilage.
This preservative is similar to imidazolidinyl urea, as both act by releasing formaldehyde into the formulation. Cosmetic expert panels have determined that Dimethyloldimethyl hydantoin has an excellent safety record for use in both leave-on and washoff cosmetic preparations.

Maximum-use concentrations are set at 0.2 percent in the u.S. and 0.6 percent in the european union.
DMDM hydantoin stands for dimethylimidazolidine, though in a listing the acronym is rarely spelled out.
DMDM hydantoin is used as preservative in a broad number of household and industrial cleaners to prevent spoilage from microorganisms

DMDM hydantoin is a formaldehyde-donor preservative, that prevents or retards microbial growth, thereby protecting cosmetics and personal care products from spoilage.
Follow this link for more information about how preservatives protect cosmetics and personal care products.
DMDM Hydantoin is a preservative and antimicrobial agent found in a wide range of cosmetics and skin-care and hair-care products.

DMDM Hydantoin's considered a “formaldehyde donor.” That means it releases a small amount of formaldehyde over time to help keep products fresh and free from contaminants.
DMDM hydantoin-releasing preservatives like DMDM hydantoin help keep beauty products from spoiling.
While DMDM hydantoin-releasing ingredients can be dangerous in high levels, these chemicals are found naturally in safe, small amounts in many foods.

DMDM Hydantoin helps your personal-care items stay fresh for long periods.
The chemical stops or slows down the growth of potentially harmful fungi, yeast, and bacteria.

Safety profile:
DMDM hydantoin, for example, the level of formaldehyde that's released is about equal to the amount found naturally in a medium-sized pear or apple.
But others suggest that formaldehyde exposure from DMDM hydantoin could have some risks.
Allergic contact dermatitis.

One study found that products with formaldehyde-releasing ingredients could cause allergic contact dermatitis or contact eczema in people allergic to formaldehyde.
And the FDA lists DMDM hydantoin as a common allergen in cosmetic products.
DMDM hydantoin's label how much formaldehyde it will release.

A class action lawsuit is pending against some shampoo companies that use MDMD hydantoin in their products.
The suit claims that the chemical may cause hair loss and scalp irritation in some people.
But there's been little, if any, research into this effect.

For some people, breathing in DMDM hydantoin can irritate their eyes, nose, and throat.
But this happens mostly with products that are heated, like certain hair straighteners used in salons.
DMDM hydantoin is considered a probable carcinogen, which means it could cause cancer.

But that's a concern only if you’re exposed to the chemical in unusually high quantities for a long time.
Experts are still unsure of all the potential long-term health effects of DMDM hydantoin.
A patch test study found that "an increase in the use of DMDM hydantoin in cosmetic products will also inevitably increase the risk of cosmetic dermatitis in consumers allergic to formaldehyde.

The safety of formaldehyde is a topic of ongoing concern, given the prevalence of formaldehyde and formaldehyde releasers in industrial uses.
Formaldehyde is considered "an important metabolic product in plants and animals (including humans), where it occurs in low but measurable concentrations.
However, long-term exposure to formaldehyde (particularly routine inhalation of its fumes) is thought to cause irritation of the eyes and mucous membranes, headaches, shortness of breath, and aggravation of asthma symptoms

DMDM hydantoin was declared a "toxic product" by the 1999 Canadian Environmental Protection Act, and the US National Toxicology Program officially classed formaldehyde as "known to be a human carcinogen in June 2011.
In the EU, the maximum allowed concentration of formaldehyde in finished products is 0.2%, and any product that exceeds 0.05% has to include a warning that the product contains formaldehyde.
Many experts believe this chemical is safe in cosmetic and hygiene items, since they release only small amounts of formaldehyde in normal use.

DESCRIPTION:

1,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin) is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM Hydantoin (DMDMH) is an organic compound belonging a class of compounds known as hydantoins.
DMDM Hydantoin (DMDMH) is used in the cosmetics industry and found in products like shampoos, hair conditioners and skin care products.


CAS: 6440-58-0
European Community (EC) Number: 229-222-8
IUPAC Name: 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
Molecular Formula: C7H12N2O4


SYNONYMS OF DMDM HYDANTOIN (DMDMH):
1,3-dimethylol-5,5-dimethylhydantoin,DMDM hydantoin,6440-58-0,1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione,DMDM Hydantoin,Dimethyloldimethyl hydantoin,Glydant,Dmdmh,1,3-Bis(hydroxymethyl)-5,5-dimethylhydantoin,1,3-Dimethylol-5,5-dimethylhydantoin,Dantoin-DMDMH,Glycoserve-DMDMH,Dantoin dmdmh 55,Dimethylol-5,5-dimethylhydantoin,Dmdmh 55,Caswell No. 273AB,2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-,dimethyloldimethylhydantoin,UNII-BYR0546TOW,EINECS 229-222-8,BYR0546TOW,EPA Pesticide Chemical Code 115501,1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione,BRN 0882348,DTXSID8035217,HSDB 7488,1,3-Di(hydroxymethyl)-5,5-dimethylhydantoin,DTXCID6015217,1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN,EC 229-222-8,1,3-DIHYDROXYMETHYL-5,5-DIMETHYLHYDANTOIN,Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-,MFCD00467199,DMDM HYDANTOIN (II),DMDM HYDANTOIN [II],Dantoguard,Dantion DMDMH 55,DMDM HYDANTION,1,3-Dihydroxylmethyl-5,5-dimethylhydantoin,SCHEMBL69185,DMDM HYDANTOIN [INCI],DMDM HYDANTION [VANDF],DMDM HYDANTOIN [VANDF],DDAC0.6%,DDAC0.15%,WSDISUOETYTPRL-UHFFFAOYSA-N,Tox21_303842,AKOS006345746,n,n'-dimethylol-5,5-dimethylhydantoin,CS-W021276,USEPA/OPP Pesticide Code: 115501,NCGC00356947-01,AS-10924,SY101650,CAS-6440-58-0,FT-0606699,NS00007210,H11751,A834743,Q5205613,W-104844,1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB],1,3-Bis (hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione,1,3 BIS(HYDROXYMETHYL)-5,5- DIMETHYLHYDANTOINDIMETHYLHYDANTOIN,1,3,BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOINDIMETHYLHYDANTOIN,1 pound not3-Bis(hydroxymethyl)-5 pound not5-dimethylimidazolidine-2 pound not4-dione,5-ethyl-1,3-dihydroxy-5-methyl-imidazolidine-2,4-dione;1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione,1,3-bis (hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione; 1,3-dimethylol-5,5-dimethyl hydantoin; Dantoin dmdmh; Dimethyloldimethyl hydantoin; DMDMH; Glydant; Glydant Plus (95:5 mixture of DMDM hydantoin and Iodo propynyl butyl carbamate); Mackgard DM; Nipaguard DMDMH; Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione; Bis(hydroxymethyl)-5,5-dimethylhydantoin; Dantion DMDMH 55; Dantoguard; Dimethylol-5,5-dimethylhydantoin; Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-; Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-.


DMDM Hydantoin (DMDMH) is an organic compound that is a member of the hydantoin family.
DMDM Hydantoin (DMDMH) functions as an antimicrobial preservative by discharging formaldehyde.
DMDM Hydantoin (DMDMH) is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria.

DMDM Hydantoin (DMDMH) can be found in products like shampoos, hair conditioners, hair gels, and skin care products from the cosmetics industry.

DMDM Hydantoin (DMDMH) is halogen and paraben free, and is highly effective against Gram-positive and Gram-negative bacteria in both leave-on and rinse-off products such as shampoo, liquid soap, shower gel, conditioner, body lotion, skin creams, sunscreen, eye cream, hair gel and make-up remover.
Due to high water solubility, DMDM Hydantoin (DMDMH) can be added to aqueous systems without heating, making it easy to use.

DMDM hydantoin acts a preservative.
DMDM Hydantoin (DMDMH) is an antimicrobial and formaldehyde releaser.
DMDM Hydantoin (DMDMH) offers protection against bacteria.

DMDM Hydantoin (DMDMH) contains low level of formaldehyde.
DMDMH EU is suitable for rinse-off products like Shampoo and liquid soap.

DMDMH is Halogen and Paraben free, and is highly effective against Gram-positive and Gram-negative bacteria in both leave-on and rinse-off products such as shampoo, liquid soap, shower gel, conditioner, body lotion, skin creams, sunscreen, eye cream, hair gel and make-up remover.
Due to high water solubility, DMDM Hydantoin (DMDMH) can be added to aqueous systems without heating, making it easy to use.


DMDM hydantoin is an antimicrobial formaldehyde releaser preservative with the trade name Glydant.
DMDM hydantoin is an organic compound belonging to a class of compounds known as hydantoins.

DMDM Hydantoin (DMDMH) is used in the cosmetics industry and found in products like shampoos, hair conditioners, hair gels, and skin care products.
DMDM hydantoin slowly releases formaldehyde and works as a preservative by making the environment less favorable to microorganisms.

Organic compound belonging to a class of compounds known as hydantoins.
DMDM Hydantoin (DMDMH) is Very effective broad-spectrum preservative.
DMDM Hydantoin (DMDMH) is Clear liquid. pH (as is): 6.5-7.5.

DMDM Hydantoin (DMDMH) has Active content 44.0 - 46.0%.
DMDM Hydantoin (DMDMH) is Easily soluble in water.


DMDM hydantoin is one the most commonly used preservative compounds in cosmetics.
DMDM hydantoin is a highly effective antimicrobial preservative and works on both Gram-positive and Gram-negative bacteria.

DMDM hydantoin is a clear colorless liquid with a mild odor, soluble in water, lower alcohols and glycols, is compatible with essentially all cosmetic ingredients, such as surfactants, emulsifiers, proteins, aloe and amines, is an excellent preservative for both leave-on and rinse-off products such as shampoos, creams, lotions, bubble baths, rinses, wipes and towelettes at concentrations up to 0.6% and in industrial applications at up to 2%.


BENEFITS OF DMDM HYDANTOIN (DMDMH):
DMDM Hydantoin (DMDMH) has Effective broad-spectrum preservation against gram-positive and gram-negative bacteria, yeast, and mold
For its high water solubility, DMDM Hydantoin (DMDMH) is particularly suggested for aqueous formulations and emulsions

DMDM Hydantoin (DMDMH) Extends shelf life of personal care products typically to 6-18 months
DMDM Hydantoin (DMDMH) is Compatible with most cosmetic ingredients
DMDM Hydantoin (DMDMH) is non-irritating and non-sensitizing
DMDM Hydantoin (DMDMH) is Environmentally friendly as it will not build up in aquatic organisms and will be broken down by microorganisms in soil.



USES OF DMDM HYDANTOIN (DMDMH):
DMDM hydantoin works as an antimicrobial in cosmetic and personal care products.
DMDM Hydantoin (DMDMH) functions as an antibacterial agent and can aid in limiting the development of harmful bacteria, yeast, and fungi.

DMDM Hydantoin (DMDMH) is a preservative that slows and prevents spoilage in items like shampoos and hair conditioners as well as in skin care items like moisturizers and foundations.
DMDM Hydantoin (DMDMH) is a "formaldehyde donor," which means that over the course of a personal care product or cosmetic product's shelf life, DMDM Hydantoin (DMDMH) releases minute quantities of formaldehyde to function as a preservative and an antimicrobial.

Personal Care:
A highly effective antimicrobial used in shampoo, hair conditioner, creams and lotions and other water-based personal care products
Preservatives:
A highly effective and water soluble antimicrobial preservative used in personal care product applications

Functions as a formaldehyde donor and is used as a preservative in cosmetic products and is active against fungi, yeasts, and bacteria.
Products preserved are of the type shampoos, skin-care products, hair conditioners, makeup, hair rinses, and cleanliness products.

DMDM Hydantoin (DMDMH) is Also used in herbicides, polymers, color photography, latex paints, floor waxes, cutting oils, adhesives, copying paper, inks.
DMDM Hydantoin (DMDMH) Contains 1% sorbitan sesquioleate as emulsifier.

Household care:
DMDM Hydantoin (DMDMH) is Widely used as preservative in detergents dishwashing liquids,and cleaning agents.
Industrial Field:
DMDM Hydantoin (DMDMH) is Used as preservative and biocide in industries like polymer, color photography, adhesives, latex paints, cutting oils, floor waxes and inks, etc.


DMDM Hydantoin (DMDMH) is a kind of broad spectrum, the highly effective antimicrobial preservative, through the release of formaldehyde against gram-positive bacteria and gram-negative bacteria, mould and yeast, and all kinds of emulsifiers, surface active agent compatibility is good.
The use of a wide range of PH and temperature ranges has been stable.

DMDM Hydantoin (DMDMH) is a low - toxic product, and the mouse red mouth LD50 is 3000MG/KG.
DMDM Hydantoin (DMDMH) Can be used in all kinds of cosmetics and personal care, the maximum use concentration is 0.6 %, can also be used in cosmetics with iodide butylmethyl-butylmethine ester.
The antisepsis of daily products such as shampoo, conditioner, shaving, foundation, lotion, cream, baby products, sunblock and cleaning agent, etc.


DMDM Hydantoin or Dimethylol dimethyl Hydantoin (DMDMH) is a derivative of formaldehyde and dimethyl hydantoin.
DMDM Hydantoin (DMDMH) was designed as an odorless alternative to formaldehyde for permanent-pressed fabrics.
Later, formulators started to incorporate it in personal care applications as a formaldehyde-releasing preservative.

DMDM Hydantoin is a preservative for use in aqueous-based personal care products with action against bacteria.
DMDM Hydantoin (DMDMH) is used as an ant-microbial and for the preservation of products such as shampoos, hand soaps, face creams, sunscreen, lotions, bubble baths, and wipes at typical use levels from 0.20 - 0.60%.


ORIGIN OF DMDM HYDANTOIN (DMDMH):
DMDM Hydantoin is produced by reacting 3 to 5 moles of formaldehyde, as the 37% by weight aqueous solution, with 1 mole of dimethyl hydantoin at 84°C.
A highly concentrated aqueous solution of the compound is prepared by reacting 2 moles of formaldehyde, as 37% formalin, with dimethyl hydantoin at 38 to 50°C, pH 8.1-8.3.



CHEMICAL AND PHYSICAL PROPERTIES OF DMDM HYDANTOIN (DMDMH):
Molecular Weight
188.18 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
XLogP3-AA
-0.2
Computed by XLogP3 3.0 (PubChem release 2021.10.14)
Hydrogen Bond Donor Count
2
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Hydrogen Bond Acceptor Count
4
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Rotatable Bond Count
2
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Exact Mass
188.07970687 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Monoisotopic Mass
188.07970687 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Topological Polar Surface Area
81.1Ų
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Heavy Atom Count
13
Computed by PubChem
Formal Charge
0
Computed by PubChem
Complexity
251
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Isotope Atom Count
0
Computed by PubChem
Defined Atom Stereocenter Count
0
Computed by PubChem
Undefined Atom Stereocenter Count
0
Computed by PubChem
Defined Bond Stereocenter Count
0
Computed by PubChem
Undefined Bond Stereocenter Count
0
Computed by PubChem
Covalently-Bonded Unit Count
1
Computed by PubChem
Compound Is Canonicalized
Yes
CAS Number, 6440-58-0
Chem/IUPAC Name:, 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
EINECS/ELINCS No:, 229-222-8
COSING REF No:, 33723
CAS Number, 6440-58-0
3D model (JSmol), Interactive image
Abbreviations, DMDMH
ChemSpider, 21482
ECHA InfoCard, 100.026.566
EC Number, 229-222-8
PubChem CID, 22947
UNII, BYR0546TOW
CompTox Dashboard (EPA), DT
Chemical formula, C7H12N2O4
Molar mass, 188.18 g/mol
Appearance, Colorless to slightly yellow transparent liquid
Effective matter content, %, 55-57
Freezing point, ℃, -11
Methyl aldehyde, %, 17.0-18.2
Free formaldehyde, %, ≤1.0
Density(25℃), 1.16g/ml



SAFETY INFORMATION ABOUT DMDM HYDANTOIN (DMDMH):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

DMDMH; Dimethyloldimethyl hydantoin; DMDM hydantoin; 1,3-bis (hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione; Glydant; DMDMH; Dantion DMDMH; 1,3-dimethylol-5,5-dimethyl hydantoin; Dantoguard; Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione; Bis(hydroxymethyl)-5,5- dimethylhydantoin; CAS NO: 6440-58-0

SYNONYMS N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine, DMEA, Jeffcat DMEA CAS NO:108-01-0

DOCOSAHEXAENOIC ACID, N° CAS : 25167-62-8 / 32839-18-2. Nom INCI : DOCOSAHEXAENOIC ACID. Nom chimique : 4,7,10,13,16,19-Docosahexaenoic acid. Ses fonctions (INCI) : Antistatique : Réduit l'électricité statique en neutralisant la charge électrique sur une surface. Agent d'entretien de la peau : Maintient la peau en bon état

SYNONYMS 1,4-Dimethylpiperazine ;CCRIS 6690; EC 203-412-0; EINECS 203-412-0; Lupetazine; N,N'-Dimethylpiperazine; NSC 41177; Texacat DMP; UNII-TF146U602L CAS NO:106-58-1

DESCRIPTION:

DMSO (Dimethyl sulfoxide) is an organosulfur compound with the formula (CH3)2SO.
DMSO (Dimethyl sulfoxide) is a colorless chemical solvent.
DMSO (Dimethyl sulfoxide) is the sulfoxide most widely used commercially.




DESCRIPTION:

DMSO (Dimethyl sulfoxide) is used as a cyroprotectant for the cryopreservation of cell lines.
DMSO (Dimethyl sulfoxide) is cell culture grade and has been tested to assure nontoxicity and sterility.
DMSO (Dimethyl sulfoxide) has been filtered through a 0.2 µm PTFE membrane and aseptically dispensed.
Each amber vial contains a 5 mL sterile aliquot.
DMSO (Dimethyl sulfoxide) has applications for cyropreservation, cell culture, cell growth, and viability.

DMSO (Dimethyl sulfoxide) is a widely used solvent that is miscible with water and a wide range of organic solvents.
DMSO (Dimethyl sulfoxide) goes by several names, including methyl sulfoxide, sulfinylbismethane, and dozens of trade names.
DMSO (Dimethyl sulfoxide) was first discovered in the late 19th century as a byproduct of the kraft process for making paper from wood pulp.
DMSO (Dimethyl sulfoxide) is a laboratory and industrial solvent for many gases, synthetic fibers, paint, hydrocarbons, salts, and natural products.
DMSO (Dimethyl sulfoxide) is aprotic, relatively inert, nontoxic, and stable at high temperatures, it is a frequently used solvent for chemical reactions.

DMSO (Dimethyl sulfoxide) is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water.
DMSO (Dimethyl sulfoxide) has a relatively high boiling point.
DMSO (Dimethyl sulfoxide) has the unusual property that many individuals perceive a garlic-like taste in the mouth after DMSO makes contact with their skin.

In terms of chemical structure, the molecule has idealized Cs symmetry.
DMSO (Dimethyl sulfoxide) has a trigonal pyramidal molecular geometry consistent with other three-coordinate S(IV) compounds, with a nonbonded electron pair on the approximately tetrahedral sulfur atom.
DMSO (Dimethyl sulfoxide) is an organic sulphurous substance obtained from wood.
DMSO (Dimethyl sulfoxide) is used topically to reduce pain and accelerate the rapid healing of burns, wounds, and musculoskeletal injuries.

DMSO (Dimethyl sulfoxide) is also used to treat painful conditions such as inflammation and headaches.
DMSO (Dimethyl sulfoxide) is a solvent produced as a by-product of the papermaking process.
Many toxic and therapeutic substances that are insoluble in water also dissolve in DMSO.
The dimethyl sulfoxide product has both aprotic and water-miscible properties, resulting in high polarity and high boiling point.
DMSO (Dimethyl sulfoxide) which has properties suitable for use without mixing with the profile, has low toxicity and good thermal stability, and is quite suitable for use in the field of need.

In addition, if you want to choose a universal solvent, dimethyl sulfoxide varieties are suitable for using in universal solvent needs, thanks to their soluble properties with many organic substances such as water, propanol, ether, ethanol and benzene.
DMSO (Dimethyl sulfoxide) is an extremely important aprotic polar solvent that is soluble in both water and organic solvents.
Widely used as solvent and reaction reagent, DMSO (Dimethyl sulfoxide) has high selective extraction ability.
DMSO (Dimethyl sulfoxide) itself has anti-inflammatory, analgesic, diuretic and sedative effects, and can be directly used as raw material and carrier of certain drugs in the pharmaceutical industry.

DMSO (Dimethyl sulfoxide) is often added to the drug as an active ingredient of analgesic drugs.
DMSO (Dimethyl sulfoxide) is used for the extraction of aromatic hydrocarbons, the reaction medium of resins and dyes, the solvent of acrylic fiber polymerization and spinning, etc.
DMSO (Dimethyl sulfoxide) is an industrial solvent produced as a chemical byproduct of paper production from wood pulp.
DMSO (Dimethyl sulfoxide) is a highly safe aprotic polar solvent that dissolves most organic and inorganic compounds.

DMSO (Dimethyl sulfoxide) is an organic compound with the chemical formula (CH₃)₂SO.
DMSO (Dimethyl sulfoxide) is a colorless liquid that is primarily used as a solvent.
DMSO (Dimethyl sulfoxide) is known for its exceptional solvent properties, as it can dissolve a wide range of organic and inorganic substances.
DMSO (Dimethyl sulfoxide) is derived from lignin, a natural compound found in trees.

DMSO (Dimethyl sulfoxide) has a high boiling point and a low freezing point, which makes it a versatile solvent for various applications.
DMSO (Dimethyl sulfoxide) is miscible with water and most organic solvents, and it has a relatively low toxicity.
DMSO (Dimethyl sulfoxide) has been used in a variety of fields, including pharmaceuticals, industrial applications, and laboratory research.
DMSO (Dimethyl sulfoxide) is often used as a solvent to dissolve and deliver medications, as it can penetrate the skin and transport substances into the body effectively.

DMSO (Dimethyl sulfoxide) is used in chemical synthesis, as a cryoprotectant for preserving cells and tissues, and as a reaction medium in organic chemistry.
It's worth noting that DMSO has both beneficial properties and potential risks.
While DMSO (Dimethyl sulfoxide) has been extensively studied and considered safe for certain applications, it can cause skin irritation and has a characteristic odor that can be bothersome to some people.
Furthermore, DMSO (Dimethyl sulfoxide) can readily carry other substances through the skin, so caution must be exercised to prevent unintended absorption of harmful or toxic compounds.

As with any chemical, DMSO (Dimethyl sulfoxide) is important to handle DMSO with care, following appropriate safety guidelines and using it only for its intended purposes.
DMSO (Dimethyl sulfoxide) can be used as organic solvent, reaction medium and organic synthesis intermediate.
DMSO (Dimethyl sulfoxide) is very versatile.
DMSO (Dimethyl sulfoxide) has high selective extraction ability, used as polymerization and condensation solvent for acrylic resin and polysulfone resin, polyacrylonitrile and acetate fiber polymerization spinning solvent, extraction solvent for separation of alkanes and aromatics, used for Aromatic hydrocarbons, butadiene extraction, acrylic fiber spinning, plastic solvents and organic synthetic dyes, pharmaceuticals and other industrial reaction medium.

In terms of medicine, dimethyl sulfoxide has anti-inflammatory and analgesic effects, and has strong penetration into the skin, so it can dissolve certain drugs, allowing these drugs to penetrate into the human body to achieve therapeutic purposes.
Utilizing the carrier properties of dimethyl sulfoxide, it can also be used as a pesticide additive.
Adding a small amount of dimethyl sulfoxide to some pesticides can help the pesticides penetrate into the plants to improve the efficacy.
DMSO (Dimethyl sulfoxide) can also be used as a dyeing solvent, dye remover, and dyeing carrier for synthetic fibers, as well as an absorbent for recycling acetylene and sulfur dioxide, a synthetic fiber modifier, antifreeze, and capacitor media, brake oil, and rare metal extraction. agent etc.

DMSO (Dimethyl sulfoxide) is used as analytical reagent and stationary liquid of gas chromatography, and also used as solvent in ultraviolet spectrum analysis.
Transdermal accelerator.
DMSO (Dimethyl sulfoxide) is one of the earliest transdermal penetration enhancers, and its penetration-enhancing properties may be related to its solvent property.
DMSO (Dimethyl sulfoxide) can denature proteins in skin keratinocytes.
DMSO (Dimethyl sulfoxide) can destroy the orderly arrangement of lipids in the stratum corneum.

DMSO (Dimethyl sulfoxide) can remove lipids and lipoproteins in the stratum corneum, and enhance the penetration of drugs.
The commonly used concentration is 30%-50%.
The freezing point of pure dimethyl sulfoxide is 18.45°C, and dimethyl sulfoxide containing 40% water will not freeze at -60°C, and dimethyl sulfoxide will release heat when mixed with water and snow.
DMSO (Dimethyl sulfoxide) is convenient to make automobile antifreeze fluid, brake fluid, and hydraulic fluid components.

Ethylene glycol antifreeze is not applicable at low temperatures exceeding -40°C, and has a lower boiling point than dimethyl sulfoxide, is poisonous, and is prone to air lock.
DMSO (Dimethyl sulfoxide) antifreeze is used in automobiles and tanks in the northern severe cold region, and can be replenished with snow instead of water at any time.
DMSO (Dimethyl sulfoxide) is also used in deicing agents, paints, various latex antifreezes, gasoline, aviation fuel antifreezes, bone marrow, blood, and organ cryogenic preservation.
DMSO (Dimethyl sulfoxide) is a chemical that dissolves many organic and inorganic substances.
DMSO (Dimethyl sulfoxide)'s available as a prescription drug and dietary supplement.



CAS NUMBER: 67-68-5

EC NUMBER: 200-664-3

MOLECULAR FORMULA: C2H6OS

MOLECULAR WEIGHT: 78.1334



USAGE:


-Biology:

DMSO (Dimethyl sulfoxide) is used in polymerase chain reaction (PCR) to inhibit secondary structures in the DNA template or the DNA primers.
DMSO (Dimethyl sulfoxide) is added to the PCR mix before reacting, where it interferes with the self-complementarity of the DNA, minimizing interfering reactions.
DMSO (Dimethyl sulfoxide) in a PCR is applicable for supercoiled plasmids (to relax before amplification) or DNA templates with high GC-content (to decrease thermostability).
For example, 10% final concentration of DMSO (Dimethyl sulfoxide) in the PCR mixture with Phusion decreases primer annealing temperature by 5.5–6.0 °C (9.9–10.8 °F).

DMSO (Dimethyl sulfoxide) is well known as a reversible cell cycle arrester at phase G1 of human lymphoid cells.
DMSO (Dimethyl sulfoxide) may also be used as a cryoprotectant, added to cell media to reduce ice formation and thereby prevent cell death during the freezing process.
Approximately 10% may be used with a slow-freeze method, and the cells may be frozen at −80 °C (−112 °F) or stored in liquid nitrogen safely.
DMSO (Dimethyl sulfoxide) is used to induce differentiation of P19 embryonic carcinoma cells into cardiomyocytes and skeletal muscle cells.



-Medicine:

Use of DMSO (Dimethyl sulfoxide) in medicine dates from around 1963, when an Oregon Health & Science University Medical School team, headed by Stanley Jacob, discovered it could penetrate the skin and other membranes without damaging them and could carry other compounds into a biological system.
In medicine, DMSO (Dimethyl sulfoxide) is predominantly used as a topical analgesic, a vehicle for topical application of pharmaceuticals, as an anti-inflammatory, and an antioxidant.
Because DMSO (Dimethyl sulfoxide) increases the rate of absorption of some compounds through biological tissues, including skin, it is used in some transdermal drug delivery systems.

DMSO (Dimethyl sulfoxide)'s effect may be enhanced with the addition of EDTA.
DMSO (Dimethyl sulfoxide) is frequently compounded with antifungal medications, enabling them to penetrate not just skin but also toenails and fingernails.
A 1978 study concluded that DMSO (Dimethyl sulfoxide) brought significant relief to the majority of the 213 patients with inflammatory genitourinary disorders that were studied.
The authors recommended DMSO (Dimethyl sulfoxide) for genitourinary inflammatory conditions not caused by infection or tumor in which symptoms were severe or patients failed to respond to conventional therapy.

In interventional radiology, DMSO (Dimethyl sulfoxide) is used as a solvent for ethylene vinyl alcohol in the Onyx liquid embolic agent, which is used in embolization, the therapeutic occlusion of blood vessels.
In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions. Without it, up to 90% of frozen cells will become inactive.
DMSO (Dimethyl sulfoxide) is particularly important in the freezing and long-term storage of embryonic stem cells and hematopoietic stem cells, which are often frozen in a mixture of 10% DMSO (Dimethyl sulfoxide), a freezing medium, and 30% fetal bovine serum.

In the cryogenic freezing of heteroploid cell lines a mixture of 10% DMSO with 90% EMEM is used.
As part of an autologous bone marrow transplant the DMSO (Dimethyl sulfoxide) is re-infused along with the patient's own hematopoietic stem cells.
DMSO (Dimethyl sulfoxide) is metabolized by disproportionation to dimethyl sulfide and dimethyl sulfone.
DMSO (Dimethyl sulfoxide) is subject to renal and pulmonary excretion.
A possible side effect of DMSO (Dimethyl sulfoxide) is therefore elevated blood dimethyl sulfide, which may cause a blood borne halitosis symptom.

DMSO (Dimethyl sulfoxide) is marketed as an alternative medicine. Its popularity as an alternative cure is stated to stem from a 60 Minutes documentary in 1980 featuring an early proponent.
One such distributor is Mildred Miller, who promoted DMSO for a variety of disorders and was consequently convicted of Medicare fraud.
There is insufficient evidence to support the hypothesis that DMSO (Dimethyl sulfoxide) has any effect, and most sources agree that its history of side effects when tested warrants caution when using it as a dietary supplement, for which it is marketed heavily with the usual disclaimer.

DMSO (Dimethyl sulfoxide) is commonly used in veterinary medicine as a liniment for horses, alone or in combination with other ingredients.
In the latter case, often, the intended function of the DMSO (Dimethyl sulfoxide) is as a solvent, to carry the other ingredients across the skin.
Also in horses, DMSO is used intravenously, again alone or in combination with other drugs.
DMSO (Dimethyl sulfoxide) is used alone for the treatment of increased intracranial pressure and/or cerebral edema in horses.
Unlike dimethyl and diallyl disulfides (which have odors resembling garlic), mono- and tri- sulfides, and similar odiferous sulfur compounds, the pure chemical DMSO (Dimethyl sulfoxide) is odorless.



APPLICATIONS:

DMSO (Dimethyl sulfoxide)DMSO is a polar aprotic solvent and is less toxic than other members of this class, such as dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, and hexamethylphosphoramide (HMPA).
DMSO (Dimethyl sulfoxide) is frequently used as a solvent for chemical reactions involving salts, most notably Finkelstein reactions and other nucleophilic substitutions.
DMSO (Dimethyl sulfoxide) is also extensively used as an extractant in biochemistry and cell biology.
Because DMSO (Dimethyl sulfoxide) is only weakly acidic, it tolerates relatively strong bases and as such has been extensively used in the study of carbanions.
A set of non-aqueous pKa values for thousands of organic compounds have been determined in DMSO (Dimethyl sulfoxide) solution.

Because of its high boiling point, 189 °C (372 °F), DMSO (Dimethyl sulfoxide) evaporates slowly at normal atmospheric pressure.
Samples dissolved in DMSO (Dimethyl sulfoxide) cannot be as easily recovered compared to other solvents, as it is very difficult to remove all traces of DMSO by conventional rotary evaporation.
One technique to fully recover samples is removal of the organic solvent by evaporation followed by addition of water and cryodesiccation to remove both DMSO and water.

Reactions conducted in DMSO (Dimethyl sulfoxide) are often diluted with water to precipitate or phase-separate products.
The relatively high freezing point of DMSO, 18.5 °C (65.3 °F), means that at, or just below, room temperature it is a solid, which can limit its utility in some chemical processes (e.g.,crystallization with cooling).
DMSO (Dimethyl sulfoxide) is a useful solvent for NMR spectroscopy, again due to its ability to dissolve a wide range of analytes, the simplicity of its own spectrum, and its suitability for high-temperature NMR spectroscopic studies.

Disadvantages to the use of DMSO (Dimethyl sulfoxide) are its high viscosity, which broadens signals, and its hygroscopicity, which leads to an overwhelming H2O resonance in the 1H-NMR spectrum.
DMSO (Dimethyl sulfoxide) is often mixed with CDCl3 or CD2Cl2 for lower viscosity and melting points.
DMSO (Dimethyl sulfoxide) is also used to dissolve test compounds in in vitro drug discovery and drug design screening programs, including high-throughput screening programs.
This is because it is able to dissolve both polar and nonpolar compounds, can be used to maintain stock solutions of test compounds (important when working with a large chemical library), is readily miscible with water and cell culture media, and has a high boiling point.

One limitation with DMSO (Dimethyl sulfoxide) is that it can affect cell line growth and viability, with low DMSO concentrations sometimes stimulating cell growth, and high DMSO (Dimethyl sulfoxide) concentrations sometimes inhibiting or killing cells.
DMSO (Dimethyl sulfoxide) is used as a vehicle in in vivo studies of test compounds too.
As with its use in in vitro studies, DMSO (Dimethyl sulfoxide) has some limitations in animal models.

In addition to the above, DMSO (Dimethyl sulfoxide) is finding increased use in manufacturing processes to produce microelectronic devices.
DMSO (Dimethyl sulfoxide) is widely used to strip photoresist in TFT-LCD 'flat panel' displays and advanced packaging applications.
DMSO (Dimethyl sulfoxide) is an effective paint stripper too, being safer than many of the others such as nitromethane and dichloromethane.



SYNTHESIS AND PRODUCTION:

DMSO (Dimethyl sulfoxide) is produced industrially from dimethyl sulfide, a by-product of the Kraft process, by oxidation with oxygen or nitrogen dioxide.
The sulfur center in DMSO (Dimethyl sulfoxide) is nucleophilic toward soft electrophiles and the oxygen is nucleophilic toward hard electrophiles.



PROPERTIES:

-Appearance: clear colorless liquid
-Solubility: H2o: miscible (completely)
-Melting Point: 18.3 degree
-InChI: InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
-InChI Key: IAZDPXIOMUYVGZ-UHFFFAOYSA-N
-Boiling Point: 189 °C (lit.)
-Flash Point: 188.6 °F - closed cup
-Purity: ≥99.9%
-Density: 1.10 g/mL (lit.)
-Solubility: Soluble in chloroform, methanol, water.
-Appearance: Clear Colourless Liquid
-Storage: Freezer
-Refractive Index: n20/D 1.479 (lit.)



CHARACTERISTICS:

-PSA: 36.28
-XLogP3: 0.8604
-Appearance: Colorless liquid
-Density: 1.100 g/cm3 at Temp: 20 °C
-Melting Point: 18.5 °C
-Boiling Point: 189 °C
-Flash Point: 189 °C(lit.)
-Refractive Index: n20/D 1.479(lit.)
-Water Solubility: Solubility in water: miscible
-Storage Conditions: Store at RT.
-Vapor Pressure: 0.42 mm Hg ( 20 °C)
-Vapor Density: 2.7 (vs air)




SPECIFICATIONS:

-CAS: 67-68-5
-EINECS: 200-664-3
-Relative density: 1.100
-melting point: 18.45
-boiling point: 189
-Flash point: 95
-ignite: 300~302℃




REACTIONS:

The methyl groups of DMSO (Dimethyl sulfoxide) are only weakly acidic, with a pKa = 35.
For this reason, the basicities of many weakly basic organic compounds have been examined in this solvent.
Deprotonation of DMSO (Dimethyl sulfoxide) requires strong bases like lithium diisopropylamide and sodium hydride.
Stabilization of the resultant carbanion is provided by the S(O)R group.

The sodium derivative of DMSO (Dimethyl sulfoxide) formed in this way is referred to as dimsyl sodium.
DMSO (Dimethyl sulfoxide) is a base, e.g., for the deprotonation of ketones to form sodium enolates, phosphonium salts to form Wittig reagents, and formamidinium salts to form diaminocarbenes.
DMSO (Dimethyl sulfoxide) is also a potent nucleophile.
In organic synthesis, DMSO (Dimethyl sulfoxide) is used as a mild oxidant.

These all involve formation of an intermediate sulfonium species.
Related to its ability to dissolve many salts, DMSO (Dimethyl sulfoxide) is a common ligand in coordination chemistry.
DMSO (Dimethyl sulfoxide) ligands are bonded to ruthenium through sulfur.
The fourth DMSO (Dimethyl sulfoxide) is bonded through oxygen.
In general, the oxygen-bonded mode is more common.

In carbon tetrachloride solutions DMSO (Dimethyl sulfoxide) functions as a Lewis base with a variety of Lewis acids such as I2, phenols, trimethyltin chloride, metalloporphyrins, and the dimer Rh2Cl2(CO)4.
The donor properties are discussed in the ECW model.
The relative donor strength of DMSO (Dimethyl sulfoxide) toward a series of acids, versus other Lewis bases, can be illustrated by C-B plots.



STORAGE:

Store at room temperature.



SYNONYM:

DMSO
67-68-5
Methyl sulfoxide
Methylsulfinylmethane
Dimethylsulfoxide
Dimethyl sulphoxide
Methane, sulfinylbis-
Demasorb
Demsodrox
Dimexide
Demavet
Domoso
Infiltrina
Somipront
Dolicur
Dromisol
Durasorb
Syntexan
Deltan
Demeso
Hyadur
sulfinylbismethane
Dermasorb
Dimethyl sulfur oxide
Doligur
Kemsol
Dipirartril-tropico
Gamasol 90
Sulfinylbis(methane)
Rimso-50
Topsym
Dimethylsulphoxide
Sclerosol
Dimethylsulfoxid
Dimethylsulfoxyde
SQ 9453
Sulfinylbis-methane
NSC-763
Rimso 50
Caswell No. 381
Dimetil sulfoxido
Topsym (rescinded)
Rimso-5
Dimexidum
(methylsulfinyl)methane
Dimethylsulphinyl
Dimetilsolfossido
CCRIS 943
Methyl sulphoxide
(CH3)2SO
DMS-90
Dimethyli sulfoxidum
Sulfoxide, dimethyl
S(O)Me2
NSC 763
methanesulfinylmethane
Domoso (Veterinary)
A 10846
HSDB 80
M 176
DMS 70
DMS 90
DMS-70
EPA Pesticide Chemical Code 000177
DTXSID2021735
Dimetilsolfossido [DCIT]
AI3-26477
dimethyl-sulfoxide
EINECS 200-664-3
UNII-YOW8V9698H
Methane, 1,1'-sulfinylbis-
SQ-9453
NSC763
YOW8V9698H
Dimethylsulfoxyde [INN-French]
CHEBI:28262
Dimetil sulfoxido [INN-Spanish]
Dimethyli sulfoxidum [INN-Latin]
(methanesulfinyl)methane
DMSO, sterile filtered
MFCD00002089
(DMSO)
C2H6OS
CHEMBL504
zymso
METHYL-13C SULFOXIDE
DTXCID401735
Dimethyl sulfoxide [USAN:INN]
Dimethyl sulfoxide, HPLC Grade
EC 200-664-3
Dimethyl sulfoxide [USAN:USP:INN:BAN]
Dimethyl sulfoxide, 99%
103759-08-6
DIMETHYL SULFOXIDE (II)
DIMETHYL SULFOXIDE [II]
methylsulfoxide
Dimethyli sulfoxidum (INN-Latin)
Rimso
DIMETHYL SULFOXIDE (MART.)
DIMETHYL SULFOXIDE [MART.]
sulfinyldimethane
Dimethyl sulpoxide
DIMETHYL SULFOXIDE (EP MONOGRAPH)
DIMETHYL SULFOXIDE [EP MONOGRAPH]
DIMETHYL SULFOXIDE (USP MONOGRAPH)
DIMETHYL SULFOXIDE [USP MONOGRAPH]
Sulphoxide, Dimethyl
Rimso 100
dimethysulfoxide
dimethlysulfoxide
dimethvlsulfoxide
dimethyisulfoxide
dimethylsulphoxid
dimethy sulfoxide
dimethylsulfoxid-
dimetyl sulfoxide
dimethyisulphoxide
dimethyl sulfoxyde
dimethyl-sulfoxyde
dimethyl suiphoxide
dimethyl-sulphoxide
dirnethyl sulfoxide
Dimethyl sulfoxixde
methylsulfmylmethane
dimethyl sulf oxide
Dimethylis sulfoxidum
Sulfinyl bis(methane)
2-Thiapropane2-oxide
DIMEHTYLSULFOXYDE
DMS (CHRIS Code)
Methyl sulfoxide (8CI)
Rimso-50 (TN)
dimethyl sulfoxide (dmso)
Dimethyl sulfoxide(DMSO)
DMSO (Sterile-filtered)
DMSO [INCI]
DMSO, Dimethyl Sulfoxide
D08HVE
DMSO (Dimethyl sulfoxide)
H3C-SO-CH3
BIDD:PXR0182
Dimethyl sulfoxide; (DMSO)
Dimethyl sulfoxide, >=99%
Dimethyl sulfoxide, anhydrous
Metano, 1,1'-sulfinilbis-
Dimethyl sulfoxide, for HPLC
Dimethyl sulfoxide; (DMSO)
Methane, sulfinylbis- (9CI)
WLN: OS1&1
DIMETHYL SULFOXIDE [MI]
DIMETHYL SULFOXIDE [INN]
DIMETHYL SULFOXIDE [JAN]
Dimethyl sulfoxide, >=99.5%
Dimethyl sulfoxide, PCR Reagent
DIMETHYL SULFOXIDE [HSDB]
DIMETHYL SULFOXIDE [USAN]
Dimethyl sulfoxide, ACS reagent
G04BX13
M02AX03
Methyl sulfoxide, >=99%, FG
Dimethyl sulfoxide, p.a., 99%
DIMETHYL SULFOXIDE [VANDF]
Dimethyl sulfoxide, LR, >=99%
Pharmakon1600-01506122
AMY14894
CS-B1637
Dimethyl sulfoxide (JAN/USP/INN)
DIMETHYL SULFOXIDE [USP-RS]
DIMETHYL SULFOXIDE [WHO-DD]
HY-Y0320
METHYLSULFINYLMETHANE [FHFI]
Tox21_300957
BDBM50026472
HB3262
NSC760436
STL264194
Dimethyl sulfoxide, AR, >=99.5%
AKOS000121107
CCG-213615
DB01093
DIMETHYL SULFOXIDE [GREEN BOOK]
Dimethyl sulfoxide, analytical standard
LS-1568
NSC-760436
CAS-67-68-5
DIMETHYL SULFOXIDE [ORANGE BOOK]
MRF-0000764
USEPA/OPP Pesticide Code: 000177
(methanesulfinyl)methanedimethyl sulfoxide
Dimethyl sulfoxide, for molecular biology
Dimethyl sulfoxide; AIF; CE0; MS2Dec
NCGC00163958-01
NCGC00163958-02
NCGC00163958-03
NCGC00254859-01
8070-53-9
Dimethyl sulfoxide, anhydrous, >=99.9%
Dimethyl sulfoxide, HPLC grade, 99.9%
Dimethyl Sulfoxide [for Spectrophotometry]
Dimethyl sulfoxide, for HPLC, >=99.5%
Dimethyl sulfoxide, for HPLC, >=99.7%
D0798
D1159
D5293
Dimethyl sulfoxide, ACS reagent, >=99.9%
Dimethyl sulfoxide, AldraSORB(TM), 99.8%
FT-0625099
FT-0625100
EN300-24544
D01043
Dimethyl sulfoxide, >=99.6%, ReagentPlus(R)
Dimethyl sulfoxide, ReagentPlus(R), >=99.5%
AB01563146_01

SYNONYMS DADMT; 2,4-Diamino-3,5-dimethylthiotoluene; 3,5-Dimethylthio-2,4-toluenediamine; Ethacure 300; CAS NO:106264-79-3

DIETHYLHEXYL SODIUM SULFOSUCCINATE, N° CAS : 577-11-7 - Docusate de sodium, Nom INCI : DIETHYLHEXYL SODIUM SULFOSUCCINATE, Nom chimique : Docusate sodium, N° EINECS/ELINCS : 209-406-4, Additif alimentaire : E480. Ses fonctions (INCI), Agent nettoyant : Aide à garder une surface propre. Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Hydrotrope : Augmente la solubilité d'une substance qui est peu soluble dans l'eau.Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Noms français : 1,4-BIS(2-ETHYLHEXYL) SODIUM SULFOSUCCINATE BIS(2-ETHYLHEXL) SULFOSUCCINATE SODIUM SALT BIS(2-ETHYLHEXYL) S-SODIUM SULFOSUCCINATE BIS(2-ETHYLHEXYL) SODIUM SULFOSUCCINATE BUTANEDIOIC ACID, SULFO-, 1,4-BIS(2-ETHYLHEXYL) ESTER, SODIUM SALT DI(2-ETHYLEHEXYL)SULFOSUCCINATE SODIUM SALT DI(2-ETHYLHEXYL)SULFOSUCCINATE SODIUM SALT DI(2-ETHYLHEXYL)SULFOSUCCINIC ACID, SODIUM SALT Dioctyl sodium sulfosuccinate DIOCTYL SULFOSUCCINATE SODIUM DIOCTYL SULFOSUCCINATE SODIUM SALT Dioctylsulfosuccinate de sodium Docusate de sodium SODIUM 1,2-BIS(2-ETHYLHEXYLOXYCARBONYL)-1-ETHANESULFONATE SODIUM 1,4-BIS(2-ETHYLHEXYL) SULFOSUCCINATE SODIUM BIS(2-ETHYLHEXYL) SULFOSUCCINATE SODIUM DI(2-ETHYLHEXYL) SULFOSUCCINATE SODIUM DIOCTYL SULFOSUCCINATE SODIUM, DIOCTYL SULFOSUCCINATE DE SUCCINIC ACID, SULFO, 1,4-BIS(2-ETHYLHEXYL) ESTER, SODIUM SALT Sulfosuccinate de dioctyle et de sodium Sulfosuccinate de sodium et de bis(éthyl-2 hexyle) SULFOSUCCINIC ACID BIS(2-ETHYLHEXYL)ESTER SODIUM SALT SULFOSUCCINIC ACID, DIISOOCTYL ESTER, SODIUM SALT Noms anglais : Dioctyl sodium sulfosuccinate Sodium dioctylsulfosuccinate Sodium docusate Utilisation : Le dioctylsulfosuccinate de sodium est un surfactant utilisé dans de nombreuses formulations industrielles. Il est aussi utilisé dans plusieurs produits pharmaceutiques dont les laxatifs et dans la fabrication de cosmétiques et d'aliments.

DOCOSANOL = BEHENYL ALCOHOL


CAS Number: 661-19-8
EC Number: 211-546-6
Molecular Formula: C22H46O


Docosanol is a saturated 22-carbon aliphatic alcohol with antiviral activity.
Docosanol is a natural product found in Populus tremula, Hypericum laricifolium, and other organisms with data available.
Docosanol is easily soluble in methanol, diethyl ether, n-octanol.
Docosanol is partially soluble in hot water, acetone.


Docosanol is very slightly soluble in cold water.
Docosanol, also known as behenyl alcohol, is a saturated fatty alcohol containing 22 carbon atoms, used traditionally as an emollient, emulsifier, and thickener in cosmetics.
In July 2000, docosanol was approved for medical use in the United States as an antiviral agent for reducing the duration of cold sores.
Docosanol is an over-the-counter medication.


Docosanol is an aliphatic alcohol that inhibits fusion between the plasma membrane and the HSV envelope, thereby preventing viral entry into cells and viral replication.
Docosanol is a unique chemical compound also known as behenyl alcohol.
Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.


Docosanol can reduce the duration of symptoms attributed to cold sores and fever blisters caused by HSV, however, docosanol is not virucidal.
A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV).
Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.


Docosanol is a saturated fatty alcohol as an emollient, emulsifier, and thickener.
Docosanol is a fatty alcohol (the non-drying type with a long oil loving chain of 22 carbon atoms) that is used to increase the viscosity of the formula and it also helps the oily and the watery parts to stay nicely mixed together (called emulsion stabilizing).
Docosanol is a natural, vegetable source long chain fatty alcohol used to regulate viscosity in formulations.


Docosanol is produced from vegetable sources and is derived from non-genetically modified plants.
Docosanol is GMO-free (not containing genetically modified DNA).
Docosanol is an opacifying ingredient which gives excellent spreadability to cosmetic products as well as being an emulsifier and antimicrobal
Docosanol is a saturated fatty acid naturally derived from vegetable sources such as corn.


Docosanol has 22 carbons and is also known as Docosanol (the key ingredient in formulations for herpes).
Docosanol has a very special thickening property to allow the final product to have a more desirable and spreadable texture.
Whilst opacity and thickness can be seen as a matter of persona preference, Docosanol enhances the spreadability of the final product and thus the effectiveness of the final cosmetic formulations.


Docosanol is a vegan ingredient, derived from vegetable sources.
Docosanol, also known as 1-docosanol, is a synthetic or plant-derived thickening agent and emulsifier used in cosmetics.
Docosanol also serves as a hydrating ingredient.
Docosanol’s considered a fatty alcohol not related to drying forms of alcohol.


In Docosanol's raw form it is a white, waxy solid.
The Cosmetic Ingredient Review panel has deemed Docosanol to be safe for topical application as used in cosmetics.
Docosanol, which is a 22-carbon saturated fatty alcohol that inhibits intracellular penetration of lipid enveloped viruses, is approved as a cream for the treatment of herpes labialis.


Behenyl alcohol or Docosanol is a fatty alcohol.
Docosanol makes the skin soft and its feel remains non-greasy after application.
Docosanol is authorized in organic.
Docosanol is a saturated fatty alcohol of vegetable origin, used to regulate viscosity in formulations.


Docosanol produces elegant emulsions and gives the skin a soft, velvety feel.
Docosanol is considered a fatty, non-drying form of alcohol
Docosanol is also known as 1-docosanol
Docosanol has been ruled safe as used in cosmetics


The CIR (Cosmetic Ingredient Review) in an annual report published in 2008, concluded that fatty alcohols are safe.
Docosanol is very safe; mild for skin; viscosity does not change much with temperature and thus forms a stable emulsion
Docosanol is the largest fatty alcohol in this group with 22 carbons.
Docosanol blend was produced to reduce the crystalline structure which enhances the functionality.


The Cosmetic Ingredient Review panel has deemed Docosanol to be safe for topical application as used in cosmetics.
Docosanol is a saturated fatty alcohol containing 22 carbon atoms, used traditionally as an emollient, emulsifier, and thickener in cosmetics.
Docosanol is a large fatty straight-chain alcohol.
Docosanol’s considered a fatty alcohol not related to drying forms of alcohol.


In it's raw form Docosanol is a white, waxy solid.
Newly-released data on the Docosanol Market shows that global sales are expected to reach around US$ 158.5 Mn by the end of 2022, registering a Y-o-Y growth of approximately 1.4 %.
Docosanol is a plant-based emulsifier and thickening agent.


Docosanol is considered a fatty alcohol which is by far the best type of alcohol for skin care and cosmetics.
This is because Docosanol acts as both an emulsifier and emollient.
As an emulsifier, Docosanol, holds the water and oils together in cosmetics.
Docosanol is typically made from the fats in vegetable oils.


Docosanol is actually a really common ingredient, and unfortunately can be made synthetically as well.
Docosanol is important to look out for natural Docosanol in your products, but all in all, this is one of the best fatty alcohols and is healthy for your skin.
Docosanol is considered a fatty, non-drying form of alcohol


Docosanol is also known as 1-docosanol has been ruled safe as used in cosmetics
Docosanol helps to retain skin moisture, improving the hydrated look of the ski, forming a natural protective layer.
Docosanol does not leave a greasy feel after application in the way other emollients can, instead leaving the skin feeling soft and hydrated.
Docosanol is a vegan ingredient, derived from vegetable sources.


Docosanol is biocompatible (COSMOS standard).
Docosanol is a consistency giving agent.
Docosanol is a hydrophilic wax.
Docosanol is a saturated 22-carbon aliphatic alcohol with antiviral activity.


Docosanol has a distinct mechanism of action and inhibits fusion between the plasma membrane and the herpes simplex virus envelope, thereby preventing viral entry into cells and subsequent viral activity and replication.
Docosanol is a natural product found in Populus tremula, Hypericum laricifolium, and other organisms with data available.
Docosanol is an emulsifier that also keeps the oil and liquid parts of a solution from separating.


Docosanol, also known as docosanol, is a colorless, waxy solid.
Docosanol’s usually found naturally from vegetables, in their long-chain fatty acid mixture.
Docosanol has one characteristic of making a layer over water to minimize evaporation.
This is particularly useful in hot weather.


Same way it does not let moisture evaporate from skin or hair’s surface, thus act as emollient.
Docosanol is similar to other members of the behenic group a good emulsion stabilizer.
Docosanol is a saturated fatty alcohol usually obtained from vegetable sources and non-genetically modified plants.
Docosanol is a natural vegetable source saturated fatty alcohol used to regulate viscosity in formulations.


Docosanol is saturated fatty alcohol with 22 carbons.
Fatty alcohols are a group of ingredients that are often misunderstood, mostly due to their name.
Fatty alcohols have a high molecular weight, straight-chain primary alcohols derived from natural fats and oils.
Docosanol is derived from vegetable sources such as corn, but it can also be synthetically produced.


Docosanol or behenyl alcohol is of natural origin and is part of the family of fatty alcohols.
The INCI names "alcohol" which are preceded by a term ending with the suffix "-yl" are fatty alcohols .
Example : Cetyl alcohol or myrstyl alcohol.
Docosanol is found in vegetables, in the mixture of long chain fatty acids.


Docosanol is colorless and waxy.
Docosanol is a long-chain primary fatty alcohol that is docosane substituted by a hydroxy group at position 1.
Docosanol has a role as an antiviral agent.
Docosanol is a long-chain primary fatty alcohol and a fatty alcohol 22:0.


Docosanol derives from a hydride of a docosane.
Behenyl Alcohol, also known as docosanol, is a large fatty straight-chain alcohol.
Docosanol is a white, waxy solid that functions as a thickener, binding agent, solubilizer and gellant for low viscosity fluids.
Docosanol contains a small amount of fatty alcohols for unique properties while formulating.


Docosanol has a heavier cream.
Docosanol gives a thicker creamy texture
Docosanol is a natural vegetable source saturated fatty alcohol used to regulate viscosity in formulations.
Docosanol is a long chain linear fatty alcohol (with 22 carn atoms) derived from natural raw materials such as rapeseed or coconut oils.
Readily biodegradable and metabolized as regular fat, Docosanol is safe for the skin and the environment.



USES and APPLICATIONS of DOCOSANOL:
Docosanol has a distinct mechanism of action and inhibits fusion between the plasma membrane and the herpes simplex virus envelope, thereby preventing viral entry into cells and subsequent viral activity and replication.
Docosanol is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help heal sores faster.


Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters).
A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV).
Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.


Docosanol is an antiviral used to treat orofacial herpes sores.
Docosanol is used to treat the symptoms of herpes simplex virus infections around the mouth.
Although docosanol will not cure herpes simplex, it may help relieve the pain and discomfort and may help the sores (if any) heal faster.
Docosanol is a generic over-the-counter topical drug used to treat cold sores and fever blisters due to herpes simplex infection.


Docosanol is used to treat "cold sores/fever blisters" (herpes labialis).
Docosanol can speed up healing of the sores and decrease symptoms (such as tingling, pain, burning, itching).
Docosanol works by blocking the virus that causes the cold sores (herpes simplex) from entering the healthy skin cells and growing in number.
This medication does not cure herpes and does not prevent passing the infection to someone else.


Docosanol does not prevent a future occurrence.
Treats fever blisters and cold sores caused by herpes simplex.
This medicine is an antiviral.
Docosanol is used treats cold sores/fever blisters on the face or lips shortens healing time and duration of symptoms: tingling, pain, burning, and/or itching


Docosanol prevents herpes simplex virus from entering cells by preventing viral particles from fusing with cell membranes.
Docosanol treats cold sores/fever blisters, Shortens healing time.
Docosanol is used healing cream for treating cold sores and fever blisters on the face or lips.
Docosanol shortens the duration of tingling, pain, burning and itching symptoms


Delivers best results when treated at the first tingle.
Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters).
Docosanol speeds the healing of cold sores and fever blisters on the face or lips.
Docosanol also relieves the accompanying symptoms, including tingling, pain, burning, and itching.


Docosanol works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV.


Docosanol is used for the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters).
Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.
Docosanol is an over-the-counter medication used to treat cold sores and fever blisters.
Docosanol belongs to a group of drugs called antivirals.


Docosanol helps to protect healthy cells from the cold sore infection.
Docosanol shortens healing time and duration of symptoms of cold sores/fever blisters.
Docosanol treats cold sores and fever blisters in adults and children 12 years of age and older.
When used early, it could knock out your cold sore in 2½ days.


Docosanol topical (for the skin) is used to treat cold sores on the face and lips.
Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.
Docosanol functions as a thickener and stabilizer and may be used as a co-emulsifier.


Docosanol may be used in anhydrous formulations such as ointments, body butters and scrubs.
Docosanol has high antimicrobial activity and is used in cosmetics to aid skin feel and hydration hydration, manage hair manageability, as an effective co-emulsifier, texture adjustment and improved spreadability of your cosmetic formulation.
Docosanol is primarily used as an emulsifier, emollient, thickener and opacifying ingredient and is found mainly in face moisturisers and body lotions, it can however also be used in deodorant, lipstick, foundation and hair care products.


Docosanol has a very high antimicrobial activity, hence its use in herpes formulations.
Docosanol is compatible with most other cosmetic ingredients in cosmetic formulations and as such can be used as a co-emulsifier with other emulsifiers to increase stability and skin feel.
Docosanol tends to have a stabilising effect on emulsions.


Docosanol helps to retain skin moisture, improving the hydrated look of the ski, forming a natural protective layer.
Docosanol does not leave a greasy feel after application in the way other emollients can, instead leaving the skin feeling soft and hydrated.
Docosanol is used as a thickener and moisturizing ingredient in cosmetics.
Docosanol acts an emollient in hair care products, helping to increase the moisture content in the hair and improve manageability.


When used in hair care formulas, Docosanol can be used to increase the slip of hair and thus Docosanol is useful in detangling hair care formulations.
Docosanol is used improving texture, improve spreadability.
Docosanol adds texture and thickness without increasing greasiness.


Docosanol is used in cosmetics as an emulsifier to allow the oily parts to remain well mixed with other liquids.
Docosanol is also used as a thickener, to increase the foaming capacity of a product or to improve the stability of a foam.
In medicines, Docosanol is used as an antiviral against herpes.
Docosanol is used as a thickener and moisturising ingredient in cosmetics.


Docosanol acts as a thickener and stabilizer and can be used as a co-emulsifier.
Docosanol can be used in water-in-oil emulsions, oil-in-water emulsions and anhydrous formulations such as ointments, body butters and peelings.
Docosanol functions as a thickener, binding agent, solubilizer and gellant.
Docosanol can be used in color cosmetics, sunscreens, skin and hair care.


Docosanol uses include SPF products, mascaras, sticks, lip balms, emulsions, hair products and antiperspirants.
This highly desirable, long chain fatty alcohol, Docosanol is used to thicken and stabilize formulations.
Docosanol can also serve as a co-emulsifier in some formulations.
Docosanol will produce elegant emulsions and impart a soft, velvety feel to the skin.


Docosanol can be used in water-in-oil emulsions, oil-in-water emulsions, and anhydrous formulations-----cream, lotion, ointment, body butter, salt scrubs.
In cosmetic and skin care formulations, it is used as an opacifying ingredient, thickener, and emulsifier.
As an opacifying agent, Docosanol is used to reduce the clear or transparent appearance of cosmetic products.


Docosanol's thickening property allows products to achieve a more desirable, spreadable texture.
Docosanol also works as an emulsifier to prevent the oil and water phases of a product from separating.
This works to improve the consistency of a product, which enables an even distribution of topical skincare benefits.
Docosanol, also known as 1-docosanol, is a synthetic or plant-derived thickening agent and emulsifier used in cosmetics.


Docosanol also serves as a hydrating ingredient.
Docosanol is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help heal sores faster.
A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV).


Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Docosanols other functions include altering the thickness of a liquid, increasing foaming capacity, and stabilizing foams.
When applied to the skin, it gives it a smooth feel and helps prevent moisture loss.


Many products incorporate this ingredient because of its unique sensory properties and non-greasy feel after application.
Docosanol's mainly used in face/body lotions and creams, but can also be found in deodorant, lipstick and foundation.
Docosanol is used as viscosity increasing agent.
Docosanol is used in formulations such as ointments, scrubs, and body butter.


Docosanol is used to thicken and stabilize formulations.
Docosanol can also serve as a co-emulsifier in some formulations.
Docosanol can be used in water-in-oil emulsions, oil-in-water emulsions, and anhydrous formulations cream, lotion, ointment, body butter, salt scrubs.


Docosanol is widely used in cosmetic and skincare products, such as deodorants, lotions, lipsticks, foundations, ointments, body butter and scrubs, as a binding, thickening, emulsifying and opacifying agent.
Docosanol aids in reducing the transparency of the product and thickening the consistency to obtain a spreadable texture.
Docosanol is applied to the face and body for nourishing the skin and preventing moisture loss.


Docosanol is used in cosmetic O/W emulsions for viscosity regulation.
Docosanol use application in antiperspirants & deodorants, sun-care (after-sun, sun-protection, self-tanning), color-, body & face care and face cleansing formulations.
Docosanol is also used in baby care & cleansing and conditioning formulations.


To achieve the correct texture with your formulation, the addition of just 0.5% Docosanol can help radically change the texture and feel of your cosmetic product.
Docosanol adds texture and thickness without increasing greasiness.
Docosanol is an opacifying ingredient which gives excellent spreadability to cosmetic products as well as being an emulsifier in cosmetics to aid skin feel and hydration, manage hair manageability, as an effective co-emulsifier, texture adjustment and improved spreadability of your cosmetic formulation.


Docosanol is primarily used in face moisturizers and body lotions, but can also be found in deodorant, lipstick, foundation, and hair care products.
Docosanol helps the skin to retain moisture, improving the hydrated look of the skin.
Docosanol also has many benefits to the texture and sensory feel of products.
Docosanol functions as a thickener and stabilizer and may be used as a co-emulsifier.


Docosanol may be used in water-in-oil emulsions, oil-in-water emulsions, and anhydrous formulations such as ointments, body butters and scrubs.
Docosanol will produce elegant emulsions and impart a soft, velvety feel to the skin.
Despite having alcohol in their name, fatty alcohols actually help to effectively condition and soften the skin and hair.
Docosanol is a fatty alcohol used in skincare and cosmetic products to help soften the skin and improve the texture and consistency of the formulation.


Docosanol's main four uses are as an opacifying ingredient, thickener, emollient, and emulsifier.
Docosanol is present in many treatments, such as perfumes, body care or hair coloring.
Docosanol is used as a preservative to protect the mixture from contamination.
Docosanol also neutralizes bacteria, calms inflammation and deodorizes.


In cosmetic and skin care formulations, Docosanol is used as an opacifying ingredient, thickener and emulsifier.
Docosanol also works as an emulsifier to prevent the oil and water phases of a product from separating.
Being a mixed form of fatty acids that is used to increase a formula's viscosity, to stabilize emulsions, as a binder while leaving a soft, smooth feel to the skin.


Docosanol Can be used in almost any formulation.
Docosanol is a saturated fatty alcohol.
Docosanolis used as an emollient, emulsifier, and thickener in cosmetics.
Docosanol is used to increase the stability of emulsion, increase the viscosity of creams or lotions, help add moisturizer to the formula, giving the formula a butter-like texture, giving it a smooth feel.


Docosanol is a thickener or thickener in the cream, looks like flakes when mixed with Cream Maker Any kind will add texture to the cream.
Docosanol is occlusive emollient or helps to coat the skin.
To reduce the chance of water loss of the skin, Docosanol is a moisturizer in the body.
Docosanol must be used with any type of Cream Maker because Docosanol cannot combine water and oil.


Docosanol functions as a thickener and stabilizer and may be used as a co-emulsifier.
Docosanol may be used in water-in-oil emulsions, oil-in-water emulsions, and anhydrous formulations such as ointments, body butters and scrubs.
Docosanol will produce elegant emulsions and impart a soft, velvety feel to the skin.
Docosanol is a waxy solid at room temperature used in skin and hair care formulations as a thickener, emulsifier, binding agent, solubilizer, and gallant.


Thanks to excellent emulsifying properties, Docosanol produces stable emulsions which stay unchanged in temperature changes (including viscosity) while exhibiting superior mildness and safety for the skin.
In addition, Docosanol thickens and improves the sensory profile of the application, imparting a velvety-soft feel to the skin.
Combined with the same length fatty acid, Behenic acid, it forms waxy oleo-gels with a pleasant feel that can dissolve and carry natural oils and active ingredients.


In decorative cosmetics, Docosanol is used as a pigment dispersing and wetting agent that helps ease spreading and sticking on the skin's surface.
In addition, Docosanol is a perfect base for dispersing abrasive particles in mechanical exfoliators.
Docosanol is widely used in facial creams, masks, and lotions, as well as in hair, eye, and body care applications.


-Cosmetic effect of Docosanol:
The so-called emollient fat.
When used in skin and hair care products, Docosanol creates an occlusive layer (film) on their surface, which prevents excessive evaporation of water from the surface (this is an indirect moisturizing effect), thus conditioning the skin and hair.
Oils, softens, smoothes and tones the skin.
Docosanol has an antiviral effect, which is why it is used during the treatment of herpes.
Docosanol accelerates the healing of blisters.


-Pharmacodynamics
*Docosanol is a saturated 22-carbon aliphatic alcohol which exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV).
*Docosanol speeds the healing of cold sores and fever blisters on the face or lips.
*Docosanol also relieves the accompanying symptoms, including tingling, pain, burning, and itching.
*Docosanol cannot, however, prevent cold sores or fever blisters from appearing.


-Uses of Docosanol of Medicine:
Docosanol belongs to the family of medicines called antivirals.
Antivirals are used to treat infections caused by viruses.
Usually they work for only one kind or group of virus infections.


-Docosanol can be used neat or as derivatives in a wide range of cosmetic formulations for instance:
• Hair Care
• Skin Care
• Sun Care
• Colour Cosmetics
• Antitranspirants and Deodorants


-Applications of Docosanol include but are not limited to:
*Lotions and creams
*Ointments
*Body butters
*Scrubs


-Consumer Products:
*Blends
*Detergents
*Ethoxylation


-Household Cleaners of Docosanol:
*Sulfonation
*Surfactants
*Food & Pharma
*Nutritional Supplements
*Lubricants, Fluids & Oilfield
*Industrial


-Personal Care uses of Docosanol:
*Blends
*Emollients
*Emulsifiers
*Esters


-Products to use Docosanol in:
*Moisture Cream
*Moisture Lotion
*Body Butter
*Cleanser
*Face Mask
*Skin Peels
*Shower Gel
*Shampoo
*Conditioner


-Cosmetic Uses of Docosanol:
*binding agents
*emulsion stabilisers
*skin conditioning - emollient
*viscosity controlling agents


-Docosanol is used in treatments as:
*Emulsifying agent:
Docosanol allows oily ingredients to be mixed with aqueous ingredients.
Docosanol is also used as an emulsion stabilizer , that is to say, it promotes the emulsion while stabilizing it and improving its conservation;
*Thickening agent:
Docosanol is used in treatments to increase the "foaming" capacity of the treatment or to improve the stability of the foam;
*Emollient agent:
Docosanol softens and softens the skin;
*Verification Control Agent:
Docosanol is used to increase or decrease care verification.



MECHANISM OF ACTION:
Docosanol works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV.
Docosanol belongs to the family of medicines called antivirals.
Antivirals are used to treat infections caused by viruses.
Usually they work for only one kind or group of virus infections.



ALTERNATIVE PARENTS of DOCOSANOL:
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS of DOCOSANOL:
*Fatty alcohol
*Organic oxygen compound
*Hydrocarbon derivative
*Primary alcohol
*Organooxygen compound
*Alcohol
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of DOCOSANOL:
Molecular Weight: 326.6
Chemical formula: C22H46O
Molar mass: 326.609 g·mol−1
Melting point: 70 °C; 158 °F; 343 K
Boiling point: 180 °C; 356 °F; 453 K at 29 Pa
log P: 10.009
Molecular Weight: 326.6
XLogP3: 10.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 20
Exact Mass: 326.354866087
Monoisotopic Mass: 326.354866087

Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 23
Formal Charge: 0
Complexity: 190
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Color: White
Melting Point: 68.0°C to 72.0°C
Flash Point: 227°C
Assay Percent Range: 97.5% min. (GC)

Infrared Spectrum: Authentic
Linear Formula: CH3(CH2)21OH
Beilstein: 01, 431
Merck Index: 15, 3444
Solubility in water: insoluble.
Formula Weight: 326.61
Physical Form: Pellets or Tablets
Percent Purity: 98%
Viscosity: 7.5 mPa.s (80°C)
Chemical Name or Material: 1-Docosanol, 0.98
Min. Purity Spec: 98% (GC)
Physical Form (at 20°C): Solid
Melting Point: 68-72°C
Boiling Point: 180°C(0.2mmHg)
Long-Term Storage Store long-term in a cool, dry place

Appearance Form: powder
Color: white
Odor: No data available
Odor Threshold: No data available
pH: No data available
Meltin point/freezing point:
Melting point/range: 65 - 72 °C
Initial boiling point and boiling range: 180 °C at 0,29 hPa
Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure. No data available

Vapor density: No data available
Relative density: 0,854 at 20 °C
Water solubility: 0,001 g/l at 23 °C
Partition coefficient:
n-octanol/water: log Pow: 8,3 at 20 °C
Autoignition temperature: 256 °C
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Surface tension 66,5 mN/m at 25 °C



FIRST AID MEASURES of DOCOSANOL:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DOCOSANOL:
-Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of DOCOSANOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of DOCOSANOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DOCOSANOL:
-Precautions for safe handling:
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of DOCOSANOL:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
1-DOCOSANOL
Docosanol
docosan-1-ol
Behenyl alcohol
661-19-8
Behenic alcohol
n-Docosanol
Abreva
Docosyl alcohol
Tadenan
Lidavol
Stenol 1822
Lanette 22
Docosanol
Lidakol
Stenol 1822A
Nacol 22-97
IK 2
30303-65-2
NAA 422
NSC 8407
Docosanol
NSC-8407
9G1OE216XY
CHEBI:31000
NCGC00159370-02
Docosanol
Erazaban
Herepair
IK.2
Healip
Cachalot BE-22
Abreva (TN)
HSDB 5739
Loxiol VPG 1451
EINECS 211-546-6
BRN 1770470
UNII-9G1OE216XY
AI3-36489
CCRIS 8943
n-Docosan-1-ol
C22 Alcohol
Docosanol-(1)
MFCD00002939
1-Docosanol, 98%
DOCOSANOL
DSSTox_CID_7286
N-DOCOSANOL
DOCOSANOL
EC 211-546-6
DOCOSANOL
DSSTox_RID_78387
DSSTox_GSID_27286
SCHEMBL51925
4-01-00-01906
BEHENYL ALCOHOL
DOCOSANOL
CHEMBL1200453
DTXSID4027286
NSC8407
HMS2093P22
Pharmakon1600-01505729
HY-B0222
ZINC6920384
Tox21_111611
LMFA05000008
NSC759235
s1637
AKOS015902887
CCG-213539
DB00632
NSC-759235
Behenyl alcohol
AI3-36489
Behenic alcohol
1-Docosanol
Docosyl alcohol
IK-2
Tadenan
NCGC00159370-03
NCGC00159370-04
NCGC00159370-05
1-Docosanol, purum, >=97.0% (GC)
AC-19852
CAS-661-19-8
SBI-0206938.P001
A8416
AM20100601
D0964
FT-0622609
D03884
D70615
AB01563123_01
AB01563123_02
SR-05000001915
Q3033497
SR-05000001915-1
A3D72D45-625E-49B5-B0FC-394010B3485D
Docosan-1-ol
Other names
Behenic alcohol
Behenyl alcohol
Cachalot BE-22
1-Docosanol
n-Docosanol
Docosyl alcohol
Emery 3304
Loxiol VPG 1451
1-Docosonol
Abreva
Behenic Alcohol
Behenyl 80 Alcohol
Behenyl Alc. 80
Behenyl Alcohol
Conol 2265
Conol 2280
Docosanol
Docosyl Alcohol
Hainol 22S
IK 2
IK 2 (alcohol)
Kalcohl 220
Kalcohl 22080
Kalcol 22080
Lanette 22
NAA 422
NSC 8407
Nacol 22-97
Nacol 22-98
Nacol C 22
Stenol 1822
Stenol 1822A
Tadenan
Toho BH 65
n-Docosanol
1-Docosanol
Abreva
Behenic alcohol
Behenyl alcohol
Docosyl alcohol
N-Docosanol
Tadenan
IK.2
Docosanol
1-Docosonol

Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS).
Salts of this anion, especially docusate sodium, are widely used in medicine as laxatives and as stool softeners, by mouth or rectally.
Some studies claim that docusate is not more effective than a placebo for improving constipation.

CAS: 577-11-7
MF: C20H37O7S.Na
MW: 444.56
EINECS: 209-406-4

Synonyms
AEROSOL OT;AEROSOL OTB;AEROSOL(R) OT;AEROSOL(R) OT-100;AEROSOL(TM) OT;1,4-bis(2-ethylhexyl)sodiumsulfosuccinate;Sulfosuccinic acid, dioctyl ester, sodium salt;DIETHYLHEXYL ;SODIUM SULFOSUCCINATE;Docusate sodium;577-11-7;Dioctyl sodium sulfosuccinate;Dioctyl sulfosuccinatesodiumsalt;AerosolOT;Dioctylal;Diotilan;Disonate;Molatoc;Regutol;Velmol;Doxol;Nevax;Constonate;Dialose;Doxinate;Soliwax;Molcer;Waxsol;Adekacol EC 8600;Docusate (Sodium);Mervamine;Clestol;Defilin;Obston;Requtol;Docusate sodium salt;Diox;Modane Soft;Alcopol O;Sulfimel DOS;Manoxal OT;Manoxol OT;Aerosol AOT;Aerosol GPG;Wetaid SR;Aerosol OT-A;Colace;Laxinate 100;Sanmorin OT 70;Triton GR 7;Triton GR-5;Aerosol OT 70PG;Aerosol OT 75
;Celanol DOS 65;Celanol DOS 75;Coloxyl;Comfolax;Coprola;Dioctyl;Docolace;Docuprene;Dulcivac;Eurowet;Humifen WT 27G;Solusol-75%;Silace;Bloat treatment;Docusato sodico;Nikkol OTP 70;Aerosol A 501
;Alkasurf SS-O 75;Bis(2-ethylhexyl) sulfosuccinate sodium salt;Solusol-100%;Docusate sodique;Nekal WT-27;Berol 478;Docusatum natricum;Empimin op70;Sanmorin ot 70n;Natrii dioctylsulfosuccinas;Tex-Wet 1001;Airrol ct-1;Doc Q Lace;Mackanate dos-70;Nikkol otp-75;Gemtex pa-70;Rapisol a 30;Triton gr-pg 70;Dioctyl sulfosuccinate sodium;Sodium dioctyl sulphosuccinate;Nissan rapisol a 30;Jamylene;Bis(2-ethylhexyl) sodium sulfosuccinate;Sodium 2-ethylhexylsulfosuccinate;Sodium bis(2-ethylhexyl) sulfosuccinate;HSDB 3065;Ins no.480;Monawet mo 65-150;2-Ethylhexyl sulfosuccinate sodium

Other docusate salts with medical use include those of calcium and potassium.
Docusate salts are also used as food additives, emulsifiers, dispersants, and wetting agents, among other uses.
Docusate is an organic sodium salt.
Docusate is on the World Health Organization's List of Essential Medicines.
In 2021, Docusate was the 133rd most commonly prescribed medication in the United States, with more than 4 million prescriptions.
In 2021, the combination with senna was the 275th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.
Docusate is a surfactant that is used in the formulation of aerosol products.
Docusate can be used as a matrix for the analytical determination of enzyme activities such as glutathione reductase and cytochrome p450, which are involved in the metabolism of xenobiotics. Docusate has been shown to have an optimum concentration of 0.1% and fluorescence probe with a pH range between 7-9.
The surfactant also shows ionotropic gelation properties at concentrations greater than 1%.

History
Docusate was patented in 1937 by Coleman R. Caryl and Alphons O. Jaeger for American Cyanamid, which commercialized it for many years as a detergent under the brand name Aerosol OT.
Docusate's use for the treatment of constipation was first proposed in 1955 by James L. Wilson and David G. Dickinson, and quickly popularized under the name Doxinate.

Structure and properties
The structural formula of the docusate anion is R−O−C(=O)−CH(SO−3)−CH2−C(=O)−O−R, where R is the 2-ethylhexyl group H3C−(CH2)3−C(−CH2−CH3)H−CH2−.
The conjugate acid can be described as the twofold carboxylate ester of sulfosuccinic acid with 2-ethylhexanol.
Docusate is a white, wax-like, plastic solid, with an odor suggestive of octyl alcohol.
Docusate starts to decompose at about 220 °C.

Solubility of Docusate in water is 14 g/L at 25 °C, increasing to 55 g/L at 70 °C.
Solubility is better in less polar solvents: 1:30 in ethanol, 1:1 in chloroform and diethylether, and practically unlimited in petroleum ether (25 °C).
Docusate also is highly soluble in glycerol, although this is a rather polar solvent.
Docusate is also highly soluble in xylene, oleic acid, acetone, diacetone alcohol, methanol, isopropanol, 2-butanol, methyl acetate, ethyl acetate, furfurol, and vegetable oils.
The ester groups are easily cleaved under basic conditions, but are stable against acids.

Synthesis
Docusate can be obtained by treating dioctyl maleate with sodium bisulfite.
The bisulfite anion adds to the double bond:

−CH=CH− + HSO−3 → −CH(−SO−3)−CH2−

Docusate Chemical Properties
Melting point: 173-179 °C(lit.)
Boiling point: 82.7°C
Density: 1.1
Vapor pressure: 0Pa at 25℃
Storage temp.: Inert atmosphere,Room Temperature
Solubility methanol: 0.1 M at 20 °C, clear, colorless
Form: Waxy Solid
Color: White
Specific Gravity: 1.005_PERCENT VOLATILE: 40
Water Solubility: 1.5 g/100 mL (25 ºC)
Sensitive: Hygroscopic
λmax λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05
Merck: 14,3401
BRN: 4117588
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: APSBXTVYXVQYAB-UHFFFAOYSA-M
LogP: 1.998 at 20℃
CAS DataBase Reference: 577-11-7(CAS DataBase Reference)
EPA Substance Registry System: Docusate (577-11-7)

Docusate is a white or almost white, waxlike, bitter tasting, plastic solid with a characteristic octanol-like odor.
Docusate is hygroscopic and usually available in the form of pellets, flakes, or rolls of tissuethin material.

Uses
Docusate is a mild surfactant used as a cleans ing agent.
Docusate, used for the treatment of constipation, acting as a laxative or stool softener.
Also used in the synthesis of electrospun fibres for tailored and controlled antibiotic drug release.
Forms reverse micelles in hydrocarbon solvents; Suitable for the solubilization of the major myelin transmembrane proteolipid
Docusate is a wetting and emulsifying agent that is slowly soluble in water, having a solubility of 1 g in 70 ml of water.
Docusate functions as a wetting agent in fumaric acid-containing powdered fruit drinks to help the acid dissolve in water.
Docusate is used as a stabilizing agent on gums at not more than 0.5% by weight of the gum.
Docusate is used as a flavor potentiator in canned milk where it improves and maintains the flavor of the sterilized milk during storage.
Docusate also functions as a processing aid in the manufacture of unrefined sugar.
Docusate is also termed sodium dioctylsulfosuccinate.

Medical use
The main medical use of docusate sodium is to treat constipation, acting as a laxative and stool softener.
In painful anorectal conditions such as hemorrhoid and anal fissures, Docusate can help avoid pain caused by straining during bowel movements.
When administered by mouth, a bowel movement often occurs in 1 to 3 days, while rectal use may be effective within 20 minutes.
Docusate is recommended as a stool softener for children.
However, its effectiveness for constipation is poorly supported by evidence.
Multiple studies have found docusate to be no more effective than a placebo for improving constipation.
Others have found it to be less useful for the treatment of chronic constipation than psyllium.
The medication may be given to people who are receiving opioid medication, although prolonged use may cause irritation of the gastrointestinal tract.

Other medical uses
Docusate, when used with ear syringing, may help with earwax removal, particularly in the case of impaction.
Docusate is also used as a lubricant in the production of tablets and as an emulsifier in topical preparations and other suspensions.

Precautions and contraindications
Docusate is approved and recommended as safe during pregnancy and breastfeeding.
Docusate is not recommended in people with appendicitis, acute abdomen, or ileus.
When taken by mouth Docusate should be ingested with plenty of water.

Side effects
Side effects are uncommon and typically mild, and may include stomach pain, abdominal cramps or diarrhea, Efficacy decreases with long-term use, and may cause poor bowel function.
Serious allergic reactions may occur with the drug.
The most severe side effect of docusate, although very rare, is rectal bleeding.

Food additive
Docusate has been approved by the US FDA as a "generally recognized as safe" (GRAS) additive.
Docusate is used in a variety of food products, as a surface active agent, stabilizer, thickener, wetting agent, processing aid, solubilizing agent, emulsifier, and dispersant.
The highest amount found in food products is 0.5% by weight, which include pasteurized cheese spreads, cream cheeses and salad dressings.
The FDA also approved Docusate's use as a wetting agent or solubilizer for flavoring agents in carbonated and non-carbonated drinks at levels up to 10 parts per million.

Toxicity
Ingestion may cause the side effects described above, such as diarrhea, intestinal bloating, and occasionally cramping pains.
Docusate is not known to be carcinogenic, mutagenic, or teratogenic.

Marine species
Docusate is of low toxicity for crustaceans such as the hermit crab Clibanarius erythropus and the shrimp Crangon crangon.
Toxicity for molluscs varies widely, with 48-hour LD50 found between 5 mg/L for the common limpet and 100 mg/L for the common periwinkle.
Various species of phytoplankton have an LD50 around 8 mg/L.

In a 2010 study, Docusate exhibited higher toxicity against bacteria (Vibrio fischeri, Anabaena sp.) and algae (Pseudokirchneriella subcapitata) than did a number of fluorinated surfactants (PFOS, PFOA, or PFBS).
Measuring bioluminescence inhibition of the bacteria and growth inhibition of the algae, the LD50 were in the range of 43–75 mg/L.
Combinations of the fluorinated compounds with Docusate showed mid to highly synergistic effects in most settings, meaning that such combinations are significantly more toxic than the individual substances.

Freshwater species
Docusate is highly toxic for rainbow trout with a median lethal concentration (LC50) of 0.56 mg/L after 48 hours for the pure substance.
Docusate is only slightly to moderately toxic for rainbow trout fingerlings, and slightly toxic for harlequin rasboras (LC50 27 mg/L of a 60% formulation after 48 hours).

Docusate (Dioctyl sulfosuccinate) is all-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries.
Docusate (Dioctyl sulfosuccinate) is a diester and an organosulfonic acid.


CAS Number: 10041-19-7
as salt: 577-11-7
E number: E480 (thickeners, ...)
Molecular Formula: C20H37O7S


Docusate (Dioctyl sulfosuccinate) does not appear to lessen symptoms associated with constipation such as abdominal cramps.
Docusate (Dioctyl sulfosuccinate) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation.
Docusate (Dioctyl sulfosuccinate) is all-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries.


Docusate (Dioctyl sulfosuccinate) has also been used in laxatives and as cerumenolytics.
Docusate (Dioctyl sulfosuccinate) is usually administered as either the calcium, potassium, or sodium salt.
Docusate (Dioctyl sulfosuccinate) is a diester and an organosulfonic acid.


Docusate (Dioctyl sulfosuccinate) is a stool softener indicated for the treatment of constipation.
Docusate (Dioctyl sulfosuccinate) acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.
Docusate (Dioctyl sulfosuccinate) can be orally or rectally administered.


Docusate (Dioctyl sulfosuccinate) is on the World Health Organization's List of Essential Medicines.
Docusate (Dioctyl sulfosuccinate) is a stool softener.
Docusate (Dioctyl sulfosuccinate) works by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.


Docusate (Dioctyl sulfosuccinate) is a stool softener that makes bowel movements softer and easier to pass.
Docusate (Dioctyl sulfosuccinate) is a medication used to treat and prevent constipation (dry or hard stools) in children who have undergone liver transplantation.


Docusate (Dioctyl sulfosuccinate) works by incorporating water and fat into your stool.
People taking this medication usually feel relief one to two days after the first dose, but three or four days may pass before Docusate (Dioctyl sulfosuccinate) is effective.


Docusate (Dioctyl sulfosuccinate) is a stool softener that makes bowel movements softer and easier to pass.
Docusate (Dioctyl sulfosuccinate) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 tonnes per annum.


Docusate (Dioctyl sulfosuccinate) is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS).
Docusate (Dioctyl sulfosuccinate) is on the World Health Organization's List of Essential Medicines.


Salts of this anion, especially docusate sodium, are widely used in medicine as laxatives and as stool softeners, by mouth or rectally.
In 2020, Docusate (Dioctyl sulfosuccinate) was the 163rd most commonly prescribed medication in the United States, with more than 3 million prescriptions.


Some studies claim that Docusate (Dioctyl sulfosuccinate) is not more effective than a placebo for improving constipation.
Other Docusate (Dioctyl sulfosuccinate) salts with medical use include those of calcium and potassium.
Docusate (Dioctyl sulfosuccinate) is recommended as a stool softener for children.
Docusate (Dioctyl sulfosuccinate) is a stool softener which makes bowel movements softer and easier to move.


Docusate (Dioctyl sulfosuccinate) is a laxative used to treat constipation (difficulty pooping).
Docusate (Dioctyl sulfosuccinate) helps soften your poop and makes your bowel movements easier.
Docusate (Dioctyl sulfosuccinate)'s helpful if you have difficulty going to the toilet because of dry poops or piles (haemorrhoids) or if you have a tear in the linen of your anus (an anal fissure).



USES and APPLICATIONS of DOCUSATE (DIOCTYL SULFOSUCCINATE):
Docusate (Dioctyl sulfosuccinate) is a stool softener used to treat occasional constipation and hard stools.
Docusate (Dioctyl sulfosuccinate) may also be used to empty bowels before surgery or other medical procedures.
Docusate (Dioctyl sulfosuccinate) works by increasing the water content of stools.


Docusate (Dioctyl sulfosuccinate) belongs to the class of laxatives, it works by increasing the amount of water that stools absorb in the intestines, making stools softer and easier to pass.
This is considered the first method used by doctors to prevent and treat constipation.


Docusate (Dioctyl sulfosuccinate) is often used when straining to have a bowel movement needs to be avoided (eg, after a heart attack or after surgery).
Docusate (Dioctyl sulfosuccinate) is a common medication for relieving constipation.


Docusate (Dioctyl sulfosuccinate) is a stool softener.
Docusate (Dioctyl sulfosuccinate) works by lowering the surface tension of the stool by allowing more water and fat to get mixed in the intestines, making it easy for the hard stool to pass.


Docusate (Dioctyl sulfosuccinate) also works by reducing water reabsorption and increasing fluid secretion in the small intestine.
After that, the Docusate (Dioctyl sulfosuccinate) gets absorbed into the blood and metabolized before it is excreted through the gallbladder.
Docusate (Dioctyl sulfosuccinate) is used to relieve occasional constipation (irregularity).


Docusate (Dioctyl sulfosuccinate) is used to relieve occasional constipation (irregularity).
Docusate (Dioctyl sulfosuccinate) is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


Docusate (Dioctyl sulfosuccinate) is used in the following products: coating products, fillers, putties, plasters, modelling clay, washing & cleaning products, adhesives and sealants, finger paints and fertilisers.
Other release to the environment of Docusate (Dioctyl sulfosuccinate) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


Other release to the environment of Docusate (Dioctyl sulfosuccinate) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


Release to the environment of Docusate (Dioctyl sulfosuccinate) can occur from industrial use: of articles where the substances are not intended to be released and where the conditions of use do not promote release.
Docusate (Dioctyl sulfosuccinate) can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), plastic (e.g. food packaging and storage, toys, mobile phones), wood (e.g. floors, furniture, toys) and leather (e.g. gloves, shoes, purses, furniture).


Docusate (Dioctyl sulfosuccinate) is used in the following products: washing & cleaning products and polishes and waxes.
Docusate (Dioctyl sulfosuccinate) is used in the following areas: mining, agriculture, forestry and fishing, formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.


Docusate (Dioctyl sulfosuccinate) is used for the manufacture of: chemicals, textile, leather or fur, plastic products and food products.
Other release to the environment of Docusate (Dioctyl sulfosuccinate) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


Docusate (Dioctyl sulfosuccinate) is used in the following products: metal working fluids, polymers, lubricants and greases, hydraulic fluids, plant protection products, pH regulators and water treatment products and textile treatment products and dyes.
Docusate (Dioctyl sulfosuccinate) has an industrial use resulting in manufacture of another substance (use of intermediates).


Release to the environment of Docusate (Dioctyl sulfosuccinate) can occur from industrial use: formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, as processing aid, for thermoplastic manufacture and formulation in materials.


Docusate (Dioctyl sulfosuccinate) is used in the following products: polymers, washing & cleaning products, textile treatment products and dyes, lubricants and greases, pH regulators and water treatment products, metal working fluids, leather treatment products and hydraulic fluids.
Docusate (Dioctyl sulfosuccinate) is used in the following areas: mining, agriculture, forestry and fishing, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and formulation of mixtures and/or re-packaging.


Docusate (Dioctyl sulfosuccinate) is used for the manufacture of: chemicals, textile, leather or fur, plastic products and food products.
Release to the environment of Docusate (Dioctyl sulfosuccinate) can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, formulation of mixtures and manufacturing of the substance.


Release to the environment of Docusate (Dioctyl sulfosuccinate) can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and for thermoplastic manufacture.


Docusate (Dioctyl sulfosuccinate) is commonly available as an over-the-counter laxative or stool softener.
Docusate (Dioctyl sulfosuccinate) is indicated when there is any constipation like hard stools or opioid-induced constipation.
Docusate (Dioctyl sulfosuccinate) is also effective in patients suffering from conditions like anal fissures and hemorrhoids that cause pain while trying to pass the stool.


However, multiple studies like this have found that Docusate (Dioctyl sulfosuccinate)is not as effective because a placebo given in its place showed the same results.
There are a few other uses of Docusate (Dioctyl sulfosuccinate), such as removing ear wax and making other tablets.


Docusate (Dioctyl sulfosuccinate), when used with ear syringing, may help with earwax removal, particularly in the case of impaction.
Docusate (Dioctyl sulfosuccinate) is being used to diagnose occasional constipation.
Some medicines and conditions may make constipation more likely.


Stool softeners, such as Docusate (Dioctyl sulfosuccinate), are always the first method used to prevent and treat this type of constipation.
Docusate (Dioctyl sulfosuccinate) is often used when straining to prevent bowel movements (e.g. after a heart attack or surgery).
Docusate (Dioctyl sulfosuccinate) is a stool softener.


This medication works by increasing the amount of water the stool absorbs in the gut and making the stool softer and easier to pass.
Docusate (Dioctyl sulfosuccinate) is also used as a lubricant in the production of tablets and as an emulsifier in topical preparations and other suspensions.


Docusate (Dioctyl sulfosuccinate) salts are also used as food additives, emulsifiers, dispersants, and wetting agents, among other uses.
Docusate (Dioctyl sulfosuccinate) is used to relieve constipation irregularity.


-Medical use of Docusate (Dioctyl sulfosuccinate):
*Constipation:
The main medical use of Docusate (Dioctyl sulfosuccinate) is to treat constipation, acting as a laxative and stool softener.
In painful anorectal conditions such as hemorrhoid and anal fissures, Docusate (Dioctyl sulfosuccinate) can help avoid pain caused by straining during bowel movements.



HOW DOES DOCUSATE (DIOCTYL SULFOSUCCINATE) WORK?
Docusate (Dioctyl sulfosuccinate) is used to treat occasional constipation.
Some medications and conditions can make constipation more likely.
Stool softeners such as Docusate (Dioctyl sulfosuccinate) are often the first method used for preventing and treating this type of constipation.
Docusate (Dioctyl sulfosuccinate) is often used when straining to have a bowel movement should be avoided (e.g., after a heart attack or surgery).



IS DOCUSATE (DIOCTYL SULFOSUCCINATE) SAFE IN PREGNANCY?
Yes, Docusate (Dioctyl sulfosuccinate) is completely safe in pregnancy and breastfeeding.
Docusate (Dioctyl sulfosuccinate) does not cause any harmful effects on the fetus.
In recommended doses, Docusate (Dioctyl sulfosuccinate) helps relieve constipation in pregnant women.



HISTORY of DOCUSATE (DIOCTYL SULFOSUCCINATE):
Docusate (Dioctyl sulfosuccinate) was patented in 1937 by Coleman R. Caryl and Alphons O. Jaeger for American Cyanamid, which commercialized it for many years as a detergent under the brand name Aerosol OT.
Docusate (Dioctyl sulfosuccinate)'s use for the treatment of constipation was first proposed in 1955 by James L. Wilson and David G. Dickinson and quickly popularized under the name Doxinate.



WHAT IS DOCUSATE (DIOCTYL SULFOSUCCINATE) AND WHAT IS IT USED FOR:
Docusate (Dioctyl sulfosuccinate) is a stool softening laxative available over-the-counter, used to treat constipation.
Docusate (Dioctyl sulfosuccinate) may be used to relieve constipation associated with opioid therapy, or in people who should avoid straining for a bowel movement, for instance, after surgery or a heart attack.
Use of Docusate (Dioctyl sulfosuccinate) may ease bowel movements and reduce pain in people with anorectal fissures and hemorrhoids.

Docusate (Dioctyl sulfosuccinate) may also be used (off-label) for softening of earwax (cerumen) to facilitate its removal.
Docusate (Dioctyl sulfosuccinate) softens the stool by reducing the surface tension of the oil-water interface in the stool, which increases the absorption of water and fat into the stool.

Studies indicate that Docusate (Dioctyl sulfosuccinate) also stimulates secretion of water, sodium, chloride and potassium and inhibits the absorption of bicarbonate and glucose in the jejunum portion of the small intestine, which allows the bowel contents to retain more fluid.
Docusate (Dioctyl sulfosuccinate) may be administered orally or rectally. Rectal administration takes effect within 15 minutes while it may take 12 to 72 hours for a bowel movement to occur after oral dosing.

Rectal administration has local effects, while oral Docusate (Dioctyl sulfosuccinate) is systemically absorbed and is metabolized by the liver and excreted in the feces.
Excessive use of stool softeners including Docusate (Dioctyl sulfosuccinate), can cause dependence on them for bowel movements.
Chronic constipation should be ideally managed with exercise and lifestyle modifications; Docusate (Dioctyl sulfosuccinate) should be used only for relief from occasional constipation or in specific conditions that require avoiding straining for a bowel movement.



PHYSICAL and CHEMICAL PROPERTIES of DOCUSATE (DIOCTYL SULFOSUCCINATE):
Physical state: Wax like
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 173 - 179 °C
Initial boiling point and boiling range: > 200 °C at 984 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: > 180 °C - Relative self-ignition temperature for solids
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility 8,17 g/l at 20 °C soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,146 g/cm3 at 27,4 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available

Oxidizing properties: The product has been shown not to be oxidizing.
Surface tension: 30,65 mN/m at 1g/l at 20 °C
Molecular Weight: 422.6 g/mol
XLogP3-AA: 5.1
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 18
Exact Mass: 422.23382472 g/mol
Monoisotopic Mass: 422.23382472 g/mol
Topological Polar Surface Area: 115Ų
Heavy Atom Count: 28
Formal Charge: 0
Complexity: 539
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 3
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular form: C20H38O7S
Appearance: NA
Mol. Weight: 422.58
Storage: 2-8°C Refrigerator



FIRST AID MEASURES of DOCUSATE (DIOCTYL SULFOSUCCINATE):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DOCUSATE (DIOCTYL SULFOSUCCINATE):
-Personal precautions, protective equipment and emergency procedures:
*Advice for non-emergency personnel:
Ensure adequate ventilation.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with suitable equipment.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of DOCUSATE (DIOCTYL SULFOSUCCINATE):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DOCUSATE (DIOCTYL SULFOSUCCINATE):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type ABEK-P
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DOCUSATE (DIOCTYL SULFOSUCCINATE):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of DOCUSATE (DIOCTYL SULFOSUCCINATE):
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
no information available



SYNONYMS:
Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate
Bis(2-ethylhexyl) sodium sulfosuccinate
dioctyl sodium sulfosuccinate
DSS
sodium dioctyl sulfosuccinate
sulfo-butanedioic acid 1,4-bis(2-ethylhexyl) ester
sodium salt sulfosuccinic acid 1,4-bis(2-ethylhexyl) ester sodium salt
DOCUSATE
Docusate hydrogen
10041-19-7
Spolion 8
DIOCTYL SULFOSUCCINATE
Dioctyl sulfosuccinic acid
1,4-Bis(2-ethylhexyl) 2-sulphosuccinate
1,4-Bis(2-ethylhexyl) sulfosuccinate
Diocto
EINECS 233-124-0
Doc-Q-Lace
Dioctylsulfosuccinsaeure
1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid
CHEBI:534
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
UNII-M7P27195AG
M7P27195AG
1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonic acid
Bis(2-ethylhexyl)succinat-2-sulfonsaeure
Di-beta-ethylhexyl sodium sulfo-succinate
1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure
Butanedionic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester
1,4-Bis((2-ethylhexyl)oxy)-1,4-dioxobutane-2-sulfonic acid
1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure [IUPAC]
C20H38O7S
DIOCTYL DISODIUM SULFOSUCCINATE
DIOCTYLSULFOSUCCINATE
Docusates
Dionex
Sulfosuccinic Acid bis(2-Ethylhexyl) Ester
DOCUSATE [VANDF]
bmse000720
D0X4FM
DOCUSATE [WHO-DD]
DOCUSATES [MART.]
SCHEMBL41958
CHEMBL1477036
DTXSID1044279
bis(2-ethylhexyl) sulfosuccinate
C20-H38-O7-S
LMFA07010721
Sulfosuccinic acid bis(2-ethylhexyl)
DB11089
LS-186430
C07874
EN300-20176424
Q27105309
Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
21954-86-9
1,4-Bis((2-ethylhexyl)oxy)-1,4-dioxobutane-2-sulfonic acid
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester
Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester (USP)

1,10-DECANEDICARBOXYLIC ACID; 1,12-DODECANEDIOIC ACID DDA; DDDA; DECAMETHYLENEDICARBOXYLIC ACID; DECANE-1,10-DICARBOXYLIC ACID; DICARBOXYLIC ACID C12; DODECANEDIOIC ACID; RARECHEM AL BO 0308; 1,10-decandicarboxylicacid; 1,10-dicarboxydecane; 1,12-Dodecandioic acid; 1,10-Decanedicarboxylicacid,99%; Dodecanedioic Acid (DDDA); DODECANEDIOCACID; DODECANEDIOIC; N-DODECANEDIOICACID 1,12-Dodecandisure; 1,12-Dodecanoic acid; DODECANE CAS NO:693-23-2

Dodecamethylcyclohexasiloxane is a clear, colorless liquid and is commonly used in various consumer and industrial products.
Dodecamethylcyclohexasiloxane, also known as D6 or simply 'siloxane,' is a chemical compound belonging to the class of organosilicon compounds.
Dodecamethylcyclohexasiloxane also has the added benefit of acting as a protective barrier to the skin, protecting the skin from moisture loss, allergens, and bacteria.

CAS Number: 540976
Molecular Formula: C12H36O6Si6
Molecular Weight: 444.92
EINECS Number: 2087628

Dodecamethylcyclohexasiloxane is a common ingredient in skincare and body care products, used to improve the texture of formulations.
While the texture is usually a sensory aspect of the product, in the case of Dodecamethylcyclohexasiloxane, it helps the product to be evenly distributed so the key ingredients can improve the skin.
Dodecamethylcyclohexasiloxane is a silicone-based compound frequently used in cosmetics and personal care products.

This clear, odorless liquid acts as a lightweight and volatile carrier ingredient that imparts a silky, non-greasy feel to skincare and haircare formulations.
Dodecamethylcyclohexasiloxane is known for its volatility, meaning it can easily evaporate into the air.
Dodecamethylcyclohexasiloxane enhances product spreadability, aids in quick absorption, and provides a smooth, matte finish.

Dodecamethylcyclohexasiloxane is a cyclic siloxane molecule composed of six silicon (Si) atoms alternately bonded to oxygen (O) atoms, forming a ring structure.
The chemical formula for Dodecamethylcyclohexasiloxane is typically represented as (SiO1.5)6.

Dodecamethylcyclohexasiloxane is often utilized alongside other silicones like cyclopentasiloxane to improve the overall texture and performance of cosmetic products.
Dodecamethylcyclohexasiloxane is a type of silicone.
Often, the terms 'silicone' and 'silicon' are mistakenly used interchangeably, when they are quite different.

Silicon is the 14th element on the periodic table and the second most abundant element in the earth’s crust after oxygen.
In contrast, silicones are always synthetically produced.
Dodecamethylcyclohexasiloxane is an organosilicon compound.

Dodecamethylcyclohexasiloxane, also known as D6, is an industrial chemical.
Dodecamethylcyclohexasiloxane is registered under the REACH Regulation and is manufactured in and/or imported to the European Economic Area, at ≥ 1,000 to < 10,000 tonnes per annum.

Silicones are synthetic polymers with a backbone composed of repeating units of siloxane, which is why silicones may also be referred to as polysiloxanes.
Siloxane is made up of elemental silicon and oxygen.
While cyclopentasiloxane is also commonly used, the choice between the two depends on the specific formulation and desired properties, making them valuable tools in cosmetic science.

The chemical formula of Dodecamethylcyclohexasiloxane is C12H36O6Si6.
Dodecamethylcyclohexasiloxane is a clear colorless liquid.
There is no known natural source of Dodecamethylcyclohexasiloxane.

Dodecamethylcyclohexasiloxane contains six repeating units of silicon (Si) and oxygen (O) atoms in a closed loop, giving it a 'cyclic' structure.
The cyclosiloxanes octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and Cyclohexasiloxane (D6) are cyclic volatile methyl siloxane (cVMS) substances with four, five, and six siloxane groups, respectively.

D4, D5, and Dodecamethylcyclohexasiloxane are the three cyclosiloxanes in commercial production, and their use has been proven safe for human health and the environment.
Dodecamethylcyclohexasiloxane is part of a family of small silicones called Cyclohexasiloxane.
Dodecamethylcyclohexasiloxane are part of the silicone family and are used in a similar way to dimethicone, which you may be familiar with.

Dodecamethylcyclohexasiloxane help smooth the texture of products, improve the appearance of scarring, increase the waterresistance abilities of formulations, and emulsify the product.
Dodecamethylcyclohexasiloxane are also better at delivering active ingredients to the skin as they are more volatile than larger silicones and slowly evaporate from the skin.

Dodecamethylcyclohexasiloxane are clear, odorless liquids utilized in skincare products to give your skincare a smooth texture that allows the product’s key ingredients to be delivered evenly to the skin.
The functional group R3SiO− (where the three Rs may be different) is called siloxy.
Cyclosiloxanes are basic members of the broad family of silicone materials.

All silicone materials share a common chemistry but each substance is different with regard to its properties and use.
When Dodecamethylcyclohexasiloxane disappear, they leave behind the formulation’s key ingredients.
Dodecamethylcyclohexasiloxane are also known as Cyclohexasiloxane, different names for the same class of molecules.

Dodecamethylcyclohexasiloxane, more commonly known as Cyclohexasiloxane, contains six repeating units of silicon (Si) and oxygen (O) atoms in a closed loop, giving it a cyclic structure.
The parent siloxanes include the oligomeric and polymeric hydrides with the formulae H(OSiH2)nOH and (OSiH2)n.
When used as an intermediate during the manufacturing process, virtually all Dodecamethylcyclohexasiloxane is consumed with only a tiny amount remaining in final products.

Dodecamethylcyclohexasiloxane’s structure forms a ring which makes it more volatile or less stable.
This instability allows Dodecamethylcyclohexasiloxane to evaporate when applied to your skin readily.
This characteristic makes Dodecamethylcyclohexasiloxane a great ingredient for improving the spreadability of products and ensuring they don’t remain sticky after application.

Dodecamethylcyclohexasiloxane gradually evaporates from the skin, leaving behind the other key components in the product to improve the appearance of the skin.
This action of evaporation makes it an excellent carrier ingredient.
Dodecamethylcyclohexasiloxane belonging to the class of cyclic volatile methylsiloxanes is identified as a potent environmental contaminant, most prominently found in biota, biosolid samples, soil, sediment samples, wastewaters, etc.

Dodecamethylcyclohexasiloxane can also be used as an ingredient in silicone mixtures used in cosmetic applications such as skin creams and deodorants, where D6 Siloxane may be labelled "cyclomethicone" or "Dodecamethylcyclohexasiloxane".
Dodecamethylcyclohexasiloxane are used as fragrance carriers or solvents in household products, personal care products, cleaning agents and as precursors in the manufacture of silicone polymers.

Siloxanes also include branched compounds, the defining feature of which is that each pair of silicon centres is separated by one oxygen atom.
The siloxane functional group forms the backbone of silicones, the premier example of which is polydimethylsiloxane.
A siloxane is a functional group in organosilicon chemistry with the Si−O−Si linkage.

Dodecamethylcyclohexasiloxane, also known as Cyclohexasiloxane or D6, belongs to a group of cyclic volatile methylsiloxanes (cVMS) with relatively low molecular weight (< 600 g/mol) and high vapor pressure.
Dodecamethylcyclohexasiloxane is synthetically produced through a chemical process known as cyclotetramerization, where the precursor compound is subjected to high temperatures and catalysts to form the cyclic structure.

A lightfeeling, volatile (meaning it does not absorb into the skin but evaporates from it) silicone that gives skin a unique, silky and nongreasy feel.
Dodecamethylcyclohexasiloxane helps give skin care products a silkysmooth, spreadable consistency, so key ingredients can be delivered evenly to skin.
Dodecamethylcyclohexasiloxane is also known to promote aesthetically pleasing finishes that don’t feel sticky, tacky or greasy after application.

In hair care, Dodecamethylcyclohexasiloxane is used to add shine and reduce frizz.
Dodecamethylcyclohexasiloxane has excellent spreading properties and leaves no oily residue or buildup.
Dodecamethylcyclohexasiloxane is one of several forms of synthetic, cyclic (meaning the molecule is circular rather than straight or crosslinked) silicone used in cosmetic formulas to improve texture and enhance skin’s hydration.

Dodecamethylcyclohexasiloxane is used by consumers, by professional workers (widespread uses), in formulation or repacking, at industrial sites, and in manufacturing.
Dodecamethylcyclohexasiloxane is used in the following products: washing & cleaning products, polishes and waxes, and cosmetics and personal care products.

Other release to the environment of Dodecamethylcyclohexasiloxane is likely to occur from: indoor use as a processing aid and outdoor use as a processing aid.
This process involves the controlled arrangement of silicon and oxygen atoms to create the Dodecamethylcyclohexasiloxane molecule (D6).
The resulting clear, volatile liquid is then purified for use in cosmetics.

Dodecamethylcyclohexasiloxane can also be used as an ingredient in silicone mixtures used in cosmetic applications such as skin creams and deodorants.
When Dodecamethylcyclohexasiloxane is used as an intermediate during the manufacturing process, virtually all Dodecamethylcyclohexasiloxane is consumed with only a tiny amount remaining in final products.
Dodecamethylcyclohexasiloxane imparts several benefits in personal care formulations, such as silkiness for conditioners, extra volume in lip glosses, and easy application in deodorants.

This product has a Dodecamethylcyclohexasiloxane content of 94%.
Cyclosiloxanes are used in the manufacture of silicones, in combination or alone in personal care products, and as carriers, lubricants, and solvents in a variety of commercial applications.
Their use in cosmetics is one of their most important applications.

D5 and Dodecamethylcyclohexasiloxane are commonly used in cosmetics as emollients, hair and skin conditioning ingredients, and solvents.
The ingredients can be used in hair conditioning products where the product is washed off when used or in skincare products, personal deodorants, and color cosmetics where the product is left on the skin.

Dodecamethylcyclohexasiloxane can also be used as an ingredient in silicone mixtures used in cosmetic applications such as skin creams and sunscreen, where Dodecamethylcyclohexasiloxane may be labeled 'cyclomethicone' or 'Cyclohexasiloxane'.
Dodecamethylcyclohexasiloxane is used in cosmetic and personal care products.

Dodecamethylcyclohexasiloxane is Used in dermal exposure.
Dodecamethylcyclohexasiloxane is used in cosmetic and personal care products.
Dodecamethylcyclohexasiloxane is used in personal care products such as hair/skin care products, antiperspirants and deodorants.

Biomedical uses of silicones include medical devices, blood-handling equipment, as a blood defoaming agent, as protective barriers, lubricants, and as surface treatment of wound dressings.
Silicone fluids containing Dodecamethylcyclohexasiloxane have also been approved as active and nonactive ingredients in pharmaceuticals in Canada, the most common use being in antiflatulence drugs.

Dodecamethylcyclohexasiloxane is used in dermal exposure and inhalation toxicity study.
The most important worldwide use of Dodecamethylcyclohexasiloxane is as an ingredient in the formulation of personal care products and as an intermediate in the production of polydimethylsiloxanes (PDMS) silicone polymers.

The predominant use of Dodecamethylcyclohexasiloxane worldwide and in Canada is in blending and formulating consumer products and manufacturing silicone polymers.
Dodecamethylcyclohexasiloxane is a silicone-based emollient.
A cyclic volatile methylsiloxane (cVMS) used in cosmetic and personal care products, Dodecamethylcyclohexasiloxane can be used in dermal exposure and inhalation toxicity study.

Dodecamethylcyclohexasiloxanes are used as fragrance carriers or solvents in household products, personal care products, cleaning agents, and as precursors in the manufacture of silicone polymers.
Dodecamethylcyclohexasiloxane is used in the following products: cosmetics and personal care products, polishes and waxes, washing & cleaning products, and semiconductors.

Dodecamethylcyclohexasiloxane is also used in industrial processes (as a defoamer, surfactant in certain pesticide products); in lubricants, cleaning products, sealants, adhesives, waxes, polishes, and coatings.
Siloxanes are manmade and have many commercial and industrial applications because of the compounds’ hydrophobicity, low thermal conductivity, and high flexibility.

Dodecamethylcyclohexasiloxane is an odorless, colorless liquid mostly used as an intermediate or basic raw material in the production silicone rubbers, gels, and resins.
As a raw material, Dodecamethylcyclohexasiloxane is a colourless liquid.
Dodecamethylcyclohexasiloxane is described as a lightweight carrier ingredient since it evaporates from skin, leaving behind the formula’s key ingredients to work effectively.

This ingredient has been deemed safe by the Cosmetic Ingredient Review Expert Panel (their report looked at products using between 0.000448% Dodecamethylcyclohexasiloxane).
Dodecamethylcyclohexasiloxane prevents the product from catching on dry skin patches and evens skin tone by gliding over pores and wrinkles.

Dodecamethylcyclohexasiloxane ensures that all areas of the skin are receiving the key ingredients in your product.
Dodecamethylcyclohexasiloxane, as a silicone, improves the feel, appearance, and performance of skincare and cosmetic formulations.
Dodecamethylcyclohexasiloxane is a multifunctional ingredient in skincare and cosmetic formulations.

Dodecamethylcyclohexasiloxane helps to produce an even, smooth formulation that allows the product to spread evenly over the skin.
Dodecamethylcyclohexasiloxane can also be used as an ingredient in silicone mixtures used in cosmetic applications such as skin creams and deodorants, where D6 Siloxane may be labeled Dodecamethylcyclohexasiloxane.

In personal care products, cyclosiloxanes act as 'carriers,' allowing products to spread smoothly and easily and providing a silky feel during application.
Dodecamethylcyclohexasiloxane is an odorless, colorless liquid mostly used as an intermediate or basic raw material in the production silicone rubbers, gels, and resins.

Dodecamethylcyclohexasiloxane is used in the following areas: health services and formulation of mixtures and/or repackaging.
Cyclomethicone (mixture) and the specific chain length cyclic siloxanes (n = 47) reviewed in this safety assessment are cyclic dimethyl polysiloxane compounds.
These ingredients have the skin/hair conditioning agent function in common.

Melting point: 3°C
Boiling point: 245 °C
Density: 0,959 g/cm3
vapor pressure: 4.7Pa at 25℃
refractive index: 1.4015
Flash point: >76°C
storage temp.: 28°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: liquid
color: Colourless
Specific Gravity: 0.9672
Odor: at 100.00?%. odorless
Viscosity: 5.6mm2/s
Water Solubility: 5.1μg/L at 23℃
Hydrolytic Sensitivity 1: no significant reaction with aqueous systems
Merck: 14,3403
Stability: Hygroscopic
LogP: 8.87 at 23.6℃

Dodecamethylcyclohexasiloxane is a clear, odorless liquid at room temperature.
Silicone compounds D4 (cyclotetrasiloxane), D5 (cyclopentasiloxane), and Dodecamethylcyclohexasiloxane are often found in personal care products and flow into the environment along with wastewater.
Dodecamethylcyclohexasiloxane is found or used in the manufacture of a wide variety of products.

These compounds are cyclic methyl siloxane substances containing four, five, and six siloxane groups, respectively, and they have a mild and refreshing effect in cosmetic products.
Dodecamethylcyclohexasiloxane is a volatile substance due to its ringshaped structure.
This allows it to evaporate from the skin, leaving behind the product’s ‘active’ ingredients to work their magic.

Synthetic ingredients are usually safer than their plant or animalderived counterparts as they contain fewer impurities and are less complex, making them less likely to irritate.
They are also better for the environment as it doesn’t deplete a natural resource.
Dodecamethylcyclohexasiloxane, along with other Dodecamethylcyclohexasiloxane, were analyzed in a study published in Skin Pharmacology and Physiology.

Dodecamethylcyclohexasiloxane also helps to reduce the heaviness of other silicone ingredients.
Synthetic ingredients often have a bad reputation in the skincare world as they are considered not natural.
This plays into the idea that natural is always better, which isn’t always true.

They are usually present in cosmetic products (makeup, cream, deodorant, etc.) and more widely in certain cleaning products or paints.
Organosiloxanes are widely used in personal care products because they provide desirable properties in cosmetic products.

These compounds are octamethylcyclotetrasiloxane (D4), decamethylcyclotetrasiloxane (D5), and Cyclohexasiloxane (D6).
They are also important source materials for certain silicones and are often found as residues in finished products.
Basic members of the broad family of silicone materials, all cyclotetrasiloxane (D4), cyclopentasiloxane (D5), and Dodecamethylcyclohexasiloxane are volatile oils with a cyclic chemical structure and various properties.

Cyclopentasiloxane is a silicone regularly used in cosmetic products.
Dodecamethylcyclohexasiloxane’s commonly found in medical implants, sealants, lubricants, and windshield coatings.
Dodecamethylcyclohexasiloxane is colorless, odorless, nongreasy, and waterthin.

Dodecamethylcyclohexasiloxane doesn’t get absorbed into the skin. Rather, it evaporates quickly away from it.
This property makes it a useful ingredient in cosmetic products that need to dry quickly, like antiperspirants and hair sprays.

Dodecamethylcyclohexasiloxane also has lubricating properties.
This gives a slippery and silky feeling when applied to the skin and hair and allows the product to spread more easily.
They are widely used because of the smooth and refreshing feeling they create.

Uses
Dodecamethylcyclohexasiloxane used in cosmetic and personal care products.
Dodecamethylcyclohexasiloxane can improve the texture and spreadability of creams and lotions, providing a smooth and silky feel to the skin and hair.
Dodecamethylcyclohexasiloxane is used as a lubricant and anti-foaming agent in industrial processes and machinery.

Dodecamethylcyclohexasiloxane also provides heat protection, making it beneficial for use with styling tools, such as flat irons and hairdryers, while minimizing damage and maintaining a sleek, polished appearance
Dodecamethylcyclohexasiloxane is found or used in the manufacture of a wide variety of products.
The predominant use of Dodecamethylcyclohexasiloxane worldwide and in Canada is in blending and formulating consumer products and manufacturing silicone polymers.

Dodecamethylcyclohexasiloxane may be used in certain pharmaceutical formulations and drug delivery systems.
Dodecamethylcyclohexasiloxane serves as a precursor in the synthesis of more complex silicone compounds and polymers, which have a wide range of industrial applications.
Dodecamethylcyclohexasiloxane is also used in industrial processes (as a defoamer, surfactant in certain pesticide products); in lubricants, cleaning products, sealants, adhesives, waxes, polishes and coatings.

Dodecamethylcyclohexasiloxane is not currently manufactured in Canada; however, it is imported into Canada.
Dodecamethylcyclohexasiloxane is used in the following products: polymers, washing & cleaning products, laboratory chemicals and polishes and waxes.
Dodecamethylcyclohexasiloxane can be used as a solvent in chemical reactions, especially those involving silicon-based compounds.

Dodecamethylcyclohexasiloxane is used in personal care products such as hair/skin care products, antiperspirants and deodorants.
Biomedical uses of silicones include medical devices, bloodhandling equipment, as a blood defoaming agent, as protective barriers, lubricants and as surface treatment of wound dressings.
Silicone fluids containing D6 have also been approved as active and nonactive ingredients in pharmaceuticals in Canada, the most common use being in antiflatulence drugs.

Dodecamethylcyclohexasiloxane serves as an excellent carrier for other active ingredients in a formulation, aiding in their penetration into the skin.
Its lightweight and noncomedogenic nature makes it ideal for moisturizers, serums, and sunscreens, providing a silky, smooth texture without clogging pores.
By creating a breathable barrier on the skin's surface, Dodecamethylcyclohexasiloxane helps in reducing water loss, enhancing hydration, and promoting a soft, supple complexion.

Dodecamethylcyclohexasiloxane contributes to smoother and more manageable hair.
Dodecamethylcyclohexasiloxane is commonly found in hair serums and conditioners, where it helps detangle and reduce frizz, resulting in silky, lustrous locks.
Dodecamethylcyclohexasiloxane has an industrial use resulting in manufacture of another substance (use of intermediates).

Dodecamethylcyclohexasiloxane is used in the following areas: scientific research and development.
Dodecamethylcyclohexasiloxane is used for the manufacture of: chemicals.
Release to the environment of Dodecamethylcyclohexasiloxane can occur from industrial use: for thermoplastic manufacture, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Due to its low viscosity, it spreads easily through the hair without leaving a heavy or greasy residue.
Dodecamethylcyclohexasiloxane can be used in the production of silicone-based polymers, sealants, and coatings due to its ability to crosslink and provide flexibility and resistance to heat and moisture.
Dodecamethylcyclohexasiloxane is used in dermal exposure and inhalation toxicity study.

Dodecamethylcyclohexasiloxane can be used in dermal exposure and inhalation toxicity study.
The compound is classified as a Cyclomethicone.
Such fluids are commonly used in cosmetics, such as deodorants, sunblocks, hair sprays, and skin care products.

Dodecamethylcyclohexasiloxane is also used as part of silicone-based personal lubricants.
Dodecamethylcyclohexasiloxane is considered an emollient.
In Canada, among the volume used in consumer products, approximately 70% were for antiperspirants and 20% for hair care products.

Dodecamethylcyclohexasiloxane is becoming more common in hair conditioners, as it makes the hair easier to brush without breakage.
10,000–100,000 tonnes per year of D5 is manufactured and/or imported in the European Economic Area.
Atmospheric emissions of Dodecamethylcyclohexasiloxane in the Northern Hemisphere were estimated to be 30,000 tonnes per year.

Such fluids are commonly used in cosmetics, such as deodorants, sunblocks, hair sprays and skin care products.
Dodecamethylcyclohexasiloxane is becoming more common in hair conditioners, as it makes the hair easier to brush without breakage.

Dodecamethylcyclohexasiloxane is also used as part of siliconebased personal lubricants. D5 is considered an emollient.
Dodecamethylcyclohexasiloxane is commonly used in cosmetics, skincare products, and hair care products as a lightweight, volatile silicone.

Safety Profile:
Dodecamethylcyclohexasiloxane is known for its relatively high persistence in the environment, especially in water bodies.
Dodecamethylcyclohexasiloxane can resist degradation, which means it may accumulate over time in aquatic ecosystems.

Dodecamethylcyclohexasiloxane may bioaccumulate in certain aquatic organisms, which means it can build up in the tissues of organisms over time.
Studies have indicated that Dodecamethylcyclohexasiloxane may have adverse effects on aquatic organisms, particularly in high concentrations.
These effects can include toxicity to aquatic life.

Dodecamethylcyclohexasiloxane is classified as a volatile organic compound (VOC) because of its volatility.
VOCs can contribute to air pollution when they evaporate into the atmosphere.

Synonyms
Dodecamethylcyclohexasiloxane
540976
Dodecamethylcyclohexasiloxane, dodecamethyl
Cyclomethicone 6
2,2,4,4,6,6,8,8,10,10,12,12dodecamethyl1,3,5,7,9,11hexaoxa2,4,6,8,10,12hexasilacyclododecane
XHK3U310BA
2,2,4,4,6,6,8,8,10,10,12,12Dodecamethylcyclohexasiloxane
EINECS 2087628
UNIIXHK3U310BA
HSDB 7723
EC 2087628
dodecamethyl Dodecamethylcyclohexasiloxane
SCHEMBL93785
XIAMETER PMX0246
Dodecamethylcyclohexasiloxane [INCI]
DTXSID6027183
IUMSDRXLFWAGNTUHFFFAOYSA
CHEBI:191103
IUMSDRXLFWAGNTUHFFFAOYSAN
CYCLOMETHICONE 6 [USPRS]
MFCD00144215
AKOS015839990
FS5671
Dodecamethylcyclohexasiloxane [MI]
Dodecamethylcyclohexasiloxane [HSDB]
D2040
Dodecamethylcyclohexasiloxane [WHODD]
FT0625566
S08515
T71035
Dodecamethylcyclohexasiloxane, analytical standard
A914553
Q27293843
2,2,4,4,6,6,8,8,10,10,12,12Dodecamethylcyclohexasiloxane #
Dodecamethylcyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12dodecamethyl
2,2,4,4,6,6,8,8,10,10,12,12Dodecamethylcyclohexasiloxane, 95%
2,2,4,4,6,6,8,8,10,10,12,12Dodecamethylcyclohexasiloxane, AldrichCPR
Cyclomethicone 6, United States Pharmacopeia (USP) Reference Standard
2,2,4,4,6,6,8,8,10,10,12,12dodecamethyl1,3,5,7,9,11hexaoxa2,4,6,8,10,12hexa
D6

Dodecane is a secondary metabolite.
Dodecane belongs to the class of organic compounds known as alkanes.


CAS Number： 112-40-3
EC Number： 203-967-9
MDL number: MFCD00008969
Structural Formula: CH3(CH2)10CH3
Chemical formula: C12H26



SYNONYMS:
Dodecane, Adakane 12, Ba 51-090453, C12-n-Alkane, Cactus Normal Paraffin N 12D, NSC 8714, Parafol 12-97, Parafol C12-97, n-Dodecane
n-dodecane, dihexyl, bihexyl, adakane 12, n-dodecan, n-dodecan german, duodecane, alkanes, c10-14, undecane, methyl, ccris 661, N-DODECANE, Dodecan, n-dodecan, DUODECANE, ADAKANE 12, Twelve alkyl, n-Dodecane min, BIHEXYL, DIHEXYL, odecane, Ba 51-090453, ba51-090453, CH3(CH2)10CH3, dodecanenormal, n-dodecan, n-Dodecane min, n-Dodecane, Adakane 12, Ba 51-090453, CH3(CH2)10CH3, Bihexyl, Dihexyl, Duodecane, NSC 8714, n-Dodecane, 112-40-3, Dihexyl, Bihexyl, Adakane 12, 93685-81-5, N-Dodecan, Duodecane, Ba 51-090453, NSC 8714, CCRIS 661, dodecan, Dodekan, HSDB 5133, EINECS 203-967-9, UNII-11A386X1QH, BRN 1697175, DTXSID0026913, CHEBI:28817, 11A386X1QH, NSC-8714, DTXCID906913, EC 203-967-9, 4-01-00-00498 (Beilstein Handbook Reference), 93924-07-3, Undecane, methyl-, n-Dodecan [German], CH3-(CH2)10-CH3, CH3-[CH2]10-CH3, Hydrocarbons, C4,1,3-butadiene-free, polymd., triisobutylene fraction, hydrogenated, 129813-67-8, D12, normal dodecane, Normal Paraffin M, EINECS 297-629-8, EINECS 300-199-7, MFCD00008969, Norpar 13, Dodecane, 99%, Alkane C(12), 1-DODECANE, DODECANE [HSDB], DODECANE [INCI], C12-N-ALKANE, EC 300-199-7, Dodecane(mixture of isomers), Dodecane, analytical standard, CHEMBL30959, Density Standard 749 kg/m3, Dodecane, anhydrous, >=99%, WLN: 12H, CH3(CH2)10CH3, NSC8714, Tox21_303615, Dodecane, ReagentPlus(R), >=99%, LMFA11000004, STL280320, Dodecane, technical, >=90% (GC), AKOS015904160, NCGC00166012-01, NCGC00257481-01, CAS-112-40-3, DA-16704, LS-14163, CS-0152244, D0968, NS00009666, D5580 n-Dodecane, 1.5% w/w in Isooctane, C08374, Q150744, 1310FACD-F2BF-4FD7-BC20-B21DF06EDE79, J-002767, Dodecane, certified reference material, TraceCERT(R), F0001-0259, Density Standard 749 kg/m3, H&D Fitzgerald Ltd. Quality, InChI=1/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H, Adakane 12, Bihexyl, CH3-[CH2]10-CH3, Dihexyl, Dodecane, Dodekan, Duodecane, N-Dodecane, Adakane 12, BIHEXYL, Ba 51-090453, CH3(CH2)10CH3, Dihexyl, Duodecane, NSC 8714, n-Dodecane



Dodecane is colourless liquid.
Dodecane, also known as bihexyl or CH3-[CH2]10-CH3, belongs to the class of organic compounds known as alkanes.
These are acyclic branched or unbranched hydrocarbons having the general formula CnH2n+2, and consist entirely of hydrogen atoms and saturated carbon atoms.


Dodecane is a hydrocarbon lipid molecule that is very hydrophobic molecule, practically insoluble in water, and relatively neutral.
Dodecane is found in higher concentrations in black walnuts and butter and lower amounts in lamb, cocoa, dill, wild strawberry, peas, tea and papaya.
Dodecane was detected in garden tomatoes.


Dodecane belongs to the class of organic compounds known as alkanes.
These are acyclic branched or unbranched hydrocarbons having the general formula CnH2n+2 , and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.


Dodecane, also known as bihexyl or CH3-[CH2]10-CH3, belongs to the class of organic compounds known as alkanes.
These are acyclic branched or unbranched hydrocarbons having the general formula CnH2n+2 , and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.


Thus, Dodecane is considered to be a hydrocarbon.
Dodecane is an alkane tasting compound.
Dodecane is found, on average, in the highest concentration within black walnuts (Juglans nigra).


Dodecane has also been detected, but not quantified in, several different foods, such as soy beans (Glycine max), carrots (Daucus carota ssp. sativus), papayas (Carica papaya), mung beans (Vigna radiata), and sweet cherries (Prunus avium).
This could make Dodecane a potential biomarker for the consumption of these foods.


Dodecane is a secondary metabolite.
Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules.
In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites.


Dodecane is a premium pharmaceutical grade compound extensively utilized across various industries such as pharmaceuticals, cosmetics, and chemicals.
Featuring molecular identity as C12H26 and impurity limit of ≥ 99.5%, Dodecane is colorless with a distinctive odor.
Dodecane’s infused in R&D processes for chromatography and spectrometry applications.


Dodecane is also known as duodecane or dihexyl.
Dodecane is a liquid alkane hydrocarbon and an oily liquid.
Dodecane is considered non-irritating and safe as used in cosmetics.


Dodecane is a hydrocarbon ingredient, meaning it’s composed of the elements carbon and hydrogen.
Dodecane belongs to the alkane class, a group of saturated, chemically inert emollients that help prevent water loss from skin and lend a supple texture to skin’s surface.


Of particular note is that Dodecane has very light, nearly weightless feel despite its emollient nature.
Dodecane may be derived from plants or made synthetically (Paula’s Choice uses the former).
Dodecane’s supplied as a clear, free-flowing liquid.


Dodecane (also known as dihexyl, bihexyl, adakane 12, or duodecane) is an oily liquid n-alkane hydrocarbon with the chemical formula C12H26 (which has 355 isomers).
Dodecane is a clear colorless liquid.


Dodecane is a straight-chain alkane with 12 carbon atoms.
Dodecane has been isolated from the essential oils of various plants including Zingiber officinale (ginger).
Dodecane has a role as a plant metabolite.


Dodecane is a natural product found in Camellia sinensis, Aristolochia triangularis, and other organisms with data available.
Dodecane, also known as n-dodecane or dodecyl hydrocarbon, is an alkane hydrocarbon with the chemical formula C12H26.
Dodecane exists as a colorless and flammable liquid with a subtle odor.


Notably, Dodecane is a common constituent of gasoline and finds utility in diverse industrial processes.
However, it is important to note that dodecane, classified as a volatile organic compound (VOC).
The versatility of dodecane has led to its utilization in numerous scientific research applications.


For instance, Dodecane serves as a valuable model compound in the exploration of thermodynamic and kinetic properties of hydrocarbons.
Additionally, Dodecane finds utility as a solvent in studies that investigate the physical properties of organic compounds.
Furthermore, Dodecane has been extensively employed to examine the structure, reactivity, and properties of organic molecules.


Dodecane is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Dodecane is hygroscopic.


Dodecane is incompatible with strong oxidizing agents.
Dodecane is a liquid alkane hydrocarbon that is found in black walnut that has 355 isomers.
Dodecane is an oily liquid of the paraffin series.


Dodecane is a colorless liquid that has a boiling point of 421.3° F at 760 mm Hg and a melting point of 14.7° F.
Dodecane is very soluble in ethyl ether, ethyl alcohol, carbon tetrachloride, and chloroform.
Dodecane is stable under recommended storage conditions.


Dodecane is a liquid alkane hydrocarbon with the chemical formula CH3(CH2)10CH3 (or C12H26).
Dodecane has 12 carbon atoms and 26 hydrogen atoms.
Dodecane has more isomers than the proceeding undecane.


Dodecane has 355 isomers.
Dodecane is clear, colorless liquid with a mild aliphatic hydrocarbon odor.
Dodecane is a straight-chain alkane with 12 carbon atoms.


Dodecane has been form the essential oils of various plants including Zingiber officinale (ginger).
Dodecane is also known as duodecane or dihexyl.
Dodecane is a liquid alkane hydrocarbon that is oily.


Dodecane has been used as a distillation chaser, a solvent and a scintillator component.
Dodecane denotes that this chemical is the highest quality commercially available and that the American Chemical Society has not officially set any specifications for this material.


Dodecane (also known as dihexyl, bihexyl, adakane 12 or duodecane) is a liquid alkane hydrocarbon with the chemical formula CH3(CH2)10CH3 (or C12H26), an oily liquid of the paraffin series.
Dodecane has 355 isomers.


Dodecane is a hydrocarbon that is used in the production of plastics and lubricants.
Dodecane can be found in a variety of products such as chewing gum, paints, waxes, and insecticides.
Dodecane exists as an oil at room temperature.


Dodecane has a high affinity for water vapor and will form hydrogen bonds with the molecule.
Hydroxyl ions can also bind to this substance, which causes Dodecane to expand when heated and become less dense when cooled.
The transport properties of Dodecane are dependent on its size and shape.


This hydrocarbon has a hydrophobic effect which enables it to be used as a catalyst in reactions involving acid complexes or cationic surfactants.
Kinetic studies have shown that Dodecane has microbial infection prevention properties against microorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cere



USES and APPLICATIONS of DODECANE:
Dodecane has been used as a distillation chaser, a solvent and a scintillator component.
Dodecane may be used as an inorganic diluent to form an organic phase along with decanol as an active diluent and tri-n-octylamine as an extractant.
Dodecane may be used for the extraction of lactic acid from aqueous solutions.


Dodecane is used as a solvent (inks and degreasing) and in chemical research and production.
Dodecane is used in paper processing.
Dodecane has a wide usage range in cosmetics, from 1–75% depending on desired aesthetics and attributes.


For example, much higher levels are used in hair care serums as a replacement for one or more silicones.
Dodecane is used for the production of dodecanedioic acid, linear alcohols, and halogenated alkanes, used as the main raw material oil for daily chemical products, etc


Dodecane is used as a standard substance for organic synthesis intermediates, solvents, and chromatographic analysis.
Dodecane is used gas chromatography analysis standards.
Dodecane is used organic synthesis.


For the production of C12 dibasic acid, linear alcohol and haloalkane, Dodecane is mainly used as the raw oil of cosmetic products.
Dodecane is used as a solvent, distillation chaser, and scintillator component.
Dodecane is used as a diluent for tributyl phosphate (TBP) in nuclear reprocessing plants.


Dodecane is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Dodecane is used in the following products: lubricants and greases, adhesives and sealants, polishes and waxes, coating products, cosmetics and personal care products, fuels, perfumes and fragrances, anti-freeze products, fillers, putties, plasters, modelling clay and inks and toners.


Other release to the environment of Dodecane is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Dodecane is used in the following products: laboratory chemicals, pH regulators and water treatment products, adhesives and sealants, coating products, metal surface treatment products, heat transfer fluids, hydraulic fluids, metal working fluids and washing & cleaning products.
Dodecane is used in the following areas: health services and scientific research and development.


Other release to the environment of Dodecane is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Release to the environment of Dodecane can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, formulation in materials, as processing aid, manufacturing of the substance, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.


Dodecane is used in the following products: laboratory chemicals, coating products, metal working fluids, adhesives and sealants, metal surface treatment products, heat transfer fluids, hydraulic fluids, washing & cleaning products and pH regulators and water treatment products.
Dodecane is used in the following products: cosmetics and personal care products and perfumes and fragrances.


Dodecane is used in the following areas: formulation of mixtures and/or re-packaging, health services and scientific research and development.
Release to the environment of Dodecane can occur from industrial use: in processing aids at industrial sites, manufacturing of the substance, as processing aid, of substances in closed systems with minimal release, formulation of mixtures and formulation in materials.


Release to the environment of Dodecane can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as processing aid, formulation in materials, formulation of mixtures, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.


Dodecane may be utilized as an inorganic diluent to form an organic phase together with tri-n-octylamine as an extractant and decanol as an active diluent.
Notably, this system can also be employed in the extraction of lactic acid from aqueous solutions.
Food Additives: Dodecane can be used as a flavoring agent in food processing


Dodecane is used for the manufacture of: chemicals.
Consumer Uses: Dodecane is used as an adhesive and sealants.
Dodecane is used as a solvent, distillation chaser, scintillator component.


Moreover Dodecane is used as a diluent for tributyl phosphate (TBP) in plants reprocessing.
Dodecane is used as a solvent and a distillation chaser.
Dodecane finds application as a diluent for tributyl phosphate (TBP) in reprocessing plants and as a possible surrogate for kerosene-based fuels in jet.


Dodecane is an active component of scintillator as well as used in lubricants and greases.
Dodecane is used as a solvent and a distillation chaser.
Dodecane finds application as a diluent for tributyl phosphate (TBP) in reprocessing plants and as a possible surrogate for kerosene-based fuels in jet.


Dodecane is an active component of scintillator as well as used in lubricants and greases.
Dodecane is a component of gasoline and is used as solvent, in organic synthesis, in jet fuel research, as a distillation chaser, and in the rubber and paper processing industries.


Dodecane is used solvent; jet fuel research; rubber industry; manufacturing paraffin products; paper processing industry; standardized hydrocarbon; distillation chaser; gasoline component; organic synthesis.
Dodecane is used as a solvent and a distillation chaser.


Dodecane finds application as a diluent for tributyl phosphate (TBP) in reprocessing plants and as a possible surrogate for kerosene-based fuels in jet.
Dodecane is an active component of scintillator as well as used in lubricants and greases.


-Industrial Uses:
Dodecane has been used in the aviation industry as an alternate for kerosene-based fuels such as Jet-A.
Dodecane has also been used as a lubricant and additive to lubricants.



COMBUSTION REACTION OF DODECANE:
The combustion reaction of Dodecane is as follows:
C12H26(l) + 18.5 O2(g) → 12 CO2(g) + 13 H2O(g)
ΔH° = −7513 kJ
One litre of fuel needs about 15 kg of air to burn (2.6 kg of oxygen), and generates 2.3 kg (or 1.2 m3) of CO2 upon complete combustion.

Jet fuel surrogate:
In recent years, Dodecane has garnered attention as a possible surrogate for kerosene-based fuels such as Jet-A, S-8, and other conventional aviation fuels.
Dodecane is considered a second-generation fuel surrogate designed to emulate the laminar flame speed, largely supplanting n-decane, primarily due to its higher molecular mass and lower hydrogen-to-carbon ratio which better reflect the n-alkane content of jet fuels.



SUBSTITUENTS OF DODECANE:
*Acyclic alkane
*Alkane
*Aliphatic acyclic compound



PREPARATION METHOD OF DODECANE:
1-Hexene is hydroborated with baron trifluoride and sodium borohydride in diglyme.
Aqueous potassium hydroxide is then added followed by aqueous nitrate.
Dodecane is produced as the product.



DODECANE AT A GLANCE:
*An alkane hydrocarbon with light emollient properties
*Feels weightless yet helps ensure supple, smooth skin
*May be plant-derived or synthetic
*Deemed safe as used in cosmetics



CHEMICAL PROPERTIES OF DODECANE:
Dodecane, C12H26, is a flammable, colorless liquid with specific gravity 0.749.
Dodecane occurs in the paraffin fraction of petroleum.
Dodecane is released to the environment by wastewater and spills from laboratory and general use of paraffins, petroleum oils, and tars.



SOLUBILITY OF DODECANE:
Dodecane is miscible with ethyl alcohol, ethyl ether, acetone, chloroform and carbon tetrachloride.
Immiscible with water.



PHYSICAL AND CHEMICAL PROPERTIES OF DODECANE:
Dodecane is colorless transparent liquid, density 0.749, melting point -12℃, boiling point 216.2℃, it dissoves in aether and chloroform, but it doesn’t dissolves in water.



STORAGE OF DODECANE:
Keep Dodecane away from heat, sparks, and flame.
Keep Dodecane away from sources of ignition.
Store Dodecane in a cool, dry place.
Store Dodecane in a tightly closed container.
Store Dodecane in a cool, dry, well-ventilated area away from incompatible substances.



PRODUCTION METHODS OF DODECANE:
Dodecane is isolated from the kerosene and gas oil fractions of crude oil by selective adsorption and subsequent desorption to yield mixtures of paraffins that can be separated by fractional distillation.



REACTIVITY PROFILE OF DODECANE:
*Saturated aliphatic hydrocarbons, such as Dodecane, may be incompatible with strong oxidizing agents like nitric acid.
*Charring of the hydrocarbon may occur followed by ignition of unreacted hydrocarbon and other nearby combustibles.
*In other settings, aliphatic saturated hydrocarbons are mostly unreactive.
*They are not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents.
*When heated sufficiently or when ignited in the presence of air, oxygen or strong oxidizing agents, they burn exothermically to produce carbon dioxide and water.



PHYSICAL and CHEMICAL PROPERTIES of DODECANE:
Chemical formula: C12H26
Molar mass: 170.340 g·mol−1
Appearance: Colorless liquid
Odor: Gasoline-like to odorless
Density: 0.7495 g mL−1 at 20 °C
Melting point: −10.0 to −9.3 °C; 14.1 to 15.2 °F; 263.2 to 263.8 K
Boiling point: 214 to 218 °C; 417 to 424 °F; 487 to 491 K
Log P: 6.821
Vapor pressure: 18 Pa (at 25 °C)
Henry's law constant (kH): 1.4 nmol Pa−1 kg−1
Refractive index (nD): 1.421
Viscosity: 1.34 mPa s
Thermochemistry:
Heat capacity (C): 376.00 J K−1 mol−1
Std molar entropy (S⦵298): 490.66 J K−1 mol−1
Std enthalpy of formation (ΔfH⦵298): −353.5–−350.7 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): −7901.74 kJ mol−1
Product name: N-Dodecane

CAS NO.: 112-40-3
Assay: 98% min
Molecular formula: C12H26
Molecular weight: 170.34
Molecular Weight: 170.33 g/mol
XLogP3: 6.1
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 0
Rotatable Bond Count: 9
Exact Mass: 170.203450829 g/mol
Monoisotopic Mass: 170.203450829 g/mol
Topological Polar Surface Area: 0 Ų
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 56.4

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CAS number: 112-40-3
EC number: 203-967-9
Hill Formula: C₁₂H₂₆
Chemical formula: CH₃(CH₂)₁₀CH₃
Molar Mass: 170.34 g/mol
HS Code: 2901 10 00

Boiling point: 216.3 °C (1013 hPa)
Density: 0.753 g/cm3 (15 °C)
Explosion limit: 0.6% (V)
Flash point: 70 °C
Ignition temperature: 200 °C
Melting Point: -10 °C
Vapor pressure: 0.2 hPa (25 °C)
Viscosity kinematic: CAS Index Name: Dodecane
Molecular formula: C12H26
Molecular weight: 170.34
Lipid number: C12
Smiles: CCCCCCCCCCC
Isomeric Smiles: C(CCCCCC)CCCCC

InChI: InChI=1S/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H3
InChIKey: InChIKey=SNRUBQQJIBEYMU-UHFFFAOYSA-N
MDL Number: MFCD00008969
PubChem CID: 8182
ChEBI: CHEBI:28817
IUPAC Name: Dodecane
SMILES: CCCCCCCCCCCC
Color: Colorless
Density: 0.753 g/cm³ at 25°C
Assay Percent Range: >99%
Quantity: 100 mL
Formula Weight: 170.34
Percent Purity: 99.5%
Physical Form: Liquid
Chemical Name or Material: N-dodecane

Boiling Point/Range: 215-217 °C
Color: Colorless
Density: 0.75 g/cm³
Flashpoint: 70 °C
Form: Liquid
Grade: Reagent Grade
Incompatible Materials: Strong oxidizing agents
Lower Explosion Limit: 0.6% (V)
Melting Point/Range: -9.6 °C
Partition Coefficient: 6.98 (25 °C)
Purity Percentage: ≥99.00%
Solubility in Water: Insoluble
Upper Explosion Limit: No data available
Vapor Pressure: 1 hPa (47.8 °C)
Viscosity: No data available
Storage Temperature: Ambient

Water Solubility: 0.00018 g/L
logP: 6.42
logP: 5.8
logS: -6
Physiological Charge: 0
Hydrogen Acceptor Count: 0
Hydrogen Donor Count: 0
Polar Surface Area: 0 Ų
Rotatable Bond Count: 9
Refractivity: 57.01 m³·mol⁻¹
Polarizability: 24.83 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: No
Ghose Filter: No
Veber's Rule: Yes
MDDR-like Rule: No

Chemical Formula: C12H26
IUPAC name: dodecane
InChI Identifier: InChI=1S/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H3
InChI Key: SNRUBQQJIBEYMU-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCCCCCCC
Average Molecular Weight: 170.3348
Monoisotopic Molecular Weight: 170.203450832
Boiling Point: Not Available
Charge: Not Available
Density: Not Available
Experimental logP: 6.10
Experimental pKa: Not Available
Experimental Water Solubility: 3.7e-06 mg/mL at 25 °C
Isoelectric point: Not Available
Mass Composition: Not Available

Melting Point: -9.6 °C
Optical Rotation: Not Available
CBNumber: CB5678167
Molecular Formula: C12H26
Molecular Weight: 170.33
MDL Number: MFCD00008969
MOL File: 112-40-3.mol
Melting point: -9.6 °C (lit.)
Boiling point: 215-217 °C (lit.)
Density: 0.75 g/mL at 25 °C (lit.)
Vapor density: 5.96 (vs air)
Vapor pressure: 1 mm Hg (47.8 °C)
Refractive index: n20/D 1.421 (lit.)

Flash point: 181.4 °F
Storage temp: Store below +30°C.
Solubility: Soluble in acetone, alcohol, chloroform,
ether, and many hydrocarbons
Form: Liquid
pKa: >14
Specific Gravity: 0.749 (20/4 °C)
Color: Colorless
Odor: Alkane
Odor Threshold: 0.11 ppm
Viscosity: 1.98 mm2/s
Explosive limit: 0.6% (V)
Water Solubility: BRN: 1697175

Henry's Law Constant: 29.7 (atm·m3/mol) at 25 °C
Dielectric constant: 2.0 (20 °C)
InChIKey: SNRUBQQJIBEYMU-UHFFFAOYSA-N
LogP: 6.100
CAS DataBase Reference: 112-40-3
EWG's Food Scores: 1
FDA UNII: 11A386X1QH
NIST Chemistry Reference: n-Dodecane(112-40-3)
EPA Substance Registry System: Dodecane (112-40-3)
Boiling Point: Not Available
Charge: Not Available
Density: Not Available
Experimental logP: 6.10
Experimental pKa: Not Available
Experimental Water Solubility: 3.7e-06 mg/mL at 25 °C

Isoelectric point: Not Available
Mass Composition: Not Available
Melting Point: -9.6 °C
Optical Rotation: Not Available
CBNumber: CB5678167
Molecular Formula: C12H26
Molecular Weight: 170.33
MDL Number: MFCD00008969
MOL File: 112-40-3.mol
Melting point: -9.6 °C (lit.)
Boiling point: 215-217 °C (lit.)
Density: 0.75 g/mL at 25 °C (lit.)
Vapor density: 5.96 (vs air)
Vapor pressure: 1 mm Hg (47.8 °C)

Refractive index: n20/D 1.421 (lit.)
Flash point: 181.4 °F
Storage temp: Store below +30°C.
Solubility: Soluble in acetone, alcohol, chloroform,
ether, and many hydrocarbons
Form: Liquid
pKa: >14 (Schwarzenbach et al., 1993)
Specific Gravity: 0.749 (20/4 °C)
Color: Colorless
Odor: Alkane
Odor Threshold: 0.11 ppm
Viscosity: 1.98 mm2/s

Explosive limit: 0.6% (V)
Water Solubility: BRN: 1697175
Henry's Law Constant: 29.7 (atm·m3/mol) at 25 °C
Dielectric constant: 2.0 (20 °C)
InChIKey: SNRUBQQJIBEYMU-UHFFFAOYSA-N
LogP: 6.100
CAS DataBase Reference: 112-40-3(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 11A386X1QH
NIST Chemistry Reference: n-Dodecane(112-40-3)
EPA Substance Registry System: Dodecane (112-40-3)



FIRST AID MEASURES of DODECANE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Call a physician immediately.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DODECANE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of DODECANE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DODECANE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 30 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A (acc. to DIN 3181)
-Control of environmental exposure:
Do not let product enter drains



HANDLING and STORAGE of DODECANE:
-Precautions for safe handling:
*Advice on protection against fire and explosion:
Take precautionary measures against static discharge.
*Hygiene measures:
Change contaminated clothing.
Preventive skin protection recommended.
Wash hands after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep locked up or in an area accessible only to qualified or authorized persons.
Handle and store under inert gas.
Hygroscopic



STABILITY and REACTIVITY of DODECANE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .

1,10-Decanedicarboxylic acid; 1,12-Dodecanedioic acid; Decamethylenedicarboxylic acid; Dodecandisäure (German); ácido dodecanodioico (Spanish); Acide dodécanedioïque (French); Dodecane-1,12-dicarboxylic acid; n-Decane-omega,omega'-dicarboxylic acid CAS NO: 693-23-2

DESCRIPTION:

Dodecanedioic Acid (Corfree M1) is a nitrite-free dibasic acid mixture, primarily C11 and C12, which provides excellent ferrous corrosion inhibition properties.
Dodecanedioic Acid (Corfree M1)is used in a variety of corrosion inhibitor applications, including metalworking fluids, engine coolants, metal cleaners, aqueous hydraulic fluids, and die cast release agents.
When formulated as an amine salt, Dodecanedioic Acid (Corfree M1)dibasic acid provides superior corrosion protection to alternatives such as sebacic acid, azelaic acid, and long-chain monobasic acids.

CAS No.72162-23-3
Molecular Formula:C24H47NO5
Formula Weight:429.64


Dodecanedioic Acid (Corfree M1)dibasic acid formulations do not leave undesirable, hard-to-clean residues associated with amine borate formulations.


SAFETY INFORMATION ABOUT DODECANEDIOIC ACID (CORFREE M1):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



CHEMICAL AND PHYSICAL PROPERTIES OF DODECANEDIOIC ACID (CORFREE M1):
Melting point 85-95 °C(lit.)
Density 1.02 g/mL at 25 °C(lit.)
vapor pressure 0.002Pa at 20℃
pka 4.45[at 20 ℃]
Appearance White/Off white flake
Total dibasic acids (wt %) ≥ 98.0
C10 through C12 dibasic acid (wt %) ≥ 95.0
Water (wt %) <0.5
Water Solubility (25 ºC) (wt %)
as dibasic acid <0.05
as TEA amine salt >10


SYNONYMS OF DODECANEDIOIC ACID (CORFREE M1):
CORMIX I
CORFREE?M1
corfree(R)mi
CORFREE(R) M1
C10-12 Alkanedioic acid
Dibasic acids CorMix II
Dibasic acids COFREE M1
uctsfrom,high-boilingfraction
dodecanedioic acid and sebacic acid
corfreem1(mixtureofundecanedioicacid

Dodecanoic Acid is a white, powdery solid with a faint odor of bay oil or soap.
Dodecanoic Acid, Reagent, also known as Dodecoic acid, is a medium chain fatty acid that has a vague smell of soap and is a powder.


CAS Number: 143-07-7
EC Number: 205-582-1
MDL Number: MFCD00004440
Molecular formula: C10H18O4 / HOOC(CH2)8COOH



SYNONYMS:
Dodecanoic acid, n-Dodecanoic acid, Dodecylic acid, Dodecoic acid, Laurostearic acid, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, C12:0 (Lipid numbers), Laurostearic acid, Laurates, NSC 5026, Vulvic acid, 1-Dodecanoic acid, Dodecanoates, Lauric acid, Dodecylic acid, 1-Undecanecarboxylic acid, FA12:0, n-Dodecanoic acid, lauric acid, n-dodecanoic acid, dodecylic acid, vulvic acid, laurostearic acid, dodecoic acid, duodecylic acid, 1-undecanecarboxylic acid, aliphat no. 4, neo-fat 12, Decanedioic acid, 1,8-Octanedicarboxylic acid, Decane-1,10-dioic acid, sebacic acid, DECANEDIOIC ACID, 111-20-6, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid, Sebacic acids, Sebacinsaure, Decanedicarboxylic acid, n-Decanedioic acid, Acide sebacique, Sebacinsaeure, USAF HC-1, Ipomic acid, Seracic acid, Decanedioic acid, homopolymer, NSC 19492, UNII-97AN39ICTC, 1,8-dicarboxyoctane, 26776-29-4, NSC19492, 97AN39ICTC, octane-1,8-dicarboxylic acid, CHEBI:41865, NSC-19492, DSSTox_CID_6867, DSSTox_RID_78231, DSSTox_GSID_26867, SebacicAcid, CAS-111-20-6, CCRIS 2290, EINECS 203-845-5, BRN 1210591, n-Decanedioate, Iponic acid, AI3-09127, disodium-sebacate, 4-oxodecanedioate, MFCD00004440, 1,10-Decanedioate, Sebacic acid, 94%, Sebacic acid, 99%, Dicarboxylic acid C10, 1i8j, 1l6s, 1l6y, 1,8-Octanedicarboxylate, WLN: QV8VQ, SEBACIC ACID, EC 203-845-5, SCHEMBL3977, NCIOpen2_008624, SEBACIC ACID, 4-02-00-02078, SEBACIC ACID, CHEMBL1232164, DTXSID7026867, Sebacic acid, >=95.0% (GC), ZINC1531045, Tox21_201778, Tox21_303263, BBL011473, LMFA01170006, s5732, STL146585, AKOS000120056, CCG-266598, CS-W015503, DB07645, GS-6713, HY-W014787, NCGC00164361-01, NCGC00164361-02, NCGC00164361-03, NCGC00257150-01, NCGC00259327-01, BP-27864, NCI60_001628, DB-121158, FT-0696757, C08277, A894762, C10-120, C10-140, C10-180, C10-220, C10-260, C10-298, Q413454, Q-201703, Z1259273339, 301CFA7E-7155-4D51-BD2F-EB921428B436, 1,8-Octanedicarboxylic acid, Decanedioic acid, Octane-1,8-dicarboxylic acid, 1,10-Decanedioic Acid, 1,8-Octanedicarboxylic Acid, NSC 19492, NSC 97405, n-Decanedioic Acid, 1,10-Decanedioate, 1,10-Decanedioic acid, 1,8-Dicarboxyoctane, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4,7-dioxosebacic acid, 4-Oxodecanedioate, 4-oxodecanedioate, 4-Oxodecanedioic acid, 1,10-Decanedioic acid, 1,8-Dicarboxyoctane, Decanedioic acid, Sebacinsaeure, 1,10-Decanedioate, Decanedioate, Sebacate, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4-Oxodecanedioate, 4-Oxodecanedioic acid, Acide sebacique, Decanedicarboxylic acid, Dicarboxylic acid C10, Ipomic acid, N-Decanedioate, N-Decanedioic acid, Sebacic acids, Sebacinsaure, Seracic acid, Sebacic acid, aluminum salt, Sebacic acid, monocadmium salt, Sebacic acid, sodium salt, DECANEDIOIC ACID, sebacic, USAF hc-1, acidesebacique, SEBACIC ACID pure, n-Decanedioic acid, 1,10-Decanedioic acid, Decanedicarboxylic acid, sebacate (decanedioate), 1,8-OCTANEDICARBOXYLIC ACID, 1,10-Decanedioate, 1,10-Decanedioic acid, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4-Oxodecanedioate, 4-Oxodecanedioic acid, Acide sebacique, Decanedicarboxylic acid, Decanedioate, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid, n-Decanedioic acid, 4-Oxodecanedioate, 1,8-Dicarboxyoctane, Octane-1,8-dicarboxylic acid, Sebacic acid, Ipomic acid, Seracic acid, lauric acid, DODECANOIC ACID, 143-07-7, n-Dodecanoic acid, Dodecylic acid, Laurostearic acid, Vulvic acid, Dodecoic acid, Duodecylic acid, 1-Undecanecarboxylic acid, Aliphat No. 4, Ninol AA62 Extra, Wecoline 1295, Hydrofol acid 1255, Hydrofol acid 1295, Duodecyclic acid, Hystrene 9512, Univol U-314, Lauric acid, pure, Dodecylcarboxylate, Lauric acid (natural), Laurinsaeure, Undecane-1-carboxylic acid, ABL, NSC-5026, FEMA No. 2614, laurate, C-1297, Philacid 1200, CCRIS 669, C12:0, Emery 651, Lunac L 70, CHEBI:30805, HSDB 6814, EINECS 205-582-1, UNII-1160N9NU9U, BRN 1099477, n-Dodecanoate, Kortacid 1299, Dodecanoic Acid Anion, DTXSID5021590, Prifrac 2920, AI3-00112, Lunac L 98, Univol U 314, Prifac 2920, 1160N9NU9U, MFCD00002736, DAO, DTXCID801590, CH3-[CH2]10-COOH, NSC5026, EC 205-582-1, dodecylate, laurostearate, vulvate, 4-02-00-01082 (Beilstein Handbook Reference), DODECANOIC ACID (LAURIC ACID), 1-undecanecarboxylate, LAURIC ACID (USP-RS), LAURIC ACID [USP-RS], CH3-(CH2)10-COOH, 8000-62-2, CAS-143-07-7, SMR001253907, laurinsaure, dodecanic acid, Nuvail, lauric-acid, Acide Laurique, 3uil, Lauric acid (NF), DODECANOICACID, fatty acid 12:0, Lauric Acid, Reagent, Nissan NAA 122, Emery 650, Dodecanoic acid, 98%, Dodecanoic acid, 99%, Guaranteed Reagent,99%, Dodecanoic (Lauric) acid, LAURIC ACID [MI], bmse000509, LAURIC ACID [FCC], LAURIC ACID [FHFI], SCHEMBL5895, NCIOpen2_009480, MLS002177807, MLS002415737, WLN: QV11, Dodecanoic acid (lauric acid), LAURIC ACID [WHO-DD], Dodecanoic acid, >=99.5%, Edenor C 1298-100, DODECANOIC ACID [HSDB], CHEMBL108766, GTPL5534, NAA 122, NAA 312, HMS2268C14, HMS3649N06, HY-Y0366, STR08039, Dodecanoic acid, analytical standard, Lauric acid, >=98%, FCC, FG, Tox21_202149, Tox21_303010, BDBM50180948, LMFA01010012, s4726, STL281860, AKOS000277433, CCG-266587, DB03017, FA 12:0, HYDROFOL ACID 1255 OR 1295, NCGC00090919-01, NCGC00090919-02, NCGC00090919-03, NCGC00256486-01, NCGC00259698-01, AC-16451, BP-27913, DA-64879, Dodecanoic acid, >=99% (GC/titration), LAU, Dodecanoic acid, purum, >=96.0% (GC), Lauric acid, natural, >=98%, FCC, FG, CS-0015078, L0011, NS00008441, EN300-19951, C02679, D10714, A808010, LAURIC ACID (CONSTITUENT OF SAW PALMETTO), Q422627, SR-01000838338, J-007739, SR-01000838338-3, BRD-K67375056-001-07-9, F0001-0507, LAURIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC], Z104476194, 76C2A2EB-E8BA-40A6-8032-40A98625ED7B, Lauric acid, European Pharmacopoeia (EP) Reference Standard, Lauric acid, United States Pharmacopeia (USP) Reference Standard, Lauric Acid, Pharmaceutical Secondary Standard; Certified Reference Material, 203714-07-2, 7632-48-6, InChI=1/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14, 1-Undecanecarboxylate, 1-Undecanecarboxylic acid, ABL, Acide Laurique, C12 fatty acid, C12:0, Coconut oil fatty acids, DAO, Dodecanoate, dodecanoic acid, dodecoate, Dodecoic acid, Dodecylate, dodecylcarboxylate, Dodecylic acid, duodecyclate, Duodecyclic acid, duodecylate, Duodecylic acid, LAP, LAU, Laurate, Lauric acid, Laurinsaeure, Laurostearate, Laurostearic acid, MYR, n-Dodecanoate, n-Dodecanoic acid, Sorbitan laurate, Sorbitan monolaurate (NF), undecane-1-carboxylate, Undecane-1-carboxylic acid, Vulvate, Vulvic acid, CH3-[CH2]10-COOH, Dodecylcarboxylic acid, Laate, Laic acid, Aliphat no. 4, Edenor C 1298-100, Emery 651, Hystrene 9512, Kortacid 1299, Lunac L 70, Lunac L 98, Neo-fat 12, Neo-fat 12-43, Nissan naa 122, Philacid 1200, Prifac 2920, Univol u 314, 1-Dodecanoic acid, FA(12:0), 1-Undecanecarboxylic acid, ABL, Aliphat no. 4, C12 fatty acid, Coconut oil fatty acids, Dodecanoate, Dodecanoic (lauric) acid, Dodecanoic acid (lauric acid), Dodecoic acid, Dodecylcarboxylate, Dodecylic acid, Duodecyclic acid, Duodecylic acid, Emery 650, Lauric acid, Lauric acid, pure, Laurinsaeure, Laurostearic acid, Lunac L 70, n-Dodecanoic Acid, N-Dodecanoate, Neo-fat 12, Ninol aa62 extra, Undecane-1-carboxylic acid, Univol U 314, Univol U-314, Vulvic acid, AI3-00112, BRN 1099477, C-1297, CCRIS 669, EINECS 205-582-1, FEMA NO. 2614, HSDB 6814, HYDROFOL ACID 1255, HYDROFOL ACID 1295, HYSTRENE 9512, NEO-FAT 12-43, PHILACID 1200, PRIFRAC 2920, WECOLINE 1295, 1-Undecanecarboxylic acid, ABL, AC-16451, AC1L1GY2, AC1Q5W8C, AKOS000277433, Aliphat No. 4, CH3-[CH2]10-COOH, Coconut oil fatty acids, DAO, DODECANOIC ACID, DODECANOIC ACID (LAURIC ACID), Dodecanoate, Dodecanoic (Lauric) acid, Dodecanoic acid (lauric acid), Dodecanoic acid(Lauric acid), Dodecoic acid, Dodecylcarboxylate, Dodecylic acid, Duodecyclic acid, Duodecylic acid, Emery 650, Hydrofol acid 1255, Hydrofol acid 1295, Hystrene 9512, I04-1205, L-ALFA-LYSOPHOSPHATIDYLCHOLINE, LAUROYL, L0011, LAP, LAU, Lauric acid, pure, Laurinsaeure, Laurostearic acid, Lunac L 70, Neo-fat 12, Neo-fat 12-43, Ninol AA62 Extra, Philacid 1200, Prifrac 2920, SMR001253907, ST023796, Undecane-1-carboxylic acid, Univol U-314, Vulvic acid, Wecoline 1295, [2-((1-OXODODECANOXY-(2-HYDROXY-3-PROPANYL))-PHOSPHONATE-OXY)-ETHYL]-TRIMETHYLAMMONIUM, n-Dodecanoate, n-Dodecanoic acid, nchembio.364-comp10, Dodecanoic acid, n-Dodecanoic acid, Neo-fat 12, Aliphat no. 4, Abl, Dodecylic acid, Lauric acid, Laurostearic acid, Neo-fat 12-43, Ninol aa62 extra, Univol u-314, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, C-1297, Coconut oil fatty acids, Hydrofol acid 1255, Hydrofol acid 1295, Wecoline 1295, Dodecoic acid, Hystrene 9512, Lunac L 70, Duodecyclic acid, Emery 650, n-Dodecanoate, Philacid 1200, Prifrac 2920, Undecane-1-carboxylic acid, C-1297, dodecanoic acid, dodecoic acid, duodecylic acid, ndodecanoic acid, Hydrofol acid 1255, Hydrofol acid 1295, Hystrene 9512, laurostearic acid, Neo-fat 12, Neo-fat 12-43, Ninol AA62 Extra, 1-undecanecarboxylic acid, vulvic acid, Wecoline 1295, Dodecoic acid, Duodecyclic acid, Edenor C 1298-100, Emery 650, Hydrofol acid 1295, Hystrene 9512, Kortacid 1299, Laurostearate, Lunac L 70, Lunac L 98, Neo-fat 12, Ninol AA62 extra, Nissan naa 122, Philacid 1200, Prifac 2920, Prifrac 2920, Univol U 314, Vulvate, Vulvic acid, Wecoline 1295, 1-Undecanecarboxylate, 1-Undecanecarboxylic acid, Dodecylate, Dodecylcarboxylate, Dodecylic acid, Duodecylic acid, Laurostearic acid, n-Dodecanoic acid, Undecane-1-carboxylic acid, LAP, LAU, DAO, lauric acid, n-dodecanoic acid, dodecylic acid, vulvic acid, laurostearic acid, dodecoic acid, duodecylic acid, 1-undecanecarboxylic acid, aliphat no. 4, neo-fat 12, 143-07-7, 205-582-1, 1-UNDECANECARBOXYLIC ACID, DODECANOIC ACID, DODECANOIC ACID [HSDB], DODECOIC ACID, FEMA NO. 2614, LAURATE, LAURIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC], LAURIC ACID [FCC], LAURIC ACID [FHFI], LAURIC ACID [MI], LAURIC ACID [USP-RS], LAURIC ACID [WHO-DD], LAUROSTEARIC ACID, N-DODECANOIC ACID, NSC-5026, Dodecanoic acid, Lauric acid, Laurostearic acid, 1-Undecanecarboxylic acid, ABL, Aliphat No. 4, Univol U 314, Dodecylic acid, Vulvic acid, Neo-Fat 12-43, n-Dodecanoic acid, Neo-Fat 12, Lunac L 70, Emery 651, Prifac 2920, Nissan NAA 122, Lunac L 98, Hystrene 9512, NAA 312, Kortacid 1299, Philacid 1200, Edenor C 1298-100, NSC 5026, NAA 122, Prifac 2922, Edenor C 12, Prifrac 2920, ContraZeck, 1-Dodecanoic acid, Imex C 1299, Palmac 98-12, Edenor 12/98-100, Palmera B 1231, Edenor C 12-98-100, Lasacid FC 12, Laurates, Dodecanoates, Palmae 99-12, D 97385, Edenor C12-99, Coconut Hard 34, Coconut Hard 42, Radiacid 0624, NS 6, 7632-48-6, 8000-62-2, 8045-27-0, 203714-07-2, 55621-34-6, DODECANOIC ACID, C12, Emery651, Vulvic acid, FEMA 2614, lauric acid, pure, N-DODECANOIC ACID, LAUROSTEARIC ACID, Lauric acid 98-101 % (acidimetric), Fatty acid methyl ester sulfonate (MES), Dodecanoic D23 Acid, Dodecanoic Acid-d23,1-Dodecanoic Acid-d23, 1-Undecanecarboxylic Acid-d23, ABL-d23, Aliphat No. 4-d23, ContraZeck-d23, Dodecylic Acid-d23, Edenor C 12-d23,Edenor C 1298-100-d23, Emery 651-d23, Hystrene 9512-d23, Imex C 1299-d23, Kortacid 1299-d23, Laurostearic Acid-d23, Lunac L 70-d23, Lunac L 98-d23, NAA 122-d23, NAA 312-d23, NSC 5026-d23, Neo-Fat 12-d23, Neo-Fat 12-43-d23, Nissan NAA 122-d23, Philacid 1200-d23, Prifac 2920-d23, Prifac 2922-d23, Prifrac 2920-d23, Univol U 314-d23, Vulvic Acid-d23, n-Dodecanoic Acid-d23, Dodecanoate, Coconut Oil Fatty Acids, Laurostearic Acid, N-Dodecanoic Acid, C12 Fatty Acid, Duodecyclic Acid, Vulvic Acid, Dodecanoic Acid (Lauric Acid), Duodecylic Acid, N-Dodecanoate, Dodecanoic (Lauric) Acid, Laurinsaeure, Lauric Acid, Pure, Lauric Acid (Natural), Dodecylcarboxylate, Abl, Dao, Lap, Lau, Myr



Dodecanoic Acid is a saturated fatty acid with the structural formula CH3(CH2)10COOH .
Dodecanoic Acid is the main acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
Dodecanoic Acid is also found in human milk(5.8% of total fat), cows milk(2.2%), and goat milk(4.5%).


Dodecanoic Acid is a white, powdery solid with a faint odor of bay oil or soap.
Dodecanoic Acid, Reagent, also known as dodecanoic acid, is a medium chain fatty acid that has a vague smell of soap and is a powder.
Dodecanoic Acid is found naturally in human breast milk as well as cow's and goat's milk.


Dodecanoic Acid's reagent grade means this is the highest quality commercially available for this chemical and that the American Chemical Society has not officially set any specifications for this material.
Dodecanoic Acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.


Dodecanoic Acid is a solid at room temperature but melts easily in boiling water, so liquid Dodecanoic Acid can be treated with various solutes and used to determine their molecular masses.
Dodecanoic Acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.


Dodecanoic Acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Dodecanoic Acid are known as laurates.
Dodecanoic Acid is a saturated fatty acid with a terminal carboxylic acid.


The terminal carboxylic acid, Dodecanoic Acid, can react with primary amine groups in the presence of activators such as HATU.
Dodecanoic Acid is a carbon 13 labeled form of a saturated fatty acid found in coconut milk, coconut oil, laurel oil, and palm kernel oil, as well as in human breast milk and other animal milks.


Dodecanoic Acid is a proton pump inhibitor potentially for the treatment of helicobacter pylori infections.
In vitro experiments have suggested that some fatty acids including Dodecanoic Acid could be a useful component in a treatment for acne, but no clinical trials have yet been conducted to evaluate this potential benefit in humans.


Dodecanoic Acid increases total serum cholesterol more than many other fatty acids.
But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol).
As a result, Dodecanoic Acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid, either saturated or unsaturated.


Dodecanoic Acid, identified by CAS number 143-07-7, is a saturated medium-chain fatty acid with a 12-carbon atom backbone, prominently known for its role in the manufacturing of soaps, detergents, and cosmetics.
As a fundamental component, Dodecanoic Acid is celebrated for its surfactant properties, which enable the production of a rich lather in cleansing products.


In research, Dodecanoic Acid is extensively used to study lipid behavior in various systems due to its amphiphilic nature, which allows it to assemble into micelles and other nanostructures in aqueous solutions.
These studies are crucial for advancing the fields of material science and nanotechnology, particularly in the development of delivery systems and the enhancement of product formulations.


Additionally, Dodecanoic Acid is employed in food science research where it serves as a model to understand the digestion and metabolism of medium-chain fatty acids.
Dodecanoic Acid's antimicrobial properties are also examined in terms of how they can be leveraged in non-medical applications, such as in food preservation and safety, where reducing microbial growth is essential.


Moreover, Dodecanoic Acid′s role in industrial applications extends to its use as a raw material in the synthesis of various chemical derivatives, including esters used in flavorings and fragrances, showcasing its versatility and importance in both scientific research and industrial applications.
Dodecanoic Acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


Dodecanoic Acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
Dodecanoic Acid, C12H24O2, also known as dodecanoic acid, is a saturated fatty acid with a 12-carbon atom chain.
The powdery, white crystalline acid, Dodecanoic Acid, has a slight odor of oil of bay and occurs naturally in various plant and animal fats and oils.


Dodecanoic Acid is a major component of coconut oil and palm kernel oil.
Dodecanoic Acid, CAS 143-07-7, chemical formula C12H24O2, is produced as a white crystalline powder, has a slight odor of bay oil, and is soluble in water, alcohols, phenyls, haloalkanes, and acetates.


Dodecanoic Acid is non-toxic, safe to handle, inexpensive, and has a long shelf life.
Dodecanoic Acid is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids.
Dodecanoic Acid is a white, powdery solid with a faint odor of bay oil or soap.


Dodecanoic Acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
Dodecanoic Acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


Dodecanoic Acid is a potentially toxic compound.
Dodecanoic Acid has the chemical formula C12H24O2.
Dodecanoic Acid appears as a white crystalline solid with a characteristic odor like oil of bay.


Dodecanoic Acid is insoluble in Water and soluble in Ether, Chloroform, and Alcohol.
Dodecanoic Acid is found naturally in some plant and animal fats and is a key component of coconut oil.
Dodecanoic Acid is synthetically prepared by the fractional distillation of other acids of mixed coconut.


Dodecanoic Acid is a white solid with a slight odor of bay oil.
Dodecanoic acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.


Dodecanoic Acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.
Dodecanoic Acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
Dodecanoic Acid is a conjugate acid of a dodecanoate.


Dodecanoic Acid derives from a hydride of a dodecane.
Dodecanoic Acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.
Dodecanoic Acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.


Dodecanoic acid is a metabolite found in or produced by Escherichia coli.
Dodecanoic Acid is a natural product found in Ipomoea leptophylla, Arisaema tortuosum, and other organisms with data available.
Dodecanoic Acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


Dodecanoic Acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
Dodecanoic Acid is the main fatty acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
Dodecanoic Acid is a white, powdery solid with a faint odor of bay oil.


Dodecanoic Acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.
Dodecanoic Acid is a metabolite found in or produced by Saccharomyces cerevisiae.
Dodecanoic Acid is a medium-chain saturated fatty acid.


Dodecanoic Acid is found in many vegetable fats and in coconut and palm kernel oils.
Dodecanoic Acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Dodecanoic Acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.
Dodecanoic Acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Dodecanoic Acid are known as laurates.


Dodecanoic Acid is a precursor to dilauroyl peroxide, a common initiator of polymerizations.
Dodecanoic Acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.


Dodecanoic Acid, also known as dodecanoate or lauric acid, belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
Dodecanoic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


Dodecanoic acid is the main fatty acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
Dodecanoic Acid is a white, powdery solid with a faint odour of bay oil.
Dodecanoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.


Dodecanoic Acid is a fatty acid that has been shown to inhibit the growth of bacteria.
Dodecanoic Acid inhibits bacterial growth by binding to the active site of the enzyme dihydrolipoamide acetyltransferase, which catalyzes the conversion of dihydrolipoamide and acetyl-CoA to succinyl-CoA and acetoacetyl-CoA.


Dodecanoic acid also binds to dinucleotide phosphate, which is involved in regulation of phase transition temperature and biological samples.
Dodecanoic acid has also been shown to act as an active inhibitor of fatty acid synthase, an enzyme that catalyzes the synthesis of fatty acids from acetyl-coenzyme A (acetyl-CoA).


This process is essential for bacterial growth.
Dodecanoic acid has synergistic effects with other antibiotics such as ampicillin, erythromycin, and tetracycline.
Dodecanoic Acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


Dodecanoic Acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
Dodecanoic Acid is a medium-length long-chain fatty acid, or lipid, that makes up about half of the fatty acids within coconut oil.
Dodecanoic Acid’s a powerful substance that is sometimes extracted from the coconut for use in developing monolaurin.


Monolaurin is an antimicrobial agent that is able to fight bacteria, viruses, yeasts, and other pathogens.
Because you can’t ingest Dodecanoic Acid alone (it’s irritating and not found alone in nature), you’re most likely to get it in the form of coconut oil or from fresh coconuts.


Though coconut oil is being studied at a breakneck pace, much of the research doesn’t pinpoint what in the oil is responsible for its reported benefits.
Because coconut oil contains much more than just Dodecanoic Acid, it would be a stretch to credit it with all of the coconut oil benefits.
Still, a 2015 analysis suggests that many of the benefits tied to coconut oil are directly linked to Dodecanoic Acid.


Among the benefits, they suggest Dodecanoic Acid could aid weight loss and even protect against Alzheimer’s disease.
Its effects on blood cholesterol levels still need to be clarified.
This research suggests that the benefits of Dodecanoic Acid are due to how the body uses it.


The majority of Dodecanoic Acid is sent directly to the liver, where it’s converted to energy rather than stored as fat.
When compared with other saturated fats, Dodecanoic Acid contributes the least to fat storage.
Dodecanoic Acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.


Dodecanoic Acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Dodecanoic Acid are known as laurates.
Like many other fatty acids, Dodecanoic Acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.


Dodecanoic Acid is mainly used for the production of soaps and cosmetics.
For these purposes, Dodecanoic Acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.


These precursors give mixtures of sodium laurate and other soaps. Dodecanoic Acid occurs as a white crystalline powder
Dodecanoic Acid is a saturated fatty acid with a 12-carbon atom chain used in industrial cleaners, lubricants, soaps, surfactants, agricultural additives, coatings, food additives, textile additives.


Dodecanoic Acid, the saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white, powdery solid with a faint odor of bay oil or soap.
Dodecanoic Acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil.


Otherwise Dodecanoic Acid is relatively uncommon.
Dodecanoic Acid increases total serum cholesterol the most of any fatty acid.
But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol).


As a result, Dodecanoic Acid has been characterized as having "a more favorable effect on total:HDL cholesterol than any other fatty acid, either saturated or unsaturated."
In general, a lower total/HDL serum cholesterol ratio correlates with a decrease in atherosclerotic risk.


For these purposes, Dodecanoic Acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Dodecanoic Acid is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids.
Dodecanoic Acid is a white crystalline carboxylic acid with a faint odor of bay oil or soap.


Dodecanoic Acid has been found at high levels in coconut oil.
Dodecanoic Acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.


Dodecanoic Acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.
Dodecanoic Acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.


Dodecanoic Acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
Dodecanoic Acid is a conjugate acid of a dodecanoate.
Dodecanoic Acid derives from a hydride of a dodecane.


Dodecanoic Acid is a white crystalline carboxylic acid.
Dodecanoic Acid is used as a plasticizer and for making detergents and soaps.
Dodecanoic Acid's glycerides occur naturally in coconut and palm oils.


Dodecanoic Acid is a white solid with a slight odor of bay oil.
Dodecanoic Acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.


Dodecanoic Acid is a white, powdery solid with a faint odour of mild fatty coconut bay oil or soap.
Dodecanoic Acid is the main fatty acid in coconut oil (49%) and in palm kernel oil (47-50%), and is found in lesser amounts in wild nutmeg, human breast milk, cow’s milk, goat milk, watermelon seeds, plum and macadamia nut.


Dodecanoic Acid, although slightly irritating to mucous membranes, has an extremely low toxicity, is inexpensive, has antimicrobial properties and so is used in many soaps and shampoos.
Dodecanoic Acid is a weakly acidic compound.


Dodecanoic Acid is reacted with sodium hydroxide to generate sodium laurate, which is soap.
Dodecanoic acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid either saturated or unsaturated"



USES and APPLICATIONS of DODECANOIC ACID:
Dodecanoic Acid is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Dodecanoic Acid is approved for use as a biocide in the EEA and/or Switzerland, for: repelling or attracting pests.


People also use Dodecanoic Acid as medicine.
People use Dodecanoic Acid for viral infections such as the flu, common cold, genital herpes, and many other conditions, but there is no good scientific evidence to support any use.


Dodecanoic Acid is used in the following products: washing & cleaning products, coating products, fillers, putties, plasters, modelling clay, finger paints, polishes and waxes, air care products and plant protection products.
Other release to the environment of Dodecanoic Acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


Release to the environment of Dodecanoic Acid can occur from industrial use: industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting) and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).


Other release to the environment of Dodecanoic Acid is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


Dodecanoic Acid can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
Dodecanoic Acid is also used as a food additive and an active component in a treatment for acne.


Dodecanoic Acid can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), leather (e.g. gloves, shoes, purses, furniture) and paper used for packaging (excluding food packaging).


Dodecanoic Acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecanoic Acid is also used to measure the molar mass of an unknown substance through freezing point depression.
Dodecanoic Acid is also used as a food additive and an active component in a treatment for acne.


In addition to this, Dodecanoic Acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecanoic Acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecanoic Acid is also used to measure the molar mass of an unknown substance through freezing point depression.


In addition to this, Dodecanoic Acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecanoic Acid is used in the following products: washing & cleaning products, polishes and waxes, adhesives and sealants, cosmetics and personal care products and laboratory chemicals.


Dodecanoic Acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Dodecanoic Acid is used for the manufacture of: textile, leather or fur.


Release to the environment of Dodecanoic Acid can occur from industrial use: formulation of mixtures and in processing aids at industrial sites.
Other release to the environment of Dodecanoic Acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


Dodecanoic Acid is used in the following products: polymers, pH regulators and water treatment products, leather treatment products, coating products, fillers, putties, plasters, modelling clay, finger paints, inks and toners, cosmetics and personal care products, lubricants and greases and textile treatment products and dyes.


Release to the environment of Dodecanoic Acid can occur from industrial use: formulation of mixtures and formulation in materials.
Dodecanoic Acid is used in the following products: washing & cleaning products, leather treatment products, polymers, textile treatment products and dyes, pH regulators and water treatment products and lubricants and greases.


Dodecanoic Acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Dodecanoic Acid is used for the manufacture of: textile, leather or fur.


Release to the environment of Dodecanoic Acid can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and as processing aid.
Release to the environment of Dodecanoic Acid can occur from industrial use: manufacturing of the substance.


Dodecanoic Acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.
Dodecanoic Acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.


In the laboratory, Dodecanoic Acid may be used to investigate the molar mass of an unknown substance via the freezing-point depression.
The choice of Dodecanoic Acid is convenient because the melting point of the pure compound is relatively high (43.8°C).
Its cryoscopic constant is 3.9°C·kg/mol.


By melting Dodecanoic Acid with the unknown substance, allowing it to cool, and recording the temperature at which the mixture freezes, the molar mass of the unknown compound may be determined.
In industry, Dodecanoic Acid is used as an intermediate and as a surface active agent.


Industrial applications of Dodecanoic Acid and its derivatives include the fatty acid as a component of alkyd resins, wetting agents, a rubber accelerator and softener, detergents, and insecticides.
The consumer market uses Dodecanoic Acid in the cleaning, furnishing, and production of personal care products.


In medicine, Dodecanoic Acid is known to increase total serum cholesterol more than many of the other fatty acids.
Common Uses and Applications of Dodecanoic Acid: Additive, Acidifiers, Chemical intermediate, Lubricant, Synthesis of substances, Industries, Chemical Production, Personal Care, and Laboratories.


Dodecanoic Acid is mainly used in the manufacturing of soaps and other cosmetics.
In scientific laboratories, Dodecanoic Acid is often used to investigate the molar mass of unknown substances via freezing-point depression.
In industry, Dodecanoic Acid is used as an intermediate and as a surface active agent.


The consumer market uses Dodecanoic Acid in the cleaning, furnishing, and production of personal care products.
In medicine, Dodecanoic Acid is known to increase total serum cholesterol more than many of the other fatty acids.
Dodecanoic Acid is mainly used in the manufacture and production of soaps and other cosmetics as well as scientific laboratory uses.


Dodecanoic Acid is used as an intermediate and surface active agent in industry and in the manufacture of personal care products in the consumer market.
Dodecanoic Acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecanoic Acid is also used to measure the molar mass of an unknown substance through freezing point depression.


Dodecanoic Acid is also used as a food additive and an active component in a treatment for acne.
In addition to this, Dodecanoic Acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecanoic Acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.


Dodecanoic Acid is also used to measure the molar mass of an unknown substance through freezing point depression.
Dodecanoic Acid is also used as a food additive and an active component in a treatment for acne.
In addition to this, Dodecanoic Acid is a substrate for acylation of certain proteins based on the murine studies.


Dodecanoic Acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecanoic Acid is also used to measure the molar mass of an unknown substance through freezing point depression.
Dodecanoic Acid is also used as a food additive and an active component in a treatment for acne.


In addition to this, Dodecanoic Acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecanoic Acid is generally used to produce cosmetic products but is also used in the laboratory to obtain the molar mass of substances.
Dodecanoic Acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.


Sodium lauryl sulfate is the most common Dodecanoic Acid derived compound used for this purpose.
Because Dodecanoic Acid has a non-polar hydrocarbon tail and a polar carboxylic acid head, it can interact with polar solvents (the most important being water) as well as fats, allowing water to dissolve fats.


This accounts for the abilities of shampoos to remove grease from hair.
Another use is to raise metabolism, believed to derive from Dodecanoic Acid's activation of 20% of thyroidal hormones, otherwise which lay dormant.
This is supposed from Dodecanoic Acid's release of enzymes in the intestinal tract which activate the thyroid.


This could account the metabolism-raising properties of coconut oil.
Because Dodecanoic Acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle, it is often used in laboratory investigations of melting-point depression.


Dodecanoic Acid is a solid at room temperature but melts easily in boiling water, so liquid it can be treated with various solutes and used to determine their molecular masses.
Dodecanoic Acid is widely used in cosmetics and food products.


In pharmaceutical applications Dodecanoic Acid has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery, and intestinal absorption.
Dodecanoic Acid is also useful for stabilizing oil-in-water emulsions.


Dodecanoic Acid has also been evaluated for use in aerosol formulations.
Dodecanoic Acid is used in the production of personal care products via the salt sodium laurate.
Dodecanoic Acid is also studied in metabolic and foodomics research for its potential impact on cardiovascular disease.


Dodecanoic Acid has been used as a reagent to synthesize MnFe2O4 magnetic nanoparticles by seed mediated growth method.
Dodecanoic Acid can undergo esterification with 2-ethylhexanol in the presence of sulfated zirconia catalyst to form 2-ethylhexanoldodecanoate, a biodiesel.
Like many other fatty acids, Dodecanoic Acid is inexpensive, has a long shelf-life, is nontoxic, and is safe to handle.


Dodecanoic Acid is used mainly for the production of soaps and cosmetics.
For these purposes, Dodecanoic Acid is reacted with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.


These precursors give mixtures of sodium laurate and other soaps.
Dodecanoic Acid is used for the preparation of alkyd resins, as well as wetting agents, detergents and pesticides
Dodecanoic Acid is used for peeling vegetables and fruits with a maximum amount of 3.0g/kg.


Dodecanoic Acid is used as defoamer; GB 2760-86 provides for the spices allowed to use; used for the preparation of other food grade additives.
Dodecanoic Acid is widely used in the surfactant industry and can be, according to the classification of surfactants, divided into cationic, anionic, non-ionic and amphoteric type.


The surfactants types of dodecanoic acid are listed in the attached table of this item.
Some surfactants of the derivatives of dodecanoic acid and dodecanol are also antiseptics, such as dodecyl dimethyl benzyl ammonium chloride (geramine), dodecyl dimethyl benzyl ammonium bromide (bromo-geramine) and dodecyl dimethyl (2-phenoxyethyl) ammonium bromide (domiphen bromide).


The dodecyldimethyllammonium-2,4,5-trichlorophenolate in these derivatives can be used as citrus preservative.
Dodecanoic Acid also has many applications in plastic additives, food additives, spices and pharmaceutical industries.
Given its foaming properties, the derivatives of lauric acid (h-dodecanoic acid) are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol.


Dodecanoic Acid is a common constituent of vegetable fats, especially coconut oil and laurel oil.
Dodecanoic Acid may have a synergistic effect in a formula to help fight against mircoorganisms.
Dodecanoic Acid is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.


Dodecanoic Acid is a fatty acid obtained from coconut oil and other veg- etable fats.
Dodecanoic Acid is practically insoluble in water but is soluble in alcohol, chloroform, and ether.


Dodecanoic Acid functions as a lubricant, binder, and defoaming agent.
Dodecanoic Acid is used intermediates of Liquid Crystals
Dodecanoic Acid is also used as a food additive and an active component in a treatment for acne.


-Uses of Dodecanoic Acid in Perfume:
Dodecanoic Acid is used in Butter flavors and in certain Citrus flavor types, mainly in Lemon.
The concentration of Dodecanoic Acid used may vasy from 2 to 40 ppm, calculated upon the finished consumer product.


-Pharmaceutical Applications of Dodecanoic Acid:
pharmaceutical applications it has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery,(14) and intestinal absorption.

Dodecanoic Acid is also useful for stabilizing oil-in-water emulsions.
Dodecanoic Acid has also been evaluated for use in aerosol formulations.



SOLUBILITY OF DODECANOIC ACID:
Dodecanoic Acid is soluble in water, benzene, acetone, alcohol, petroleum ether, dimethyl sulfoxide and dimethyl formamide.
Dodecanoic Acid is slightly soluble in chloroform.



NOTES OF DODECANOIC ACID:
Dodecanoic Acid is incompatible with bases, oxidizing agents and reducing agents.



WHERE TO FIND DODECANOIC ACID:
Dodecanoic Acid is a powerful substance that’s sometimes extracted from the coconut for use in developing monolaurin.
Monolaurin is an antimicrobial agent that’s able to fight pathogens such as bacteria, viruses, and yeasts.



OCCURRENCE OF DODECANOIC ACID:
Dodecanoic Acid, as a component of triglycerides, comprises about half of the fatty-acid content in coconut milk, coconut oil, laurel oil, and palm kernel oil (not to be confused with palm oil).

Otherwise, Dodecanoic Acid is relatively uncommon.
Dodecanoic Acid is also found in human breast milk (6.2% of total fat), cow's milk (2.9%), and goat's milk (3.1%).

In various plants:
*The palm tree Attalea speciosa, a species popularly known in Brazil as babassu – 50% in babassu oil
*Attalea cohune, the cohune palm (also rain tree, American oil palm, corozo palm or manaca palm) – 46.5% in cohune oil
*Astrocaryum murumuru (Arecaceae) a palm native to the Amazon – 47.5% in "murumuru butter"
*Coconut oil 49%
*Pycnanthus kombo (African nutmeg)
*Virola surinamensis (wild nutmeg) 7.8–11.5%
*Peach palm seed 10.4%
*Betel nut 9%
*Date palm seed 0.56–5.4%
*Macadamia nut 0.072–1.1%
*Plum 0.35–0.38%
*Watermelon seed 0.33%
*Viburnum opulus 0.24-0.33%
*Citrullus lanatus (egusi melon)
*Pumpkin flower 205 ppm, pumpkin seed 472 ppm
*Insect
*Black soldier fly Hermetia illucens 30–50 mg/100 mg fat.



ALTERNATIVE PARENTS OF DODECANOIC ACID:
*Dicarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF DODECANOIC ACID:
*Medium-chain fatty acid
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



COMPOUND TYPE OF DODECANOIC ACID:
*Animal Toxin
*Cosmetic Toxin
*Food Toxin
*Industrial/Workplace Toxin
*Metabolite
*Natural Compound
*Organic Compound
*Plasticizer



CHEMICAL PROPERTIES OF DODECANOIC ACID:
Dodecanoic Acid is a colorless needle-like crystals.
Dodecanoic Acid is soluble in methanol, slightly soluble in acetone and petroleum ether.



STABILITY AND STORAGE CONDITIONS OF DODECANOIC ACID:
Dodecanoic Acid is stable at normal temperatures and should be stored in a cool, dry place.



SOURCE AND PREPARATION OF DODECANOIC ACID:
Dodecanoic Acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of Dodecanoic Acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.



OCCURRENCE OF DODECANOIC ACID:
Dodecanoic Acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil (not to be confused with palm oil).
Otherwise Dodecanoic Acid is relatively uncommon.
Dodecanoic Acid is also found in human breast milk ( 6.2 % of total fat), cow's milk (2.9%), and goat's milk (3.1 %).



SAFETY OF DODECANOIC ACID:
Dodecanoic Acid is widely used in cosmetic preparations, in the manufacture of food-grade additives, and in pharmaceutical formulations.
General exposure to Dodecanoic Acid occurs through the consumption of food and through dermal contact with cosmetics, soaps, and detergent products.

Occupational exposure may cause local irritation of eyes, nose, throat, and respiratory tract, although Dodecanoic Acid is considered safe and nonirritating for use in cosmetics.
No toxicological effects were observed when Dodecanoic Acid was administered to rats at 35% of the diet for 2 years.



MEDIUM-CHAIN TRIGLYCERIDES OF DODECANOIC ACID:
Medium-chain triglycerides, or fatty acids, such as Dodecanoic Acid, are characterized by a specific chemical structure that allows your body to absorb them whole.

This makes them more easily digestible--your body processes them as it would carbohydrates, and they are used as a source of direct energy.
Compared to long-chain triglycerides, the type in other saturated fats, MCTs have fewer calories per serving, roughly 8.3 calories per gram rather than the standard 9 calories per gram, according to an article in "Nutrition Review."



NUTRITIONAL AND MEDICAL ASPECTS OF DODECANOIC ACID:
Although 95% of medium-chain triglycerides are absorbed through the portal vein, only 25–30% of Dodecanoic Acid is absorbed through it.
Dodecanoic Acid induces apoptosis in cancer and promotes the proliferation of normal cells by maintaining cellular redox homeostasis.
Dodecanoic Acid increases total serum lipoproteins more than many other fatty acids, but mostly high-density lipoprotein (HDL).

As a result, Dodecanoic Acid has been characterized as having "a more favorable effect on total HDL than any other fatty acid [examined], either saturated or unsaturated".
In general, a lower total/HDL serum lipoprotein ratio correlates with a decrease in atherosclerotic incidence.

Nonetheless, an extensive meta-analysis on foods affecting the total LDL/serum lipoprotein ratio found in 2003 that the net effects of Dodecanoic Acid on coronary artery disease outcomes remained uncertain.
A 2016 review of coconut oil (which is nearly half Dodecanoic Acid) was similarly inconclusive about the effects on cardiovascular disease incidence.



INCLUDING DODECANOIC ACID IN YOUR DIET:
Dodecanoic Acid can be taken as a supplement, but it is most commonly consumed as part of coconut oil or palm kernel oil.
Dodecanoic Acid is considered to be safe based on the amounts generally found in food.

According to NYU Langone Medical Center, coconut and palm kernel oil contain up to 15 percent MCTs, along with a number of other fats.
However, because they are still pure oil, limit your intake of MCTs to stay within the recommended 5 to 7 teaspoons of oil per day as set out by the U.S. Department of Agriculture.

You can use coconut and palm kernel oil for stir-fries because both oils withstand high heat.
They can also be used in baking, adding a natural richness to your food.



PHYSICAL PROPERTIES OF DODECANOIC ACID:
Dodecanoic Acid occurs as a white crystalline powder with a slight odor of bay oil or a fatty odor.
Dodecanoic Acid is a common constituent of most diets; large doses may produce gastrointestinal upset.



CHEMICAL PROPERTIES OF DODECANOIC ACID:
Like many other fatty acids, Dodecanoic Acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.
Dodecanoic Acid is mainly used for the production of soaps and cosmetics.

For these purposes, Dodecanoic Acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.
These precursors give mixtures of sodium laurate and other soaps.



PRODUCTION METHODS OF DODECANOIC ACID:
1. Industrial production methods can be grouped into two categories:
* derived from the saponification or high temperature and pressure decomposition of natural vegetable oils and fats;
* separated from the synthetic fatty acid.

Japan mainly uses coconut oil and palm kernel oil as the raw materials for the preparation of Dodecanoic Acid.
The natural vegetable oils used to produce dodecanoic acid include coconut oil, litsea cubeba kernel oil, palm kernel oil and mountain pepper seed oil.

Other plants oil, such as palm kernel oil, tea tree seed oil and camphor tree seed oil, can also service industry to produce dodecanoic acid.
The residual C12 distillate from the extraction of Dodecanoic Acid, containing a large number of dodecenoic acid, can be hydrogenated at atmospheric pressure, without catalyst, to convert into dodecanoic acid with a yield of more than 86%.

2. Derived from the separation and purification of coconut oil and other vegetable oil.

3. Dodecanoic Acid naturally exists in coconut oil, litsea cubeba kernel oil, palm kernel oil and pepper kernel oil in the form of glyceride.
Dodecanoic Acid can be derived from the hydrolysis of natural oils and fats in industry.
The coconut oil, water and catalyst are added into the autoclave and hydrolyzed to glycerol and fatty acid at 250 ℃ under the pressure of 5MPa.
The content of dodecanoic acid is 45%~80%, and can be further distilled to obtain dodecanoic acid.



AIR AND WATER REACTIONS OF DODECANOIC ACID:
Dodecanoic Acid is insoluble in water.



AROMA THRESHOLD VALUES OF DODECANOIC ACID:
Aroma threshold values
Aroma characteristics at 1.0%: fatty, creamy, cheeselike, candle waxy with egglike richness



TASTE THRESHOLD VALUES OF DODECANOIC ACID:
Taste characteristics at 5 ppm: waxy,fatty and oily, tallowlike, creamy and dairylike with a coating mouthfeel



REACTIVITY PROFILE OF DODECANOIC ACID:
Dodecanoic Acid is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.

Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Dodecanoic Acid to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.



PRODUCTION METHODS OF DODECANOIC ACID:
Dodecanoic Acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of Dodecanoic Acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.



PHYSICAL and CHEMICAL PROPERTIES of DODECANOIC ACID:
Chemical formula: C10H18O4
Molar mass: 202.250 g·mol−1
Density: 1.209 g/cm3
Melting point: 131 to 134.5 °C (267.8 to 274.1 °F; 404.1 to 407.6 K)
Boiling point: 294.4 °C (561.9 °F; 567.5 K) at 100 mmHg
Solubility in water: 0.25 g/L
Acidity (pKa): 4.720, 5.450
Molecular Weight: 202.25
XLogP3: 2.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4

Rotatable Bond Count: 9
Exact Mass: 202.12050905
Monoisotopic Mass: 202.12050905
Topological Polar Surface Area: 74.6 Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 157
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: powder
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 133 - 137 °C - lit.
Initial boiling point and boiling range: 294,5 °C at 133 hPa - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available

Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0,224 g/l at 20 °C - OECD Test Guideline 105
Partition coefficient:
n-octanol/water: log Pow: 1,5 at 23 °C
Vapor pressure: 1 hPa at 183 °C
Density: 1,210 g/cm3 at 20 °C

Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Water Solubility: 0.91 g/L
logP: 1.93
logP: 2.27
logS: -2.4
pKa (Strongest Acidic): 4.72

Physiological Charge: -2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 2
Polar Surface Area: 74.6 Ų
Rotatable Bond Count: 9
Refractivity: 51.14 m³·mol⁻¹
Polarizability: 22.61 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: No
MDDR-like Rule: No

Melting point: 133-137 °C (lit.)
Boiling point: 294.5 °C/100 mmHg (lit.)
Density: 1.21
vapor pressure: 1 mm Hg ( 183 °C)
refractive index: 1.422
Flash point: 220 °C
storage temp.: Store below +30°C.
solubility: ethanol: 100 mg/mL
form: Powder or Granules
pka: 4.59, 5.59(at 25℃)
color: White to off-white
Water Solubility: 1 g/L (20 ºC)
Merck: 14,8415

BRN: 1210591
Stability: Stable.
LogP: 1.5 at 23℃
Appearance: white granular powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 130.80 °C. @ 760.00 mm Hg
Boiling Point: 364.00 to 365.00 °C. @ 760.00 mm Hg
Boiling Point: 235.00 to 234.00 °C. @ 10.00 mm Hg
Flash Point: 389.00 °F. TCC ( 198.30 °C. ) (est)
logP (o/w): 1.706 (est)
Soluble in: water, 1000 mg/L @ 20 °C (exp)
water, 1420 mg/L @ 25 °C (est)

Chemical formula: C12H24O2
Molar mass: 200.322 g·mol−1
Appearance: White powder
Odor: Slight odor of bay oil
Density: 1.007 g/cm³ (24 °C),
0.8744 g/cm³ (41.5 °C),
0.8679 g/cm³ (50 °C)
Melting point: 43.8 °C (110.8 °F; 316.9 K)
Boiling point: 297.9 °C (568.2 °F; 571.0 K),
282.5 °C (540.5 °F; 555.6 K) at 512 mmHg,
225.1 °C (437.2 °F; 498.2 K) at 100 mmHg
Solubility in water: 37 mg/L (0 °C), 55 mg/L (20 °C),
63 mg/L (30 °C), 72 mg/L (45 °C), 83 mg/L (100 °C)

Solubility: Soluble in alcohols, diethyl ether,
phenyls, haloalkanes, acetates
Solubility in methanol: 12.7 g/100 g (0 °C),
120 g/100 g (20 °C), 2250 g/100 g (40 °C)
Solubility in acetone: 8.95 g/100 g (0 °C),
60.5 g/100 g (20 °C), 1590 g/100 g (40 °C)
Solubility in ethyl acetate: 9.4 g/100 g (0 °C),
52 g/100 g (20°C), 1250 g/100 g (40°C)
Solubility in toluene: 15.3 g/100 g (0 °C),
97 g/100 g (20°C), 1410 g/100 g (40°C)
log P: 4.6

Vapor pressure: 2.13·10−6 kPa (25 °C),
0.42 kPa (150 °C),
6.67 kPa (210 °C)
Acidity (pKa): 5.3 (20 °C)
Thermal conductivity: 0.442 W/m·K (solid),
0.1921 W/m·K (72.5 °C),
0.1748 W/m·K (106 °C)
Refractive index (nD): 1.423 (70 °C),
1.4183 (82 °C)
Viscosity: 6.88 cP (50 °C), 5.37 cP (60 °C)
Structure:
Crystal structure: Monoclinic (α-form),
Triclinic, aP228 (γ-form)

Space group: P21/a, No. 14 (α-form), P1, No. 2 (γ-form)
Point group: 2/m (α-form)[8], 1 (γ-form)[9]
Lattice constant: a = 9.524 Å, b = 4.965 Å,
c = 35.39 Å (α-form),
α = 90°, β = 129.22°, γ = 90°
Thermochemistry:
Heat capacity (C): 404.28 J/mol·K
Std enthalpy of formation (ΔfH⦵298): −775.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298): 7377 kJ/mol,
7425.8 kJ/mol (292 K)
Molecular Weight: 200.32 g/mol
XLogP3: 4.2
Hydrogen Bond Donor Count: 1

Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 10
Exact Mass: 200.177630004 g/mol
Monoisotopic Mass: 200.177630004 g/mol
Topological Polar Surface Area: 37.3Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 132
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
IUPAC Name: dodecanoic acid
Traditional IUPAC Name: lauric acid
Formula: C12H24O2
InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChI Key: POULHZVOKOAJMA-UHFFFAOYSA-N
Molecular weight: 200.3178
Exact mass: 200.177630012
SMILES: CCCCCCCCCCCC(O)=O

Chemical Formula: C12H24O2
Average Molecular Weight: 200.3178
Monoisotopic Molecular Weight: 200.177630012
IUPAC Name: dodecanoic acid
Traditional Name: lauric acid
CAS Registry Number: 143-07-7
SMILES: CCCCCCCCCCCC(O)=O
InChI Identifier: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChI Key: POULHZVOKOAJMA-UHFFFAOYSA-N
Synonyms: n-Dodecanoic acid
IUPAC Name: Dodecanoic acid
Canonical SMILES: CCCCCCCCCCCC(=O)O
InChI: POULHZVOKOAJMA-UHFFFAOYSA-N

InChI Key: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
Boiling Point: 225 °C 100mmHg(lit.)
Melting Point: 44-46 °C(lit.)
Flash Point: 156ºC
Density: 0.883g/ml
Appearance: Clear liquid
Storage: Room temperature
CNo.Chain: C12:0
Compound Derivative: Acid
EC Number: 205-582-1
Fatty Acid: Dodecanoic (Lauric)
Hazard Codes: Xi

Hazard Statements: Xi
HS Code: 2916399090
LogP: 3.99190
MDL Number: MFCD00002736
Physical State: Solid
PSA: 37.3
Refractive Index: 1.4304
Safety Description: 37/39-26-39-36
Stability: Stable.
Incompatible with bases, oxidizing agents, reducing agents.
Storage Conditions: Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances.

Supplemental Hazard Statements: H401-H318-H319
Symbol: GHS05, GHS07
Vapor Pressure: 1 mm Hg ( 121 °C)
Formula: C12H24O2
InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
Molecular Weight: 200.322 g/mol
SMILES: OC(CCCCCCCCCCC)=O
SPLASH: splash10-0706-9000000000-b974e08e305014657f85
Source of Spectrum: HE-1982-0-0
CB Number: CB0357278
Molecular Formula: C12H24O2
Lewis structure
Molecular Weight: 200.32

MDL Number: MFCD00002736
MOL File: 143-07-7.mol
Melting point: 44-46 °C (lit.)
Boiling point: 225 °C/100 mmHg (lit.)
Density: 0.883 g/mL at 25 °C (lit.)
Vapor pressure: 1 mm Hg (121 °C)
Refractive index: 1.4304
FEMA: 2614 | LAURIC ACID
Flash point: >230 °F
Storage temp.: 2-8°C
Solubility: 4.81 mg/L
Form: Crystalline Powder of Flakes
pKa: 4.92 (H2O, t =25.0) (Uncertain)
Specific Gravity: 0.883
Color: White

Odor: at 100.00 % mild fatty coconut bay oil
Odor Type: fatty
Explosive limit: 0.6% (V)
Water Solubility: insoluble
λmax: 207 nm (MeOH) (lit.)
JECFA Number: 111
Merck: 14,5384
BRN: 1099477
Stability: Stable.
Incompatible with bases, oxidizing agents, reducing agents.
InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
LogP: 5

Dissociation constant: 5.3 at 20°C
Substances Added to Food (formerly EAFUS): LAURIC ACID
CAS DataBase Reference: 143-07-7 (CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 1160N9NU9U
NIST Chemistry Reference: Dodecanoic acid (143-07-7)
EPA Substance Registry System: Lauric acid (143-07-7)
Molecular Weight: 200.32
Exact Mass: 200.32
BRN: 1099477
EC Number: 205-582-1
HS Code: 29159010

Characteristics
PSA: 37.3
XLogP3: 4.2
Appearance: White Crystalline Powder of Flakes
Density: 0.883 g/cm³ @ Temp: 20 °C
Melting Point: 44.2 °C
Boiling Point: 298.9 °C
Flash Point: >230 °F
Refractive Index: 1.4304
Water Solubility: H2O: insoluble
Storage Conditions: Store below +30°C
Vapor Pressure: 1 mm Hg (121 °C)
Toxicity: LD50 i.v. in mice: 131 ±5.7 mg/kg (Or, Wretlind)
Explosive limit: 0.6% (V)
Odor: Characteristic, like oil of bay
pKa: 5.3 (at 20 °C)



FIRST AID MEASURES of DODECANOIC ACID:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DODECANOIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of DODECANOIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DODECANOIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DODECANOIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry



STABILITY and REACTIVITY of DODECANOIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Conditions to avoid:
no information available

Dodecanol is a saturated 12-carbon fatty alcohol obtained from coconut oil fatty acids.
Dodecanol, also known as lauryl alcohol or 1-dodecanol, is a fatty alcohol with the chemical formula CH3(CH2)11OH.
Dodecanol is a colorless, waxy solid at room temperature and has a mild, fatty odor.

CAS Number: 112-53-8
Molecular Formula: C12H26O
Molecular Weight: 186.33
EINECS Number: 203-982-0

Dodecanol has a characteristic fatty odor; unpleasant at high concentrations, but delicate and floral on dilution.
Dodecanol has a fatty, waxy flavor and is used in detergents, lubricating oils, and pharmaceuticals.
Dodecanol is classified as a long-chain alcohol because it contains a 12-carbon chain in its molecular structure.

Dodecanol is a white low melting crystalline solid that has a melting point of 24°C.
The air odor threshold for Dodecanol (isomer not specified) is reported to be 7.1 ppb.
Dodecanol is produced commercially by the oxo process and from ethylene by the Ziegler process, which involves oxidation of trialkylaluminum compounds.

Dodecanol can also be produced by sodium reduction or high-pressure hydrogenation of esters of naturally occurring lauric acid.
Dodecanol, is an organic compound produced industrially from palm kernel oil or coconut oil.
Dodecanol is a fatty alcohol.

Sulfate esters of Dodecanol, especially sodium lauryl sulfate, are very widely used as surfactants.
Dodecanol, ammonium lauryl sulfate, and sodium laureth sulfate are all used in shampoos.
Dodecanol is tasteless and colorless with a floral odor.

Dodecanol is a long chain alkyl alcohol.
Dodecanols density and viscosity over a temperature range, 303.15 to 323.15K have been determined.
The thermodynamics of the interaction between Dodecanol and sodium dodecyl sulfate (SDS) micellar solutions has been reported.

This solvent meets ACS specifications and can be used for processes requiring strict quality conditions such as analytical testing.
Dodecanol, with a chemical formula of C12H26O, is a saturated fatty alcohol derived from coconut oil.
This clear, colorless, and odorless liquid possesses a thick consistency at room temperature.

Dodecanol serves as a versatile surfactant, emollient, and emulsifier, playing a crucial role in the synthesis of numerous compounds.
Furthermore, Dodecanol acts as a solvent for waxes, resins, and dyes, and contributes to the production of detergents, lubricants, and plasticizers.
Although the precise mechanism of action of Dodecanol remains incompletely understood, it is believed to function as a surfactant.

This property enables it to reduce the surface tension of water, facilitating its penetration through cell membranes and interaction with proteins and other molecules.
Dodecanol is used as a surfactant or emulsifier in many products, such as detergents, shampoos, and cosmetics.
Dodecanol helps to mix water and oil-based ingredients and improve the stability of emulsions.

Dodecanol is used in the production of lubricants and metalworking fluids due to its lubricating properties.
Dodecanol can be used as a solvent in the formulation of certain paints, coatings, and inks.
In some cases, dodecanol can act as a plasticizer in the production of plastics and polymers, helping to improve their flexibility and processability.

Dodecanol is sometimes used as a component in the formulation of flavors and fragrances in the food and cosmetic industries.
Dodecanol may be used as an excipient in the pharmaceutical industry for drug formulation.
Dodecanol is a white, crystalline solid at room temperature.

Dodecanol has a melting point of approximately 24-25°C (75-77°F) and a boiling point of around 259-261°C (498-502°F).
Its solubility in water is relatively low, but it is soluble in many organic solvents, such as ethanol and ether.
The chemical structure of dodecanol consists of a hydrophobic hydrocarbon tail (a 12-carbon chain) and a polar hydroxyl (OH) group at the end of the chain.

This structure gives it both hydrophobic (water-repelling) and hydrophilic (water-attracting) properties, making it useful in emulsification and as a surfactant.
Dodecanol can be synthesized through various methods, including the reduction of dodecanoic acid (a fatty acid) or by the hydroformylation of 1-dodecene, followed by hydrogenation to convert the aldehyde group to an alcohol group.

Dodecanol is generally considered safe for use in cosmetics, personal care products, and many industrial applications when used as directed.
However, like many chemicals, it should be handled with care and in accordance with safety guidelines to avoid potential skin or eye irritation.

In addition to the mentioned uses, dodecanol can be found in various other applications.
For example, it is used in the production of certain flavors and fragrances, as an intermediate in the synthesis of other chemicals, and as a component in some types of cleaning agents.
Dodecanol is known by various alternative names, including lauryl alcohol, 1-dodecanol, n-dodecanol, and dodecyl alcohol.

Melting point: 22-26 °C(lit.)
Boiling point: 260-262 °C(lit.)
Density: 0.833 g/mL at 25 °C(lit.)
vapor density: 7.4 (vs air)
vapor pressure: 0.1 mm Hg ( 20 °C)
refractive index: n20/D 1.442(lit.)
FEMA: 2617 | LAURYL ALCOHOL
Flash point: >230 °F
storage temp.: Store below +30°C.
solubility: water: slightly soluble1g/L at 23°C
form: Liquid
pka: 15.20±0.10(Predicted)
color: APHA: ≤10
Odor: Typical fatty alcohol odor; sweet.
Odor Type: waxy
Viscosity: 11.251mm2/s
explosive limit 4%
Water Solubility: insoluble
Merck: 14,3405
JECFA Number: 109
BRN: 1738860
InChIKey: LQZZUXJYWNFBMV-UHFFFAOYSA-N
LogP: 5.4 at 23℃

In 1993, the European demand of dodecanol was around 60,000 tonnes per year.
Dodecanol can be obtained from palm kernel or coconut oil fatty acids and methyl esters by hydrogenation.
Dodecanol may also be produced synthetically via the Ziegler process.

A classic laboratory method involves Bouveault-Blanc reduction of ethyl laurate.
Dodecanol is used to make surfactants, lubricating oils, pharmaceuticals, in the formation of monolithic polymers and as a flavor enhancing food additive.
In cosmetics, dodecanol is used as an emollient.

Dodecanol is also the precursor to dodecanal, an important fragrance, and 1-bromododecane, an alkylating agent for improving the lipophilicity of organic molecules.
Dodecanol is an alcohol.
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents.

They react with oxoacids and carboxylic acids to form esters plus water.
Oxidizing agents convert them to aldehydes or ketones.
Alcohols exhibit both weak acid and weak base behavior.

They may initiate the polymerization of isocyanates and epoxides.
Dodecanol is a saturated 12-carbon fatty alcohol obtained from coconut oil fatty acids.
Dodecanol has a floral odor and is used in detergents, lubricating oils, and pharmaceuticals.

Dodecanol, also known by its IUPAC name 1-dodecanol or dodecan-1-ol, and by its trivial name dodecyl alcohol and lauryl alcohol, is a fatty alcohol.
Dodecanol is a colourless, water insoluble solid with a melting point of 24 °C and boiling point of 259 °C.
Dodecanol has a floral odor.

Dodecanol can be obtained from palm kernel or coconut oil fatty acids and methyl esters by reduction.
Dodecanol belongs to a broad range of flavor and fragrance standards, used for the quality control of food and cosmetic products.
Dodecanol is identified as the main component in Etlingera elatior flower, widely used in traditional medicine and as a flavoring compound in food products, essential oils of Hypericum perforatum and Polygonum minus.

Dodecanol is the most studied C12 alcohol and finds extensive usage as a diluent/solvent/blender in low-cost perfumes, detergent fragrances, etc.
Dodecanol is valued for its surfactant properties.
As a surfactant, Dodecanol can reduce the surface tension between two immiscible substances, such as oil and water.

This makes it useful in products like emulsions, where it helps stabilize and evenly distribute two substances that would typically separate, such as oil and water in salad dressings or creams.
Dodecanol is often used in cosmetics and personal care products as an emollient. Emollients are substances that help moisturize and soften the skin.
Dodecanol can create a protective barrier on the skin's surface, helping to prevent moisture loss and keep the skin hydrated.

In the pharmaceutical industry, dodecanol can be employed as an excipient or a component in drug formulations.
Dodecanol can serve various functions, including as a solubilizing agent, binder, or viscosity modifier in certain medications and topical products.
Dodecanol may find applications in the food industry, particularly in food processing.

Dodecanol can be used as a lubricant in food machinery to reduce friction and improve processing efficiency.
Due to its ability to dissolve various substances and its surfactant properties, dodecanol can be found in some industrial cleaning products, especially those designed to remove grease and oil.
Dodecanol is used as a component in some flame retardant formulations.

Dodecanols inclusion can help reduce the flammability of materials like textiles and plastics.
Dodecanol is considered to be relatively biodegradable under certain conditions, which is important for environmental considerations when it is used in various products.
However, the biodegradability of any specific formulation or product that contains dodecanol can vary depending on the overall composition and other factors.

Dodecanol is often found in various household products.
Dodecanol can be an ingredient in laundry detergents, fabric softeners, and dishwashing detergents, where it helps to remove stains and grease from fabrics and dishes.
In the textile industry, dodecanol can be used as an auxiliary agent in the dyeing process.

Dodecanol helps to disperse dyes evenly and improve their absorption by the fabric.
Dodecanol can function as a foaming agent in certain applications.
For example, Dodecanol can be used to create stable foam in fire extinguishing foam concentrates.

In the fragrance industry, dodecanol can be used as a fixative, helping to extend the longevity of fragrances by slowing down their evaporation rate.
Dodecanol is utilized in metalworking fluids as a lubricant and corrosion inhibitor.
Dodecanol can help improve the performance of cutting fluids used in machining operations.

Dodecanol can serve as a thickening agent in various formulations, including creams, lotions, and ointments.
Dodecanol helps to give these products a desirable texture and consistency.
Dodecanol can be used as a starting material or intermediate in the synthesis of other chemicals.

Dodecanol can undergo various chemical reactions to produce derivatives with different properties and applications.
Dodecanol is sometimes used in scientific research and laboratory settings for various experimental purposes, particularly in studies related to surfactants, emulsions, and colloid chemistry.

While dodecanol is generally considered safe for many applications, it's essential to note that, like other alcohols, it can have biological effects when ingested or applied to the skin.
Ingesting dodecanol can lead to alcohol intoxication, and contact with the skin or eyes can cause irritation in some individuals.

Dodecanol can act as a plasticizer or a component in plastic formulations.
Plasticizers are additives that improve the flexibility, durability, and workability of plastics.
Dodecanol can help make certain types of plastics more pliable and easier to process.

In the paper and pulp industry, dodecanol can be used as a debubbling agent, helping to eliminate foam during various papermaking processes.
Dodecanol aids in maintaining the smoothness and quality of paper products.

Dodecanol can be used as a coalescing agent in paint and coating formulations.
Coalescing agents help paint particles come together and form a continuous film when applied to a surface, improving the overall quality of the finish.
Dodecanol is utilized in various chemical reactions and synthesis processes.

Dodecanols long hydrocarbon chain and functional group make it a valuable starting material for the production of other chemicals, including fragrances, surfactants, and specialty chemicals.
Dodecanol can find use in drilling fluids and lubricants.
It can assist in reducing friction and improving the performance of drilling operations.

Dodecanol can be employed as a foam stabilizer in a range of applications, such as in the production of foamed plastics and as an ingredient in firefighting foam formulations.
In mineral processing, dodecanol may be used as a flotation reagent to aid in separating valuable minerals from gangue minerals by selectively promoting the attachment of certain particles to air bubbles.
Dodecanol can act as a preservative in some pharmaceutical and cosmetic formulations, helping to extend the shelf life of these products by inhibiting the growth of microorganisms.

Uses
Dodecanol is used as a cosmetic, textile auxiliaries, synthetic oil, emulsifiers and flotation agent of raw materials, a detergent raw material, a foaming agent of the toothpaste.
Dodecanol is used in chemical formulations for a variety of purposes, including as an emulsion stabilizer, a skin-conditioning emollient, and a viscosity-increasing agent.
Dodecanol may be used as an analytical reference standard for the quantification of the analyte in:Etlingera elatior flower using gas chromatography-mass spectroscopy (GC-MS).

Essential oils from the aerial parts of Hypericum perforatum by gas chromatography (GC) and gas chromatography coupled to mass spectrometry (GC-MS).Essential oils from Polygonum minus by gas chromatography coupled to mass spectrometry (GC-MS) and GC-MS/olfactometry (GC-MS/O) with aroma extraction dilution analysis (AEDA).
Dodecanol is commonly used in cosmetics and personal care products, such as creams, lotions, shampoos, and conditioners.
Dodecanol acts as an emollient, helping to soften and moisturize the skin and hair.

Dodecanol also assists in stabilizing emulsions and ensuring even product distribution.
Dodecanol is used as a surfactant or emulsifying agent in various products.
Dodecanol helps mix water and oil-based ingredients, making it a key component in formulations for detergents, soaps, and other cleaning products.

In the pharmaceutical industry, dodecanol can serve as an excipient or an ingredient in drug formulations.
Dodecanol can help solubilize certain drugs and improve the texture of pharmaceutical preparations.
Dodecanol is used as a component in the formulation of flavors and fragrances.

Dodecanol can act as a carrier for essential oils and aroma compounds, helping to disperse and stabilize them.
Dodecanol can function as a plasticizer, which improves the flexibility and workability of plastics and polymers.
Dodecanol is used in the production of certain plastic materials.

Dodecanol has applications in various industrial processes, including metalworking fluids, where it acts as a lubricant and corrosion inhibitor.
Dodecanol can also be found in cutting fluids used in machining operations.
While not a direct food additive, dodecanol can find use in the food industry as a lubricant for food processing machinery.

Dodecanol helps reduce friction during food manufacturing processes.
Dodecanol can be used as a foaming agent in products like fire extinguishing foam concentrates and foamed plastics.
In the textile industry, dodecanol is used as an auxiliary agent during the dyeing process to disperse dyes and improve their absorption by fabrics.

Dodecanol can serve as a debubbling agent in papermaking processes, helping to eliminate foam and maintain paper quality.
Dodecanol is used as a starting material or intermediate in the synthesis of various chemicals, including surfactants, fragrances, and specialty chemicals.
In mineral processing, dodecanol can be employed as a flotation reagent to assist in the separation of valuable minerals from gangue minerals.

Dodecanol is used as a foam stabilizer in the production of foamed plastics and in the formulation of firefighting foams.
Dodecanol is often included in cleaning products such as household cleaners, industrial degreasers, and dishwashing detergents due to its surfactant properties.
Dodecanol helps dissolve and remove grease, oil, and dirt from various surfaces.

Dodecanol can be used in the formulation of inks, varnishes, and coatings, where it acts as a coalescing agent.
Dodecanol promotes the uniform dispersion and binding of pigment particles, contributing to the quality of printed materials and coated surfaces.
Dodecanol may be added to adhesive formulations to improve the adhesive's performance and durability.

Dodecanol can enhance the adhesive's ability to bond to various surfaces.
Dodecanol is used in the production of firefighting foam concentrates.
Dodecanol helps create stable foam that can suppress fires more effectively, particularly in situations involving flammable liquids.

In the oil and gas industry, dodecanol is used in drilling fluids as a lubricant and corrosion inhibitor.
Dodecanol helps reduce friction and wear on drilling equipment and protects metal surfaces from corrosion.
Dodecanol can serve as a textile auxiliary agent in processes such as dyeing, printing, and finishing.

Dodecanol helps improve the performance and appearance of textiles.
In the food packaging industry, dodecanol can be found in coatings used to enhance the moisture resistance and shelf life of certain food products.
Dodecanol is used as a processing aid and plasticizer in the rubber industry.

Dodecanol improves the workability of rubber compounds during manufacturing.
Dodecanol is used in the production of firelighters or fire starters due to its flammable properties.
When combined with other combustible materials, it can facilitate the ignition of fires.

In some applications, dodecanol can be used as an antifoaming agent to control and reduce foam formation, especially in industrial processes where excessive foam can be problematic.
Dodecanol can be used as a component in metal coating formulations to enhance adhesion and durability.
Dodecanol may find use in the petroleum industry as a component in drilling muds and completion fluids.

In the electronics industry, dodecanol can be used as a processing aid and lubricant during the manufacture of electronic components and circuit boards.
Dodecanol can be employed as a flotation collector in the mining industry to facilitate the separation of valuable minerals from gangue materials in the flotation process.
In the construction industry, dodecanol can be used in the production of construction materials like adhesives, sealants, and caulks, where it helps improve adhesion and workability.

Dodecanol may be utilized in wood preservation treatments to protect wood from decay, insects, and other environmental factors.
In the rubber processing industry, dodecanol can be used to facilitate the mixing and dispersion of rubber compounds, enhancing the overall quality of rubber products.
Dodecanol can be included in water treatment chemicals, such as defoamers and flocculants, to assist in the removal of impurities and contaminants from water.

Dodecanol can serve as a solvent or co-solvent in various chemical reactions, particularly those involving organic synthesis and the production of specialty chemicals.
Dodecanol may find application in the leather industry, where it can be used as a processing aid or lubricant during leather tanning and finishing processes.
In the production of concrete, dodecanol can be used as a plasticizer or superplasticizer to improve the workability and strength of concrete mixes.

Dodecanol can be employed in agriculture as a component in pesticide formulations to enhance the dispersion and effectiveness of active ingredients.
Dodecanol can find use in the oil refining industry as an additive to certain refinery processes to improve efficiency and product quality.
Dodecanol may be used in scientific research and development for various experimental purposes, including studies related to surface chemistry and material science.

Dodecanol can be used as a component in corrosion inhibitor formulations to protect metal surfaces from corrosion in various industrial applications.
Dodecanol can be used as a lubricant in textile machinery to reduce friction and wear during textile manufacturing processes.
In the pyrotechnics industry, dodecanol can be used as a component in firework compositions to control burn rates and create specific visual effects.

Dodecanol can be utilized as a component in metalworking fluids, including cutting fluids and coolants, to improve the lubricating properties and cooling efficiency during machining, grinding, and metal processing operations.
Dodecanol can be used as a propellant in aerosol sprays, helping to disperse the product evenly when it is sprayed from the container.
In the ceramics industry, dodecanol can be employed as a binder and plasticizer in the production of ceramic materials and products, enhancing their plasticity and forming capabilities.

Dodecanol can be used in analytical chemistry techniques such as gas chromatography as a stationary phase for separating and analyzing volatile compounds.
Dodecanol can serve as a fuel additive in some applications to improve the combustion properties and stability of certain fuels.
Dodecanol may find use as an additive in electroplating baths to help improve the quality and uniformity of metal coatings on various substrates.

Dodecanol can be incorporated into sealant and caulk formulations to enhance their adhesion, flexibility, and moisture resistance.
Dodecanol can be used as an additive in lubricating oils and greases to improve their performance and reduce friction in automotive, industrial, and machinery applications.
In the oil and gas industry, dodecanol may be used as an inhibitor to prevent the formation of gas hydrates in pipelines and equipment.

Dodecanol has been used historically in photographic processes as a component of developer solutions and emulsions.
In some applications, dodecanol can exhibit antimicrobial properties and may be included in products designed for disinfection and sanitization.
Dodecanol can be used in certain nuclear applications, such as nuclear reactor coolant additives, where its properties are advantageous for heat transfer and radiation resistance.

Safety Profile
Moderately toxic by intraperitoneal route.
Dodecanol mildly toxic by ingestion.
Dodecanol a severe human skin irritant.

Combustible when exposed to heat or flame; can react with oxidizing materials.
When heated to decomposition it emits acrid smoke and irritating fumes
Dodecanol can cause skin and eye irritation upon direct contact.

Prolonged or repeated exposure to the skin may lead to dryness, redness, or dermatitis.
Protective gloves and safety goggles should be worn when handling dodecanol.
Inhalation of dodecanol vapor or mist may lead to respiratory irritation, including coughing and throat irritation.

Ensure proper ventilation when using or working with dodecanol in enclosed spaces.
Swallowing dodecanol can be harmful.
Dodecanol may lead to gastrointestinal discomfort, nausea, vomiting, and diarrhea.

Flammability:
Dodecanol is flammable, and its vapors can form explosive mixtures in the air.
Store dodecanol in a cool, well-ventilated area away from ignition sources.

Environmental Impact:
Dodecanol can have environmental impacts if released into water bodies or soil.
It may persist in the environment and potentially harm aquatic life. Spills and releases should be promptly reported and managed according to environmental regulations.

Synonyms
1-DODECANOL
Dodecan-1-ol
Dodecanol
Dodecyl alcohol
Lauryl alcohol
112-53-8
n-Dodecyl alcohol
Undecyl carbinol
Dodecylalcohol
Lauric alcohol
Laurinic alcohol
1-Dodecyl alcohol
Pisol
n-Dodecan-1-ol
Duodecyl alcohol
1-Hydroxydodecane
Siponol L5
Karukoru 20
Lauroyl alcohol
Siponol 25
Dodecyl alcoho
Lorol 5
Lorol 7
n-Dodecanol
Lauryl 24
Alcohol C-12
Alfol 12
Lorol 11
Sipol L12
Dytol J-68
Siponol L2
Cachalot L-50
Cachalot L-90
n-Lauryl alcohol
C12 alcohol
Hainol 12SS
Hydroxydodecane
Conol 20P
Conol 20PP
Lorol
EPAL 12
Adol 10
Adol 12
Dodecanol-1
n-Lauryl alcohol, primary
Nacol 12-96
Alcohol C12
Adol 11
FEMA No. 2617
Lorol C 12
NAA 42
CO-1214
FEMA Number 2617
Lipocol L
Dytol J-68 (VAN)
Lorol C 12/98
CO-1214N
CO-1214S
MFCD00004753
CCRIS 662
Dodecanol, 1-
S 1298
MA-1214
Lorol C12
HSDB 1075
NSC 3724
Co-1214S1-dodecanol
EINECS 203-982-0
EPA Pesticide Chemical Code 001509
BRN 1738860
UNII-178A96NLP2
AI3-00309
27342-88-7
DTXSID5026918
CHEBI:28878
178A96NLP2
NSC-3724
EINECS 271-359-0
68551-07-5
EC 203-982-0
Lauryl Alcohol; 1-Dodecanol
4-01-00-01844 (Beilstein Handbook Reference)
DTXCID906918
1DO
CAS-112-53-8
laurylalcohol
Lorol special
Alcohol dodecilo
Alcool laurylique
1-hidroxidodecane
alcohol n-dodecilo
1-alcohol dodecilo
Kalcohl 20
Siponol L 2
Siponol L 5
Dodecan- 1- ol
Philcohol 1200
Alcoholes, c8-18
K 20 (alcohol)
Kalcohl 2098
LAUREX NC
dodecan - 1 - ol
Kalcol 2098
Sipol L 12
DDN (CHRIS Code)
Dodecyl alcohol (8CI)
Conol 1275
LAUREX L1
D0L1YC
1-DODECANOL [MI]
1-Dodecanol, 98.0%
SCHEMBL6844
1-DODECANOL [HSDB]
LAURYL ALCOHOL [FCC]
CHEMBL24722
LAURYL ALCOHOL [FHFI]
LAURYL ALCOHOL [INCI]
C12H25OH
CCRIS 5831
WLN: Q12
Lauryl alcohol, >=98%, FG
NACOL 12-99 ALCOHOL
LAURYL ALCOHOL [USP-RS]
1-dodecanol (ACD/Name 4.0)
1-Dodecanol, analytical standard
ALFOL 1216 CO ALCOHOL
HSDB 5134
NSC3724
12 OH
1-Dodecanol, reagent grade, 98%
BCP29203
CS-D1360
HY-Y0289
Tox21_202124
Tox21_300120
Dodecan-1-ol (Langkettige Alkohole)
LMFA05000001
STL301829
CACHALOT L-90 LAURYL ALCOHOL
Co 12Co-1214Co-1214N
AKOS009031450
C 1214N
DB06894
LS-2878
ALCOHOL C-12 (LAURYL ALCOHOL)
1-Dodecanol, ACS reagent, >=98.0%
NCGC00164341-01
NCGC00164341-02
NCGC00164341-03
NCGC00253987-01
NCGC00259673-01
BP-31213
CS-16955
K 20
1-Dodecanol 100 microg/mL in Acetonitrile
1-Dodecanol, SAJ special grade, >=97.0%
1-Dodecanol, Selectophore(TM), >=98.0%
1-dodecanol; dodecyl alcohol; lauryl alcohol
D0978
FT-0607710
FT-0693265
1-Dodecanol, Vetec(TM) reagent grade, 98%
EN300-20043
C02277
Q161617
Q-200121
Dodecan-1-ol;Dodecyl alcohol;Lauryl alcohol;Dodecanol
Z104476554
Lauryl alcohol, United States Pharmacopeia (USP) Reference Standard

Dodecoic acid is a white, powdery solid with a faint odor of bay oil or soap.
Dodecoic acid, Reagent, also known as Dodecylic acid, is a medium chain fatty acid that has a vague smell of soap and is a powder.
Dodecoic acid is a white crystalline carboxylic acid.


CAS Number: 143-07-7
EC Number: 205-582-1
MDL Number: MFCD00004440
Molecular formula: C10H18O4 / HOOC(CH2)8COOH



SYNONYMS:
Dodecanoic acid, n-Dodecanoic acid, Dodecylic acid, Dodecoic acid, Laurostearic acid, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, C12:0 (Lipid numbers), Laurostearic acid, Laurates, NSC 5026, Vulvic acid, 1-Dodecanoic acid, Dodecanoates, Lauric acid, Dodecylic acid, 1-Undecanecarboxylic acid, FA12:0, n-Dodecanoic acid, lauric acid, n-dodecanoic acid, dodecylic acid, vulvic acid, laurostearic acid, dodecoic acid, duodecylic acid, 1-undecanecarboxylic acid, aliphat no. 4, neo-fat 12, Decanedioic acid, 1,8-Octanedicarboxylic acid, Decane-1,10-dioic acid, sebacic acid, DECANEDIOIC ACID, 111-20-6, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid, Sebacic acids, Sebacinsaure, Decanedicarboxylic acid, n-Decanedioic acid, Acide sebacique, Sebacinsaeure, USAF HC-1, Ipomic acid, Seracic acid, Decanedioic acid, homopolymer, NSC 19492, UNII-97AN39ICTC, 1,8-dicarboxyoctane, 26776-29-4, NSC19492, 97AN39ICTC, octane-1,8-dicarboxylic acid, CHEBI:41865, NSC-19492, DSSTox_CID_6867, DSSTox_RID_78231, DSSTox_GSID_26867, SebacicAcid, CAS-111-20-6, CCRIS 2290, EINECS 203-845-5, BRN 1210591, n-Decanedioate, Iponic acid, AI3-09127, disodium-sebacate, 4-oxodecanedioate, MFCD00004440, 1,10-Decanedioate, Sebacic acid, 94%, Sebacic acid, 99%, Dicarboxylic acid C10, 1i8j, 1l6s, 1l6y, 1,8-Octanedicarboxylate, WLN: QV8VQ, SEBACIC ACID, EC 203-845-5, SCHEMBL3977, NCIOpen2_008624, SEBACIC ACID, 4-02-00-02078, SEBACIC ACID, CHEMBL1232164, DTXSID7026867, Sebacic acid, >=95.0% (GC), ZINC1531045, Tox21_201778, Tox21_303263, BBL011473, LMFA01170006, s5732, STL146585, AKOS000120056, CCG-266598, CS-W015503, DB07645, GS-6713, HY-W014787, NCGC00164361-01, NCGC00164361-02, NCGC00164361-03, NCGC00257150-01, NCGC00259327-01, BP-27864, NCI60_001628, DB-121158, FT-0696757, C08277, A894762, C10-120, C10-140, C10-180, C10-220, C10-260, C10-298, Q413454, Q-201703, Z1259273339, 301CFA7E-7155-4D51-BD2F-EB921428B436, 1,8-Octanedicarboxylic acid, Decanedioic acid, Octane-1,8-dicarboxylic acid, 1,10-Decanedioic Acid, 1,8-Octanedicarboxylic Acid, NSC 19492, NSC 97405, n-Decanedioic Acid, 1,10-Decanedioate, 1,10-Decanedioic acid, 1,8-Dicarboxyoctane, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4,7-dioxosebacic acid, 4-Oxodecanedioate, 4-oxodecanedioate, 4-Oxodecanedioic acid, 1,10-Decanedioic acid, 1,8-Dicarboxyoctane, Decanedioic acid, Sebacinsaeure, 1,10-Decanedioate, Decanedioate, Sebacate, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4-Oxodecanedioate, 4-Oxodecanedioic acid, Acide sebacique, Decanedicarboxylic acid, Dicarboxylic acid C10, Ipomic acid, N-Decanedioate, N-Decanedioic acid, Sebacic acids, Sebacinsaure, Seracic acid, Sebacic acid, aluminum salt, Sebacic acid, monocadmium salt, Sebacic acid, sodium salt, DECANEDIOIC ACID, sebacic, USAF hc-1, acidesebacique, SEBACIC ACID pure, n-Decanedioic acid, 1,10-Decanedioic acid, Decanedicarboxylic acid, sebacate (decanedioate), 1,8-OCTANEDICARBOXYLIC ACID, 1,10-Decanedioate, 1,10-Decanedioic acid, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4-Oxodecanedioate, 4-Oxodecanedioic acid, Acide sebacique, Decanedicarboxylic acid, Decanedioate, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid, n-Decanedioic acid, 4-Oxodecanedioate, 1,8-Dicarboxyoctane, Octane-1,8-dicarboxylic acid, Sebacic acid, Ipomic acid, Seracic acid, lauric acid, DODECANOIC ACID, 143-07-7, n-Dodecanoic acid, Dodecylic acid, Laurostearic acid, Vulvic acid, Dodecoic acid, Duodecylic acid, 1-Undecanecarboxylic acid, Aliphat No. 4, Ninol AA62 Extra, Wecoline 1295, Hydrofol acid 1255, Hydrofol acid 1295, Duodecyclic acid, Hystrene 9512, Univol U-314, Lauric acid, pure, Dodecylcarboxylate, Lauric acid (natural), Laurinsaeure, Undecane-1-carboxylic acid, ABL, NSC-5026, FEMA No. 2614, laurate, C-1297, Philacid 1200, CCRIS 669, C12:0, Emery 651, Lunac L 70, CHEBI:30805, HSDB 6814, EINECS 205-582-1, UNII-1160N9NU9U, BRN 1099477, n-Dodecanoate, Kortacid 1299, Dodecanoic Acid Anion, DTXSID5021590, Prifrac 2920, AI3-00112, Lunac L 98, Univol U 314, Prifac 2920, 1160N9NU9U, MFCD00002736, DAO, DTXCID801590, CH3-[CH2]10-COOH, NSC5026, EC 205-582-1, dodecylate, laurostearate, vulvate, 4-02-00-01082 (Beilstein Handbook Reference), DODECANOIC ACID (LAURIC ACID), 1-undecanecarboxylate, LAURIC ACID (USP-RS), LAURIC ACID [USP-RS], CH3-(CH2)10-COOH, 8000-62-2, CAS-143-07-7, SMR001253907, laurinsaure, dodecanic acid, Nuvail, lauric-acid, Acide Laurique, 3uil, Lauric acid (NF), DODECANOICACID, fatty acid 12:0, Lauric Acid, Reagent, Nissan NAA 122, Emery 650, Dodecanoic acid, 98%, Dodecanoic acid, 99%, Guaranteed Reagent,99%, Dodecanoic (Lauric) acid, LAURIC ACID [MI], bmse000509, LAURIC ACID [FCC], LAURIC ACID [FHFI], SCHEMBL5895, NCIOpen2_009480, MLS002177807, MLS002415737, WLN: QV11, Dodecanoic acid (lauric acid), LAURIC ACID [WHO-DD], Dodecanoic acid, >=99.5%, Edenor C 1298-100, DODECANOIC ACID [HSDB], CHEMBL108766, GTPL5534, NAA 122, NAA 312, HMS2268C14, HMS3649N06, HY-Y0366, STR08039, Dodecanoic acid, analytical standard, Lauric acid, >=98%, FCC, FG, Tox21_202149, Tox21_303010, BDBM50180948, LMFA01010012, s4726, STL281860, AKOS000277433, CCG-266587, DB03017, FA 12:0, HYDROFOL ACID 1255 OR 1295, NCGC00090919-01, NCGC00090919-02, NCGC00090919-03, NCGC00256486-01, NCGC00259698-01, AC-16451, BP-27913, DA-64879, Dodecanoic acid, >=99% (GC/titration), LAU, Dodecanoic acid, purum, >=96.0% (GC), Lauric acid, natural, >=98%, FCC, FG, CS-0015078, L0011, NS00008441, EN300-19951, C02679, D10714, A808010, LAURIC ACID (CONSTITUENT OF SAW PALMETTO), Q422627, SR-01000838338, J-007739, SR-01000838338-3, BRD-K67375056-001-07-9, F0001-0507, LAURIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC], Z104476194, 76C2A2EB-E8BA-40A6-8032-40A98625ED7B, Lauric acid, European Pharmacopoeia (EP) Reference Standard, Lauric acid, United States Pharmacopeia (USP) Reference Standard, Lauric Acid, Pharmaceutical Secondary Standard; Certified Reference Material, 203714-07-2, 7632-48-6, InChI=1/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14, 1-Undecanecarboxylate, 1-Undecanecarboxylic acid, ABL, Acide Laurique, C12 fatty acid, C12:0, Coconut oil fatty acids, DAO, Dodecanoate, dodecanoic acid, dodecoate, Dodecoic acid, Dodecylate, dodecylcarboxylate, Dodecylic acid, duodecyclate, Duodecyclic acid, duodecylate, Duodecylic acid, LAP, LAU, Laurate, Lauric acid, Laurinsaeure, Laurostearate, Laurostearic acid, MYR, n-Dodecanoate, n-Dodecanoic acid, Sorbitan laurate, Sorbitan monolaurate (NF), undecane-1-carboxylate, Undecane-1-carboxylic acid, Vulvate, Vulvic acid, CH3-[CH2]10-COOH, Dodecylcarboxylic acid, Laate, Laic acid, Aliphat no. 4, Edenor C 1298-100, Emery 651, Hystrene 9512, Kortacid 1299, Lunac L 70, Lunac L 98, Neo-fat 12, Neo-fat 12-43, Nissan naa 122, Philacid 1200, Prifac 2920, Univol u 314, 1-Dodecanoic acid, FA(12:0), 1-Undecanecarboxylic acid, ABL, Aliphat no. 4, C12 fatty acid, Coconut oil fatty acids, Dodecanoate, Dodecanoic (lauric) acid, Dodecanoic acid (lauric acid), Dodecoic acid, Dodecylcarboxylate, Dodecylic acid, Duodecyclic acid, Duodecylic acid, Emery 650, Lauric acid, Lauric acid, pure, Laurinsaeure, Laurostearic acid, Lunac L 70, n-Dodecanoic Acid, N-Dodecanoate, Neo-fat 12, Ninol aa62 extra, Undecane-1-carboxylic acid, Univol U 314, Univol U-314, Vulvic acid, AI3-00112, BRN 1099477, C-1297, CCRIS 669, EINECS 205-582-1, FEMA NO. 2614, HSDB 6814, HYDROFOL ACID 1255, HYDROFOL ACID 1295, HYSTRENE 9512, NEO-FAT 12-43, PHILACID 1200, PRIFRAC 2920, WECOLINE 1295, 1-Undecanecarboxylic acid, ABL, AC-16451, AC1L1GY2, AC1Q5W8C, AKOS000277433, Aliphat No. 4, CH3-[CH2]10-COOH, Coconut oil fatty acids, DAO, DODECANOIC ACID, DODECANOIC ACID (LAURIC ACID), Dodecanoate, Dodecanoic (Lauric) acid, Dodecanoic acid (lauric acid), Dodecanoic acid(Lauric acid), Dodecoic acid, Dodecylcarboxylate, Dodecylic acid, Duodecyclic acid, Duodecylic acid, Emery 650, Hydrofol acid 1255, Hydrofol acid 1295, Hystrene 9512, I04-1205, L-ALFA-LYSOPHOSPHATIDYLCHOLINE, LAUROYL, L0011, LAP, LAU, Lauric acid, pure, Laurinsaeure, Laurostearic acid, Lunac L 70, Neo-fat 12, Neo-fat 12-43, Ninol AA62 Extra, Philacid 1200, Prifrac 2920, SMR001253907, ST023796, Undecane-1-carboxylic acid, Univol U-314, Vulvic acid, Wecoline 1295, [2-((1-OXODODECANOXY-(2-HYDROXY-3-PROPANYL))-PHOSPHONATE-OXY)-ETHYL]-TRIMETHYLAMMONIUM, n-Dodecanoate, n-Dodecanoic acid, nchembio.364-comp10, Dodecanoic acid, n-Dodecanoic acid, Neo-fat 12, Aliphat no. 4, Abl, Dodecylic acid, Lauric acid, Laurostearic acid, Neo-fat 12-43, Ninol aa62 extra, Univol u-314, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, C-1297, Coconut oil fatty acids, Hydrofol acid 1255, Hydrofol acid 1295, Wecoline 1295, Dodecoic acid, Hystrene 9512, Lunac L 70, Duodecyclic acid, Emery 650, n-Dodecanoate, Philacid 1200, Prifrac 2920, Undecane-1-carboxylic acid, C-1297, dodecanoic acid, dodecoic acid, duodecylic acid, ndodecanoic acid, Hydrofol acid 1255, Hydrofol acid 1295, Hystrene 9512, laurostearic acid, Neo-fat 12, Neo-fat 12-43, Ninol AA62 Extra, 1-undecanecarboxylic acid, vulvic acid, Wecoline 1295, Dodecoic acid, Duodecyclic acid, Edenor C 1298-100, Emery 650, Hydrofol acid 1295, Hystrene 9512, Kortacid 1299, Laurostearate, Lunac L 70, Lunac L 98, Neo-fat 12, Ninol AA62 extra, Nissan naa 122, Philacid 1200, Prifac 2920, Prifrac 2920, Univol U 314, Vulvate, Vulvic acid, Wecoline 1295, 1-Undecanecarboxylate, 1-Undecanecarboxylic acid, Dodecylate, Dodecylcarboxylate, Dodecylic acid, Duodecylic acid, Laurostearic acid, n-Dodecanoic acid, Undecane-1-carboxylic acid, LAP, LAU, DAO, lauric acid, n-dodecanoic acid, dodecylic acid, vulvic acid, laurostearic acid, dodecoic acid, duodecylic acid, 1-undecanecarboxylic acid, aliphat no. 4, neo-fat 12, 143-07-7, 205-582-1, 1-UNDECANECARBOXYLIC ACID, DODECANOIC ACID, DODECANOIC ACID [HSDB], DODECOIC ACID, FEMA NO. 2614, LAURATE, LAURIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC], LAURIC ACID [FCC], LAURIC ACID [FHFI], LAURIC ACID [MI], LAURIC ACID [USP-RS], LAURIC ACID [WHO-DD], LAUROSTEARIC ACID, N-DODECANOIC ACID, NSC-5026, Dodecanoic acid, Lauric acid, Laurostearic acid, 1-Undecanecarboxylic acid, ABL, Aliphat No. 4, Univol U 314, Dodecylic acid, Vulvic acid, Neo-Fat 12-43, n-Dodecanoic acid, Neo-Fat 12, Lunac L 70, Emery 651, Prifac 2920, Nissan NAA 122, Lunac L 98, Hystrene 9512, NAA 312, Kortacid 1299, Philacid 1200, Edenor C 1298-100, NSC 5026, NAA 122, Prifac 2922, Edenor C 12, Prifrac 2920, ContraZeck, 1-Dodecanoic acid, Imex C 1299, Palmac 98-12, Edenor 12/98-100, Palmera B 1231, Edenor C 12-98-100, Lasacid FC 12, Laurates, Dodecanoates, Palmae 99-12, D 97385, Edenor C12-99, Coconut Hard 34, Coconut Hard 42, Radiacid 0624, NS 6, 7632-48-6, 8000-62-2, 8045-27-0, 203714-07-2, 55621-34-6, DODECANOIC ACID, C12, Emery651, Vulvic acid, FEMA 2614, lauric acid, pure, N-DODECANOIC ACID, LAUROSTEARIC ACID, Lauric acid 98-101 % (acidimetric), Fatty acid methyl ester sulfonate (MES), Dodecanoic D23 Acid, Dodecanoic Acid-d23,1-Dodecanoic Acid-d23, 1-Undecanecarboxylic Acid-d23, ABL-d23, Aliphat No. 4-d23, ContraZeck-d23, Dodecylic Acid-d23, Edenor C 12-d23,Edenor C 1298-100-d23, Emery 651-d23, Hystrene 9512-d23, Imex C 1299-d23, Kortacid 1299-d23, Laurostearic Acid-d23, Lunac L 70-d23, Lunac L 98-d23, NAA 122-d23, NAA 312-d23, NSC 5026-d23, Neo-Fat 12-d23, Neo-Fat 12-43-d23, Nissan NAA 122-d23, Philacid 1200-d23, Prifac 2920-d23, Prifac 2922-d23, Prifrac 2920-d23, Univol U 314-d23, Vulvic Acid-d23, n-Dodecanoic Acid-d23, Dodecanoate, Coconut Oil Fatty Acids, Laurostearic Acid, N-Dodecanoic Acid, C12 Fatty Acid, Duodecyclic Acid, Vulvic Acid, Dodecanoic Acid (Lauric Acid), Duodecylic Acid, N-Dodecanoate, Dodecanoic (Lauric) Acid, Laurinsaeure, Lauric Acid, Pure, Lauric Acid (Natural), Dodecylcarboxylate, Abl, Dao, Lap, Lau, Myr



Dodecoic acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
Dodecoic acid is a conjugate acid of a dodecanoate.
Dodecoic acid derives from a hydride of a dodecane.


Dodecoic acid is a white crystalline carboxylic acid.
Dodecoic acid is used as a plasticizer and for making detergents and soaps.
Dodecoic acid's glycerides occur naturally in coconut and palm oils.


Dodecoic acid is a white solid with a slight odor of bay oil.
Dodecoic acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.


Dodecoic acid is a white, powdery solid with a faint odour of mild fatty coconut bay oil or soap.
Dodecoic acid is the main fatty acid in coconut oil (49%) and in palm kernel oil (47-50%), and is found in lesser amounts in wild nutmeg, human breast milk, cow’s milk, goat milk, watermelon seeds, plum and macadamia nut.


Dodecoic acid, although slightly irritating to mucous membranes, has an extremely low toxicity, is inexpensive, has antimicrobial properties and so is used in many soaps and shampoos.
Dodecoic acid is a weakly acidic compound.


Dodecoic acid is reacted with sodium hydroxide to generate sodium laurate, which is soap.
Dodecoic acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid either saturated or unsaturated"


Dodecoic acid is a saturated fatty acid with the structural formula CH3(CH2)10COOH .
Dodecoic acid is the main acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
Dodecoic acid is also found in human milk(5.8% of total fat), cows milk(2.2%), and goat milk(4.5%).


Dodecoic acid is a white, powdery solid with a faint odor of bay oil or soap.
Dodecoic acid, Reagent, also known as Dodecoic acid, is a medium chain fatty acid that has a vague smell of soap and is a powder.
Dodecoic acid is found naturally in human breast milk as well as cow's and goat's milk.


Dodecoic acid's reagent grade means this is the highest quality commercially available for this chemical and that the American Chemical Society has not officially set any specifications for this material.
Dodecoic acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.


Additionally, Dodecoic acid is employed in food science research where it serves as a model to understand the digestion and metabolism of medium-chain fatty acids.
Dodecoic acid's antimicrobial properties are also examined in terms of how they can be leveraged in non-medical applications, such as in food preservation and safety, where reducing microbial growth is essential.


Moreover, Dodecoic acid′s role in industrial applications extends to its use as a raw material in the synthesis of various chemical derivatives, including esters used in flavorings and fragrances, showcasing its versatility and importance in both scientific research and industrial applications.
Dodecoic acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


Dodecoic acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
Dodecoic acid, C12H24O2, also known as Dodecoic acid, is a saturated fatty acid with a 12-carbon atom chain.
The powdery, white crystalline acid, Dodecoic acid, has a slight odor of oil of bay and occurs naturally in various plant and animal fats and oils.


Dodecoic acid is a major component of coconut oil and palm kernel oil.
Dodecoic acid, CAS 143-07-7, chemical formula C12H24O2, is produced as a white crystalline powder, has a slight odor of bay oil, and is soluble in water, alcohols, phenyls, haloalkanes, and acetates.


Dodecoic acid is non-toxic, safe to handle, inexpensive, and has a long shelf life.
Dodecoic acid is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids.
Dodecoic acid is a white, powdery solid with a faint odor of bay oil or soap.


Dodecoic acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
Dodecoic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


Dodecoic acid is a potentially toxic compound.
Dodecoic acid has the chemical formula C12H24O2.
Dodecoic acid appears as a white crystalline solid with a characteristic odor like oil of bay.


Dodecoic acid is insoluble in Water and soluble in Ether, Chloroform, and Alcohol.
Dodecoic acid is found naturally in some plant and animal fats and is a key component of coconut oil.
Dodecoic acid is synthetically prepared by the fractional distillation of other acids of mixed coconut.


Dodecoic acid is a solid at room temperature but melts easily in boiling water, so liquid Dodecoic acid can be treated with various solutes and used to determine their molecular masses.
Dodecoic acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.


Dodecoic acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Dodecoic acid are known as laurates.
Dodecoic acid is a saturated fatty acid with a terminal carboxylic acid.


The terminal carboxylic acid, Dodecoic acid, can react with primary amine groups in the presence of activators such as HATU.
Dodecoic acid is a carbon 13 labeled form of a saturated fatty acid found in coconut milk, coconut oil, laurel oil, and palm kernel oil, as well as in human breast milk and other animal milks.


Dodecoic acid is a proton pump inhibitor potentially for the treatment of helicobacter pylori infections.
In vitro experiments have suggested that some fatty acids including Dodecoic acid could be a useful component in a treatment for acne, but no clinical trials have yet been conducted to evaluate this potential benefit in humans.


Dodecoic acid increases total serum cholesterol more than many other fatty acids.
But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol).
As a result, Dodecoic acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid, either saturated or unsaturated.


Dodecoic acid, identified by CAS number 143-07-7, is a saturated medium-chain fatty acid with a 12-carbon atom backbone, prominently known for its role in the manufacturing of soaps, detergents, and cosmetics.
As a fundamental component, Dodecoic acid is celebrated for its surfactant properties, which enable the production of a rich lather in cleansing products.


In research, Dodecoic acid is extensively used to study lipid behavior in various systems due to its amphiphilic nature, which allows it to assemble into micelles and other nanostructures in aqueous solutions.
These studies are crucial for advancing the fields of material science and nanotechnology, particularly in the development of delivery systems and the enhancement of product formulations.


Dodecoic acid is a white solid with a slight odor of bay oil.
Dodecoic acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.


Dodecoic acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.
Dodecoic acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
Dodecoic acid is a conjugate acid of a dodecanoate.


Dodecoic acid derives from a hydride of a dodecane.
Dodecoic acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.
Dodecoic acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.


Dodecoic acid is a metabolite found in or produced by Escherichia coli.
Dodecoic acid is a natural product found in Ipomoea leptophylla, Arisaema tortuosum, and other organisms with data available.
Dodecoic acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


Dodecoic acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
Dodecoic acid is the main fatty acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
Dodecoic acid is a white, powdery solid with a faint odor of bay oil.


Dodecoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.
Dodecoic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
Dodecoic acid is a medium-chain saturated fatty acid.


Dodecoic acid is found in many vegetable fats and in coconut and palm kernel oils.
Dodecoic acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Dodecoic acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.
Dodecoic acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Dodecoic acid are known as laurates.


Dodecoic acid is a precursor to dilauroyl peroxide, a common initiator of polymerizations.
Dodecoic acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.


Dodecoic acid, also known as dodecanoate or lauric acid, belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
Dodecoic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


Dodecoic acid is the main fatty acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
Dodecoic acid is a white, powdery solid with a faint odour of bay oil.
Dodecoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.


Dodecoic acid is a fatty acid that has been shown to inhibit the growth of bacteria.
Dodecoic acid inhibits bacterial growth by binding to the active site of the enzyme dihydrolipoamide acetyltransferase, which catalyzes the conversion of dihydrolipoamide and acetyl-CoA to succinyl-CoA and acetoacetyl-CoA.


Dodecoic acid also binds to dinucleotide phosphate, which is involved in regulation of phase transition temperature and biological samples.
Dodecoic acid has also been shown to act as an active inhibitor of fatty acid synthase, an enzyme that catalyzes the synthesis of fatty acids from acetyl-coenzyme A (acetyl-CoA).


This process is essential for bacterial growth.
Dodecoic acid has synergistic effects with other antibiotics such as ampicillin, erythromycin, and tetracycline.
Dodecoic acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


Dodecoic acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
Dodecoic acid is a medium-length long-chain fatty acid, or lipid, that makes up about half of the fatty acids within coconut oil.
Dodecoic acid’s a powerful substance that is sometimes extracted from the coconut for use in developing monolaurin.


Monolaurin is an antimicrobial agent that is able to fight bacteria, viruses, yeasts, and other pathogens.
Because you can’t ingest Dodecoic acid alone (it’s irritating and not found alone in nature), you’re most likely to get it in the form of coconut oil or from fresh coconuts.


Though coconut oil is being studied at a breakneck pace, much of the research doesn’t pinpoint what in the oil is responsible for its reported benefits.
Because coconut oil contains much more than just Dodecoic acid, it would be a stretch to credit it with all of the coconut oil benefits.
Still, a 2015 analysis suggests that many of the benefits tied to coconut oil are directly linked to Dodecoic acid.


Among the benefits, they suggest Dodecoic acid could aid weight loss and even protect against Alzheimer’s disease.
Its effects on blood cholesterol levels still need to be clarified.
This research suggests that the benefits of Dodecoic acid are due to how the body uses it.


The majority of Dodecoic acid is sent directly to the liver, where it’s converted to energy rather than stored as fat.
When compared with other saturated fats, Dodecoic acid contributes the least to fat storage.
Dodecoic acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.


Dodecoic acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Dodecoic acid are known as laurates.
Like many other fatty acids, Dodecoic acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.


Dodecoic acid is mainly used for the production of soaps and cosmetics.
For these purposes, Dodecoic acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.


These precursors give mixtures of sodium laurate and other soaps. Dodecoic acid occurs as a white crystalline powder
Dodecoic acid is a saturated fatty acid with a 12-carbon atom chain used in industrial cleaners, lubricants, soaps, surfactants, agricultural additives, coatings, food additives, textile additives.


Dodecoic acid, the saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white, powdery solid with a faint odor of bay oil or soap.
Dodecoic acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil.


Otherwise Dodecoic acid is relatively uncommon.
Dodecoic acid increases total serum cholesterol the most of any fatty acid.
But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol).


As a result, Dodecoic acid has been characterized as having "a more favorable effect on total:HDL cholesterol than any other fatty acid, either saturated or unsaturated."
In general, a lower total/HDL serum cholesterol ratio correlates with a decrease in atherosclerotic risk.


For these purposes, Dodecoic acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Dodecoic acid is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids.
Dodecoic acid is a white crystalline carboxylic acid with a faint odor of bay oil or soap.


Dodecoic acid has been found at high levels in coconut oil.
Dodecoic acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.


Dodecoic acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.
Dodecoic acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.



USES and APPLICATIONS of DODECOIC ACID:
Dodecoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.
Dodecoic acid is also used as a food additive and an active component in a treatment for acne.


In addition to this, Dodecoic acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.


In addition to this, Dodecoic acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecoic acid is used in the following products: washing & cleaning products, polishes and waxes, adhesives and sealants, cosmetics and personal care products and laboratory chemicals.


Dodecoic acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Dodecoic acid is used for the manufacture of: textile, leather or fur.


Dodecoic acid is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Dodecoic acid is approved for use as a biocide in the EEA and/or Switzerland, for: repelling or attracting pests.


People also use Dodecoic acid as medicine.
People use Dodecoic acid for viral infections such as the flu, common cold, genital herpes, and many other conditions, but there is no good scientific evidence to support any use.


Dodecoic acid is used in the following products: washing & cleaning products, coating products, fillers, putties, plasters, modelling clay, finger paints, polishes and waxes, air care products and plant protection products.
Other release to the environment of Dodecoic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


Release to the environment of Dodecoic acid can occur from industrial use: industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting) and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).


Other release to the environment of Dodecoic acid is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


Dodecoic acid can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
Dodecoic acid is also used as a food additive and an active component in a treatment for acne.


Dodecoic acid can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), leather (e.g. gloves, shoes, purses, furniture) and paper used for packaging (excluding food packaging).


Release to the environment of Dodecoic acid can occur from industrial use: formulation of mixtures and in processing aids at industrial sites.
Other release to the environment of Dodecoic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


Dodecoic acid is used in the following products: polymers, pH regulators and water treatment products, leather treatment products, coating products, fillers, putties, plasters, modelling clay, finger paints, inks and toners, cosmetics and personal care products, lubricants and greases and textile treatment products and dyes.


Release to the environment of Dodecoic acid can occur from industrial use: formulation of mixtures and formulation in materials.
Dodecoic acid is used in the following products: washing & cleaning products, leather treatment products, polymers, textile treatment products and dyes, pH regulators and water treatment products and lubricants and greases.


Dodecoic acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Dodecoic acid is used for the manufacture of: textile, leather or fur.


Release to the environment of Dodecoic acid can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and as processing aid.
Release to the environment of Dodecoic acid can occur from industrial use: manufacturing of the substance.


Dodecoic acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.
Dodecoic acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.


In the laboratory, Dodecoic acid may be used to investigate the molar mass of an unknown substance via the freezing-point depression.
The choice of Dodecoic acid is convenient because the melting point of the pure compound is relatively high (43.8°C).
Its cryoscopic constant is 3.9°C•kg/mol.


By melting Dodecoic acid with the unknown substance, allowing it to cool, and recording the temperature at which the mixture freezes, the molar mass of the unknown compound may be determined.
In industry, Dodecoic acid is used as an intermediate and as a surface active agent.


Industrial applications of Dodecoic acid and its derivatives include the fatty acid as a component of alkyd resins, wetting agents, a rubber accelerator and softener, detergents, and insecticides.
The consumer market uses Dodecoic acid in the cleaning, furnishing, and production of personal care products.


Dodecoic acid has also been evaluated for use in aerosol formulations.
Dodecoic acid is used in the production of personal care products via the salt sodium laurate.
Dodecoic acid is also studied in metabolic and foodomics research for its potential impact on cardiovascular disease.


Dodecoic acid has been used as a reagent to synthesize MnFe2O4 magnetic nanoparticles by seed mediated growth method.
Dodecoic acid can undergo esterification with 2-ethylhexanol in the presence of sulfated zirconia catalyst to form 2-ethylhexanoldodecanoate, a biodiesel.
Like many other fatty acids, Dodecoic acid is inexpensive, has a long shelf-life, is nontoxic, and is safe to handle.


Dodecoic acid is used mainly for the production of soaps and cosmetics.
For these purposes, Dodecoic acid is reacted with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.


These precursors give mixtures of sodium laurate and other soaps.
Dodecoic acid is used for the preparation of alkyd resins, as well as wetting agents, detergents and pesticides
Dodecoic acid is used for peeling vegetables and fruits with a maximum amount of 3.0g/kg.


Dodecoic acid is used as defoamer; GB 2760-86 provides for the spices allowed to use; used for the preparation of other food grade additives.
Dodecoic acid is widely used in the surfactant industry and can be, according to the classification of surfactants, divided into cationic, anionic, non-ionic and amphoteric type.


The surfactants types of Dodecoic acid are listed in the attached table of this item.
Some surfactants of the derivatives of Dodecoic acid and dodecanol are also antiseptics, such as dodecyl dimethyl benzyl ammonium chloride (geramine), dodecyl dimethyl benzyl ammonium bromide (bromo-geramine) and dodecyl dimethyl (2-phenoxyethyl) ammonium bromide (domiphen bromide).


The dodecyldimethyllammonium-2,4,5-trichlorophenolate in these derivatives can be used as citrus preservative.
Dodecoic acid also has many applications in plastic additives, food additives, spices and pharmaceutical industries.
Given its foaming properties, the derivatives of lauric acid (h-Dodecoic acid) are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol.


In medicine, Dodecoic acid is known to increase total serum cholesterol more than many of the other fatty acids.
Common Uses and Applications of Dodecoic acid: Additive, Acidifiers, Chemical intermediate, Lubricant, Synthesis of substances, Industries, Chemical Production, Personal Care, and Laboratories.


Dodecoic acid is mainly used in the manufacturing of soaps and other cosmetics.
In scientific laboratories, Dodecoic acid is often used to investigate the molar mass of unknown substances via freezing-point depression.
In industry, Dodecoic acid is used as an intermediate and as a surface active agent.


The consumer market uses Dodecoic acid in the cleaning, furnishing, and production of personal care products.
In medicine, Dodecoic acid is known to increase total serum cholesterol more than many of the other fatty acids.
Dodecoic acid is mainly used in the manufacture and production of soaps and other cosmetics as well as scientific laboratory uses.


Dodecoic acid is used as an intermediate and surface active agent in industry and in the manufacture of personal care products in the consumer market.
Dodecoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.


Dodecoic acid is also used as a food additive and an active component in a treatment for acne.
In addition to this, Dodecoic acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.


Dodecoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.
Dodecoic acid is also used as a food additive and an active component in a treatment for acne.
In addition to this, Dodecoic acid is a substrate for acylation of certain proteins based on the murine studies.


Dodecoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
Dodecoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.
Dodecoic acid is also used as a food additive and an active component in a treatment for acne.


In addition to this, Dodecoic acid is a substrate for acylation of certain proteins based on the murine studies.
Dodecoic acid is generally used to produce cosmetic products but is also used in the laboratory to obtain the molar mass of substances.
Dodecoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.


Sodium lauryl sulfate is the most common Dodecoic acid derived compound used for this purpose.
Because Dodecoic acid has a non-polar hydrocarbon tail and a polar carboxylic acid head, it can interact with polar solvents (the most important being water) as well as fats, allowing water to dissolve fats.


This accounts for the abilities of shampoos to remove grease from hair.
Another use is to raise metabolism, believed to derive from Dodecoic acid's activation of 20% of thyroidal hormones, otherwise which lay dormant.
This is supposed from Dodecoic acid's release of enzymes in the intestinal tract which activate the thyroid.


This could account the metabolism-raising properties of coconut oil.
Because Dodecoic acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle, it is often used in laboratory investigations of melting-point depression.


Dodecoic acid is a solid at room temperature but melts easily in boiling water, so liquid it can be treated with various solutes and used to determine their molecular masses.
Dodecoic acid is widely used in cosmetics and food products.


In pharmaceutical applications Dodecoic acid has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery, and intestinal absorption.
Dodecoic acid is also useful for stabilizing oil-in-water emulsions.



Dodecoic acid is a common constituent of vegetable fats, especially coconut oil and laurel oil.
Dodecoic acid may have a synergistic effect in a formula to help fight against mircoorganisms.
Dodecoic acid is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.


Dodecoic acid is a fatty acid obtained from coconut oil and other veg- etable fats.
Dodecoic acid is practically insoluble in water but is soluble in alcohol, chloroform, and ether.


Dodecoic acid functions as a lubricant, binder, and defoaming agent.
Dodecoic acid is used intermediates of Liquid Crystals
Dodecoic acid is also used as a food additive and an active component in a treatment for acne.


-Uses of Dodecoic acid in Perfume:
Dodecoic acid is used in Butter flavors and in certain Citrus flavor types, mainly in Lemon.
The concentration of Dodecoic acid used may vasy from 2 to 40 ppm, calculated upon the finished consumer product.


-Pharmaceutical Applications of Dodecoic acid:
pharmaceutical applications it has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery,(14) and intestinal absorption.
Dodecoic acid is also useful for stabilizing oil-in-water emulsions.
Dodecoic acid has also been evaluated for use in aerosol formulations.



SOLUBILITY OF DODECOIC ACID:
Dodecoic acid is soluble in water, benzene, acetone, alcohol, petroleum ether, dimethyl sulfoxide and dimethyl formamide.
Dodecoic acid is slightly soluble in chloroform.



NOTES OF DODECOIC ACID:
Dodecoic acid is incompatible with bases, oxidizing agents and reducing agents.



ALTERNATIVE PARENTS OF DODECOIC ACID:
*Dicarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SOURCE AND PREPARATION OF DODECOIC ACID:
Dodecoic acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of Dodecoic acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.



OCCURRENCE OF DODECOIC ACID:
Dodecoic acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil (not to be confused with palm oil).
Otherwise Dodecoic acid is relatively uncommon.
Dodecoic acid is also found in human breast milk ( 6.2 % of total fat), cow's milk (2.9%), and goat's milk (3.1 %).



SAFETY OF DODECOIC ACID:
Dodecoic acid is widely used in cosmetic preparations, in the manufacture of food-grade additives, and in pharmaceutical formulations.
General exposure to Dodecoic acid occurs through the consumption of food and through dermal contact with cosmetics, soaps, and detergent products.

Occupational exposure may cause local irritation of eyes, nose, throat, and respiratory tract, although Dodecoic acid is considered safe and nonirritating for use in cosmetics.
No toxicological effects were observed when Dodecoic acid was administered to rats at 35% of the diet for 2 years.



SUBSTITUENTS OF DODECOIC ACID:
*Medium-chain fatty acid
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



WHERE TO FIND DODECOIC ACID:
Dodecoic acid is a powerful substance that’s sometimes extracted from the coconut for use in developing monolaurin.
Monolaurin is an antimicrobial agent that’s able to fight pathogens such as bacteria, viruses, and yeasts.



OCCURRENCE OF DODECOIC ACID:
Dodecoic acid, as a component of triglycerides, comprises about half of the fatty-acid content in coconut milk, coconut oil, laurel oil, and palm kernel oil (not to be confused with palm oil).

Otherwise, Dodecoic acid is relatively uncommon.
Dodecoic acid is also found in human breast milk (6.2% of total fat), cow's milk (2.9%), and goat's milk (3.1%).

In various plants:
*The palm tree Attalea speciosa, a species popularly known in Brazil as babassu – 50% in babassu oil
*Attalea cohune, the cohune palm (also rain tree, American oil palm, corozo palm or manaca palm) – 46.5% in cohune oil
*Astrocaryum murumuru (Arecaceae) a palm native to the Amazon – 47.5% in "murumuru butter"
*Coconut oil 49%
*Pycnanthus kombo (African nutmeg)
*Virola surinamensis (wild nutmeg) 7.8–11.5%
*Peach palm seed 10.4%
*Betel nut 9%
*Date palm seed 0.56–5.4%
*Macadamia nut 0.072–1.1%
*Plum 0.35–0.38%
*Watermelon seed 0.33%
*Viburnum opulus 0.24-0.33%
*Citrullus lanatus (egusi melon)
*Pumpkin flower 205 ppm, pumpkin seed 472 ppm
*Insect
*Black soldier fly Hermetia illucens 30–50 mg/100 mg fat.



COMPOUND TYPE OF DODECOIC ACID:
*Animal Toxin
*Cosmetic Toxin
*Food Toxin
*Industrial/Workplace Toxin
*Metabolite
*Natural Compound
*Organic Compound
*Plasticizer



CHEMICAL PROPERTIES OF DODECOIC ACID:
Dodecoic acid is a colorless needle-like crystals.
Dodecoic acid is soluble in methanol, slightly soluble in acetone and petroleum ether.



STABILITY AND STORAGE CONDITIONS OF DODECOIC ACID:
Dodecoic acid is stable at normal temperatures and should be stored in a cool, dry place.



MEDIUM-CHAIN TRIGLYCERIDES OF DODECOIC ACID:
Medium-chain triglycerides, or fatty acids, such as Dodecoic acid, are characterized by a specific chemical structure that allows your body to absorb them whole.

This makes them more easily digestible--your body processes them as it would carbohydrates, and they are used as a source of direct energy.
Compared to long-chain triglycerides, the type in other saturated fats, MCTs have fewer calories per serving, roughly 8.3 calories per gram rather than the standard 9 calories per gram, according to an article in "Nutrition Review."



NUTRITIONAL AND MEDICAL ASPECTS OF DODECOIC ACID:
Although 95% of medium-chain triglycerides are absorbed through the portal vein, only 25–30% of Dodecoic acid is absorbed through it.
Dodecoic acid induces apoptosis in cancer and promotes the proliferation of normal cells by maintaining cellular redox homeostasis.
Dodecoic acid increases total serum lipoproteins more than many other fatty acids, but mostly high-density lipoprotein (HDL).

As a result, Dodecoic acid has been characterized as having "a more favorable effect on total HDL than any other fatty acid [examined], either saturated or unsaturated".
In general, a lower total/HDL serum lipoprotein ratio correlates with a decrease in atherosclerotic incidence.

Nonetheless, an extensive meta-analysis on foods affecting the total LDL/serum lipoprotein ratio found in 2003 that the net effects of Dodecoic acid on coronary artery disease outcomes remained uncertain.
A 2016 review of coconut oil (which is nearly half Dodecoic acid) was similarly inconclusive about the effects on cardiovascular disease incidence.



INCLUDING DODECOIC ACID IN YOUR DIET:
Dodecoic acid can be taken as a supplement, but it is most commonly consumed as part of coconut oil or palm kernel oil.
Dodecoic acid is considered to be safe based on the amounts generally found in food.

According to NYU Langone Medical Center, coconut and palm kernel oil contain up to 15 percent MCTs, along with a number of other fats.
However, because they are still pure oil, limit your intake of MCTs to stay within the recommended 5 to 7 teaspoons of oil per day as set out by the U.S. Department of Agriculture.

You can use coconut and palm kernel oil for stir-fries because both oils withstand high heat.
They can also be used in baking, adding a natural richness to your food.



AROMA THRESHOLD VALUES OF DODECOIC ACID:
Aroma threshold values
Aroma characteristics at 1.0%: fatty, creamy, cheeselike, candle waxy with egglike richness



TASTE THRESHOLD VALUES OF DODECOIC ACID:
Taste characteristics at 5 ppm: waxy,fatty and oily, tallowlike, creamy and dairylike with a coating mouthfeel



REACTIVITY PROFILE OF DODECOIC ACID:
Dodecoic acid is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.

Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Dodecoic acid to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.



PRODUCTION METHODS OF DODECOIC ACID:
Dodecoic acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of Dodecoic acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.



PHYSICAL PROPERTIES OF DODECOIC ACID:
Dodecoic acid occurs as a white crystalline powder with a slight odor of bay oil or a fatty odor.
Dodecoic acid is a common constituent of most diets; large doses may produce gastrointestinal upset.



CHEMICAL PROPERTIES OF DODECOIC ACID:
Like many other fatty acids, Dodecoic acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.
Dodecoic acid is mainly used for the production of soaps and cosmetics.

For these purposes, Dodecoic acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.
These precursors give mixtures of sodium laurate and other soaps.



PRODUCTION METHODS OF DODECOIC ACID:
1. Industrial production methods can be grouped into two categories:
* derived from the saponification or high temperature and pressure decomposition of natural vegetable oils and fats;
* separated from the synthetic fatty acid.

Japan mainly uses coconut oil and palm kernel oil as the raw materials for the preparation of Dodecoic acid.
The natural vegetable oils used to produce Dodecoic acid include coconut oil, litsea cubeba kernel oil, palm kernel oil and mountain pepper seed oil.

Other plants oil, such as palm kernel oil, tea tree seed oil and camphor tree seed oil, can also service industry to produce Dodecoic acid.
The residual C12 distillate from the extraction of Dodecoic acid, containing a large number of dodecenoic acid, can be hydrogenated at atmospheric pressure, without catalyst, to convert into Dodecoic acid with a yield of more than 86%.

2. Derived from the separation and purification of coconut oil and other vegetable oil.

3. Dodecoic acid naturally exists in coconut oil, litsea cubeba kernel oil, palm kernel oil and pepper kernel oil in the form of glyceride.
Dodecoic acid can be derived from the hydrolysis of natural oils and fats in industry.
The coconut oil, water and catalyst are added into the autoclave and hydrolyzed to glycerol and fatty acid at 250 ℃ under the pressure of 5MPa.
The content of Dodecoic acid is 45%~80%, and can be further distilled to obtain Dodecoic acid.



AIR AND WATER REACTIONS OF DODECOIC ACID:
Dodecoic acid is insoluble in water.



PHYSICAL and CHEMICAL PROPERTIES of DODECOIC ACID:
Melting point: 133-137 °C (lit.)
Boiling point: 294.5 °C/100 mmHg (lit.)
Density: 1.21
vapor pressure: 1 mm Hg ( 183 °C)
refractive index: 1.422
Flash point: 220 °C
storage temp.: Store below +30°C.
solubility: ethanol: 100 mg/mL
form: Powder or Granules
pka: 4.59, 5.59(at 25℃)
color: White to off-white
Water Solubility: 1 g/L (20 ºC)
Merck: 14,8415

BRN: 1210591
Stability: Stable.
LogP: 1.5 at 23℃
Appearance: white granular powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 130.80 °C. @ 760.00 mm Hg
Boiling Point: 364.00 to 365.00 °C. @ 760.00 mm Hg
Boiling Point: 235.00 to 234.00 °C. @ 10.00 mm Hg
Flash Point: 389.00 °F. TCC ( 198.30 °C. ) (est)
logP (o/w): 1.706 (est)
Soluble in: water, 1000 mg/L @ 20 °C (exp)
water, 1420 mg/L @ 25 °C (est)

Chemical formula: C12H24O2
Molar mass: 200.322 g•mol−1
Appearance: White powder
Odor: Slight odor of bay oil
Density: 1.007 g/cm³ (24 °C),
0.8744 g/cm³ (41.5 °C),
0.8679 g/cm³ (50 °C)
Melting point: 43.8 °C (110.8 °F; 316.9 K)
Boiling point: 297.9 °C (568.2 °F; 571.0 K),
282.5 °C (540.5 °F; 555.6 K) at 512 mmHg,
225.1 °C (437.2 °F; 498.2 K) at 100 mmHg
Solubility in water: 37 mg/L (0 °C), 55 mg/L (20 °C),
63 mg/L (30 °C), 72 mg/L (45 °C), 83 mg/L (100 °C)

Solubility: Soluble in alcohols, diethyl ether,
phenyls, haloalkanes, acetates
Solubility in methanol: 12.7 g/100 g (0 °C),
120 g/100 g (20 °C), 2250 g/100 g (40 °C)
Solubility in acetone: 8.95 g/100 g (0 °C),
60.5 g/100 g (20 °C), 1590 g/100 g (40 °C)
Solubility in ethyl acetate: 9.4 g/100 g (0 °C),
52 g/100 g (20°C), 1250 g/100 g (40°C)
Solubility in toluene: 15.3 g/100 g (0 °C),
97 g/100 g (20°C), 1410 g/100 g (40°C)
log P: 4.6

Vapor pressure: 2.13•10−6 kPa (25 °C),
0.42 kPa (150 °C),
6.67 kPa (210 °C)
Acidity (pKa): 5.3 (20 °C)
Thermal conductivity: 0.442 W/m•K (solid),
0.1921 W/m•K (72.5 °C),
0.1748 W/m•K (106 °C)
Refractive index (nD): 1.423 (70 °C),
1.4183 (82 °C)
Viscosity: 6.88 cP (50 °C), 5.37 cP (60 °C)
Structure:
Crystal structure: Monoclinic (α-form),
Triclinic, aP228 (γ-form)

Space group: P21/a, No. 14 (α-form), P1, No. 2 (γ-form)
Point group: 2/m (α-form)[8], 1 (γ-form)[9]
Lattice constant: a = 9.524 Å, b = 4.965 Å,
c = 35.39 Å (α-form),
α = 90°, β = 129.22°, γ = 90°
Thermochemistry:
Heat capacity (C): 404.28 J/mol•K
Std enthalpy of formation (ΔfH⦵298): −775.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298): 7377 kJ/mol,
7425.8 kJ/mol (292 K)
Molecular Weight: 200.32 g/mol
XLogP3: 4.2
Hydrogen Bond Donor Count: 1

Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 10
Exact Mass: 200.177630004 g/mol
Monoisotopic Mass: 200.177630004 g/mol
Topological Polar Surface Area: 37.3Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 132
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
IUPAC Name: dodecanoic acid
Traditional IUPAC Name: lauric acid
Formula: C12H24O2
InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChI Key: POULHZVOKOAJMA-UHFFFAOYSA-N
Molecular weight: 200.3178
Exact mass: 200.177630012
SMILES: CCCCCCCCCCCC(O)=O

Chemical formula: C10H18O4
Molar mass: 202.250 g•mol−1
Density: 1.209 g/cm3
Melting point: 131 to 134.5 °C (267.8 to 274.1 °F; 404.1 to 407.6 K)
Boiling point: 294.4 °C (561.9 °F; 567.5 K) at 100 mmHg
Solubility in water: 0.25 g/L
Acidity (pKa): 4.720, 5.450
Molecular Weight: 202.25
XLogP3: 2.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4

Rotatable Bond Count: 9
Exact Mass: 202.12050905
Monoisotopic Mass: 202.12050905
Topological Polar Surface Area: 74.6 Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 157
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: powder
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 133 - 137 °C - lit.
Initial boiling point and boiling range: 294,5 °C at 133 hPa - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available

Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0,224 g/l at 20 °C - OECD Test Guideline 105
Partition coefficient:
n-octanol/water: log Pow: 1,5 at 23 °C
Vapor pressure: 1 hPa at 183 °C
Density: 1,210 g/cm3 at 20 °C

Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Water Solubility: 0.91 g/L
logP: 1.93
logP: 2.27
logS: -2.4
pKa (Strongest Acidic): 4.72

Physiological Charge: -2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 2
Polar Surface Area: 74.6 Ų
Rotatable Bond Count: 9
Refractivity: 51.14 m³•mol⁻¹
Polarizability: 22.61 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: No
MDDR-like Rule: No

Chemical Formula: C12H24O2
Average Molecular Weight: 200.3178
Monoisotopic Molecular Weight: 200.177630012
IUPAC Name: dodecanoic acid
Traditional Name: lauric acid
CAS Registry Number: 143-07-7
SMILES: CCCCCCCCCCCC(O)=O
InChI Identifier: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChI Key: POULHZVOKOAJMA-UHFFFAOYSA-N
Synonyms: n-Dodecanoic acid
IUPAC Name: Dodecanoic acid
Canonical SMILES: CCCCCCCCCCCC(=O)O
InChI: POULHZVOKOAJMA-UHFFFAOYSA-N

InChI Key: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
Boiling Point: 225 °C 100mmHg(lit.)
Melting Point: 44-46 °C(lit.)
Flash Point: 156ºC
Density: 0.883g/ml
Appearance: Clear liquid
Storage: Room temperature
CNo.Chain: C12:0
Compound Derivative: Acid
EC Number: 205-582-1
Fatty Acid: Dodecanoic (Lauric)
Hazard Codes: Xi

Hazard Statements: Xi
HS Code: 2916399090
LogP: 3.99190
MDL Number: MFCD00002736
Physical State: Solid
PSA: 37.3
Refractive Index: 1.4304
Safety Description: 37/39-26-39-36
Stability: Stable.
Incompatible with bases, oxidizing agents, reducing agents.
Storage Conditions: Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances.

Supplemental Hazard Statements: H401-H318-H319
Symbol: GHS05, GHS07
Vapor Pressure: 1 mm Hg ( 121 °C)
Formula: C12H24O2
InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
Molecular Weight: 200.322 g/mol
SMILES: OC(CCCCCCCCCCC)=O
SPLASH: splash10-0706-9000000000-b974e08e305014657f85
Source of Spectrum: HE-1982-0-0
CB Number: CB0357278
Molecular Formula: C12H24O2
Lewis structure
Molecular Weight: 200.32

MDL Number: MFCD00002736
MOL File: 143-07-7.mol
Melting point: 44-46 °C (lit.)
Boiling point: 225 °C/100 mmHg (lit.)
Density: 0.883 g/mL at 25 °C (lit.)
Vapor pressure: 1 mm Hg (121 °C)
Refractive index: 1.4304
FEMA: 2614 | LAURIC ACID
Flash point: >230 °F
Storage temp.: 2-8°C
Solubility: 4.81 mg/L
Form: Crystalline Powder of Flakes
pKa: 4.92 (H2O, t =25.0) (Uncertain)
Specific Gravity: 0.883
Color: White

Odor: at 100.00 % mild fatty coconut bay oil
Odor Type: fatty
Explosive limit: 0.6% (V)
Water Solubility: insoluble
λmax: 207 nm (MeOH) (lit.)
JECFA Number: 111
Merck: 14,5384
BRN: 1099477
Stability: Stable.
Incompatible with bases, oxidizing agents, reducing agents.
InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
LogP: 5

Dissociation constant: 5.3 at 20°C
Substances Added to Food (formerly EAFUS): LAURIC ACID
CAS DataBase Reference: 143-07-7 (CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 1160N9NU9U
NIST Chemistry Reference: Dodecanoic acid (143-07-7)
EPA Substance Registry System: Lauric acid (143-07-7)
Molecular Weight: 200.32
Exact Mass: 200.32
BRN: 1099477
EC Number: 205-582-1
HS Code: 29159010

Characteristics
PSA: 37.3
XLogP3: 4.2
Appearance: White Crystalline Powder of Flakes
Density: 0.883 g/cm³ @ Temp: 20 °C
Melting Point: 44.2 °C
Boiling Point: 298.9 °C
Flash Point: >230 °F
Refractive Index: 1.4304
Water Solubility: H2O: insoluble
Storage Conditions: Store below +30°C
Vapor Pressure: 1 mm Hg (121 °C)
Toxicity: LD50 i.v. in mice: 131 ±5.7 mg/kg (Or, Wretlind)
Explosive limit: 0.6% (V)
Odor: Characteristic, like oil of bay
pKa: 5.3 (at 20 °C)



FIRST AID MEASURES of DODECOIC ACID:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DODECOIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of DODECOIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DODECOIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DODECOIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry



STABILITY and REACTIVITY of DODECOIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Conditions to avoid:
no information available