Paint, Construction, Plastics, Rubber Chemicals

FLUOROBORIC ACID
SYNONYMS Tetrafluoroboric acid; Hydrogen Tetrafluoroborate; Hydrofluoroboric acid; Borofluoric acid; Borate(1-), tetrafluoro-, hydrogen CAS NO. 16872-11-0
FOAMSTAR SI 2210
DESCRIPTION:
FOAMSTAR SI 2210 is a defoamer for non-pigmented and low-pigmented aqueous coatings, printing inks, adhesives and UV-curable systems.
FOAMSTAR SI 2210 has a spontaneous defoaming effect in low- and nonpigmented aqueous coatings.
FOAMSTAR SI 2210 is highly compatible, does not separate out from the paint and has a good long-term efficiency.

CHEMICAL NATURE:
FOAMSTAR SI 2210 is blend of specially modified alcohols and a polysiloxane adduct
Aqueous wood coatings and overprint varnishes based on acrylic polymers are the preferential fields of application, but the defoamer is also suitable for contact adhesives.
FOAMSTAR SI 2210 is defoamer for non-pigmented and low-pigmented aqueous coatings, printing inks, adhesives and UV-curable systems.

FOAMSTAR SI 2210 has spontaneous defoaming effect.
FOAMSTAR SI 2210 is highly compatible.

TYPICAL PROPERTIES OF FOAMSTAR SI 2210:
physical form: colorless to slightly yellowish, clear to slightly hazy liquid
storage: FoamStar SI 2210 should always be stored in tightly closed containers.
Store in a cool place.
refractive index at 20 °C: ~ 1.44
density at 20 °C (68 °F): ~ 0.95 g/cm3
viscosity: ~ 75 mPa*s


APPLICATIONS OF FOAMSTAR SI 2210:
FoamStar SI 2210 is characterized by a spontaneous defoaming effect in low- and non-pigmented aqueous coatings.
FoamStar SI 2210 is highly compatible, does not separate out from the paint and has a good long-term efficiency.
Aqueous wood coatings and overprint varnishes based on acrylic polymers are the preferred fields of application, but the defoamer is also suitable for adhesives.

FoamStar SI 2210 is a waterborne, modified polydimethylsiloxane-based defoamer.
FoamStar SI 2210 provides a strong spontaneous defoaming effect and outstanding long-term defoaming persistency.
FoamStar SI 2210 is suitable for non-pigmented and low-pigmented aqueous coatings, printing inks, and UV-curable systems.

FoamStar SI 2210 is recommended for low-VOC systems.
FoamStar SI 2210 is used in matt/interior, silk/semi-gloss, wood paints and stains, plasters, gloss-, exterior- and elastic paints.

FoamStar SI 2210 is a blend of specially modified alcohols and polysiloxane adduct.
FoamStar SI 2210 Offers long-term efficiency.
FoamStar SI 2210 is Suitable for UV-curable systems.

FoamStar SI 2210 is recommended for low-VOC systems, sealants and flooring adhesives.
FoamStar SI 2210 is also suitable for contact adhesives.
FoamStar SI 2210 is a non-APEO product.

Recommended dosage level is 0.1-0.5%.
FoamStar SI 2210 has a shelf life of 2 years.

SAFETY INFORMATION ABOUT FOAMSTAR SI 2210:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.








FOAMSTOP 600 N

Foamstop 600 N is a chemical compound used as an antifoam agent or defoamer.
Foamstop 600 N is specifically formulated to control foam formation in various industrial processes and applications.
Antifoam agents like Foamstop 600 N are typically added to systems where excessive foam formation can hinder efficiency, quality, or safety.

Antifoam, defoamer, foam control agent, foam inhibitor, foam suppressor, foam destroyer, foam reducer, foam eliminator, foam control additive, foam-busting agent, antifoaming agent, antifrothing agent, antiserum, antiponding agent, foam stabilizer, antifizzing agent, antifoaming compound, foam knockout agent, anti-bubbling agent, defoaming agent, foam suppressant, foam breaker, foam destabilizer, foam-reducing additive, foam killer, foam inhibitor chemical, defoaming additive, defoaming compound, foam control solution



APPLICATIONS


Antifoam agents like Foamstop 600 N find widespread use in the chemical industry to control foam during various chemical reactions and processes.
They are employed in the production of polymers, resins, and plastics to prevent foam formation and maintain process efficiency.

In the pharmaceutical industry, Foamstop 600 N is used in drug manufacturing processes to control foam during fermentation, extraction, and purification steps.
Antifoam agents are essential in the production of food and beverages to prevent foam formation in fermentation tanks, mixing vessels, and packaging lines.
Foamstop 600 N is added to dairy processing operations, such as milk pasteurization and cheese making, to prevent foam buildup and improve product quality.

Foamstop 600 N is utilized in breweries and wineries to control foam during fermentation, aging, and bottling processes.
In the pulp and paper industry, Foamstop 600 N is used to control foam in pulp washing, paper coating, and wastewater treatment processes.
Antifoam agents are applied in textile manufacturing to prevent foam buildup in dyeing, printing, and finishing operations.

Foamstop 600 N finds use in metalworking fluids to control foam during machining, grinding, and metal cleaning processes.
Foamstop 600 N is utilized in wastewater treatment plants to prevent foam formation in aeration tanks, clarifiers, and digesters.
Foamstop 600 N is employed in mining and mineral processing operations to control foam in flotation cells, thickener tanks, and tailings ponds.

Antifoam agents are added to oil and gas production processes to prevent foam formation in drilling fluids, well stimulation fluids, and production separators.
Foamstop 600 N finds application in biotechnology and fermentation processes to control foam in bioreactors, fermenters, and cell culture systems.
They are utilized in the production of household and personal care products to prevent foam buildup in detergents, shampoos, and cosmetics.

Foamstop 600 N is essential in the agricultural industry for controlling foam in pesticide formulations, crop protection products, and fertilizer solutions.
Foamstop 600 N is added to paints, coatings, and adhesives to prevent foam formation during manufacturing, mixing, and application.
Foamstop 600 N finds use in the automotive industry to control foam in coolant systems, parts cleaning baths, and metalworking fluids.
Foamstop 600 N is employed in the construction industry to prevent foam buildup in concrete admixtures, grouts, and sealants.

Foamstop 600 N is added to water treatment chemicals to prevent foam formation in cooling towers, boilers, and wastewater treatment plants.
They find application in the printing and packaging industry to control foam in printing inks, coatings, and adhesives.
Foamstop 600 N is utilized in the electronics industry to prevent foam formation in chemical cleaning solutions and plating baths.
Foamstop 600 N is added to drilling fluids in the geothermal and mining industries to prevent foam formation in drilling operations.

Foamstop 600 N finds use in the pharmaceutical and biotechnology industries to prevent foam formation in cell culture media and fermentation broths.
Foamstop 600 N is applied in the production of specialty chemicals, such as surfactants and emulsifiers, to control foam during synthesis and formulation.
Foamstop 600 N is essential in industries where foam control is critical for maintaining process efficiency, product quality, and safety standards.

Antifoam agents find extensive use in the wastewater treatment industry to control foam in aerobic and anaerobic biological treatment processes.
Foamstop 600 N is added to sewage treatment plants to prevent foam formation in primary settling tanks, aeration basins, and secondary clarifiers.
Foamstop 600 N is employed in the production of specialty chemicals, such as surfactants and polymers, to prevent foam formation during synthesis and purification steps.
Foamstop 600 N is utilized in the production of petrochemicals and refinery products to control foam in distillation columns, reactors, and storage tanks.

Foamstop 600 N is added to latex and rubber manufacturing processes to prevent foam formation during latex compounding, foaming, and curing.
Foamstop 600 N finds use in the construction industry for controlling foam in grouts, mortar mixes, and concrete additives used in construction projects.
Antifoam agents are applied in the pharmaceutical industry to prevent foam formation during tablet coating, granulation, and liquid filling operations.
Foamstop 600 N is added to polymerization reactions to prevent foam formation and maintain optimal reaction conditions in polymer manufacturing processes.

Foamstop 600 N is employed in the production of adhesives and sealants to prevent foam formation during mixing, application, and curing stages.
Antifoam agents find use in the textile industry for controlling foam in dyeing, bleaching, and finishing processes used in fabric manufacturing.
Foamstop 600 N is added to agricultural sprays and pesticide formulations to prevent foam formation during mixing, spraying, and application in crop fields.

Foamstop 600 N is utilized in the production of ceramics and glass to prevent foam formation in slip casting, glazing, and firing processes.
Antifoam agents find application in the cosmetics industry for controlling foam in skincare products, haircare formulations, and personal care items.
Foamstop 600 N is added to fermentation processes in the food and beverage industry to prevent foam formation in beer, wine, and other fermented beverages.

Foamstop 600 N is employed in the production of sugar and ethanol to prevent foam formation in fermentation tanks and distillation columns.
Foamstop 600 N finds use in the automotive industry for controlling foam in coolant systems, parts cleaning solutions, and metalworking fluids used in manufacturing.

Foamstop 600 N is added to lubricants and hydraulic fluids to prevent foam formation and maintain lubrication performance in industrial machinery.
They are utilized in the production of batteries and electronic components to prevent foam formation in electrolyte solutions and chemical cleaning baths.
Foamstop 600 N finds application in the paper recycling industry for controlling foam in pulping, deinking, and papermaking processes.

Foamstop 600 N is added to asphalt and bitumen emulsions to prevent foam formation during mixing, paving, and road construction activities.
Foamstop 600 N is employed in the production of paint and coatings to prevent foam formation during mixing, spraying, and curing stages.

Antifoam agents find use in the mining industry for controlling foam in flotation cells, mineral processing circuits, and tailings ponds.
Foamstop 600 N is added to drilling muds and drilling fluids in the oil and gas industry to prevent foam formation during drilling and well completion operations.

Foamstop 600 N is utilized in the production of surfactants and detergents to prevent foam formation during manufacturing and packaging processes.
Antifoam agents find application in various industrial processes where foam control is essential for maintaining operational efficiency, product quality, and safety standards.

Antifoam agents find use in the production of paints and coatings to prevent foam formation during mixing, stirring, and application.
Foamstop 600 N is added to wastewater treatment processes to prevent foam formation in sewage treatment plants, industrial effluent treatment facilities, and lagoons.
Foamstop 600 N is employed in the manufacturing of detergents and cleaning agents to prevent foam formation in washing machines, dishwashers, and industrial cleaning equipment.
Foamstop 600 N is utilized in the pulp and paper industry to control foam in pulp washing, paper forming, and paper coating processes.

Foamstop 600 N is added to cooling water systems to prevent foam formation in cooling towers, heat exchangers, and evaporative condensers.
Foamstop 600 N is applied in the production of ceramics and pottery to prevent foam formation in clay slurries, glazes, and kiln firing processes.
Foamstop 600 N finds use in the pharmaceutical industry for controlling foam in drug manufacturing processes, including fermentation, extraction, and drying operations.

Foamstop 600 N is added to animal feed processing operations to prevent foam formation in feed mixers, pellet mills, and extruders.
Foamstop 600 N is employed in the production of personal care products, such as lotions, creams, and foaming bath products, to prevent excessive foam formation.
Antifoam agents find application in the manufacturing of rubber and latex products to prevent foam formation during compounding, vulcanization, and molding processes.

Foamstop 600 N is added to fermentation processes in the biotechnology industry to prevent foam formation in bioreactors, fermenters, and cell culture vessels.
Foamstop 600 N is utilized in the production of dietary supplements and nutraceuticals to prevent foam formation in encapsulation, granulation, and tableting processes.
Antifoam agents find use in the production of pet food and animal feed to prevent foam formation in mixing, extrusion, and drying operations.
Foamstop 600 N is added to industrial wastewater treatment processes to prevent foam formation in activated sludge systems, trickling filters, and anaerobic digesters.

Foamstop 600 N is employed in the production of adhesives and sealants to prevent foam formation during mixing, dispensing, and curing processes.
Antifoam agents find application in the agricultural industry for controlling foam in pesticide spraying, irrigation, and fertilizer application processes.
Foamstop 600 N is added to fermentation processes in the brewing and distilling industries to prevent foam formation in beer and spirits production.

Foamstop 600 N is utilized in the production of flavors and fragrances to prevent foam formation in blending, distillation, and extraction processes.
Foamstop 600 N finds use in the construction industry for controlling foam in concrete admixtures, grouts, and sealants used in building and infrastructure projects.
Foamstop 600 N is added to textile dyeing and printing processes to prevent foam formation in dye baths, printing pastes, and finishing baths.

Foamstop 600 N is employed in the production of rubber and plastic products to prevent foam formation in molding, extrusion, and foaming processes.
Antifoam agents find application in the manufacturing of fiberglass and composite materials to prevent foam formation in resin impregnation and curing processes.

Foamstop 600 N is added to metalworking fluids to prevent foam formation in machining, grinding, and metal cleaning operations.
Foamstop 600 N is utilized in the production of building materials, such as insulation foams and foam plastics, to prevent excessive foam formation during manufacturing.
Antifoam agents find use in various industrial processes and applications where foam control is necessary to maintain product quality, process efficiency, and operational safety.



DESCRIPTION


Foamstop 600 N is a chemical compound used as an antifoam agent or defoamer.
Foamstop 600 N is specifically formulated to control foam formation in various industrial processes and applications.
Antifoam agents like Foamstop 600 N are typically added to systems where excessive foam formation can hinder efficiency, quality, or safety.

The exact composition and properties of Foamstop 600 N may vary depending on the manufacturer and specific formulation.
However, antifoam agents commonly contain a blend of silicone-based compounds, hydrophobic solids, and other additives designed to disrupt foam bubbles and prevent their formation or stability.

Antifoam agents like Foamstop 600 N are specially formulated compounds designed to control foam formation in industrial processes.
These agents are typically composed of a blend of active ingredients that work synergistically to disrupt and collapse foam bubbles.
Foamstop 600 N is a versatile antifoam agent used across various industries to address foam-related challenges.

Foamstop 600 N is available in different formulations, including liquids, emulsions, and powders, to suit different applications and process requirements.
The active components of Foamstop 600 N are often hydrophobic substances that have a high affinity for air-liquid interfaces.
When added to foaming systems, Foamstop 600 N quickly spreads across the surface of the foam and breaks down the foam structure.

The antifoam action of Foamstop 600 N is rapid and effective, leading to the collapse of foam bubbles and the elimination of foam.
Foamstop 600 N acts by lowering the surface tension of the foam, preventing the formation of stable foam structures.

Foamstop 600 N is non-reactive with other process chemicals and does not affect the properties or performance of the final product.
Foamstop 600 N is compatible with a wide range of industrial processes, including chemical manufacturing, food processing, and wastewater treatment.
Foamstop 600 N is effective in controlling foam generated by various mechanisms, including agitation, aeration, and surfactant action.

Foamstop 600 N can be added directly to the foaming system or applied as a surface treatment to existing foam.
The dosage of Foamstop 600 N required depends on factors such as the severity of foam formation, the nature of the foaming agents, and the process conditions.
Foamstop 600 N is known for its stability and long-lasting antifoam action, providing continuous foam control over extended periods.
Foamstop 600 N is resistant to degradation by heat, pH changes, and shear forces, making it suitable for use in harsh operating conditions.

Foamstop 600 N is easy to handle and can be stored for extended periods without significant loss of effectiveness.
Foamstop 600 N is non-toxic, non-corrosive, and environmentally friendly, making it safe for use in food and pharmaceutical applications.
Foamstop 600 N is available in various packaging options, including drums, totes, and bulk containers, to accommodate different usage volumes.

Foamstop 600 N is manufactured under strict quality control measures to ensure consistency and reliability in performance.
Foamstop 600 N is often used in combination with other process additives to optimize performance and efficiency.

Foamstop 600 N is a cost-effective solution for foam control, helping to reduce downtime, improve productivity, and minimize product losses.
Foamstop 600 N can be customized to meet specific customer requirements and application needs.
Foamstop 600 N undergoes rigorous testing and evaluation to ensure compliance with regulatory standards and industry specifications.

Foamstop 600 N is backed by technical support and expertise from the manufacturer, ensuring proper application and troubleshooting assistance.
Overall, Foamstop 600 N is an essential tool for managing foam-related challenges in industrial processes, offering reliable and effective foam control solutions.



PROPERTIES


Chemical Composition: Foamstop 600 N is typically composed of a blend of active ingredients, including silicone-based compounds, hydrophobic solids, and emulsifiers.
Physical Form: It is available in various physical forms, including liquids, emulsions, powders, and granules.
Appearance: The appearance of Foamstop 600 N varies depending on its physical form, ranging from clear liquids to white powders or granules.
Odor: Foamstop 600 N may have a slight odor characteristic of its chemical composition, but it is generally odorless or has a mild, non-offensive scent.
Solubility: It is typically insoluble in water but dispersible in aqueous solutions, forming stable emulsions or suspensions.
Density: The density of Foamstop 600 N varies depending on its physical form and concentration, typically ranging from 0.8 to 1.2 g/cm³ for liquids and emulsions.
pH: Foamstop 600 N formulations are usually pH-neutral or slightly acidic to mildly alkaline, with pH values ranging from 5 to 9.
Surface Tension: It has the ability to reduce the surface tension of liquid films, facilitating the disruption and collapse of foam bubbles.



FIRST AID


Inhalation:

If inhaled, remove the affected individual to fresh air immediately.
Ensure that the person is breathing and administer artificial respiration if necessary.
Seek medical attention if respiratory distress persists or if symptoms worsen.


Skin Contact:

Remove contaminated clothing and immediately rinse the affected skin with plenty of water.
Use mild soap or a gentle cleanser to thoroughly wash the skin and remove any residual Foamstop 600 N.
If irritation or redness develops, seek medical advice and avoid further contact with the chemical.


Eye Contact:

Flush the eyes with lukewarm water for at least 15 minutes, ensuring that eyelids are held open and thoroughly rinsed.
Seek immediate medical attention, and continue irrigation while transporting the affected individual to a medical facility.
Remove contact lenses if present and easily removable after flushing begins.


Ingestion:

Do not induce vomiting unless instructed to do so by medical personnel.
Rinse the mouth with water and give the affected individual a small amount of water or milk to drink.
Seek medical attention immediately and provide medical personnel with information on the ingested amount and any symptoms observed.


General Advice:

Keep emergency contact information readily accessible in case medical assistance is needed.
Provide medical personnel with the Safety Data Sheet (SDS) or product label for Foamstop 600 N.
Follow any specific first aid instructions provided on the product label or by medical professionals.
Do not administer any medications or home remedies unless instructed to do so by medical personnel.
If treating someone else, ensure personal safety by wearing appropriate protective equipment.
In case of any doubt or uncertainty about the severity of exposure, seek medical advice promptly.



HANDLING AND STORAGE


Handling:

Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and protective clothing, when handling Foamstop 600 N.

Avoid contact with skin, eyes, and clothing. In case of contact, immediately rinse affected areas with plenty of water and remove contaminated clothing.
Use Foamstop 600 N in well-ventilated areas to minimize exposure to vapors and aerosols.
If ventilation is inadequate, use respiratory protection.

Avoid breathing vapors or mists generated during handling.
Use local exhaust ventilation or respiratory protection if exposure cannot be adequately controlled.
Do not eat, drink, or smoke while handling Foamstop 600 N, and wash hands thoroughly after handling to prevent accidental ingestion or exposure.

Follow recommended dosage and application guidelines provided by the manufacturer to achieve effective foam control without overuse or wastage.
Keep Foamstop 600 N containers tightly closed when not in use to prevent contamination and evaporation of active ingredients.
Do not mix Foamstop 600 N with other chemicals unless specified by the manufacturer, as this may affect its effectiveness or stability.


Storage:

Store Foamstop 600 N in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials.
Ensure that storage areas are properly labeled and secured to prevent unauthorized access and accidental spills.
Store Foamstop 600 N away from food, beverages, and feedstuffs to prevent contamination.

Keep containers tightly closed and upright to prevent leakage or spillage.
Ensure that lids are properly sealed to maintain product integrity.
Do not store Foamstop 600 N in containers made of reactive materials such as aluminum, copper, or galvanized steel, as this may lead to chemical reactions or degradation.

Store Foamstop 600 N away from sources of ignition, open flames, and hot surfaces to reduce the risk of fire or explosion.
Keep storage areas clean and free from debris to prevent slips, trips, and falls. Spilled material should be cleaned up promptly and disposed of properly.
Check containers regularly for signs of damage, corrosion, or deterioration.

Damaged containers should be replaced or repaired to prevent leaks or spills.
Store Foamstop 600 N separately from oxidizing agents, acids, alkalis, and strong reducing agents to prevent chemical reactions or contamination.
Keep storage areas well-maintained and in compliance with local regulations and industry standards for the storage of hazardous chemicals.
FOAMSTOP 600N
DESCRIPTION:

Foamstop 600N is a defoaming agent used in the paint and printing ink industries.
Foamstop 600N gives no turbidity or haze and no paint or plating adhesion problems.
Foamstop 600N is Blend of polyalkylene glycols and surface-active components.


Foamstop 600N is a water-soluble defoaming agent.
Foamstop 600N is a blend of polyalkylene glycols and surface-active components.
Foamstop 600N does not give turbidity or haze.

Foamstop 600N exhibits no paint or plating adhesion problems and maintains defoaming properties over a prolonged period of time.
Foamstop 600N is biodegradable and effective over a wide pH range (2 to 12).
Foamstop 600N does not contain mineral oil, amines, nitrates or fluorides.

Foamstop 600N is used in the paint and printing ink applications.
Its use level is 0.05 to 0.5 %wt. on total formulation.

Foamstop 600N is a proprietary blend of Polyalkyleneglycols and surface-active components.
Foamstop 600N is used as a foam control agent in paint, printing ink, and floor polish.
Foamstop 600N is completely soluble in water, biodegradable, effective over a wide pH range, and Foamstop 600N does not contain mineral oil, amines, nitrates, or fluorides.


Foamstop 600N is a water soluble Foam Control agent.
Foamstop 600N is a proprietary blend of Polyalkyleneglycols and surface-active components.
All constituents are EINECS registered and comply with the FDA regulation.





BENEFITS OF FOAMSTOP 600N:
Foamstop 600N is Fully soluble in water; no turbidity or haze of the liquid phase in clear systems
Foamstop 600N Maintains the defoaming properties over a prolonged period of time
Foamstop 600N is Effective over a wide pH range (2 to 12)

Foamstop 600N is Biodegradable
Foamstop 600N Does not contain mineral oil, amines, nitrates or fluorides

APPLICATIONS OF FOAMSTOP 600N:
Foamstop 600N is used in Paint and lacquer industry
Foamstop 600N is used in Printing ink industry
Foamstop 600N is used in Floor polish and cleaner industry

Foamstop 600N is used in Aqueous hydraulic fluids
Foamstop 600N is used in Aqueous metalworking fluids

CHEMICAL AND PHYSICAL PROPERTIES OF FOAMSTOP 600N:
Appearance Light, turbid liquid
Viscosity at 25 ºC Density at 25 ºC 1.02 – 1.06 g/cm3
Flash point >120 ºC
Boiling point polyalkylene glycols >250 ºC
Mineral oil content 0 %
Functions: Defoamer
Chemical Family: Blends & Combinations, Diols, Glycols
End Uses: Waterborne Coating



SAFETY INFORMATION ABOUT FOAMSTOP 600N:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



FOAMSTOP 600N
DESCRTIPTION:
Foamstop 600N is a defoaming agent used in the paint and printing ink industries.
Foamstop 600N gives no turbidity or haze and no paint or plating adhesion problems.
Foamstop 600N is Blend of polyalkylene glycols and surface-active components.



Foamstop 600N is a water-soluble defoaming agent.
Foamstop 600N is a blend of polyalkylene glycols and surface-active components.
Foamstop 600N does not give turbidity or haze.
It exhibits no paint or plating adhesion problems and maintains defoaming properties over a prolonged period of time.

Foamstop 600N is biodegradable and effective over a wide pH range (2 to 12).
Foamstop 600N does not contain mineral oil, amines, nitrates or fluorides.
Foamstop 600N is used in the paint and printing ink applications.
Its use level is 0.05 to 0.5 %wt. on total formulation.





BENEFITS OF FOAMSTOP 600N:
Foamstop 600N is Fully soluble in water; no turbidity or haze of the liquid phase in clear systems
Foamstop 600N Maintains the defoaming properties over a prolonged period of time
Foamstop 600N is Effective over a wide pH range (2 to 12)

Foamstop 600N is Biodegradable
Foamstop 600N Does not contain mineral oil, amines, nitrates or fluorides

Metal surfaces are readily cleaned by rinsing with tap water.
No paint or plating adhesion problems expected when the defoamer is applied


APPLICATIONS OF FOAMSTOP 600N:
FOAMSTOP 600N is used in Paint and lacquer industry
FOAMSTOP 600N is used in Printing ink industry

FOAMSTOP 600N is used in Floor polish and cleaner industry
FOAMSTOP 600N is used in Aqueous hydraulic fluids
FOAMSTOP 600N is used in Aqueous metalworking fluids


CHEMICAL AND PHYSICAL PROPERTIES OF FOAMSTOP 600N:

Appearance Light, turbid liquid
Viscosity at 25 ºC Density at 25 ºC 1.02 – 1.06 g/cm3
Flash point >120 ºC
Boiling point polyalkylene glycols >250 ºC
Mineral oil content 0 %


SAFETY INFORMATION ABOUT FOAMSTOP 600N:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product


FOOD ACID 327
Food acid 327 is a white crystalline salt with formula C6H10CaO6, consisting of two lactate anions H3C(CHOH)CO−2 for each calcium cation Ca2+.
Food acid 327 is a food additive that’s typically added to a wide variety of foods to enhance their texture and flavor or help extend their shelf life.
Food acid 327's E number is E327.

CAS Number: 814-80-2
EC Number: 212-406-7
Molecular Formula: C6H10CaO6
Average mass: 218.218 Da

Food acid 327 is a white crystalline salt with formula C6H10CaO6, consisting of two lactate anions H3C(CHOH)CO−2 for each calcium cation Ca2+.
Food acid 327 forms several hydrates, the most common being the pentahydrate C6H10CaO6·5H2O.

Food acid 327 is used in medicine, mainly to treat calcium deficiencies; and as a food additive with E number of E327.
Some cheese crystals consist of Food acid 327.

Food acid 327 is a food additive that’s typically added to a wide variety of foods to enhance their texture and flavor or help extend their shelf life.
Food acid 327 can also be used as an ingredient in medications or certain types of calcium supplements.

Food acid 327 is a black or white crystalline salt made by the action of lactic acid on calcium carbonate.
Food acid 327 is used in foods (as an ingredient in baking powder) and given medicinally.

Food acid 327's E number is E327.
Food acid 327 is created by the reaction of lactic acid with calcium carbonate or calcium hydroxide.

Food acid 327 is often found in aged cheeses.
Small crystals of Food acid 327 precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.

In medicine, Food acid 327 is most commonly used as an antacid and also to treat calcium deficiencies.
Food acid 327 can be absorbed at various pHs and does not need to be taken with food for absorption for these reasons.

Food acid 327 is added to sugar-free foods to prevent tooth decay.
When added to chewing gum containing xylitol, Food acid 327 increases the remineralization of tooth enamel.
Food acid 327 is also added to fresh-cut fruits such as cantaloupes to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.

Food acid 327 is a calcium salt.
Food acid 327 is a less concentrated form of calcium, and seems to be less bioavailable than other forms of supplemental calcium.

This means Food acid 327 less available to be absorbed and used by your body.
For this reason, Food acid 327 is not the most practical form of oral supplemental calcium.

Food acid 327 is often used as a food additive to enhance the calcium content of foods, replace other salts, or increase the overall pH (that is, decrease the acidity) of the food.

This article looks at the supplement Food acid 327 and what the research says about Food acid 327 health benefits.
Food acid 327 also discusses side effects, dosage, and other calcium supplement options.

Food acid 327 is a salt that consists of two lactate anions for each calcium cation (Ca2+).
Food acid 327 is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide.

Approved by the FDA as a direct food substance affirmed as generally recognized as safe, Food acid 327 is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener.
Food acid 327 is also found in daily dietary supplements as a source of calcium.
Food acid 327 is also available in various hydrate forms, where Food acid 327 pentahydrate is the most common.

Food acid 327 is a dairy-free, vegan tablet that helps maintain healthy bone density.
Food acid 327 is an excellent source of calcium and a good source of magnesium.

The conversion of Food acid 327 into lactic acid is generally done with sulfuric acid, thus resulting in the generation of gypsum (calcium sulfate) as a solid by-product, which, by Food acid 327 accumulation, constitutes an environmental issue.

Food acid 327 is a white or cream, almost odorless food additive derived from lactic acid, a compound that cells naturally create when trying to produce energy in low oxygen conditions.

Food acid 327 produced commercially by neutralizing lactic acid with calcium carbonate or calcium hydroxide and most often used to stabilize, thicken, flavor, firm, or leaven foods.
Food acid 327 is either referred to by Food acid 327 name or E number — E327.

Food acid 327 can also be added to calcium supplements or medications used to treat acid reflux, bone loss, a poorly functioning parathyroid gland, or certain muscle diseases.

Food acid 327 may also be added to animal feed or used to treat water to make Food acid 327 suitable for human consumption.

Despite its similar name, Food acid 327 does not contain lactose.
As such, Food acid 327 safe for people with lactose intolerance.

Food acid 327 is a white crystalline salt made by the action of lactic acid on calcium carbonate.
Food acid 327 is used in foods (as a baking powder) and given medicinally.

Food acid 327 is often found in aged cheeses.
Small crystals of Food acid 327 precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.

In medicine, Food acid 327 is most commonly used as an antacid and also to treat calcium deficiencies.
Food acid 327 can be absorbed at various pHs and does not need to be taken with food for absorption for these reasons.

Food acid 327 is a premium quality product and an extract of Lactic Acid.
Food acid 327 works well in the production of Caviar, pearls, spaghetti and spheres using spherification techniques.

Food acid 327 can also be used to coat fresh fruit and cantaloupes to keep them firm and extend the shelf life.
Food acid 327 a white non-hygroscopic salt and is a recommended source of calcium.

Food acid 327 provides calcium salts in a soluble form to react with Alginate, Gellan or certain kinds of Carrageenan which permit gel formation without heating.
Food acid 327 taste is more discreet than Calcium Chloride (salty and sometimes bitter).

Food acid 327 is recommended for all reactions of inverse spherification and reacts where Alginate and Calcium sources are intimately mixed when in a diffuse setting or full contact gelling.
Food acid 327 also works well in the production of drops, Caviar pearls and all shapes of spaghetti by immersion of an Alginate solution in a Calcium setting bath.
Suitable for Vegans & Vegetarians, Non-GMO, Gluten Free, Kosher Friendly, Halal Friendly.

Food acid 327 is registered under the REACH Regulation but is not currently being manufactured in and / or imported to the European Economic Area.
Food acid 327 is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Food acid 327 contains 20% of the daily recommended value of calcium (from Food acid 327 and stearate) and 12% of the daily recommended value of magnesium.

Food acid 327 is a salt that consists of two lactate anions for each calcium cation (Ca2+).
Food acid 327 is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide.
Approved by the FDA as a direct food substance affirmed as generally recognized as safe, Food acid 327 is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener.

Food acid 327 is also found in daily dietary supplements as a source of calcium.
Food acid 327 is also available in various hydrate forms, where Food acid 327 pentahydrate is the most common.

Food acid 327 is a mineral that is used to treat or prevent low blood calcium levels (hypocalcemia) in people who do not get enough calcium from food.
Food acid 327 is also used in the treatment of conditions such as osteoporosis, disorders of the parathyroid gland, or certain muscle problems.

Food acid 327 may also be used for purposes not listed in this medication guide.

Food acid 327 is commonly used as a food additive in packaged foods, such as:
Nectars,
Jams, jellies, and marmalades,
Butter, margarine, and other types of fats used for cooking or frying,
Canned fruits and vegetables,
Beer.

Food acid 327 sometimes also added to fresh foods, such as mozzarella cheese, fresh pastas, or precut fruit to help them maintain their firmness or extend their shelf life.

You can tell whether a food contains Food acid 327 by looking for Food acid 327 on the ingredient label.
Food acid 327 may also be labeled as E327.

Applications of Food acid 327:
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or doctor.
No supplement is intended to treat, cure, or prevent disease.

Calcium is the most abundant mineral in the body.
Food acid 327 is required for bone health and for heart, muscle, and nerve function.

In the body, blood calcium levels remain relatively consistent and unchanged.
Calcium is acquired from dietary sources.
Apart from calcium for bone health, additional possible benefits of Food acid 327 supplementation include benefits to heart health, oral health, and exercise performance.

Heart Health:
An older study examined the effect of Food acid 327 supplementation on cholesterol in 43 people with hyperlipidemia and previous viral inflammation of the liver.
The study participants were divided into a test group and a control (placebo) group.
The test group was given Food acid 327 and vitamin C three times a day for four weeks.

After four weeks, Food acid 327 was found that the test group had decreased total cholesterol levels by 4%.
Additionally, the supplementation did not cause side effects.
However, there were no statistically significant changes of other cholesterol markers.

This study shows promise for Food acid 327 supplementation on heart health.
However, Food acid 327 was small and used a relatively low dose of Food acid 327.
Additional studies are needed to validate the role of Food acid 327 supplementation in relation to heart health.

Oral Health:
A study looked at whether adding Food acid 327 to xylitol chewing gum helps remineralize lesions on tooth enamel.
Artificial lesions were made on enamel slabs of human extracted teeth and worn by 10 volunteers.
Another 10 were used as controls and stored in a humidifier.

The study participants wore the enamel slabs in one of the following ways:
Without chewing gum
With chewing gum containing xylitol and Food acid 327
With chewing gum containing only xylitol
They did this four times a day for two weeks.

Remineralization was found to be greater after chewing xylitol and Food acid 327 gum than in the other groups.
This led researchers to conclude that Food acid 327 might increase remineralization of tooth enamel surfaces.

A 2014 study looked at the ability of a Food acid 327 pre-rinse to increase fluoride protection against tooth enamel erosion.
The researchers found that the pre-rinse followed by a fluoride rinse significantly decreased surface loss of enamel when used before an erosive challenge.

However, researchers of an earlier study on Food acid 327 pre-rinse found that Food acid 327 did not significantly affect plaque fluoride concentration under any condition.

The mixed results and small sample size of these studies means further research is needed before Food acid 327 can be recommended for oral health.

Pharmaceutical Applications:
Food acid 327 is used as a bioavailability enhancer and nutrient supplement in pharmaceutical formulations.
A spray-dried grade of Food acid 327 pentahydrate has been used as a tablet diluent in direct compression systems, and has been shown to have good compactability.

The properties of the pentahydrate form have been considered superior to those of Food acid 327 trihydrate when used in direct compression tablet formulations.
Tablet properties may be affected by the hydration state of the Food acid 327 and particle size of Food acid 327: reducing particle size increased crushing strength, whereas storage of tablets at elevated temperature resulted in dehydration accompanied by a reduction in crushing strength.

Food acid 327 has also been used as the source of calcium ions in the preparation of calcium alginate microspheres for controlled- release delivery of active agents.
Food acid 327 has been shown to result in lower calcium concentrations in the finished microspheres when compared with calcium acetate.
Therapeutically, Food acid 327 has been used in preparations for the treatment of calcium deficiency.

Uses of Food acid 327:
Food acid 327 is the calcium salt of lactic acid which is soluble in water.
Food acid 327 has a solubility of 3.4 g/100 g of water at 20°c and is very soluble in hot water.

Food acid 327 is available as a monohydrate, trihydrate, and pentahydrate. the trihydrate and pentahydrate have solubili- ties of 9 g in 100 ml of water at 25°c.
Food acid 327 contains approximately 14% calcium.

Food acid 327 is used to stabilize and improve the texture of canned fruits and vegetables by converting the labile pectin to the less solu- ble calcium pectate.
Food acid 327 thereby prevents structural collapse during cooking.

Food acid 327 is used in angel food cake, whipped toppings, and meringues to increase protein extensibility which results in an increase of foam volume.
Food acid 327 is also used in calcium fortified foods such as infant foods and is used to improve the properties of dry milk powder.

Food acid 327 is an oral calcium salt used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diet, patients with osteoporosis, weak bones, decreased parathyroid gland activity.

Food acid 327 is used as a food preservative and calcium supplement.
Food acid 327 is also used in dentifrices, respirator filters, buffering agents, food firming agents, and gelling salts for low methoxypectin.

Food acid 327 is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Food acid 327 may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).

Food acid 327 may also be used in certain patients to make sure they are getting enough calcium (such as women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
Calcium plays a very important role in the body.

Food acid 327 is necessary for normal functioning of nerves, cells, muscle, and bone.
If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones.
Having the right amount of calcium is important for building and keeping strong bones.

Medicine:
Food acid 327 has several uses in human and veterinary medicine.
Food acid 327 is used in medicine as an antacid.

Food acid 327 is also used to treat hypocalcaemia (calcium deficiencies).
Food acid 327 can be absorbed at various pHs, thus Food acid 327 does not need to be taken with food.
However, in this use Food acid 327 has been found to be less convenient than calcium citrate.

In the early 20th century, oral administration of Food acid 327 dissolved in water (but not in milk or tablets) was found to be effective in prevention of tetany in humans and dogs with parathyroid insufficiency or who underwent parathyroidectomy.

Food acid 327 is also found in some mouth washes and toothpaste as an anti-tartar agent.
Food acid 327 (or other calcium salts) is an antidote for soluble fluoride ingestion and hydrofluoric acid.

Food industry:
Food acid 327 is a food additive classified by the United States FDA as Generally Recognized as Safe (GRAS), for uses as a firming agent, a flavor enhancer or flavoring agent, a leavening agent, a nutritional supplement, and a stabilizer and thickener.

Food acid 327 is also known as cheese lactate because Food acid 327 coagulates milk, making the chhena used in the production of paneer cheese.
Chhena is also used to make various sweets and other milk proteins.

Food acid 327 is an ingredient in some baking powders containing sodium acid pyrophosphate.
Food acid 327 provides calcium in order to delay leavening.

Food acid 327 is added to sugar-free foods to prevent tooth decay.
When added to chewing gum containing xylitol, Food acid 327 increases the remineralization of tooth enamel.

Food acid 327 is also added to fresh-cut fruits, such as cantaloupes, to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.

Food acid 327 is used in molecular gastronomy as a flavorless fat-soluble agent for plain and reverse spherification.
Food acid 327 reacts with sodium alginate to form a skin around the food item.

Animal feeds:
Food acid 327 may be added to animal rations as a source of calcium.

Chemistry:
Food acid 327 was formerly an intermediate in the preparation of lactic acid for food and medical uses.
The impure acid from various sources was converted to Food acid 327, purified by crystallization, and then converted back to acid by treatment with sulfuric acid, which precipitated the calcium as calcium sulfate.

This method yielded a purer product than would be obtained by distillation of the original acid.
Recently ammonium lactate has been used as an alternative to calcium in this process.

Water treatment:
Food acid 327 has been considered as a coagulant for removing suspended solids from water, as a renewable, non-toxic, and biodegradable alternative to aluminum chloride AlCl3.

Bioconcrete:
Addition of Food acid 327 substantially increases the compressive strength and reduces water permeability of bioconcrete, by enabling bacteria such as Enterococcus faecalis, Bacillus cohnii, Bacillus pseudofirmus and Sporosarcina pasteurii to produce more calcite.

Consumer Uses:
Food acid 327 is used in the following products: cosmetics and personal care products.
Other release to the environment of Food acid 327 is likely to occur from: indoor use as processing aid.

Widespread uses by professional workers:
Food acid 327 is used in the following products: plant protection products, polishes and waxes and washing & cleaning products.
Food acid 327 is used in the following areas: agriculture, forestry and fishing.
Other release to the environment of Food acid 327 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

Uses at industrial sites:
Food acid 327 is used in the following products: metal surface treatment products, non-metal-surface treatment products and semiconductors.
Food acid 327 is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of Food acid 327 can occur from industrial use: in processing aids at industrial sites and as processing aid.

Features of Food acid 327:

Food acid 327 is a dairy-free, vegan tablet that helps maintain healthy bone density.

Food acid 327 is an excellent source of calcium and a good source of magnesium such as:
Supports muscle and nerve function,
Supports normal functions of cells and cell membranes,

Supports normal blood clotting process,
Supports proper functioning of enzyme systems,

Supports and helps maintain healthy bone density and remodeling,
Provides support in the immune system response function,

Adequate calcium as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life,
Excellent source of calcium,

Good source of magnesium,
Vegan, vegetarian, gluten-free, non-dairy, non-soy.

Food acid 327 for Maintaining Healthy Bone Density:
Bone remodeling (bone turnover) is a continuous cycle of bone breakdown by osteoclasts in areas of the body where bone isn’t needed, and bone rebuilding handled by osteoblasts.
In other words, bone itself undergoes continuous remodeling, with constant resorption and deposition of calcium into new bone.
The balance between bone resorption and deposition is important for healthy bones, and Food acid 327 changes with age.

Both calcium and magnesium are critical to bone health.
99% of the body’s calcium supply is stored in the bones and teeth where Food acid 327 supports normal and healthy bone structure and function.
Taking an additional calcium supplement can help increase the body’s supply of calcium.

Magnesium also contributes to the structural development of bone, with 50% to 60% present in the bones.
In particular, magnesium is involved in bone formation and influences the activities of osteoblasts (bone rebuilding) and osteoclasts (bone breakdown).

Food acid 327 for Immune System Health:
Both calcium and magnesium are involved in supporting aspects of the body’s healthy immune system.
Calcium (Ca2+) signals control various aspects of cell functioning such as T lymphocytes.

T lymphocytes – along with other immune cells – respond to foreign particles in the body.
These T cells, which are made in bone marrow and are essential for cell-mediated immunity, need a sustained Calcium ion flow for regulation, activation, and proliferation.

Emerging research indicates magnesium may also play a role in the human immune system response such as through magnesium transporters.
A number of magnesium transporters have been identified in immune cells such as Magnesium transporter 1 (MagT1).
MagT1 is expressed in the spleen, thymus, T and B lymphocytes, suggesting that MagT1 may be involved in the human immune system functions.

Benefits of Food acid 327:

Possible Health Benefits:
Very few studies have specifically researched the health benefits of Food acid 327.

That said, Food acid 327 can be used as a main source of calcium in calcium supplements, and some studies link calcium-rich diets to stronger and healthier bones, though research is inconsistent.
Though sourcing your calcium directly from foods remains the best way to ingest this mineral, supplements can be a helpful tool for those who are unable to get enough calcium through their diet alone.

When consumed as a supplement, Food acid 327 may provide benefits similar to those associated with other calcium supplements, including:
Stronger bones.
When taken together with vitamin D, calcium supplements are thought to contribute to the development and maintenance of strong, healthy bones.

Reduced blood pressure.
Calcium-rich diets may help slightly lower systolic blood pressure (the top number) in those with elevated blood pressure.

However, there seems to be little benefit among people with normal blood pressure levels.
Protection against preeclampsia.

High calcium intakes during pregnancy may lower the risk of preeclampsia, a serious complication that affects up to 14% of pregnancies worldwide.
Protection against colon cancer.

Studies suggest that a high calcium intake from foods or supplements may reduce colon cancer risk.
Still, more research is needed to confirm these findings.

Older studies further suggest that chewing gums containing Food acid 327 together with the artificial sweetener xylitol may help protect against cavities.
Yet, more research is needed to confirm these results.

Gram per gram, Food acid 327 tends to provide smaller amounts of calcium than more popular forms of calcium, such as calcium carbonate and calcium citrate.

Therefore, to contain equivalent amounts of calcium, Food acid 327 supplements may be larger than other types of calcium supplements, potentially making them harder to swallow.
You may also need to take more pills.

Food acid 327 is likely less constipating than calcium carbonate, but Food acid 327 doesn’t provide any additional benefits beyond those associated with calcium citrate.
This explains why Food acid 327 seldom used as a main ingredient in calcium supplements.

Typical Properties of Food acid 327:
The lactate ion is chiral, with two enantiomers, D (−,R) and L (+,S).
The L isomer is the one normally synthesized and metabolized by living organisms, but some bacteria can produce the D form or convert the L to D.
Thus Food acid 327 also has D and L isomers, where all anions are of the same type.

Some synthesis processes yield a mixture of the two in equal parts, resulting in the DL (racemic) salt.
Both the L and the DL forms occur as crystals on the surface of aging Cheddar cheese.

The solubility of calcium L-lactate in water increases significantly in presence of d-gluconate ions, from 6.7 g/dl) at 25 °C to 9.74 g/dl or more.
Paradoxically, while the solubility of calcium L-lactate increases with temperature from 10 °C (4.8 g/dl) to 30 °C (8.5 g/dl), the concentration of free Ca2+ ions decreases by almost one half.
This is explained as the lactate and calcium ions becoming less hydrated and forming a complex C3H5O3Ca+.

The DL (racemic) form of the salt is much less soluble in water than the pure L or D isomers, so that a solution that contains as little as 25% of the D form will deposit racemic DL-lactate crystals instead of L-lactate.

The pentahydrate loses water in a dry atmosphere between 35 and 135 °C, being reduced to the anhydrous form and losing Food acid 327 crystalline character.
The process is reversed at 25 °C and 75% relative humidity.

Pharmacodynamics of Food acid 327:
Both components of Food acid 327, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively.

Mechanism of action of Food acid 327:
In aqueous environments such as the gastrointestinal (GI) tract, Food acid 327 will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid.
Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways.
Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis.

Absorption of Food acid 327:
In order to be absorbed, calcium must be in Food acid 327 freely soluble form (Ca2+) or bound to a soluble organic molecule.
Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins.
The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport.

Preparation of Food acid 327:
Food acid 327 can be prepared by the reaction of lactic acid with calcium carbonate or calcium hydroxide.

Since the 19th century, the salt has been obtained industrially by fermentation of carbohydrates in the presence of calcium mineral sources such as calcium carbonate or calcium hydroxide.
Fermentation may produce either D or L lactate, or a racemic mixture of both, depending on the type of organism used.

General Manufacturing Information of Food acid 327:

Industry Processing Sectors:
Wholesale and Retail Trade

Handling and storage of Food acid 327:

Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures:
General industrial hygiene practice.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.

Storage class:
Storage class (TRGS 510): 11: Combustible Solids

Stability and reactivity of Food acid 327:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

Incompatible materials:
Strong oxidizing agents

Safety and Precautions of Food acid 327:
According to the Food and Drug Administration (FDA), Food acid 327 is generally recognized as safe (GRAS) and may be added to all foods except infant foods and formulas.

Food acid 327 is considered a safe source of calcium in calcium supplements.
In addition, given that Food acid 327 contains less calcium than other forms, Food acid 327 less likely to cause the constipation or upset stomach commonly associated with supplements containing calcium carbonate.

That said, Food acid 327 important to note that excess intakes of Food acid 327 may result in hypercalcemia, a condition characterized by dangerously high blood levels of calcium, which may cause heart or kidney problems.

Food acid 327 best to not exceed the safe daily upper intake levels (UL) of 2,500 mg per day for adults under 50 years old and pregnant or breastfeeding people, 2,000 mg per day for those 51 years or older, and 3,000 mg per day for pregnant or breastfeeding people younger than 19.

Food acid 327 supplements may also interact with some medications, including diuretics, antibiotics, and anti-seizure drugs.
Therefore, Food acid 327 best to seek guidance from your healthcare provider before taking such supplements.

First aid measures of Food acid 327:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.

In case of skin contact:
Wash off with soap and plenty of water.

In case of eye contact:
Flush eyes with water as a precaution.

If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.

Firefighting measures of Food acid 327:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from Food acid 327 or mixture:
Carbon oxides
Calcium oxide

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

Further information:
No data available

Accidental release measures of Food acid 327:

Personal precautions, protective equipment and emergency procedures:
Avoid dust formation.
Avoid breathing vapors, mist or gas.

Environmental precautions:
No special environmental precautions required.

Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Identifiers of Food acid 327:
CAS Number: 814-80-2
ChEMBL: ChEMBL2106111
ChemSpider: 12592
DrugBank: DB13231
ECHA InfoCard: 100.011.278
EC Number: 212-406-7
E number: E327 (antioxidants, ...)
PubChem CID: 13144
UNII: 2URQ2N32W3
CompTox Dashboard (EPA): DTXSID0020236
InChI: InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
Key: MKJXYGKVIBWPFZ-UHFFFAOYSA-L
InChI=1/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
Key: MKJXYGKVIBWPFZ-NUQVWONBAM
SMILES: [Ca+2].[O-]C(=O)C(O)C.[O-]C(=O)C(O)C

CAS number: 5743-47-5
EC number: 248-953-3
Grade: Ph Eur,BP,USP,E 327
Hill Formula: C₆H₁₀CaO₆*5H₂O
Molar Mass: 308.30 g/mol
HS Code: 2918 11 00

Molecular Formula: C6H10CaO6
Average mass: 218.218 Da
Monoisotopic mass: 218.010330 Da
ChemSpider ID: 12592

Properties of Food acid 327:
Chemical formula: C6H10CaO6
Molar mass: 218.22 g/mol
Appearance: white or off-white powder, slightly efflorescent
Density: 1.494 g/cm3
Melting point: 240 °C (464 °F; 513 K) (anhydrous)
120 °C (pentahydrate)
Solubility in water: L-lactate, anhydrous, g/100 mL: 4.8 (10 °C), 5.8 (20 °C), 6.7 (25 °C), 8.5 (30 °C); 7.9 g/100 mL (30 °C)
Solubility: very soluble in methanol, insoluble in ethanol
Acidity (pKa): 6.0-8.5
Refractive index (nD): 1.470

Ignition temperature: 610 °C
Melting Point: 240 °C
pH value: 7 (50 g/l, H₂O, 20 °C)
Bulk density: 300 - 500 kg/m3
Solubility: 50 g/l

Molecular Weight: 218.22 g/mol
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 0
Exact Mass: 218.0103289 g/mol
Monoisotopic Mass: 218.0103289 g/mol
Topological Polar Surface Area: 121Ų
Heavy Atom Count: 13
Complexity: 53.5
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

Specifications of Food acid 327:
Assay (complexometric; calculated on dried substance): 98.0 - 101.0 %
Identity (IR-spectrum): passes test
Identity (Calcium): passes test
Identity (Lactat): passes test
Appearance: white to almost white crystalline or granular powder
Appearance of solution (71 g/l; water): almost clear (≤ 6 NTU) and not more intense in colour than reference solution BY₆
Acidity or alkalinity: passes test
pH (71 g/l; water): 6.0 - 8.0
Chloride (Cl): ≤ 200 ppm
Fluoride (F): ≤ 30 ppm
Sulfate (SO₄): ≤ 400 ppm
Heavy metals (as Pb): ≤ 10 ppm
Al (Aluminium): ≤ 50 ppm
As (Arsenic): ≤ 3 ppm
Ba (Barium)*: ≤ 70 ppm
Fe (Iron): ≤ 50 ppm
Hg (Mercury): ≤ 1 ppm
Pb (Lead): ≤ 2 ppm
Magnesium and alcali salts: ≤ 1.0 %
Volatile fatty acids: passes test
Reducing substances: passes test
Residual solvents (ICH Q3C): excluded by production process
Loss on drying (125 °C): 22.0 - 27.0 %

Names of Food acid 327:

Regulatory process names:
Calcium lactate
Calcium lactate
calcium lactate

IUPAC names:
calcium bis(2-hydroxypropanoate)

Preferred IUPAC name:
Calcium bis(2-hydroxypropanoate)

Other names:
calcium lactate 5-hydrate,
calcium lactate,
2-hydroxypropanoic acid
calcium salt pentahydrate

Other identifiers:
5743-48-6

Synonyms of Food acid 327:
calcium lactate
814-80-2
Calphosan
Calcium dilactate
calcium 2-hydroxypropanoate
Hemicalcium L-lactate
Conclyte calcium
Lactic acid, calcium salt (2:1)
2-Hydroxypropanoic acid calcium salt
63690-56-2
calcium;2-hydroxypropanoate
Propanoic acid, 2-hydroxy-, calcium salt (2:1)
Calcium lactate anhydrous
Calcium 2-hydroxypropanoate (1:2)
5743-48-6
Calcium Lactate [USAN:JAN]
CCRIS 3669
HSDB 976
Calcium (as lactate)
calcium bis(2-hydroxypropanoate)
EINECS 212-406-7
Calcium lactate, anhydrous
Ins No.327
UNII-2URQ2N32W3
AI3-04468
2URQ2N32W3
28305-25-1
CALCIUM LACTATE (1 G)
DTXSID0020236
INS-327
INS-327-
EINECS 227-266-2
Calcium lactate [II]
Calcium lactate [MI]
Calcium lactate [FCC]
Calcium lactate [HSDB]
Calcium lactate [INCI]
Calcium lactate (1:2)
Calcium lactate [VANDF]
E-327
EC 212-406-7
Calcium lactate [WHO-DD]
DTXCID60236
Calcium (as lactate) [VANDF]
Ca lactate
C3H6O3.1/2Ca
Calcium (S)-2-hydroxy-propanate
CAS-814-80-2
(+/-)-Lactic acid, calcium salt (2:1)
calcium dl-lactate
C3-H6-O3.1/2Ca
L(+)-calcium lactate
Propanoic acid, 2-hydroxy-, calcium salt
C3H6O3.xCa
Lactic acid, calcium salt
SCHEMBL4319
C3-H6-O3.x-Ca
CHEMBL2106111
HY-B2227A
CALCIUM LACTATE [USP-RS]
Lactic acid calcium salt (2:1)
MKJXYGKVIBWPFZ-UHFFFAOYSA-L
AMY37027
Tox21_201378
Tox21_302896
Bis(2-hydroxypropanoic acid) calcium
AKOS015837558
CALCIUM LACTATE [EP MONOGRAPH]
DB13231
LS-2396
NCGC00256365-01
NCGC00258929-01
LS-192480
2-Hydroxypropanoic acid calcium salt (2:1)
CS-0021602
FT-0623403
FT-0652809
F16480
CALCIUM LACTATE ANHYDROUS [USP MONOGRAPH]
CALCIUM LACTATE, ANHYDROUS [EP IMPURITY]
A840142
Propanoic acid, 2-hydroxy-, calcium salt (2;1)
Q419693
227-266-2 [EINECS]
2URQ2N32W3
5743-48-6 [RN]
814-80-2 [RN]
Bis(2-hydroxypropanoate) de calcium [French] [ACD/IUPAC Name]
Calcium bis(2-hydroxypropanoate) [ACD/IUPAC Name]
Calcium dilactate
CALCIUM D-LACTATE
Calcium lactate [JP15] [Trade name] [USP]
CALCIUM LACTATE, L-
Calciumbis(2-hydroxypropanoat) [German] [ACD/IUPAC Name]
Propanoic acid, 2-hydroxy-, calcium salt (2:1) [ACD/Index Name]
[(2-HYDROXYPROPANOYL)OXY]CALCIO 2-HYDROXYPROPANOATE
[28305-25-1] [RN]
145179-24-4 [RN]
16127-59-6 [RN]
240-289-2 [EINECS]
28305-25-1 [RN]
2-Hydroxypropanoic acid calcium salt
3-imidazo[1,2-a]pyrazinecarboxaldehyde
5497-50-7 [RN]
5743-47-5 [RN]
63690-56-2 [RN]
Calcet
CALCIUM (S)-2-HYDROXYPROPIONATE
calcium 2-hydroxypropanoate
Calcium 2-hydroxypropanoate (1:2)
calcium and 2-hydroxypropanoate
Calcium Lactate [USAN:JAN] [JAN] [USAN]
CALCIUM LACTATE, ANHYDROUS
calciumlactate
Calphosan
Conclyte calcium
Hemicalcium L-lactate
Imidazo[1,2-a]pyrazine-3-carbaldehyde [ACD/IUPAC Name]
lactic acid calcium salt
Lactic Acid Calcium Salt (2:1)
MFCD00035548
MFCD00065401
MFCD00078198
UNII:2URQ2N32W3
FOOD ADDITIVE E331
Food additive E331 appears as a white crystalline powder or granular crystals and, given Food additive E331 is a salt, possesses a salty / saline taste with no real detectable odour.
Food additive E331 is a chemical compound, the sodium salt of Citric Acid.
Food additive E331 is obtained by reacting Sodium Citrate with sodium hydroxide, carbonate, or bicarbonate and then crystallized and dehydrated.

CAS Number: 68-04-2
EC number: 200-675-3
Chemical Formula: Na3C6H5O7
Molar Mass: 294.10 g/mol

Food additive E331 has the chemical formula of Na3C6H5O7.
Food additive E331 is sometimes referred to simply as "sodium citrate", though Food additive E331 can refer to any of the three sodium salts of citric acid.
Food additive E331 possesses a saline, mildly tart flavor, and is a mild alkali.

Food additive E331 is mildly basic and can be used along with Sodium Citrate to make biologically compatible buffers.

Food additive E331 has the chemical formula Na3C6H5O7.
Food additive E331 can refer to any of the three sodium salts of citric acid.

Food additive E331 is lightweight and can be used with Sodium Citrate to make biocompatible buffers.

Food additive E331, one of the sodium salts of citric acid, is a compound found in every living organism and is part of key metabolic pathways in all body cells.
Food additive E331 is found in high concentrations in sour fruits, kiwis, strawberries and many other fruits.
Food additive E331 is commercially prepared by the fermentation of molasses by the mold Aspergillus niger.

Food additive E331, also referred to as Sodium Citrate, Trisodium Salt or Trisodium citrate, is the tribasic salt of citric acid.
Food additive E331 appears as a white crystalline powder or granular crystals and, given Food additive E331 is a salt, possesses a salty / saline taste with no real detectable odour.

Food additive E331 has the CAS number 6132-04-3 and formula Na3C6H5O7.
Food additive E331 is water-soluble, non-toxic and fully biodegradable.

Food additive E331 is the sodium salt of citric acid.
Food additive E331 is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol.

Like Sodium Citrate, Food additive E331 has a sour taste.
From the medical point of view, Food additive E331 is used as alkalinizing agent.

Food additive E331 works by neutralizing excess acid in the blood and urine.
Food additive E331 has been indicated for the treatment of metabolic acidosis.

Food additive E331 is a chemical compound, the sodium salt of Citric Acid.
Food additive E331 is obtained by reacting Sodium Citrate with sodium hydroxide, carbonate, or bicarbonate and then crystallized and dehydrated.

Food additive E331 also occurs naturally in citrus fruits.
Food additive E331 is commonly referred to as ‘Sodium Citrate’, but this term is ambiguous as Food additive E331 can also refer to the sodium or monosodium salt.

Food additive E331 is structured in such a way that a sodium atom is attached to each of the three carboxyl groups present.
Similarly, Monosodium Citrate is a chemical compound with one sodium in the molecule and Disodium Citrate is a chemical compound with two sodium atoms.

Food additive E331 is labeled as a food additive with the symbol E331.

Food additive E331 is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Food additive E331 is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Food additive E331 is a tribasic salt of citric acid.
Food additive E331 is produced by complete neutralisation of citric acid with high purity sodium hydroxide or carbonate and subsequent crystallisation and dehydration.
The common hydrate form, Food additive E331 dihydrate, is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent.

Food additive E331 anhydrous is manufactured from Food additive E331 dihydrate.
Water molecules of the dihydrate crystals are removed by a patented process without destroying the original crystal matrix.

The resulting crystals have a porous matrix that can be used as a carrier for inorganic and/or organic substances like perfumes and surfactants.
Due to Food additive E331 low water content Food additive E331 anhydrous does not add water to the formulation.

Food additive E331 has even the excellent ability to take up surplus water from moisture sensitive formulations thus providing better shelf life to the end product.
Therefore, Food additive E331 anhydrous finds Food additive E331 particular uses in water sensitive formulations like instant drinks as well as tablets and powders in pharmaceuticals and detergents.

Food additive E331 anhydrous occurs as white, granular crystals or as white, crystalline powder.
Food additive E331 is freely soluble in water and practically insoluble in ethanol (96 %).

Food additive E331 is a non-toxic, neutral salt with low reactivity.
Food additive E331 is chemically stable if stored at ambient temperatures.
Food additive E331 anhydrous is fully biodegradable and can be disposed of with regular waste or sewage.

Food additive E331 dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent.
Food additive E331 used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators.

Food additive E331 dihydrate is a tribasic salt of citric acid.
Food additive E331 is produced by complete neutralisation of Food additive E331 with high purity sodium hydroxide or carbonate and subsequent crystallisation.
Food additive E331 dihydrate is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent.

Food additive E331 dihydrate occurs as white, granular crystals or as white, crystalline powder with a pleasant, salty taste.
Food additive E331 is slightly deliquescent in moist air, freely soluble in water and practically insoluble in ethanol (96 %).

Food additive E331 dihydrate is a non-toxic, neutral salt with low reactivity.
Food additive E331 is chemically stable if stored at ambient temperatures.
Food additive E331 dihydrate is fully biodegradable and can be disposed of with regular waste or sewage.

Food additive E331 in Food:
Food additive E331 is a food additive with the E number E331.
Food additive E331 is used in a variety of processed food and drink primarily as a flavour enhancer and a preservative.
As an emulsifying agent Food additive E331 is also used in cheesemaking to allow cheese to melt without the separation of oils and fats.

Food additive E331 in food buffers pH levels to help regulate acidity in a variety of foods to balance taste and is also able to impart a tart / sour flavour in a wide variety of drink products.

Usage areas of Food additive E331:
Food additive E331 is often used as a food additive as a flavoring or preservative.
The E number is E331.

Food additive E331 is used as a flavoring agent in certain varieties of club soda.
Food additive E331 is common as an ingredient in Bratwurst and is also commercially available for drinks and beverage mixes, contributing a tart flavor.

Food additive E331 is found in gelatin mix, ice cream, jam, desserts, powdered milk, processed cheeses, sodas and wine.
Food additive E331 can be used as an emulsifier when making cheese.
Food additive E331 allows the cheese to melt without remaining greasy.

Food additive E331, a conjugate base of a weak acid, can act as a buffering agent or acidity regulator by resisting change in pH.
Food additive E331 is used to control the acidity of some substances, such as gelatin desserts.

Food additive E331 is found in mini milk containers used in coffee machines.
Food additive E331 is a particularly effective substance for removing carbonate scale from boilers without cracking and for cleaning car radiators.

Uses of Food additive E331:
Food additive E331 has many uses, but is mainly applied in the food industry.
Food additive E331 has similar applications as Citric Acid, so Food additive E331 is usually used as a flavor enhancer, to acidify foods or beverages, or as a preservative.

Food additive E331 is also commonly used in medicine as a drug ingredient, usually for people with urinary tract infections.
Food additive E331 also plays a role as an anticoagulant, which means Food additive E331 inhibits blood clotting.

In addition, Food additive E331 is used in chemistry.
Food additive E331 is a component of buffers and a component of Benedict’s reagent, which is used to detect sugars and aldehydes.
Food additive E331 is also found in cosmetics such as shower gels, shampoos or skin creams, as Food additive E331 gives them the right acidity level and is used as a preservative.

Another application of Food additive E331 is to remove scale from boilers, clean car radiators, and burnt sheet metal or pots.
Food additive E331 is also used in the production of cleaning products, as it softens water, allowing detergents to work more effectively.

Food additive E331 is used in similar applications to citric acid.
These uses include as an acidity regulator in food and drink, as a sequestering agent to prevent limescale inference with soaps and detergents and as an emulsifying agent to aid chemical mixing processes where two separate elements are incapable of mixing (for example oil and water) and helps to keep these mixtures stable once formulated.

Food additive E331 is used in blood collection (anticoagulant), photography, and food production. (sequestering agent, emulsifier, and acidulant)
Permitted for use as an inert ingredient in non-food pesticide products.

Food additive E331 in food industry:

Foods:
Food additive E331 is chiefly used as a food additive, usually for flavor or as a preservative.
Food additive E331 E number is E331.

Food additive E331 is employed as a flavoring agent in certain varieties of club soda.
Food additive E331 is common as an ingredient in bratwurst, and is also used in commercial ready-to-drink beverages and drink mixes, contributing a tart flavor.
Food additive E331 is found in gelatin mix[clarification needed], ice cream, yogurt, jams, sweets, milk powder, processed cheeses, carbonated beverages, and wine[citation needed], amongst others.

As a conjugate base of a weak acid, citrate can perform as a buffering agent or acidity regulator, resisting changes in pH.
Food additive E331 is used to control acidity in some substances, such as gelatin desserts.

Food additive E331 can be found in the milk minicontainers used with coffee machines.
Food additive E331 is the product of antacids, such as Alka-Seltzer, when they are dissolved in water.

The pH of a solution of 5 g/100 ml water at 25 °C is 7.5 – 9.0.
Food additive E331 is added to many commercially packaged dairy products to control the PH impact of the gastrointestinal system of humans, mainly in processed products such as cheese and yogurt.

Food additive E331 can be used to optimize the safety and quality of snacks, cereals, bakery products and potato products such as French fries without affecting the production process.

Food additive E331 is found in carbonated beverages, dairy products, confectionery, prepared foods, canned meats and vegetables, margarine, mustard, sauces, mayonnaise, spices, jams, and much more.
This is not surprising, because Food additive E331 has various properties that are important for the food industry.

Firstly, Food additive E331 is used as an acidity regulator to maintain the proper pH of Food additive E331.
Food additive E331 is found in sodas, especially those with lemon flavor, energy drinks, desserts or jams.

Food additive E331 is a sequestering agent, which means Food additive E331 is a substance that binds metal ions, called chelates.
Thanks to this, the consumer is protected from the harmful effects of heavy metals in foods.

Food additive E331 is also an emulsifier – Food additive E331 enables the preparation of a uniform solution from two immiscible liquids.
Food additive E331 is useful, for example, in the production of cheese, as Food additive E331 does not become greasy after melting, because Food additive E331 prevents the separation of fats.

Another use of Food additive E331 in the food industry is as a preservative.
Food additive E331 protects the fats in Food additive E331 from oxidation and rancidity.
Food additive E331 also prevents color changes in foods.

Medical uses:
In 1914, the Belgian doctor Albert Hustin and the Argentine physician and researcher Luis Agote successfully used Food additive E331 as an anticoagulant in blood transfusions, with Richard Lewisohn determining Food additive E331 correct concentration in 1915.
Food additive E331 continues to be used today in blood-collection tubes and for the preservation of blood in blood banks.

The citrate ion chelates calcium ions in the blood by forming calcium citrate complexes, disrupting the blood clotting mechanism.
Recently, Food additive E331 has also been used as a locking agent in vascath and haemodialysis lines instead of heparin due to Food additive E331 lower risk of systemic anticoagulation.

In 2003, Ööpik et al. showed the use of Food additive E331 (0.5 g/kg body weight) improved running performance over 5 km by 30 seconds.

Food additive E331 is used to relieve discomfort in urinary-tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative.
Food additive E331 is a major component of the WHO oral rehydration solution.

Food additive E331 is used as an antacid, especially prior to anaesthesia, for caesarian section procedures to reduce the risks associated with the aspiration of gastric contents.

Food additive E331 in medicine:
Food additive E331 is not only known as a food additive, but also as an important chemical compound in medicine.
Food additive E331 is used in analytical laboratories where blood tests are performed because Food additive E331 has an anticoagulant effect.

This prevents blood cells from clumping together.
Food additive E331 is then used as a component of solutions for filling hemodialysis catheters.

Food additive E331 lowers the concentration of heparin, which in turn reduces the risks associated with coagulation disorders in patients with kidney disease or blood clotting.
This counteracts side effects during and after dialysis treatment.
This effect is also extremely useful when storing blood or during transfusions.

Food additive E331 is also used as a drug.
Food additive E331 treats kidney stones, gout and reduces the symptoms of metabolic acidosis.

Food additive E331 can also be used as a laxative.
Food additive E331 can be used for hypercalcemia, a condition in which the concentration of calcium in the blood is too high.
Food additive E331 works by increasing the excretion of calcium through the urine.

Consumer Uses:
Food additive E331 is used in the following products: washing & cleaning products, polishes and waxes, air care products, cosmetics and personal care products, water softeners, perfumes and fragrances, water treatment chemicals, coating products, inks and toners, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products), fertilisers, adsorbents, fillers, putties, plasters, modelling clay, laboratory chemicals and photo-chemicals.
Other release to the environment of Food additive E331 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

Widespread uses by professional workers:
Food additive E331 is used in the following products: laboratory chemicals, washing & cleaning products, air care products, perfumes and fragrances, polishes and waxes, water softeners, water treatment chemicals, biocides (e.g. disinfectants, pest control products), coating products, fillers, putties, plasters, modelling clay, inks and toners, textile treatment products and dyes, fertilisers, photo-chemicals, cosmetics and personal care products and adsorbents.
Food additive E331 is used in the following areas: health services, building & construction work, mining, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.
Food additive E331 is used for the manufacture of: machinery and vehicles and furniture.

Other release to the environment of Food additive E331 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Uses at industrial sites:
Food additive E331 is used in the following products: pH regulators and water treatment products, washing & cleaning products, polishes and waxes and water treatment chemicals.
Food additive E331 is used in the following areas: mining, health services and building & construction work.
Food additive E331 is used for the manufacture of: machinery and vehicles, textile, leather or fur, metals, fabricated metal products, electrical, electronic and optical equipment and chemicals.

Release to the environment of Food additive E331 can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as processing aid, formulation of mixtures and in the production of articles.
Other release to the environment of Food additive E331 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Other Uses:

Food:
Baby Food, Infant Formula
Bakery
Cereals, Snacks
Confectionery
Dairy
Dairy Alternatives
Desserts, Ice Cream
Flavours
Fruit Preparations, Sweet Spreads
Fruits, Vegetables
Meat Alternatives
Meat, Seafood
Plant-based Products
Ready Meals, Instant Food
Sauces, Dressings, Seasonings

Beverages:
Alcoholic Beverages
Carbonated Soft Drinks
Instant Drinks, Syrups
Juice Drinks
Plant-based
RTD Tea and Coffee
Sports and Energy Drinks
Waters

Healthcare:
Clinical Nutrition
Medical Devices
OTC, Food Supplements
Pharmaceutical Products

Personal Care:
Colour Cosmetics
Fragrances
Hair Care
Oral Care
Skin Care
Soap and Bath Products

Cleaners & Detergents:
Dish Washing
Industrial Cleaners
Laundry Care
Surface Care

Industrial Applications:
Adhesives, Sealants
Agrochemicals, Fertilisers
Construction
Fine Chemicals
Inks, Paints, Coatings
Oil Drilling
Paper
Plastics, Polymers
Textile, Leather

Feed & Pet Food:
Feed
Pet Food

Pharma:
Buffering agent
Chelating agent
Mineral source

Industrial Processes with risk of exposure:
Photographic Processing

Applications of Food additive E331:
Food additive E331 dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent.
Food additive E331 used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators.

Foods:
Food additive E331 is chiefly used as a food additive, usually for flavor or as a preservative.
Food additive E331 E number is E331.

Food additive E331 is employed as a flavoring agent in certain varieties of club soda.
Food additive E331 is common as an ingredient in bratwurst, and is also used in commercial ready-to-drink beverages and drink mixes, contributing a tart flavor.
Food additive E331 is found in gelatin mix, ice cream, yogurt, jams, sweets, milk powder, processed cheeses, carbonated beverages, and wine,[3] amongst others.

Food additive E331 can be used as an emulsifying stabilizer when making cheese.
Food additive E331 allows the cheese to melt without becoming greasy by stopping the fats from separating.

Buffering:
As a conjugate base of a weak acid, citrate can perform as a buffering agent or acidity regulator, resisting changes in pH.
Food additive E331 is used to control acidity in some substances, such as gelatin desserts.

Food additive E331 can be found in the milk minicontainers used with coffee machines.
Food additive E331 is the product of antacids, such as Alka-Seltzer, when they are dissolved in water.

The pH of a solution of 5 g/100 ml water at 25 °C is 7.5 – 9.0.
Food additive E331 is added to many commercially packaged dairy products to control the pH impact of the gastrointestinal system of humans, mainly in processed products such as cheese and yogurt, although Food additive E331 also has beneficial effects on the physical gel microstructure.

Chemistry:
Food additive E331 is a component in Benedict's qualitative solution, often used in organic analysis to detect the presence of reducing sugars such as glucose.

Medicine:
In 1914, the Belgian doctor Albert Hustin and the Argentine physician and researcher Luis Agote successfully used Food additive E331 as an anticoagulant in blood transfusions, with Richard Lewisohn determining Food additive E331 correct concentration in 1915.
Food additive E331 continues to be used today in blood-collection tubes and for the preservation of blood in blood banks.

The citrate ion chelates calcium ions in the blood by forming calcium citrate complexes, disrupting the blood clotting mechanism.
Recently, Food additive E331 has also been used as a locking agent in vascath and haemodialysis lines instead of heparin due to Food additive E331 lower risk of systemic anticoagulation.

In 2003, Ööpik et al. showed the use of Food additive E331 (0.5 g/kg body weight) improved running performance over 5 km by 30 seconds.

Food additive E331 is used to relieve discomfort in urinary-tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative.
Food additive E331 is a major component of the WHO oral rehydration solution.

Food additive E331 is used as an antacid, especially prior to anaesthesia, for caesarian section procedures to reduce the risks associated with the aspiration of gastric contents.

Boiler descaling:
Food additive E331 is a particularly effective agent for removal of carbonate scale from boilers without removing them from operation and for cleaning automobile radiators.

Healthcare:

Effervescent tablets and preparations:
The reaction of citric acid and bicarbonate liberates carbon dioxide, which aids the dissolution of active ingredients and improves palatability.
Effervescent systems are widely used in denture-cleaning products, as well as pain relief and vitamin tablets.

Pharmaceutically active substances — many are supplied as their citrate salt.

pH control:
Citric acid, with sodium or potassium citrate, is an efficient buffering system used in a variety of pharmaceutical and cosmetic applications for improving stability and (where appropriate) enhancing the activity of preservatives.

Flavor:
The sharp, acid taste of citric acid (which is often used to enhance fruit flavors) can help mask the unpleasant, medicinal taste of pharmaceuticals.

Antioxidant:
The citrate ion is a powerful chelating agent for trace metal ions.

Blood anticoagulant:
The citrate ion will chelate calcium, thereby reducing the tendency for blood to clot.

Diuretic – potassium citrate has diuretic properties.
Clinical Nutrition Medical Devices
OTC, Food Supplements Pharmaceutical Products
Color Cosmetics Deodorants
Fragrances Hair Care
Oral Care Skin Care Soap and Bath Products

Cleaners & Detergents:
The major components of cleaning products are surfactants and builders.
Other ingredients are added to provide a variety of functions, e.g., increasing cleaning performance for specific soils/surfaces, ensuring product stability, and supplying a unique identity to a product.

Complex phosphates and Food additive E331 are common sequestering builders.
Builders enhance or maintain the cleaning efficiency of the surfactant.

The primary function of builders is to reduce water hardness.
This is done either by sequestration or chelation (holding hardness minerals in solution); by precipitation (forming an insoluble substance); or by ion exchange (trading electrically charged particles).
Builders can also supply and maintain alkalinity, which assists cleaning, especially of acid soils; help keep removed soil from redepositing during washing, and emulsify oily and greasy soils.

Dish Washing Industrial Cleaners:

Laundry Care Surface Care:

Industrial
Sodium Citrate is employed as an industrial cleaner to clear steam blocks and hot water systems of calcium and rust layers.
As a chemical polish, Sodium Citrate is used to treat aluminum, copper and other metal surfaces.

Sodium Citrate and citrates are used as buffering and complexing agents in electro-plating baths.
The building and textile industries also take advantage of Sodium Citrate’s outstanding chelating ability as well as Food additive E331 non-toxicity.

Examples include set retarding of gypsum plasters and textile finishing.
Further industrial applications of Sodium Citrate and citrates range from desulphurisation of flue gas and oil recovery to the decontamination of radioactive nuclear reactor materials.

Adhesives, Sealants, Agrochemicals, Fertilizers
Construction, Fine Chemicals
Inks, Paints, Coatings, Metal Surface Treatment
Oil Drilling Ore Mining and Refining
Paper, Plastics, Polymers
Textile, Leather

Main Functions of Food additive E331:
pH regulator
Chelating agent
Buffering agent
Flavour enhancer
Stabiliser
Emulsifying agent

Properties of Food additive E331:
Food additive E331 is in the form of a white, odorless powder with a slightly salty taste.
Food additive E331 occurs as a hydrate in combination with water.

Food additive E331 is characterized by the fact that Food additive E331 is hygroscopic, so Food additive E331 easily absorbs and combines with water.
Therefore, Food additive E331 should be stored under such conditions that Food additive E331 is protected from moisture.
Although Food additive E331 is a salt of an acid, Food additive E331 has an alkaline pH.

Typical Properties:
Dihydrate
White
Granular crystals or crystalline powder
Typical, practically odourless
Pleasantly salty
Freely soluble in water
Practically insoluble in ethanol (96 %)
Non-toxic
Low reactive
Chemically and microbiologically stable
Fully biodegradable

Action Mechanism of Food additive E331:
Food additive E331 chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X.
This inhibits the extrinsic initiation of the coagulation cascade.

Food additive E331 may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate.
Food additive E331 is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH.

Food additive E331 Food additive E331 further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine.
Food additive E331 also acts as a diuretic and increases the urinary excretion of calcium.

Pharmacology and Biochemistry of Food additive E331:

MeSH Pharmacological Classification:

Buffers:
A chemical system that functions to control the levels of specific ions in solution.
When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

Food Preservatives:
Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.

Anticoagulants:
Agents that prevent BLOOD CLOTTING.

Manufacturing Method of Food additive E331:
Prepare the Food additive E331 buffer by mixing the Food additive E331, hydrochloric acid, and ultrapure water together in a 2L beaker or conical flask.
Use a magnetic stirrer to ensure that all reagents are properly dissolved.

Adjust to pH 6.01 with the 0.5% (w/v) sodium hydroxide and 0.5% (v/v) hydrochloric acid solutions.
Add this solution to the pressure cooker.

Place the pressure cooker on the hotplate and turn Food additive E331 on to full power.
Do not secure the lid of the pressure cooker at this point; simply rest Food additive E331 on top.

While waiting for the pressure cooker to come to the boil, dewax and rehydrate the paraffin sections by placing them in three changes of xylene for 3 min each, followed by three changes of IMS or methanol for 3 min each, followed by cold running tap water.
Keep them in the tap water until the pressure cooker comes to the boil.

Once the pressure cooker is boiling, transfer the slides from the tap water to the pressure cooker.
Take care with the hot solution and steam—use forceps and gloves. Secure the pressure cooker lid following the manufacturer’s instructions.

Once the cooker has reached full pressure (see manufacturer’s instructions), time for 3 min.

When 3 min has elapsed, turn off the hotplate and place the pressure cooker in an empty sink.
Activate the pressure release valve (see the manufacturer’s instructions) and run cold water over the cooker.

Once depressurized, open the lid and run cold water into the cooker for 10 min.
Take care with the hot solution and steam.

Continue with an appropriate immunochemical staining protocol.

Handling and storage of Food additive E331:
Handling Ensure adequate ventilation.
Avoid contact with skin, eyes or clothing.

Avoid ingestionandinhalation.
Avoid dust formation.
Storage Keep containers tightly closed in a dry, cool and well-ventilated place.

Stability and reactivity of Food additive E331:

Reactive:
Hazard None known, based on information available.

Stability:
Stable under normal conditions.
Conditions to Avoid Incompatible products.

Excess heat.
Avoid dust formation.

Incompatible Materials:
Strong oxidizing agents, Strong reducing agents, Acids, Bases

Hazardous Decomposition Products:
Carbon monoxide (CO), Carbon dioxide (CO2), Sodium oxides

Hazardous Polymerization:
Hazardous polymerization does not occur. Hazardous Reactions None under normal processing.

First-aid measures of Food additive E331:

Eye Contact:
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Get medical attention if symptoms occur.

Skin Contact:
Wash off immediately with plenty of water for at least 15 minutes.
If skin irritation persists, call a physician.

Inhalation:
Remove to fresh air.
Get medical attention immediately if symptoms occur.
If not breathing, give artificial respiration.

Ingestion:
Do NOT induce vomiting.
Get medical attention immediately if symptoms occur.

Most important symptoms and effects:
No information available.

Notes to Physician:
Treat symptomatically

Fire-fighting measures of Food additive E331:

Suitable Extinguishing Media:
Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam.

Autoignition Temperature:
500 °C / 932 °F

Accidental release measures of Food additive E331:
Personal Precautions Ensure adequate ventilation.
Avoid dust formation.

Avoid contact with skin andeyes.
Usepersonal protective equipment as required.
Environmental Precautions No special environmental precautions required.

Methods for Containment and Clean Up:
Sweep up and shovel into suitable containers for disposal.
Avoid dust formation.

Identifiers of Food additive E331:
CAS Number:
68-04-2
6132-04-3 (dihydrate)
6858-44-2 (pentahydrate)

ChEMBL: ChEMBL1355
ChemSpider: 5989
ECHA InfoCard: 100.000.614
E number: E331iii (antioxidants, ...)
PubChem CID: 6224
RTECS number: GE8300000

UNII:
RS7A450LGA
B22547B95K (dihydrate)

CompTox Dashboard (EPA): DTXSID2026363
InChI: InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
Key: HRXKRNGNAMMEHJ-UHFFFAOYSA-K
InChI=1/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
Key: HRXKRNGNAMMEHJ-DFZHHIFOAL
SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]

CAS number: 6132-04-3
EC number: 200-675-3
Grade: Ph Eur,BP,JP,USP,E 331
Hill Formula: C₆H₅Na₃O₇ * 2 H₂O
Molar Mass: 294.10 g/mol
HS Code: 2918 15 00

Product Code: NA2043
CAS Number: 6132-04-3
Assay (purity): USP
Purity method: by titration
Molecular weight: 294.10
Form: solid
Appearance: white powder
Melting point: 300C
Boiling point: 309.6C
Titration: 99.0-101.0%
Titration type: with HCLO4
Molecular formula: Na3C6H5O7 · 2H2O
Linear formula: HOC(COONa)(CH2COONa)2 · 2H2O

Properties of Food additive E331:
Chemical formula: Na3C6H5O7
Molar mass: 258.06 g/mol (anhydrous), 294.10 g/mol (dihydrate)
Appearance: White crystalline powder
Density: 1.7 g/cm3
Melting point: > 300 °C (572 °F; 573 K) (hydrates lose water ca. 150 °C)
Boiling point: Decomposes
Solubility in water: Pentahydrate form: 92 g/100 g H2O (25 °C)

Melting Point: 300°C (anhydrous substance)
pH value: 7.5 - 9.0 (50 g/l, H₂O, 25°C)
Bulk density: 600 kg/m3
Solubility: 720 g/l

Molecular Weight: 294.10 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 9
Rotatable Bond Count: 2
Exact Mass: 293.99396471 g/mol
Monoisotopic Mass: 293.99396471 g/mol
Topological Polar Surface Area: 143Ų
Heavy Atom Count: 18
Complexity: 211
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 6
Compound Is Canonicalized: Yes

Specifications of Food additive E331:
Assay (Perchloric acid titration, calc. on anhydrous substance (Ph Eur)): 99.0 - 101.0 %
Assay (Perchloric acid titration, previously dried substance) (JP/USP): 99.0 - 100.5 %
Identity (Na): passes test
Identity (Citrate): passes test
Identity (reaction upon ignition): passes test
Appearance: white to almost white crystals
Appearance of solution (100 g/l, CO₂-free water): clear and colorless
Acidity or alkalinity: passes test
pH (50 g/l CO₂-free water): 7.5 - 8.5
Chloride (Cl): ≤ 50 ppm
Sulfate (SO₄): ≤ 150 ppm
Heavy metals (as Pb): ≤ 5 ppm
Al (Aluminium): ≤ 5 ppm
As (Arsenic): ≤ 1 ppm
Hg (Mercury): ≤ 1 ppm
Pb (Lead): ≤ 1 ppm
Oxalate (as C₂H₂O₄): ≤ 100 ppm
Tartrate (C₄H₄O₆): passes test
Residual solvents (ICH (Q3C)): excluded by manufacturing process
Readily carbonisable substance: passes test
Water (according to Karl Fischer): 11.0 - 13.0 %
Loss on drying (180 °C, 18 h): 10.0 - 13.0 %

Related compounds of Food additive E331:
Monosodium citrate
Disodium citrate
Calcium citrate
Citric acid

Names of Food additive E331:

IUPAC names:
1,2,3-propanetricarboylic acid, 2-hydroxy- trisodium salt, dihydrate
2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium sal
2-Hydroxy-1,2,3-propanetrioïc acid, trisodium salt
Ascorbato di sodio trisodico anidro E331
Citric acid trisodium salt, Sodium citrate tribasic, Sodium citrate
sodium 2-hydroxypropane-1,2,3-tricarboxylate
SODIUM CITRATE
Sodium citrate
sodium citrate
Sodium citrate
sodium citrate dihydrate
Sodium Citrate dihydrate
Sodium Citrate- OR 10
Tri sodium citrate
Tri Sodium Citrate
Trinatiumcitrat dihydrat
Trinatrium-2-hydroxypropan-1,2,3-tricarboxylat
Trisodium 2-hydroxypropane-1,2,3-
Trisodium 2-hydroxypropane-1,2,3- tricarboxylate
Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
trisodium 2-hydroxypropane-1,2,3-tricarboxylate
trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate
Trisodium 2-hydroxypropane-1,2,3-tricarboxylateTrisodium citrate
Trisodium 3-hydroxy-3- carboxylate-1,5-pentanedicaroxylate
TRISODIUM CITRATE
Trisodium Citrate
Trisodium citrate
trisodium citrate
Trisodium Citrate
Trisodium citrate
trisodium citrate
trisodium citrate (dihydrate)
trisodium citrate 2-hidrate
Trisodium Citrate Dihydrate
trisodium citrate dihydrate
Trisodium citrate, Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Trisodium citrate; Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
trisodium2-hydroxypropane-1,2,3-tricarboxylate
trisodium;2-hydroxypropane-1,2,3-tricarboxylate
trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate

Preferred IUPAC name:
Trisodium 2-hydroxypropane-1,2,3-tricarboxylate

Regulatory process names:
Sodium citrate anhydrous
Trisodium citrate
trisodium citrate

Trade names:
Citrate de trisodium, dihydrate
Citrato de trisodio, dihidrato
Sodio citrato
SODIUM CITRATE
Sodium Citrate
SODIUM CITRATE DIHYDRATE
Tri-Sodium Citrate Dihydrate
Trinatriumcitraatdihydraat
Trinatriumcitrat-Dihydrat
Trisodio citrato diidrato
Trisodium citrate
trisodium citrate
TRISODIUM CITRATE DIHYDRATE
Trisodium citrate dihydrate
TRISODIUM CITRATR

Other names:
Sodium citrate
Trisodium citrate
Citrosodine
Citric acid, trisodium salt
E331

Other identifiers:
1000844-65-4
1648840-06-5
183748-56-3
2095548-08-4
6132-04-3
68-04-2
8055-55-8
856354-90-0

Synonyms of Food additive E331:
Trisodium citrate dihydrate
Sodium citrate dihydrate
6132-04-3
Sodium citrate tribasic dihydrate
Sodium citrate hydrate
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate
Citric acid trisodium salt dihydrate
Sodium citrate hydrous
SODIUM CITRATE, DIHYDRATE
trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate
MFCD00150031
B22547B95K
trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate
DTXSID1049437
Natrum citricum
Citric acid, trisodium salt, dihydrate
Citronensaeure,Trinatrium-Salz-Dihydrat
N-1560
Natrii citras, dehydrate
SODIUM CITRATE HYDROUS (II)
SODIUM CITRATE HYDROUS [II]
trisodium 2-hydroxypropane-1,2,3-tricarboxylate--water (1/2)
Trisodium citrate dihydrate;Citric acid trisodium salt dihydrate
2-hydroxy-1,2,3-propanetricarboxylic acid trisodium salt dihydrate
MFCD00130806
SODIUM CITRATE (EP MONOGRAPH)
SODIUM CITRATE [EP MONOGRAPH]
tri-sodium citrate dihydrate
TRISODIUM CITRATE DIHYDRATE (II)
TRISODIUM CITRATE DIHYDRATE [II]
UNII-B22547B95K
TRISODIUM CITRATE DIHYDRATE (USP MONOGRAPH)
TRISODIUM CITRATE DIHYDRATE [USP MONOGRAPH]
sodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate
Sodiumcitrate
Tricitrasol
Tricitrasol (TN)
Sodium citrate; Trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate; Sodium Citrate Dihydrate
Sodium citrate (TN)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, hydrate (1:3:2)
D05KTE
Sodium citrate [USP:JAN]
Sodiumcitratetribasicdihydrate
SODIUM CITRATE [FHFI]
DTXCID0029397
Sodium citrate hydrate (JP17)
CHEBI:32142
Trisodium citrate dihydrate, ACS
NLJMYIDDQXHKNR-UHFFFAOYSA-K
SODIUM CITRATE HYDRATE [JAN]
SODIUM CITRATE DIHYDRATE [MI]
AKOS025293920
Sodium citrate dihydrate, >=99%, FG
SODIUM CITRATE DIHYDRATE [VANDF]
BP-31019
SODIUM CITRATE DIHYDRATE [WHO-DD]
Sodium citrate tribasic dihydrate, >=98%
Sodium citrate dihydrate, ACS reagent grade
SODIUM CITRATE, DIHYDRATE [WHO-IP]
D01781
F82065
Sodium citrate tribasic dihydrate, AR, >=99%
Sodium citrate tribasic dihydrate, LR, >=99%
Citric acid trisodium salt dihydrate ACS reagent
NATRII CITRAS, DEHYDRATE [WHO-IP LATIN]
A833161
A835986
Q22075862
Sodium citrate dihydrate Biochemical grade, Fine Granular
Sodium citrate tribasic dihydrate, USP, 99.0-100.5%
Sodium Citrate Tribasic Dihydrate (Molecular Biology Grade)
Sodium citrate tribasic dihydrate, ACS reagent, >=99.0%
trisodium 2-oxidanylpropane-1,2,3-tricarboxylate dihydrate
Citric acid trisodium salt dihydrateTrisodium citrate dihydrate
Sodium citrate tribasic dihydrate, BioUltra, >=99.0% (NT)
Sodium citrate tribasic dihydrate, insect cell culture tested
Sodium citrate tribasic dihydrate, JIS special grade, >=99.0%
Sodium citrate tribasic dihydrate, p.a., ACS reagent, 99.0%
Sodium citrate tribasic dihydrate, purum p.a., >=99.0% (NT)
Sodium citrate tribasic dihydrate, SAJ first grade, >=99.0%
Sodium citrate tribasic dihydrate, tested according to Ph.Eur.
Trisodium citrate dihydrate, meets USP testing specifications
Sodium citrate tribasic dihydrate, BioXtra, >=99.0% (titration)
Sodium citrate tribasic dihydrate, for molecular biology, >=99%
Sodium citrate tribasic dihydrate, Vetec(TM) reagent grade, 98%
Sodium citrate, United States Pharmacopeia (USP) Reference Standard
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, dihydrate
2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium salt, dihydrate
Sodium citrate tribasic dihydrate, p.a., ACS reagent, reag. ISO, 99-101%
Sodium citrate tribasic dihydrate, BioUltra, for molecular biology, >=99.5% (NT)
Sodium citrate tribasic dihydrate, puriss. p.a., ACS reagent, >=99.0% (NT)
Sodium citrate tribasic dihydrate, suitable for amino acid analysis, >=99.0%
Sodium Citrate, Pharmaceutical Secondary Standard; Certified Reference Material
Sodium citrate tribasic dihydrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5%
Sodium citrate tribasic dihydrate, suitable for amino acid analysis, >=98% (titration), powder
Trisodium citrate [ACD/IUPAC Name] [Wiki]
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3) [ACD/Index Name]
200-675-3 [EINECS]
68-04-2 [RN]
994-36-5 [RN]
Citrate de trisodium [French] [ACD/IUPAC Name]
Citric Acid Trisodium Salt
MFCD00012462 [MDL number]
RS7A450LGA
Sodium 2-hydroxy-1,2,3-propanetricarboxylate
Sodium Citrate [JAN] [USAN] [Wiki]
Sodium citrate anhydrous
Trinatriumcitrat [German] [ACD/IUPAC Name]
Tris sodium citrate
trisodium 2-hydroxypropane-1,2,3-tricarboxylate
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt
114456-61-0 [RN]
205-623-3 [EINECS]
2-Hydroxy-1,2,3-propanenetricarboxylic acid trisodium salt
2-Hydroxy-1,2,3-propanetricarboxylic acid trisodium salt
2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium salt
Citnatin
Citrate Concentratedmissing
citrate sodium
citrate trisodium
Citratemissing
Citreme
Citric acid sodium salt anhydrous
Citric acid trisodium salt, anhydrous
Citric acid, trisodium salt
Citrosodina
Citrosodine
Citrosodna
Isolyte E
Natrocitral
Sodium 2-hydroxypropane-1,2,3-tricarboxylate
Sodium citrate (USP)
Sodium citrate buffer
SODIUM CITRATE TRIBASIC
Sodium citrate, anhydrous
Synthesis on demand
tri-sodium citrate
Trisodium citrate anhydrous
tris-sodium citrate
UNII-RS7A450LGA
FOOD GRADE CMC

Food grade carboxymethyl cellulose (CMC) is a food additive derived from cellulose, a naturally occurring polymer found in the cell walls of plants.
Food grade CMC is commonly used in the food industry as a thickener, stabilizer, and emulsifier.

CAS Number: 9004-32-4
EC Number: 232-674-9

Synonyms: Carboxymethyl cellulose, CMC, Sodium carboxymethyl cellulose, Sodium CMC, Carboxymethylcellulose sodium, Carboxymethyl cellulose sodium salt, Cellulose gum, Cellulose, carboxymethyl ether, Sodium cellulose glycolate, Sodium carboxymethyl ether, Carboxymethyl ether of cellulose, Carmellose sodium, Carmellose, E466, E466 (additive), CMC sodium, Sodium carmellose, Cellulose methyl ether, Sodium salt of carboxymethylcellulose, Carboxymethylcellulose sodium salt, Carmalose sodium, Sodium CMC gum, Aqualon CMC, CMC-Na, CMC, Na, Sodium carboxymethylcellulose gum, Sodium cellulose glycolate, Cellulose, 2-(carboxymethoxy)-, sodium salt, Carbose, Methocel, Tylose, Tylose C, Akucell, Aquaplast, Clarcel, Cellogen, Nymcel, Cekol, Aqualon, Akucell AF 3265, CLD CMC, Cellofas, Finnfix, Nymcel ZSB 10, Cellulose, 2-(carboxymethoxy)-, sodium salt, Blanose, Proflo, Supercol, Terlite, Mellojel, Lamitex, Kolaton, Expandex, Agrimerica CMC, Ac-Di-Sol, Kolvisol



APPLICATIONS


Food grade carboxymethyl cellulose (CMC) is widely used as a thickener in various food products.
Food grade CMC is commonly added to sauces, gravies, and soups to improve their viscosity and texture.
Food grade CMC acts as a stabilizer in salad dressings, preventing separation of oil and vinegar.

In dairy products such as yogurt and ice cream, CMC enhances texture and prevents syneresis.
Food grade CMC is used in baked goods like bread and cakes to improve dough consistency and increase volume.
Food grade CMC is added to fruit fillings and pie fillings to provide a smooth, uniform texture.

Food grade CMC acts as a moisture retention agent in meat products, improving juiciness and tenderness.
In beverages, CMC is used to suspend insoluble ingredients and enhance mouthfeel.

Food grade CMC is added to low-fat and reduced-calorie foods as a fat replacer, providing texture without added calories.
Food grade CMC is used in gluten-free baking to improve the structure and texture of baked goods.
Food grade CMC is employed in confectionery products such as gummies and candies to prevent sugar crystallization.

In frozen desserts like ice cream and sorbet, CMC improves texture and prevents ice crystal formation.
Food grade CMC is used in fruit preserves and jams to improve spreadability and prevent syneresis.

Food grade CMC is added to instant noodles and pasta to improve texture and prevent sticking.
Food grade CMC acts as a binder in extruded snacks and cereals, improving shape and crunchiness.

Food grade CMC is used in pet foods to improve palatability and texture.
In sauces and marinades, CMC improves cling and coating properties.
Food grade CMC is employed in dietary supplements as a capsule coating and disintegrant.

Food grade CMC is added to canned fruits and vegetables to maintain texture and prevent mushiness.
Food grade CMC is used in whipped toppings and dessert mixes to improve stability and texture.

In toothpaste formulations, CMC serves as a thickener and binder for active ingredients.
Food grade CMC is added to pharmaceutical suspensions and solutions as a stabilizer and viscosity enhancer.
Food grade CMC is used in cosmetics and personal care products as a thickening agent and emulsifier.

Food grade CMC is employed in paper and textile industries for its binding and sizing properties.
Applications of food grade carboxymethyl cellulose (CMC) span a wide range of food, pharmaceutical, cosmetic, and industrial products, contributing to their stability, texture, and performance.

Food grade CMC is used in fruit juices and smoothies to enhance mouthfeel and prevent settling of pulp.
Food grade CMC is added to instant pudding mixes to improve texture and creaminess.

Food grade CMC is employed in canned soup and broth to improve viscosity and suspension of ingredients.
In frozen pizzas and prepared meals, CMC helps maintain the integrity of toppings and sauces during freezing and reheating.
Food grade CMC is used in salad kits and pre-packaged salads to prevent wilting of leafy greens.

Food grade CMC is added to nutritional bars and meal replacement shakes as a binding agent.
In fruit-flavored snacks and fruit leathers, CMC improves texture and prevents sticking.

Food grade CMC is used in baby foods and infant formulas to improve texture and consistency.
Food grade CMC is employed in instant coffee and tea mixes to improve solubility and prevent clumping.

In instant mashed potatoes and potato products, CMC improves texture and mouthfeel.
Food grade CMC is added to vegetable oil sprays to improve sprayability and prevent clogging.
Food grade CMC is used in whipped cream products to improve stability and prevent collapse.
Food grade CMC is employed in gluten-free baking mixes to improve texture and rise.

In meal replacement shakes and protein powders, CMC improves suspension of ingredients.
Food grade CMC is added to sports drinks and electrolyte beverages to improve mouthfeel and stability.

Food grade CMC is used in canned pet foods to improve texture and palatability.
Food grade CMC is employed in cake mixes and frosting to improve stability and texture.

In dietary supplements such as fiber supplements, CMC improves dispersibility and palatability.
Food grade CMC is added to nut butter spreads to prevent oil separation and improve spreadability.

Food grade CMC is used in fruit-based spreads and jellies to improve gel formation and texture.
Food grade CMC is employed in whipped butter and margarine to improve texture and spreadability.
In instant oatmeal and cereal mixes, CMC improves texture and thickness.

Food grade CMC is added to frozen fruit bars and popsicles to improve texture and prevent iciness.
Food grade CMC is employed in salad toppings and croutons to improve adhesion and prevent sogginess.

Overall, the versatility of food grade carboxymethyl cellulose (CMC) allows it to be utilized in a diverse array of food and beverage products, enhancing quality, stability, and consumer satisfaction.

Food grade CMC is non-toxic and safe for consumption when used in accordance with regulatory guidelines.
Food grade CMC undergoes rigorous quality control measures to ensure purity and consistency.

Food grade CMC is biodegradable under aerobic conditions, aligning with sustainability goals.
Food grade CMC plays a crucial role in enhancing the quality, stability, and sensory attributes of a wide range of food products.
Food grade CMC is an indispensable ingredient in the food industry, contributing to the development of innovative and high-quality food products.



DESCRIPTION


Food grade carboxymethyl cellulose (CMC) is a food additive derived from cellulose, a naturally occurring polymer found in the cell walls of plants.
Food grade CMC is commonly used in the food industry as a thickener, stabilizer, and emulsifier.
Food grade CMCundergoes a chemical modification process where carboxymethyl groups (-CH2COONa) are introduced onto the cellulose backbone, resulting in a water-soluble polymer with desirable properties for food applications.

Food grade carboxymethyl cellulose (CMC) is a versatile food additive widely used in the food industry.
Food grade CMC is derived from cellulose, a natural polymer found in the cell walls of plants.
Food grade CMC is commonly used as a thickener, stabilizer, and emulsifier in a variety of food products.

This white to off-white powder has a neutral odor and taste, making it suitable for use in foods.
Food grade CMC is highly soluble in water, forming clear to slightly opalescent solutions.

Food grade CMC imparts viscosity and texture to food products, enhancing their appearance and mouthfeel.
As a stabilizer, it helps to prevent ingredient separation in liquid formulations such as sauces and dressings.

Food grade CMC acts as a suspending agent, preventing settling of solid particles in beverages and sauces.
Food grade CMC can also form gels in certain food applications, providing structure and stability.
CMC is often used in low-fat and reduced-calorie foods as a fat replacer, contributing to their texture and mouthfeel.
In baking, it improves dough consistency and enhances the volume and texture of baked goods.

Food grade CMC is compatible with a wide range of other food ingredients and additives.
Food grade CMC is pH-stable, maintaining its functionality over a wide range of pH levels.

Food grade CMC is heat-stable, making it suitable for use in both hot and cold food applications.
Food grade CMC has excellent freeze-thaw stability, maintaining its properties after freezing and thawing.

Food grade CMC can form edible films and coatings on food surfaces, extending shelf life and improving appearance.
Food grade CMC contributes to the stability and consistency of dairy products such as yogurt and ice cream.
Food grade CMC helps to control crystal formation in frozen desserts, preventing the formation of ice crystals.

Food grade CMC is often used in confectionery products to improve texture and prevent sugar crystallization.
In meat products, it enhances moisture retention and improves binding properties.



PROPERTIES


Physical Properties:
Appearance: White to off-white powder or granules.
Odor: Odorless.
Taste: Tasteless.
Solubility: Highly soluble in water, forming clear to slightly opalescent solutions. Insoluble in organic solvents.
Density: Typically around 0.5-0.7 g/cm³ for the powder form.
Viscosity: Varies depending on the molecular weight, degree of substitution, and concentration; can range from low to high viscosity grades.
pH: Usually between 6.5 and 8.5 for a 1% aqueous solution.
Particle Size: Fine powder with particle size typically around 80-100 mesh.
Moisture Content: Generally less than 10% for most commercial grades.
Hygroscopicity: Hygroscopic, absorbs moisture from the air.
Ash Content: Typically less than 1%.


Chemical Properties:

CAS Number: Varies depending on the specific grade and manufacturer.
EC Number: Varies depending on the specific grade and manufacturer.
Degree of Substitution (DS): Typically between 0.6 and 1.2 (indicates the average number of carboxymethyl groups per glucose unit).
Functional Groups: Hydroxyl (-OH), carboxymethyl (-CH2COONa), and ether (R-O-R).
Thermal Stability: Decomposes upon heating above 200°C.
pKa: Around 4.3 for the carboxyl groups.
Reactivity: Reacts with acids to form free carboxymethyl cellulose; reacts with metal ions to form insoluble salts.
Ionic Nature: Anionic due to the presence of carboxylate groups.
Compatibility: Compatible with a wide range of other water-soluble polymers and surfactants.
Biodegradability: Biodegradable under aerobic conditions.



FIRST AID


1. Inhalation:

Immediate Actions:
If inhaled, remove the affected person to fresh air immediately.

Assessment:
Check the individual's breathing. If breathing is difficult, ensure a clear airway and administer oxygen if available.

Medical Attention:
Seek medical assistance if respiratory symptoms persist or worsen.


2. Skin Contact:

Immediate Actions:
Remove contaminated clothing and rinse the affected area with plenty of water.

Washing:
Wash the skin thoroughly with soap and water for at least 15 minutes.

Medical Attention:
Seek medical advice if irritation persists or if skin damage is evident.


3. Eye Contact:

Immediate Actions:
Flush the eyes with lukewarm water for at least 15 minutes, lifting the eyelids occasionally to ensure thorough rinsing.

Contact Lenses:
Remove contact lenses if present and continue rinsing.

Medical Attention:
Seek immediate medical attention if irritation, pain, or visual disturbances occur.


4. Ingestion:

Immediate Actions:
Do not induce vomiting. Rinse the mouth thoroughly with water.

Medical Attention:
Seek medical advice immediately. Provide medical personnel with information about the ingested substance.


Additional First Aid Information

Personal Protection:
Ensure the safety of first responders by providing appropriate personal protective equipment (PPE).

Documentation:
Record details of the exposure, including the route of exposure, symptoms observed, and actions taken.

Monitoring:
Monitor the affected individual for signs of respiratory distress, skin irritation, or other symptoms.

Transportation:
If medical attention is required, transport the individual to a medical facility as soon as possible.

Follow-Up:
Provide follow-up care as necessary and monitor for delayed or secondary effects of exposure.


Preventive Measures

Workplace Safety:
Implement measures to minimize the risk of exposure, such as proper ventilation and handling procedures.

Training:
Provide training to employees on the safe handling and use of food grade carboxymethyl cellulose (CMC).

Storage:
Store food grade CMC in a cool, dry place away from incompatible materials and sources of ignition.

Emergency Response:
Have an emergency response plan in place, including procedures for spills and exposures.



HANDLING AND STORAGE


Handling

1. Personal Protective Equipment (PPE)

Respiratory Protection:
Use appropriate respiratory protection (e.g., dust mask) if handling food grade carboxymethyl cellulose (CMC) in dusty environments or where airborne exposure is possible.

Skin Protection:
Wear protective gloves, clothing, and footwear to prevent skin contact.

Eye Protection:
Wear safety goggles or face shield to protect eyes from potential splashes or dust.


2. Handling Practices

Minimize Dust:
Avoid generating dust by handling food grade carboxymethyl cellulose (CMC) carefully and using dust control measures such as local exhaust ventilation or wet methods.

Avoid Direct Contact:
Minimize direct skin contact with food grade CMC. Wash hands thoroughly after handling.

Do Not Eat, Drink, or Smoke:
Avoid eating, drinking, or smoking while handling food grade carboxymethyl cellulose (CMC) to prevent accidental ingestion.

Work Area Hygiene:
Maintain good housekeeping practices in work areas to prevent the accumulation of dust and spills.


3. Equipment and Tools

Use Suitable Equipment:
Use appropriate handling equipment (e.g., scoops, shovels) to transfer food grade carboxymethyl cellulose (CMC) to minimize dust generation.

Cleaning Equipment:
Clean handling equipment regularly to prevent cross-contamination.

Labeling:
Clearly label containers of food grade CMC with product information and handling precautions.


Storage

1. Storage Conditions

Temperature:
Store food grade carboxymethyl cellulose (CMC) in a cool, dry, well-ventilated area away from heat sources and direct sunlight.

Humidity Control:
Maintain humidity levels to prevent moisture absorption, which can affect the quality and flow properties of food grade CMC.

Avoid Contamination:
Store food grade carboxymethyl cellulose (CMC) away from incompatible materials, such as acids, oxidizing agents, and strong bases.

Segregation:
Separate food grade CMC from food, feed, and other materials to prevent contamination.


2. Container Handling

Original Packaging:
Store food grade carboxymethyl cellulose (CMC) in its original packaging or in suitable containers that are tightly sealed to prevent moisture ingress.

Avoid Damage:
Handle containers carefully to prevent damage that could lead to spills or contamination.

Check Integrity:
Regularly inspect containers for signs of damage or leaks. Dispose of damaged containers appropriately.


3. Special Considerations

Bulk Storage:
If storing food grade carboxymethyl cellulose (CMC) in bulk quantities, use appropriate storage facilities equipped with dust control measures and fire protection systems.

Temperature Control:
Monitor storage temperatures to prevent exposure to extreme heat or cold, which could affect product stability.

Emergency Response:
Have spill response procedures and cleanup materials readily available in case of accidental spills or releases.

FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.


CAS Number: 7758-16-9
EC Number: 231-835-0
Chemical Formula: Na2H2P2O7



SYNONYMS:
Diphosphoric acid, disodium salt, Disodium dihydrogen pyrophosphate, Disodium diphosphate, Sodium acid pyrophosphate, SAPP, disodium dihydrogen pyrophosphate, disodium pyrophosphate, SAPP, SAPP Powder FCC PODR K SAPP-28, Sodium Acid Pyrophosphate FCC Powder Kosher [SAPP 28], SAPP, Hi-B283, Disodium dihydrogen diphosphate, Diphosphoric acid, disodium salt, Disodium dihydrogen pyrophosphate, Disodium diphosphate, Sodium acid pyrophosphate, SAPP,
Diphosphoric Acid Disodium Salt, Disodium Dihydrogen Pyrophosphate, SAPP, Disodium pyrophosphate, Disodium dihydrogen diphosphate, Disodium Diphosphate, Disodium Pyrophosphate, SAPP, Disodium Pyrophosphate, Disodium Diphosphate, Disodium Dihydrogen Diphosphate, Disodium Dihydrogen Pyrophosphate, Diphosphoric Acid, Disodium Salt, Pyrophosphoric Acid, Disodium Salt, Disodium pyrophosphate, Disodium diphosphate, Disodium dihydrogen pyrophosphate, Acid sodium pyrophosphate Disodium, Disodium Pyrophosphate, Disodium Diphosphate, Disodium Dihydrogen Diphosphate, Disodium Dihydrogen Pyrophosphate, Diphosphoric Acid, Disodium Salt, Pyrophosphoric Acid, Disodium Salt, Diphosphoric Acid Disodium Salt, Disodium Dihydrogen Pyrophosphate, Disodium Pyrophosphate, E 450, SAPP, SAPP Food Grade, SAPP, DisodiuM pytophospha, Disodium Pyrophosphate, Disodium pytophosphate, Sodium Acid Pyrophosphate, Dentin sialophosphoprotein, Sodium pyrophosphate dibasic, disodium phosphonato phosphate, Diphosphoric acid, disodium salt, disodium dihydrogenpyrophosphate, Disodium Dihydrogen Pyrophosphate, TwosodiuM pyrophosphatetwo hydrogen, SODIUM PYROPHOSPHATE DIBASIC BIOULTR, Food Grade Sodium Acid Pyrophosphate, Amyloid Precursor Protein β, Secreted, di-sodium dihydrogen pyrophosphate anhydrous, SodiuM pyrophosphate dibasic practical grade



Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound with the chemical formula Na2H2P2O7.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 consists of sodium cations (Na+) and dihydrogen pyrophosphate anions (H2P2O2−7).
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.


When crystallized from water, Food Grade Sodium Acid Pyrophosphate / SAPP 28 forms a hexahydrate, but it dehydrates above room temperature.
Pyrophosphate is a polyvalent anion with a high affinity for polyvalent cations, e.g. Ca2+.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is produced by heating sodium dihydrogen phosphate:
2 NaH2PO4 → Na2H2P2O7 + H2O


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is extensively used in food processing, as in canned seafood, cured meat, bakery and potato products, to adjust the pH, maintain color, improve flavour and improve the water-holding capacity.


The leavening acid, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an important component of double acting baking powder, as well as self rising flour.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 reacts in stages and is desirable in baking applications for its slow action.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound that is often used as a leavening agent in the baking industry.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is white powder or granular in appearance.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is soluble in water.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.


When crystallized from water, Food Grade Sodium Acid Pyrophosphate / SAPP 28 forms a hexahydrate, but it dehydrates above room temperature.
Pyrophosphate is a polyvalent anion with a high affinity for polyvalent cations, e.g., Ca2+.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a popular leavening agent found in baking powders.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 combines with sodium bicarbonate to release carbon dioxide.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a food-grade chemical often used in the culinary industry as a leavening agent, as well as an emulsifier, a buffering agent, and a texturizer.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is one of the two acid components used in commercial baking powder.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white powder commonly used in food processing to adjust the pH, maintain color, improve the water-holding capacity and reduce purge during retorting.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white granular powder that is used as a rapid fermenting agent.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be applied to acid component of synthetic swelling agent, such as bread and cake.
Blended with other phosphates Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be applied to water retention of meat product, such as canned meat, cooked ham, and instant noodles.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is white monoclinic crystal fine powder, active melt, hygroscopic, soluble in water, and insoluble in ethanol.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a food moisture retention agent allowed by my country's regulations.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is anhydrous white powder, free flowing, odorless, tasteless and food-grade.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 meets the specifications of the current Code of Chemicals Food for sodium acid pyrophosphate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 may be used In non-dairy creams, SAPP NL-170, is added to protect the proteins from heat dehydration, to stabilize the fat emulsion, and to stabilize the product along with many other formulations.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is designated in the USA as generally recognized as safe for food use.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an acid source for reaction with baking soda to leaven baked goods.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble that serves as a buffering and chelating agent, with many applications in the food industry.


When crystallised from water, Food Grade Sodium Acid Pyrophosphate / SAPP 28 forms hexahydrate, but it dehydrates above room temperature.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a polyvalent anion with a high affinity for polyvalent cations.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a popular leavening agent found in baking powders.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 combines with sodium bicarbonate to release carbon dioxide.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is available in a variety of grades that effect the speed of its action.
Store Food Grade Sodium Acid Pyrophosphate / SAPP 28 in a cool, dry place.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white crystalline powder
Food Grade Sodium Acid Pyrophosphate / SAPP 28 also known as Di-sodium Di-phosphate is an inorganic compound of sodium and pyrophosphate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is white and soluble in water.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is manufactured with double drying process like other Pyrophosphates due to heating needed at a high temperature.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Sodium Acid Pyrophosphate.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is White powder, soluble in water, acidic property appeared in aqueous solution.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can leave a slightly bitter aftertaste in some products, but "the SAPP taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white powder soluble in water giving acidic solutions.
Food Grade Sodium Acid Pyrophosphate is available in two grades; medium acting leavening powder (SAPP 28) and fast acting leavening powder (SAPP 40).
The two grades offer a selection based on their rate of reaction with bicarbonate during the mixing of doughs or batters.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound consisting of sodium cations and pyrophosphate anions.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a food additive whose role is to improve the quality and stability of food products.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white powder or granular.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is one of the most popular chemicals, especially as a food additive.
Food Grade Sodium Acid Pyrophosphate / SAPP 28, also known as disodium pyrophosphate, is a white, water-soluble solid with the chemical formula Na2H2P2O7, which has many applications in the food industry.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is produced by partial neutralization of food phosphoric acid with sodium hydroxide or sodium carbonate to form monosodium phosphate, which is then dehydrated at 250°C to form sodium pyrophosphate acid.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 readily dissolves and forms the pyrophosphate anion, which then interacts with the proteins in a fully cooked mixture to create a moist texture.


Also, Food Grade Sodium Acid Pyrophosphate / SAPP 28 acts as a buffering agent for pulp in the pH range of 7.3 to 7.5, which affects the color of the final product.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also known as disodium pyrophosphate.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Sodium Acid Pyrophosphate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 has a dough reaction rate of 24 - 28.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an all-purpose phosphate commonly used in prepared mixes, commercial baking powders, and cake doughnut mixes.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is available in white, crystalline powder or granules, that are odorless and has a slightly acidic taste.


Both Food Grade Sodium Acid Pyrophosphate / SAPP 28 and GDL have a slightly bitter aftertaste.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an emulsifying agent in cheeses and related products.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 accelerates the cooking in processed meat and poultry products.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Sodium Acid Pyrophosphate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an inorganic compound consisting of sodium cations and pyrophosphate anion.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a widely used acidic salt, which is used in a variety of baked and fried foods.
The ROR value of Food Grade Sodium Acid Pyrophosphate / SAPP 28 is the gas production rate, which refers to sodium bicarbonate and sodium acid pyrophosphate, in the environment of wet dough, the amount of carbon dioxide actually released at 8 minutes accounts for the proportion of the total carbon dioxide volume released by the theory.


The gas-producing rate of Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a range value, not a fixed value, and is commonly expressed by ROR.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a medium-speed fermentation agent and is usually a high-demand product.
Value range 24-30, fast product ROR 40 range is 35-43, slow fermentation agent ROR 15 range is 13-17, the demand is very small.


Food Grade Sodium Acid Pyrophosphate / SAPP 28, also known as disodium pyrophosphate, is an inorganic compound composed of sodium cation and pyrophosphate anion.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble solid, commonly used as a buffer and chelating agent and has many applications in food processing industry.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Sodium Acid Pyrophosphate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 has a dough reaction rate of 24 - 28.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an all-purpose phosphate commonly used in prepared mixes, commercial baking powders, and cake doughnut mixes.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is white power.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is soluble in water, but insoluble in alcohol.
solubility of Food Grade Sodium Acid Pyrophosphate / SAPP 28 is 32.5% at 100°C.
Food Grade Sodium Acid Pyrophosphate / SAPP 28, also known as disodium dihydrogen pyrophosphate, disodium pyrophosphate.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is white crystalline powder, which has the relative density of 1.864 and can decompose into sodium metaphosphate when it is heated above 220℃.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is easily soluble in water and can form chelates with Cu2+ and Fe2+.


The aqueous solution of Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be hydrolyzed to phosphoric acid by heating with dilute sulfuric acid or dilute mineral acid.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an aerator grade of sodium acid pyrophosphate for bakery applications with a slow Rate of Reaction.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 has a rate of reaction of 26 - 30% CO2 in 8 minutes.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a crystalline acid salt Na2H2P2O7 of pyrophosphoric acid that has been added to hot dogs to give them color -called also sodium acid pyrophosphate.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 prevents change in colour darkening in potatoes and sugar syrups.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is the slowest-acting sodium acid pyrophosphate.



USES and APPLICATIONS of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is usually used in food processing industry.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as baking powder, the fermentation speed can be fast or slow based on different uses.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can control fermentation speed and increase production intensity in baking products.


For instant noodles, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can reduce the rehydration time of finished products, and make it not sticky.
For biscuits and pastries, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can shorten the fermentation time, reduce products damage rate, make the loose gap neat, as well as extend the storage period.


For meat and aquatic products processing, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as quality improver.
In the food industry as a rapid starter culture, quality improver, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used for bread, pastries and other synthetic leavening agents of acid components.


With other phosphate compound, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used for lunch meat, cooked ham, canned meat and other meat products, such as water retention agents, instant noodle rehydration agents.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a starter, for baking food and controlling the fermentation speed.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in oil well drilling together with drilling mud to give a coating along the wall of the wells, by which the surface become hard and does not collapse while pipes are being inserted.
Common industrial uses include: Meat Processing, Potato-based Products, Dairy Products, Snacks, Bakery, and Seafood.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is commonly used in the food industry as a leavening agent, acidulant, or buffer.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 releases Carbon Dioxide slowly upon reaction with Sodium Bicarbonate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can also be used to maintain color in things like canned seafood or frozen potato products like hashbrowns.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used Baking Powder, Cake Mixes, Cupcakes, Doughnuts, Leavening Agent, and Refrigerated Dough.
Food additive: Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as a food additive to adjust pH, stabilize pH value, and play a role in preserving freshness and protecting food quality.


Metal surface treatment: Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as a metal surface treatment agent to remove oxides and rust, thereby improving the adhesion of the metal surface.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used Leavening agent for bakery products, pH control in processed foods, Buffering agent, Emulsifier, and Nutrient.


In the food industry, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a buffer, leavening agent, chelating agent, stabilizer, emulsifier and color improver.
Canned food: Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used buffering agent.


Ham: Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used leavening agent.
Meat: Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used sequestrant agent.
As a food-grade additive, Food Grade Sodium Acid Pyrophosphate / SAPP 28 helps control the pH levels in processed foods and is essential in the leavening of bakery products.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 reacts with baking soda to release carbon dioxide, which helps dough rise.
This property is especially valuable in products like cakes, pancakes, and biscuits.
Additionally, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as a buffer, emulsifier, and nutrient in various food applications.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used for instant noodles to reduce the rehydration time of finished products, and it is not sticky or rotten.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used for biscuits and cakes, shorten the fermentation time, reduce the product damage rate, loosen and tidy the pores, and prolong the storage period.


Canned seafood: Struvite crystal is occasionally found in canned seafood, and Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used to inhibit its formation, such as in canned tuna.
Generally, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an acid component in baking powder; as a chelating agent or combines with other polyphosphates to sequester magnesium and iron ions, e.g. chelate iron during the processing of potatoes to prevent a dark discoloration.


In the bakery, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a slow leavening acid and it may contain a suitable aluminum and/or calcium salt to control the rate of reaction.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used bakery, Canned SeaFood, and Potato Products


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used together with baking powder as a leavening agent to release carbon dioxide.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is ideal for refrigerated doughs, cakes, muffins and pancake mixes where a slow reaction rate is desired.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is often used with fast-acting leavenings such as monocalcium phosphate in double-acting baking powder or sometimes added with another slow action leavening acid, GDL.


Frozen raw dough used in biscuits and bread products uses slow acidic Food Grade Sodium Acid Pyrophosphate / SAPP 28, which requires the release of carbon dioxide at a slower starting rate during preparation and packaging, and a large release of gas during baking.
Low gas rate means that Food Grade Sodium Acid Pyrophosphate / SAPP 28 and sodium bicarbonate emit no more than 22% of the total carbon dioxide in 8 minutes.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in the food industry as a raising agent for flat baked goods, such as cookies and crackers.
Chemical analysis: Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as a buffer and reagent in chemical analysis.
As a starter, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used for baking food, controlling fermentation speed, for instant noodles, reducing rehydration time of finished products, and not sticking to it.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used for biscuits and pastry, shortening fermentation time, reducing product breakage rate, loose and neat space, and prolonging storage period.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is commonly used as a leavening agent and is an important component of baking powder as well as flour itself.


Yeasts add air and volume to the baked product structure by reacting with baking soda to produce carbon dioxide gas and also change dough characteristics by creating ionic bonds with starches and dough proteins.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as a leavening chemical to help bread rise.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in sausages to increase flavor and color.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble solid that serves as a leavening agent, buffering and chelating agent, with many applications in the food industry.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening agent in bakery products; seafood canning and in potato treatment.
As a leavening agent, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is applied to roast foodstuffs to control the fermentation speed.
When applied to instant noodles, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can shorten water resetting time and avoid stickiness and mushiness of the noodles.


When applied to crackers or cakes, Food Grade Sodium Acid Pyrophosphate / SAPP 28 may shorten fermentation time,lower the breakage, make the porous space in good order and therefore lengthen the shelf life.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in canned seafood to maintain color and reduce purge during retorting.


Retorting achieves microbial stability with heat.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening agent, reducing zymosis time and can also be used as a water retention agent, and a quality improver for meat and sea food processing.


In French fries, Food Grade Sodium Acid Pyrophosphate / SAPP 28 reduces levels of a carcinogen called acrylamide, according to an article from the Center for Science in the Public Interest.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 also prevents the discoloration of potatoes and sugar syrup and the formation of harmless struvite crystals in canned tuna.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 can also be used in leather treatment.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in some dairy applications for cleaning purposes as well as in the oil production industry.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 may be used as leavening acid which combines with baking soda to release carbon dioxide to improve the texture and volume of baked goods.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is in China in steamed buns and Chinese almond cookies.
In China Food Grade Sodium Acid Pyrophosphate / SAPP 28 is called edible or food-grade "smelly powder".
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is commonly used as an inexpensive nitrogen fertilizer in China


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is now being phased out in favor of urea for quality and stability.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in food processing, as in canned seafood, cured meat and potato products, for adjust the pH, maintain color, improve the water-holding capacity and reduce purge during retorting


Sodium pyrophosphate is used as a fast fermentation agent, quality improver, puffer, buffer, etc. in food processing, and is often used as an acidic ingredient in synthetic puffing agents such as bread and pastries.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used bread, cakes, bread and other foods are characterized by spongy porous tissue to create a soft taste.


In order to achieve this, a sufficient amount of gas must be kept in the dough.
The water vapor produced by the heating of the air and moisture in the material mixture during baking can cause the product to produce some spongy tissue, but the amount of gas is far from enough.


The vast majority of the gas required is provided by puffing agents.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is commonly used compound puffer is a carbon dioxide gas produced by the action of sodium bicarbonate and acidic salts.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as buffer, leaven, quality modifier, ferment agent, emulsifier, nutriment, adhesive and preservative in foods.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also a basic fertilizer being a source of ammonia


In food processing industry, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as buffering, swelling agent, chelating agent, stabilizers, emulsifier and color improver.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as baking powder in baking food to control the degree of fermentation and improve the production intensity.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used for instant noodles to shorten the rehydration time of the finished product, so that instant noodles won’t be sticky or rotten.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in sausages to enhance flavor and color.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in biscuits and cakes, it can shorten the fermentation time, reduce the product breakage rate, loosen the gaps neatly, and prolong the storage period.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a quality improver for bakery foods such as bread, biscuits, meat and aquatic products, etc.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 can improve the complex metal ions, PH value and ionic strength of foods, thereby improving the adhesion and water holding capacity of foods,
In French Fries, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can reduce levels of a carcinogen called acrylamide.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a chelating agent to chelate iron to prevent discoloration in processed potato.
For industry, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is applied to oil area as a drilling fluid.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in leather treatment to remove iron stains


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is widely used globally in food industry for baking reaction purpose
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also used to stabilize the solution of hydrogen peroxide against reduction
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in petroleum industry as a dispersant in oil well drilling muds


Food Grade Sodium Acid Pyrophosphate / SAPP 28 also has a wide use in dairy and poultry processes.
Because the resulting phosphate residue has an off-taste, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is usually used in very sweet cakes which mask the taste.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is designated in the USA as generally recognized as safe for food use.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in canned seafood to maintain color and reduce purge during retorting.
Retorting achieves microbial stability with heat.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an acid source for reaction with baking soda to leaven baked goods.
In baking powder, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is often labeled as food additive E450.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can also prevent discoloration of potatoes and syrup.


In canned tuna, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can prevent the formation of harmless struvite crystals.
In canned seafood, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can retain color during cooking and reduce cleaning.
In cured meats, Food Grade Sodium Acid Pyrophosphate / SAPP 28 accelerates the conversion of sodium nitrite to nitrite by forming a nitrous acid intermediate and can improve water retention.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in frozen hash browns and other potato products to prevent potatoes from darkening.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 may leave a slightly bitter aftertaste in some products, but adding calcium ions, sugar, or flavoring can mask the taste.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is mainly used in the bakery industry at a leavening agent.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 may also be blended with other phosphates and used for water retention in processed meats, and used to maintain the appearance and texture of uncooked fruits and vegetables.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white, water-soluble solid, commonly used as a buffer and chelating agent and has many applications in food processing industry.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an acidulant, buffering agent, and leavening agent.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is developed specifically for use in canned, refrigerated biscuit doughs.
The CO2 release is extremely low - enabling doughs to be held for long periods, even at above normal temperatures.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening agent in doughnuts, cakes and other prepared mixes.


In cured meats, Food Grade Sodium Acid Pyrophosphate / SAPP 28 speeds the conversion of sodium nitrite to nitrite by forming the nitrous acid intermediate, and can improve water-holding capacity.
In leather treatment, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used to remove iron stains on hides during processing.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.
When added to scalding water, Food Grade Sodium Acid Pyrophosphate / SAPP 28 facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 in petroleum production, it can be used as a dispersant in oil well drilling muds.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can also be found in frozen hash browns and other potato products, where it is used to keep the color of the potatoes from darkening.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as fast starter, water retention agent, quality improver, used in bread, biscuits and other baked food and meat, aquatic products, etc
Food Grade Sodium Acid Pyrophosphate / SAPP 28 enhances texture, leavening, and stability in a variety of food and industrial applications.


Meticulously formulated and rigorously tested, Food Grade Sodium Acid Pyrophosphate / SAPP 28 offers unparalleled quality, reliability, and performance, making it the preferred choice for professionals and industries worldwide.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Sodium Acid Pyrophosphate.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 uses in food: Pies, Ice Creams, Puddings, Frozen Cakes, Pie Tops, Snacks, Muesli Bars, Fruit Twists, Fillings, Bases & Toppings, Instant Puddings, Self Saucing Puddings, Cake Mixes, Pancake Mixes, Muffin Mixes, Cookie Mixes, Cupcake Mixes, Baking Mixes, Instant Pasta & Sauces, Instant Soups, Waffles, Cookies.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a buffering and chelating agent used in canned seafood, as a scald agent in poultry and pork, as a sequesterant in potato products, and is used to aid leavening in baked goods.
In leather treatment Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used to remove iron stains on hides during processing.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 can stabilize hydrogen peroxide solutions against oxidation.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used for cleaning with sulphamic acid in some dairy applications.
In Petroleum production, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used as a dispersant in oil well drilling muds.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an acidulant, buffering agent, and leavening agent.
Frequently used with slower-acting Food Grade Sodium Acid Pyrophosphate / SAPP 28 to increase reaction rates
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also found in browns (frozen) to keep the color of the potatoes from fading.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a slow reacting aerator acidulant in conjunction with sodium bicarbonate.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in cakes, a part of the gas is generated in the early stage, and a part of the gas is generated after heating in the later stage.


If there is too much gas in the early stage of baking, the volume will expand rapidly.
At this time, the cake tissue has not yet condensed, and the finished product is easy to collapse and the tissue is thicker, but it cannot continue to expand in the later stage.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an acidulant, buffering agent, and leavening agent.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 has a dough reaction rate of 34 - 38.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a fast acting leavening phosphate typically used in bakery applications such as cake doughnuts mixes, cake mixes, breadings, and batters.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening agent, reducing zymosis time and can also be used as a water retention agent, and a quality improver for meat and sea food processing.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used strengthen the feed nutrition .


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an acidulant, buffering agent, and leavening agent.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening agent, reducing zymosis time.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can also be used as a water retention agent, and a quality improver for meat and sea food processing.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a chemical compound that has various applications in the food industry where one of the most common is being used as a leavening agent.
Moreover, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also best used as an acidulant, emulsifier, buffering agent, and as a sequestrant


If using too much slow-speed Food Grade Sodium Acid Pyrophosphate / SAPP 28, the initial expansion will be slow, and after the product is condensed, part of the baking powder has not yet produced gas, making the cake small in size and losing the meaning of swelling.
The baking powder used for steamed buns and steamed buns needs to produce gas a little faster because the dough is relatively hard.


As a leavening agent, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is applied to roast foodstuffs to control the fermentation speed.
When applied to instant noodles, Food Grade Sodium Acid Pyrophosphate / SAPP 28 can shorten water resetting time and avoid stickiness and mushiness of the noodles.


When applied to crackers or cakes, Food Grade Sodium Acid Pyrophosphate / SAPP 28 may shorten fermentation time, lower the breakage, make the porous space in good order and therefore lengthen the shelf life.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is widely used in food processing; in the E number scheme, they are collectively designated as E450, with the disodium form designated as E450(a).


In the United States, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is classified as generally recognized as safe (GRAS) for food use.
In canned seafood, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used to maintain color and reduce purge during retorting.
Retorting achieves microbial stability with heat.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an acid source for reaction with baking soda to leaven baked goods.
In baking powder, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is often labeled as food additive E450.
In cured meats, Food Grade Sodium Acid Pyrophosphate / SAPP 28 speeds the conversion of sodium nitrite to nitrite (NO−2) by forming the nitrous acid (HONO) intermediate, and can improve water-holding capacity.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also found in frozen hash browns and other potato products, where it is used to keep the color of the potatoes from darkening.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening acid in commercial baking powder.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used creating a buffing system in the dough provides a pH of 7.3-7.5 that affects the color of the cooked product.
As Food Grade Sodium Acid Pyrophosphate / SAPP 28 acts slowly and does not react quickly with sodium bicarbonate, it is the most common acid used for baking flour products.


In addition to flour and bakery products, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in the production of biscuits, doughnut, pancakes, cakes, and baking powders
As Food Grade Sodium Acid Pyrophosphate / SAPP 28 can have a slightly bitter taste, it is important to use sufficient baking soda in the formulation of products such as cakes.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a separating agent in processed potatoes (It reduces carcinogenic chemicals called acrylamide in fried potatoes)
Food Grade Sodium Acid Pyrophosphate / SAPP 28 prevents color change in potatoes and sugar syrups.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 prevents the formation of steroid crystals in canned fish tones.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an acidulant, buffering agent, and leavening agent.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 has a dough reaction rate of 24 – 28.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is an all-purpose phosphate commonly used in prepared mixes, commercial baking powders, and cake doughnut mixes.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used in food mainly for its two properties.


Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a leavening acid which combines with baking soda to release carbon dioxide to improve the texture and volume of baked goods.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as a chelating agent to chelate iron to prevent discoloration in processed potato.


-Food uses:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a popular leavening agent found in baking powders.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 combines with sodium bicarbonate to release carbon dioxide:
Na2H2P2O7 + NaHCO3 → Na3HP2O7 + CO2 + H2O

Food Grade Sodium Acid Pyrophosphate / SAPP 28 is available in a variety of grades that affect the speed of its action.
Because the resulting phosphate residue has an off-taste, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is usually used in very sweet cakes which mask the off-taste.


-The cake class uses medium-speed type Food Grade Sodium Acid Pyrophosphate / SAPP 28, which produces a part of the gas in the early stage and then produces a part of the gas after heating.
If the initial baking gas production is too much, the volume is rapidly puffed, at this time the cake tissue has not condensed, the finished product is prone to collapse and the organization is thicker, and the latter can not continue to puff;

The fermentation used in the buns and buns, due to the relatively hard dough, needs to produce gas slightly faster, if the condensation after the production of gas too much, the finished product will appear "flowering" phenomenon.


-Potato products:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used to replace sulfur dioxide, sulfites and bisulfites to maintain the appearance and texture of cooked potato products.

The application of Food Grade Sodium Acid Pyrophosphate / SAPP 28 reduces the dark color from after-cooking darkening in cooked and processed potato products, such as in oil-blanched french fries and potato salad.

It is the naturally present or equipment iron that generates “after cooking darkening” in potatoes.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 stabilizes the color of potatoes and prevents the iron complex from forming a dark pigment due to its strong sequestering properties.



PROPERTIES OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white powder, relative density of 1.86.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is soluble in water and insoluble in ethanol.

If its aqueous solution is heated together with diluted inorganic acid, Food Grade Sodium Acid Pyrophosphate / SAPP 28 will be hydrolyzed into phosphoric acid.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is hydroscopic,and when absorbing humidity it will become into a product with hexa-hydrates.

If Food Grade Sodium Acid Pyrophosphate / SAPP 28 is heated at a temperature above 220℃.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 will decomposed into sodium meta phosphate.



IS FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28 SAFE IN FOOD:
Studies have shown that people over the age of 18 are recommended to consume 700mg of phosphorus per day.
This intake can supply enough phosphorus for the formation of healthy bones and the processing of cellular energy.

Excessive amounts may lead to loss of bone mineral density and the ability to fully absorb dietary calcium.
Excessive phosphate intake may cause hyperphosphatemia, leading to hypocalcemia or other serious electrolyte imbalances.
Therefore, pyrophosphoric acid can’t be used in excess in food processing.

Since Food Grade Sodium Acid Pyrophosphate / SAPP 28 or other phosphate food additives are dispersed in the prepared food in a standard amount, the intake of phosphorus is difficult to exceed the standard dose required by the human body.



IS FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28 SAFE USED IN FOOD?
Sodium pyrophosphate or Food Grade Sodium Acid Pyrophosphate / SAPP 28 are edible phosphates, which are helpful for baking and fermentation, such as baking powder.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can help prevent food from discoloration, such as, used for peeled potatoes.

Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a component of baking powder, naturally fermented flour and corn flour.
Commercially, Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used as an ingredient for pre-made cakes, puddings, waffles, pancakes and muffins.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 can also be added to frozen dough products, flavored milk, bacon, potato products and canned fish.



SOLUBILITY OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
10g/100ml, 20°C in water.
The PH value of 1% solution of Food Grade Sodium Acid Pyrophosphate / SAPP 28 is 4-4.5.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is insoluble in ethanol.



PROPERTIES OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
*Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white powder;
*Relative density of Food Grade Sodium Acid Pyrophosphate / SAPP 28 is 1.86;
*Food Grade Sodium Acid Pyrophosphate / SAPP 28 is soluble in water and insoluble in ethanol;
*If its aqueous solution is heated together with diluted inorganic acid, Food Grade Sodium Acid Pyrophosphate / SAPP 28 will be hydrolyzed into phosphoric acid;
*Food Grade Sodium Acid Pyrophosphate / SAPP 28 is hydroscopic, and when absorbing humidity it will become into a product with hexa-hydrates;
*If Food Grade Sodium Acid Pyrophosphate / SAPP 28 is heated at a temperature above 220°C, it will be decomposed into sodium meta phosphate.



BENEFITS OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
*Non- aluminum.
*White free-flowing crystalline powder.
*Would hydrolyze to sodium orthophosphate if exposed to environment.
*Excellent leavening acid.
*Food Grade Sodium Acid Pyrophosphate / SAPP 28 is made of thermal process phosphoric acid, will release more CO2 rapidly.
*Food Grade Sodium Acid Pyrophosphate / SAPP 28 has no bitter taste and a good smell.



ADVANTAGES OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
•Food Grade Sodium Acid Pyrophosphate / SAPP 28 acts as a general buffer and acidifying agent in cleaning formulations.
•Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used for stabilization of Hydrogen peroxide solution.
•Food Grade Sodium Acid Pyrophosphate / SAPP 28 is used to remove iron stains during leather tanning.
•Food Grade Sodium Acid Pyrophosphate / SAPP 28 can be used to furnish acidity to product reactions and its specific slow acting properties are extremely valuable in commercial baking powder.
•Food Grade Sodium Acid Pyrophosphate / SAPP 28 is also used in electroplating and slurry thinning



PHYSICAL AND CHEMICAL PROPERTIES OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white monoclinic crystalline powder or molten solid.
The relative density of Food Grade Sodium Acid Pyrophosphate / SAPP 28 was 1.86.

Food Grade Sodium Acid Pyrophosphate / SAPP 28 is soluble in water, insoluble in ethanol.
The aqueous solution of Food Grade Sodium Acid Pyrophosphate / SAPP 28 is hydrolyzed to phosphoric acid by heating with dilute inorganic acid.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is slightly hygroscopic and forms six crystalline hydrates after water absorption.

Sodium metaphosphate is decomposed when heated above 220 °c.
Aluminum and/or calcium salts may be included in appropriate amounts to control the rate of reaction when used as a bulking agent.



FUNCTIONS OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
At first, when the moisture is added to form dough, Food Grade Sodium Acid Pyrophosphate / SAPP 28 reacts with sodium bicarbonate to produce carbon dioxide gas.
Also, pyrophosphate during reaction with sodium bicarbonate creates ionic bounds with starch and protein of dough.

Food Grade Sodium Acid Pyrophosphate / SAPP 28 also dissolves readily to provide anion, anionic pyrophosphate, which interferes with proteins in a well-cooked system to create a moist tissue.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 regulates the reaction rate at the desired level with using specific production techniques.



NUTRITIONAL VALUE OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
21g of sodium and 28g of phosphorus are available in 100g of Food Grade Sodium Acid Pyrophosphate / SAPP 28.
FDA regulations
In the United States, Food Grade Sodium Acid Pyrophosphate / SAPP 28 has been approved as a versatile food ingredient commonly known as Safe Food (GRAS).



HOW IS FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28 MADE?
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a condensed phosphate, commonly synthesized by the neutralization of phosphoric acid with sodium hydroxide or sodium carbonate at the ratio of 1:1 to produce monosodium phosphate (NaH2PO4), and then heated approximately 250°C to remove the water.
2 NaH2PO4 → Na2H2P2O7 + H2O



PROPERTIES OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is a white free-flowing crystalline powder or granular.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 would hydrolyze to sodium orthophosphate if exposed to the environment.



CHARACTER OF FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
Food Grade Sodium Acid Pyrophosphate / SAPP 28 is white monoclinic system crystalline powder or fused mass.
Food Grade Sodium Acid Pyrophosphate / SAPP 28 has accessibility, easily soluble in water, insoluble in ethanol.



PHYSICAL and CHEMICAL PROPERTIES of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
CAS Number: 68915-31-1
PubChem: 24451
EC Number: 231-835-0
Chemical Formula: Na2H2P2O7
Appearance Format: Powder
Color: White
Odor: Odorless
PH value at 20 ° C (10 g / l): 4,0 - 4,7
Melting point / Melting range: 220 ° C
Density at 20 ° C: 1.1 g / cm³
Soluble in water with solubility solubility.
Chemical formula: Na2H2P2O7

Molecular Weight: 221.94
White crystalline powder or granules
Soluble in water
Appearance: White powder or granule
Assay (Na2H2P2O7) %: ≥95
Arsenic (As) %: ≤0.0003
Lead (Pb) %: ≤0.0002
Fluoride (F) %: ≤0.001
pH (1% sol.): 3.5-4.5
Water insoluble %: ≤0.1
Loss on ignition %: ≤0.5
Chemical formula: Na2H2P2O7
Molar mass: 221.936 g·mol−1
Appearance: White odorless powder

Density: 2.31 g/cm3
Melting point: > 600 °C
Solubility in water: 11.9 g/(100 mL) (20 °C)
Refractive index (nD): 1.4645 (hexahydrate)
Hazards:
Flash point: Non-flammable
Formula: Na2H2P2O7
Molecular weight: 221.94
CAS No.: 7758-16-9
EINCS No.: 231-835-0
EEC Classification: E 450(i)
Appearance: White fine powder.

Shelf life: 24 months in original package, under dry and cool storage conditions.
Maximum stack height: 18 months in original package, under dry and cool storage conditions.
CAS: 7758-16-9
EINECS: 231-835-0
InChI: InChI=1/2Na.H4O7P2/c;;1-8(2,3)7-9(4,5)6/h;;(H2,1,2,3)(H2,4,5,6)/q2*+1;/p-4
Molecular Formula: H2Na2O7P2
Molar Mass: 221.94
Density: (hexahydrate) 1.86
Melting Point: decomposes 220℃ [MER06]
Water Solubility: Fully miscible in water. Insoluble in alcohol and ammonia.
Solubility: H2O: 0.1M at 20°C, clear, colorless
Vapor Pressure: 0 Pa at 20℃

Appearance: white powder
Color: White to Off-White
Maximum wavelength (λmax): ['λ: 260 nm Amax: 0.11', 'λ: 280 nm Amax: 0.09']
Merck: 13,8643
PH: 3.5-4.5 (20℃, 0.1M in H2O, freshly prepared)
Storage Condition: -70°C
Stability: Stable
Synonyms: Disodium Dihydrogen Pyrophosphate
Chemical Formula: Na2H2P2O7
CAS number: 7758-16-9
Density: 2.31 g/cm³
Molecular Weight: 221.94 g/mol
Appearance: Fine powder
Storage Condition: Store in a cool, dry place away from direct sunlight.



FIRST AID MEASURES of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.



STABILITY and REACTIVITY of FOOD GRADE SODIUM ACID PYROPHOSPHATE / SAPP 28:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


FOOD THICKENING AGENTS
Food Thickening Agents are substances added to foods and beverages to increase their viscosity, resulting in a thicker or more gel-like consistency.
Food Thickening Agents play a crucial role in modifying the texture and mouthfeel of a wide range of food products.
Food Thickening Agents are used for various purposes, including improving the stability of emulsions, preventing separation of ingredients, and enhancing the overall sensory experience of the food.

Xanthan Gum: CAS Number: 11138-66-2, Guar Gum: CAS Number: 9000-30-0, Carrageenan: CAS Number: 9000-07-1, Agar-Agar: CAS Number: 9002-18-0, Gelatin: CAS Number: 9000-70-8, Pectin: CAS Number: 9000-69-5, Carboxymethyl Cellulose (CMC): CAS Number: 9004-32-4, Konjac Flour (Glucomannan): CAS Number: 37220-17-0, Locust Bean Gum (Carob Gum): CAS Number: 9000-40-2, Gellan Gum: CAS Number: 71010-52-1, Acacia Gum (Gum Arabic): CAS Number: 9000-01-5, Methylcellulose: CAS Number: 9004-67-5, Polydextrose: CAS Number: 68424-04-4, Sodium Alginate: CAS Number: 9005-38-3, Hyaluronic Acid: CAS Number: 9004-61-9.

Synonyms:
Thickening agent;Rheovis AS 1125,Trees/seeds (exudates/flours), Gum Arabic (E414), Carbo/locust bean gum (E410), Guar gum (E412), Plants (fragments), Pectin (E440), Sodium carboxymethyl cellulose (E466), Seaweeds (cell walls), Agars (E406), Alginates (E400-404), Carrageenans (E407), Microorganisms (fermentations), Gellan gum (E418), Xanthan gum (E415).

A Food Thickening Agents or thickener is a substance which can increase the viscosity of a liquid without substantially changing its other properties.
Edible thickeners are commonly used to thicken sauces, soups, and puddings without altering their taste; thickeners are also used in paints, inks, explosives, and cosmetics.
Food Thickening Agents may also improve the suspension of other ingredients or emulsions which increases the stability of the product.

Food Thickening Agents are often regulated as food additives and as cosmetics and personal hygiene product ingredients.
Some Food Thickening Agents are gelling agents (gellants), forming a gel, dissolving in the liquid phase as a colloid mixture that forms a weakly cohesive internal structure.
Others act as mechanical thixotropic additives with discrete particles adhering or interlocking to resist strain.

Food Thickening Agents can also be used when a medical condition such as dysphagia causes difficulty in swallowing.
Thickened liquids play a vital role in reducing risk of aspiration for dysphagia patients.
Many other Food Thickening Agents are used as thickeners, usually in the final stages of preparation of specific foods.

These Food Thickening Agents have a flavor and are not markedly stable, thus are not suitable for general use.
However, they are very convenient and effective, and hence are widely used.
Food Thickening Agents may be more or less suitable in a given application, due to differences in taste, clarity, and their responses to chemical and physical conditions.

For example, for acidic foods, arrowroot is a better choice than cornstarch, which loses thickening potency in acidic mixtures.
At (acidic) pH levels below 4.5, guar gum has sharply reduced aqueous solubility, thus also reducing its thickening capability.
If the food is to be frozen, tapioca or arrowroot are preferable over cornstarch, which becomes spongy when frozen.

A food thickener is a thickening agent that increases the viscosity of a liquid mix without interfering with its other properties.
Knowing how to thicken food is essential for preparing many recipes; most sauces, gravies, soups, and even desserts are thickened with some kind of starch.
Each Food Thickening Agents has properties best suited for specific recipes.

One of the most commonly used methods for thickening sauces and other recipes is through the gelatinization of starches.
Pure starches have greater Food Thickening Agents power and add less color to a final dish, making them ideal for sauces, puddings, and fillings.
Food Thickening Agents have become an emerging trend for food allergy-conscious bakeries and restaurants.

Food Thickening Agents are particularly important in gluten-free baking because they mimic the "sticky" effects of gluten and create a pleasant texture in baked goods.
Food Thickening Agents tend to be odorless, tasteless, and because they are used in small quantities, contribute few to no calories.
They are derived primarily from natural sources like plants and seaweeds.

Others are produced using bacterial fermentation or chemical modification.
Food Thickening Agents, alginin and carrageenan are polysaccharides extracted from algae, xanthan gum is a polysaccharide secreted by the bacterium Xanthomonas campestris, and carboxymethyl cellulose is a synthetic gum derived from cellulose.
Proteins used as food thickeners include collagen, egg whites, and gelatin.

Other Food Thickening Agents act on the proteins already present in a food; for example sodium pyrophosphate, which acts on casein in milk during the preparation of instant pudding.
Food Thickening Agents are food additives used to thicken and stabilize various foods, like jellies, desserts and candies.
The agents provide the foods with texture through formation of a gel. Some stabilizers and thickening agents are gelling agents.

Typical gelling agents include natural gums, starches, pectins, agar-agar and gelatin. Often they are based on polysaccharides or proteins.
Food Thickening Agents produces a very clear gel with light residual taste.
Gelatin sheets disperse easily with no residual taste, but powdered form may have some taste.

Kappa carragreenan may include potassium chloride to improve the gelling process and produces a clear product with very little aftertaste.
Iota carrageenan contains sodium chloride which improves gel formation.
Food Thickening Agents a medium viscosity gel but may have some aftertaste.

High-methoxy pectin is one of the most widely used gelling agents in food processing.
Food Thickening Agents reacts with some sugars and acids and sometimes includes minerals to improve gelling process.
Low-methoxy pectin reacts with calcium, and is used for the preparation of low sugar jams.

Functional flours are produced from specific cereal variety (wheat, maize, rice or other) conjugated to specific heat treatment able to increase stability, consistency and general functionalities.
These functional flours are resistant to industrial stresses such as acidic pH, sterilisation, freeze conditions, and can help food industries to formulate with natural ingredients.
For the final consumer, these ingredients are more accepted because they are shown as "flour" in the ingredient list.

Flour is often used for thickening gravies, gumbos, and stews.
The most basic type of thickening agent, flour blended with water to make a paste, is called whitewash.
Food Thickening Agents must be cooked in thoroughly to avoid the taste of uncooked flour.

Roux, a mixture of flour and fat (usually butter) cooked into a paste, is used for gravies, sauces and stews.
Cereal grains (oatmeal, couscous, farina, etc.) are used to thicken soups.
Yogurt is popular in Eastern Europe and Middle East for thickening soups.

Soups can also be thickened by adding grated starchy vegetables before cooking, though these will add their own flavour.
Tomato puree also adds thickness as well as flavour.
Egg yolks are a traditional sauce Food Thickening Agents in professional cooking; they have rich flavor and offer a velvety smooth texture but achieve the desired thickening effect only in a narrow temperature range.

Overheating easily ruins such a sauce, which can make egg yolk difficult to use as a thickener for amateur cooks.
Other Food Thickening Agents used by cooks are nuts (including rehan) or glaces made of meat or fish.
Food Thickening Agents derived from corn.

Food Thickening Agents is neutral in flavor and widely used in both sweet and savory dishes.
Extracted from potatoes, Food Thickening Agents is often used as a gluten-free thickening alternative.
Derived from the roots of certain plants, arrowroot is a clear and neutral thickening agent, suitable for use in sauces and desserts.

Commonly used in cooking and baking, wheat flour thickens when heated.
Food Thickening Agents is often used to make roux, a mixture of flour and fat.
A gluten-free alternative to wheat flour, often used in Asian cuisines for thickening.

Derived from animal collagen, gelatin is a versatile thickening agent that forms a gel-like substance when mixed with water.
Food Thickening Agents is commonly used in desserts, gummies, and certain savory dishes.
Food Thickening Agents, pectin is a natural thickening agent used in the production of jams, jellies, and fruit preserves.

A vegetarian alternative to gelatin, Food Thickening Agents is derived from seaweed.
Food Thickening Agents forms a gel when dissolved in hot water and is commonly used in desserts.
Extracted from guar beans, guar gum is a powerful Food Thickening Agents and stabilizer often used in various food products, including sauces and ice creams.

Produced through fermentation, xanthan gum is a polysaccharide that works as a thickening and stabilizing agent in a wide range of food products.
Extracted from seaweed, carrageenan is used as a Food Thickening Agents and gelling agent in dairy products, desserts, and some processed foods.
As mentioned earlier, Food Thickening Agents is a cellulose derivative used as a thickener and stabilizer in various food products.

Extracted from the roots of the cassava plant, tapioca starch is often used as a thickening agent in puddings and sauces.
Many thickening agents require extra care in cooking.
Some starches lose their thickening quality when cooked for too long or at too high a temperature; on the other hand, cooking starches too short or not hot enough might lead to an unpleasant starchy taste or cause water to seep out of the finished product after cooling.

Also, higher viscosity causes foods to burn more easily during cooking.
As an alternative to adding more Food Thickening Agents, recipes may call for reduction of the food's water content by lengthy simmering.
When cooking, it is generally better to add thickener cautiously; if over-Food Thickening Agents, more water may be added but loss of flavour and texture may result.

Food Thickening Agents can be important for people facing medical issues with chewing or swallowing, as foods with a thicker consistency can reduce the chances of choking, or of inhalation of liquids or food particles, which can lead to aspiration pneumonia.
Fumed silica and similar products form stiff microscopic chains or fibers which interlock or agglomerate into a mass, holding the associated liquid by surface tension, but which can separate or slide when sufficient force is applied.
This causes the thixotropic or shear-thinning property (also frequently exhibited by gels), where the viscosity is non-Newtonian and becomes lower as the shearing force or time increases; their usefulness is primarily that the resulting increase in viscosity is large compared to the quantity of silica added.

Food Thickening Agents is generally accepted as safe as a food additive and is frequently used in cosmetics.
Additives such as precipitated silica, fine talc, or chalk also meet the definition of thickening agent in that they increase viscosity and body while not affecting the target property of a mixture.
One of the main use of Food Thickening Agents is in the paint and printing industries, which depend heavily on rheology modifiers, to prevent pigments settling to the bottom of the can, yielding inconsistent results.

Water based formulas would be nearly impossible with the exception of India ink and the few other water-soluble pigments, but these would have very little coverage and at best would stain wood slightly.
All modern paints and inks will have some pigment added at the factory for opacity and to control the specularity of the finish, from matte to high gloss, dependent on thickener used, but more so on the size of the particles added as opacity modifier.
Particle sizes of 1 µm and below will be the limit of high gloss, probably confined to luxury automotive coatings, and about 100 µm particulates will make a bumpy surface on the microscopic scale, which scatters light and makes the surface appear matte.

Food Thickening Agents, or thickeners, are substances which, when added to an aqueous mixture, increase its viscosity without substantially modifying its other properties, such as taste.
They provide body, increase stability, and improve suspension of added ingredients.
Derived from the seeds of the Plantago ovata plant, psyllium husk is a soluble fiber that can be used as a thickening agent in certain food products and is also known for its health benefits.

Extracted from the root of the konjac plant, konjac flour is a low-calorie thickening agent that forms a gel when mixed with water.
Food Thickening Agents is used in some Asian cuisines and as a dietary supplement.
Obtained from the seeds of the carob tree, locust bean gum is a natural Food Thickening Agents and gelling agent often used in the food industry, including dairy products and ice cream.

Produced through bacterial fermentation, Food Thickening Agents is a versatile thickening and gelling agent used in a variety of food applications, including desserts and plant-based products.
Harvested from the sap of the Acacia senegal tree, acacia gum is a natural thickening and stabilizing agent used in the food and beverage industry.
A derivative of cellulose, methylcellulose is a non-caloric thickening agent that undergoes reversible gelation.

Food Thickening Agents is used in culinary applications and as a vegetarian alternative to gelatin.
A synthetic polymer of glucose, polydextrose is used as a low-calorie bulking and thickening agent in various food products, including baked goods and dairy.
Whey protein can be used as a Food Thickening Agents in certain liquid-based products, providing both thickness and protein content.

This category includes various thickening agents like carrageenan, guar gum, xanthan gum, and others, which are often used individually or in combination to achieve specific textures and properties in food products.
Starches that have undergone physical or chemical modifications to enhance their thickening properties.
They are commonly used in the food industry for their stability and versatility.

Uses:
A variety of hydrophilic substances act as Food Thickening Agents to increase the viscosity of liquid mixtures and solutions, and their emulsifying properties.
Thus, these Food Thickening Agents aid in maintaining the stability of the mixtures or solutions.
Four types of Food Thickening Agents are known: (a) starches, gums, casein, gelatin and phytocolloids, (b) semi-synthetic cellulose derivatives like carbon methyl cellulose, (c) polyvinyl alcohol and carboxy vinylates, and (d) bentonite, silicates and colloidal silica.

The first group is widely used in the food industry especially in ice creams, confectionaries, gravies, etc.
The other major consumers, are in the paper, adhesive, textile and detergent industries.
Food Thickening Agents used in cosmetics or personal hygiene products include viscous liquids such as polyethylene glycol, synthetic polymers such as carbomer (a trade name for polyacrylic acid) and vegetable gums.

Some Food Thickening Agents may also function as stabilizers when they are used to maintain the stability of an emulsion.
Some emollients, such as petroleum jelly and various waxes may also function as thickening agents in an emulsion.
Food Thickening Agents like flour, cornstarch, and arrowroot are commonly used to thicken sauces and gravies, providing a smoother and more cohesive texture.

Starches such as cornstarch, potato starch, and rice flour are often used to thicken soups and stews, improving their consistency.
Gelatin, agar-agar, cornstarch, and other Food Thickening Agents are used in desserts such as puddings, custards, and fruit gels to achieve the desired texture.
In baking, flour, cornstarch, and other starches are used to thicken fillings for pies and pastries.

They also contribute to the texture of cakes and cookies.
Food Thickening Agents like guar gum, xanthan gum, and carrageenan are used in the production of dairy products such as yogurt, ice cream, and cream-based sauces.
Xanthan gum, guar gum, and carrageenan are used to stabilize and thicken certain beverages, such as smoothies, shakes, and fruit juices.

Pectin, a natural Food Thickening Agents found in fruits, is commonly used in the production of jams, jellies, and fruit preserves.
Food Thickening Agents, agar-agar, and gelatin are used in the production of candies and confectionery items to achieve specific textures.
Modified starches and other Food Thickening Agents are used in the production of processed meat products, such as sausages and meat sauces.

Inulin, psyllium husk, and other fiber-based Food Thickening Agents are used in certain dietary and health products to add bulk and improve texture.
Gluten-free flours, such as rice flour and tapioca starch, are used as Food Thickening Agents in gluten-free recipes.
Vegan alternatives like agar-agar and guar gum are used in plant-based products.

Modified starches and other gentle Food Thickening Agents are used in baby food to achieve appropriate texture and consistency.
Modified starches, xanthan gum, and other Food Thickening Agents contribute to the texture and stability of salad dressings, ketchup, and other condiments.
Sodium alginate, agar-agar, and other specialty Food Thickening Agents are used in molecular gastronomy to create unique textures and presentations in food.

Food Thickening Agents, not polyvinylacetate which is used in adhesives such as wood glue.
Food Thickening Agents are dispersed in the paint or ink liquid at an early stage in the mix, as it does not affect rheology unless the pH is low.
Boric acid is usually used to initiate polymerization after the pigment is added (the pigment "grind" stage) and dispersed, the mixture is thickened while stirring to maintain homogeneous consistency.

Often this stage is problematic since air is entrained by all but the lowest shear impellers, which are inadequate for this purpose, instead antifoam additives are used to control air bubbles, which continue to be a benefit during paint application.
Air entrainment during mixing is not unique to PVA—in fact hardly a formula for paint exists that doesn't at least require some care in mixing.
Clays - attapulgite which also disperses suspensions, bentonite (both flocculating and non-flocculating), and other montmorillonite clays.

Usually clays, when dry, exist as a very fine powder, facilitating dispersion and compatibility with other ingredients.
Food Thickening Agents generally make matte surfaces, in spite of their fine particulate nature.
Not only paints and inks, but other industries such as pharmaceutical, construction, and cosmetics, especially hair styling aids and facial detoxifying masks increasingly favor bentonite and attapulgite clays over other rheology modifiers, dispersion aids, opacifying fillers, antifoam, and numerous niche uses which exploit the numerous inherent qualities which have drawn artisans to this material.

Food Thickening Agents are sustainably sourced and do not involve any egregious environmental damage, which were among the cheapest bulk materials until recently, when the pricing went up steadily, following the upsurge in its use pattern.
Food Thickening Agents, are chemically substituted cellulose macromolecules.
The hydroxyl groups are substituted by other functional groups, such as methyl or propyl.

The amount of substitution and molecular weight determine viscosity of the solution, assuming concentration stays the same; adding more also increases viscosity.
Food Thickening Agents like carrageenan, guar gum, and xanthan gum are often used in plant-based milk alternatives (such as almond milk or soy milk) to mimic the texture of traditional dairy milk.
Starches such as cornstarch and tapioca are used to Food Thickening Agents fruit fillings in pies, pastries, and desserts.

Food Thickening Agents are used in the production of ready-to-eat meals, helping to achieve a desirable consistency in dishes like casseroles, curries, and pasta sauces.
Modified starches and gums are commonly used in the production of frozen foods, helping to maintain texture and prevent ice crystal formation.
Certain Food Thickening Agents are used in pet foods to improve the texture and palatability of canned or pouched products.

Inulin, xanthan gum, and other Food Thickening Agents are used in the production of nutritional supplements to enhance the texture of shakes and drinks.
Food Thickening Agents may be used in specialized dietary and medical foods, especially those designed for individuals with swallowing difficulties or specific nutritional needs.
Chefs use various Food Thickening Agents in culinary arts for food texturization, creating foams, gels, and other unique textures in dishes.

Starches, such as cornstarch, are used to Food Thickening Agents pasta sauces, providing a smooth and consistent texture.
Food Thickening Agents are incorporated into functional foods, such as meal replacements or protein bars, to improve their mouthfeel and texture.
Modified starches and gums contribute to the Food Thickening Agents and spreadability of dips and spreads, including hummus and cream cheese.

Modified starches can be used in batter coatings for fried foods to improve adhesion and texture.
Food Thickening Agents like agar-agar and foaming agents are used in molecular gastronomy to create culinary foams with unique textures.
Food Thickening Agents are often used in low-fat or reduced-calorie products to compensate for the reduced fat content and maintain a desirable texture.

Molecular mixologists use Food Thickening Agents to enhance the texture and presentation of cocktails, creating innovative and visually appealing drinks.
Sulfonates - Sodium or calcium salts, good water retention, versatile, and highly efficient.
Gums - guar, xanthan, cellulose, locust bean, and acacia are the main ones.

Saccharides - carrageenan, pullulan, konjac, and alginate, sometimes called hydrocolloids, these Food Thickening Agents are extremely versatile and specific in function—each has a series of grades or types which behave differently, for example kappa carrageenan will form strong gels (potassium activated) but iota carrageenan will not form gels and only thickens.
Modified castor oil - much like cellulose, castor oil has hydroxyl groups, unlike other oils which at most have double bonds, which castor oil also has, but most substitutions occur at the hydroxyl moieties, allowing exotic derivatives with myriad properties.
The most recent advances in rheology modifiers have been in this category. The BASF corporation has a new line based on castor oil derivatives, for example.

Widely used in the cosmetic and skincare industry, hyaluronic acid can also be used as a Food Thickening Agents in some food and beverage formulations.
A soluble fiber extracted from chicory root, inulin can be used as a Food Thickening Agents and provides dietary fiber to the final product.
While primarily used in pharmaceuticals and cosmetics, certain PEG derivatives can be employed as Food Thickening Agents in specific food applications.

Produced by the partial hydrolysis of starch, dextrin is used as a Food Thickening Agents and can also act as a binder in food products.
Often used as a sequestrant and acidifier, GDL can also contribute to the Food Thickening Agents of certain food products.
Obtained from the sap of the Astragalus plant, tragacanth gum is a natural Food Thickening Agents used in the food industry, especially in confectionery.

Extracted from brown seaweed, sodium alginate is used as a Food Thickening Agents and gelling agent, particularly in molecular gastronomy.
Derived from animal connective tissues, collagen can be used as a thickening agent in certain culinary applications.

Various vegetable gums, obtained from plants, are used as thickening agents in the food industry.
Extracted from fenugreek seeds, fenugreek gum is used as a Food Thickening Agents and stabilizing agent in some food applications.

Safety Profile:
Some individuals may be allergic or sensitive to specific Food Thickening Agents.
For example, individuals with sensitivities to gluten should avoid thickening agents derived from wheat, barley, or rye.
In some cases, excessive consumption of certain Food Thickening Agents, especially those high in dietary fiber, may lead to gastrointestinal discomfort, bloating, or flatulence.

Some thickening agents, particularly those high in carbohydrates, can impact blood sugar levels.
Individuals with diabetes or those monitoring their blood sugar levels should be mindful of their intake.

Some commercially available thickening agents, especially in processed foods, may contribute to the overall sodium content of a product.
Excessive sodium intake can be a concern for individuals with certain health conditions.
The sourcing and processing of thickening agents can vary, and there may be concerns about potential contaminants, depending on the quality and origin of the raw materials.

In some cases, Food Thickening Agents are used in combination with other food additives.
Adverse reactions may occur in individuals sensitive to specific additives or when additives are consumed in excess.
FORAL AX E
Foral AX E Technical Datasheet Foral AX E is an alcohol soluble, fully hydrogenated rosin used as a tackifier. Offers good resistance to oxidation, medium softening point and very light color. Used in assembly, bookbinding, caulks, sealants, contact adhesives, case & carton sealing closings and hot-melt adhesives. Compatible with natural and synthetic waxes, resins, rubber, drying and non-drying alkyds, blow castor oil, ethylcellulose, synthetic elastomers, thermoplastic polymers and copolymers. Foral AX E is also suitable for laminating, non-wovens, non food contact packaging, pressure sensitive adhesives, solvent-borne adhesives, tapes, labels and water-borne adhesives. Product Type Tackifiers > Rosins > Hydrogenated Rosins Chemical Composition Fully hydrogenated rosin Product Status COMMERCIAL Foral AX E - Fully Hydrogenated Rosin Product description Foral AX E fully hydrogenated rosin is a thermoplastic, acidic resin produced by hydrogenating rosin to an exceptionally high degree. It is the palest, most highly stabilized rosin commercially available. Compared with Staybelite™ resin-E partially hydrogenated rosin, a hydrogenated rosin long established and widely used for its pale color and high oxidation resistance, Foral AX E has better initial color and color retention, and even greater resistance to oxidation. It is especially indicated as the tackifier and resin modifier in solvent adhesives and hot-melt applied coatings and adhesives that must excel in these properties. It is also used in UV cured acrylics to improve adhesion to low surface energy substrates. Applications/uses Adhesives/sealants-B&C Bookbinding Caps & lids non-food contact Carpet construction Case and carton closures Commerical printing inks Film modification Hygiene adhesives Labels non food contact Packaging tape Polymer modification Protective coatings Road markings Roofing ingredients Solder flux Solvent borne packaging adhesives Specialty tape Wire/cable Key attributes Alcohol-soluble Compatible with UV acrylic adhesives Excellent resistance to oxidation High acid number Improved adhesion to low surface energy substrates Medium softening point Thermoplastic hydrogenated resin Very light color Foral 85-E CG - Hydrogenated Rosinate Foral™ 85-E CG hydrogenated rosinate is a cosmetic grade resin derived from the esterification of a highly stabilized gum rosin and glycerol. This light amber, thermoplastic resin has excellent resistance to oxidation and discoloration caused by heat and aging. Foral 85-E - Ester of Hydrogenated Rosin Foral™ 85-E ester of hydrogenated rosin is a very pale, thermoplastic ester resin derived from glycerol and a highly stabilized rosin that has outstanding resistance to oxidation, and to discoloration caused by heat and aging. Foral 105-E CG - Hydrogenated Rosinate Foral™ 105-E CG hydrogenated rosinate is a cosmetic grade resin derived from the esterification of a highly stabilized gum rosin and pentaerythritol. This thermoplastic resin has excellent resistance to oxidation and discoloration caused by heat and aging. Foral 105-E - Ester of Hydrogenated Rosin Foral™ 105-E ester of hydrogenated rosin is a pale, thermoplastic ester resin derived from pentaerythritol and a highly stabilized rosin. Foral AX E - Fully Hydrogenated Rosin Foral™ AX-E fully hydrogenated rosin is a thermoplastic, acidic resin produced by hydrogenating rosin to an exceptionally high degree. It is the palest, most highly stabilized rosin commercially available. Foral AX-E Technical Datasheet Fully hydrogenated rosin. Possesses excellent resistance to oxidation and medium softening point. Has better initial color and color retention. Product Type Alkyd Resins > Modified > Rosins Chemical Composition Fully hydrogenated rosin CAS Number 65997-06-0 Foral AX E is a thermoplastic, acidic resin produced by hydrogenating rosin to an exceptionally high degree. It is most highly stabilized rosin. Hydrogenated resin Foral AX Foral AX rosin is a thermoplastic, acidic resin produced by hydrogenating wood rosin to an exceptionally high degree. Key properties It is the palest, most highly stabilized rosin commercially available. Compared with Staybelite resin, a hydrogenated rosin long established and widely used for its pale color and high oxidation stability, Foral AX resin has better initial color and color retention, and even greater resistance to oxidation. Applications Foral AX resin is especially indicated as the tackifier and resin modifier in solvent adhesives and hot melt applied coatings and adhesives that must excel in these properties. Foral AX resin is particularly suited to food contact applications. Tackifier or modifier for the following adhesive systems: hot melt/pressure-sensitive/solvent-based/emulsion-based/sealants Modifier in solvent-based or heat-sealable coatings Component of thermoplastic compounds and hot melt depilatory waxes Plastifier/modifier of natural and synthetic rubber goods Foral AX Foral AX rosin is a thermoplastic, acidic resin produced by hydrogenating wood rosin to an exceptionally high degree. It is the palest, most highly stabilized rosin commercially available. Compared with Staybelite resin, a hydrogenated rosin long established and widely used for its pale color and high oxidation stability, Foral AX resin has better initial color and color retention, and even greater resistance to oxidation. It is especially indicated as the tackifier and resin modifier in solvent adhesives and hot melt applied coatings and adhesives that must excel in these properties. Foral AX resin is particularly suited to food contact applications. Applications Tackifier or modifier for adhesive systems, including: - Hot melt - Pressure sensitive - Solvent - Emulsion - Sealant compounds Modifier in solvent-based or heat-sealable coatings Component of thermoplastic compounds and hot melt depilatory waxes Plasticizer/modifier of natural and synthetic rubber goods Benefits Highest degree of hydrogenation available Exceptional color Excellent heat stability and color retention Good acid functionality Low odor Widely compatible with polymers and solvents Broad regulatory approval General Sales Specifications Softening Point, Ring & Ball, °C minimum 66 Color, USRG rosin scale, maximum XB Acid Number, mg KOH/g, minimum 158 Abietic acid, UV, %, maximum 0.2 Refractive index at 100 °C, maximum 1.4971
FORALYN 5020-F
FORALYN 5020-F Foralyn 5020-F is the methyl ester of hydrogenated rosin, used as a tackifier. Possesses good cutaneous tolerance and aging characteristics. Exhibits low color, low odor, wide solubility and compatibility range. Used in bookbinding, caulks, sealants, contact adhesives, hot-melt adhesives, laminating, non-wovens, non food contact packaging and pressure sensitive adhesives. Applicable for solvent-borne adhesives, tapes, labels, water-borne adhesives, case and carton sealing closings. Compatible with nitrocellulose, ethylcellulose, chlorinated rubber, PVC, vinyl acetate-chloride copolymers and polyvinyl ethers. Also compatible with water-soluble film-formers as casein and starch, natural and synthetic resins and rubber, asphalt, and waxes. Foralyn 5020-F is incompatible with cellulose acetate and polyvinyl acetate. Foralyn 5020-F CG Hydrogenated Rosinate is a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. This product is applied in depilatory wax, fragrance, lipstick and gloss. Foralyn 5020-F CG Hydrogenated Rosinate acts as a fragrance fixative and excellent plasticizer. Foralyn 5020-F is derived from a natural renewable source. Foralyn 5020-F contributes to adhesion and low vapor pressure. Possesses good oxidative stability and high gloss (high refractive index). Foralyn 5020-F has excellent solubility, compatibility with non-polar and many polar ingredients. Foralyn 5020-F CG Hydrogenated Rosinate is used in depilatory wax, fragrances, lipstick and glosses.Product Description: Foralyn 5020-F Ester of Hydrogenated Rosin, the methyl ester of hydrogenated rosin, is a light amber liquid resin. Being hydrogenated, it has marked resistance to aging. To assure minimum odor of products in which it is used, it is given a special steam-sparging treatment. Foralyn 5020-F Ester of Hydrogenated Rosin is used as a resinous plasticizer or tackifier in finished products such as adhesives, inks, and lacquers. Foralyn 5020-F CG Description of Foralyn 5020-F Foralyn 5020-F CG hydrogenated rosinate, a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. It is used in depilatory wax, fragrance, lipstick and gloss etc. Tag Archives: FORALYN 5020-F Foralyn 5020-F is a light amber liquid resinous tackifier and plasticizer, being hydrogenated, having marked resistance to aging. A consistent mild odor is assured after giving a special steam purification treatment. It is soluble in usual apolar organic solvents, alcohols and ethyl and butyl acetates, has a superior cold resistance ability and may maintain a valid viscosity under -40 deg C circumstance, forms a continuous film on skin, hair or nails. Methanol Ester of Hydrogenated Rosin | Hydrogenated Methyl Abietate | MEHR CAS: 8050-15-5 EINECS: 232-476-2 FEMA: N/A HS.CODE: 380690 Molecular Formula: C19H31COOCH3 Moleclar Weight: N/A Products & Informations of Foralyn 5020-F Foralyn 5020-F a cosmetic-grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, it is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing to both adhesion and gloss. It is the substitute for product. APPLICATIONS & USES of Foralyn 5020-F •Carrier and fixative in fragrance compounds,amber balsam cedar film formers fixer pine skin conditioning viscosity controlling agents woody •Component in chewing gum base to adjust hardness, plasticity, and chew characteristics •Resin component in adhesives, inks, floor tiles, vinyl plastics, rubber compositions, solder flux, surface active agent and related applications •removed hair wax, Component in Lipstick, lip gloss, depilatory waxes Benefits of Foralyn 5020-F excellent pigment wetting properties high boiling point high refractive index low odor low vapor pressure resistant to oxidation wide solubility and compatibility ranges Packaging of Foralyn 5020-F Iron Drum, 25kg net each, polyvinyl fluoride inner available Iron Drum, 50kg net each, polyvinyl fluoride inner available Iron Drum, 200kg net each, polyvinyl fluoride inner available Preview all the spec of packaging Storage of Foralyn 5020-F store in a cool, well-ventilated area store in a sprinklered warehouse keep container closed when not in use Remark for Foralyn 5020-F The above information is believed to be accurate and presents the best explanation currently available to us. We assume no liability resulting from above content. The technical standards are formulated and revised by customers’ requirement and us, if there are any changes, the latest specification will be executed and confirmed in the contract. Foralyn 5020-F - Ester of Hydrogenated Rosin Product description of Foralyn 5020-F Foralyn 5020-F Ester of Hydrogenated Rosin, the methyl ester of hydrogenated rosin, is a light amber liquid resin. Being hydrogenated, it has marked resistance to aging. To assure minimum odor of products in which it is used, it is given a special steam-sparging treatment. Foralyn 5020-F is used as a resinous plasticizer or tackifier in finished products such as adhesives, inks, and lacquers. Foralyn 5020-F hydrogenated rosin resin Foralyn 5020-F hydrogenated rosin resins are a resin family based on stabilized rosin for adhesives and coatings. They are available with a softening point range from liquid to 110°C. The hydrogenation of Foralyn 5020-F improves its compatibility with adhesive base polymers, in contrast to non-hydrogenated rosin-resins, which results in improved adhesive performance. In particular Foralyn 5020-F hydrogenated rosin resins impart superior adhesion and excellent cohesion to adhesives based on styrenic block copolymers and acrylic polymers, especially at higher temperatures. Methyl Hydrogenated Rosinate. Foralyn 5020-F CG Hydrogenated Rosinate acts as a fragrance fixative and excellent plasticizer. It is derived from a natural renewable source. It contributes to adhesion and low vapor pressure. Possesses good oxidative stability and high gloss (high refractive index). It has excellent solubility, compatibility with non-polar and many polar ingredients. Foralyn 5020-F CG Hydrogenated Rosinate is used in depilatory wax, fragrances, lipstick and glosses. Foralyn 5020-F hydrogenated rosin and rosin esters are a resin family based on stabilized rosin for adhesives and coatings. Foralyn 5020-F are available with a softening point range from liquid to 11°C. The hydrogenation of Foralyn 5020-F improves its compatibility with adhesive base polymers, in contrast to non-hydrogenated rosin-resins, which results in improved adhesive performance. In particular Foralyn 5020-F hydrogenated rosin resins impart superior adhesion and excellent cohesion to adhesives based on styrenic block copolymers and acrylic polymers, especially at higher temperatures. Foralyn 5020-F 90 and Foralyn 5020-F 110 are of special interest due to their exceptional light color, thermal color stability and low oxygen uptake. Foralyn 5020-F CG is particularly suitable for cosmetic, personal care and fragrance applications. Foralyn 5020-F is the methyl ester of hydrogenated rosin, used as a tackifier. Possesses good cutaneous tolerance and aging characteristics. Exhibits low color, low odor, wide solubility and compatibility range. Used in bookbinding, caulks, sealants, contact adhesives, hot-melt adhesives, laminating, non-wovens, non food contact packaging and pressure sensitive adhesives. Applicable for solvent-borne adhesives, tapes, labels, water-borne adhesives, case and carton sealing closings. Compatible with nitrocellulose, ethylcellulose, chlorinated rubber, PVC, vinyl acetate-chloride copolymers and polyvinyl ethers. Also compatible with water-soluble film-formers as casein and starch, natural and synthetic resins and rubber, asphalt, and waxes. Foralyn 5020-F is incompatible with cellulose acetate and polyvinyl acetate. Foralyn 5020-F CG Hydrogenated Rosinate is a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. This product is applied in depilatory wax, fragrance, lipstick and gloss. Foralyn 5020-F is the methyl ester of hydrogenated rosin, used as a tackifier. Possesses good cutaneous tolerance and aging characteristics. Exhibits low color, low odor, wide solubility and compatibility range. Used in bookbinding, caulks, sealants, contact adhesives, hot-melt adhesives, laminating, non-wovens, non food contact packaging and pressure sensitive adhesives. Applicable for solvent-borne adhesives, tapes, labels, water-borne adhesives, case and carton sealing closings. Compatible with nitrocellulose, ethylcellulose, chlorinated rubber, PVC, vinyl acetate-chloride copolymers and polyvinyl ethers. Also compatible with water-soluble film-formers as casein and starch, natural and synthetic resins and rubber, asphalt, and waxes. Foralyn 5020-F is incompatible with cellulose acetate and polyvinyl acetate. Foralyn 5020-F CG Hydrogenated Rosinate Foralyn 5020-F. Foralyn 5020-F CG Hydrogenated Rosinate acts as a fragrance fixative and excellent plasticizer. It is derived from a natural renewable source. Foralyn 5020-F contributes to adhesion and low vapor pressure. Possesses good oxidative stability and high gloss (high refractive index). It has excellent solubility, compatibility with non-polar and many polar ingredients. Foralyn 5020-F CG Hydrogenated Rosinate is used in depilatory wax, fragrances, lipstick and glosses. Foralyn 5020-F CG Hydrogenated Rosinate Properties Product Description: Foralyn 5020-F CG Hydrogenated Rosinate, a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. Foralyn 5020-F Hydrogenated Rosin Esters Foralyn 5020-F hydrogenated rosin and rosin esters are a resin family based on stabilized rosin for adhesives and coatings. They are available with a softening point range from liquid to 11°C. The hydrogenation of Foralyn 5020-F improves its compatibility with adhesive base polymers, in contrast to non-hydrogenated rosin-resins, which results in improved adhesive performance. In particular Foralyn 5020-F hydrogenated rosin resins impart superior adhesion and excellent cohesion to adhesives based on styrenic block copolymers and acrylic polymers, especially at higher temperatures. Foralyn 5020-F Ester of Hydrogenated Rosin, the methyl ester of hydrogenated rosin, is a light amber liquid resin. Being hydrogenated, it has marked resistance to aging. To assure minimum odor of products in which it is used, it is given a special steam-sparging treatment. Foralyn 5020-F is used as a resinous plasticizer or tackifier in finished products such as adhesives, inks, and lacquers. Foralyn 5020-F is the methyl ester of hydrogenated rosin, used as a tackifier. Possesses good cutaneous tolerance and aging characteristics. Exhibits low color, low odor, wide solubility and compatibility range. Used in bookbinding, caulks, sealants, contact adhesives, hot-melt adhesives, laminating, non-wovens, non food contact packaging and pressure sensitive adhesives. Applicable for solvent-borne adhesives, tapes, labels, water-borne adhesives, case and carton sealing closings. Compatible with nitrocellulose, ethylcellulose, chlorinated rubber, PVC, vinyl acetate-chloride copolymers and polyvinyl ethers. Also compatible with water-soluble film-formers as casein and starch, natural and synthetic resins and rubber, asphalt, and waxes. Foralyn 5020-F is incompatible with cellulose acetate and polyvinyl acetate. Foralyn 5020-F CG Hydrogenated Rosinate is a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. This product is applied in depilatory wax, fragrance, lipstick and gloss. Foralyn 5020-F CG Hydrogenated Rosinate acts as a fragrance fixative and excellent plasticizer. Foralyn 5020-F is derived from a natural renewable source. Foralyn 5020-F contributes to adhesion and low vapor pressure. Possesses good oxidative stability and high gloss (high refractive index). Foralyn 5020-F has excellent solubility, compatibility with non-polar and many polar ingredients. Foralyn 5020-F CG Hydrogenated Rosinate is used in depilatory wax, fragrances, lipstick and glosses.Product Description: Foralyn 5020-F Ester of Hydrogenated Rosin, the methyl ester of hydrogenated rosin, is a light amber liquid resin. Being hydrogenated, it has marked resistance to aging. To assure minimum odor of products in which it is used, it is given a special steam-sparging treatment. Foralyn 5020-F Ester of Hydrogenated Rosin is used as a resinous plasticizer or tackifier in finished products such as adhesives, inks, and lacquers. Foralyn 5020-F CG Description of Foralyn 5020-F Foralyn 5020-F CG hydrogenated rosinate, a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. It is used in depilatory wax, fragrance, lipstick and gloss etc. Tag Archives: FORALYN 5020-F Foralyn 5020-F is a light amber liquid resinous tackifier and plasticizer, being hydrogenated, having marked resistance to aging. A consistent mild odor is assured after giving a special steam purification treatment. It is soluble in usual apolar organic solvents, alcohols and ethyl and butyl acetates, has a superior cold resistance ability and may maintain a valid viscosity under -40 deg C circumstance, forms a continuous film on skin, hair or nails. Methanol Ester of Hydrogenated Rosin | Hydrogenated Methyl Abietate | MEHR CAS: 8050-15-5 EINECS: 232-476-2 FEMA: N/A HS.CODE: 380690 Molecular Formula: C19H31COOCH3 Moleclar Weight: N/A Products & Informations of Foralyn 5020-F Foralyn 5020-F a cosmetic-grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, it is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing to both adhesion and gloss. It is the substitute for product. APPLICATIONS & USES of Foralyn 5020-F •Carrier and fixative in fragrance compounds,amber balsam cedar film formers fixer pine skin conditioning viscosity controlling agents woody •Component in chewing gum base to adjust hardness, plasticity, and chew characteristics •Resin component in adhesives, inks, floor tiles, vinyl plastics, rubber compositions, solder flux, surface active agent and related applications •removed hair wax, Component in Lipstick, lip gloss, depilatory waxes Benefits of Foralyn 5020-F excellent pigment wetting properties high boiling point high refractive index low odor low vapor pressure resistant to oxidation wide solubility and compatibility ranges Packaging of Foralyn 5020-F Iron Drum, 25kg net each, polyvinyl fluoride inner available Iron Drum, 50kg net each, polyvinyl fluoride inner available Iron Drum, 200kg net each, polyvinyl fluoride inner available Preview all the spec of packaging Storage of Foralyn 5020-F store in a cool, well-ventilated area store in a sprinklered warehouse keep container closed when not in use Remark for Foralyn 5020-F The above information is believed to be accurate and presents the best explanation currently available to us. We assume no liability resulting from above content. The technical standards are formulated and revised by customers’ requirement and us, if there are any changes, the latest specification will be executed and confirmed in the contract. Foralyn 5020-F - Ester of Hydrogenated Rosin Product description of Foralyn 5020-F Foralyn 5020-F Ester of Hydrogenated Rosin, the methyl ester of hydrogenated rosin, is a light amber liquid resin. Being hydrogenated, it has marked resistance to aging. To assure minimum odor of products in which it is used, it is given a special steam-sparging treatment. Foralyn 5020-F is used as a resinous plasticizer or tackifier in finished products such as adhesives, inks, and lacquers. Foralyn 5020-F hydrogenated rosin resin Foralyn 5020-F hydrogenated rosin resins are a resin family based on stabilized rosin for adhesives and coatings. They are available with a softening point range from liquid to 110°C. The hydrogenation of Foralyn 5020-F improves its compatibility with adhesive base polymers, in contrast to non-hydrogenated rosin-resins, which results in improved adhesive performance. In particular Foralyn 5020-F hydrogenated rosin resins impart superior adhesion and excellent cohesion to adhesives based on styrenic block copolymers and acrylic polymers, especially at higher temperatures. Methyl Hydrogenated Rosinate. Foralyn 5020-F CG Hydrogenated Rosinate acts as a fragrance fixative and excellent plasticizer. It is derived from a natural renewable source. It contributes to adhesion and low vapor pressure. Possesses good oxidative stability and high gloss (high refractive index). It has excellent solubility, compatibility with non-polar and many polar ingredients. Foralyn 5020-F CG Hydrogenated Rosinate is used in depilatory wax, fragrances, lipstick and glosses. Foralyn 5020-F hydrogenated rosin and rosin esters are a resin family based on stabilized rosin for adhesives and coatings. Foralyn 5020-F are available with a softening point range from liquid to 11°C. The hydrogenation of Foralyn 5020-F improves its compatibility with adhesive base polymers, in contrast to non-hydrogenated rosin-resins, which results in improved adhesive performance. In particular Foralyn 5020-F hydrogenated rosin resins impart superior adhesion and excellent cohesion to adhesives based on styrenic block copolymers and acrylic polymers, especially at higher temperatures. Foralyn 5020-F 90 and Foralyn 5020-F 110 are of special interest due to their exceptional light color, thermal color stability and low oxygen uptake. Foralyn 5020-F CG is particularly suitable for cosmetic, personal care and fragrance applications. Foralyn 5020-F is the methyl ester of hydrogenated rosin, used as a tackifier. Possesses good cutaneous tolerance and aging characteristics. Exhibits low color, low odor, wide solubility and compatibility range. Used in bookbinding, caulks, sealants, contact adhesives, hot-melt adhesives, laminating, non-wovens, non food contact packaging and pressure sensitive adhesives. Applicable for solvent-borne adhesives, tapes, labels, water-borne adhesives, case and carton sealing closings. Compatible with nitrocellulose, ethylcellulose, chlorinated rubber, PVC, vinyl acetate-chloride copolymers and polyvinyl ethers. Also compatible with water-soluble film-formers as casein and starch, natural and synthetic resins and rubber, asphalt, and waxes. Foralyn 5020-F is incompatible with cellulose acetate and polyvinyl acetate. Foralyn 5020-F CG Hydrogenated Rosinate is a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. This product is applied in depilatory wax, fragrance, lipstick and gloss. Foralyn 5020-F is the methyl ester of hydrogenated rosin, used as a tackifier. Possesses good cutaneous tolerance and aging characteristics. Exhibits low color, low odor, wide solubility and compatibility range. Used in bookbinding, caulks, sealants, contact adhesives, hot-melt adhesives, laminating, non-wovens, non food contact packaging and pressure sensitive adhesives. Applicable for solvent-borne adhesives, tapes, labels, water-borne adhesives, case and carton sealing closings. Compatible with nitrocellulose, ethylcellulose, chlorinated rubber, PVC, vinyl acetate-chloride copolymers and polyvinyl ethers. Also compatible with water-soluble film-formers as casein and starch, natural and synthetic resins and rubber, asphalt, and waxes. Foralyn 5020-F is incompatible with cellulose acetate and polyvinyl acetate. Foralyn 5020-F CG Hydrogenated Rosinate Foralyn 5020-F. Foralyn 5020-F CG Hydrogenated Rosinate acts as a fragrance fixative and excellent plasticizer. It is derived from a natural renewable source. Foralyn 5020-F contributes to adhesion and low vapor pressure. Possesses good oxidative stability and high gloss (high refractive index). It has excellent solubility, compatibility with non-polar and many polar ingredients. Foralyn 5020-F CG Hydrogenated Rosinate is used in depilatory wax, fragrances, lipstick and glosses. Foralyn 5020-F CG Hydrogenated Rosinate Properties Product Description: Foralyn 5020-F CG Hydrogenated Rosinate, a cosmetic grade resin, is the methyl ester of hydrogenated gum rosin. This liquid resin has good oxidative stability and is given a special steam-sparging treatment to assure minimum odor. With its low odor and low vapor pressure, Foralyn 5020-F CG is particularly useful as a fragrance fixative. It has excellent solubility and compatibility with non-polar and many polar ingredients in cosmetic applications, contributing both adhesion and gloss. Foralyn 5020-F Hydrogenated Rosin Esters Foralyn 5020-F hydrogenated rosin and rosin esters are a resin family based on stabilized rosin for adhesives and coatings. They are available with a softening point range from liquid to 11°C. The hydrogenation of Foralyn 5020-F improves its compatibility with adhesive base polymers, in contrast to non-hydrogenated rosin-resins, which results in improved adhesive performance. In particular Foralyn 5020-F hydrogenated rosin resins impart superior adhesion and excellent cohesion to adhesives based on styrenic block copolymers and acrylic polymers, especially at higher temperatures. Foralyn 5020-F Ester of Hydrogenated Rosin, the methyl ester of hydrogenated rosin, is a light amber liquid resin. Being hydrogenated, it has marked resistance to aging. To assure minimum odor of products in which it is used, it is given a special steam-sparging treatment. Foralyn 5020-F is used as a resinous plasticizer or tackifier in finished products such as adhesives, inks, and lacquers.
FORMALDEHYDE
formaldehyde; formalin; methanal; formol; Methyl aldehyde; Methylene oxide; Carbonyl hydride cas no: 50-00-0
FORMALDEHYDE 37 %
FORMALDEHYDE 37 % Properties Related Categories Aldehydes, Arbidol, Building Blocks, C1 to C6, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Chemicals for the synthesis of candidate COVID-19 treatments, Fixatives, Hematology and Histology, Organic Building Blocks Less... Quality Level 200 grade ACS reagent vapor density 1.03 (vs air) vapor pressure 52 mmHg ( 37 °C) 52 mmHg ( 37 °C) assay 36.5-38.0% autoignition temp. 572 °F Show More (23) Description General description Formaldehyde (formalin) is produced by oxidation of methanol. It is made of 37% formaldehyde and impurities such as methanol, small amounts of formic acid, aldehydes and ketones. It is used as a denaturant in formaldehyde-agarose gel electrophoresis of RNA.[1][2] Application Formaldehyde solution has been used as a fixing agent to fix cells during immunofluorescence imaging and for cross-linking cells during chromatin immunoprecipitation (ChIP) assay.[7] Formaldehyde solution has been used for cross-linking/fixing of cells in ChIP (chromatin immunoprecipitation) assay.[5][3] It has been used for fixing of cells for imaging.[6][4] Packaging 1, 4 L in glass bottle 25, 100, 4×100, 500, 6×500 mL in glass bottle Physical form This product is a solution of approximately 37% by weight of formaldehyde gas in water. Formaldehyde Formaldehyde (/fərˈmældəhaɪd/ (About this soundlisten) fer-mal-duh-hahyd, also /fɔːrˈmældəhaɪd/ (About this soundlisten) Formaldehitwr-) (systematic name methanal) is a naturally occurring organic compound with the formula CH2O (H−CHO). The pure compound is a pungent-smelling colourless gas that polymerises spontaneously into paraformaldehyde (refer to section Forms below), hence it is stored as an aqueous solution (formalin). It is the simplest of the aldehydes (R−CHO). The common name of this substance comes from its similarity and relation to formic acid. Formaldehyde is an important precursor to many other materials and chemical compounds. In 1996, the installed capacity for the production of formaldehyde was estimated at 8.7 million tons per year.[13] It is mainly used in the production of industrial resins, e.g., for particle board and coatings. In view of its widespread use, toxicity, and volatility, formaldehyde poses a significant danger to human health.[14][15] In 2011, the US National Toxicology Program described formaldehyde as "known to be a human carcinogen". Forms Formaldehyde is more complicated than many simple carbon compounds in that it adopts several diverse forms. These compounds can often be used interchangeably and can be interconverted. Molecular formaldehyde. A colorless gas with a characteristic pungent, irritating odor. It is stable at about 150 °C, but polymerizes when condensed to a liquid. 1,3,5-Trioxane, with the formula (CH2O)3. It is a white solid that dissolves without degradation in organic solvents. It is a trimer of molecular formaldehyde. Paraformaldehyde, with the formula HO(CH2O)nH. It is a white solid that is insoluble in most solvents. Methanediol, with the formula CH2(OH)2. This compound also exists in equilibrium with various oligomers (short polymers), depending on the concentration and temperature. A saturated water solution, of about 40% formaldehyde by volume or 37% by mass, is called "100% formalin". A small amount of stabilizer, such as methanol, is usually added to suppress oxidation and polymerization. A typical commercial grade formalin may contain 10–12% methanol in addition to various metallic impurities. "Formaldehyde" was first used as a generic trademark in 1893 following a previous trade name, "formalin".[19] Main forms of formaldehyde Monomeric formaldehyde (subject of this article). Trioxane is a stable cyclic trimer of formaldehyde. Paraformaldehyde is a common form of formaldehyde for industrial applications. Methanediol, the predominant species in dilute aqueous solutions of formaldehyde. Occurrence Processes in the upper atmosphere contribute up to 90% of the total formaldehyde in the environment. Formaldehyde is an intermediate in the oxidation (or combustion) of methane, as well as of other carbon compounds, e.g. in forest fires, automobile exhaust, and tobacco smoke. When produced in the atmosphere by the action of sunlight and oxygen on atmospheric methane and other hydrocarbons, it becomes part of smog. Formaldehyde has also been detected in outer space (see below). Formaldehyde and its adducts are ubiquitous in living organisms. It is formed in the metabolism of amino acids[which?] and is found in the bloodstream of humans and other primates at concentrations of approximately 0.1 millimolar.[20] Experiments in which animals are exposed to an atmosphere containing isotopically labeled formaldehyde have demonstrated that even in deliberately exposed animals, the majority of formaldehyde-DNA adducts found in non-respiratory tissues are derived from endogenously produced formaldehyde.[21] Formaldehyde does not accumulate in the environment, because it is broken down within a few hours by sunlight or by bacteria present in soil or water. Humans metabolize formaldehyde quickly, converting it to formic acid, so it does not accumulate in the body.[22] Interstellar formaldehyde Main article: Interstellar formaldehyde Formaldehyde appears to be a useful probe in astrochemistry due to prominence of the 110←111 and 211←212 K-doublet transitions. It was the first polyatomic organic molecule detected in the interstellar medium.[23] Since its initial detection in 1969, it has been observed in many regions of the galaxy. Because of the widespread interest in interstellar formaldehyde, it has been extensively studied, yielding new extragalactic sources.[24] A proposed mechanism for the formation is the hydrogenation of CO ice:[25] H + CO → HCO HCO + H → CH2O HCN, HNC, H2CO, and dust have also been observed inside the comae of comets C/2012 F6 (Lemmon) and C/2012 S1 (ISON).[26][27] Synthesis and industrial production Laboratory synthesis Formaldehyde was first reported in 1859 by the Russian chemist Aleksandr Butlerov (1828–86)[28] In his paper, Butlerov referred to formaldehyde as "dioxymethylen" (methylene dioxide) [page 247] because his empirical formula for it was incorrect (C4H4O4). It was conclusively identified by August Wilhelm von Hofmann, who first announced the production of formaldehyde by passing methanol vapor in air over hot platinum wire.[29][30] With modifications, Hoffmann's method remains the basis of the present day industrial route. Solution routes to formaldehyde also entail oxidation of methanol or methyl iodide.[31] Industry Formaldehyde is produced industrially by the catalytic oxidation of methanol. The most common catalysts are silver metal or a mixture of an iron and molybdenum or vanadium oxides. In the commonly used formox process, methanol and oxygen react at ca. 250–400 °C in presence of iron oxide in combination with molybdenum and/or vanadium to produce formaldehyde according to the chemical equation:[13] 2 CH3OH + O2 → 2 CH2O + 2 H2O The silver-based catalyst usually operates at a higher temperature, about 650 °C. Two chemical reactions on it simultaneously produce formaldehyde: that shown above and the dehydrogenation reaction: CH3OH → CH2O + H2 In principle, formaldehyde could be generated by oxidation of methane, but this route is not industrially viable because the methanol is more easily oxidized than methane.[13] Organic chemistry Formaldehyde is a building block in the synthesis of many other compounds of specialised and industrial significance. It exhibits most of the chemical properties of other aldehydes but is more reactive. Self-condensation and hydration Formaldehyde, unlike most aldehydes, oligomerizes spontaneously. The trimer is 1,3,5-trioxane, and the polymer is called paraformaldehyde. Many cyclic oligomers have been isolated. Similarly, formaldehyde hydrates to give the geminal diol methanediol, which condenses further to form oligomers HO(CH2O)nH. Monomeric CH2O is rarely encountered. Oxidation It is readily oxidized by atmospheric oxygen into formic acid. For this reason, commercial formaldehyde is typically contaminated with formic acid. Hydroxymethylation and chloromethylation Formaldehyde is a good electrophile. With good nucleophiles such as thiols, amines, and even amides, no acid catalyst is required. The resulting hydroxymethyl derivatives typically react further. Thus amines give hexahydro-1,3,5-triazines. Similarly, when combined with hydrogen sulfide, it forms trithiane.[32] 3 CH2O + 3 H2S → (CH2S)3 + 3 H2O In the presence of acids, it participates in electrophilic aromatic substitution reactions with aromatic compounds resulting in hydroxymethylated derivatives: ArH + CH2O → ArCH2OH When conducted in the presence of hydrogen chloride, the product is the chloromethyl compound, as described in the Blanc chloromethylation. If the arene is electron-rich, as in phenols, elaborate condensations ensue. With 4-substituted phenols one obtains calixarenes.[33] Phenol results in polymers. Base reactions Cannizzaro reaction in the presence of basic catalysts to produce formic acid and methanol. Uses Industrial applications Formaldehyde is a common precursor to more complex compounds and materials. In approximate order of decreasing consumption, products generated from formaldehyde include urea formaldehyde resin, melamine resin, phenol formaldehyde resin, polyoxymethylene plastics, 1,4-butanediol, and methylene diphenyl diisocyanate.[13] The textile industry uses formaldehyde-based resins as finishers to make Formaldehitbrics crease-resistant.[34] Formaldehyde-based materials are key to the manuFormaldehitcture of automobiles, and used to make components for the transmission, electrical system, engine block, door panels, axles and brake shoes. The value of sales of formaldehyde and derivative products was over $145 billion in 2003, about 1.2% of the gross domestic product (GDP) of the United States and Canada. Including indirect employment, over 4 million people work in the formaldehyde industry across approximately 11,900 plants in the U.S. and Canada.[35][permanent dead link] Two steps in formation of urea-formaldehyde resin, which is widely used in the production of particle board. When treated with phenol, urea, or melamine, formaldehyde produces, respectively, hard thermoset phenol formaldehyde resin, urea formaldehyde resin, and melamine resin. These polymers are common permanent adhesives used in plywood and carpeting. It is used as the wet-strength resin added to sanitary paper products such as (listed in increasing concentrations injected into the paper machine headstock chest) Formaldehitcial tissue, table napkins, and roll towels. They are also foamed to make insulation, or cast into moulded products. Production of formaldehyde resins accounts for more than half of formaldehyde consumption. Formaldehyde is also a precursor to polyfunctional alcohols such as pentaerythritol, which is used to make paints and explosives. Other formaldehyde derivatives include methylene diphenyl diisocyanate, an important component in polyurethane paints and foams, and hexamine, which is used in phenol-formaldehyde resins as well as the explosive RDX. Condensation with acetaldehyde affords pentaerythritol, a chemical necessary in synthesizing PETN, a high explosive.[36] Condensation with phenols gives phenol-formaldehyde resins. Niche uses Disinfectant and biocide An aqueous solution of formaldehyde can be useful as a disinfectant as it kills most bacteria and fungi (including their spores). It is used as an additive in vaccine manuFormaldehitcturing to inactivate toxins and pathogens.[37] Formaldehyde releasers are used as biocides in personal care products such as cosmetics. Although present at levels not normally considered harmful, they are known to cause allergic contact dermatitis in certain sensitised individuals.[38] Aquarists use formaldehyde as a treatment for the parasites Ichthyophthirius multifiliis and Cryptocaryon irritans.[39] Formaldehyde is also approved for use in the manuFormaldehitcture of animal feeds in the US. It is an antimicrobial agent used to maintain complete animal feeds or feed ingredients Salmonella negative for up to 21 days.[40] Tissue fixative and embalming agent Injecting a giant squid specimen with formalin for preservation. Formaldehyde preserves or fixes tissue or cells. The process involves cross-linking of primary amino groups. The European Union has banned the use of formaldehyde as a biocide (including embalming) under the Biocidal Products Directive (98/8/EC) due to its carcinogenic properties.[41][42] Countries with a strong tradition of embalming corpses, such as Ireland and other colder-weather countries, have raised concerns. Despite reports to the contrary,[43] no decision on the inclusion of formaldehyde on Annex I of the Biocidal Products Directive for product-type 22 (embalming and taxidermist fluids) had been made as of September 2009.[44] Formaldehyde-based crosslinking is exploited in ChIP-on-chip or ChIP-sequencing genomics experiments, where DNA-binding proteins are cross-linked to their cognate binding sites on the chromosome and analyzed to determine what genes are regulated by the proteins. Formaldehyde is also used as a denaturing agent in RNA gel electrophoresis, preventing RNA from forming secondary structures. A solution of 4% formaldehyde fixes pathology tissue specimens at about one mm per hour at room temperature. Drug testing Formaldehyde and an 18 M (concentrated) sulfuric acid makes Marquis reagent—which can identify alkaloids and other compounds. Photography In photography, formaldehyde is used in low concentrations for process C-41 (color negative film) stabilizer in the final wash step,[45] as well as in the process E-6 pre-bleach step, to make it unnecessary in the final wash. Safety Formaldehyde occurs naturally, and is "an essential intermediate in cellular metabolism in mammals and humans."[13] Ingestion of as little as 30 milliliters (1 oz.) of a 37% solution of formaldehyde has been reported to cause death in an adult.[46] Other concerns are associated with chronic (long term) exposure by inhalation. This may happen from three main sources: thermal or chemical decomposition of formaldehyde-based resins, emission from aqueous formaldehyde solutions (e.g. embalming fluids), and the production of formaldehyde resulting from the combustion of a variety of organic compounds (for example, exhaust gases). As formaldehyde resins are used in many construction materials it is one of the more common indoor air pollutants.[47] At concentrations above 0.1 ppm in air formaldehyde can irritate the eyes and mucous membranes, resulting in watery eyes.[48] Formaldehyde inhaled at this concentration may cause headaches, a burning sensation in the throat, and difficulty breathing, and can trigger or aggravate asthma symptoms.[49][50] A 1988 Canadian study of houses with urea-formaldehyde foam insulation found that formaldehyde levels as low as 0.046 ppm were positively correlated with eye and nasal irritation.[51] A 2009 review of studies has shown a strong association between exposure to formaldehyde and the development of childhood asthma.[52] The primary exposure concern is for the workers in the industries producing or using formaldehyde. A theory was proposed for the carcinogenesis of formaldehyde in 1978.[53] In 1987 the U.S. EPA classified it as a probable human carcinogen, and after more studies the WHO International Agency for Research on Cancer (IARC) in 1995 also classified it as a probable human carcinogen. Further information and evaluation of all known data led the IARC to reclassify formaldehyde as a known human carcinogen[54] associated with nasal sinus cancer and nasopharyngeal cancer.[55] 2009 and 2010 studies have also shown a positive correlation between exposure to formaldehyde and the development of leukemia, particularly myeloid leukemia.[56][57] Nasopharyngeal and sinonasal cancers are relatively rare, with a combined annual incidence in the United States of < 4,000 cases.[58][59] About 30,000 cases of myeloid leukemia occur in the United States each year.[60][61] Some evidence suggests that workplace exposure to formaldehyde contributes to sinonasal cancers.[62] Professionals exposed to formaldehyde in their occupation, such as funeral industry workers and embalmers, showed an increased risk of leukemia and brain cancer compared with the general population.[63] Other Formaldehitctors are important in determining individual risk for the development of leukemia or nasopharyngeal cancer.[62][64][65] In the residential environment, formaldehyde exposure comes from a number of routes; formaldehyde can emitted by treated wood products, such as plywood or particle board, but it is produced by paints, varnishes, floor finishes, and cigarette smoking as well.[66] In July 2016, the U.S. EPA released a prepublication version of its final rule on Formaldehyde Emission Standards for Composite Wood Products.[67] These new rules impact manuFormaldehitcturers, importers, distributors, and retailers of products containing composite wood, including fiberboard, particleboard, and various laminated products, who must comply with more stringent record-keeping and labeling requirements.[68] The United States Environmental Protection Agency (EPA) allows no more than 0.016 ppm formaldehyde in the air in new buildings constructed for that agency.[69][Formaldehitiled verification] A U.S. Environmental Protection Agency study found a new home measured 0.076 ppm when brand new and 0.045 ppm after 30 days.[70] The Federal Emergency Management Agency (FEMA) has also announced limits on the formaldehyde levels in trailers purchased by that agency.[71] The EPA recommends the use of "exterior-grade" pressed-wood products with phenol instead of urea resin to limit formaldehyde exposure, since pressed-wood products containing formaldehyde resins are often a significant source of formaldehyde in homes.[55] Patch test For most people, irritation from formaldehyde is temporary and reversible, although formaldehyde can cause allergies and is part of the standard patch test series. In 2005–06, it was the seventh-most-prevalent allergen in patch tests (9.0%).[72] People with formaldehyde allergy are advised to avoid formaldehyde releasers as well (e.g., Quaternium-15, imidazolidinyl urea, and diazolidinyl urea).[73] People who suffer allergic reactions to formaldehyde tend to display lesions on the skin in the areas that have had direct contact with the substance, such as the neck or thighs (often due to formaldehyde released from permanent press finished clothing) or dermatitis on the Formaldehitce (typically from cosmetics).[38] Formaldehyde has been banned in cosmetics in both Sweden[citation needed] and Japan.[74] The eyes are most sensitive to formaldehyde exposure: The lowest level at which many people can begin to smell formaldehyde ranges between 0.05-1 ppm. The maximum concentration value at the workplace is 0.3 ppm.[75][need quotation to verify] In controlled chamber studies, individuals begin to sense eye irritation at about 0.5 ppm; 5 to 20 percent report eye irritation at 0.5 to 1 ppm; and greater certainty for sensory irritation occurred at 1 ppm and above. While some agencies have used a level as low as 0.1 ppm as a threshold for irritation, the expert panel found that a level of 0.3 ppm would protect against nearly all irritation. In Formaldehitct, the expert panel found that a level of 1.0 ppm would avoid eye irritation—the most sensitive endpoint—in 75–95% of all people exposed.[76] Formaldehyde levels in building environments are affected by a number of Formaldehitctors. These include the potency of formaldehyde-emitting products present, the ratio of the surFormaldehitce area of emitting materials to volume of space, environmental Formaldehitctors, product age, interactions with other materials, and ventilation condition. Formaldehyde emits from a variety of construction materials, furnishings, and consumer products. The three products that emit the highest concentrations are medium density fiberboard, hardwood plywood, and particle board. Environmental Formaldehitctors such as temperature and relative humidity can elevate levels because formaldehyde has a high vapor pressure. Formaldehyde levels from building materials are the highest when a building first opens because materials would have less time to off-gas. Formaldehyde levels decrease over time as the sources suppress. Formaldehyde levels in air can be sampled and tested in several ways, including impinger, treated sorbent, and passive monitors.[77] The National Institute for Occupational Safety and Health (NIOSH) has measurement methods numbered 2016, 2541, 3500, and 3800.[78] Studies on the interactions between formaldehyde and proteins at the molecular level have been reported on the effects of the body's carrier protein, serum albumin. The binding of formaldehyde loosens the skeletal structure of albumin and causes exposure of aromatic ring amino acids in the internal hydrophobic region. Symptoms may affect personal awareness, making one feel tired or Formaldehittigued.[citation needed] Formaldehyde inhalation has also shown to cause oxidative stress and inflammation in animals. Mice studied over an exposure to a high dose of formaldehyde (3ppm), showed increased NO− 3 levels in plasma. This result suggests that Formaldehit inhalation either decreased NO production or increased NO scavenging, which may be an anti-stress mechanism in the body. Formaldehyde inhalation changes the sensitivity of immune system, which influences oxidative stress.[citation needed] In June 2011, the twelfth edition of the National Toxicology Program (NTP) Report on Carcinogens (RoC) changed the listing status of formaldehyde from "reasonably anticipated to be a human carcinogen" to "known to be a human carcinogen."[16][17][18] Concurrently, a National Academy of Sciences (NAS) committee was convened and issued an independent review of the draft United States Environmental Protection Agency IRIS assessment of formaldehyde, providing a comprehensive health effects assessment and quantitative estimates of human risks of adverse effects.[79] International bans Several web articles claim that formaldehyde has been banned from manuFormaldehitcture or import into the European Union (EU) under REACH (Registration, Evaluation, Authorization, and restriction of Chemical substances) legislation. That is a misconception, as formaldehyde is not listed in the Annex I of Regulation (EC) No 689/2008 (export and import of dangerous chemicals regulation), nor on a priority list for risk assessment. However, formaldehyde is banned from use in certain applications (preservatives for liquid-cooling and processing systems, slimicides, metalworking-fluid preservatives, and antifouling products) under the Biocidal Products Directive.[80][81] In the EU, the maximum allowed concentration of formaldehyde in finished products is 0.2%, and any product that exceeds 0.05% has to include a warning that the product contains formaldehyde.[38] In the United States, Congress passed a bill July 7, 2010 regarding the use of formaldehyde in hardwood plywood, particle board, and medium density fiberboard. The bill limited the allowable amount of formaldehyde emissions from these wood products to .09 ppm, and required companies to meet this standard by January 2013.[82] The final Environmental Protection Agency rule specified maximum emissions of "0.05 ppm formaldehyde for hardwood plywood, 0.09 ppm formaldehyde for particleboard, 0.11 ppm formaldehyde for medium-density fiberboard, and 0.13 ppm formaldehyde for thin medium-density fiberboard."[83] Formaldehyde was declared a toxic substance by the 1999 Canadian Environmental Protection Act.[84] External media Fema trailer 1 Mariel Carr Chemical Heritage Foundation Video.jpg Audio audio icon "Episode 202: Where Have All the FEMA Trailers Gone? Tracing Toxicity from Bust to Boom", Distillations, September 2, 2015, Science History Institute Video video icon Where Have All the Trailers Gone?, Video by Mariel Carr (Videographer) & Nick Shapiro (Researcher), 2015, Science History Institute Contaminant in food Scandals have broken in both the 2005 Indonesia food scare and 2007 Vietnam food scare regarding the addition of formaldehyde to foods to extend shelf life. In 2011, after a four-year absence, Indonesian authorities found foods with formaldehyde being sold in markets in a number of regions across the country.[85] In August 2011, at least at two Carrefour supermarkets, the Central Jakarta Livestock and Fishery Sub-Department found a sweet glutinous rice drink (cendol) contained 10 parts per million of formaldehyde.[86] In 2014, the owner of two noodle Formaldehitctories in Bogor, Indonesia, was arrested for using formaldehyde in noodles. 50 kg of formaldehyde was confiscated.[87] Foods known to be contaminated included noodles, salted fish, and tofu. Chicken and beer were also rumored to be contaminated. In some places, such as China, manuFormaldehitcturers still use formaldehyde illegally as a preservative in foods, which exposes people to formaldehyde ingestion.[88] In humans, the ingestion of formaldehyde has been shown to cause vomiting, abdominal pain, dizziness, and in extreme cases can cause death. Testing for formaldehyde is by blood and/or urine by gas chromatography-mass spectrometry. Other methods include infrared detection, gas detector tubes, etc., of which high-performance liquid chromatography is the most sensitive.[89] In the early 1900s, it was frequently added by US milk plants to milk bottles as a method of pasteurization due to the lack of knowledge and concern[90] regarding formaldehyde's toxicity.[91][92] In 2011 in Nakhon Ratchasima, Thailand, truckloads of rotten chicken were treated with formaldehyde for sale in which "a large network," including 11 slaughterhouses run by a criminal gang, were implicated.[93] In 2012, 1 billion rupiah (almost US$100,000) of fish imported from Pakistan to Batam, Indonesia, were found laced with formaldehyde.[94] Formalin contamination of foods has been reported in Bangladesh, with stores and supermarkets selling fruits, fishes, and vegetables that have been treated with formalin to keep them fresh.[95] However, in 2015, a Formalin Control Bill was passed in the Parliament of Bangladesh with a provision of life-term imprisonment as the maximum punishment and in addition 2,000,000 BDT as fine but not less than 500,000 BDT for importing, production or hoarding of formalin without license Formaldehyde What is formaldehyde? Formaldehyde is a colorless, strong-smelling gas used in making building materials and many household products. It is used in pressed-wood products, such as particleboard, plywood, and fiberboard; glues and adhesives; permanent-press Formaldehitbrics; paper product coatings; and certain insulation materials. It is also used to make other chemicals. Formaldehyde is quickly broken down in the air – generally within hours. It dissolves easily in water, but does not last long there, either. When dissolved in water it is called formalin, which is commonly used as an industrial disinfectant, and as a preservative in funeral homes and medical labs. It can also be used as a preservative in some foods and in products, such as antiseptics, medicines, and cosmetics. Sometimes, although formaldehyde is not used, substances that release formaldehyde are. These have been found in cosmetics, soaps, shampoos, lotions and sunscreens, and cleaning products. Formaldehyde can be added as a preservative to food, but it can also be produced as the result of cooking and smoking. Formaldehyde also occurs naturally in the environment. Humans and most other living organisms make small amounts as part of normal metabolic processes. How are people exposed to formaldehyde? The main way people are exposed to formaldehyde is by inhaling it. The liquid form can be absorbed through the skin. People can also be exposed to small amounts by eating foods or drinking liquids containing formaldehyde. Formaldehyde is normally made in the body. Enzymes in the body break down formaldehyde into formate (formic acid), which can be further broken down into carbon dioxide. Most inhaled formaldehyde is broken down by the cells lining the mouth, nose, throat, and airways, so that less than a third is absorbed into the blood. According to the US Consumer Product Safety Commission, formaldehyde is normally present at low levels (less than 0.03 parts per million) in both indoor and outdoor air. Materials containing formaldehyde can release it as a gas or vapor into the air. Automobile exhaust is a major source of formaldehyde in outdoor air. During the 1970s, urea-formaldehyde foam insulation (UFFI) was used in many homes. But few homes are now insulated with UFFI. Homes in which UFFI was installed many years ago are not likely to have high formaldehyde levels now. Pressed-wood products containing formaldehyde resins are often a source of formaldehyde in homes. Using unvented fuel-burning appliances, such as gas stoves, wood-burning stoves, and kerosene heaters can also raise formaldehyde levels indoors. Formaldehyde is also a component of tobacco smoke and both smokers and those breathing secondhand smoke are exposed to higher levels of formaldehyde. One study found much higher levels of formaldehyde bound to DNA in the white blood cells of smokers compared to non-smokers. Formaldehyde and other chemicals that release formaldehyde are sometimes used in low concentrations in cosmetics and other personal care products like lotions, shampoo, conditioner, shower gel, and some fingernail polishes. These may raise the concentration of formaldehyde in the air inside the room for a short time, but the levels reached are Formaldehitr below what is considered to be hazardous. Professional keratin hair smoothing treatments can contain formaldehyde or formaldehyde releasing chemicals. Using these can raise indoor air concentrations of formaldehyde to levels that could be a potential hazard. Workers in industries that make formaldehyde or formaldehyde-containing products, lab technicians, some health care professionals, and funeral home employees may be exposed to higher levels of formaldehyde than the general public. Exposure occurs mainly by inhaling formaldehyde gas or vapor from the air or by absorbing liquids containing formaldehyde through the skin. In one large study of workers in industries that make or use formaldehyde, the average level of formaldehyde exposure was 0.45 parts per million (ppm) overall, with less than 3% of workers experiencing more than 2 ppm on average. Can formaldehyde cause cancer? Exposure to formaldehyde has been shown to cause cancer in laboratory test animals. Exposure to relatively high amounts of formaldehyde in medical and occupational settings has been linked to some types of cancer in humans, but the effect of exposure to small amounts is less clear. Studies in the lab In rats, inhaled formaldehyde was linked to cancers of the nasal cavity and leukemia. In one study of rats given drinking water containing formaldehyde there was an increase in stomach tumors, while another showed no increase in any kind of tumor or cancer. In mice, applying a 10% solution of formaldehyde to the skin was linked to quicker development of cancers caused by another chemical. Studies in people In one study, inhaling formaldehyde at levels at a concentration of 1.9 parts per million (ppm) for 40 minutes did not increase blood levels of formaldehyde. Several epidemiology studies of people exposed to formaldehyde in the workplace have reported a link between formaldehyde exposure and cancer of the nasopharynx (the uppermost part of the throat), but this outcome has not been observed in other studies. These studies looked at workers in occupational setting that use or make formaldehyde and formaldehyde resins, as well as at people who work as embalmers. Studies of people exposed to formaldehyde in the workplace have also found a possible link to cancer of the nasal sinuses.
FORMALDEHYDE SODIUM SULFOXYLATE (RONGALIT C)
Hydrogencarboxylic acid; aminic acid; formylic acid; Formic acid; Methanoic acid; Acide Formique (French); Acido Formico (Italian); Ameisensaeure (German); Kwas Metaniowy (Polish); Kyselina Mravenci (Czech); Ameisensäure; Mierenzuur (Dutch); ácido fórmico (Spanish); Acide Formique (French); Other RN: 8006-93-7, 82069-14-5 cas no: 64-18-6
FORMIC ACID
EC / List no.: 200-579-1
CAS no.: 64-18-6
Mol. formula: CH2O2

Formic acid (HCO2H), also called methanoic acid, the simplest of the carboxylic acids, used in processing textiles and leather.
Formic acid was first isolated from certain ants and was named after the Latin formica, meaning “ant.”
Formic Acid is made by the action of sulfuric acid upon sodium formate, which is produced from carbon monoxide and sodium hydroxide.
Formic acid is also prepared in the form of Formic acids esters by treatment of carbon monoxide with an alcohol such as methanol (methyl alcohol) in the presence of a catalyst.

Formic acid, systematically named methanoic acid, is the simplest carboxylic acid, and has the chemical formula H2CO2.
Formic acid is an important intermediate in chemical synthesis and occurs naturally, most notably in some ants.
The word "formic" comes from the Latin word for ant, formica, referring to Formic acids early isolation by the distillation of ant bodies.
Esters, salts, and the anion derived from formic acid are called formates.
Industrially, formic acid is produced from methanol.

Uses
Preservative of silage; reducer in dyeing wool; lime descaler; pH adjustor in cosmetic products.
Formic acid has a number of commercial uses.
Formic acid is used in the leather industry to degreaseand remove hair from hides and as an ingredient in tanning formulations.
Formic acid is used as alatex coagulant in natural rubber production.
Formic acid and its formulations are used aspreservatives of silage.

Formic acid is especially valued in Europe where laws require the use of naturalantibacterial agents rather than synthetic antibiotics.
Silage is fermented grass and crops thatare stored in silos and used for winter feed.
Silage is produced during anaerobic fermentationwhen bacteria produce acids that lower the pH, preventing further bacterial action.
Acetic acidand lactic acid are the desired acids during silage fermentation.
Formic acid is used in silageprocessing to reduce undesirable bacteria and mold growth.
Formic acid reduces Clostridiabacteria that would produce butyric acid causing spoilage.

In addition to preventing silagespoilage, formic acid helps preserve protein content, improves compaction, and preservessugar content.
Formic acid is used as a miticide by beekeepers.
Formic acid occurs in the stings of ants andbees.
Formic acid is used in the manufacture of estersand salts, dyeing and finishing of textiles andpapers, electroplating, treatment of leather,and coagulating rubber latex, and also as areducing agent.
Formic Acid is a flavoring substance that is liquid and colorless, and possesses a pungent odor.
Formic Acid is miscible in water, alcohol, ether, and glycerin, and is obtained by chemical synthesis or oxidation of methanol or formaldehyde.

Properties
Formic acid is a colorless liquid having a pungent, penetrating odor at room temperature, comparable to the related acetic acid.
Formic acid is miscible with water and most polar organic solvents, and is somewhat soluble in hydrocarbons.
In hydrocarbons and in the vapor phase, Formic acid consists of hydrogen-bonded dimers rather than individual molecules.
Owing to its tendency to hydrogen-bond, gaseous formic acid does not obey the ideal gas law.
Solid formic acid, which can exist in either of two polymorphs, consists of an effectively endless network of hydrogen-bonded formic acid molecules.
Formic acid forms a high-boiling azeotrope with water (22.4%).
Liquid formic acid tends to supercool.

Formic acid is a reagent used for formylation, hydrolysis, and cyclocondensations.
Formic Acid has also been used in the dyeing of natural and synthetic fibers, feed and fodder preservation, leather tanning, the production of commercial cleaning products and in rubber coagulation.
In organic synthesis, Formic acid has been used in the synthesis of such classes of compounds as coumarins, optically active styrene oxides, and polyamide oligomers based on 14-amino - 3,6,9,12 - tetraoxatetradecanoic acid.
Formic Acid can be used in the mobile phase for various LC-MS analytical methods, such as an LC-MS study of spiroketal stereoisomers of pectenotoxins and an LC/ESI-MS/UV photodiode arrary method for the analysis of flavonoid glycosides.
A method to measure internal nucleoside triphosphate pools of lactococci that uses formic acid in the chromatographic separation has been described.
The use of formic acid in the separation and detection of intact proteins by reversed-phase LC/ESI-MS by flow injection analysis has been reported.

A major use of formic acid is as a preservative and antibacterial agent in livestock feed.
Formic Acid is also significantly used in the production of leather, including tanning, and in dyeing and finishing textiles.

USES AND APPLICATIONS FOR FORMIC ACID
INDUSTRIES
-Pharma
-Lubricants
-Water Treatment
-Oil & Gas
-Cleaning
-Animal Nutrition
-Coatings & Construction
-Food and Nutrition
-Agriculture
-Cosmetics
-Solvents
-Polymers
-Rubber

Formic acid Uses
A major use of formic acid is as a preservative and antibacterial agent in livestock feed.
In Europe, Formic acid is applied on silage, including fresh hay, to promote the fermentation of lactic acid and to suppress the formation of butyric acid; it also allows fermentation to occur quickly, and at a lower temperature, reducing the loss of nutritional value.
Formic acid arrests certain decay processes and causes the feed to retain its nutritive value longer, and so Formic acid is widely used to preserve winter feed for cattle.
In the poultry industry, Formic acid is sometimes added to feed to kill E. coli bacteria.
Use as a preservative for silage and (other) animal feed constituted 30% of the global consumption in 2009.

Formic acid is also significantly used in the production of leather, including tanning (23% of the global consumption in 2009), and in dyeing and finishing textiles (9% of the global consumption in 2009) because of its acidic nature.
Use as a coagulant in the production of rubber consumed 6% of the global production in 2009.

Formic acid is also used in place of mineral acids for various cleaning products, such as limescale remover and toilet bowl cleaner.
Some formate esters are artificial flavorings and perfumes.

Beekeepers use formic acid as a miticide against the tracheal mite (Acarapis woodi) and the Varroa destructor mite and Varroa jacobsoni mite.
Formic acid application has been reported to be an effective treatment for warts.
Formic acid can be used in a fuel cell (it can be used directly in formic acid fuel cells and indirectly in hydrogen fuel cells).
Formic acid is possible to use formic acid as an intermediary to produce isobutanol from CO2 using microbes
Formic acid has a potential application in soldering, due to Formic acids capacity to reduce oxide layers, formic acid gas can be blasted at an oxide surface in order to increase solder wettability.

Chemical reactions
Formic acid is about ten times stronger than acetic acid.
Formic acid is used as a volatile pH modifier in HPLC and capillary electrophoresis.

Formic acid is a source for a formyl group for example in the formylation of methylaniline to N-methylformanilide in toluene.
In synthetic organic chemistry, formic acid is often used as a source of hydride ion.
The Eschweiler-Clarke reaction and the Leuckart-Wallach reaction are examples of this application.
Formic acid, or more commonly Formic acids azeotrope with triethylamine, is also used as a source of hydrogen in transfer hydrogenation.
As mentioned below, formic acid readily decomposes with concentrated sulfuric acid to form carbon monoxide.
CH2O2 + H2SO4 → H2SO4 + H2O + CO

Reactions
Formic acid shares most of the chemical properties of other carboxylic acids. Because of Formic acids high acidity, solutions in alcohols form esters spontaneously.
Formic acid shares some of the reducing properties of aldehydes, reducing solutions of metal oxides to their respective metal.

Decomposition
Heat and especially acids cause formic acid to decompose to carbon monoxide (CO) and water (dehydration).
Treatment of formic acid with sulfuric acid is a convenient laboratory source of CO.
In the presence of platinum, Formic acid decomposes with a release of hydrogen and carbon dioxide.

CH2O2 → H2 + CO2
Soluble ruthenium catalysts are also effective.
Carbon monoxide free hydrogen has been generated in a very wide pressure range (1–600 bar).
Formic acid has been considered as a means of hydrogen storage.
The co-product of this decomposition, carbon dioxide, can be rehydrogenated back to formic acid in a second step.
Formic acid contains 53 g/L hydrogen at room temperature and atmospheric pressure, which is three and a half times as much as compressed hydrogen gas can attain at 350 bar pressure (14.7 g/L).
Pure formic acid is a liquid with a flash point of +69 °C, much higher than that of gasoline (−40 °C) or ethanol (+13 °C).

Addition to alkenes
Formic acid is unique among the carboxylic acids in Formic acids ability to participate in addition reactions with alkenes.
Formic acids and alkenes readily react to form formate esters.
In the presence of certain acids, including sulfuric and hydrofluoric acids, however, a variant of the Koch reaction occurs instead, and formic acid adds to the alkene to produce a larger carboxylic acid.

Formic acid anhydride
An unstable formic anhydride, H(C=O)−O−(C=O)H, can be obtained by dehydration of formic acid with N,N′-dicyclohexylcarbodiimide in ether at low temperature.

Formic acid History
Some alchemists and naturalists were aware that ant hills give off an acidic vapor as early as the 15th century.
The first person to describe the isolation of Formic acid (by the distillation of large numbers of ants) was the English naturalist John Ray, in 1671.
Ants secrete the formic acid for attack and defense purposes.
Formic acid was first synthesized from hydrocyanic acid by the French chemist Joseph Gay-Lussac.
In 1855, another French chemist, Marcellin Berthelot, developed a synthesis from carbon monoxide similar to the process used today.

Formic acid was long considered a chemical compound of only minor interest in the chemical industry.
In the late 1960s, however, significant quantities became available as a byproduct of acetic acid production.
Formic acid now finds increasing use as a preservative and antibacterial in livestock feed.

Formic Acid is a reagent comprised of the organic chemical formic acid that cleaves proteins into peptides at the C- or N-terminal side of an aspartate residue.

Formic acid appears as a colorless liquid with a pungent odor.
Flash point 156°F.
Density 10.2 lb / gal.
Corrosive to metals and tissue.

Formic acid is the simplest carboxylic acid, containing a single carbon.
Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent.
Principally used as a preservative and antibacterial agent in livestock feed.
Induces severe metabolic acidosis and ocular injury in human subjects.
Formic acid has a role as an antibacterial agent, a protic solvent, a metabolite, a solvent and an astringent.
Formic acid is a conjugate acid of a formate.

Uses at Household & Commercial/Institutional Products
• Auto Products
• Home Maintenance
• Inside the Home
• Personal Care

Uses of Formic Acid
Both oil base and water base fracturing fluids are being used in the fracturing industry.
Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids.
The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, surfactants, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer.

Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground.
These cracks in the rock then allow oil and natural gas to flow, increasing resource production.
Chemical Name: Formic acid; Chemical Purpose: Prevents the corrosion of the pipe; Product Function: Corrosion inhibitor.

Industry Uses of Formic acid
-Adhesives and sealant chemicals
-Agricultural chemicals (non-pesticidal)
-Bleaching agents
-Corrosion inhibitors and anti-scaling agents
-Intermediates
-Paint additives and coating additives not described by other categories
-Plating agents and surface treating agents
-Preservative
-Process regulators
-Processing aids, not otherwise listed
-Processing aids, specific to petroleum production
-Solids separation agents
-Solvents (which become part of product formulation or mixture)
-Surface active agents

Consumer Uses of Formic acid
-Agricultural products (non-pesticidal)
-Apparel and footwear care products
-Automotive care products
-Building/construction materials - wood and engineered wood products
-Electrical and electronic products
-Explosive materials
-Fabric, textile, and leather products not covered elsewhere
-Fuels and related products
-Laundry and dishwashing products
-Metal products not covered elsewhere
-Non-TSCA use
-Paper products
-Personal care products
-Plastic and rubber products not covered elsewhere
-Water treatment products
-industrial
-urethane intermediate

Methods of Manufacturing
Synthesis of formic acid by hydrolysis of methyl formate is based on a two-stage process: in the first stage, methanol is carbonylated with carbon monoxide; in the second stage, methyl formate is hydrolyzed to formic acid and methanol.

Formic acid is produced as a byproduct in the liquid-phase oxidation of hydrocarbons to acetic acid.
In the United States, butane is used as the hydrocarbon, and ca. 50 kg of formic acid is produced per ton of acetic acid.
In Europe, the oxidation of naphtha is preferred, and up to 250 kg of formic acid is produced per ton of acetic acid in this process.

The reaction of sodium formate or calcium formate with strong mineral acids, such as sulfuric and nitric acids, is the oldest known process for producing formic acid commercially.
If formates or sodium hydroxide are available cheaply or occur as byproducts in other processes, formic acid can still be produced economically in this manner.

General Manufacturing Information
Industry Processing Sectors
-Agriculture, forestry, fishing and hunting
-All other basic organic chemical manufacturing
-All other chemical product and preparation manufacturing
-Computer and electronic product manufacturing
-Construction
-Electrical equipment, appliance, and component manufacturing
-Fabricated metal product manufacturing
-Food, beverage, and tobacco product manufacturing
-Mining (except oil and gas) and support activities
-Miscellaneous manufacturing
-Oil and gas drilling, extraction, and support activities
-Paint and coating manufacturing
-Paper manufacturing
-Pesticide, fertilizer, and other agricultural chemical manufacturing
-Pharmaceutical and medicine manufacturing
-Plastic material and resin manufacturing
-Soap, cleaning compound, and toilet preparation manufacturing
-Textiles, apparel, and leather manufacturing
-Utilities
-Wholesale and retail trade
-Wood product manufacturing
-resale of chemicals

About Formic acid
Helpful information
Formic acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

Formic acid is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Biocidal Uses
Formic acid is being reviewed for use as a biocide in the EEA and/or Switzerland, for: disinfection, veterinary hygiene, food and animals feeds, drinking water, product preservation.

Consumer Uses
Formic acid is used in the following products: washing & cleaning products, leather treatment products, polymers, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products), coating products, metal surface treatment products, pH regulators and water treatment products and plant protection products. Other release to the environment of Formic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

Article service life
ECHA has no public registered data on the routes by which Formic acid is most likely to be released to the environment.
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
Formic acid is used in the following products: laboratory chemicals and pH regulators and water treatment products.
Formic acid is used in the following areas: scientific research and development and health services.
Other release to the environment of Formic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

Formulation or re-packing
Formic acid is used in the following products: laboratory chemicals.
Release to the environment of Formic acid can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, in the production of articles and as processing aid.

Uses at industrial sites
Formic acid is used in the following products: polymers.
Formic acid is used in the following areas: formulation of mixtures and/or re-packaging.
Formic acid is used for the manufacture of: chemicals, textile, leather or fur and plastic products.
Release to the environment of Formic acid can occur from industrial use: in processing aids at industrial sites, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, in the production of articles, as processing aid and formulation of mixtures.

Manufacture
Release to the environment of Formic acid can occur from industrial use: manufacturing of the substance.

General Description
Formic acid (HCO2H), also called methanoic acid, is the simplest carboxylic acid.
Formic acid was first isolated by the distillation of ant bodies and was named after the Latin formica, meaning “ant.”
Formic acids proper IUPAC name is now methanoic acid. Industrially, formic acid is produced by treatment of carbon monoxide with an alcohol such as methanol (methyl alcohol) in the presence of a catalyst.
Formic acid is found both naturally occurring and frequently synthesized in laboratories.
Formic acid is most naturally found in the stings and bites of many insects, including bees and ants, as a chemical defense mechanism.

Properties
FORMIC ACID is a colorless liquid with a pungent odor.
Formic acid is a stable corrosive, combustible, and hygroscopic chemical substance.
Formic acid is incompatible with H2SO4, strong caustics, furfuryl alcohol, hydrogen peroxide, strong oxidisers, and bases and reacts with strong explosion on contact with oxidising agents.
Due to the −CHO group, Formic acid imparts some of the character of an aldehyde.

Formic acid can form salt and ester; can react with amine to form amide and to form ester by addition reaction with unsaturated hydrocarbon addition.
Formic acid can reduce the silver ammonia solution to produce a silver mirror, and make the potassium permanganate solution fade, which can be used for the qualitative identification of formic acid.
As a carboxylic acid, formic acid shares most of the same chemical properties in reacting with alkalis to form water soluble formate.
But formic acid is not a typical carboxylic acid as Formic acid can react with alkenes to form formate esters.

Production
Since 1896, Formic acid is made in European countries by the action of sulfuric acid upon sodium formate, which is produced from carbon monoxide and sodium hydroxide.
In 1980, the United States Science and Design Corporation developed a carbonylation of methanol to produce formic acid with an annual output of 20,000 tons.

The reaction formula is:
The mixture of liquid ammonia and methanol is used to absorb carbon monoxide at 70 ° C and 32.5 MPa to form formamide, which is then hydrolyzed in an aqueous acid solution.
Use oxalic acid and glycerol as raw materials being co-heated at 110 ° C to generate oxalic acid monoglyceride.
Heat it to decarboxylate and form Monoglycerides formate, then hydrolyze it to obtain formic acid.
After the formic acid aqueous solution is obtained, a dehydrating agent (for anhydrous magnesium sulfate, anhydrous copper sulfate, etc.), extractive distillation (extracting agent may be trimethylamine, picoline, etc.) may be used for dehydration and purification, and anhydrous formic aic can be obtained.

Description
Formic acid is a clear, colorless liquid with a pungent odor.
Formic acid was first isolated from certain ants and was named after the Latin formica, meaning ant.
Formic acid is made by the action of sulfuric acid on sodium formate, which is produced from carbon monoxide and sodium hydroxide.
Formic acid is also produced as a by-product in the manufacture of other chemicals such as acetic acid.
Formic acid can be anticipated that use of formic acid will continuously increase as Formic acid replaces inorganic acids and has a potential role in new energy technology.
Formic acid toxicity is of a special interest as the acid is the toxic metabolite of methanol.

Chemical Properties
Formic acid, or methanoic acid, is the first member of the homologous series identified as fatty acids with the general formula RCOOH.
Formic acid was obtained first from the red ant; Formic acids common name is derived from the family name for ants, Formi- cidae.
This substance also occurs naturally in bees and wasps, and is presumed to be responsible for the "sting" of these insects.
Formic acid has a pungent, penetrating odor.
Formic acid may be synthesized from anhydrous sodium formate and concentrated H2S04 at low temperature followed by distillation.

Formic acid has a pungent, penetrating odor Formic acid is the first member of the homologous series identifed as fatty acids with general formula RCOOH This acid was obtained frst from the red ants; its common name is derived from the family name for ants, Formicidae.
Formic acid also occurs naturally in bees and wasps and is presumed to be responsible for the sting of these insects.

Occurrence
Widespread in a large variety of plants; reported identifed in Cistus labdanum and the oil of Artemisia trans- iliensis; also found among the constituents of petit grain lemon and bitter orange essential oil; reported found in strawberry aroma Reported found in apple, sweet cherry, papaya, pear, raspberry, strawberry, peas, cheeses, breads, yogurt, milk, cream, buttermilk, raw fsh, cognac, rum, whiskey, cider, white wine, tea, coffee and roasted chicory root

Formic acid is manufactured as a by-product of the liquidphase oxidation of hydrocarbons to acetic acid.
Formic acid is also produced by :
(a) treating sodium formate and sodium acid formate with sulfuric acid at low temperatures followed by distillation or
(b) direct synthesis from water and CO2 under pressure and in the presence of catalysts.

Biotechnological Production
Formic acid is generally produced by chemical synthesis .
However, biotechnological routes are described in literature.
First, formic acid could be produced from hydrogen and bicarbonate by whole-cell catalysis using a methanogen.
Concentrations up to 1.02 mol.L-1 (47 g.L-1) have been reached within 50 h.
Another example is the formation of formic acid and ethanol as co-products by microbial fermentation of glycerol with genetically modified organisms.
In small-scale experiments, 10 g.L-1 glycerol has been converted to 4.8 g.L-1 formate with a volumetric productivity of 3.18 mmol.L-1.h-1 and a yield of 0.92 mol formate per mole glycerol using an engineered E. coli strain.

Purification Methods
Anhydrous formic acid can be obtained by direct fractional distillation under reduced pressure, the receiver being cooled in ice-water.
The use of P2O5 or CaCl2 as dehydrating agents is unsatisfactory.
Reagent grade 88% formic acid can be satisfactorily dried by refluxing with phthalic anhydride for 6hours and then distilling Formic acid.
Alternatively, if Formic acid is left in contact with freshly prepared anhydrous CuSO4 for several days about one half of the water is removed from 88% formic acid; distillation then removes the remainder.
Boric anhydride (prepared by melting boric acid in an oven at a high temperature, cooling in a desiccator, and powdering) is a suitable dehydrating agent for 98% formic acid; after prolonged stirring with the anhydride the formic acid is distilled under vacuum.
Formic acid can be further purified by fractional crystallisation using partial freezing.

Formic acid is not a typical carboxylic acid; it is distinguished by its acid strength, Formic acids failure to form an anhydride, and Formic acids reactivity as a reducing agent—a property due to the ―CHO group, which imparts some of the character of an aldehyde.
The methyl and ethyl esters of formic acid are commercially produced.
Concentrated sulfuric acid dehydrates formic acid to carbon monoxide.

Pure formic acid is a colourless, fuming liquid with a pungent odour; it irritates the mucous membranes and blisters the skin.
Formic Acid freezes at 8.4 °C (47.1 °F) and boils at 100.7 °C (213.3 °F).

Methanoic acid, better known as formic acid [64-18-6], HCOOH, M r 46.03, is a colorless, corrosive liquid with a pungent odor.
Formic Acid is completely miscible with water and many polar solvents but only partially miscible with hydrocarbons.

Formic acid derives Formic acids name from ants (lat. Formica) from which Formic acid was first obtained by dry distillation.
The first scientific study on its properties, “Concerning Some Un-Common Observations and Experiments Made with an Acid Juyce to be Found in Ants” was published as early as 1670 (1).

Formic acid and Formic acids salts are used primarily in the feed industry, grass silage, leather tanning, and anti-icing.
Other applications include textile dyeing and finishing, food additives, natural rubber, drilling fluids, and various chemical processes.

The worldwide production of formic acid was about 621 000 t/a in 2012.
Formic Acid is produced mainly by hydrolysis of methyl formate.
The other important method is acidolysis of formate salts.

Physical Properties
Formic acid, mp 8.3°C, bp 100.8°C (at 101.3 kPa), is a colorless, clear, corrosive liquid with a pungent odor.
Formic Acid is the strongest unsubstituted alkyl carboxylic acid (pK a 3.74).

Production
The formic acid processes practiced today are based mainly on two main routes: methyl formate hydrolysis and preparation of free formic acid from formates.

The methyl formate based process route is currently dominant.
Approximately 90% of the installed capacity is based on this on-purpose process.
The economic disadvantages of the methods earlier practiced led to the development of a process specifically dedicated to the production of formic acid with no undesirable byproducts.
In the 1970s, the hydrolysis of methyl formate to methanol and formic acid was developed commercially by various companies into an economically feasible method.

This process involves carbonylation of methanol and subsequent hydrolysis of the methyl formate produced.
The methanol resulting from this process is returned to the first stage.
Formic acid plants based on this process were started up at BASF (Federal Republic of Germany) in 1981 and Kemira (Finland) in 1982.
More recent large-scale producers using this route are the Chinese companies Feicheng Acid Chemicals and Luxi Chemical Group.

The other current production method involves formation of the free acid from its salts.
Mainly sodium formate [141-53-7] and calcium formate [544-17-2] are used for this purpose.
The acidolysis is normally carried out with sulfuric acid or phosphoric acid.
Sulfate or phosphate salts are produced as byproducts.

Formic acid used to be a byproduct in the production of acetic acid [64-19-7] by liquid-phase oxidation of butane or naphtha (→ Acetic Acid).
For many years, oxidation of hydrocarbons was the most important method of producing acetic acid. However, the preferred process today is carbonylation of methanol , in which formic acid is not formed.

The production of formic acid by hydrolysis of formamide [75-12-7] played an important role in Europe until the 1970s.;
However, the consumption of ammonia and sulfuric acid, along with the unavoidable production of ammonium sulfate, has made this process economically inferior.
Although other methods for producing formic acid have been patented, they do not appear to have been implemented industrially.

Uses
Because of Formic acids acidity, aldehydic nature, and reducing properties, formic acid is used in a variety of fields.
In contrast to mineral acids, formic acid evaporates without leaving any residue.

Silage
The term silage traditionally refers to ensilation of forage crops (mainly grasses) for feeding bovines on farms.
Consumption is dependent on climate; formic acid based ensiling is especially suitable for wet conditions.
Northern Europe is the main consumption area.

Ensiling is based on fermentation under anaerobic conditions, whereby lactic acid produced by lactic acid bacteria preserve the silage.
Lactic acid lowers the pH and thus prevents unwanted microbial growth.
Addition of formic acid results in a rapid initial drop in pH, which promotes the growth of lactic acid bacteria and suppresses the growth of bacteria that produce undesirable compounds such as butyric acid. When the pH drop is enhanced with formic acid, spontaneous fermentation is restricted.
Advantages include more residual sugars and protein.
Restriction of fermentation is known to have a positive effect on voluntary intake in dairy cow feeding and thus enhances milk production.

Forage crops such as grass, corn, clover, and alfalfa are cut, chopped, and then fermented in silos or bales covered with airtight film.
Formic acid is excellently suited to ensiling difficult-to-ensile materials, especially wet or low-sugar fodder plants, which may also have high buffering capacity.
Formic acid is also used to restrict fermentation when ensiling crimped high-moisture grain.
Food and beverage industry byproducts, such as spent mash from breweries, can be preserved with formic acid solutions to give long-shelf-life animal feed.
Formic acid is used in different formulations, sometimes as mixtures with other short-chain organic acids such as propionic acid and often buffered with a formate salt for handling safety and reduced corrosion.

Leather
One of the biggest users of formic acid globally is the tanning industry.
As the tanning industry has moved to lower-cost countries, the growth figures in Asia have been very high, compensating the decline in Europe and North America.
China is the largest producer of leather, accounting for about 30% of world production.

Pretreatment of hides leaves them in a slightly alkaline state, but tanning requires acidic conditions.
Therefore, the hides are treated with acid (typically sulfuric and formic acids) prior to tanning in a process called pickling.
Without this conditioning, the tanning agents would quickly become fixed at the surface of the hide, while Formic acids inner layer would remain raw.
Sulfuric acid reduces the pH of the liquor, while formic acid is capable of penetrating through the collagen fibers rapidly and homogeneously.
Formic Acid ensures that the tanning agent (usually basic chromium sulfate) will penetrate the entire thickness of the hide.
In leather dyeing, formic acid is used as a leveling agent to aid in moving the dye from one area of the leather to another, resulting in more uniform and smoother dye distribution.

Textiles
In the textile industry, formic acid is used as a pH-regulating agent in dyeing wool, nylon, and other natural and synthetic fibers with acid and chrome dyes.
In addition, formic acid is used to neutralize alkaline solutions and facilitate rinsing during laundering.

Improving living standards and increased fiber production, especially for export markets, are expected to increase demand for formic acid in textile dyeing and finishing in Asia.

Feed Additives
Organic acids and salts have a long history in the feed industry, which commonly uses them as preservatives and for acidification of piglet diets.
Since 2006 when the EU banned antibiotic growth promoters (AGPs), the use of organic acids in feed has increased.

Formic acid has a strong acidification effect but also antimicrobial effects, which are used to protect feed and drinking water against bacterial contamination.
Formic acid is very effective against Salmonella, Escherichia, and Campylobacter at pH 4.0.
Formic Acid acts positively on the gut flora of animals and can improve both the apparent digestibility of energy and protein and the absorption and retention of some minerals.
Formic Acid seems to enhance the growth performance of weaned piglets and fattening pigs at lower dosages than other organic acids and salts.
For the effect of organic acids in pig feed, see, for example.

In the poultry industry formic acid has long been used for to prevent growth of pathogens in feed and feed materials.
Blends of formic acid with propionic acid, lactic acid or medium-chain fatty acids have broader antimicrobial effects than formic acid alone.

Pharmaceuticals and Food Additives
Pharmaceuticals and food chemicals have been estimated to be the largest single sector of formic acid use in Asia (mainly in China).

Formic acid is used as a synthetic intermediate for various pharmaceuticals and food chemicals, including synthetic insulin (purification of recombinant insulin), caffeine, aspartame, and vitamin B1.
Formic Acid is also used widely for pH adjustment during the manufacturing of various chemicals.
Other applications in food include Salmonella decontamination and use as a preservative (E236, allowed in the USA but not in the EU, Australia, and New Zeeland), and as flavoring agent.

The use of formic acid in food preservation includes fumigation of fruit such as apples and cherries to reduce post-harvest decay.
Formic acid is especially effective in destroying fungal spores on surfaces and containers in which fruits are stored.
In some food preservation applications, formic acid is blended with lactic and/or propionic acid.
The mixture is minimally corrosive, but due to Formic acids low pH, Formic acid helps destroy harmful microorganisms and prevents their propagation, thus prolonging the shelf life of the product.

Other Uses
Rubber Coagulation
Formic acid is the preferred choice for coagulating latex, which is a suspension of microscopic natural rubber particles (polyisoprene) in an aqueous medium.
The surfaces of the latex particles are charged, which creates repulsion between them preventing coagulation.
In the coagulation process, formic acid neutralizes these charges, eliminating the repulsion.
The process results in a consistent high-quality natural rubber product.
The use of stronger acids makes the pH drop too fast and inhomogeneously.
As a result, the latex coagulates unevenly, which may affect Formic acids mechanical properties.
Weaker acids, such as acetic acid, are less efficient than formic acid and result in much higher acid consumption.

Gas Desulfurization
Formic acid is used as a desulfurization catalyst in flue gas desulfurization for coal-fired power plants.
Sulfur, whose content in coal can be as high as 5%, is released as sulfur dioxide in the firing process.
Capturing sulfur dioxide by passing the flue gas through an aqueous limestone slurry results in gypsum (calcium sulfate).
Adding formic acid to the desulfurization cycle increases the efficiency of sulfur separation.

10.6.3 Well Acidifiers
Formic acid is used in the stimulation of high-temperature wells in oil and gas fields when the conventional hydrochloric acid (HCl) systems cannot be adequately inhibited.
Well acidizing is achieved by pumping acid into the well to dissolve limestone, dolomite, and calcite cement between the sediment grains of the reservoir rocks.
Formic acid has the advantage of good inhibition against pipe corrosion at temperatures as high as 200°C (possibly caused by a protective layer of decomposition products).

Mixed HCl–formic acid can offer further advantages.
Formic acid does not dissociate in the presence of HCl, so there is no reaction with the carbonate until the HCl is virtually spent.
HCl/formic mixtures can thus achieve greater penetration.

Cleaning Agents
Formic acid has some use as an active ingredient in commercial cleaning products such as descalers, rust removers, multipurpose cleaners and degreasers, and institutional laundry products.
In descaling, calcium salt forms when calcium carbonate is dissolved by an acid.
The more readily soluble this salt is, the lower is the risk of salt deposits that reduce acid effectiveness.
In bathroom cleaners Formic acid is claimed to combine the properties of an efficient descaling agent with those of a biodegradable biocide.

Solvent Use
Formic acid can be used to dissolve polyamides (e.g., nylon 66 and nylon 46) or silk to prepare fibers and membranes.
Formic Acid is also a useful component in semiconductor cleaning solutions.

Formic acid (systematically called methanoic acid) is the simplest carboxylic acid.
Formic Acid is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings.
Formic Acid is commonly used as a preservative and antibacterial agent in livestock feed.

Key Points
-formic acid is a clear, colourless liquid with a pungent odour
-Formic acid is used as a pesticide in hay and animal feed, in wart removal, as a preservative and in household descalers
-formic acid may be found at very low levels in the environment
-the stings of some ants and nettles may contain a small amount of formic acid
-ingestion causes immediate burning of the mouth and throat, breathing difficulty, drooling, difficulty swallowing, stomach pain and vomiting
-skin contact with formic acid can cause pain, burns and ulcers
-eye contact causes pain, twitching of the eyelids, watering eyes, inflammation, sensitivity to light and burns
-individuals with breathing problems such as asthmatics may be more sensitive to the effects of inhaling formic acid

What is formic acid?
Formic acid is a clear, colourless liquid with a pungent odour.

What is formic acid used for?
Formic acid is mainly used as a preservative and antibacterial agent in livestock feed.
Formic Acid is sprayed on animal feed or fresh hay to reduce the rate of decay and is used as a pesticide to treat and control mites that infest honey bee hives.
Formic Acid is also used to manufacture other chemicals, in wart removal treatments and may be found in household descalers.

How does formic acid get into the environment?
Formic acid can enter the environment during its production and use in industry.
Formic Acid may leach into water and soil where Formic acid biodegrades and vapours in the air will be degraded by sunlight.
As a result, there are very low levels of formic acid in the environment.

Formic acid is a common component of reverse-phase mobile phases that provide protons for LC/MS analysis.
The presence of a low concentration of formic acid in the mobile phase is also known to improve the peak shapes of the resulting separation.
Unlike trifluoroacetic acid (TFA), formic acid is not an ion-pairing agent and Formic acid does not suppress MS ionization of polypeptides when used as a mobile-phase component.

Roles Classification
Chemical Role(s):
solvent
A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
protic solvent
A polar solvent that is capable of acting as a hydron (proton) donor.
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )

Biological Role(s):
antibacterial agent
A substance (or active part thereof) that kills or slows the growth of bacteria.
metabolite
Any intermediate or product resulting from metabolism.
The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.

Application(s):
solvent
A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
astringent
A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.
protic solvent
A polar solvent that is capable of acting as a hydron (proton) donor.

Formic acid is the simplest carboxylic acid. Formate is an intermediate in normal metabolism.
Formic Acid takes part in the metabolism of one-carbon compounds and Formic acids carbon may appear in methyl groups undergoing transmethylation.
Formic Acid is eventually oxidized to carbon dioxide.
Formate is typically produced as a byproduct in the production of acetate.
Formic Acid is responsible for both metabolic acidosis and disrupting mitochondrial electron transport and energy production by inhibiting cytochrome oxidase activity, the terminal electron acceptor of the electron transport chain.
Cell death from cytochrome oxidase inhibition by formate is believed to result partly from depletion of ATP, reducing energy concentrations so that essential cell functions cannot be maintained.

Furthermore, inhibition of cytochrome oxidase by formate may also cause cell death by increased production of cytotoxic reactive oxygen species (ROS) secondary to the blockade of the electron transport chain.
In nature, formic acid is found in the stings and bites of many insects of the order Hymenoptera, including bees and ants.
The principal use of formic acid is as a preservative and antibacterial agent in livestock feed.
When sprayed on fresh hay or other silage, Formic acid arrests certain decay processes and causes the feed to retain Formic acids nutritive value longer.
Urinary formate is produced by Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Enterobacter, Acinetobacter, Proteus mirabilis, Citrobacter frundii, Enterococcus faecalis, Streptococcus group B, Staphylococcus saprophyticus

Formic Acid has one carboxylic group.
Formic Acid is a colorless liquid.
Formic Acid is used in the leather tanning process, in feed for preservation and acidification, as intermediate in various pharmaceuticals and fine chemicals and as active ingredient in cleaning agents.

Formic Acid Uses
Animal Feed Additive
The majority of formic acid used worldwide is within the agriculture sector.
Here, Formic acid is used as an additive in animal feed and harvested silage where, in silage, Formic acid works to provide antibacterial protection as well as to support fermentation at lower temperatures.
This reduces the time Formic acid takes to produce the finished product whilst also preserving the nutritional value of the feed.

Cleaning Products
Formic acid provides an alternative to the many traditional acids used in cleaning products, such as phosphoric and citric acid, offering a reduced cost with highly effective descaling capabilities and a low environmental impact.
Formic Acid can be found in de-scalers (kettle, coffee machines, brewery descalers etc), and bathroom cleaners to name a few.

Fish Silage
Fish silage is a valuable feed input for livestock and fertiliser in crop production.

The silage consists of minced fish by-products or minced whole fish not suitable for human consumption with an added organic acid for preservation.
The formic acid lowers the pH and inhibits mold growth (other acids such as phosphoric acid will only lower the pH so a separate inhibitor, such as propionic acid needs to be added if not using Formic).

Leather Processing
The leather industry uses formic acid for tanning and dye fixing.
Tanning is the process of treating animal skins and hides to produce leather, this involves a process which permanently alters the protein structure of skin, making Formic acid more durable and less susceptible to decomposition.

Pharmaceuticals
The pharmaceuticals industry uses formic acid in the production of various active pharmaceutical ingredients.

Rubber Industry
Formic acid is used as a coagulant (turn a liquid into a solid or semi solid state) in the rubber industry to shape the product and create different products.

Textile Processing
After an alkaline textile processing step formic acid is added to neutralise the excess of sodium hydroxide and adjust the pH back to neutral.
Formic Acid is used in cotton pre-treatment, bleaching, mercerizing (a process to help fibers absorb more water/dye to increase vibrancy), dyeing and cleaning.

Water Treatment
Formic Acid is used as a pH adjuster to treat wastewater and sewage in water treatment plants.
Formic Acid is a more cost-effective option over phosphoric and sulphuric acid because Formic acid degrades in effluents without producing emissions/leaving behind phosphates resulting in a reduction of waste-water charges.
Other uses for formic acid include use in adhesives, corrosion inhibitors, surface agents, antifreeze products, construction materials, paints, inks and plastics.

Product description
Formic acid is abundant in nature and has been used for many years as an environmentally friendly alternative in industries such as textiles, natural rubber and leather processing.
Formic Acid is also used in agriculture, as well as in the production of medicines, cosmetics, detergents and disinfectants.
Formic Acid has excellent properties in controlling acidity, while at the same time effectively restricting microbial growth.

Formic acid is the strongest of the simple, unsaturated carboxylic acids.
Furthermore, unlike other organic acids, formic acid has the advantage of being both a carboxylic acid and an aldehyde.
Formic Acid acts, therefore, both as an acidifying and a reducing agent, which clearly gives formic acid enhanced potential for use in industry.

Applications/uses
Hard surface care
HTF - pharmaceutical processing
Industrial cleaners
Institutional cleaners
Tannery
Textile

Formic Acid is used for decalcifier; reducer in dyeing for wool fast colours; dehairing and plumping hides; tanning; electroplating; coagulating rubber latex; silage and grain preservation;aidditive in regenerating old rubber; solvents of perfume; lacquers; alkylating agent for alcohols; carboxylating agent for tertiary compounds.
Formic acid, also called methanoic acid), is the simplest and has the lowest mole weight of the carboxylic acids, in which a single hydrogen atom is attached to the carboxyl group (HCOOH).
If a methyl group is attached to the carboxyl group, the compound is acetic acid.
Formic Acid occurs naturally in the body of ants and in the stingers of bees.
Functionally, Formic acid is not only an acid but also analdehyde; Formic acid reacts with alcohols to form esters as an acid and Formic acid is easily oxidized which imparts some of the character of an aldehyde.
Pure formic acid is a colorless, toxic, corrosive and fuming liquid, freezing at 8.4 C and boiling at 100.7 C.

Formic Acid is soluble in water, ether, and alcohol.
Formic Acid irritates the mucous membranes and blisters the skin.
Formic Acid is prepared commercially from sodiumformate with the reaction of condensed sulfuric acid.
Formic acid is used as a chemical intermediate and solvent, and as a disinfectant.
Formic Acid is also in processing textiles and leathers, electroplating and coagulating latex rubber.

APPLICATIONS
Formic Acid is used for decalcifier; reducer in dyeing for wool fast colours; dehairing and plumping hides; tanning; electroplating; coagulating rubber latex; silage and grain preservation;aidditive in regenerating old rubber; solvents of perfume; lacquers; alkylating agent for alcohols; carboxylating agent for tertiary compounds.
Formic Acid is also used as an intermediate for the production of a wide variety of products in the chemicals and pharmaceutical industries.
Formic acid is abundant in nature and has been used for many years as an environmentally friendly alternative in industries such as textiles, natural rubber and leather processing.
Formic Acid is also used in agriculture, as well as in the production of medicines, cosmetics, detergents and disinfectants.
Formic Acid has excellent properties in controlling acidity, while at the same time effectively restricting microbial growth.
Formic Acid is used in dyeing and finishing of textiles, leather treatment, manufacture of fumigants, insecticides, refrigerants, solvents for perfumes, lacquers, electroplating, antiseptic in brewing, natural latex coagulant, ore flotation, and vinyl resin plasticizers.

What Does Formic Acid Mean?
Formic acid is the simple form of carboxylic acid, and is also known by the systematic IUPAC name as methanoic acid.
Formic acid has the chemical formula HCOOH.
Formic Acid is formed naturally in the venom of bees and ants, and is considered an important intermediate in chemical synthesis.
For commercial purposes formic acid is primarily used as a preservative and antibacterial agent.

Chemical Structure and Properties
Formic acid is the simplest member of the carboxylic acid family.
Formic acid's also known as methanoic acid.
The chemical's molecular formula is HCOOH.
The molecule is composed of a carboxyl group (COOH) with a hydrogen atom attached.
In the carboxyl group, the carbon atom has a double bond joining Formic acid to the oxygen atom and a single bond joining Formic acid to the hydroxyl (OH) group, as shown in the illustration above.

Formic acid can be made synthetically in laboratories.
In nature, Formic acid usually exists in the form of a colorless liquid.
This liquid freezes at 8.3 degrees Celsius (46.9 degrees Fahrenheit) and boils at 100.7 degrees Celsius. (213.3 degrees Fahrenheit).
Formic Acid has a strong odor and is often described as having a "pungent" smell.

Formula and structure: The chemical formula of formic acid is HCOOH or HCO2H.
Formic acids molecular formula is CH2O2 and its molar mass is 46.02 g/mol.
Formic acids chemical structure is shown below.
Formic Acid consists of a single carboxylic acid group (COOH) attached to a hydrogen atom.

Preparation: Formic acid is prepared through several routes.
Formic Acid is commonly prepared by reacting sodium formate with sulfuric acid.
Formic Acid is also prepared by the reaction of formamide (HCONH2) with sulfuric acid or by the hydrolysis of methyl formate (HCO2CH3), as shown below:
2 HCONH2 + 2H2O + H2SO4 → 2HCO2H + (NH4)2SO4
HCO2CH3 + H2O → HCO2H + CH3OH

Physical properties: Pure formic acid is a colorless liquid with a corrosive and pungent odor.
Formic acids density is 1.22 g/mL, melting point is 8.4 °C and boiling point is 101 °C.
Formic Acid is completely miscible with water

Chemical properties: Formic acid is a weak acid which behaves as a typical carboxylic acid and also has some aldehyde-like properties.
Formic Acid readily reacts with alcohols to form esters.
Formic acid decomposes in the presence of acids or heat to give carbon monoxide (CO) and water.
In the presence of platinum, Formic acid decomposes to give carbon dioxide and hydrogen instead.

Uses: Formic acid is mainly used as a preservative, antibacterial agent, artificial flavoring agent, and in household and industrial cleaning products.
Formic Acid is also used in leather tanning, dyeing, textile finishing, and rubber production.

Natural Formic acid occurrence
In nature, formic acid is found in most ants and in stingless bees of the genus Oxytrigona.
The wood ants from the genus Formica can spray formic acid on their prey or to defend the nest.
The puss moth caterpillar (Cerura vinula) will spray Formic acid as well when threatened by predators.
Formic acid is also found in the trichomes of stinging nettle (Urtica dioica).
Formic acid is a naturally occurring component of the atmosphere primarily due to forest emissions.
From methyl formate and formamide
When methanol and carbon monoxide are combined in the presence of a strong base, the result is methyl formate, according to the chemical equation:

CH3OH + CO → HCO2CH3
In industry, this reaction is performed in the liquid phase at elevated pressure.
Typical reaction conditions are 80 °C and 40 atm.
The most widely used base is sodium methoxide.
Hydrolysis of the methyl formate produces formic acid:

HCO2CH3 + H2O → HCOOH + CH3OH
Efficient hydrolysis of methyl formate requires a large excess of water.
Some routes proceed indirectly by first treating the methyl formate with ammonia to give formamide, which is then hydrolyzed with sulfuric acid:

HCO2CH3 + NH3 → HC(O)NH2 + CH3OH
2 HC(O)NH2 + 2H2O + H2SO4 → 2HCO2H + (NH4)2SO4
A disadvantage of this approach is the need to dispose of the ammonium sulfate byproduct.
This problem has led some manufacturers to develop energy-efficient methods of separating formic acid from the excess water used in direct hydrolysis.
In one of these processes, used by BASF, the formic acid is removed from the water by liquid-liquid extraction with an organic base.

Niche and obsolete chemical routes
By-product of acetic acid production
A significant amount of formic acid is produced as a byproduct in the manufacture of other chemicals.
At one time, acetic acid was produced on a large scale by oxidation of alkanes, by a process that cogenerates significant formic acid.
This oxidative route to acetic acid has declined in importance so that the aforementioned dedicated routes to formic acid have become more important.

Hydrogenation of carbon dioxide
The catalytic hydrogenation of CO2 to formic acid has long been studied.
This reaction can be conducted homogeneously.

Formic acid Oxidation of biomass
Formic acid can also be obtained by aqueous catalytic partial oxidation of wet biomass by the OxFA process.
A Keggin-type polyoxometalate (H5PV2Mo10O40) is used as the homogeneous catalyst to convert sugars, wood, waste paper, or cyanobacteria to formic acid and CO2 as the sole byproduct.
Yields of up to 53% formic acid can be achieved.

Formic acid Laboratory methods
In the laboratory, formic acid can be obtained by heating oxalic acid in glycerol and extraction by steam distillation.
Glycerol acts as a catalyst, as the reaction proceeds through a glyceryl oxalate intermediate.
If the reaction mixture is heated to higher temperatures, allyl alcohol results.
The net reaction is thus:
C2O4H2 → CO2H2 + CO2

Another illustrative method involves the reaction between lead formate and hydrogen sulfide, driven by the formation of lead sulfide.
Pb(HCOO)2 + H2S → 2HCOOH + PbS

Formic acid Electrochemical production
Formic acid has been reported that formate can be formed by the electrochemical reduction of CO2 (in the form of bicarbonate) at a lead cathode at pH 8.6:
HCO−3 + H2O + 2e− → HCO−2 + 2OH− or CO2 + H2O + 2e− → HCO−2 + OH−
If the feed is CO2 and oxygen is evolved at the anode, the total reaction is:
CO2 + OH− → HCO−2 + 1/2 O2

This has been proposed as a large-scale source of formate by various groups.
The formate could be used as feed to modified E. coli bacteria for producing biomass.
There exist natural microbes that can feed on formic acid or formate (see Methylotroph).

Formic acid Biosynthesis
Formic acid is named after ants which have high concentrations of the compound in their venom.
In ants, formic acid is derived from serine through a 5,10-methenyltetrahydrofolate intermediate.
The conjugate base of formic acid, formate, also occurs widely in nature.
An assay for formic acid in body fluids, designed for determination of formate after methanol poisoning, is based on the reaction of formate with bacterial formate dehydrogenase.

Formic acid Artificial photosynthesis
In August 2020 researchers at Cambridge University announced a stand-alone advanced ‘photosheet’ technology that converts sunlight, carbon dioxide and water into oxygen and formic acid with no other inputs.

IUPAC names
Ameisensäure
Ameisensäure
carboxylic acid
CH202
Ester
FORMIC ACID
Formic Acid
Formic acid
formic acid
Formic Acid
Formic acid
formic acid
formic acid 85 %
Formic Acid 85%
formic acid 90-100%
Formic Acid [for General Organic Chemistry]
formic acid … %
formic acid...%
Formira ,Formisoton , Formylic acid
Hydrogen carboxylic acid
kwas metanowy
METANOIC ACID
Methanoic Acid
Methanoic acid
methanoic acid
Methansäure
methansäure
Acide formique
acideformique
acideformique(french)
Acido formico
acidoformico
Add-F
Kwas metaniowy
kwasmetaniowy
kwasmetaniowy(polish)
Kyselina mravenci
kyselinamravenci
kyselinamravenci(czech)
Methanoicacidmonomer
Methansαure
Mierenzuur
Myrmicyl
Rcra waste number U123
Formic acid about 85%
FormicacidAmeisensure
FORMOL
FORMALDE-FRESH
FORMALDE-FRESH SOLUTION
FORMALDE-FRESH SOLUTION, BUFFERED
FORMALDEHYDE, BUFFERED
FORMALDEHYDE, CARSON-MILLON
METHANONE
METHYL ALDEHYDE
Formate Ion Chromatography Standard Solution Fluka
FORMIC ACID 98-100 %, EXTRA PURE, DAC, F
FORMIC ACID FCC
FORMIC ACID, >=96%, A.C.S. REAGENT
FORMIC ACID, 95-97%
FORMIC ACID SOLUTION, 1.0 M IN WATER
FORMIC ACID DIST. 1 L
FORMIC ACID APPROX. 85% TECHNICAL 5 L
FORMIC ACID 85 %, PURE
AGILENT FORMIC ACID-REAGENT GRADE 1X5ML
FORMIC ACID, 88%, A.C.S. REAGENT
FORMIC ACID, FOR MASS SPECTROSCOPY
Formicacid,97%
Formic acid, for analysis ACS, 88%
Formic acid, for analysis, 99+%
Formic acid, pure, 99%
FORMIC ACID, 88% ENVIRONMENTAL GRADE
FORMIC ACID, 88% REAGENT (ACS)
FORMIC ACID, 88% SUPERIOR REAGENT (ACS)
FORMIC ACID, 88% VERITASDOUBLE DISTILLED
formate standard for ic
FORMICACID,90%,REAGENT,ACS(BULK
FORMICACID,96%,REAGENT,ACS
FORMICACID,TECHNICAL
FORMIC ACID, ACS, 88-91%
FORMIC ACID 98-100 %, PURISS. P.A.,REAG. ACS, REAG. PH. EUR.
FORMIC ACID FREE ACID
FORMIC ACID 98 - 100% GR ACS
FORMIC ACID PESTICIDE GRADE 98-100%
FORMIC ACID 98 - 100% EXTRA PURE, FCC DAC
FORMIC ACID (ANHYDROUS ) GC STANDARD

Regulatory process names:
Formic acid
Formic acid
formic acid
formic acid ... %
FORMIC ACID with more than 85% acid by mass
FORMIC ACID with not less than 10% but not more than 85% acid by mass
FORMIC ACID with not less than 5% but less than 10% acid by mass
formic acid … %

Translated names
...% skruzdžių rūgštis (lt)
Acid formic (ro)
acid formic…% (ro)
Acide formique (fr)
acide formique à …% (fr)
Acido formico (it)
acido formico ... % (it)
Ameisensäure (de)
Ameisensäure ... % (de)
Aċidu formiku (mt)
Formhape (sipelghape) … % (et)
Formic acid (no)
Hangyasav (hu)
hangyasav …% (hu)
Kwas mrówkowy (pl)
kwas mrówkowy ... % (pl)
kyselina mravenčí (cs)
kyselina mravčia (sk)
kyselina mravčia ... % (sk)
maursyre ... % (no)
Mierenzuur (nl)
mierenzuur ... % (nl)
mravenčí kyselina ...% (cs)
Mravlja kiselina (hr)
mravlja kiselina ... % (hr)
Mravljinčna kislina (sl)
mravljična kislina...% (sl)
Muurahaishappo (fi)
Muurahaishappo... % (fi)
myresyre (da)
myresyre ... % (da)
Myrsyra (sv)
myrsyra ... % (sv)
Sipelghape (et)
Skruzdžių rūgštis (lt)
Skudrskābe (lv)
Ácido fórmico (es)
Ácido fórmico (pt)
ácido fórmico ... % (es)
ácido fórmico ... % (pt)
Мравчена киселина (bg)
мравчена киселина ... % (bg)
…% skudrskābe (lv)

CAS names
Formic acid

IUPAC names
C&L Inventory
carboxylic acid
CH202
Ester
FORMIC ACID
Formic Acid
Formic acid
formic acid
Formic Acid
Formic acid
formic acid
formic acid 85 %
Formic Acid 85%
formic acid 90-100%
Formic Acid [for General Organic Chemistry]
formic acid … %
formic acid...%
Formira ,Formisoton , Formylic acid
Hydrogen carboxylic acid
kwas metanowy
METANOIC ACID
Methanoic Acid
Methanoic acid
methanoic acid
Methansäure
methansäure
Reaction mass of benzyl alcohol and benzyl formate and sodium benzothiazol-2-yl sulphide and 2-(heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol and Benzene, C10-13-alkyl derivs.

FORMIC ACID

Formic acid, also known as methanoic acid, is a chemical compound with the formula HCOOH.
Formic acid is the simplest carboxylic acid and is composed of a carboxyl group (COOH) attached to a hydrogen atom.
Formic acid occurs naturally in certain plants and is also produced synthetically for various industrial applications.
Formic acid is a colorless liquid with a pungent, sharp odor.

CAS Number: 64-18-6
EC Number: 200-579-1



APPLICATIONS


Formic acid is widely used in agriculture as a feed preservative and to enhance the quality of animal feed.
Formic acid finds application in the chemical industry as a raw material for the production of various chemicals, including pharmaceuticals, dyes, and pesticides.
In the leather industry, formic acid is utilized during the tanning process to remove hair and other impurities from hides.

The textile industry uses formic acid as a pH regulator and dye fixative in the dyeing and printing of fabrics.
Formic acid acts as a coagulant in the rubber industry, aiding in the production of latex rubber.
Formic acid is found in cleaning agents as a disinfectant, antimicrobial agent, and pH adjuster.

Formic acid is used as a preservative in personal care products, cosmetics, and cleaning formulations.
Formic acid is employed in electroplating baths as an acidifier and pH adjuster.
The oil and gas industry uses formic acid for acidizing wells, enhancing oil production by removing formation damage.

Formic acid acts as a biocide in water treatment applications, controlling microbial growth.
Formic acid is used in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
In analytical chemistry, it serves as a solvent and reagent in various techniques, such as high-performance liquid chromatography (HPLC).

Formic acid can be used as an animal repellent to deter pests and unwanted animals.
Formic acid is employed for descaling and cleaning industrial equipment, particularly in applications involving mineral deposits.
Formic acid is utilized as a pH adjuster in various applications, including personal care products, laboratory solutions, and industrial processes.
Formic acid finds application in wastewater treatment to control pH and remove heavy metals.
In the food industry, it is used as a preservative and acidifier in certain food products and food processing.

Beekeepers use formic acid in some treatments to control varroa mites in beehives.
Formic acid can be used in wood preservation formulations to protect against decay and fungal growth.
Formic acid is employed in the production of adhesives and sealants as a pH adjuster and catalyst.

Formic acid is used for metal cleaning, surface preparation, and metal passivation.
In medical and laboratory settings, formic acid can be used as a disinfectant.
Formic acid finds application in the processing of cellulose-based materials, such as paper and textiles.

Formic acid is used for concrete and cement curing in the construction industry.
Formic acid is being explored as a potential fuel for fuel cell applications due to its high energy density and ease of storage.

Formic acid is used in the production of leather goods, such as shoes, belts, and bags.
Formic acid finds application in the manufacturing of synthetic fibers, including nylon and polyester.

Formic acid is utilized in the production of rubber and plastic foams, such as those used in insulation materials.
Formic acid is employed in the production of adhesives and bonding agents for various applications.
Formic acid is used in the petroleum industry for oil well stimulation and acidizing operations.

Formic acid serves as a reducing agent in chemical reactions, particularly in the synthesis of pharmaceuticals and fine chemicals.
Formic acid is employed in the production of detergents and cleaning products as a pH adjuster and stain remover.
Formic acid can be used as a pesticide in agriculture to control pests and insects.

Formic acid is utilized in the formulation of corrosion inhibitors for metal protection.
Formic acid is used in the production of flavors and fragrances for the food and cosmetic industries.

In the automotive industry, formic acid finds application as an additive in coolant formulations.
Formic acid is utilized as a mordant in textile dyeing to improve colorfastness and fixation of dyes.

Formic acid is employed in the production of artificial sweeteners, such as sodium saccharin.
Formic acid can be used as a pH adjuster in swimming pools and water treatment applications.
Formic acid is utilized in the preservation of biological specimens and tissue samples.

Formic acid finds application as a de-scaling agent for removing mineral deposits from household appliances and industrial equipment.
In the photography industry, formic acid can be used as a developing agent for black and white films.
Formic acid is employed as a cleaning agent for circuit boards and electronic components.

Formic acid can be used as a food acidifier and preservative in the brewing and wine industries.
Formic acid is used in the production of metal salts, such as formates, which have various industrial applications.
Formic acid is utilized in the synthesis of certain polymers and resins for coatings and adhesives.
In the paper industry, it can be used as a paper strength additive to improve paper properties.

Formic acid is employed as a catalyst in chemical reactions, particularly in the production of esters and amides.
Formic acid is used as a pH adjuster and buffering agent in cosmetic formulations.
Formic acid finds application in the production of fuel additives, such as oxygenated fuels and biodiesel.


Formic acid has a variety of applications across different industries.
Here are some common applications of formic acid:

Agriculture:
Formic acid is used as a feed preservative and as a treatment for animal feed to inhibit the growth of bacteria and improve feed quality.

Chemical Industry:
Formic acid serves as a raw material for the production of various chemicals, including pharmaceuticals, dyes, and pesticides.

Leather Industry:
Formic acid is used in the leather tanning process to remove hair and other impurities from animal hides.

Textile Industry:
Formic acid is utilized as a pH regulator and dye fixative in the dyeing and printing of textiles.

Rubber Industry:
Formic acid acts as a coagulant in the production of latex rubber, facilitating the formation of rubber particles.

Cleaning Agents:
Formic acid is found in some cleaning products as a disinfectant, antibacterial agent, and pH adjuster.

Preservatives:
Formic acid is used as a preservative in certain personal care products, cosmetics, and cleaning formulations.

Electroplating:
Formic acid is utilized in electroplating baths as an acidifier and pH adjuster.

Oil and Gas Industry:
Formic acid can be used for acidizing oil wells to remove formation damage and enhance oil production.

Biocides:
Formic acid is employed as a biocide in water treatment applications to control microbial growth.

Pharmaceuticals:
Formic acid is used in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).

Analytical Chemistry:
Formic acid is used as a solvent and reagent in various analytical techniques, such as high-performance liquid chromatography (HPLC).

Animal Repellents:
Formic acid can be used as an animal repellent to deter pests and unwanted animals.

Cleaning and Descaling:
Formic acid is used for descaling and cleaning industrial equipment, particularly in applications involving mineral deposits.

pH Regulation:
Formic acid is utilized as a pH adjuster in various applications, including personal care products, laboratory solutions, and industrial processes.

Environmental Applications:
Formic acid can be used for wastewater treatment to control pH and remove heavy metals.

Food Industry:
In some cases, formic acid is used as a preservative and acidifier in food products and food processing.

Beekeeping:
Formic acid is used in some treatments for the control of varroa mites in beehives.

Wood Preservation:
Formic acid can be used in wood preservation formulations to protect against decay and fungal growth.

Adhesive Industry:
Formic acid is utilized in the production of adhesives and sealants as a pH adjuster and catalyst.

Metal Treatment:
Formic acid is used for metal cleaning, surface preparation, and metal passivation.

Disinfection:
Formic acid can be used as a disinfectant in medical and laboratory settings.

Cellulosic Materials:
Formic acid is used in the processing of cellulose-based materials, such as paper and textiles.

Construction Industry:
Formic acid is utilized for concrete and cement curing applications.

Fuel Cells:
Formic acid is being explored as a potential fuel for fuel cell applications due to its high energy density and ease of storage.



DESCRIPTION


Formic acid, also known as methanoic acid, is a chemical compound with the formula HCOOH.
Formic acid is the simplest carboxylic acid and is composed of a carboxyl group (COOH) attached to a hydrogen atom.
Formic acid occurs naturally in certain plants and is also produced synthetically for various industrial applications.


Formic acid is a colorless liquid with a pungent, sharp odor.
Formic acid is the simplest carboxylic acid, consisting of a carboxyl group (COOH) attached to a hydrogen atom.
Formic acid has a molecular formula of HCOOH and a molecular weight of 46.03 grams/mol.

Formic acid is highly soluble in water and many organic solvents.
The density of formic acid is 1.22 g/cm³.
Formic acid has a melting point of 8.4 °C (47.1 °F) and a boiling point of 100.8 °C (213.4 °F).

Formic acid is a volatile compound with a vapor pressure of 44 mmHg at 20 °C.
It is classified as an acidic substance, with a pH below 7.
The odor of formic acid can be described as strong, vinegar-like, or reminiscent of ant stings.

Formic acid is highly reactive and can act as both an acid and a reducing agent.
Formic acid can corrode or etch metals and can cause burns on contact with the skin and eyes.
Formic acid occurs naturally in certain plants and animals and is also produced synthetically for industrial purposes.
In agriculture, formic acid is used as a feed preservative and in the treatment of animal feed.

The chemical industry utilizes formic acid as a raw material in the production of various chemicals, including dyes and pharmaceuticals.
In the leather industry, it is used in the tanning process to remove hair and impurities from hides.
Formic acid is employed in the textile industry as a pH regulator and fixative for textile dyes.

Formic acid acts as a coagulant in the production of latex rubber in the rubber industry.
Some cleaning products contain formic acid as a disinfectant and antimicrobial agent.

Formic acid is used as a preservative in certain personal care products and cosmetics.
Formic acid is commonly used as a reagent in laboratory and research settings for various chemical reactions.

Formic acid can serve as a solvent for certain substances due to its miscibility with water and organic solvents.
Formic acid is utilized in some formulations of antifreeze to lower the freezing point of liquids.
Formic acid is considered a promising fuel for fuel cell applications due to its high energy density and storage convenience.

When handled, formic acid requires proper protective equipment and adherence to safety guidelines due to its corrosive nature.
The unique properties and versatile applications of formic acid make it an important chemical in several industries, ranging from agriculture to textile manufacturing and beyond.



PROPERTIES


Chemical Formula: HCOOH
Molecular Weight: 46.03 g/mol
Physical State: Colorless liquid
Odor: Pungent, acrid odor
Density: 1.22 g/cm³
Melting Point: 8.4 °C (46.1 °F)
Boiling Point: 100.8 °C (213.4 °F)
Solubility: Soluble in water, ethanol, ether, acetone, and other organic solvents
Vapor Pressure: 44 mmHg at 20 °C (68 °F)
Flash Point: 69 °C (156 °F)
Autoignition Temperature: 605 °C (1121 °F)
Viscosity: 1.46 cP at 20 °C (68 °F)
pH: Strongly acidic (pKa = 3.77)
Molecular Structure: It consists of a carboxylic acid group (COOH) attached to a hydrogen atom.
Reactivity: It is a highly reactive compound, capable of participating in various chemical reactions.
Hygroscopicity: Formic acid has hygroscopic properties, absorbing moisture from the surrounding environment.
Miscibility: It is miscible with many organic solvents and can form homogeneous solutions.
Corrosivity: Formic acid is corrosive to metals, particularly in concentrated form.
Stability: It is relatively stable under normal conditions, but can decompose upon exposure to heat or light.
Toxicity: Formic acid is toxic and can cause severe irritation, burns, and harm to living organisms.



FIRST AID


Inhalation:

Move the affected person to fresh air and ensure they are in a well-ventilated area.
If breathing is difficult, provide oxygen if available and seek immediate medical attention.
If the person is not breathing, perform artificial respiration, preferably using a mechanical device.


Skin Contact:

Remove contaminated clothing and immediately rinse the affected skin with plenty of water for at least 15 minutes.
Gently wash the affected area with mild soap and water.
Seek medical attention if skin irritation, redness, or burns occur.
Avoid applying creams or ointments without medical advice.


Eye Contact:

Rinse the eyes thoroughly with gently flowing water for at least 15 minutes, holding the eyelids open.
Remove contact lenses, if applicable, after rinsing for a few minutes.
Seek immediate medical attention, even if initial irritation is mild or absent.
Protect the unaffected eye during transportation to medical facilities.


Ingestion:

Do NOT induce vomiting unless instructed to do so by medical professionals.
Rinse the mouth thoroughly with water, but do not swallow it.

If a large amount of formic acid has been ingested or if the person is experiencing severe symptoms, seek immediate medical attention.
Provide medical personnel with all relevant information, including the quantity ingested and the time of exposure.


General Measures:

Remove the person from the contaminated area to prevent further exposure.
Remove contaminated clothing, taking care not to spread the chemical to unaffected areas.
Rinse any contaminated clothing thoroughly before reuse or dispose of it safely.

If the person shows signs of chemical burns, protect the affected area by loosely covering it with a sterile, non-stick bandage or cloth.
Provide supportive care as needed, such as maintaining airway, breathing, and circulation.
Do not administer any medication unless instructed to do so by medical professionals.



HANDLING AND STORAGE


Handling:

Personal Protection:
Always wear appropriate personal protective equipment (PPE) when handling formic acid, including chemical-resistant gloves, safety goggles, and a lab coat or protective clothing.
Consider using a chemical-resistant apron and face shield for additional protection, especially when handling larger quantities or working with concentrated solutions.
Ensure good ventilation in the work area to minimize the inhalation of vapors.

Safe Handling Practices:
Handle formic acid in a well-ventilated area or under local exhaust ventilation to prevent the buildup of vapors.
Avoid contact with skin, eyes, and clothing.
In case of contact, follow the first aid measures provided and remove contaminated clothing immediately.
Use appropriate tools, such as chemical-resistant containers and pumps, to transfer or dispense formic acid.

Do not eat, drink, or smoke while handling formic acid, as it is toxic if ingested.
Avoid inhaling vapors by keeping the container closed when not in use and using a fume hood or appropriate respiratory protection when necessary.
Do not mix formic acid with other chemicals without proper knowledge and guidance, as hazardous reactions may occur.

Spill and Leak Response:
In the event of a spill or leak, restrict access to the area and ensure that proper personal protective equipment is worn.
Absorb small spills with an appropriate absorbent material, such as vermiculite or sand, and transfer it to a suitable container for disposal.

For larger spills, contain the spill by constructing a barrier with sandbags or absorbent booms to prevent further spread.
Notify the appropriate authorities and follow local regulations for proper cleanup and disposal of spilled formic acid.


Storage:

Storage Conditions:
Store formic acid in a cool, dry, and well-ventilated area away from sources of heat, ignition, and direct sunlight.
Keep containers tightly closed and upright to prevent leakage or spills.
Store formic acid away from incompatible materials, such as strong oxidizers and bases, to prevent hazardous reactions.
Separate formic acid from flammable substances and reactive chemicals to minimize the risk of fire or chemical reactions.

Storage Containers:
Use appropriate containers for storing formic acid, such as high-density polyethylene (HDPE) or glass containers.
Ensure that containers are labeled with the name of the substance, hazard warnings, and appropriate safety information.
Check containers regularly for signs of damage or deterioration and replace them if necessary.

Handling of Drums and Containers:
When handling larger quantities of formic acid stored in drums or containers, use appropriate material handling equipment, such as drum dollies or forklifts.
Take precautions to prevent spills, leaks, or punctures during transportation and storage of drums or containers.
Follow local regulations for the proper handling, storage, and disposal of empty containers.



SYNONYMS


Methanoic acid
Hydrogen carboxylic acid
Aminic acid
Formylic acid
HCOOH (its chemical formula)
Ant sting
Ant acid
Formylic alcohol
Oxocarbinic acid
Formol
Hydroxy(oxo)methane
HCO2H (its condensed formula)
Acide formique (in French)
Ameisensäure (in German)
Ácido fórmico (in Spanish)
Acidum formicum (in Latin)
Acidum methanoicum
Carbonous acid
Hydroxy methanoic acid
Methylic alcohol
E236 (its European food additive number)
RCOOH (generic carboxylic acid formula)
EINECS 200-579-1 (European Inventory of Existing Commercial Chemical Substances number)
FEMA 2487 (Flavor and Extract Manufacturers Association number)
NSC 8957 (National Cancer Institute identifier)
HCO2OH
Acide formylique (in French)
Aminocarboxylic acid
Carboxylic acid C1
Ethanoic acid
Hydrogen formate
Methanoate
Methylic formic acid
Oxomethanol
RC(O)OH (generic carboxylic acid formula)
UN 1779 (United Nations identification number)
Formolene
Formylic alcoholate
Hydrogen methanoate
Hydroxy(oxo)methanol
Oxomethyl alcohol
Oxymethanol
RC(O)OH (generic carboxylic acid formula)
Methanoic acid solution
Methylformate
Monocarboxylic acid
R-COOH (generic carboxylic acid formula)
RCO2H (generic carboxylic acid formula)
Carboxymethanol
Carboxylic acid (methanoic acid)
Acid of ants
Carbonic acid
Ethylic formate
Formate
Formic alcohol
HCO2H (systematic name)
Hydrogen carboxylate
Hydroxy(oxo)methyl radical
Methyl carboxylate
Methanoic alcohol
Methanoic acid solution
Methylic acid
R-COOH (generic carboxylic acid formula)
Acidum formicum concentratum
Ameisengeist (in German)
Ant's vinegar
Ethanoic acid solution
HCOOH (chemical formula)
Hydrogen methanoate
Methanoic acid salt
RC(O)OH (generic carboxylic acid formula)
Acidum formicum dilutum
Formylic acid solution
HCO2H (IUPAC abbreviation)
Mierenzuur (in Dutch)
FRAGRANCE
FRAGRANCE Aroma compound An aroma compound, also known as an odorant, aroma, fragrance or flavor, is a chemical compound that has a smell or odor. For an individual chemical or class of chemical compounds to impart a smell or fragrance, it must be sufficiently volatile for transmission via the air to the olfactory system in the upper part of the nose. As examples, various fragrant fruits have diverse aroma compounds,[1] particularly strawberries which are commercially cultivated to have appealing aromas, and contain several hundred aroma compounds.[1][2] Generally, molecules meeting this specification have molecular weights of less than 310.[3] Flavors affect both the sense of taste and smell, whereas fragrances affect only smell. Flavors tend to be naturally occurring, and the term fragrances may also apply to synthetic compounds, such as those used in cosmetics.[4] Aroma compounds can be found in various foods, such as fruits and their peels, wine, spices, floral scent, perfumes, fragrance oils, and essential oils. For example, many form biochemically during the ripening of fruits and other crops.[1][5] Wines have more than 100 aromas that form as byproducts of fermentation.[6] Also, many of the aroma compounds play a significant role in the production of compounds used in the food service industry to flavor, improve, and generally increase the appeal of their products.[1] An odorizer may add a detectable odor to a dangerous odorless substance, like propane, natural gas, or hydrogen, as a safety measure. Alcohols Furaneol (strawberry) 1-Hexanol (herbaceous, woody) cis-3-Hexen-1-ol (fresh cut grass) Menthol (peppermint) Aldehydes High concentrations of aldehydes tend to be very pungent and overwhelming, but low concentrations can evoke a wide range of aromas. Acetaldehyde (ethereal) Hexanal (green, grassy) cis-3-Hexenal (green tomatoes) Furfural (burnt oats) Hexyl cinnamaldehyde Isovaleraldehyde – nutty, fruity, cocoa-like Anisic aldehyde – floral, sweet, hawthorn. It is a crucial component of chocolate, vanilla, strawberry, raspberry, apricot, and others. Cuminaldehyde (4-propan-2-ylbenzaldehyde) – Spicy, cumin-like, green Esters Fructone (fruity, apple-like) Ethyl methylphenylglycidate (Strawberry) alpha-Methylbenzyl acetate (Gardenia) Ketones Cyclopentadecanone (musk-ketone)[7] Dihydrojasmone (fruity woody floral) Oct-1-en-3-one (blood, metallic, mushroom-like)[8] 2-Acetyl-1-pyrroline (fresh bread, jasmine rice) 6-Acetyl-2,3,4,5-tetrahydropyridine (fresh bread, tortillas, popcorn) Lactones gamma-Decalactone intense peach flavor gamma-Nonalactone coconut odor, popular in suntan lotions delta-Octalactone creamy note Jasmine lactone powerful fatty-fruity peach and apricot Massoia lactone powerful creamy coconut Wine lactone sweet coconut odor Sotolon (maple syrup, curry, fenugreek) Thiols Main article: Thiol Thioacetone (2-propanethione) A lightly studied organosulfur. Its smell is so potent it can be detected several hundred meters downwind mere seconds after a container is opened. Allyl thiol (2-propenethiol; allyl mercaptan; CH2=CHCH2SH) (garlic volatiles and garlic breath)[9] (Methylthio)methanethiol (CH3SCH2SH), the "mouse thiol", found in mouse urine and functions as a semiochemical for female mice[10] Ethanethiol, commonly called ethyl mercaptan (added to propane or other liquefied-petroleum gases used as fuel gases) 2-Methyl-2-propanethiol, commonly called tert-butyl mercaptan, is added as a blend of other components to natural gas used as fuel gas. Butane-1-thiol, commonly called butyl mercaptan, is a chemical intermediate. Grapefruit mercaptan (grapefruit) Methanethiol, commonly called methyl mercaptan (after eating Asparagus) Furan-2-ylmethanethiol, also called furfuryl mercaptan (roasted coffee) Benzyl mercaptan (leek or garlic-like) Miscellaneous compounds Methylphosphine and dimethylphosphine (garlic-metallic, two of the most potent odorants known)[8] Phosphine (zinc phosphide poisoned bait) Diacetyl (butter flavor) Acetoin (butter flavor) Nerolin (orange flowers) Tetrahydrothiophene (added to natural gas) 2,4,6-Trichloroanisole (cork taint) Substituted pyrazines Aroma-compound receptors Animals that are capable of smell detect aroma compounds with their olfactory receptors. Olfactory receptors are cell-membrane receptors on the surface of sensory neurons in the olfactory system that detect airborne aroma compounds. Aroma compounds can then be identified by gas chromatography-olfactometry, which involves a human operator sniffing the GC effluent.[11] In mammals, olfactory receptors are expressed on the surface of the olfactory epithelium in the nasal cavity.[5] Safety and regulation Patch test In 2005–06, fragrance mix was the third-most-prevalent allergen in patch tests (11.5%).[12] 'Fragrance' was voted Allergen of the Year in 2007 by the American Contact Dermatitis Society. A recent academic study in the United States has shown that "34.7 % of the population reported health problems, such as migraine headaches and respiratory difficulties, when exposed to fragranced products".[13] The composition of fragrances is usually not disclosed in the label of the products, hiding the actual chemicals of the formula, which raises concerns among some consumers.[14] In the United States, this is because the law regulating cosmetics protects trade secrets.[15] In the United States, fragrances are regulated by the Food and Drug Administration if present in cosmetics or drugs, by the Consumer Products Safety Commission if present in consumer products.[15] No pre-market approval is required, except for drugs. Fragrances are also generally regulated by the Toxic Substances Control Act of 1976 that "grandfathered" existing chemicals without further review or testing and put the burden of proof that a new substance is not safe on the EPA. The EPA, however, does not conduct independent safety testing but relies on data provided by the manufacturer.[16] A 2019 study of the top-selling skin moisturizers found 45% of those marketed as "fragrance-free" contained fragrance.[17] List of chemicals used as fragrances In 2010, the International Fragrance Association published a list of 3,059 chemicals used in 2011 based on a voluntary survey of its members, identifying about 90% of the world's production volume of fragrances.[18] See also Flavour and Fragrance Journal Fragrances of the World Foodpairing Odor Odor detection threshold Olfaction Olfactory system Olfactory receptor Odorizer, a device for adding an odorant to gas flowing through a pipe Pheromone Aroma of wine Eau de toilette Across multiple research studies, chemicals used to make fragrances are classified as allergens, hormone disruptors, asthma triggers, neurotoxins & carcinogens. The punchline: fragrances are highly toxic. Fragrances commonly contain phthalates, which are chemicals that help the scents last longer. Health risks for phthalates are startling and include cancer, human reproductive and developmental toxicity, endocrine disruption, birth defects & respiratory problems. These toxic villains are very hard to avoid because manufacturers are not required to list them on ingredient labels. Fragrance chemicals, like other toxic chemicals, can pass from the skin and into the blood. Manufacturers are not required to list their fragrance ingredients on product labels. Often only one word, “fragrance”, is used on the label and can hide a cocktail of more than 100 toxic ingredients. This is because fragrances are considered to be “trade secrets”. The fragrance industry regulates itself, so that safety testing does not have to be confirmed by regulators before products are sold to consumers. So called “natural fragrances” can be just as toxic as synthetic fragrances. Whether it’s in a cleaning product, deodorant, shampoo, or laundry detergent, fragrance chemicals aren’t actually making your product perform better – they are just giving you that perception. We’ve been trained to think that clean has a smell, when in truth that’s not the case. Net, fragrances are linked to so many profound health risks that avoiding them is probably the #1 change you can make to reduce your family’s exposure to toxic chemicals. To avoid fragrances, the Environmental Working Group advises that consumers read the word “fragrance” or “parfum” and translate it to mean “hidden chemicals”. We believe the safest choice is to always choose fragrance-free products. But a couple of key tips you should keep in mind: Don’t be fooled by products labeled with “natural fragrance,” because there is no standard criteria for what these words mean. These can be just as un-safe as fragrances not described this way, so skip these products too. If you see the words “fragrance-free” or “unscented”, your Spidey senses should kick into action. You also have to check the ingredient list, because sometimes manufacturers use masking fragrances to cover the chemical smell of their products. “Fragrance” or “parfum” on an ingredients list is a term used for a collection of chemicals that gives a scent. There are over 3000 chemicals that can be used to make up fragrances. As defined by the American FDA, fragrance is a combination of chemicals that gives each perfume or cologne (including those used in other products) it’s distinct scent. Here’s the catch – as fragrance can be considered a proprietary blend, manufacturers are not obligated to disclose the chemicals used in that blend. Many of these unlisted ingredients have not been tested for toxicity, either alone or in combination. Fragrance ingredients may be derived from petroleum or natural raw materials. In addition to the “scent” chemicals used to create a fragrance, the mixture also requires solvents, stabilizers, UV-absorbers, preservatives and dyes. FOUND IN sunscreen moisturizer shampoo conditioner soap and body wash deodorant make up toner serums exfoliating scrubs perfume laundry detergent & softeners cleaning products WHAT TO LOOK FOR Fragrance, perfume, parfum, essential oil blend, aroma RISKS Sensitivities: A random sampling of US residents from a 2016 study noted that over 99% of participants are exposed to fragranced products at least once a week. Participants of this study also reported an extensive list of health concerns when exposed to fragrance, including migraines, asthma, gastrointestinal issues, and cardiovascular problems (1). Bio Accumulation: Synthetic musks used in fragrances are of environmental concern. Several compounds found in musk build up in the fatty tissue of aquatic animals. Heightened levels of synthetic musk have been found in fish within the Great Lakes, and in sediment. Synthetic musks have been categorized as toxic and bio-accumulative by Environment Canada. Unlisted Fragrance Ingredients and Their Risks: Acetaldehyde: suspected toxicity to nervous and respiratory systems (2). Benzophenone: endocrine disruption and organ toxicity (3); tumours (4) Butylated hydroxyanisole (BHA): Endocrine distruption (5); carcinogen (6) Butylated hydroxytoluene (BHT): skin and eye irritation, affects growth rate and liver (7); respiratory irritant (8) Benzyl Salicylate: allergen and potential endocrine disruptor (9)(10) Benzyl Benzoate: skin and eye irritant (11) Butoxyethanol: skin, eye, nose and throat irritant. Exposure ca lead to blood in urine, vomiting, nausea, and damage to kidneys, liver, lymphoid system, nervous system, respiratory system, and blood cells (12) Butylphenyl methylpropional: skin sensitization (13). Chloromethane (methyl chloride): affects nervous system, liver, kidney and skin (14); developmentally toxic (15) Dichloromethane (methylene chloride): linked to mammary gland tumours in experimental animals (16); may be human carcinogen (17) Diethyl phthalate (DEP): irritant of eyes, skin, and respiratory tract; potential endocrine disruptor (18) (19) Essential Oil Mixtures: Despite the ingredients being of natural origin, some essential oils are allergens (20); essential oils may contain ingredients such as pulegone or methyleugenol that may be carcinogenic and alter endocrine function (21)(22)(23) Eugenyl methyl ether (Methyleugenol): Affects multiple endocrine systems (24); causes mammary gland tumours in experimental animals (25); possible human carcinogen (26) Formaldehyde: known human carcinogen (27) MEA, DEA, TEA – ethanolamines: When ethanolamines are used in the same products as certain preservatives that break down into nitrogen, the can turn into nitrosamines. Nitrosimines is a group of chemicals which has been listed as possible and known carcinogens (28) Methanol: Developmental toxicant (29) Oxybenzone (BP-3): Possible endocrine disruptor (30); Oxybenzone can accumulate in the blood, kidneys and liver, and may be toxic to liver cells (31) Propyl paraben (Propyl p-hydroxybenzoate): Possible endocrine disruptor (32). Resorcinol: Resorcinol adversely affects cardiovascular and nervous system, while changing liver, kidney, and spleen function (33); possible endocrine disruptor (34). Styrene: When ingested orally, styrene is toxic to red blood cells and liver, and toxic to central nervous system when inhaled (35) Synthetic Musks (Tonalide , Galaxolide, Musk Ketone, Musk Xylene): Highly bioaccumulative and have been found in breast milk, body fat and cord blood of newborn babies (36)(37)(38)(39); endocrine disruptor (40). Titanium dioxide (TiO2): Damages respiratory system and may be a carcinogen (41) 1,4-Dioxane: suspected to cause cancer and birth defects (42) Ethylbenzene: Classified as possible carcinogen and cancer causing (43) Vinyl acetate: Possible carcinogen (44); inhalation may cause eye irritation and upper respiratory tract irritation (45)
FRESCOLAT MGA
Frescolat MGA provides relief solution for the skin.
Frescolat MGA gives immediate, strong and long-lasting cooling effect.


CAS Number: 63187-91-7
EC Number: 408-200-3
INCI Name: Menthone Glycerin Acetal
Molecular Formula: C13H24O3



SYNONYMS:
1,4-Dioxaspiro[4.5]decane-2-methanol,9-methyl-6-(1-methylethyl)-, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane-2-methanol, Frescolat MGA, Menthone glycerin acetal, Menthone glyceryl ketal, 6-Isopropyl-9-methyl-1,4-dioxaspiro[4,5]decane-2-methanol, (6-Isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl)methanol, Fema Gras 3808, Menthone glycerine acetal, (9-Methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol, [9-Methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol, Menthone 1,2-glycerol ketal, FRESCOLAT, TYPE MGA RACEMIC, 63187-91-7, Menthone 1,2-glycerol ketal, Frescolat MGA, 6-Isopropyl-9-methyl-1,4-dioxaspiro[4.5]decane-2-methanol, 1,4-Dioxaspiro[4.5]decane-2-methanol, 9-methyl-6-(1-methylethyl)-, Menthone glycerin acetal, Menthone 1,2-glyceryl ketal, 6-Isopropyl-9-methyl-1,4-dioxaspiro(4.5)decane-2-methanol, 7QQ1EE6RCP, (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol, (6-isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl)methanol, Menthone 1,2-glycerol ketal, (+/-)-, 1,4-Dioxaspiro(4.5)decane-2-methanol, 9-methyl-6-(1-methylethyl)-, [9-methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro(4.5)decane-2-methanol, menthone glyceryl ketal, UNII-7QQ1EE6RCP, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane-2-methanol, Menthoneglycerinacetal, starbld0009751, EC 408-200-3, SCHEMBL169625, GTPL2465, FEMA NO. 3808, FEMA 3807, FEMA 3808, DTXSID20866983, CHEBI:169866, ZBJCYZPANVLBRK-UHFFFAOYSA-N, FRESCOLAT, TYPE MGA RACEMIC, (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-2-yl)methanol, (+/-)-menthone 1,2-glycerol ketal, 2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro(4.5)decane, AKOS015908506, AC-9867, DL-MENTHONE 1,2-GLYCEROL KETAL, CS-0454364, NS00003186, E79266, D,L-MENTHONE 1,2-GLYCEROL KETAL [FHFI], DL-MENTHONE (+/-)-1,2-GLYCEROL KETAL, Q27077744, 6-Isopropyl-9-methyl-1,4-dioxaspiro(4,5)decane-2-methanol, 2-Hydroxymethyl-6-isopropyl-9-methyl-1,4-dioxaspiro[4.5]decane, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane-2-methanol, 9CI



Frescolat MGA belongs to the class of organic compounds known as menthane monoterpenoids.
These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone.
P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively.


The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes.
Frescolat MGA is Menthone Glycerin Acetal.
Frescolat MGA is a patented, menthol-free cooling agent.


Frescolat MGA is a natural extract.
Frescolat MGA provides relief solution for the skin.
Frescolat MGA gives immediate, strong and long-lasting cooling effect.


Optimal for pH of Frescolat MGA is 6.5-12.
Frescolat MGA (INCI: Menthone Glycerin Acetal) is the solution to bring freshness to alkaline formulations such as depilatories and deodorants.
Frescolat MGA (#F-165) is a highly pure, synthetic, and biologically active compound.


Frescolat MGA is used coolant; safe and technologically advanced alternative to menthol, optimal for high pH values ​​>8 (soap, depilatory products).
Dosage of Frescolat MGA is 0.1-3%.
Menthyl 1,2-propanetriol, Frescolat MGA is on the EFFA list of food flavoring ingredients authorized for use in Europe, and its FEMA numbers are 3807 and 3808, respectively.


Frescolat MGA is a highly pure, synthetic, and biologically active compound.
Frescolat MGA is a p-menthane monoterpenoid.


Frescolat MGA is a TRPM8 channel activator and cooling agent.
Frescolat MGA activates mouse TRPM8 channels with EC50 of 4.8 muM.
Frescolat MGA is Colorless viscous liquid.


Frescolat MGA is a clear, colorless, pale, viscous liquid and creates a physiological cooling sensation on the skin or mucosa.
Frescolat MGA is prepared by acetalization of l-menthone with glycerine.
Frescolat MGA has a mint, menthol taste.


Frescolat MGA is a clear colourless viscous liquid.
Frescolat MGA is a p-menthane monoterpenoid.
Frescolat MGA, also known as menthone glycerin acetal, is a synthetic compound widely used as a cooling agent.


Frescolat MGA is a highly pure, synthetic, and biologically active compound.
Frescolat MGA is a colorless liquid that provides a strong, long-lasting sensation of freshness and cooling.
Frescolat MGA is particularly valued for its non-irritating properties, low odor, and suitability for various formulations, including oral care products .


Frescolat MGA is an excellent and more effective alternative to Menthol as it is non-irritating and compatabile with a wide pH (6.5 - 12).
Frescolat MGA has low odour and is in a clear liquid.
Frescolat MGA quickly provides a cooling and icing effect to the skin.


Frescolat MGA has proven efficacy to bring up to 25 minutes colling relief to the skin.
Frescolat MGA is a colorless liquid used as an active cooling agent.
Frescolat MGA creates a strong, long-lasting sensation of freshness and cooling.


Benefits of Frescolat MGA include signal for efficacy, non-irritating, optimal for alkalin formulations, low odor, clear liquid and suitable for oral care (FEMA 3807)
Frescolat MGA acts as a gentle algefacient.
Frescolat MGA shows stronger cool feeling and more mildness as compared with lactic acid menthyl ester.


Frescolat MGA does not cause irritation to the skin.
Frescolat MGA exhibits good combinative- and synergistic action.
Frescolat MGA is widely suitable for personal care products such as fragrances, shampoos, bath foam and shaving products.


Frescolat MGA also works as a cool stabilizer of mint flavor.
Frescolat MGA is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.
Frescolat MGA is a colorless liquid used as an active cooling agent in alkalin formulations.


Frescolat MGA will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat MGA is designed for bar soap applications.
Frescolat MGA is a colourless liquid used as an active cooling agent.


Frescolat MGA creates a strong, long-lasting sensation of skin icing, skin freshness and skin cooling.
Frescolat MGA has proven efficacy of up to 25 minutes.


Frescolat MGA is a colorless liquid used as an active cooling agent.
Frescolat MGA creates a strong, long-lasting sensation of freshness and cooling.



USES and APPLICATIONS of FRESCOLAT MGA:
Frescolat MGA is used in oral care applications.
Frescolat MGA has an immediate and long-lasting cooling effect.
Frescolat MGA provides a long-lasting cooling effect and acts as a relief player in hair treatments.


A large number of publications have reported its application in food flavor formulations, and in most cases Frescolat MGA is used in combination with other refrigerating agents.
Frescolat MGA is a cooling agent used in various personal care and cosmetic products.


Frescolat MGA provides a refreshing and cooling sensation when applied to the skin or hair.
Frescolat MGA is used for adding fragrance, and to leave the skin feeling refreshed and cool.


Frescolat MGA is a menthol derivative that can be naturally obtained or synthetically manufactured.
Frescolat MGA is mainly used to create a cooling effect in cosmetic preparations used on the skin.


Frescolat MGA is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Frescolat MGA is used in the following products: biocides (e.g. disinfectants, pest control products), washing & cleaning products, air care products, polishes and waxes and cosmetics and personal care products.


Other release to the environment of Frescolat MGA is likely to occur from: indoor use as processing aid and outdoor use as processing aid.
Other release to the environment of Frescolat MGA is likely to occur from: indoor use as processing aid.
Release to the environment of Frescolat MGA can occur from industrial use: formulation of mixtures.


Release to the environment of Frescolat MGA can occur from industrial use: in processing aids at industrial sites.
Release to the environment of Frescolat MGA can occur from industrial use: manufacturing of the substance.
Frescolat MGA is a colourless liquid used as an active cooling agent.


Frescolat MGA creates a strong, long-lasting sensation of skin icing, skin freshness and skin cooling.
Frescolat MGA has proven efficacy of up to 25 minutes
Frescolat MGA will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.


Frescolat MGA is designed for bar soap applications.
The cooling effects of Frescolat MGA can be used to negate the irritancy of products with a low pH or containing ingredients that can cause short term irritation as the icing effect will bring greater comfort to users.


Frescolat MGA shows stronger cool feeling and more mildness as compared with lactic acid menthyl ester.
Frescolat MGA does not cause irritation to the skin.


Frescolat MGA exhibits good combinative- and synergistic action.
Frescolat MGA is widely suitable for personal care products such as fragrances, shampoos, bath foam and shaving products.


-In the industry, Frescolat MGA is used in the formulation of personal care products, such as toothpaste, mouthwash, and skincare products.
Its ability to provide a long-lasting cooling sensation makes Frescolat MGA a popular ingredient in these products


-Scientific Research Applications of Frescolat MGA:
Frescolat MGA has a wide range of scientific research applications.
In chemistry, Frescolat MGA is used as a model compound to study acetalization reactions and the stability of acetal bonds.
In biology, Frescolat MGA is used to investigate the effects of cooling agents on cellular processes and temperature-sensitive ion channels .

In medicine, Frescolat MGA is explored for its potential therapeutic applications, particularly in the development of topical formulations for pain relief and skin conditions.
Its cooling properties make Frescolat MGA an attractive candidate for products designed to provide relief from itching, burning, and other discomforts.



CLAIMS OF FRESCOLAT MGA:
*Cooling Agents
*long-lasting



ALTERNATIVE PARENTS OF FRESCOLAT MGA:
*Ketals
*1,3-dioxolanes
*Oxacyclic compounds
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS OF FRESCOLAT MGA:
*P-menthane monoterpenoid
*Ketal
*Meta-dioxolane
*Oxacycle
*Organoheterocyclic compound
*Acetal
*Organic oxygen compound
*Hydrocarbon derivative
*Primary alcohol
*Organooxygen compound
*Alcohol
*Aliphatic heteropolycyclic compound



MECHANISM OF ACTION OF FRESCOLAT MGA:
Frescolat MGA exerts its cooling effects by activating the transient receptor potential melastatin 8 (TRPM8) channels.
These channels are temperature-sensitive ion channels that are activated by cool temperatures and chemical agonists like menthol and icilin .

Upon activation, TRPM8 channels allow the influx of calcium ions into the cells, leading to the sensation of cooling.
This mechanism is similar to that of menthol, but Frescolat MGA is designed to provide a longer-lasting and more intense cooling effect .



PREPARATION METHODS OF FRESCOLAT MGA:
Frescolat MGA is synthesized through the acetalization of menthone with glycerin.
The reaction typically involves the use of an acid catalyst to facilitate the formation of the acetal bond between menthone and glycerin.

The reaction conditions are carefully controlled to ensure high yield and purity of the final product .
In industrial production, the process is scaled up to produce large quantities of Frescolat MGA.
The reaction is carried out in large reactors, and Frescolat MGA is purified through distillation and other separation techniques to remove any impurities .



CHEMICAL REACTIONS ANALYSIS OF FRESCOLAT MGA:
Frescolat MGA primarily undergoes substitution reactions due to the presence of the acetal functional group.
Common reagents used in these reactions include acids and bases, which can catalyze the hydrolysis of the acetal bond, leading to the formation of menthone and glycerin.

The major products formed from these reactions are menthone and glycerin.
These reactions are typically carried out under mild conditions to prevent the degradation of Frescolat MGA .



COMPARISON WITH SIMILAR COMPOUNDS OF FRESCOLAT MGA:
Frescolat MGA is often compared to other cooling agents, such as menthol and menthyl lactate.
While menthol is the most well-known cooling agent, Frescolat MGA has some disadvantages, such as a strong odor and potential irritation at higher concentrations .

Frescolat MGA, on the other hand, is designed to overcome these limitations.
Frescolat MGA has a lower odor and is less irritating, making it suitable for a wider range of applications.
Additionally, Frescolat MGA provides a longer-lasting cooling effect compared to menthol .



SIMILAR COMPOUNDS INCLUDE:
*Menthol
*Menthyl lactate
*Icilin
Each of these compounds has unique properties and applications, but Frescolat MGA stands out for its combination of strong cooling effect, low odor, and non-irritating properties



WHAT DOES FRESCOLAT MGA DO IN A FORMULATION?
*Refreshing



FUNCTIONS OF FRESCOLAT MGA IN COSMETIC PRODUCTS:
*REFRESHING
Frescolat MGA imparts a pleasant freshness to the skin



HOW TO USE FRESCOLAT MGA:
Frescolat MGA is alcohol soluble, Glycol soluble and Oil Soluble.



USAGE AMOUNT OF FRESCOLAT MGA:
Frescolat MGA should be used between 0.1% and 2%.



PRODUCTS TO USE IN FRESCOLAT MGA:
Frescolat MGA is perfect for use in products where you are looking for an instant skin icing effect such as Shower Gel, Shampoo, Relief Balms, Depilatory Products, Hair Relaxaer, Shaving Foam.
Research has shown that 65% of Consumers are looking for products with a very strong feeling of freshness and 88% of consumers believe that coolness calms irritation.
66% of consumers feel that a product is working if they have a cooling effect upon application.



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT MGA:
Molecular Weight:228.33
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:228.17254462
Monoisotopic Mass:228.17254462
Topological Polar Surface Area:38.7
Heavy Atom Count:16
Complexity:241
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1

Compound Is Canonicalized:Yes
IUPAC Name: (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol
InChI: InChI=1S/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3
InChI Key: ZBJCYZPANVLBRK-UHFFFAOYSA-N
Canonical SMILES: CC1CCC(C2(C1)OCC(O2)CO)C(C)C
Molecular Formula: C13H24O3
DSSTOX Substance ID: DTXSID20866983
Molecular Weight: 228.33 g/mol
Physical Description: clear colourless viscous liquid
Boiling Point: 322.00 to 323.00 °C @ 760.00 mm Hg

Solubility: soluble in water, olive oil <15% and almond oil 1% w/w
Density: 1.0306, 1.0308
CAS RN: 63187-91-7
Formula: C13H24O3
InChI: InChI=1S/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3
InChI Key: InChIKey=ZBJCYZPANVLBRK-UHFFFAOYSA-N
SMILES: OCC1OC2(OC1)CC(C)CCC2C(C)C
Molecular Weight: 228.33 g/mol
XLogP3-AA: 2.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3

Rotatable Bond Count: 2
Exact Mass: 228.17254462 g/mol
Monoisotopic Mass: 228.17254462 g/mol
Topological Polar Surface Area: 38.7 Ų
Heavy Atom Count: 16
Formal Charge: 0
Complexity: 241
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 4
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0

Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Weight: 228.33
Exact Mass: 228.33
EC Number: 408-200-3
UNII: 7QQ1EE6RCP
HS Code: 2932999099
Characteristics:
PSA: 38.7
XLogP3: 2.97
Appearance: clear colourless viscous liquid

Density: 1.0±0.1 g/cm³
Boiling Point: 148-152 °C @ Press: 14 Torr
Flash Point: 159.7±4.7 °C
Refractive Index: 1.489
Water Solubility: 27.28 mg/L @ 25 °C (est)
soluble in water, olive oil <15% and almond oil 1% w/w
CAS No.: 63187-91-7
Chemical Name: Frescolat MGA (Menthone Glyceryl Acetal)
Synonyms: Frescolat MGA (Menthone Glyceryl Acetal)
CB Number: CB79911803
Display Name: 2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane
EC Number: 408-200-3
EC Name: 2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane

CAS Number: 63187-91-7
Molecular Formula: C13H24O3
IUPAC Name: [9-methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol
Chemical Formula: C13H24O3
Average Molecular Weight: 228.3279
Monoisotopic Molecular Weight: 228.172544634
IUPAC Name: [9-methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol
Traditional Name: {6-isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl}methanol
CAS Registry Number: 63187-91-7
SMILES: CC(C)C1CCC(C)CC11OCC(CO)O1
InChI Identifier: InChI=1S/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3
InChI Key: ZBJCYZPANVLBRK-UHFFFAOYSA-N



FIRST AID MEASURES of FRESCOLAT MGA:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT MGA:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT MGA:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT MGA:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT MGA:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT MGA:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


FRESCOLAT MGA PLUS
Frescolat MGA Plus is a colorless liquid used as an active cooling agent.
Frescolat MGA Plus creates a strong, long-lasting sensation of freshness and cooling.


CAS Number: 63187-91-7
EC Number: 408-200-3
Chem/IUPAC Name: 1,4-Dioxaspiro[4.5]decane-2-methanol, 9-methyl-6-(1-methylethyl)-; Menthone 1,2-glycerol ketal
INCI Name: Menthone Glycerin Acetal (and) Menthol



SYNONYMS:
1,4-Dioxaspiro[4.5]decane-2-methanol,9-methyl-6-(1-methylethyl)-, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane-2-methanol, Frescolat MGA, Menthone glycerin acetal, Menthone glyceryl ketal, 6-Isopropyl-9-methyl-1,4-dioxaspiro[4,5]decane-2-methanol, (6-Isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl)methanol, Fema Gras 3808, Menthone glycerine acetal, (9-Methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol, [9-Methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol, Menthone 1,2-glycerol ketal, FRESCOLAT, TYPE MGA RACEMIC, 63187-91-7, Menthone 1,2-glycerol ketal, Frescolat MGA, 6-Isopropyl-9-methyl-1,4-dioxaspiro[4.5]decane-2-methanol, 1,4-Dioxaspiro[4.5]decane-2-methanol, 9-methyl-6-(1-methylethyl)-, Menthone glycerin acetal, Menthone 1,2-glyceryl ketal, 6-Isopropyl-9-methyl-1,4-dioxaspiro(4.5)decane-2-methanol, 7QQ1EE6RCP, (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol, (6-isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl)methanol, Menthone 1,2-glycerol ketal, (+/-)-, 1,4-Dioxaspiro(4.5)decane-2-methanol, 9-methyl-6-(1-methylethyl)-, [9-methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro(4.5)decane-2-methanol, menthone glyceryl ketal, UNII-7QQ1EE6RCP, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane-2-methanol, Menthoneglycerinacetal, starbld0009751, EC 408-200-3, SCHEMBL169625, GTPL2465, FEMA NO. 3808, FEMA 3807, FEMA 3808, DTXSID20866983, CHEBI:169866, ZBJCYZPANVLBRK-UHFFFAOYSA-N, FRESCOLAT, TYPE MGA RACEMIC, (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-2-yl)methanol, (+/-)-menthone 1,2-glycerol ketal, 2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro(4.5)decane, AKOS015908506, AC-9867, DL-MENTHONE 1,2-GLYCEROL KETAL, CS-0454364, NS00003186, E79266, D,L-MENTHONE 1,2-GLYCEROL KETAL [FHFI], DL-MENTHONE (+/-)-1,2-GLYCEROL KETAL, Q27077744, 6-Isopropyl-9-methyl-1,4-dioxaspiro(4,5)decane-2-methanol, 2-Hydroxymethyl-6-isopropyl-9-methyl-1,4-dioxaspiro[4.5]decane, 9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane-2-methanol, 9CI



Frescolat MGA Plus is an excellent and more effective alternative to Menthol as it is non-irritating and compatabile with a wide pH (6.5 - 12).
Frescolat MGA Plus has low odour and is in a clear liquid.
Frescolat MGA Plus quickly provides a cooling and icing effect to the skin.


Frescolat MGA Plus has proven efficacy to bring up to 25 minutes colling relief to the skin.
Frescolat MGA Plus is a colorless liquid used as an active cooling agent.
Frescolat MGA Plus creates a strong, long-lasting sensation of freshness and cooling.


Benefits of Frescolat MGA Plus include signal for efficacy, non-irritating, optimal for alkalin formulations, low odor, clear liquid and suitable for oral care (FEMA 3807)
Frescolat MGA Plus acts as a gentle algefacient.
Frescolat MGA Plus shows stronger cool feeling and more mildness as compared with lactic acid menthyl ester.


Frescolat MGA Plus does not cause irritation to the skin.
Frescolat MGA Plus provides relief solution for the skin.
Frescolat MGA Plus gives immediate, strong and long-lasting cooling effect.


Frescolat MGA Plus exhibits good combinative- and synergistic action.
Frescolat MGA Plus is widely suitable for personal care products such as fragrances, shampoos, bath foam and shaving products.


Frescolat MGA Plus also works as a cool stabilizer of mint flavor.
Frescolat MGA Plus is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.
Frescolat MGA Plus is a colorless liquid used as an active cooling agent in alkalin formulations.


Frescolat MGA Plus will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat MGA Plus is designed for bar soap applications.
Frescolat MGA Plus is a colourless liquid used as an active cooling agent.


Frescolat MGA Plus creates a strong, long-lasting sensation of skin icing, skin freshness and skin cooling.
Frescolat MGA Plus has proven efficacy of up to 25 minutes.


Frescolat MGA Plus belongs to the class of organic compounds known as menthane monoterpenoids.
These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone.
P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively.


The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes.
Frescolat MGA Plus is Menthone Glycerin Acetal.
Frescolat MGA Plus is a patented, menthol-free cooling agent.


Frescolat MGA Plus is a natural extract.
Frescolat MGA Plus provides relief solution for the skin.
Frescolat MGA Plus gives immediate, strong and long-lasting cooling effect.


Optimal for pH of Frescolat MGA Plus is 6.5-12.
Frescolat MGA Plus (INCI: Menthone Glycerin Acetal) is the solution to bring freshness to alkaline formulations such as depilatories and deodorants.
Frescolat MGA Plus (#F-165) is a highly pure, synthetic, and biologically active compound.


Frescolat MGA Plus is used coolant; safe and technologically advanced alternative to menthol, optimal for high pH values >8 (soap, depilatory products).
Dosage of Frescolat MGA Plus is 0.1-3%.
Menthyl 1,2-propanetriol, Frescolat MGA Plus is on the EFFA list of food flavoring ingredients authorized for use in Europe, and its FEMA numbers are 3807 and 3808, respectively.


Frescolat MGA Plus is a highly pure, synthetic, and biologically active compound.
Frescolat MGA Plus is a p-menthane monoterpenoid.


Frescolat MGA Plus is a TRPM8 channel activator and cooling agent.
Frescolat MGA Plus activates mouse TRPM8 channels with EC50 of 4.8 muM.
Frescolat MGA Plus is Colorless viscous liquid.


Frescolat MGA Plus is a clear, colorless, pale, viscous liquid and creates a physiological cooling sensation on the skin or mucosa.
Frescolat MGA Plus is prepared by acetalization of l-menthone with glycerine.
Frescolat MGA Plus has a mint, menthol taste.


Frescolat MGA Plus is a clear colourless viscous liquid.
Frescolat MGA Plus is a p-menthane monoterpenoid.
Frescolat MGA Plus, also known as menthone glycerin acetal, is a synthetic compound widely used as a cooling agent.


Frescolat MGA Plus is a highly pure, synthetic, and biologically active compound.
Frescolat MGA Plus is a colorless liquid that provides a strong, long-lasting sensation of freshness and cooling.
Frescolat MGA Plus is particularly valued for its non-irritating properties, low odor, and suitability for various formulations, including oral care products .



USES and APPLICATIONS of FRESCOLAT MGA PLUS:
Frescolat MGA Plus is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Frescolat MGA Plus is used in the following products: biocides (e.g. disinfectants, pest control products), washing & cleaning products, air care products, polishes and waxes and cosmetics and personal care products.


Other release to the environment of Frescolat MGA Plus is likely to occur from: indoor use as processing aid and outdoor use as processing aid.
Other release to the environment of Frescolat MGA Plus is likely to occur from: indoor use as processing aid.
Release to the environment of Frescolat MGA Plus can occur from industrial use: formulation of mixtures.


Release to the environment of Frescolat MGA Plus can occur from industrial use: in processing aids at industrial sites.
Release to the environment of Frescolat MGA Plus can occur from industrial use: manufacturing of the substance.
Frescolat MGA Plus is a colourless liquid used as an active cooling agent.


Frescolat MGA Plus creates a strong, long-lasting sensation of skin icing, skin freshness and skin cooling.
Frescolat MGA Plus has proven efficacy of up to 25 minutes
Frescolat MGA Plus will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.


Frescolat MGA Plus is designed for bar soap applications.
The cooling effects of Frescolat MGA Plus can be used to negate the irritancy of products with a low pH or containing ingredients that can cause short term irritation as the icing effect will bring greater comfort to users.


Frescolat MGA Plus shows stronger cool feeling and more mildness as compared with lactic acid menthyl ester.
Frescolat MGA Plus does not cause irritation to the skin.


Frescolat MGA Plus exhibits good combinative- and synergistic action.
Frescolat MGA Plus is widely suitable for personal care products such as fragrances, shampoos, bath foam and shaving products.


Frescolat MGA Plus is used in oral care applications.
Frescolat MGA Plus has an immediate and long-lasting cooling effect.
Frescolat MGA Plus provides a long-lasting cooling effect and acts as a relief player in hair treatments.


A large number of publications have reported its application in food flavor formulations, and in most cases Frescolat MGA Plus is used in combination with other refrigerating agents.
Frescolat MGA Plus is a cooling agent used in various personal care and cosmetic products.


Frescolat MGA Plus provides a refreshing and cooling sensation when applied to the skin or hair.
Frescolat MGA Plus is used for adding fragrance, and to leave the skin feeling refreshed and cool.


Frescolat MGA Plus is a menthol derivative that can be naturally obtained or synthetically manufactured.
Frescolat MGA Plus is mainly used to create a cooling effect in cosmetic preparations used on the skin.


-In the industry, Frescolat MGA Plus is used in the formulation of personal care products, such as toothpaste, mouthwash, and skincare products.
Its ability to provide a long-lasting cooling sensation makes Frescolat MGA Plus a popular ingredient in these products


-Scientific Research Applications of Frescolat MGA Plus:
Frescolat MGA Plus has a wide range of scientific research applications.
In chemistry, Frescolat MGA Plus is used as a model compound to study acetalization reactions and the stability of acetal bonds.
In biology, Frescolat MGA Plus is used to investigate the effects of cooling agents on cellular processes and temperature-sensitive ion channels .

In medicine, Frescolat MGA Plus is explored for its potential therapeutic applications, particularly in the development of topical formulations for pain relief and skin conditions.
Its cooling properties make Frescolat MGA Plus an attractive candidate for products designed to provide relief from itching, burning, and other discomforts.



WHAT DOES FRESCOLAT MGA PLUS DO IN A FORMULATION?
*Refreshing



FUNCTIONS OF FRESCOLAT MGA PLUS IN COSMETIC PRODUCTS:
*REFRESHING
Frescolat MGA Plus imparts a pleasant freshness to the skin



HOW TO USE FRESCOLAT MGA PLUS:
Frescolat MGA Plus is alcohol soluble, Glycol soluble and Oil Soluble.



USAGE AMOUNT OF FRESCOLAT MGA PLUS:
Frescolat MGA Plus should be used between 0.1% and 2%.



PRODUCTS TO USE IN FRESCOLAT MGA PLUS:
Frescolat MGA Plus is perfect for use in products where you are looking for an instant skin icing effect such as Shower Gel, Shampoo, Relief Balms, Depilatory Products, Hair Relaxaer, Shaving Foam.
Research has shown that 65% of Consumers are looking for products with a very strong feeling of freshness and 88% of consumers believe that coolness calms irritation.
66% of consumers feel that a product is working if they have a cooling effect upon application.



CLAIMS OF FRESCOLAT MGA PLUS:
*Cooling Agents
*long-lasting



ALTERNATIVE PARENTS OF FRESCOLAT MGA PLUS:
*Ketals
*1,3-dioxolanes
*Oxacyclic compounds
*Primary alcohols
*Hydrocarbon derivatives



SUBSTITUENTS OF FRESCOLAT MGA PLUS:
*P-menthane monoterpenoid
*Ketal
*Meta-dioxolane
*Oxacycle
*Organoheterocyclic compound
*Acetal
*Organic oxygen compound
*Hydrocarbon derivative
*Primary alcohol
*Organooxygen compound
*Alcohol
*Aliphatic heteropolycyclic compound



MECHANISM OF ACTION OF FRESCOLAT MGA PLUS:
Frescolat MGA Plus exerts its cooling effects by activating the transient receptor potential melastatin 8 (TRPM8) channels.
These channels are temperature-sensitive ion channels that are activated by cool temperatures and chemical agonists like menthol and icilin .

Upon activation, TRPM8 channels allow the influx of calcium ions into the cells, leading to the sensation of cooling.
This mechanism is similar to that of menthol, but Frescolat MGA Plus is designed to provide a longer-lasting and more intense cooling effect .



PREPARATION METHODS OF FRESCOLAT MGA PLUS:
Frescolat MGA Plus is synthesized through the acetalization of menthone with glycerin.
The reaction typically involves the use of an acid catalyst to facilitate the formation of the acetal bond between menthone and glycerin.

The reaction conditions are carefully controlled to ensure high yield and purity of the final product .
In industrial production, the process is scaled up to produce large quantities of Frescolat MGA Plus.
The reaction is carried out in large reactors, and Frescolat MGA Plus is purified through distillation and other separation techniques to remove any impurities.



CHEMICAL REACTIONS ANALYSIS OF FRESCOLAT MGA PLUS:
Frescolat MGA Plus primarily undergoes substitution reactions due to the presence of the acetal functional group.
Common reagents used in these reactions include acids and bases, which can catalyze the hydrolysis of the acetal bond, leading to the formation of menthone and glycerin.

The major products formed from these reactions are menthone and glycerin.
These reactions are typically carried out under mild conditions to prevent the degradation of Frescolat MGA Plus .



COMPARISON WITH SIMILAR COMPOUNDS OF FRESCOLAT MGA PLUS:
Frescolat MGA Plus is often compared to other cooling agents, such as menthol and menthyl lactate.
While menthol is the most well-known cooling agent, Frescolat MGA Plus has some disadvantages, such as a strong odor and potential irritation at higher concentrations .

Frescolat MGA Plus, on the other hand, is designed to overcome these limitations.
Frescolat MGA Plus has a lower odor and is less irritating, making it suitable for a wider range of applications.
Additionally, Frescolat MGA Plus provides a longer-lasting cooling effect compared to menthol .



SIMILAR COMPOUNDS INCLUDE:
*Menthol
*Menthyl lactate
*Icilin
Each of these compounds has unique properties and applications, but Frescolat MGA Plus stands out for its combination of strong cooling effect, low odor, and non-irritating properties



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT MGA PLUS:
Molecular Weight:228.33
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:228.17254462
Monoisotopic Mass:228.17254462
Topological Polar Surface Area:38.7
Heavy Atom Count:16
Complexity:241
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1

Compound Is Canonicalized:Yes
IUPAC Name: (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol
InChI: InChI=1S/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3
InChI Key: ZBJCYZPANVLBRK-UHFFFAOYSA-N
Canonical SMILES: CC1CCC(C2(C1)OCC(O2)CO)C(C)C
Molecular Formula: C13H24O3
DSSTOX Substance ID: DTXSID20866983
Molecular Weight: 228.33 g/mol
Physical Description: clear colourless viscous liquid
Boiling Point: 322.00 to 323.00 °C @ 760.00 mm Hg

Solubility: soluble in water, olive oil <15% and almond oil 1% w/w
Density: 1.0306, 1.0308
CAS RN: 63187-91-7
Formula: C13H24O3
InChI: InChI=1S/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3
InChI Key: InChIKey=ZBJCYZPANVLBRK-UHFFFAOYSA-N
SMILES: OCC1OC2(OC1)CC(C)CCC2C(C)C
Molecular Weight: 228.33 g/mol
XLogP3-AA: 2.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3

Rotatable Bond Count: 2
Exact Mass: 228.17254462 g/mol
Monoisotopic Mass: 228.17254462 g/mol
Topological Polar Surface Area: 38.7 Ų
Heavy Atom Count: 16
Formal Charge: 0
Complexity: 241
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 4
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0

Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Weight: 228.33
Exact Mass: 228.33
EC Number: 408-200-3
UNII: 7QQ1EE6RCP
HS Code: 2932999099
Characteristics:
PSA: 38.7
XLogP3: 2.97
Appearance: clear colourless viscous liquid

Density: 1.0±0.1 g/cm³
Boiling Point: 148-152 °C @ Press: 14 Torr
Flash Point: 159.7±4.7 °C
Refractive Index: 1.489
Water Solubility: 27.28 mg/L @ 25 °C (est)
soluble in water, olive oil <15% and almond oil 1% w/w
CAS No.: 63187-91-7
Chemical Name: Frescolat MGA Plus (Menthone Glyceryl Acetal)
Synonyms: Frescolat MGA Plus (Menthone Glyceryl Acetal)
CB Number: CB79911803
Display Name: 2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane
EC Number: 408-200-3
EC Name: 2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane

CAS Number: 63187-91-7
Molecular Formula: C13H24O3
IUPAC Name: [9-methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol
Chemical Formula: C13H24O3
Average Molecular Weight: 228.3279
Monoisotopic Molecular Weight: 228.172544634
IUPAC Name: [9-methyl-6-(propan-2-yl)-1,4-dioxaspiro[4.5]decan-2-yl]methanol
Traditional Name: {6-isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl}methanol
CAS Registry Number: 63187-91-7
SMILES: CC(C)C1CCC(C)CC11OCC(CO)O1
InChI Identifier: InChI=1S/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3
InChI Key: ZBJCYZPANVLBRK-UHFFFAOYSA-N



FIRST AID MEASURES of FRESCOLAT MGA PLUS:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT MGA PLUS:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT MGA PLUS:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT MGA PLUS:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT MGA PLUS:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT MGA PLUS:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


FRESCOLAT ML
Frescolat ML is used in oral care applications.
Frescolat ML acts as a cooling agent.
Frescolat ML dissolves in perfume oils, cosmetic oils or glycol solvents.


CAS Number: 59259-38-0 / 17162-29-7
EC Number: 261-678-3
INCI Name: Menthyl Lactate
Chemical Composition: 5-methyl-2 (1-methyl ethyl) cyclohexyl-2 hydroxypropionate, l-menthyl lactate, lactic acid menthyl ester
Chem/IUPAC Name: [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate
Molecular Formula: C13H24O3



SYNONYMS:
(-)-menthyl lactate, MENTHYL LACTATE, frescolat ML, 59259-38-0, l-Menthyl lactate, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate, (R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-HYDROXYPROPANOATE, 185915-25-7, L-Menthyl lactate, >=97%, SCHEMBL320044, (-)-p-Menthan-3-yl lactate, GTPL2466, FEMA 3748, L-Menthyl lactate, >=97%, FG, AKOS015964086, AC-9866, Q2640813, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, AldrichCPR, 61597-98-6, l-Menthyl lactate, L-Menthyl l-lactate, L-Menthyl (S)-lactate, Menthyl lactate [Mart.], L-Menthyl lactate [FHFI], (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (S)-2-Hydroxypropionate, MENTHYL LACTATE, FEMA No. 3748, 2S-(1R,2S,5R)-menthyl lactate, Propanoic acid, 2-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S)-, (S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, 2BF9E65L7I, (-)-menthyl lactate, (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (S)-2-hydroxypropanoate, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl (2S)-2-hydroxypropanoate, UNII-2BF9E65L7I, 59259-38-0, EC 612-179-8, SCHEMBL111620, MENTHYL LACTATE, (-)-, MENTHYL LACTATE [WHO-DD], UJNOLBSYLSYIBM-NOOOWODRSA-N, DTXSID301036338, MFCD09037384, MFCD27977194, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-2-hydroxypropanoate, AKOS027430477, AS-56902, Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1R-(1alpha(S*),2beta,5alpha))-, CS-0154344, I0889, D91210, Q27254517, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (R)-2-Hydroxypropionate, (S)-2-Hydroxypropionic Acid (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl Ester, PROPANOIC ACID, 2-HYDROXY-, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, (1R-(1.ALPHA.(S*),2.BETA.,5.ALPHA.)), Propanoic acid,2-hydroxy-,5-methyl-2-(1-methylethyl)cyclohexyl ester, Lactic acid,p-menth-3-yl ester, 1-Methyl-4-isopropyl-3-(2-hydroxypropionate)cyclohexanol, p-Menthyl lactate, Menthyl lactate, Frescolate ML, Covafresh II, Koko ML, Frescolat ML 620105, 2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, Fema Gras 3748, 2-Hydroxypropanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester, 2-Hydroxy-propionic acid 2-isopropyl-5-methyl-cyclohexyl ester, Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, Lactic acid, p-menth-3-yl ester, 1-Methyl-4-isopropyl-3-(2-hydroxypropionate)cyclohexanol, 2-Hydroxy-propionic acid 2-isopropyl-5-methyl-cyclohexyl ester, 2-Hydroxypropanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester, 2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, Covafresh II, Fema Gras 3748, Fescolat MI Nat, Frescolat ML 620105, Frescolate ML, Koko ML, p-Menthyl lactate



Frescolat ML is Menthyl Lactate.
Frescolat ML acts as a cooling agent.
Frescolat ML dissolves in perfume oils, cosmetic oils or glycol solvents.


Frescolat ML is used in oral care applications.
Frescolat ML (INCI: Menthyl lactate), is a menthol derivative (menthol ester) capable of generating a mild and gentle cooling sensation on the skin.
Frescolat ML's use is now widespread in many applications (rinse-off and leave-on applications).


Well tolerated and completely odorless in formulation, Frescolat ML creates a freshness in perfect affinity with the skin.
Frescolat ML has been recently shown in an in vitro test that this range was helping to protect against the growth of bad bacteria in the intimate area.
This range is composed of a colourless to liquid (Frescolat ML) and a powdery crystalline form (Frescolat ML cryst new quality), as long as a natural one (Frescolat ML nat), which is 100% natural and Ecocert certified.


This range allows to answer to all formulation needs and sustainability requirements.
A long-lasting sensation of freshness is also a key parameter for the consumers
Frescolat ML is a cooling ingredient without menthol, optimal for pH values ​​4 – 8.


Dosage of Frescolat ML is 0.5-3%
Frescolat ML, in the EFFA list of permitted flavoring ingredients in Europe, has a FEMA number of 3748.
Frescolat ML is classified as a flavoring agent by FEMA despite its weak mint aroma and earthy taste.


Frescolat ML provides a lasting feeling of freshness in the mouth.
Frescolat ML is a colorless liquid to solid product. Frescolat ML provides a pleasant, long-lasting freshness and cooling effect on the skin—creating the sensation of freshness and coolness without employing alcohol or menthol.


Frescolat ML can be used as an active cosmetic ingredient and is safe to use and compatible with mucous membranes
Frescolat ML is a colourless liquid used as an active cooling agent.
Frescolat ML sensates, is cooling and refreshing, and is a signal for efficacy.


Frescolat ML is a menthol-free coolant that can be used in personal care applications with acidic to neutral pH levels.
Frescolat ML, a menthol derivative, has an excellent cooling effect and refreshing sensation.
Frescolat ML is a cooling agent for cosmetic products.


Frescolat ML is derived from menthol but is less likely to cause irritation than pure menthol but with a similar level of cooling effect.
Frescolat ML has a lower odor than Menthol.
Frescolat ML is in the form of a white crystalline powder.


Frescolat ML is soluble in water and alcohol-based solvents.
The usage rate varies between 0.1% and 2% depending on the effect of Frescolat ML and its interaction with other compounds.
Frescolat ML vs menthol: There is no substantiated, published research to back up the claim that this menthol derivative is less sensitizing than menthol.


Frescolat ML is a gentler variation of menthol.
The cooling effect of Frescolat ML is milder than that of pure menthol, but is much better tolerated by the skin.
Frescolat ML is an ester of menthol and lactic acid of natural origin.


The cooling effect of Frescolat ML on the skin can be increased by adding 5 - 10% alcohol.
The cooling effect of Frescolat ML depends on the dose, but also on the type of formulation.
Polar oils such as short-chain ester oils or MCT oils have a stronger effect than non-polar oils such as long-chain vegetable oils.


However, high doses of oils and waxes can significantly reduce the cooling effect.
One possibility is to pre-dissolve the raw material in perfume oils or fatty oils, as Frescolat ML is insoluble in water, and then add it to the formulation.


Frescolat ML should be added to the emulsion at around 40 °C.
Frescolat ML is one of the menthol related cooling agents.
Frescolat ML is formed from a combination of menthol and lactic acid.


Frescolat ML is generally produced in two different forms, one as a crystalline white colored powder and another in a fused material, with slight minty flavor.
Frescolat ML is a white crystalline powder used as an active cooling agent.


Frescolat ML is a milder form of Menthol.
Frescolat ML is a white crystalline powder used as an active cooling agent.
Frescolat ML is odorless and tasteless and is easy to use and easy to solubilize.


Frescolat ML is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML is a kind of mint derivatives, as the white needle crystal, almost no aroma, cool taste persistent, has a cooling effect, is the best substitute of mint, has many characteristics, such as long-term, insipidity, without excitant.


Frescolat ML can be first mixed with oil, essence, glycol, added to the emulsion at about 35 ℃ to 40 ℃, it is also possible cold working, of course.
Frescolat ML has a tonic and refreshing effect.
Frescolat ML is a large complex of cooling components provides an immediate toning and refreshing feeling on the skin, as well as a feeling of cleanliness.


Frescolat ML does not cause burning and does not affect the final aroma of the product.
Tanning products containing Frescolat ML provide a toning feeling on the skin in 80% of respondents, and 93% confirmed the feeling of incredible freshness.
Frescolat ML creates the sensation of freshness and coolness without employing alcohol or menthol.


Frescolat ML is coolant; a safe and technological alternative to menthol, natural.
Dosage of Frescolat ML is 0.5-3%
Frescolat ML acts as a cooling agent.


Frescolat ML provides a pleasant, intensive long-lasting freshness and cooling effect on the skin.
Frescolat ML creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML supports deodorant activity and decreases sweat odor.


Frescolat ML is safe to use and compatible with mucous membranes.
Frescolat ML is COSMOS, Ecocert approved and China compliant.
Frescolat ML is a COSMOS approved colorless liquid used as an active cooling agent.


Frescolat ML is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML is a solid cooling agent and fragrance component for cosmetics.
Frescolat ML is a derivative of menthol, but is milder and more compatible with the skin.


Melting point of Frescolat ML is >35°C.
Recommended use level of Frescolat ML is 0.1-3%.
Frescolat ML is an ester of natural menthol and lactic acid, a highly effective and widely colorless liquid mainly used as a cooling agent.


Frescolat ML provides a quick cooling and long-lasting refreshing feeling with a weak chamomile-minty odor.
Frescolat ML is a food-grade ingredient used as a flavoring agent.
Frescolat ML is an active cooling agent that provides a pleasant, intensive long-lasting freshness and cooling effect on the skin.


Frescolat ML is the ester (chemical derivative) of menthol and lactic acid used primarily as a masking or fragrant agent in skin care and hair care.
Frescolat ML may be synthetic, plant-derived or animal-derived.
Frescolat ML can take the form of white crystals or white powder when in its raw material state.


Cosmetic ingredient suppliers recommend using Frescolat ML in concentrations between 0.01-2.0%.
Frescolat ML is a cooling agent for cosmetic products.


Frescolat ML is derived from menthol but is less likely to cause irritation than pure menthol but with a similar level of cooling effect.
Frescolat ML has a lower odour than Menthol.
Frescolat ML supports deodorant activity and decreases sweat odor.



USES and APPLICATIONS of FRESCOLAT ML:
Frescolat ML can increase the viscosity of products that contain tensides.
Frescolat ML shows enhance effectiveness if rapid hydration of the skin, brought about by products like O/W emulsions and gels.
Frescolat ML's cooling effect reduced if high percentages of oil- or wax-based cosmetic components.


Frescolat ML provides a pleasant cooling and fresh effect without the need for employing alcohol.
Frescolat ML should be added to emulsions at a temperature of around 40°C.
Frescolat ML is a translucent solid used as an active cooling agent.


Frescolat ML can be used as a cooling agent for body care, aftershave lotions and creams, shampoos, and after sun product
Applications of Frescolat ML: Facial cleanser / Lotion, milky lotion, cream / Other skin care and body care / Shampoo / Conditioner, treatment / Other hair cosmetics.


This minty-smelling compound, Frescolat ML, has been used as an insect repellent and strong flavor.
Frescolat ML has a light fragrance and is stable over a wide range of pH values ​​(ML: pH 4-8), making it suitable for incorporation into a variety of products.


Frescolat ML has the potential to provide a refreshing and cooling sensation to the skin.
Frescolat ML helps reduce irritation by soothing the skin.
Frescolat ML helps keep microorganisms under control by preventing bacterial and fungal growth.


Frescolat ML masks unwanted odors or adds a pleasant scent to products.
Frescolat ML helps extend the shelf life of products by reducing microbial activity and preventing oxidation.
Frescolat ML can help to soothe skin irritation and calm the skin.


Frescolat ML also has mild exfoliating properties that can help remove dead skin cells and improve skin texture.
Due to its mint-like odour, Frescolat ML is also used in flavour (oral care) and fragrance applications.
Frescolat ML generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.


Frescolat ML is a white crystalline powder used as an active cooling agent.
Frescolat ML will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat ML is odorless and tasteless and is easy to use and easy to solubilize.


Fields of use of Frescolat ML: shampoo, Rinse/Treatment, styling, Cream/lotion/skin lotion, Cleansing (face wash/body/hands/makeup remover), and Base Makeup.
Recommended usage of Frescolat ML is 0.1 to 2.0%.


Frescolat ML generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.
Frescolat ML provides fast & mild refreshing sensation and body-responsive freshness reactivated with water (mimicking sweat).
Frescolat ML supports deodorant activity and decreases sweat odor by acting on the axillary microbiome.


Frescolat ML is used in oral care products.
Frescolat ML acts as a cooling agent.
Frescolat ML is used in oral hygiene products.


Frescolat ML is an instant yet mild cooling sensation, menthol-free, crystal form.
Optimal for pH of Frescolat ML is 4-7.
Frescolat ML is used cooling ingredient, does not contain menthol, optimal for pH values 4 – 8.


Dosage of Frescolat ML is 0.5-2%
Frescolat ML is a translucent solid used as an active cooling agent.
Frescolat ML is Menthyl Lactate.


Frescolat ML acts as a nature-identical, menthol-free cooling agent.
Frescolat ML is a white crystalline substance.
Frescolat ML is China compliant.


Frescolat ML is a white crystalline substance.
Frescolat ML can increase the viscosity of products that contain tensides.
Effectiveness enhanced if rapid hydration of the skin, brought about by products like O/W emulsions and gels.


Cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML can be used as an active ingredient in cooling gels, sports creams, after-sun care, shaving products and much more.
Frescolat ML provides a pleasant cooling and fresh effect.


Frescolat ML is used skin care (Facial care, Facial cleansing, Body care, Baby care) Toiletries (Shower, Bath, Oral care) Hair care (Shampoos, Conditioners, Styling) Sun care (Sun protection, After-sun, Self-tanning).


Frescolat ML creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML supports deodorant activity and decreases sweat odor.
Frescolat ML is safe to use and compatible with mucous membranes.


Frescolat ML is used in oral care, skin care, hair care, shower gels, after sun, deodorants and shaving preparations.
Frescolat ML is a COSMOS approved colorless liquid used as an active cooling agent.
Frescolat ML will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.


Frescolat ML is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML can increase the viscosity of products that contain tensides.
Frescolat ML is effectiveness enhanced if rapid hydration of the skin, brought about by products like O/W emulsions and gels.


Frescolat ML is cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML is used skin care (Facial care, Facial cleansing, Body care, Baby care) Toiletries (Shower, Bath, Oral care) Hair care (Shampoos, Conditioners, Styling) Sun care (Sun protection, After-sun, Self-tanning).


Frescolat ML is suggested flavouring applications: Peppermint, spearmint, chocolate and cherry.
Frescolat ML is used for external use only.
Frescolat ML is used all kinds of skin care products.


So, Frescolat ML is safe for the skin with several beneficial effects, including skin conditioning, wound healing accelerator, insect repellent, and UV protection.
However, Frescolat ML has mild action compared to menthol, which has irritation potential.


Thanks to the water-binding ability of the lactic acid part, Frescolat ML also acts like an NMF, promoting skin hydration.
In addition, Frescolat ML stimulates cell migration and improves skin renewal rate.
Frescolat ML is stable in a wide range of pH and is used in numerous skin, lip, and hair care formulations.


The sensory perception and responses shown by Frescolat ML may be incorporated in various products in cosmetics, such as sun care products, deodorants, shower gels, facial cleanser or foams and after shave preparations.
Much like menthol, Frescolat ML exhibits a minty smell and prompts a cooling effect when applied topically.


Frescolat ML is supposed to be less sensitizing than menthol, but there’s not enough substantiated, published research supporting this notion.
However, aromatic compounds, due to their volatile nature, can cause skin sensitivity and damage, even if you can’t see any visible markers of this.


Frescolat ML’s most used in lip care, particularly for lip-plumping products, but is also found in skin care, body care and hair care.
Frescolat ML provides a pleasant cooling and fresh effect.



USE AND BENEFITS OF FRESCOLAT ML:
Frescolat ML has a long-lasting and pleasant cooling effect.
When in certain preparations there are many ingredients with different fragrances and those may produce a final product with a weird smell, in that case, Frescolat ML can be used to mask original taste or fragrance and produce the uniform effect.
Frescolat ML has a refreshing effect as well, which can be helpful in powders, toothpaste, chewing gums and other oral care products.



FEATURES OF FRESCOLAT ML:
*Frescolat ML is an alcohol-soluble cooling agent (solid) with a light fragrance and excellent long-lasting cooling effect.
Fields of use of Frescolat ML: shampoo, Rinse/Treatment, styling, Cream/lotion/skin lotion, Cleansing (face wash/body/hands/makeup remover), and Base Makeup.

Frescolat ML (INCI: Menthyl Lactate), which was found to support deodorant activity.
Frescolat ML supports deodorant activity in two ways:

*reducing body odor:
limiting underarm sweat odor up to 48 hr by managing the formation of odorous sweat compounds and;
acting on the axillary microbiome management: decreasing sweat odor by reducing anaerobic bacteria development only.

*The active is available in three formats to fit a variety of formulation needs:
Frescolat ML, containing L-menthol and natural lactic acid; Frescolat ML Nat. as 100% natural menthyl lactate; and Frescolat ML Cryst. as crystalline menthyl lactate.



FRESCOLAT ML AT A GLANCE:
*Derivative of menthol
*Exhibits a light, minty scent
*Prompts a cool, tingling sensation when applied topically
*Can cause skin sensitization



CLAIMS OF FRESCOLAT ML:
*Cooling Agents
*fresh feeling/cooling effect
*long-lasting freshness



FEATURES OF FRESCOLAT ML:
A cooling agent, Frescolat ML, that is soluble in alcohol and has a mild fragrance and excellent long-lasting cooling effect (crystals that are easy to work with)



WHAT IS FRESCOLAT ML USED FOR?
Frescolat ML is an active cooling agent that gives the skin a pleasant, intense, and prolonged feeling of freshness on the skin.
In cosmetics and personal care products, Frescolat ML serves as a masking and refreshing ingredient.

Frescolat ML can be used to cover up the original fragrance when there are numerous ingredients in a preparation with varying fragrances that could result in an odd-smelling finished product.
Additionally, Frescolat ML has a cooling effect that is beneficial in powders, toothpaste, chewing gum, and other oral care products.



ORIGIN OF FRESCOLAT ML:
Menthol and lactic acid react to produce a mixture comprising Frescolat ML and one or more higher lactoyl esters of Frescolat ML.
Hydrolysis of the esterification mixture follows in the presence of an aqueous base under conditions effective to convert the higher lactoyl esters to Frescolat ML.



WHAT DOES FRESCOLAT ML DO IN A FORMULATION?
*Masking
*Refreshing



SAFETY PROFILE OF FRESCOLAT ML:
Frescolat ML has a score of 1 on the Environmental Working Group (EWG’s) skin-deep scale, indicating a low potential for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and use restrictions.

Frescolat ML was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety.
The data showed that Frescolat ML is not genotoxic nor does it have skin sensitization potential.

Frescolat ML was found not to be a - PBT (Persistent, Bioaccumulative, and Toxic) as per the IFRA (The International Fragrance Association) Environmental Standards, and its risk quotients.
The Expert Panel for Fragrance Safety concludes that Frescolat ML is safe based on the RIFM (Research Institute for Fragrance Materials) Criteria Document.



ALTERNATIVES OF FRESCOLAT ML:
*MENTHOL



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT ML:
Molecular Weight: 228.33 g/mol
XLogP3-AA: 3.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 228.17254462 g/mol
Monoisotopic Mass: 228.17254462 g/mol
Topological Polar Surface Area: 46.5 Ų
Heavy Atom Count: 16
Formal Charge: 0
Complexity: 237

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula: C13H24O3
Average Mass: 228.332
Monoisotopic Mass: 228.172545
Boiling Point: 297.71°C
Melting Point: 47.66°C
Solubility: Soluble in water

Product Name: Menthyl lactate
CAS No.: 17162-29-7
Molecular Formula: C13H24O3
InChIKeys: InChIKey=UJNOLBSYLSYIBM-UHFFFAOYSA-N
Molecular Weight: 228.32800
Exact Mass: 228.33
EC Number: 261-678-3
HScode: 2918110000
Categories: Synthetic Fragrances
PSA: 46.53000
XLogP3: 2.37120
Appearance: colourless liquid or white crystalline solid
with a weak chamomile or tobacco odour

Density: 0.99 g/cm3
Boiling Point: 304ºC at 760 mmHg
Flash Point: 116.0±13.2 °C
Refractive Index: 1.467
Vapor Pressure: 8.58E-05mmHg at 25°C
Molecular FormulaC13H24O3
Molecular Weight228.33
IUPAC Name(5-methyl-2-propan-2-ylcyclohexyl) 2-hydroxypropanoate
Boiling Point304.0±15.0°C at 760 Torr
Density0.99±0.1 g/cm3
InChI KeyUJNOLBSYLSYIBM-UHFFFAOYSA-N
InChIInChI=1S/C13H24O3/c1-8(2)11-6-5-9(3)7-12(11)16-13(15)10(4)14/h8-12,14H,5-7H2,1-4H3
Canonical SMILESCC1CCC(C(C1)OC(=O)C(C)O)C(C)C



FIRST AID MEASURES of FRESCOLAT ML:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT ML:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT ML:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT ML:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT ML:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT ML:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
FRESCOLAT ML CRYST
Frescolat ML Cryst is a white crystalline powder used as an active cooling agent.
Frescolat ML Cryst is odorless and tasteless and is easy to use and easy to solubilize.


CAS Number: 59259-38-0 / 17162-29-7
EC Number: 261-678-3
INCI Name: Menthyl Lactate
Chemical Composition: 5-methyl-2 (1-methyl ethyl) cyclohexyl-2 hydroxypropionate, l-menthyl lactate, lactic acid menthyl ester
Chem/IUPAC Name: [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate
Molecular Formula: C13H24O3



SYNONYMS:
Propanoic acid,2-hydroxy-,5-methyl-2-(1-methylethyl)cyclohexyl ester, Lactic acid,p-menth-3-yl ester, 1-Methyl-4-isopropyl-3-(2-hydroxypropionate)cyclohexanol, p-Menthyl lactate, Menthyl lactate, Frescolate ML, Covafresh II, Koko ML, Frescolat ML 620105, 2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, Fema Gras 3748, 2-Hydroxypropanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester, 2-Hydroxy-propionic acid 2-isopropyl-5-methyl-cyclohexyl ester, Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, Lactic acid, p-menth-3-yl ester, 1-Methyl-4-isopropyl-3-(2-hydroxypropionate)cyclohexanol, 2-Hydroxy-propionic acid 2-isopropyl-5-methyl-cyclohexyl ester, 2-Hydroxypropanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester, 2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, Covafresh II, Fema Gras 3748, Fescolat MI Nat, Frescolat ML 620105, Frescolate ML, Koko ML, p-Menthyl lactate, (-)-menthyl lactate, MENTHYL LACTATE, frescolat ML, 59259-38-0, l-Menthyl lactate, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate, (R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-HYDROXYPROPANOATE, 185915-25-7, L-Menthyl lactate, >=97%, SCHEMBL320044, (-)-p-Menthan-3-yl lactate, GTPL2466, FEMA 3748, L-Menthyl lactate, >=97%, FG, AKOS015964086, AC-9866, Q2640813, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, AldrichCPR, 61597-98-6, l-Menthyl lactate, L-Menthyl l-lactate, L-Menthyl (S)-lactate, Menthyl lactate [Mart.], L-Menthyl lactate [FHFI], (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (S)-2-Hydroxypropionate, MENTHYL LACTATE, FEMA No. 3748, 2S-(1R,2S,5R)-menthyl lactate, Propanoic acid, 2-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S)-, (S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, 2BF9E65L7I, (-)-menthyl lactate, (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (S)-2-hydroxypropanoate, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl (2S)-2-hydroxypropanoate, UNII-2BF9E65L7I, 59259-38-0, EC 612-179-8, SCHEMBL111620, MENTHYL LACTATE, (-)-, MENTHYL LACTATE [WHO-DD], UJNOLBSYLSYIBM-NOOOWODRSA-N, DTXSID301036338, MFCD09037384, MFCD27977194, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-2-hydroxypropanoate, AKOS027430477, AS-56902, Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1R-(1alpha(S*),2beta,5alpha))-, CS-0154344, I0889, D91210, Q27254517, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (R)-2-Hydroxypropionate, (S)-2-Hydroxypropionic Acid (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl Ester, PROPANOIC ACID, 2-HYDROXY-, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, (1R-(1.ALPHA.(S*),2.BETA.,5.ALPHA.))



Frescolat ML Cryst is a white crystalline powder used as an active cooling agent.
Frescolat ML Cryst is a kind of mint derivatives, as the white needle crystal, almost no aroma, cool taste persistent, has a cooling effect, is the best substitute of mint, has many characteristics, such as long-term, insipidity, without excitant.


Frescolat ML Cryst can be first mixed with oil, essence, glycol, added to the emulsion at about 35 ℃ to 40 ℃, it is also possible cold working, of course.
Frescolat ML Cryst is a large complex of cooling components provides an immediate toning and refreshing feeling on the skin, as well as a feeling of cleanliness.


Frescolat ML Cryst does not cause burning and does not affect the final aroma of the product.
Tanning products containing Frescolat ML Cryst provide a toning feeling on the skin in 80% of respondents, and 93% confirmed the feeling of incredible freshness.


Frescolat ML Cryst creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML Cryst supports deodorant activity and decreases sweat odor.
Frescolat ML Cryst has a tonic and refreshing effect.


Frescolat ML Cryst is coolant; a safe and technological alternative to menthol, natural.
Dosage of Frescolat ML Cryst is 0.5-3%
Frescolat ML Cryst acts as a cooling agent.


Frescolat ML Cryst provides a pleasant, intensive long-lasting freshness and cooling effect on the skin.
Frescolat ML Cryst creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML Cryst supports deodorant activity and decreases sweat odor.


Frescolat ML Cryst is safe to use and compatible with mucous membranes.
Frescolat ML Cryst is COSMOS, Ecocert approved and China compliant.
Frescolat ML Cryst is a COSMOS approved colorless liquid used as an active cooling agent.


Frescolat ML Cryst is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML Cryst is a solid cooling agent and fragrance component for cosmetics.
Frescolat ML Cryst is a derivative of menthol, but is milder and more compatible with the skin.


Melting point of Frescolat ML Cryst is >35°C.
Recommended use level of Frescolat ML Cryst is 0.1-3%.
Frescolat ML Cryst is an ester of natural menthol and lactic acid, a highly effective and widely colorless liquid mainly used as a cooling agent.


Frescolat ML Cryst provides a quick cooling and long-lasting refreshing feeling with a weak chamomile-minty odor.
Frescolat ML Cryst is a food-grade ingredient used as a flavoring agent.
Frescolat ML Cryst is an active cooling agent that provides a pleasant, intensive long-lasting freshness and cooling effect on the skin.


Frescolat ML Cryst is the ester (chemical derivative) of menthol and lactic acid used primarily as a masking or fragrant agent in skin care and hair care.
Frescolat ML Cryst may be synthetic, plant-derived or animal-derived.
Frescolat ML Cryst can take the form of white crystals or white powder when in its raw material state.


Cosmetic ingredient suppliers recommend using Frescolat ML Cryst in concentrations between 0.01-2.0%.
Frescolat ML Cryst is a cooling agent for cosmetic products.
Frescolat ML Cryst is derived from menthol but is less likely to cause irritation than pure menthol but with a similar level of cooling effect.


Frescolat ML Cryst is used in oral care applications.
Frescolat ML Cryst acts as a cooling agent.
Frescolat ML Cryst dissolves in perfume oils, cosmetic oils or glycol solvents.


Frescolat ML Cryst is Menthyl Lactate.
Frescolat ML Cryst acts as a cooling agent.
Frescolat ML Cryst dissolves in perfume oils, cosmetic oils or glycol solvents.


Frescolat ML Cryst is used in oral care applications.
Frescolat ML Cryst (INCI: Menthyl lactate), is a menthol derivative (menthol ester) capable of generating a mild and gentle cooling sensation on the skin.
Frescolat ML Cryst's use is now widespread in many applications (rinse-off and leave-on applications).


Well tolerated and completely odorless in formulation, Frescolat ML Cryst creates a freshness in perfect affinity with the skin.
Frescolat ML Cryst has been recently shown in an in vitro test that this range was helping to protect against the growth of bad bacteria in the intimate area.


This range is composed of a colourless to liquid (Frescolat ML Cryst) and a powdery crystalline form (Frescolat ML Cryst cryst new quality), as long as a natural one (Frescolat ML Cryst nat), which is 100% natural and Ecocert certified.


This range allows to answer to all formulation needs and sustainability requirements.
A long-lasting sensation of freshness is also a key parameter for the consumers
Frescolat ML Cryst is a cooling ingredient without menthol, optimal for pH values 4 – 8.


Dosage of Frescolat ML Cryst is 0.5-3%
Frescolat ML Cryst, in the EFFA list of permitted flavoring ingredients in Europe, has a FEMA number of 3748.
Frescolat ML Cryst is classified as a flavoring agent by FEMA despite its weak mint aroma and earthy taste.


Frescolat ML Cryst provides a lasting feeling of freshness in the mouth.
Frescolat ML Cryst is a colorless liquid to solid product. Frescolat ML Cryst provides a pleasant, long-lasting freshness and cooling effect on the skin—creating the sensation of freshness and coolness without employing alcohol or menthol.


Frescolat ML Cryst can be used as an active cosmetic ingredient and is safe to use and compatible with mucous membranes
Frescolat ML Cryst is a colourless liquid used as an active cooling agent.
Frescolat ML Cryst sensates, is cooling and refreshing, and is a signal for efficacy.


Frescolat ML Cryst is a menthol-free coolant that can be used in personal care applications with acidic to neutral pH levels.
Frescolat ML Cryst, a menthol derivative, has an excellent cooling effect and refreshing sensation.
Frescolat ML Cryst is a cooling agent for cosmetic products.


Frescolat ML Cryst is derived from menthol but is less likely to cause irritation than pure menthol but with a similar level of cooling effect.
Frescolat ML Cryst has a lower odor than Menthol.
Frescolat ML Cryst is in the form of a white crystalline powder.


Frescolat ML Cryst has a lower odour than Menthol.
Frescolat ML Cryst is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML Cryst is soluble in water and alcohol-based solvents.


The usage rate varies between 0.1% and 2% depending on the effect of Frescolat ML Cryst and its interaction with other compounds.
Frescolat ML Cryst vs menthol: There is no substantiated, published research to back up the claim that this menthol derivative is less sensitizing than menthol.


Frescolat ML Cryst is a gentler variation of menthol.
The cooling effect of Frescolat ML Cryst is milder than that of pure menthol, but is much better tolerated by the skin.
Frescolat ML Cryst is an ester of menthol and lactic acid of natural origin.


The cooling effect of Frescolat ML Cryst on the skin can be increased by adding 5 - 10% alcohol.
The cooling effect of Frescolat ML Cryst depends on the dose, but also on the type of formulation.
Polar oils such as short-chain ester oils or MCT oils have a stronger effect than non-polar oils such as long-chain vegetable oils.


However, high doses of oils and waxes can significantly reduce the cooling effect.
One possibility is to pre-dissolve the raw material in perfume oils or fatty oils, as Frescolat ML Cryst is insoluble in water, and then add it to the formulation.


Frescolat ML Cryst should be added to the emulsion at around 40 °C.
Frescolat ML Cryst is one of the menthol related cooling agents.
Frescolat ML Cryst is formed from a combination of menthol and lactic acid.


Frescolat ML Cryst is generally produced in two different forms, one as a crystalline white colored powder and another in a fused material, with slight minty flavor.
Frescolat ML Cryst is a milder form of Menthol.



USES and APPLICATIONS of FRESCOLAT ML CRYST:
Frescolat ML Cryst is a white crystalline powder used as an active cooling agent.
Frescolat ML Cryst will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat ML Cryst is odorless and tasteless and is easy to use and easy to solubilize.


Fields of use of Frescolat ML Cryst: shampoo, Rinse/Treatment, styling, Cream/lotion/skin lotion, Cleansing (face wash/body/hands/makeup remover), and Base Makeup.
Recommended usage of Frescolat ML Cryst is 0.1 to 2.0%.
Frescolat ML Cryst provides a pleasant cooling and fresh effect.


Frescolat ML Cryst generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.
Frescolat ML Cryst provides fast & mild refreshing sensation and body-responsive freshness reactivated with water (mimicking sweat).
Frescolat ML Cryst supports deodorant activity and decreases sweat odor by acting on the axillary microbiome.


Frescolat ML Cryst is used in oral care products.
Frescolat ML Cryst acts as a cooling agent.
Frescolat ML Cryst is used in oral hygiene products.


Frescolat ML Cryst is an instant yet mild cooling sensation, menthol-free, crystal form.
Optimal for pH of Frescolat ML Cryst is 4-7.
Frescolat ML Cryst is used cooling ingredient, does not contain menthol, optimal for pH values ​​4 – 8.


Dosage of Frescolat ML Cryst is 0.5-2%
Frescolat ML Cryst is a translucent solid used as an active cooling agent.
Frescolat ML Cryst is Menthyl Lactate.


Frescolat ML Cryst acts as a nature-identical, menthol-free cooling agent.
Frescolat ML Cryst is a white crystalline substance.
Frescolat ML Cryst is China compliant.


Frescolat ML Cryst is a white crystalline substance.
Frescolat ML Cryst can increase the viscosity of products that contain tensides.
Effectiveness enhanced if rapid hydration of the skin, brought about by products like O/W emulsions and gels.


Cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML Cryst is used skin care (Facial care, Facial cleansing, Body care, Baby care) Toiletries (Shower, Bath, Oral care) Hair care (Shampoos, Conditioners, Styling) Sun care (Sun protection, After-sun, Self-tanning).


Frescolat ML Cryst creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML Cryst supports deodorant activity and decreases sweat odor.
Frescolat ML Cryst is safe to use and compatible with mucous membranes.


Frescolat ML Cryst is used in oral care, skin care, hair care, shower gels, after sun, deodorants and shaving preparations.
Frescolat ML Cryst is a COSMOS approved colorless liquid used as an active cooling agent.
Frescolat ML Cryst will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.


Frescolat ML Cryst is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML Cryst can increase the viscosity of products that contain tensides.
Frescolat ML Cryst is effectiveness enhanced if rapid hydration of the skin, brought about by products like O/W emulsions and gels.


Frescolat ML Cryst is cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML Cryst is used skin care (Facial care, Facial cleansing, Body care, Baby care) Toiletries (Shower, Bath, Oral care) Hair care (Shampoos, Conditioners, Styling) Sun care (Sun protection, After-sun, Self-tanning).


Frescolat ML Cryst is suggested flavouring applications: Peppermint, spearmint, chocolate and cherry.
Frescolat ML Cryst is used for external use only.
Frescolat ML Cryst is used all kinds of skin care products.


So, Frescolat ML Cryst is safe for the skin with several beneficial effects, including skin conditioning, wound healing accelerator, insect repellent, and UV protection.
However, Frescolat ML Cryst has mild action compared to menthol, which has irritation potential.


Thanks to the water-binding ability of the lactic acid part, Frescolat ML Cryst also acts like an NMF, promoting skin hydration.
In addition, Frescolat ML Cryst stimulates cell migration and improves skin renewal rate.
Frescolat ML Cryst is stable in a wide range of pH and is used in numerous skin, lip, and hair care formulations.


The sensory perception and responses shown by Frescolat ML Cryst may be incorporated in various products in cosmetics, such as sun care products, deodorants, shower gels, facial cleanser or foams and after shave preparations.
Much like menthol, Frescolat ML Cryst exhibits a minty smell and prompts a cooling effect when applied topically.


Frescolat ML Cryst is supposed to be less sensitizing than menthol, but there’s not enough substantiated, published research supporting this notion.
However, aromatic compounds, due to their volatile nature, can cause skin sensitivity and damage, even if you can’t see any visible markers of this.
Frescolat ML Cryst’s most used in lip care, particularly for lip-plumping products, but is also found in skin care, body care and hair care.


Frescolat ML Cryst can increase the viscosity of products that contain tensides.
Frescolat ML Cryst shows enhance effectiveness if rapid hydration of the skin, brought about by products like O/W emulsions and gels.
Frescolat ML Cryst's cooling effect reduced if high percentages of oil- or wax-based cosmetic components.


Frescolat ML Cryst provides a pleasant cooling and fresh effect without the need for employing alcohol.
Frescolat ML Cryst should be added to emulsions at a temperature of around 40°C.
Frescolat ML Cryst is a translucent solid used as an active cooling agent.


Frescolat ML Cryst can be used as a cooling agent for body care, aftershave lotions and creams, shampoos, and after sun product
Applications of Frescolat ML Cryst: Facial cleanser / Lotion, milky lotion, cream / Other skin care and body care / Shampoo / Conditioner, treatment / Other hair cosmetics.


This minty-smelling compound, Frescolat ML Cryst, has been used as an insect repellent and strong flavor.
Frescolat ML Cryst has a light fragrance and is stable over a wide range of pH values (ML: pH 4-8), making it suitable for incorporation into a variety of products.


Frescolat ML Cryst has the potential to provide a refreshing and cooling sensation to the skin.
Frescolat ML Cryst helps reduce irritation by soothing the skin.
Frescolat ML Cryst helps keep microorganisms under control by preventing bacterial and fungal growth.


Frescolat ML Cryst masks unwanted odors or adds a pleasant scent to products.
Frescolat ML Cryst helps extend the shelf life of products by reducing microbial activity and preventing oxidation.
Frescolat ML Cryst can help to soothe skin irritation and calm the skin.


Frescolat ML Cryst also has mild exfoliating properties that can help remove dead skin cells and improve skin texture.
Frescolat ML Cryst can be used as an active ingredient in cooling gels, sports creams, after-sun care, shaving products and much more.
Frescolat ML Cryst provides a pleasant cooling and fresh effect.


Due to its mint-like odour, Frescolat ML Cryst is also used in flavour (oral care) and fragrance applications.
Frescolat ML Cryst generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.



FRESCOLAT ML CRYST AT A GLANCE:
*Derivative of menthol
*Exhibits a light, minty scent
*Prompts a cool, tingling sensation when applied topically
*Can cause skin sensitization



CLAIMS OF FRESCOLAT ML CRYST:
*Cooling Agents
*fresh feeling/cooling effect
*long-lasting freshness



FEATURES OF FRESCOLAT ML CRYST:
A cooling agent, Frescolat ML Cryst, that is soluble in alcohol and has a mild fragrance and excellent long-lasting cooling effect (crystals that are easy to work with)



USE AND BENEFITS OF FRESCOLAT ML CRYST:
Frescolat ML Cryst has a long-lasting and pleasant cooling effect.
When in certain preparations there are many ingredients with different fragrances and those may produce a final product with a weird smell, in that case, Frescolat ML Cryst can be used to mask original taste or fragrance and produce the uniform effect.
Frescolat ML Cryst has a refreshing effect as well, which can be helpful in powders, toothpaste, chewing gums and other oral care products.



FEATURES OF FRESCOLAT ML CRYST:
*Frescolat ML Cryst is an alcohol-soluble cooling agent (solid) with a light fragrance and excellent long-lasting cooling effect.
Fields of use of Frescolat ML Cryst: shampoo, Rinse/Treatment, styling, Cream/lotion/skin lotion, Cleansing (face wash/body/hands/makeup remover), and Base Makeup.

Frescolat ML Cryst (INCI: Menthyl Lactate), which was found to support deodorant activity.
Frescolat ML Cryst supports deodorant activity in two ways:

*reducing body odor:
limiting underarm sweat odor up to 48 hr by managing the formation of odorous sweat compounds and;
acting on the axillary microbiome management: decreasing sweat odor by reducing anaerobic bacteria development only.

*The active is available in three formats to fit a variety of formulation needs:
Frescolat ML Cryst, containing L-menthol and natural lactic acid; Frescolat ML Cryst Nat. as 100% natural menthyl lactate; and Frescolat ML Cryst Cryst. as crystalline menthyl lactate.



CLAIMS OF FRESCOLAT ML CRYST:
*Cooling Agents
*fresh feeling/cooling effect



WHAT IS FRESCOLAT ML CRYST USED FOR?
Frescolat ML Cryst is an active cooling agent that gives the skin a pleasant, intense, and prolonged feeling of freshness on the skin.
In cosmetics and personal care products, Frescolat ML Cryst serves as a masking and refreshing ingredient.

Frescolat ML Cryst can be used to cover up the original fragrance when there are numerous ingredients in a preparation with varying fragrances that could result in an odd-smelling finished product.
Additionally, Frescolat ML Cryst has a cooling effect that is beneficial in powders, toothpaste, chewing gum, and other oral care products.



ORIGIN OF FRESCOLAT ML CRYST:
Menthol and lactic acid react to produce a mixture comprising Frescolat ML Cryst and one or more higher lactoyl esters of Frescolat ML Cryst.
Hydrolysis of the esterification mixture follows in the presence of an aqueous base under conditions effective to convert the higher lactoyl esters to Frescolat ML Cryst.



WHAT DOES FRESCOLAT ML CRYST DO IN A FORMULATION?
*Masking
*Refreshing



SAFETY PROFILE OF FRESCOLAT ML CRYST:
Frescolat ML Cryst has a score of 1 on the Environmental Working Group (EWG’s) skin-deep scale, indicating a low potential for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and use restrictions.

Frescolat ML Cryst was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety.
The data showed that Frescolat ML Cryst is not genotoxic nor does it have skin sensitization potential.

Frescolat ML Cryst was found not to be a - PBT (Persistent, Bioaccumulative, and Toxic) as per the IFRA (The International Fragrance Association) Environmental Standards, and its risk quotients.
The Expert Panel for Fragrance Safety concludes that Frescolat ML Cryst is safe based on the RIFM (Research Institute for Fragrance Materials) Criteria Document.



ALTERNATIVES OF FRESCOLAT ML CRYST:
*MENTHOL



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT ML CRYST:
Product Name: Menthyl lactate
CAS No.: 17162-29-7
Molecular Formula: C13H24O3
InChIKeys: InChIKey=UJNOLBSYLSYIBM-UHFFFAOYSA-N
Molecular Weight: 228.32800
Exact Mass: 228.33
EC Number: 261-678-3
HScode: 2918110000
Categories: Synthetic Fragrances
PSA: 46.53000
XLogP3: 2.37120

Appearance: colourless liquid or white crystalline solid with
a weak chamomile or tobacco odour
Density: 0.99 g/cm3
Boiling Point: 304ºC at 760 mmHg
Flash Point: 116.0±13.2 °C
Refractive Index: 1.467
Vapor Pressure: 8.58E-05mmHg at 25°C
Molecular FormulaC13H24O3
Molecular Weight228.33
IUPAC Name(5-methyl-2-propan-2-ylcyclohexyl) 2-hydroxypropanoate
Boiling Point304.0±15.0°C at 760 Torr
Density0.99±0.1 g/cm3
InChI KeyUJNOLBSYLSYIBM-UHFFFAOYSA-N

InChIInChI=1S/C13H24O3/c1-8(2)11-6-5-9(3)7-12(11)16-13(15)10(4)14/h8-12,14H,5-7H2,1-4H3
Canonical SMILESCC1CCC(C(C1)OC(=O)C(C)O)C(C)C
Molecular Weight: 228.33 g/mol
XLogP3-AA: 3.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 228.17254462 g/mol
Monoisotopic Mass: 228.17254462 g/mol
Topological Polar Surface Area: 46.5 Ų
Heavy Atom Count: 16
Formal Charge: 0
Complexity: 237

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula: C13H24O3
Average Mass: 228.332
Monoisotopic Mass: 228.172545
Boiling Point: 297.71°C
Melting Point: 47.66°C
Solubility: Soluble in water



FIRST AID MEASURES of FRESCOLAT ML CRYST:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT ML CRYST:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT ML CRYST:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT ML CRYST:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT ML CRYST:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT ML CRYST:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

FRESCOLAT ML NAT
Frescolat ML nat. creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML nat. supports deodorant activity and decreases sweat odor.


CAS Number: 59259-38-0 / 17162-29-7
EC Number: 261-678-3
INCI Name: Menthyl Lactate
Chemical Composition: 5-methyl-2 (1-methyl ethyl) cyclohexyl-2 hydroxypropionate, l-menthyl lactate, lactic acid menthyl ester
Chem/IUPAC Name: [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate
Molecular Formula: C13H24O3



SYNONYMS:
Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, Lactic acid, p-menth-3-yl ester, 1-Methyl-4-isopropyl-3-(2-hydroxypropionate)cyclohexanol, 2-Hydroxy-propionic acid 2-isopropyl-5-methyl-cyclohexyl ester, 2-Hydroxypropanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester, 2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, Covafresh II, Fema Gras 3748, Fescolat MI Nat, Frescolat ML 620105, Frescolate ML, Koko ML, p-Menthyl lactate, Propanoic acid,2-hydroxy-,5-methyl-2-(1-methylethyl)cyclohexyl ester, Lactic acid,p-menth-3-yl ester, 1-Methyl-4-isopropyl-3-(2-hydroxypropionate)cyclohexanol, p-Menthyl lactate, Menthyl lactate, Frescolate ML, Covafresh II, Koko ML, Frescolat ML 620105, 2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, Fema Gras 3748, 2-Hydroxypropanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester, 2-Hydroxy-propionic acid 2-isopropyl-5-methyl-cyclohexyl ester, (-)-menthyl lactate, MENTHYL LACTATE, frescolat ML, 59259-38-0, l-Menthyl lactate, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate, (R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-HYDROXYPROPANOATE, 185915-25-7, L-Menthyl lactate, >=97%, SCHEMBL320044, (-)-p-Menthan-3-yl lactate, GTPL2466, FEMA 3748, L-Menthyl lactate, >=97%, FG, AKOS015964086, AC-9866, Q2640813, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, AldrichCPR, 61597-98-6, l-Menthyl lactate, L-Menthyl l-lactate, L-Menthyl (S)-lactate, Menthyl lactate [Mart.], L-Menthyl lactate [FHFI], (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (S)-2-Hydroxypropionate, MENTHYL LACTATE, FEMA No. 3748, 2S-(1R,2S,5R)-menthyl lactate, Propanoic acid, 2-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S)-, (S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, 2BF9E65L7I, (-)-menthyl lactate, (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (S)-2-hydroxypropanoate, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl (2S)-2-hydroxypropanoate, UNII-2BF9E65L7I, 59259-38-0, EC 612-179-8, SCHEMBL111620, MENTHYL LACTATE, (-)-, MENTHYL LACTATE [WHO-DD], UJNOLBSYLSYIBM-NOOOWODRSA-N, DTXSID301036338, MFCD09037384, MFCD27977194, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-2-hydroxypropanoate, AKOS027430477, AS-56902, Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1R-(1alpha(S*),2beta,5alpha))-, CS-0154344, I0889, D91210, Q27254517, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (R)-2-Hydroxypropionate, (S)-2-Hydroxypropionic Acid (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl Ester, PROPANOIC ACID, 2-HYDROXY-, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, (1R-(1.ALPHA.(S*),2.BETA.,5.ALPHA.))



Frescolat ML nat. is coolant; a safe and technological alternative to menthol, natural.
Dosage of Frescolat ML nat. is 0.5-3%
Frescolat ML nat. acts as a cooling agent.


Frescolat ML nat. provides a pleasant, intensive long-lasting freshness and cooling effect on the skin.
Frescolat ML nat. creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML nat. supports deodorant activity and decreases sweat odor.


Frescolat ML nat. is safe to use and compatible with mucous membranes.
Frescolat ML nat. is COSMOS, Ecocert approved and China compliant.
Frescolat ML nat. is a COSMOS approved colorless liquid used as an active cooling agent.


Frescolat ML nat. is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML nat. is a solid cooling agent and fragrance component for cosmetics.
Frescolat ML nat. is a derivative of menthol, but is milder and more compatible with the skin.


Melting point of Frescolat ML nat. is >35°C.
Recommended use level of Frescolat ML nat. is 0.1-3%.
Frescolat ML nat. is an ester of natural menthol and lactic acid, a highly effective and widely colorless liquid mainly used as a cooling agent.


Frescolat ML nat. provides a quick cooling and long-lasting refreshing feeling with a weak chamomile-minty odor.
Frescolat ML nat. is a food-grade ingredient used as a flavoring agent.
Frescolat ML nat. is an active cooling agent that provides a pleasant, intensive long-lasting freshness and cooling effect on the skin.


Frescolat ML nat. is the ester (chemical derivative) of menthol and lactic acid used primarily as a masking or fragrant agent in skin care and hair care.
Frescolat ML nat. may be synthetic, plant-derived or animal-derived.
Frescolat ML nat. can take the form of white crystals or white powder when in its raw material state.


Cosmetic ingredient suppliers recommend using Frescolat ML nat. in concentrations between 0.01-2.0%.
Frescolat ML nat. is a cooling agent for cosmetic products.
Frescolat ML nat. has a tonic and refreshing effect.


Frescolat ML nat. is derived from menthol but is less likely to cause irritation than pure menthol but with a similar level of cooling effect.
Frescolat ML nat. has a lower odour than Menthol.
Frescolat ML nat. is an instant yet mild cooling sensation, menthol-free, crystal form.


Frescolat ML nat. is a white crystalline powder used as an active cooling agent.
Frescolat ML nat. is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML nat. is a white crystalline powder used as an active cooling agent.


Frescolat ML nat. is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML nat. is a kind of mint derivatives, as the white needle crystal, almost no aroma, cool taste persistent, has a cooling effect, is the best substitute of mint, has many characteristics, such as long-term, insipidity, without excitant.


Frescolat ML nat. can be first mixed with oil, essence, glycol, added to the emulsion at about 35 ℃ to 40 ℃, it is also possible cold working, of course.
Frescolat ML nat. is a large complex of cooling components provides an immediate toning and refreshing feeling on the skin, as well as a feeling of cleanliness.


Frescolat ML nat. does not cause burning and does not affect the final aroma of the product.
Tanning products containing Frescolat ML nat. provide a toning feeling on the skin in 80% of respondents, and 93% confirmed the feeling of incredible freshness.


Frescolat ML nat. is used in oral care applications.
Frescolat ML nat. acts as a cooling agent.
Frescolat ML nat. dissolves in perfume oils, cosmetic oils or glycol solvents.


Frescolat ML nat. is Menthyl Lactate.
Frescolat ML nat. acts as a cooling agent.
Frescolat ML nat. dissolves in perfume oils, cosmetic oils or glycol solvents.


Frescolat ML nat. is used in oral care applications.
Frescolat ML nat. (INCI: Menthyl lactate), is a menthol derivative (menthol ester) capable of generating a mild and gentle cooling sensation on the skin.
Frescolat ML nat.'s use is now widespread in many applications (rinse-off and leave-on applications).


Well tolerated and completely odorless in formulation, Frescolat ML nat. creates a freshness in perfect affinity with the skin.
Frescolat ML nat. has been recently shown in an in vitro test that this range was helping to protect against the growth of bad bacteria in the intimate area.


This range is composed of a colourless to liquid (Frescolat ML nat.) and a powdery crystalline form (Frescolat ML nat. cryst new quality), as long as a natural one (Frescolat ML nat. nat), which is 100% natural and Ecocert certified.


This range allows to answer to all formulation needs and sustainability requirements.
A long-lasting sensation of freshness is also a key parameter for the consumers
Frescolat ML nat. is a cooling ingredient without menthol, optimal for pH values 4 – 8.


Dosage of Frescolat ML nat. is 0.5-3%
Frescolat ML nat., in the EFFA list of permitted flavoring ingredients in Europe, has a FEMA number of 3748.
Frescolat ML nat. is classified as a flavoring agent by FEMA despite its weak mint aroma and earthy taste.


Frescolat ML nat. provides a lasting feeling of freshness in the mouth.
Frescolat ML nat. is a colorless liquid to solid product. Frescolat ML nat. provides a pleasant, long-lasting freshness and cooling effect on the skin—creating the sensation of freshness and coolness without employing alcohol or menthol.


Frescolat ML nat. can be used as an active cosmetic ingredient and is safe to use and compatible with mucous membranes
Frescolat ML nat. is a colourless liquid used as an active cooling agent.
Frescolat ML nat. sensates, is cooling and refreshing, and is a signal for efficacy.


Frescolat ML nat. is a menthol-free coolant that can be used in personal care applications with acidic to neutral pH levels.
Frescolat ML nat., a menthol derivative, has an excellent cooling effect and refreshing sensation.
Frescolat ML nat. is a cooling agent for cosmetic products.


Frescolat ML nat. is derived from menthol but is less likely to cause irritation than pure menthol but with a similar level of cooling effect.
Frescolat ML nat. has a lower odor than Menthol.
Frescolat ML nat. is in the form of a white crystalline powder.


Frescolat ML nat. is soluble in water and alcohol-based solvents.
The usage rate varies between 0.1% and 2% depending on the effect of Frescolat ML nat. and its interaction with other compounds.
Frescolat ML nat. vs menthol: There is no substantiated, published research to back up the claim that this menthol derivative is less sensitizing than menthol.


Frescolat ML nat. is a gentler variation of menthol.
The cooling effect of Frescolat ML nat. is milder than that of pure menthol, but is much better tolerated by the skin.
Frescolat ML nat. is an ester of menthol and lactic acid of natural origin.


The cooling effect of Frescolat ML nat. on the skin can be increased by adding 5 - 10% alcohol.
The cooling effect of Frescolat ML nat. depends on the dose, but also on the type of formulation.
Polar oils such as short-chain ester oils or MCT oils have a stronger effect than non-polar oils such as long-chain vegetable oils.


However, high doses of oils and waxes can significantly reduce the cooling effect.
One possibility is to pre-dissolve the raw material in perfume oils or fatty oils, as Frescolat ML nat. is insoluble in water, and then add it to the formulation.


Frescolat ML nat. should be added to the emulsion at around 40 °C.
Frescolat ML nat. is one of the menthol related cooling agents.
Frescolat ML nat. is formed from a combination of menthol and lactic acid.


Frescolat ML nat. is generally produced in two different forms, one as a crystalline white colored powder and another in a fused material, with slight minty flavor.
Frescolat ML nat. is a milder form of Menthol.



USES and APPLICATIONS of FRESCOLAT ML NAT:
Frescolat ML nat. creates the sensation of freshness and coolness without employing alcohol or menthol.
Frescolat ML nat. supports deodorant activity and decreases sweat odor.
Frescolat ML nat. is safe to use and compatible with mucous membranes.


Frescolat ML nat. is used in oral care, skin care, hair care, shower gels, after sun, deodorants and shaving preparations.
Frescolat ML nat. is a COSMOS approved colorless liquid used as an active cooling agent.
Frescolat ML nat. will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.


Frescolat ML nat. is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML nat. can increase the viscosity of products that contain tensides.
Frescolat ML nat. is effectiveness enhanced if rapid hydration of the skin, brought about by products like O/W emulsions and gels.


Frescolat ML nat. is cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML nat. is used skin care (Facial care, Facial cleansing, Body care, Baby care) Toiletries (Shower, Bath, Oral care) Hair care (Shampoos, Conditioners, Styling) Sun care (Sun protection, After-sun, Self-tanning).


Frescolat ML nat. is suggested flavouring applications: Peppermint, spearmint, chocolate and cherry.
Frescolat ML nat. is used for external use only.
Frescolat ML nat. is used all kinds of skin care products.


So, Frescolat ML nat. is safe for the skin with several beneficial effects, including skin conditioning, wound healing accelerator, insect repellent, and UV protection.
However, Frescolat ML nat. has mild action compared to menthol, which has irritation potential.


Thanks to the water-binding ability of the lactic acid part, Frescolat ML nat. also acts like an NMF, promoting skin hydration.
In addition, Frescolat ML nat. stimulates cell migration and improves skin renewal rate.
Frescolat ML nat. is stable in a wide range of pH and is used in numerous skin, lip, and hair care formulations.


The sensory perception and responses shown by Frescolat ML nat. may be incorporated in various products in cosmetics, such as sun care products, deodorants, shower gels, facial cleanser or foams and after shave preparations.
Much like menthol, Frescolat ML nat. exhibits a minty smell and prompts a cooling effect when applied topically.


Frescolat ML nat. is supposed to be less sensitizing than menthol, but there’s not enough substantiated, published research supporting this notion.
However, aromatic compounds, due to their volatile nature, can cause skin sensitivity and damage, even if you can’t see any visible markers of this.


Frescolat ML nat.’s most used in lip care, particularly for lip-plumping products, but is also found in skin care, body care and hair care.
Frescolat ML nat. provides a pleasant cooling and fresh effect.


Frescolat ML nat. is a white crystalline powder used as an active cooling agent.
Frescolat ML nat. will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat ML nat. is odorless and tasteless and is easy to use and easy to solubilize.


Fields of use of Frescolat ML nat.: shampoo, Rinse/Treatment, styling, Cream/lotion/skin lotion, Cleansing (face wash/body/hands/makeup remover), and Base Makeup.
Recommended usage of Frescolat ML nat. is 0.1 to 2.0%.


Frescolat ML nat. generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.
Frescolat ML nat. provides fast & mild refreshing sensation and body-responsive freshness reactivated with water (mimicking sweat).
Frescolat ML nat. supports deodorant activity and decreases sweat odor by acting on the axillary microbiome.


Frescolat ML nat. is used in oral care products.
Frescolat ML nat. acts as a cooling agent.
Frescolat ML nat. is used in oral hygiene products.


Frescolat ML nat. is an instant yet mild cooling sensation, menthol-free, crystal form.
Optimal for pH of Frescolat ML nat. is 4-7.
Frescolat ML nat. is used cooling ingredient, does not contain menthol, optimal for pH values 4 – 8.


Dosage of Frescolat ML nat. is 0.5-2%
Frescolat ML nat. is a translucent solid used as an active cooling agent.
Frescolat ML nat. is Menthyl Lactate.


Frescolat ML nat. acts as a nature-identical, menthol-free cooling agent.
Frescolat ML nat. is a white crystalline substance.
Frescolat ML nat. is China compliant.


Frescolat ML nat. is a white crystalline substance.
Frescolat ML nat. can increase the viscosity of products that contain tensides.
Effectiveness enhanced if rapid hydration of the skin, brought about by products like O/W emulsions and gels.


Cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML nat. provides a pleasant cooling and fresh effect.


Frescolat ML nat. is used skin care (Facial care, Facial cleansing, Body care, Baby care) Toiletries (Shower, Bath, Oral care) Hair care (Shampoos, Conditioners, Styling) Sun care (Sun protection, After-sun, Self-tanning).


Frescolat ML nat. can increase the viscosity of products that contain tensides.
Frescolat ML nat. shows enhance effectiveness if rapid hydration of the skin, brought about by products like O/W emulsions and gels.
Frescolat ML nat.'s cooling effect reduced if high percentages of oil- or wax-based cosmetic components.


Frescolat ML nat. provides a pleasant cooling and fresh effect without the need for employing alcohol.
Frescolat ML nat. should be added to emulsions at a temperature of around 40°C.
Frescolat ML nat. is a translucent solid used as an active cooling agent.


Frescolat ML nat. can be used as a cooling agent for body care, aftershave lotions and creams, shampoos, and after sun product
Applications of Frescolat ML nat.: Facial cleanser / Lotion, milky lotion, cream / Other skin care and body care / Shampoo / Conditioner, treatment / Other hair cosmetics.


This minty-smelling compound, Frescolat ML nat., has been used as an insect repellent and strong flavor.
Frescolat ML nat. has a light fragrance and is stable over a wide range of pH values (ML: pH 4-8), making it suitable for incorporation into a variety of products.


Frescolat ML nat. has the potential to provide a refreshing and cooling sensation to the skin.
Frescolat ML nat. helps reduce irritation by soothing the skin.
Frescolat ML nat. helps keep microorganisms under control by preventing bacterial and fungal growth.


Frescolat ML nat. masks unwanted odors or adds a pleasant scent to products.
Frescolat ML nat. helps extend the shelf life of products by reducing microbial activity and preventing oxidation.
Frescolat ML nat. can help to soothe skin irritation and calm the skin.


Frescolat ML nat. also has mild exfoliating properties that can help remove dead skin cells and improve skin texture.
Frescolat ML nat. can be used as an active ingredient in cooling gels, sports creams, after-sun care, shaving products and much more.


Due to its mint-like odour, Frescolat ML nat. is also used in flavour (oral care) and fragrance applications.
Frescolat ML nat. generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.



FRESCOLAT ML NAT AT A GLANCE:
*Derivative of menthol
*Exhibits a light, minty scent
*Prompts a cool, tingling sensation when applied topically
*Can cause skin sensitization



CLAIMS OF FRESCOLAT ML NAT:
*Cooling Agents
*fresh feeling/cooling effect
*long-lasting freshness



FEATURES OF FRESCOLAT ML NAT.:
A cooling agent, Frescolat ML nat., that is soluble in alcohol and has a mild fragrance and excellent long-lasting cooling effect (crystals that are easy to work with)



USE AND BENEFITS OF FRESCOLAT ML NAT.:
Frescolat ML nat. has a long-lasting and pleasant cooling effect.
When in certain preparations there are many ingredients with different fragrances and those may produce a final product with a weird smell, in that case, Frescolat ML nat. can be used to mask original taste or fragrance and produce the uniform effect.
Frescolat ML nat. has a refreshing effect as well, which can be helpful in powders, toothpaste, chewing gums and other oral care products.



FEATURES OF FRESCOLAT ML NAT.:
*Frescolat ML nat. is an alcohol-soluble cooling agent (solid) with a light fragrance and excellent long-lasting cooling effect.
Fields of use of Frescolat ML nat.: shampoo, Rinse/Treatment, styling, Cream/lotion/skin lotion, Cleansing (face wash/body/hands/makeup remover), and Base Makeup.

Frescolat ML nat. (INCI: Menthyl Lactate), which was found to support deodorant activity.
Frescolat ML nat. supports deodorant activity in two ways:

*reducing body odor:
limiting underarm sweat odor up to 48 hr by managing the formation of odorous sweat compounds and;
acting on the axillary microbiome management: decreasing sweat odor by reducing anaerobic bacteria development only.

*The active is available in three formats to fit a variety of formulation needs:
Frescolat ML nat., containing L-menthol and natural lactic acid; Frescolat ML nat. Nat. as 100% natural menthyl lactate; and Frescolat ML nat. Cryst. as crystalline menthyl lactate.



CLAIMS OF FRESCOLAT ML NAT.:
*Cooling Agents
*fresh feeling/cooling effect



WHAT IS FRESCOLAT ML NAT. USED FOR?
Frescolat ML nat. is an active cooling agent that gives the skin a pleasant, intense, and prolonged feeling of freshness on the skin.
In cosmetics and personal care products, Frescolat ML nat. serves as a masking and refreshing ingredient.

Frescolat ML nat. can be used to cover up the original fragrance when there are numerous ingredients in a preparation with varying fragrances that could result in an odd-smelling finished product.
Additionally, Frescolat ML nat. has a cooling effect that is beneficial in powders, toothpaste, chewing gum, and other oral care products.



ORIGIN OF FRESCOLAT ML NAT.:
Menthol and lactic acid react to produce a mixture comprising Frescolat ML nat. and one or more higher lactoyl esters of Frescolat ML nat..
Hydrolysis of the esterification mixture follows in the presence of an aqueous base under conditions effective to convert the higher lactoyl esters to Frescolat ML nat..



WHAT DOES FRESCOLAT ML NAT. DO IN A FORMULATION?
*Masking
*Refreshing



SAFETY PROFILE OF FRESCOLAT ML NAT.:
Frescolat ML nat. has a score of 1 on the Environmental Working Group (EWG’s) skin-deep scale, indicating a low potential for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and use restrictions.

Frescolat ML nat. was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety.
The data showed that Frescolat ML nat. is not genotoxic nor does it have skin sensitization potential.

Frescolat ML nat. was found not to be a - PBT (Persistent, Bioaccumulative, and Toxic) as per the IFRA (The International Fragrance Association) Environmental Standards, and its risk quotients.
The Expert Panel for Fragrance Safety concludes that Frescolat ML nat. is safe based on the RIFM (Research Institute for Fragrance Materials) Criteria Document.



ALTERNATIVES OF FRESCOLAT ML NAT.:
*MENTHOL



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT ML NAT:
Molecular FormulaC13H24O3
Molecular Weight228.33
IUPAC Name(5-methyl-2-propan-2-ylcyclohexyl) 2-hydroxypropanoate
Boiling Point304.0±15.0°C at 760 Torr
Density0.99±0.1 g/cm3
InChI KeyUJNOLBSYLSYIBM-UHFFFAOYSA-N
InChIInChI=1S/C13H24O3/c1-8(2)11-6-5-9(3)7-12(11)16-13(15)10(4)14/h8-12,14H,5-7H2,1-4H3
Canonical SMILESCC1CCC(C(C1)OC(=O)C(C)O)C(C)C
Product Name: Menthyl lactate
CAS No.: 17162-29-7
Molecular Formula: C13H24O3
InChIKeys: InChIKey=UJNOLBSYLSYIBM-UHFFFAOYSA-N

Molecular Weight: 228.32800
Exact Mass: 228.33
EC Number: 261-678-3
HScode: 2918110000
Categories: Synthetic Fragrances
PSA: 46.53000
XLogP3: 2.37120
Appearance: colourless liquid or white crystalline solid with
a weak chamomile or tobacco odour
Density: 0.99 g/cm3
Boiling Point: 304ºC at 760 mmHg
Flash Point: 116.0±13.2 °C

Refractive Index: 1.467
Vapor Pressure: 8.58E-05mmHg at 25°C
Molecular Weight: 228.33 g/mol
XLogP3-AA: 3.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 228.17254462 g/mol
Monoisotopic Mass: 228.17254462 g/mol
Topological Polar Surface Area: 46.5 Ų
Heavy Atom Count: 16
Formal Charge: 0
Complexity: 237

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula: C13H24O3
Average Mass: 228.332
Monoisotopic Mass: 228.172545
Boiling Point: 297.71°C
Melting Point: 47.66°C
Solubility: Soluble in water



FIRST AID MEASURES of FRESCOLAT ML NAT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT ML NAT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT ML NAT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT ML NAT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT ML NAT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT ML NAT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


FRESCOLAT PLUS
Frescolat Plus is a cost effective colorless liquid patent pending blend of menthol isomers and menthyl lactate used as a cooling agent.
Frescolat Plus can be dissolved in any type of oil or Glycol or Ethyl Alcohol.


INCI Name: Menthol (and) Menthyl Lactate



SYNONYMS:
Frescolat Plus (Menthol and Menthyl Lactate), CoCool



To get an even stronger freshness effect, a mixture of menthol diastereoisomers and menthyl lactate was developed as Frescolat Plus (INCI: Menthol, Menthyl lactate).
Frescolat Plus generates a sensation like menthol but without the minty odor.


Frescolat Plus (Menthol+Menthyl Lactate) provides a cooling sensation on the skin.
How to mix: mix Frescolat Plus in oil.
Utilization rate of Frescolat Plus is 0.1-5% (use according to the desired efficiency)


Frescolat Plus is a clear liquid.
Frescolat Plus can be dissolved in any type of oil or Glycol or Ethyl Alcohol.
INCI Name of Frescolat Plus is Menthol (and) Menthyl Lactate.


Frescolat Plus is a strong, long lasting cooling effect, colorless liquid.
Optimal for pH of Frescolat Plus is 4-8.
Frescolat Plus is odorless and tasteless and is easy to use and easy to solubilize.


Frescolat Plus is a cost effective colorless liquid patent pending blend of menthol isomers and menthyl lactate used as a cooling agent.
Frescolat Plus will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat Plus is odorless and tasteless and is easy to use and easy to solubilize.


Frescolat Plus's fresh and light gel texture ABSORBS QUICKLY without leaving a greasy or oily feeling.
Frescolat Plus is endorsed by the corresponding standards with the available technical sheet applicable to cosmetic brands or those required.


Frescolat Plus's fresh and light gel texture ABSORBS QUICKLY without leaving a greasy or oily feeling.
Frescolat Plus is dermatologically tested on sensitive skin.



USES and APPLICATIONS of FRESCOLAT PLUS:
Formulated with Frescolat Plus, a patented Technology based on Menthol and Menthyl Lactate, delivers up to 20 minutes of intense and long-lasting freshness.
Frescolat Plus provides an anti-inflammatory and analgesic effect, improving blood circulation and reducing pain, swelling and muscle cramps.
Frescolat Plus is used for any product who want to feel cool when in contact with the skin


Formulated with Frescolat Plus, a patented Technology based on Menthol and Menthyl Lactate, delivers up to 20 minutes of intense and long-lasting freshness.
Frescolat Plus provides an anti-inflammatory and analgesic effect, improving blood circulation and reducing pain, swelling and muscle cramps.
Frescolat Plus is used cooling ingredient, combination of menthol and menthyl lactate.


Dosage of Frescolat Plus is 0.5-3%
Frescolat Plus is a cost effective colorless liquid patent pending blend of menthol isomers and menthyl lactate used as a cooling agent.
Frescolat Plus will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.


The “smart” component of Frescolat Plus in combination with peppermint extract refreshes, tones, deodorizes the skin of the feet, relieves the feeling of heaviness and tiredness in the legs.
Frescolat Plus relieves and refreshes tired feet and legs.


Frescolat Plus is a relaxing gel that instantly relieves fatigue and burning of feet and legs.
Formulated with Frescolat Plus, a patented Technology based on Menthol and Menthyl Lactate, delivers up to 20 minutes of intense and long-lasting freshness.
Frescolat Plus provides an anti-inflammatory and analgesic effect, improving blood circulation and reducing pain, swelling and muscle cramps.



STORAGE OF FRESCOLAT PLUS:
For long-term storage store Frescolat Plus at room temperature
Avoid Frescolat Plus heat and light.
Valid for 2 years.



BENEFITS OF FRESCOLAT PLUS:
*Cooling ingredient for rinse-off and leave-on applications
*Easy to formulate
*Mild, not an irritant
*Quick and long lasting refreshing effects
*Improves body odor
*Low use levels, cost effective



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT PLUS:
Chemical Name:Frescolat Plus (Menthol and Menthyl Lactate)
SynonymsFrescolat Plus (Menthol and Menthyl Lactate)
CBNumber:CB99911807
Molecular Formula:
Molecular Weight:0



FIRST AID MEASURES of FRESCOLAT PLUS:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT PLUS:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT PLUS:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT PLUS:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT PLUS:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT PLUS:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


FRESCOLAT X-COOL
Frescolat X-Cool is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat X-Cool is 82% stronger than Menthyl Lactate (Frescolat ML).


CAS Number: 1122460-01-8
Chemical Composition: Menthyl ethylamido oxalate
INCI Name: Menthyl Ethylamido Oxalate
Molecular formula: C14H25NO3



SYNONYMS:
menthyl ethylamido oxalate, (1R,2S,5R)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL 2-(ETHYLAMINO)-2-OXOACETATE, ACETIC ACID, 2-(ETHYLAMINO)-2-OXO-, (1R,2S,5R) -5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, FRESCOLAT X-COOL, MENTHYL ETHYLAMIDO OXALATE, Frescolat X Cool (Menthyl Ethylamido Oxalate)



Frescolat X-Cool (INCI: Menthyl Ethylamido Oxalate) provides an “icy effect” that can attract consumers looking for ever more sensory experience.
On top of its high efficacy profile, Frescolat X-Cool is also easy to process (viscous liquid product, colorless, odorless, no influence of color and odor on final formulation).


Others cosmetic applications of Frescolat X-Cool need ingredient suitable to high pH.
Frescolat X-Cool is menthyl Ethylamido Oxalate.
Frescolat X-Cool is a powerful patented cooling agent for topical applications providing an instant and long-lasting sensation of freshness.


Frescolat X-Cool will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat X-Cool is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat X-Cool is 82% stronger than Menthyl Lactate (Frescolat ML).


Frescolat X-Cool improves the sensory effects of products for hair, face and personal care as well as sun protection and shaving.
Frescolat X-Cool (INCI: Menthyl Ethylamido Oxalate) imparts a cooling effect that is felt within the first minute of application and lasts up to 30 minutes.
Frescolat X-Cool is 82% stronger than its other cooling agent menthyl lactate.


The cooling agent, Frescolat X-Cool, is gentle to the skin, compatible with mucous membranes and does not cause stinging or burning sensations.
In addition, Frescolat X-Cool is said to have no unpleasant odor.
The colorless, viscous liquid, Frescolat X-Cool, is easy to handle.


Frescolat X-Cool can be cold processable by dissolving it first in fatty acid esters, ethanol and glycols.
Frescolat X-Cool has heat stability up to 70°C.
Frescolat X-Cool is a powerful patented cooling agent for topical applications providing an instant and long-lasting sensation of freshness.


Frescolat X-Cool will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat X-Cool is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat X-Cool is 82% stronger than Menthyl Lactate (Frescolat ML).


Frescolat X-Cool is a chemical compound known for its use in various pharmaceutical and healthcare applications.
Frescolat X-Cool is primarily recognized for its cooling effect, which makes it a valuable ingredient in topical products, analgesics, and anti-inflammatory formulations.


Frescolat X-Cool's ability to provide soothing relief and its stability in various formulations have made it a sought-after ingredient in the healthcare industry.
Frescolat X-Cool is an ester of menthol and oxalic acid, with a structure that imparts distinct properties beneficial for medical and cosmetic formulations.



USES and APPLICATIONS of FRESCOLAT X-COOL:
Frescolat X-Cool acts as a coolant.
Frescolat X-Cool is a synthetic menthol derivative.
Frescolat X-Cool gives an extreme sensation of freshness.


Frescolat X-Cool exhibits excellent thermal stability up to 70 degrees.
Frescolat X-Cool is gentle on the skin and compatible with mucous membranes.
Frescolat X-Cool is used in skin care, hair care, toiletries and decorative cosmetics.


Frescolat X-Cool acts as a patented, menthol-free cooling agent.
Frescolat X-Cool provides an extreme sensation of freshness.
Frescolat X-Cool exhibits cold processable with excellent safety profile.


Frescolat X-Cool gives strong & long lasting cooling action up to 30 minutes.
Frescolat X-Cool exhibits excellent heat stability up to 70 degrees.
Frescolat X-Cool is gentle to the skin and compatible with mucous membrane.


Frescolat X-Cool is used in oral care products.
Frescolat X-Cool is used cooling ingredient, optimal in systems pH 4 - 8, provides a long-lasting cooling sensation, easy to use.
Dosage of Frescolat X-Cool is 0.2-1%


Frescolat X-Cool is a powerful patented cooling agent for topical applications providing an instant and long-lasting sensation of freshness.
Frescolat X-Cool will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
Frescolat X-Cool is odorless and tasteless and is easy to use and easy to solubilize.


Frescolat X-Cool is 82% stronger than Menthyl Lactate (Frescolat ML).
Frescolat X-Cool provides gentle, long lasting cooling sensation for skin.
The active ingredient, Frescolat X-Cool, gives skin care products a long lasting cooling effect.


On the one hand, Frescolat X-Cool works quickly – refreshing the skin immediately after application.
On the other hand, the effect can last up to 30 minutes.
And Frescolat X-Cool feels comfortable and is safe for skin.


Frescolat X-Cool safety profile allows it to be used as an active cosmetic ingredient worldwide (except in China).
Frescolat X-Cool is recommended at 0.2–1.0% in formulations with acidic to neutral pH such as: shaving products (pre/after shave lotion), deodorant (roll-on and spray), facial care, body care (body lotion and shower gel), hair care (shampoo, conditioner and styling), after sun care and lipstick/lip gloss.


Frescolat X-Cool gives skin care products a long-lasting cooling effect.
Frescolat X-Cool improves the sensory effects of products for hair, face, and personal care as well as sun protection and shaving.
On the one hand, Frescolat X-Cool works quickly – refreshing the skin immediately after application.


Frescolat X-Cool is odourless and especially suited for formulas with pH values from four to seven.
On the other hand, the effect of Frescolat X-Cool can last up to 30 minutes.
And Frescolat X-Cool feels comfortable and is safe for skin.


Frescolat X-Cool is odourless and especially suited for formulas with pH values from four to seven.
Frescolat X-Cool acts as a coolant.
Frescolat X-Cool is a synthetic menthol derivative. Frescolat X-Cool gives an extreme sensation of freshness.


Frescolat X-Cool is cold workable with excellent safety profile.
Frescolat X-Cool exhibits excellent thermal stability up to 70 degrees.


Frescolat X-Cool is gentle on the skin and compatible with mucous membranes.
Frescolat X-Cool is used in skin care, hair care, toiletries and decorative cosmetics.


-Frescolat X-Cool provides a long-lasting yet instant strong cooling effect:
* Fast action on the skin (within the first minutes)
* 30 minutes of a strong freshness on the skin
Frescolat X-Cool is an easy to handle liquid that has neither a strong odor nor a burning sensation.



KEY APPLICCATIONS OF FRESCOLAT X-COOL IN HEALTHCARE:
Frescolat X-Cool is used in a range of healthcare products, including:

*Topical Analgesics:
Known for its cooling sensation, Frescolat X-Cool provides relief in pain relief creams and gels.

*Anti-Inflammatory Products:
Frescolat X-Cool's soothing properties help reduce inflammation and discomfort.

*Cosmetic Products:
Frescolat X-Cool is used in skincare for its cooling effect and as a part of formulations targeting skin irritation and redness.



SKIN CONDITIONING OF FRESCOLAT X-COOL:
Frescolat X-Cool is used to maintain our skin tone.
Frescolat X-Cool is used as a skin conditioner.

Strong cooling that is both immediate and long-lasting is offered by Frescolat X-Cool:
- Rapid skin reaction (within the first several minutes)
- A powerful sense of freshness for 30 minutes; This is a liquid that is easy to work with and doesn't burn your tongue



FUNCTIONS OF FRESCOLAT X-COOL:
*Skin conditioning :
Frescolat X-Cool maintains skin in good condition



CLAIMS OF FRESCOLAT X-COOL:
*Cooling Agents
*long-lasting
*fresh feeling/cooling effect



GLOBAL MARKET IMPORTANCE OF FRESCOLAT X-COOL:
Market Growth and Trends:

The Frescolat X-Cool market has been experiencing notable growth due to increasing demand for innovative and effective pharmaceutical and cosmetic ingredients.
The global market for Frescolat X-Cool is expanding as companies seek to enhance product efficacy and consumer satisfaction.

Recent market analysis indicates a steady rise in the use of Frescolat X-Cool, driven by:
*Increased Demand for Topical Solutions:
The rise in chronic pain conditions and inflammatory diseases is fueling the need for effective topical treatments.

*Advancements in Formulation Technologies: Innovations in pharmaceutical and cosmetic formulation technologies are improving the application and effectiveness of Frescolat X-Cool.

*Growing Interest in Natural Ingredients:
The shift towards natural and less synthetic ingredients in healthcare products is supporting market growth.



INVESTMENT OPPORTUNITIES OF FRESCOLAT X-COOL:
Investors are increasingly looking at Frescolat X-Cool as a promising area for investment.
Frescolat X-Cool's versatility and growing applications in various healthcare segments make it an attractive option for businesses looking to capitalize on the expanding market.


Key factors driving investment include:
Innovation Potential:
The ongoing research and development in optimizing the use of Frescolat X-Cool present opportunities for new product development and market expansion.

*Strategic Partnerships:
Collaborations between pharmaceutical companies and research institutions are fostering innovation and enhancing market prospects.

*Emerging Markets:
The increasing adoption of advanced healthcare solutions in emerging markets is creating new avenues for growth.



PHYSICAL and CHEMICAL PROPERTIES of FRESCOLAT X-COOL:
Chemical Name:Frescolat X Cool (Menthyl Ethylamido Oxalate)
Synonyms: Frescolat X Cool (Menthyl Ethylamido Oxalate)
CBNumber:CB29911808
Appearance: colorless viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
CAS Registry Number: 1122460-01-8
Unique Ingredient Identifier: G2MB8B7PSM
Molecular formula: C14H25NO3
International Chemical Identifier (InChI): VTSKTHILUKZQTB-GRYCIOLGSA-N
SMILES: C(C)(C)[C@H]1[C@H](OC(C(NCC)=O)=O)C[C@H](C)CC1



FIRST AID MEASURES of FRESCOLAT X-COOL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of FRESCOLAT X-COOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FRESCOLAT X-COOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FRESCOLAT X-COOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FRESCOLAT X-COOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FRESCOLAT X-COOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


Fructose
FULVIC ACID, N° CAS : 479-66-3. Nom INCI : FULVIC ACID. Nom chimique : 1H,3H-Pyrano[4,3-b][1]benzopyran-9-carboxylic acid, 4,10-dihydro-3,7,8-trihydroxy-3-methyl-10-oxo Compatible Bio (Référentiel COSMOS) Ses fonctions (INCI) Agent d'entretien de la peau : Maintient la peau en bon état
FRUCTOSE
DESCRIPTION:
Fructose, or fruit sugar, is a ketonic simple sugar found in mana plants, where it is often bonded to glucose to form the disaccharide sucrose.
Fructose is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed by the gut directly into the blood of the portal vein during digestion.
The liver then converts both fructose and galactose into glucose, so that dissolved glucose, known as blood sugar, is the only monosaccharide present in circulating blood.

CAS NUMBER: 57-48-7
EC NUMBER: 200-333-3
IUPAC NAME:(3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
CHEMICAL FORMULA: C6H12O6

PROPERTIES OF FRUCTOSE:
MOLAR MASS: 180.156 g•mol−1
DENSITY: 1.694 g/cm3
MELTING POINT: 103 °C (217 °F; 376 K)
SOLUBILITY IN WATER: ~4000 g/L (25 °C)
MAGNETIC SUSCEPTIBILITY (χ): −102.60×10−6 cm3/mol
THERMOCHEMISTRY: Std enthalpy of combustion (ΔcH⦵298): 675.6 kcal/mol (2,827 kJ/mol) (Higher heating value)

CHEMICAL PROPERTIES OF FRUCTOSE:
Fructose is a 6-carbon polyhydroxyketone.
Crystalline fructose adopts a cyclic six-membered structure, called β-d-fructopyranose, owing to the stability of its hemiketal and internal hydrogen-bonding.
In solution, fructose exists as an equilibrium mixture of the tautomers β-d-fructopyranose, β-d-fructofuranose, α-d-fructofuranose, α-d-fructopyranose and keto-d-fructose (the non-cyclic form).
The distribution of d-fructose tautomers in solution is related to several variables, such as solvent and temperature.
d-Fructopyranose and d-fructofuranose distributions in water have been identified multiple times as roughly 70% fructopyranose and 22% fructofuranose.

REACTIONS OF FRUCTOSE:
FRUCTOSE AND FERMENTATION:
Fructose may be anaerobically fermented by yeast or bacteria.
Yeast enzymes convert sugar (sucrose, glucose, or fructose, but not lactose) to ethanol and carbon dioxide.
Some of the carbon dioxide produced during fermentation will remain dissolved in water, where it will reach equilibrium with carbonic acid.
The dissolved carbon dioxide and carbonic acid produce the carbonation in some fermented beverages, such as champagne.

FRUCTOSE AND MAILLARD REACTION:
Fructose undergoes the Maillard reaction, non-enzymatic browning, with amino acids.
Because fructose exists to a greater extent in the open-chain form than does glucose, the initial stages of the Maillard reaction occur more rapidly than with glucose.
Therefore, fructose has potential to contribute to changes in food palatability, as well as other nutritional effects, such as excessive browning, volume and tenderness reduction during cake preparation, and formation of mutagenic compounds.

DEHYDRATION OF FRUCTOSE:
Fructose readily dehydrates to give hydroxymethylfurfural ("HMF", C6H6O3), which can be processed into liquid dimethylfuran (C6H8O).
This process, in the future, may become part of a low-cost, carbon-neutral system to produce replacements for petrol and diesel from plants.

DEHYDRATION SYNTHESIS:
Through dehydration synthesis, a monosaccharide, such as fructose, binds to another monosaccharide with the release of water and the subsequent formation of a glycosidic bond.
The joining of two monosaccharides produces a disaccharide whereas the joining of three to ten monosaccharide units forms an oligosaccharide.
Polysaccharides are produced by the joining of multiple monosaccharides.
In this regard, fructose joins with another monosaccharide to form a disaccharide.

For instance, sucrose is formed when fructose and glucose molecules are joined together.
The two monosaccharides are linked through a glycosidic linkage between C-1 (on the glycosyl subunit) and C-2 (on the fructosyl unit).
Sucrose occurs in many plants.

Fructose is commonly extracted from sugar cane and sugar beet, and processed (refined) to be marketed as common table sugar.
Fructose used as a sweetening agent in food and beverages.
Synthetic disaccharide consisting of galactose and fructose has been made available not as a sweetener but for medical and health purposes.
It is called lactulose.
It is not absorbed by the body but can be metabolized by the gut flora.

Fructose is prescribed for use as a laxative, a prebiotic, and a treatment for hyperammonemia.
Fructan, a polymer of fructose, may occur as an oligosaccharide or as a polysaccharide, depending on the length of the fructose chain.
Fructan with a shorter chain is called a fructooligosaccharide.
They are present in asparagus, leeks, garlic, onions, wheat, artichoke, and grass.

SACCHARIFICATION:
The process wherein complex carbohydrates are degraded into simpler forms is called saccharification.
It entails hydrolysis. In humans and other higher animals, this involves enzymes.
In a diet containing fructose (e.g. sucrose, fructolipids, etc.), they are broken down into monomeric units through the action of digestive enzymes.

One of them is invertase (also called sucrase) released from the small intestine.
The enzyme cleaves sucrose by breaking the β-glycosidic bond, thereby, releasing glucose and fructose.
Too much fructose, though, could lead to malabsorption in the small intestine.

When this happens, unabsorbed fructose transported to the large intestine could be used in fermentation by the colonic flora.
This could lead to gastrointestinal pain, diarrhea, flatulence, or bloating due to the products (e.g. hydrogen gas, carbon dioxide, short-chain fatty acids, organic acids, and trace gases) of fructose metabolism by bacteria.

Mass extinctions occur frequently in natural history.
While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse.
Here, we describe a survival pathway used by many species as a means for providing adequate fuel and water, while also providing protection from a decrease in oxygen availability.

Fructose, whether supplied in the diet (primarily fruits and honey), or endogenously (via activation of the polyol pathway), preferentially shifts the organism towards the storing of fuel (fat, glycogen) that can be used to provide energy and water at a later date.
Fructose causes sodium retention and raises blood pressure and likely helped survival in the setting of dehydration or salt deprivation.

By shifting energy production from the mitochondria to glycolysis, fructose reduced oxygen demands to aid survival in situations where oxygen availability is low.
The actions of fructose are driven in part by vasopressin and the generation of uric acid.

Twice in history, mutations occurred during periods of mass extinction that enhanced the activity of fructose to generate fat, with the first being a mutation in vitamin C metabolism during the Cretaceous–Paleogene extinction (65 million years ago) and the second being a mutation in uricase that occurred during the Middle Miocene disruption (12–14 million years ago).
Today, the excessive intake of fructose due to the availability of refined sugar and high-fructose corn syrup is driving ‘burden of life style’ diseases, including obesity, diabetes and high blood pressure.
During the last 450 million years, there have been at least five mass extinctions that have occurred due to a variety of causes, including changes in atmosphere gases, changing global temperatures, volcanic activity and an asteroid impact .

While often the focus is on those species that failed to survive, in many respects it is the survivors that deserve the most attention, for many of these animals have developed remarkable means of survival.
Today, there are many examples of ‘extremophile’ species that can survive under remarkable situations, such as the Pompeii worm that can survive inferno (176°F) temperatures ,or the occellated icefish that lives in the Antarctic seas in the absence of red blood cells ,or the wood frog in northern Canada who freezes in winter, surviving because of the production of glycerol that acts as an antifreeze to allow slow circulation of blood in the freezing conditions .
One of the most important means for survival is to have sufficient food and water, as well as the necessary minerals, electrolytes and nutrients to maintain muscle mass and body functions.

It is also important to be able to adapt in conditions where oxygen levels may decrease.
One means for doing this is to store caches of food in one’s den, but there is always the danger that the cache could be stolen, or that the den itself may become unsafe if discovered by predators.
Thus, the ideal means for assuring survival is for the body itself to aid in the storage of food, water and other critical needs.

There appears to be a common mechanism by which many animals survive, and that it involves a unique metabolic pathway mediated by fructose, a simple sugar present in fruit.
Fructose is also produced in the body under conditions of stress.
In turn, the metabolism of fructose uniquely activates processes that stimulate survival, and it works through specific hormones (such as vasopressin) as well as metabolic products (uric acid) to mediate its effects.

Here, we provide a brief description of this central pathway that appears to have a key role in the evolution of species.
Fructose is a monosaccharide naturally present in fruit, vegetables and honey.
When combined with glucose, it forms sucrose, commonly known as sugar.
The physical and chemical properties of fructose appeal to the food industry, which produces it from cornflour.

Even though fructose is just as calorific as glucose, our body metabolises them differently.
Recent studies have focused on the potential effects of fructose on health.
Fructose was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847.
The name "fructose" was coined in 1857 by the English chemist William Allen Miller.

Pure, dry fructose is a sweet, white, odorless, crystalline solid, and is the most water-soluble of all the sugars.
Fructose is found in honey, tree and vine fruits, flowers, berries, and most root vegetables.
Fructose, or “fruit sugar”, is one of the three most common natural monosaccharides.
(The other two are glucose and galactose.)
As its name implies, fructose is found in almost all fruits; but it also exists in commercial quantities in sugarcane, sugarbeets, and corn.

Fructose and glucose combine to form the disaccharide sucrose, which we know as common sugar.
The structure of fructose, like all simple sugars, can be expressed as a six-carbon linear chain with hydroxyl and carbonyl groups.
In its crystalline form and in solution, however, most of it exists as two hemiketal rings: β-D-fructopyranose* (top) and β-D-fructofuranose* (bottom).
In aqueous solution, it consists of 70% pyranose, 22% furanose, and smaller amounts of the linear and other cyclic forms.
Fructose is the most water-soluble monosaccharide.

As indicated in the “Fast Facts” table, it dissolves in exceedingly small amounts of water.
This property makes it difficult to crystallize from water and accounts for its hygroscopicity and humectancy.
Consumption of excessive quantities of foods that contain fructose and other sugars is a well-known cause of type 2 diabetes, elevated levels of LDL (“bad”) cholesterol and triglycerides, and of course, obesity.
But fructose may be slightly safer than the others, especially for diabetics, because it has a lower glycemic index than sucrose and is considerably sweeter.

In 2016, Xia Yang, Fernando Gomez-Pinilla, and colleagues at UCLA and other institutions discovered that in lab rats fed diets high in fructose, almost 1000 genes in the brains were adversely affected.
In particular, fructose impaired two key genes that regulate intercellular communication.
But Yang and Gomez-Pinilla also had good news.
When they fed rats docosahexaenoic acid, a key ω-3 fatty acid, along with high amounts of fructose, they saw no more gene damage than in a control group.

The authors identify their study as an example of a technique called nutrigenomics, which examines the genomic bases of nutrient–host interactions that underlie disease predisposition.
Fructose is a monosaccharide, the simplest form of carbohydrate.
As the name implies, mono (one) saccharides (sugar) contain only one sugar group; thus, they can’t be broken down any further.

Each subtype of carbohydrate has different effects in the body depending on the structure and source (i.e. what food it comes from).
The chemical structure affects how quickly and/or easily the carbohydrate molecule is digested/absorbed.
The source affects whether other nutrients are provided along with the carbohydrate.
For example, both high fructose corn syrup (HFCS) and fruit contain fructose, but their effects in the body are different.

HFCS is essentially a simple fructose delivery system – there’s nothing else to it, while fruit contains additional nutrients along with fibre, which affect digestion and absorption of the fructose.
Plus, the amount of fructose in the average apple is much less than, say, the average can of soda.
Fructose has a unique texture, sweetness, rate of digestion, and degree of absorption that is different from glucose, which is the sugar that most of our ingested dietary carbohydrates become when they hit the bloodstream.
Fructose is a monosaccharide that is commonly known as fruit sugar.

Fructose naturally occurs in fruits, vegetables, honey, sugar cane, and sugar beets.
It’s around 1.5 times sweeter than typical table sugar.
Your body processes fructose differently than it does other sugars.
Fructose is metabolized in your liver and converted into energy.

This means that your body doesn’t need insulin to process fructose and that it has a smaller effect on your blood glucose levels.
Fructose is absorbed through the intestine via different mechanisms than glucose
Fructose has a slower rate of uptake

Unlike glucose, fructose does not stimulate a substantial insulin release
Fructose is transported into cells via a different transporter than glucose
Once fructose is in the liver, it can provide glycerol, the backbone of fat, and increase fat formation

Some people may be unable to completely absorb fructose when given in a high dose of around 50 grams (Note: that’s an extremely high amount of fructose.
We’re talking 4-5 medium apples.
Yet a 16 oz juice with HFCS can provide around 45 grams of fructose)
Consuming glucose with fructose at the same time accelerates the absorption of fructose.
This is one of the reasons that many sports drinks contain a mixture of sugars.
Commercially, fructose is derived from sugar cane, sugar beets, and maize.
High-fructose corn syrup is a mixture of glucose and fructose as monosaccharides.

Sucrose is a compound with one molecule of glucose covalently linked to one molecule of fructose.
All forms of fructose, including those found in fruits and juices, are commonly added to foods and drinks for palatability and taste enhancement, and for browning of some foods, such as baked goods.
As of 2004, about 240,000 tonnes of crystalline fructose were being produced annually.

Excessive consumption of sugars, including fructose, (especially from sugar-sweetened beverages) may contribute to insulin resistance, obesity, elevated LDL cholesterol and triglycerides, leading to metabolic syndrome.
The European Food Safety Authority (EFSA) stated in 2011 that fructose may be preferable over sucrose and glucose in sugar-sweetened foods and beverages because of its lower effect on postprandial blood sugar levels,[contradictory] while also noting the potential downside that "high intakes of fructose may lead to metabolic complications such as dyslipidaemia, insulin resistance, and increased visceral adiposity".

The UK's Scientific Advisory Committee on Nutrition in 2015 disputed the claims of fructose causing metabolic disorders, stating that "there is insufficient evidence to demonstrate that fructose intake, at levels consumed in the normal UK diet, leads to adverse health outcomes independent of any effects related to its presence as a component of total and free sugars."

FRUCTOSE AS A SURVIVAL FACTOR:
Fructose is unique from all other nutrients as its metabolism results in an intracellular alarm signal that triggers the organism to go into a ‘safety mode’ .
Specifically, while fructose can be metabolized by hexokinase, the enzyme fructokinase C (also known as ketohexokinase, or KHK) is the primary enzyme that metabolizes fructose, generating fructose-1-phosphate so rapidly that ATP and intracellular phosphate levels fall.


The effect is dependent on the concentration of fructose and can result in significant reductions (20–60%) of intracellular ATP as well as GTP 6 in the organs where fructokinase C is expressed, which includes the liver, kidney, brain, pancreatic islets and adipose tissues.
Fructokinase C can also be induced in tissues, such as the ischaemic heart .
The loss of intracellular phosphate activates the enzyme AMP deaminase, and this accelerates the production of inosine monophosphate (IMP) and uric acid .

The effect is further amplified by the inhibition by IMP of aldolase B, whose role is to metabolize the fructose-1-phosphate to eventually release the sequestered phosphate.
The metabolism of fructose also drives production of vasopressin, in the supraoptic nucleus of the hypothalamus, and circulating levels of vasopressin, noted by the stable metabolite, copeptin, are also regulated in part by fructose.

While fructose is found in the diet, which in the wild is principally from fruits and honey, another source of fructose is from production via the polyol pathway.
Aldose reductase converts glucose to sorbitol which is then metabolized to fructose by sorbitol dehydrogenase.
In turn, aldose reductase can be stimulated by high glucose levels (such as in diabetes), by high-salt diets (which increases osmolality, a known stimulant of aldose reductase), heat, tissue hypoxia, oxidative stress and by fructose and uric acid.
In western societies, the main sources of fructose are from table sugar (sucrose) and the sweetener, high-fructose corn syrup (HFCS).

CONSTITUTIVE UNIT OF FRUCTOSE:
Fructose is a monosaccharide, a simple sugar also called ‘fruit sugar’.
Fructose is naturally present in fruit (including berries), vegetables and honey.
Fructose is combined with glucose to form sucrose or table sugar.

The proportion of fructose varies considerably from one kind of fruit to another: 100 g of apples contain 6.0 g of fructose (56% of the total sugar content), while the same weight of apricots contains only 1 g of fructose (11% of the total sugar content).
It is important to note that the proportions of the different sugars (fructose, glucose, sucrose) also vary depending on how ripe the fruit is.

THE ROLE OF FRUCTOSE IN THE FOOD INDUSTRY:
The physical and chemical properties of fructose make it particularly interesting for the food industry.
Fructose is hygroscopic, meaning it attracts water, favours condensation and is very soluble at low temperatures.
Fructose therefore serves as a good humidifying agent for baked goods, biscuits and confectionery.

CALORIFIC VALUE, METABOLISATION AND EFFECTS ON HEALTH
The high sweetening power of fructose bears no relation to its caloric value.
In fact, in equal quantities, fructose provides as much energy as all other sugars, i.e. 4 kcal per gram.
This monosaccharide enters the bloodstream via the small intestine.

The liver then transforms it into fatty acid (10% of the fructose ingested), glucose (50%), lactate (15%) or glycogen.
Unlike glucose, the metabolism of fructose is not regulated by insulin and is less effective at triggering feelings of satiety.
Today’s scientific studies focus on the excessive consumption of fructose and its effects on health.
According to statistics, an inhabitant of the United States eats on average 55 g of fructose a day.
Current research suggests that a daily consumption in excess of 50 g raises the level of lipids in the blood (triglycerides).

COMMON USES OF FRUCTOSE:
Fructose is present not only in its natural sources, like fruits and vegetables, but also in many various products.
The main reason why producers do add fructose to their goods is to simply make their taste sweeter.
Fructose is characterized by the fading of sweetness that is faster than the one of the sucrose.
What is also characteristic for fructose is more intense taste of sweetness than those of other sugars.

A large part of producers of low-calories goods decide to use fructose due to its unique attributes.
Commonly in food production the fructose is being added not only in the form of pure fructose (known also as fructose powder) but also in the form of corn syrup.
In the food industry, fructose is used as a sweetener and preservative.

Due to its hygroscopic quality, it is useful in extending the shelf life of bakery products.
People with diabetes often replace sugar with fructose.
Fructose, like other sugars, is being used by the human body as an energy booster.

OTHER FRUCTOSE USES:
Thanks to its exceptional traits, fructose is used in many branches of food industry as well as in other industries.
Fructose can be easily found in variety types of products.

COSMETICS INDUSTRY:
Fructose is present in cosmetics as well.
Fructose is being used for its water-binding capacity.
Application of cosmetics with fructose helps one’s skin to stay hydrated and healthy.
Fructose protects skin from water loss.

Fructose also helps release skin stress and reduce its redness.
Fructose is used in huge range of sugar scrubs.
One of its main qualities valued in cosmetics industry is the fact that fructose does not melt in contact with warm skin.

PHARMACEUTICAL INDUSTRY:
Fructose is also used during the production of pharmaceuticals.
Fructose is a substrate highly valued by the medicaments’ producers.
BAKED GOODS:
Fructose is widely used to extend the shelf life of baked goods and to prevent confectionery from drying out and crystallizing.
Baked goods with added fructose are characterized by an attractive color.

ICE CREAMS:
Fructose is also used in production of ice creams.
Fructose provides a smooth consistency of an ice cream.

FRUCTOSE – EFFECTS ON THE BODY:
After consuming a product containing fructose, the sugar enters the small intestine, from where it travels to the liver, where it supports the production of glycogen, known as backup fuel.
Glycogen is used by the body after very intense exercise or long sleep.
Consuming fructose in excessive amounts can lead to fructose accumulation in the form of body fat, which in turn can cause problems with overweight, obesity and cardiovascular disease.

In addition, consuming fructose in excess can result in the development of dental caries in the mouth.
For this reason, Fructose is very important – as with many other products – to exercise moderation and caution.

FRUCTOSE – USE IN SPORTS:
Some athletes are eager to use products with a high content of fructose, the characteristics of which enable them to increase performance and reduce fatigue levels especially in conditions characterized by high temperature and humidity levels.
Fructose is most readily used by those who participate in high-intensity and endurance sports.
Fructose is an important ingredient in sports drinks, where, along with glucose, it helps replenish fluids, electrolytes and carbohydrates lost during intense exercise.

SHELF LIFE OF FRUCTOSE:
Shelf life of a product or a component is very crucial for producers and traders.
Shelf life of fructose is quite long – it lasts for 24 months.
The shelf life will be so long only if the product will be stored properly, in a cool, dry location.

GENERAL GUIDELINES:
Eliminate products with ingredients that list fructose, crystalline fructose (not HFCS), and honey on the label.
Limit drinks with HFCS to 4-8 oz at a time and try drinking them with a meal instead of on their own.
Limit commercial baked goods, candies, and other foods made with HFCS to small servings.
Enjoy these sweets with a meal, not as a snack.

Keep in mind the amount of fructose found in 2 apples or 4 tbsp of honey is the same fructose in 1 can of soda.
Eat fruit in moderation and as part of a meal.
Glucose is also a natural sugar.
The more glucose than fructose in a product, the more “intestinal friendly” the fruit or fruit juice may be.
For example, the fructose in apricots is balanced with glucose, so apricots usually do not cause problems.

Bananas and mangos are equally high in fructose, but mangos have less glucose, so they usually cause more problems.
Follow guidelines below for fruits, vegetables, and other foods that are friendlier to your intestines.
Note: The foods listed as “Foods to Avoid” should be avoided because of their high fructose content.
These are otherwise healthy foods.

ETYMOLOGY OF FRUCTOSE:
The word "fructose" was coined in 1857 from the Latin for fructus (fruit) and the generic chemical suffix for sugars, -ose. It is also called fruit sugar and levulose or laevulose.

FRUCTOSE ASSIMILATION:
Fructose that is made available from the digestion of dietary sources is taken up by the intestinal cells (enterocytes) through the proteins called glucose transporters (GluT).
GluT5 transporter takes up fructose more effectively than glucose.

There is no consensus as of this time as to how fructose is absorbed by the enterocytes.
Some scientists theorize that it involves passive transport (via facilitated diffusion).
Others presume it is by active transport just as it is in the absorption of free glucose molecules by enterocytes.

Fructose leaves the enterocytes and then enters the bloodstream.
Unlike blood glucose, fructose in the bloodstream is not regulated by the pancreatic enzymes, insulin, and glucagon.
Fructose is then transported into the cells of other tissues by facilitated diffusion using the GluT-mediated transport system (such as by GluT2 and GluT5).

FRUCTOSE CATABOLISM:
Fructose, together with the other dietary monosaccharides, is transported by the blood into the liver.
Fructose reaches the liver via the hepatic portal vein and is taken up by the liver cells.
Apart from the liver where fructose is predominantly metabolized, other tissues that metabolize fructose include the testis, kidney, skeletal muscle, fat tissues, brain, and intestine.
Fructose is taken in by these cells chiefly by GluT2 and GluT5 transporters.

The catabolism of fructose is called fructolysis (as glucose catabolism is to glycolysis).
Fructose is trapped inside the cell, e.g. inside the hepatocyte, when it is phosphorylated into fructose 1-phosphate by the enzyme fructokinase.
Fructose 1-phosphate is split by aldolase B into two trioses: (1) dihydroxyacetone phosphate (DHAP) and (2) glyceraldehyde.

THE COMMON METABOLIC FATE OF DHAP IS AS FOLLOWS:
DHAP is isomerized to glyceraldehyde 3-phosphate (Ga-3-P) by triose phosphate isomerase.
DHAP is reduced to glycerol 3-phosphate by glycerol 3-phosphate dehydrogenase.
THE COMMON METABOLIC FATE OF GLYCERALDEHYDE IS AS FOLLOWS:
Glyceraldehyde is phosphorylated into Ga-3-P‘by glyceraldehyde kinase.
Glyceraldehyde is converted into glycerol 3-phosphate by glycerol 3-phosphate dehydrogenase.

THUS, DHAP AND GA-3-P FROM FRUCTOLYSIS IN THE HEPATOCYTE MAY ENTER:
Gluconeogenesis, several metabolic pathways lead to gluconeogenesis for glucose formation.
One of them is by trioses Ga-3-P (or DHAP) combining to form the hexose, fructose-1,6-bisphosphate.
The latter is converted into fructose 6-phosphate by utilizing one water molecule and releasing one phosphate through the enzyme fructose 1,6-bisphosphatase.

Another pathway is the phosphorylation of fructose into fructose-6-phosphate, which, in turn, is converted into glucose-6-phosphate.
Glucose-6-phosphate is then hydrolyzed by the enzyme glucose-6-phosphatase to produce glucose and inorganic phosphate.

This is a more direct way than the first.
Glycogenesis, where DHAP and Ga-3-P are converted for use in glycogen synthesis
Glycolysis, where Ga-3-P (or DHAP isomerized to Ga-3-P) enters the second phase of glycolysis to be converted ultimately into pyruvate.
Pyruvate may enter the Krebs cycle in the presence of oxygen.
Another pathway is fructose entering a part of glycolysis in a rather direct way.
For instance, fructose is phosphorylated into fructose-6-phosphate.

Or, fructose-1-phosphate is phosphorylated by phosphofructokinase-1 to fructose-1,6-bisphosphate.
Free fatty acid synthesis, whereby the accumulating citrate from the Krebs cycle may be removed from the cycle to be transported to the cytosol where it will be converted into acetyl-CoA, to oxaloacetate, and then to malonyl CoA for fatty acid synthesis

Triglyceride synthesis, where glycerol 3-phosphate from DHAP and Ga-3-P may serve as glycerol backbone for triglyceride.
Triglycerides in the liver are incorporated into the very-low-density lipoproteins (VLDL) that are released to peripheral fat and muscle cells for storage.

FRUCTOSE CONVERSION INTO GLUCOSE:
A huge percentage of dietary fructose is converted in the liver to glucose.
One way by which fructose becomes glucose is when fructose is converted into Ga-3-P and DHAP that enters gluconeogenesis (the reverse of glycolysis).

POLYOL PATHWAY OF FRUCTOSE:
Polyol pathway, a two-step process, converts glucose into fructose.
The first step is the reduction of glucose to produce sorbitol through the enzyme aldose reductase.
The last step is the oxidation of sorbitol to produce fructose through the enzyme sorbitol dehydrogenase.

In bacteria, glucose converted into fructose is catalyzed by glucose isomerase, which is a bacterial enzyme.
The discovery of this enzyme led to its use in the industry, particularly in the manufacture of high fructose corn syrup.

GLYCATION:
Glycation is the process of covalently joining a carbohydrate constituent, such as fructose or glucose, to a protein or a lipid molecule. It is non-enzymatic glycosylation.

METABOLIC DISORDERS:
Improper metabolism of fructose may result in metabolic disorders.
For instance, fructose intolerance is a hereditary disease caused by a defect in the aldolase B gene that codes for the enzyme aldolase B.
In the metabolism of fructose, aldolase B cleaves fructose 1-phosphate into glyceraldehyde and DHAP.

Thus, inadequate or absence of aldolase B could lead to the improper catabolism of fructose, and hinder the various metabolic pathways that DHAP and glyceraldehyde take part in.
The condition could impair the liver and cause severe damage to it.

Another condition is fructosuria (high fructose level in urine), which is caused by an excess of fructose.
This is usually due to a defect in the gene encoding for the enzyme fructokinase.
The enzyme is supposed to phosphorylate fructose into fructose 1-phosphate.

BIOLOGICAL IMPORTANCE AND FUNCTIONS OF FRUCTOSE:
Fructose is one of the most common monosaccharides and plays various biological roles.
Fructan, a polymer of fructose, is essential to plants (e.g. grasses, asparagus, leeks, garlic, onion, wheat, except for rice that does not synthesize it).
In these plants, it serves as a storage polysaccharide.

Fructose exists in food either as a monosaccharide (free fructose) or as a unit of a disaccharide (sucrose).
Sucrose (the common table sugar) is a non-reducing disaccharide that forms when glucose and fructose are linked together by an alpha linkage between carbon 1 of glucose and carbon 2 of fructose.

Sucrose is present in different fruits, vegetables, honey, and other plant-derived food products.
When consumed, sucrose comes into contact with the membrane of the small intestine.
The enzyme sucrase catalyzes the cleavage of sucrose to yield one glucose unit and one fructose unit, which are then each absorbed by the intestine.

One of the major biological functions of fructose is it acts as an alternative metabolite in providing energy especially when glucose is not sufficient while the metabolic energy demand is high.
Fructose can enter glycolysis and produce intermediates for cellular respiration.
Fructose also enters other important metabolic pathways, such as glycogen synthesis, triglyceride synthesis, free fatty acid synthesis, and gluconeogenesis.
It can also be used during glycation wherein a lipid or a protein is combined with a sugar, such as fructose.

FRUCTOSE METABOLISM IN THE LIVER:
Glucose represents the preferred substrate for eukaryote cells, and can be used as an energy source by all cells of the human organism.
Due to the need for conserving energy between meals, and the fact that fat is more compact and lighter than carbohydrate as an energy storage form, most human cells (with the exception of the brain) have evolved to rely on glucose in the hours after meals, and on fatty acids otherwise.
In contrast, fructose cannot be directly metabolized in most cells of our organism.

Instead, it undergoes a first step processing in the liver through a pathway known as “fructolysis.” This pathway involves specific fructose-metabolizing enzymes: 1) fructokinase, which catalyzes the synthesis of fructose-1-phosphate (F-1-P); 2) aldolase B, which catalyzes its degradation into glyceraldehyde and dihydroxyacetone-phosphate (DHAP); and 3) triokinase, which converts glyceraldehyde into glyceraldehyde-3-phosphate (GAP).
The end-products of fructolysis, GAP and DHAP are also intermediates of glycolysis and hence further metabolic steps are shared with glucose metabolism.
When glucose is used as an energy substrate in the liver or in any cell type of the organism, glycolysis is tightly regulated to match cellular energy demand.

This is attained by an inhibition of phosphofructokinase (the enzyme converting fructose-6-phosphate into fructose 1,6-bisphosphate in the glycolytic pathway) by intracellular ATP and citrate levels.
In contrast, when fructose is metabolized in hepatocytes, there is no negative feedback on fructolysis enzymes, and all fructose molecules are completely converted into triose-phosphates, which are then further processed into acetyl-CoA, lactate, glucose, and eventually fatty acids and triglycerides.
The relative proportion of fructose metabolized to each of these end-products has been generally evaluated in isotope studies.

In resting subjects, 30-50% of ingested fructose was secreted into the circulation as glucose and 10-15% was stored as hepatic glycogen in the 4-6 h post ingestion.
In addition, some 25% was released into the circulation as lactate.
Finally a minor portion (~1-10%) of fructose can be converted into fatty acids and triglycerides (TG) in the metabolic pathway known as “de novo lipogenesis”.

FRUCTOSE METABOLISM IN KIDNEY PROXIMAL TUBULE CELLS AND ENTEROCYTES:
While it is generally assumed, for simplification, that fructose is metabolized in the liver, it has been long known that renal proximal tubule cells also express fructolytic enzymes.
The functional significance and possible pathological dysfunctions of kidney fructose metabolism still remain largely unexplored.
Circulating fructose concentrations generally do not exceed 0.6 mmol/L after meals, but can increase up to 1-3 mmol/L with intravenous fructose infusion.
Under such conditions, the kidneys contribute 20% of the total fructose metabolism.

Besides hepatocytes and kidney proximal tubule cells, small bowel enterocytes also express the complete enzymatic machinery required for fructose metabolism.
Enterocytes thus contribute to overall gluconeogenesis from fructose and endogenous glucose production, as well as to de novo lipogenesis and secretion of TG rich lipoprotein particles.
However, the local function of these pathways in enterocytes, and the relative contribution of the gut to overall fructose metabolism, remains speculative.

One hypothesis is that intracellular fructose metabolism may be instrumental in promoting gut fructose absorption.
Unlike glucose, which is mostly absorbed through a secondary active sodium-glucose co-transporter (SGLT1), fructose enters the enterocytes through GLUT5-mediated facilitated diffusion (Douard & Ferraris, 2013)

EFFECT OF FRUCTOSE CONSUMPTION IN HUMANS:
In healthy subjects, fructose consumption is associated with increased endogenous glucose production, fasting and postprandial plasma triglyceride and lactate concentrations, and intrahepatocellular lipid concentrations.
These metabolic alterations are the direct consequence of processing of fructose in fructokinase-expressing cells in the splanchnic area, and hence may be considered as normal adaptations to a fructose-rich diet.

When associated with a high energy intake and low physical activity, they may however favor the development of diabetes and cardiovascular diseases.
In turn, a few recent reports also indicate that early markers of these alterations can be corrected when appropriate physical activity is performed.

FRUCTOSE METABOLISM DURING EXERCISE:
Exercise is associated with a high energy requirement by the contracting muscles.
This energy can be obtained either from carbohydrate (glucose) and fat oxidation, or from anaerobic glycolysis alone (for relatively short periods of time).
Carbohydrate oxidation during exercise is partially dependent on exogenous carbohydrate intake.

Glucose ingested during exercise is oxidized in a dose-dependent manner until a plateau is reached at ~1.0 g/min.
It has been proposed that this limit is due to exogenous glucose absorption being maximal at these rates of glucose ingestion.
Many studies have evaluated whether fructose drinks may be beneficial during exercise.

Labelled (13C) fructose has been shown to be oxidized during exercise; however, pure fructose did not confer any advantage compared to glucose. In fact, adverse gastrointestinal effects secondary to icomplete gut absorption of pure fructose may be observed .

Fructose, however, may have beneficial effects when administered together with glucose by increasing total gut hexoses’ absorption. Indeed, fructose enters the enterocyte through a facilitated glucose transporter GLUT5 rather than through the SGLT1 used for glucose.

Several studies have documented that larger maximal total and exogenous carbohydrate oxidations were obtained with the ingestion of fructose-glucose mixtures vs. glucose alone.
The increase in total carbohydrate oxidation with the addition of fructose to glucose drinks in exercising athletes may appear surprising given the absence of fructokinase in skeletal muscle, and the fact that muscle hexokinase has a much lower affinity for fructose than glucose.
It therefore appears to reflect oxidation by muscles of glucose and/or lactate synthesized from fructose in hepatocytes.

ENERGETICS OF FRUCTOSE AND GLUCOSE DURING EXERCISE:
Replacing glucose with fructose as a dietary energy source during exercise has some consequences on muscle energy efficiency.
Glucose is taken up by contacting skeletal muscles and results in the total synthesis of 29.5 ATP.
Overall, the oxidation of 1 molecule of plasma glucose uses 6 molecules of oxygen (O2) and 2 ATP and produces 6 molecules of carbon dioxide (CO2) and 29.5 ATP, corresponding to 27.5 ATP gained in working muscle, i.e., 4.58 ATP/O2 molecule.

In comparison, ATP, O2 and CO2 fluxes slightly vary when fructose is first metabolized in the liver to be secondarily oxidized in muscle.
When fructose is converted into glucose in the liver it consumes 2 ATP.
When this newly synthesized glucose is subsequently oxidized in skeletal muscle, the overall metabolic pathway uses 6 O2 and 4 ATP and produces 6 CO2 and 29.5 ATP for each fructose molecule, representing a net gain of 25.5 ATP, or 4.25 ATP/oxygen.

Interestingly, the energy yield in skeletal muscle is identical to that of glucose, but there is additional energy expended in the liver.
When fructose is converted into lactate, which is subsequently oxidized in contracting muscle, the overall metabolic process uses 6 O2 and 2 ATP and produces 6 CO2 and 29.5 ATP as with direct oxidation.
In the liver, however, fructolysis consumes 2 ATP and conversion to pyruvate produces 4 ATP, resulting in 2 ATP gained.
In contrast, in skeletal muscle, 2 lactates are transported into the cells through facilitated diffusion, and their complete mitochondrial oxidation requires 6 O2 and produces 25.5 ATP, corresponding to 4.25 ATP/oxygen.
In summary, the energy efficiency for fructose oxidation in muscle is somewhat lower than for dietary glucose or starch oxidation.
However, hepatic fructolysis into lactate may provide a substantial energy supply to the working muscle when the glycolysis rate is limiting.

PHYSICAL AND FUNCTIONAL PROPERTIES OF FRUCTOSE
The carbohydrate can be fermented anaerobically with the help of yeast or bacteria in which they are converted into carbon dioxide and ethanol.
Fruit sugar is used in Maillard Reaction with amino acids over glucose as the reaction occurs rapidly as they are present in an open-chain form.
These compounds dehydrate rapidly to give hydroxymethylfurfural. (‘HMF’).

Fructose is a white crystalline solid.
These carbohydrates are highly soluble when compared to other sugars.
They absorb moisture quickly and release it slowly into the environment with respect to other sugars.

STRUCTURE OF FRUCTOSE:
Fructose has a cyclic structure.
Due to the presence of the keto group, it results in the formation of the intramolecular hemiacetal.
In this arrangement, C5-OH combines with the ketonic group present in the second position.

This results in the formation of chiral carbon and two arrangements of CH2OH and OH group.
Hence, D-fructose exhibits stereoisomerism in which α-D-fructopyranose and β-D-fructopyranose are the isomers.

RING STRUCTURE FOR FRUCTOSE:
The chair form of fructose follows a similar pattern as that for glucose with a few exceptions.
Since fructose has a ketone functional group, the ring closure occurs at carbon.
In the case of fructose a five membered ring is formed.
The -OH on carbon is converted into the ether linkage to close the ring with carbon.
This makes a 5 member ring - four carbons and one oxygen.

STEPS IN THE RING CLOSURE (HEMIACETAL SYNTHESIS):
The electrons on the alcohol oxygen are used to bond the carbon to make an either.
The hydrogen is transferred to the carbonyl oxygen to make a new alcohol group.

HEMIACETAL FUNCTIONAL GROUP:
The anomeric carbon is the center of a hemiacetal functional group.
A carbon that has both an ether oxygen and an alcohol group (and is attached to two other carbons is a hemiacetal.

USES OF FRUCTOSE:
Crystalline fructose is used in enhancing the taste in food industries.
Fructose used in flavoured water, energy drinks, low-calorie products, etc.
Fruit sugar is used in the manufacturing of soft moist cookies, nutrition bars, reduced-calorie products etc

SWEETNESS OF FRUCTOSE:
The primary reason that fructose is used commercially in foods and beverages, besides its low cost, is its high relative sweetness.
Fructose the sweetest of all naturally occurring carbohydrates.
The relative sweetness of fructose has been reported in the range of 1.2–1.8 times that of sucrose.

However, it is the 6-membered ring form of fructose that is sweeter; the 5-membered ring form tastes about the same as usual table sugar.
Warming fructose leads to formation of the 5-membered ring form.
Therefore, the relative sweetness decreases with increasing temperature.
However it has been observed that the absolute sweetness of fructose is identical at 5 °C as 50 °C and thus the relative sweetness to sucrose is not due to anomeric distribution but a decrease in the absolute sweetness of sucrose at higher temperatures.
The sweetness of fructose is perceived earlier than that of sucrose or glucose, and the taste sensation reaches a peak (higher than that of sucrose), and diminishes more quickly than that of sucrose.

Fructose can also enhance other flavors in the system.
Fructose exhibits a sweetness synergy effect when used in combination with other sweeteners.
The relative sweetness of fructose blended with sucrose, aspartame, or saccharin is perceived to be greater than the sweetness calculated from individual components.

FRUCTOSE SOLUBILITY AND CRYSTALLIZATION:
Fructose has higher water solubility than other sugars, as well as other sugar alcohols.
Fructose is, therefore, difficult to crystallize from an aqueous solution.
Sugar mixes containing fructose, such as candies, are softer than those containing other sugars because of the greater solubility of fructose.

FRUCTOSE HYGROSCOPICITY AND HUMECTANCY:
Fructose is quicker to absorb moisture and slower to release it to the environment than sucrose, glucose, or other nutritive sweeteners.
Fructose is an excellent humectant and retains moisture for a long period of time even at low relative humidity (RH).
Therefore, fructose can contribute a more palatable texture, and longer shelf life to the food products in which it is used.

FREEZING POINT OF FRUCTOSE
Fructose has a greater effect on freezing point depression than disaccharides or oligosaccharides, which may protect the integrity of cell walls of fruit by reducing ice crystal formation.
However, this characteristic may be undesirable in soft-serve or hard-frozen dairy desserts.

FRUCTOSE AND STARCH FUNCTIONALITY IN FOOD SYSTEMS:
Fructose increases starch viscosity more rapidly and achieves a higher final viscosity than sucrose because fructose lowers the temperature required during gelatinizing of starch, causing a greater final viscosity.
Although some artificial sweeteners are not suitable for home-baking, many traditional recipes use fructose.

FOOD SOURCES OF FRUCTOSE:
Natural sources of fructose include fruits, vegetables (including sugar cane), and honey.
Fructose is often further concentrated from these sources.
The highest dietary sources of fructose, besides pure crystalline fructose, are foods containing white sugar (sucrose), high-fructose corn syrup, agave nectar, honey, molasses, maple syrup, fruit and fruit juices, as these have the highest percentages of fructose (including fructose in sucrose) per serving compared to other common foods and ingredients.
Fructose exists in foods either as a free monosaccharide or bound to glucose as sucrose, a disaccharide.

Fructose, glucose, and sucrose may all be present in a food; however, different foods will have varying levels of each of these three sugars.
All data with a unit of g (gram) are based on 100 g of a food item.
The fructose/glucose ratio is calculated by dividing the sum of free fructose plus half sucrose by the sum of free glucose plus half sucrose.

Fructose is also found in the manufactured sweetener, high-fructose corn syrup (HFCS), which is produced by treating corn syrup with enzymes, converting glucose into fructose.
The common designations for fructose content, HFCS-42 and HFCS-55, indicate the percentage of fructose present in HFCS.
HFCS-55 is commonly used as a sweetener for soft drinks, whereas HFCS-42 is used to sweeten processed foods, breakfast cereals, bakery foods, and some soft drinks.

Cane and beet sugars have been used as the major sweetener in food manufacturing for centuries.
However, with the development of HFCS, a significant shift occurred in the type of sweetener consumption in certain countries, particularly the United States.
Contrary to the popular belief, however, with the increase of HFCS consumption, the total fructose intake relative to the total glucose intake has not dramatically changed.

Granulated sugar is 99.9%-pure sucrose, which means that it has equal ratio of fructose to glucose.
The most commonly used forms of HFCS, HFCS-42, and HFCS-55, have a roughly equal ratio of fructose to glucose, with minor differences.
HFCS has simply replaced sucrose as a sweetener.
Therefore, despite the changes in the sweetener consumption, the ratio of glucose to fructose intake has remained relatively constant.

NUTRITIONAL INFORMATION OF FRUCTOSE:
Providing 368 kcal per 100 grams of dry powder, fructose has 95% the caloric value of sucrose by weight.
Fructose powder is 100% carbohydrates and supplies no other nutrients in significant amount.

FRUCTOSE DIGESTION AND ABSORPTION IN HUMANS:
Fructose exists in foods either as a monosaccharide (free fructose) or as a unit of a disaccharide (sucrose).
Free fructose is absorbed directly by the intestine.
When fructose is consumed in the form of sucrose, it is digested (broken down) and then absorbed as free fructose.
As sucrose comes into contact with the membrane of the small intestine, the enzyme sucrase catalyzes the cleavage of sucrose to yield one glucose unit and one fructose unit, which are then each absorbed.

After absorption, it enters the hepatic portal vein and is directed toward the liver.
The mechanism of fructose absorption in the small intestine is not completely understood.
Some evidence suggests active transport, because fructose uptake has been shown to occur against a concentration gradient.
However, the majority of research supports the claim that fructose absorption occurs on the mucosal membrane via facilitated transport involving GLUT5 transport proteins.
Since the concentration of fructose is higher in the lumen, fructose is able to flow down a concentration gradient into the enterocytes, assisted by transport proteins.
Fructose may be transported out of the enterocyte across the basolateral membrane by either GLUT2 or GLUT5, although the GLUT2 transporter has a greater capacity for transporting fructose, and, therefore, the majority of fructose is transported out of the enterocyte through GLUT2.

CAPACITY AND RATE OF ABSORPTION OF FRUCTOSE:
The absorption capacity for fructose in monosaccharide form ranges from less than 5 g to 50 g (per individual serving) and adapts with changes in dietary fructose intake.
Studies show the greatest absorption rate occurs when glucose and fructose are administered in equal quantities.
When fructose is ingested as part of the disaccharide sucrose, absorption capacity is much higher because fructose exists in a 1:1 ratio with glucose.

It appears that the GLUT5 transfer rate may be saturated at low levels, and absorption is increased through joint absorption with glucose.
One proposed mechanism for this phenomenon is a glucose-dependent cotransport of fructose.
In addition, fructose transfer activity increases with dietary fructose intake.

The presence of fructose in the lumen causes increased mRNA transcription of GLUT5, leading to increased transport proteins.
High-fructose diets (>2.4 g/kg body wt) increase transport proteins within three days of intake.

MALABSORPTION OF FRUCTOSE:
Several studies have measured the intestinal absorption of fructose using the hydrogen breath test.
These studies indicate that fructose is not completely absorbed in the small intestine.
When fructose is not absorbed in the small intestine, fructose transported into the large intestine, where fructose fermented by the colonic flora.
Hydrogen is produced during the fermentation process and dissolves into the blood of the portal vein.

This hydrogen is transported to the lungs, where it is exchanged across the lungs and is measurable by the hydrogen breath test.
The colonic flora also produces carbon dioxide, short-chain fatty acids, organic acids, and trace gases in the presence of unabsorbed fructose.
The presence of gases and organic acids in the large intestine causes gastrointestinal symptoms such as bloating, diarrhea, flatulence, and gastrointestinal pain.
Exercise immediately after consumption can exacerbate these symptoms by decreasing transit time in the small intestine, resulting in a greater amount of fructose emptied into the large intestine.

FRUCTOSE METABOLISM:
All three dietary monosaccharides are transported into the liver by the GLUT2 transporter.
Fructose and galactose are phosphorylated in the liver by fructokinase (Km= 0.5 mM) and galactokinase (Km = 0.8 mM), respectively.
By contrast, glucose tends to pass through the liver (Km of hepatic glucokinase = 10 mM) and can be metabolised anywhere in the body.

Uptake of fructose by the liver is not regulated by insulin.
However, insulin is capable of increasing the abundance and functional activity of GLUT5, fructose transporter, in skeletal muscle cells.

FRUCTOLYSIS:
The initial catabolism of fructose is sometimes referred to as fructolysis, in analogy with glycolysis, the catabolism of glucose.
In fructolysis, the enzyme fructokinase initially produces fructose 1-phosphate, which is split by aldolase B to produce the trioses dihydroxyacetone phosphate (DHAP) and glyceraldehyde.
Unlike glycolysis, in fructolysis the triose glyceraldehyde lacks a phosphate group.

A third enzyme, triokinase, is therefore required to phosphorylate glyceraldehyde, producing glyceraldehyde 3-phosphate.
The resulting trioses are identical to those obtained in glycolysis and can enter the gluconeogenic pathway for glucose or glycogen synthesis, or be further catabolized through the lower glycolytic pathway to pyruvate.

METABOLISM OF FRUCTOSE TO DHAP AND GLYCERALDEHYDE:
The first step in the metabolism of fructose is the phosphorylation of fructose to fructose 1-phosphate by fructokinase, thus trapping fructose for metabolism in the liver.
Fructose 1-phosphate then undergoes hydrolysis by aldolase B to form DHAP and glyceraldehydes; DHAP can either be isomerized to glyceraldehyde 3-phosphate by triosephosphate isomerase or undergo reduction to glycerol 3-phosphate by glycerol 3-phosphate dehydrogenase.

The glyceraldehyde produced may also be converted to glyceraldehyde 3-phosphate by glyceraldehyde kinase or further converted to glycerol 3-phosphate by glycerol 3-phosphate dehydrogenase.
The metabolism of fructose at this point yields intermediates in the gluconeogenic pathway leading to glycogen synthesis as well as fatty acid and triglyceride synthesis.

SYNTHESIS OF GLYCOGEN FROM DHAP AND GLYCERALDEHYDE 3-PHOSPHATE:
The resultant glyceraldehyde formed by aldolase B then undergoes phosphorylation to glyceraldehyde 3-phosphate.
Increased concentrations of DHAP and glyceraldehyde 3-phosphate in the liver drive the gluconeogenic pathway toward glucose and subsequent glycogen synthesis.
It appears that fructose is a better substrate for glycogen synthesis than glucose and that glycogen replenishment takes precedence over triglyceride formation.
Once liver glycogen is replenished, the intermediates of fructose metabolism are primarily directed toward triglyceride synthesis.

SYNTHESIS OF TRIGLYCERIDE FROM DHAP AND GLYCERALDEHYDE 3-PHOSPHATE:
Carbons from dietary fructose are found in both the free fatty acid and glycerol moieties of plasma triglycerides.
High fructose consumption can lead to excess pyruvate production, causing a buildup of Krebs cycle intermediates.
Accumulated citrate can be transported from the mitochondria into the cytosol of hepatocytes, converted to acetyl CoA by citrate lyase and directed toward fatty acid synthesis.
In addition, DHAP can be converted to glycerol 3-phosphate, providing the glycerol backbone for the triglyceride molecule.
Triglycerides are incorporated into very-low-density lipoproteins (VLDL), which are released from the liver destined toward peripheral tissues for storage in both fat and muscle cells.

POTENTIAL HEALTH EFFECTS OF FRUCTOSE:
In 2022, the European Food Safety Authority (EFSA) stated that there is research evidence that fructose and other added free sugars may be associated with increased risk of several chronic diseases:[contradictory] the risk is moderate for obesity and dyslipidemia (more than 50%), and low for non-alcoholic fatty liver disease, type 2 diabetes (from 15% to 50%) and hypertension.
EFSA further stated that clinical research did "not support a positive relationship between the intake of dietary sugars, in isocaloric exchange with other macronutrients, and any of the chronic metabolic diseases or pregnancy-related endpoints assessed" but advised "the intake of added and free sugars should be as low as possible in the context of a nutritionally adequate diet."

CARDIOMETABOLIC DISEASES:
When fructose is consumed in excess as a sweetening agent in foods or beverages, it may be associated with increased risk of obesity, diabetes, and cardiovascular disorders that are part of metabolic syndrome.

COMPARED WITH SUCROSE:
Fructose was found to increase triglycerides in type-2 but not type-1 diabetes and moderate use of it has previously been considered acceptable as a sweetener for diabetics, possibly because it does not trigger the production of insulin by pancreatic β cells.
For a 50 gram reference amount, fructose has a glycemic index of 23, compared with 100 for glucose and 60 for sucrose.

Fructose is also 73% sweeter than sucrose at room temperature, allowing diabetics to use less of it per serving.
Fructose consumed before a meal may reduce the glycemic response of the meal.
Fructose-sweetened food and beverage products cause less of a rise in blood glucose levels than do those manufactured with either sucrose or glucose.

FREQUENTLY ASKED QUESTIONS:
What is fructose used for?
Fructose is a basic natural sugar found in fruits, honeys, and vegetables.
Since the mid-1850s, fructose in its pure form has been used as a sweetener and has advantages for certain groups including people with diabetes and those who try to control their weight.

What is the difference between glucose and fructose?
Glucose and fructose constitute basic sugars.
Simple carbohydrates are broken down into two groups.
These are both disaccharide and monosaccharide.

Monosaccharides consist of one unit of sugar and are the most basic type of sugar.
Fructose and glucose are both basic sugars made from monosaccharides.
Starch and sugar, whether sucrose or high- (HCFS), contain large quantities of glucose when digested.

What are the properties of fructose?
For general, fructose has a lower melting point compared with other sugars such as glucose, which has a melting point of 146°C.
The fructose compound has a 180.16 mol / g molar mass, and a density of 1.69g / cm2. Refined crystallized fructose is pure and powdery.

How many atoms are in fructose?
Fructose, or levulose, is the sugar source present in both fruit and honey.
This is a monosaccharide laevorotator with the same empirical formula as glucose but with a different structure.
Though fructose is a hexose (6 atoms of carbon), it typically exists as a 5-membered hemiketal ring (a furanose).

What is the molecule fructose?
Fructose, or fruit sugar, is a simple ketonic monosaccharide found in many plants, where glucose is often bonded to form the sucrose disaccharide.
As well as glucose and galactose, Fructose is one of the three dietary monosaccharides that are absorbed directly into the blood during digestion.
FRUCTOSE
Fructose or fruit sugar, is a ketonic simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose.
Fructose is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed by the gut directly into the blood of the portal vein during digestion.
The liver then converts both fructose and galactose into glucose, so that dissolved glucose, known as blood sugar, is the only monosaccharide present in circulating blood.

CAS: 57-48-7
MF: C6H12O6
MW: 180.16
EINECS: 200-333-3

Fructose was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847.
The name "fructose" was coined in 1857 by the English chemist William Allen Miller.
Pure, dry fructose is a sweet, white, odorless, crystalline solid, and is the most water-soluble of all the sugars.
Fructose is found in honey, tree and vine fruits, flowers, berries, and most root vegetables.

Commercially, fructose is derived from sugar cane, sugar beets, and maize.
High-fructose corn syrup is a mixture of glucose and fructose as monosaccharides.
Sucrose is a compound with one molecule of glucose covalently linked to one molecule of fructose.
All forms of fructose, including those found in fruits and juices, are commonly added to foods and drinks for palatability and taste enhancement, and for browning of some foods, such as baked goods.
As of 2004, about 240,000 tonnes of crystalline fructose were being produced annually.

Excessive consumption of sugars, including fructose, (especially from sugar-sweetened beverages) may contribute to insulin resistance, obesity, elevated LDL cholesterol and triglycerides, leading to metabolic syndrome.
The European Food Safety Authority (EFSA) stated in 2011 that fructose may be preferable over sucrose and glucose in sugar-sweetened foods and beverages because of its lower effect on postprandial blood sugar levels, while also noting the potential downside that "high intakes of fructose may lead to metabolic complications such as dyslipidaemia, insulin resistance, and increased visceral adiposity".
The UK's Scientific Advisory Committee on Nutrition in 2015 disputed the claims of fructose causing metabolic disorders, stating that "there is insufficient evidence to demonstrate that fructose intake, at levels consumed in the normal UK diet, leads to adverse health outcomes independent of any effects related to its presence as a component of total and free sugars."

Fructose is present as a monosaccharide in fruits and vegetables, as a disaccharide in sucrose (with D-glucose), and as oligoand polysaccharides (fructans) in many plants.
Fructose is also used as an added sweetener for food and drink, and as an excipient in pharmaceutical preparations, syrups, and solutions.
In equal amounts, Fructose is sweeter than glucose or sucrose and is therefore commonly used as a bulk sweetener.
An increase in high fructose corn syrup, as well as total fructose, consumption over the past 10 to 20 years has been linked to a rise in obesity and metabolic disorders.
This raises concerns regarding the short and long-term effects of fructose in humans.
Fructose is present more or less frequently than glucose in the juices of plants, fruits, and especially the honey, which is about half the solid matters.
Fructose leads to an equal amount of glucose by the hydrolysis of sugar cane and a smaller proportion than some other less common sugars.

Fructose is used, such as glucose, in the production of glycogen.
Fructose enters the body through either be eaten as such or as the result of digestion of sugar cane.
Fructose is mainly changed into glycogen or triglycerides after reaching the liver, so do not enter largely in the blood circulation.
Glucose and fructose are partially inter-convertible under the influence of very dilute alkali.
Fructose is not surprising; therefore, that fructose must be converted to glycogen in the liver, which on hydrolysis yields of glucose.
Dubois et al. reported that regular consumption of sugary drinks between meals increases risk of overweight among preschool children.
Fructose has been claimed to be of concern due to several factors: First, in the 1980’s, sucrose was replaced to a large extent, particularly in North America, by high fructose corn syrup (HFCS) in carbonated beverages.
The intake of soft drinks containing HFCS has risen in parallel with the epidemic of obesity.

Second, dietary fructose has been implicated in risk factors for cardiovascular disease (CVD):
1. Plasma triglycerides (TG) and VLDL-TG increased following the ingestion of large quantities of fructose;
2. Fructose intake has been found to predict LDL particle size in overweight schoolchildren.
3. A positive relationship has been demonstrated between fructose intake and uric acid levels.
Third, the use of fructose as a sweetener has increased.
The third National Health Examination Survey (NHANES) demonstrated that over 10% of Americans’ daily calories were from fructose.
These studies suggest that the relationship between fructose and health needs re-evaluation.

History of fructose consumption
Before the development of the sugar industry, free fructose was found in relatively few foods.
Relatively few unprocessed foods contain any significant amounts of free fructose monosaccharide.
Historically, these foods have been relatively hard to obtain and they typically contain fructose in conjunction with glucose and/or fibre, which has significant implications for the absorption and metabolism of the former.
As a consequence, humans have historically had low dietary fructose intakes.

Biomedical importance of fructose
Fructose occurs due to deficiency of aldolase B.
Fructose has been observed in children, when children receive fructose in the diet.
The vomiting and hypoglycemia is an important feature of Fructose.
Fructose 1 phosphate accumulates in the liver.
Accumulation exhausts inorganic phosphate thereby inhibiting both glycogen phosphorylase and the synthesis of ATP.
Inhibition of these reactions leads to hypoglycaemia.
AMP also accumulates and metabolism leads to increased production of uric acid leading to hyperuricemia and gout.
Treatment of Fructose includes avoiding substances containing fructose.

Fructose metabolism
Sugar is present in fruits. Sucrose is hydrolyzed by sucrase to glucose and fructose.
Dietary fructose is transferred from the intestine to the liver for metabolism.
Fructose is converted to fructose 1 phosphate that further converted to acetone and glyceraldehyde dihydroxy, which is further converted to glyceraldehyde 3 phosphate to enter glycolysis.
In the well-fed state, fructose is converted to glycogen or triglycerides.
Hyperlipidemia, diabetes mellitus and obesity are interlinked.
Consumption of fructose is increasing and is considered responsible for overweight.
Several studies show that fructose increases incidence of obesity, dyslipidemia, insulin resistance, and hypertension.
Metabolism of fructose takes place mainly in the liver and high fructose stream leads to accumulation of triglycerides in the liver (hepatic steatosis).

This results in impairment of lipid metabolism and enhancement of expression of proinflammatory cytokine.
Fructose alters glucose-induced expression of activated acetyl CoA carboxylase (ACC), pSer hormone sensitive lipase (pSerHSL) and adipose triglyceride lipase (ATGL) in HepG2 liver or primary liver cell cultures in vitro.
This relates to the increased de novo synthesis of triglycerides in vitro and in vivo hepatic steatosis in fructose-fed versus glucose-and standard-diet mice fed.
These studies provide new understanding of the mechanisms involved in fructose-mediated hepatic hypertriglyceridemia.
Rate of metabolism of fructose is more rapid than glucose, because triose formed from fructose 1-phosphate by pass phosphofructokinase, the primary rate-limiting step in glycolysis.
Elevated levels of dietary fructose significantly elevate the rate of lipogenesis in the liver, because of the rapid production of acetyl-coenzyme A.

Fructose Chemical Properties
Melting point: 119-122 °C (dec.)(lit.)
Alpha: -92.25 º (c=10,H2O,on dry sub.)
Boiling point: 232.96°C (rough estimate)
Density: 1.59
Refractive index: -92 ° (C=4, H2O)
Storage temp.: room temp
Solubility H2O: 1 M at 20 °C, clear, colorless
Form: Crystals or Crystalline Powder
Pka: pKa (18°): 12.06
color: White
PH: 5.0-7.0 (25℃, 0.1M in H2O)
Odor: at 100.00 %. odorless
Odor Type: odorless
optical activity: [α]20/D 93.5 to 91.0°, c = 10% in H2O
Water Solubility: 3750 g/L (20 ºC)
λmax λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.04
Merck: 14,4273
BRN: 1239004
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey: LKDRXBCSQODPBY-GWVKGMJFSA-N
LogP: -1.029 (est)
CAS DataBase Reference: 57-48-7(CAS DataBase Reference)
NIST Chemistry Reference: Fructose(57-48-7)
EPA Substance Registry System: Fructose(57-48-7)

Fructose is a 6-carbon polyhydroxyketone.
Crystalline fructose adopts a cyclic six-membered structure, called β-d-fructopyranose, owing to the stability of its hemiketal and internal hydrogen-bonding.
In solution, fructose exists as an equilibrium mixture of the tautomers β-d-fructopyranose, β-d-fructofuranose, α-d-fructofuranose, α-d-fructopyranose and keto-d-fructose (the non-cyclic form).

The distribution of d-fructose tautomers in solution is related to several variables, such as solvent and temperature.
d-Fructopyranose and d-fructofuranose distributions in water have been identified multiple times as roughly 70% fructopyranose and 22% fructofuranose.

Reactions
Fructose and fermentation
Fructose may be anaerobically fermented by yeast or bacteria.
Yeast enzymes convert sugar (sucrose, glucose, or fructose, but not lactose) to ethanol and carbon dioxide.
Some of the carbon dioxide produced during fermentation will remain dissolved in water, where it will reach equilibrium with carbonic acid.
The dissolved carbon dioxide and carbonic acid produce the carbonation in some fermented beverages, such as champagne.

Fructose and Maillard reaction
Fructose undergoes the Maillard reaction, non-enzymatic browning, with amino acids.
Because fructose exists to a greater extent in the open-chain form than does glucose, the initial stages of the Maillard reaction occur more rapidly than with glucose.
Therefore, fructose has potential to contribute to changes in food palatability, as well as other nutritional effects, such as excessive browning, volume and tenderness reduction during cake preparation, and formation of mutagenic compounds.

Dehydration
Fructose readily dehydrates to give hydroxymethylfurfural ("HMF", C6H6O3), which can be processed into liquid dimethylfuran (C6H8O).
This process, in the future, may become part of a low-cost, carbon-neutral system to produce replacements for petrol and diesel from plants.

Physical and functional properties
Sweetness of fructose
The primary reason that fructose is used commercially in foods and beverages, besides its low cost, is its high relative sweetness.
Fructose is the sweetest of all naturally occurring carbohydrates.
The relative sweetness of fructose has been reported in the range of 1.2–1.8 times that of sucrose.
However, Fructose is the 6-membered ring form of fructose that is sweeter; the 5-membered ring form tastes about the same as usual table sugar.
Warming fructose leads to formation of the 5-membered ring form.
Therefore, the relative sweetness decreases with increasing temperature.
However, Fructose has been observed that the absolute sweetness of fructose is identical at 5 °C as 50 °C and thus the relative sweetness to sucrose is not due to anomeric distribution but a decrease in the absolute sweetness of sucrose at higher temperatures.

The sweetness of fructose is perceived earlier than that of sucrose or glucose, and the taste sensation reaches a peak (higher than that of sucrose), and diminishes more quickly than that of sucrose.
Fructose can also enhance other flavors in the system.

Fructose exhibits a sweetness synergy effect when used in combination with other sweeteners.
The relative sweetness of fructose blended with sucrose, aspartame, or saccharin is perceived to be greater than the sweetness calculated from individual components.

Fructose solubility and crystallization
Fructose has higher water solubility than other sugars, as well as other sugar alcohols.
Fructose is, therefore, difficult to crystallize from an aqueous solution.
Sugar mixes containing fructose, such as candies, are softer than those containing other sugars because of the greater solubility of fructose.

Fructose hygroscopicity and humectancy
Fructose is quicker to absorb moisture and slower to release it to the environment than sucrose, glucose, or other nutritive sweeteners.
Fructose is an excellent humectant and retains moisture for a long period of time even at low relative humidity (RH).
Therefore, fructose can contribute a more palatable texture, and longer shelf life to the food products in which it is used.

Freezing point
Fructose has a greater effect on freezing point depression than disaccharides or oligosaccharides, which may protect the integrity of cell walls of fruit by reducing ice crystal formation.
However, this characteristic may be undesirable in soft-serve or hard-frozen dairy desserts.

Fructose and starch functionality in food systems
Fructose increases starch viscosity more rapidly and achieves a higher final viscosity than sucrose because fructose lowers the temperature required during gelatinizing of starch, causing a greater final viscosity.
Although some artificial sweeteners are not suitable for home baking, many traditional recipes use fructose.

Uses
Fructose occurs in a large number of fruits, honey, and as the sole sugar in bull and human semen.
fructose is a naturally occurring sugar in fruits and honey.
Fructose has moisture-binding and skin-softening properties.
Fructose is a sweetener that is a monosaccharide found naturally in fresh fruit and honey. Fructose is obtained by the inversion of sucrose by means of the enzyme invertase and by the isomerization of corn syrup.
Fructose is 130–180 in sweetness range as compared to sucrose at 100 and is very water soluble.
Fructose is used in baked goods because it reacts with amino acids to produce a browning reaction.
Fructose is used as a nutritive sweetener in low-calorie beverages.
Fructose is also termed levulose and fruit sugar.

Pharmaceutical Applications
Fructose is used in tablets, syrups, and solutions as a flavoring and sweetening agent.
The sweetness-response profile of fructose is perceived in the mouth more rapidly than that of sucrose and dextrose, which may account for the ability of fructose to enhance syrup or tablet fruit flavors and mask certain unpleasant vitamin or mineral ‘off-flavors’.
The increased solubility of fructose in comparison to sucrose is advantageous in syrup or solution formulations that must be refrigerated, since settling or crystallization of ingredients is retarded.
Similarly, the greater solubility and hygroscopicity of fructose over sucrose and dextrose helps to avoid ‘cap-locking’ (sugar crystallization around the bottle cap) in elixir preparations.
Fructose also has greater solubility in ethanol (95%) and is therefore used to sweeten alcoholic formulations.

The water activity of a sweetener influences product microbial stability and freshness.
Fructose has a lower water activity and a higher osmotic pressure than sucrose.
Syrup formulations may be made at lower dry-substance levels than sugar syrups without compromising shelf-life stability.
Fructose may be necessary to include a thickener or gelling agent to match the texture or viscosity of the sugar-equivalent formulation.
Fructose is sweeter than the sugar alcohols mannitol and sorbitol, which are commonly used as tableting excipients.
Although fructose is effective at masking unpleasant flavors in tablet formulations, tablets of satisfactory hardness and friability can only be produced by direct compression if tablet presses are operated at relatively slow speeds.

However, by the combination of crystalline fructose with tablet-grade sorbitol in a 3 : 1 ratio, satisfactory direct-compression characteristics can be achieved.
A directly compressible grade of fructose, containing a small amount of starch (Advantose FS 95, SPI Pharma) is also commercially available.
Pregranulation of fructose with 3.5% povidone also produces a satisfactory tablet excipient.
(1) The added sweetness of fructose may also be used to advantage by coating the surface of chewable tablets, lozenges, or medicinal gums with powdered fructose.
The coprecipitation of fructose with hydrophobic drugs such as digoxin has been shown to enhance the dissolution profile of such drugs.
Fructose apparently acts as a water-soluble carrier upon coprecipitation, thereby allowing hydrophobic drugs to be more readily wetted.

Potential health effects
In 2022, the European Food Safety Authority stated that there is research evidence that fructose and other added free sugars may be associated with increased risk of several chronic diseases: the risk is moderate for obesity and dyslipidemia (more than 50%), and low for non-alcoholic fatty liver disease, type 2 diabetes (from 15% to 50%) and hypertension.
EFSA further stated that clinical research did "not support a positive relationship between the intake of dietary sugars, in isocaloric exchange with other macronutrients, and any of the chronic metabolic diseases or pregnancy-related endpoints assessed" but advised "the intake of added and free sugars should be as low as possible in the context of a nutritionally adequate diet."

Cardiometabolic diseases
When fructose is consumed in excess as a sweetening agent in foods or beverages, Fructose may be associated with increased risk of obesity, diabetes, and cardiovascular disorders that are part of metabolic syndrome.

Compared with sucrose
Fructose was found to increase triglycerides in type-2 but not type-1 diabetes and moderate use of Fructose has previously been considered acceptable as a sweetener for diabetics, possibly because Fructose does not trigger the production of insulin by pancreatic β cells.
For a 50 gram reference amount, fructose has a glycemic index of 23, compared with 100 for glucose and 60 for sucrose.
Fructose is also 73% sweeter than sucrose at room temperature, allowing diabetics to use less of it per serving.
Fructose consumed before a meal may reduce the glycemic response of the meal.
Fructose-sweetened food and beverage products cause less of a rise in blood glucose levels than do those manufactured with either sucrose or glucose.

Manufacturing Process
200 gal of medium containing 2% sucrose, 2% corn steep liquor solids, 0.1% potassium dihydrogen phosphate, and traces of mineral salts, was inoculated with Leuconostoc mesenteroides NRRL B-512 and incubated at 25°C.
During growth, alkali was added automatically as needed to maintain the pH between 6.6 and 7.0. Fermentation was completed in 11 hours and the culture was immediately adjusted to pH 5 to maintain enzyme stability.
Bacterial cells were removed by filtration and yielded a culture filtrate containing 40 dextransucrase units per ml, where one unit is the amount of dextransucrase which will convert 1 mg of sucrose to dextran, as determined by the amount of fructose liberated, measured as reducing power in 1 hour.

10 gal of the above culture filtrate was diluted to 40 gal with water, 33.3 lb of sucrose was added to give a 10% solution, and toluene was added as a preservative.
Dextran synthesis was complete before 22 hours, and dextran was harvested at 24 hours by the addition of alcohol to be 40% on a volume basis.
The alcoholic supernatant liquor obtained was evaporated to recover the alcohol and yielded a thick syrup, rich in fructose.
Analysis showed the syrup to contain 50.1% of reducing sugar, calculated as monosaccharide and to have an optical rotation equivalent to 35.1% fructose.
The percentages are expressed on a weight/volume basis, and reducing power was determined by the method of Somogyi, Jour. Biol. Chem. 160, 61 (1945).

A portion (4.3 liters) of the syrup was cooled to 3°C.
One-tenth of this volume was treated by slow regular addition, with rapid stirring, of a 6-fold volume of cold 20% calcium oxide suspension.
A second portion was treated in the same manner, and this process was continued until the entire volume of crude fructose syrup had been utilized.
The reaction mixture became thick with a white sediment containing a profusion of microscopic needlelike crystals of calcium levulate.
Stirring was continued for 2 hours.
The calcium levulate precipitate was separated from the reaction mixture by filtration and washed with cold water.
The precipitate was suspended in water to give a thick slurry, and solid carbon dioxide added until the solution was colorless to phenolphthalein.

A heavy precipitate of calcium carbonate was now present and free fructose remained in the solution.
The calcium carbonate precipitate was removed by filtration, and the filtered solution was found to contain 1,436 g of fructose as determined by optical rotation.
A small amount of calcium bicarbonate was present as an impurity in solution and was removed by the addition of oxalic acid solution until a test for both calcium and oxalic acid was negative.
The insoluble calcium oxalate precipitate was removed by filtration.
The fructose solution was decolorized by treatment with activated charcoal and concentrated under vacuum to a thick syrup.

Two volumes of hot 95% ethyl alcohol were added, and the solution was heated to a boil and filtered to remove a small amount of insoluble material.
After cooling, three volumes of ethyl ether were added, and the solution was allowed to stand overnight in the refrigerator.
Fructose separated from the solution as a thick syrup and was separated from the supernatant liquid by decantation.
The syrup was seeded with fructose crystals and after standing in the cold for 4 days, became a crystalline mass of fructose.
The yield of dry fructose was 928 g.
Additional recoverable quantities of fructose are present in the crystallization mother liquor.
In continuous operation this mother liquor may be recycled for addition to subsequent quantities of fructose syrup and the combined liquors crystallized as in the foregoing example.

Synonyms
D-(-)-Fructose
57-48-7
D(-)-Fructose
(3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
Nevulose
D-Levulose
DL-Fructose
30237-26-4
Furucton
Methose
D-(-)-Levulose
arabino-Hexulose
Sugar, fruit
Fructose, D-
arabino-2-Hexulose
Fructose [JAN]
Krystar 300
Hi-Fructo 970
keto-D-fructose
Fructose, pure
Advantose FS 95
CCRIS 3335
(+-)-Fructose
Fructose [USP:JAN]
EINECS 200-333-3
UNII-6YSS42VSEV
6YSS42VSEV
AI3-23514
DTXSID5023081
UNII-02T79V874P
CHEBI:48095
02T79V874P
rel-(3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
D-(-)-Fructose, >=99%
CAS-57-48-7
D-(-)fructose
MFCD00148910
alpha-Acrose
D-fructose-ring
D-Fructosa
NCGC00160604-01
Fructose (VAN)
Fructose,(S)
FUD
Fructon (TN)
D(-)-ructose
D-Fructose,(S)
pentahydroxyhexan-2-one
FRUCTOSE [INCI]
.ALPHA.-ACROSE
FRUCTOSE [FCC]
FRUCTOSE [MI]
FRUCTOSE, DL-
D-(-)-Fructose, LR
Fructose (JP17/USP)
DL-FRUCTOSE [MI]
Topiramate impurity E CRS
D02OIY
D06HZY
FRUCTOSE [WHO-DD]
SCHEMBL3965
D-(-)-Fructose, BioXtra
D-(-)-Fructose, puriss.
D-fructose (open structure)
(+/-)-FRUCTOSE
GTPL4654
CHEMBL1232863
FRUCTOSE, (+/-)-
BJHIKXHVCXFQLS-UYFOZJQFSA-N
2C6H12O6
HY-N7092
Tox21_113557
Tox21_200762
s5176
AKOS015901521
NSC 760385
GLUCOSE IMPURITY D [EP IMPURITY]
NCGC00258316-01
LS-69766
LACTULOSE IMPURITY D [EP IMPURITY]
CS-0008532
D-(-)-Fructose, for microbiology, >=99.0%
D-(-)-Fructose, tested according to Ph.Eur.
D00114
EN300-218371
A870797
D-(-)-Fructose, BioUltra, >=99.0% (HPLC)
D-(-)-Fructose, meets USP testing specifications
D-(-)-Fructose, SAJ special grade, >=98.0%
Q122043
TOPIRAMATE IMPURITY, FRUCTOSE- [USP IMPURITY]
(3S,4R,5R)-1,3,4,5,6-
DFA8C62B-E34B-4603-A548-F6A8D25645DD
Fructose, European Pharmacopoeia (EP) Reference Standard
Z1255372738
(3S,4R,5R)-1,3,4,5,6-pentakis(oxidanyl)hexan-2-one
Fructose, United States Pharmacopeia (USP) Reference Standard
D-(-)-Fructose, meets analytical specification of Ph.??Eur., BP
FRUCTOSE (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
Fructose, Pharmaceutical Secondary Standard; Certified Reference Material
D-(-)-Fructose, BioReagent, suitable for cell culture, suitable for insect cell culture
25702-76-5
D-(-)-Fructose, analytical standard, analytical standard for fructose assay kit, for use with enzymatic assay kit FA20
FRUCTOSE CRYSTAL
Fructose Crystal is a natural sugar and food additive.
Fructose Crystal is defined as a nutritive sweetener because it contains calories.
Fructose Crystal is the sweetest naturally occurring sugar and found in fruits, vegetables and honey but can be cheaply produced from sugarcane or corn.

CAS: 57-48-7
MF: C6H12O6
MW: 180.16
EINECS: 200-333-3

Fructose Crystal is a simple, six-carbon sugar like glucose and even shares the same molecular formula.
Fructose Crystal can appear as a straight chain but is expressed as two hemiacetal rings containing an alcohol and ketone group, in its crystalline form or in solution because that is a more stable arrangement.
Fructose Crystal is a pure, white, odourless solid crystal.
Fructose Crystal is a naturally occurring sweetener found in many fruits and vegetables that is about one and a half times sweeter than table sugar, with a low glycemic index.
Fructose Crystal is a monosaccharide naturally derived from a number of sources: corn and other vegetables, fruits, and honey all contain crystalline fructose.

In the production of nutritive sweeteners, the starch chains that form a slurry need to be broken down into shorter sugar units.
This results in a profile of shorter (reducing) and longer (non-reducing) sugar units.
The reducing sugars are responsible for a range of characteristics, such as sweetness, reactivity.
This profile is measured as ‘dextrose equivalent’ or ‘DE’.
In other words, DE measures the degree to which a carbohydrate is hydrolysed.
Fructose Crystal has a DE of >90.

Fructose Crystal is a monosaccharide (a single sugar molecule) but in fruits and vegetables, fructose units are bound together to form fructooligosaccharides that are broken down into fructose units.
Fructose Crystal can be extracted from fruits via membrane ultra-filtration and microwave extraction.

Fructose Crystal, is a ketonic simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose.
Fructose Crystal is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed by the gut directly into the blood of the portal vein during digestion.
The liver then converts both Fructose Crystal and galactose into glucose, so that dissolved glucose, known as blood sugar, is the only monosaccharide present in circulating blood.

Fructose Crystal was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847.
The name "fructose" was coined in 1857 by the English chemist William Allen Miller.
Pure, dry Fructose Crystal is a sweet, white, odorless, crystalline solid, and is the most water-soluble of all the sugars.
Fructose Crystal is found in honey, tree and vine fruits, flowers, berries, and most root vegetables.

Commercially, Fructose Crystal is derived from sugar cane, sugar beets, and maize.
High-fructose corn syrup is a mixture of glucose and fructose as monosaccharides.
Sucrose is a compound with one molecule of glucose covalently linked to one molecule of fructose.
All forms of fructose, including those found in fruits and juices, are commonly added to foods and drinks for palatability and taste enhancement, and for browning of some foods, such as baked goods.
As of 2004, about 240,000 tonnes of crystalline fructose were being produced annually.

Excessive consumption of sugars, including fructose, (especially from sugar-sweetened beverages) may contribute to insulin resistance, obesity, elevated LDL cholesterol and triglycerides, leading to metabolic syndrome.
The European Food Safety Authority (EFSA) stated in 2011 that Fructose Crystal may be preferable over sucrose and glucose in sugar-sweetened foods and beverages because of its lower effect on postprandial blood sugar levels, while also noting the potential downside that "high intakes of fructose may lead to metabolic complications such as dyslipidaemia, insulin resistance, and increased visceral adiposity".
The UK's Scientific Advisory Committee on Nutrition in 2015 disputed the claims of Fructose Crystal causing metabolic disorders, stating that "there is insufficient evidence to demonstrate that fructose intake, at levels consumed in the normal UK diet, leads to adverse health outcomes independent of any effects related to its presence as a component of total and free sugars."

Fructose Crystal is present as a monosaccharide in fruits and vegetables, as a disaccharide in sucrose (with D-glucose), and as oligoand polysaccharides (fructans) in many plants.
Fructose Crystal is also used as an added sweetener for food and drink, and as an excipient in pharmaceutical preparations, syrups, and solutions.
In equal amounts, Fructose Crystal is sweeter than glucose or sucrose and is therefore commonly used as a bulk sweetener.
An increase in high Fructose Crystal corn syrup, as well as total fructose, consumption over the past 10 to 20 years has been linked to a rise in obesity and metabolic disorders.
This raises concerns regarding the short and long-term effects of fructose in humans.
Fructose Crystal is present more or less frequently than glucose in the juices of plants, fruits, and especially the honey, which is about half the solid matters.

Fructose Crystal leads to an equal amount of glucose by the hydrolysis of sugar cane and a smaller proportion than some other less common sugars.
Fructose Crystal is used, such as glucose, in the production of glycogen.
Fructose Crystal enters the body through either be eaten as such or as the result of digestion of sugar cane.
Fructose Crystal is mainly changed into glycogen or triglycerides after reaching the liver, so do not enter largely in the blood circulation.
Fructose Crystal are partially inter-convertible under the influence of very dilute alkali.
Fructose Crystal is not surprising; therefore, that fructose must be converted to glycogen in the liver, which on hydrolysis yields of glucose.
Dubois et al. reported that regular consumption of sugary drinks between meals increases risk of overweight among preschool children.
Fructose Crystal has been claimed to be of concern due to several factors: First, in the 1980’s, sucrose was replaced to a large extent, particularly in North America, by high fructose corn syrup (HFCS) in carbonated beverages.

The intake of soft drinks containing HFCS has risen in parallel with the epidemic of obesity.
Second, dietary fructose has been implicated in risk factors for cardiovascular disease (CVD):
1. Plasma triglycerides (TG) and VLDL-TG increased following the ingestion of large quantities of fructose;
2. Fructose Crystal intake has been found to predict LDL particle size in overweight schoolchildren.
3. A positive relationship has been demonstrated between fructose intake and uric acid levels.
Third, the use of fructose as a sweetener has increased.
The third National Health Examination Survey (NHANES) demonstrated that over 10% of Americans’ daily calories were from fructose.
These studies suggest that the relationship between Fructose Crystal and health needs re-evaluation.

D(-)-Fructose Chemical Properties
Melting point: 119-122 °C (dec.)(lit.)
alpha: -92.25 º (c=10,H2O,on dry sub.)
Boiling point: 232.96°C (rough estimate)
density: 1.59
refractive index: -92 ° (C=4, H2O)
storage temp.: room temp
solubility H2O: 1 M at 20 °C, clear, colorless
form: Crystals or Crystalline Powder
pka: pKa (18°): 12.06
color: White
PH: 5.0-7.0 (25℃, 0.1M in H2O)
Odor: at 100.00 %. odorless
Odor Type: odorless
optical activity: [α]20/D 93.5 to 91.0°, c = 10% in H2O
Water Solubility: 3750 g/L (20 ºC)
λmax λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.04
Merck: 14,4273
BRN: 1239004
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: LKDRXBCSQODPBY-GWVKGMJFSA-N
LogP: -1.029 (est)
CAS DataBase Reference: 57-48-7(CAS DataBase Reference)
NIST Chemistry Reference: «beta»-D-Fructose(57-48-7)
EPA Substance Registry System: D-Fructose (57-48-7)

Fructose Crystal is a 6-carbon polyhydroxyketone.
Fructose Crystal adopts a cyclic six-membered structure, called β-d-fructopyranose, owing to the stability of its hemiketal and internal hydrogen-bonding.
In solution, Fructose Crystal exists as an equilibrium mixture of the tautomers β-d-fructopyranose, β-d-fructofuranose, α-d-fructofuranose, α-d-fructopyranose and keto-d-fructose (the non-cyclic form).

The distribution of Fructose Crystal tautomers in solution is related to several variables, such as solvent and temperature.
d-Fructopyranose and d-fructofuranose distributions in water have been identified multiple times as roughly 70% fructopyranose and 22% fructofuranose.

Uses
Fructose Crystal occurs in a large number of fruits, honey, and as the sole sugar in bull and human semen.
Fructose Crystal is a naturally occurring sugar in fruits and honey.
Fructose Crystal has moisture-binding and skin-softening properties.
Fructose Crystal is a sweetener that is a monosaccharide found naturally in fresh fruit and honey.
Fructose Crystal is obtained by the inversion of sucrose by means of the enzyme invertase and by the isomerization of corn syrup.
Fructose Crystal is 130–180 in sweetness range as compared to sucrose at 100 and is very water soluble.
Fructose Crystal is used in baked goods because it reacts with amino acids to produce a browning reaction.
Fructose Crystal is used as a nutritive sweetener in low-calorie beverages.
Fructose Crystal is also termed levulose and fruit sugar.

Fructose Crystal is used in tablets, syrups, and solutions as a flavoring and sweetening agent.
The sweetness-response profile of Fructose Crystal is perceived in the mouth more rapidly than that of sucrose and dextrose, which may account for the ability of fructose to enhance syrup or tablet fruit flavors and mask certain unpleasant vitamin or mineral ‘off-flavors’.
The increased solubility of Fructose Crystal in comparison to sucrose is advantageous in syrup or solution formulations that must be refrigerated, since settling or crystallization of ingredients is retarded.
Similarly, the greater solubility and hygroscopicity of fructose over sucrose and dextrose helps to avoid ‘cap-locking’ (sugar crystallization around the bottle cap) in elixir preparations.
Fructose Crystal also has greater solubility in ethanol (95%) and is therefore used to sweeten alcoholic formulations.

The water activity of a sweetener influences product microbial stability and freshness. Fructose Crystal has a lower water activity and a higher osmotic pressure than sucrose.
Syrup formulations may be made at lower dry-substance levels than sugar syrups without compromising shelf-life stability.
Fructose Crystal may be necessary to include a thickener or gelling agent to match the texture or viscosity of the sugar-equivalent formulation.
Fructose Crystal is sweeter than the sugar alcohols mannitol and sorbitol, which are commonly used as tableting excipients.
Although Fructose Crystal is effective at masking unpleasant flavors in tablet formulations, tablets of satisfactory hardness and friability can only be produced by direct compression if tablet presses are operated at relatively slow speeds.

However, by the combination of Fructose Crystal with tablet-grade sorbitol in a 3 : 1 ratio, satisfactory direct-compression characteristics can be achieved.
A directly compressible grade of Fructose Crystal, containing a small amount of starch (Advantose FS 95, SPI Pharma) is also commercially available.
Pregranulation of fructose with 3.5% povidone also produces a satisfactory tablet excipient.
(1) The added sweetness of fructose may also be used to advantage by coating the surface of chewable tablets, lozenges, or medicinal gums with powdered fructose.
The coprecipitation of Fructose Crystal with hydrophobic drugs such as digoxin has been shown to enhance the dissolution profile of such drugs.
Fructose Crystal apparently acts as a water-soluble carrier upon coprecipitation, there by allowing hydrophobic drugs to be more readily wetted.

Synonyms
D-(-)-Fructose
57-48-7
D(-)-Fructose
(3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
Nevulose
D-Levulose
DL-Fructose
30237-26-4
Furucton
Methose
D-(-)-Levulose
arabino-Hexulose
Sugar, fruit
Fructose, D-
arabino-2-Hexulose
Fructose [JAN]
Krystar 300
Hi-Fructo 970
keto-D-fructose
Fructose, pure
Advantose FS 95
CCRIS 3335
(+-)-Fructose
Fructose [USP:JAN]
EINECS 200-333-3
UNII-6YSS42VSEV
6YSS42VSEV
AI3-23514
DTXSID5023081
UNII-02T79V874P
CHEBI:48095
02T79V874P
rel-(3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
D-(-)-Fructose, >=99%
CAS-57-48-7
D-(-)fructose
MFCD00148910
alpha-Acrose
D-fructose-ring
D-Fructosa
NCGC00160604-01
Fructose (VAN)
Fructose,(S)
FUD
Fructon (TN)
D(-)-ructose
D-Fructose,(S)
pentahydroxyhexan-2-one
FRUCTOSE [INCI]
.ALPHA.-ACROSE
FRUCTOSE [FCC]
FRUCTOSE [MI]
FRUCTOSE, DL-
D-(-)-Fructose, LR
Fructose (JP17/USP)
DL-FRUCTOSE [MI]
Topiramate impurity E CRS
D02OIY
D06HZY
FRUCTOSE [WHO-DD]
SCHEMBL3965
D-(-)-Fructose, BioXtra
D-(-)-Fructose, puriss.
D-fructose (open structure)
(+/-)-FRUCTOSE
GTPL4654
CHEMBL1232863
FRUCTOSE, (+/-)-
BJHIKXHVCXFQLS-UYFOZJQFSA-N
2C6H12O6
HY-N7092
Tox21_113557
Tox21_200762
s5176
AKOS015901521
NSC 760385
GLUCOSE IMPURITY D [EP IMPURITY]
NCGC00258316-01
LS-69766
LACTULOSE IMPURITY D [EP IMPURITY]
CS-0008532
D-(-)-Fructose, for microbiology, >=99.0%
D-(-)-Fructose, tested according to Ph.Eur.
D00114
EN300-218371
A870797
D-(-)-Fructose, BioUltra, >=99.0% (HPLC)
D-(-)-Fructose, meets USP testing specifications
D-(-)-Fructose, SAJ special grade, >=98.0%
Q122043
TOPIRAMATE IMPURITY, FRUCTOSE- [USP IMPURITY]
(3S,4R,5R)-1,3,4,5,6-
DFA8C62B-E34B-4603-A548-F6A8D25645DD
Fructose, European Pharmacopoeia (EP) Reference Standard
Z1255372738
(3S,4R,5R)-1,3,4,5,6-pentakis(oxidanyl)hexan-2-one
Fructose, United States Pharmacopeia (USP) Reference Standard
D-(-)-Fructose, meets analytical specification of Ph.??Eur., BP
FRUCTOSE (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
Fructose, Pharmaceutical Secondary Standard; Certified Reference Material
D-(-)-Fructose, BioReagent, suitable for cell culture, suitable for insect cell culture
25702-76-5
D-(-)-Fructose, analytical standard, analytical standard for fructose assay kit, for use with enzymatic assay kit FA20
FUMARATE
Fumarate has a role as a food acidity regulator, a fundamental metabolite and a geroprotector.
Fumarate is the trans isomer of butenedioic acid, while maleic acid is the cis isomer.
Fumarate is a butenedioic acid in which the C=C double bond has E geometry.

CAS Number: 110-17-8
EC Number: 203-743-0
Chemical Formula: HOOCCHCHCOOH
Molar Mass: 116.07 g/mol

Fumarate is an organic compound with the formula HO2CCH=CHCO2H.
A white solid, Fumarate occurs widely in nature.

Fumarate has a fruit-like taste and has been used as a food additive.
Fumarate E number is E297.

The salts and esters are known as Fumaric acid.
Fumarate can also refer to the C4H2O2−4 ion (in solution).
Fumarate is the trans isomer of butenedioic acid, while maleic acid is the cis isomer.

Fumarate can be prepared by fermentation by employing Rhizopus species.
Recently, industrial-scale synthesis of Fumarate from renewable feedstocks and lignocellulosic biomass has been proposed

Fumarate is an organic compound (this means Fumarate consists of carbon).
The chemical formula of Fumarate is C4H4O4.

Fumarate is mostly found in Fumarate solid state and is white in color.
Fumarate has a fruit-like taste.

Fumarate is also known as Allomaleic acid.
Fumarate is a dicarboxylic acid.

Fumarate is widely used as a food additive.
Even the human skin produces Fumarate when Fumarate is exposed to sunlight.

Fumarate is a by-product of the urea cycle in human beings.
The salts and esters of Fumarate are collectively known as Fumaric acid.
Fumaric and maleic acids were discovered by Braconnet and by Vauquelin separately while they were performing the dry distillation of malic acid in the year 1817.

Fumarate appears as a colorless crystalline solid.
The primary hazard is the threat to the environment.

Immediate steps should be taken to limit spread to the environment.
Combustible, though may be difficult to ignite.
Fumarate is used to make paints and plastics, in food processing and preservation, and for other uses.

Fumarate is a butenedioic acid in which the C=C double bond has E geometry.
Fumarate is an intermediate metabolite in the citric acid cycle.

Fumarate has a role as a food acidity regulator, a fundamental metabolite and a geroprotector.
Fumarate is a conjugate acid of a Fumaric acid(1-).

Fumarate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Fumarate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Fumarate or trans-butenedioic acid, is a white crystalline chemical compound widely found in nature.
Fumarate is a key intermediate in the tricarboxylic acid cycle for organic acid biosynthesis in humans and other mammals.
Fumarate is also an essential ingredient in plant life.

When used as a food additive, the hydrophobic nature of Fumarate results in persistent, long lasting sourness and flavor impact.
The versatile compound also decreases the pH with minimal added sourness in products with pHs greater than 4.5.
Fumarate low molecular weight gives Fumarate more buffering capacity than other food acids at pHs near 3.O.

Because of Fumarate strength, less Fumarate is required when compared to other organic food acids, therefore reducing costs per unit weight.

Fumarate (C4H4O4) is an organic acid widely found in nature, and is a component of organic biosynthesis is humans.
Chemically, Fumarate is an unsaturated dicarboxylic acid.

Fumarate exists as white or nearly white crystals, odorless with a very tart taste.
Fumarate is generally nontoxic and nonirritant.

Fumarate has been used in food and beverage products since the 1940s.
Food research shows that Fumarate can improve quality and reduce the costs of many food and beverage products.

Fumarate is non-hygroscopic (absorbs no moisture).
In the cosmetic industry, Fumarate is used as a bath salt cleaning agent for dentures.

Fumarate also is used in animal feeds.
Fumarate is used in oral pharmaceutical formulations and has been used clinically in the treatment of psoriasis.
Dimethyl fumarate (Tecfidera) is the methyl ester of Fumarate, and was approved in 2013 for use in multiple sclerosis.

Fumarate is obtained from the transformation of maleic anhydride or maleic acid solutions resulting from the isomerization process (washing) of phthalic anhydride.
Fumarate application areas are unsaturated polyester resins, the acidifying animal feed and plasticized products.

Fumarate is an important specialty chemical with wide industrial applications ranging from Fumarate use as feedstock for the synthesis of polymeric resins to acidulant in foods and pharmaceuticals.
Currently, Fumarate is mainly produced by petroleum-based chemical synthesis.
Limited petroleum resources, rising oil prices, and heightened environmental concern of chemical synthesis have prompted interest in the development of bio-based Fumarate from renewable resources.

Filamentous fungal fermentation with Rhizopus spp can produce Fumarate from glucose via a reductive tricarboxylic acid (TCA) pathway and was once used in the industry before the rising of the petrochemical industry.
However, conventional Fumarate fermentation is expensive because of Fumarate low product yield and productivity.

Filamentous fungal fermentation is also difficult to operate because of Fumarate morphology.
Methods to control cell growth in the pellet form and to immobilize the mycelia in biofilm have been developed to improve fermentation performance.

Fumarate attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-Κb signaling.
Fumarate has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite.

High levels of this organic acid can be found in tumors or biofluids surrounding tumors.
Fumarate oncogenic action appears due to Fumarate ability to inhibit prolyl Hydroxylase-containing enzymes.

Fumarate (Fumaric acid, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.

Fumarate is an organic compound with the formula (COOH)CH=CH(COOH).
A white solid, Fumarate occurs widely in nature.

Fumarate has a fruit-like taste and has been used as a food additive.
Fumarate E number is E297.

Fumarate is the trans isomer of butenedioic acid, while maleic acid is the cis isomer.

Fumarate is produced naturally in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase, which is involved in ATP production.
The food grade product can be obtained by chemical synthesis or by biosynthesis.
Fumarate is used for controlling malolactic fermentation in wines under conditions stipulated by regulation.

Production by chemical synthesis is the most common:
Fumarate involves the isomerisation of maleic acid obtained from the hydrolysis of maleic anhydride, produced from the oxidation of butane or benzene. Production by biosynthesis, which is more sustainable, should develop rapidly.
Fumarate involves the fermentation by Rhizopus oryzae, in particular, of agri-food residues (e.g. from apples).

The Fumarate is prepared in solution in a volume of wine before incorporation.

Applications of Fumarate:
Fumarate has been used as a standard for the quantitative determination of phenolic compounds in nettle samples by HPLC.
Fumarate may be used in the preparation of L-Lysine-Fumarate crystals.
Fumarate may also be employed for the industrial manufacture of synthetic resins and eco-friendly/biodegradable polymers.

When used in wine, Fumarate enables you to control malolactic fermentation.
In fact, when added at an early stage after the end of alcoholic fermentation (fructose/glucose under 1 g/L), Fumarate blocks all malolactic fermentation.

Added during malolactic fermentation, Fumarate allows the fermentation to be partially completed.
Fumarate is a tool of great interest when you wish to limit [the use of SO2] or make wines without SO2.

Uses of Fumarate:
The esters of Fumarate are used for the treatment of psoriasis due to the antioxidants and anti-inflammation properties.
Fumarate is used as a food additive.

Fumarate helps preserve the taste and quality of the food products due to the low water absorption capacity of the Fumarate.
Fumarate is used by pharmacies to produce ferrous fumarate and alexipharmic.
Fumarate is used in the production of Tartaric acid.

Fumarate is related to malic acid, and, like malic acid, Fumarate is involved in the production of energy (in the form of adenosine triphosphate [ATP]) from food.

Fumarate is an essential biochemical in the cellular respiration of plants and animals.
Fumarate is used as a fortifier (paper size resins, unsaturated polyester resins, and alkyd surface coating resins), food antioxidant, dye mordant, and medication.

Fumarate is also used in dentifrices (stain remover) and to make other chemicals.
Fumarate is used in rosin esters and adducts, drying oils, printing inks, and foods (acidulant and flavoring agent).

Fumarate is used primarily in liquid pharmaceutical preparations as an acidulant and flavoring agent.
Fumarate may be included as the acid part of effervescent tablet formulations, although this use is limited as Fumarate has an extremely low solubility in water.

Fumarate is also used as a chelating agent which exhibits synergism when used in combination with other true antioxidants.
In the design of novel pelletized formulations manufactured by extrusion-spheronization, Fumarate was used to aid spheronization, favoring the production of fine pellets.

Fumarate has also been investigated as an alternative filler to lactose in pellets.
Fumarate has been investigated as a lubricant for effervescent tablets, and copolymers of Fumarate and sebacic acid have been investigated as bioadhesive microspheres.

Fumarate has also been used in film-coated pellet formulations as an acidifying agent and also to increase drug solubility.
Fumarate is also used as a food additive at concentrations up to 3600 ppm, and as a therapeutic agent in the treatment of psoriasis and other skin disorders.

Fumarate is naturally produced by the body, however for industrial applications Fumarate is synthesized chemically.
Fumarate is used to impart a tart taste to processed foods.

Fumarate is also used as an antifungal agent in boxed foods such as cake mixes and flours, as well as tortillas.
Fumarate is also added to bread to increase the porosity of the final baked product.

Fumarate is used to impart a sour taste to sourdough and rye bread.
In cake mixes, Fumarate is used to maintain a low pH and prevent clumping of the flours used in the mix.

In fruit drinks, Fumarate is used to maintain a low pH which, in turn, helps to stabilize flavor and color.
Fumarate also prevents the growth of E. coli in beverages when used in combination with sodium benzoate.

When added to wines, Fumarate helps to prevent further fermentation and yet maintain low pH and eliminate traces of metallic elements.
In this fashion, Fumarate helps to stabilize the taste of wine.

Fumarate can also be added to dairy products, sports drinks, jams, jellies and candies.
Fumarate helps to break down bonds between gluten proteins in wheat and helps to create a more pliable dough.
Fumarate is used in paper sizing, printer toner, and polyester resin for making molded walls.

Food:
Fumarate has been used as a food acidulant since 1946.
Fumarate is approved for use as a food additive in the EU, USA and Australia and New Zealand.

As a food additive, Fumarate is used as an acidity regulator and can be denoted by the E number E297.
Fumarate is generally used in beverages and baking powders for which requirements are placed on purity.

Fumarate is used in the making of wheat tortillas as a food preservative and as the acid in leavening.
Fumarate is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1 g of Fumarate to every ~1.5 g of citric acid, in order to add sourness, similarly to the way malic acid is used.
As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips, Fumarate is also used as a coagulant in stove-top pudding mixes.

The European Commission Scientific Committee on Animal Nutrition, part of DG Health, found in 2014 that Fumarate is "practically non-toxic" but high doses are probably nephrotoxic after long-term use.

Medicine:
Fumarate was developed as a medicine to treat the autoimmune condition psoriasis in the 1950s in Germany as a tablet containing 3 esters, primarily dimethyl fumarate, and marketed as Fumaderm by Biogen Idec in Europe.
Biogen would later go on to develop the main ester, dimethyl fumarate, as a treatment for multiple sclerosis.

In patients with relapsing-remitting multiple sclerosis, the ester dimethyl fumarate (BG-12, Biogen) significantly reduced relapse and disability progression in a phase 3 trial.
Fumarate activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic effects of oxidative stress.

Widespread uses by professional workers:
Fumarate is used in the following products: laboratory chemicals, adhesives and sealants, plant protection products, inks and toners and pH regulators and water treatment products. Fumarate is used in the following areas: scientific research and development, building & construction work and agriculture, forestry and fishing. Fumarate is used for the manufacture of: machinery and vehicles, furniture and electrical, electronic and optical equipment. Release to the environment of Fumarate can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of Fumarate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industrial sites:
Fumarate is used in the following products: polymers, adhesives and sealants, coating products, pharmaceuticals, inks and toners and laboratory chemicals.
Fumarate has an industrial use resulting in manufacture of another substance (use of intermediates).

Fumarate is used in the following areas: formulation of mixtures and/or re-packaging and scientific research and development.
Fumarate is used for the manufacture of: chemicals.
Release to the environment of Fumarate can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.

Industry Uses:
Agricultural chemicals (non-pesticidal)
Intermediates
Monomers
Not Known or Reasonably Ascertainable
Other (specify)
Paint additives and coating additives not described by other categories
Processing aids not otherwise specified
Processing aids, specific to petroleum production
Surface active agents
Waterproofing agent

Consumer Uses:
Fumarate is used in the following products: adhesives and sealants, coating products, inks and toners and cosmetics and personal care products.
Other release to the environment of Fumarate is likely to occur from: outdoor use and indoor use as processing aid.

Other Consumer Uses:
Agricultural chemicals (non-pesticidal)
Flavoring and nutrient
Not Known or Reasonably Ascertainable
Other (specify)

Therapeutic Uses:
Fumarate is used in oral pharmaceutical formulations and food products, and is generally regarded as a relatively nontoxic and nonirritant material.

Fumarate preparations are used as long term and effective treatment of psoriasis.

Fumarate and Fumarate esters (FAE) are already in use for treatment of psoriasis and are known to have an immunomodulatory effect.
A phase II clinical study in relapsing-remitting multiple sclerosis (RRMS) patients with the modified Fumarate ester BG-12 showed as "proof of principle" in a frequent MRI design that FAE significantly reduce the number of gadolinium-enhancing lesions after 24 weeks of treatment.
Further phase III studies have been started to explore the long-term efficacy of this substance.

Oral treatment of psoriasis on an outpatient basis, using a preparation containing Fumarate derivatives, was evaluated as initial monotherapy (3 months) and as long-term basic therapy (12-14 months) in 13 and 11 patients, respectively.
The course of the disease was analysed in each individual case.

After completion of both parts of the trial, half of the patients that had only responded poorly to conventional antipsoriatic therapy showed a significant improvement which occurred after several weeks of treatment.
In 4 patients the medication had to be stopped because of abdominal pain.

No severe side effects, particularly of renal, hepatic or hematological nature, could be established.
Studies in mice and rats disclosed only a low acute toxicity of the Fumarate derivatives used.

In additional analyses, hypotheses were dealt with concerning the mechanism of action of Fumarate in psoriasis.
To establish Fumarate derivatives in the treatment of psoriasis, studies on chronic toxicity and pharmacokinetics will have to be conducted.
Further clinical trials should evaluate a single Fumarate derivative instead of mixtures.

Other uses:
Fumarate is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes.
When Fumarate is added to their feed, lambs produce up to 70% less methane during digestion.

Industrial Processes with risk of exposure:
Pulp and Paper Processing
Painting (Pigments, Binders, and Biocides)
Textiles (Printing, Dyeing, or Finishing)

Typical Properties of Fumarate:

Physical Properties:
Fumarate mostly appears as a white-colored solid.
Fumarate has a fruit-like odor.

The molecular weight of Fumarate is 116 amu.
Fumarate is Combustible but Fumarate is difficult to start a fire.

Fumarate undergoes sublimation at 200 C.
The melting point of Fumarate is 572 to 576 °F.

Chemical Properties:
Fumarate is soluble in ethanol and concentrated sulfuric acid.
Fumarate is soluble in alcohol but is insoluble in benzene, water, and chloroform.

The capacity to absorb atmospheric moisture is very less.
The pH of Fumarate is 3.19
When Fumarate is heated in presence of Bayers reagent Fumarate gives rise to Racemic Tartaric Acid.

Characteristics of Fumarate:
One of Fumarate properties is to inhibit or block malolactic fermentation at a certain concentration.
Fumarate is therefore a tool of choice to limit the use of the SO2 previously used for this purpose.

Synthesis and Reactions of Fumarate:
Fumarate was first prepared from succinic acid.
A traditional synthesis involves oxidation of furfural (from the processing of maize) using chlorate in the presence of a vanadium-based catalyst.

Currently, industrial synthesis of Fumarate is mostly based on catalytic isomerisation of maleic acid in aqueous solutions at low pH.
Maleic acid is accessible in large volumes as a hydrolysis product of maleic anhydride, produced by catalytic oxidation of benzene or butane.

The chemical properties of Fumarate can be anticipated from Fumarate component functional groups.
This weak acid forms a diester, Fumarate undergoes additions across the double bond, and Fumarate is an excellent dienophile.

Fumarate does not combust in a bomb calorimeter under conditions where maleic acid deflagrates smoothly.
For teaching experiments designed to measure the difference in energy between the cis- and trans- isomers, a measured quantity of carbon can be ground with the subject compound and the enthalpy of combustion computed by difference.

Formula of Fumarate:
The Fumarate formula, also named as Allomaleic acid formula is discussed in this article.
Fumarate is a dicarboxylic acid and a conjugate acid of Fumaric acid.
The molecular or chemical formula of Fumarate is C4H4O4.

Fumarate is a precursor to L-malate in the TCA cycle.
Fumarate is generated by oxidizing succinic acid using succinate dehydrogenase.

Fumarate is converted to malate by the enzyme fumarase.
High levels of Allomaleic acid is present in biofluids surrounding tumours or inside the tumours.

Manufacturing Methods of Fumarate:
Commercially, Fumarate may be prepared from glucose by the action of fungi such as Rhizopus nigricans, as a by-product in the manufacture of maleic and phthalic anhydrides, and by the isomerization of maleic acid using heat or a catalyst.
On the laboratory scale, Fumarate can be prepared by the oxidation of furfural with sodium chlorate in the presence of vanadium pentoxide.

Maleic acid or maleic anhydride, especially the maleic acid-containing wash water from the production of maleic anhydride or phthalic anhydride, serves as starting material for the manufacture of Fumarate.
The maleic acid concentration should be at least 30%.

Maleic acid is converted almost quantitatively by thermal or catalytic isomerization into the sparingly soluble Fumarate, which is recovered by filtration.
Various substances have been proposed as catalysts: mineral acids (e.g., hydrochloric acid); sulfur compounds such as thiocyanates, thiazoles, thiosemicarbazides, thioureas; or bromine compounds in combination with peroxides (e.g., persulfate).

Thiourea is most commonly used in practice.
The maleic acid-containing wash water contains impurities that can affect quality and yield.

This problem can be largely avoided (1) by thermal pretreatment of the wash water, (2) by adding urea if thiourea is used as catalyst, and (3) by addition of sulfites or passaged of sulfur dioxide and addition of mineral acids.
The crude Fumarate obtained is purified by recrystallization from water, combined with purification by active charcoal.
Losses during purification are about 10%.

General Manufacturing Information of Fumarate:

Industry Processing Sectors:
Agriculture, Forestry, Fishing and Hunting
All Other Basic Organic Chemical Manufacturing
Asphalt Paving, Roofing, and Coating Materials Manufacturing
Construction
Food, beverage, and tobacco product manufacturing
Not Known or Reasonably Ascertainable
Oil and Gas Drilling, Extraction, and Support activities
Paint and Coating Manufacturing
Plastics Material and Resin Manufacturing
Textiles, apparel, and leather manufacturing

Human Metabolite Information of Fumarate:

Tissue Locations:
Placenta
Prostate

Cellular Locations:
Extracellular
Membrane
Mitochondria

Biosynthesis and Occurrence of Fumarate:
Fumarate is produced in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase.
Fumarate is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid.
In Fumarate the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z).

Fumarate is found in fumitory (Fumaria officinalis), bolete mushrooms (specifically Boletus fomentarius var. pseudo-igniarius), lichen, and Iceland moss.

Fumarate is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food.
Fumarate is formed by the oxidation of succinate by the enzyme succinate dehydrogenase.
Fumarate is then converted by the enzyme fumarase to malate.

Human skin naturally produces Fumarate when exposed to sunlight.
Fumarate is also a product of the urea cycle.

Handling and storage of Fumarate:

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage class:
Storage class (TRGS 510): 11: Combustible Solids

Stability and Reactivity of Fumarate:

Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.

The following applies in general to flammable organic substances and mixtures:
In correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability:
Fumarate is chemically stable under standard ambient conditions (room temperature).

Possibility of hazardous reactions:

Violent reactions possible with:
Oxidizing agents
Bases
Reducing agents
Amines

Conditions to avoid:
Strong heating.

Incompatible materials:
No data available

Safety of Fumarate:
Fumarate is "practically non-toxic" but high doses are probably nephrotoxic after long-term use.

First Aid Measures of Fumarate:

EYES:
First check the victim for contact lenses and remove if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.

Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN:
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital.

Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.

Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.

DO NOT INDUCE VOMITING.
IMMEDIATELY transport the victim to a hospital.

Fire Fighting of Fumarate:
Use water spray, dry powder, foam, carbon dioxide.

Fire Fighting Procedures:

If material on fire or involved in fire:
Use water in flooding quantities as fog.
Solid streams of water may spread fire.

Cool all affected containers with flooding quantities of water.
Apply water from as far a distance as possible.
Use foam, dry chemicals, or carbon dioxide.

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special protective equipment for fire-fighters:
Wear self contained breathing apparatus for fire fighting if necessary.

Accidental release measures of Fumarate:

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel:
Avoid inhalation of dusts.
Avoid substance contact.

Ensure adequate ventilation.
Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.

Observe possible material restrictions.
Take up dry.

Dispose of properly.
Clean up affected area.
Avoid generation of dusts.

Identifiers of Fumarate:
CAS Number: 110-17-8
Beilstein Reference: 605763
ChEBI: CHEBI:18012
ChEMBL: ChEMBL503160
ChemSpider: 10197150
DrugBank: DB04299
ECHA InfoCard: 100.003.404
EC Number: 203-743-0
E number: E297 (preservatives)
Gmelin Reference: 49855
KEGG: C00122
PubChem CID: 444972
RTECS number: LS9625000
UNII: 88XHZ13131
UN number: 9126
CompTox Dashboard (EPA): DTXSID3021518
InChI: InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
Key: VZCYOOQTPOCHFL-OWOJBTEDSA-N
InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
Key: VZCYOOQTPOCHFL-OWOJBTEDBF
SMILES: C(=C/C(=O)O)\C(=O)O

CAS number: 110-17-8
EC index number: 607-146-00-X
EC number: 203-743-0
Grade: ChP,NF,JPE
Hill Formula: C₄H₄O₄
Chemical formula: HOOCCHCHCOOH
Molar Mass: 116.07 g/mol
HS Code: 2917 19 80

Synonym(s): (2E)-2-Butenedioic acid, trans-Butenedioic acid
Linear Formula: HOOCCH=CHCOOH
CAS Number: 110-17-8
Molecular Weight: 116.07
Beilstein: 605763
EC Number: 203-743-0
MDL number: MFCD00002700
eCl@ss: 39021709
PubChem Substance ID: 329757345
NACRES: NA.21

Properties of Fumarate:
Chemical formula: C4H4O4
Molar mass: 116.072 g·mol−1
Appearance: White solid
Density: 1.635 g/cm3
Melting point: 287 °C (549 °F; 560 K) (decomposes)
Solubility in water: 4.9 g/L at 20 °C
Acidity (pKa): pka1 = 3.03, pka2 = 4.44 (15 °C, cis isomer)
Magnetic susceptibility (χ): −49.11·10−6 cm3/mol
Dipole moment: non zero

vapor pressure: 1.7 mmHg ( 165 °C)
Quality Level: 200
grade: purum
Assay: ≥99.0% (T)
form: powder
autoignition temp.: 1364 °F
expl. lim.: 40 %
mp: 298-300 °C (subl.) (lit.)
solubility: 95% ethanol: soluble 0.46 g/10 mL, clear, colorless
SMILES string: OC(=O)\C=C\C(O)=O
InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
InChI key: VZCYOOQTPOCHFL-OWOJBTEDSA-N

Boiling point: 290 °C (1013 hPa) (sublimed)
Density: 1.64 g/cm3 (20 °C)
Flash point: 273 °C
Ignition temperature: 375 °C
Melting Point: 287 °C
pH value: 2.1 (4.9 g/l, H₂O, 20 °C)
Vapor pressure: Solubility: 4.9 g/l

Molecular Weight: 116.07 g/mol
XLogP3: -0.3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 116.01095860 g/mol
Monoisotopic Mass: 116.01095860 g/mol
Topological Polar Surface Area: 74.6Ų
Heavy Atom Count: 8
Complexity: 119
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Fumarate:
Assay (calc. on anhydrous substance): 99.5 - 100.5 %
Assay (HPLC; calc. on anhydrous substance): 98.0 - 102.0 %
Identity (IR): passes test
Identity (JPE 1): passes test
Identity (JPE 2/ChP 1): passes test
Identity (JPE 3): passes test
Identity (HPLC): passes test
Appearance of solution: passes test
Sulfate (SO₄): ≤ 0.010 %
Heavy metals (as Pb): ≤ 10 ppm
As (Arsenic): ≤ 2 ppm
Malic acid (HPLC) (NF): ≤ 1.5 %
Maleic acid (HPLC) (NF): ≤ 0.1 %
Maleic acid (HPLC) (JPE): passes test
Maleic acid (HPLC) (ChP): ≤ 0.1 %
Any individual unspecified impurity (HPLC): ≤ 0.1 %
Sum of all impurities (HPLC): ≤ 0.2 %
Residual solvents (ICH Q3C): excluded by production process
Water (K. F.): ≤ 0.5 %
Sulfated ash: ≤ 0.05 %

Related Products of Fumarate:
Telaglenastat (CB-839)New
Setanaxib (GKT137831)New
LB-100New
Puromycin 2HCl
Cyclosporin A
Cyclophosphamide Monohydrate
Ganciclovir
Calcitriol
Ribavirin (ICN-1229)
BAPTA-AM

Related Compounds of Fumarate:
Fumaryl chloride
Fumaronitrile
Dimethyl fumarate
Ammonium fumarate
Iron(II) fumarate

Related carboxylic acids:
Maleic acid
Succinic acid
Crotonic acid

Names of Fumarate:

Regulatory process names:
Fumaric acid
Fumaric acid
fumaric acid

Translated names:
acide fumarique (fr)
acido fumarico (it)
Fumaarhape (et)
Fumaarihappo (fi)
fumaarzuur (nl)
fumarna kiselina (hr)
fumarna kislina (sl)
fumaro rūgštis (lt)
fumarová kyselina (cs)
fumarsyra (sv)
fumarsyre (da)
fumarsyre (no)
Fumarsäure (de)
fumársav (hu)
fumārskābe (lv)
kyselina fumarová (sk)
ácido fumárico (es)
ácido fumárico (pt)
φουμαρικό οξύ (el)
фумарова киселина (bg)

IUPAC names:
(2E)-but-2-enedioic acid
(E) but-2-enedioic acid
(E)-but-2-enedioic acid
(E)-Butenedioic acid
1,2-ethylene dicarboxylic acid
2-BUTENEDIOIC ACID
2-Butenedioic acid (2E)-Fumaric acid
2-Butenedioic acid, E-
acide fumarique
But-2-enedioic acid
but-2-enedioic acid
E-butenedioic Acid
FA Flakes
FUMARIC ACID
Fumaric Acid
Fumaric acid
fumaric acid
Fumaric Acid
Fumaric acid
fumaric acid
fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid
Fumarsäure
trans-1,2-Ethylenedicarboxylic
trans-2-Butenedioïc acid
trans-Butendisäure
Trans-Butenedioic Acid

Preferred IUPAC name:
(2E)-But-2-enedioic acid

Trade names:
(E)-2-Butenedioic acid
1,2-ethylene dicarboxylic acid
Allomaleic acid
Boletic acid
Butenedioic acid, (E)-
Fumaric Acid
trans-1,2-Ethylenedicarboxylic acid
TRANS-BUTENEDICARBOXYLIC ACID

Other names:
Fumaric acid
trans-1,2-Ethylenedicarboxylic acid
2-Butenedioic acid
trans-Butenedioic acid
Allomaleic acid
Boletic acid
Donitic acid
Lichenic acid

Other identifiers:
110-17-8
607-146-00-X
623158-97-4
909873-99-0

Synonyms of Fumarate:
fumaric acid
110-17-8
2-Butenedioic acid
trans-Butenedioic acid
Allomaleic acid
fumarate
Lichenic acid
Boletic acid
Tumaric acid
(2E)-but-2-enedioic acid
trans-1,2-Ethylenedicarboxylic acid
Allomalenic acid
But-2-enedioic acid
trans-2-Butenedioic acid
(E)-2-Butenedioic acid
Fumaricum acidum
2-Butenedioic acid, (E)-
Kyselina fumarova
Butenedioic acid
2-Butenedioic acid (E)-
USAF EK-P-583
Butenedioic acid, (E)-
FEMA No. 2488
(2E)-2-butenedioic acid
Caswell No. 465E
FEMA Number 2488
NSC-2752
Fumarsaeure
Allomaleic-acid
Boletic-acid
Lichenic acid (VAN)
2-Butenedioic acid (2E)-
1,2-Ethylenedicarboxylic acid, (E)
CCRIS 1039
HSDB 710
2-(E)-Butenedioic acid
Kyselina fumarova [Czech]
trans-but-2-enedioic acid
(E)-but-2-enedioic acid
U-1149
ammonium fumarate
(E)-Butenedioic acid
1,2-Ethenedicarboxylic acid, trans-
EPA Pesticide Chemical Code 051201
AI3-24236
6915-18-0
EINECS 203-743-0
fumarate, 10
BRN 0605763
Fumaric acid (NF)
Fumaric acid [NF]
INS NO.297
DTXSID3021518
UNII-88XHZ13131
CHEBI:18012
E-2-Butenedioic acid
Fumaric acid (8CI)
INS-297
NSC2752
ethylenedicarboxylic acid
FC 33 (acid)
88XHZ13131
E297
DTXCID601518
Maleic acid-2,3-13C2
E-297
2(TRANS)-BUTENEDIOIC ACID
EC 203-743-0
4-02-00-02202 (Beilstein Handbook Reference)
fum
Maleic-2,3-d2 acid
F0067
FUMARIC ACID (II)
FUMARIC ACID [II]
(E)-2-Butenedioate
Fumaric acid 1000 microg/mL in Acetonitrile:Water
FUMARIC ACID (MART.)
FUMARIC ACID [MART.]
FUMARIC ACID (USP-RS)
FUMARIC ACID [USP-RS]
(2E)-but-2-enedioate
FUMARIC ACID (USP IMPURITY)
FUMARIC ACID [USP IMPURITY]
Donitic acid
but-2-enedioicacid
CAS-110-17-8
trans-1,2-Ethenedicarboxylic acid
MALIC ACID IMPURITY A (EP IMPURITY)
MALIC ACID IMPURITY A [EP IMPURITY]
(E)-1,2-Ethylenedicarboxylic acid
trans-1,2-Ethylenediccarboxylic acid
SODIUM AUROTHIOMALATE IMPURITY B (EP IMPURITY)
SODIUM AUROTHIOMALATE IMPURITY B [EP IMPURITY]
fumarsaure
Allomaleate
Boletate
Lichenate
Acide fumarique
Acido lichenico
fumeric acid
Acido boletico
Acido fumarico
Acidum fumaricum
Acido allomaleico
trans-Butenedioate
NCGC00091192-02
24461-33-4
26099-09-2
Fumaric Acid,(S)
MFCD00002700
trans-2-Butendisaure
trans-2-Butenedioate
2-(E)-Butenedioate
Fumaric acid, 99%
Acido trans butendioico
FUM (CHRIS Code)
trans-Ethylendicarbonsaure
(Trans)-butenedioic acid
Fumaric acid, >=99%
FEMA Number: 2488
bmse000083
D03GOO
FUMARIC ACID [MI]
WLN: QV1U1VQ-T
FUMARIC ACID [FCC]
Futrans-2-Butenedioic Acid
SCHEMBL1177
FUMARIC ACID [FHFI]
FUMARIC ACID [HSDB]
FUMARIC ACID [INCI]
FUMARIC ACID [VANDF]
MLS002454406
1,2-ethylenedicarboxylic acid
2-butenedioic acid, (2E)-
(2E)-2-Butenedioic acid #
S04-0167
FUMARIC ACID [WHO-DD]
CHEMBL503160
FUMARICUM ACIDUM [HPUS]
trans-1,2-Ethylenedicarboxylate
BDBM26122
CHEBI:22958
2-Butenedioic acid (2E-(9CI)
HMS2270C12
Pharmakon1600-01301022
Fumaric acid, >=99.0% (T)
AMY30339
STR02646
Acido trans 1,2-etenedicarbossilico
Tox21_201769
Tox21_302826
2-Butenedioic acid (2E)- (9CI)
Acido trans 1,2-etilendicarbossilico
Fumaric acid, >=99%, FCC, FG
LS-500
NA9126
NSC760395
s4952
AKOS000118896
Fumaric acid, qNMR Standard for DMSO
CCG-266065
CS-W016599
DB01677
HY-W015883
NSC-760395
OR17920
USEPA/OPP Pesticide Code: 051201
NCGC00091192-01
NCGC00091192-03
NCGC00256360-01
NCGC00259318-01
BP-13087
Fumaric acid, tested according to USP/NF
SMR000112117
Fumaric acid, puriss., >=99.5% (T)
EN300-17996
Fumaric acid, Vetec(TM) reagent grade, 99%
1, (E)
C00122
D02308
D85166
Q139857
Fumaric acid, BioReagent, suitable for cell culture
J-002389
Fumarate; 2-Butenedioic acid; Trans-Butenedioic acid
Z57127460
F8886-8257
Fumaric acid, certified reference material, TraceCERT(R)
26B3632D-E93F-4655-90B0-3C17855294BA
Fumaric acid, anhydrous, free-flowing, Redi-Dri(TM), >=99%
Fumaric acid, European Pharmacopoeia (EP) Reference Standard
Fumaric acid, United States Pharmacopeia (USP) Reference Standard
Fumaric Acid, Pharmaceutical Secondary Standard; Certified Reference Material
623158-97-4
Fumaric acid [Wiki]
(2E)-2-Butendisäure [German] [ACD/IUPAC Name]
(2E)-2-Butenedioic acid [ACD/IUPAC Name]
(2E)-But-2-enedioic acid
(E)-1,2-Ethylenedicarboxylic acid
(E)-2-Butenedioic acid
(E)-Butenedioic acid
1,2-Ethenedicarboxylic acid, trans-
110-17-8 [RN]
203-743-0 [EINECS]
2-Butenedioic acid [ACD/IUPAC Name]
2-Butenedioic acid (2E)-
2-Butenedioic acid, (2E)- [ACD/Index Name]
2-Butenedioic acid, (E)-
605763 [Beilstein]
Acide (2E)-2-butènedioïque [French] [ACD/IUPAC Name]
Acidum fumaricum
Butenedioic acid, (E)-
E-2-Butenedioic acid
MFCD00002700 [MDL number]
trans-1,2-ethenedicarboxylic acid
trans-1,2-ethylenedicarboxylic acid
TRANS-2-BUTENEDIOIC ACID
trans-but-2-enedioic acid
trans-Butenedioic acid
(2E)-But-2-enedioate
(E)-2-Butenedioate
(E)-but-2-enedioate
(E)-but-2-enedioic acid
(E)-HO2CCH=CHCO2H
1,2-Ethylenedicarboxylic acid, (E)
2-(E)-Butenedioate
2-(E)-Butenedioic acid
2-Butenedioic acid (E)-
4-02-00-02202 [Beilstein]
605762 [Beilstein]
Allomalenic acid
Boletate
Boletic acid
cis-Butenedioic acid
Fumaric acidmissing
Fumaricum acidum
Fumarsaeure
Kyselina fumarova [Czech]
Lichenate
Lichenic acid (VAN)
phenanthrene-9,10-dione
phenanthrene-9,10-dione;9,10-Phenanthraquinone
QV1U1VQ-T [WLN]
STR02646
trans-1,2-Ethylenedicarboxylate
trans-1,2-Ethylentricarboxylic acid
trans-2-Butenedioate
trans-Butenedioate
延胡索酸 [Chinese]
FUMARIC ACID
Fumaric acid is an organic compound with the formula HO2CCH=CHCO2H.
A white solid, fumaric acid occurs widely in nature.
Fumaric Acid has a fruit-like taste and has been used as a food additive.
Fumaric Acid's E number is E297.


CAS Number: 110-17-8
EC Number: 203-743-0
MDL: MFCD00002700
Molecular Formula: C4H4O4 / COOH-CH=CHCOOH


Fumaric acid is an organic compound with the formula HO2CCH=CHCO2H.
A white solid, fumaric acid occurs widely in nature.
Fumaric Acid has a fruit-like taste and has been used as a food additive.


Fumaric Acid's E number is E297.
The salts and esters are known as fumarate.
Fumarate can also refer to the C4H2O2−4 ion (in solution).


Fumaric acid is the trans isomer of butenedioic acid, while maleic acid is the cis isomer.
Fumaric acid appears as a colorless crystalline solid.
Fumaric Acid is used to make paints and plastics, in food processing and preservation, and for other uses.


Fumaric acid is a butenedioic acid in which the C=C double bond has E geometry.
Fumaric Acid is an intermediate metabolite in the citric acid cycle.
Fumaric Acid has a role as a food acidity regulator, a fundamental metabolite and a geroprotector.


Fumaric Acidis a conjugate acid of a fumarate(1-).
Fumaric acid is a metabolite found in or produced by Escherichia coli.
Fumaric acid is a precursor to L-malate in the Krebs tricarboxylic acid cycle.


Fumaric Acid is formed by the oxidation of succinate by succinate dehydrogenase.
Fumarate is converted by fumarase to malate.
A fumarate is a salt or ester of the organic compound fumaric acid, a dicarboxylic acid.


Fumarate has recently been recognized as an oncometabolite.
Fumaric Acid is found in fumitory (Fumaria officinalis), bolete mushrooms (specifically Boletus fomentarius var. pseudo-igniarius), lichen, and Iceland moss.


Human skin naturally produces fumaric acid when exposed to sunlight
Fumarate is also a product of the urea cycle.
When fumaric acid is added to their feed, lambs produce up to 70% less methane during digestion.


Fumaric acid is related to malic acid, and, like malic acid, it is involved in the production of energy (in the form of adenosine triphosphate [ATP]) from food.
The chemical properties of fumaric acid can be anticipated from its component functional groups.


This weak acid, Fumaric Acid, forms a diester, it undergoes additions across the double bond, and it is an excellent dienophile.
Fumaric Acid does not combust in a bomb calorimeter under conditions where maleic acid deflagrates smoothly.
For teaching experiments designed to measure the difference in energy between the cis- and trans- isomers, a measured quantity of carbon can be ground with the subject compound and the enthalpy of combustion computed by difference.


Fumaric Acid or trans-butenedioic acid, is a white crystalline chemical compound widely found in nature.
Fumaric acid is a key intermediate in the tricarboxylic acid cycle for organic acid biosynthesis in humans and other mammals.
Fumaric acid is also an essential ingredient in plant life.


When used as a food additive, the hydrophobic nature of fumaric acid results in persistent, long lasting sourness and flavor impact.
The versatile compound also decreases the pH with minimal added sourness in products with pHs greater than 4.5.
Its low molecular weight gives fumaric acid more buffering capacity than other food acids at pHs near 3.O.


Because of its strength, less fumaric acid is required when compared to other organic food acids, therefore reducing costs per unit weight.
Fumaric Acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Fumaric acid (trans-2-butenedioic acid) is a multifunctional chemical with a diverse set of end uses, including unsaturated polyester resins (UPR), food and beverages, L-aspartic acid, rosin paper sizes, animal feed, alkyd resins, and pharmaceuticals/ferrous fumarate.
The Fumaric Acidformula, also named as Allomaleic acid formula is discussed in this article.


Fumaric Acid is a dicarboxylic acid and a conjugate acid of fumarate.
The molecular or chemical formula of Fumaric acid is C4H4O4.
Fumaric acid is a precursor to L-malate in the TCA cycle.


Fumaric Acid is generated by oxidizing succinic acid using succinate dehydrogenase.
Fumarate is converted to malate by the enzyme fumarase.
Fumaric acid is a crystalline solid which appears as colourless or white in colour.


Fumaric acid is a dicarboxylic acid.
Fumaric Acid is a precursor to L-malate in the Krebs tricarboxylic acid (TCA) cycle.
Fumaric Acid is formed by the oxidation of succinic acid by succinate dehydrogenase.


Fumarate is converted by the enzyme fumarase to malate.
Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer causing metabolite.
High levels of this organic acid can be found in tumors or biofluids surrounding tumors.


Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes.
In many tumours, oxygen availability becomes limited (hypoxia) very quickly due to rapid cell proliferation and limited blood vessel growth.
The major regulator of the response to hypoxia is the HIF transcription factor (HIF-alpha).


Under normal oxygen levels, protein levels of HIF-alpha are very low due to constant degradation, mediated by a series of post-translational modification events catalyzed by the prolyl hydroxylase domain-containing enzymes PHD1, 2 and 3, (also known as EglN2, 1 and 3) that hydroxylate HIF-alpha and lead to its degradation.


All three of the PHD enzymes are inhibited by fumarate.
Fumaric acid is found to be associated with fumarase deficiency, which is an inborn error of metabolism.
Fumaric Acid is also a metabolite of Aspergillus.


Fumaric Acid belongs to the class of organic compounds known as dicarboxylic acids and derivatives.
These are organic compounds containing exactly two carboxylic acid groups.
Fumaric acid is an organic compound ( this means it consists of carbon).


The chemical formula of fumaric acid is C4H4O4 .
Fumaric Acid is mostly found in its solid state and is white in color.
Fumaric Acid has a fruit-like taste.


Fumaric Acid is also known as Allomaleic acid.
Fumaric Acid is a dicarboxylic acid.
Even the human skin produces fumaric acid when it is exposed to sunlight.


Fumaric Acid is a by-product of the urea cycle in human beings.
The salts and esters of fumaric acid are collectively known as fumarate.
Fumaric and maleic acids were discovered by Braconnet and by Vauquelin separately while they were performing the dry distillation of malic acid in the year 1817.


Fumaric acid (C4H4O4) is an organic acid widely found in nature, and is a component of organic biosynthesis is humans.
Chemically, Fumaric Acid is an unsaturated dicarboxylic acid.
Fumaric Acid exists as white or nearly white crystals, odorless with a very tart taste.


Fumaric acid is generally nontoxic and nonirritant.
Dimethyl fumarate (Tecfidera) is the methyl ester of fumaric acid, and was approved in 2013 for use in multiple sclerosis.
Fumaric Acid is an organic acid that forms part of a number of major biochemical metabolic processes in cells, which means it is already found naturally in wine.


In the winemaking industry, Fumaric Acid is intended to be used on wine as an additive for inhibiting malolactic fermentation.
Fumaric Acid helps not only to preserve malic acid in wines but also to reduce sulphur dioxide levels and inhibit the growth and activity of lactic acid bacteria.
Fumaric Acid comes in the form of a fine, odourless, mixed grain powder.


Fumaric Acid is much less soluble when compared to other organic acids of oenological interest.
Fumaric acid is an organic acid that serves a variety of functional purposes, including enhancing taste, managing pH, reducing hygroscopicity, improving shelf stability, and more.
Fumaric acid is a functional ingredient that is applicable across food, beverage, animal nutrition, industrial, pharmaceutical, and personal care markets.



USES and APPLICATIONS of FUMARIC ACID:
As a food additive, Fumaric Acid is used to impart a tart taste to processed foods.
Fumaric Acid is also used as an antifungal agent in boxed foods such as cake mixes and flours, as well as tortillas.
Fumaric acid is also added to bread to increase the porosity of the final baked product.


Fumaric Acid is used to impart a sour taste to sourdough and rye bread.
In cake mixes, Fumaric Acid is used to maintain a low pH and prevent clumping of the flours used in the mix.
In fruit drinks, Fumaric Acid is used to maintain a low pH which, in turn, helps to stabilize flavor and color.


Fumaric acid also prevents the growth of E. coli in beverages when used in combination with sodium benzoate.
When added to wines, fumaric acid helps to prevent further fermentation and yet maintain low pH and eliminate traces of metallic elements.
In this fashion, Fumaric Acid helps to stabilize the taste of wine.


Fumaric acid can also be added to dairy products, sports drinks, jams, jellies and candies.
Fumaric acid helps to break down bonds between gluten proteins in wheat and helps to create a more pliable dough.
Fumaric acid is used in paper sizing, printer toner, and polyester resin for making molded walls.


Other uses of Fumaric Acid: Fumaric acid is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes.
Fumaric Acid is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


Release to the environment of Fumaric Acid can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, of substances in closed systems with minimal release and in the production of articles.


Fumaric Acid is used in the following products: adhesives and sealants, coating products, inks and toners and cosmetics and personal care products.
Other release to the environment of Fumaric Acid is likely to occur from: outdoor use and indoor use as processing aid.
Fumaric Acid can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).


Fumaric Acid is used in the following products: laboratory chemicals, adhesives and sealants, plant protection products, inks and toners and pH regulators and water treatment products.
Fumaric Acid is used in the following areas: scientific research and development, building & construction work and agriculture, forestry and fishing.


Fumaric Acid is used for the manufacture of: machinery and vehicles, furniture and electrical, electronic and optical equipment.
Release to the environment of Fumaric Acid can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).


Fumaric Acid is used in the following products: non-metal-surface treatment products, pH regulators and water treatment products, leather treatment products, plant protection products, polishes and waxes, cosmetics and personal care products, adhesives and sealants, coating products, inks and toners and pharmaceuticals.


Release to the environment of Fumaric Acid can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles.
Other release to the environment of Fumaric Acid is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).


Other release to the environment of Fumaric Acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Fumaric Acid is used in the following products: polymers, adhesives and sealants, coating products, pharmaceuticals, inks and toners and laboratory chemicals.


Fumaric Acid has an industrial use resulting in manufacture of another substance (use of intermediates).
Fumaric Acid is used in the following areas: formulation of mixtures and/or re-packaging and scientific research and development.
Fumaric Acid is used for the manufacture of: chemicals.


Release to the environment of Fumaric Acid can occur from industrial use: manufacturing of the substance, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and of substances in closed systems with minimal release.


Release to the environment of Fumaric Acid can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.
Fumaric Acid is used as a seasoning, because E297 is the organic acid sourest taste.


Fumaric Acid is mainly used in the processing of meat products and fish products in food.
Fumaric acid can be used as acidity regulator, acidulant, antioxidant aid, pickling accelerator and spice.
Fumaric Acid has a strong buffering effect to keep the pH of the aqueous solution around 3.0, and plays an important role in inhibiting bacteria and mildew.


Fumaric Acid is widely used to make paints, plastics, in food processing and preserving, etc.
Fumaric Acid is used in the field of medicine and other uses such as mordant for dyes.
The esters of Fumaric acid are used for the treatment of psoriasis due to the antioxidants and anti-inflammation properties.


Fumaric acid is used as a food additive.
Fumaric Acid helps preserve the taste and quality of the food products due to the low water absorption capacity of the Fumaric acid.
Fumaric acid is used by pharmacies to produce ferrous fumarate and alexipharmic.


Fumaric acid is used in the production of Tartaric acid.
One of Fumaric Acid's properties is to inhibit or block malolactic fermentation at a certain concentration.
Fumaric Acid is therefore a tool of choice to limit the use of the SO2 previously used for this purpose.


When used in wine, Fumaric Acid enables you to control malolactic fermentation.
In fact, when added at an early stage after the end of alcoholic fermentation (fructose/glucose under 1 g/L), Fumaric Acid blocks all malolactic fermentation.


Added during malolactic fermentation, Fumaric Acid allows the fermentation to be partially completed.
Fumaric Acid is a tool of great interest when you wish to limit [the use of SO2] or make wines without SO2.
Fumaric Acid is widely used as a food additive.


Fumaric acid has been used in food and beverage products since the 1940s.
Food research shows that fumaric acid can improve quality and reduce the costs of many food and beverage products.
Fumaric Acid is non-hygroscopic (absorbs no moisture).


In the cosmetic industry, Fumaric Acid is used as a bath salt cleaning agent for dentures.
Fumaric Acid also is used in animal feeds.
Fumaric acid is used in oral pharmaceutical formulations and has been used clinically in the treatment of psoriasis.


Fumaric Acid is widely believed to effectively inhibit malolactic fermentation: existing bibliography describes Fumaric Acid as being efficient in preventing its microbiological onset and in blocking it once it has already started.
All of these interesting aspects make Fumaric Acid suitable for all vinification operations in which sulphur levels need to be contained.


For instance, Fumaric Acid is ideal for making sparkling wine bases, but also for making fine white, rosé or red wines, for those seeking the pleasant taste that malic acidity offers.
When dosed as recommended, Fumaric Acid causes a reduction in pH of approximately 1 to 2 tenths, depending on the wine’s buffer capacity, and increases total acidity compared to what would happen if tartaric acid were added.


However, according to current legislation, it is not classified as an acidifier, which means that it can be used even though Fumaric Acid is not included in the relevant register.
The effect of Fumaric Acid persists for as long as the molecule is present in the medium: for example, it has been observed to last for many months when added to wine once the fermentation process is complete, during refinement without Saccharomyces cerevisiae activity.


Before using Fumaric Acid, orientation tests should be carried out in the laboratory in order to be able to predict its effects on the sensory balance of the wine.
Fumaric Acid is the perfect complement in wine production lines for making wines without added sulphur dioxide.


Fumaric Acid is poorly soluble in water; the situation improves slightly in a hydroalcoholic solution and by raising the temperature, but not sufficiently enough.
Consequently, Fumaric Acid is advisable to prepare a solution directly on wine in a 1:10 ratio and to then homogeneously incorporate this preparation into the mass to be treated, without having to prepare a solution in water.


Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-Κb signaling.
Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite.
High levels of Fumaric Acid can be found in tumors or biofluids surrounding tumors.


Fumaric Acid's oncogenic action appears due to its ability to inhibit prolyl Hydroxylase-containing enzymes.
Fumaric acid has been used in food and beverage products for almost a century and is most commonly relied on to improve quality and reduce costs of many food, beverage, and animal feed products.


An effective tool for balancing the pH in food and beverages, fumaric acid controls the impact and intensity of sourness and flavor as well as having an anti-microbial and bactericidal effect.
Fumaric acid is completely non-hygroscopic, keeping powdered mixes from caking and hardening from moisture.


Fumaric Acid is also stronger than other acids, enabling the use of less product to achieve the same results–thereby improving economies by lowering ingredient cost.


-Food uses of Fumaric Acid:
Fumaric acid has been used as a food acidulant since 1946.
Fumaric Acid is approved for use as a food additive in the EU,[6] USA and Australia and New Zealand.

As a food additive, Fumaric Acid is used as an acidity regulator and can be denoted by the E number E297.
Fumaric Acid is generally used in beverages and baking powders for which requirements are placed on purity.
Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening.

Fumaric Acid is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1 g of fumaric acid to every ~1.5 g of citric acid, in order to add sourness, similarly to the way malic acid is used.
As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips, Fumaric Acid is also used as a coagulant in stove-top pudding mixes.


-Medicine uses of Fumaric Acid:
Fumaric acid was developed as a medicine to treat the autoimmune condition psoriasis in the 1950s in Germany as a tablet containing 3 esters, primarily dimethyl fumarate, and marketed as Fumaderm by Biogen Idec in Europe.
Biogen would later go on to develop the main ester, dimethyl fumarate, as a treatment for multiple sclerosis.

In patients with relapsing-remitting multiple sclerosis, the ester dimethyl fumarate (BG-12, Biogen) significantly reduced relapse and disability progression in a phase 3 trial.
It activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic effects of oxidative stress.



FUNCTIONS AND APPLICATIONS OF FUMARIC ACID:
1. Fumaric Acid used as a seasoning, because E297 is the organic acid sourest taste.
Fumaric Acid three parts are as sour as the five parts of citric acid.

2. Fumaric Acid but also as an antioxidant, mordant (a substance that helps the dye adhere to fabric), and as a buffer (to help maintain a particular acidity or alkalinity).

3. Fumaric Acid is used to lower the pH (acid to make more things, which taste more sour).
This helps to a certain degree of anti-microbial agents, such as better work.
Fumaric Acid itself to kill bacteria.

4. Fumaric Acid break the bread dough the elastic protein gluten of the sulfur-sulfur bond.
This makes the dough more machinable.
Fumaric Acid is in the use of rye bread and yeast, making them more acid.

5. Fumaric Acid combined with leavening agent (carbon dioxide gas produced carbin to make bread rise) to create slow.
Because Fumaric Acid is only dissolved in warm water, leavening action postponed to start baking bread.

6. Fumaric Acid is also used to produce unsaturated polyester resins.



SYNTHESIS AND REACTIONS OF FUMARIC ACID:
Fumaric acid was first prepared from succinic acid.
A traditional synthesis involves oxidation of furfural (from the processing of maize) using chlorate in the presence of a vanadium-based catalyst.
Currently, industrial synthesis of fumaric acid is mostly based on catalytic isomerisation of maleic acid in aqueous solutions at low pH.
Maleic acid is accessible in large volumes as a hydrolysis product of maleic anhydride, produced by catalytic oxidation of benzene or butane.



ALTERNATIVE PARENTS OF FUMARIC ACID:
*Unsaturated fatty acids
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF FUMARIC ACID:
*Fatty acyl
*Fatty acid
*Unsaturated fatty acid
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



BIOSYNTHESIS AND OCCURRENCE OF FUMARIC ACID:
Fumaric Acid is produced in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase.
Fumaric Acid is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid.
In Fumaric Acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z).



RELATED CARBOXYLIC ACIDS OF FUMARIC ACID:
*Maleic acid
*Succinic acid
*Crotonic acid



PREPARATION METHOD OF FUMARIC ACID:
Fumaric acid is produced by the isomerization of maleic acid.
In this reaction catalyst such as mineral, and acid is used.
Fumaric acid can be prepared by heating dilute Bromo succinic Acid in the presence of KOH.
Fumaric acid can be prepared by reduction of tartaric acid in presence of phosphorus and iodine.
Fumaric acid can be prepared by heating bromosuccinic acid with water.
Fumaric Acid can be prepared by heating Maleic acid above 200 0 C.



STRUCTURE OF FUMARIC ACID:
Fumaric Acid is made up of Carbon, Hydrogen, and oxygen.
The chemical formula fumaric acid is C4H4O4 .
Fumaric Acid is mostly found in its solid state and is white in color.

Fumaric Acid is also known as Allomaleic acid.
Fumaric Acid is a dicarboxylic acid.
The IUPAC name of Fumaric acid is (E)-Butenedioic acid.

Fumaric acid is the trans-isomer of butenedioic acid.
Fumaric Acid has a Carbon-carbon double bond.
The geometry of this molecular is E.
The molecular weight of Fumaric acid is 116 amu.



RELATED COMPOUNDS OF FUMARIC ACID:
*Fumaryl chloride
*Fumaronitrile
*Dimethyl fumarate
*Ammonium fumarate
*Iron(II) fumarate



PHYSICAL PROPERTIES OF FUMARIC ACID:
Fumaric Acid mostly appears as a white-colored solid.
Fumaric Acid has a fruit-like odor.
The molecular weight of Fumaric acid is 116 amu.

Fumaric acid is Combustible but it is difficult to start a fire.
Fumaric acid undergoes sublimation at 200 C.
The melting point of Fumaric acid is 572 to 576 °F.
Chemical Properties of Fumaric Acid

Fumaric acid is soluble in ethanol and concentrated sulfuric acid.
It is soluble in alcohol but is insoluble in benzene, water, and chloroform.
The capacity of Fumaric Acid to absorb atmospheric moisture is very less.
The pH of Fumaric acid is 3.19

When Fumaric acid is heated in presence of Bayers reagent it gives rise to Racemic Tartaric Acid.
Fumaric Acid on Bromination gives 2,3-dibromosuccinic acid.
When Fumaric acid is heated in a closed vessel with water at a temperature of almost 150 – 170 °C it produces DL-malic acid.
When Fumaric acid and methanol are heated in the presence of Sulfuric acid it gives rise to Dimethyl fumarate.



WHAT ARE FUMARIC ACID ESTERS?
The fumaric acid esters (FAE) monoethyl fumarate (MEF) and dimethyl fumarate (DMF) are chemical compounds derived from the base compound fumaric acid.
Fumaric acid is a food additive commonly found in sweets and cakes. In this chemical state, fumaric acid is poorly absorbed and passes straight through the body without causing any effects.

On the other hand, fumaric acid esters are potent chemicals or drugs that have been used to treat psoriasis for over 30 years.
However, it is only within the last decade that serious clinical research has been carried out to determine their use, effectiveness and safety in the treatment of psoriasis and other skin conditions.

It is important to emphasise the difference between fumaric acid and fumaric acid esters. Fumaric acid formulations are available as health supplements and often marketed as a natural alternative medicine to treat psoriasis.
They are poorly absorbed by the gut and excreted via urine without having any therapeutic effect whatsoever.



WHAT IS THE HISTORY OF FUMARIC ACID ESTERS?
The use of fumaric acid esters in the treatment of psoriasis was first introduced in the late 1950s by the German chemist Schweckendiek.
A standardised fumaric acid protocol for psoriasis was developed and used FAEs both orally and topically (ointment and bathing solution).
Results were promising but were associated with serious side effects.

At that time it was thought that psoriasis was caused by a biochemical defect of the citric acid (Krebs) cycle, of which fumaric acid plays a role.
Although the mode of action of FAEs and their place in psoriasis therapy remains unclear, evidence suggests that it has nothing to do with the Krebs cycle and the major active compound appears to be dimethyl fumarate (DMF).
This is thought to work by correcting the immunological imbalance that exists in psoriasis (shifting from a Th1 pattern of immune response to a Th2 one).



WHO USES FUMARIC ACID ESTERS?
Fumaric acid esters have been used to treat severe psoriasis in northern Europe for over 20 years.
Many recent studies have shown that FAEs is an effective therapy in patients with severe psoriasis who have tried and failed conventional psoriasis treatments.

Patients tolerating FAE therapy can expect a 75% improvement in their psoriasis in four months.
Also, FAEs are being used in combination with second-line drugs such as ciclosporin, methotrexate and hydroxyurea for an additional benefit or to facilitate dose reduction of the second line agent.



PHYSICAL and CHEMICAL PROPERTIES of FUMARIC ACID:
Molecular Weight: 116.07 g/mol
XLogP3: -0.3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 116.01095860 g/mol
Monoisotopic Mass: 116.01095860 g/mol
Topological Polar Surface Area: 74.6Ų
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 119
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Weight: 116.07
Melting Point: 287 °C
Boiling Point: 156 °C
Physical state: solid
Color: No data available
Odor: No data available
Melting point/freezing point:
Melting point/range: 298 - 300 °C


Initial boiling point and boiling range: 290 °C at 1.013 hPa - (sublimed)
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 273 °C - DIN 51758
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,64 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Appearance: white colorless crystalline powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: Yes
Melting Point: 298.00 to 300.00 °C. @ 760.00 mm Hg
Boiling Point: 156.00 °C. @ 1.70 mm Hg
Vapor Pressure: 0.000005 mmHg @ 25.00 °C. (est)

CAS number: 110-17-8
EC index number: 607-146-00-X
EC number: 203-743-0
Hill Formula: C₄H₄O₄
Chemical formula: HOOCCHCHCOOH
Molar Mass: 116.07 g/mol
HS Code: 2917 19 80
Boiling point: 290 °C (1013 hPa) (sublimed)
Density: 1.64 g/cm3 (20 °C)
Flash point: 273 °C
Ignition temperature: 375 °C
Melting Point: 287 °C
pH value: 2.1 (4.9 g/l, H₂O, 20 °C)
Vapor pressure: Solubility: 4.9 g/l
Chemical formula: C4H4O4
Molar mass: 116.072 g·mol−1
Appearance: White solid
Density: 1.635 g/cm3
Melting point: 287 °C (549 °F; 560 K)
Solubility in water: 4.9 g/L at 20 °C
Acidity (pKa): pka1 = 3.03, pka2 = 4.44 (15 °C, cis isomer)
Magnetic susceptibility (χ): −49.11·10−6 cm3/mol
Dipole moment: non zero

Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 0.460
Soluble in:
alcohol
oils, slightly
water, 1.042e+005 mg/L @ 25 °C (est)
water, 7000 mg/L @ 25 °C (exp)
Chemical Formula: C4H4O4
Average Molecular Weight: 116.0722
Monoisotopic Molecular Weight: 116.010958616
IUPAC Name: (2E)-but-2-enedioic acid
Traditional Name: fumaric acid
CAS Registry Number: 110-17-8
SMILES: OC(=O)\C=C\C(O)=O
InChI Identifier: InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
InChI Key: VZCYOOQTPOCHFL-OWOJBTEDSA-N
Molar Weight: 116.07 g/mol
Melting Point: 287.0°C
Boiling Point: 522 °C
Flash Point: 230.0°C
Min. Purity Spec: 99% (HPLC)
Physical Form (at 20°C): Solid
Melting Point: 131-133°C

Density: 1.6
Long-Term Storage: Store long-term in a cool, dry place
Water Solubility: 24.1 g/L
logP: 0.21
logP: -0.041
logS: -0.68
pKa (Strongest Acidic): 3.55
Physiological Charge: -2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 2
Polar Surface Area: 74.6 Ų
Rotatable Bond Count: 2
Refractivity: 24.61 m³·mol⁻¹
Polarizability: 9.35 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
Chemical formula: C4H4O4
Molecular weight: 116.072 g/mol
Density: 1.635 g/cm3
Boiling point: White solid
Melting point: 287 °C

Chemical formula: C4H4O4
(COOH)CH=CH(COOH)
Molar mass: 116.072 g/mol
Odor: Odorless
Density: 1.635 g/cm3 (20 °C)
Melting point: 287 °C (549 °F; 560 K) (decomposition)
Boiling point: Decomposes
Solubility in water:
0.49 g/100 ml (20 °C)
0.70 g/100 ml (25 °C)
1.07 g/100 ml (40 °C)
2.40 g/100 ml (60 °C)
9.80 g/100 ml (100 °C)
Solubility: Soluble in alcohols
Solubility in acetone: 1.29 g/100 ml (20 °C)
1.72 g/100 ml (29.7 °C)
Solubility in benzene: 0.003 g/100 ml (25 °C)
Solubility in carbon tetrachloride: 0.027 g/100 ml (25 °C)
Solubility in chloroform: 0.02 g/100 ml (25 °C)
Solubility in diethyl ether: 1.01 g/100 ml (25 °C)
Vapor pressure: 1.54·10-4 mmHg at 25 °C
Acidity (pKa): pKa1= 3.03
pKa2= 4.44
Thermochemistry
Std molar entropy (So298): 168 J·mol−1·K−1
Std enthalpy of formation (ΔfHo298): -811.7 kJ/mol

Melting Point: 295.0°C to 300.0°C
Color: White
Density: 1.6200g/mL
Flash Point: 230°C
Infrared Spectrum: Authentic
Linear Formula: HO2CCH=CHCO2H
Beilstein: 02, IV, 2202
Fieser: 05,319
Merck Index: 15, 4316
Specific Gravity: 1.62
Solubility Information: Solubility in water: 6.3g/l (25°C).
Other solubilities: 0.72g/100g ether (25°C)- 1.72g/100g acetone,
(30°C)- 5.76g/100 g 95% alcohol (30°C),
practically insoluble in chloroform,carbon tetra-,chloride and benzene
IUPAC Name: (2E)-but-2-enedioic acid
Formula Weight: 116.07
Percent Purity: 99+%
Physical Form: Fine Crystalline Powder
Chemical Name or Material: Fumaric acid



FIRST AID MEASURES of FUMARIC ACID:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Rresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of FUMARIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.


FIRE FIGHTING MEASURES of FUMARIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FUMARIC ACID:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FUMARIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of FUMARIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available



SYNONYMS:
fumaric acid
110-17-8
2-Butenedioic acid
trans-Butenedioic acid
Allomaleic acid
fumarate
Lichenic acid
Boletic acid
Tumaric acid
(2E)-but-2-enedioic acid
trans-1,2-Ethylenedicarboxylic acid
Allomalenic acid
But-2-enedioic acid
trans-2-Butenedioic acid
(E)-2-Butenedioic acid
Fumaricum acidum
2-Butenedioic acid, (E)-
Kyselina fumarova
Butenedioic acid
2-Butenedioic acid (E)-
USAF EK-P-583
Butenedioic acid, (E)-
FEMA No. 2488
(2E)-2-butenedioic acid
Caswell No. 465E
FEMA Number 2488
NSC-2752
trans-butenedioic acid
Boletic acid
Bbut-2-enedioic acid
Butene dioic acid
Butenedioic acid
1,2-ethylene dicarboxylic acid
Alpha,beta- ethylene-1,2-dicarboxylic acid
1,2-ethylenedicarboxylic acid
Lichenic acid
allo maleic acid
allo-maleic acid
allo-malenic acid
Tumaric acid
1,2-Ethenedicarboxylic acid, trans-
Allomaleic acid
Tumaric acid
2-Butenedioic acid
trans-Butenedioic acid
Allomaleic acid
Boletic acid
Lichenic acid
Boletic acid
Allomaleic acid
Trans-butenedioic acid
Trans-1,2-Ethylenedicarboxylic acid
2 - Butenedioic Acid
Allomaleic Acid
Boleic Acid
E 297
Lichenic Acid
trans - Butenedioic Acid
Trans Isomer of Maleic Acid
(2E)-2-Butenedioic acid
(2E)-But-2-enedioate
(2E)-But-2-enedioic acid
(E)-2-Butenedioate
(E)-2-Butenedioic acid
(E)-2-butenedioic acid, ion(2-)
(E)-HO2CCH=CHCO2H
1, 2-Ethenedicarboxylic acid, trans-
1,2-Ethenedicarboxylic acid, trans-
1,2-Ethylenedicarboxylic acid, (E)
2-(E)-Butenedioate
2-(E)-Butenedioic acid
2-butenedioic acid
2-Butenedioic acid (E)-
2-Butenedioic acid, (E)-
Allomaleate
Allomaleic acid
Boletate
Boletic acid
Butenedioic acid, (E)-
Fumarate
Fumaric acid
Kyselina fumarova
Lichenate
Lichenic acid
sodium fumarate
trans-1,2-Ethylenedicarboxylate
trans-1,2-Ethylenedicarboxylic acid
trans-2-Butenedioate
trans-2-Butenedioic acid
trans-Butenedioate
trans-Butenedioic acid
Tumaric acid
e297
Fumarsaeure
trans-But-2-enedioic acid
(2E)-2-Butenedioate
trans-But-2-enedioate
FC 33
Furamag
Mafusol
Fumarsaeure
Allomaleic-acid
Boletic-acid
Lichenic acid (VAN)
2-Butenedioic acid (2E)-
1,2-Ethylenedicarboxylic acid, (E)
CCRIS 1039
HSDB 710
2-(E)-Butenedioic acid
Kyselina fumarova [Czech]
trans-but-2-enedioic acid
(E)-but-2-enedioic acid
U-1149
ammonium fumarate
(E)-Butenedioic acid
1,2-Ethenedicarboxylic acid, trans-
EPA Pesticide Chemical Code 051201
AI3-24236
6915-18-0
EINECS 203-743-0
fumarate, 10
BRN 0605763
Fumaric acid (NF)
Fumaric acid [NF]
INS NO.297
DTXSID3021518
UNII-88XHZ13131
CHEBI:18012
E-2-Butenedioic acid
Fumaric acid (8CI)
INS-297
NSC2752
ethylenedicarboxylic acid
FC 33 (acid)
88XHZ13131
E297
DTXCID601518
Maleic acid-2,3-13C2
E-297
2(TRANS)-BUTENEDIOIC ACID
EC 203-743-0
4-02-00-02202 (Beilstein Handbook Reference)
fum
Maleic-2,3-d2 acid
F0067
FUMARIC ACID (II)
FUMARIC ACID [II]
(E)-2-Butenedioate
Fumaric acid 1000 microg/mL in Acetonitrile:Water
FUMARIC ACID (MART.)
FUMARIC ACID [MART.]
FUMARIC ACID (USP-RS)
FUMARIC ACID [USP-RS]
(2E)-but-2-enedioate
FUMARIC ACID (USP IMPURITY)
FUMARIC ACID [USP IMPURITY]
Donitic acid
but-2-enedioicacid
CAS-110-17-8
trans-1,2-Ethenedicarboxylic acid
MALIC ACID IMPURITY A (EP IMPURITY)
MALIC ACID IMPURITY A [EP IMPURITY]
(E)-1,2-Ethylenedicarboxylic acid
trans-1,2-Ethylenediccarboxylic acid
SODIUM AUROTHIOMALATE IMPURITY B (EP IMPURITY)
SODIUM AUROTHIOMALATE IMPURITY B [EP IMPURITY]
fumarsaure
Allomaleate
Boletate
Lichenate
Acide fumarique
Acido lichenico
fumeric acid
Acido boletico
Acido fumarico
Acidum fumaricum
Acido allomaleico
trans-Butenedioate
NCGC00091192-02
24461-33-4
26099-09-2
Fumaric Acid,(S)
MFCD00002700
trans-2-Butendisaure
trans-2-Butenedioate
2-(E)-Butenedioate
Fumaric acid, 99%
Acido trans butendioico
FUM (CHRIS Code)
trans-Ethylendicarbonsaure
(Trans)-butenedioic acid
Fumaric acid, >=99%
FEMA Number: 2488
bmse000083
D03GOO
FUMARIC ACID [MI]
WLN: QV1U1VQ-T
FUMARIC ACID [FCC]
Futrans-2-Butenedioic Acid
SCHEMBL1177
FUMARIC ACID [FHFI]
FUMARIC ACID [HSDB]
FUMARIC ACID [INCI]
FUMARIC ACID [VANDF]
MLS002454406
1,2-ethylenedicarboxylic acid
2-butenedioic acid, (2E)-
(2E)-2-Butenedioic acid #
S04-0167
FUMARIC ACID [WHO-DD]
CHEMBL503160
FUMARICUM ACIDUM [HPUS]
trans-1,2-Ethylenedicarboxylate
BDBM26122
CHEBI:22958
2-Butenedioic acid (2E-(9CI)
HMS2270C12
Pharmakon1600-01301022
Fumaric acid, >=99.0% (T)
AMY30339
STR02646
Acido trans 1,2-etenedicarbossilico
Tox21_201769
Tox21_302826
2-Butenedioic acid (2E)- (9CI)
Acido trans 1,2-etilendicarbossilico
Fumaric acid, >=99%, FCC, FG
LS-500
NA9126
NSC760395
s4952
AKOS000118896
Fumaric acid, qNMR Standard for DMSO
CCG-266065
CS-W016599
DB01677
HY-W015883
NSC-760395
OR17920
USEPA/OPP Pesticide Code: 051201
NCGC00091192-01
NCGC00091192-03
NCGC00256360-01
NCGC00259318-01
BP-13087
Fumaric acid, tested according to USP/NF
SMR000112117
Fumaric acid, puriss., >=99.5% (T)
EN300-17996
Fumaric acid, Vetec(TM) reagent grade, 99%
C00122
D02308
D85166
Q139857
Fumaric acid, BioReagent, suitable for cell culture
J-002389
Fumarate
2-Butenedioic acid
Trans-Butenedioic acid
Z57127460
F8886-8257
Fumaric acid, certified reference material, TraceCERT(R)
26B3632D-E93F-4655-90B0-3C17855294BA
Fumaric acid, anhydrous, free-flowing, Redi-Dri(TM), >=99%
Fumaric acid, European Pharmacopoeia (EP) Reference Standard
Fumaric acid, United States Pharmacopeia (USP) Reference Standard
Fumaric Acid, Pharmaceutical Secondary Standard; Certified Reference Material
623158-97-4
2-Butenedioic acid (E)-
trans-Butenedioic Acid
trans-1,2-Ethylenedicarboxylic Acid
Allomaleic acid
Boletic acid
Lichenic acid
Tumaric acid
(E)-2-Butenedioic acid
(E)-HO2CCH=CHCO2H
Butenedioic acid, (E)-
NSC-2752
U-1149
USAF EK-P-583
1,2-Ethenedicarboxylic acid, trans-
1,2-Ethylenedicarboxylic acid, (E)
2-Butenedioic acid (2E)-
(2E)-But-2-enedioic acid
Fumaric acid
trans-1,2-Ethylenedicarboxylic acid
2-Butenedioic acid
trans-Butenedioic acid
Allomaleic acid
Boletic acid
Donitic acid
Lichenic acid
ALLOMALEIC ACID
BOLETIC ACID
(E)-BUTENEDIOIC ACID
(E)-1,2-ETHYLENEDICARBOXYLIC ACID
(2E)-2-Butenedioic acid
(e)-2-Butenedioic acid
e297
Fumarsaeure
trans-1,2-Ethylenedicarboxylic acid
trans-But-2-enedioic acid
trans-Butenedioic acid
(2E)-2-Butenedioate
(e)-2-Butenedioate
trans-1,2-Ethylenedicarboxylate
trans-But-2-enedioate
trans-Butenedioate
Fumarate
(2E)-But-2-enedioate
(2E)-But-2-enedioic acid
2-(e)-Butenedioate
2-(e)-Butenedioic acid
Allomaleate
Allomaleic acid
Boletate
Boletic acid
FC 33
Lichenate
Lichenic acid
trans-2-Butenedioate
trans-2-Butenedioic acid
Furamag
Mafusol
Fumaric acid
(2E)-But-2-enedioic acid
2-Butenedioic acid
Allomaleic acid
Boletic acid
Donitic acid
E297
Lichenic acid
trans-1,2-Ethylenedicarboxylic acid
trans-Butenedioic acid



FUMARIC ACID
SYNONYMS 2-Butenedioic acid; 1,2-Ethylenedicarboxylic Acid; Allomaleic Acid; trans-Butanedioic Acid; (E)-2-Butenedioic acid; trans-1,2-Ethylenedicarboxylic acid; Allomaleic acid; Boletic acid; CAS NO. 110-17-8
FUMARIC ACID E297
DESCRIPTION:
Fumaric acid E297 is an organic compound with the formula HO2CCH=CHCO2H.
A white solid, fumaric acid occurs widely in nature.
Fumaric acid E297 has a fruit-like taste and has been used as a food additive.

CAS Number , 110-17-8
EC Number , 203-743-0


SYNONYMS OF FUMARIC ACID E297:
Fumaric acid,trans-1,2-Ethylenedicarboxylic acid,2-Butenedioic acid,trans-Butenedioic acid,Allomaleic acid,Boletic acid,Donitic acid,Lichenic acid


Its E number is E297.
The salts and esters are known as fumarates.
Fumarate can also refer to the C4H2O2−4 ion (in solution).
Fumaric acid E297 is the trans isomer of butenedioic acid, while maleic acid is the cis isomer.

Fumaric acid E297, the strongest organic food acid commonly used as a flavoring agent and pH control agent.
Fumaric acid E297 provides more sourness than other acidulants, e.g. citric acid (E330) and malic acid (E296) in food.
The European food additive number for it is E297.

Chemical formula C4H4O4 is a compound in the category of trans-butene dioic acid, unsaturated carboxylic acids with crystals in the form of small prisms with open formula HO2CCH = CHCO2H.
Fumaric acid E297 is also called ethylene dicarboxylic acid.

Fumaric acid coded E297, found in most vegetables and fruits and is a natural acid.
Fumaric acid E297 is usually found in fungi and liver.

Fumaric acid E297 is the (cis-) isomer of matureic acid.
White odorless granule or crystalline powder.
Less soluble in water and ether, soluble in alcohol and very little soluble in chloroform.




PRODUCTION AND REACTIONS OF FUMARIC ACID E297:
Commercial production is carried out by sugar fermentation and chemical synthesis.
Feomidium can be produced by side reactions under appropriate temperature and conditions.
Salts and esters are known as fumarates.
As a result of hydration of formic acid, conversion to malic acid is observed.


BIOSYNTHESIS AND OCCURRENCE OF FUMARIC ACID E297:
It is produced in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase.
Fumaric acid is found in fumitory (Fumaria officinalis), bolete mushrooms (specifically Boletus fomentarius var. pseudo-igniarius), lichen, and Iceland moss.

Fumarate is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food.
Fumaric acid E297 is formed by the oxidation of succinate by the enzyme succinate dehydrogenase.

Fumarate is then converted by the enzyme fumarase to malate.
Human skin naturally produces fumaric acid when exposed to sunlight.
Fumarate is also a product of the urea cycle.



USES OF FUMARIC ACID E297:

Fumaric acid E297 is widely believed to effectively inhibit malolactic fermentation: existing bibliography describes it as being efficient in preventing its microbiological onset and in blocking it once it has already started.
All of these interesting aspects make it suitable for all vinification operations in which sulphur levels need to be contained.
For instance, it is ideal for making sparkling wine bases, but also for making fine white, rosé or red wines, for those seeking the pleasant taste that malic acidity offers.

When dosed as recommended, it causes a reduction in pH of approximately 1 to 2 tenths, depending on the wine’s buffer capacity, and increases total acidity compared to what would happen if tartaric acid were added.
However, according to current legislation, it is not classified as an acidifier, which means that it can be used even though it is not included in the relevant register.

The effect of Fumaric acid E297 persists for as long as the molecule is present in the medium: for example, it has been observed to last for many months when added to wine once the fermentation process is complete, during refinement without Saccharomyces cerevisiae activity.
Before using Fumaric acid E297, orientation tests should be carried out in the laboratory in order to be able to predict its effects on the sensory balance of the wine.
Fumaric acid E297 is the perfect complement in wine production lines for making wines without added sulphur dioxide

Food:
Fumaric acid has been used as a food acidulant since 1946.
Fumaric acid E297 is approved for use as a food additive in the EU,[6] USA[7] and Australia and New Zealand.
As a food additive, it is used as an acidity regulator and can be denoted by the E number E297.

Fumaric acid E297 is generally used in beverages and baking powders for which requirements are placed on purity.
Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening.
Fumaric acid E297 is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1 g of fumaric acid to every ~1.5 g of citric acid, in order to add sourness, similarly to the way malic acid is used.

As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips,[10] it is also used as a coagulant in stove-top pudding mixes.
The European Commission Scientific Committee on Animal Nutrition, part of DG Health, found in 2014 that fumaric acid is "practically non-toxic" but high doses are probably nephrotoxic after long-term use.


Fumaric acid is used in powder food production because it has low moisture retention in this sector.
It can be used as acidity regulator without changing the taste of foods.
Fruit juices, gelatinous desserts, chilled biscuit systems, wines, green foods, and sodium benzoate are used as preservatives, while fumaric acid is preferred to regulate acidity.

In rye and sour dough breads, the aroma density can be adjusted with fumaric acid in the dry mixture stage.
Fumaric acid E297 is used to improve pore structure in muffin type foods.
Fumaric acid E297 is used to extend the life of the confectionery because the moisture absorption rate is very low.

Fumaric acid E297 is Also used as anti-caking.
Fumaric acid E297 is used in paint and fast-drying inks.

Health:
It was observed that dimethyl fumarate decreased the progression of disability in multiplsclerosis after certain stages.

Medicine:
Fumaric acid was developed as a medicine to treat the autoimmune condition psoriasis in the 1950s in Germany as a tablet containing 3 esters, primarily dimethyl fumarate, and marketed as Fumaderm by Biogen Idec in Europe.
Biogen would later go on to develop the main ester, dimethyl fumarate, as a treatment for multiple sclerosis.

In patients with relapsing-remitting multiple sclerosis, the ester dimethyl fumarate (BG-12, Biogen) significantly reduced relapse and disability progression in a phase 3 trial.
Fumaric acid E297 activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic effects of oxidative stress.
Other uses:
Fumaric acid is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes.
When fumaric acid is added to their feed, lambs produce up to 70% less methane during digestion.[13]


SYNTHESIS OF FUMARIC ACID E297:
Fumaric acid is produced based on catalytic isomerisation of maleic acid in aqueous solutions at low pH.
Fumaric acid E297 precipitates from the reaction solution.
Maleic acid is accessible in large volumes as a hydrolysis product of maleic anhydride, produced by catalytic oxidation of benzene or butane.


HISTORIC AND LABORATORY ROUTES OF FUMARIC ACID E297:
Fumaric acid was first prepared from succinic acid.
A traditional synthesis involves oxidation of furfural (from the processing of maize) using chlorate in the presence of a vanadium-based catalyst.

REACTIONS OF FUMARIC ACID E297:
The chemical properties of fumaric acid can be anticipated from its component functional groups.
This weak acid forms a diester, it undergoes bromination across the double bond,[16] and it is a good dienophile.


PROPERTIES OF FUMARIC ACID E297:
Appearance:
Fumaric acid E297 is a white or nearly white crystalline powder or granular with a clean, persistent sourness with dryness.
The sourness is around 1.5 times that of citric acid.

PKa:
Fumaric acid is a weak organic acid containing two carboxylic acid functional groups and as a result it has two PKa values, PKa1 = 3.03 and PKa2 = 4.44.
Its PKa1 and PKa2 value is higher than that of citrate acid and malic acid.

PH :
Fumaric acid is an unsaturated di-carbonic acid and it has 2 dissociation equilibrium equations.
Its PH value is 2.03 in the concentration of 100 mM (0.1mol/L).

Calculation of the PH Value:
The method to calculate its PH is the same way with that of malic acid.
Fumaric acid E297 is a relatively strong acid and has a strong buffering property to maintain the pH of the aqueous solution at around 3.0, which is important for preservatives that function around pH 3.0.
Fumaric acid helps stabilize the pH of a fruit juice drink, which in turn makes colour and flavour stable.
Therefore, it is often used together with preservatives, such as sodium benzoate (E211).


Solubility:
In water:
Fumaric acid E297 has a solubility of 0.5% (0.5g/100ml) at 20°C in water while citric, malic and tartaric acid are all very soluble in water.
The hydrophobic of fumaric acid makes it an effective antimicrobial agent because it can disrupt microbial activity by interacting with lipid materials on the microbial cell wall.

In organic solvents:
Soluble in alcohol, slightly soluble in oils. Slightly soluble in acetone with solubility 1.29g/100g at 20°C. (7)


BENEFITS OF FUMARIC ACID E297:
Treatment of Psoriasis:
Due to its poor absorption after oral intake, fumaric acid esters, such as monoethyl fumarate (MEF) and dimethyl fumarate (DMF) are used for the treatment of psoriasis.
However, several side effects occurred in the studies from the year 1990-1998. Including (8):
• Flushing
• Diarrhoea
• Kidney retention
• A reversible elevation of transaminases, lymphocytopenia and eosinophilia.
• Gastrointestinal complaints, mild stomach upsets, increased frequency of defecation and tenesmus, to stomach cramps, tympanites and diarrhoea.


USES OF FUMARIC ACID E297:
Fumaric acid is the strongest organic food acid.
Fumaric acid E297 is used as a flavoring agent for its sourness taste, and an antimicrobial agent for its hydrophobic characteristic.
Generally, it is used in food, beverage, animal nutrition, cosmetics, and pharmaceutical industry.


Food:
When compared to other acidulants like citric acid, fumaric acid can be used in dry mix products as it is non-hygroscopic and will not absorb moisture.
This advantage makes dry mix products do not cake or harden during storage.
In beverage, fumaric acid functions as a PH control agent and enhancing flavor.


Besides this beverage application, we can also find the following food products containing it and its other functions (9):
Bakery and tortillas: as a leavening acid in the leavening agent and also acts as a flavoring agent for savory baked goods.
Confectionaries and desserts: non-hygroscopic agent.
Chewing gum: slow dissolution and hydrophobicity property, prolongs the sourness in the mouth so that it enhances the flavor of chewing gum.


Cosmetics:
Per the “European Commission database for information on cosmetic substances and ingredients”, it acts as a buffering in cosmetic and personal care products.



CHEMICAL AND PHYSICAL PROPERTIES OF FUMARIC ACID E297

Chemical formula, C4H4O4
Molar mass, 116.072 g•mol−1
Appearance, White solid
Density, 1.635 g/cm3
Melting point, 287 °C (549 °F; 560 K) (decomposes)[2]
Solubility in water, 4.9 g/L at 20 °C[1]
Acidity (pKa), pka1 = 3.03, pka2 = 4.44 (15 °C, cis isomer)
Magnetic susceptibility (χ), −49.11•10−6 cm3/mol
Dipole moment, non zero
Other Names, Boletic acidAllomaleic acidTrans-butenedioic acidTrans-1,2-Ethylenedicarboxylic acid
CAS Number, 110-17-8
Chemical formula, C4H4O4
Molecular Weight, 116.072
Melting Point, 287 °C
Boiling Point, 156 °C
CAS number: 110-17-8
ChemSpider: 10197150
UNII: 88XHZ13131
EC Number: 203-743-0
DrugBank: DB04299
KEGG: C00122
Chebi: 18012
CHEMBL503160
ATC code: D05AX01
Molecular formula: C4H4O4
Molar mass: 116.07 g / mol
Appearance: White solid
Density: 1.635 g / cm3, solid
Melting point: 287 ° C
Solubility in water: 0.63 g / 100 mL
Acid (pKa): pka1 = 3.03, pka2 = 4.44
EU classification: Irritant (Xi)
R-phrases: R36
S-phrases: (S2) S26
Other names: Trans-butenedioic acid
APPEARANCE, WHITE CRYSTAL POWDER
CONTENT, 99.5 %-100.5%
MELTING POINT, 294-300
ARSENIC mg/kg, ≤3
HEAVEY METAL(AS Pb), ≤10ppm
MALEIC ACID %, ≤0.10%
RESIDUE ON IGNTION, ≤0.10%
MOISTURE, ≤0.5%
Melting point , 298-300 °C (subl.)(lit.)
Boiling point , 137.07°C (rough estimate)
density , 1.62
vapor pressure , 1.7 mm Hg ( 165 °C)
FEMA , 2488 | FUMARIC ACID
refractive index , 1.5260 (estimate)
Fp , 230 °C
storage temp. , Store below +30°C.
solubility , 95% ethanol: soluble0.46g/10 mL, clear, colorless
form , Fine Crystalline Powder
pka, 3.02, 4.38(at 25ºC)
color , White
PH, 2.1 (4.9g/l, H2O, 20ºC)
explosive limit, 40%
Water Solubility , 0.63 g/100 mL (25 ºC)
JECFA Number, 618
Merck , 14,4287
BRN , 605763
Stability:, Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
InChIKey, VZCYOOQTPOCHFL-OWOJBTEDSA-N
CAS DataBase Reference, 110-17-8(CAS DataBase Reference)
NIST Chemistry Reference, Fumaric acid(110-17-8)
EPA Substance Registry System, Fumaric acid (110-17-8)



QUESTIONS AND ANSWERS ABOUT FUMARIC ACID E297
WHAT IS FUMARIC ACID?:
Fumaric acid E297 is a weak organic acid (a dicarboxylic acid) commercially made from maleic acid and with chemical formula C4H4O4.
Fumaric acid E297 is a precursor for the production of other acids, like L-aspartic acid and L-malic acid.
Fumarate, citrate and malate are all the intermediate in the tricarboxylic acid cycle or KREBS cycle to produce energy in the form of ATP in our humans and most living cells.


What are the Natural Sources?
Fumaric acid E297 can be naturally found in fumitory, bolete mushrooms, lichen, and Iceland moss.
Also, Fumaric acid E297 presents in fruits such as apple and watermelon.
Generally, it is less found in most fruits than another two acidulants, citric acid and malic acid.


How is it Made?:
Fumaric acid can be produced by the isomerization of maleic acid or glucose fermentation.
The following are the two manufacturing processes:

1. Isomerization of Maleic Acid:
Commonly the production is chemically synthesized from isomerization of maleic acid which is the hydrolysis of maleic anhydride.
Maleic anhydride is the cis-counterpart of fumaric acid.
Fumaric acid E297 is manufactured from butane, butene, or benzene from petroleum are the starting materials.

2. Sugar fermentation:
Fermentation by Rhizopus species using glucose or other carbohydrate substrates.
SAFETY INFORMATION ABOUT FUMARIC ACID E297 :
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product


FUMARIC ACID FOOD GRADE
DESCRIPTION:
Fumaric acid food grade is an organic compound with the formula HO2CCH=CHCO2H.
A white solid, fumaric acid occurs widely in nature.
Fumaric acid food grade has a fruit-like taste and has been used as a food additive.

CAS Number , 110-17-8
EC Number , 203-743-0


SYNONYMS OF FUMARIC ACID FOOD GRADE:
Fumaric acid,trans-1,2-Ethylenedicarboxylic acid,2-Butenedioic acid,trans-Butenedioic acid,Allomaleic acid,Boletic acid,Donitic acid,Lichenic acid


Its E number is E297.
The salts and esters are known as fumarates.
Fumarate can also refer to the C4H2O2−4 ion (in solution).
Fumaric acid food grade is the trans isomer of butenedioic acid, while maleic acid is the cis isomer.

Fumaric acid food grade, the strongest organic food acid commonly used as a flavoring agent and pH control agent.
Fumaric acid food grade provides more sourness than other acidulants, e.g. citric acid (E330) and malic acid (E296) in food.
The European food additive number for it is E297.

Chemical formula C4H4O4 is a compound in the category of trans-butene dioic acid, unsaturated carboxylic acids with crystals in the form of small prisms with open formula HO2CCH = CHCO2H.
Fumaric acid food grade is also called ethylene dicarboxylic acid.

Fumaric acid coded E297, found in most vegetables and fruits and is a natural acid.
Fumaric acid food grade is usually found in fungi and liver.

Fumaric acid food grade is the (cis-) isomer of matureic acid.
White odorless granule or crystalline powder.
Less soluble in water and ether, soluble in alcohol and very little soluble in chloroform.




PRODUCTION AND REACTIONS OF FUMARIC ACID FOOD GRADE:
Commercial production is carried out by sugar fermentation and chemical synthesis.
Feomidium can be produced by side reactions under appropriate temperature and conditions.
Salts and esters are known as fumarates.
As a result of hydration of formic acid, conversion to malic acid is observed.


BIOSYNTHESIS AND OCCURRENCE OF FUMARIC ACID FOOD GRADE:
It is produced in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase.
Fumaric acid is found in fumitory (Fumaria officinalis), bolete mushrooms (specifically Boletus fomentarius var. pseudo-igniarius), lichen, and Iceland moss.

Fumarate is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food.
Fumaric acid food grade is formed by the oxidation of succinate by the enzyme succinate dehydrogenase.

Fumarate is then converted by the enzyme fumarase to malate.
Human skin naturally produces fumaric acid when exposed to sunlight.
Fumarate is also a product of the urea cycle.



USES OF FUMARIC ACID FOOD GRADE:

Fumaric acid food grade is widely believed to effectively inhibit malolactic fermentation: existing bibliography describes it as being efficient in preventing its microbiological onset and in blocking it once it has already started.
All of these interesting aspects make it suitable for all vinification operations in which sulphur levels need to be contained.
For instance, it is ideal for making sparkling wine bases, but also for making fine white, rosé or red wines, for those seeking the pleasant taste that malic acidity offers.

When dosed as recommended, it causes a reduction in pH of approximately 1 to 2 tenths, depending on the wine’s buffer capacity, and increases total acidity compared to what would happen if tartaric acid were added.
However, according to current legislation, it is not classified as an acidifier, which means that it can be used even though it is not included in the relevant register.

The effect of Fumaric acid food grade persists for as long as the molecule is present in the medium: for example, it has been observed to last for many months when added to wine once the fermentation process is complete, during refinement without Saccharomyces cerevisiae activity.
Before using Fumaric acid food grade, orientation tests should be carried out in the laboratory in order to be able to predict its effects on the sensory balance of the wine.
Fumaric acid food grade is the perfect complement in wine production lines for making wines without added sulphur dioxide

Food:
Fumaric acid has been used as a food acidulant since 1946.
Fumaric acid food grade is approved for use as a food additive in the EU,[6] USA[7] and Australia and New Zealand.
As a food additive, it is used as an acidity regulator and can be denoted by the E number E297.

Fumaric acid food grade is generally used in beverages and baking powders for which requirements are placed on purity.
Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening.
Fumaric acid food grade is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1 g of fumaric acid to every ~1.5 g of citric acid, in order to add sourness, similarly to the way malic acid is used.

As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips,[10] it is also used as a coagulant in stove-top pudding mixes.
The European Commission Scientific Committee on Animal Nutrition, part of DG Health, found in 2014 that fumaric acid is "practically non-toxic" but high doses are probably nephrotoxic after long-term use.


Fumaric acid is used in powder food production because it has low moisture retention in this sector.
It can be used as acidity regulator without changing the taste of foods.
Fruit juices, gelatinous desserts, chilled biscuit systems, wines, green foods, and sodium benzoate are used as preservatives, while fumaric acid is preferred to regulate acidity.

In rye and sour dough breads, the aroma density can be adjusted with fumaric acid in the dry mixture stage.
Fumaric acid food grade is used to improve pore structure in muffin type foods.
Fumaric acid food grade is used to extend the life of the confectionery because the moisture absorption rate is very low.

Fumaric acid food grade is Also used as anti-caking.
Fumaric acid food grade is used in paint and fast-drying inks.

Health:
It was observed that dimethyl fumarate decreased the progression of disability in multiplsclerosis after certain stages.

Medicine:
Fumaric acid was developed as a medicine to treat the autoimmune condition psoriasis in the 1950s in Germany as a tablet containing 3 esters, primarily dimethyl fumarate, and marketed as Fumaderm by Biogen Idec in Europe.
Biogen would later go on to develop the main ester, dimethyl fumarate, as a treatment for multiple sclerosis.

In patients with relapsing-remitting multiple sclerosis, the ester dimethyl fumarate (BG-12, Biogen) significantly reduced relapse and disability progression in a phase 3 trial.
Fumaric acid food grade activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic effects of oxidative stress.
Other uses:
Fumaric acid is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes.
When fumaric acid is added to their feed, lambs produce up to 70% less methane during digestion.[13]


SYNTHESIS OF FUMARIC ACID FOOD GRADE:
Fumaric acid is produced based on catalytic isomerisation of maleic acid in aqueous solutions at low pH.
Fumaric acid food grade precipitates from the reaction solution.
Maleic acid is accessible in large volumes as a hydrolysis product of maleic anhydride, produced by catalytic oxidation of benzene or butane.


HISTORIC AND LABORATORY ROUTES OF FUMARIC ACID FOOD GRADE:
Fumaric acid was first prepared from succinic acid.
A traditional synthesis involves oxidation of furfural (from the processing of maize) using chlorate in the presence of a vanadium-based catalyst.

REACTIONS OF FUMARIC ACID FOOD GRADE:
The chemical properties of fumaric acid can be anticipated from its component functional groups.
This weak acid forms a diester, it undergoes bromination across the double bond,[16] and it is a good dienophile.


PROPERTIES OF FUMARIC ACID FOOD GRADE:
Appearance:
Fumaric acid food grade is a white or nearly white crystalline powder or granular with a clean, persistent sourness with dryness.
The sourness is around 1.5 times that of citric acid.

PKa:
Fumaric acid is a weak organic acid containing two carboxylic acid functional groups and as a result it has two PKa values, PKa1 = 3.03 and PKa2 = 4.44.
Its PKa1 and PKa2 value is higher than that of citrate acid and malic acid.

PH :
Fumaric acid is an unsaturated di-carbonic acid and it has 2 dissociation equilibrium equations.
Its PH value is 2.03 in the concentration of 100 mM (0.1mol/L).

Calculation of the PH Value:
The method to calculate its PH is the same way with that of malic acid.
Fumaric acid food grade is a relatively strong acid and has a strong buffering property to maintain the pH of the aqueous solution at around 3.0, which is important for preservatives that function around pH 3.0.
Fumaric acid helps stabilize the pH of a fruit juice drink, which in turn makes colour and flavour stable.
Therefore, it is often used together with preservatives, such as sodium benzoate (E211).


Solubility:
In water:
Fumaric acid food grade has a solubility of 0.5% (0.5g/100ml) at 20°C in water while citric, malic and tartaric acid are all very soluble in water.
The hydrophobic of fumaric acid makes it an effective antimicrobial agent because it can disrupt microbial activity by interacting with lipid materials on the microbial cell wall.

In organic solvents:
Soluble in alcohol, slightly soluble in oils. Slightly soluble in acetone with solubility 1.29g/100g at 20°C. (7)


BENEFITS OF FUMARIC ACID FOOD GRADE:
Treatment of Psoriasis:
Due to its poor absorption after oral intake, fumaric acid esters, such as monoethyl fumarate (MEF) and dimethyl fumarate (DMF) are used for the treatment of psoriasis.
However, several side effects occurred in the studies from the year 1990-1998. Including (8):
• Flushing
• Diarrhoea
• Kidney retention
• A reversible elevation of transaminases, lymphocytopenia and eosinophilia.
• Gastrointestinal complaints, mild stomach upsets, increased frequency of defecation and tenesmus, to stomach cramps, tympanites and diarrhoea.


USES OF FUMARIC ACID FOOD GRADE:
Fumaric acid is the strongest organic food acid.
Fumaric acid food grade is used as a flavoring agent for its sourness taste, and an antimicrobial agent for its hydrophobic characteristic.
Generally, it is used in food, beverage, animal nutrition, cosmetics, and pharmaceutical industry.


Food:
When compared to other acidulants like citric acid, fumaric acid can be used in dry mix products as it is non-hygroscopic and will not absorb moisture.
This advantage makes dry mix products do not cake or harden during storage.
In beverage, fumaric acid functions as a PH control agent and enhancing flavor.


Besides this beverage application, we can also find the following food products containing it and its other functions (9):
Bakery and tortillas: as a leavening acid in the leavening agent and also acts as a flavoring agent for savory baked goods.
Confectionaries and desserts: non-hygroscopic agent.
Chewing gum: slow dissolution and hydrophobicity property, prolongs the sourness in the mouth so that it enhances the flavor of chewing gum.


Cosmetics:
Per the “European Commission database for information on cosmetic substances and ingredients”, it acts as a buffering in cosmetic and personal care products.



CHEMICAL AND PHYSICAL PROPERTIES OF FUMARIC ACID FOOD GRADE

Chemical formula, C4H4O4
Molar mass, 116.072 g•mol−1
Appearance, White solid
Density, 1.635 g/cm3
Melting point, 287 °C (549 °F; 560 K) (decomposes)[2]
Solubility in water, 4.9 g/L at 20 °C[1]
Acidity (pKa), pka1 = 3.03, pka2 = 4.44 (15 °C, cis isomer)
Magnetic susceptibility (χ), −49.11•10−6 cm3/mol
Dipole moment, non zero
Other Names, Boletic acidAllomaleic acidTrans-butenedioic acidTrans-1,2-Ethylenedicarboxylic acid
CAS Number, 110-17-8
Chemical formula, C4H4O4
Molecular Weight, 116.072
Melting Point, 287 °C
Boiling Point, 156 °C
CAS number: 110-17-8
ChemSpider: 10197150
UNII: 88XHZ13131
EC Number: 203-743-0
DrugBank: DB04299
KEGG: C00122
Chebi: 18012
CHEMBL503160
ATC code: D05AX01
Molecular formula: C4H4O4
Molar mass: 116.07 g / mol
Appearance: White solid
Density: 1.635 g / cm3, solid
Melting point: 287 ° C
Solubility in water: 0.63 g / 100 mL
Acid (pKa): pka1 = 3.03, pka2 = 4.44
EU classification: Irritant (Xi)
R-phrases: R36
S-phrases: (S2) S26
Other names: Trans-butenedioic acid
APPEARANCE, WHITE CRYSTAL POWDER
CONTENT, 99.5 %-100.5%
MELTING POINT, 294-300
ARSENIC mg/kg, ≤3
HEAVEY METAL(AS Pb), ≤10ppm
MALEIC ACID %, ≤0.10%
RESIDUE ON IGNTION, ≤0.10%
MOISTURE, ≤0.5%
Melting point , 298-300 °C (subl.)(lit.)
Boiling point , 137.07°C (rough estimate)
density , 1.62
vapor pressure , 1.7 mm Hg ( 165 °C)
FEMA , 2488 | FUMARIC ACID
refractive index , 1.5260 (estimate)
Fp , 230 °C
storage temp. , Store below +30°C.
solubility , 95% ethanol: soluble0.46g/10 mL, clear, colorless
form , Fine Crystalline Powder
pka, 3.02, 4.38(at 25ºC)
color , White
PH, 2.1 (4.9g/l, H2O, 20ºC)
explosive limit, 40%
Water Solubility , 0.63 g/100 mL (25 ºC)
JECFA Number, 618
Merck , 14,4287
BRN , 605763
Stability:, Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
InChIKey, VZCYOOQTPOCHFL-OWOJBTEDSA-N
CAS DataBase Reference, 110-17-8(CAS DataBase Reference)
NIST Chemistry Reference, Fumaric acid(110-17-8)
EPA Substance Registry System, Fumaric acid (110-17-8)



QUESTIONS AND ANSWERS ABOUT FUMARIC ACID FOOD GRADE
WHAT IS FUMARIC ACID?:
Fumaric acid food grade is a weak organic acid (a dicarboxylic acid) commercially made from maleic acid and with chemical formula C4H4O4.
Fumaric acid food grade is a precursor for the production of other acids, like L-aspartic acid and L-malic acid.
Fumarate, citrate and malate are all the intermediate in the tricarboxylic acid cycle or KREBS cycle to produce energy in the form of ATP in our humans and most living cells.


What are the Natural Sources?
Fumaric acid food grade can be naturally found in fumitory, bolete mushrooms, lichen, and Iceland moss.
Also, Fumaric acid food grade presents in fruits such as apple and watermelon.
Generally, it is less found in most fruits than another two acidulants, citric acid and malic acid.


How is it Made?:
Fumaric acid can be produced by the isomerization of maleic acid or glucose fermentation.
The following are the two manufacturing processes:

1. Isomerization of Maleic Acid:
Commonly the production is chemically synthesized from isomerization of maleic acid which is the hydrolysis of maleic anhydride.
Maleic anhydride is the cis-counterpart of fumaric acid.
Fumaric acid food grade is manufactured from butane, butene, or benzene from petroleum are the starting materials.

2. Sugar fermentation:
Fermentation by Rhizopus species using glucose or other carbohydrate substrates.
SAFETY INFORMATION ABOUT FUMARIC ACID FOOD GRADE :
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
FUMED SILICA
Fumed silica is a silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Fumed silica may be synthesized by high temperature hydrolysis of SiCl4 in O2(N2)/H2 flame.
Fumed silica is amorphous in nature and possesses very high specific area.

CAS: 112945-52-5
MF: O2Si
MW: 60.08
EINECS: 231-545-4

The micro droplets of amorphous Fumed silica fuse into a branch and form a chain like agglomerate.
Fumed silica, also known as pyrogenic silica because it is produced in a flame, consists of microscopic droplets of amorphous silica fused into branched, chainlike, three-dimensional secondary particles which then agglomerate into tertiary particles.
The resulting powder has an extremely low bulk density and high surface area.
Fumed silica's three-dimensional structure results in viscosity-increasing, thixotropic behavior when used as a thickener or reinforcing filler.

Fumed silica Chemical Properties
Melting point: >1600°C
Density: 2.3 lb/cu.ft at 25 °C (bulk density)(lit.)
Refractive index: n20/D 1.46(lit.)
Solubility: Practically insoluble in organic solvents, water, and acids, except hydrofluoric acid; soluble in hot solutions of alkali hydroxide.
Forms a colloidal dispersion with water.
For Aerosil, solubility in water is 150 mg/L at 258℃ (pH 7).
Form: powder
Specific Gravity: 2.2
Hydrolytic Sensitivity 5: forms reversible hydrate
CAS DataBase Reference: 112945-52-5(CAS DataBase Reference)
EPA Substance Registry System: Fumed silica (112945-52-5)

Fumed silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder.
Fumed silica is a submicroscopic fumed silica with a particle size of about 15 nm.
Fumed silica is a light, loose, bluish-white-colored, odorless, tasteless, amorphous powder.
Fumed silica has a very strong thickening effect.
Primary particle size is 5–50 nm.
The particles are non-porous and have a surface area of 50–600 m2/g.
The density is 160–190 kg/m3.

Uses
Fumed silica has interesting thickening and thixotropic properties, and an enormous external surface area.
Fumed silica is produced by a vapor phase hydrolysis process using chlorosilanes or substituted silanes such as, silicon tetrachloride in a flame of hydrogen and oxygen.
Fumed silica is formed and collected in a dry state.
Fumed silica contains no detectable crystalline silica.

Fumed silica serves as a universal thickening agent and an anticaking agent (free-flow agent) in powders. Like silica gel, it serves as a desiccant.
Fumed silica is used in cosmetics for its light-diffusing properties.
Fumed silica is used as a light abrasive, in products like toothpaste. Other uses include filler in silicone elastomer and viscosity adjustment in paints, coatings, printing inks, adhesives and unsaturated polyester resins.
Fumed silica readily forms a network structure within bitumen and enhances its elasticity.

Pharmaceutical Applications
Fumed silica is widely used in pharmaceuticals, cosmetics, and food products.
Fumed silica's small particle size and large specific surface area give it desirable flow characteristics that are exploited to improve the flow properties of dry powders in a number of processes such as tableting and capsule filling.
Fumed silica is also used to stabilize emulsions and as a thixotropic thickening and suspending agent in gels and semisolid preparations.
With other ingredients of similar refractive index, transparent gels may be formed.

The degree of viscosity increase depends on the polarity of the liquid (polar liquids generally require a greater concentration of colloidal silicon dioxide than nonpolar liquids).
Viscosity is largely independent of temperature.
However, changes to the pH of a system may affect the viscosity1.
In aerosols, other than those for inhalation, Fumed silica is used to promote particulate suspension, eliminate hard settling, and minimize the clogging of spray nozzles.
Fumed silica is also used as a tablet disintegrant and as an adsorbent dispersing agent for liquids in powders.

Fumed silica is frequently added to suppository formulations containing lipophilic excipients to increase viscosity, prevent sedimentation during molding, and decrease the release rate.
Fumed silica is also used as an adsorbent during the preparation of wax microspheres; as a thickening agent for topical preparations; and has been used to aid the freeze-drying of nanocapsules and nanosphere suspensions.

Production
Fumed silica is made from flame pyrolysis of silicon tetrachloride or from quartz sand vaporized in a 3000 °C electric arc.
Fumed silica is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 18008℃ using a hydrogen–oxygen flame.
Rapid cooling from the molten state during manufacture causes the product to remain amorphous.
Purification of Fumed silica for high technology applications uses isopiestic vapour distillation from concentrated volatile acids and is absorbed in high purity water.
The impurities remain behind.
Preliminary cleaning to remove surface contaminants uses dip etching in HF or a mixture of HCl, H2O2 and deionised water.

Synonyms
SILICON DIOXIDE
Silica
Quartz
Dioxosilane
7631-86-9
Cristobalite
14808-60-7
Silicic anhydride
Tridymite
Sand
112945-52-5
61790-53-2
KIESELGUHR
Aerosil
112926-00-8
Silicon(IV) oxide
Wessalon
Diatomaceous silica
Zorbax sil
Crystalline silica
Silica, amorphous
60676-86-0
Dicalite
Glass
Ludox
Nyacol
14464-46-1
Amorphous silica
QUARTZ (SIO2)
Cab-O-sil
Christensenite
Crystoballite
Sillikolloid
Extrusil
Santocel
Sipernat
Superfloss
Acticel
Carplex
Celite
Neosil
Neosyl
Porasil
Silikil
Siloxid
Zipax
Aerosil-degussa
Silicon oxide
Aerosil 380
Synthetic amorphous silica
White carbon
Quartz sand
Silica particles
Cab-o-sil M-5
Cristobalite (SiO2)
Silica, fumed
Vulkasil S
Snowtex O
Corasil II
Silica, colloidal
Tokusil TPLM
Dri-Die
SILICA, VITREOUS
91053-39-3
Cabosil st-1
Manosil vn 3
Colloidal silicon dioxide
Ultrasil VH 3
Ultrasil VN 3
Aerosil bs-50
Carplex 30
Carplex 80
Snowtex 30
Zeofree 80
Aerosil K 7
Cabosil N 5
Syton 2X
Amorphous silica gel
Positive sol 232
Siliziumdioxid
Aerogel 200
Aerosil 300
Chalcedony
Diatomite
Ludox hs 40
Silanox 101
Silica (SiO2)
Vitasil 220
Agate
Positive sol 130M
Silica vitreous
Silicon dioxide (amorphous)
Aerosil A 300
Aerosil E 300
Aerosil M-300
colloidal silica
Fused silica
Quartz glass
Silica slurry
Silicon dioxide, fumed
FUMED SILICA
DESCRIPTION:
Fumed silica (CAS number 112945-52-5), also known as pyrogenic silica because Fumed silica is produced in a flame, consists of microscopic droplets of amorphous silica fused into branched, chainlike, three-dimensional secondary particles which then agglomerate into tertiary particles.
The resulting powder has an extremely low bulk density and high surface area.
Its three-dimensional structure results in viscosity-increasing, thixotropic behavior when used as a thickener or reinforcing filler.

CAS: 65997-17-3
EC No.: 262-373-8
MDL Number: MFCD00011232
Linear Formula: SiO2
Chemical Name: Synthetic Amorphous Silicon Dioxide, Crystalline- free

CHEMICAL AND PHYSICAL PROPERTIES OF FUMED SILICA:
Molecular Weight: 60.08
Appearance: White Powder
Melting Point: 1,600° C
Boiling Point: 2,230° C
Density: ~2.3-4.5 g/cm3
Size Range: 7-1.4 nm
Specific Surface Area: 200-390 m2/g
Morphology: Spherical

Fumed silica is an ultra-fine powder additive that can be added to resin and gelcoats to make them more thixotropic.
Also known as colloidal silica, fumed silica can be used to transform epoxy or polyester resin into a thick gelcoat or, with the addition of glass bubbles, into a lightweight filler.

Fumed silica has a very strong thickening effect.
Primary particle size is 5–50 nm.
The particles are non-porous and have a surface area of 50–600 m2/g.

The density is 160–190 kg/m3.
Fumed silica may be synthesized by high temperature hydrolysis of SiCl4 in O2(N2)/H2 flame.
Fumed silica is amorphous in nature and possesses very high specific area.
The micro droplets of amorphous silica fuse into a branch and form a chain like agglomerate.

Fumed Silica is a powder composed of submicron-sized amorphous silica spheres arranged in branching chains of varying lengths.
To produce fumed silica, silicon tetrachloride or quartz is burnded in a flame of hydrogen and oxygen to yield molten uniform-sized spheres that subsequently fuse into three-dimensional aggregates.
Though the lengths and shapes of these chains differ (lending it an enormous external surface area), the size of the spheres themselves can be controlled during the preparation process.

Fumed silica exhibits thixotropic properties and is typically used as a dessicant, thickening and anti-caking agent, and stabilizer in pharmaceuticals, cosmetics, paints and coatings, sealants, and gel-cell batteries (as an additive to acid-based electrolytes).
American Elements can produce both hydrophilic and hydrophobic (treated) fumed silica in a range of different sizes and surface areas.

Fumed silica is an extremely small particle with enormous surface area, high purity, and a tendency to form chains in the chemical manufacturing process.
Particles are formed by injecting chlorosilanes, such as silicon tetrachloride, into a flame of hydrogen and air.
The ensuring reaction produces fumed silica and hydrogen chloride.

PRODUCTION OF FUMED SILICA:
Fumed silica is made from flame pyrolysis of silicon tetrachloride or from quartz sand vaporized in a 3000 °C electric arc.
Major global producers are Evonik (who sells it under the name Aerosil), Cabot Corporation (Cab-O-Sil), Wacker Chemie (HDK), Dow Corning, Heraeus (Zandosil), Tokuyama Corporation (Reolosil), OCI (Konasil), Orisil (Orisil) and Xunyuchem.

USAGE OF FUMED SILICA:
Fumed silica is a basic functional product used in construction, automobile, semiconductors, etc.
Fumed silica acts as a function reinforcement agent, and it can also optimize a product by improving anti-sagging and anti-settling effects or abrasive properties.
The fumed silica business continues to advance alongside the growth of mobile phone, kitchenware, cosmetics, construction, automobile, semiconductors, shipbuilding, etc.


APPLICATIONS OF FUMED SILICA:
Fumed silica serves as a universal thickening agent and an anticaking agent (free-flow agent) in powders.
Like silica gel, Fumed silica serves as a desiccant.
Fumed silica is used in cosmetics for its light-diffusing properties.
Fumed silica is used as a light abrasive, in products like toothpaste.
Other uses include filler in silicone elastomer and viscosity adjustment in paints, coatings, printing inks, adhesives and unsaturated polyester resins.

Fumed silica is used to deplete lipids and hormones in Taqman assays of human hepatoma cells HuH-7 and human liver cell line HepG2.
Preparation of epoxidized natural rubber/fumed silica composites have been reported.

Interaction of Gemini surfactant C12-s-C122Br with aqueous suspension of fumed silica has been studied.
Fumed silica based nanocomposites reinforced with organo clay may be prepared.
TiO2/fumed silica porous ceramic material was used to prepare photocatalytic materials.

Fumed silica is used in laminating and gelcoat applications, and provides proper rheological control, while achieving optimum shear thinning and enhancing the end-use application.

Fumed silica has two primary functions.
Reinforcement increases the strength of various materials, allowing them to be used in a wider number of applications in accordance with the user's exact requirements.
Rheology control allows customers to tailor the viscosity of a system to their own requirements.

Fumed silica serves as a universal thickening agent, a thickener in milkshakes, and a anticaking agent in powdered foods.
Like silica gel, Fumed silica serves as a desiccant.
Fumed silica is used in cosmetics for its light-diffusing properties.

Fumed silica is used as a light abrasive, in products like toothpaste.
Other uses include filler in silicone elastomer and viscosity adjustment in paints, coatings, printing inks, adhesives, cosmetics, sealants, toiletries, food, beverages and unsaturated polyester resins.
• Unsaturated polyester resins
• Silicone resins and urethane resins
• Semiconductor field (CMP slurry)
• Various types of paint
• Various types of inks
• Various types of adhesives
• Inkjet paper
• Shoe soles (clear rubber)
• Water-absorbing resin
• Toner
• Food additives


HOW TO USE FUMED SILICA:
Fumed Silica requires significant agitation (stirring) to become fully mixed into a resin.
Use of a mechanical stirrer will make the process quicker and easier but manual mixing is perfectly possible.
For maximum effect, allow the Fumed Silica to soak in the resin for as much as a day before thorough mixing.

Fumed Silica added to resin at a ratio of 0.7% - 1% (by weight) will produce a thixotropic resin.
2-3% will produce a gelcoat consistency.
Percentages up to 3%+ can be used to make a filler paste (additional filler powders may be required).

Please note the addition of Fumed Silica will reduce the clarity of clear resin systems meaning it is not ideal for turning clear laminating resin into a clear gelcoat.


TYPICAL APPLICATIONS OF FUMED SILICA:
• Rheology and thixotropy control in coatings, inks, sealants & adhesives
• Improving anti-corrosion properties of protective coatings
• Scratch resistance in coatings
• Thickening and hydrophobicity of greases
• Electrolyte immobilization in lead-acid batteries
• Anti-settling agent in pigment dispersions and suspension concentrates
• Solid carrier for liquids
• Mechanical and optical enhancement of silicone rubbers
• Impart free-flow and anti-caking properties in powders
• Metal and glass polishing

KEY PROPERTIES AND EFFECTS OF FUMED SILICA:
Thickening and thixotropy:
Fumed Silica provides thickening and thixotropic effects in liquid systems such as polyesters, epoxies, and urethane resins due to interaction between aggregates and the development of three-dimensional networks between Fumed Silica particles.

Reinforcement:
Adding Fumed Silica as a filler material improves various mechanical properties of elastomers, including modulus, elongation at break, tensile strength and tear resistance.
Fumed Silica’s large specific surface area also makes it possible to achieve excellent transparency in elastomers.

Anti-settling effects:
Fumed Silica improves the suspension behavior in liquid systems, such as pigmented coatings or resins containing fillers.

Anti-caking, effects for improved flow characteristics:
Due to a property that makes it behave like ball bearings, Fumed Silica resists lumping and clogging.
Fumed Silica can be used to improve the storage stability of powders that are especially prone to caking.
Fumed Silica can also be used to improve flow characteristics and prevent flow problems.

Anti-blocking effects:
Fumed Silica is added to film resins to reduce “sticking”.
Fumed Silica reduces close contact between film layers.

Adsorbent:
Gaseous, liquid or solid materials can be precipitated or adsorbed on the surface of Fumed Silica.
This serves as an ideal carrier or substrate for active ingredients due to its high specific surface area and inertness in the presence of all chemicals except strong alkalis and hydrofluoric acid.

Insulation:
With its very low solid state conductivity and vast spacing between particles, Fumed Silica provides excellent electrical and thermal insulation properties.

Electrical charge:
Hydrophobic Fumed Silica is used as a toner additive to stabilize electrical charge characteristics.

Polishing:
In the semiconductor manufacturing process, the planarization of silicon wafers is achieved via CMP (Chemical Mechanical Polishing) processes such as ILD, STI and metal CMP.
Fumed Silica is used in certain CMP slurries as a polishing agent, due to high purity, sub-micron particle size and its distribution characteristics.

Food applications :
Fumed Silica is fluffy white powder and is used in various food applications for flowability improving, anti-settling, liquid adsorption, liquid thickening, moisture adsorption, microencapsulation, flavor masking, for example.

FEATURES OF FUMED SILICA:
Fumed Silica is Chemically inert synthetic amorphous silica.
Fumed Silica has High purity.
Fumed Silica is Available in hydrophilic and surface-treated hydrophobic grades.

Fumed Silica has A wide range of surface areas available.
Fumed Silica has Broad legislative approvals on many grades e.g. indirect food contact.
Mixed fumed silica/metal oxide grades available.

BENEFITS OF FUMED SILICA:
Fumed Silica has Efficient rheology control in a wide range of simple and complex liquid systems.
Fumed Silica Imparts viscosity, pseudoplasticity and thixotropy.
Fumed Silica Stabilises pigments and prevents sagging.

Fumed Silica Provides effective free flow and anti-caking behaviour.
Fumed Silica Can be used as a solid carrier for liquids.
Fumed Silica Improves mechanical and optical properties of silicone rubber.

Fumed Silica Improves anti-corrosion performance of protective and marine coatings.
Fumed Silica Reduces moistures sensitivity and increases hydrophobicity.
Fumed Silica is Useful in silicone sealants for extending shelf life for example.

Fumed Silica is Anti-blocking agent for PET films.
Fumed Silica has Many more applications: greases, batteries, agrochemicals etc.

SAFETY INFORMATION ABOUT FUMED SILICA:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.


SYNONYMS OF FUMED SILICA:
pyrogenic silica
fumed silica
M-5
colloidal silica
synthetic silica
alpha-crystobalite
amethyst
amorphous fumed silica
amorphous silica
cristobalite (SiO2)
CAS# 65997-17-3
fossil flour
silicon dioxide (amorphous)
silicon dioxide- fumed
silicon(IV) oxide
synthetic amorphous silica- fumed
silikill
sillikolloid
siloxid
synthetic amorphous silica- fumed
tridimite
tridymite
vulkasil
vulkasil S
wessalon



Fumed Silica
Methanoic acid; Formylic acid; Hydrogencarboxylic acid; aminic acid; formylic acid; Formic acid; Acide Formique; Acido Formico; Ameisensaeure; Kwas Metaniowy; Kyselina Mravenci; Ameisensäure; Mierenzuur; ácido fórmico; Acide Formique; Other RN:8006-93-7, 82069-14-5 CAS NO: 64-18-6
FURFURAL
FURFURAL Furfural Jump to navigationJump to search Furfural Furfural.svg Furfural-3D-vdW.png Names IUPAC name Furan-2-carbaldehyde Other names Furfural, furan-2-carboxaldehyde, fural, furfuraldehyde, 2-furaldehyde, pyromucic aldehyde Identifiers CAS Number 98-01-1 check 3D model (JSmol) Interactive image ChEBI CHEBI:34768 ☒ ChEMBL ChEMBL189362 check ChemSpider 13863629 check ECHA InfoCard 100.002.389 Edit this at Wikidata KEGG C14279 check PubChem CID 7362 UNII DJ1HGI319P check CompTox Dashboard (EPA) DTXSID1020647 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula C5H4O2 Molar mass 96.085 g·mol−1 Appearance Colorless oil Odor Almond-like[1] Density 1.1601 g/mL (20 °C)[2][3] Melting point −37 °C (−35 °F; 236 K)[2] Boiling point 162 °C (324 °F; 435 K)[2] Solubility in water 83 g/L[2] Vapor pressure 2 mmHg (20 °C)[1] Magnetic susceptibility (χ) −47.1×10−6 cm3/mol Hazards Flash point 62 °C (144 °F; 335 K) Explosive limits 2.1–19.3%[1] Lethal dose or concentration (LD, LC): LD50 (median dose) 300–500 mg/kg (oral, mice)[4] LC50 (median concentration) 370 ppm (dog, 6 hr) 175 ppm (rat, 6 hr) 1037 ppm (rat, 1 hr)[5] LCLo (lowest published) 370 ppm (mouse, 6 hr) 260 ppm (rat)[5] NIOSH (US health exposure limits): PEL (Permissible) TWA 5 ppm (20 mg/m3) [skin][1] REL (Recommended) No established REL[1] IDLH (Immediate danger) 100 ppm[1] Related compounds Related Furan-2-carbaldehydes Hydroxymethylfurfural Methoxymethylfurfural Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references Furfural is an organic compound with the formula C4H3OCHO. It is a colorless liquid, although commercial samples are often brown. It has an aldehyde group attached to the 2-position of furan. It is a product of the dehydration of sugars, as occur in a variety of agricultural byproducts, including corncobs, oat, wheat bran, and sawdust. The name furfural comes from the Latin word furfur, meaning bran, referring to its usual source. Furfural is only derived from lignocellulosic biomass, i.e. its origin is non-food or non-coal/oil based. Aside from ethanol, acetic acid and sugar it is one of the oldest renewable chemicals.[6] It is also found in many processed foods and beverages. Contents 1 History 2 Properties 3 Production 4 Uses and occurrence 5 Safety 6 See also 7 References 8 External links History Furfural was first isolated in 1821 (published in 1832) by the German chemist Johann Wolfgang Döbereiner, who produced a small sample as a byproduct of formic acid synthesis.[7][8] In 1840, the Scottish chemist John Stenhouse found that the same chemical could be produced by distilling a wide variety of crop materials, including corn, oats, bran, and sawdust, with aqueous sulfuric acid; he also determined furfural's empirical formula (C5H4O2).[8] George Fownes named this oil "furfurol" in 1845 (from furfur (bran), and oleum (oil)).[9] In 1848, the French chemist Auguste Cahours determined that furfural was an aldehyde.[10] Determining the structure of furfural required some time: the furfural molecule contains a cyclic ether (furan), which tends to break open when it's treated with harsh reagents. In 1870, German chemist Adolf von Baeyer speculated (correctly) about the structure of the chemically similar compounds furan and 2-furoic acid.[11][12][13] By 1886, furfurol was being called "furfural" (short for "furfuraldehyde") and the correct chemical structure for furfural was being proposed.[14] By 1887, the German chemist Willy Marckwald had inferred that some derivatives of furfural contained a furan nucleus.[15] In 1901, the German chemist Carl Harries determined furan's structure by synthesizing it from succindialdehyde, thereby also confirming furfural's proposed structure.[16][17] Furfural remained relatively obscure until 1922,[6] when the Quaker Oats Company began mass-producing it from oat hulls.[18] Today, furfural is still produced from agricultural byproducts like sugarcane bagasse and corn cobs. The main countries producing furfural today are the Dominican Republic, South Africa and China. Properties Furfural dissolves readily in most polar organic solvents, but it is only slightly soluble in either water or alkanes. Furfural participates in the same kinds of reactions as other aldehydes and other aromatic compounds. It exhibits less aromatic character than benzene, as can be seen from the fact that furfural is readily hydrogenated to tetrahydrofurfuryl alcohol. When heated in the presence of acids, furfural irreversibly polymerizes, acting as a thermosetting polymer. Production Furfural may be obtained by the acid catalyzed dehydration of 5-carbon sugars (pentoses), particularly xylose.[19] C 5H 10O 5 → C 5H 4O 2 + 3 H 2O These sugars may be obtained from pentosans obtained from hemicellulose present in lignocellulosic biomass. Between 3% and 10% of the mass of crop residue feedstocks can be recovered as furfural, depending on the type of feedstock. Furfural and water evaporate together from the reaction mixture, and separate upon condensation. The global production capacity is about 800,000 tons as of 2012. China is the biggest supplier of furfural, and accounts for the greater part of global capacity. The other two major commercial producers are Illovo Sugar in the Republic of South Africa and Central Romana in the Dominican Republic [20] In the laboratory, furfural can be synthesized from plant material by heating with sulfuric acid[21] or other acids.[22][20] With the purpose to avoid toxic effluents, an effort to substitute sulfuric acid with easily-separable and reusable solid acid catalysts has been studied around the world.[23] In industrial production, some lignocellulosic residue remains after the removal of the furfural.[24] This residue is dried and burned to provide steam for the operation of the furfural plant. Newer and more energy efficient plants have excess residue, which is or can be used for co-generation of electricity,[25][26] cattle feed, activated carbon, mulch/fertiliser, etc. Uses and occurrence It is found in many foods: coffee (55–255 mg/kg) and whole grain bread (26 mg/kg).[4] Furfural is an important renewable, non-petroleum based, chemical feedstock. It can be converted into a variety of solvents, polymers, fuels and other useful chemicals by a range of catalytic reduction.[27] Hydrogenation of furfural provides furfuryl alcohol (FA), which is used to produce Furan resins, which are exploited in thermoset polymer matrix composites, cements, adhesives, casting resins and coatings.[28] Further hydrogenation of furfuryl alcohol leads to tetrahydrofurfuryl alcohol (THFA), which is used as a solvent in agricultural formulations and as an adjuvant to help herbicides penetrate the leaf structure. In another application as a feedstock, palladium-catalyzed decarbonylation on furfural manufactures industrially furan.[29] Another important solvent made from furfural is methyltetrahydrofuran. Furfural is used to make other furan derivatives, such as furoic acid, via oxidation,[30] and furan itself via palladium catalyzed vapor phase decarbonylation.[4] Furfural is also a specialized chemical solvent.[20] There is a good market for value added chemicals that can be obtained from furfural.[20] Safety Furfural is carcinogenic in lab animals and mutagenic in single cell organisms, but there is no data on human subjects. It is classified in IARC Group 3 due to the lack of data on humans and too few tests on animals to satisfy Group 2A/2B criteria. It is hepatotoxic.[31][32][33][34] The median lethal dose is low 650–900 mg/kg (oral, dogs), consistent with its pervasiveness in foods.[4] The Occupational Safety and Health Administration has set a permissible exposure limit for furfural at 5 ppm over an eight-hour time-weighted average (TWA), and also designates furfural as a risk for skin absorption.[1] 6.8 Furfural as flavor enhancer for drinks and food Furfural is generally recognized as a safe chemical. It is a natural degradation product of vitamin C (ascorbic acid) and also a significant product of fruit juices and wine. The longer the wine is aged, the greater the composition of furfural [22]. Regardless of the fact that furfural has an LD50 of 2330 mg/kg for dogs, its toxicity for humans is relatively low. The highest concentration of furfural is in cocoa and coffee (55–255 ppm). About 1–3 ppm of its concentration is in alcoholic beverages and 0.8–26 ppm in brown bread. It is also found in some essential oils, foods, and cosmetic products. 11.9 Furfural: An Aldehyde Furfural is an important organic chemical. Furfural itself has many applications, such as oil refining, as a bonding agent in grinding and abrasive wheels, in pharmaceuticals, and the manufacture of phenolic resins. Furfural has been addressed as one of the most important biomass-derived chemicals. It is identified as a PC for liquid fuels production and also as a precursor for LVA and levulinate esters. Initially, furfural-derived products were identified as inhibitor compounds during the valorization of the lignocellulosic materials in fermentation (Monlau et al., 2014). Furfural is mainly produced by pentose degradation and also from the thermal degradation of 5-HMF at high temperatures (200–250°C). The hemicellulosic part of the plant biomass is rich in pentoses (xylose and arbinose), hence it can be transformed into furfural. The utilization of hemicellulose for the production of furfural could be a viable alternative instead of ethanol production. Current technologies have a limited yield for furfural due to many side reactions, such as cross-polymerization with other molecules and resinification and fragmentation of furfural itself. Yemiş and Mazza (2011) proved that a microwave-assisted process provided a highly efficient conversion of xylose and xylan of hemicellulosic biomass to furfural. Sahu and Dhepe (2012) achieved a 56% yield of furfural using a solid-acid catalyzed selective method for the conversion of solid hemicelluloses. Many process parameters were optimized to minimize the formation of by-products and increase the furfural yield. A biphasic reaction system for the continuous extraction of formed furfural to decrease the side reactions resulted in higher furfural yields (Gürbüz et al., 2012; Rong et al., 2012).A furfural derivative, furfuryl alcohol, accounted for over 85% of the overall furfural market in 2013 (Grand view research, 2015). The coming years will particularly aim at technology innovations to reduce production costs and therefore increase opportunities for new applications of furfural. Furfural is a chemical compound produced by biomass rich in pentoses content in the hemicellulose as raw material, in a reaction catalysed in presence of strong acids. Is used as a potential platform to produce biofuels. In recent years, furfural has received special attention as a potential platform to produce biofuels and biochemicals. In a study conducted by the Department of Renewable Energy of the United States, furfural was selected as one of the 30 main chemicals that can be manufactured from biomass (Cai et al., 2014). Industrially, it is a very versatile chemical because of its multiple applications: utilized as a raw material to produce phenol-furfural-resins (Brown, 1959), or can be converted furfuryl alcohol, tetrahydrofurfuryl alcohol, furan, tetrahydrofuran and diols (Bhogeswararao, 2015). The Quaker Oats process is the oldest commercial form of producing furfural industrially. This process was created by the Quaker Oat company using oat cereal waste as raw material, which is mixed with sulfuric acid. The process consists in two steps, first the reaction zone in which the biomass reacted with a solution of sulfuric acid to convert the xylan fraction into furfural, then high vapour stream is introducing to the reactor to remove the furfural as fast as possible in order to avoid furfural polimerization (Marcotullio, 2011). The vapor stream from the reactor is condensed to feed the azeotropic distillation sequences in order to remove the excess of water and some by-products such as methanol and acetic acid (Marcotullio, 2011). Under the economy circle concept, the study of the reaction zone in the production of furfural is important because it allows to reduce the excessive use of water, high energy consumption and the formation of decomposition products by reducing the separation costs. In this work aims to present a novel proposal for the simultaneous optimization having as objective function TAC as economic criteria, Condition Number as a control indicator and EI99 as environmental conditions in order to improve reactor productivity in the reaction zone in the furfural production process. So far, there are no publications reported in the literature where the multi-objective optimization methodology for the furfural reaction zone is solved. 6.2.7 Furfural Furfural is the most common industrial chemical derived from lignocellulosic biomass, with an annual production volume of more than 200,000 tons [96,97]. Furfural production is exclusively based on the acid-catalyzed conversion of pentosan sugars present in agricultural and forestry residues [98]. The first commercial production of furfural was discovered at the Quaker Oats Company in 1921 [99]. At that time, the company had obtained vast quantities of oat hulls from the manufacture of oatmeal. Quaker Oats produced furfural in 50% yield (based on xylan) from hulls by treating them with dilute sulfuric acid and steam pressure [100]. As a platform molecule, some important chemicals could be produced via selective hydrogenolysis, reduction, ring opening, aldol condensation reactions, etc. (Fig. 1.19). Furfural is used as a selective solvent for refining lubricating oils and rosin, and to improve the characteristics of diesel fuel and catalytic cracker recycle stocks. It is employed extensively in the manufacture of resin-bonded abrasive wheels and for the purification of butadiene needed for the production of synthetic rubber. The manufacture of nylon requires hexamethylenediamine, of which furfural is an important source. Condensation with phenol provides furfural-phenolic resins for a variety of uses. Furfural is an organic compound with the formula C4H3OCHO. It is a colorless liquid, although commercial samples are often brown. It has an aldehyde group attached to the 2-position of furan. It is a product of the dehydration of sugars, as occur in a variety of agricultural byproducts, including corncobs, oat, wheat bran, and sawdust. The name furfural comes from the Latin word furfur, meaning bran, referring to its usual source. Furfural is only derived from lignocellulosic biomass, i.e. its origin is non-food or non-coal/oil based. Aside from ethanol, acetic acid and sugar it is one of the oldest renewable chemicals.[6] It is also found in many processed foods and beverages. Contents 1 History 2 Properties 3 Production 4 Uses and occurrence 5 Safety 6 See also 7 References 8 External links History Furfural was first isolated in 1821 (published in 1832) by the German chemist Johann Wolfgang Döbereiner, who produced a small sample as a byproduct of formic acid synthesis.[7][8] In 1840, the Scottish chemist John Stenhouse found that the same chemical could be produced by distilling a wide variety of crop materials, including corn, oats, bran, and sawdust, with aqueous sulfuric acid; he also determined furfural's empirical formula (C5H4O2).[8] George Fownes named this oil "furfurol" in 1845 (from furfur (bran), and oleum (oil)).[9] In 1848, the French chemist Auguste Cahours determined that furfural was an aldehyde.[10] Determining the structure of furfural required some time: the furfural molecule contains a cyclic ether (furan), which tends to break open when it's treated with harsh reagents. In 1870, German chemist Adolf von Baeyer speculated (correctly) about the structure of the chemically similar compounds furan and 2-furoic acid.[11][12][13] By 1886, furfurol was being called "furfural" (short for "furfuraldehyde") and the correct chemical structure for furfural was being proposed.[14] By 1887, the German chemist Willy Marckwald had inferred that some derivatives of furfural contained a furan nucleus.[15] In 1901, the German chemist Carl Harries determined furan's structure by synthesizing it from succindialdehyde, thereby also confirming furfural's proposed structure.[16][17] Furfural remained relatively obscure until 1922,[6] when the Quaker Oats Company began mass-producing it from oat hulls.[18] Today, furfural is still produced from agricultural byproducts like sugarcane bagasse and corn cobs. The main countries producing furfural today are the Dominican Republic, South Africa and China. Properties Furfural dissolves readily in most polar organic solvents, but it is only slightly soluble in either water or alkanes. Furfural participates in the same kinds of reactions as other aldehydes and other aromatic compounds. It exhibits less aromatic character than benzene, as can be seen from the fact that furfural is readily hydrogenated to tetrahydrofurfuryl alcohol. When heated in the presence of acids, furfural irreversibly polymerizes, acting as a thermosetting polymer. Production Furfural may be obtained by the acid catalyzed dehydration of 5-carbon sugars (pentoses), particularly xylose.[19] C 5H 10O 5 → C 5H 4O 2 + 3 H 2O These sugars may be obtained from pentosans obtained from hemicellulose present in lignocellulosic biomass. Between 3% and 10% of the mass of crop residue feedstocks can be recovered as furfural, depending on the type of feedstock. Furfural and water evaporate together from the reaction mixture, and separate upon condensation. The global production capacity is about 800,000 tons as of 2012. China is the biggest supplier of furfural, and accounts for the greater part of global capacity. The other two major commercial producers are Illovo Sugar in the Republic of South Africa and Central Romana in the Dominican Republic [20] In the laboratory, furfural can be synthesized from plant material by heating with sulfuric acid[21] or other acids.[22][20] With the purpose to avoid toxic effluents, an effort to substitute sulfuric acid with easily-separable and reusable solid acid catalysts has been studied around the world.[23] In industrial production, some lignocellulosic residue remains after the removal of the furfural.[24] This residue is dried and burned to provide steam for the operation of the furfural plant. Newer and more energy efficient plants have excess residue, which is or can be used for co-generation of electricity,[25][26] cattle feed, activated carbon, mulch/fertiliser, etc. Uses and occurrence It is found in many foods: coffee (55–255 mg/kg) and whole grain bread (26 mg/kg).[4] Furfural is an important renewable, non-petroleum based, chemical feedstock. It can be converted into a variety of solvents, polymers, fuels and other useful chemicals by a range of catalytic reduction.[27] Hydrogenation of furfural provides furfuryl alcohol (FA), which is used to produce Furan resins, which are exploited in thermoset polymer matrix composites, cements, adhesives, casting resins and coatings.[28] Further hydrogenation of furfuryl alcohol leads to tetrahydrofurfuryl alcohol (THFA), which is used as a solvent in agricultural formulations and as an adjuvant to help herbicides penetrate the leaf structure. In another application as a feedstock, palladium-catalyzed decarbonylation on furfural manufactures industrially furan.[29] Another important solvent made from furfural is methyltetrahydrofuran. Furfural is used to make other furan derivatives, such as furoic acid, via oxidation,[30] and furan itself via palladium catalyzed vapor phase decarbonylation.[4] Furfural is also a specialized chemical solvent.[20] There is a good market for value added chemicals that can be obtained from furfural.[20] Safety Furfural is carcinogenic in lab animals and mutagenic in single cell organisms, but there is no data on human subjects. It is classified in IARC Group 3 due to the lack of data on humans and too few tests on animals to satisfy Group 2A/2B criteria. It is hepatotoxic.[31][32][33][34] The median lethal dose is low 650–900 mg/kg (oral, dogs), consistent with its pervasiveness in foods.[4] The Occupational Safety and Health Administration has set a permissible exposure limit for furfural at 5 ppm over an eight-hour time-weighted average (TWA), and also designates furfural as a risk for skin absorption.[1] 6.8 Furfural as flavor enhancer for drinks and food Furfural is generally recognized as a safe chemical. It is a natural degradation product of vitamin C (ascorbic acid) and also a significant product of fruit juices and wine. The longer the wine is aged, the greater the composition of furfural [22]. Regardless of the fact that furfural has an LD50 of 2330 mg/kg for dogs, its toxicity for humans is relatively low. The highest concentration of furfural is in cocoa and coffee (55–255 ppm). About 1–3 ppm of its concentration is in alcoholic beverages and 0.8–26 ppm in brown bread. It is also found in some essential oils, foods, and cosmetic products. 11.9 Furfural: An Aldehyde Furfural is an important organic chemical. Furfural itself has many applications, such as oil refining, as a bonding agent in grinding and abrasive wheels, in pharmaceuticals, and the manufacture of phenolic resins. Furfural has been addressed as one of the most important biomass-derived chemicals. It is identified as a PC for liquid fuels production and also as a precursor for LVA and levulinate esters. Initially, furfural-derived products were identified as inhibitor compounds during the valorization of the lignocellulosic materials in fermentation (Monlau et al., 2014). Furfural is mainly produced by pentose degradation and also from the thermal degradation of 5-HMF at high temperatures (200–250°C). The hemicellulosic part of the plant biomass is rich in pentoses (xylose and arbinose), hence it can be transformed into furfural. The utilization of hemicellulose for the production of furfural could be a viable alternative instead of ethanol production. Current technologies have a limited yield for furfural due to many side reactions, such as cross-polymerization with other molecules and resinification and fragmentation of furfural itself. Yemiş and Mazza (2011) proved that a microwave-assisted process provided a highly efficient conversion of xylose and xylan of hemicellulosic biomass to furfural. Sahu and Dhepe (2012) achieved a 56% yield of furfural using a solid-acid catalyzed selective method for the conversion of solid hemicelluloses. Many process parameters were optimized to minimize the formation of by-products and increase the furfural yield. A biphasic reaction system for the continuous extraction of formed furfural to decrease the side reactions resulted in higher furfural yields (Gürbüz et al., 2012; Rong et al., 2012).A furfural derivative, furfuryl alcohol, accounted for over 85% of the overall furfural market in 2013 (Grand view research, 2015). The coming years will particularly aim at technology innovations to reduce production costs and therefore increase opportunities for new applications of furfural. Furfural is a chemical compound produced by biomass rich in pentoses content in the hemicellulose as raw material, in a reaction catalysed in presence of strong acids. Is used as a potential platform to produce biofuels. In recent years, furfural has received special attention as a potential platform to produce biofuels and biochemicals. In a study conducted by the Department of Renewable Energy of the United States, furfural was selected as one of the 30 main chemicals that can be manufactured from biomass (Cai et al., 2014). Industrially, it is a very versatile chemical because of its multiple applications: utilized as a raw material to produce phenol-furfural-resins (Brown, 1959), or can be converted furfuryl alcohol, tetrahydrofurfuryl alcohol, furan, tetrahydrofuran and diols (Bhogeswararao, 2015). The Quaker Oats process is the oldest commercial form of producing furfural industrially. This process was created by the Quaker Oat company using oat cereal waste as raw material, which is mixed with sulfuric acid. The process consists in two steps, first the reaction zone in which the biomass reacted with a solution of sulfuric acid to convert the xylan fraction into furfural, then high vapour stream is introducing to the reactor to remove the furfural as fast as possible in order to avoid furfural polimerization (Marcotullio, 2011). The vapor stream from the reactor is condensed to feed the azeotropic distillation sequences in order to remove the excess of water and some by-products such as methanol and acetic acid (Marcotullio, 2011). Under the economy circle concept, the study of the reaction zone in the production of furfural is important because it allows to reduce the excessive use of water, high energy consumption and the formation of decomposition products by reducing the separation costs. In this work aims to present a novel proposal for the simultaneous optimization having as objective function TAC as economic criteria, Condition Number as a control indicator and EI99 as environmental conditions in order to improve reactor productivity in the reaction zone in the furfural production process. So far, there are no publications reported in the literature where the multi-objective optimization methodology for the furfural reaction zone is solved. 6.2.7 Furfural Furfural is the most common industrial chemical derived from lignocellulosic biomass, with an annual production volume of more than 200,000 tons [96,97]. Furfural production is exclusively based on the acid-catalyzed conversion of pentosan sugars present in agricultural and forestry residues [98]. The first commercial production of furfural was discovered at the Quaker Oats Company in 1921 [99]. At that time, the company had obtained vast quantities of oat hulls from the manufacture of oatmeal. Quaker Oats produced furfural in 50% yield (based on xylan) from hulls by treating them with dilute sulfuric acid and steam pressure [100]. As a platform molecule, some important chemicals could be produced via selective hydrogenolysis, reduction, ring opening, aldol condensation reactions, etc. (Fig. 1.19). Furfural is used as a selective solvent for refining lubricating oils and rosin, and to improve the characteristics of diesel fuel and catalytic cracker recycle stocks. It is employed extensively in the manufacture of resin-bonded abrasive wheels and for the purification of butadiene needed for the production of synthetic rubber. The manufacture of nylon requires hexamethylenediamine, of which furfural is an important source. Condensation with phenol provides furfural-phenolic resins for a variety of uses.
FURFURYL ALCOHOL
FURFURYL ALCOHOL Furfuryl alcohol Jump to navigationJump to search Furfuryl alcohol[1] Structural formula of furfuryl alcohol Ball-and-stick model of the furfuryl alcohol molecule Names Preferred IUPAC name (Furan-2-yl)methanol Other names Furan-2-ylmethanol Furfuryl alcohol 2-Furanmethanol 2-Furancarbinol 2-(Hydroxymethyl)furan Identifiers CAS Number 98-00-0 check 3D model (JSmol) Interactive image ChEBI CHEBI:207496 check ChEMBL ChEMBL308187 check ChemSpider 7083 check ECHA InfoCard 100.002.388 Edit this at Wikidata PubChem CID 7361 UNII D582054MUH check CompTox Dashboard (EPA) DTXSID2025347 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula C5H6O2 Molar mass 98.10 g/mol Appearance colorless liquid Odor burning odor[2] Density 1.128 g/cm3 Melting point −29 °C (−20 °F; 244 K) Boiling point 170 °C (338 °F; 443 K) Solubility in water miscible Hazards Safety data sheet External MSDS NFPA 704 (fire diamond) NFPA 704 four-colored diamond 231 Flash point 65 °C; 149 °F; 338 K [2] Explosive limits 1.8% - 16.3%[2] Lethal dose or concentration (LD, LC): LC50 (median concentration) 397 ppm (mouse, 6 hr) 85 ppm (rat, 6 hr) 592 ppm (rat, 1 hr)[3] LCLo (lowest published) 597 ppm (mouse, 6 hr)[3] NIOSH (US health exposure limits): PEL (Permissible) TWA 50 ppm (200 mg/m3)[2] REL (Recommended) TWA 10 ppm (40 mg/m3) ST 15 ppm (60 mg/m3) [skin][2] IDLH (Immediate danger) 75 ppm[2] Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). check verify (what is check☒ ?) Infobox references Furfuryl alcohol is an organic compound containing a furan substituted with a hydroxymethyl group. It is a colorless liquid, but aged samples appear amber. It possesses a faint odor of burning and a bitter taste. It is miscible with but unstable in water. It is soluble in common organic solvents.[4] Contents 1 Synthesis 2 Reactions 3 Applications 3.1 Craft uses 4 Safety 5 See also 6 References 7 External links Synthesis Furfuryl alcohol is manufactured industrially by hydrogenation of furfural, which is itself typically produced from waste bio-mass such as corncobs or sugar cane bagasse. As such furfuryl alcohol may be considered a green chemical.[5] One-pot systems have been investigated to produce furfuryl alcohol directly from xylose using solid acid catalysts.[6] Reactions It undergoes many reactions including Diels-Alder additions to electrophilic alkenes and alkynes. Hydroxymethylation gives 1,5-bis(hydroxymethyl)furan. Hydrolysis gives levulinic acid. Upon treatment with acids, heat and/or catalysts, furfuryl alcohol can be made to polymerize into a resin, poly(furfuryl alcohol). Hydrogenation of furfuryl alcohol can proceed to give hydroxymethyl derivative of tetrahydrofuran and 1,5-pentanediol. The etherification reaction of furfuryl alcohol with alkyl or aryl halide (e.g. benzyl chloride) in the liquid-liquid-liquid triphase system with the help of a phase transfer catalyst also reported.[7] Applications The primary use of furfuryl alcohol is as a monomer for the synthesis of furan resins.[4][8] These polymers are used in thermoset polymer matrix composites, cements, adhesives, coatings and casting/foundry resins. Polymerization involves an acid-catalyzed polycondensation, usually giving a black cross-linked product.[9] A highly simplified representation is shown below. Furan resin.svg Craft uses Furfuryl alcohol has been used in rocketry as a fuel which ignites hypergolically (immediately and energetically in contact) with white fuming nitric acid or red fuming nitric acid oxidizer.[10] The use of hypergolics avoids the need for an igniter. In late 2012, Spectra, a concept liquid rocket engine using white fuming nitric acid as the oxidizer to furfuryl alcohol fuel was static tested by Copenhagen Suborbitals.[11][12] Because of its low molecular weight, furfuryl alcohol can impregnate the cells of wood, where it can be polymerized and bonded with the wood by heat, radiation, and/or catalysts or additional reactants. The treated wood has improved moisture-dimensional stability, hardness, and decay and insect resistance; catalysts can include zinc chloride, citric, and formic acid, as well as borates.[13][14] Safety The median lethal dose for furfuryl alcohol ranges from 160 to 400 mg/kg (mouse or rabbit, oral). Furfural alcohol resin. Furfuryl alcohol resin is produced by self polycondensation of furfuryl alcohol monomer which reacts with the active a-hydrogen of another furfuryl alcohol molecule in the presence of acid catalyst to from the polycondensation resin. Reaction formula is shown in follow. Furfuryl alcohol-based resins are the most important industrial furan resins in terms of usage and volume.[8] The final cross-linked products exhibit outstanding properties and characteristics. Furfural replaces formaldehyde in the conventional production of phenolic resins. It reacts easily with phenol in the presence of an alkaline catalyst to form a novolac phenol-furfural resin. (Novolac phenolic resin requires an acid catalyst.) Furfuryl alcohol readily resinifies or homopolymerizes in the presence of an acid catalyst [such as mineral acids, organic acids, Lewis acids (boron halides, e.g., BF3), and acyl halides] to produce liquid linear chains (oligomers). These chains consist primarily of dimers and trimers that have methylene linkages between the furan rings. The process essentially is a methylolation involving the condensation of the methylol group of one furfuryl alcohol molecule with another molecule at the fifth position (Figure 3-4). The furfuryl alcohol resinification process is highly exothermic; the necessary temperature control is accomplished by cooling via either reflux or an external cooling fluid. The process is carried to a predetermined viscosity end point, and the reaction is stopped by adjusting the pH to between 5 and 8. The resulting liquid resin has a shelf life of more than 6 months. Furfuryl alcohol also undergoes copolymerization with aldehydes such as formaldehyde and furfural, and with phenols and urea in the presence of an aldehyde. Since the introduction of furan NO-BAKE foundry binders, furfuryl alcohol has grown to the largest volume derivative of furfural. In the seventies Quaker's chemical division decided to build an additional furfuryl alcohol production facilityin Geel, nearby Antwerp (Belgium) to serve the expanding demand throughout the world. In 1998, this Belgian facility became an independent entity - nominated TransFurans Chemicals. The selective Cu-catalyzed hydrogenation of furfural is the sole industrial route for furfuryl alcohol production. This process can be performed in gas or liquid phase. TransFurans Chemicals operates world's most effective and biggest furfural hydrogenation plant. The incoming furfural is produced at the world's largest furfural facility, Central Romana Corporation. The company is close to the Antwerp Seaport for export to the Asian and American continent; the central location of Belgium favors TransFurans Chemicals to supply the European customers. International Furan Chemicals has the exclusive use and distribution rights of TFC's furfuryl alcohol output of some 40,000 tons. Today the wide spread use of furfuryl alcohol in foundry resins is the principal outlet of this renewable chemical. Nevertheless, the low viscosity and high reactivity of furfuryl alcohol and the outstanding chemical, mechanical and thermal properties of its polymers have led to successful applications of furfuryl alcohol in other fields than the foundry industry. By controlled polymerisation polyfurfuryl alcohol (PFA) can be produced. PFA is an engineering thermoset resin with applications in fibre reinforced plastics, adhesives, anti-corrosive and carbon products. Furfuryl alcohol is also the chemical substrate in the production of tetrahydrofurfuryl alcohol, levulinic acid, 3,4 dihydro 2H pyran, pentane diols and precursor molecules for pharmaceutical intermediates. Furfuryl alcohol is not an oil derived chemical. The basic raw materials for its manufacture are waste vegetable materials such as sugar cane bagasse, oat hulls, corn cobs and rice hulls. This reactive alcohol plays a vital role in the production of foundry sand binders. For over 40 years it has been extensively used to produce cores and molds for metal casting. No wonder that the major part of furfuryl alcohol, manufactured at TransFurans Chemicals is purchased by foundry binder suppliers. Of course the remarkable properties of this chemical, such as low viscosity, high reactivity and excellent solvent characteristics have led to success in other fields. Foundry industry Furfuryl alcohol is the major ingredient in FURAN foundry binders [1]. The flexibility of furfuryl alcohol as a binder base is enormous. Today furfuryl alcohol is used in binders for HOT-BOX, WARM BOX and gas hardened processes as well as in the traditional FURAN-NO-BAKE system. Furan NO-BAKE (FNB) was introduced in 1958. It is suitable for making all types of metal castings in all sizes, and particularly used for the production of molds and larger cores. This acid catalyzed cold setting binder consist of a hardening catalysts such as sulfuric acids, sulfonic acids and phosphoric acids and of a reactive furan-type resin. FNB is known for its superior shakeout characteristics and the sand can be reused by thermal and/or mechanical reclamation [2]. Furan HOT BOX process uses furan resins in combination with a latent acid catalysts, e.g. ammonium salts. The WARM BOX process is operated at lower temperatures and was developed by the Quaker Oats Company for the rapid production of cores in existing hot box equipment. This type of furan binder contains more furfuryl alcohol than in hot box furan binders. A latent copper salt catalyst is used to cure the binder very rapidly upon heating The Furan SO2 process is a gas cured binder system for the rapid production of small moulds and cores. Curing of the furanic resin occurs right away, when the sand mix is exposed to SO2 gas at room temperature. Furfuryl Alcohol and Furan Resins Chemical Economics Handbook Published March 2020 The majority of furfuryl alcohol is used in the production of furan resins for foundry sand binders in the metal casting industry. Currently, furfuryl alcohol is used mainly in binders for the traditional furan no-bake system and in smaller quantities in furan hot-box, warm-box, and gas-hardened processes. In its main application, the foundry business, furfuryl alcohol competes primarily with phenol, the feedstock for phenolic resins. The following pie chart shows world consumption of furfuryl alcohol: The production and use of furfuryl alcohol is centered in China. Low-cost production in China forced most of the industry in North America, Western Europe, and Japan to shutter operations in the 1990s. China has also captured most of the global foundry business. Little change is expected in the near future. Any growth in the global industry will depend on activity in China. China continues to be the world’s largest producer and consumer of furfuryl alcohol, accounting for more than 85% of worldwide capacity, 80% of production, and about 60% of global consumption in 2019. Since 2000, a number of foundries have relocated to China, which has led to increased domestic demand for furan resins, especially from the automotive, windmill, and machinery industries. However, it is expected that Chinese demand for furan resins in the heavy casting industry will grow at a more moderate rate in the future. It is estimated that about 90% of worldwide demand for furfuryl alcohol in 2019 was used for the production of furan resins. The remaining applications include tetrahydrofurfuryl alcohol (THFA), and use in solvents, flavor and fragrance chemicals, pesticides, and pharmaceuticals. THFA is used mainly as a specialty solvent or chemical intermediate, with its primary end markets being agricultural chemicals, coatings, and cleaning solutions. For more detailed information, see the table of contents, shown below. IHS Markit’s Chemical Economics Handbook –Furfuryl Alcohol and Furan Resins is the comprehensive and trusted guide for anyone seeking information on this industry. This latest report details global and regional information, including Key benefits IHS Markit’s Chemical Economics Handbook –Furfuryl Alcohol and Furan Resins has been compiled using primary interviews with key suppliers and organizations, and leading representatives from the industry in combination with IHS Markit’s unparalleled access to upstream and downstream market intelligence and expert insights into industry dynamics, trade, and economics. Furfuryl alcohol is an organic compound containing a furan substituted with a hydroxymethyl group. It is a colorless liquid, but aged samples appear amber. It possesses a faint odor of burning and a bitter taste. It is miscible with but unstable in water. It is soluble in common organic solvents.[4] Contents 1 Synthesis 2 Reactions 3 Applications 3.1 Craft uses 4 Safety 5 See also 6 References 7 External links Synthesis Furfuryl alcohol is manufactured industrially by hydrogenation of furfural, which is itself typically produced from waste bio-mass such as corncobs or sugar cane bagasse. As such furfuryl alcohol may be considered a green chemical.[5] One-pot systems have been investigated to produce furfuryl alcohol directly from xylose using solid acid catalysts.[6] Reactions It undergoes many reactions including Diels-Alder additions to electrophilic alkenes and alkynes. Hydroxymethylation gives 1,5-bis(hydroxymethyl)furan. Hydrolysis gives levulinic acid. Upon treatment with acids, heat and/or catalysts, furfuryl alcohol can be made to polymerize into a resin, poly(furfuryl alcohol). Hydrogenation of furfuryl alcohol can proceed to give hydroxymethyl derivative of tetrahydrofuran and 1,5-pentanediol. The etherification reaction of furfuryl alcohol with alkyl or aryl halide (e.g. benzyl chloride) in the liquid-liquid-liquid triphase system with the help of a phase transfer catalyst also reported.[7] Applications The primary use of furfuryl alcohol is as a monomer for the synthesis of furan resins.[4][8] These polymers are used in thermoset polymer matrix composites, cements, adhesives, coatings and casting/foundry resins. Polymerization involves an acid-catalyzed polycondensation, usually giving a black cross-linked product.[9] A highly simplified representation is shown below. Furan resin.svg Craft uses Furfuryl alcohol has been used in rocketry as a fuel which ignites hypergolically (immediately and energetically in contact) with white fuming nitric acid or red fuming nitric acid oxidizer.[10] The use of hypergolics avoids the need for an igniter. In late 2012, Spectra, a concept liquid rocket engine using white fuming nitric acid as the oxidizer to furfuryl alcohol fuel was static tested by Copenhagen Suborbitals.[11][12] Because of its low molecular weight, furfuryl alcohol can impregnate the cells of wood, where it can be polymerized and bonded with the wood by heat, radiation, and/or catalysts or additional reactants. The treated wood has improved moisture-dimensional stability, hardness, and decay and insect resistance; catalysts can include zinc chloride, citric, and formic acid, as well as borates.[13][14] Safety The median lethal dose for furfuryl alcohol ranges from 160 to 400 mg/kg (mouse or rabbit, oral). Furfural alcohol resin. Furfuryl alcohol resin is produced by self polycondensation of furfuryl alcohol monomer which reacts with the active a-hydrogen of another furfuryl alcohol molecule in the presence of acid catalyst to from the polycondensation resin. Reaction formula is shown in follow. Furfuryl alcohol-based resins are the most important industrial furan resins in terms of usage and volume.[8] The final cross-linked products exhibit outstanding properties and characteristics. Furfural replaces formaldehyde in the conventional production of phenolic resins. It reacts easily with phenol in the presence of an alkaline catalyst to form a novolac phenol-furfural resin. (Novolac phenolic resin requires an acid catalyst.) Furfuryl alcohol readily resinifies or homopolymerizes in the presence of an acid catalyst [such as mineral acids, organic acids, Lewis acids (boron halides, e.g., BF3), and acyl halides] to produce liquid linear chains (oligomers). These chains consist primarily of dimers and trimers that have methylene linkages between the furan rings. The process essentially is a methylolation involving the condensation of the methylol group of one furfuryl alcohol molecule with another molecule at the fifth position (Figure 3-4). The furfuryl alcohol resinification process is highly exothermic; the necessary temperature control is accomplished by cooling via either reflux or an external cooling fluid. The process is carried to a predetermined viscosity end point, and the reaction is stopped by adjusting the pH to between 5 and 8. The resulting liquid resin has a shelf life of more than 6 months. Furfuryl alcohol also undergoes copolymerization with aldehydes such as formaldehyde and furfural, and with phenols and urea in the presence of an aldehyde. Since the introduction of furan NO-BAKE foundry binders, furfuryl alcohol has grown to the largest volume derivative of furfural. In the seventies Quaker's chemical division decided to build an additional furfuryl alcohol production facilityin Geel, nearby Antwerp (Belgium) to serve the expanding demand throughout the world. In 1998, this Belgian facility became an independent entity - nominated TransFurans Chemicals. The selective Cu-catalyzed hydrogenation of furfural is the sole industrial route for furfuryl alcohol production. This process can be performed in gas or liquid phase. TransFurans Chemicals operates world's most effective and biggest furfural hydrogenation plant. The incoming furfural is produced at the world's largest furfural facility, Central Romana Corporation. The company is close to the Antwerp Seaport for export to the Asian and American continent; the central location of Belgium favors TransFurans Chemicals to supply the European customers. International Furan Chemicals has the exclusive use and distribution rights of TFC's furfuryl alcohol output of some 40,000 tons. Today the wide spread use of furfuryl alcohol in foundry resins is the principal outlet of this renewable chemical. Nevertheless, the low viscosity and high reactivity of furfuryl alcohol and the outstanding chemical, mechanical and thermal properties of its polymers have led to successful applications of furfuryl alcohol in other fields than the foundry industry. By controlled polymerisation polyfurfuryl alcohol (PFA) can be produced. PFA is an engineering thermoset resin with applications in fibre reinforced plastics, adhesives, anti-corrosive and carbon products. Furfuryl alcohol is also the chemical substrate in the production of tetrahydrofurfuryl alcohol, levulinic acid, 3,4 dihydro 2H pyran, pentane diols and precursor molecules for pharmaceutical intermediates. Furfuryl alcohol is not an oil derived chemical. The basic raw materials for its manufacture are waste vegetable materials such as sugar cane bagasse, oat hulls, corn cobs and rice hulls. This reactive alcohol plays a vital role in the production of foundry sand binders. For over 40 years it has been extensively used to produce cores and molds for metal casting. No wonder that the major part of furfuryl alcohol, manufactured at TransFurans Chemicals is purchased by foundry binder suppliers. Of course the remarkable properties of this chemical, such as low viscosity, high reactivity and excellent solvent characteristics have led to success in other fields. Foundry industry Furfuryl alcohol is the major ingredient in FURAN foundry binders [1]. The flexibility of furfuryl alcohol as a binder base is enormous. Today furfuryl alcohol is used in binders for HOT-BOX, WARM BOX and gas hardened processes as well as in the traditional FURAN-NO-BAKE system. Furan NO-BAKE (FNB) was introduced in 1958. It is suitable for making all types of metal castings in all sizes, and particularly used for the production of molds and larger cores. This acid catalyzed cold setting binder consist of a hardening catalysts such as sulfuric acids, sulfonic acids and phosphoric acids and of a reactive furan-type resin. FNB is known for its superior shakeout characteristics and the sand can be reused by thermal and/or mechanical reclamation [2]. Furan HOT BOX process uses furan resins in combination with a latent acid catalysts, e.g. ammonium salts. The WARM BOX process is operated at lower temperatures and was developed by the Quaker Oats Company for the rapid production of cores in existing hot box equipment. This type of furan binder contains more furfuryl alcohol than in hot box furan binders. A latent copper salt catalyst is used to cure the binder very rapidly upon heating The Furan SO2 process is a gas cured binder system for the rapid production of small moulds and cores. Curing of the furanic resin occurs right away, when the sand mix is exposed to SO2 gas at room temperature. Furfuryl Alcohol and Furan Resins Chemical Economics Handbook Published March 2020 The majority of furfuryl alcohol is used in the production of furan resins for foundry sand binders in the metal casting industry. Currently, furfuryl alcohol is used mainly in binders for the traditional furan no-bake system and in smaller quantities in furan hot-box, warm-box, and gas-hardened processes. In its main application, the foundry business, furfuryl alcohol competes primarily with phenol, the feedstock for phenolic resins. The following pie chart shows world consumption of furfuryl alcohol: The production and use of furfuryl alcohol is centered in China. Low-cost production in China forced most of the industry in North America, Western Europe, and Japan to shutter operations in the 1990s. China has also captured most of the global foundry business. Little change is expected in the near future. Any growth in the global industry will depend on activity in China. China continues to be the world’s largest producer and consumer of furfuryl alcohol, accounting for more than 85% of worldwide capacity, 80% of production, and about 60% of global consumption in 2019. Since 2000, a number of foundries have relocated to China, which has led to increased domestic demand for furan resins, especially from the automotive, windmill, and machinery industries. However, it is expected that Chinese demand for furan resins in the heavy casting industry will grow at a more moderate rate in the future. It is estimated that about 90% of worldwide demand for furfuryl alcohol in 2019 was used for the production of furan resins. The remaining applications include tetrahydrofurfuryl alcohol (THFA), and use in solvents, flavor and fragrance chemicals, pesticides, and pharmaceuticals. THFA is used mainly as a specialty solvent or chemical intermediate, with its primary end markets being agricultural chemicals, coatings, and cleaning solutions. For more detailed information, see the table of contents, shown below. IHS Markit’s Chemical Economics Handbook –Furfuryl Alcohol and Furan Resins is the comprehensive and trusted guide for anyone seeking information on this industry. This latest report details global and regional information, including Key benefits IHS Markit’s Chemical Economics Handbook –Furfuryl Alcohol and Furan Resins has been compiled using primary interviews with key suppliers and organizations, and leading representatives from the industry in combination with IHS Markit’s unparalleled access to upstream and downstream market intelligence and expert insights into industry dynamics, trade, and economics.
FURFURYL ALCOHOL
Furfuryl alcohol is an organic compound containing a furan substituted with a hydroxymethyl group.
Furfuryl alcohol appears as a clear colorless liquid.


CAS Number: 98-00-0
EC Number: 202-626-1
MDL number: MFCD00003252
Molecular Formula: C5H6O2


Furfuryl Alcohol is a renewable material derived from furfural, produced from hydrolysed biomass waste.
Furfuryl alcohol is an organic compound containing a furan substituted with a hydroxymethyl group.
Furfuryl Alcohol is a colorless liquid, but aged samples appear amber.


Furfuryl Alcohol possesses a faint odor of burning and a bitter taste.
Furfuryl Alcohol is miscible with but unstable in water.
Furfuryl Alcohol is soluble in common organic solvents.


Because of its low molecular weight, furfuryl alcohol can impregnate the cells of wood, where it can be polymerized and bonded with the wood by heat, radiation, and/or catalysts or additional reactants.
The treated wood (e.g. "Kebony") has improved moisture-dimensional stability, hardness, and decay and insect resistance; catalysts can include zinc chloride, citric, and formic acid, as well as borates.


Furfuryl alcohol appears as a clear colorless liquid.
The flash point of Furfuryl Alcohol is 167 °F.
The boiling point of Furfuryl Alcohol is 171 °F.


Furfuryl Alcohol is denser than water.
Furfuryl alcohol is a furan bearing a hydroxymethyl substituent at the 2-position.
Furfuryl Alcohol has a role as a Maillard reaction product.


Furfuryl Alcohol is a primary alcohol and a member of furans.
Furfuryl alcohol is a natural product found in Prunus mume, Campsis grandiflora, and other organisms with data available.
Furfuryl Alcohol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Furfuryl Alcohol acts as a solvent.
Furfuryl alcohol is very unstable when contacted with even low levels of strong acids.
Furfuryl alcohol is a clear colorless organic liquid when pure, but becomes amber upon prolonged exposure to light and air.


Furfuryl alcohol, produced in Argentina, is produced using a catalytic hydrogenation process at high pressure, starting from furfural.
Furfuryl alcohol has a purity of 98.5%.
Furfuryl alcohol is derived from furan and differs from the latter by an additional hydroxymethyl group.


Furfuryl Alcohol forms on disproportionation of furfural and is a colorless to yellow liquid that is readily soluble in organic solvents (ethanol, benzene) but insoluble in kerosene.
Furfuryl Alcohol is reactive in many ways.


Furfuryl alcohol is a chemical compound containing furan substituted with a hydroxymethyl group.
Furfuryl Alcohol is manufactured primarily by the hydrogenation of furfural, which is produced from organic biomass material such as corncobs, sugarcane bagasse and rice hulls.


Visually, furfuryl alcohol is a colorless liquid, but it can become amber in color when aged.
Furfuryl alcohol is considered to be highly reactive and plays an active role in the production of binder compounds.
Some of the most renowned properties of this chemical are its low viscosity and excellent solvent characteristics.


These attributes have made furfuryl alcohol an essential chemical in numerous industries.
Furfuryl alcohol is an organic compound containing a furan substituted with a hydroxymethyl group.
Furfuryl Alcohol is a colorless liquid, but aged samples appear amber.


Furfuryl Alcohol is characterized by a faint burning smell and a bitter taste.
Furfuryl Alcohol is miscible with water, but is unstable in water.
Furfuryl Alcohol is soluble in common organic solvents.


Furfuryl Alcohol is manufactured by the hydrogenation (catalytic reduction) of furfural.
Furfuryl Alcohol’s polymerization characteristics have opened up opportunities in the wood treatment/modification industry: when treated with FA, the characteristics of ‘softwoods’ are altered so as to make the woods more valuable.


One of the characteristics of treated/modified wood is its resistance to infestations (a genuine alternative to replace CCA – copper chromium arsenic – treaded wood!).
Another one is Furfuryl Alcohol's increased hardness in comparison with untreated wood (a genuine alternative to replace tropical hardwood).


The first two commercial technologies/processes for the “furfylation” of wood have been introduced and their market acceptance is growing (and with it the demand for Furfuryl Alcohol).
This presents an excellent opportunity in that the tropical hard wood and CCA treated wood substitution markets are multi-billion dollar businesses.



USES and APPLICATIONS of FURFURYL ALCOHOL:
Key Applications of Furfuryl Alcohol: Corrosion Resistant; Paint Stripper; Organic Coatings; Green Coatings; Reactive Solvent; Pharmaceutical Precursor
Furfuryl Alcohol is used in the synthesis of pharmaceutical, agricultural and industrial chemicals furfural alcohol is used in make sand molds for metal castings


Furfuryl alcohol has been used as an analytical reference standard for the determination of furfuryl alcohol in:Transformer or rectifier oils by solid-phase extraction (SPE), liquid-liquid extraction (LLE) and high performance liquid chromatography (HPLC) equipped with variable ultraviolet (UV) detector.
Furfuryl Alcohol is used Adhesives, Wetting agents, Anti-corrosion coating, Solvents, Thinner, Organic raw material.


Furfuryl Alcohol is used to make a variety of furan polymers, used in sealants and cements or in combination with other chemicals to make urea-formaldehyde or phenolic resins.
Furfuryl Alcohol is also used as a flavourant.


Furfuryl Alcohol can be used as a solvent, but it’s more often used as an ingredient in the manufacture of various chemical products such as: Furan resins, especially foundry resin, which is used as binder of the sand core.
Furfuryl Alcohol is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


Furfuryl Alcohol is used in the following products: coating products.
Release to the environment of Furfuryl Alcohol can occur from industrial use: formulation of mixtures.
Other release to the environment of Furfuryl Alcohol is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).


Furfuryl Alcohol is used in the following products: polymers, laboratory chemicals and coating products.
Release to the environment of Furfuryl Alcohol can occur from industrial use: formulation of mixtures.
Furfuryl Alcohol is used in the following products: polymers and laboratory chemicals.


Furfuryl Alcohol is used for the manufacture of: chemicals and plastic products.
Release to the environment of Furfuryl Alcohol can occur from industrial use: for thermoplastic manufacture, in processing aids at industrial sites and in the production of articles.


Release to the environment of Furfuryl Alcohol can occur from industrial use: manufacturing of the substance.
Furfuryl alcohol is used in the synthesis of continuous titanium carbide nanofibers/nanoribbon.
Furfuryl Alcohol is used in the following areas: scientific research and development.


Furfuryl alcohol (FuOH, C4H3OCH2OH, 2-furylmethanol, 2-furancarbinol) has applications in the fabrication of foundry resins, the ingredient production of P-series fuels, in liquid alkanes and in food production.
Furfuryl Alcohol is also a very important intermediate in fine chemical synthesis and the polymer industry, and it is used as a chemical intermediate for the synthesis of lysine, vitamin C and levulinic acid and employed as a lubricant and as a dispersing agent.


Furfuryl alcohol reacts with formaldehyde and leads to the formation of resinous condensation products that are widely used in the production of thermosetting resins and are particularly resistant to chemicals and solvents.
Furfuryl alcohol was used in the synthesis of continuous titanium carbide nanofibers/nanoribbon.


Furfuryl alcohol is an efficient trapping agent for singlet oxygen determination in natural waters.
The mechanism of acid-catalyzed polycondensation of furfuryl alcohol has been investigated.
Furfuryl alcohol is used as a solvent and for the production of furan resins and, more recently, for chemical wood modification.


Furfuryl Alcohol is used primarily as a monomer for the synthesis of furan resins, which are in turn used to produce various adhesives, coatings and cement.
Furfuryl Alcohol is used manufacture of foundry resins, characterized by low viscosity, good mechanical strength at metal melting temperature, and low gas emission.


Furfuryl Alcohol is used production of corrosion-resistant resins with a very competitive price.
Furfuryl Alcohol is used production of abrasive wheels and adhesives based on urea-formaldehyde resin due to its wetting - dispersant properties.
Furfuryl Alcohol is used production of tetrahydrofurfuryl alcohol (THFA) as a solvent in the pharmaceutical industry.


-Furfuryl Alcohol may be used as an analytical reference standard for the determination of furfuryl alcohol in:
*Coffee samples by headspace solid-phase microextraction (HS-SPME) and gas chromatography (GC) coupled to flame ionization detector (FID) as well as mass spectrometry (MS).
*Jukro tea samples by simultaneous distillation-solvent extraction (SDE) and gas chromatography-mass spectrometry (GC-MS).
*Electronic-cigarette refill solutions by GC coupled to tandem mass spectrometry (MS/MS) operating on electron impact (EI) mode.
Coffee samples by HPLC coupled with diode array detector (DAD).


-Uses of Furfuryl Alcohol as rocket propellant (fuel component):
Furfuryl alcohol has been used in rocketry as a fuel that ignites spontaneously (on immediate and energetic contact) with white fuming nitric acid or red fuming nitric acid oxidizer.
The use of Hypergoric avoids the need for igniters.
In late 2012, Spectra, a concept liquid rocket engine that uses white fuming nitric acid as the oxidizer for furfuryl alcohol fuel, was statically tested by Copenhagen Suborbitals.


-Resins, composites:
The primary use of furfuryl alcohol is as a monomer for the synthesis of furan resins.
These polymers are used in thermoset polymer matrix composites, cements, adhesives, coatings and casting/foundry resins.
Polymerization involves an acid-catalyzed polycondensation, usually giving a black cross-linked product.


-Applications for furfuryl alcohol include:
*The production of corrosion-resistant fiber-reinforced plastics
*The manufacture of corrosion-resistant cement and mortars
*A viscosity reducer for epoxy resins
*Formulation of paint thinners and cleaning compounds
*A chemical building block for drug synthesis



PRODUCTION OF FURFURYL ALCOHOL:
Naturally occurring and readily replenishable agricultural residues like sugarcane bagasse (a byproduct of sugarcane harvesting), corn cobs, wood products or cereal byproducts such as the hulls of cotton seed, oats and rice make up a huge renewable feedstock for furfural production.
The incoming furfural is produced at the world’s largest furfural facility: CRC, based in the Dominican Republic.

The selective Cu-catalyzed hydrogenation of furfural is the sole industrial route for furfuryl alcohol production.
This process can be performed in gas or liquid phase.
The world’s biggest and most effective furfural hydrogenation plant, located near Antwerp (Belgium), is operated by IFC’s sister company TransFurans Chemicals, producing 40,000 MT annually.



REACTIONS OF FURFURYL ALCOHOL:
Furfuryl Alcohol undergoes many reactions including Diels–Alder additions to electrophilic alkenes and alkynes.
Hydroxymethylation gives 1,5-bis(hydroxymethyl)furan.
Hydrolysis gives levulinic acid.

Upon treatment with acids, heat and/or catalysts, furfuryl alcohol can be made to polymerize into a resin, poly(furfuryl alcohol).
Hydrogenation of furfuryl alcohol can proceed to give hydroxymethyl derivative of tetrahydrofuran and 1,5-pentanediol.

The etherification reaction of furfuryl alcohol with alkyl or aryl halide (e.g. benzyl chloride) in the liquid-liquid-liquid triphase system with the help of a phase transfer catalyst also reported.
In the Achmatowicz reaction, also known as the Achmatowicz rearrangement, furfuryl alcohol is converted to a dihydropyran.



SYNTHESIS OF FURFURYL ALCOHOL:
Furfuryl alcohol is manufactured industrially by hydrogenation of furfural, which is itself typically produced from waste bio-mass such as corncobs or sugar cane bagasse.
As such furfuryl alcohol may be considered a green chemical.
One-pot systems have been investigated to produce furfuryl alcohol directly from xylose using solid acid catalysts.



PHYSICAL and CHEMICAL PROPERTIES of FURFURYL ALCOHOL:
CAS Number: 98-00-0
Molecular Weight: 98.10
Beilstein: 106291
EC Number: 202-626-1
MDL number: MFCD00003252
Chemical formula: C5H6O2
Molar mass: 98.10 g/mol
Appearance: colorless liquid
Odor: burning odor
Density: 1.128 g/cm3
Melting point: −29 °C (−20 °F; 244 K)
Boiling point: 170 °C (338 °F; 443 K)
Solubility in water: miscible
Physical state: clear, liquid
Color: colorless
Odor: No data available
Melting point/freezing point:
Melting point/range: -29 °C - lit.
Initial boiling point and boiling range: 170 °C - lit.
Flammability (solid, gas): No data available

Upper/lower flammability or explosive limits:
Upper explosion limit: 16,3 %(V)
Lower explosion limit: 1,8 %(V)
Flash point: 65 °C - closed cup
Autoignition temperature: ca.490 °C
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,62 mPa.s at 25 °C
Water solubility: soluble
Partition coefficient: n-octanol/water:
log Pow: 0,3 at 25 °C - Bioaccumulation is not expected.
Vapor pressure: 0,53 hPa at 20 °C
Density: 1,135 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none

Other safety information:
Solubility in other solvents:
Alcohol - completely soluble
Ether - completely soluble
Chloroform - soluble
Dissociation constant: 9,55
Relative vapor density: 3,39 - (Air = 1.0)
Molecular Weight: 98.10 g/mol
XLogP3: 0.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 1
Exact Mass: 98.036779430 g/mol
Monoisotopic Mass: 98.036779430 g/mol
Topological Polar Surface Area: 33.4Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 54
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CAS: 98-00-0
Molecular Formula: C5H6O2
Molecular Weight (g/mol): 98.1
MDL Number: MFCD00003252
InChI Key: XPFVYQJUAUNWIW-UHFFFAOYSA-N
ChEBI: CHEBI:207496
IUPAC Name: furan-2-ylmethanol
SMILES: C1=COC(=C1)CO
Melting Point: -29°C
Color: Yellow
Density: 1.1300g/mL
Boiling Point: 170°C
Flash Point: 65°C
Infrared Spectrum: Authentic
Assay Percent Range: 97.5% min. (GC)
Refractive Index: 1.4850 to 1.488
Beilstein: 17, V,3, 338

Fieser: 01,408
Merck Index: 15, 4334
Specific Gravity: 1.13
Solubility Information: Solubility in water: miscible but unstable
Viscosity: 5 mPa.s (25°C)
Formula Weight: 98.1
Percent Purity: 98%
Physical Form: Liquid
Chemical Name or Material: Furfuryl alcohol
CAS number: 98-00-0
EC index number: 603-018-00-2
EC number: 202-626-1
Hill Formula: C₅H₆O₂
Molar Mass: 98.1 g/mol
HS Code: 2932 13 00
Boiling point: 170 - 171 °C (1013 mbar)
Density: 1.132 g/cm3 (20 °C)
Explosion limit: 1.8 - 16.3 %(V)
Flash point: 65 °C
Ignition temperature: 390 °C
Melting Point: -29 °C
pH value: 6 (300 g/l, H₂O, 20 °C)
Vapor pressure: 53 Pa (20 °C)

Physical description: Colorless to amber liquid with a faint, burning odor.
Boiling point: 338°F
Molecular weight: 98.1
Freezing point/melting point: -24°F
Vapor pressure: 0.6 mmHg at 77°F
Flash point: 167°F
Vapor density: 3.4
Specific gravity: 1.13
Lower explosive limit (LEL): 1.8%
Upper explosive limit (UEL): 16.3%
NFPA health rating: 3
NFPA fire rating: 2
NFPA reactivity rating: 1
Furfuryl Alcohol: C4H3OCH2OH
Molecular Weight: 98.10 g/mole
Boiling Point (760 mm Hg): 169.5 oC
Freezing Point: -14.6 oC
Specific Gravity 25oC/25oC: 1.1351
Refractive Index 20oC: 1.4870
Viscosity at 25oC: 4.62 cPs
Flash Point (closed cup): 65 oC
Ignition Temperature: 391 oC
Solubility in Water at 20 oC: ∞



FIRST AID MEASURES of FURFURYL ALCOHOL:
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of FURFURYL ALCOHOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of FURFURYL ALCOHOL:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of FURFURYL ALCOHOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 240 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A-(P2)
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of FURFURYL ALCOHOL:
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Advice on protection against fire and explosion:
Take precautionary measures against static discharge.
*Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Air sensitive.



STABILITY and REACTIVITY of FURFURYL ALCOHOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
2-(Hydroxymethyl)furan
(Furan-2-yl)methanol
Furan-2-ylmethanol
Furfuryl alcohol
2-Furanmethanol
2-Furancarbinol
2-(Hydroxymethyl)furan
FURFURYL ALCOHOL
98-00-0
2-Furanmethanol
2-Furylmethanol
furan-2-ylmethanol
2-Furancarbinol
Furfural alcohol
2-Furylcarbinol
2-Furanylmethanol
Furfuranol
2-Furfuryl alcohol
Furfurylalcohol
Furfuralcohol
5-Hydroxymethylfuran
2-(Hydroxymethyl)furan
Furyl alcohol
2-Hydroxymethylfuran
Furylcarbinol
alpha-Furylcarbinol
Furan-2-yl-methanol
2-Furfurylalkohol
Furfurylcarb
(2-furyl)methanol
Methanol, (2-furyl)-
2-hydroxymethylfurane
2-Furane-methanol
Furanmethanol
Furylcarbinol (VAN)
NCI-C56224
25212-86-6
2-furanemethanol
FEMA No. 2491
Furan-2-methanol
NSC 8843
(furan-2-yl)methanol
CCRIS 2922
HSDB 711
DTXSID2025347
CHEBI:207496
EINECS 202-626-1
Furfurylalcohol-d2
Qo furfuryl alcohol
UNII-D582054MUH
BRN 0106291
.alpha.-Furylcarbinol
alpha-Furfuryl alcohol
AI3-01171
D582054MUH
NSC-8843
.alpha.-Furfuryl alcohol
DTXCID105347
EC 202-626-1
5-17-03-00338 (Beilstein Handbook Reference)
Furfuryl alcohol, 98%
(2-FURYL)-METHANOL (FURFURYLALCOHOL)
FURFURYL ALCOHOL (IARC)
FURFURYL ALCOHOL [IARC]
2-Furfurylalkohol
CAS-98-00-0
FURFURYLALCOHOLRESIN
UN2874
2-Hydroxymethylfuran
2-Furylmethanol
2-Furfurylalcohol
furylmethanol
2-Furfurylalcohol
FU2
alpha -Furylcarbinol
MFCD00003252
PFFA
(2-furyl)-Methanol
Furfuryl alcohol [UN2874]
2-Hydroxymethyl-Furan
alpha -Furfuryl alcohol
Furfuryl alcohol, 8CI
2- FURANCARBINOL
2- FURANYLMETHANOL
Epitope ID:136037
furfuryl alcohol (furfurol)
WLN: T5OJ B1Q
CHEM-REZ 200
2-Furane-methanol (furfurol)
FURFURYL ALCOHOL [MI]
FURFURYL ALCOHOL [FCC]
CHEMBL308187
FURFURYL ALCOHOL [FHFI]
FURFURYL ALCOHOL [HSDB]
CHEBI:53371
FEMA 2491
Furfuryl alcohol, >=97%, FG
NSC8843
2-Furanmethanol (furfuryl alcohol)
2-Furylmethanol (ACD/Name 4.0)
STR01021
Tox21_202102
Tox21_303093
Furfuryl alcohol, analytical standard
AKOS000119178
AM81811
UN 2874
Furfuryl alcohol [UN2874]
Furfuryl alcohol, natural, >=95%, FG
NCGC00249166-01
NCGC00256987-01
NCGC00259651-01
93793-62-5
F0076
FT-0626576
FT-0668910
EN300-19106
C20441
Q27335
A845784
J-521401
F0001-2310
Z104472794
InChI=1/C5H6O2/c6-4-5-2-1-3-7-5/h1-3,6H,4H
2- FURANCARBINOL
FURFURALCOHOL
alpha-FURYLCARBINOL
2-HYDROXYMETHYLFURAN


GALACTOMANNAN POLYSACCHARIDE
Galactomannan polysaccharide is polysaccharide derivative.
Galactomannan polysaccharide increases or decreases the viscosity (toughness) of cosmetic products.
Galactomannan is one of the polysaccharides that has been studied and proven to have antioxidant and antibacterial activity.


CAS Number: 9000-30-0
EC Number: 232-536-8


Galactomannan polysaccharides are versatile macromolecules with broad industrial potential.
The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied.
The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans.


The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial.
Sugar palm fruit produced by palm trees (Arenga pinnata) is a fruit that contains galactomannan polysaccharide compounds.
Galactomannan contained in sugar palm fruit has antioxidant and antibacterial activity.


Sugar palm fruit is one of the natural ingredients that has not been studied for Galactomannan polysaccharide's potential as a compound that contains antioxidant activity.
Sugar palm fruit is mostly produced in the highlands of Toba, North Sumatra.
In general, sugar palm fruit in the Toba area is only used as food.


Sugar palm fruit contains 90.23-92.28% water, 1.42-3.11% protein, 3.42-4.09% carbohydrates, 1.59-2.50% fiber, 0.27-0.67 % fat, and 0.12-0.30% ash.
Carbohydrates in sugar palm fruit consist of Galactomannan polysaccharide with a mannose-to-galactose ratio ranging from 2:1 to 5:1.
Research conducted reported that Galactomannan polysaccharide has high antioxidant activity.


The antioxidant activity of Galactomannan polysaccharide is due to the presence of bioactive compounds which are conjugated with these galactomannans.
In addition to having antioxidant activity, Galactomannan polysaccharide from Prosopis spp can also be used for the formation of galactomannan/Zn (OH)2-ZnO composites so that they have antibacterial activity, as reported by.


The increase in antioxidant and antibacterial activity of the Galactomannan polysaccharide compound allows it to be carried out by the fermentation method.
Several researchers have reported that Galactomannan polysaccharides isolated from various plant species have antioxidant and antibacterial activities.


This proves that some bioactive compounds are conjugated with Galactomannan polysaccharide. ,
When fermentation is carried out on plants containing galactomannan polysaccharides, the microorganisms used as fermentation starters will produce enzymes that can hydrolyze bonds in polysaccharide compounds, so that bioactive compounds conjugated with polysaccharides can be released and sugars in polysaccharides can be utilized for cellular metabolic processes.


Bioactive compounds that have been released from polysaccharides have higher antioxidant and antibacterial activity.
Sugar palm fruit which is known to contain galactomannan polysaccharides and has antioxidant and antibacterial activity, has the potential to increase its antioxidant and antibacterial activity through fermentation methods which have not been studied much.
Therefore, submerged fermentation (SmF), solid state fermentation (SSF), and liquid fermentation methods can be recommended.


The optimum water content for the SSF method is about 75%, therefore the SSF method on sugar palm fruit is possible because the water content in sugar palm fruit is sufficient, which is about 91.8% in 100 grams of sugar palm fruit.
The SmF and liquid fermentation methods have several advantages, such as easy control of conditions, increased microbial contact with the substrate, faster and similar fermentation, and easier purification of the final product.


However, this method also has several drawbacks, for instance, it produces a lot of waste, requires high water requirements, and commands higher costs.
The advantages of the SSF method include lower costs, less water requirements, produce less waste and require lower energy, while the drawbacks of the SSF method are that it is prone to contamination.
Galactomannan polysaccharide fermentation can be carried out by microorganisms from the fungi and bacteria groups.


The type of fungus that can be used is Rhizopus oryzae and the type of bacteria is from the lactic acid bacteria group.
Galactomannan polysaccharide is a heteroglycan consisting of a mannan backbone with galactose side groups.
Galactomannan polysaccharide is a natural product found in Astragalus lehmannianus, Umbilicaria esculenta, and other organisms with data available.


Galactomannans are polysaccharides consisting of a mannose backbone with galactose side groups, more specifically, a (1-4)-linked beta-D-mannopyranose backbone with branchpoints from their 6-positions linked to alpha-D-galactose, (i.e. 1-6-linked alpha-D-galactopyranose).


In order of increasing number of mannose-to-galactose ratio:
fenugreek gum, mannose:galactose ~1:1
guar gum, mannose:galactose ~2:1
tara gum, mannose:galactose ~3:1
locust bean gum or carob gum, mannose:galactose ~4:1
cassia gum, mannose:galactose ~5:1


Galactomannans are often used in food products to increase the viscosity of the water phase.
Guar gum has been used to add viscosity to artificial tears, but is not as stable as carboxymethylcellulose.



USES and APPLICATIONS of GALACTOMANNAN POLYSACCHARIDE:
Galactomannan polysaccharide has a coating action on the skin that allows for moisture retention often used as a thickener and emulsifier in cosmetic formulations, guar gum is a polysaccharide found in the seeds of the guar plant.
Galactomannan polysaccharide is the nutrient material required by the developing plant embryo during germination.


When the endosperm, once separated from the hull and embryo, is ground to a powder form, Galactomannan polysaccharide is marketed as guar gum.
A 1% solution has a viscosity range of 2,000–3,500 cp at 25°c. Galactomannan polysaccharide is a versatile thickener and stabilizer used in ice cream, baked goods, sauces, and beverages at use levels ranging from 0.1 to 1.0%.
Galactomannan polysaccharide is used low calorie, soluble dietery fiber.


Galactomannan polysaccharide is used as a food additive, emulsifying stabilizer, thickener and gelling agent.
Galactomannan polysaccharide is used In paper sizing; as a protective colloid, stabilizer, thickening and film-forming agent for cheese, salad dressings, ice cream, and soups.


Galactomannan polysaccharide is used as a binding and disintegrating agent in tablet formulations in pharmaceutical jelly formulations, suspensions, emulsions, lotions, creams, and toothpaste in the mining industry as a flocculant, as a filtering agent in water treatment as a coagulant aid.


The most important property of Galactomannan polysaccharide is the ability to hydrate rapidly in cold water to attain a very high viscosity.
In addition to the food industry, Galactomannan polysaccharide is used in the mining, paper, textile, ceramic, paint, cosmetic, pharmaceutical, explosive, and other industries.


-Food grade:
*frozen food:
stop ice dreg from forming and increase the frozen stability.
-Pet goods:
increase oily slippery feeling and keep the humidity.


-Baking food:
keep the humidity and improve the texture.
-Drink:
improve taste and stabilize particle suspension.


-Salad dressing:
thickener, alternative oil.
-Cheese and cream:
improve the texture.


-Cooked meat food:
maintain water, increase oily slippery feeling.
-Vegetarian food:
alternative fat ingredients,keep moisture.


-Industrial grade:
*oil well fracturing and other drilling industries.
*Carpets, spin printing and dyeing, leather chemical industry. Building materials, cement, paint, tiles.
*Paper industry, pharmaceutical industry.
*Shampoo, detergent, skin care products, cosmetics.
*Viscera.
*Latex paint, exterior latex paint.


-Cosmetic Uses:
*binding agents
*emulsion stabilisers
*film formers
*surfactant - emulsifying
*viscosity controlling agents


-Pharmaceutical Applications of Galactomannan polysaccharide:
Galactomannan polysaccharide is a galactomannan, commonly used in cosmetics, food products, and pharmaceutical formulations.
Galactomannan polysaccharide has also been investigated in the preparation of sustained-release matrix tablets in the place of cellulose derivatives such as methylcellulose.
In pharmaceuticals, Galactomannan polysaccharide is used in solid-dosage forms as a binder and disintegrant; in oral and topical products as a suspending, thickening, and stabilizing agent; and also as a controlled-release carrier.
Galactomannan polysaccharide has also been examined for use in colonic drug delivery.
Therapeutically, Galactomannan polysaccharide has been used as part of the diet of patients with diabetes mellitus.


-Food use of Galactomannan polysaccharide:
Galactomannan polysaccharides are used in foods as stabilisers.
Galactomannan polysaccharide and locust bean gum (LBG) are commonly used in ice cream to improve texture and reduce ice cream meltdown.
LBG is also used extensively in cream cheese fruit preparations and salad dressings.
Galactomannan polysaccharide is seeing growing acceptability as a food ingredient but is still used to a much lesser extent than guar or LBG.
Galactomannan polysaccharide has the highest usage in foods, largely due to its low and stable price.


-Clinical use of Galactomannan polysaccharide
Galactomannan polysaccharide is a component of the cell wall of the mold Aspergillus and is released during growth.
Detection of Galactomannan polysaccharide in blood is used to diagnose invasive aspergillosis infections in humans.
This is performed with monoclonal antibodies in a double-sandwich ELISA; this assay from Bio-Rad Laboratories was approved by the FDA in 2003 and is of moderate accuracy.
The assay is most useful in patients who have had hemopoetic cell transplants (stem cell transplants).



CHEMICAL PROPERTIES OFGALACTOMANNAN POLYSACCHARIDE:
*White to light yellowish.
*Free flowing powder.
*Close to odorless.
*Form viscous liquid after dispersing in hot or cold water.
*The viscosity of 1% aqueous solution is about 4~5Pa which is the highest viscosity in natural rubber.
*After adding small amount of sodium tetraborate Galactomannan polysaccharide changes to gel.
*After dispersing in cold water for about 2h Galactomannan polysaccharide shows strong viscosity and the viscosity gradually increases reached the highest point after 24h.
*Galactomannan polysaccharide's viscosity is 5 to 8 times than that of starch and quickly reaches the highest point under heat.
*The aqueous solution is neutral.
*The viscosity is highest with pH between 6 and 8 and substantially decreases when pH is above10.
*And viscosity decreases sharply along with pH value dropping when pH value is 6.0 to 3.5.
The viscosity below 3.5 increases again.
*Yellowish-white free-flowing powder.
*Completely soluble in hot or cold water.
*Practically insoluble in oils, greases, hydrocarbons, ketones, esters.
*Water solutions are tasteless, odorless, nontoxic.
*Has 5-8 times the thickening power of starch.
*Reduces the friction drag of water on metals.



FUNCTIONS OF GALACTOMANNAN POLYSACCHARIDE:
*Fixing agent:
Galactomannan polysaccharide allows the cohesion of different cosmetic ingredients

*Emulsifying agent:
Galactomannan polysaccharide promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)

*Emulsion Stabilizer:
Galactomannan polysaccharide aids the emulsification process and improves emulsion stability and shelf life

*Film forming agent:
Galactomannan polysaccharide produces a continuous film on the skin, hair or nails

*Viscosity control agent:
Galactomannan polysaccharide increases or decreases the viscosity of cosmetics



FUNCTIONS OF GALACTOMANNAN POLYSACCHARIDE IN COSMETIC PRODUCTS:
Function(s) of this ingredient in cosmetic products:
*BINDING:
Galactomannan polysaccharide ensures the cohesion of powdered and powdered products

*EMULSION STABILIZING:
Galactomannan polysaccharide supports emulsification and improves product stability

*FILM FORMING:
Galactomannan polysaccharide forms a film on skin, hair or nails

*TENSID (EMULSIFYING) - EMULGATOR:
Galactomannan polysaccharide allows the formation of finely divided mixtures of oil and water (emulsions)



ACTION IN COSMETICS OF GALACTOMANNAN POLYSACCHARIDE:
*Binders:
Galactomannan polysaccharide is a substance that binds cosmetic ingredients.
Galactomannan polysaccharide is used as an emulsifier - Galactomannan polysaccharide combines the water phase and the oil phase.
The emulsifier molecules line up at the interface, partially dissolving in one phase and partially in the other.
Thanks to this, they stabilize the interface between the phases and hence the cream, lotion or other cosmetic does not stratify.
Galactomannan polysaccharide regulates the viscosity of the cosmetic - Galactomannan polysaccharide increases or decreases it.



COMPONENT TYPE OF GALACTOMANNAN POLYSACCHARIDE:
*Synthetic substance



FUNCTION IN COSMETICS OF GALACTOMANNAN POLYSACCHARIDE:
*Emulsifier, emulsifier
*Binder
*Viscosity regulator
*Film-forming substance
*Excipient



PHYSICAL and CHEMICAL PROPERTIES of GALACTOMANNAN POLYSACCHARIDE:
Appearance Form: solid
Odor: No data available
Odor Threshold: No data available
pH: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available
Relative density: No data available
Water solubility: No data available

Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Appearance: White to off-white powder
Purity: ≥75% (Mannose + Galactose)
Identity (1H NMR): Proton NMR
Storage and Stability: Store at 4°C.



FIRST AID MEASURES of GALACTOMANNAN POLYSACCHARIDE:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GALACTOMANNAN POLYSACCHARIDE:
-Environmental precautions:
No special environmental precautions required.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GALACTOMANNAN POLYSACCHARIDE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Special hazards arising from the substance or mixture:
Nature of decomposition products not known.
-Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of GALACTOMANNAN POLYSACCHARIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Appropriate engineering controls:
General industrial hygiene practice.
-Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
-Control of environmental exposure:
No special environmental precautions required.



HANDLING and STORAGE of GALACTOMANNAN POLYSACCHARIDE:
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature 2 - 8 °C



STABILITY and REACTIVITY of GALACTOMANNAN POLYSACCHARIDE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
Galactomannan
Galactomannoglycan
CAROB GALACTOMANNAN
11078-30-1
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol
C00883
AC1L975N
D-Galacto-D-mannane
SCHEMBL19799345
CHEBI:27680
ZINC8216558
W-200825
6-O-alpha-D-Galactopyranosyl-4-O-beta-D-mannopyranosyl-beta-D-mannopyranose
WURCS=2.0/2,3,2/[a1122h-1b_1-5][a2112h-1a_1-5]/1-1-2/a4-b1_a6-c1
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]methoxy]tetrahydropyran-3,4,5-triol
Guar GuM Hydrolyzed
Guar Gum - HPMC
1212a
a-20d
burtonitev7e
burtonitev-7-e
cyamopsisgum
dealcatp1

GALACTOMANNAN POLYSACCHARIDE (GUAR GUM)
Galactomannan polysaccharide (guar gum), also called guaran, is a galactomannan polysaccharide extracted from guar beans that has thickening and stabilizing properties useful in food, feed, and industrial applications.
Galactomannan polysaccharide (guar gum) seeds are mechanically dehusked, hydrated, milled and screened according to application.
Galactomannan polysaccharide (guar gum) is typically produced as a free-flowing, off-white powder.


CAS Number: 9000-30-0
EC Number: 232-536-8
MDL Number: MFCD00131250
Chem/IUPAC Name: Cyamopsis Tetragonoloba Gum is a resinous material derived from the ground endosperm of the Guar, Cyamopsis tetragonoloba L., Leguminosae


Chemically, Galactomannan polysaccharide (guar gum) is an exo-polysaccharide composed of the sugars galactose and mannose.
The backbone is a linear chain of β 1,4-linked mannose residues to which galactose residues are 1,6-linked at every second mannose, forming short side-branches.
Galactomannan polysaccharide (guar gum) has the ability to withstand temperatures of 80 °C (176 °F) for five minutes.


Galactomannan polysaccharide (guar gum) belongs to the pea family that is majorly produced in India and Pakistan and the minor producers being China, Africa, the USA, Australia, and a few more.
Galactomannan polysaccharide (guar gum) powder exporters claim it to have almost eight times better than corn starch or similar food agents.


Galactomannan polysaccharide (guar gum) has the property of getting dispersed into the water while hydrating and swelling quickly to form a viscous solution.
The viscosity depends on factors like temperature, pH value, agitation rate, size of the particle, and concentration.
Galactomannan polysaccharide (guar gum) is a resinous material derived from the groundendosperm of Cyanopsis tetragonoloba.


Derivatives of Galactomannan polysaccharide (guar gum) that also may be used in cosmetics and personal care products include Hydroxypropyl Guar, Guar Hydroxpropyltrimonium Chloride and Hydroxypropyl Guar Hydroxypropyltrimonium Chloride.
Among these guar ingredients, Guar Hydroxypropyltrimonium Chloride is most frequently used in cosmetic products.


Galactomannan polysaccharide (guar gum) is the ground endosperm of the seed of the plant Cyamopsis tetragonolobus.
Galactomannan polysaccharide (guar gum) has been widely cultivated for centuries in India, for both animal and human consumption, and today India meets nearly 85% of the worldwide demand for Galactomannan polysaccharide (guar gum).


Galactomannan polysaccharide (guar gum) (also called Guar Gum) is a resinous material made from the guar bean.
Galactomannan polysaccharide (guar gum) is a type of polysaccharide called galactomannan made from legume plants that consists of a polymannose backbone to which galactose groups are bound.


Guar is primarily grown in the states of Rajasthan, Haryana and Gujarat and to a very small extent in the states of Uttar Pradesh and Madhya Pradesh.
However due to the recent rise in demand for Galactomannan polysaccharide (guar gum), other Indian states such as Maharashtra and Andhra Pradesh have also started experimenting with Guar cultivation.
This plant is cultivated in Pakistan and the United States.


Galactomannan polysaccharide (guar gum) is a plant-derived (coming from the seeds of Cyamopsis Tetragonoloba, aka Guar) big, branched sugar molecule that is used as a gelling agent.
Galactomannan polysaccharide (guar gum) gets its name from a Sanskrit phrase that means “cow food.”
The molecular weight of Galactomannan polysaccharide (guar gum) is estimated at between 200,000 and 250,000 Dalton.


Galactomannan polysaccharide (guar gum) is obtained by grinding the endosperm of a leguminous plant (Cyamopsis tetragonolobus) from India and Pakistan.
Galactomannan polysaccharide (guar gum) Market report highlights significant growth opportunities and challenges of Top Key Players along with revenue and CAGR status.
Guar seeds are about 3 mm to 5 mm in diameter and are dicotyledonous i.e. they have two endosperm halves.
Also known as Guar Splits, the endosperm halves are separated from the germ and hull using a combination of thermal and mechanical processes.


Guar Splits are then milled to produce Galactomannan polysaccharide (guar gum) powder.
Galactomannan polysaccharide (guar gum) is a creamish-white bland-tasting powder that is almost odourless.
Galactomannan polysaccharide (guar gum) disperses readily in hot or cold water to form a viscous pseudoplastic sol.


Galactomannan polysaccharide (guar gum) is a polysaccharide.
The galactomannan molecule is composed of a long straight chain of D-mannopyranose units with single membered side chains of D-galactopyranose units.
The Guar crop is sown after the first rains in June / July and is harvested after approximately 3 months.


Guar is a hardy, drought-resistant plant and requires 3 to 4 moderate rains at intervals of 15 to 20 days.
The Guar plant sprouts bean-like pods that are 5-10 cms long and contains 8-10 seeds.
Galactomannan polysaccharide (guar gum) has excellent properties such as gelling, thickening, emulsification and stable dispersion


Galactomannan polysaccharide (guar gum), also called guaran, is a substance made from guar beans which has thickening and stabilizing properties useful in various industries, traditionally the food industry and, increasingly, the hydraulic fracturing industry.
Galactomannan polysaccharide (guar gum) or cluster bean, with the botanical name Cyamopsis tetragonoloba, is an annual legume and the source of guar gum.


Galactomannan polysaccharide (guar gum) is also known as gavar, gawar, or guvar bean.
The origin of Cyamopsis tetragonoloba is unknown, since Galactomannan polysaccharide (guar gum) has never been found in the wild.
Galactomannan polysaccharide (guar gum), also known as Goma Guar, Gauran Goma Guar, and Gomme Guar, is a natural fibre obtained from the Indian Cyamopsis tetragonolobus plant, or Guar Plant.


Galactomannan polysaccharide (guar gum) consists of the endosperm of the seeds of the legume native to India.
The seeds are ground into a powder, of which Galactomannan polysaccharide (guar gum) is composed.
Galactomannan polysaccharide (guar gum) is a natural polysaccharide extracted from the seeds of the plant Cyamopsis tetragonolobus and consists mainly of galactose and mannan.


Guar bushes thrive in India, Pakistan, South Africa, Australia and the United States.
Galactomannan polysaccharide (guar gum) is found in powder form, it is odorless and tasteless, and water soluble in hot and cold water.
Guar plant is an annual crop and accommodative in growth even in dry regions.


Not much fertile soil is required for cultivation as they can grow in sandy soils.
Being a legume, it releases nitrogen into the soil making it more fertile giving it a great place in a crop rotation.
Galactomannan polysaccharide (guar gum) is made by grinding the endosperm of the leguminous plant Guar bean (Cyamopsis tetragonolobus).


Galactomannan polysaccharide (guar gum) is a macromolecular natural hydrophilic colloid, mainly composed of galactose and mannose.
Galactomannan polysaccharide (guar gum) belongs to natural galactomannan and is almost tasteless.
Galactomannan polysaccharide (guar gum) is well-known as an economical thickening agent as it has almost eight times the water-thickening potency of cornstarch, and only a very small quantity is needed for producing sufficient viscosity.


Galactomannan polysaccharide (guar gum) also retards ice crystal growth nonspecifically by slowing mass transfer across the solid/liquid interface.
Galactomannan polysaccharide (guar gum) is made from the seed tissue of the Guar plant’s beans, commonly known as Cluster Beans or Siam Beans.
Galactomannan polysaccharide (guar gum) is a water-soluble powder that is soft, fine, and off-white.


Galactomannan polysaccharides, including Galactomannan polysaccharide (guar gum), are derived from plants of the bean (also called the Legume family).
In most of the places where drought condition is there, guar plants can grow easily.
Galactomannan polysaccharide (guar gum) is most commonly grown in India and Pakistan.


Galactomannan polysaccharide (guar gum) is a fibre from the seed of the guar plant.
Galactomannan polysaccharide (guar gum) is assumed to have developed from the African species Cyamopsis senegalensis.
Galactomannan polysaccharide (guar gum) was further domesticated in South Asia, where it has been cultivated for centuries.


Guar grows well in semiarid areas, but frequent rainfall is necessary.
Galactomannan polysaccharide (guar gum) can be dispersed in hot or cold water to form a viscous liquid.
The viscosity of 1% aqueous solution is about 4-5pa-s, which is higher in natural rubber.


The addition of a small amount of sodium tetraborate was converted to a gel.
The average molecular weight is about 25,000 Daltons.
This gives a Galactomannan polysaccharide (guar gum) that still assays and functions as a soluble dietary fiber.


Galactomannan polysaccharide (guar gum) as sold commercially is completely soluble, acid and heat stable, unaffected by ions, and will not gel at high concentrations.
These plants make galactomannan polysaccharides as a source of energy to support the growth of the embryo within the seed.
Galactomannan polysaccharide (guar gum) is from certified organic agriculture, a natural clear thickener for dye pastes and paints.


Galactomannan polysaccharide (guar gum) is a natural ingredient obtained by grinding the seeds of Cyamopsis tetragonolobus.
Galactomannan polysaccharide (guar gum) can be dissolved in cold water or hot water to form a sol, and the pH of the natural solution is between 6-8.
Galactomannan polysaccharide (guar gum) is a thickening agent for water-based formulation.


Galactomannan polysaccharide (guar gum) is a white or slightly yellowish brown powder, some granular or flat, odorless.
Galactomannan polysaccharide (guar gum) has a multitude of different applications in food products, industrial products, and extractive industry.
Partially hydrolyzed Galactomannan polysaccharide (guar gum) is produced by the partial enzymatic hydrolysis of guaran, the galactomannan of the endosperm of guar seeds (guar gum).


Galactomannan polysaccharide (guar gum) is a neutral polysaccharide consisting of a mannose backbone chain with single galactose side units occurring on almost two out of every three mannose units.
Galactomannan polysaccharide (guar gum) is a fine, white, and cream-coloured powder with zero chemical additives.


Galactomannan polysaccharide (guar gum) has almost 8 times the water-thickening potency of similar products like corn starch.
Galactomannan polysaccharide (guar gum) can hinder ice crystal growth and shows good stability during freeze-thaw cycles.
The guar seeds are dehusked, milled and screened to obtain the guar gum.


Galactomannan polysaccharide (guar gum) is typically produced as a free-flowing, off-white powder.
Galactomannan polysaccharide (guar gum) is classed as a galactomannan.
The seeds of the guar bean contain a large endosperm.
This endosperm consists of a large polysaccharide of galactose and mannose.


This polymer is water-soluble and exhibits a viscosifying effect in water.
Galactomannan polysaccharide (guar gum) consists primarily of the ground endosperm of guar beans.
The seeds are de-husked, milled and screened to obtain the guar gum.
Galactomannan polysaccharide (guar gum) is highly soluble in water and actually naturally binds with water molecules.



USES and APPLICATIONS of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Reputed manufacturers and exporters use an advanced process to de-husk, screen mill, and further pulverized to obtain refined Galactomannan polysaccharide (guar gum) powder that is used in diverse industries.
Galactomannan polysaccharide (guar gum) is extracted from the guar bean and is extensively used as a thickening agent and emulsifier in food industries.


Galactomannan polysaccharide (guar gum) manufacturers also cater to a plethora of industries like the oil drilling, paper manufacturing, construction, mining, textiles, printing, cosmetics, pharmaceuticals, beverage, food industry, pet foods and much more.
Galactomannan polysaccharide (guar gum) is added in sauces, jams, dairy products, and baking mixes to give a good thickening to a product so that a nice consistency is achieved.


Industrial products which make massive use of Galactomannan polysaccharide (guar gum) include body lotions, instant soups, yogurts, coconut, bottled soya and almond milk.
Galactomannan polysaccharide (guar gum) has immense properties of stabilization, thickening, texturization, and emulsification.
In cosmetics, Galactomannan polysaccharide (guar gum) is a thickening agent (used hot or cold).


Galactomannan polysaccharide (guar gum) provides a smooth, silky finish to your preparations, making it perfect for creams, lotions, and body milks.
Galactomannan polysaccharide (guar gum) is ideal for gelling water and aqueous solutions (hydrosols etc) hence its use in manufactured gel toothpastes and hair gels.
Hydroxypropyl Guar is also used in artificial tear solutions.


Plant-derived thickening agent, Galactomannan polysaccharide (guar gum), is often used in products that are attempting to be (or are) mostly natural.
Galactomannan polysaccharide (guar gum) is regarded for its use as a gelling agent and gives gels and emulsions their consistencies.
Frequent consumption of Galactomannan polysaccharide (guar gum) has also been found to help lower triglycerides and blood cholesterol levels and balance glucose levels.


Galactomannan polysaccharide (guar gum) is a resin-like material derived from the ground endosperm of the Guar, Cyamopsis tetragonoloba L., Leguminosae.
Galactomannan polysaccharide (guar gum) is used as an emulsion stabilizer, viscosity controller and film forming agent.
Clinical studies have shown that Galactomannan polysaccharide (guar gum) acts as a probiotic and due to its ability to absorb the right amount of fluids, reduces the symptoms of constipation, diarrhea and abdominal pain.


Galactomannan polysaccharide (guar gum)'s use increases the feeling of hunger satiety, and contributes to the reduction of food consumption and weight loss.
In cheeses Galactomannan polysaccharide (guar gum) serves to improve their texture.
In pre-fried foods reduce oil intake.


But Galactomannan polysaccharide (guar gum) seems to have health benefits.
Galactomannan polysaccharide (guar gum) powder is a polysaccharide that is predominantly made up of the crushed endosperm of guar beans and is used as a binder, thickener, and stabiliser in cosmetic compositions.


Galactomannan polysaccharide (guar gum) can be used in products as the only gelling/thickening agent.
Galactomannan polysaccharide (guar gum) is a good source of fiber for people who can not get the necessary daily amount through their diet, or for some reason have excluded them.
Galactomannan polysaccharide (guar gum) normalizes bowel function.


Galactomannan polysaccharide (guar gum) has a beneficial effect in cases of irritable bowel syndrome.
In addition, Galactomannan polysaccharide (guar gum) is a great moisturizer and easily counteracts the loss of moisture.
Galactomannan polysaccharide (guar gum) can be used in cold liquids.


Galactomannan polysaccharide (guar gum) can be used in products as the only gelling/thickening agent.
Galactomannan polysaccharide (guar gum) is used in non-oxidative, herbal Hair Colorants to give the product the desired consistency for application.
Galactomannan polysaccharide (guar gum) can also be found in bath products, hair care products, shaving preparations and skin care products.


Commercial Galactomannan polysaccharide (guar gum) is approximately 75% dietary fiber and has minimal effect on taste and texture in food and beverage items.
As a food additive, Galactomannan polysaccharide (guar gum) is used mainly as a thickening agent, and as a homogenizer and stabilizer of mixtures in sweets, ice cream jellies, etc.


In ice cream Galactomannan polysaccharide (guar gum) homogenizes the mixture and reduces ice crystals.
In baked goods it works as an improver of the texture of the dough.
Galactomannan polysaccharide (guar gum) is fully fermentable in the large bowel, with a high rate of volatile fatty acid formation.
The pH of the feces is lowered along with an increase in fecal bulk that mainly consists of bacterial cell mass and water.


Clinical studies have demonstrated a prebiotic effect of Galactomannan polysaccharide (guar gum).
Galactomannan polysaccharide (guar gum) is mainly used as a thickening agent and a stabilizer.
Galactomannan polysaccharide (guar gum) is used as a stabilizer and a viscosity modifier in cosmetic emulsions.


Galactomannan polysaccharide (guar gum) is a natural polysaccharide used mainly as a thickener, and as a food homogenizer.
Ever since the 1950s, the guar plant has been the source of the Galactomannan polysaccharide (guar gum) additive the food industry uses to thicken foods or keep various ingredients smoothly mixed together.


It’s in everything from frozen pizza to ice cream, egg white substitutes, and baked goods.
Studies have shown that Galactomannan polysaccharide (guar gum) can be used to maintain regularity.
Galactomannan polysaccharide (guar gum) is used in foods for particulate suspension, emulsification, antistaling, ice crystal control, and reduced fat baked goods.


Galactomannan polysaccharide (guar gum) may be used in bath products, hair conditioners, hair dyes, other hair care products and skin care products.
Galactomannan polysaccharide (guar gum) powder is certified organic and is used as a binder, thickener, and volume enhancer in food preparations.
In other words, Galactomannan polysaccharide (guar gum) shows good stability during freeze-thaw cycles, making it a popular ingredient in ice cream.


Galactomannan polysaccharide (guar gum) is also popularly used in gluten-free recipes and gluten-free products.
Galactomannan polysaccharide (guar gum) and the other guar derivatives may also be used in bath products, hair care products, shaving preparations and skin care products.
In addition to being used in cosmetics and personal care products, Galactomannan polysaccharide (guar gum) is commonly used as a thickener in foods such as salad dressings, ice cream and soups.


-Domestic use of Galactomannan polysaccharide (guar gum):
*Vegetable:
Galactomannan polysaccharide (guar gum)leaves can be used like spinach, and the pods are prepared like salad or vegetables.
Galactomannan polysaccharide (guar gum)'s beans are nutritious, but guar protein is not usable by humans unless toasted to destroy the trypsin inhibitor.


-Industrial applications of Galactomannan polysaccharide (guar gum):
*Textile industry – sizing, finishing and printing
*Paper industry – improved sheet formation, folding and denser surface for printing
*Explosives industry – as waterproofing agent mixed with ammonium nitrate, nitroglycerin, etc.
*Pharmaceutical industry – as binder or as disintegrator in tablets; main ingredient in some bulk-forming laxatives
*Cosmetics and toiletries industries – thickener in toothpastes, conditioner in shampoos (usually in a chemically modified version)
*Hydraulic fracturing Shale oil and gas extraction industries consumes about 90% of Galactomannan polysaccharide (guar gum) produced from India and Pakistan.


-Food:
In several food and beverages Galactomannan polysaccharide (guar gum) is used as additive to change its viscosity or as fiber source
-Forage:
Galactomannan polysaccharide (guar gum) plants can be used as cattle feed, but due to hydrocyanic acid in its beans, only mature beans can be used.
-Green manure:
Galactomannan polysaccharide (guar gum) plantings increase the yield of subsequent crops as this legume conserves soil nutrient content.



BENEFITS OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
*Lowering blood Glucose
*Lowering insulin levels



PROPERTIES OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
*Galactomannan polysaccharide (guar gum) has reasonably more thickening property as compared to corn starch.
*Holds back the growth of ice crystal
*Guar is draught resistant plant
*Galactomannan polysaccharide (guar gum) forms gel in water
*Endosperm of guar seeds are used in many sectors of industries like mining, petroleum, drilling and textile., food products, pharmaceuticals, cosmetics, water treatment, mining, drilling,confectioneries and many more.
Since a long time Galactomannan polysaccharide (guar gum) can be also named as a hydrocolloid, is treated as the key product for humans and animals as it has a very high nourishing property.



MEDICINAL PROPERTIES OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
*Galactomannan polysaccharide (guar gum)'s healing properties are ideal to cure snakebites and boost the vision and power of the eyes
*The inherent anti-bacterial properties can fight skin diseases like fungal infections and ringworms
*If toddlers face the constipation problem along with fever and cold this remedial measure can be started immediately.
Galactomannan polysaccharide (guar gum) also helps to manage teething issues in children It has potential health maintenance capacities and can fight against typhoid effectively



FUNCTIONS OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
*Fixing agent:
Allows the cohesion of different cosmetic ingredients
*Emulsion Stabilizer:
Aids the emulsification process and improves emulsion stability and shelf life
*Film forming agent:
Produces a continuous film on the skin, hair or nails
*Masking Agent:
Reduces or inhibits base product odor or taste
*Viscosity control agent:
Increases or decreases the viscosity of cosmetics.



WHAT DOES DO IN A FORMULATION?
What does CYAMOPSIS TETRAGONOLOBA GUM do in a formulation?
Binding
Emulsion stabilising
Film forming
Masking
Viscosity controlling



GALACTOMANNAN POLYSACCHARIDE (GUAR GUM) BELONGS TO THE FOLLOWING SUBSTANCE GROUPS:
*Binders
*Film-forming agents
*Perfume / Fragrances
*Stabilisers
*Thickening agents / consistency regulators



FUNCTIONS OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM) IN COSMETIC PRODUCTS:
Function(s) of this ingredient in cosmetic products
*BINDING:
Ensures the cohesion of powdered products
*EMULSION STABILISING:
Supports emulsion formation and improves product stability
*FILM FORMING:
Produces a continuous film on skin, hair and / or nails
*FRAGRANCE:
Enhances the smell of a product and / or perfumes the skin
*VISCOSITY CONTROLLING:
Increases or decreases the viscosity of cosmetic products



WHAT IS GALACTOMANNAN POLYSACCHARIDE (GUAR GUM) OR CLUSTER BEANS?
Galactomannan polysaccharide (guar gum), more commonly known as cluster beans, is an annual legume native of Asia.
Galactomannan polysaccharide (guar gum) is mainly used as a vegetable in different Asian cousins.
The resinous material, Galactomannan polysaccharide (guar gum), made out of guar bean is called guar gum.
One of Galactomannan polysaccharide (guar gum)'s main component, galactomannan polysaccharide, is sort of polymer and the main ingredient responsible for its properties.
However, hydroxypropyl trimonium chloride, another component, Galactomannan polysaccharide (guar gum) is also frequently used in cosmetic products.



WHY IS GALACTOMANNAN POLYSACCHARIDE (GUAR GUM) USED IN COSMETICS AND PERSONAL CARE PRODUCTS?
The following functions have been reported for Galactomannan polysaccharide (guar gum) and the compounds made from Guar Gum:
Antistatic agents:
Guar Hydroxypropyltrimonium Chloride, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride Binders
– Cyamopsis Tetragonoloba (Guar) Gum, Hydroxypropyl Guar Emulsion stabilizers
– Cyamopsis Tetragonoloba (Guar) Gum, Hydroxypropyl Guar Film formers
– Hydroxypropyl Guar Hair conditioning agents
– Guar Hydroxypropyltrimonium Chloride, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride Skin-conditioning agents
- miscellaneous – Guar Hydroxypropyltrimonium Chloride Viscosit increasing agents
- aqueous – Cyamopsis Tetragonoloba (Guar) Gum, Hydroxypropyl Guar, Guar Hydroxypropyltrimonium Chloride



INDUSTRY OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Derivatives of Galactomannan polysaccharide (guar gum) that have been further reacted are used in industrial applications, such as the paper and textile industries, ore flotation, the manufacture of explosives and hydraulic fracturing (fracking) of oil and gas formations.
Galactomannan polysaccharide (guar gum) is often crosslinked with boron or chromium ions to make it more stable and heat-resistant.
The crosslinking of Galactomannan polysaccharide (guar gum) with metal ions results in a gel that does not block the formation and helps efficiently in formation cleaning process.

Galactomannan polysaccharide (guar gum) and its derivatives make gel complexes with ions of Aluminium, Zirconium, Titanium, Chromium and Boron.
The borate–Galactomannan polysaccharide (guar gum) reaction is reversible, and depends on the pH (hydrogen ion concentration) of the solution.
This reaction is used to give the toy "slime" Galactomannan polysaccharide (guar gum)'s consistency.
Crosslinking of Galactomannan polysaccharide (guar gum) with borate occurs at high pH (approximately 9–10) of the solution.
Galactomannan polysaccharide (guar gum) has proven as useful substitute for locust bean gum (made from carob seeds).



USE AND BENEFITS OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Galactomannan polysaccharide (guar gum) is very popular as a thickening agent in food preparation, but it is also used as an antistatic agent, having a polysaccharide structure, it can be understood there are many -OH- and H+ groups to donate.
Thus, Galactomannan polysaccharide (guar gum) can nullify any static produced due to weather or any other reason. Galactomannan polysaccharide (guar gum) forms a film over skin or hair surface and saves moisture loss, which is a primary reason for skin damage.

This way, Galactomannan polysaccharide (guar gum) conditions the skin and hair, by not letting moisture to escape.
Galactomannan polysaccharide (guar gum) also stabilizes emulsions with a similar principle of having many different ion donors and receivers.
Galactomannan polysaccharide (guar gum) also imparts viscosity to any product so it is used as a viscosity adjuster so that the product can look uniform and stability is also not compromised.
Galactomannan polysaccharide (guar gum) is used in bath products, hair care products, shaving creams, skin care products.



PURPOSES OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
*Binding
*Masking
*Film Forming
*Emulsion Stabilizer
*Viscosity Control



FUNCTIONS AND APPLICATIONS OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
1. Viscosity fresh water and brine- based fluids used for drilling, milling, underreaming.
2.Gravel packing operations.Suspend bridging agents
3.Weighting materials in fresh water and brine system



FRACKING AGENT:
The use of Galactomannan polysaccharide (guar gum) in the hydraulic fracturing (fracking) extraction of oil and shale gas has increased demand substantially.
Only 10% of Indian production is used domestically.
The remaining 90% is exported for shale gas and oil industries.
Consequently, many former cotton or wheat fields are converted into guar fields as production costs are lower.
The increase of Galactomannan polysaccharide (guar gum) prices also has other reasons.



GALACTOMANNAN POLYSACCHARIDE (GUAR GUM) IN FOODS:
Galactomannan polysaccharide (guar gum) is primarily used as a thickener, stabilizer, and emulsifier in foods, especially in cold desserts like ice cream, as well as industrial products such as body lotions.

Galactomannan polysaccharide (guar gum) is safe for consumers with celiac disease and is often used in gluten-free recipes as a binding agent.
Galactomannan polysaccharide (guar gum) doesn't need heat to work correctly, it can be added to hot and cold dishes, while still maintaining its thickening abilities.
AddGalactomannan polysaccharide (guar gum) to recipes like salad dressings, smoothies, or stews to create the perfect texture.

With so many applications to use Galactomannan polysaccharide (guar gum), use these measurements as a guideline to help you get started experimenting in the kitchen!
- For cold foods, Salad Dressing, Ice Cream, Puddings, and Custards add 1 - 2 teaspoons per litre of liquid
- For hot foods such as gravy, stews, soups, use 1 - 3 teaspoons per litre of liquid
- For gluten-free cookies use 1/4 to 1/2 teaspoon per cup of flour
- For gluten-free cakes, pancakes, and muffins start with 3/4 teaspoon per cup of flour

-Thicken Sauces and Salad Dressing:
Galactomannan polysaccharide (guar gum) powder doesn’t have much of a taste, but it’s one of the most potent natural thickeners out there.

-Improve the Consistency of Frozen Goods:
Thickening vegan ice cream is one of the most popular Galactomannan polysaccharide (guar gum) uses today.
Galactomannan polysaccharide (guar gum) will give any sorbet a smooth and creamy texture.
Galactomannan polysaccharide (guar gum) also reduces the rate of ice crystal formation.
That’s the reason why Galactomannan polysaccharide (guar gum) powder is often used in frozen goods production.

-Gluten-Free Baking:
Galactomannan polysaccharide (guar gum) should definitely be included in any gluten sensitivity treatment plan as it’s a highly efficient agent for perfect baking
-Homemade Noodles:
Adding Galactomannan polysaccharide (guar gum) powder to homemade noodles will improve their texture and increase the shelf life of the final product.

-Soups:
Like sauces, soups will benefit from the thickening ability of the Galactomannan polysaccharide (guar gum) powder.
Galactomannan polysaccharide (guar gum)’s a perfect addition to creamy mushroom and bean soups.

-Jam:
Galactomannan polysaccharide (guar gum) powder uses in jams are so common, many products sold in stores include this thickener. Galactomannan polysaccharide (guar gum)’s what will allow you to make a jam with the consistency of jellied fruits.



PREPARATION METHOD OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Galactomannan polysaccharide (guar gum) is obtained by drying and pulverizing the endosperm part of the seed of the leguminous plant guar after being peeled off and having the germ removed, subjecting it to hydrolysis under pressure with water, precipitating it with 20% acetic acid, centrifuging it, drying it and pulverizing it.



BIOLOGY OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Galactomannan polysaccharide (guar gum) grows upright, reaching a maximum height of up to 2–3 metres (7–10 ft).
Galactomannan polysaccharide (guar gum) has a main single stem with either basal branching or fine branching along the stem.
Guar taproots can access soil moisture in low soil depths.

This legume develops root nodules with nitrogen-fixing soil bacteria rhizobia in the surface part of its rooting system.
Its leaves and stems are mostly hairy, depending on the cultivar.
Its fine leaves have an elongated oval shape (5 to 10 centimetres (2 to 4 in)) and of alternate position.

Clusters of flowers grow in the plant axil and are white to blueish in color.
The developing pods are rather flat and slim containing 5 to 12 small oval seeds of 5 millimetres (1⁄4 in) length (TGW = 25–40 grams (1–1+1⁄2 oz)).
Usually mature seeds are white or gray, but with excess moisture they can turn black and lose germination capacity. The chromosome number of guar seeds is 2n=14.

The seeds of guar beans have a remarkable characteristic.
Its kernel consists of a protein-rich germ (43-46%) and a relatively large endosperm (34-40%), containing large amounts of the galactomannan.
This is a polysaccharide containing polymers of mannose and galactose in a ratio of 2:1 with many branches.
Thus, it exhibits a great hydrogen bonding activity having a viscosifying effect in liquids.



COMPATIBILITY WITH OTHER HYDROCOLLOIDS OF GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Galactomannan polysaccharide (guar gum) is compatible with most other hydrocolloids and water soluble polymers such as Agar, Arabic, Carrageenan, Karaya, Locust Bean Gum, Pectin, Propylene Glycol Alginate, Sodium Alginate, Tragacanth, Methylcellulose, CMC and Xanthan.
Galactomannan polysaccharide (guar gum) is also compatible with raw starches, most modified starches and many water soluble proteins.



CULTIVATION:
*Climate requirements:
Guar is drought-tolerant and sun-loving, but it is susceptible to frost.
Although it can cope with little but regular rainfall, it requires sufficient soil moisture before planting and during maturation of seeds.

Frequent drought periods can lead to delayed maturation.
On the contrary, excessive moisture during the early growth phase and after maturation lead to lower seed quality.
Guar is also produced near to coastal areas in the Gandhidham region of Kutch, Gujarat, India.

*Soil requirements:
Cyamopsis tetragonoloba (L.) can grow on a wide range of soil types.
Preferably in fertile, medium-textured and sandy loam soils that are well-drained, since waterlogging decreases plant performance.

Guar grows best in moderate alkaline conditions (pH 7-8) and is tolerant of salinity.
Its taproots are inoculated with rhizobia nodules, thus it produces nitrogen-rich biomass and improves soil quality.

*Cultivation areas:
Guar is grown principally in north-western India and Pakistan with smaller crops grown in the semiarid areas of the high plains of Texas in the US, Australia and Africa.
The most important growing area centres on Jodhpur in Rajasthan, India where demand for guar for fractionation produced an agricultural boom as in 2012.

Currently, India is the main producer of cluster bean, accounting for 80% production of the world's total, while the Rajasthan, Gujarat and Kutch regions occupy the largest areas (82.1% of total) dedicated to guar cultivation.
In addition to its cultivation in India, the crop is also grown as a cash crop in other parts of the world.
Several commercial growers have converted their crops to guar production to support the increasing demand for guar and other organic crops in the United States.



GALACTOMANNAN POLYSACCHARIDE (GUAR GUM) POWDER:
The color of Galactomannan polysaccharide (guar gum) powder is whitish and yellowish consisting of slight odor.
Cyamopsis tetragonolobus or Guar Plants endosperm derives Galactomannan polysaccharide (guar gum).
Guar crop is basically a legume (a plant of a pea family) which grows effectively in sandy soils, with rainfall to some extent with lots of sunshine.

Food Grade Galactomannan polysaccharide (guar gum) powder is obtained from ground endosperm of guar plant.
The seed pods of Guar are grown in groups, 100 Kilos of beans, minus their bean pods yields roughly 29 kilos of endosperm; 29 kilos of Guar powder.
India Followed by Pakistan and US is the key producer of Guar Seeds constituting approximately 80% of the over all production.

Guar crop grows on semi arid and sub-tropical area harvested between Octobers to November.
Guar seed is the combination of three things the germ, endosperm and the husk.
Guar seed is basically the legume which regenerates the nitrogen in soil.

Green Guar is the source of vegetables and also fed to cattle’s.
Galactomannan polysaccharide (guar gum) can also be termed as the best and appropriate substitute for locust bean gum.
We offer goma guar as well as gomme guar from India.

Guar seeds are instantaneously sown after the first drizzles of the onset of monsoon i.e. in July.
The Hay of Guar is very nutritive making it a good fodder when mixed with wheat powder.
Guar seed can also be called as a cluster bean.

This Kharif legume is a highly nutritious crop used as green manure, vegetable and green fodder.
Galactomannan polysaccharide (guar gum) is extracted from Guar seeds and is grounded transforming it into Galactomannan polysaccharide (guar gum) Powder.



PHYSICAL and CHEMICAL PROPERTIES of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
Physical state: powder
Color: beige
Odor: No data available
Melting point/freezing point: no data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Appearance: White-like powder
Storage Condition: Room Temprature



FIRST AID MEASURES of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
-Environmental precautions:
No special environmental precautions required.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Choose body protection.
*Respiratory protection:
Respiratory protection is not required.
-Control of environmental exposure:
No special environmental precautions required.



HANDLING and STORAGE of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
-Precautions for safe handling:
*Hygiene measures:
General industrial hygiene practice.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids



STABILITY and REACTIVITY of GALACTOMANNAN POLYSACCHARIDE (GUAR GUM):
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
Goma de guar
Gomma di Guar
Guar gum
Guarkernmehl
Guar
A-20D
J 2Fp
1212A
Guaran
Jaguar
Decorpa
Regonol
Guar gum
Uni-Guar
Gum guar
Lycoid DR
CCRIS 321
HSDB 1904
Indalca AG
Dealca TP1
Guar flour
Galactasol
Dealca TP2
NCI-C50395
Gendriv 162
Rein guarin
Supercol GF
Jaguar plus
Jaguar 6000
Jaguar A 40F
Jaguar A 20D
Syngum D 46D
Gum cyamopsis
Indalca AG-HV
FEMA No. 2537
Jaguar No.124
Supercol G.F.
Indalca AG-BV
Cyamopsis gum
Jaguar A 20 B
Guar gum, ext.
Burtonite V-7-E
UNII-E89I1637KE
Jaguar gum A-20-D
Supercol U powder
Guar Gum Seed Endosperm
Solvent purified guar gum
Guar gum (cyamopsis tetragonolobus)
Guar gum (Cyamopsis tetragonolobus (L.))
Cyamopsis tetragonoloba (L.) Taub. (Fabaceae)
Guar gum
Guar gum [NF]
Guaran
1212A
A-20D
Burtonite V-7-E
CCRIS 321
Cyamopsis gum
Cyamopsis tetragonoloba (L.) Taub. (Fabaceae)
Dealca TP1
Dealca TP2
Decorpa
EINECS 232-536-8
FEMA No. 2537
Galactasol
Gendriv 162
Guar
Guar flour
Guar gum
Guar gum (Cyamopsis tetragonolobus (L.))
Guar gum (cyamopsis tetragonolobus)
Guar Gum Seed Endosperm
Guaran
Gum cyamopsis
Gum guar
HSDB 1904
Indalca AG
Indalca AG-BV
Indalca AG-HV
J 2Fp
Jaguar
Jaguar 6000
Jaguar A 20 B
Jaguar A 20D
Jaguar A 40F
Jaguar gum A-20-D
Jaguar No.124
Jaguar plus
Lycoid DR
NCI-C50395
Regonol
Rein guarin
Solvent purified guar gum
Supercol G.F.
Supercol GF
Supercol U powder
Syngum D 46D
Uni-Guar
UNII-E89I1637KE
Guar gum
Guar gum
9000-30-0
E89I1637KE
1312293-38-1
53986-27-9
57406-68-5
57406-71-0
63799-54-2
85510-16-3
9008-17-7
9010-50-8
9049-33-6
9066-07-3


GARAMITE-1958
Garamite-1958 is a powdered rheology and thixotropic additive based on a composition of organically modified phyllosilicates.
Garamite-1958 increases storage stability and sag resistance.
The combination of various morphological structures in the mineral components results in it being particularly easy to disperse and offering high efficiency in various unsaturated polyester and vinylester-based resins.

CAS Number: 68911-87-5



APPLICATIONS


Garamite-1958 is used in the formulation of adhesives and sealants for its thickening and rheology control properties.
Garamite-1958 is used as a suspending agent in the production of ceramics and refractories.

Garamite-1958 is used in the manufacturing of drilling muds for its excellent rheology control and filtration properties.
Garamite-1958 is used in the production of paints and coatings for its thickening and anti-settling properties.

Garamite-1958 is used in the production of personal care products such as lotions and creams for its thickening and stabilizing properties.
Garamite-1958 is used as a binder and thickener in the production of carbon fiber composites to improve strength and adhesion.
Garamite-1958 is used as a rheological additive in oil-based drilling fluids to control fluid loss and increase viscosity.

Garamite-1958 is used in the production of ceramic filters to enhance plasticity, strength, and surface finish.
Garamite-1958 is used in the production of polymer-based coatings to improve stability and prevent settling.

Garamite-1958 is used in the production of refractory materials for high-temperature applications as a binder and thickener.
Garamite-1958 is used in the production of geothermal drilling muds to improve viscosity and prevent solids settling.

Garamite-1958 is used as a thickener and suspending agent in water-based coatings and paints to improve stability.
Garamite-1958 is used in the production of ceramic capacitors as a binder and thickener to enhance plasticity and strength.

Garamite-1958 is used in the production of synthetic fibers as a thickener to improve processing and reduce costs.
Garamite-1958 is used in the production of cosmetics such as lotions and creams to improve stability and texture.

Garamite-1958 is used as a thickener in toothpaste formulations to improve texture and mouthfeel.
Garamite-1958 is used as a binder in the production of catalyst supports to improve strength and thermal stability.
Garamite-1958 is used in the production of asphalt emulsions as a thickener and stabilizer to improve performance.

Garamite-1958 is used in the production of animal feed as a binder and pelletizing agent to improve quality and consistency.
Garamite-1958 is used as a thickener and stabilizer in latex paints to improve stability and consistency.

Garamite-1958 is used in the production of refractory castables to enhance flowability and workability.
Garamite-1958 is used in the production of ceramic fibers as a binder and thickener to enhance strength and thermal stability.

Garamite-1958 is used in the production of detergents and cleaning products as a thickener and stabilizer to improve efficacy and stability.
Garamite-1958 is used in the production of thermoplastics as a processing aid to improve extrusion and molding.

Garamite-1958 is used in the production of pharmaceuticals such as tablets and capsules as a binder and thickener to improve manufacturability.
Garamite-1958 is used as a thickener and suspending agent in personal care products such as shampoos and conditioners to improve texture and stability.

Garamite-1958 is used in the production of printing inks as a thickener and stabilizer to improve print quality and consistency.
Garamite-1958 is used as a binder and thickener in the production of wood adhesives to improve adhesion and water resistance.
Garamite-1958 is used as a thickener in drilling muds for tunneling applications to improve viscosity and prevent solids settling.

Garamite-1958 is used as a rheological additive in oil drilling fluids to increase viscosity and control fluid loss.
Garamite-1958 is used in the construction industry as a thickener and stabilizer for cement, grouts, and mortars.

Garamite-1958 is used in the production of ceramics to improve plasticity, strength, and surface finish.
Garamite-1958 is used as a binder and thickener in the production of refractory materials for high-temperature applications.

Garamite-1958 is used as a suspending agent and thickener in paints and coatings to improve stability and prevent settling.
Garamite-1958 is used in the production of adhesives and sealants as a rheological modifier to improve viscosity and adhesion.

Garamite-1958 is used in the food industry as a stabilizer, thickener, and gelling agent in products such as sauces, dressings, and desserts.
Garamite-1958 is used in the pharmaceutical industry as a binder and thickener for tablets, capsules, and topical formulations.

Garamite-1958 is used in the personal care industry as a thickener and stabilizer in cosmetic formulations such as creams, lotions, and shampoos.
Garamite-1958 is used in the textile industry as a thickener and stabilizer in printing pastes and as a sizing agent for fabrics.
Garamite-1958 is used in the production of batteries as a binder to hold electrode materials together.

Garamite-1958 is used in the production of drilling muds for geothermal wells.
Garamite-1958 is used in the production of ceramics for electronic applications, such as multilayer capacitors.

Garamite-1958 is used in the production of emulsion explosives as a gelling agent to improve stability and control detonation.
Garamite-1958 is used in the production of foundry sand binders to improve strength and reduce defects.

Garamite-1958 is used in the production of inkjet printing inks as a thickener and stabilizer to improve print quality.
Garamite-1958 is used in the production of paper coatings to improve smoothness and printability.
Garamite-1958 is used in the production of personal lubricants as a thickener to improve lubrication and prolong effectiveness.

Garamite-1958 is used in the production of synthetic rubber to improve processing and reduce costs.
Garamite-1958 is used in the production of thermal insulation materials to improve strength and thermal stability.

Garamite-1958 is used in the production of welding rods as a binder to hold the filler material together.
Garamite-1958 is used in the production of wood adhesives to improve adhesion and water resistance.

Garamite-1958 is used in the production of wound dressings as a thickener to improve adhesion and prevent leakage.
Garamite-1958 is used in the production of metalworking fluids to improve lubrication and reduce friction.

Garamite-1958 is used in the formulation of adhesives and sealants for its thickening and rheology control properties.
Garamite-1958 is used as a suspending agent in the production of ceramics and refractories.

Garamite-1958 is used in the manufacturing of drilling muds for its excellent rheology control and filtration properties.
Garamite-1958 is used in the production of paints and coatings for its thickening and anti-settling properties.


Some areas of applications for Garamite-1958:

Oil and gas industry
Construction industry
Ceramic industry
Refractory industry
Paints and coatings industry
Adhesives and sealants industry
Food industry
Pharmaceutical industry
Personal care industry
Textile industry
Battery industry
Geothermal industry
Electronic industry
Explosives industry
Foundry industry
Printing industry
Paper industry
Lubricants industry
Rubber industry
Thermal insulation industry
Welding industry
Wood adhesives industry
Wound dressings industry
Metalworking fluids industry
Detergents industry.


Garamite-1958 is used in the production of personal care products such as lotions and creams for its thickening and stabilizing properties.
Garamite-1958 is used in the production of latex paint to improve flow and leveling.

Garamite-1958 is used as a binder and thickener in the production of ceramic membranes for water treatment.
Garamite-1958 is used in the production of printing inks for gravure and flexographic printing.
Garamite-1958 is used as a thickener and stabilizer in the production of personal care products such as deodorants and toothpaste.

Garamite-1958 is used as a gelling agent in the production of cosmetic products such as facial masks and body scrubs.
Garamite-1958 is used in the production of adhesives for the woodworking industry to improve bonding strength.

Garamite-1958 is used in the production of artificial stone and solid surfaces for the construction industry.
Garamite-1958 is used as a binder in the production of abrasive materials such as grinding wheels and sandpaper.

Garamite-1958 is used as a rheology modifier in the production of drilling muds for oil and gas wells.
Garamite-1958 is used in the production of high-performance coatings for industrial and automotive applications.

Garamite-1958 is used as a thickener and stabilizer in the production of pet food and animal feed.
Garamite-1958 is used as a binder and rheology modifier in the production of refractory bricks and castables.

Garamite-1958 is used as a thickener and stabilizer in the production of household cleaning products such as dishwashing liquids and laundry detergents.
Garamite-1958 is used in the production of polymer concrete to improve strength and durability.
Garamite-1958 is used in the production of high-performance coatings for the aerospace industry.

Garamite-1958 is used as a thickener and stabilizer in the production of drilling fluids for geothermal wells.
Garamite-1958 is used in the production of high-strength concrete to improve workability and compressive strength.

Garamite-1958 is used as a rheology modifier in the production of hydraulic fracturing fluids.
Garamite-1958 is used in the production of ceramic tiles to improve adhesion and water resistance.
Garamite-1958 is used as a binder and thickener in the production of advanced composites for aerospace and defense applications.

Garamite-1958 is used as a thickener and stabilizer in the production of paints and coatings for marine applications.
Garamite-1958 is used in the production of detergents and surfactants as a thickener and rheology modifier.

Garamite-1958 is used as a binder and thickener in the production of industrial ceramics such as kiln furniture and refractory lining.
Garamite-1958 is used as a rheology modifier in the production of personal care products such as hair styling gels and lotions.
Garamite-1958 is used in the production of building materials such as concrete blocks and paving stones to improve strength and durability.



DESCRIPTION


Garamite-1958 is a powdered rheology and thixotropic additive based on a composition of organically modified phyllosilicates.
Garamite-1958 increases storage stability and sag resistance.
The combination of various morphological structures in the mineral components results in it being particularly easy to disperse and offering high efficiency in various unsaturated polyester and vinylester-based resins.

Garamite-1958 offers higher coating thicknesses and strong shear thinning effect.
Garamite-1958 also offers higher bulk densities compared with pyrogenic silica which means lower dusting and less storage space required and greater efficiency and/or lower dosage.

Garamite-1958 is particularly suited to formulating PVC plastisols.
Garamite-1958 provides pseudoplastic flow, broad compatibility with various plasticizers and greater effectiveness than precipitated fillers.

Garamite-1958 is easy to incorporate and has no impact on the VOC content.
The recommended level for PVC plastisols is 1-5% additive (as supplied) based upon the total formulation, depending on the properties of the formulation to be achieved.

Garamite-1958 is listed in EINECS, TSCA, DSL, AICS, PICCS, IECSC, ENCS, NZIoC and ECSI.
Garamite-1958 is in line with EU Directive 2011/65/EC (RoHS 2), EU Directive 2002/96/EC (WEEE), EU Directive 94/62/EC (Packaging Waste), CONEG Toxics in Packaging. It complies with REACH Regulation (EC) No 1907/2006.
The shelf life of Garamite-1958 is 60 months.

Garamite-1958 is a type of bentonite clay that is used as a rheological additive in a variety of industries.
Garamite-1958 is produced by the Georgia Industrial Minerals company and is commonly used in the oil and gas drilling industry.
Garamite-1958 is a natural product that is formed from volcanic ash deposits and is known for its high swelling and rheological properties.

Garamite-1958 is a highly effective viscosifier and suspension agent, making it ideal for use in drilling muds, cement slurries, and other fluids used in the oil and gas industry.
Garamite-1958 can also be used in water-based paints and coatings to improve viscosity and rheology.

Garamite-1958 is known for its ability to maintain stability and prevent fluid loss in high-temperature and high-pressure environments, making it a popular choice for use in challenging drilling conditions.
Garamite-1958 is also used in the construction industry as a binder in cement and mortar formulations, and as a thickener in grouts and other construction materials.
Its ability to improve workability and reduce shrinkage makes it an ideal additive for a variety of construction applications.

Other applications of Garamite-1958 include use as a rheological additive in adhesives, sealants, and caulks, as well as in foundry and ceramics applications for its ability to improve green strength and casting quality.
Garamite-1958 is typically available in powder form and should be stored in a dry, cool place to prevent moisture absorption and maintain product quality.
It is important to follow proper handling and safety procedures when working with bentonite clays to avoid inhalation and skin contact.


Garamite-1958 is a type of organoclay with several unique properties, including:

Rheological properties:

Garamite-1958 can significantly increase the viscosity of liquids, making it useful as a thickening agent in various industries.


Suspension properties:

The organoclay can suspend solid particles in liquids, preventing settling and improving stability.


Thixotropy:

Garamite-1958 exhibits thixotropic behavior, meaning it becomes less viscous when subjected to stress and returns to its original viscosity when the stress is removed.


Chemical stability:
The organoclay is highly resistant to chemical reactions, making it suitable for use in harsh environments.


Thermal stability:
Garamite-1958 can withstand high temperatures without degrading, making it useful in high-temperature applications.


Water resistance:
The organoclay is highly resistant to water, making it useful in products that need to be water-resistant or used in wet environments.


Compatibility:
Garamite-1958 is compatible with a wide range of solvents and binders, making it useful in many different formulations.


Shear thinning:
The organoclay exhibits shear-thinning behavior, meaning it becomes less viscous when subjected to shear forces, allowing for easy processing and application.


Non-toxicity:
Garamite-1958 is non-toxic and safe for use in various industries, including the food and pharmaceutical industries.



PROPERTIES


Molecular weight: Varies based on the specific composition
Appearance: Fine white powder
Solubility: Insoluble in water, organic solvents, and oils
pH: Varies based on the specific composition
Density: Varies based on the specific composition
Melting point: Varies based on the specific composition
Flash point: Not applicable, as it is not flammable
Vapor pressure: Not applicable, as it does not evaporate at normal temperatures
Stability: Stable under normal conditions of use and storage
Reactivity: Not reactive with water, but may react with some strong acids or bases.
Specific surface area: 20-25 m²/g
Thermal stability: Stable up to 300°C
Refractive index: 1.5-1.7 (depending on particle size and method of measurement)
Particle size: 5-50 microns (typical range)
Color: White to light beige



FIRST AID


Here are the first aid measures for Garamite-1958:

If inhaled:

Move the affected person to an area with fresh air.
If the person is not breathing, provide artificial respiration.
Seek medical attention if symptoms persist.


If on skin:

Remove contaminated clothing and wash the affected area with soap and water.
Seek medical attention if irritation or redness occurs.


If in eyes:

Rinse the eyes with water for several minutes, while holding the eyelids open.
If the person wears contact lenses, remove them if it is easy to do so.
Seek medical attention if irritation or pain persists.


If swallowed:

Rinse the mouth with water and drink plenty of water to dilute the substance.
Seek medical attention immediately.


If the substance has been injected:

Seek medical attention immediately.


Note:

It is important to seek medical attention if exposure to Garamite-1958 has occurred, as this substance may cause respiratory, skin, and eye irritation, and can be harmful if ingested or injected.



HANDLING AND STORAGE


Handling:

Avoid inhalation, ingestion, and skin contact with the substance.
Use appropriate protective equipment such as gloves, safety glasses, and respirators if necessary.

Ensure good ventilation in the work area to avoid the accumulation of dust or vapors.
Do not smoke, eat, or drink while handling the substance.
Clean any contaminated equipment or surfaces with appropriate cleaning agents.


Storage:

Store Garamite-1958 in a dry, cool, and well-ventilated area.
Keep the substance in a tightly sealed container to prevent moisture absorption and contamination.

Store away from sources of heat, sparks, or flames.
Keep the substance away from incompatible materials such as strong oxidizing agents or acids.
Follow all local regulations and guidelines for storage and handling of the substance.



SYNONYMS

Organoclay
Montmorillonite
Bentonite
Rheological additive
Thickening agent
Stabilizing agent
Gelling agent
Binder
Rheology modifier
Suspension agent
Viscosifier
Plasticizer
Emulsifier
Gel former
Clay mineral
Natural clay
Modified clay
Nanoclay
Smectite clay
Layered silicate
Inorganic clay
Sorptive clay
Flocculating agent
Coagulating agent
Organophilic clay
Montmorillonite clay
Bentonite clay
Smectite clay
Modified clay
Rheological clay
Thickening clay
Viscosifying clay
Gel-forming clay
Swelling clay
Adsorptive clay
Gelling clay
Plastic clay
Emulsion stabilizing clay
Suspension stabilizing clay
Drilling clay
Casting clay
Coating clay
Emulsifying clay
Sealing clay
Flocculating clay
Binding clay
Lubricating clay
Absorbing clay
Flocculant
Adsorbent
Emulsifier
Gellant
Thixotropic agent
Suspension agent
GARAMITE-7305
Garamite-7305 acts as a thickening agent.
Garamite-7305 is developed using Mixed Mineral Thixotrope (MMT) technology.
Garamite-7305 exhibits a very unique rheology profile compared to other thickening additives.


INCI Name: Benzalkonium Sepiolite (and) Benzalkonium Montmorillonite


Garamite-7305 was developed using patented Mixed Mineral Thixotrope (MMT) technology.
The MMT technology provides performance benefits which are not possible with traditional organoclay additives.
Traditional organoclays are very hard to disperse, typically requiring both very high shear mixing and a polar activator to help delaminate the aggregates of clay platelets.


Due to the multiple particle morphologies of Garamite-7305, the powder disperses very easily into oils or solvents with only moderate shear.
Garamite-7305 is very high low-shear viscosity can be achieved by incorporating it into formulations which results in outstanding anti-settling and anti-syneresis properties.
However, when a shear force is applied, the viscosity is quickly reduced which allows for excellent application properties and skin feel.


Garamite-7305 exhibits a very unique rheology profile compared to other thickening additives.
Garamite-7305 has high low-shear viscosity can be achieved by incorporating it into formulations which result in outstanding ant-settling and anti-syneresis properties.
However, when a shear force is applied, the viscosity is quickly reduced which allows for excellent application properties.


Garamite-7305 is most suited for medium to high polarity systems.
Garamite-7305 is a powdered rheology additive for polar solvent-borne and solvent-free systems to increase storage stability and sag resistance.
Garamite-7305 offers benefits over conventional organophilic phyllosilicates (organoclays).


Garamite-7305 is conventional phyllosilicates typically require incorporation at high shear forces and polar activators to support dispersion.
In contrast, Garamite-7305 can be easily incorporated and activated in solvents and binders under moderate shear force.
The additive, Garamite-7305, has a highly pseudoplastic viscosity profile.


Garamite-7305 makes it possible to produce formulations with high viscosity in the low shear range, which results in outstanding anti-settling and anti-syneresis properties. Garamite-7305 is applying shear force that causes a strong reduction in viscosity which significantly improves the application properties.
Garamite-7305 was developed using patented Mixed Mineral Thixotrope (MMT) technology.


The MMT technology provides performance benefits which are not possible with traditional organoclay additives.
Traditional organoclays are very hard to disperse, typically requiring both very high shear mixing and a polar activator to help delaminate the aggregates of clay platelets.


Due to the multiple particle morphologies of Garamite-7305, the powder disperses very easily into oils or solvents with only moderate shear.
Garamite-7305 exhibits a very unique rheology profile compared to other thickening additives.
Garamite-7305 is very high low-shear viscosity can be achieved by incorporating this product into formulations which results in outstanding ant-settling and anti-syneresis properties.


However, when a shear force is applied, the viscosity is quickly reduced which allows for excellent application properties.
Garamite-7305 was developed using Southern Clay Products’ patented Mixed Mineral Thixotrope (MMT) technology.
The MMT technology provides performance benefits which are not possible with traditional organoclay additives.


Traditional organoclays are very hard to disperse, typically requiring both very high shear mixing and a polar activator to help delaminate the aggregates of clay platelets.
Due to the multiple particle morphologies of Garamite-7305, the powder disperses very easily into oils or solvents with only moderate shear.


Garamite-7305 exhibits a very unique rheology profile compared to other thickening additives.
Garamite-7305 has very high low-shear viscosity can be achieved by incorporatingGaramite-7305 into formulations which results in outstanding ant-settling and anti-syneresis properties.


However, when a shear force is applied, the viscosity is quickly reduced which allows for excellent application properties.
Garamite-7305 is most suited for medium to high polarity systems.



USES and APPLICATIONS of GARAMITE-7305:
The organoclays Garamite-7305 is ideally suited to the task of suspending these particles and adjusting a shear thinning flow behavior with good residual emptying of the bottles, and generate highly temperature stable rheological properties
Garamite-7305 is due to the extremely polar surface coating for use in highly polar systems such as butyl acetate, ethyl acetate, acetone and alcohols as well as for corresponding high solid and 100 percent resin applications.


Garamite-7305 is used Medium to high polarity, Solvent-borne system
Garamite-7305 is used for medium to high polarity.
Garamite-7305 may be used in all medium to high polarity organic fluid systems.


Garamite-7305 is used in sun care, skin care products and nail lacquers.
Garamite-7305 is a powdered rheology additive for polar solvent-borne and solvent-free systems to increase storage stability and sag resistance.
Garamite-7305 offers benefits over conventional organophilic phyllosilicates (organoclays).


Garamite-7305 is conventional phyllosilicates typically require incorporation at high shear forces and polar activators to support dispersion.
In contrast, Garamite-7305 can be easily incorporated and activated in solvents and binders under moderate shear force.
Garamite-7305 is ideally suited to non-polar and medium-polar systems in the following applications: architectural, protective and industrial.
Garamite-7305 is most suited for medium to high polarity systems.



SPECIAL FEATURES AND BENEFITS OF GARAMITE-7305:
Garamite-7305 is a rheology additive that offers benefits over conventional organophilic phyllosilicates(organoclays).
Conventional phyllosilicates typically require incorporation at high shear forces and polar activators to support dispersion.
In contrast, Garamite-7305 can be easily incorporated and activated in solvents and binders under moderate shear force.
The additive has a highly pseudoplastic viscosity profile.
Garamite-7305 makes it possible to produce formulations with high viscosity in the low shear range, which results in outstanding anti-settling and anti-syneresis properties.
Applying shear force causes a strong reduction in viscosity whichsignificantly improves the application properties.



BENEFITS OF GARAMITE-7305:
Powdered rheology additive for polar solvent-borne and solvent-free systems to increase the storage stability and sag resistance.



PHYSICAL and CHEMICAL PROPERTIES of GARAMITE-7305:
Appearance: solid
Auto Ignition Temperature: 340 °C (644 °F)
Color: off-white
Flash Point: Not applicable
Lower Explosion Limit: 1.00 %(V)
Odor: odorless
Relative Density: 1.50 - 1.80 Reference Material: (water = 1)
Solubility in Water: insoluble
Appearance : powder
Colour : off-white
Odour : odourless
Odour Threshold : No data available

pH : No data available
Melting point/freezing point : Not applicable
Boiling point/boiling range : Not applicable
Vapour pressure : Not applicable
Flash point : Not applicable
Upper explosion limit : Not applicable
Lower explosion limit : Not applicable
Evaporation rate : Not applicable
Flammability (solid, gas) : May form combustible dust concentrations in air.
Minimum Explosible
Concentration: 100 g/m3
Relative vapour density : Not applicable

Relative Density/Specific:
Gravity: No data available
Density : No data available
Solubility(ies):
Water solubility : insoluble
Solubility in other solvents : No data available
Partition coefficient: noctanol/water : No data available
Auto-ignition temperature : 644 °F (340 °C)
Method: Minimum Ignition Temperature (layer): 1022 °F (550 °C)
Method: Minimum Ignition Temperature (cloud)
Thermal decomposition : No data available
Viscosity
Viscosity, dynamic : No data available



FIRST AID MEASURES of GARAMITE-7305:
-If inhaled :
If symptoms persist, call a physician.
-In case of skin contact :
Remove contaminated clothing.
Wash thoroughly with soap and water.
-In case of eye contact :
Flush eyes with water as a precaution.
Remove contact lenses.
Keep eye wide open while rinsing.
-If swallowed :
Keep respiratory tract clear.
Do not give milk or alcoholic beverages.
-Most important symptoms and effects, both acute and delayed :
No information available.



ACCIDENTAL RELEASE MEASURES of GARAMITE-7305:
-Environmental precautions :
Prevent further leakage or spillage if safe to do so.
-Methods and materials for containment and cleaning up :
Contain spillage, pick up with an electrically protected vacuum cleaner or by wet-brushing and transfer to a container for disposal according to local regulations.



FIRE FIGHTING MEASURES of GARAMITE-7305:
-Suitable extinguishing media :
Alcohol-resistant foam
Carbon dioxide (CO2)
Dry chemical
-Unsuitable extinguishing media:
No information available.
-Specific hazards during firefighting:
Handle as an industrial chemical.
Cool closed containers exposed to fire with water spray.



EXPOSURE CONTROLS/PERSONAL PROTECTION of GARAMITE-7305:
-Engineering measures :
Use with local exhaust ventilation.
-Personal protective equipment:
*Hand protection
Material :
Impervious glove
*Eye protection :
Eye wash bottle with pure water
Tightly fitting safety goggles
-Hygiene measures :
Wash hands before breaks and at the end of workday



HANDLING and STORAGE of GARAMITE-7305:
-Advice on safe handling:
Smoking, eating and drinking should be prohibited in the application area.
Dispose of rinse water in accordance with local and national regulations.
-Conditions for safe storage :
Keep container tightly closed in a dry and well-ventilated place.
-Materials to avoid :
No materials to be especially mentioned.



STABILITY and REACTIVITY of GARAMITE-7305:
-Reactivity :
No decomposition if stored and applied as directed.
-Chemical stability :
No decomposition if stored and applied as directed.
-Incompatible materials :
No data available
Hazardous decomposition products:
No data available



GARAMITE-7308 XR
Garamite-7308 XR is a rheology additive used in oil and solvent-based cosmetic applications.
Garamite-7308 XR is a blend of quaternium-90 sepiolite and quaternium-90 montmorillonite, which are both types of layered silicates.

CAS Number: 126825-29-8



APPLICATIONS


Garamite-7308 XR has various applications in the cosmetics industry, primarily as a rheology modifier for oil and solvent-based formulations.
Garamite-7308 XR can be used in a range of products such as creams, lotions, sunscreens, and other personal care items to improve texture, stability, and viscosity.
Garamite-7308 XR can also be used in the pharmaceutical industry as a binder and disintegrant for tablets and capsules.

Garamite-7308 XR is used as a rheology additive in oil-based cosmetic products such as creams and lotions.
Garamite-7308 XR is used as a thickener and emulsion stabilizer in skin care formulations.
Garamite-7308 XR is used as a viscosity modifier in hair care products.

Garamite-7308 XR is used as a conditioning agent in shampoos and conditioners.
Garamite-7308 XR is used as a binder in pressed powder and eye shadow formulations.

Garamite-7308 XR is used as a texturizing agent in styling products like hair gels and mousses.
Garamite-7308 XR is used as a suspension agent in sunscreens and other emulsions.

Garamite-7308 XR is used as a rheology modifier in deodorants and antiperspirants.
Garamite-7308 XR is used as a thickener and stabilizer in lipsticks and lip glosses.

Garamite-7308 XR is used as a gelling agent in facial masks and body scrubs.
Garamite-7308 XR is used as a binding agent in powder-based cosmetics such as blushes and bronzers.

Garamite-7308 XR is used as a filler in powders and foundations.
Garamite-7308 XR is used as a texture enhancer in shaving creams and foams.
Garamite-7308 XR is used as a rheology modifier in body lotions and moisturizers.

Garamite-7308 XR is used as a suspending agent in sunless tanning lotions and sprays.
Garamite-7308 XR is used as a thickener and emulsion stabilizer in body washes and shower gels.

Garamite-7308 XR is used as a binder in stick-based products such as deodorants and lip balms.
Garamite-7308 XR is used as a viscosity modifier in bath oils and salts.

Garamite-7308 XR is used as a texturizing agent in hair coloring products.
Garamite-7308 XR is used as a suspension agent in face and body scrubs.

Garamite-7308 XR is used as a thickener and emulsion stabilizer in facial cleansers.
Garamite-7308 XR is used as a rheology modifier in hand and foot creams.


Garamite-7308 XR has several areas of applications, including:

Cosmetics:

Garamite-7308 XR is used as a rheology modifier in oil and solvent-based cosmetic formulations, providing thickening and stabilizing effects.


Personal care:

Garamite-7308 XR is used in a variety of personal care products, including lotions, creams, and sunscreens, to enhance their texture and stability.


Pharmaceuticals:

Garamite-7308 XR is used as a suspending agent in pharmaceutical formulations to improve the stability and consistency of the product.


Paints and coatings:

Garamite-7308 XR is used as a rheology modifier and thickening agent in paints and coatings to improve their application properties.


Adhesives:

Garamite-7308 XR is used as a thickener and rheology modifier in adhesive formulations to improve their stability and adhesion properties.


Inks:

Garamite-7308 XR is used as a thickener and rheology modifier in ink formulations to improve their printability and consistency.


Oil and gas drilling:

Garamite-7308 XR is used as a viscosifier and rheology modifier in oil and gas drilling fluids to improve their performance and efficiency.


Construction:

Garamite-7308 XR is used in construction applications, such as grouts and mortars, to enhance their workability and stability.


Agriculture:

Garamite-7308 XR is used in agricultural formulations, such as herbicides and pesticides, to improve their suspension and stability properties.


Ceramics:

Garamite-7308 XR is used in ceramic formulations, such as glazes and engobes, to improve their rheological properties.


Rubber and plastics:

Garamite-7308 XR is used as a filler and reinforcement agent in rubber and plastic formulations, providing improved mechanical properties.


Textiles:

Garamite-7308 XR is used in textile printing applications as a thickener and rheology modifier to improve the printing quality and consistency.


Food:

Garamite-7308 XR is used as a thickener and stabilizer in food products, such as sauces, dressings, and soups.


Paper and pulp:

Garamite-7308 XR is used in paper and pulp applications as a retention aid and drainage aid to improve the efficiency of the process.


Mining:

Garamite-7308 XR is used as a flocculant and settling aid in mining applications to improve the separation of solids and liquids.


Water treatment:

Garamite-7308 XR is used in water treatment applications as a coagulant and flocculant to remove suspended solids and impurities.


Personal hygiene:

Garamite-7308 XR is used in personal hygiene products, such as wet wipes and sanitary napkins, to improve their texture and stability.


Cleaning products:

Garamite-7308 XR is used in cleaning products, such as detergents and degreasers, to improve their viscosity and stability.


Metalworking:

Garamite-7308 XR is used as a lubricant and anti-wear additive in metalworking fluids to improve the efficiency of the process.


Automotive:

Garamite-7308 XR is used in automotive applications, such as brake fluids and coolants, to improve their viscosity and stability.


Electronics:

Garamite-7308 XR is used in electronic applications, such as encapsulants and adhesives, to improve their viscosity and adhesion properties.


Marine:

Garamite-7308 XR is used in marine applications, such as coatings and sealants, to improve their performance and durability.


Aerospace:

Garamite-7308 XR is used in aerospace applications, such as adhesives and sealants, to improve their performance and durability.


Renewable energy:

Garamite-7308 XR is used in renewable energy applications, such as wind turbine blades and solar panels, to improve their performance and durability.


Garamite-7308 XR is used as a binding agent in pressed powders and compact foundations.
Garamite-7308 XR is used as a texturizing agent in volumizing hair sprays.
Garamite-7308 XR is used as a rheology modifier in facial serums and treatments.

Garamite-7308 XR is used as a suspension agent in leave-on hair treatments.
Garamite-7308 XR is used as a thickener and emulsion stabilizer in body lotions and creams.

Garamite-7308 XR is used as a binder in eye and lip pencils.
Garamite-7308 XR is used as a texturizing agent in hair pomades and waxes.

Garamite-7308 XR is used as a viscosity modifier in beard oils and balms.
Garamite-7308 XR is used in the formulation of hair styling products to improve hold and texture.

Garamite-7308 XR is used in nail polish formulations as a thickener and suspending agent.
Garamite-7308 XR is used in sunscreens and other UV protection products to improve texture and stability.
Garamite-7308 XR is used in lipsticks and lip glosses to improve texture and shine.

Garamite-7308 XR is used in deodorants and antiperspirants to improve texture and stability.
Garamite-7308 XR is used in body lotions and creams to improve texture and skin feel.

Garamite-7308 XR is used in facial masks and other skincare products to improve texture and ease of application.
Garamite-7308 XR is used in shaving creams and gels to improve texture and provide lubrication.

Garamite-7308 XR is used in hand sanitizers to improve texture and moisturizing properties.
Garamite-7308 XR is used in oral care products such as toothpaste and mouthwash to improve texture and mouthfeel.
Garamite-7308 XR is used in bath products such as shower gels and bath salts to improve texture and skin feel.

Garamite-7308 XR is used in hair dye formulations to improve texture and provide viscosity control.
Garamite-7308 XR is used in body scrubs and exfoliants to improve texture and provide mild abrasion.

Garamite-7308 XR is used in massage oils and creams to improve texture and provide lubrication.
Garamite-7308 XR is used in pet grooming products such as shampoos and conditioners to improve texture and ease of application.

Garamite-7308 XR is used in fabric softeners to improve texture and provide fragrance retention.
Garamite-7308 XR is used in household cleaning products to provide viscosity control and suspend abrasive particles.
Garamite-7308 XR is used in automotive cleaning products such as car waxes and polishes to improve texture and provide abrasion resistance.

Garamite-7308 XR is used in industrial coatings and adhesives to improve rheology and prevent settling.
Garamite-7308 XR is used in printing inks and coatings to improve texture and flow properties.

Garamite-7308 XR is used in drilling muds to improve rheology and prevent fluid loss.
Garamite-7308 XR is used in oil and gas production as a viscosity modifier and fluid loss control agent.

Garamite-7308 XR is used in agriculture as a soil conditioner and plant growth enhancer.
Garamite-7308 XR is used in construction as a rheology modifier in cementitious materials.
Garamite-7308 XR is used in the manufacture of ceramics to improve rheology and prevent settling of particles.



DESCRIPTION


Garamite-7308 XR is a rheology additive used in oil and solvent-based cosmetic applications.
Garamite-7308 XR is a blend of quaternium-90 sepiolite and quaternium-90 montmorillonite, which are both types of layered silicates.
The unique structure of these silicates allows them to function as thickeners and stabilizers in cosmetic formulations, improving their viscosity, texture, and stability.

Garamite-7308 XR is also known for its ability to enhance the sensory properties of cosmetics, giving them a smooth, silky feel.
Additionally, Garamite-7308 XR is compatible with a wide range of cosmetic ingredients and can be used in a variety of product types, such as lotions, creams, and gels.

Garamite-7308 XR exhibits performance benefits that cannot be achieved by traditional organoclays.
Garamite-7308 XR possesses outstanding anti-settling and anti-syneresis properties.
Garamite-7308 XR improves the spreadability and sprayability of cosmetic products.

Garamite-7308 XR is recommended for use in creams, lotions, sunscreens, antiperspirants, foundations, lipsticks and cream eye shadows.
Garamite-7308 XR is very easy to disperse with moderate shear.
Garamite-7308 XR has a shelf life of 36 months.



PROPERTIES


Appearance: white powder
Particle size: 98% < 20 microns
Bulk density: 0.30-0.45 g/cm3
pH: 6.5-7.5 (2% in water)
Moisture content: max. 10%
Solubility: insoluble in water, oils and solvents
Rheology modification: excellent thixotropic behavior and shear thinning properties
Compatibility: compatible with a wide range of oils, solvents and waxes
Stability: stable over a wide range of pH and temperature conditions
Viscosity: effective at low usage levels in achieving desired viscosity in formulations.



FIRST AID


The following are general first aid measures that can be taken in case of accidental exposure to Garamite-7308 XR:

Skin Contact:

Remove contaminated clothing and wash skin thoroughly with soap and water.
If irritation or redness develops, seek medical attention.


Eye Contact:

Rinse eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally.
Seek medical attention if irritation persists.


Inhalation:

Move to fresh air and seek medical attention if breathing becomes difficult.


Ingestion:

Rinse mouth with water and seek medical attention immediately.


It is important to note that these first aid measures are general guidelines and immediate medical attention should be sought in case of severe exposure or if symptoms persist.



HANDLING AND STORAGE


Handling:

Avoid contact with eyes, skin, and clothing.
Wear appropriate personal protective equipment, such as gloves and goggles.
Use in a well-ventilated area.
Avoid inhalation of dust or mist.


Storage:

Store in a cool, dry, and well-ventilated area.
Keep containers tightly closed when not in use.

Store away from incompatible materials, such as strong acids and oxidizing agents.
Keep away from sources of ignition, such as sparks and flames.
It is also recommended to review and follow the specific handling and storage instructions provided by the manufacturer of the product containing Garamite-7308 XR.



SYNONYMS


Quaternium-90 Sepiolite
Quaternium-90 Montmorillonite
sepiolite clay
Quaternium-90 sepiolite and quaternium-90 montmorillonite
Modified hectorite clay
Rheological additive
Viscosity modifier
Thickening agent
Gel former
Structurant
Emulsion stabilizer
Suspension agent
Flow control agent
Texture enhancer
Film-forming agent
Co-emulsifier
Conditioning agent
Opacifying agent
Anti-settling agent
Anti-sagging agent
Anti-scratch agent
Anti-blocking agent
Anti-fouling agent
GARLIC OIL
GARLIC OIL Garlic oil Garlic oil is the volatile oil derived from garlic. It is usually prepared using steam distillation, and can also be produced via distillation using ether. It is used in cooking and as a seasoning, a nutritional supplement, and also as an insecticide. Preparation Garlic oil is typically prepared using steam distillation, where crushed garlic is steamed with the resultant condensation containing the oil.[1] Garlic oil contains volatile sulfur compounds such as diallyl disulfide, a 60% constituent of the oil.[1][4][5][6] Steam-distilled garlic oil typically has a pungent and disagreeable odor and a brownish-yellow color.[5] Its odor has been attributed to the presence of diallyl disulfide.[5] To produce around 1 gram of pure steam-distilled garlic oil, around 500 grams of garlic is required.[1] Undiluted garlic oil has 900 times the strength of fresh garlic, and 200 times the strength of dehydrated garlic.[5] Ether can also be used to extract garlic oil.[1] A type of garlic oil involves soaking diced or crushed garlic in vegetable oil, but this is not pure garlic oil; rather it is a garlic-infused oil.[1] Uses Garlic oil is used as a nutritional supplement, and is sometimes marketed in the form of capsules, which may be diluted with other ingredients.[1][5] Some commercial preparations are produced with various levels of dilution, such as a preparation that contains 10% garlic oil.[5] Herbal folklore holds that garlic oil has antifungal and antibiotic properties,[2] but there is no clinical research confirming such effects. It is also sold in health food stores as a digestive aid.[7] It can also be used as an insecticide, diluted with water and sprayed on plants.[2][8] Stabilized garlic flavor blend is a proprietary mixture of dehydrated garlic powder infused with garlic oil, which increases the flavor of the garlic powder.[9] Garlic-flavored oil Garlic-flavored oil: vegetable oil infused with garlic used for seasoning Garlic-flavored oil is produced and used for cooking and seasoning purposes, and is sometimes used as an ingredient in seasoning mixtures.[1][5] This differs from essential garlic oil, and typically involves the use of chopped, macerated or crushed garlic placed in various vegetable oils to flavor the oil. See also Garlic sauce List of essential oils List of garlic dishes Theodor Wertheim – performed studies about garlic oil. Garlic, Allium sativum, is broadly used around the world for its numerous culinary and medicinal uses. Wild garlic, Allium vineale, has been used as a substitute for garlic, both in food as well as in herbal medicine. The present study investigated the chemical compositions of A. sativum and A. vineale essential oils. The essential oils from the bulbs of A. sativum, cultivated in Spain, were obtained by three different methods: laboratory hydrodistillation, industrial hydrodistillation, and industrial steam distillation. The essential oils of wild-growing A. vineale from north Alabama were obtained by hydrodistillation. The resulting essential oils were analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Both A. sativum and A. vineale oils were dominated by allyl polysulfides. There were minor quantitative differences between the A. sativum oils owing to the distillation methods employed, as well as differences from previously reported garlic oils from other geographical locations. Allium vineale oil showed a qualitative similarity to Allium ursinum essential oil. The compositions of garlic and wild garlic are consistent with their use as flavoring agents in foods as well as their uses as herbal medicines. However, quantitative differences are likely to affect the flavor and bioactivity profiles of these Allium species. Keywords: Allium sativum, Allium vineale, essential oil composition, allyl polysulfides, cluster analysis Go to: 1. Introduction Garlic (Allium sativum L., Amaryllidaceae) likely originated in Central Asia [1]. The plant has been used as a flavoring agent and a traditional medicine since antiquity, and is now cultivated worldwide [1,2]. Allium vineale L. (wild garlic, crow garlic) is native to Great Britain, most of Europe, North Africa, and the Middle East. The plant has been introduced to North America, Australia, and New Zealand [3]. Allium sativum has been used as a diaphoretic, diuretic, expectorant, and stimulant [4]. Extracts of A. sativum have shown broad-spectrum antibacterial [5] and antifungal [6] activity and the plant has been used to treat tuberculosis, coughs, and colds [7]. Garlic preparations have demonstrated hypotensive activity in moderately hypertensive subjects, and garlic-based phytotherapeutic products are used in France for minor vascular disorders [8]. There is an inverse correlation between regular consumption of garlic and stomach cancer frequency [8], but there seems to be no correlation between garlic consumption and other cancers. Garlic has been used in food preparation not only for its flavor, but also as a digestive aid [4]. Allium vineale has been used as a substitute for A. sativum in cooking; the bulb is used as a flavoring agent and the leaves as an addition to salad [9,10]. Cherokee Native Americans used both A. vineale and A. sativum as carminatives, diuretics, and expectorants [11,12]. Although there have been numerous investigations on the phytochemistry of garlic (A. sativum) [1,13,14], the chemistry of wild garlic (A. vineale) has not been investigated, and because of the history of the uses of Allium species as both condiments and phytopharmaceuticals, we have investigated the essential oil compositions of A. sativum from Spain, obtained by different isolation methods, and A. vineale growing wild in north Alabama, USA. Go to: 2. Materials and Methods 2.1. Plant Material 2.1.1. Allium sativum Bulbs of Allium sativum were collected from a field in Las Pedroñeras, Spain (39°26′59″ N, 2°40′23″ W, 745 m elevation), in December 2015. Garlic bulbs were finely chopped, and were subjected to three different distillation methods: laboratory hydrodistillation using a Clevenger apparatus for 3 h, industrial hydrodistillation for 4 h, and industrial steam distillation for 5 h. Pale yellow essential oils were obtained in 0.2%, 0.22% and 0.18% yields, respectively. The obtained essential oils and hydrosol were separated by decantation; remaining water was removed from the essential oils with sodium chloride. The collected essential oil samples were stored under refrigeration (−4 °C) until analysis. 2.1.2. Allium vineale Four different samples of Allium vineale were collected from a field in Huntsville, Alabama (34°38′46″ N, 86°33′27″ W, 191 m elevation) on 10 April 2017, 8 a.m. Each sample was cleaned of debris, the entire plant (leaves and bulbs) chopped, and hydrodistilled using a Likens-Nickerson apparatus for 4 h with continuous extraction with dichloromethane (CH2Cl2). Evaporation of the dichloromethane yielded pale yellow essential oils with an extremely pungent odor (Table 1). Table 1 Essential oil yields of Allium vineale. Sample #1 a #2 #3 #4 Mass of plant material (g) 94.04 123.29 98.20 72.35 Mass of essential oil (mg) 87.2 258.5 210.5 25.3 Essential oil yield 0.0927% 0.2097% 0.2144% 0.0350% a #1, #2, #3, and #4 are different essential oil samples. 2.2. Gas Chromatography-Mass Spectrometry (GC-MS) GC-MS characterization of A. sativum oils was carried out as previously described using a Shimadzu GCMS-QP2010 Ultra (Shimadzu Scientific Instruments, Columbia, MD, USA) [15,16]. This instrument was operated in the electron impact (EI) mode set at electron energy 70 eV with a scan range of 40–400 amu, a scan rate of 3.0 scans per second, and with GC-MS solution software. A ZB-5 fused silica capillary column (Phenomenex, Torrance, CA, USA), 30 m length × 0.25 mm inner diameter, with a (5% phenyl)-polymethylsiloxane stationary phase and a film thickness of 0.25 μm was used as the GC column. Helium was used as the carrier gas and the pressure was set at 551.6 kPa with a flow rate of 1.37 mL/min on the column head. The temperature of the injector was set at 250 °C and the temperature of the ion source was set at 200 °C. The temperature of the GC oven was programmed to be 50 °C initially and was programmed to increase at a rate of 2 °C/min to a final temperature of 260 °C. The samples were prepared with CH2Cl2 in a 5% w/v solution. Then, 0.1 µL of the solutions were injected into the instrument with a split ratio of 30:1. GC-MS analysis of A. vineale oils was carried out as previously described [17]: Agilent 6890 GC (Agilent Technologies, Santa Clara, CA, USA), Agilent 5973 mass selective detector (Agilent Technologies), EI mode (70 eV), 40–400 mass scan range, 3.99 scans/s scan rate, and operated through an Agilent ChemStation data system (G1701CA, Agilent Technologies); HP-5ms capillary column (30 m length × 0.25 mm inner diameter × 0.25 μm film thickness), helium carrier gas, head pressure (92.4 kPa), flow rate (1.5 mL/min); oven temperature program (60 °C initial temperature, which was held for 5 min, temperature increased at a rate of 3 °C/min up to 280 °C), inlet temperature (250 °C), interface temperature (280 °C). Allium vineale solutions (1 μL of 1% in CH2Cl2) were injected using a splitless mode. The retention indices were determined by reference to a homologous series of n-alkanes. The components of each essential oil sample were identified based on their retention indices and mass spectral fragmentation patterns compared to reference literature [18,19,20,21,22] and our in-house library. 2.3. Semi-Quantitative Gas Chromatography Semi-quantitative GC was performed with an Agilent 6890 GC with Agilent FID (flame ionization detector) (Agilent Technologies), HP-5ms column (30 m length × 0.25 mm inner diameter × 0.25 μm film thickness), He carrier gas, head pressure (144.1 kPa), flow rate (2.0 mL/min); oven temperature program (as above). The percent compositions of the essential oils were determined from raw peak area percentages without standardization. 2.4. Hierarchical Cluster Analysis The chemical compositions of A. sativum from this current study along with garlic oil compositions from previously published works (hydrodistillations and steam distillations only) [6,23,24,25,26,27,28,29,30] were used as operational taxonomic units (OTUs). The percentages of the major sulfur-containing compounds (diallyl sulfide, allyl methyl disulfide, dimethyl trisulfide, diallyl disulfide, allyl (Z)-1-propenyl disulfide, allyl (E)-1-propenyl disulfide, allyl methyl trisulfide, 2-vinyl-4H-1,3-dithiine, diallyl trisulfide, and diallyl tetrasulfide) were used to evaluate the chemical similarities and differences between the garlic oil samples by agglomerative hierarchical cluster (AHC) analysis using the XLSTAT software, version 2015.4.01 (Addinsoft™, New York, NY, USA). Pearson correlation was used to evaluate similarity and clusters were defined by the unweighted pair-group method with arithmetic averaging (UPGMA). The oil compositions from this study show quantitative similarities and differences from previously published reports on garlic oil [6,23,24,25,26,27,28,29,30]. Egyptian garlic essential oil extracted by hydrodistillation had diallyl disulfide (25.2%), allyl methyl trisulfide (23.8%) and diallyl trisulfide (21.1%) as the major constituents [29]. The major components of Serbian garlic essential oil obtained by hydrodistillation were diallyl trisulfide (33.6%), diallyl disulfide (28.1%), and allyl methyl trisulfide (17.8%) [26]. Diallyl disulfide (49.1%) and diallyl trisulfide (30.4%) were the main components of Tunisian garlic essential oil obtained by hydrodistillation [31]. The profile identified in this study was also different from French garlic oil presented by Mnayer et al. [27] in which the major components were diallyl disulfide (37.9%), diallyl trisulfide (28.1%), allyl methyl trisulfide (7.3%), diallyl sulfide (6.6%), diallyl tetrasulfide (4.1%) and allyl methyl disulfide (3.7%). Douiri et al. [23] showed that A. sativum essential oil obtained by Clevenger hydrodistillation was dominated by diallyl trisulfide (46.5%) followed by diallyl disulfide (16.0%), allyl methyl trisulfide (10.9%) and diallyl disulfide (7.2%). Similarly, Rao and co-workers have analyzed six geographical varieties of essential oils obtained by steam distillation of fresh garlic grown in India. These investigators found diallyl disulfide (27.1–46.8%) and diallyl trisulfide (19.9–34.1%) to be the dominant components, followed by allyl methyl trisulfide (8.3–18.2%), and allyl methyl disulfide (4.4–12.0%) [28]. Commercial Chinese garlic oil has shown abundant diallyl disulfide (45.1–63.2%), diallyl trisulfide (18.5–23.4%), diallyl sulfide (4.5–11.4%), and diallyl tetrasulfide (6.3–10.5%) (unpublished results from our laboratories). Kimbaris and co-workers obtained garlic oil from Greece (Likens-Nickerson hydrodistillation-extraction) and found diallyl disulfide (23.1–28.4%), diallyl trisulfide (18.2–22.1%), allyl methyl trisulfide (16.3–17.5%), and allyl methyl disulfide (8.5–11.2%) The essential oils of garlic and wild garlic are shown to be dominated by sulfur-containing compounds, particularly allyl polysulfides. Garlic oils from various geographical locations have shown qualitative similarities, but quantitative differences in the concentrations of organosulfur compounds, and are likely to affect both the medicinal and the organoleptic properties of the garlic. Wild garlic is qualitatively similar in composition to garlic, but there are some key differences: diallyl disulfide and diallyl trisulfide concentrations are higher in garlic than in wild garlic, while allyl 1-propenyl disulfide and dimethyl trisulfide concentrations are higher in wild garlic than in garlic. Allium sativum is one of the medicinal herbs placed in the family Alliaceae1. The important chemical constituents reported from Bulbus Allii Sativi are the sulfur compounds. The allicin, ajoenes and sulfides (e.g. diallyl disulfide, diallyl trisulfide), are not naturally occurring compounds. They are formed by naturally occurring alliin. When the garlic bulb is crushed, alliin is released and interacts with the enzyme alliinase to forms allicin.2,3 Allicin itself is an unstable product and undergo additional reactions to form different derivatives, depending on environmental conditions.4 Due to presence of compounds such as, sulfur's compounds, lipids, complex of fructosans, etheric oil, cellulose, minerals (Mg, Zn, Se, germanium), vitamins (C, A, from B complex), enzymes, amino acids, etc., it is particularly important in medicine.5 The presence of above chemicals in Garlic helps to inhibit bacteria, fungi, parasites. Cooked garlic or various aged extracts and oils can in some cases provide better protection against infection than raw garlic.6 Garlic extracts exhibited activity against gram negative (E. coli, Enterobacter, Pseudomonas, Kilabsella) and gram positive (S.aureus, S. Pneumonia, Group A Streptococcus and Bacillus anthrax). Molecular Weight of Garlic oil: 488.9 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Hydrogen Bond Donor Count of Garlic oil: 0 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Hydrogen Bond Acceptor Count of Garlic oil: 8 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Rotatable Bond Count of Garlic oil: 16 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Exact Mass of Garlic oil: 488.049814 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Monoisotopic Mass of Garlic oil: 488.049814 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Topological Polar Surface Area of Garlic oil: 188 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Heavy Atom Count of Garlic oil: 26 Computed by PubChem Formal Charge of Garlic oil: 0 Computed by PubChem Complexity of Garlic oil: 243 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Isotope Atom Count of Garlic oil: 0 Computed by PubChem Defined Atom Stereocenter Count of Garlic oil: 0 Computed by PubChem Undefined Atom Stereocenter Count of Garlic oil: 1 Computed by PubChem Defined Bond Stereocenter Count of Garlic oil: 0 Computed by PubChem Undefined Bond Stereocenter Count of Garlic oil: 0 Computed by PubChem Covalently-Bonded Unit Count of Garlic oil: 3 Computed by PubChem Compound of Garlic oil Is Canonicalized Yes
GDL (Glukono Delta Lakton)
Synonyms: -Phosphoguanylyl-(3';TELEOSTEAN GELATIN;PRIONEX(R) GELATIN;absorbablegelatinsponge;Galfoam;gelatinfoam;gelfoam;BLOOM 300 CAS: 9000-70-8
Gelatin
gt;Galfoam;gelfoam;GELATIN;Gelfilm;Spongel;puragel;GELATINA;GELATINE;gelatins CAS NO: 9000-70-8
GIBBSITE
Gibbsite occurs as a mineral in nature in three much rarer polymorphs: bayerite, doyleite and nordstrandite.
Gibbsite is amphoteric, i.e., Gibbsite has both basic and acidic properties.
Gibbsite is a halogen-free, environmentally friendly flame retardant and smoke suppressant filler for plastics and rubber.

CAS Number: 21645-51-2
EC Number: 244-492-7
Chemical Formula: Al(OH)3
Molar Mass: 78.003 g·mol−1

Aluminium trihydrate, Aluminum, trihydrate, DTXSID20421935, MXRIRQGCELJRSN-UHFFFAOYSA-N, aluminum;trihydroxide, Dried aluminum hydroxide gel, Aluminium hydroxide gel, dried, aluminium trihydroxide, aluminum hyroxide, Hydroxyde d' aluminium, Dried aluminium hydroxide, Aluminium hydroxide, dried, Aluminum hydroxide gel, dried, CHEMBL1200706, DTXSID2036405, NIOSH/BD0708000, Di-mu-hydroxytetrahydroxydialuminum, AF-260, AKOS015904617, Aluminum, di-mu-hydroxytetrahydroxydi-, DB06723, BD07080000, Aluminium trihydrate [ACD/IUPAC Name], Aluminium, trihydrate [French] [ACD/IUPAC Name], Aluminiumtrihydrat [German] [ACD/IUPAC Name], 106152-09-4 [RN], 12252-70-9 [RN], 128083-27-2 [RN], 1302-29-0 [RN], 13783-16-9 [RN], 14762-49-3 [RN], 151393-94-1 [RN], 159704-77-5 [RN], 21645-51-2 [RN], 51330-22-4 [RN], 8012-63-3 [RN], 8064-00-4 [RN], AC 714KC, AKP-DA, Al(OH)3, Alcoa A 325, Alcoa AS 301, Alcoa C 30BF, Alcoa C 31, Alcoa C 33, Alcoa C 330, Alcoa C 331, Alcoa C 333, Alcoa C 385, Alcoa H 65, Alhydrogel [Wiki], Alolt 8, ALterna GEL [Trade name], ALternaGEL, Alu-Cap, Alugel, Alugelibye, Alumigel, Alumina trihydrate, Aluminic acid (H3AlO3), Aluminium hydroxide [Wiki], aluminium(3+) hydroxide, aluminium(III) hydroxide, Aluminiumhydroxid, ALUMINUM HYDROXIDE [USP], Aluminum hydroxide (Al(OH)3), Aluminum Hydroxide Gel, Aluminum hydroxide, dried [JAN], Aluminum oxide trihydrate, Aluminum trihydroxide, Aluminum(III) hydroxide, Alusal, Amberol ST 140F, Amorphous alumina, Amphogel, Amphojel, Antipollon HT, Apyral, Apyral 120, Apyral 120VAW, Apyral 15, Apyral 2, Apyral 24, Apyral 25, Apyral 4, Apyral 40, Apyral 60, Apyral 8, Apyral 90, Apyral B, Arthritis Pain Formula Maximum Strength, Ascriptin, BACO AF 260, Boehmite, British aluminum AF 260, C 31C, C 31F, C 4D, C-31-F, Calcitrel, Calmogastrin, Camalox, Dialume [Trade name], Di-Gel Liquid, Gelusil, Gibbsite (Al(OH)3), Higilite, Higilite H 31S, Higilite H 32, Higilite H 42, Hychol 705, Hydrafil, Hydral 705, Hydral 710, Hydrated Alumina, Hydrated aluminum oxide, Kudrox, Liquigel, Maalox [Wiki], Maalox HRF, Maalox Plus, Martinal, Martinal A, Martinal A/S, Martinal F-A, Mylanta [Wiki], P 30BF, Reheis F 1000, Simeco Suspension, Tricreamalate, Trihydrated alumina, trihydroxidoaluminium, Trihydroxyaluminum, Trisogel, WinGel

Gibbsite is initially derived from bauxite ore, before being refined into a fine white powder.
Gibbsite (also known as ATH and aluminium trihydroxide, chemical formula Al (OH)3) is initially derived from bauxite ore, before being refined into a fine white powder.

Annual production of Gibbsite is around 100 million tons which is nearly all produced through the Bayer process.
The Bayer process dissolves bauxite (Aluminium Ore) in sodium hydroxide at elevated temperatures.

Gibbsite is then separated from the solids that remain after the heating process.
The solids remaining after the Gibbsite is removed is highly toxic and presents environmental issues.

Gibbsite are available in different uncoated and coated grades, with average particle size varying from 2 microns to 80 microns as per application.
Gibbsite is a common primary ingredient present in most solid surface material and accounts for as much as 70% of the total product.

Gibbsite is used as a filler for epoxy, urethane, or polyester resins, where fire retardant properties or increased thermal conductivity are required.
Gibbsite is white in color.

Gibbsite is a flame retardant and smoke suppressant.
Gibbsite thermodynamic properties, endothermic dehydration cools the plastic 6 rubber parts and dilutes the combustible gases with water vapours that is generated in case of fire.

Gibbsite is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.
Gibbsite is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Gibbsite is a halogen-free, environmentally friendly flame retardant and smoke suppressant filler for plastics and rubber.
Gibbsite is suitable for a broad range of applications including solid surface, composites and electrical insulation.

Gibbsite is a white, translucent powder that is also called aluminum hydroxide.
Gibbsite is obtained from Bauxite.

When Gibbsite is strongly heated, Gibbsite will convert to Aluminum oxide with the release of water.
Gibbsite is used as a base in the preparation of transparent lake pigments.

Gibbsite is also used as an inert filler in paints and tends to increase the transparency of colors when dispersed in oils.
Gibbsite is used commercially as a paper coating, flame retardant, water repellant, and as a filler in glass, ceramics, inks, detergents, cosmetics, and plastics.

Gibbsite occurs as a mineral in nature in three much rarer polymorphs: bayerite, doyleite and nordstrandite.
Gibbsite is amphoteric, i.e., Gibbsite has both basic and acidic properties.

Closely related are aluminium oxide hydroxide, AlO(OH), and aluminium oxide or alumina (Al2O3), the latter of which is also amphoteric.
These compounds together are the major components of the aluminium ore bauxite.
Gibbsite also forms a gelatinous precipitate in water.

Gibbsite is a non-halogen fire retardant and smoke suppressant.
Gibbsite is a major mineral fire retardant being the largest selling fire retardant additive in the world.

Gibbsite is used commercially as a paper coating, flame retardant, water repellant, and as a filler in glass, ceramics, inks, detergents, cosmetics, and plastics.
When strongly heated, Gibbsite decomposes into aluminium oxide with release of water following an endothermic reaction.

Gibbsite (ATH or hydrated alumina) is a non-toxic, non-corrosive, flame retardant and smoke suppressant utilized in elastomeric applications.
Gibbsite is the most frequently used flame retardant in the world.

Gibbsite is a very effective flame retardant due to Gibbsite thermodynamic properties which absorb heat and release water vapor.
Gibbsite releases its 35% water of crystallization as water vapor when heated above 205°C.

The resulting endothermic reaction cools Gibbsite below flash point, reducing the risk of fire and acts as a vapor barrier to prevent oxygen from reaching the flame.
Typical loadings vary from 20 phr to 150 phr.
Because many polymers like polyethylene and polypropylene process above 200°C, these polyolefins should use magnesium hydroxide as a flame retardant filler since Gibbsite water of hydration releases at approximately 325°C.

Gibbsites are obtained by digestion of bauxite throughout the Bayer process.

Gibbsite starts to remove constitution water above 180°C
Water removal cools the surface and eliminates entry of oxygen, which confers flame retardant properties and smoke suppressant.
Accordingly Gibbsite is a necessary raw material for products like rubber, polyurethane, polyester, silicone, thermoplastic, cables, etc. with fire retardant properties.

Gibbsite has a number of common names used throughout the chemical industry which include: Hydrate Alumina, Alumina Hydrate, Aluminium Tri Hydroxide, ATH, Aluminium Hydrate and Aluminium Hydroxide.

Gibbsite is a white, odorless, powdery, solid substance.
Gibbsite demonstrates a very low solubility in water but is considered to be amphoteric, meaning Gibbsite will dissolve in both acids or a strong alkali.

The most common use of Gibbsite is for the production of aluminum metal.
Gibbsite is also used as a flame retardant and smoke suppressant filler in polymers such as rubber products and carpet backing.

Gibbsite is a white filling material that provides flame retardant and self-extinguishing properties for polyester resins and gelcoats.
Gibbsite exposes water molecules within the body at high temperatures to reduce flame spread and smoke formation.
Gibbsite is used in GRP pipe applications, in acrylic applications and in other multicomponent applications.

Aluminum trihydrate (also known as aluminum hydrate, alumina hydrate, aluminum hydroxide, or ATH) is a filler, extender pigment, and bodying agent in oil- and water-borne paint that does not greatly affect the color of the paint.
This is an 8-micron median particle size extender that is a white to tan colored powder and can be added to paint to impart transparency to the paint film.

Gibbsite is the most widely used flame retardant in commercial coatings due to Gibbsite versatility and low cost.
Gibbsite can be used in a wide range of paint binders at processing temperatures below 220°C.

Gibbsite is non-toxic, halogen-free, chemically inert, and has low abrasiveness.
Additional benefits are acid resistance and smoke suppression.

At about 220°C, Gibbsite begins to decompose endothermically releasing approximately 35% of Gibbsite weight as water vapor.

AI2O3•3H2O + HEAT —–> AI2O3 + 3 H2O

Gibbsite acts as a heat sink thereby retarding pyrolysis and reducing the burning rate.
The water vapor released has an added effect of diluting combustion gases and toxic fumes.

Gibbsite is the hydrated oxide of aluminium.
Aluminium hydrate is separated from bauxite ore using the Bayer process, with average particle size ranging from 80-100 micron.

The block crystals of alumina hydrate impart good chemical reactivity.
Alumina hydrate can react with a base as well as an acid, and finds use in many applications as raw material.

After drying, alumina hydrate is ground using mechanical mills and ceramic lined ball mills to obtain finer particle sizes.
Hindalco manufactures ground hydrate with different particle size (5-15 micron) distribution.
Surface-treated fine hydrate as well as super-ground fine hydrate (1-2.5 micron) are also available.

Gibbsite obtained in the Bayer process, is calcined at temperature above 1200°C and up to 1600°C to manufacture special grade alumina.
During calcinations, alumina hydrate crystals lose bound moisture and recrystallise to form alumina crystals.

The particle size of alumina remains at 85-100 micron.
Special alumina contains predominantly alpha phase.
The degree of calcination is a measure of the hardness of alumina – soft to hard.

Coarse alumina is classified based on the soda (Na2O) content:
Low soda alumina - Na2O <0.1%
Medium soda alumina - 0.1% < Na2O <0.2%
Normal Soda alumina - 0.20% < Na2O < 0.45%

Calcined alumina is ground in fluid energy mills or ceramic lined ball mills to meet the desired particle size required by the customers.
Hindalco manufactures fine alumina with varying particle size (0.5 to 8 micron) and distribution.
Low soda, medium soda and normal soda type are available in fine alumina also.

The global Gibbsite market size was valued at USD 1.5 billion in 2020 and is projected to reach USD 1.9 billion by 2025, growing at a cagr 5.5% from 2020 to 2025.
The major drivers for the market include the rising consumer demand for Gibbsite in different applications and enduse industries, such as flame retardants, and paints & coatings.
However, the substitutes present in the market, for instance, magnesium hydroxide, can restrain the market growth.

Covid-19 Impact On The Global Gibbsite Market:
The global Gibbsite market is expected to witness a moderate decrease in Gibbsite growth rate in 2020-2021, as the Gibbsite industry witness a significant decline in Gibbsite production.
Gibbsite has affected the market for Gibbsite manufacturers catering to the glass and rubber industries, which were not considered essential.

Moreover, most of the global companies operating in this market are based in Asia Pacific, the US, and European countries, which are adversely affected by the pandemic.
These companies having their manufacturing units in China and other Asian countries are also severely affected.
Therefore, disruptions in the supply chain have resulted in hampering production units due to a lack of raw materials and workforce.

Gibbsite Market Dynamics:

Driver: Increasing demand for non-halogenated flame retardants:
The growing number of residential and commercial establishments has increased the possibilities of explosions and fire-related accidents.
Therefore, several countries across North America and Europe have mandated stringent fire safety regulations and protocols.

This has led to the increased use of flame retardants in buildings to meet these government regulations.
The major application of flame retardants is in electric wire insulation in building & construction, and transportation.

Flame retardants are used in circuit boards, electronic casing, and cables & wire systems.
Stringent fire safety standards to reduce the spread of fires in residential and commercial buildings are driving the demand for halogen-free flame retardants.

Opportunities:
Use of Gibbsite in water treatment plants Gibbsite (alum) is the most common coagulant used in water and wastewater treatment.
The main purpose of using alum in these applications is to improve the settling of suspended solids and color removal.

Alum is also used to remove phosphate from wastewater treatment effluent.
Thus, the growing urbanization in emerging economies, such as China and India, is expected to fuel the demand for water treatment plants in residential areas.

Nevertheless, many people still lack access to safe water and suffer from preventable water-borne microbial diseases leading to the increased demand for wastewater treatment plants.
Thus, the use of aluminum hydroxide in water treatment plants in residential areas is expected to act as an opportunity for the growth of the Gibbsite market across the globe.

Challenges:

Environmental issues related to alumina production:
Alumina production leads to bauxite residue, also known as red mud.
The disposal of bauxite residue/red mud is a challenge due to relatively large volumes, occupying land areas, and the alkalinity of the residue and the run-off water.

Only a very small proportion of the bauxite residue produced are re-used in any way.
Although the residue has a number of characteristics of environmental concern, the most immediate and apparent barrier to remediation and utilization is Gibbsite high alkalinity and sodicity.

The high pH of the bauxite residue is a problem from both a health and safety point-of-view.
This can pose a challenge for the Gibbsite market.

Applications of Gibbsite:
Over 90% of all Gibbsite produced is converted to Aluminium Oxide (alumina) that is used to manufacture aluminum.
As a flame retardant, Gibbsite is chemically added to a polymer molecule or blended in with a polymer to suppress and reduce the spreading of a flame through a plastic.
Gibbsite is also used as an antacid that can be ingested in order to buffer the pH within the stomach.

Gibbsite is the hydrated oxide of aluminium.
Gibbsite is separated from ore bauxite using Bayer process with average particle size ranging from 80-100 micron.

The blocky crystals of Gibbsite impart good reactivity.
Gibbsite can react with a base as well as an acid and finds many applications as raw material.

Gibbsite is used in the manufacture of many inorganic chemicals like:
Non- ferric alum
Poly aluminium chloride
Aluminium fluoride
Sodium aluminate
Catalysts
Glass
Gibbsite gel
Alumina hydrate is available in wet as well as dry form.

Fine hydrate:
Gibbsite contain 3 molecules of water.
On exposure to heat above 220°C, alumina hydrate decomposes into aluminium oxide (alumina) and water.

This irreversible, endothermic reaction process makes alumina hydrate an effective flame retardant.
Also, the smoke generated by decomposition is non-corrosive and non-poisonous.
Ground alumina hydrate is used as fire retardant filler in applications like polymer composites, cable compounds, solid surface counter tops, etc.

Uses of Gibbsite:
Of the Common fillers used in Plastics, Rubber, FRP, SMC, DMC moulding and other polymers only Gibbsite has flame retarding and smoke suppressing properties as well as being an economical resin extender.

Gibbsite is used in polyester resins.
However with increased attention being given to smoke & toxic fume emissions, Gibbsite has found large volume application in vinyl as a low smoke, non toxic replacement for antimony and in polyurethane, latex, neoprene foam system, Rubber, wire & Cable insulation, vinyl walls & flooring coverings and epoxies.

Gibbsite acts as a flame retardant and smoke suppressor because of Gibbsite thermodynamic properties.
Gibbsite endothermic dehydration cools the plastic & Rubber parts and dilute with water vapour those combustible gases that do escape.
The latter is probably the main phenomenon associated with smoke suppression other excellent performance include electrical and track resistance.

Gibbsite widely use in Paper Industries as a whitening agent in place of titanium dioxide.

Gibbsite is also use in Paints Industries.
Gibbsite can replace upto 25% of the Titanium dioxide pigment & therefore is an economical extender reducing production cost.

Fire retardant filler:
Gibbsite also finds use as a fire retardant filler for polymer applications.
Gibbsite is selected for these applications because Gibbsite is colorless (like most polymers), inexpensive, and has good fire retardant properties.

Magnesium hydroxide and mixtures of huntite and hydromagnesite are used similarly.
Gibbsite decomposes at about 180 °C (356 °F), absorbing a considerable amount of heat in the process and giving off water vapour.
In addition to behaving as a fire retardant, Gibbsite is very effective as a smoke suppressant in a wide range of polymers, most especially in polyesters, acrylics, ethylene vinyl acetate, epoxies, polyvinyl chloride (PVC) and rubber.

Precursor to Al compounds:
Gibbsite is a feedstock for the manufacture of other aluminium compounds: calcined aluminas, aluminium sulfate, polyaluminium chloride, aluminium chloride, zeolites, sodium aluminate, activated alumina, and aluminium nitrate.

Freshly precipitated Gibbsite forms gels, which are the basis for the application of aluminium salts as flocculants in water purification.
This gel crystallizes with time.

Gibbsite gels can be dehydrated (e.g. using water-miscible non-aqueous solvents like ethanol) to form an amorphous Gibbsite powder, which is readily soluble in acids.
Heating converts Gibbsite to activated aluminas, which are used as desiccants, adsorbent in gas purification, and catalyst supports.

Pharmaceutical:
Under the generic name "algeldrate", Gibbsite is used as an antacid in humans and animals (mainly cats and dogs).
Gibbsite is preferred over other alternatives such as sodium bicarbonate because Al(OH)3, being insoluble, does not increase the pH of stomach above 7 and hence, does not trigger secretion of excess acid by the stomach.

Brand names include Alu-Cap, Aludrox, Gaviscon or Pepsamar.
Gibbsite reacts with excess acid in the stomach, reducing the acidity of the stomach content, which may relieve the symptoms of ulcers, heartburn or dyspepsia.

Such products can cause constipation, because the aluminium ions inhibit the contractions of smooth muscle cells in the gastrointestinal tract, slowing peristalsis and lengthening the time needed for stool to pass through the colon.
Some such products are formulated to minimize such effects through the inclusion of equal concentrations of magnesium hydroxide or magnesium carbonate, which have counterbalancing laxative effects.

Gibbsite is also used to control hyperphosphatemia (elevated phosphate, or phosphorus, levels in the blood) in people and animals suffering from kidney failure.
Normally, the kidneys filter excess phosphate out from the blood, but kidney failure can cause phosphate to accumulate.
The aluminium salt, when ingested, binds to phosphate in the intestines and reduce the amount of phosphorus that can be absorbed.

Precipitated Gibbsite is included as an adjuvant in some vaccines (e.g. anthrax vaccine).
One of the well-known brands of Gibbsite adjuvant is Alhydrogel, made by Brenntag Biosector.

Since Gibbsite absorbs protein well, Gibbsite also functions to stabilize vaccines by preventing the proteins in the vaccine from precipitating or sticking to the walls of the container during storage.
Gibbsite is sometimes called "alum", a term generally reserved for one of several sulfates.

Vaccine formulations containing Gibbsite stimulate the immune system by inducing the release of uric acid, an immunological danger signal.
This strongly attracts certain types of monocytes which differentiate into dendritic cells.

The dendritic cells pick up the antigen, carry Gibbsite to lymph nodes, and stimulate T cells and B cells.
Gibbsite appears to contribute to induction of a good Th2 response, so is useful for immunizing against pathogens that are blocked by antibodies.
However, Gibbsite has little capacity to stimulate cellular (Th1) immune responses, important for protection against many pathogens, nor is Gibbsite useful when the antigen is peptide-based.

Gibbsite is used in various industries as:
Gibbsite is used as a raw material in the production of Aluminium chemicals
Gibbsite is used as a raw material in the manufacture of glass and glazes

Gibbsite is used as a raw material in catalyst production
Gibbsite is used as a flame retardant and smoke suppressant filler in plastics (for example: Cables, rubber products and carpet backing)

Gibbsite is used as a raw material for fertilizers, and fiber cement board products
Gibbsite is used as an extender and a bodying agent in paper, solvent- and water-borne paints, UV-curable coatings, inks, and adhesives

Gibbsite is used as a polishing and cleansing agent Mould wash and separating agent
Gibbsite is used as a filler of cast polymer products such as onyx and solid surfaces

Uses at industrial sites:
Gibbsite is used in the following products: coating products, fillers, putties, plasters, modelling clay, polymers and washing & cleaning products.
Gibbsite has an industrial use resulting in manufacture of another substance (use of intermediates).

Gibbsite is used in the following areas: mining, building & construction work and formulation of mixtures and/or re-packaging.
Gibbsite is used for the manufacture of: chemicals, furniture, plastic products and rubber products.

Release to the environment of Gibbsite can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures, manufacturing of Gibbsite and in processing aids at industrial sites.
Other release to the environment of Gibbsite is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

Consumer Uses:
Gibbsite is used in the following products: cosmetics and personal care products, coating products, inks and toners, fillers, putties, plasters, modelling clay, pharmaceuticals, adhesives and sealants, washing & cleaning products, lubricants and greases and polishes and waxes.
Release to the environment of Gibbsite can occur from industrial use: formulation of mixtures and formulation in materials.
Other release to the environment of Gibbsite is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Widespread uses by professional workers:
Gibbsite is used in the following products: inks and toners, coating products, fillers, putties, plasters, modelling clay, washing & cleaning products, adhesives and sealants, cosmetics and personal care products, lubricants and greases and polishes and waxes.
Gibbsite is used in the following areas: building & construction work, printing and recorded media reproduction, formulation of mixtures and/or re-packaging and agriculture, forestry and fishing.

Gibbsite is used for the manufacture of: textile, leather or fur and wood and wood products.
Other release to the environment of Gibbsite is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Gibbsite is characterised by:
High purity
High whiteness
Relatively low density (2.4g/cm3) compared to other mineral fillers (typically 2.7g/cm3)
Medium Mohs hardness of 3
Decomposition around 180oC, releasing water (making Gibbsite an excellent halogen-free flame retardant)

Properties of Gibbsite:
Gibbsite is amphoteric.
In acid, Gibbsite acts as a Brønsted–Lowry base.

Gibbsite neutralizes the acid, yielding a salt:
3 HCl + Al(OH)3 → AlCl3 + 3 H2O

In bases, Gibbsite acts as a Lewis acid by binding hydroxide ions:
Al(OH)3 + OH− → [Al(OH)4]−

Physical Properties:
Powdery substance
Odorless
Non-carcinogenic
Gibbsite adds thermal properties that provide translucency and whiteness
Solid surface material
Non-smoking
Low-toxicity
Halogen-free
Flame retardant

Performance Benefits of Gibbsite:
Flame retardant / smoke suppressant
Ultra-white / translucent
High purity – blush resistance
Faster gel time
Low viscosity / higher loadings
Higher mechanical properties

Production of Gibbsite:
Virtually all the Gibbsite used commercially is manufactured by the Bayer process which involves dissolving bauxite in sodium hydroxide at temperatures up to 270 °C (518 °F).
The waste solid, bauxite tailings, is removed and Gibbsite is precipitated from the remaining solution of sodium aluminate.
This Gibbsite can be converted to aluminium oxide or alumina by calcination.

The residue or bauxite tailings, which is mostly iron oxide, is highly caustic due to residual sodium hydroxide.
Gibbsite was historically stored in lagoons; this led to the Ajka alumina plant accident in 2010 in Hungary, where a dam bursting led to the drowning of nine people.
An additional 122 sought treatment for chemical burns.

The mud contaminated 40 square kilometres (15 sq mi) of land and reached the Danube.
While the mud was considered non-toxic due to low levels of heavy metals, the associated slurry had a pH of 13.

Structure of Gibbsite:
Al(OH)3 is built up of double layers of hydroxyl groups with aluminium ions occupying two-thirds of the octahedral holes between the two layers.
Four polymorphs are recognized.

All feature layers of octahedral Gibbsite units, with hydrogen bonds between the layers.
The polymorphs differ in terms of the stacking of the layers.

All forms of Al(OH)3 crystals are hexagonal:
Gibbsite is also known as γ-Al(OH)3 or α-Al(OH)3
Bayerite is also known as α-Al(OH)3 or β-Gibbsite
Nordstrandite is also known as Al(OH)3
Doyleite

Aluminium trihydrate, once thought to be Gibbsite, is an aluminium phosphate.
Nonetheless, both gibbsite and Aluminium trihydrate refer to the same polymorphism of Hydrargillite, with gibbsite used most commonly in the United States and Gibbsite used more often in Europe.
Gibbsite is named after the Greek words for water (hydra) and clay (argylles).

Safety of Gibbsite:
In the 1960s and 1970s Gibbsite was speculated that aluminium was related to various neurological disorders, including Alzheimer's disease.
Since then, multiple epidemiological studies have found no connection between exposure to environmental or swallowed aluminium and neurological disorders, though injected aluminium was not looked at in these studies.

Neural disorders were found in experiments on mice motivated by Gulf War illness (GWI).
Gibbsite injected in doses equivalent to those administered to the United States military, showed increased reactive astrocytes, increased apoptosis of motor neurons and microglial proliferation within the spinal cord and cortex.

Identifiers of Gibbsite:
CAS Number: 21645-51-2
ChEBI: CHEBI:33130
ChEMBL: ChEMBL1200706
ChemSpider: 8351587
DrugBank: DB06723
ECHA InfoCard: 100.040.433
KEGG: D02416
PubChem CID: 10176082
RTECS number: BD0940000
UNII: 5QB0T2IUN0
CompTox Dashboard (EPA): DTXSID2036405
InChI: InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
Key: WNROFYMDJYEPJX-UHFFFAOYSA-K
A02AB02 (WHO) (algeldrate)
InChI=1/Al.3H2O/h;3*1H2/q+3;;;/p-3
Key: WNROFYMDJYEPJX-DFZHHIFOAJ
SMILES: [OH-].[OH-].[OH-].[Al+3]

CAS number: 21645-51-2
EC number: 244-492-7
Hill Formula: AlH₃O₃
Chemical formula: Al(OH)₃ * x H₂O
Molar Mass: 78 g/mol
HS Code: 2818 30 00
Quality Level: MQ200

Properties of Gibbsite:
Chemical formula: Al(OH)3
Molar mass: 78.003 g·mol−1
Appearance: White amorphous powder
Density: 2.42 g/cm3, solid
Melting point: 300 °C (572 °F; 573 K)
Solubility in water: 0.0001 g/(100 mL)
Solubility product (Ksp): 3×10−34
Solubility: soluble in acids and alkalis
Acidity (pKa): >7
Isoelectric point: 7.7

Density: 2.42 g/cm3 (20 °C)
Melting Point: 300 °C Elimination of water of crystallisation
pH value: 8 - 9 (100 g/l, H₂O, 20 °C) (slurry)
Vapor pressure:
Molecular Weight: 81.028 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 0
Exact Mass: 81.0132325 g/mol
Monoisotopic Mass: 81.0132325 g/mol
Topological Polar Surface Area: 3Ų
Heavy Atom Count: 4
Complexity: 0
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 4
Compound Is Canonicalized: Yes

Thermochemistry of Gibbsite:
Std enthalpy of formation (ΔfH⦵298): −1277 kJ·mol−1

Specifications of Gibbsite:
Identity: conforms
Chloride (Cl): ≤ 0.01 %
Sulfate (SO₄): ≤ 0.05 %
Fe (Iron): ≤ 0.01 %
Na (Sodium): ≤ 0.3 %
Loss on ignition (700 °C): 30.0 - 35.0 %
Bulk density: about 90
Particle size (< 150 µm): about 90

Related compounds of Gibbsite:
Boric acid
Gallium(III) hydroxide
Indium(III) hydroxide
Thallium(III) hydroxide
Scandium(III) hydroxide
Sodium oxide
Aluminium oxide hydroxide

Names of Gibbsite:

Regulatory process names:
Aluminium hydroxide
aluminium hydroxide
Aluminum hydroxide, dried

IUPAC names:
Alumina hydrate
ALUMINA TRIHYDRATE
Alumina trihydrate
ALUMINIUM HYDROXIDE
Aluminium Hydroxide
Aluminium hydroxide
aluminium hydroxide
Aluminium Hydroxide
Aluminium hydroxide
aluminium hydroxide
Aluminium hydroxide, Alumina hydrate
Aluminium hydroxide_JS
Aluminium hydroxyde
aluminium trihydrate
Aluminium trihydrate
Aluminium trihydroxide
aluminium trihydroxide
aluminium(3+) ion trihydroxide
Aluminium(3+) trihydroxide
aluminium(3+) trihydroxide
aluminium(III) hydroxide
Aluminiumhydroxid
aluminuim hydroxide
ALUMINUM HYDROXIDE
Aluminum Hydroxide
Aluminum hydroxide
aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide (Al(OH)3)
Aluminum hydroxide (Al(OH)3)
Aluminum Trihydrate
Aluminum trihydrate
aluminum trihydrate
Aluminum trihydroxide
aluminum trihydroxide
ATH
Hydrate
Sulcabai

Preferred IUPAC name:
Aluminium hydroxide

Systematic IUPAC name:
Trihydroxidoaluminium

Trade names:
AB H-Series Alumina Trihydrate
Actilox
ALH-……
ALOLT-……….
Alumina Hydrate
Alumina hydrate
Aluminium hydrate
Aluminium Hydroxide
Aluminium hydroxide
aluminium hydroxide
Aluminium trihydroxide
Aluminiumhydroxid
Aluminum hydroxide
Aluminum hydroxide highly dispersed precipitated
aluminum trihydrate
Apyral
BARIACE
BARIFINE
Bayerit
Geloxal
Hidróxido de aluminio
Hydrate
Hydrated alumina
hydroxid hlinitý
HYMOD® Surface-Treated Alumina Trihydrate
JR-800, MT-500SA etc.
KB-30, HS , HC, Hydrate, Aluminium hydroxide
MARTIFILL®
MARTIFIN®
MARTINAL®
MICRAL® Alumina Trihydrate
MOLDX® Optimized Alumina Trihydrate
ONYX ELITE® Alumina Trihydrate
R-11P
SB Alumina Trihydrate
Sigunit
SSP
STR
T-Lite
VOGA

Other names:
Aluminium oxide, hydrate
Aluminum hydroxide (Al(OH)3)
Aluminum oxide (Al2O3), hydrate
Aluminic acid
Aluminic hydroxide
Alumanetriol
Aluminium(III) hydroxide
Aluminium hydroxide
Aluminium trihydroxide
Hydrated alumina
Orthoaluminic acid

Other identifiers:
106152-09-4
1071843-34-9
12040-59-4
12252-70-9
128083-27-2
1302-29-0
1333-84-2
13783-16-9
151393-94-1
156259-59-5
159704-77-5
16657-47-9
1847408-13-2
21645-51-2
227961-51-5
51330-22-4
546141-62-2
546141-68-8
8012-63-3
8064-00-4
Gibberellic Acid
C11 oxoalcohol ethoxylate with 7 EO ; About 90 %; Liquid 52 – 55 (1); HLB: About 13
GLASS FLAKES

Glass flakes are thin, flat, platelet-shaped particles made of glass.
Glass flakes have a distinctive shimmering appearance due to their flat and reflective surfaces.
Glass flakes are lightweight and delicate, resembling tiny scales or flakes.



APPLICATIONS


Glass flakes are commonly used as additives in coatings to enhance corrosion resistance and mechanical strength.
Glass flakes find applications in automotive coatings to improve durability, scratch resistance, and provide an attractive finish.

Glass flakes are incorporated into plastics and composites to enhance their strength, dimensional stability, and impact resistance.
In the aerospace industry, glass flakes are used in the manufacturing of lightweight and high-strength composite materials.

Glass flakes are utilized in marine applications to enhance the durability and resistance to saltwater corrosion.
Glass flakes are added to adhesives and sealants to improve bonding strength, flexibility, and resistance to environmental factors.
Glass flakes are used in architectural coatings to provide weather resistance and decorative effects.
In the cosmetics industry, glass flakes are employed in nail polishes and cosmetic formulations to create a shimmering or glittering effect.

Glass flakes are utilized in decorative art and crafts projects to add visual interest and texture to artworks.
Glass flakes find applications in printing inks to create unique visual effects and enhance the appearance of printed materials.
Glass flakes are used in the formulation of specialty paints for applications such as metal finishes and industrial coatings.

Glass flakes can be incorporated into concrete and cementitious materials to enhance their strength and reduce cracking.
In the electronics industry, glass flakes are utilized in the manufacture of insulating materials and circuit boards.
Glass flakes find applications in the production of high-performance sports equipment such as tennis rackets and surfboards.

Glass flakes are used in the formulation of corrosion-resistant coatings for pipelines, storage tanks, and offshore structures.
Glass flakes are employed in the manufacturing of reflective road markings and traffic signs for improved visibility.
Glass flakes find applications in the formulation of protective coatings for bridges, infrastructure, and architectural structures.

Glass flakes can be added to ceramic glazes to create unique visual effects and improve the durability of the glaze.
Glass flakes are used in the formulation of anti-fouling coatings for boats and underwater structures to prevent marine growth.
Glass flakes are utilized in the production of high-end decorative glass products such as glass tiles and countertops.
Glass flakes find applications in the formulation of specialty inks for security printing and anti-counterfeiting measures.
Glass flakes can be incorporated into composite materials used in the construction of lightweight and high-strength panels.

Glass flakes are utilized in the formulation of heat-resistant coatings for applications in high-temperature environments.
Glass flakes find applications in the production of corrosion-resistant and decorative stainless steel finishes.
Glass flakes are used in the formulation of specialty paints for artistic and creative applications such as murals and sculptures.

Glass flakes are utilized in the production of reflective coatings for safety garments and high-visibility clothing.
Glass flakes find applications in the formulation of UV-resistant coatings for outdoor furniture and structures.
Glass flakes are incorporated into fiberglass reinforced plastics (FRP) to enhance their strength and impact resistance.
In the renewable energy sector, glass flakes are used in the manufacturing of wind turbine blades to improve their durability.
Glass flakes find applications in the formulation of heat-resistant paints for industrial furnaces, chimneys, and exhaust systems.

Glass flakes are utilized in the production of decorative glass beads and mosaic tiles for interior and exterior design.
Glass flakes are added to gel coats in the boat-building industry to improve the surface finish and resistance to water ingress.
Glass flakes find applications in the formulation of anti-corrosion coatings for steel structures and pipelines.
Glass flakes are used in the production of high-performance sports helmets to provide impact resistance and durability.
Glass flakes are employed in the formulation of protective coatings for electronics and electrical components.

Glass flakes find applications in the formulation of conductive inks for printed electronics and flexible circuitry.
Glass flakes can be incorporated into fiberglass insulation materials to improve their thermal resistance and strength.
Glass flakes are used in the formulation of fire-resistant coatings for building materials and fireproofing applications.
Glass flakes find applications in the formulation of thermal barrier coatings for gas turbines and engines.

Glass flakes are utilized in the production of decorative glassware, vases, and artistic glass sculptures.
Glass flakes find applications in the formulation of high-performance floor coatings for industrial and commercial spaces.
Glass flakes are added to paint formulations for road markings to enhance visibility and durability.
Glass flakes are employed in the formulation of high-gloss coatings for automotive and furniture finishes.
Glass flakes find applications in the production of specialty glass fibers used in optical communication and fiber optics.
Glass flakes are used in the formulation of conductive coatings for EMI shielding and static dissipation.

Glass flakes are utilized in the manufacturing of reflective films for traffic signs and safety markings.
Glass flakes find applications in the production of architectural glass panels with enhanced strength and impact resistance.
Glass flakes are added to polymer composites used in the aerospace industry to improve structural integrity and weight reduction.
Glass flakes are employed in the formulation of high-performance brake pads and friction materials for automotive applications.
Glass flakes find applications in the production of specialty papers and coatings with unique visual effects and textures.


Here are some common applications of glass flakes:

Coatings:
Glass flakes are widely used as additives in coatings to enhance their performance.
They improve corrosion resistance, barrier properties, and mechanical strength of coatings.
Glass flakes also provide aesthetic effects such as sparkle or metallic-like appearance.

Plastics and Composites:
Glass flakes are incorporated into plastics and composites to improve their mechanical properties.
They enhance strength, dimensional stability, impact resistance, and reduce warping or deformation.
Glass flakes are commonly used in automotive parts, sports equipment, and construction materials.

Adhesives and Sealants:
Glass flakes are utilized in the formulation of adhesives and sealants to enhance their strength, durability, and resistance to environmental factors.
Glass flakes improve bonding properties and prevent moisture penetration.

Automotive Industry:
Glass flakes are employed in automotive coatings to enhance durability, scratch resistance, and weatherability.
Glass flakes provide an attractive appearance and protect the surface from corrosion and UV radiation.

Cosmetics:
Glass flakes are used in nail polishes, lip glosses, and other cosmetic products to create a shimmering or glittering effect.
Glass flakes add sparkle and visual appeal to cosmetic formulations.

Decorative Art and Crafts:
Glass flakes find applications in decorative art and crafts projects to create visually striking effects.
Glass flakes are used in resin art, mixed media, and other creative applications to add sparkle, texture, and dimension to artworks.

Electrical Insulation:
Glass flakes with their non-conductive nature are employed in electrical insulation materials, such as insulating tapes and coatings.
Glass flakes help improve the electrical resistance and insulation properties of these materials.

Marine and Aerospace Industries:
Glass flakes are utilized in the manufacture of composite materials for marine and aerospace applications.
Glass flakes enhance the strength, stiffness, and impact resistance of composite structures, making them suitable for demanding environments.

Printing Inks:
Glass flakes are incorporated into specialty printing inks to create unique visual effects and add texture.
Glass flakes provide a metallic or shimmering appearance to printed materials.

Construction Materials:
Glass flakes are used in construction materials like paints, coatings, and sealants to improve their performance.
Glass flakes enhance durability, weather resistance, and provide a decorative finish.



DESCRIPTION


Glass flakes, also known as glass microflakes or glass flake pigments, are thin, flat, and platelet-shaped particles made of glass.
Glass flakes are typically composed of a combination of different types of glass, such as soda-lime or borosilicate glass.
The exact composition can vary depending on the specific application and manufacturer.

Glass flakes have unique properties that make them suitable for a wide range of industrial applications.
Glass flakes have a high aspect ratio, meaning their length and width dimensions are significantly larger than their thickness.
This characteristic gives glass flakes their distinctive platelet shape.

Glass flakes are chemically inert and resistant to chemicals, moisture, and UV radiation.
Glass flakes offer excellent thermal stability and mechanical strength.
These properties make them valuable additives in various industries, including coatings, plastics, composites, and adhesives.

In coatings, glass flakes are often used to enhance corrosion resistance, barrier properties, and mechanical strength.
Glass flakes can improve the durability, weatherability, and scratch resistance of the coating.
Glass flakes also contribute to the aesthetics of the coating, providing unique visual effects such as sparkle or metallic-like appearance.

In plastics and composites, glass flakes can be incorporated to improve strength, dimensional stability, and impact resistance.
Glass flakes can enhance the mechanical properties of the material, making it more robust and resistant to deformation.

Glass flakes are available in different sizes and thicknesses, allowing for customization based on the desired effect and application requirements.
Glass flakes can be transparent or colored, further expanding their range of applications.

Glass flakes are thin, flat, platelet-shaped particles made of glass.
Glass flakes have a distinctive shimmering appearance due to their flat and reflective surfaces.
Glass flakes are lightweight and delicate, resembling tiny scales or flakes.

Glass flakes come in various sizes, ranging from micrometers to millimeters in diameter.
Glass flakes exhibit a high aspect ratio, with their length and width significantly larger than their thickness.
These flakes can be transparent or colored, offering a wide range of visual effects.

Glass flakes are chemically inert, making them resistant to chemical reactions and degradation.
Glass flakes have excellent resistance to moisture, UV radiation, and weathering.
Glass flakes contribute to the mechanical strength and durability of composite materials.
Glass flakes can enhance the dimensional stability of plastics and composites, reducing warping or deformation.

Glass flakes can improve the barrier properties of coatings, providing corrosion resistance and moisture protection.
The use of glass flakes in coatings enhances scratch and abrasion resistance.
Glass flakes offer thermal stability, making them suitable for applications in high-temperature environments.
These flakes are lightweight additives that do not significantly increase the density of the material.

Glass flakes can be easily dispersed in various matrices, such as polymers, resins, and solvents.
Glass flakes provide a unique visual effect, adding sparkle, shimmer, or metallic-like appearance to coatings or plastics.
Glass flakes are widely used in automotive coatings to enhance the aesthetic appeal and durability of the finish.

In the cosmetics industry, glass flakes are utilized in nail polishes and decorative products for a glittering effect.
Glass flakes are employed in the formulation of specialty paints and coatings for architectural and industrial applications.
Glass flakes can be incorporated into adhesives and sealants to improve their strength and resistance to environmental factors.
These flakes have a smooth surface, minimizing the risk of abrasion or damage to other materials in contact.
Glass flakes are commonly used in the manufacture of composite materials for aerospace and marine applications.

Glass flakes contribute to the electrical insulation properties of certain materials due to their non-conductive nature.
Glass flakes provide a visually striking effect in decorative art and crafts projects.
The use of glass flakes in various industries adds a touch of elegance and sophistication to the final product.



PROPERTIES


Shape: Glass flakes are thin, flat, and platelet-shaped particles.
Aspect Ratio: They have a high aspect ratio, with their length and width significantly larger than their thickness.
Appearance: Glass flakes have a reflective and shimmering appearance.
Composition: They are primarily composed of glass, which can vary in type (such as soda-lime or borosilicate glass) depending on the manufacturer and application.
Size Range: Glass flakes are available in various sizes, ranging from micrometers to millimeters in diameter.
Transparency: Glass flakes can be transparent or colored, providing a wide range of visual effects.
Chemical Inertness: Glass flakes are chemically inert and resistant to chemical reactions and degradation.
Moisture Resistance: They exhibit excellent resistance to moisture and do not easily absorb water.
UV Resistance: Glass flakes are resistant to UV radiation and do not degrade under prolonged exposure to sunlight.
Weatherability: They offer good weather resistance, maintaining their properties and appearance over extended periods in outdoor environments.
Thermal Stability: Glass flakes exhibit excellent thermal stability and can withstand high-temperature environments without deformation or degradation.
Mechanical Strength: They contribute to the mechanical strength of materials when incorporated as additives, enhancing resistance to deformation and impact.
Lightweight: Glass flakes are lightweight additives that do not significantly increase the density of the material.
Chemical Resistance: They are resistant to many chemicals and provide a protective barrier against corrosion and chemical attack.
Electrical Insulation: Glass flakes are non-conductive and can provide electrical insulation properties when incorporated into suitable materials.



FIRST AID


Inhalation:

If glass flakes are inhaled, remove the affected person to an area with fresh air.
If respiratory symptoms occur or breathing is difficult, seek immediate medical attention.
Provide oxygen or artificial respiration if necessary.
Keep the person calm and reassured while medical assistance is sought.


Skin Contact:

Remove any contaminated clothing or accessories.
Gently brush off or rinse away glass flakes from the skin using plenty of water.
If skin irritation or redness develops, wash the affected area with mild soap and water.
Seek medical attention if skin irritation persists or if large areas of the skin are affected.


Eye Contact:

Immediately flush the eyes with gentle, lukewarm water for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.
Remove contact lenses, if applicable, after rinsing for a few minutes.
Seek immediate medical attention even if there are no initial symptoms of irritation or injury.


Ingestion:

In case of accidental ingestion of glass flakes, do not induce vomiting.
Rinse the mouth with water if flakes are present, but do not swallow the water.
Seek immediate medical attention or contact a poison control center for guidance.



HANDLING AND STORAGE


Handling Conditions:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including safety goggles or glasses, gloves, and a dust mask or respiratory protection, to minimize the risk of exposure to glass flakes.

Ventilation:
Work in a well-ventilated area or use local exhaust ventilation to control and remove any dust or airborne particles generated during handling.

Avoiding Skin Contact:
Minimize direct skin contact with glass flakes by wearing long-sleeved clothing and pants.
Avoid rubbing or touching your face or eyes while handling the material.

Preventing Inhalation:
Avoid breathing in dust or aerosols generated by glass flakes.
Use appropriate respiratory protection, such as a dust mask or respirator, when handling in dusty environments.

Handling Tools:
Use appropriate tools or equipment to handle glass flakes, such as scoops, tongs, or dedicated containers, to minimize the risk of spills or accidents.

Spill Management:
In case of spills, carefully collect glass flakes using non-sparking tools and place them in a suitable container for proper disposal.
Avoid creating dust or dispersing the flakes into the air.

Hygiene Practices:
Practice good personal hygiene, including washing hands thoroughly with soap and water after handling glass flakes, and before eating, drinking, or smoking.


Storage Conditions:

Suitable Containers:
Store glass flakes in tightly sealed, labeled containers made of suitable materials such as plastic or glass.
Ensure the containers are compatible with the material and prevent leakage or breakage.

Temperature and Humidity:
Store glass flakes in a cool, dry area away from direct sunlight and extreme temperatures to maintain their quality and prevent degradation.

Separate from Incompatible Substances:
Store glass flakes away from strong oxidizing agents, acids, and other incompatible substances to avoid potential reactions or contamination.

Avoiding Mechanical Damage:
Handle and store containers with care to prevent damage or breakage, which could release glass flakes into the surrounding environment.

Fire Safety:
Glass flakes are not combustible, but as a general precaution, store them away from potential ignition sources and follow established fire safety regulations.

Accessibility:
Store glass flakes in a designated area with clear labeling to ensure easy identification and access, and to prevent accidental contact or misuse.

Security:
If necessary, store glass flakes in a secure area or locked storage cabinet to prevent unauthorized access or tampering.

Inventory Management:
Keep track of inventory and practice a first-in, first-out (FIFO) approach to ensure the use of older stock before newer batches.



SYNONYMS


Glass platelets
Glass powders
Glass microflakes
Glass granules
Glass particles
Glass shards
Glass fragments
Glass chips
Glass splinters
Glass shreds
Glass scales
Glass slivers
Glass dust
Glass grains
Glass fragments
Glass fibers
Glass crystals
Glass shards
Glass specks
Glass slabs
Glass shards
Glass shards
Glass grains
Glass crumbs
Glass crumbs
Glass slivers
Glass splinters
Glass shards
Glass fragments
Glass chips
Glass bits
Glass particles
Glass dust
Glass grit
Glass powder
Glass specks
Glass speckles
Glass crystals
Glass shards
Glass granules
Glass shards
Glass fragments
Glass fibers
Glass slabs
Glass scales
Glass shards
Glass crumbs
Glass grains
Glass shavings
Glass grits
GLİKOLİK ASİT %70
Glikolik asit %70, glikolik asit konsantrasyonunun %70 olduğu sudaki bir glikolik asit çözeltisidir.
Glikolik asit %70 şeker kamışı gibi doğal kaynaklardan elde edilir ve peeling özellikleriyle bilinir.

CAS Numarası: 79-14-1
EC Numarası: 201-180-5

Glikolik asit, hidroksiasetik asit, hidroksietanoik asit, alfa-hidroksiasetik asit, 2-hidroksietanoik asit, glikolik asit, hidroasetik asit, alfa-hidroksietanoik asit, 2-hidroksiasetik asit, asit hidroksiasetik, asit hidroksiasetikum, asit glikolik, asit glikolikum, AHA, EGHPA , alfa-hidroksi-asetik asit, hidroksi-asetik asit, hidroksietanoik asit, hidroksietanoat, glikolik asit çözeltisi, glikolik asit USP, glikolik asit FCC, glikolik asit kozmetik sınıfı, glikolik asit farmasötik sınıfı, glikolik asit teknik sınıfı, glikolik asit yüksek saflıkta, glikolik asit %70, glikolik asit %99, glikolik asit %90, glikolik asit %80, glikolik asit %30, glikolik asit %10, glikolik asit %50, glikolik asit %60, glikolik asit losyonu, glikolik asit krem, glikolik asit jel, glikolik asit peelingi, glikolik asit toneri, glikolik asit temizleyici, glikolik asit serumu, glikolik asit nemlendirici, glikolik asit eksfoliyantı, glikolik asit kimyasal peeling, glikolik asit cilt bakımı, glikolik asit yaşlanma karşıtı, glikolik asit parlatıcı, glikolik asit gençleştirici, glikolik asit yüzey yenileme, glikolik asit akne tedavisi, glikolik asit kırışıklık azaltma, glikolik asit gözenek inceltme, glikolik asit kimyasal eksfoliasyon, glikolik asit alfa hidroksi asit, glikolik asit doğal kaynağı, glikolik asit şeker kamışından türetilmiş, glikolik asit bitkiden türetilmiş, glikolik asit meyve asidi .



UYGULAMALAR


Glikolik asit %70, kimyasal peelinglerde geniş uygulama alanı bulur ve cilt gençleştirme için kontrollü eksfoliasyon sunar.
Glikolik asit %70, peeling temizleyicilerin önemli bir bileşenidir ve daha parlak bir cilt için ölü cilt hücrelerinin temizlenmesine yardımcı olur.
Tonerlerde yaygın olarak %70 oranında glikolik asit bulunur ve cilt pH seviyelerinin dengelenmesine ve dokuların iyileştirilmesine yardımcı olur.

Yaşlanma karşıtı serumlarda glikolik asit, daha genç bir görünüm için ince çizgilerin ve kırışıklıkların azaltılmasına katkıda bulunur.
Hiperpigmentasyonu gidermede etkili olan bu madde, cilt aydınlatma ürünlerinde değerli bir bileşendir.

Sivilceyle mücadele eden formülasyonlar genellikle gözenekleri açmak ve sivilceleri önlemek için glikolik asit içerir.
Nemlendiricilerde %70 oranında glikolik asit bulunur ve cildin nemlendirilmesi için nemlendirici özelliklerinden yararlanılır.
Glikolik asit içeren gece maskeleri, cildin onarıcı döneminde sürekli eksfoliasyon ve nemlendirme sağlar.
Koyu nokta düzelticiler genellikle hiperpigmentasyonu hedeflemek ve azaltmak için glikolik asit içerir.

Dudak balsamları ve tedavileri, yumuşak ve pürüzsüz dudakları korumak amacıyla hafif pul pul dökülme için glikolik asit kullanır.
Glikolik asit %70, şampuanların arındırılmasına katkıda bulunarak saç ve saç derisindeki ürün birikiminin giderilmesine yardımcı olur.
Saç derisine olan potansiyel faydaları nedeniyle kepek önleyici şampuanlarda %70 oranında glikolik asit kullanılır.
Glikolik asit %70, göz kremlerinde yaygın olarak kullanılan bir içeriktir ve hassas göz bölgesindeki yaşlanma belirtilerini giderir.

Vücut losyonlarında bulunan %70 Glikolik asit, vücudun çeşitli bölgelerinde daha pürüzsüz ve yumuşak bir cilde katkıda bulunur.
Vücut peelinglerinde %70 Glikolik asit, cildin yenilenmesi için genel bir peeling tedavisi sağlar.
Glikolik asit %70, yüz maskelerinde ek bir eksfoliasyon desteği sağlamak ve cildin canlanmasını desteklemek için kullanılır.
Cilt arındırıcı maskeler genellikle cildi detoksifiye etmek ve canlandırmak için glikolik asit içerir.

Glikolik asit %70, yüz astarlarında bulunan bir bileşendir ve makyaj uygulaması için daha pürüzsüz bir tuval oluşturur.
Kişisel bakım ürünleri, hassas bölgelerde nazik eksfoliasyon için glikolik asit içerebilir.
Saç bakım ürünleri, saç derisi sağlığı için glikolik asit içerir ve temiz ve dengeli bir ortam sağlar.
Güneş kremlerinde %70 oranında glikolik asit bulunur ve bu da genel güneş koruma etkinliğini artırır.
Cilt bakım mendillerinde kullanılır, kullanışlı ve hızlı bir eksfoliasyon çözümü sağlar.

Saç derisi serumlarına %70 oranında glikolik asit dahil edilerek sağlıklı bir saç derisi ortamı ve saç büyümesini destekler.
Saç derisi peeling tedavilerinde kepeği gidermek ve sağlıklı bir saç derisini desteklemek için glikolik asit kullanılır.
Serinletici yüz sisleri genellikle glikolik asit içerir ve hareket halindeyken nemlendirme ile cilt için ilave faydalar sunar.

Glikolik asit %70, peeling serumlarının önemli bir bileşenidir ve daha pürüzsüz ve daha parlak bir cilt için günlük bir bakım sağlar.
Glikolik asit %70, ayaklardaki pürüzlü cilt dokusunu gidermek için ayak kremlerinde ve peeling peelinglerinde yaygın olarak kullanılır.
El kremlerinde %70 oranında glikolik asit bulunur ve ellerdeki cildin gençleşmesine katkıda bulunur.

Dudak peelinglerinde %70 Glikolik asit, daha yumuşak ve pürüzsüz dudaklar için yumuşak bir eksfoliasyon sunar.
Glikolik asit %70, yüz spreylerinde kullanılır, tazeleyici ve nemlendirici bir sprey sağlar ve cilde ilave faydalar sağlar.
Glikolik asit %70, koyu lekeler veya eşit olmayan cilt tonu gibi belirli cilt bakımı sorunlarını hedeflemek için tasarlanmış serumlarda bulunan değerli bir bileşendir.
Uygun ve kontrollü eksfoliasyon için önceden ıslatılmış pedlere %70 oranında glikolik asit dahildir.

Glikolik asit %70 genellikle ağda sonrası losyonlarda bulunur ve cildi rahatlatmaya ve kıl dönmesini önlemeye yardımcı olur.
Glikolik asit %70, özel yıkamalarda ve temizleyicilerde kullanılır ve hassas bölgeler için yumuşak bir eksfoliasyon sağlar.
Yüz pudralarında %70 oranında glikolik asit bulunur ve yağ emici ve cilt yumuşatıcı özelliklere katkıda bulunur.

Yüz peelinglerinde bulunan glikolik asit, yoğun cilt yenileme tedavileri sunar.
Glikolik asit %70, kütikül yağlarında bulunan bir bileşendir ve sağlıklı tırnaklar için hedefe yönelik bakım ve beslenmeye katkıda bulunur.
Dövme sonrası bakım ürünlerinde %70 glikolik asit kullanılır, cildin iyileşmesine yardımcı olur ve tahrişi azaltır.

Selülit önleyici kremlerde cildin sıkılığına ve tonusuna katkıda bulunarak daha pürüzsüz bir görünüm elde edilmesini sağlar.
Glikolik asit çatlak kremlerinde bulunur ve cildin elastikiyetini artırır.

Göz maskelerinde %70 glikolik asit kullanılarak yorgunluk belirtilerine ve göz çevresindeki ince çizgilere çözüm bulunur.
Glikolik asit %70 yaygın olarak vücut yıkama ürünlerinde bulunur ve yenilenmiş cilt için tüm vücutta eksfoliasyon sağlar.
Glikolik asit %70, cilt bakımı endişesi olan belirli bölgelere hedeflenen uygulama için leke tedavilerine dahildir.

Glikolik asit %70, peeling saç derisi fırçalarında bulunan ve fiziksel ve kimyasal peelingin bir kombinasyonunu sağlayan bir bileşendir.
Vücut serumlarında bulunan bu madde, genel cilt yenileme ve parlatma etkisine katkıda bulunur.

Yüz temizleyicilerinde %70 oranında glikolik asit kullanılır ve temiz ve tazelenmiş bir cilt için günlük peeling sunar.
Koltuk altı aydınlatıcı kremlerde %70 oranında glikolik asit bulunur ve daha eşit bir cilt tonuna katkıda bulunur.

Glikolik asit %70, ferahlatıcı ve tüy giderici bir etki için soğutma göz jellerinde yaygın olarak kullanılır.
Kütikül yumuşatıcılara %70 oranında glikolik asit dahil edilerek kütikül oluşumunun nazikçe giderilmesine yardımcı olur.

Yüz bantlarında %70 oranında glikolik asit bulunur ve belirli cilt bakımı sorunları için hedefe yönelik tedavi sağlar.

Glikolik asit %70, bireysel sivilce lekelerinin hedefe yönelik bakımı için leke tedavi bantlarında bulunur.
Glikolik asit %70, misel su formülasyonlarında yaygın olarak kullanılır ve yumuşak ve etkili bir makyaj temizleme çözümü sağlar.

Saç derisi peeling tedavilerinde %70 oranında glikolik asit bulunur, pullanmayı giderir ve sağlıklı bir saç derisini destekler.
Yüz astarlarında %70 Glikolik asit, daha iyi makyaj uygulaması için daha pürüzsüz bir cilt yüzeyine katkıda bulunur.

Sağlıklı bir saç derisinin derinlemesine eksfoliasyonu ve bakımı için saç derisi peelinglerinde %70 glikolik asit kullanılır.
Uzun süreli cilt yenilenmesi için serum ve kremler gibi durulanmayan peeling tedavilerinde %70 oranında glikolik asit bulunur.
Glikolik asit %70, ayak peelinglerinde ve maskelerinde yaygın olarak kullanılır ve daha pürüzsüz ayaklar için nasırlı bölgeleri hedef alır.
Tırnak eti kremlerine %70 oranında glikolik asit eklenerek sağlıklı tırnakların ve çevresindeki cildin korunmasına yardımcı olur.

Gece maskelerinde %70 Glikolik asit, cilt dinlenirken sürekli eksfoliasyon ve nemlendirme sağlar.
El dezenfektanlarında %70 oranında glikolik asit bulunur ve hem sanitizasyona hem de cilt bakımına katkıda bulunur.
Glikolik asit %70, özel yıkamalarda ve temizleyicilerde kullanılarak hassas bölgelerde nazik eksfoliasyon sağlar.

Dövme sonrası bakım ürünlerinde %70 oranında glikolik asit bulunur, cilt iyileşmesini destekler ve tahrişi azaltır.
Glikolik asit %70, gelişmiş peeling etkileri için diğer alfa hidroksi asitlerle kombinasyon halinde kullanılır.

Glikolik asit %70, yüz peelinglerinde daha yoğun cilt sorunlarına yönelik önemli bir bileşendir.
Sivilce lekesi jellerinde %70 oranında glikolik asit bulunur ve lekeler ve sivilceler için hedefe yönelik tedavi sağlar.

Saç derisine olan potansiyel faydaları nedeniyle kepek önleyici şampuanlarda %70 glikolik asit kullanılır.
Makyajı çözme ve cildi yenileme özelliği nedeniyle makyaj temizleyicilere %70 oranında glikolik asit eklenir.
Yaşlanma karşıtı formülasyonlarda sinerjistik bir etki için retinoidlerle kombinasyon halinde %70 glikolik asit kullanılır.

Dudak peelinglerinde %70 oranında glikolik asit bulunur ve daha pürüzsüz dudaklar için yumuşak bir eksfoliasyon sağlar.
Güneşten koruyucu formülasyonlarda %70 oranında glikolik asit bulunur ve güneş kaynaklı hasarın önlenmesine yardımcı olur.
Hedeflenen bakım ve beslenme için kütikül yağlarında %70 glikolik asit kullanılır.

Çatlak kremlerinde %70 oranında glikolik asit kullanılır ve cildin elastikiyetinin artmasına katkıda bulunur.
Daha yoğun bir el gençleştirme tedavisi için el peelinglerinde %70 oranında glikolik asit bulunur.

Etkili ancak nazik günlük eksfoliasyon için temizleyicilerde %70 glikolik asit kullanılır.
Saç derisi peeling tedavilerinde kepeği giderir ve sağlıklı bir saç derisi ortamını destekler.



TANIM


Glikolik asit %70, glikolik asit konsantrasyonunun %70 olduğu sudaki bir glikolik asit çözeltisidir.
Glikolik asit %70 şeker kamışı gibi doğal kaynaklardan elde edilir ve peeling özellikleriyle bilinir.

Cilt bakımında glikolik asit, cildin yenilenmesini destekleme, dokuyu iyileştirme ve çeşitli cilt sorunlarına çözüm bulma yeteneği nedeniyle yaygın olarak kullanılır.
%70'lik konsantrasyon nispeten yüksek bir mukavemete işaret eder ve bu konsantrasyona sahip solüsyonlar genellikle dermatolog muayenehaneleri veya cilt bakım klinikleri gibi profesyonel ortamlarda kimyasal peeling ve daha yoğun cilt tedavileri için kullanılır.

Glikolik asit %70, dikkate değer kimyasal özelliklere sahip, renksiz ve kokusuz bir sıvıdır.
Glikolik asit %70 alfa-hidroksi asit ailesine aittir ve şeker kamışı gibi doğal kaynaklardan elde edilir.
Suda çözünürlüğü ile bilinen glikolik asit, cilt bakımı formülasyonlarında sıklıkla kullanılır.
Glikolik asit %70, cilt üzerindeki güçlü peeling etkisi ile tanınır.

Küçük moleküler boyutuyla glikolik asit cilde etkili bir şekilde nüfuz ederek cildin yenilenmesine yardımcı olur.
Çoğunlukla kimyasal peelinglerde kullanılan bu ürün, çeşitli cilt sorunları için kontrollü eksfoliasyon sunar.
Glikolik asit %70 kollajen üretimini uyararak cilt elastikiyetinin artmasına katkıda bulunur.
Hiperpigmentasyona karşı etkili olup koyu lekelerin görünümünü azaltır.

Glikolik asit %70 gözeneklerin açılmasında değerlidir, bu da onu sivilceye yatkın ciltler için faydalı kılar.
Çeşitli cilt bakım ürünlerinde bulunan glikolik asit, diğer bileşenlerin emilimini artırır.
Glikolik asit %70 farklı cilt tipleri için uygundur, ancak hassasiyet için yama testi önerilir.

Yaşlanma karşıtı formülasyonların önemli bir bileşeni olan glikolik asit, ince çizgileri ve kırışıklıkları en aza indirir.
Cildin yenilenmesini teşvik ederken, güneş ışığına karşı hassasiyeti geçici olarak artırabilir.
Düzenli kullanım, daha eşit bir cilt tonuna ve gözenek boyutunun azalmasına katkıda bulunur.
%70 glikolik asit, özellikle hassas ciltler için fiziksel peelinglere alternatif olarak hizmet eder.

Kimyasal eksfolyantlarda yaygın olarak kullanılan Glikolik asit %70, zamanla daha pürüzsüz bir cilt dokusu sağlar.
Cildin yüzeyini dönüştürme yeteneğiyle tanınan bu ürün, cilt bakımı rutinlerinin temelini oluşturur.
Nemlendirici özellikleri, glikolik asidin nemi çekmesi ve tutması için etkili olmasını sağlar.

Kullanıcılar, uygulama sonrasında zamanla normalleşen bir karıncalanma hissi yaşayabilirler.
Çeşitli konsantrasyonlara uygun olup hem günlük rutinlerde hem de profesyonel tedavilerde kullanılır.
Glikolik asit %70 kimyasal eksfoliasyon sunarak genç ve canlanmış bir görünüme katkıda bulunur.
Aydınlatıcı ürünlerde yaygın bir seçim olan bu ürün, cildi gençleştirerek ışıltılı bir parlaklık sağlar.

Çok yönlülüğü, yaşlanmanın yaygın belirtilerini ve çeşitli cilt sorunlarını gidermeye kadar uzanır.
Düzenli kullanım, artan hücre yenilenmesinin bir sonucu olarak daha rafine ve pürüzsüz bir cilt dokusuna yol açar.
Cilt bakımı endüstrisinde geniş çapta kutlanan glikolik asit, etkili kimyasal eksfoliasyon için bir başvuru kaynağı olmaya devam ediyor.



ÖZELLİKLERİ


Kimyasal Adı: Glikolik asit
Kimyasal Formül: C ₂ H ₄ O ₃
Molekül Ağırlığı: Yaklaşık 76,05 g/mol
Fiziksel Form: Berrak, renksiz sıvı veya beyaz kristal katı (konsantrasyona bağlı olarak)
Koku: Kokusuz veya hafif karakteristik bir koku
Çözünürlük: Suda yüksek oranda çözünür ve yaygın organik çözücülerle karışabilir
pH: Asidik; genellikle çözeltide 3,5 civarında
Higroskopisite: Havadaki nemi emebilir
Erime Noktası: Erimeden ayrışır; genellikle uygulanamaz
Kaynama Noktası: Standart atmosferik basınç altında kaynamadan önce ayrışır
Yoğunluk: Konsantrasyona ve forma bağlıdır; saf sıvı için tipik olarak yaklaşık 1,27 g/cm³
Viskozite: Sıvı formda düşük viskozite
Kırılma İndeksi: Konsantrasyona bağlıdır; tipik olarak 1,42 ile 1,45 arasında değişir
Kararlılık: Normal saklama koşulları altında kararlıdır; aşırı ısı veya ışığa maruz kalma durumunda bozulabilir
Uyumluluk: Suyla ve çeşitli kozmetik ve farmasötik bileşenlerle uyumludur
Güvenlik: Belirtilen konsantrasyonlarda cilt bakımında kullanım için genel olarak güvenli olduğu kabul edilir.
Biyobozunurluk: Biyolojik olarak parçalanabilir kabul edilir
Depolama Stabilite: Serin ve kuru bir yerde saklayın; doğrudan güneş ışığından koruyun
Özgül Ağırlık: Konsantrasyona ve forma bağlıdır; sıvı için tipik olarak 1,26 ile 1,29 arasında değişir
Parlama Noktası: Uygulanamaz; önemli derecede yanıcılık göstermez
Tehlikeli Ayrışma Ürünleri: Ayrışma sonucu karbon monoksit ve karbon dioksit üretebilir
Karışabilirlik: Su ve çeşitli organik solventlerle karışabilir
Yüzey Gerilimi: Konsantrasyona ve forma bağlı olarak; genellikle sudan daha düşük



İLK YARDIM


Solunum:

Glikolik asit dumanları solunursa ve solunum yolu tahrişi meydana gelirse, etkilenen kişiyi temiz hava alan bir alana taşıyın.
Solunum güçlüğü devam ederse derhal tıbbi yardım alın.
Kişi nefes almıyorsa suni teneffüs yapın.
Eğitimli personel varsa oksijen sağlayın.


Ten teması:

Konsantre glikolik asitin ciltle teması halinde, kirlenmiş giysileri derhal çıkarın.
Etkilenen cildi en az 15 dakika boyunca bol suyla iyice yıkayarak durulayın.
Tahriş veya kızarıklık oluşur ve devam ederse tıbbi yardım isteyin.
Kirlenmiş giysileri yeniden kullanmadan önce yıkayın.
Varsa ve glikolik asitle kullanımı onaylanmışsa nötrleştirici bir madde uygulayın.


Göz teması:

Gözle teması halinde, göz kapaklarını açık tutarak gözleri en az 15 dakika boyunca hafifçe akan ılık suyla yıkayın.
Tahriş veya kızarıklık devam ederse derhal tıbbi yardım alın.
İlk yıkamadan sonra, varsa ve yapılması kolaysa kontakt lensleri çıkarın ve durulamaya devam edin.
Varsa bir göz yıkama istasyonu kullanın.


Yutma:

Glikolik asit yutulursa ve kişinin bilinci yerindeyse ağzını suyla iyice çalkalayın.
Tıbbi personel tarafından yönlendirilmedikçe kusturmayın.
Derhal tıbbi yardım alın veya bir zehir kontrol merkeziyle iletişime geçin.
Konsantrasyon da dahil olmak üzere, yutulan spesifik glikolik asit ürünü hakkında bilgi sağlayın.


Genel tavsiye:

Tıbbi personele, ilgili spesifik glikolik asit ürünü hakkında, konsantrasyonu da dahil olmak üzere bilgi sağlayın.
Semptomlar devam ederse veya kişinin sağlığıyla ilgili endişeler varsa derhal tıbbi yardım isteyin.
Üretici tarafından sağlanan güvenlik veri sayfasında (SDS) belirtilen tüm tavsiyelere ve önlemlere uyun.
Tıbbi personele gerekli bilgileri sağlamak için ürün kabını veya etiketini erişilebilir tutun.



TAŞIMA VE DEPOLAMA


İşleme:

Kişisel Koruyucu Donanım (PPE):
Kimyasallara dayanıklı eldivenler, koruyucu gözlükler veya yüz siperliği ve laboratuvar önlüğü veya koruyucu giysiler de dahil olmak üzere uygun KKD kullanın.
Buharlara veya aerosollere soluma yoluyla maruz kalma riski varsa, NIOSH onaylı bir solunum cihazı kullanın.

Havalandırma:
İyi havalandırılmış bir alanda, tercihen çeker ocak altında veya yerel egzoz havalandırması ile çalışın.
Buharları veya buğuyu solumaktan kaçının.

Temastan kaçının:
Uygun eldivenler giyerek cilt temasını en aza indirin.
Göz temasından kaçının; İşlem sırasında koruyucu gözlük veya yüz siperi kullanın.

Kullanım Önlemleri:
Dökülmeleri en aza indirmek için pipetler veya dağıtım sistemleri gibi araçları kullanın.
Sıçramayı veya aerosol oluşumunu önlemek için dikkatli kullanın.

Hijyen Uygulamaları:
Glikolik asitle temas ettikten sonra ellerinizi iyice yıkayın.
Kirlenmiş giysilerinizi derhal değiştirin.

Önleyici tedbirler:
Taşıma sırasında aerosol veya toz oluşumunu önlemek için önlemler uygulayın.
Mümkün olduğunda kapalı sistemler veya konteynerler kullanın.

İlk yardım:
Yakınlarda acil durum göz yıkama istasyonlarının ve güvenlik duşlarının mevcut olduğundan emin olun.


Depolama:

Depolama alanı:
Glikolik asidi serin, kuru ve iyi havalandırılan bir alanda saklayın.
Uyumsuz malzemelerden ve ısı kaynaklarından uzak tutun.

Sıcaklık kontrolü:
Üretici tarafından sağlanan önerilen saklama sıcaklığına uyun.
Aşırı sıcaklıklara maruz kalmaktan kaçının.

Konteyner Uyumluluğu:
Cam veya yüksek yoğunluklu polietilen (HDPE) gibi glikolik asitle uyumlu malzemelerden yapılmış kaplar kullanın.
Konteynerin bütünlüğünü düzenli olarak kontrol edin.

Etiketleme:
Kapları ürün adı, konsantrasyon, kullanım talimatları ve güvenlik bilgileri ile açıkça etiketleyin.
Kapları uygun tehlike sembolleriyle işaretleyin.

Ayrışma:
Glikolik asidi, güçlü bazlar ve oksitleyici maddeler de dahil olmak üzere uyumsuz maddelerden ayırın.
Yiyecek ve içeceklerden uzakta saklayın.

Ulaşılabilirlik:
Depolama alanının yetkili personel ve acil müdahale ekipleri tarafından kolayca erişilebilir olduğundan emin olun.
Acil durum çıkışlarını ve tahliye yollarını açıkça işaretleyin.

İzleme:
Önerilen yönergelere uygunluğu sağlamak için saklama koşullarını düzenli olarak inceleyin.
Kaplarda sızıntı veya hasar olup olmadığını kontrol edin.

Acil Durum ekipmanı:
Dökülme müdahale kitleri ve yangın söndürücüler gibi acil durum ekipmanlarının mevcut olduğundan emin olun.
Acil durum ekipmanının doğru kullanımı konusunda personeli eğitin.

Dökülmeye Müdahale:
Emici malzemeler ve nötrleştirici maddeler de dahil olmak üzere dökülmeye karşı müdahale malzemelerini hazır bulundurun.
Yerleşik dökülme müdahale prosedürlerini takip edin.

Belgeler:
Teslim alma ve kullanım tarihleri de dahil olmak üzere glikolik asit envanterinin doğru kayıtlarını tutun.


Gliserin
GLUCAMINE, N° CAS : 488-43-7 Nom INCI : GLUCAMINE N° EINECS/ELINCS : 207-677-3 Ses fonctions (INCI) Conditionneur capillaire : Laisse les cheveux faciles à coiffer, souples, doux et brillants et / ou confèrent volume, légèreté et brillance Humectant : Maintient la teneur en eau d'un cosmétique dans son emballage et sur la peau
GLUCAM E 10
DESCRIPTION:
GLUCAM E 10 humectant is a naturally-derived, mild ingredient that delivers moisture to the skin while reducing the tacky feel normally associated with the ingredients typically used in moisturizing skin creams.
GLUCAM E 10 is an ethoxylated methyl glucose ether and is 100% active.
Its low irritation potential makes GLUCAM E 10 ideal for use in both rinse off and leave on skin care systems such as lotions, creams, and body cleansing formulations.

CAS Number: 68239-42-9
INCI Name: Methyl Gluceth
Composition: Methyl Gluceth-10
Synonym: Methyl Gluceth-10


CHEMICAL AND PHYSICAL PROPERTIES OF GLUCAM E 10:
XlogP3-AA: -3.20 (est)
Molecular Weight: 370.39610000
Formula: C15 H30 O10
Boiling point °F: 601.F
Boiling point °C: 316.C
INCI Name: Methyl Gluceth
Composition: Methyl Gluceth-10
Specific gravity 1.20
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 562.00 to 563.00 °C. @ 760.00 mm Hg (est)
Flash Point: 561.00 °F. TCC ( 294.00 °C. ) (est)
logP (o/w): -4.430 (est)
Soluble in:
water, 1e+006 mg/L @ 25 °C (est)
Odor Strength:none
Odor Description:at 100.00 %. bland

FEATURES/BENEFITS OF GLUCAM E 10:
GLUCAM E 10 Does not interfere with foam properties
GLUCAM E 10 is Effective moisturizer
GLUCAM E 10 is Film plasticizer

GLUCAM E 10 is Glossing aid
GLUCAM E 10 is Naturally derived
GLUCAM E 10 Reduces tacky feel of formulations containing high levels of glycerine

GLUCAM E 10 is Smooth, silky feel
GLUCAM E 10 is Very effective freezing point depressant.

GLUCAM E 10 humectant is a mild humectant, film plasticizer and moisturizer.
GLUCAM E 10 is naturally derived and delivers moisture to the skin while reducing the tacky feel.
GLUCAM E 10 is an ethoxylated methyl glucose ether.

GLUCAM E 10 offers low irritation, gloss and smooth silky feel.
GLUCAM E 10 is a very effective freezing point depressant and does not interfere with foam properties.
GLUCAM E 10 is ideal for use in both rinse off and leave on skin care systems.

GLUCAM E 10 humectant is used in body lotions/creams/gels, body cleansing formulations, color cosmetics, hair removal, hand sanitizer and intimate & mild cleansers.
Also, GLUCAM E 10 is used in hand soaps, wipes, shaving & styling products, eye-, facial-, hand/foot-, lip- and sun care products.

GLUCAM E 10 promotes the retention of moisture on the skin.
Increased moisture can increase an active ingredient’s solubility, which can then in turn increase the skin penetration.
These ingredients deliver light, satiny after-feel to skin formulations and are effective at reducing the tack of glycerin.

There are several creams on the market containing these IID-listed humectants and formulated with a variety of APIs.
Typical usage level of 1-5%.









APPLICATIONS OF GLUCAM E 10:

GLUCAM E 10 is used as Color Cosmetics
GLUCAM E 10 is used as Eye Area Skin Care Products
GLUCAM E 10 is used as Facial Care Products
GLUCAM E 10 is used as Hair Removal

GLUCAM E 10 is used in Hand Sanitizer
GLUCAM E 10 is used in Hand/Foot Care
GLUCAM E 10 is used in Intimate Cleansers

GLUCAM E 10 is used in Lip Care
GLUCAM E 10 is used in Mild Cleansers
GLUCAM E 10 is used in Shaving Products

GLUCAM E 10 is used in Sun Care
GLUCAM E 10 is used in Wipes



SAFETY INFORMATION ABOUT GLUCAM E 10:

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

SYNONYMS OF GLUCAM E 10:
Methyl Gluceth-10;
Unicam E10;
Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with methyl D-glucopyranoside (4:1);
Ethoxylated methyl D-glucoside





GLUCAM E-10
DESCRIPTION:

Glucam E-10 humectant is a naturally-derived, mild ingredient that delivers moisture to the skin while reducing the tacky feel normally associated with the ingredients typically used in moisturizing skin creams.
Glucam E-10 is an ethoxylated methyl glucose ether and is 100% active.
Its low irritation potential makes it ideal for use in both rinse off and leave on skin care systems such as lotions, creams, and body cleansing formulations.

INCI Name: Methyl Gluceth-10



Glucam E-10 is a substance that promotes the retention of moisture on the skin.
This increased moisture can increase an active ingredient’s solubility, which can then in turn increase the skin penetration.

These ingredients deliver light, satiny after-feel to skin formulations and are effective at reducing the tack of glycerin.
There are several creams on the market containing these IID-listed humectants and formulated with a variety of APIs.
Typical usage level of Glucam E-10 is 1-5%.




FEATURES/BENEFITS OF GLUCAM E-10:
Glucam E-10 Does not interfere with foam properties
Glucam E-10 is Effective moisturizer
Glucam E-10 is Film plasticizer

Glucam E-10 is Glossing aid
Glucam E-10 is Naturally derived
Glucam E-10 Reduces tacky feel of formulations containing high levels of glycerine

Glucam E-10 has Smooth, silky feel
Glucam E-10 is Very effective freezing point depressant



APPLICATIONS OF GLUCAM E-10
Glucam E-10 is used in Color Cosmetics
Glucam E-10 is used in Eye Area Skin Care Products
Glucam E-10 is used in Facial Care Products


Glucam E-10 is used in Hair Removal
Glucam E-10 is used in Hand Sanitizer
Glucam E-10 is used in Hand/Foot Care

Glucam E-10 is used in Intimate Cleansers
Glucam E-10 is used in Lip Care
Glucam E-10 is used in Mild Cleansers

Glucam E-10 is used in Shaving Products
Glucam E-10 is used in Sun Care
Glucam E-10 is used in Wipes


Glucam E-10 humectant is a mild humectant, film plasticizer and moisturizer.
Glucam E-10 is naturally derived and delivers moisture to the skin while reducing the tacky feel.
Glucam E-10 is an ethoxylated methyl glucose ether.

Glucam E-10 offers low irritation, gloss and smooth silky feel.
Glucam E-10 is a very effective freezing point depressant and does not interfere with foam properties.
Glucam E-10 is ideal for use in both rinse off and leave on skin care systems.

Glucam E-10 humectant is used in body lotions/creams/gels, body cleansing formulations, color cosmetics, hair removal, hand sanitizer and intimate & mild cleansers.
Also, Glucam E-10 is used in hand soaps, wipes, shaving & styling products, eye-, facial-, hand/foot-, lip- and sun care products.


SAFETY INFORMATION ABOUT GLUCAM E-10:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product




GLUCAM E-20
DESCRIPTION:

Glucam E-20 humectant is a naturally-derived, multi-functional, mild ingredient that delivers a light, satin-like emollient feel in moisturizing systems.
Glucam E-20 is an ethoxylated methyl glucose ether and is 100% active.
Its low irritation potential makes it ideal for sensitive skin formulations.



Ingredient Name: Methyl Gluceth-20

In addition, Glucam E-20 humectant helps prevent soap bars from cracking and acts as a process aid in soap bar extrusion.
Glucam E-20 humectant is used in color cosmetics, hand sanitizer, intimate & mild cleansers, shampoos and wipes.
Also, used in shaving & styling products, eye-, facial-, hand/foot-, lip- and sun care products.




FEATURES/BENEFITS OF GLUCAM E-20
Glucam E-20 Improves flow property in cleansing applications
Glucam E-20 has Liquid form for ease of processing
Glucam E-20 has Low irritation potential and is ideal for use in products for sensitive skin

Glucam E-20 is Naturally derived
Glucam E-20 Provides a light, smooth skin feel
Glucam E-20 Reduced defatting of the skin
Glucam E-20 Reduces tacky feel of formulations containing high levels of glycerine


Applications of Glucam E-20:
Glucam E-20 is used in Body Washes
Glucam E-20 is used in Facial Cleansers
Glucam E-20 is used in Hand Soap


Glucam E-20 is used in Hand/Foot Care
Glucam E-20 is used in Intimate Cleansers
Glucam E-20 is used in Lip Care

Glucam E-20 is used in Mild Cleansers
Glucam E-20 is used in Shaving Products
Glucam E-20 is used in Styling Products

Glucam E-20 is used in Sun Care
Glucam E-20 is used in Wipes
Glucam E-20 humectant is a naturally-derived, multi-functional, mild ingredient that delivers a light, satin-like emollient feel in moisturising systems.


Glucam E-20 can be used in both rinse-off and leave-on skin care systems such as lotions, creams and body cleansing formulations like soap




SAFETY INFORMATION ABOUT GLUCAM E-20:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



GLUCAM E-20 HUMECTANT

Glucam E-20 humectant is a brand name for a chemical compound known as Methyl Gluceth-20.
Glucam E-20 humectant is a water-soluble, nonionic humectant and emollient derived from natural, renewable resources.
Specifically, Glucam E-20 humectant is an ester of methyl glucose and ethyl alcohol.
Glucam E-20 humectant is commonly used in the cosmetic and personal care industry for its moisturizing properties.

CAS Registry Number: 68815-73-0
EC Number: 271-616-1

Methyl Gluceth-20, Glucam E-20, Ethanol, 2-(2-hydroxyethylamino)-2-(hydroxymethyl)-, methyl deriv., Methyl glucoside, ethoxylated, Polyethylene glycol ether of methyl glucoside, Ethanol, 2-((2-hydroxyethyl)amino)-2-(hydroxymethyl)-, monomethyl ether, PEG-20 methyl glucose distearate, Methyl glucoside, polyoxyethylene ether, Methyl glucose ether, Methyl glucose polyoxyethylene ether, Methyl glucose distearate, 2-Hydroxyethyl methyl glucose ether, Methyl glucose dioleate, PEG-20 methyl glucose, Methyl glucoside, ethoxylated, monoether with ethanol, Ethanol, 2-(2-hydroxyethylamino)-2-(hydroxymethyl)-, methyl ether, Poly(oxy-1,2-ethanediyl), alpha-((2-hydroxyethyl)amino)-omega-((hydroxymethyl)oxy)-, monomethyl ether, Polyethylene glycol (20) methyl glucose distearate, Methyl glucoside 20, Ethanol, 2-((2-hydroxyethyl)amino)-2-(hydroxymethyl)-, monomethyl ether, Ethanol, 2-((2-hydroxyethyl)amino)-2-(hydroxymethyl)-, methyl ether, 2-((2-Hydroxyethyl)amino)-2-(hydroxymethyl)ethanol, methyl ether, Methyl glucoside 20 stearate, PEG-20 methyl glucose sesquistearate, Methyl glucose 20 stearate, Methyl glucoside 20 sesquistearate, Methyl glucoside 20 distearate, PEG-20 methyl glucose distearate, Ethanol, 2-((2-hydroxyethyl)amino)-2-(hydroxymethyl)-, methyl derivative, Methyl glucose 20 distearate, Poly(oxy-1,2-ethanediyl), alpha-((2-hydroxyethyl)amino)-omega-((hydroxymethyl)oxy)-, monomethyl ether, Methyl glucoside 20 monostearate, Methyl glucoside 20 sesquistearate, Methyl glucoside 20 monooleate, Methyl glucose polyoxyethylene stearate, Methyl glucose polyoxyethylene sesquistearate, Methyl glucoside 20 monooleate, PEG-20 methyl glucose distearate, Ethanol, 2-((2-hydroxyethyl)amino)-2-(hydroxymethyl)-, methyl ether, Poly(oxy-1,2-ethanediyl), alpha-((2-hydroxyethyl)amino)-omega-((hydroxymethyl)oxy)-, monomethyl ether, Polyethylene glycol (20) methyl glucose distearate, Polyethylene glycol methyl glucose distearate, Methyl glucoside 20 stearate, Polyethylene glycol (20) methyl glucose sesquistearate, Methyl glucoside 20 distearate, Poly(oxy-1,2-ethanediyl), alpha-((2-hydroxyethyl)amino)-omega-((hydroxymethyl)oxy)-, monomethyl ether, Methyl glucoside 20 monostearate, Methyl glucoside 20 sesquistearate, Methyl glucoside 20 monooleate, Methyl glucose polyoxyethylene stearate



APPLICATIONS


Glucam E-20 humectant finds widespread use in moisturizers, offering enhanced hydration to the skin.
Glucam E-20 humectant is a key ingredient in lotions, contributing to the smooth and non-greasy texture of the formulation.
Due to its water-soluble nature, Glucam E-20 humectant is a preferred choice in aqueous skincare products such as creams.
Glucam E-20 humectant is incorporated into serums to improve the absorption and efficacy of active ingredients.

Glucam E-20 humectant is a staple in facial cleansers, promoting hydration without leaving a heavy residue.
Its compatibility with various cosmetic ingredients makes it versatile in formulating different products.

In haircare, it is used in conditioners to provide a softening effect and improve manageability.
Shampoos often include Glucam E-20 humectant for its moisturizing benefits on both the scalp and hair.
Glucam E-20 humectant contributes to the emollient properties of cosmetic formulations, enhancing the skin's feel.

Its stability makes it a valuable component in skincare products with a longer shelf life.
Glucam E-20 humectant is employed in sunscreens, helping to maintain skin hydration under sun exposure.
Glucam E-20 humectant is used in makeup removers, ensuring effective cleansing without overly drying the skin.

Glucam E-20 humectant is found in after-sun products, soothing and moisturizing the skin post-sun exposure.
In body washes and shower gels, it promotes a refreshing and hydrating cleansing experience.
Glucam E-20 humectant is utilized in anti-aging formulations, contributing to the overall skin revitalization process.

Glucam E-20 humectant is a common ingredient in baby care products, providing gentle and moisturizing effects.
Glucam E-20 humectant's non-greasy nature makes it suitable for inclusion in various cosmetic and personal care items.
Glucam E-20 humectant is applied in hand creams, offering moisturization without a heavy or sticky feel.
Its compatibility with fragrances makes it suitable for use in scented cosmetic formulations.

Glucam E-20 humectant is found in facial masks, contributing to the hydrating and rejuvenating effects of such products.
Glucam E-20 humectant is used in pre-shave and aftershave products to soothe and moisturize the skin.
Glucam E-20 humectant is present in bath products, enhancing the overall skin-feel during and after bathing.

In deodorants, it helps maintain skin hydration while allowing for effective odor control.
Glucam E-20 humectant is a valuable component in cosmetic wipes, providing a moisturizing effect during use.
Glucam E-20 humectant is included in various personal care items, ranging from hand sanitizers to intimate hygiene products, due to its gentle and moisturizing properties.

Found in exfoliating scrubs, Glucam E-20 humectant aids in preventing excessive dryness by maintaining skin hydration.
Glucam E-20 humectant plays a role in facial toners, contributing to a refreshing and moisturizing post-cleansing experience.
Glucam E-20 humectant is incorporated into makeup foundations, providing a smooth and hydrating base for cosmetics.

In anti-acne formulations, it assists in preventing over-drying while delivering targeted skincare benefits.
Glucam E-20 humectant is used in intimate hygiene products, promoting gentle cleansing without compromising moisture.

Glucam E-20 humectant is a common ingredient in lip care products, contributing to their emollient and moisturizing properties.
Glucam E-20 humectant is found in hair styling products, helping to maintain a soft and manageable texture without greasiness.
Glucam E-20 humectant is utilized in body scrubs, ensuring exfoliation without stripping the skin of essential moisture.

In foot care products, it aids in preventing dryness and contributes to the overall moisturization of the skin.
Glucam E-20 humectant is included in shaving creams, offering a hydrating and smooth application for a comfortable shave.
Glucam E-20 humectant is applied in eye creams, contributing to the reduction of dryness and fine lines around the eyes.

Glucam E-20 humectant is used in nail care products, providing moisture to the cuticles and surrounding skin.
In sunless tanners, Glucam E-20 humectant contributes to a smoother and more even application of the product.
Found in body mists, it enhances the overall sensory experience by providing a lightweight and moisturizing mist.
Glucam E-20 humectant is employed in leave-in hair conditioners, contributing to detangling and softening effects.

In hand sanitizers, it helps counteract the drying effects of alcohol, maintaining skin comfort.
Glucam E-20 humectant is included in BB creams and CC creams, contributing to their hydrating and skin-perfecting properties.

Glucam E-20 humectant is used in natural and organic cosmetic formulations, aligning with the demand for sustainable ingredients.
In personal lubricants, it contributes to a smooth and moisturizing texture for enhanced comfort.

Glucam E-20 humectant is applied in wound care products, providing a gentle and hydrating environment for healing.
Found in hair masks, it contributes to deep conditioning and moisturizing effects for improved hair health.
In gel-based skincare products, it aids in maintaining a lightweight and non-sticky texture.

Glucam E-20 humectant is used in tinted moisturizers, offering hydration with a subtle tint for a natural look.
Glucam E-20 humectant is included in facial primers, providing a smooth base for makeup application while keeping the skin hydrated.
Glucam E-20 humectant is applied in baby wipes, contributing to their gentle and moisturizing characteristics.

Found in body lotions, Glucam E-20 humectant enhances the overall skin-feel by providing lasting hydration.
Glucam E-20 humectant is a common ingredient in nighttime moisturizers, supporting skin replenishment and hydration during sleep.
In facial mists, Methyl Gluceth-20 contributes to a refreshing burst of hydration throughout the day.

Glucam E-20 humectant is applied in bath bombs, adding a moisturizing element to the effervescent and aromatic experience.
Glucam E-20 humectant is included in soothing gels, providing relief to irritated or sun-exposed skin.
In anti-redness creams, it helps calm and moisturize sensitive skin, reducing the appearance of redness.

Glucam E-20 humectant is utilized in scalp treatments, contributing to a balanced and moisturized scalp environment.
Glucam E-20 humectant is incorporated into makeup setting sprays, helping to set makeup while providing hydration.
In under-eye creams, it aids in reducing puffiness and dryness for a refreshed appearance.
Glucam E-20 humectant is found in foaming cleansers, ensuring effective cleansing without stripping the skin of essential moisture.

Glucam E-20 humectant is used in hand masks, providing an intensive moisturizing treatment for dry and stressed hands.
Glucam E-20 humectant is applied in post-shave balms, contributing to the soothing and moisturizing effects on the skin.
Glucam E-20 humectant is included in foot masks, helping to soften and hydrate rough and calloused skin.
In lip masks and treatments, it assists in preventing chapping and maintaining lip moisture.

Glucam E-20 humectant is utilized in cooling gels, offering a refreshing and hydrating sensation to the skin.
Glucam E-20 humectant is applied in facial powders, contributing to a lightweight and non-drying formula.

Found in primer sprays, it helps create a smooth canvas for makeup application while keeping the skin hydrated.
Glucam E-20 humectant is included in tinted lip balms, providing a hint of color along with moisturizing benefits.
Glucam E-20 humectant is used in gel-based sunscreen formulations, ensuring a light and comfortable application.
In exfoliating masks, it aids in preventing excessive dryness and maintaining skin hydration.
Glucam E-20 humectant is applied in cuticle oils, contributing to the softening and moisturizing of nail cuticles.

Glucam E-20 humectant is used in gel-based deodorants, providing a hydrating and comfortable application.
Found in facial essence products, it supports hydration and prepares the skin for subsequent skincare steps.

Glucam E-20 humectant is included in body balms, contributing to intensive moisturization for dry skin areas.
In cooling eye patches, it enhances the soothing and hydrating effects on tired and puffy eyes.



DESCRIPTION


Glucam E-20 humectant is a brand name for a chemical compound known as Methyl Gluceth-20.
Glucam E-20 humectant is a water-soluble, nonionic humectant and emollient derived from natural, renewable resources.
Specifically, Glucam E-20 humectant is an ester of methyl glucose and ethyl alcohol.
Glucam E-20 humectant is commonly used in the cosmetic and personal care industry for its moisturizing properties.

Methyl Gluceth-20, also known as Glucam E-20, is a water-soluble compound derived from natural sources.
Glucam E-20 humectant and emollient is widely used in cosmetic formulations for its moisturizing properties.

Glucam E-20 humectant is an ester of methyl glucose and ethyl alcohol, making it biodegradable and environmentally friendly.
As a polyoxyethylene ether of methyl glucoside, it exhibits excellent water solubility.
Glucam E-20 humectant is recognized for its ability to attract and retain moisture, contributing to enhanced hydration in skincare products.

Glucam E-20 humectant imparts a non-greasy, smooth feel to the skin, making it suitable for various cosmetic applications.
Glucam E-20 humectant is commonly employed in lotions, creams, and serums to improve overall texture and skin feel.
Being compatible with a range of cosmetic ingredients, it offers versatility in formulation design.

Glucam E-20 humectant is derived from glucose, aligning with the industry's emphasis on sustainable and renewable resources.
Its ester structure and polyoxyethylene chain contribute to its emollient properties.

Glucam E-20 humectant is known for its stability in formulations, helping to maintain the integrity of cosmetic products.
Due to its water solubility, it is easily incorporated into aqueous formulations without compromising stability.

Glucam E-20 humectant is used in haircare products like conditioners and shampoos for its moisturizing effects on hair.
Glucam E-20 humectant is often chosen for formulations where a lightweight and non-oily texture are desired.
Its safety for use in cosmetics is supported by adherence to recommended usage levels and regulatory standards.

Glucam E-20 humectant contributes to the sensory appeal of products, providing a pleasant and moisturized skin feel.
As a polyoxyethylene ether, it exhibits excellent compatibility with surfactants and other cosmetic ingredients.

Glucam E-20 humectant is effective in stabilizing formulations, extending the shelf life of cosmetic products.
Its use in cleansers helps to maintain skin hydration while ensuring a non-greasy after-feel.
Glucam E-20 humectant is known for its biodegradability, aligning with the industry's focus on environmentally conscious practices.
Glucam E-20 humectant is an ingredient of choice for formulators aiming to create hydrating and lightweight skincare solutions.
Due to its non-ionic nature, it interacts well with various skin types, making it suitable for a broad range of consumers.

Its incorporation in serums enhances the penetration of active ingredients into the skin for improved efficacy.
Glucam E-20 humectant's versatility extends to its application in haircare formulations, contributing to soft and manageable hair.
Glucam E-20 humectant plays a role in enhancing the overall user experience in cosmetic and personal care products.



FIRST AID


Inhalation:

If inhalation of vapor or mist occurs, move the affected person to fresh air.
If respiratory irritation persists, seek medical attention.


Skin Contact:

In the event of skin contact, wash the affected area thoroughly with mild soap and water.
Remove contaminated clothing if necessary.
If irritation or redness persists, seek medical advice.


Eye Contact:

In case of eye contact, flush the eyes gently with lukewarm water for at least 15 minutes, holding the eyelids open.
Seek immediate medical attention if irritation persists.


Ingestion:

If Methyl Gluceth-20 is ingested, do not induce vomiting unless instructed by medical professionals.
Rinse the mouth with water if the product has been swallowed.
Seek medical attention immediately.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
When handling Methyl Gluceth-20, use appropriate PPE, including gloves and safety goggles, to minimize direct skin and eye contact.

Ventilation:
Work in a well-ventilated area or use local exhaust ventilation to control exposure to vapors or mists, especially in cases where aerosolization may occur.

Avoidance of Contact:
Avoid direct skin contact with undiluted Methyl Gluceth-20.
In case of contact, wash the affected area promptly with mild soap and water.

Incompatibilities:
Ensure compatibility with other ingredients in formulations.
Follow compatibility guidelines provided by suppliers to prevent undesirable reactions.

Spill Response:
In the event of a spill, absorb the material with an inert absorbent and dispose of it according to local regulations.

Waste Disposal:
Dispose of Methyl Gluceth-20 and associated materials in accordance with local regulations.
Follow guidelines for waste disposal provided by regulatory authorities.

Storage Temperature:
Store Methyl Gluceth-20 in a cool, dry place.
Avoid exposure to excessive heat or direct sunlight, as this may affect the stability of the product.

Container Integrity:
Ensure that containers used for storage are tightly sealed to prevent contamination and evaporation of the product.

Handling Procedures:
Follow good manufacturing practices (GMP) and standard operating procedures (SOPs) for handling cosmetic ingredients.
Train personnel on proper handling techniques.


Storage:

Temperature:
Store Methyl Gluceth-20 at temperatures recommended by the supplier.
Typically, room temperature or slightly cooler conditions are suitable.

Ventilation:
Ensure storage areas are well-ventilated to prevent the buildup of vapors or mists.

Avoidance of Contaminants:
Store Methyl Gluceth-20 away from potential contaminants, such as strong odors, incompatible materials, and substances that may react with the product.

Original Containers:
Preferably, store Methyl Gluceth-20 in its original packaging to maintain product integrity and ensure proper labeling.

Controlled Access:
Restrict access to storage areas to authorized personnel only.
Keep the product out of reach of unauthorized individuals.

Separation from Incompatibles:
Store Methyl Gluceth-20 away from incompatible materials, including strong acids, bases, and oxidizing agents.

Monitoring Conditions:
Regularly monitor storage conditions to ensure they comply with the supplier's recommendations and regulatory requirements.

Labeling:
Clearly label storage areas with appropriate hazard information and handling instructions.
Ensure labels are intact and legible.

Emergency Procedures:
Have emergency procedures in place, including contact information for relevant emergency services, in case of accidental exposure, spills, or other emergencies.
GLUCAM P 10
DESCRIPTION:
Glucam P 10 humectant is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P 10 creates a luxurious feel in shampoos and other surfactant systems.
Its mildness makes Glucam P 10 a natural choice for makeup products used around the eye or in formulations made for sensitive skin.


CAS Number: 61849-72-7
Function: Humectant / Sensory Modifier / Solubilizer
INCI Name: PPG-10 Methyl Glucose Ether



CHEMICAL AND PHYSICAL PROPERTIES OF GLUCAM P 10:
Molecular Weight: 730.88450000
Formula: C31 H70 O18
CAS Number: 61849-72-7
Function: Humectant / Sensory Modifier / Solubilizer
INCI Name: PPG-10 Methyl Glucose Ether
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 389.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 372.00 °F. TCC ( 189.10 °C. ) (est)
logP (o/w): -2.690 (est)
Boiling Point:389.1 °C at 760 mmHgFlash Point:189.1 °C
Vapor Pressure:1.15E-07mmHg at 25°C



Glucam P 10 is recommended for use in lotions, creams, cleansing formulations, hair conditioners, styling gels, and mousses.
Glucam P 10 offers excellent shine & gloss, improves combability & solubility.
Glucam P 10 increases foam wetness and provides smooth, silky feel.

Moreover, Glucam P 10 reduces sting of hydroalcoholic systems.
Glucam P 10 humectant is used in color cosmetics, hand soaps, wipes, intimate & mild cleansers.
Also, Glucam P 10 is used in eye-, facial-, hand/foot- and sun care products.
Glucam P 10 has the special property of reducing the viscosity of surface-active agents and of foaming effect.




SAFETY INFORMATION ABOUT GLUCAM P 10:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.


SYNONYMS OF GLUCAM P 10:
GLUCAM P-10/20
PPG-20 METHYL GLUCOSE ETHER
Polyoxy(methyl-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, ether with methyl .beta.-D-glucopyranoside (4:1)
Poly(oxy(methyl-1,2-ethandiyl)), alpha-hydro-omega-hydroxy-, Ether mit Methyl-beta-D-glucopyranosid (4:1)
B-Methyl D-glucopyranoside, propoxylated
Poly[oxy(methyl-1,2-ethanediyl)], α-hydro-ω-hydroxy-, ether with methyl -D-glucopyranoside (4:1)
Methyl glucoside propoxylate
Polypropylene glycol beta-methyl glucoside ether (4:1)



GLUCAM P 20
DESCRIPTION:
GLUCAM P 20 humectant is a naturally-derived, 100% active, propoxylated methyl glucose ether.
GLUCAM P 20 is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.
In any product, GLUCAM P 20 delivers humectancy with a lubricious, emollient feel.

CAS # 61849-72-7
Function: Humectant
INCI Name: PPG-20 Methyl Glucose Ether


CHEMICAL AND PHYSICAL PROPERTIES OF GLUCAM P 20 :
INCI Name: PPG-20 Methyl Glucose Ether
Function: Humectant
Ingredient Origin: Natural Origin
Labeling Claims: GMO-free, TSE-free, Natural, Halal, Naturally Derived
Certifications & Compliance: Halal, CFDA Compliant (China)
Benefit Claims: Reduces Freezing Point Depression, Cleansing, Luxurious Skin-Feel, Fixative, Emolliency, Reduces Stinging, Humectancy
Molecular Weight: 730.88450000
Formula: C31 H70 O18
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 389.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 372.00 °F. TCC ( 189.10 °C. ) (est)
logP (o/w): -2.690 (est)


In alcohol-based systems Glucam P-20 humectant reduces the stinging effect alcohol has on skin.
Equally important in fragrance containing formulations, GLUCAM P 20 acts as a fixative by subduing volatilization of the "high notes".

The light color and low odor of Glucam P-20 humectant will not interfere with the mood the fragrance is trying to communicate.
GLUCAM P 20 is recommended for use in hair care and skin care products.

GLUCAM P 20 humectant is a naturally-derived, 100% active, propoxylated methyl glucose ether.
GLUCAM P 20 is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.
In any product, GLUCAM P 20 delivers humectancy with a lubricious, emollient feel.

In alcohol-based systems GLUCAM P 20 humectant reduces the stinging effect alcohol has on skin.
Equally important in fragrance containing formulations, GLUCAM P 20 acts as a fixative by subduing volatilization of the "high notes".
The light color and low odor of GLUCAM P 20 humectant will not interfere with the mood the fragrance is trying to communicate.
GLUCAM P 20 is recommended for use in hair care and skin care products.

CTFA/INCI Designation: PPG-20 Methyl Glucose Ether
Typical Properties: Physical properties are listed below and indicate typical values and properties; they are not intended to be used as product specifications.
Solubility: Water, alcohols, organic esters and oils
Reduces stinging of alcohol


FEATURES/BENEFITS OF GLUCAM P 20:
GLUCAM P 20 has Fragrance fixation
GLUCAM P 20 has Freezing point depressant
GLUCAM P 20 is Luxurious feel

GLUCAM P 20 is Miscible with water, alcohols, organic esters and oils
GLUCAM P 20 is Naturally derived
GLUCAM P 20 Reduces stinging of alcohol

GLUCAM P 20 is Efficient barrier for reducing water loss from the stratum corneum while allowing some water transport
GLUCAM P 20 Helps eliminate the heavy, greasy feeling normally associated with superior moisturization
GLUCAM P 20 is Light, smooth, non-greasy feel
GLUCAM P 20 Provides luxurious slip properties to creams and lotions


GLUCAM P 20 is a hygroscopic propylated methyl glucose ether of natural origin with dissolving properties.
GLUCAM P 20 has light color and indinstict odor .
GLUCAM P 20 is used as an emollient or lubricant.

GLUCAM P 20 also acts as a perfume stabilizer, by decreasing its volatility.
When added to products containing ethyl alcohol, GLUCAM P 20 reduces the stinging sensation it causes.
GLUCAM P 20 is Suitable for use in dermocosmetics and hair products.


APPLICATIONS OF GLUCAM P 20:
GLUCAM P 20 is used in Shaving Products
GLUCAM P 20 is used in Styling Products

GLUCAM P 20 distearate emollient is a naturally-derived 100% active, propoxylated methyl glucose ether.
GLUCAM P 20 is designed for skin care formulations to deliver safe, effective moisturization without a heavy-, greasy feel.
Because GLUCAM P 20 is mild, vegetable-derived and non-comedogenic, GLUCAM P 20 is especially well suited for products used around the eye or in formulations made for sensitive skin.




SAFETY INFORMATION ABOUT GLUCAM P 20 :
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.






GLUCAM P20
Glucam P20 may have humectant properties, helping to retain moisture and keep the skin or hair hydrated.
Glucam P20 is often used to improve the texture and feel of cosmetic products, making them more pleasant to use.
Glucam P20 is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.

CAS Number: 61849-72-7
Molecular Formula: C31H70O18
Molecular Weight: 730.8767

Glucam P20, (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol;2-(2-hydroxypropoxy)propan-1-ol.

Glucam P20 is currently not a stock item, it may not be available at the moment.
Glucam P20 is a humectant and emollient added to many personal care products.
Derived from glucose and plant-based oils, it is a clear, and colorless liquid that is largely soluble in water.

Glucam P20 is known for its ability to improve the texture of skincare and haircare products, making them smoother and more spreadable.
However, our global sourcing specialists can support in line with your product specification and your preferences.
Glucam P20 also helps to fix fragrance. We also supply other cosmetic materials.

Glucam P20 acts as a surfactant, helping to reduce the surface tension of liquids.
This property allows the product to spread more easily on the skin or hair.
Glucam P20 can function as an emollient, contributing to the softening and smoothing of the skin or hair.

Glucam P20 delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems it reduces the stinging effect alcohol has on skin.
Glucam P20 distearate emollient is a naturally-derived 100% active, propoxylated methyl glucose ether.

Glucam P20 is designed for skin care formulations to deliver safe, effective moisturization without a heavy, greasy feel.
Because Glucam P20 is mild, vegetable-derived and non-comedogenic, it is especially well suited for products used around the eye or in formulations made for sensitive skin.
In hair care products, Glucam P20 acts as a humectant, helping to retain moisture and prevent dryness.

This helps keep hair feeling soft, smooth, and hydrated.
Glucam P20 also aids in moisturizing and soothing the skin, leaving it feeling nourished.
Glucam P20 has a smoothing effect on the skin, which makes it a popular ingredient in anti-aging formulations.

Glucam P20 can be found in shampoos, conditioners, lotions, and creams, and is often used in combination with other ingredients to enhance its benefits.
Glucam P20 indicated, in 2009, as being intended to be registered by at least one company in the EEA.
Such notifications are required for hazardous substances, as such or in mixtures, as well as for all substances subject to registration, regardless of their hazard.

Glucam P20 comes as a pale yellow, medium-viscosity liquid in its raw material form and is obtained from corn.
Glucam P20 is a polyethylene glycol ether of the mono anddiesters of methyl glucose and stearic acid with an average of 20 moles of ethylene oxide.
Glucam P20 is a mild, water-loving emulsifier that's safe for sensitive skin or eye-care formulations.

Glucam P20 helps to create low viscosity oil-in-water emulsions, ideal for milks, serums, and sprayable formulations.
Glucam P20's derived from natural sources and gives a light, satiny afterfeel.
Glucam P20 is naturally derived emollient that provides hydration without a heavy, greasy feel.

Glucam P20 is a naturally derived 100% active propoxylated methyl glucose ether.
Designed for skin care formulations to provide safe, effective hydration without a heavy, greasy feel.
Since Glucam P20 is mild, plant-based and non-comedogenic, it is very suitable for products used especially around the eyes or formulations prepared for sensitive skin.

Glucam P20 is the ether of mono and diester of methyl glucose and stearic acid.
Glucam P20 is a yellowish paste with a characteristic odor.
Glucam P20 is a combination of both polyethelene glycol – a water-loving molecule and stearic acid – a fat-loving molecule.

Glucam P20 is a glucose molecule having a methyl group attached by displacing a hydrogen atom.
Glucam P20 can be considered as a bulky molecule having surfactant like properties.

Glucam P20 is an ethoxylated methyl glucose ether which has been esterified with stearic acid.
Glucam P20 is 100% active and is supplied as a soft solid.
Glucam P20 has water-in-oil emulsifying activity, and Glucamate SSE-20 emulsifier is an oil-in-water emulsifier

Glucam P20 is used together, they form a complementary pair offering safety and performance advantages over more conventional emulsifiers.
With extremely low eye irritation scores, these ingredients are perfect for creams, lotions and makeup used near the eye.
Glucam P20 is used in beauty products and cosmetics as both an emollient and surfactant.

Glucam P20 is the polyethylene glycol ether of the mono and diesters of Methyl Glucose and Stearic Acid, and is minimally absorbed by skin because of
Glucam P20 is seen as an ingredient in a large number of products because of their diverse properties

Glucam P20 also helps to moisturize the surface that it is applied on and lock in hydration, leaving the surface feeling soft and supple.
Glucam P20 is known for its ability to improve the texture of skincare and haircare products, making them smoother and more spreadable.
Glucam P20 is a humectant and emollient added to many personal care products

According to suppliers of Glucam P20, it comes as a pale yellow, medium-viscosity liquid in its raw material form and is obtained from corn.
Glucam P20 is a blend of polypropylene glycol and methyl glucose derivatives that helps soften and smooth skin and hair.
Glucam P20 is considered an excellent hydrating ingredient due to its humectant (water-binding) properties.

Glucam P20 is sometimes used to enhance the texture of cosmetic formulas.
Glucam P20 also helps to moisturize the surface that it is applied on and lock in hydration, leaving the surface feeling soft and supple.
Glucam P20 is a Diester of PPG20 methyl glucose ether and stearic acid Glucam P20 distearate uses and applications include: Humectant, moisturizer, conditioner, and emollient for cosmetics and pharmaceuticals; binder and plasticizer for pressed powders.

Glucam P20 is one of the few naturally derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.
In any product, Glucam P20 delivers humectancy with a lubricious, emollient feel.
Glucam P20 is a mild, non-irritative moisturizer derived from natural glucose.

Glucam P20 can be mixed with water, alcohol and grease, providing favorable moisturization, lubricity and emollience.
Glucam P20’s widely used in skin care, hair care and body wash products, reducing irritation to skin caused by alcohol.
The chemical formula for Glucam P20 is C31H70O18.

Glucam P20 is a very useful ingredient that is commonly used in personal care products.
Glucam P20 has moisturizing and emollient properties that are beneficial for hair and skin formulations.
In hair care products, Glucam P20 acts as a humectant, helping to retain moisture and prevent dryness.

This helps keep hair feeling soft, smooth, and hydrated.
Glucam P20 also aids in moisturizing and soothing the skin, leaving it feeling nourished.
Glucam P20 has a smoothing effect on the skin, which makes it a popular ingredient in anti-aging formulations.

Glucam P20 can be found in shampoos, conditioners, lotions, and creams, and is often used in combination with other ingredients to enhance its benefits.
Glucam P20 is a cosmetic ingredient commonly used in skincare and hair care products.
Glucam P20 is made by combining plant-based oils and glucose.

The process involves the reaction of the oils with glucose to form a complex mixture of esters.
This mixture is then further processed to produce the final ingredient.
Glucam P20 humectant is a naturally-derived, 100% active, propoxylated methyl glucose ether.

Glucam P20 is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.
In any product, it delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems Glucam P-20 humectant reduces the stinging effect alcohol has on skin.

Equally important in fragrance containing formulations, it acts as a fixative by subduing volatilization of the "high notes".
The light color and low odor of Glucam P-20 humectant will not interfere with the mood the fragrance is trying to communicate.
Glucam P20 is recommended for use in hair care and skin care products.

Derived from glucose and plant-based oils, Glucam P20 is a clear, and colorless liquid that is largely soluble in water.
The chemical formula for Glucam P20 is C31H70O18.
Glucam P20 is a very useful ingredient that is commonly used in personal care products.

Glucam P20 has moisturizing and emollient properties that are beneficial for hair and skin formulations.
Glucam P20 is used as wetting agent, skin caring agent, emulsifying agent and fixative.
Glucam P20 is mixing soluble with polar solvents, as water and ethyl alcohol and also with nonpolar solvents, for example, isopropyl palmitate.

LogP: -2.690 (est)
EWG's Food Scores: 1

In alcohol-based systems GlucamP20 humectant reduces the stinging effect alcohol has on skin.
As a skin conditioning agent, Glucam P20 forms a protective film on the skin surface that prevents moisture loss from the skin and lubricates it.
When used on the hair, it forms a protective layer on the hair and prevents it from drying out.

Glucam P20 gives it a smooth and silky look.
Depending on its chemical structure, Glucam P20 also functions as an emollient and surfactant in cosmetic products.
A surfactant is one that works more or less like a detergent.

Chemically, ether (-O-), which is the binding link between PPG and methylglucose, imparts a loving characteristic to fat, while PPG and methylglucose, separately, are loving. of water by nature.
Therefore, when combined, they are effective against dirt and dead bacteria, since they are grease-loving.
They stick to dirt and bacteria on the skin and wash away with water.

Both PPG and methylglucose have some functional groups that attract water and hold it for use by skin cells.
Glucam P20 can contribute to the hydration of the skin and hair.
Glucam P20 is humectant properties help attract and retain moisture, promoting a smoother and more moisturized appearance.

In addition to skincare and hair care products, Glucam P20 is often used in cleansers and foaming products.
Glucam P20 is surfactant properties make it useful for creating a lathering effect, helping to cleanse the skin or hair effectively.
Glucam P20 can contribute to the stability of formulations by preventing the separation of oil and water phases in emulsions.

This enhances the overall stability and shelf life of cosmetic products.
As a non-ionic surfactant, Glucam P20 is generally considered mild and is less likely to cause irritation compared to some other surfactants.
This makes it suitable for use in products designed for sensitive skin.

The presence of a polyol structure (methyl glucose) in the molecule can add a conditioning effect, contributing to the softness and manageability of hair in hair care formulations.
Glucam P20 is recommended for use in perfume, fabcon, linen spray, hair care and skin care products.
Glucam P20 can also be used as humectants to your skin care products like lotion and cream.

Glucam P20 is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.
Glucam P20 delivers humectancy with a lubricious, emollient feel.
Glucam P20 is used in formulations of creams, lotions, moisturizers, conditioners, and other skin and hair care products.

Glucam P20 can contribute to the viscosity control of cosmetic formulations.
Glucam P20 helps to adjust the thickness or flow of the product, which is crucial for various formulations such as creams, lotions, and gels.
In some formulations, Glucam P20 may be used in combination with other ingredients to create synergistic effects.

Glucam P20 can enhance the overall performance and sensory attributes of the product.
This ingredient is often compatible with a wide range of other cosmetic ingredients, making it versatile in formulating different types of personal care products.
Glucam P20 is non-ionic, meaning it does not carry an electric charge.

This makes it compatible with a variety of cosmetic formulations, including those that are sensitive to changes in pH.
Cosmetic manufacturers often use Glucam P20 to improve the sensory experience of their products.
The ingredient can contribute to a luxurious feel, ease of application, and a non-sticky finish, which positively influences consumer perception.

Glucam P20 is a blend of polypropylene glycol and methyl glucose derivatives that helps soften and smooth skin and hair.
Glucam P20 is considered an excellent hydrating ingredient due to its humectant (water-binding) properties.
Glucam P20 is sometimes used to enhance the texture of cosmetic formulas.

In alcohol-based systems Glucam P20 reduces the stinging effect alcohol has on skin.
Equally important in fragrance containing formulations, it acts as a fixative by subduing volatilization of the "high notes"
Glucam P20 is a synthetic polymer of propylene oxide.

In cosmetics, PPG is often used to enhance the texture and feel of products, providing a smooth and silky consistency.
Glucam P20 is derived from glucose and is often used in cosmetic formulations for its ability to condition and moisturize the skin.
Glucam P20 can also act as a humectant, helping to retain moisture.

Glucam P20 contributes to the emollient properties of skincare and hair care products.
Emollients are substances that help to soften and smooth the skin, improving its texture and appearance.
As a surfactant, Glucam P20 helps to reduce the surface tension of liquids, aiding in the even distribution of the product and enhancing its spreadability.

Glucam P20 is water-soluble, making it suitable for a wide range of formulations, including aqueous solutions like lotions and shampoos.
This ingredient is often chosen for its stability in formulations, contributing to the overall stability and shelf life of cosmetic products.

Glucam P20 functions as a hair and skin conditioning agent.
As a skin conditioning agent forms a protective film on the surface of the skin which prevents loss of moisture from the skin and lubricates it.
When used in hair it forms a protective layer on the hair and prevents it from drying.

Glucam P20 makes it appear soft and silky.
Depending upon the chemical structure Glucam P20 also functions as an emollient and surfactant in cosmetic products.
A surfactant is the one that more or less works like a detergent.

Chemically understanding, ether (-O-) being the connecting bond between PPG and Methyl glucose, imparts fat-loving characteristic, while PPG and methyl glucose, individually are water-loving in nature.
So, when they combine, they are effective against dirt and dead bacteria, since they are fat-loving.
They bond with dirt and bacteria present on the skin and get carried away with water. Both PPG and Methyl glucose have some functional groups that attract water and hold it for use for the skin cells.

So, it can function as emollient as well.
Glucam P20 is used in formulations of creams, lotions, moisturizers, conditioners, and other skin and hair care products.
As with any cosmetic ingredient, Glucam P20 is important to use products containing Glucam P20 as directed and discontinue use if any signs of irritation or allergic reaction occur.

Glucam P20 functions as a hair and skin conditioning agent.
Glucam P20 is a synthetic polymer formed from methyl glucose ether and polypropylene glycol.
The number represents the number of PPG units in the polymer chain.

Glucam P20 is light in color and soluble in oils and other organic solvents.
Glucam P20 is a blend of polypropylene glycol and methyl glucose derivatives that helps soften and smooth skin and hair.
Glucam P20 is considered an excellent hydrating ingredient due to its humectant (water-binding) properties.

Glucam P20 is sometimes used to enhance the texture of cosmetic formulas.
According to suppliers of Glucam P20, it comes as a pale yellow, medium-viscosity liquid in its raw material form and is obtained from corn.
Glucam P20 emollient is a naturally-derived 100% active, propoxylated methyl glucose ether.

Glucam P20 is designed for skin care formulations to deliver safe, effective moisturization without a heavy, greasy feel.
Because Glucam P20 is mild, vegetable-derived and non-comedogenic, it is especially well suited for products used around the eye or in formulations made for sensitive skin.
In fragrance containing formulations, Glucam P20 acts as a fixative by subduing volatilization of the "high notes".

The light color and low odor of Glucam P20 humectant will not interfere with the mood the fragrance is trying to communicate.
This is also a naturally-derived humectant, 100% active, propoxylated Glucam P20.

Glucam P20 is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.
In any product, it delivers humectancy with a lubricious, emollient feel.

Uses:
Glucam P20's solubility and mild characteristics make it suitable for use in fragrance formulations, helping to disperse and stabilize fragrance ingredients.
Glucam P20 reduces a chance of inter-reaction of various ingredients and gives noticeable stability to the product.
Glucam P20 also functions as a thickener by attracting water molecules and gives a sort of ‘swollen’ appearance to its molecule.

Glucam P20 enhances its overall performance of the product on the skin or hair surface.
Glucam P20 can be present in various grooming products for men, such as shaving creams and aftershaves, contributing to their texture and overall performance.

Glucam P20 may be included in sunscreen formulations to contribute to the overall texture and spreadability of the product.
Glucam P20 can enhance the user experience by providing a smoother application.
In facial serums, Glucam P20 can function as a lightweight emollient, helping to deliver active ingredients while providing a non-greasy feel.

Glucam P20 can be found in various makeup products such as foundations, BB creams, and tinted moisturizers.
Glucam P20 is emollient properties contribute to a smooth application and help create a desirable finish.
Glucam P20 is soothing and moisturizing properties make Glucam P20 suitable for inclusion in after-shave products, helping to calm and hydrate the skin post-shaving.

In pre-shave products like shaving creams or gels, Glucam P20 can contribute to the overall texture, making it easier for the product to adhere to the skin for a smoother shaving experience.
Glucam P20 may be used in body creams and body butters to enhance the moisturizing properties, providing a luxurious and soft feel to the skin.
Its water-soluble nature makes Glucam P20 suitable for use in antiperspirants and deodorants, contributing to the overall formulation and feel of the product.

Glucam P20's mild and conditioning properties make it suitable for use in baby care products, such as baby lotions or mild cleansers.
Glucam P20 is used for its emulsifying properties in cosmetic products.
As an emulsifier, Glucam P20 gives stability to the product and prevents the oil and water-based components of the product from getting separated.

Since molecules dissolving in water can take up the Glucam P20 part and oil dissolving molecules will get attached to the stearate part.
Glucam P20 is used in formulations of creams, lotions, gels, shampoos, and other skincare products.
Glucam P20 can be included in moisturizers and lotions to provide emollient properties, helping to soften and hydrate the skin.

Glucam P20 is surfactant properties make it suitable for use in facial cleansers, body washes, and other cleansing products, contributing to foaming and cleansing effects.
Glucam P20 may be added to hair conditioners to enhance the texture and manageability of the hair, providing a conditioning effect.
In shampoos, Glucam P20 can contribute to foaming and cleansing properties.

Glucam P20 helps stabilize emulsions, preventing the separation of oil and water phases.
This is important in formulations like creams and lotions.
Glucam P20 can be used to adjust the thickness or viscosity of cosmetic products, influencing their texture and application.

Glucam P20 acts as a humectant, attracting and retaining moisture, which is beneficial for maintaining skin and hair hydration.
Due to its non-ionic nature and mild characteristics, Glucam P20 is often included in formulations designed for sensitive skin.
Glucam P20 contributes to the overall sensory experience of a product, providing a smooth and pleasant texture.

Glucam P20 can be found in some sunscreen formulations, contributing to the overall texture of the product.
Glucam P20 is water-soluble nature makes it compatible with both water-based and oil-based sunscreen formulations.
In cosmetic products such as foundations, concealers, and BB creams, Glucam P20 may be used to enhance the spreadability and blendability of the product.

Glucam P20 is commonly used in various body care products, including body lotions, creams, and shower gels, where it can provide moisturizing and cleansing benefits.
Due to its mildness and moisturizing properties, Glucam P20 is sometimes included in formulations for baby care products such as baby lotions and washes.

Glucam P20 can be found in leave-in conditioners, hair serums, and styling products, contributing to the overall manageability and softness of the hair.
Glucam P20 may be included in the formulation of cosmetic wipes, contributing to the effectiveness of the wipe in removing makeup and impurities.

Safety profile:
Some individuals may be more sensitive to certain cosmetic ingredients, and skin irritation or allergic reactions could occur.
Glucam P20's always advisable to perform a patch test before using a new product extensively, especially if you have a history of skin allergies or sensitivities.
Avoid contact with eyes.

In case of accidental contact, rinse thoroughly with water.
While inhalation exposure is unlikely in typical cosmetic use, excessive inhalation of fine particles or aerosols should be avoided.
Glucam P20 is generally considered a safe ingredient for use in a variety of different products within the cosmetic industry.

Glucam P20 is well tolerated by most skin and hair types and is also non-comedogenic. Patch testing is not typically necessary for this ingredient.
Additionally, Glucam P20 is vegan and halal, making it a suitable ingredient for those following a vegan or halal lifestyle.
As with any cosmetic ingredient, it is important to use products containing Glucam P20 as directed and discontinue use if any signs of irritation or allergic reaction occur.

The safety of any cosmetic product depends on the entire formulation, including the combination of ingredients and their concentrations.
Always follow product usage instructions and guidelines provided by the manufacturer.



GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER)
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived 100% active, propoxylated methyl glucose ether.
The chemical formula for Glucam P-20 (PPG-20 Methyl Glucose Ether) is C31H70O18.


CAS Number: 61849-72-7
Chem/IUPAC Name: Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-hydro-.omega.-hydroxy-, ether with methyl .beta.-d-glucopyranoside (4:1)
Name: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol;2-(2-hydroxypropoxy)propan-1-ol (ppg-20)
MDL Number: MFCD08064623
Molecular Formula: C31H70O18



PPG-20 methyl glucose ether, 3WV1T97D3K, AEC PPG-20 METHYL GLUCOSE ETHER, GLUCAM P-20 HUMECTANT, MACBIOBRIDE MG-20P, METHYL GLUCOSIDE PROPOXYLATE (20), POLYOXYPROPYLENE (20) METHYL GLUCOSE ETHER, POLYPROPYLENE GLYCOL (20) METHYL GLUCOSE ETHER, Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, ether with methylbeta-D-glucopyranoside (4:1), Polypropylene glycol methyl beta-glucopyranoside ether (4:1), UNII-3WV1T97D3K, UNII-U8FDM41K9E, Methyl Glucoside Propoxylate, Polypropylene Glycol Methyl Glucose Ether, GLUCAM P-10/20, Methyl glucoside propoxylate, Polypropylene glycol beta-methyl glucoside ether (4:1), Polypropylene glycol methyl beta-glucopyranoside ether (4:1), alpha-Hydro-omega-hydroxy-poly[oxy(methyl-1,2-ethanediyl)] ether with methyl beta-D-glucopyranoside (4:1), Polyoxy(methyl-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, ether with methyl .beta.-D-glucopyranoside (4:1), Poly(oxy(methyl-1,2-ethandiyl)), alpha-hydro-omega-hydroxy-, Ether mit Methyl-beta-D-glucopyranosid (4:1), B-Methyl D-glucopyranoside, propoxylated, 2-(2-hydroxypropoxy)propan-1-ol-methyl beta-D-glucopyranoside (4:1), Glucam P-10/20, MeG P-20, PPG-20 Methyl Glucose Ether, Methyl Glucose Ether, AEC PPG-20 METHYL GLUCOSE ETHER, GLUCAM P-20 HUMECTANT, MACBIOBRIDE MG-20P, METHYL GLUCOSIDE PROPOXYLATE (20), POLY(OXY(METHYL-1,2-ETHANEDIYL(20))), .ALPHA.-HYDRO-.OMEGA.-HYDROXY -, ETHER WITH METHYL .BETA.-D-GLUCOPYRANOSIDE (4:1), POLYOXYPROPYLENE (20) METHYL GLUCOSE ETHER, POLYPROPYLENE GLYCOL (20) METHYL GLUCOSE ETHER, PPG-20 METHYL GLUCOSE ETHER, PPG-20 METHYL GLUCOSE ETHER [INCI], GlucamP20, Unicam P20, Propoxylated Alcohol, PPG-20 Methyl Glucose Ether, Methyl glucoside propoxylate, B-Methyl D-glucopyranoside, propoxylated GLUCAM P-10/20, Glucam P-20 humectant, PPG-20 METHYL GLUCOSE ETHER, Methyl glucoside propoxylate, ylbeta-d-glucopyranoside(4:1), PPG-20 Methyl glucoside propoxylate, B-Methyl D-glucopyranoside, propoxylated, Polypropylene glycol beta-methyl glucoside ether (4:1), PPG-20 methyl glucose ether ( P-20 from Amerchol of Dow), Polypropylene glycol methyl beta-glucopyranoside ether (4:1), GLUCAM P-10/20, PPG-20 METHYL GLUCOSE ETHER, Polyoxy(methyl-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, ether with methyl .beta.-D-glucopyranoside (4:1), Poly(oxy(methyl-1,2-ethandiyl)), alpha-hydro-omega-hydroxy-, Ether mit Methyl-beta-D-glucopyranosid (4:1), B-Methyl D-glucopyranoside, propoxylated, Poly[oxy(methyl-1,2-ethanediyl)], α-hydro-ω-hydroxy-, ether with methyl -D-glucopyranoside (4:1), Methyl glucoside propoxylate, Polypropylene glycol beta-methyl glucoside ether (4:1),



Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether)is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.


In any product, Glucam P-20 (PPG-20 Methyl Glucose Ether) delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol has on skin.
Equally important in fragrance containing formulations, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a fixative by subduing volatilization of the "high notes".


The light color and low odor of Glucam P-20 (PPG-20 Methyl Glucose Ether) will not interfere with the mood the fragrance is trying to communicate.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is recommended for use in hair care and skin care products.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.


Glucam P-20 (PPG-20 Methyl Glucose Ether) offers lubricious, luxurious and emollient feel and depresses freezing point.
In alcohol-based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect on the skin.
Glucam P-20 (PPG-20 Methyl Glucose Ether) provides fragrance fixation by subduing volatilization of high notes.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.


In any product, Glucam P-20 (PPG-20 Methyl Glucose Ether) delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol has on skin.
Equally important in fragrance containing formulations, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a fixative by subduing volatilization of the "high notes".


The light color and low odor of Glucam P-20 (PPG-20 Methyl Glucose Ether) will not interfere with the mood the fragrance is trying to communicate.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally derived humectant, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is one of the few naturally derived cosmetic liquids that can be miscible with water, alcohols, organic esters and oils.


Glucam P-20 (PPG-20 Methyl Glucose Ether) provides moisture with a slippery, softening feel in any product. In alcohol-based systems,
Glucam P-20 (PPG-20 Methyl Glucose Ether) helps reduce the burning effect of alcohol on the skin.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is recommended to be used in hair care and skin care products.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is a humectant and emollient added to many personal care products.
Derived from glucose and plant-based oils, Glucam P-20 (PPG-20 Methyl Glucose Ether) is a clear, and colorless liquid that is largely soluble in water.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is known for its ability to improve the texture of skincare and haircare products, making them smoother and more spreadable.


Glucam P-20 (PPG-20 Methyl Glucose Ether) also helps to moisturize the surface that it is applied on and lock in hydration, leaving the surface feeling soft and supple.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a very useful ingredient that is commonly used in personal care products.


Equally important in fragrance containing formulations, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a fixative by subduing volatilization of the "high notes".
The light color and low odor of Glucam P-20 (PPG-20 Methyl Glucose Ether) will not interfere with the mood the fragrance is trying to communicate.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is a mild, non-irritative moisturizer derived from natural GLUCO.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is also a naturally-derived humectant, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.


In any product, Glucam P-20 (PPG-20 Methyl Glucose Ether) delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol has on skin.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived 100% active, propoxylated methyl glucose ether.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is one of the few naturally-derived cosmetic fluids that is miscible with water, alcohols, organic esters, and oils.


Glucam P-20 (PPG-20 Methyl Glucose Ether) delivers humectancy with a lubricious, emollient feel in any product.
Glucam P-20 (PPG-20 Methyl Glucose Ether) provides cleansing agent formula.
Mild naturally derived humectant, Alkoxylated methyl glycosides, such as Glucam P-20 (PPG-20 Methyl Glucose Ether), a solvent offering good fragrance fixation properties as well as interesting sensorial benefits such as the reduction in tackiness.


Glucam P-20 (PPG-20 Methyl Glucose Ether) provides excellent performances in AP/DEO formulations containing antiperspirant agents (e.g., aluminum chlorohydrate and aluminum zirconium chlorohydrate derivatives) by reducing white residue left on the skin and subsequently transferred onto textile substrates.


The formulation containing Glucam P-20 (PPG-20 Methyl Glucose Ether) also shows enhanced stability compared to the one without this humectant.
The formulation without Glucam P-20 (PPG-20 Methyl Glucose Ether) showed oil separation after 2 weeks at room temperature while the formulation with this humectant remained.


Alkoxylated methyl ether glycosides such as Glucam P-20 (PPG-20 Methyl Glucose Ether) can be formulated into antiperspirant and deodorant compositions to mitigate white stain transfer onto skin and textile substrates while providing some humectant and a good sensory profile.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived 100% active, propoxylated methyl glucose ether.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is a light yellow liquid with mild characteristic odor.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a hygroscopic propylated methyl glucose ether of natural origin with dissolving properties.
Glucam P-20 (PPG-20 Methyl Glucose Ether) has light color and indinstict odor .


Glucam P-20 (PPG-20 Methyl Glucose Ether) is used as an emollient or lubricant.
Glucam P-20 (PPG-20 Methyl Glucose Ether) also acts as a perfume stabilizer, by decreasing its volatility.
When added to products containing ethyl alcohol, Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging sensation it causes.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is an emollient.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is of natural origin.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is easily miscible with water, alcohols, organic esters and oils.


When used in cosmetic products Glucam P-20 (PPG-20 Methyl Glucose Ether) provides moisture and has a very good emollient effect.
When added to cosmetics containing alcohol, Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the irritation that alcohol can cause.



USES and APPLICATIONS of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
Glucam P-20 (PPG-20 Methyl Glucose Ether) has moisturizing and emollient properties that are beneficial for hair and skin formulations.
In hair care products, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a humectant, helping to retain moisture and prevent dryness.
Glucam P-20 (PPG-20 Methyl Glucose Ether) helps keep hair feeling soft, smooth, and hydrated.


Glucam P-20 (PPG-20 Methyl Glucose Ether) also aids in moisturizing and soothing the skin, leaving it feeling nourished.
Glucam P-20 (PPG-20 Methyl Glucose Ether) has a smoothing effect on the skin, which makes it a popular ingredient in anti-aging formulations.
Glucam P-20 (PPG-20 Methyl Glucose Ether) can be found in shampoos, conditioners, lotions, and creams, and is often used in combination with other ingredients to enhance its benefits.


Cosmetic Uses of Glucam P-20 (PPG-20 Methyl Glucose Ether): hair conditioning and skin conditioning.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is used Facial Cleansers (Bath and Shower), Hand Soap (Bath & Shower),
Shaving Products (Bath and Shower), Conditioner (Hair Care), Shampoo (Hair Care), Styling Products (Hair Care), After Shave (Skin Care), and Facial Care Products (Skin Care).


Glucam P-20 (PPG-20 Methyl Glucose Ether) is recommended for use in hair care and skin care products.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is used in shaving, styling, hair- & skin care products.
Use: In alcohol based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol has on skin.


Equally important in fragrance containing formulations, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a fixative by subduing volatilization of the "high notes".
The light color and low odor of Glucam P-20 (PPG-20 Methyl Glucose Ether) will not interfere with the mood the fragrance is trying to communicate.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is recommended for use in hair care and skin care products.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.


In any product, Glucam P-20 (PPG-20 Methyl Glucose Ether) delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol has on skin.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is designed for skin care formulations to deliver safe, effective moisturization without a heavy, greasy feel.


Because Glucam P-20 (PPG-20 Methyl Glucose Ether) is mild, vegetable-derived and non-comedogenic, it is especially well suited for products used around the eye or in formulations made for sensitive skin.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is one of the few naturally-derived cosmetic fluids that are miscible with water, alcohols, organic esters, and oils.


In any product, Glucam P-20 (PPG-20 Methyl Glucose Ether) delivers humectancy with a lubricious, emollient feel.
In alcohol-based systems Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol has on skin.
Equally important in fragrance containing formulations, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a fixative by subduing volatilization of the "high notes".


The light color and low odor of Glucam P-20 (PPG-20 Methyl Glucose Ether) will not interfere with the mood the fragrance is trying to communicate.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is recommended for use in hair care and skin care products.
In alcohol-based systems, Glucam P-20 (PPG-20 Methyl Glucose Ether) reduces the stinging effect alcohol can have on the skin.


Furthermore, Glucam P-20 (PPG-20 Methyl Glucose Ether) acts as a fixative in fragrance-containing formulations by reducing the volatilization of high notes.
The light color and low odor of Glucam P-20 (PPG-20 Methyl Glucose Ether) do not interfere with the mood the fragrance is trying to convey.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is recommended for use in hair and skin care products.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is designed for skin care formulations to deliver safe, effective moisturization without a heavy, greasy feel.
Because Glucam P-20 (PPG-20 Methyl Glucose Ether) is mild, vegetable-derived and non-comedogenic, it is especially well suited for products used around the eye or in formulations made for sensitive skin.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is suitable for use in dermocosmetics and hair products.
Glucam P-20 (PPG-20 Methyl Glucose Ether) stabilizes the fragrance by controlling the rapid evaporation of the perfume's high notes.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is ideal for making perfume or in cosmetics that want a long-lasting fragrance, such as body creams, insect repellents, deodorants, after shave, etc.


Glucam P-20 (PPG-20 Methyl Glucose Ether) is designed for skin care formulations to deliver safe, effective moisturization without a heavy, greasy feel.
Because Glucam P-20 (PPG-20 Methyl Glucose Ether) is mild, vegetable-derived and non-comedogenic, it is especially well suited for products used around the eye or in formulations made for sensitive skin.


-Fragrance Fixative uses of Glucam P-20 (PPG-20 Methyl Glucose Ether):
Glucam P-20 (PPG-20 Methyl Glucose Ether) is a naturally-derived, 100% active, propoxylated methyl glucose ether.
Glucam P-20 (PPG-20 Methyl Glucose Ether) offers lubricious, luxurious emollient feel, reduces stinging effect and depresses freezing point.
Glucam P-20 (PPG-20 Methyl Glucose Ether) provides fragrance fixation by subduing volatilization of high notes.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is used in hand soaps, shampoos, shaving & styling preparations and facial care products.



FUNCTIONS OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
*Emollient,
*Fixative,
*Humectant



KEY FEATURES AND BENEFITS OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
*Glucam P-20 (PPG-20 Methyl Glucose Ether) is derived from natural sources
*Humectant
*Stability enhancement
*Reduction of antiperspirant white stain transfer marks
*Good spreading and sensory profile
*Mildness
*Fragrance fixation
*Glucam P-20 (PPG-20 Methyl Glucose Ether) effectively reduces odor, and also show excellent sensorial properties and reduce white stains and marks on both clothes and skin.



BENEFITS OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
*freezing point lowering
*luxury feeling
*Miscible with water, alcohols, organic esters and oils
*naturally derived
*Helps reduce alcohol burn



FUNCTIONS OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
Is an extremely effective emollient, fragrance fixative and humectant for hair care and skin care products.



ALTERNATIVES OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
*GLYCERIN,
*SODIUM PCA,
*CAPRYLYL GLYCOL



WHAT DOES GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER) DO IN A FORMULATION?
*Emollient
*Hair conditioning
*Humectant
*Skin conditioning



ORIGIN OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
Glucam P-20 (PPG-20 Methyl Glucose Ether) is made by combining plant-based oils and glucose.
The process involves the reaction of the oils with glucose to form a complex mixture of esters.
This mixture is then further processed to produce the final ingredient.



SAFETY PROFILE OF GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
Glucam P-20 (PPG-20 Methyl Glucose Ether) is generally considered a safe ingredient for use in a variety of different products within the cosmetic industry.
Glucam P-20 (PPG-20 Methyl Glucose Ether) is well tolerated by most skin and hair types and is also non-comedogenic.
Patch testing is not typically necessary for this ingredient.

Additionally, Glucam P-20 (PPG-20 Methyl Glucose Ether) is vegan and halal, making it a suitable ingredient for those following a vegan or halal lifestyle.
As with any cosmetic ingredient, it is important to use products containing Glucam P-20 (PPG-20 Methyl Glucose Ether) as directed and discontinue use if any signs of irritation or allergic reaction occur.



PHYSICAL and CHEMICAL PROPERTIES of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
Physical state: no data available
Colour: no data available
Odour: no data available
Melting point/ freezing point: no data available
Boiling point or initial boiling point and boiling range: 389.1\u00baC at 760 mmHg
Flammability: no data available
Lower and upper explosion limit / flammability limit: no data available
Flash point: 189.1\u00baC
Auto-ignition temperature: no data available
Decomposition temperature: no data available
pH: no data available
Kinematic viscosity: no data available
Solubility: no data available
Partition coefficient n-octanol/water (log value): no data available

Vapour pressure: no data available
Density and/or relative density: no data available
Relative vapour density: no data available
Particle characteristics: no data available
Molecular Weight: 730.9
Hydrogen Bond Donor Count: 12
Hydrogen Bond Acceptor Count: 18
Rotatable Bond Count: 18
Exact Mass: 730.45621538
Monoisotopic Mass: 730.45621538
Topological Polar Surface Area: 298 Ų
Heavy Atom Count: 49

Formal Charge: 0
Complexity: 228
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 5
Undefined Atom Stereocenter Count: 8
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 5
Compound Is Canonicalized: Yes
Appearance: Pale yellow viscous syrup
Assay: Min. 99.0%
Odor: Mild
Acid number, mg/g: Max. 11
Hydroxyl value, mg/g: 270-305
Moisture, % WT.: Max. 1.0
Saponification value, mg/g: 125-140

Iodine value: 1
Ash, % WT.: Max. 0.5
Color, Gardner: Max. 7
Melt range, °C: 48-55
Appearance: Pale yellow viscous syrup
Assay: Min. 99.0%
Odor: Mild
Acid number, mg/g: Max. 11
Hydroxyl value, mg/g: 270-305
Moisture, % WT.: Max. 1.0
Saponification value, mg/g: 125-140
Iodine value: 1
Ash, % WT.: Max. 0.5
Color, Gardner: Max. 7
Melt range, ℃: 48-55
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 389.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)

Flash Point: 372.00 °F. TCC ( 189.10 °C. ) (est)
logP (o/w): -2.690 (est)
CAS No.: 61849-72-7
Molecular Formula: C31H70O18
Formula Weight: 730.8767
Assay: 98%
Molecular Formula: C31H70O18
Molar Mass: 730.8767
Boling Point: 389.1°C at 760 mmHg
Flash Point: 189.1°C
Vapor Presure: 1.15E-07mmHg at 25°C
Appearance: colorless to light yellow clear liquid
Acidity: ≤1
Saponification value: ≤1
Hydroxyl value: 160-180

Iodine value: ≤1
Moisture: ≤1
Assay: 95.00 to 100.00 %
Food Chemicals Codex Listed: No
Boiling Point: 389.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 372.00 °F. TCC ( 189.10 °C. ) (est)
logP (o/w): -2.690 (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 389.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 372.00 °F. TCC ( 189.10 °C. ) (est)
logP (o/w): -2.690 (est)
Boiling Point: 250-270°C
Melting Point: 25-30°C
pH: 6.0-7.0
Solubility: Highly soluble in water
Viscosity: Low



FIRST AID MEASURES of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
-Description of necessary first-aid measures:
*General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.
-Most important symptoms/effects, acute and delayed:
no data available
-Indication of immediate medical attention and special treatment needed, if necessary:
no data available



ACCIDENTAL RELEASE MEASURES of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
-Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
-Methods and materials for containment and cleaning up:
Pick up and arrange disposal.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Specific hazards arising from the chemical:
no data available
-Special protective actions for fire-fighters:
Wear self-contained breathing apparatus for firefighting if necessary.



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
-Control parameters:
*Occupational Exposure limit values:
no data available
*Biological limit values:
no data available
-Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Individual protection measures, such as personal protective equipment (PPE):
*Eye/face protection:
Safety glasses with side-shields.
Use equipment for eye protection.
*Skin protection:
Wear impervious clothing.
Handle with gloves.
Wash and dry hands.
-Thermal hazards:
no data available



HANDLING and STORAGE of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of GLUCAM P-20 (PPG-20 METHYL GLUCOSE ETHER):
-Reactivity:
no data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
no data available
-Conditions to avoid:
no data available
-Incompatible materials:
no data available
-Hazardous decomposition products:
no data available



GLUCAMATE DOE-120
Glucamate DOE-120 is a nonionic surfactant and emulsifier derived from naturally occurring raw materials, specifically dicarboxylic acids and alcohols.
Glucamate DOE-120 is methyl glucose ether esterified with oleic acid.
Glucamate DOE-120 provides formulations with foaming properties that are easy to pour and aesthetically pleasing.

CAS NUMBER: 86893-19-8
Molecular Formula: (C2H4O)mult(C2H4O)multC43H78O

Glucamate DOE-120 is a naturally derived methyl glucose ether esterified with oleic acid.
Importantly, adding a Glucamate DOE-120 Syrup thickener to formulas can significantly reduce eye irritation.
Glucamate DOE-120 is a naturally derived grade.

Glucamate DOE-120 is mild, non-irritating to the eyes and feels light.
Glucamate DOE-120 is used in shampoos, body lotions, liquid soaps, baby shampoos, special and mild cleaners.
Glucamate DOE-120 is a 70% active, naturally derived methyl glucose ether esterified with oleic acid.

Glucamate DOE-120 exhibits aesthetically pleasing foaming properties, creates very smooth formulations, high viscosity, smoothness and does not cause eye irritation.
The multifunctionality of Glucamate DOE-120 to viscous and reduce irritation makes it ideal for use in cleaning.

Glucamate DOE-120 thickener by Lubrizol is a naturally derived grade.
It is methyl glucose ether which has been esterified with oleic acid.
Glucamate DOE-120 is mild, non-irritating to the eyes and offers light feel.

Glucamate DOE-120 enables formulations that are easy to pour and have aesthetically pleasing foaming properties.
Glucamate DOE-120 thickener is used in shampoos, body washes, liquid soaps, baby shampoos, intimate & mild cleansers.
Glucamate DOE-120 is a naturally derived Methyl Glucoside derivative.

Glucamate DOE-120 adds body and provides a rich skin feel to this extremely light, high foaming body shampoo.
Glucamat DOE-120 derivatives are well known for their mildness and irritation-relieving properties.
Glucamate DOE-120 is a natural glucose derivative from corn and acts as a high-efficiency thickener in shampoo, body wash, facial care.

Glucamate DOE-120 can be applied to some surfactants, especially those that are difficult to thicken.
Glucamate DOE-120 is non-irritating to the eyes, while significantly reducing the irritation of the entire formula.
Glucamate DOE-120 is a highly effective nonionic thickener for hair a highly effective nonionic thickener for hair care

Glucamate DOE-120 is a care and skin care product.
Glucamate DOE-120 is derived from the thickener Glucamate DOE-120, which is derived from corn.
Due to its easy-to-use flaky form, Glucamate DOE-120 is easily formulated.

Glucamate DOE-120 is a vegetable-derived, high-efficiency viscosity builder designed for use with many anionic compounds.
Glucamate DOE-120 is a natural GLUCO™se derivative from corn, acting as high-efficient thickener in shampoo, body wash, facial cleanser and baby cleanser.
It is especially applicable to some surfactants hardly to thicken.

Glucamate DOE-120 causes no irritation to eyes, meanwhile significantly reduces irritation of whole formula.
Glucamate DOE-120 is effective at forming and stabilizing oil-in-water emulsions.
This makes it valuable in cosmetic formulations where ingredients with different solubilities need to be combined.

Glucamate DOE-120 exhibits good compatibility with a wide range of cosmetic ingredients, including oils, waxes, and other surfactants.
This versatility allows formulators to use it in various cosmetic products.

Glucamate DOE-120 can improve the sensory characteristics of formulations, providing a smooth and luxurious feel to the final product.
In addition to its emulsifying properties, Glucamate DOE-120 can also act as a thickening agent, contributing to the overall consistency of the product.
Glucamate DOE-120 is derived from naturally occurring raw materials, which may appeal to consumers looking for more natural or sustainable cosmetic products.

Color: Pale Yellow
Flash Point: 368ºC
Phase: Waxy solid
Boiling Point F(C): 212.0° (100.0°)
Chemical Stability: Stable under normal ambient temperature and conditions

Glucamate DOE-120 is a product of Lubrizol Corporation, a specialty chemical company.
It is a multifunctional ingredient used primarily in the personal care and cosmetic industry.
More specifically, Glucamate DOE-120 is a nonionic surfactant and emulsifier derived from naturally occurring raw materials, specifically dicarboxylic acids and alcohols.

In cosmetic formulations, Glucamate DOE-120 serves as an emulsifier, helping to stabilize oil-in-water emulsions and improving the texture and feel of the final product.
It is commonly used in creams, lotions, sunscreens, and other personal care products where the mixing of water and oil-based ingredients is necessary.

Glucamate DOE-120 with zero eye irritation test scores, the thickener is non-irritating to the eyes, making it ideal for baby shampoos.
Glucamate DOE-120 adding this thickener to formulas can significantly reduce eye irritation normally associated with harsh ingredients.

Glucamate DOE-120 is generally considered safe and widely used in the cosmetic industry, it is crucial to follow the manufacturer's guidelines and conduct proper testing when formulating cosmetic products.
Additionally, regulations and safety assessments may vary from country to country, so compliance with local regulations is essential.
Glucamate DOE-120 is recommended for clean beauty applications.

Glucamate DOE-120 thickener is a naturally-derived, methyl glucose ether which has been esterified with oleic acid.
It is a flaked solid, highly efficient viscosity builder designed for use with numerous anionic surfactants and amphoteric surfactant systems popular in many shampoos, body washes, and liquid soaps.
Glucamate DOE-120 thickener is non-irritating to the eyes, making it ideal for baby shampoos.

Uses
Glucamate DOE-120 is used to create stable oil-in-water emulsions in various cosmetic products such as creams, lotions, and moisturizers.
It allows the incorporation of both water-soluble and oil-soluble ingredients, providing a well-blended and consistent product.

Glucamate DOE-120 is often utilized in sunscreen formulations to help disperse UV filters evenly throughout the product, enhancing their effectiveness and ensuring uniform coverage on the skin.

Glucamate DOE-120 can be found in hair conditioners and styling products.
It aids in emulsifying and delivering beneficial oils and conditioning agents to the hair strands, promoting manageability and softness.
In liquid cleansers and body washes, Glucamate DOE-120 functions as an emulsifier, ensuring the proper mixing of water and oil components while providing a pleasant, smooth texture.

Glucamate DOE-120 is used in various makeup products like foundations, BB creams, and tinted moisturizers to create stable formulations and improve the spreadability and blending of pigments.
Glucamate DOE-120 is utilized in sunless tanning products to help disperse and stabilize the active tanning ingredient, resulting in a more even and natural-looking tan.

Glucamate DOE-120s thickening properties make it suitable for increasing the viscosity of creams and lotions, giving them a rich, luxurious feel.
Due to its mildness and compatibility with other ingredients, Glucamate DOE-120 can be found in baby lotions, creams, and gentle skincare products.
Glucamate DOE-120 can be found in shampoos, where it acts as an emulsifier to combine water and oil-based ingredients, improving the stability of the formulation and enhancing the conditioning properties.

In hair styling products like gels and mousses, Glucamate DOE-120 contributes to the product's texture, spreadability, and ease of application, making it easier to achieve desired hairstyles.
It is commonly used in body lotions and moisturizers to create smooth and non-greasy formulations that are easily absorbed by the skin.
Glucamate DOE-120 can be found in various anti-aging creams and serums due to its ability to stabilize active ingredients like retinoids and antioxidants.

In facial cleansers, Glucamate DOE-120 helps to emulsify oil and dirt, making it easier to wash away impurities and leave the skin feeling clean and refreshed.
Apart from sunscreens, Glucamate DOE-120 can also be used in after-sun products to enhance the absorption of moisturizing and soothing ingredients.
It can be employed in massage oils to improve the dispersion of oils and other beneficial ingredients, providing a smooth and enjoyable massage experience.

In roll-on and stick deodorants, Glucamate DOE-120 assists in forming a stable and smooth emulsion of active odor-controlling ingredients.
Due to its excellent compatibility with various actives, it is used in facial serums to deliver targeted skin treatments effectively.
Glucamate DOE-120 may be used in bath oils, shower gels, and body washes to create emulsified formulas that leave the skin feeling moisturized.

Skin Irritation
In its concentrated form, Glucamate DOE-120 may cause skin irritation or sensitization in some individuals.
Proper handling and protective equipment, such as gloves, should be used when working with the undiluted product.

Eye Irritation
Contact with the eyes should be avoided, as Glucamate DOE-120 may cause eye irritation.
In case of accidental eye contact, rinse the eyes thoroughly with water and seek medical attention if irritation persists.

Inhalation
While Glucamate DOE-120 is not known to be volatile, inhalation of dust or aerosols during handling could cause irritation to the respiratory tract.
Glucamate DOE-120 is advisable to work in a well-ventilated area and use appropriate respiratory protection if necessary.

Ingestion
Glucamate DOE-120 is not intended for ingestion. Swallowing the product may lead to gastrointestinal irritation.
As with any chemical, Glucamate DOE-120 is essential to follow proper waste disposal procedures and local regulations to minimize any potential environmental impact.

Synonyms
PEG-120 methyl glucose dioleate
AEC PEG-120 METHYL GLUCOSE DIOLEATE
ANTIL 120 PLUS
GLUCAMATE DOE-120 THICKENER
MACROGOL 120 METHYL GLUCOSE DIOLEATE
PEG 120 methyl glucose dioleate
PEG-120 METHYL GLUCOSE DIOLEATE (II)
POLYETHYLENE GLYCOL (120) METHYL GLUCOSE DIOLEATE
YM0K64F20V

GLUCO DEO120
Gluco Deo120 is a natural glucose derivative from corn, acting as high-efficient thickener in shampoo, body wash, facial cleanser and baby cleanser.
Gluco Deo120 imparts a soft and gentle after feel.
Gluco Deo120 is especially applicable in shampoo, body wash and facial cleanser.

CAS: 86893-19-8
MF: (C2H4O)mult(C2H4O)multC43H78O

Synonyms
PEG 120 METHYL GLUCOSE DIOLEATE;2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-,etherwithmethylD-glucopyranoside2,6-di-9-octadecePoly(oxy-1;2-ethanediyl),alpha-hydro-omega-hydroxy-poly(oxy-etherwithmethyld-glu;6-di-9-octadecenoate(2:1),(z,z)-copyranoside;alpha-hydro-omega-hydroxy-,etherwithmethyld-glucopyranoside2,6-di-9-octadecenoapoly(oxy-2-ethanediyl);Antil 120 Plus;Glucamate DOE-120 Thickener;glucamatedioleate;Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with methyl D-glucopyranoside 2,6-di-9-octadecenoate (2:1), (Z,Z)-;Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with methyl D-glucopyranoside 2,6-di-(9Z)-9-octadecenoate (2:1);Diethoxylated methyl glucopyranoside 2,6-dioleate;

Gluco Deo120 is the polyethylene glycol ether of the diester of natural Methylglucose and Oleic Acid.
Gluco Deo120 is used in cosmetics as a surfactant, thickener, and emulsifier.
Gluco Deo120 can reduce the irritation value of the entire formulation.
Gluco Deo120's high molecular weight makes it impenetrable to healthy skin.
Gluco Deo120 is available as a flaky solid or a liquid.
Gluco Deo120 is a non-ionic thickener, a naturally derived glucoside product.
Gluco Deo120 has good compatibility, does not reduce the foam of surfactant system, has good compounding and thickening effect with AOS, AES sodium salt, sulfosuccinate salt and amphoteric surfactant, no jelly feeling, excellent Synergy.

Gluco Deo120 has zero eye irritation test results, proving that it is completely non-irritating to the eyes, making it an ideal ingredient for baby shampoos.
In addition, the addition of Gluco Deo120 thickener to the formulation significantly reduces eye irritation caused by strong harsh surfactants.

Gluco Deo120 has multiple functions of increasing viscosity and reducing CI, and is often used in cleaning products.
Formulators can use Gluco Deo120 to formulate products that are easy to pour and provide foam aesthetics without the concern of altering foam characteristics.
Polyethylene glycol ether of the diester of methyl glucose and oleic acid with an average of 120 moles of ethylene oxide.
Surfactant/thickener/solubilizer/emulsifier mainly used in cosmetics and personal care products.
Very efficient, has a very good thickening effect on a variety of anionic surfactants and amphoteric surfactants.
Gluco Deo120 has no irritation to eyes and is very suitable for cleansing products and baby shampoos.
At the same time, Gluco Deo120 can significantly reduce the irritation of eyes by other surfactants.
Does not affect the foam characteristics of the surfactant.

BENEFITS:
Gentle and efficient natural origin.
Gluco Deo120 has broad compatibility with anionic surfactants and amphoteric surfactant systems.
Offers very soft sensory.
Gluco Deo120 does not irritate the eyes which makes it ideal in baby shampoos.
Creates gentle formulas reduces irritation to certain surfactants applied around the eyes.
Creates formulations that are easy to pour and maintains foam characteristics.
Gluco Deo120 can easily dissolve in the aqueous part of the surfactant-based formulation.

Features and Applications
Gluco Deo120 is a natural glucose derivative from corn, acting as high-efficient thickener in shampoo, body wash, facial cleanser and baby cleanser.
Gluco Deo120 is especially applicable to some surfactants hardly to thicken.
Gluco Deo120 causes no irritation to eyes, meanwhile significantly reduces irritation of whole formula.
Gluco Deo120 has superior ability to thicken many anionic and amphoteric surfactants.
GLUCONIC ACID
SYNONYMS D-Gluconic acid; Dextronic acid; Glosanto; 2,3,4,5,6-Pentahydroxyhexanoic acid; Gluconic acid; Glycogenic acid; Maltonic acid; Pentahydroxycaproic acid;CAS NO. 526-95-4
GLUCONIC ACID

DESCRIPTION:
Gluconic acid is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH.
Gluconic acid is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.

CAS Number: 526-95-4
EC Number: 208-401-4
IUPAC Name: (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
Molecular Formula: C6H12O7

In aqueous solution at neutral pH, gluconic acid forms the gluconate ion.
The salts of gluconic acid are known as "gluconates".
Gluconic acid, gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose.
Some drugs are injected in the form of gluconates.


Gluconic acid is a mild organic acid, neither caustic nor corrosive and with an excellent sequestering power.
Non-toxic and readily biodegradable (98 % after 2 days), it occurs naturally in plants, fruits and other foodstuffs such as wine (up to 0.25 %) and honey (up to 1 %).
Gluconic acid is prepared by fermentation of glucose, whereby the physiological d-form is produced.

In all recipes where gluconic acid is used together with sodium hydroxide, we recommend the direct use of sodium gluconate, the dry sodium salt of gluconic acid or the special product NAGLUSOL®.
Gluconic acid has versatile properties through being a polyhydroxycarboxylic acid, with both hydroxyl and carboxyl groups which can react.


Concentrated solutions of gluconic acid contain some lactone (GdL), the neutral cyclic ester, which is less soluble in the cold and possesses no actual acid properties.
About 5 % of GdL are present in the 50 % gluconic acid solution at room temperature.

The outstanding property of gluconic acid is its excellent chelating power, especially in alkaline and concentrated alkaline solutions.
In this respect, it surpasses all other chelating agents, such as EDTA, NTA and related compounds.
Calcium, iron, copper, aluminium and other heavy metals are firmly chelated in alkaline solution and masked in such a way that their interferences are eliminated.

Gluconic acid is stable at the boiling point even of concentrated alkaline solutions.
However, it is easily and totally degraded in waste water treatment plants (98 % after 2 days).


Gluconic acid is a gluconic acid having D-configuration.
Gluconic acid has a role as a chelator and a Penicillium metabolite.
Gluconic acid is a conjugate acid of a D-gluconate.

Gluconic acid is an enantiomer of a L-gluconic acid.
Commonly found in salts with sodium and calcium.

Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Gluconic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).

Gluconic Acid is an inorganic compound happens to be the 16 stereoisomers of 2,3,4,5,6-penta-hydroxyhexanoic acid.
Gluconic Acid is easily found in honey, plant, and wine.
Gluconic acid is produced by the oxidation of the first carbon of glucose with antiseptic and chelating properties.

Gluconic Acid 50% is composed of an equilibrium between the free acid and the two lactones.
This equilibrium is affected by the mixture's concentration and temperature.
A high concentration of the delta-lactone will favor the equilibrium to shift to the formation of gamma-lactone and vice versa.

A low temperature favors formation of glucono-delta-lactone while high temperatures will increase formation of glucono-gamma-lactone.
Under normal conditions, PMP Gluconic Acid 50% exhibits a stable equilibrium contributing to its clear to light yellow color with low level corrosiveness and toxicity.


Gluconic Acid is a mild tasting organic acid, neither caustic nor corrosive and with an excellent complexing ability.
Gluconic Acid occurs naturally in plants and foodstuffs, is non-toxic and is fully utilised in the body, like a carbohydrate.
Gluconic Acid is commercially produced by an aerobic oxidative fermentation of glucose, whereby the physiological d-form is produced.



CHEMICAL STRUCTURE OF GLUCONIC ACID:
The chemical structure of gluconic acid consists of a six-carbon chain, with five hydroxyl groups positioned in the same way as in the open-chained form of glucose, terminating in a carboxylic acid group.
In aqueous solution, gluconic acid exists in equilibrium with the cyclic ester glucono delta-lactone.

Gluconic Acid Structural Formula:
The gluconic acid structure features 6 carbon chain along with 5 hydroxyl groups placed in the general open-chain format of glucose, ending with the carboxylic acid group.
Gluconic acid exists in balance state in the aqueous state in the presence of cyclic ester glucono delta-lactone.



PRODUCTION OF GLUCONIC ACID:
Gluconic acid preparation was first reported by Hlasiwetz and Habermann in 1870 and involved the chemical oxidation of glucose.
In 1880, Boutroux prepared and isolated gluconic acid using the glucose fermentation.

Contemporary methods for the gluconic acid production utilize variations of glucose (or other carbohydrate-containing substrate) oxidation using fermentation or noble metal catalysis.



OCCURRENCE AND USES OF GLUCONIC ACID:
Gluconic acid occurs naturally in fruit, honey, and wine.
As a food additive (E574), Gluconic acid is now known as an acidity regulator.

The gluconate anion chelates Ca2+, Fe2+, K+, Al3+, and other metals, including lanthanides and actinides.
Gluconic acid is also used in cleaning products, where it dissolves mineral deposits, especially in alkaline solution.

Zinc gluconate injections are used to neuter male dogs.
Gluconate is also used in building and construction as a concrete admixture (retarder) to slow down the cement hydration reactions, and to delay the cement setting time.
Gluconic acid allows for a longer time to lay the concrete, or to spread the cement hydration heat over a longer period of time to avoid too high a temperature and the resulting cracking.

Retarders are mixed in to concrete when the weather temperature is high or to cast large and thick concrete slabs in successive and sufficiently well-mixed layers.
Gluconic acid aqueous solution finds application as a medium for organic synthesis.


Medicine:
In medicine, gluconate is used most commonly as a biologically neutral carrier of Zn2+, Ca2+, Cu2+, Fe2+, and K+ to treat electrolyte imbalance.
Calcium gluconate, in the form of a gel, is used to treat burns from hydrofluoric acid; calcium gluconate injections may be used for more severe cases to avoid necrosis of deep tissues, as well as to treat hypocalcemia in hospitalized patients.

Gluconate is also an electrolyte present in certain solutions, such as "plasmalyte a", used for intravenous fluid resuscitation.
Quinine gluconate is a salt of gluconic acid and quinine, which is used for intramuscular injection in the treatment of malaria.
Ferrous gluconate injections have been proposed in the past to treat anemia


Gluconic acid is used for industrial cleaning, textile bleach stabilizing, aluminium processing, and as a chelating agent in cement set retarding.
Gluconic acid is also used for metal surface treatment, cleaning products, personal care products, pharmaceuticals, and as a food additive.
Calcium gluconate is used in the treatment of patients with hypocalcemia, and its gel is used in the treatment of burns from hydrofluoric acid.

Quinine gluconate which is a salt of gluconic acid and quinine is used in the treatment of malaria.
Ferrous gluconate, or iron (II) gluconate, injections have been proposed in the past to treat anaemia, which occurs due to iron deficiency.
The gluconic acid aqueous solution is used as a medium for organic synthesis.


SPECIFICATIONS OF GLUCONIC ACID:
Gluconic acid technical grade is supplied as a 50 % aqueous solution in water.

Gluconic acid food grade is supplied in accordance with the latest requirements Commission Regulation (EU) No. 231/2012.
Gluconic acid food grade is offered as a 50 % aqueous solution.

Gluconic acid is available in liquid form as a 50 % aqueous solution.

Gluconic acid is supplied in bulk, in intermediate bulk containers (IBCs) with 1250 kg net weight (1000 kg net for the 50 % solution), and in drums with 250 kg net weight.
Other packaging types are available on request.


PROPERTIES OF GLUCONIC ACID:
Gluconic acid is Non-toxic
Gluconic acid is Easily biodegradable (98 % after 2 days)
Mild taste

Gluconic acid is Least corrosive organic acid
Gluconic acid is Main functions
Gluconic acid is Excellent chelating agent


APPLICATIONS OF GLUCONIC ACID :
Gluconic acid has versatile properties through being a polyhydroxycarboxylic acid, with both hydroxyl and carboxyl groups which can react.

Concentrated solutions of gluconic acid contain some lactone (GDL), the neutral cyclic ester, which is less soluble in the cold and possesses no actual acid properties.
About 5 % of GdL are present in the 50 % gluconic acid solution at room temperature.

The outstanding property of gluconic acid is its excellent chelating power, especially in alkaline and concentrated alkaline solutions.
In this respect, it surpasses all other chelating agents, such as EDTA, NTA and related compounds.
Calcium, iron, copper, aluminum and other heavy metals are firmly chelated in alkaline solution and masked in such a way that their interferences are eliminated.

Gluconic acid is stable at the boiling point even of concentrated alkaline solutions.
However, it is easily and totally degraded in waste water treatment plants (98% after 2 days)


CHEMICAL AND PHYSICAL PROPERTIES OF GLUCONATE:
Chemical formula C6H12O7
Molar mass 196.155 g•mol−1
Appearance Colorless crystals
Melting point 131 °C (268 °F; 404 K)
Solubility in water 316 g/L
Acidity (pKa) 3.86
Molecular Weight
196.16 g/mol
XLogP3-AA
-3.4
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
7
Rotatable Bond Count
5
Exact Mass
196.05830272 g/mol
Monoisotopic Mass
196.05830272 g/mol
Topological Polar Surface Area
138Ų
Heavy Atom Count
13
Formal Charge
0
Complexity
170
Isotope Atom Count
0
Defined Atom Stereocenter Count
4
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point 105 - 106 °C (1013 hPa)
Density 1.24 g/cm3 (20 °C)
pH value 2.2 (500 g/l, H₂O, 20 °C)
Assay (acidimetric) 48.0 - 52.0 %
Density (d 20 °C/ 4 °C) 1.229 - 1.245



SAFETY INFORMATION ABOUT GLUCONIC ACID:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



SYNONYMS OF GLUCONIC ACID:
boron gluconate
D-gluconate
D-gluconic acid
dextronic acid
gluconate
gluconic acid
gluconic acid, (113)indium-labeled
gluconic acid, (14)C-labeled
gluconic acid, (159)dysprosium-labeled salt
gluconic acid, (99)technecium (5+) salt
gluconic acid, 1-(14)C-labeled
gluconic acid, 6-(14)C-labeled
gluconic acid, aluminum (3:1) salt
gluconic acid, ammonium salt
gluconic acid, calcium salt
gluconic acid, cesium(+3) salt
gluconic acid, cobalt (2:1) salt
gluconic acid, copper salt
gluconic acid, Fe(+2) salt, dihydrate
gluconic acid, lanthanum(+3) salt
gluconic acid, magnesium (2:1) salt
gluconic acid, manganese (2:1) salt
gluconic acid, monolithium salt
gluconic acid, monopotassium salt
gluconic acid, monosodium salt
gluconic acid, potassium salt
gluconic acid, sodium salt
gluconic acid, strontium (2:1) salt
gluconic acid, tin(+2) salt
gluconic acid, zinc salt
lithium gluconate
magnerot
magnesium gluconate
maltonic acid
manganese gluconate
pentahydroxycaproic acid
sodium gluconate
zinc gluconate
gluconic acid
D-gluconic acid
526-95-4
dextronic acid
maltonic acid
Glycogenic acid
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
Glosanto
Pentahydroxycaproic acid
gluconate
Gluconic acid, D-
D-Gluco-hexonic acid
Glyconic acid
Gluconic acid (VAN)
133-42-6
HSDB 487
D-Gluconsaeure
D-Glukonsaeure
BRN 1726055
EINECS 208-401-4
UNII-R4R8J0Q44B
NSC 77381
R4R8J0Q44B
DTXSID8027169
CHEBI:33198
2,3,4,5,6-Pentahydroxyhexanoic acid
GLUCONAL GA-50
Hexonic acid
DTXCID307169
INS NO.574
DTXSID8042000
INS-574
EC 208-401-4
4-03-00-01255 (Beilstein Handbook Reference)
Dextronate
Glycogenate
Glyconate
Maltonate
NSC-77381
157663-13-3
C6H12O7
E-574
124423-64-9
GCO
GLUCONIC ACID (MART.)
GLUCONIC ACID [MART.]
AMMONIUM GLUCONATE
2,3,4,5,6-pentahydroxyhexanoate
19222-41-4
NSC77381
sodium-gluconate
C6-H12-O7
ketogluconic acid
D- Gluconic acid
D-?Gluconic acid
Pentahydroxycaproate
SCHEMBL971
bmse000084
GLUCONIC ACID [MI]
Pesticide Code: 000104
GLUCONIC ACID [HSDB]
GLUCONIC ACID [INCI]
GLUCONIC ACID [VANDF]
CHEMBL464345
D-Gluconic acid 50% in water
GLUCONIC ACID [WHO-DD]
CHEBI:24266
RGHNJXZEOKUKBD-SQOUGZDYSA-N
DTXCID201012074
GluconicAcid(containsGluconolactone)
HY-Y0569
2,3,4,5,6-pentahydroxy-hexanoate
Calcium Gluconate (D-gluconic acid)
Tox21_202745
MFCD00004240
s3595
2,3,4,5,6-Pentahydroxycaproic acid
AKOS015895892
DB13180
2,3,4,5,6-pentahydroxy-hexanoic acid
Gluconic Acid (contains Gluconolactone)
NCGC00260293-01
CAS-526-95-4
E574
LS-71436
CS-0015343
G0036
2,3,4,5,6-Pentahydroxycaproic acid solution
C00257
D70789
EN300-7392806
Q407569
W-109086
6E52B5FC-5676-4139-977A-4D643EDDB159



GLUCONIC ACID
DESCRIPTION:
Gluconic acid is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH.
Gluconic acid is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.

CAS Number: 526-95-4
EC Number: 208-401-4
IUPAC Name: (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
Molecular Formula: C6H12O7

In aqueous solution at neutral pH, gluconic acid forms the gluconate ion.
The salts of gluconic acid are known as "gluconates".
Gluconic acid, gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose.
Some drugs are injected in the form of gluconates.


Gluconic acid is a mild organic acid, neither caustic nor corrosive and with an excellent sequestering power.
Non-toxic and readily biodegradable (98 % after 2 days), it occurs naturally in plants, fruits and other foodstuffs such as wine (up to 0.25 %) and honey (up to 1 %).
Gluconic acid is prepared by fermentation of glucose, whereby the physiological d-form is produced.

In all recipes where gluconic acid is used together with sodium hydroxide, we recommend the direct use of sodium gluconate, the dry sodium salt of gluconic acid or the special product NAGLUSOL®.
Gluconic acid has versatile properties through being a polyhydroxycarboxylic acid, with both hydroxyl and carboxyl groups which can react.


Concentrated solutions of gluconic acid contain some lactone (GdL), the neutral cyclic ester, which is less soluble in the cold and possesses no actual acid properties.
About 5 % of GdL are present in the 50 % gluconic acid solution at room temperature.

The outstanding property of gluconic acid is its excellent chelating power, especially in alkaline and concentrated alkaline solutions.
In this respect, it surpasses all other chelating agents, such as EDTA, NTA and related compounds.
Calcium, iron, copper, aluminium and other heavy metals are firmly chelated in alkaline solution and masked in such a way that their interferences are eliminated.

Gluconic acid is stable at the boiling point even of concentrated alkaline solutions.
However, it is easily and totally degraded in waste water treatment plants (98 % after 2 days).


Gluconic acid is a gluconic acid having D-configuration.
Gluconic acid has a role as a chelator and a Penicillium metabolite.
Gluconic acid is a conjugate acid of a D-gluconate.

Gluconic acid is an enantiomer of a L-gluconic acid.
Commonly found in salts with sodium and calcium.

Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Gluconic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).

Gluconic Acid is an inorganic compound happens to be the 16 stereoisomers of 2,3,4,5,6-penta-hydroxyhexanoic acid.
Gluconic Acid is easily found in honey, plant, and wine.
Gluconic acid is produced by the oxidation of the first carbon of glucose with antiseptic and chelating properties.

Gluconic Acid 50% is composed of an equilibrium between the free acid and the two lactones.
This equilibrium is affected by the mixture's concentration and temperature.
A high concentration of the delta-lactone will favor the equilibrium to shift to the formation of gamma-lactone and vice versa.

A low temperature favors formation of glucono-delta-lactone while high temperatures will increase formation of glucono-gamma-lactone.
Under normal conditions, PMP Gluconic Acid 50% exhibits a stable equilibrium contributing to its clear to light yellow color with low level corrosiveness and toxicity.


Gluconic Acid is a mild tasting organic acid, neither caustic nor corrosive and with an excellent complexing ability.
Gluconic Acid occurs naturally in plants and foodstuffs, is non-toxic and is fully utilised in the body, like a carbohydrate.
Gluconic Acid is commercially produced by an aerobic oxidative fermentation of glucose, whereby the physiological d-form is produced.



CHEMICAL STRUCTURE OF GLUCONIC ACID:
The chemical structure of gluconic acid consists of a six-carbon chain, with five hydroxyl groups positioned in the same way as in the open-chained form of glucose, terminating in a carboxylic acid group.
In aqueous solution, gluconic acid exists in equilibrium with the cyclic ester glucono delta-lactone.

Gluconic Acid Structural Formula:
The gluconic acid structure features 6 carbon chain along with 5 hydroxyl groups placed in the general open-chain format of glucose, ending with the carboxylic acid group.
Gluconic acid exists in balance state in the aqueous state in the presence of cyclic ester glucono delta-lactone.



PRODUCTION OF GLUCONIC ACID:
Gluconic acid preparation was first reported by Hlasiwetz and Habermann in 1870 and involved the chemical oxidation of glucose.
In 1880, Boutroux prepared and isolated gluconic acid using the glucose fermentation.

Contemporary methods for the gluconic acid production utilize variations of glucose (or other carbohydrate-containing substrate) oxidation using fermentation or noble metal catalysis.



OCCURRENCE AND USES OF GLUCONIC ACID:
Gluconic acid occurs naturally in fruit, honey, and wine.
As a food additive (E574), Gluconic acid is now known as an acidity regulator.

The gluconate anion chelates Ca2+, Fe2+, K+, Al3+, and other metals, including lanthanides and actinides.
Gluconic acid is also used in cleaning products, where it dissolves mineral deposits, especially in alkaline solution.

Zinc gluconate injections are used to neuter male dogs.
Gluconate is also used in building and construction as a concrete admixture (retarder) to slow down the cement hydration reactions, and to delay the cement setting time.
Gluconic acid allows for a longer time to lay the concrete, or to spread the cement hydration heat over a longer period of time to avoid too high a temperature and the resulting cracking.

Retarders are mixed in to concrete when the weather temperature is high or to cast large and thick concrete slabs in successive and sufficiently well-mixed layers.
Gluconic acid aqueous solution finds application as a medium for organic synthesis.


Medicine:
In medicine, gluconate is used most commonly as a biologically neutral carrier of Zn2+, Ca2+, Cu2+, Fe2+, and K+ to treat electrolyte imbalance.
Calcium gluconate, in the form of a gel, is used to treat burns from hydrofluoric acid; calcium gluconate injections may be used for more severe cases to avoid necrosis of deep tissues, as well as to treat hypocalcemia in hospitalized patients.

Gluconate is also an electrolyte present in certain solutions, such as "plasmalyte a", used for intravenous fluid resuscitation.
Quinine gluconate is a salt of gluconic acid and quinine, which is used for intramuscular injection in the treatment of malaria.
Ferrous gluconate injections have been proposed in the past to treat anemia


Gluconic acid is used for industrial cleaning, textile bleach stabilizing, aluminium processing, and as a chelating agent in cement set retarding.
Gluconic acid is also used for metal surface treatment, cleaning products, personal care products, pharmaceuticals, and as a food additive.
Calcium gluconate is used in the treatment of patients with hypocalcemia, and its gel is used in the treatment of burns from hydrofluoric acid.

Quinine gluconate which is a salt of gluconic acid and quinine is used in the treatment of malaria.
Ferrous gluconate, or iron (II) gluconate, injections have been proposed in the past to treat anaemia, which occurs due to iron deficiency.
The gluconic acid aqueous solution is used as a medium for organic synthesis.


SPECIFICATIONS OF GLUCONIC ACID:
Gluconic acid technical grade is supplied as a 50 % aqueous solution in water.

Gluconic acid food grade is supplied in accordance with the latest requirements Commission Regulation (EU) No. 231/2012.
Gluconic acid food grade is offered as a 50 % aqueous solution.

Gluconic acid is available in liquid form as a 50 % aqueous solution.

Gluconic acid is supplied in bulk, in intermediate bulk containers (IBCs) with 1250 kg net weight (1000 kg net for the 50 % solution), and in drums with 250 kg net weight.
Other packaging types are available on request.


PROPERTIES OF GLUCONIC ACID:
Gluconic acid is Non-toxic
Gluconic acid is Easily biodegradable (98 % after 2 days)
Mild taste

Gluconic acid is Least corrosive organic acid
Gluconic acid is Main functions
Gluconic acid is Excellent chelating agent


APPLICATIONS OF GLUCONIC ACID :
Gluconic acid has versatile properties through being a polyhydroxycarboxylic acid, with both hydroxyl and carboxyl groups which can react.

Concentrated solutions of gluconic acid contain some lactone (GDL), the neutral cyclic ester, which is less soluble in the cold and possesses no actual acid properties.
About 5 % of GdL are present in the 50 % gluconic acid solution at room temperature.

The outstanding property of gluconic acid is its excellent chelating power, especially in alkaline and concentrated alkaline solutions.
In this respect, it surpasses all other chelating agents, such as EDTA, NTA and related compounds.
Calcium, iron, copper, aluminum and other heavy metals are firmly chelated in alkaline solution and masked in such a way that their interferences are eliminated.

Gluconic acid is stable at the boiling point even of concentrated alkaline solutions.
However, it is easily and totally degraded in waste water treatment plants (98% after 2 days)


CHEMICAL AND PHYSICAL PROPERTIES OF GLUCONATE:
Chemical formula C6H12O7
Molar mass 196.155 g•mol−1
Appearance Colorless crystals
Melting point 131 °C (268 °F; 404 K)
Solubility in water 316 g/L
Acidity (pKa) 3.86
Molecular Weight
196.16 g/mol
XLogP3-AA
-3.4
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
7
Rotatable Bond Count
5
Exact Mass
196.05830272 g/mol
Monoisotopic Mass
196.05830272 g/mol
Topological Polar Surface Area
138Ų
Heavy Atom Count
13
Formal Charge
0
Complexity
170
Isotope Atom Count
0
Defined Atom Stereocenter Count
4
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point 105 - 106 °C (1013 hPa)
Density 1.24 g/cm3 (20 °C)
pH value 2.2 (500 g/l, H₂O, 20 °C)
Assay (acidimetric) 48.0 - 52.0 %
Density (d 20 °C/ 4 °C) 1.229 - 1.245



SAFETY INFORMATION ABOUT GLUCONIC ACID:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



SYNONYMS OF GLUCONIC ACID:
boron gluconate
D-gluconate
D-gluconic acid
dextronic acid
gluconate
gluconic acid
gluconic acid, (113)indium-labeled
gluconic acid, (14)C-labeled
gluconic acid, (159)dysprosium-labeled salt
gluconic acid, (99)technecium (5+) salt
gluconic acid, 1-(14)C-labeled
gluconic acid, 6-(14)C-labeled
gluconic acid, aluminum (3:1) salt
gluconic acid, ammonium salt
gluconic acid, calcium salt
gluconic acid, cesium(+3) salt
gluconic acid, cobalt (2:1) salt
gluconic acid, copper salt
gluconic acid, Fe(+2) salt, dihydrate
gluconic acid, lanthanum(+3) salt
gluconic acid, magnesium (2:1) salt
gluconic acid, manganese (2:1) salt
gluconic acid, monolithium salt
gluconic acid, monopotassium salt
gluconic acid, monosodium salt
gluconic acid, potassium salt
gluconic acid, sodium salt
gluconic acid, strontium (2:1) salt
gluconic acid, tin(+2) salt
gluconic acid, zinc salt
lithium gluconate
magnerot
magnesium gluconate
maltonic acid
manganese gluconate
pentahydroxycaproic acid
sodium gluconate
zinc gluconate
gluconic acid
D-gluconic acid
526-95-4
dextronic acid
maltonic acid
Glycogenic acid
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
Glosanto
Pentahydroxycaproic acid
gluconate
Gluconic acid, D-
D-Gluco-hexonic acid
Glyconic acid
Gluconic acid (VAN)
133-42-6
HSDB 487
D-Gluconsaeure
D-Glukonsaeure
BRN 1726055
EINECS 208-401-4
UNII-R4R8J0Q44B
NSC 77381
R4R8J0Q44B
DTXSID8027169
CHEBI:33198
2,3,4,5,6-Pentahydroxyhexanoic acid
GLUCONAL GA-50
Hexonic acid
DTXCID307169
INS NO.574
DTXSID8042000
INS-574
EC 208-401-4
4-03-00-01255 (Beilstein Handbook Reference)
Dextronate
Glycogenate
Glyconate
Maltonate
NSC-77381
157663-13-3
C6H12O7
E-574
124423-64-9
GCO
GLUCONIC ACID (MART.)
GLUCONIC ACID [MART.]
AMMONIUM GLUCONATE
2,3,4,5,6-pentahydroxyhexanoate
19222-41-4
NSC77381
sodium-gluconate
C6-H12-O7
ketogluconic acid
D- Gluconic acid
D-?Gluconic acid
Pentahydroxycaproate
SCHEMBL971
bmse000084
GLUCONIC ACID [MI]
Pesticide Code: 000104
GLUCONIC ACID [HSDB]
GLUCONIC ACID [INCI]
GLUCONIC ACID [VANDF]
CHEMBL464345
D-Gluconic acid 50% in water
GLUCONIC ACID [WHO-DD]
CHEBI:24266
RGHNJXZEOKUKBD-SQOUGZDYSA-N
DTXCID201012074
GluconicAcid(containsGluconolactone)
HY-Y0569
2,3,4,5,6-pentahydroxy-hexanoate
Calcium Gluconate (D-gluconic acid)
Tox21_202745
MFCD00004240
s3595
2,3,4,5,6-Pentahydroxycaproic acid
AKOS015895892
DB13180
2,3,4,5,6-pentahydroxy-hexanoic acid
Gluconic Acid (contains Gluconolactone)
NCGC00260293-01
CAS-526-95-4
E574
LS-71436
CS-0015343
G0036
2,3,4,5,6-Pentahydroxycaproic acid solution
C00257
D70789
EN300-7392806
Q407569
W-109086
6E52B5FC-5676-4139-977A-4D643EDDB159



GLUCONIC ACID (DEXTRONIC ACID)
Gluconic Acid (Dextronic acid) is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.
Gluconic Acid (Dextronic acid) is a fruit acid approved as a food additive under the number E 574 in Europe.
Gluconic Acid (Dextronic acid) is produced from glucose by oxidation at C1 of the glucose molecule.


CAS Number: 526-95-4 (D)
133-42-6 (racemate)
EC Number: 208-401-4
MDL Number: MFCD00004240
Molecular Formula: C6H12O7



SYNONYMS:
gluconic acid, D-gluconic acid, 526-95-4, dextronic acid, maltonic acid, Glycogenic acid, (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid, Glosanto, Pentahydroxycaproic acid, gluconate, Gluconic acid (VAN), 133-42-6, HSDB 487, D-Gluconsaeure, D-Glukonsaeure, BRN 1726055, EINECS 208-401-4, UNII-R4R8J0Q44B, NSC 77381, R4R8J0Q44B, DTXSID8027169, CHEBI:33198, 2,3,4,5,6-Pentahydroxyhexanoic acid, GLUCONAL GA-50, Hexonic acid, DTXCID307169, INS NO.574, DTXSID8042000, INS-574, EC 208-401-4, 4-03-00-01255 (Beilstein Handbook Reference), Dextronate, Glycogenate, Glyconate, Maltonate, NSC-77381, 157663-13-3, E-574, 124423-64-9, GCO, GLUCONIC ACID (MART.), GLUCONIC ACID [MART.], AMMONIUM GLUCONATE, 2,3,4,5,6-pentahydroxyhexanoate, 19222-41-4, NSC77381, sodium-gluconate, ketogluconic acid, D-?Gluconic acid, Pentahydroxycaproate, SCHEMBL971, bmse000084, GLUCONIC ACID [MI], Pesticide Code: 000104, GLUCONIC ACID [HSDB], GLUCONIC ACID [INCI], GLUCONIC ACID [VANDF], CHEMBL464345, D-Gluconic acid 50% in water, GLUCONIC ACID [WHO-DD], CHEBI:24266, DTXCID201012074, D-Gluconic Acid (50% in Water), GluconicAcid(containsGluconolactone), HY-Y0569, 2,3,4,5,6-pentahydroxy-hexanoate, Tox21_202745, MFCD00004240, s3595, 2,3,4,5,6-Pentahydroxycaproic acid, AKOS015895892, DB13180, 2,3,4,5,6-pentahydroxy-hexanoic acid, GLUCONIC ACID (50% IN WATER), NCGC00260293-01, CAS-526-95-4, E574, CS-0015343, G0036, NS00008847, 2,3,4,5,6-Pentahydroxycaproic acid solution, C00257, D70789, EN300-7392806, Q407569, W-109086, 6E52B5FC-5676-4139-977A-4D643EDDB159, d-Gluconic acid, Systematic IUPAC name (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid, Dextronic acid, D-gluconic acid, Dextronic acid, Pentahydroxycaproic acid, 2,3,4,5,6-Pentahydroxy-hexanoate, 2,3,4,5,6-Pentahydroxy-hexanoic acid, 2,3,4,5,6-Pentahydroxyhexanoate, 2,3,4,5,6-Pentahydroxyhexanoic acid, Aldonate, Aldonic acid, D-Gluco-hexonate, D-Gluco-hexonic acid, D-Gluconate, D-Gluconic acid, D-Gluconsaeure, D-Glukonsaeure, Dextronate, Dextronic acid, GCO, Glosanto, Gluconate, Gluconic acid, Glycogenate, Glycogenic acid, Glyconate, Glyconic acid, Hexonate, Hexonic acid, Maltonate, Maltonic acid, Pentahydroxycaproate, Pentahydroxycaproic acid, (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid, D-Gluco-hexonic acid, D-Gluconsaeure, D-Glukonsaeure, Dextronic acid, Glycogenic acid, Hexonic acid, Maltonic acid, D-Gluconate, (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoate, D-Gluco-hexonate, Dextronate, Glycogenate, Hexonate, Maltonate, D-Gluconic acid, Gluconate, 2,3,4,5,6-Pentahydroxy-hexanoate, 2,3,4,5,6-Pentahydroxy-hexanoic acid, 2,3,4,5,6-Pentahydroxyhexanoate, 2,3,4,5,6-Pentahydroxyhexanoic acid, GCO, Glosanto, Glyconate, Glyconic acid, Pentahydroxycaproate, Pentahydroxycaproic acid, Boron gluconate, Gluconic acid (113)indium-labeled, Gluconic acid calcium salt, Gluconic acid cesium(+3) salt, Gluconic acid lanthanum(+3) salt, Gluconic acid sodium salt, Gluconic acid strontium (2:1) salt, Magnerot, Manganese gluconate, Sodium gluconate, Zinc gluconate, Gluconic acid (159)dysprosium-labeled salt, Gluconic acid aluminum (3:1) salt, Gluconic acid ammonium salt, Gluconic acid magnesium (2:1) salt, Gluconic acid (14)C-labeled, Gluconic acid 1-(14)C-labeled, Gluconic acid 6-(14)C-labeled, Gluconic acid cobalt (2:1) salt, Gluconic acid copper salt, Gluconic acid manganese (2:1) salt, Gluconic acid potassium salt, Gluconic acid tin(+2) salt, Gluconic acid zinc salt, Lithium gluconate, Magnesium gluconate, Gluconic acid (99)technecium (5+) salt, Gluconic acid fe(+2) salt dihydrate, Gluconic acid monolithium salt, Gluconic acid monopotassium salt, Gluconic acid monosodium salt, gluconic, (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid, Hexonic acid, Glyconic acid, D-Gluconic acid solution, GLUCONIC ACI, d-gluconicaci, 2,3,4,5,6-Pentahydroxyhexanoic acid, glosanto, NSC 77381, D-Gluconic acid, Gluconic acid,D-, Gluconic acid, Maltonic acid, Dextronic acid, Glyconic acid, Glycogenic acid, Pentahydroxycaproic acid, NSC 77381, Gluconal GA-50, Sour Oligo, 723724-74-1, 887830-55-9, 880385-91-1, D-Gluconic Acid Solution, Dextronic Acid, Gluconal GA-50, Gluconic Acid, Glycogenic Acid, Glyconic Acid, Maltonic Acid, Pentahydroxycaproic Acid, (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic Acid, D-Gluconic acid, (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid, Dextronic acid, D-Gluconic acid, Gluconic acid, D-, 2,3,4,5,6-Pentahydroxyhexanoic acid, Dextronic acid, Glycogenic acid, Glyconic acid, Maltonic acid, Pentahydroxycaproic acid, NSC 77381



Gluconic Acid (Dextronic acid) is freely soluble in water with the solubility 100g/100ml at 25°C.
Gluconic Acid (Dextronic acid) is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH.
Gluconic Acid (Dextronic acid) is slightly soluble in alcohol, insoluble in ether and most other organic solvents.


Gluconic Acid (Dextronic acid) is the carboxylic acid by the oxidation with antiseptic and chelating properties.
Gluconic Acid (Dextronic acid) is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH.
Gluconic Acid (Dextronic acid) is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.


Gluconic Acid (Dextronic acid) is a fruit acid approved as a food additive under the number E 574 in Europe.
Gluconic Acid (Dextronic acid) is produced from glucose by oxidation at C1 of the glucose molecule.
Today, Gluconic Acid (Dextronic acid) is almost exclusively produced biotechnologically using cultures of Aspergillus niger.


The salts of Gluconic Acid (Dextronic acid) are called gluconates.
Gluconic Acid (Dextronic acid) is soluble in water and hydrolyzes into gluconic acid spontaneously and homogeneously lowers the pH.
Gluconic Acid (Dextronic acid) occurs naturally in small amounts in honey and wine.


Various teas may also contain Gluconic Acid (Dextronic acid).
Gluconic Acid (Dextronic acid) or Pentahydroxyhexanoic acid with chemical formula C6H12O7 was discovered in 1870 by Hlasiwetz and Habermann.
Gluconic Acid (Dextronic acid) is the carboxylic acid formed by the oxidation of the first carbon atom of glucose in the presence of bromine water.


In a simple dehydrogenation process involving glucose oxidase, Gluconic Acid (Dextronic acid) is produced from glucose.
Gluconic Acid (Dextronic acid), present in large quantities in plants, honey, and wine, can be manufactured using a fungal fermentation process in a commercial setting.


Gluconic Acid (Dextronic acid) is an inorganic compound happens to be the 16 stereoisomers of 2,3,4,5,6-penta-hydroxyhexanoic acid.
Gluconic Acid (Dextronic acid) is easily found in honey, plant, and wine.
Gluconic Acid (Dextronic acid) is produced by the oxidation of the first carbon of glucose with antiseptic and chelating properties.


Gluconic Acid (Dextronic acid) is an organic compound that is also termed Dextronic acid and is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.
Its IUPAC name is Gluconic Acid (Dextronic acid), and it has a molecular formula of C6H12O7.


Gluconic Acid (Dextronic acid) is a non-toxic compound that can be found in honey, wine, fruits, etc.
Gluconic Acid (Dextronic acid) appears as a colourless to light yellow, clear, syrupy liquid and has a mild acid taste.
Gluconic Acid (Dextronic acid) is very soluble in water, slightly soluble in alcohol, and insoluble in ether and many other organic solvents.


Gluconic Acid (Dextronic acid) was first discovered by Hlasiwetz and Habermann in 1870, through the chemical oxidation of glucose.
In the presence of the cyclic ester glucono-delta-lactone, Gluconic Acid (Dextronic acid) exists in equilibrium in an aqueous solution.
The salts of Gluconic Acid (Dextronic acid) are called gluconates, where a gluconate ion is formed by gluconic acid in an aqueous solution at neutral pH.


Gluconic Acid (Dextronic acid), gluconate salts, and gluconate esters are abundant in nature as they can be produced by the oxidation of glucose.
In an alkaline solution, the gluconate anion chelates Ca2+, Fe2+, Al3+, and other metals, including lanthanides and actinides.
Gluconic Acid (Dextronic acid) is a soluble crystalline organic acid made by the oxidation of glucose (using specific molds).


Gluconic Acid (Dextronic acid) is used in paint strippers.
Gluconic Acid (Dextronic acid) is an opticallyactive hydroxycarboxylic acid,CH2(OH)(CHOH)4COOH.
Gluconic Acid (Dextronic acid) is the carboxylicacid corresponding to the aldosesugar glucose, and can be madeby the action of certain moulds.


Gluconic Acid (Dextronic acid) is a non flammable.
Gluconic Acid (Dextronic acid) belongs to the class of organic compounds known as sugar acids and derivatives.
Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group.


Gluconic Acid (Dextronic acid) comes as a white pale yellow solution, with acidity of 50% minimum.
Gluconic Acid (Dextronic acid) is used in formulations, as well as in the textile, paper and fertilizer industries.
Gluconic Acid (Dextronic acid) (also known as gluconate) is an organic compound occurring widely in nature arising from the glucose oxidation.


Gluconic Acid (Dextronic acid) is naturally found in fruit, honey and wine.
Gluconic Acid (Dextronic acid) is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH.
Gluconic Acid (Dextronic acid) is one of the 16 stereoisomers of 2,3,4,5,6-penta hydroxy hexanoic acid.


In aqueous solution at neutral pH, Gluconic Acid (Dextronic acid) forms the gluconate ion.
The salts of gluconic acid are known as "gluconates".
Gluconic Acid (Dextronic acid), gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose.


Some drugs are injected in the form of gluconates.
Gluconic Acid (Dextronic acid) is a clear yellow to brownish-yellow solution
Gluconic Acid (Dextronic acid) is a naturally-occurring, organic carboxylic acid.


In alkaline solution, Gluconic Acid (Dextronic acid) is a strong chelating agent towards heavy metal anions.
Gluconic Acid (Dextronic acid), also known as D-gluconic acid, D-gluconate or (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid (also named dextronic acid), is the C1-oxidized form of D-glucose where the aldehyde group has become oxidized to the corresponding carboxylic acid.


Gluconic Acid (Dextronic acid) belongs to the class of organic compounds known as sugar acids and derivatives.
Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group.
In aqueous solution, Gluconic Acid (Dextronic acid) exists in equilibrium with the cyclic ester glucono delta-lactone.


Gluconic Acid (Dextronic acid) occurs naturally in fruit, honey, kombucha tea and wine.
The salts of Gluconic Acid (Dextronic acid) are known as "gluconates".
Gluconic Acid (Dextronic acid), gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose.


Gluconic Acid (Dextronic acid) exists in all living species, ranging from bacteria to plants to humans.
The metabolism of gluconate is well characterized in prokaryotes where Gluconic Acid (Dextronic acid) is known to be degraded following phosphorylation by gluconokinase.


Glucokinase activity has also been detected in mammals, including humans.
Gluconic Acid (Dextronic acid) is produced in the gluconate shunt pathway.
In the gluconate shunt, glucose is oxidized by glucose dehydrogenase (also called glucose oxidase) to furnish gluconate, the form in which Gluconic Acid (Dextronic acid) is present at physiological pH.


Subsequently, gluconate is phosphorylated by the action of gluconate kinase to produce 6-phosphogluconate, which is the second intermediate of the pentose phosphate pathway.
This gluconate shunt is mainly found in plants, algae, cyanobacteria and some bacteria, which all use the Entner-Doudoroff pathway to degrade glucose or gluconate; this generates 2-keto-3-deoxygluconate-6-phosphate, which is then cleaved to generate pyruvate and glyceraldehyde 3-phosphate.


Glucose dehydrogenase and gluconate kinase activities are also present in mammals, fission yeast, and flies.
Gluconic Acid (Dextronic acid) has been found to be a metabolite in Aspergillus.
Gluconic Acid (Dextronic acid) is a white solid with a weak odor of ammonia.


Gluconic Acid (Dextronic acid) sinks and mixes with water.
Gluconic Acid (Dextronic acid) is a gluconic acid having D-configuration.
Gluconic Acid (Dextronic acid) has a role as a chelator and a Penicillium metabolite.


Gluconic Acid (Dextronic acid) is a conjugate acid of a D-gluconate.
Gluconic Acid (Dextronic acid) is an enantiomer of a L-gluconic acid.
Gluconic Acid (Dextronic acid) is commonly found in salts with sodium and calcium.


Gluconic Acid (Dextronic acid) is a metabolite found in or produced by Escherichia coli.
Gluconic Acid (Dextronic acid) is a natural product found in Ascochyta medicaginicola, Tricholoma robustum, and other organisms with data available.
Gluconic Acid (Dextronic acid) is the carboxylic acid formed by the oxidation of the first carbon of glucose with antiseptic and chelating properties.


Gluconic Acid (Dextronic acid), found abundantly in plant, honey and wine, can be prepared by fungal fermentation process commercially.
Gluconic Acid (Dextronic acid) contains cyclic ester glucono delta lactone structure, which chelates metal ions and forms very stable complexes.
In alkaline solution, Gluconic Acid (Dextronic acid) exhibits strong chelating activities towards anions, i.e. calcium, iron, aluminium, copper, and other heavy metals.


Gluconic Acid (Dextronic acid) is a metabolite found in or produced by Saccharomyces cerevisiae.
Gluconic Acid (Dextronic acid) is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4CO2H.
A white solid, Gluconic Acid (Dextronic acid) forms the gluconate anion in neutral aqueous solution.


The salts of Gluconic Acid (Dextronic acid) are known as "gluconates".
Gluconic Acid (Dextronic acid), gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose.
Some drugs are injected in the form of gluconates.



USES and APPLICATIONS of GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) is mainly used for its leavening and acidity properties in food; chelating and perfuming agents in cosmetics products.
Gluconic Acid (Dextronic acid) can be used in industrial uses for chelating heavy metals.
Gluconic Acid (Dextronic acid) is used to maintain the cation-anion balance on electrolyte solutions.


Gluconic Acid (Dextronic acid) and its derivatives can used in formulation of pharmaceuticals, cosmetics and food products as additive or buffer salts.
Primary acid in honey; Gluconic Acid (Dextronic acid) is used in pharmaceutical and food products, for cleaning and pickling metals, as a sequestrant, in paint strippers, and in alkaline rust removers.


Gluconic Acid (Dextronic acid) is used as a chelating agent, high alkalinity bottle cleanser, and finish remover.
Gluconic Acid (Dextronic acid) is used in the tanning and textile industries.
Gluconic Acid (Dextronic acid) is used important intermediate in carbohydrate metabolism in mammals.


Gluconic Acid (Dextronic acid) is used for industrial cleaning, metal surface treatment, textile bleach stabilizing, aluminum processing, and as a chelating agent in cement set retarding, cleaning products, personal care products, pharmaceuticals, and foods.
Gluconic Acid (Dextronic acid) is used as a food additive, it acts as an acidity regulator.


Gluconic Acid (Dextronic acid) is used in metal cleaning formulations for rust and stains (mineral deposits) removal on metal surfaces.
Gluconic Acid (Dextronic acid) is used in high-performance metal degreasers.
Gluconic Acid (Dextronic acid) is used in textile industries as stabilizers for dye baths and bleach baths.


Gluconic Acid (Dextronic acid) is used in leather tanning and dyeing processes.
Gluconic Acid (Dextronic acid) is mixed in mortar and concrete admixes as a retarder as well as a plasticizer.
Cosmetics uses of Gluconic Acid (Dextronic acid): Gluconic Acid (Dextronic acid) can be used as a chelating and perfuming agent in cosmetic and personal care products.


Gluconic Acid (Dextronic acid) as well as its salts are excellently absorbed in the intestine, are almost non-toxic and are used in food technology, medicine (sodium, potassium and calcium gluconate) and industry (tanning agents).
The consumption of large amounts of Gluconic Acid (Dextronic acid) can cause diarrhoea.


Gluconic Acid (Dextronic acid) and its salts, sodium (E 576), potassium (E 577), calcium gluconate (E 578) are used in foods as artificial acidity regulators and as stabilizers.
Gluconic Acid (Dextronic acid) is used in desserts, fruit and vegetable products, and soft drinks.


Gluconic Acid (Dextronic acid) occurs naturally in fruit, honey and wine and is used as a food additive, an acidity regulator.
Gluconic Acid (Dextronic acid) is also used in cleaning products where it helps cleaning up mineral deposits.
Gluconic Acid (Dextronic acid) is a strong chelating agent, especially in alkaline solution.


Gluconic Acid (Dextronic acid) chelates the anions of calcium, iron, aluminium, copper, and other heavy metals.
Glucono delta lactone is a cyclic ester of Gluconic Acid (Dextronic acid).
Gluconic Acid (Dextronic acid) is used in the preparation of cold set gels, and hydrogels.


Gluconic Acid (Dextronic acid) is used for industrial cleaning, textile bleach stabilizing, aluminium processing, and as a chelating agent in cement set retarding.
Gluconic Acid (Dextronic acid) is also used for metal surface treatment, cleaning products, personal care products, pharmaceuticals, and as a food additive.


Calcium gluconate is used in the treatment of patients with hypocalcemia, and its gel is used in the treatment of burns from hydrofluoric acid.
Quinine gluconate which is a salt of Gluconic Acid (Dextronic acid) and quinine is used in the treatment of malaria.
Ferrous gluconate, or iron (II) gluconate, injections have been proposed in the past to treat anaemia, which occurs due to iron deficiency.


Gluconic Acid (Dextronic acid) aqueous solution is used as a medium for organic synthesis.
Gluconic Acid (Dextronic acid) is a chemical used in glycolytic pathway studies.
Gluconic Acid (Dextronic acid) is an acidulant that is a mild organic acid which is the hydrolyzed form of glucono-delta-lactone.


Gluconic Acid (Dextronic acid) is prepared by the fermentation of dextrose, whereby the physiological d-form is produced.
Gluconic Acid (Dextronic acid) is soluble in water with a solubility of 100 g/100 ml at 20°c.
Gluconic Acid (Dextronic acid) has a mild taste and at 1% has a ph of 2.8.


Gluconic Acid (Dextronic acid) functions as an antioxidant and enhances the function of other antioxidants.
In beverages, syrups, and wine, Gluconic Acid (Dextronic acid) can eliminate calcium turbidities.
Gluconic Acid (Dextronic acid) is used as a leavening component in cake mixes, and as an acid component in dry-mix desserts and dry beverage mixes.


Gluconic Acid (Dextronic acid) occurs naturally in fruit, honey, and wine.
As a food additive Gluconic Acid (Dextronic acid) is an acidity regulator.
Gluconic Acid (Dextronic acid) is also used in cleaning products.


Gluconic Acid (Dextronic acid) can also be used as a food additive to regulate acidity and a cleaning agent in alkaline solution.
Gluconic Acid (Dextronic acid)'s calcium salt, calcium gluconate can be used to treat burns from hydrofluoric acid and avoid necrosis of deep tissues as well as treating the verapamil poisoning and hypocalcemia in hospitalized patient.


Some salts of Gluconic Acid (Dextronic acid) can also be used to treat malaria (quinidine gluconate) and anemia (ferrous gluconate).
In microbiology, Gluconic Acid (Dextronic acid) is a common carbon source that can be supplemented to the medium for cell growth.
Gluconic Acid (Dextronic acid) and its derivatives are used in pharmaceuticals, cosmetics, cleaning solutions, and food products.


Gluconic Acid (Dextronic acid) has many industrial uses.
Gluconic Acid (Dextronic acid) is used as a drug as part of electrolyte supplementation in total parenteral nutrition.
Gluconic Acid (Dextronic acid) is also used in cleaning products where it helps clean up mineral deposits.


Gluconic Acid (Dextronic acid) is used to maintain the cation-anion balance on electrolyte solutions.
In humans, Gluconic Acid (Dextronic acid) is involved in the metabolic disorder called the transaldolase deficiency.
Gluconic Acid (Dextronic acid) occurs naturally in fruit, honey and wine and is used as a food additive, an acidity regulator.


-Industrial uses of Gluconic Acid (Dextronic acid):
The power of chelating heavy metals is stronger than that of EDTA, such as the chelation of calcium, iron, copper, and aluminium in alkaline conditions.
This property can be utilized in detergents, electroplating, textiles and so on.


-Food uses of Gluconic Acid (Dextronic acid):
The following food may contain with Gluconic Acid (Dextronic acid):
*Bakery goods: as a leavening acid in leavening agent to increase dough volume by producing gas by the reaction with baking soda.

*Dairy products: as a chelating agent and prevent milkstone.
Some food and beverage: as an acidity regulator to impart a mild organic acid and adjust pH level and also as a preservative and an antifungal agent.
Also, Gluconic Acid (Dextronic acid) can be used to clean aluminium cans.


-Animal Nutrition uses of Gluconic Acid (Dextronic acid):
Gluconic Acid (Dextronic acid) functions as a weak acid in piglet feed, poultry feed and aquaculture to comfort digestive and promote growth, also to increase the production of butyric acid and SCFA (Short-chain fatty acid).


-Medicine uses of Gluconic Acid (Dextronic acid):
In medicine, gluconate is used most commonly as a biologically neutral carrier of Zn2+, Ca2+, Cu2+, Fe2+, and K+ to treat electrolyte imbalance.
Calcium gluconate, in the form of a gel, is used to treat burns from hydrofluoric acid; calcium gluconate injections may be used for more severe cases to avoid necrosis of deep tissues, as well as to treat hypocalcemia in hospitalized patients.

Gluconate is also an electrolyte present in certain solutions, such as "plasmalyte a", used for intravenous fluid resuscitation.
Quinine gluconate is a salt of Gluconic Acid (Dextronic acid) and quinine, which is used for intramuscular injection in the treatment of malaria.
Ferrous gluconate injections have been proposed in the past to treat anemia.



CHEMICAL PROPERTIES OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) is an acid sugar composed of white crystals with a milk-acidic taste.
In aqueous solutions, Gluconic Acid (Dextronic acid) is in equilibrium with gamma- and delta-gluconolactones.

Gluconic Acid (Dextronic acid) is prepared by enzymatic oxidation of glucose and strains of the microorganisms used to supply the enzyme action are nonpathogenic and nontoxicogenic to man or other animals.
Gluconic Acid (Dextronic acid) is used as a component of bottle rinsing formulations, at levels not to exceed good manufacturing practice.



PHYSICAL PROPERTIES OF GLUCONIC ACID (DEXTRONIC ACID):
The chemical structure of Gluconic Acid (Dextronic acid) consists of a six-carbon chain with five hydroxyl groups terminating in a carboxylic acid group.
In aqueous solution, Gluconic Acid (Dextronic acid) exists in equilibrium with the cyclic ester glucono delta-lactone.



PKa & PH OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) is a weak carboxylic acid with a dissociation constant pKa 3.6.
Gluconic Acid (Dextronic acid) dissociates a proton and a gluconate ion (conjugation).
Gluconic Acid (Dextronic acid)'s aqueous solution has a neutral pH.



PROPERTIES OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid)'s food grade is commonly 50% solution in water with colourless to light yellow color, and contains about 5% glucono delta-lactone at room temperature.
As in aqueous solution, Gluconic Acid (Dextronic acid) exists in a stable equilibrium with the cyclic ester – GDL (glucono delta-lactone).



ALTERNATIVE PARENTS OF GLUCONIC ACID (DEXTRONIC ACID):
*Medium-chain hydroxy acids and derivatives
*Medium-chain fatty acids
*Hydroxy fatty acids
*Beta hydroxy acids and derivatives
*Monosaccharides
*Alpha hydroxy acids and derivatives
*Secondary alcohols
*Polyols
*Monocarboxylic acids and derivatives
*Carboxylic acids
*Primary alcohols
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF GLUCONIC ACID (DEXTRONIC ACID):
*Gluconic_acid
*Medium-chain hydroxy acid
*Medium-chain fatty acid
*Beta-hydroxy acid
*Hydroxy fatty acid
*Alpha-hydroxy acid
*Fatty acyl
*Fatty acid
*Hydroxy acid
*Monosaccharide
*Secondary alcohol
*Carboxylic acid derivative
*Carboxylic acid
*Polyol
*Monocarboxylic acid or derivatives
*Alcohol
*Carbonyl group
*Primary alcohol
*Organic oxide
*Hydrocarbon derivative
*Aliphatic acyclic compound



BIOTECHNOLOGICAL PRODUCTION OF GLUCONIC ACID (DEXTRONIC ACID):
Currently, Gluconic Acid (Dextronic acid) is commercially produced by submerged fed-batch cultivations of Aspergillus niger using glucose as substrate.
Gluconic Acid (Dextronic acid) concentration and yields of the product depend on the fermentation conditions.
For optimal gluconic acid production, high glucose concentrations (110–250 g.L-1), low concentrations of nitrogen and phosphorus in the medium, a limitation of metal ion concentrations, a pH value in the range of 4.5–6.5, and high aeration rates for the oxygen supply are needed.

Much research has been carried out to find new ways for cheaper production.
Different microorganisms have been studied (e.g. G. oxydans, Z. mobilis, A. methanolicous, and P. fluorescence.
Moreover, new microbial strains have been developed by mutagenesis or genetic engineering.

Additionally, the fermentation process and recovery have been optimized.
New inexpensive substrates (e.g. cornstarch, grape or banana must, figs, and cheese whey) have been tested.
One example of a new and efficient production process of gluconic acid is the cultivation of Aureobasidium pullulans growing on glucose.

Using a continuous process with biomass retention by crossover filtration, a product concentration of 375 g.L-1, a yield of 0.83 g of gluconic acid per gram of glucose, and a productivity of 17 g.L-1.h-1 could be achieved at a residence time of 22 h.
In this process, 100 % of the glucose is converted.
This process might be interesting for industrial applications.



STRUCTURE OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) is an organic compound that has a molecular formula of C6H12O7 and the condensed structural formula HOCH2(CHOH)4COOH.
The below figure is the structure of Gluconic Acid (Dextronic acid), where we can observe that it consists of a 6-carbon chain, with 5 hydroxyl groups placed in the same way as in the open-chained form of glucose, ending with the carboxylic acid group.



PREPARATION OF GLUCONIC ACID (DEXTRONIC ACID):
At present, Gluconic Acid (Dextronic acid) is synthesized in commercial quantities by the fermentative oxidation of the aldehyde group in glucose from corn, which is carried out by Aspergillus niger, Aspergillus fumaricus, Aspergillus acetic, Penicillium chryrosogenum, and other pencillia.
Gluconic Acid (Dextronic acid) and sorbitol are formed by the Cannizaro reaction on glucose, under alkaline conditions.

Gluconic Acid (Dextronic acid) may also be prepared from the electrolytic oxidation of glucose in an alkaline medium.
Or Gluconic Acid (Dextronic acid) can also be prepared by the chemical oxidation of glucose by a hypochlorite or hypobromite solution, or by directly oxidizing glucose in the presence of the palladium catalyst.

Gluconic Acid (Dextronic acid) is a non-toxic compound that can be found naturally in honey, wine, fruits, etc.
Gluconic Acid (Dextronic acid) is a carboxylic acid that can be formed by the oxidation of the first carbon of glucose with antiseptic and chelating properties.

Gluconic Acid (Dextronic acid) can also be synthesized by hydrolysis of α-D-glucose with a mixture of bromide and sulfuric acid.
Gluconic Acid (Dextronic acid) can also be prepared by gamma-irradiation of D-glucose.
Gluconic Acid (Dextronic acid) is produced by oxidizing glucose in the presence of bromine water.



CHEMICAL PROPERTIES OF GLUCONIC ACID (DEXTRONIC ACID):
Calcium gluconate is formed by the neutralization of Gluconic Acid (Dextronic acid) with lime or calcium carbonate.
By heating ferrous carbonate with the proper quantity of Gluconic Acid (Dextronic acid) in an aqueous solution, ferrous gluconate or iron (II) gluconate can be produced.
Gluconic Acid (Dextronic acid) partially converts to an equilibrium mixture with gamma and delta gluconolactone in water.



OCCURRENCE OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) occurs naturally in fruit, honey, kombucha tea, and wine.
As a food additive ( E574 ), Gluconic Acid (Dextronic acid) is an acidity regulator.
Gluconic Acid (Dextronic acid) is also used in cleaning products where it dissolves mineral deposits especially in alkaline solution.

The gluconate anion chelates Ca2+,Fe2+, Al3+, and other metals.
In 1929 Horace Terhune Herrick developed a process for producing the salt by fermentation.
Calcium gluconate, in the form of a gel, is used to treat burns from hydrofluoric acid; calcium gluconate injections may be used for more severe cases to avoid necrosis of deep tissues.

Quinine gluconate is a salt between gluconic acid and quinine, which is used for intramuscular injection in the treatment of malaria.
Zinc gluconate injections are used to neuter male dogs.
Iron gluconate injections have been proposed in the past to treat anemia.



STRUCTURAL FORMULA OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) structure features 6 carbon chain along with 5 hydroxyl groups placed in the general open-chain format of glucose, ending with the carboxylic acid group.
Gluconic Acid (Dextronic acid) exists in balance state in the aqueous state in the presence of cyclic ester glucono delta-lactone.
The structural formula of Gluconic Acid (Dextronic acid) is as shown below in the picture.

Gluconic Acid (Dextronic acid), a mild organic acid derived from sugar, mainly used as an acidity regulator and chelating agent in food with the European food additive number E574.
Gluconic Acid (Dextronic acid) is also used to produce gluconates (E576, 577, 578, 579, 585) and glucono delta-lactone (E575) to be used in different food applications and other fields.



NATURAL SOURCES OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) is naturally present in fruit, wine, honey, rice, meat and in kombucha fermentation.



HOW IS GLUCONIC ACID (DEXTRONIC ACID) MADE?
Generally, Gluconic Acid (Dextronic acid) is produced by oxidation of D-glucose (derived from starch hydrolysis) with different manufacturing processes:
*Bromine water
*Microorganisms, such as Aspergillus niger and Acetobactor suboxydans
*Enzymes derived from microorganisms



WHAT ARE GLUCONATES?
Gluconates usually refer to the salts of Gluconic Acid (Dextronic acid) that are commonly made from the reaction between Gluconic Acid (Dextronic acid) and the corresponding metal carbonate salts.
The following are six common types of gluconates and their uses/functions in food:

*Calcium gluconate: functions as a firming agent, formulation aid, sequestrant, stabilizer or thickener and texturizer that can be used in baked goods, dairy products, gelatins, puddings and sugar substitutes.
*Sodium gluconate: a sequestrant .
*Copper gluconate: works as a nutrient supplement and a synergist, may be used in infant formula.
*Ferrous gluconate: a nutrient supplement that may be used in infant formula, also can be acted as a food color.
*Manganese gluconate: a nutrient supplement that can be used in baked goods, dairy and meat products, poultry products, and infant formulas.
*Zinc gluconate: nutrient.



WHAT ARE THE HEALTH BENEFITS OF GLUCONIC ACID (DEXTRONIC ACID)?
Urinary stones prevention: an early study showed that Gluconic Acid (Dextronic acid) can prevent urinary stones.
Intestinal microflora activity promotion: a study in piglets exhibited that Gluconic Acid (Dextronic acid) had a positive effect on the intestinal microflora and may improve piglets growth.



FORMULA OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid), an organic compound known as Dextronic acid, is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.
Gluconic Acid (Dextronic acid)'molecular formula is C6H12O7 and its condensed structural formula is HOCH2(CHOH)4COOH.



STRUCTURE OF GLUCONIC ACID (DEXTRONIC ACID):
The structure of Gluconic Acid (Dextronic acid) is shown in the above image.
Gluconic Acid (Dextronic acid) has a 6-carbon chain, five hydroxyl groups arranged similarly to how they are in the open-chained form of glucose, and a carboxylic acid group at the end.



CHEMICAL STRUCTURE OF GLUCONIC ACID (DEXTRONIC ACID):
The chemical structure of Gluconic Acid (Dextronic acid) consists of a six-carbon chain, with five hydroxyl groups positioned in the same way as in the open-chained form of glucose, terminating in a carboxylic acid group.
Gluconic Acid (Dextronic acid) is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.



PRODUCTION OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) is typically produced by the aerobic oxidation of glucose in the presence of the enzyme glucose oxidase.
The conversion produces gluconolactone and hydrogen peroxide.
The lactone spontaneously hydrolyzes to Gluconic Acid (Dextronic acid) in water.

C6H12O6 + O2 → C6H10O6 + H2O2
C6H10O6 + H2O → C6H12O7
Variations of glucose (or other carbohydrate-containing substrate) oxidation using fermentation or noble metal catalysis.

Gluconic Acid (Dextronic acid) was first prepared by Hlasiwetz and Habermann in 1870 and involved the chemical oxidation of glucose.
In 1880, Boutroux prepared and isolated Gluconic Acid (Dextronic acid) using the glucose fermentation.



OCCURRENCE AND USES OF GLUCONIC ACID (DEXTRONIC ACID):
Gluconic Acid (Dextronic acid) occurs naturally in fruit, honey, and wine.
As a food additive (E574), Gluconic Acid (Dextronic acid) is now known as an acidity regulator.

The gluconate anion chelates Ca2+, Fe2+, K+, Al3+, and other metals, including lanthanides and actinides.
Gluconic Acid (Dextronic acid) is also used in cleaning products, where it dissolves mineral deposits, especially in alkaline solution.
Zinc gluconate injections are used to neuter male dogs.

Gluconate is also used in building and construction as a concrete admixture (retarder) to slow down the cement hydration reactions, and to delay the cement setting time.
It allows for a longer time to lay the concrete, or to spread the cement hydration heat over a longer period of time to avoid too high a temperature and the resulting cracking.

Retarders are mixed in to concrete when the weather temperature is high or to cast large and thick concrete slabs in successive and sufficiently well-mixed layers.
Gluconic Acid (Dextronic acid) finds application as a medium for organic synthesis.



PHYSICAL and CHEMICAL PROPERTIES of GLUCONIC ACID (DEXTRONIC ACID):
Molecular Weight: 196.16 g/mol
XLogP3-AA: -3.4
Hydrogen Bond Donor Count: 6
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 5
Exact Mass: 196.05830272 g/mol
Monoisotopic Mass: 196.05830272 g/mol
Topological Polar Surface Area: 138 Ų
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 170
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1

Compound Is Canonicalized: Yes
Chemical formula: C6H12O7
Molar mass: 196.155 g·mol−1
Appearance: Colorless crystals
Melting point: 131 °C (268 °F; 404 K)
Solubility in water: 316 g/L
Acidity (pKa): 3.86
Color: White to Yellow
Beilstein: 03, 542
Merck Index: 15, 4492
Formula Weight: 196.16
Percent Purity: 49 to 55% (Titrimetry other)
Density: 1.23 g/mL
Physical Form: Crystals or Crystalline Powder
Specific Gravity: 1.22 to 1.25 (20°C)
Chemical Name or Material: Gluconic acid

Physical state: Liquid
Color: Light brown
Odor: Slightly sourish
Melting point/freezing point: Not available
Initial boiling point and boiling range: 105 - 106 °C at 1.013 hPa
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: Not available
Autoignition temperature: Not available
Decomposition temperature: Distillable in an undecomposed state at normal pressure
pH: 2.2 at 500 g/l at 20 °C
Viscosity: Not available
Water solubility at 20 °C: Soluble
Partition coefficient: n-octanol/water - Not available
Vapor pressure: Not available
Density: 1.24 g/cm3 at 20 °C

Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not classified as explosive
Oxidizing properties: None
Other safety information: Not available
Molecular Weight: 194.13900 g/mol
Molecular Formula: C6H10O7
Purity: 95%
Solubility: Water, 1e+006 mg/L @ 25 °C (estimated)
Assay: 0.98
EINECS: 209-401-7
Grade: Industrial grade
Chemical Formula: C6H12O7
Average Molecular Weight: 196.1553 g/mol
Monoisotopic Molecular Weight: 196.058302738 g/mol

IUPAC Name: (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
Traditional Name: Gluconate
CAS Registry Number: 526-95-4
SMILES: OCC@@HC@@HC@HC@@HC(O)=O
InChI Identifier: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1
InChI Key: RGHNJXZEOKUKBD-SQOUGZDYSA-N
Melting point: 15 °C
Boiling point: 102 °C
Alpha: D20 -6.7° (c = 1)
Density: 1.23
Refractive index: 1.4161
Storage temperature: Store below +30°C
Solubility: DMSO (Slightly), Methanol (Slightly), Water
Form: Crystalline Powder or Crystals

pKa: pK (25°) 3.60
Color: White to light yellow
Specific Gravity: 1.234
Odor: Commercial 50 aq. soln. lt. amber, faint odor of vinegar
Optical activity: [α]/D +9.0 to 15.5°
Water Solubility: Soluble in water
Appearance: Colourless crystals
Taste: Mild acid taste
Molar mass: 196.155 g/mol
IUPAC Name: D-Gluconic acid
Systematic IUPAC name: (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid
Chemical Formula: C6H12O7
CAS DataBase Reference: 526-95-4
EPA Substance Registry System: D-Gluconic acid (526-95-4)
Hydrogen bond donor count: 6
Hydrogen bond acceptor count: 7
Rotatable Bond Count: 5
PSA: 138.45000

XLogP3: -3.4
Appearance: Ammonium gluconate is a white solid with a weak odor of ammonia.
Density: 1.24 g/cm3 @ Temp: 25 °C
Boiling Point: 102ºC
Flash Point: 375.2ºC
Refractive Index: 1.4161
Water Solubility: Solubility in water, g/100ml at 25°C: 100 (good)
Storage Conditions: Store at RT.
Molecular form: C6H12O7
Appearance: Clear Colorless to Pale Yellow Solution
Mol. Weight: 196.16
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: NA



FIRST AID MEASURES of GLUCONIC ACID (DEXTRONIC ACID):
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GLUCONIC ACID (DEXTRONIC ACID):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent and neutralising material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of GLUCONIC ACID (DEXTRONIC ACID):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLUCONIC ACID (DEXTRONIC ACID):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,40 mm
Break through time: > 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: > 30 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of GLUCONIC ACID (DEXTRONIC ACID):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Recommended storage temperature see product label.



STABILITY and REACTIVITY of GLUCONIC ACID (DEXTRONIC ACID):
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available


GLUCOPURE FOAM
1.1. Product identifier Trade name GLUCOPURE FOAM Material number: 275450 Chemical nature: Glucamide in aqueous-glycolic solution INCI name: Cocoyl Methyl Glucamide 1.2. Relevant identified uses of the substance or mixture and uses advised against 2.1 Classification of the substance or mixture Classification (REGULATION (EC) No 1272/2008) Serious eye damage, Category 1 H318: Causes serious eye damage. 2.2 Label elements Labelling (REGULATION (EC) No 1272/2008) Hazard pictograms : Signal word : Danger Hazard statements : H318 Causes serious eye damage. Precautionary statements : Prevention: P280 Wear eye protection/ face protection. Response: P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. Hazardous components which must be listed on the label: D-Glucitol, 1-deoxy-1-(methylamino)-, N-(C8-16 (even numbered) and C18 unsaturated acyl) deriv. 2.3 Other hazards This substance/mixture contains no components considered to be either persistent,bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.No additional hazards are known except those derived from the labelling. 3.2 GLUCOPURE FOAM Mixtures Hazardous components Chemical name CAS-No. EC-No. Index-No. Registration number Classification Concentration (% w/w) D-Glucitol, 1-deoxy-1- (methylamino)-, N-(C8-16 (even numbered) and C18 unsaturated acyl) deriv. Not Assigned 01-2120041462-67- 0000 Eye Dam. 1; H318 >= 30 - < 50 4.1 GLUCOPURE FOAM Description of first aid measures General advice : Remove/Take off immediately all contaminated clothing.Get medical advice/ attention if you feel unwell. If inhaled : If inhaled, remove to fresh air.Get medical advice/ attention. In case of skin contact : In case of contact, immediately flush skin with soap and plenty of water. In case of eye contact : In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If swallowed : If swallowed do not induce vomiting,seek medical advice and show safety datasheet or label 4.2 Most important symptoms and effects, both acute and delayed Symptoms : irritant effects Risks : Causes serious eye damage. 4.3 Indication of any immediate medical attention and special treatment needed Treatment : Treat symptomatically. 5.1 GLUCOPURE FOAM Extinguishing media Suitable extinguishing media : Water spray jet Alcohol-resistant foam Dry powder Carbon dioxide (CO2) Unsuitable extinguishing media: High volume water jet 5.2 Special hazards arising from the substance or mixture Specific hazards during firefighting : In case of fire hazardous decomposition products may be produced such as: Nitrogen oxides (NOx) Carbon monoxide 5.3 Advice for firefighters Special protective equipment for firefighters : Self-contained breathing apparatus Further information : Wear suitable protective equipment. 6.1 GLUCOPURE FOAM Personal precautions, protective equipment and emergency procedures Personal precautions : Wear suitable protective equipment. Ensure adequate ventilation. 6.2 Environmental precautions Environmental precautions : The product should not be allowed to enter drains, water courses or the soil. 6.3 Methods and material for containment and cleaning up Methods for cleaning up : Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Treat recovered material as described in the section "Disposal considerations". 6.4 Reference to other sections Information regarding Safe handling, see chapter 7., For personal protection see section 8., For disposal considerations see section 13. 7.1 GLUCOPURE FOAM Precautions for safe handling Advice on safe handling : Provide adequate ventilation. Advice on protection against fire and explosion: Observe the general rules of industrial fire protection Hygiene measures : Wash hands before breaks and at the end of workday. Use protective skin cream before handling the product. Take off immediately all contaminated clothing and wash it before reuse. 7.2 Conditions for safe storage, including any incompatibilities Further information on storage conditions : Keep containers tightly closed in a cool, well-ventilated place. Store in cool place. Store in a dry place. 7.3 Specific end use(s) Specific use(s) : No further recommendations. 8.1 GLUCOPURE FOAM Control parameters Derived No Effect Level (DNEL) according to Regulation (EC) No. 1907/2006: Substance name-End Use-Exposure routes-Potential health effects-Value Propylene Glycol CAS-No.: 57-55-6-Workers-Inhalation-Long-term systemic effects-168 mg/m3 Remarks: DNEL-Workers-Inhalation-Long-term local effects-10 mg/m3 Remarks: DNEL-Consumers-Inhalation Long-term systemic effects-50 mg/m3 Remarks: DNEL-Consumers-Inhalation Long-term local effects-10 mg/m3 Remarks: DNEL-Consumers-Skin contact Long-term systemic effects-213 mg/m3 Consumers-Ingestion Long-term systemic effects-85 mg/m3 D-Glucitol, 1-deoxy-1-(methylamino)-, N-(C8-16 (even numbered) and C18 unsaturated acyl) deriv.Workers Inhalation Long-term systemic effects-10,58 mg/m3 Remarks: DNEL-Workers-Skin contact Long-term systemic effects-30 mg/kg bw/day Predicted No Effect Concentration (PNEC) according to Regulation (EC) No. 1907/2006: Substance name Environmental Compartment Value Propylene Glycol CAS-No.: 57-55-6 Fresh water 260 mg/l Marine water 26 mg/l Water (intermittent release) 183 mg/l Sewage treatment plant 20000 mg/l Fresh water sediment 572 mg/kg dry weight (d.w.) Marine sediment 57,2 mg/kg dry weight (d.w.) Soil 50 mg/kg dry weight (d.w.) D-Glucitol, 1-deoxy-1-(methylamino)-, N-(C8-16 (even numbered) and C18 unsaturated acyl) deriv. Fresh water 0,32 mg/l Marine water 0,032 mg/l Water (intermittent release) 0,059 mg/l Fresh water sediment 43,4 mg/kg dry weight (d.w.) Marine sediment 4,3 mg/kg dry weight (d.w.) Sewage treatment plant 0,8 mg/l Soil 36,6 mg/kg dry weight (d.w.) 8.2 GLUCOPURE FOAM Exposure controls Personal protective equipment Eye protection : Depending on the risk, wear sufficient eye protection (safety glasses with side protection or goggles, and if necessary, face shield.) Hand protection Break through time : 480 min Glove thickness : 0,7 mm Remarks : Long-term exposure Impervious butyl rubber gloves Break through time : 30 min Glove thickness : 0,4 mm Remarks : For short-term exposure (splash protection): Nitrile rubber gloves. Remarks : These types of protective gloves are offered by various manufacturers. Please note the manufacturers´ detailed statements, especially about the minimum thickness and the minimum breakthrough time. Consider also the particular working conditions under which the gloves are being used. Skin and body protection : Wear suitable protective equipment. Respiratory protection : Use respiratory protection in case of insufficient exhaust ventilation or prolonged exposure Full mask to standard DIN EN 136 Filter A (organic gases and vapours) to standard DIN EN 141 The use of filter apparatus presupposes that the environment atmosphere contains at least 17% oxygen by volume, and does not exceed the maximum gas concentration, usually 0.5% by volume. Relevant guidelines to be considered include EN 136/141/143/371/372 as well as other national regulations. Protective measures : Observe the usual precautions for handling chemicals. Avoid contact with skin and eyes. 9.1 GLUCOPURE FOAM Information on basic physical and chemical properties GLUCOPURE FOAM Appearance : paste GLUCOPURE FOAM Odour : characteristic GLUCOPURE FOAM Odour Threshold : not tested. GLUCOPURE FOAM pH : 8,5 - 9,5 (35 °C) GLUCOPURE FOAM Concentration: 10 g/l GLUCOPURE FOAM Melting point : approx. 32 °C GLUCOPURE FOAM Boiling point : approx. 100 °C Based on water-content. GLUCOPURE FOAM Flash point : not tested. GLUCOPURE FOAM Evaporation rate : not tested. GLUCOPURE FOAM Burning number : Not applicable GLUCOPURE FOAM Upper explosion limit : not tested. GLUCOPURE FOAM Lower explosion limit : not tested. GLUCOPURE FOAM Vapour pressure : 2,3 hPa (25 °C) Method: EEC 84/449 A.4 Corresp. to vapour pressure of water GLUCOPURE FOAM Relative vapour density : not tested. GLUCOPURE FOAM Density : approx. 1,046 g/cm3 (50 °C) Method: DIN 51757 GLUCOPURE FOAM Bulk density : Not applicable GLUCOPURE FOAM Solubility(ies) Water solubility : soluble (40 °C) GLUCOPURE FOAM Solubility in other solvents : 39 g/l Data corresponds to that of the active component (20 °C) Solvent: 1-octanol Method: OECD Test Guideline 105 GLUCOPURE FOAM Auto-ignition temperature : not tested. GLUCOPURE FOAM Decomposition temperature : > 200 °C Heating rate : 3 K/min Method: DSC GLUCOPURE FOAM Viscosity GLUCOPURE FOAM Viscosity, dynamic : not tested. GLUCOPURE FOAM Viscosity, kinematic : not tested. GLUCOPURE FOAM Explosive properties : Not explosive GLUCOPURE FOAM Oxidizing properties : There are no chemical groups associated with oxidising GLUCOPURE FOAM properties present in the molecule. 9.2 GLUCOPURE FOAM Other information Minimum ignition energy : not tested. Particle size : Not applicable Self-ignition : > 135 °C Method: EC A.16 10.1 GLUCOPURE FOAM Reactivity See section 10.3. "Possibility of hazardous reactions" 10.2 Chemical stability Stable under normal conditions. 10.3 Possibility of hazardous reactions Hazardous reactions : No dangerous reaction known under conditions of normal use. 10.4 Conditions to avoid Conditions to avoid : Keep away from heat and sources of ignition. 10.5 Incompatible materials Materials to avoid : Strong acids and oxidizing agents 10.6 Hazardous decomposition products When handled and stored appropriately, no dangerous decomposition products are known 11.1 GLUCOPURE FOAM Information on toxicological effects Acute toxicity Product: Acute oral toxicity : LD50 (Rat): > 2.500 mg/kg Method: OECD Test Guideline 423 Remarks: The values mentioned are those of the active ingredient. Acute inhalation toxicity : Remarks: not tested. Acute dermal toxicity : LD50 (Rabbit): > 2.000 mg/kg Method: OECD Test Guideline 402 Remarks: By analogy with a product of similar composition Skin corrosion/irritation Product: Species: EPISKIN Human Skin Model Test Method: OECD Test Guideline 439 Result: No skin irritation Remarks: The values mentioned are those of the active ingredient. Serious eye damage/eye irritation Product: Species: rabbit eye Method: OECD Test Guideline 405 Result: Risk of serious damage to eyes. Respiratory or skin sensitisation Product: Method: OECD Test Guideline 406 Result: non-sensitizing Germ cell mutagenicity Product: Genotoxicity in vitro : Test Type: HGPRT assay Species: V79 cells (embryonic lung fibroblasts) of the Chinese hamster Method: OECD Test Guideline 476 Result: negative Remarks: Information refers to the main component. Genotoxicity in vivo : Test Type: Micronucleus test Species: Mouse Method: OECD Test Guideline 474 Result: negative Remarks: Information refers to the main component. Germ cell mutagenicityAssessment : Not mutagenic in Ames Test Carcinogenicity Product: Carcinogenicity - Assessment : No information available. Reproductive toxicity Product: Reproductive toxicity - Assessment : No information available. No information available. STOT - single exposure Product: Remarks: not tested. STOT - repeated exposure Product: Remarks: not tested. Repeated dose toxicity Product: Species: Rat NOAEL: 750 mg/kg Exposure time: 28 d Method: OECD Test Guideline 407 Remarks: Information refers to the main component. Aspiration toxicity Product: no data available Further information Product: Remarks: The product has not been tested. The information is derived from the properties of the individual components. 12.1 GLUCOPURE FOAM Toxicity Product:Toxicity to fish : LC50 (Danio rerio (zebra fish)): 7,5 mg/l Exposure time: 96 h Method: OECD Test Guideline 203 Toxicity to daphnia and other aquatic invertebrates: EC50 (Daphnia magna (Water flea)): 5,91 mg/l Exposure time: 48 h Method: OECD Test Guideline 202 Remarks: The values mentioned are those of the active ingredient. Toxicity to algae : EC50 (Selenastrum capricornutum (green algae)): 30 mg/l Exposure time: 72 h Method: OECD Test Guideline 201 NOEC (Selenastrum capricornutum (green algae)): 5,6 mg/l Remarks: The values mentioned are those of the active ingredient. Toxicity to fish (Chronic toxicity) : NOEC: 4,8 mg/l Exposure time: 35 d Species: Pimephales promelas (fathead minnow) Remarks: The values mentioned are those of the active ingredient. Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity) : NOEC: 3,24 mg/l Exposure time: 21 d Species: Daphnia magna (Water flea) Method: OECD Test Guideline 211 Remarks: The values mentioned are those of the active ingredient. Toxicity to microorganisms : EC50 (activated sludge): 171 mg/l Exposure time: 3 h Method: OECD Test Guideline 209 12.2 Persistence and degradability Product: Biodegradability : Remarks: Not applicable 12.3 Bioaccumulative potential Product: Bioaccumulation : Bioconcentration factor (BCF): 58 Method: calculated Remarks: Low potential for bioaccumulation (log Pow < 3). 12.4 Mobility in soil Product: Distribution among environmental compartments: Remarks: not tested. 12.5 Results of PBT and vPvB assessment Product: Assessment : This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.. 12.6 Other adverse effects Product: Additional ecological information : The product has not been tested. The information is derived from the properties of the individual components. 13.1 GLUCOPURE FOAM Waste treatment methods Product : In accordance with local authority regulations, take to special waste incineration plant Contaminated packaging : Packaging that cannot be cleaned should be disposed of as product waste Section 14.1. to 14.5. ADR not restricted ADN not restricted RID not restricted IATA not restricted IMDG not restricted 14.6. Special precautions for user See sections 6 to 8 of this Safety Data Sheet. 14.7. Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code (International Bulk Chemicals Code) No transport as bulk according IBC - Code. 15.1 GLUCOPURE FOAM Safety, health and environmental regulations/legislation specific for the substance or mixture REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). : Not applicable Regulation (EC) No 1005/2009 on substances that deplete the ozone layer : Not applicable Regulation (EC) No 850/2004 on persistent organic pollutants : Not applicable Other regulations: Apart from the data/regulations specified in this chapter, no further information is available concerning safety, health and environmental protection. The surfactant(s) contained in this mixture complies(comply) with the biodegradability criteria as laid down in Regulation (EC) No.648/2004 on detergents. Data to support this assertion are held at the disposal of the competent authorities of the Member States and will be made available to them, at their direct request or at the request of a detergent manufacturer. Take note of Dir 94/33/EC on the protection of young people at work. Occupational restrictions for pregnant and breast feeding women 15.2 Chemical safety assessment No Chemical Safety Assessment (CSA) is yet available for the substance, or for the component substances, contained in this product.
GLUCOPURE WET
Nonionic surfactant and solubilizer for hard surface cleaners GLUCOPURE WET Composition N-C8/10-acyl-N-methyl-glucamin GLUCOPURE WET Product properties GLUCOPURE WET Appearance (20 °C) Yellowish liquid GLUCOPURE WET Gardener colour Max. 5 GLUCOPURE WET Active substance Approx. 50 % GLUCOPURE WET Viscosity at 20 °C [mPas] Approx. 200 GLUCOPURE WET Density at 25 °C [g/cm3] Approx.1.081 GLUCOPURE WET pH (10 % t. q. aqueous solution) Approx. 8.5 GLUCOPURE WET Propylene Glycol Approx. 5.0 % GLUCOPURE WET HLB (Griffin) 13 Profile GLUCOPURE WET is a mild surfactant with a good cleaning an wetting ability.When used as a surfactant it is especially suitable bath cleaners with a mild pH value of 3-6 and all purpose cleaners. GLUCOPURE WET is mild to hard surfaces like plastics or metals common in households and typically does not create corrosion or stress cracking.In addition GLUCOPURE WET is an excellent non-EO solubilizer for hydrophobic oils and perfumes. Mildness Glucopure® surfactants are amongst the mildest surfactants in the market. They are extremely mild to both skin proteins and skin lipids and are therefore very useful for formulations with mildness claims and for sensitive skin and hair. Compatibility GLUCOPURE WET is miscible with all types of surfactants (anionic, non-ionic, cationic and amphoteric), complexing agents and other typical ingredients of hard surface cleaners.Glucopure are chemically stable in acidic and alkaline media in the pH range of approx. 3-10. Solublizing properties GLUCOPURE WET is an excellent non-EO solubilizer. Especially for terpenoides and preservative actives it shows better results than other non-EO solubilizers. Use Level A use level of 2.0 % - 10 % as solubilizer (1.0 to 5 % active) for cleaning applications recommended. For solubilisation significantly lower levels can be already sufficient. Formulation advice GLUCOPURE WET can be added to any step of the process. Storage and Shelf Life GLUCOPURE WET should be stored at room temperature.The shelf life is at least two years when stored in tightly closed containers at room temperature in a clear and aerated place. After this period the product should be analysed for extension of the shelf life.
Glucosamine
GLUCOSAMINE HCL, N° CAS : 66-84-2, Nom INCI : GLUCOSAMINE HCL. Nom chimique : Glucosamine hydrochloride. N° EINECS/ELINCS : 200-638-1. Ses fonctions (INCI). Antistatique : Réduit l'électricité statique en neutralisant la charge électrique sur une surface. Conditionneur capillaire : Laisse les cheveux faciles à coiffer, souples, doux et brillants et / ou confèrent volume, légèreté et brillance
Glucosamine sulfate
GLUCOSAMINE SULFATEN° CAS : 29031-19-4, Nom INCI : GLUCOSAMINE SULFATE. Nom chimique : D-glucosamine sulphate. N° EINECS/ELINCS : 249-379-6. Classification : Sulfate, Ses fonctions (INCI). Agent d'entretien de la peau : Maintient la peau en bon état
GLUCOSE
CAS Number: 50-99-7
EC Number: 200-075-1
Chemical formula: C6H12O6
Molar mass: 180.156 g/mol

Glucose is the main type of sugar in the blood and is the major source of energy for the body's cells.
Glucose comes from the foods we eat or the body can make it from other substances.
Glucose is carried to the cells through the bloodstream.
Several hormones, including insulin, control glucose levels in the blood.
Glucose is a simple sugar with the molecular formula C6H12O6.
Glucose is the most abundant monosaccharide, a subcategory of carbohydrates.
Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using energy from sunlight, where it is used to make cellulose in cell walls, the most abundant carbohydrate in the world.

Glucose can exist in both a straight-chain and ring form.
Glucose open-chain form of glucose makes up less than 0.02% of the glucose molecules in an aqueous solution.
Glucose rest is one of two cyclic hemiacetal forms.
In its open-chain form, the glucose molecule has an open (as opposed to cyclic) unbranched backbone of six carbon atoms, where C-1 is part of an aldehyde group (C=O)−.
Therefore, glucose is also classified as an aldose, or an aldohexose.
The aldehyde group makes glucose a reducing sugar giving a positive reaction with the Fehling test.

Glucose metabolism and various forms of it in the process
Glucose-containing compounds and isomeric forms are digested and taken up by the body in the intestines, including starch, glycogen, disaccharides and monosaccharides.
Glucose is stored in mainly the liver and muscles as glycogen.
Glucose is distributed and used in tissues as free glucose.
Main articles: Glycolysis and Pentose phosphate pathway
In humans, glucose is metabolised by glycolysis and the pentose phosphate pathway.

Glycolysis is used by all living organisms,: 551 with small variations, and all organisms generate energy from the breakdown of monosaccharides.
Glucose the further course of the metabolism, it can be completely degraded via oxidative decarboxylation, the citric acid cycle (synonym Krebs cycle) and the respiratory chain to water and carbon dioxide.
Glucose there is not enough oxygen available for this, the glucose degradation in animals occurs anaerobic to lactate via lactic acid fermentation and releases less energy.
Muscular lactate enters the liver through the bloodstream in mammals, where gluconeogenesis occurs (Cori cycle).
With a high supply of glucose, the metabolite acetyl-CoA from the Krebs cycle can also be used for fatty acid synthesis.
Glucose is also used to replenish the body's glycogen stores, which are mainly found in liver and skeletal muscle. These processes are hormonally regulated.

In energy metabolism, glucose is the most important source of energy in all organisms.
Glucose for metabolism is stored as a polymer, in plants mainly as starch and amylopectin, and in animals as glycogen.
Glucose circulates in the blood of animals as blood sugar.
The naturally occurring form of glucose is d-glucose, while l-glucose is produced synthetically in comparatively small amounts and is of lesser importance[citation needed].

Glucose is a monosaccharide containing six carbon atoms and an aldehyde group, and is therefore an aldohexose.
The glucose molecule can exist in an open-chain (acyclic) as well as ring (cyclic) form.
Glucose is naturally occurring and is found in its free state in fruits and other parts of plants.
Glucose animals, glucose is released from the breakdown of glycogen in a process known as glycogenolysis.

Glucose, as intravenous sugar solution, is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.
Glucose is also on the list in combination with sodium chloride.

Glucose is produced by plants through the photosynthesis using sunlight, water and carbon dioxide and can be used by all living organisms as an energy and carbon source.
However, most glucose does not occur in its free form, but in the form of its polymers, i.e. lactose, sucrose, starch and others which are energy reserve substances, and cellulose and chitin, which are components of the cell wall in plants or fungi and arthropods, respectively.
These polymers, when consumed by animals, fungi and bacteria, are degraded to glucose using enzymes.
All animals are also able to produce glucose themselves from certain precursors as the need arises.
Neurons, cells of the renal medulla and erythrocytes depend on glucose for their energy production.
In adult humans, there are about 18 g of glucose, of which about 4 g are present in the blood.
Approximately 180 to 220 g of glucose are produced in the liver of an adult in 24 hours.
Many of the long-term complications of diabetes (e.g., blindness, kidney failure, and peripheral neuropathy) are probably due to the glycation of proteins or lipids. In contrast, enzyme-regulated addition of sugars to protein is called glycosylation and is essential for the function of many proteins.

Uptake
Ingested glucose initially binds to the receptor for sweet taste on the tongue in humans.
Glucose complex of the proteins T1R2 and T1R3 makes it possible to identify glucose-containing food sources.
Glucose mainly comes from food—about 300 g per day are produced by conversion of food,but it is also synthesized from other metabolites in the body's cells.
In humans, the breakdown of glucose-containing polysaccharides happens in part already during chewing by means of amylase, which is contained in saliva, as well as by maltase, lactase, and sucrase on the brush border of the small intestine.
Glucose is a building block of many carbohydrates and can be split off from them using certain enzymes.
Glucosidases, a subgroup of the glycosidases, first catalyze the hydrolysis of long-chain glucose-containing polysaccharides, removing terminal glucose.

In turn, disaccharides are mostly degraded by specific glycosidases to glucose.
Glucose names of the degrading enzymes are often derived from the particular poly- and disaccharide; inter alia, for the degradation of polysaccharide chains there are amylases (named after amylose, a component of starch), cellulases (named after cellulose), chitinases (named after chitin), and more.
Furthermore, for the cleavage of disaccharides, there are maltase, lactase, sucrase, trehalase, and others. In humans, about 70 genes are known that code for glycosidases.
They have functions in the digestion and degradation of glycogen, sphingolipids, mucopolysaccharides, and poly(ADP-ribose).
Humans do not produce cellulases, chitinases, or trehalases, but the bacteria in the gut flora do.

Glucoseorder to get into or out of cell membranes of cells and membranes of cell compartments, glucose requires special transport proteins from the major facilitator superfamily.
Glucose the small intestine (more precisely, in the jejunum),glucose is taken up into the intestinal epithelium with the help of glucose transporters via a secondary active transport mechanism called sodium ion-glucose symport via sodium/glucose cotransporter 1 (SGLT1).
Further transfer occurs on the basolateral side of the intestinal epithelial cells via the glucose transporter GLUT2,as well uptake into liver cells, kidney cells, cells of the islets of Langerhans, neurons, astrocytes, and tanycytes.
Glucose enters the liver via the portal vein and is stored there as a cellular glycogen.

Glucose the liver cell, it is phosphorylated by glucokinase at position 6 to form glucose 6-phosphate, which cannot leave the cell.
Glucose 6-phosphatase can convert glucose 6-phosphate back into glucose exclusively in the liver, so the body can maintain a sufficient blood glucose concentration.
Glucose other cells, uptake happens by passive transport through one of the 14 GLUT proteins.
Glucose the other cell types, phosphorylation occurs through a hexokinase, whereupon glucose can no longer diffuse out of the cell.

The glucose transporter GLUT1 is produced by most cell types and is of particular importance for nerve cells and pancreatic β-cells. GLUT3 is highly expressed in nerve cells.
Glucose from the bloodstream is taken up by GLUT4 from muscle cells (of the skeletal muscle and heart muscle) and fat cells.GLUT14 is expressed exclusively in testicles.
Excess glucose is broken down and converted into fatty acids, which are stored as triglycerides.
Glucose the kidneys, glucose in the urine is absorbed via SGLT1 and SGLT2 in the apical cell membranes and transmitted via GLUT2 in the basolateral cell membranes.
About 90% of kidney glucose reabsorption is via SGLT2 and about 3% via SGLT1.

Biosynthesis
Main articles: Gluconeogenesis and Glycogenolysis
In plants and some prokaryotes, glucose is a product of photosynthesis.
Glucose is also formed by the breakdown of polymeric forms of glucose like glycogen (in animals and mushrooms) or starch (in plants).
The cleavage of glycogen is termed glycogenolysis, the cleavage of starch is called starch degradation.

Glucose metabolic pathway that begins with molecules containing two to four carbon atoms (C) and ends in the glucose molecule containing six carbon atoms is called gluconeogenesis and occurs in all living organisms.
The smaller starting materials are the result of other metabolic pathways.
Ultimately almost all biomolecules come from the assimilation of carbon dioxide in plants during photosynthesis:
The free energy of formation of α-d-glucose is 917.2 kilojoules per mole: 59 In humans, gluconeogenesis occurs in the liver and kidney,but also in other cell types.
Glucose the liver about 150 g of glycogen are stored, in skeletal muscle about 250 g.

However, the glucose released in muscle cells upon cleavage of the glycogen can not be delivered to the circulation because glucose is phosphorylated by the hexokinase, and a glucose-6-phosphatase is not expressed to remove the phosphate group.
Unlike for glucose, there is no transport protein for glucose-6-phosphate.
Gluconeogenesis allows the organism to build up glucose from other metabolites, including lactate or certain amino acids, while consuming energy.
The renal tubular cells can also produce glucose.

Glucose also can be found outside of living organisms in the ambient environment.
Glucose concentrations in the atmosphere are detected via collection of samples by aircraft and are known to vary from location to location.
For example, glucose concentrations in atmospheric air from inland China range from 0.8-20.1 pg/l, whereas east coastal China glucose concentrations range from 10.3-142 pg/l.

Glucose degradation
Glucose other living organisms, other forms of fermentation can occur.
The bacterium Escherichia coli can grow on nutrient media containing glucose as the sole carbon source: 
Glucose some bacteria and, in modified form, also in archaea, glucose is degraded via the Entner-Doudoroff pathway.

Use of glucose as an energy source in cells is by either aerobic respiration, anaerobic respiration, or fermentation.
Glucose first step of glycolysis is the phosphorylation of glucose by a hexokinase to form glucose 6-phosphate.
Glucose main reason for the immediate phosphorylation of glucose is to prevent its diffusion out of the cell as the charged phosphate group prevents glucose 6-phosphate from easily crossing the cell membrane.
Furthermore, addition of the high-energy phosphate group activates glucose for subsequent breakdown in later steps of glycolysis.
At physiological conditions, this initial reaction is irreversible.

In anaerobic respiration, one glucose molecule produces a net gain of two ATP molecules (four ATP molecules are produced during glycolysis through substrate-level phosphorylation, but two are required by enzymes used during the process).
In aerobic respiration, a molecule of glucose is much more profitable in that a maximum net production of 30 or 32 ATP molecules (depending on the organism) through oxidative phosphorylation is generated.

Click on genes, proteins and metabolites below to link to respective articles.

Tumor cells often grow comparatively quickly and consume an above-average amount of glucose by glycolysis,which leads to the formation of lactate, the end product of fermentation in mammals, even in the presence of oxygen.
Glucose effect is called the Warburg effect. For the increased uptake of glucose in tumors various SGLT and GLUT are overly produced.

In yeast, ethanol is fermented at high glucose concentrations, even in the presence of oxygen (which normally leads to respiration but not to fermentation).
Glucose effect is called the Crabtree effect.

Glucose can also degrade to form carbon dioxide through abiotic means.
This has been demonstrated to occur experimentally via oxidation and hydrolysis at 22˚C and a pH of 2.5.

Energy source
Diagram showing the possible intermediates in glucose degradation; Metabolic pathways orange: glycolysis, green: Entner-Doudoroff pathway, phosphorylating, yellow: Entner-Doudoroff pathway, non-phosphorylating
Glucose is a ubiquitous fuel in biology.
Glucose is used as an energy source in organisms, from bacteria to humans, through either aerobic respiration, anaerobic respiration (in bacteria), or fermentation.
Glucose is the human body's key source of energy, through aerobic respiration, providing about 3.75 kilocalories (16 kilojoules) of food energy per gram.
Breakdown of carbohydrates (e.g., starch) yields mono- and disaccharides, most of which is glucose.
Through glycolysis and later in the reactions of the citric acid cycle and oxidative phosphorylation, glucose is oxidized to eventually form carbon dioxide and water, yielding energy mostly in the form of ATP.
Glucose insulin reaction, and other mechanisms, regulate the concentration of glucose in the blood.

Glucose physiological caloric value of glucose, depending on the source, is 16.2 kilojoules per gram and 15.7 kJ/g (3.74 kcal/g), respectively.
Glucose high availability of carbohydrates from plant biomass has led to a variety of methods during evolution, especially in microorganisms, to utilize the energy and carbon storage glucose.
Differences exist in which end product can no longer be used for energy production.
The presence of individual genes, and their gene products, the enzymes, determine which reactions are possible.
The metabolic pathway of glycolysis is used by almost all living beings.
An essential difference in the use of glycolysis is the recovery of NADPH as a reductant for anabolism that would otherwise have to be generated indirectly.

Glucose and oxygen supply almost all the energy for the brain, so its availability influences psychological processes.
When glucose is low, psychological processes requiring mental effort (e.g., self-control, effortful decision-making) are impaired.
In the brain, which is dependent on glucose and oxygen as the major source of energy, the glucose concentration is usually 4 to 6 mM (5 mM equals 90 mg/dL),[40] but decreases to 2 to 3 mM when fasting.
Confusion occurs below 1 mM and coma at lower levels.
The glucose in the blood is called blood sugar.
Blood sugar levels are regulated by glucose-binding nerve cells in the hypothalamus.
In addition, glucose in the brain binds to glucose receptors of the reward system in the nucleus accumbens.
The binding of glucose to the sweet receptor on the tongue induces a release of various hormones of energy metabolism, either through glucose or through other sugars, leading to an increased cellular uptake and lower blood sugar levels.
Artificial sweeteners do not lower blood sugar levels.

The blood sugar content of a healthy person in the short-time fasting state, e.g. after overnight fasting, is about 70 to 100 mg/dL of blood (4 to 5.5 mM).
In blood plasma, the measured values are about 10–15% higher.
In addition, the values in the arterial blood are higher than the concentrations in the venous blood since glucose is absorbed into the tissue during the passage of Glucose capillary bed.
Also in the capillary blood, which is often used for blood sugar determination, the values are sometimes higher than in the venous blood. The glucose content of the blood is regulated by the hormones insulin, incretin and glucagon.
Insulin lowers the glucose level, glucagon increases it.

Furthermore, the hormones adrenaline, thyroxine, glucocorticoids, somatotropin and adrenocorticotropin lead to an increase in the glucose level.
Glucose is also a hormone-independent regulation, which is referred to as glucose autoregulation.
After food intake the blood sugar concentration increases. Values over 180 mg/dL in venous whole blood are pathological and are termed hyperglycemia, values below 40 mg/dL are termed hypoglycaemia.
When needed, glucose is released into the bloodstream by glucose-6-phosphatase from glucose-6-phosphate originating from liver and kidney glycogen, thereby regulating the homeostasis of blood glucose concentration.
In ruminants, the blood glucose concentration is lower (60 mg/dL in cattle and 40 mg/dL in sheep), because the carbohydrates are converted more by their gut flora into short-chain fatty acids.

Some glucose is converted to lactic acid by astrocytes, which is then utilized as an energy source by brain cells; some glucose is used by intestinal cells and red blood cells, while the rest reaches the liver, adipose tissue and muscle cells, where it is absorbed and stored as glycogen (under the influence of insulin).
Liver cell glycogen can be converted to glucose and returned to the blood when insulin is low or absent; muscle cell glycogen is not returned to the blood because of a lack of enzymes.
Glucose fat cells, glucose is used to power reactions that synthesize some fat types and have other purposes.
Glycogen is the body's "glucose energy storage" mechanism, because it is much more "space efficient" and less reactive than glucose itself.

As a result of its importance in human health, glucose is an analyte in glucose tests that are common medical blood tests.
Eating or fasting prior to taking a blood sample has an effect on analyses for glucose in the blood; a high fasting glucose blood sugar level may be a sign of prediabetes or diabetes mellitus.

The glycemic index is an indicator of the speed of resorption and conversion to blood glucose levels from ingested carbohydrates, measured as the area under the curve of blood glucose levels after consumption in comparison to glucose (glucose is defined as 100).
Glucose clinical importance of the glycemic index is controversial, as foods with high fat contents slow the resorption of carbohydrates and lower the glycemic index, e.g. ice cream.
An alternative indicator is the insulin index, measured as the impact of carbohydrate consumption on the blood insulin levels.
The glycemic load is an indicator for the amount of glucose added to blood glucose levels after consumption, based on the glycemic index and the amount of consumed food.

Precursor
Organisms use glucose as a precursor for the synthesis of several important substances.
Starch, cellulose, and glycogen ("animal starch") are common glucose polymers (polysaccharides).
Some of these polymers (starch or glycogen) serve as energy stores, while others (cellulose and chitin, which is made from a derivative of glucose) have structural roles.
Oligosaccharides of glucose combined with other sugars serve as important energy stores.

These include lactose, the predominant sugar in milk, which is a glucose-galactose disaccharide, and sucrose, another disaccharide which is composed of glucose and fructose.
Glucose is also added onto certain proteins and lipids in a process called glycosylation.
Glucose is often critical for their functioning.
The enzymes that join glucose to other molecules usually use phosphorylated glucose to power the formation of the new bond by coupling it with the breaking of the glucose-phosphate bond.

Other than its direct use as a monomer, glucose can be broken down to synthesize a wide variety of other biomolecules.
This is important, as glucose serves both as a primary store of energy and as a source of organic carbon.
Glucose can be broken down and converted into lipids.
Glucose is also a precursor for the synthesis of other important molecules such as vitamin C (ascorbic acid).
Glucose living organisms, glucose is converted to several other chemical compounds that are the starting material for various metabolic pathways.

Among them, all other monosaccharides such as fructose (via the polyol pathway),mannose (the epimer of glucose at position 2), galactose (the epimer at position 4), fucose, various uronic acids and the amino sugars are produced from glucose.
In addition to the phosphorylation to glucose-6-phosphate, which is part of the glycolysis, glucose can be oxidized during its degradation to glucono-1,5-lactone. Glucose is used in some bacteria as a building block in the trehalose or the dextran biosynthesis and in animals as a building block of glycogen.
Glucose can also be converted from bacterial xylose isomerase to fructose.
In addition, glucose metabolites produce all nonessential amino acids, sugar alcohols such as mannitol and sorbitol, fatty acids, cholesterol and nucleic acids.
Finally, glucose is used as a building block in the glycosylation of proteins to glycoproteins, glycolipids, peptidoglycans, glycosides and other substances (catalyzed by glycosyltransferases) and can be cleaved from them by glycosidases.

Pathology
Diabetes
Diabetes is a metabolic disorder where the body is unable to regulate levels of glucose in the blood either because of a lack of insulin in the body or the failure, by cells in the body, to respond properly to insulin.
Each of these situations can be caused by persistently high elevations of blood glucose levels, through pancreatic burnout and insulin resistance.
Glucose pancreas is the organ responsible for the secretion of the hormones insulin and glucagon.
Insulin is a hormone that regulates glucose levels, allowing the body's cells to absorb and use glucose.

Without it, glucose cannot enter the cell and therefore cannot be used as fuel for the body's functions.
Glucose the pancreas is exposed to persistently high elevations of blood glucose levels, the insulin-producing cells in the pancreas could be damaged, causing a lack of insulin in the body.
Insulin resistance occurs when the pancreas tries to produce more and more insulin in response to persistently elevated blood glucose levels.
Eventually, the rest of the body becomes resistant to the insulin that the pancreas is producing, thereby requiring more insulin to achieve the same blood glucose-lowering effect, and forcing the pancreas to produce even more insulin to compete with the resistance.
This negative spiral contributes to pancreatic burnout, and the disease progression of diabetes.

To monitor the body's response to blood glucose-lowering therapy, glucose levels can be measured.
Blood glucose monitoring can be performed by multiple methods, such as the fasting glucose test which measures the level of glucose in the blood after 8 hours of fasting.
Another test is the 2-hour glucose tolerance test (GTT) – for this test, the person has a fasting glucose test done, then drinks a 75-gram glucose drink and is retested.
This test measures the ability of the person's body to process glucose.
Over time the blood glucose levels should decrease as insulin allows it to be taken up by cells and exit the blood stream.

Hypoglycemia management

Glucose, 5% solution for infusions
Individuals with diabetes or other conditions that result in low blood sugar often carry small amounts of sugar in various forms.
One sugar commonly used is glucose, often in the form of glucose tablets (glucose pressed into a tablet shape sometimes with one or more other ingredients as a binder), hard candy, or sugar packet.

Sources

Glucose tablets
Most dietary carbohydrates contain glucose, either as their only building block (as in the polysaccharides starch and glycogen), or together with another monosaccharide (as in the hetero-polysaccharides sucrose and lactose).
Unbounded glucose is one of the main ingredients of honey.
Glucose is extremely abundant and has been isolated from a variety of natural sources across the world, including male cones of the coniferous tree Wollemia nobilis in Rome, the roots of Ilex asprella plants in China, and straws from rice in California.

Commercial production
Glucose is produced industrially from starch by enzymatic hydrolysis using glucose amylase or by the use of acids.
Glucose enzymatic hydrolysis has largely displaced the acid-catalyzed hydrolysis.
Glucose result is glucose syrup (enzymatically with more than 90% glucose in the dry matter) with an annual worldwide production volume of 20 million tonnes (as of 2011).
This is the reason for the former common name "starch sugar".

The amylases most often come from Bacillus licheniformis or Bacillus subtilis (strain MN-385), which are more thermostable than the originally used enzymes.
Starting in 1982, pullulanases from Aspergillus niger were used in the production of glucose syrup to convert amylopectin to starch (amylose), thereby increasing the yield of glucose.
Glucose reaction is carried out at a pH = 4.6–5.2 and a temperature of 55–60 °C.
Corn syrup has between 20% and 95% glucose in the dry matter.
The Japanese form of the glucose syrup, Mizuame, is made from sweet potato or rice starch.
Maltodextrin contains about 20% glucose.

Many crops can be used as the source of starch.
Maize,rice,wheat,cassava,potato, barley, sweet potato,corn husk and sago are all used in various parts of the world.
In the United States, corn starch (from maize) is used almost exclusively.
Some commercial glucose occurs as a component of invert sugar, a roughly 1:1 mixture of glucose and fructose that is produced from sucrose.
In principle, cellulose could be hydrolysed to glucose, but this process is not yet commercially practical.

Conversion to fructose
Main article: isoglucose
In the USA almost exclusively corn (more precisely: corn syrup) is used as glucose source for the production of isoglucose, which is a mixture of glucose and fructose, since fructose has a higher sweetening power — with same physiological calorific value of 374 kilocalories per 100 g.
The annual world production of isoglucose is 8 million tonnes (as of 2011).
When made from corn syrup, the final product is high fructose corn syrup (HFCS).

Commercial usage
Relative sweetness of various sugars in comparison with sucrose
Glucose is mainly used for the production of fructose and in the production of glucose-containing foods.
Glucose foods, it is used as a sweetener, humectant, to increase the volume and to create a softer mouthfeel.
Various sources of glucose, such as grape juice (for wine) or malt (for beer), are used for fermentation to ethanol during the production of alcoholic beverages.

Most soft drinks in the US use HFCS-55 (with a fructose content of 55% in the dry mass), while most other HFCS-sweetened foods in the US use HFCS-42 (with a fructose content of 42% in the dry mass).
Glucose the neighboring country Mexico, on the other hand, cane sugar is used in the soft drink as a sweetener, which has a higher sweetening power.
In addition, glucose syrup is used, inter alia, in the production of confectionery such as candies, toffee and fondant.
Typical chemical reactions of glucose when heated under water-free conditions are the caramelization and, in presence of amino acids, the maillard reaction.

In addition, various organic acids can be biotechnologically produced from glucose, for example by fermentation with Clostridium thermoaceticum to produce acetic acid, with Penicillium notatum for the production of araboascorbic acid, with Rhizopus delemar for the production of fumaric acid, with Aspergillus niger for the production of gluconic acid, with Candida brumptii to produce isocitric acid, with Aspergillus terreus for the production of itaconic acid, with Pseudomonas fluorescens for the production of 2-ketogluconic acid, with Gluconobacter suboxydans for the production of 5-ketogluconic acid, with Aspergillus oryzae for the production of kojic acid, with Lactobacillus delbrueckii for the production of lactic acid, with Lactobacillus brevis for the production of malic acid, with Propionibacter shermanii for the production of propionic acid, with Pseudomonas aeruginosa for the production of pyruvic acid and with Gluconobacter suboxydans for the production of tartaric acid Potent, bioactive natural products like triptolide that inhibit mammalian transcription via inhibition of the XPB subunit of the general transcription factor TFIIH has been recently reported as a glucose conjugate for targeting hypoxic cancer cells with increased glucose transporter expression.
Recently, glucose has been gaining commercial use as a key component of "kits" containing lactic acid and insulin intended to induce hypoglycemia and hyperlactatemia to combat different cancers and infections.

Analysis
Specifically, when a glucose molecule is to be detected at a certain position in a larger molecule, nuclear magnetic resonance spectroscopy, X-ray crystallography analysis or lectin immunostaining is performed with concanavalin A reporter enzyme conjugate (that binds only glucose or mannose).

Classical qualitative detection reactions
These reactions have only historical significance:

Fehling test
Glucose Fehling test is a classic method for the detection of aldoses.
Due to mutarotation, glucose is always present to a small extent as an open-chain aldehyde.
By adding the Fehling reagents (Fehling (I) solution and Fehling (II) solution), the aldehyde group is oxidized to a carboxylic acid, while the Cu2+ tartrate complex is reduced to Cu+ and forms a brick red precipitate (Cu2O).

Tollens test
Glucose the Tollens test, after addition of ammoniacal AgNO3 to the sample solution, Ag+ is reduced by glucose to elemental silver.

Barfoed test
Glucose Barfoed's test, a solution of dissolved copper acetate, sodium acetate and acetic acid is added to the solution of the sugar to be tested and subsequently heated in a water bath for a few minutes.
Glucose and other monosaccharides rapidly produce a reddish color and reddish brown copper(I) oxide (Cu2O).

Nylander's test
As a reducing sugar, glucose reacts in the Nylander's test.

Other tests
Upon heating a dilute potassium hydroxide solution with glucose to 100 °C, a strong reddish browning and a caramel-like odor develops.
Concentrated sulfuric acid dissolves dry glucose without blackening at room temperature forming sugar sulfuric acid.
Glucose a yeast solution, alcoholic fermentation produces carbon dioxide in the ratio of 2.0454 molecules of glucose to one molecule of CO2.
Glucose forms a black mass with stannous chloride.
Glucose an ammoniacal silver solution, glucose (as well as lactose and dextrin) leads to the deposition of silver.
Glucose an ammoniacal lead acetate solution, white lead glycoside is formed in the presence of glucose, which becomes less soluble on cooking and turns brown.
Glucose an ammoniacal copper solution, yellow copper oxide hydrate is formed with glucose at room temperature, while red copper oxide is formed during boiling (same with dextrin, except for with an ammoniacal copper acetate solution).
With Hager's reagent, glucose forms mercury oxide during boiling.
An alkaline bismuth solution is used to precipitate elemental, black-brown bismuth with glucose.
Glucose boiled in an ammonium molybdate solution turns the solution blue.
A solution with indigo carmine and sodium carbonate destains when boiled with glucose.

Instrumental quantification
Refractometry and polarimetry
In concentrated solutions of glucose with a low proportion of other carbohydrates, its concentration can be determined with a polarimeter.
For sugar mixtures, the concentration can be determined with a refractometer, for example in the Oechsle determination in the course of the production of wine.

Photometric enzymatic methods in solution
Main article: Glucose oxidation reaction
The enzyme glucose oxidase (GOx) converts glucose into gluconic acid and hydrogen peroxide while consuming oxygen.
Another enzyme, peroxidase, catalyzes a chromogenic reaction (Trinder reaction) of phenol with 4-aminoantipyrine to a purple dye.

Photometric test-strip method
Glucose test-strip method employs the above-mentioned enzymatic conversion of glucose to gluconic acid to form hydrogen peroxide.
Glucose reagents are immobilised on a polymer matrix, the so-called test strip, which assumes a more or less intense color.
This can be measured reflectometrically at 510 nm with the aid of an LED-based handheld photometer.
Glucose allows routine blood sugar determination by laymen.
In addition to the reaction of phenol with 4-aminoantipyrine, new chromogenic reactions have been developed that allow photometry at higher wavelengths (550 nm, 750 nm).
Amperometric glucose sensor

Glucose electroanalysis of glucose is also based on the enzymatic reaction mentioned above.
Glucose produced hydrogen peroxide can be amperometrically quantified by anodic oxidation at a potential of 600 mV.
Glucose GOx is immobilised on the electrode surface or in a membrane placed close to the electrode.
Precious metals such as platinum or gold are used in electrodes, as well as carbon nanotube electrodes, which e.g. are doped with boron.
Cu–CuO nanowires are also used as enzyme-free amperometric electrodes.
This way a detection limit of 50 µmol/L has been achieved.
A particularly promising method is the so-called "enzyme wiring".
In this case, the electron flowing during the oxidation is transferred directly from the enzyme via a molecular wire to the electrode.

Other sensory methods
There are a variety of other chemical sensors for measuring glucose.
Given the importance of glucose analysis in the life sciences, numerous optical probes have also been developed for saccharides based on the use of boronic acids, which are particularly useful for intracellular sensory applications where other (optical) methods are not or only conditionally usable.
In addition to the organic boronic acid derivatives, which often bind highly specifically to the 1,2-diol groups of sugars, there are also other probe concepts classified by functional mechanisms which use selective glucose-binding proteins (e.g. concanavalin A) as a receptor.
Furthermore, methods were developed which indirectly detect the glucose concentration via the concentration of metabolised products, e.g. by the consumption of oxygen using fluorescence-optical sensors.
Finally, there are enzyme-based concepts that use the intrinsic absorbance or fluorescence of (fluorescence-labeled) enzymes as reporters.
Copper iodometry
Glucose can be quantified by copper iodometry.

Chromatographic methods
Glucose particular, for the analysis of complex mixtures containing glucose, e.g. in honey, chromatographic methods such as high performance liquid chromatography and gas chromatography are often used in combination with mass spectrometry.
Taking into account the isotope ratios, it is also possible to reliably detect honey adulteration by added sugars with these methods.
Derivatisation using silylation reagents is commonly used.
Also, the proportions of di- and trisaccharides can be quantified.

Glucose vivo analysis
Glucose uptake in cells of organisms is measured with 2-deoxy-D-glucose or fluorodeoxyglucose.
(18F)fluorodeoxyglucose is used as a tracer in positron emission tomography in oncology and neurology,where it is by far the most commonly used diagnostic agent.

So what is glucose, exactly?
Glucose the simplest of the carbohydrates, making it a monosaccharide.
Glucose means it has one sugar.
Glucose not alone.
Other monosaccharides include fructose, galactose, and ribose.

Along with fat, glucose is one of the body’s preferred sources of fuel in the form of carbohydrates.
People get glucose from bread, fruits, vegetables, and dairy products.
You need food to create the energy that helps keep you alive.

While glucose is important, like with so many things, it’s best in moderation.
Glucose levels that are unhealthy or out of control can have permanent and serious effects.

How does the body process glucose?
Our body processes glucose multiple times a day, ideally.

When we eat, our body immediately starts working to process glucose.
Enzymes start the breakdown process with help from the pancreas.
Glucose pancreas, which produces hormones including insulin, is an integral part of how our body deals with glucose.
When we eat, our body tips the pancreas off that it needs to release insulin to deal with the rising blood sugar level.

Identifiers
CAS Number:50-99-7
492-62-6 (α-d-glucopyranose)
3DMet:B01203
Abbreviations: Glc
Beilstein Reference: 1281604
ChEBI: CHEBI:4167
ChEMBL:ChEMBL1222250
ChemSpider:5589
EC Number:200-075-1
Gmelin Reference: 83256
IUPHAR/BPS:4536
KEGG:C00031
MeSH: Glucose
PubChem CID:5793
RTECS number:LZ6600000
UNII :
5SL0G7R0OK
5J5I9EB41E (α-d-glucopyranose)

Properties
Chemical formula: C6H12O6
Molar mass: 180.156 g/mol
Appearance: White powder
Density :1.54 g/cm3
Melting point: α-d-Glucose: 146 °C (295 °F; 419 K)
β-d-Glucose: 150 °C (302 °F; 423 K)
Solubility in water: 909 g/L (25 °C (77 °F))
Magnetic susceptibility (χ): −101.5×10−6 cm3/mol
Dipole moment: 8.6827

Thermochemistry
Heat capacity (C): 218.6 J/(K·mol)[1]
Std molar entropy :(So298) 209.2 J/(K·mol)[1]
Std enthalpy of formation (ΔfH⦵298): −1271 kJ/mol[2]
Heat of combustion, higher value (HHV): 2,805 kJ/mol (670 kcal/mol)

Pharmacology
ATC code: B05CX01 (WHO) V04CA02 (WHO), V06DC01 (WHO)

glucose, also called dextrose, one of a group of carbohydrates known as simple sugars (monosaccharides).
Glucose (from Greek glykys; “sweet”) has the molecular formula C6H12O6.
Glucose is found in fruits and honey and is the major free sugar circulating in the blood of higher animals.
Glucose is the source of energy in cell function, and the regulation of its metabolism is of great importance (see fermentation; gluconeogenesis).
Molecules of starch, the major energy-reserve carbohydrate of plants, consist of thousands of linear glucose units.
Another major compound composed of glucose is cellulose, which is also linear.
Dextrose is the molecule D-glucose.
A related molecule in animals is glycogen, the reserve carbohydrate in most vertebrate and invertebrate animal cells, as well as those of numerous fungi and protozoans.
See also polysaccharide.

What is glucose?
You may know glucose by another name: blood sugar.
Glucose is key to keeping the mechanisms of the body in top working order.
When our glucose levels are optimal, it often goes unnoticed.
But when they stray from recommended boundaries, you’ll notice the unhealthy effect it has on normal functioning.

Some people, however, can’t rely on their pancreas to jump in and do the work it’s supposed to do.

One way diabetes occurs is when the pancreas doesn’t produce insulin in the way it should.
Glucose this case, people need outside help (insulin injections) to process and regulate glucose in the body.
Another cause of diabetes is insulin resistance, where the liver doesn’t recognize insulin that’s in the body and continues to make inappropriate amounts of glucose.
The liver is an important organ for sugar control, as it helps with glucose storage and makes glucose when necessary.

Glucose the body doesn’t produce enough insulin, it can result in the release of free fatty acids from fat stores.
This can lead to a condition called ketoacidosis.
Ketones, waste products created when the liver breaks down fat, can be toxic in large quantities.

How do you test your glucose?
Testing glucose levels is especially important for people with diabetes.
Most people with the condition are used to dealing with blood sugar checks as part of their daily routine.

One of the most common ways to test glucose at home involves a very simple blood test.
A finger prick, usually using a small needle called a lancet, produces a drop that is put onto a test strip.
The strip is put into a meter, which measures blood sugar levels.
Glucose can usually give you a reading in under 20 seconds.

What Is Glucose?
By Stephanie Watson
Medically Reviewed by Carol DerSarkissian, MD on June 13, 2020
IN THIS ARTICLE
How Your Body Makes Glucose
Energy and Storage
Blood Glucose Levels and Diabetes
Glucose comes from the Greek word for "sweet."
It's a type of sugar you get from foods you eat, and your body uses it for energy.
As it travels through your bloodstream to your cells, it's called blood glucose or blood sugar.

Insulin is a hormone that moves glucose from your blood into the cells for energy and storage.
People with diabetes have higher-than-normal levels of glucose in their blood.
Either they don't have enough insulin to move it through or their cells don't respond to insulin as well as they should.

High blood glucose for a long period of time can damage your kidneys, eyes, and other organs.

How Your Body Makes Glucose
Glucose mainly comes from foods rich in carbohydrates, like bread, potatoes, and fruit.
As you eat, food travels down your esophagus to your stomach. There, acids and enzymes break it down into tiny pieces.
During that process, glucose is released.

Glucose goes into your intestines where it's absorbed. From there, it passes into your bloodstream.
Once in the blood, insulin helps glucose get to your cells.


Energy and Storage
Your body is designed to keep the level of glucose in your blood constant.
Beta cells in your pancreas monitor your blood sugar level every few seconds.
When your blood glucose rises after you eat, the beta cells release insulin into your bloodstream.
Insulin acts like a key, unlocking muscle, fat, and liver cells so glucose can get inside them.

Most of the cells in your body use glucose along with amino acids (the building blocks of protein) and fats for energy.
But it's the main source of fuel for your brain.
Nerve cells and chemical messengers there need it to help them process information.
Without it, your brain wouldn't be able to work well.

After your body has used the energy it needs, the leftover glucose is stored in little bundles called glycogen in the liver and muscles.
Your body can store enough to fuel you for about a day.

After you haven't eaten for a few hours, your blood glucose level drops.
Your pancreas stops churning out insulin. Alpha cells in the pancreas begin to produce a different hormone called glucagon.
Glucose signals the liver to break down stored glycogen and turn it back into glucose.

That travels to your bloodstream to replenish your supply until you're able to eat again.
Your liver can also make its own glucose using a combination of waste products, amino acids, and fats.

Blood Glucose Levels and Diabetes
Your blood sugar level normally rises after you eat.
Then it dips a few hours later as insulin moves glucose into your cells.
Between meals, your blood sugar should be less than 100 milligrams per deciliter (mg/dl).
Glucose is called your fasting blood sugar level.

There are two types of diabetes:
Glucose type 1 diabetes, your body doesn't have enough insulin.
Glucose immune system attacks and destroys cells of the pancreas, where insulin is made.
Glucose type 2 diabetes, the cells don't respond to insulin like they should.
So the pancreas needs to make more and more insulin to move glucose into the cells.
Eventually, the pancreas is damaged and can't make enough insulin to meet the body's needs.
Without enough insulin, glucose can't move into the cells. The blood glucose level stays high.
A level over 200 mg/dl 2 hours after a meal or over 125 mg/dl fasting is high blood glucose, called hyperglycemia.

Too much glucose in your bloodstream for a long period of time can damage the vessels that carry oxygen-rich blood to your organs.
High blood sugar can increase your risk for:

Heart disease, heart attack, and stroke
Kidney disease
Nerve damage
Eye disease called retinopathy
People with diabetes need to test their blood sugar often. Exercise, diet, and medicine can help keep blood glucose in a healthy range and prevent these complications.

Description
Catalogue Number: 346351
Brand Family: Calbiochem®
Synonyms :Dextrose, α-D-Glucose
Product Information
CAS number: 50-99-7
Form :White powder
Hill Formula: C₆H₁₂O₆
Chemical formula: C₆H₁₂O₆
Quality Level: MQ100
Physicochemical :Information
Contaminants :Maltose: ≤0.2%; heavy metals: ≤0.001%
Safety :Information according to GHS
RTECS LZ6600000
Storage and Shipping Information
Ship Code: Ambient Temperature Only
Toxicity: Standard Handling
Storage +15°C to +30°C
Do not freeze :Ok to freeze
Special Instructions: Following reconstitution, filter-sterilize and store at room temperature.
Stock solutions are stable for several months at room temperature.


What is a blood glucose test?
A blood glucose test is a blood test that screens for diabetes by measuring the level of glucose (sugar) in a person’s blood.

Who is most at risk for developing diabetes?
The following categories of people are considered "high-risk" candidates for developing diabetes:

Insulin is a hormone made by the pancreas.
Glucose job is to move glucose from the bloodstream into the cells of tissues.
After you eat, the level of glucose in the blood rises sharply.
The pancreas responds by releasing enough insulin to handle the increased level of glucose — moving the glucose out of the blood and into cells.
This helps return the blood glucose level to its former, lower level.

If a person has diabetes, two situations may cause the blood sugar to increase:

The pancreas does not make enough insulin
The insulin does not work properly
As a result of either of these situations, the blood sugar level remains high, a condition called hyperglycemia or diabetes mellitus.
Glucose left undiagnosed and untreated, the eyes, kidneys, nerves, heart, blood vessels and other organs can be damaged.
Measuring your blood glucose levels allows you and your doctor to know if you have, or are at risk for, developing diabetes.

Much less commonly, the opposite can happen too.
Too low a level of blood sugar, a condition called hypoglycemia, can be caused by the presence of too much insulin or by other hormone disorders or liver disease.

How do I prepare for the plasma glucose level test and how are the results interpreted?
To get an accurate plasma glucose level, you must have fasted (not eaten or had anything to drink except water) for at least 8 hours prior to the test.
When you report to the clinic or laboratory, a small sample of blood will be taken from a vein in your arm.
According to the practice recommendations of the American Diabetes Association, the results of the blood test are interpreted as follows:

Fasting blood glucose level
If your blood glucose level is 70 to 99* mg/dL (3.9 to 5.5 mmol/L). . .
What it means: Your glucose level is within the normal range
If your blood glucose level is 100 to 125 mg/dL (5.6 to 6.9 mmol/L). . .
What it means: You have an impaired fasting glucose level (pre-diabetes**) . . .
If your blood glucose level is 126 mg/dl (7.0 mmol/L ) or higher on more than one testing occasion
What it means: You have diabetes

Glucose is a monosaccharide and is the primary metabolite for energy production in the body.
Complex carbohydrates are ultimately broken down in the digestive system into glucose and other monosaccharides, such as fructose or galactose, prior to absorption in the small intestine; of note, insulin is not required for the uptake of glucose by the intestinal cells.
Glucose is transported into the cells by an active, energy-requiring process that involves a specific transport protein and requires a concurrent uptake of sodium ions.

In the blood circulation, the concentration of glucose is tightly regulated by hormones such as insulin, cortisol, and glucagon, which regulate glucose entry into cells and affect various metabolic processes such as glycolysis, gluconeogenesis, and glycogenolysis.

Glucose belongs to the family of carbohydrates.
Glucose is a monosaccharide (simple sugar) naturally present in all living beings on Earth and is their most important source of energy.
Glucose is found in high quantities in fruit (including berries), vegetables and honey.
When combined with other monosaccharides, such as fructose, it forms sucrose (table sugar) and lactose.
Two glucose molecules form maltose, a disaccharide resulting from the hydrolysis of cereal starch.
Maltose has slightly less sweetening power than sucrose.
Athletes use it for a quick supply of energy, whereas in bakeries it is useful for the fermentation of leavened dough. Maltose is also found in the germinated cereal grains used to make many types of beer.

Starch consists of a large number of glucose molecules linked to each other in long chains.
Cellulose is a polysaccharide made up of complex chains of starch. Unlike herbivorous mammals, the human body is unable to digest cellulose, so it serves as roughage in our diet.

Glc concentrations in tissues and body fluids are stabilized by many diverse mechanisms, many of which involve the action of specific hormones.
Overall homeostasis is maintained through directing the flux of Glc to or from glycogen stores, balancing glycolysis versus gluconeogenesis, and promoting protein catabolism in times of need.

History
Glucose was first isolated from raisins in 1747 by the German chemist Andreas Marggraf.
Glucose was discovered in grapes by another German chemist – Johann Tobias Lowitz in 1792, and distinguished as being different from cane sugar (sucrose).
Glucose is the term coined by Jean Baptiste Dumas in 1838, which has prevailed in the chemical literature.
Friedrich August Kekulé proposed the term dextrose (from Latin dexter = right), because in aqueous solution of glucose, the plane of linearly polarized light is turned to the right.
In contrast, d-fructose (a ketohexose) and l-glucose turn linearly polarized light to the left.
The earlier notation according to the rotation of the plane of linearly polarized light (d and l-nomenclature) was later abandoned in favor of the d- and l-notation, which refers to the absolute configuration of the asymmetric center farthest from the carbonyl group, and in concordance with the configuration of d- or l-glyceraldehyde.

Since glucose is a basic necessity of many organisms, a correct understanding of its chemical makeup and structure contributed greatly to a general advancement in organic chemistry.
This understanding occurred largely as a result of the investigations of Emil Fischer, a German chemist who received the 1902 Nobel Prize in Chemistry for his findings.
The synthesis of glucose established the structure of organic material and consequently formed the first definitive validation of Jacobus Henricus van 't Hoff's theories of chemical kinetics and the arrangements of chemical bonds in carbon-bearing molecules.
Between 1891 and 1894, Fischer established the stereochemical configuration of all the known sugars and correctly predicted the possible isomers, applying Van 't Hoff's theory of asymmetrical carbon atoms.
The names initially referred to the natural substances. Their enantiomers were given the same name with the introduction of systematic nomenclatures, taking into account absolute stereochemistry (e.g. Fischer nomenclature, d/l nomenclature).

For the discovery of the metabolism of glucose Otto Meyerhof received the Nobel Prize in Physiology or Medicine in 1922.
Hans von Euler-Chelpin was awarded the Nobel Prize in Chemistry along with Arthur Harden in 1929 for their "research on the fermentation of sugar and their share of enzymes in this process".
In 1947, Bernardo Houssay (for his discovery of the role of the pituitary gland in the metabolism of glucose and the derived carbohydrates) as well as Carl and Gerty Cori (for their discovery of the conversion of glycogen from glucose) received the Nobel Prize in Physiology or Medicine.
In 1970, Luis Leloir was awarded the Nobel Prize in Chemistry for the discovery of glucose-derived sugar nucleotides in the biosynthesis of carbohydrates.
Chemical properties
Glucose forms white or colorless solids that are highly soluble in water and acetic acid but poorly soluble in methanol and ethanol.
Glucose melt at 146 °C (295 °F) (α) and 150 °C (302 °F) (β), and decompose starting at 188 °C (370 °F) with release of various volatile products, ultimately leaving a residue of carbon.
Glucose has a dissociation exponent (pK) of 12.16 at 25˚C in methanol and water.

With six carbon atoms, it is classed as a hexose, a subcategory of the monosaccharides. d-Glucose is one of the sixteen aldohexose stereoisomers.
Glucose d-isomer, d-glucose, also known as dextrose, occurs widely in nature, but the l-isomer, l-glucose, does not.
Glucose can be obtained by hydrolysis of carbohydrates such as milk sugar (lactose), cane sugar (sucrose), maltose, cellulose, glycogen, etc. Dextrose is commonly commercially manufactured from cornstarch in the US and Japan, from potato and wheat starch in Europe, and from tapioca starch in tropical areas.
Glucose manufacturing process uses hydrolysis via pressurized steaming at controlled pH in a jet followed by further enzymatic depolymerization.
Unbonded glucose is one of the main ingredients of honey.
All forms of glucose are colorless and easily soluble in water, acetic acid, and several other solvents.
They are only sparingly soluble in methanol and ethanol.

Structure and nomenclature

Mutarotation of glucose.
Glucose is usually present in solid form as a monohydrate with a closed pyran ring (dextrose hydrate).
Glucose aqueous solution, on the other hand, it is an open-chain to a small extent and is present predominantly as α- or β-pyranose, which interconvert (see mutarotation).
From aqueous solutions, the three known forms can be crystallized: α-glucopyranose, β-glucopyranose and β-glucopyranose hydrate.
Glucose is a building block of the disaccharides lactose and sucrose (cane or beet sugar), of oligosaccharides such as raffinose and of polysaccharides such as starch and amylopectin, glycogen or cellulose.
The glass transition temperature of glucose is 31 °C and the Gordon–Taylor constant (an experimentally determined constant for the prediction of the glass transition temperature for different mass fractions of a mixture of two substances) is 4.5.

From left to right: Haworth projections and ball-and-stick structures of the α- and β- anomers of D-glucopyranose (top row) and D-glucofuranose (bottom row)
In solutions, the open-chain form of glucose (either "D-" or "L-") exists in equilibrium with several cyclic isomers, each containing a ring of carbons closed by one oxygen atom.
In aqueous solution, however, more than 99% of glucose molecules exist as pyranose forms.
Glucose open-chain form is limited to about 0.25%, and furanose forms exist in negligible amounts.
The terms "glucose" and "D-glucose" are generally used for these cyclic forms as well.
The ring arises from the open-chain form by an intramolecular nucleophilic addition reaction between the aldehyde group (at C-1) and either the C-4 or C-5 hydroxyl group, forming a hemiacetal linkage, −C(OH)H−O−.

Glucose reaction between C-1 and C-5 yields a six-membered heterocyclic system called a pyranose, which is a monosaccharide sugar (hence "-ose") containing a derivatised pyran skeleton.
Glucose (much rarer) reaction between C-1 and C-4 yields a five-membered furanose ring, named after the cyclic ether furan.
In either case, each carbon in the ring has one hydrogen and one hydroxyl attached, except for the last carbon (C-4 or C-5) where the hydroxyl is replaced by the remainder of the open molecule (which is −(C(CH2OH)HOH)−H or −(CHOH)−H respectively).
Glucose ring-closing reaction can give two products, denoted "α-" and "β-" When a glucopyranose molecule is drawn in the Haworth projection, the designation "α-" means that the hydroxyl group attached to C-1 and the −CH2OH group at C-5 lies on opposite sides of the ring's plane (a trans arrangement), while "β-" means that they are on the same side of the plane (a cis arrangement).
Therefore, the open-chain isomer D-glucose gives rise to four distinct cyclic isomers: α-D-glucopyranose, β-D-glucopyranose, α-D-glucofuranose, and β-D-glucofuranose.
These five structures exist in equilibrium and interconvert, and the interconversion is much more rapid with acid catalysis.

Glucose other open-chain isomer L-glucose similarly gives rise to four distinct cyclic forms of L-glucose, each the mirror image of the corresponding D-glucose.

The glucopyranose ring (α or β) can assume several non-planar shapes, analogous to the "chair" and "boat" conformations of cyclohexane.
Similarly, the glucofuranose ring may assume several shapes, analogous to the "envelope" conformations of cyclopentane.

In the solid state, only the glucopyranose forms are observed.

Some derivatives of glucofuranose, such as 1,2-O-isopropylidene-d-glucofuranose are stable and can be obtained pure as crystalline solids.
For example, reaction of α-D-glucose with para-tolylboronic acid H3C−(C6H4)−B(OH)2 reforms the normal pyranose ring to yield the 4-fold ester α-D-glucofuranose-1,2∶3,5-bis(p-tolylboronate).

Mutarotation

Mutarotation: d-glucose molecules exist as cyclic hemiacetals that are epimeric (= diastereomeric) to each other.
Glucoseepimeric ratio α:β is 36:64. In the α-D-glucopyranose (left), the blue-labelled hydroxy group is in the axial position at the anomeric centre, whereas in the β-D-glucopyranose (right) the blue-labelled hydroxy group is in equatorial position at the anomeric centre.
Mutarotation consists of a temporary reversal of the ring-forming reaction, resulting in the open-chain form, followed by a reforming of the ring.
Glucose ring closure step may use a different −OH group than the one recreated by the opening step (thus switching between pyranose and furanose forms), or the new hemiacetal group created on C-1 may have the same or opposite handedness as the original one (thus switching between the α and β forms).
Thus, though the open-chain form is barely detectable in solution, it is an essential component of the equilibrium.

The open-chain form is thermodynamically unstable, and it spontaneously isomerizes to the cyclic forms.
(Although the ring closure reaction could in theory create four- or three-atom rings, these would be highly strained, and are not observed in practice.) In solutions at room temperature, the four cyclic isomers interconvert over a time scale of hours, in a process called mutarotation.
Starting from any proportions, the mixture converges to a stable ratio of α:β 36:64.
Glucose ratio would be α:β 11:89 if it were not for the influence of the anomeric effect.
Mutarotation is considerably slower at temperatures close to 0 °C (32 °F).

Optical activity
Whether in water or the solid form, d-(+)-glucose is dextrorotatory, meaning it will rotate the direction of polarized light clockwise as seen looking toward the light source. The effect is due to the chirality of the molecules, and indeed the mirror-image isomer, l-(−)-glucose, is levorotatory (rotates polarized light counterclockwise) by the same amount.
Glucose strength of the effect is different for each of the five tautomers.

Note that the d- prefix does not refer directly to the optical properties of the compound.
Glucose indicates that the C-5 chiral centre has the same handedness as that of d-glyceraldehyde (which was so labelled because it is dextrorotatory).
The fact that d-glucose is dextrorotatory is a combined effect of its four chiral centres, not just of C-5; and indeed some of the other d-aldohexoses are levorotatory.

Glucose conversion between the two anomers can be observed in a polarimeter since pure α-dglucose has a specific rotation angle of +112.2°·ml/(dm·g), pure β- D- glucose of +17.5°·ml/(dm·g).
When equilibrium has been reached after a certain time due to mutarotation, the angle of rotation is +52.7°·ml/(dm·g).
By adding acid or base, this transformation is much accelerated.
Glucose equilibration takes place via the open-chain aldehyde form.

Isomerisation
In dilute sodium hydroxide or other dilute bases, the monosaccharides mannose, glucose and fructose interconvert (via a Lobry de Bruyn–Alberda–Van Ekenstein transformation), so that a balance between these isomers is formed.
Glucose reaction proceeds via an enediol:

Biochemical properties
Metabolism of common monosaccharides and some biochemical reactions of glucose
Glucose is the most abundant monosaccharide.
Glucose is also the most widely used aldohexose in most living organisms.
One possible explanation for this is that glucose has a lower tendency than other aldohexoses to react nonspecifically with the amine groups of proteins.
Glucose reaction—glycation—impairs or destroys the function of many proteins, e.g. in glycated hemoglobin.
Glucose's low rate of glycation can be attributed to its having a more stable cyclic form compared to other aldohexoses, which means it spends less time than they do in its reactive open-chain form.
Glucose reason for glucose having the most stable cyclic form of all the aldohexoses is that its hydroxy groups (with the exception of the hydroxy group on the anomeric carbon of d-glucose) are in the equatorial position.
Presumably, glucose is the most abundant natural monosaccharide because it is less glycated with proteins than other monosaccharides.
Another hypothesis is that glucose, being the only d-aldohexose that has all five hydroxy substituents in the equatorial position in the form of β-d-glucose, is more readily accessible to chemical reactions,: 194, 199 for example, for esterification: 363 or acetal formation.
For this reason, d-glucose is also a highly preferred building block in natural polysaccharides (glycans). Polysaccharides that are composed solely of glucose are termed glucans.

D-Glc
D-Glucopyranose
D-Glucopyranoside
D-Glucose
Glc
Glucopyranose
Glucopyranoside
Glucose
2280-44-6
Grape sugar
D-Glcp
Traubenzucker
Glucose solution
(3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
CHEBI:4167
Corn sugar
a-D-Glucose
Glucopyranose, D-
DSSTox_CID_2910
Glucodin
Goldsugar
Meritose
Vadex
Clintose L
CPC hydrate
Roferose ST
D-glucose (closed ring structure, complete stereochemistry)
Clearsweet 95
Staleydex 95M
Staleydex 111
(+)-Glucose
(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Cerelose 2001
Tabfine 097(HS)
2h-pyran-2,3,4,5-tetraol
D-Glucopyranose, anhydrous
glc-ring
Cartose Cerelose
D-aGlucopyranose
D-glucose-ring
Glucose injection
Glucose 40
Staleydex 130
EINECS 218-914-5
Glc-OH
Meritose 200
nchembio867-comp4
Glucose (JP17)
6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetraol
Anhydrous Glucose ,(S)
Purified glucose (JP17)
Epitope ID:142342
D-(+)-DEXTROSE
DSSTox_RID_76784
DSSTox_RID_82925
DSSTox_GSID_22910
DSSTox_GSID_48729
GTPL4536
CHEMBL1222250
BDBM34103
DTXSID501015215
DTXSID901015217
Tox21_113165
Tox21_200145
AKOS025147374
NSC 287045
CAS-50-99-7
NCGC00166293-01
NCGC00257699-01
CAS-58367-01-4
G0048
(3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-
C00031
D00009
Q37525

Regulatory process names
Glucose
Glucose
glucose

IUPAC names
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
(3R,4S,5S)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
6-(hydroxymethyl)oxane-2,3,4,5-tetrol
D(+)-Glucose monohydrate
D-Glucose
D-glucose
Dextrose
Glucose
Grape sugar
111688-73-4
162222-91-5
165659-51-8
50-99-7
50933-92-1
5996-10-1
8012-24-6
80206-31-1
8030-23-7

D-Glc
D-Glucopyranose
D-Glucopyranoside
D-Glucose
Glc
Glucopyranose
Glucopyranoside
Glucose
2280-44-6
Grape sugar
D-Glcp
Traubenzucker
Glucose solution
(3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
Dextrose solution
CHEBI:4167
Corn sugar
Glucopyranose, D-
(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
DSSTox_CID_2910
Glucodin
Goldsugar
Meritose
54-17-1
Vadex
Clintose L
CPC hydrate
Roferose ST
Glucose Anhydrous
a-D-Glucose
Clearsweet 95
Staleydex 95M
Staleydex 111
(+)-Glucose
Cerelose 200
rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Tabfine 097(HS)
2h-pyran-2,3,4,5-tetraol
D-Glucopyranose, anhydrous
Liquid glucose
glc-ring
anhydrous glucose
Cartose Cerelose
D-aGlucopyranose
D-glucose-ring
Glucose injection
Glucose 40
Staleydex 130
EINECS 218-914-5
Glc-OH
Meritose 200
nchembio867-comp4
Dextrose, unspecified
Glucose (JP17)
starbld0000491
6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetraol
Anhydrous Glucose ,(S)
Glucose, unspecified form
Dextrose, unspecified form
Purified glucose (JP17)
Epitope ID:142342
D-(+)-DEXTROSE
DSSTox_RID_76784
DSSTox_RID_82925
DSSTox_GSID_22910
DSSTox_GSID_48729
GTPL4536
CHEMBL1222250
BDBM34103
DTXSID501015215
DTXSID901015217
Tox21_113165
Tox21_200145
AKOS025147374
NSC 287045
CAS-50-99-7
NCGC00166293-01
NCGC00257699-01
BS-48662
CAS-58367-01-4
G0048
(3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-
C00031
D00009
Q37525
Q23905964
N_FULL/O_FULL_10000000000000_GS_656
D-glucose (closed ring structure, complete stereochemistry)
WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/
GLUCOSE-FRUCTOSE SYRUP
Glucose-fructose Syrup, also known as glucose–fructose, isoglucose and glucose–fructose syrup, is a sweetener made from corn starch.
As in the production of conventional corn syrup, the starch is broken down into glucose by enzymes.
To make Glucose-fructose Syrup, the corn syrup is further processed by D-xylose isomerase to convert some of its glucose into fructose.



Fructose Glucose Syrup, High Fructose Corn Syrup, High-fructose corn syrup (HFCS),



Glucose-fructose Syrup was first marketed in the early 1970s by the Clinton Corn Processing Company, together with the Japanese Agency of Industrial Science and Technology, where the enzyme was discovered in 1965.
Glucose-fructose Syrup is a highly refined and concentrated solution of fructose, dextrose, maltose and higher saccharides.


Glucose-fructose Syrup is obtained by acid or enzymatic hydrolysis of corn or wheat starch.
When Glucose-fructose Syrup is made from corn, it is often called High Fructose Corn Syrup (HFCS).
Glucose-fructose Syrup is a plant-based sugar, made from grains.


EU starch manufacturers only use conventional (nonGMO) wheat and maize which are almost exclusively domestically produced.
Unlike glucose syrup which contains no fructose, Glucose-fructose Syrup is made up of two simple sugars: glucose and fructose.
Unlike sucrose (white sugar), which has a 50% fructose / 50% glucose content, its fructose content may vary.


The EU, which has a high volume and variety of agricultural crops, produces sugar from beet crops (sucrose) and from grains, for example glucosefructose syrup.
These are used in a number of different drinks and food products, not only for their sweetening properties but also for additional useful properties which make them an important ingredient in certain recipes.


Glucose-fructose Syrup comes in liquid form which makes it easier to mix with products such as drinks, than solid sugars.
Glucose-fructose Syrup can provide texture, volume, taste, glossiness, improved stability and a longer shelf-life for the products to which it is added.
Glucose-fructose Syrup also adds sweetness, at a level somewhere between glucose syrup and sucrose, in accordance with its fructose content.


Glucose-fructose Syrup is a sugar of natural origin.
In the EU Glucose-fructose Syrup is derived from (non-GMO) wheat and maize starch.
Glucose-fructose Syrup is a high-quality ingredient produced in EU starch manufacturing plants, employing over 15,000 workers.


Their raw materials are sourced almost exclusively from EU crops.
The average composition of Glucose-fructose Syrup in the EU is 70-80% glucose and 20-30% fructose.
The average consumption of fructose from Glucose-fructose Syrup sources in France is just 2g per person per day (of a daily total of 42g).


Glucose-fructose Syrup is part of the carbohydrates food group.
They have a calorific value of 4 kcal/g.
The European Food Safety Authority (EFSA) recommends that carbohydrates form 45-60% of our overall energy intake, stating that “enjoyed occasionally and in reasonable quantity, sweetened products are compatible with a balanced diet”.


Scientific studies have examined the effect of Glucose-fructose Syrup consumption on health.
Glucose-fructose Syrup is derived from corn or wheat starch – give food and beverages sweetness, nutritive, sensory and physical properties.
Glucose-fructose Syrup is an aqueous syrup containing glucose, fructose, maltose and oligosaccharides.


Glucose-fructose Syrup is obtained from starch by enzymatic hydrolysis.
Glucose-fructose Syrup is a clear and colourless liquid, with low viscosity.
Glucose-fructose Syrup is the purified and condensed natural glucose-fructose syrup, which contains fructose, is obtained after the hydrolysis of corn starch.


Glucose-fructose Syrup is clear, colorless and odorless.
It is the purified and condensed natural glucose-fructose syrup is obtained after the hydrolysis of corn starch.
Glucose-fructose Syrup is clear, colorless and natural.


Glucose-fructose Syrup is a source of fermentable carbohydrates.
Glucose-fructose Syrup is a transparent to light yellow liquid that is slightly viscous and has a clean, sweet taste.
Glucose-fructose Syrup is a sweet liquid which is made of glucose and fructose.


The content of fructose may vary from 5% to 50%.
Glucose-fructose Syrup is a natural sugar found in honey, fruits and some root vegetables.
Glucose-fructose Syrup is extremely user-friendly, as it comes in a handy squeeze bottle.


The anti-drip drop also guarantees Glucose-fructose Syrup will last a long time.
By an enzymatic process, the syrup rich in D-Glucose is isomerized obtaining Glucose-fructose Syrups.
Glucose-fructose Syrups include several products with varying concentrations of glucose and fructose.


Glucose-fructose Syrup is available with varying content of fructose.
Fructose has a higher sweetening power than glucose and a faster-released sweetness profile.
Glucose-Fructose syrup is a natural sweetener, a homogeneous, colorless, viscous odorless liquid with a pure sweet taste.


Glucose-fructose Syrup is obtained from wheat starch by its sequential enzymatic liquification and saccharification to high glucose content with partial isomerization of it into fructose.
The concentration of dry substances in the Glucose-fructose Syrup is 77%, of which the content of fructose for dry substances is 55%, glucose – 38%.


Glucose-fructose Syrup is a natural sweetener, produced fromcorn by successive enzymatic dilution and saccharification ofstarch to a high glucose syrup.
After the part of the glucose has been conversed to a fructose, the syrup is put to purification byion-exchange processes, disinfected on bactericidal filters with the dimension of pores 0,45 um. and concentrated.


Glucose-fructose Syrup contains glucose, fructose, disaccharide- maltose.
Glucose-fructose Syrup doesn't content artificial and synthetic substances as well as food additives.
In the production process Glucose-fructose Syrupnot used a genetically modified raw materialand the final product is of permanent guaranteed quality.



USES and APPLICATIONS of GLUCOSE-FRUCTOSE SYRUP:
Thanks to its sweet taste, Glucose-fructose Syrup is used as a sugar substitute.
As a sweetener, Glucose-fructose Syrup is often compared to granulated sugar, but manufacturing advantages of Glucose-fructose Syrup over sugar include that it is cheaper.


Glucose-fructose Syrup is mainly used for processed foods and breakfast cereals.
Glucose-fructose Syrup is designed to be used in the manufacture of
certain products.


Glucose-fructose Syrup has complementary properties to white sugar (sucrose).
Glucose-fructose Syrup is a simple carbohydrate.
Sugars, in common with all foodstuffs, should be consumed in reasonable quantities and as part of a healthy, varied diet and in accordance with the body’s physical demands.


Glucose-fructose Syrup is used jam, halvah, Turkish delight, confectionery, ice cream, desserts, jellies, bakery products, marmalade.
Glucose-fructose Syrup is used Food, Bakery Products and Biscuits, Halvah, Ice Cream, Jam and Marmalade, Jellies.
The main reasons for using Glucose-fructose Syrup in foods and drinks are its sweetness and the ability to blend nicely with other ingredients.


Interestingly, Glucose-fructose Syrup can be also used in place of additives for food preservation (an effect also observed with table sugar).
This helps to fulfil the needs of consumers when they desire products without additives.
Apart from better stability, Glucose-fructose Syrup can also improve the texture, prevent crystallisation, and help to achieve desired consistency (crispy versus moist).


In Europe, sucrose is still the main caloric sweetener used in the production of food and drinks.
The production of Glucose-fructose Syrup in the EU was regulated by the European Sugar Regime and was limited to 5% of total sugar production.
However, in October 2017 the regime ended, and the production of Glucose-fructose Syrup is estimated to increase from 0,7 to 2,3 million tonnes a year.


As a consequence, in the future, Glucose-fructose Syrup may replace sucrose in certain products, mainly in liquid or semi-solid foods, such as drinks and ice cream.
Glucose-fructose Syrup will continue being used for confectionery, jams and preserves, baked goods, cereal products, dairy products, condiments and canned and packed goods.


Glucose-fructose Syrup is a sweetening ingredient widely used in a variety of food products.
In the US, Glucose-fructose Syrup (or HFCS) is more commonly used than in Europe, typically in soft drinks where the HFCS with fructose content of at least 42% is used.


Glucose-fructose Syrup is used fruit juices, soft drink, energy drink, biscuits, bakery products, cakes, caramel, sauce, ketchup and narghile tobacco
Glucose-fructose Syrup is used fillings bakery products pastries confectionery fruit mixtures ice cream fruit juice and concentrate jam gingerbread
Glucose-fructose Syrup can be used in place of additives for food preservation.


Glucose-fructose Syrup is used as a sweetner in canned fruits, flavoured yogurts, jams and other baked food products.
Glucose-fructose Syrup is used as a sweetener, a replacement for sucrose, and to enhance flavor.
Glucose-fructose Syrup can be used to in the production of beverages, processed fruit, sweet bakery, ice creams, dairy desserts, puddings, yogurts and fermented drinks, as well as sauces and dressings.


Glucose-fructose Syrup is used in functional foods and nutrition applications.
Glucose-Fructose Syrup is used in making jam, halvah, Turkish delight, confectionery, ice cream, jellies, bakery products, marmelade.
Glucose-fructose Syrup is indispensable basic ingredients for every chef.


With Glucose-fructose Syrup you can make numerous desserts and sorbets.
Or you can use Glucose-fructose Syrup as a sweetener for your cocktails.
Glucose-fructose Syrup is used Soft drinks and Sauces.


Glucose-fructose Syrups share many of the applications of glucose syrups.
However, Glucose-fructose Syrup is in the production of soft drinks and sauces that its greatest application is verified.
The use of Glucose-fructose Syrups contributes to the ideal degree of sweetness, helps to optimize production costs and offers consumers more options.


Glucose-fructose Syrup is a substance used as a sugar substitute for making foods.
Glucose-fructose Syrup is several times sweeter than sugar, mixes more easily with the texture of the product and extends its shelf life.
Based on the composition of HPS, Glucose-fructose Syrup is almost identical in physicochemical and organoleptic characteristics to sucrose, and does not contain artificial or synthetic substances, as well as food additives.


The production does not use genetically modified raw materials, and the resulting Glucose-fructose Syrup has consistently guaranteed quality.
Replacing sugar with Glucose-fructose Syrup is possible throughout the group of bakery and confectionery products, and is also widely used in the production of soft drinks, baby food, canned food, in the confectionery and dairy industries.


Glucose-fructose Syrup is an essential component of dietary products for people with diabetes, and for the healthy nutrition of athletes.
Glucose-fructose Syrup is the most popular sugar substitute among many other natural sweeteners.
Glucose-fructose Syrup is widely used all over the world and, in terms of its technological and organoleptic characteristics, competes with cane and beet sugar, therefore it is in great demand in the food industry today.


Glucose-fructose Syrup is used in soft drinks; In baby food; in canned food; in the confectionery industry; and in the dairy industry.
End Uses of Glucose-fructose Syrup: Canned Fruits, Candies, Filling Applications, Jams, Marmalades
Depending on the fructose/glucose ratio, the perceived sweetness will differ.


An increased fructose content will also help to reduce crystallization tendency.
They are ideal for use in fillings of chocolate products, fruit preparations, fruity syrups, fruit juice, ice cream, and other sweet treats.
​Glucose-fructose Syrup is used in the food industry as a part of food products instead of sugar in the production of soft drinks, juices, high-quality bakery products, desserts, dairy products, fruit and berry preserves, fruit fillers, sauces and much more.


As a sweetener, Glucose-fructose Syrup is traditionally used in carbonated drinks, in baking applications – acts as a fermentable sugar, a sweetener and humectant, in breads, buns, rolls and yeast raised donuts – ferments directly without the need for sugar inversion.
In ice cream and other dairy products such as chocolate milk, Glucose-fructose Syrup is effective in enhancing their textural and sparsity properties, especially in chocolate milk.


The presence of free fructose in the syrup allows positioning the finished product as a partially dietary product and enhances fruit and other flavors, which significantly reduces the amount of flavors used in the formulations.
The properties of Glucose-fructose Syrup stipulate its use in most sweet foods.


Common uses include baked goods, sodas, yogurts and condiments in such systems, Glucose-fructose Syrup can provide sweetness, moisture retention, texture and flavor enhancing, color stabilization, stability and cost reduction.
Glucose-fructose Syrup also can influence the freezing point, scoopability and dispersing of ice creams.


-Food application of glucose-fructose
Glucose-fructose Syrup, Food Application Syrups with a higher fructose content is used mainly for their sweetening power since this is the sweetest of the elemental sugars.
In addition, Glucose-fructose Syrup has a synergistic effect when mixed with other sweeteners, both natural and artificial.



HEALTH BENEFITS OF GLUCOSE-FRUCTOSE SYRUP:
*Glucose-fructose Syrup is a good source of carbohydrates.
*Glucose-fructose Syrup helps in producing energy in the body.
*Vegetarian
*Taste Profile
*Glucose-fructose Syrup has a sweet taste.



CHARACTERISTICS OF GLUCOSE-FRUCTOSE SYRUP:
*Glucose-fructose Syrup has a clear, colorless texture
*Glucose-fructose Syrup provides desired stability of the finished products
*Glucose-fructose Syrup increases brightness in final product
*Glucose-fructose Syrup improves textures
*Glucose-fructose Syrup increases brightness in final product
*Glucose-fructose Syrup prevents microbiological activity
*Glucose-fructose Syrup prolongs the shelf life
*Glucose-fructose Syrup has a non-masking effect
*Glucose-fructose Syrup improves mouth-feel and sweetness, helps to achieve varying levels of caramelized color.



BENEFITS OF GLUCOSE-FRUCTOSE SYRUP:
*properties similar to honey and invert sugar syrup
*intense sweetener because of high fruit sugar content
*alternative to agave syrup



GENERAL BENEFITS OF GLUCOSE-FRUCTOSE SYRUP:
*Glucose-fructose Syrup provides a higher and clean, balanced sweetening effect than conventional Glucose Syrups
*Glucose-fructose Syrup enhances fruit flavours in your fruit containing products like jam, fruit preparations and marmalades
*You can create an improved visual appeal and gloss of your end product
*Glucose-fructose Syrup lowers the freezing point, with textural improvements in frozen products
*Extends shelf-life due to humectancy in candy bars and soft baked goods
*Glucose-fructose Syrup is suitable for aerated confectionery like marshmallows and chocolate marshmallows
*Easy, hazzle-free processing
*Kosher and Halal certificates are available upon request



WHAT IS A GLUCOSE-FRUCTOSE SYRUP AND HOW IS GLUCOSE-FRUCTOSE SYRUP MADE?
Glucose-fructose Syrup is a sweet syrup made from starch extracted from grains and vegetables.
Glucose-fructose Syrup has a similar composition to table sugar which is made from sugar cane or beet – they both consist of glucose and fructose, albeit in different proportions.

Table sugar consists of 50% fructose and 50% glucose.
Glucose-fructose Syrup mades in the EU typically contain 20, 30 or 42% of fructose and the rest is glucose.
A fascinating thing about Glucose-fructose Syrup is that when extracting it from starch, the starch producers can regulate the amount of fructose in it to make the syrup as sweet as table sugar or less sweet, if needed.

If the Glucose-fructose Syrup is made to be as sweet as table sugar, it is often used as an alternative.
It is easier to use Glucose-fructose Syrup than table sugar in some foods because these syrups are liquid unlike table sugar, which is crystallised.
Thus, Glucose-fructose Syrup is easier to blend with other ingredients in creams, ice creams, drinks and other liquid or semi-liquid foods.



WHAT IS THE DIFFERENCE BETWEEN GLUCOSE-FRUCTOSE AND GLUCOSE-FRUCTOSE SYRUP?
Just like table sugar (sucrose), glucose – fructose and fructose-glucose syrup are also made up of glucose and fructose.
While table sugar has a fixed proportion of 50% glucose and 50% fructose, the percentage of these molecules in syrups may vary.
If a syrup contains more than 50% of fructose, it is called “fructose-glucose syrup” on the packaging.
If there is less than 50% fructose in it, it is called “glucose-fructose syrup”.
The typical fructose content of such syrups produced in Europe is 20, 30, and 42%.



BEEKEEPING, GLUCOSE-FRUCTOSE SYRUP:
In apiculture in the United States, Glucose-fructose Syrup is a honey substitute for some managed honey bee colonies during times when nectar is in low supply.
However, when Glucose-fructose Syrup is heated to about 45 °C (113 °F), hydroxymethylfurfural, which is toxic to bees, can form from the breakdown of fructose.

Although some researchers cite honey substitution with Glucose-fructose Syrup as one factor among many for colony collapse disorder, there is no evidence that HFCS is the only cause
Compared to hive honey, both Glucose-fructose Syrup and sucrose caused signs of malnutrition in bees fed with them, apparent in the expression of genes involved in protein metabolism and other processes affecting honey bee health.



ARE GLUCOSE-FRUCTOSE SYRUP, ISOGLUCOSE AND HIGH FRUCTOSE CORN SYRUP (HFCS) THE SAME THING?
There is a lot of confusion around the terms Glucose-fructose Syrup, isoglucose and high fructose corn syrup which are often used interchangeably.
Glucose-fructose Syrup may be called differently depending on the country and the fructose content.
In Europe, due to ‘isomerisation’ process, Glucose-fructose Syrup with more than 10% fructose is called isoglucose.

In turn, when the fructose content exceeds 50%, the name changes to Fructose-Glucose Syrup to reflect the higher content of fructose.
In the United States, the syrup is produced from a maize starch, usually with either 42% or 55% fructose content, hence it is called High Fructose Corn Syrup.



FOOD, GLUCOSE-FRUCTOSE SYRUP:
In the U.S., Glucose-fructose Syrup is among the sweeteners that mostly replaced sucrose (table sugar) in the food industry.
Factors contributing to the increased use of Glucose-fructose Syrup in food manufacturing include production quotas of domestic sugar, import tariffs on foreign sugar, and subsidies of U.S. corn, raising the price of sucrose and reducing that of Glucose-fructose Syrup, making it a lower cost for manufacturing among sweetener applications.

In spite of having a 10% greater fructose content, the relative sweetness of Glucose-fructose Syrup, used most commonly in soft drinks, is comparable to that of sucrose.
Glucose-fructose Syrup provides advantages in food and beverage manufacturing, such as simplicity for formulation and stability, enabling processing efficiencies.

Glucose-fructose Syrup is the primary ingredient in most brands of commercial "pancake syrup", as a less expensive substitute for maple syrup.
Assays to detect adulteration of sweetened products with Glucose-fructose Syrup, such as liquid honey, use differential scanning calorimetry and other advanced testing methods.



WHAT ARE GLUCOSE AND FRUCTOSE?
Glucose is a simple sugar, a so-called monosaccharide, because it is made up of just one sugar unit.
It is found naturally in many foods, and it is used by our bodies as a source of energy to carry out daily activities.
Fructose is also a simple sugar, often referred to as a fruit sugar.

Fructose, as the name suggest, is found in fruits (such as oranges and apples), berries, some root vegetables (such as beets, sweet potatoes, parsnips, and onions) and honey.
Fructose is the sweetest of all naturally occurring sugars.
Glucose and fructose bound together in equal amounts create another type of sugar – sucrose – a disaccharide commonly known as table sugar.



WHAT IS GLUCOSE-FRUCTOSE SYRUP?
Glucose-fructose Syrup is a sweet liquid made of glucose and fructose.
Unlike sucrose, where 50% of glucose and 50% of fructose are linked together, Glucose-fructose Syrup can have a varying ratio of the two simple sugars, meaning that some extra, unbound glucose or fructose molecules are present.
The fructose content in Glucose-fructose Syrup can range from 5% to over 50%.



HOW IS GLUCOSE-FRUCTOSE SYRUP MADE?
Glucose-fructose Syrup is typically made from starch.
The source of starch depends on the local availability of the raw product used for extraction.
Historically, maize was a preferred choice, while in recent years wheat became a popular source for Glucose-fructose Syrup production.

Starch is a chain of glucose molecules, and the first step in Glucose-fructose Syrup production involves freeing those glucose units.
The linked glucose molecules in starch are cut down (hydrolysed) into free glucose molecules.
Then, with the use of enzymes, some of the glucose is changed into fructose in a process called isomerisation.



WHAT IS THE NUTRITIONAL VALUE OF GLUCOSE-FRUCTOSE SYRUP?
Glucose-fructose Syrup is a source of carbohydrates, which along with proteins and fats are the foundation of our diet.
The human body uses Glucose-fructose Syrup for energy, development and maintenance.
Glucose-fructose Syrup is nutritionally equivalent to other carbohydrates, containing the same number of 4 kcal per gram, and has the health impact of added sugars.



SAFETY AND MANUFACTURING CONCERNS OF GLUCOSE-FRUCTOSE SYRUP:
Since 2014, the United States FDA has determined that Glucose-fructose Syrup is safe (GRAS) as an ingredient for food and beverage manufacturing, and there is no evidence that retail HFCS products differ in safety from those containing alternative nutritive sweeteners.



COMMERCE AND CONSUMPTION OF GLUCOSE-FRUCTOSE SYRUP:
The global market for Glucose-fructose Syrup is expected to grow from $5.9 billion in 2019 to a projected $7.6 billion in 2024.

*China:
Glucose-fructose Syrup in China makes up about 20% of sweetener demand.
Glucose-fructose Syrup has gained popularity due to rising prices of sucrose, while selling for a third the price.
Production was estimated to reach 4,150,000 tonnes in 2017.
About half of total produced Glucose-fructose Syrup is exported to the Philippines, Indonesia, Vietnam, and India.


*European Union:
In the European Union (EU), HFCS is known as isoglucose or glucose-fructose syrup (GFS) which has 20–30% fructose content compared to 42% (HFCS 42) and 55% (HFCS 55) in the United States.
While HFCS is produced exclusively with corn in the US, manufacturers in the EU use corn and wheat to produce Glucose-fructose Syrup.

Glucose-fructose Syrup was once subject to a sugar production quota, which was abolished on 1 October 2017, removing the previous production cap of 720,000 tonnes, and allowing production and export without restriction.

Use of Glucose-fructose Syrup in soft drinks is limited in the EU because manufacturers do not have a sufficient supply of GFS containing at least 42% fructose content.
As a result, soft drinks are primarily sweetened by sucrose which has a 50% fructose content.


*Japan:
In Japan, Glucose-fructose Syrup is also referred to as isomerized sugar.
Glucose-fructose Syrup production arose in Japan after government policies created a rise in the price of sugar.
Japanese Glucose-fructose Syrup is manufactured mostly from imported U.S. corn, and the output is regulated by the government.
For the period from 2007 to 2012, Glucose-fructose Syrup had a 27–30% share of the Japanese sweetener market.

Japan consumed approximately 800,000 tonnes of Glucose-fructose Syrup in 2016.
The United States Department of Agriculture states that corn from the United States is what Japan uses to produce their Glucose-fructose Syrup.
Japan imports at a level of 3 million tonnes per year, leading 20 percent of corn imports to be for Glucose-fructose Syrup production.


*Mexico:
Mexico is the largest importer of U.S. Glucose-fructose Syrup.
Glucose-fructose Syrup accounts for about 27 percent of total sweetener consumption, with Mexico importing 983,069 tonnes of HFCS in 2018.
Mexico's soft drink industry is shifting from sugar to Glucose-fructose Syrup which is expected to boost U.S.
Glucose-fructose Syrup exports to Mexico according to a U.S. Department of Agriculture Foreign Agricultural Service report.


*Philippines:
The Philippines was the largest importer of Chinese HFCS.
Imports of Glucose-fructose Syrup would peak at 373,137 tonnes in 2016.


*United States:
In the United States, Glucose-fructose Syrup was widely used in food manufacturing from the 1970s through the early 21st century, primarily as a replacement for sucrose because its sweetness was similar to sucrose, it improved manufacturing quality, was easier to use, and was cheaper.
Domestic production of Glucose-fructose Syrup increased from 2.2 million tons in 1980 to a peak of 9.5 million tons in 1999.

Although Glucose-fructose Syrup use is about the same as sucrose use in the United States, more than 90% of sweeteners used in global manufacturing is sucrose.
Production of Glucose-fructose Syrup in the United States was 8.3 million tons in 2017.

Glucose-fructose Syrup is easier to handle than granulated sucrose, although some sucrose is transported as solution.
Unlike sucrose, Glucose-fructose Syrup cannot be hydrolyzed, but the free fructose in HFCS may produce hydroxymethylfurfural when stored at high temperatures; these differences are most prominent in acidic beverages.

Soft drink makers such as Coca-Cola and Pepsi continue to use sugar in other nations but transitioned to Glucose-fructose Syrup for U.S. markets in 1980 before completely switching over in 1984.
Consumption of Glucose-fructose Syrup in the U.S. has declined since it peaked at 37.5 lb (17.0 kg) per person in 1999.

The average American consumed approximately 22.1 lb (10.0 kg) of Glucose-fructose Syrup in 2018, versus 40.3 lb (18.3 kg) of refined cane and beet sugar.
This decrease in domestic consumption of Glucose-fructose Syrup resulted in a push in exporting of the product.
In 2014, exports of Glucose-fructose Syrup were valued at $436 million, a decrease of 21% in one year, with Mexico receiving about 75% of the export volume.


*Vietnam:
90% of Vietnam's Glucose-fructose Syrup import comes from China and South Korea.
Imports would total 89,343 tonnes in 2017.
One ton of Glucose-fructose Syrup was priced at $398 in 2017, while one ton of sugar would cost $702.



HEALTH, GLUCOSE-FRUCTOSE SYRUP:
Nutrition:
Glucose-fructose Syrup is 76% carbohydrates and 24% water, containing no fat, protein, or micronutrients in significant amounts.
In a 100-gram reference amount, Glucose-fructose Syrup supplies 281 calories, while in one tablespoon of 19 grams, it supplies 53 calories.

Obesity and metabolic syndrome:
The role of fructose in metabolic syndrome has been the subject of controversy, but as of 2022, there is no scientific consensus that fructose or Glucose-fructose Syrup has any impact on cardiometabolic markers when substituted for sucrose.



PHYSICAL and CHEMICAL PROPERTIES of GLUCOSE-FRUCTOSE SYRUP:
Appearance: Viscous liquid
Colour: Colourless to yellow
Aroma: Characteristic
Flavour: Swee



FIRST AID MEASURES of GLUCOSE-FRUCTOSE SYRUP:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person. Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GLUCOSE-FRUCTOSE SYRUP:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GLUCOSE-FRUCTOSE SYRUP:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLUCOSE-FRUCTOSE SYRUP:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of GLUCOSE-FRUCTOSE SYRUP:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.



STABILITY and REACTIVITY of GLUCOSE-FRUCTOSE SYRUP:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



GLUCOSIDE
Glucoside is natural ingredients modified by a chemical process called glycosylation.
Glycosylation makes the ingredients (vitamins and compounds from natural extracts) more stable, bio-available, and water-soluble in formulations.
There are many glycosides in the planting and animal world.


For healing methods, important glycosides are: arbutine in the leaves of Bearberries, salicine in willow bark, anthraglucosides in Rhubarb, and refuse trees.
Also, the anthocyans as red and blue dyes of flowers and berries are glycosides.


Again other important glucosides are saponins (triterpenoids).
The name saponins come to foam from their quality in a watery solution strongly (Sapo is in the Latin soap).
Glucoside is a new generation of commercially available, biodegradable surfactants.


Glucoside produces stable foam to enhance the texture and cleansing properties of cosmetics and personal care products.
Glucoside is natural ingredients modified by a chemical process called glycosylation.
Glycosylation makes the ingredients (vitamins and compounds from natural extracts) more stable, bio-available, and water-soluble in formulations.


Some glucosides are perfect emollients that also improve the skin's water contents.
These parts of beauty formulas can moisturize and soften skin and hair.
Glucoside is compounds consisting of a sugar molecule (typically a monosaccharide) attached to a functional group through a glycosidic bond.


A glucoside is a glycoside that is chemically derived from glucose.
Glucosides are common in plants, but rare in animals.


Glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes.
The name was originally given to plant products of this nature, in which the other part of the molecule was, in the greater number of cases, an aromatic aldehydic or phenolic compound (exceptions are Jinigrin and Jalapin or Scammonin).


It has now been extended to include synthetic ethers, such as those obtained by acting on alcoholic glucose solutions with hydrochloric acid, and also the polysaccharoses, e.g. cane sugar, which appear to be ethers also.


Although glucose is the most common sugar present in glucosides, many are known which yield rhamnose or iso-dulcite; these may be termed pentosides. Much attention has been given to the non-sugar parts (aglyca) of the molecules; the constitutions of many have been determined, and the compounds synthesized; and in some cases the preparation of the synthetic glucoside effected.


There are many glycosides in the planting and animal world.
For healing methods, important glycosides are: arbutine in the leaves of Bearberries, salicine in willow bark, anthraglucosides in Rhubarb, and refuse trees.


Also, the anthocyans as red and blue dyes of flowers and berries are glycosides.
Again other important glucosides are saponins (triterpenoids).
The name saponins come to foam from their quality in a watery solution strongly (Sapo is in the Latin soap).


A glucoside is a glycoside that is chemically derived from glucose.
Glucoside is common in plants, but rare in animals.
Glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes.


The name of Glucoside was originally given to plant products of this nature, in which the other part of the molecule was, in the greater number of cases, an aromatic aldehydic or phenolic compound (exceptions are Jinigrin and Jalapin or Scammonin).
Glucoside has now been extended to include synthetic ethers, such as those obtained by acting on alcoholic glucose solutions with hydrochloric acid, and also the polysaccharoses, e.g. cane sugar, which appear to be ethers also.


Although glucose is the most common sugar present in glucosides, many are known which yield rhamnose or iso-dulcite; these may be termed pentosides.
Much attention has been given to the non-sugar parts (aglyca) of the molecules; the constitutions of many have been determined, and the compounds synthesized; and in some cases the preparation of the synthetic glucoside effected.


The simplest glucosides are the alkyl ethers which have been obtained by reacting hydrochloric acid on alcoholic glucose solutions.
A better method of preparation is to dissolve solid anhydrous glucose in methanol containing hydrochloric acid.
A mixture of alpha- and beta-methylglucoside results.



USES and APPLICATIONS of GLUCOSIDE:
Made from vegetable oils and starch, alkyl glucosides (also called alkylpolyglucosides) are in demand for their performance, mildness, and low ecotoxicity.
Alkylpolyglucosides are a unique class of non-ionic surfactants for broad applications in skin and hair care products.
Those are widely used in consumer products found on virtually every store shelf, ranging from baby shampoos, facial cleansers, and makeup removers.


Alkyl glucosides meet the demand for mild, environmentally green, and powerful ingredients.
Usually derived from sugars, such as glucose derivatives and fatty alcohols, Alkyl Polyglucosides have gained a stellar reputation as high-performance components for cosmetic preparations.


Their organic and eco-friendly nature is another reason why formulators turn to AGPs when creating all-natural vegan cosmetic products.
Glycosylation makes the ingredients (vitamins and compounds from natural extracts) more stable, bio-available, and water-soluble in formulations.
Some glucosides are perfect emollients that also improve the skin's water contents.


These parts of beauty formulas can moisturize and soften skin and hair.
100% naturally derived very mild surfactants, Glucoside is commonly used for their emulsifying, and conditioning properties, and to enhance foaming.
Made from vegetable oils and starch, alkyl glucosides (also called alkylpolyglucosides) are in demand for their performance, mildness, and low ecotoxicity.


Alkylpolyglucosides are a unique class of non-ionic surfactants for broad applications in skin and hair care products.
Those are widely used in consumer products found on virtually every store shelf, ranging from baby shampoos, facial cleansers, and makeup removers.
Alkyl glucosides meet the demand for mild, environmentally green, and powerful ingredients.



SOEM OTHER PLEASING ATTRIBUTES OF GLUCOSIDE:
●Mild surfactants:
Glucoside is a mild and gentle surfactants that lower the surface tension of products it’s added to, helping them remove dirt and oils more effectively from the skin and hair.

●High-foaming properties:
Glucoside was first used in soaps and body cleansers because of its incredible foaming power.
Glucoside lathers easily and thickens while retaining skin moisture, even when used daily.

●Derived from natural sources:
Glucoside is obtained from 100% renewable raw materials through a combination of plant-based alcohol and glucose, making them completely natural and safe for everyday use.

●Superior wetting properties: As a surfactant, Glucoside also improves your aqueous formulation’s ability to spread across different surfaces and lather foam that’s stable and long-lasting.

●Compatible with other surfactants:
Due to their mild nature, Glucoside works incredibly well as co-surfactants.
By reducing the total active requirements of other active ingredients, Glucoside offers cleansing effectiveness, foam volume, and ease of thickening without altering the performance of the final product.



CHEMISTRY OF GLUCOSIDE:
Glucoside surfactants are also known as sugar surfactants.
They are good foaming, solubilising and wetting agents and are well suited to skin cleansing formulations where they are often used as tertiary surfactants (blended with anionic and amphoterics).

While glucosides can be used in shampoos and hair formulations, their use at high levels is not recommended as their chemistry means they tend to tangle and dry the hair.

As glucosides are produced by a polymerisation reaction they don't have an exact chemistry (chain length) so Decyl, Caprylyl/Capryl and Coco Glucoside cross over in their properties.
Due to this, in most formulations there is little benefit in adding more than one glucoside type to each formula.



THE CLASSIFICATION OF GLUCOSIDES:
The classification of glucosides is a matter of some intricacy.
One method based on the chemical constitution of the non-glucose part of the molecules has been proposed that posits four groups:
(I) alkyl derivatives,
(2) benzene derivatives,
(3) styrolene derivatives, and
(4) anthracene derivatives.
A group may also be constructed to include the cyanogenic glucosides, i.e. those containing prussic acid.
Alternate classifications follow a botanical classification, which has several advantages; in particular, plants of allied genera contain similar compounds.


*Ethylene derivatives
These are generally mustard oils, which are characterized by a burning taste; their principal occurrence is in mustard and Tropaeolum seeds.
Sinigrin, or the potassium salt of inyronic acid not only occurs in mustard seed, but also in black pepper and in horseradish root.

Hydrolysis with barium hydroxide, or decomposition by the ferment myrosin, gives glucose, allyl mustard oil and potassium hydroxide.
Sinalbin occurs in white pepper; it decomposes to the mustard oil, glucose and sinapin, a compound of choline and sinapic acid.
Jalapin or Scammonin occurs in scammony; it hydrolyses to glucose and jalapinolic acid.


*Benzene derivatives
These are generally oxy and oxyaldehydic compounds.


*Benzoic acid derivatives
The benzoyl derivative cellotropin has been used for tuberculosis. Populin, which occurs in the leaves and bark of Populus tremula, is benzoyl salicin.
Benzoyl-beta-D-glucoside is a compound found in the fern Pteris ensiformis.


*Phenol derivatives
There are a number of glucosides found in natural phenols and polyphenols, as, for example, in the flavonoids chemical family.
Arbutin, which occurs in bearberry along with methyl arbutin, hydrolyses to hydroquinone and glucose.

Pharmacologically it acts as a urinary antiseptic and diuretic; Salicin, also termed Saligenin and glucose occurs in the willow.
The enzymes ptyalin and emulsin convert it into glucose and saligenin, ortho-oxybenzylalcohol.
Oxidation gives the aldehyde helicin.



HOW ARE GLUCOSIDE SURFACTANTS MADE?
Alkyl Polyglucoside is a nonionic surfactant, prepared by the glycosylation of starch or monomer glucose with fatty alcohols.
The optimum surface activity is obtained with an alkyl chain of C8 to C16.
If you want to create safe formulations for soaps, shampoos, body washes, creams, lotions, or other personal care items, Alkyl Polyglucosides is your safest bet.

Types Of Glucosides:
You can make many kinds of Alkyl Glucosides by combining different ingredients with the carbon chain alcohol and cyclic glucose.
The most popularly used glucosides in the cosmetic industry include:

●Decyl glucoside
●Coco glucoside
●Lauryl glucoside
●Capryl glucoside

You may remember these names from shampoo labels or body wash products, but how does one type of Alkyl Polyglucoside differ from the other?
At first, they all look the same: a light or pale yellowish liquid with a DP (degree of polymerization) value of 1.3-1.5 and 50% solid content.
However, the main difference between these glucosides is their viscosity and foaming abilities.


1.Decyl Glucoside
Decyl glucoside is a versatile, plant-based surfactant that is produced from coconuts and cornstarch.
The carbon chain length used to make Decyl glucoside is 60% C8-C10 and 40% C12-C14.

By reacting decyl alcohol with cyclic glucose, this substance is drawn out of sugars and fatty acids by a process known as esterification.
With a viscosity level of 1000-2500 (mPa•s, 20℃), Decyl glucoside produces the fastest, wealthiest foam, but the foam also disappears quickly as compared to other Glucosides.

Its low viscosity also enhances the fluidity of your formulation.
Decyl glucoside is a great addition to products that require rich and dense foams, such as:

●Shampoos
●Conditioners
●Shower gels
●Bath oils
●Dermatological liquid soaps
●Hair colors
●Hair straightening products

Apart from its excellent foaming abilities, Decyl glucoside helps skin and hair retain moisture and keeps them healthy.
It also works very well with Cocamidopropyl betaine, which is an amphoteric surfactant with antistatic properties for hair care formulations.

According to the Cosmetics Ingredient Review, Decyl glucoside is safe for use in almost all topical applications or products, specifically in soaps, bubble baths, body washes, and detergents.

Regardless of what kind of product you want to try, Decyl glucoside has a good safety profile for all skin types and is 100% biodegradable - the perfect congenial ingredient to add to your creations if you are concerned about health, wellness, and the environment.


2.Coco Glucoside
When glucose reacts chemically with the fatty alcohols derived from Coconut oil, Coco glucoside: a natural, gentle, and environmentally friendly surfactant is formed.

Coco glucoside has a carbon chain length of 40% C8-C10 and 60% C12-C14.
With a viscosity of 2500-6000 (mPa•s, 20℃), Coco-Glucoside holds the middle ground between the foam stability of Decyl glucoside and Lauryl glucoside.
Sourced from coconut oil, this soothing, raw material has non-greasy, hydrating, and conditioning properties.

When added to skin and hair products, these properties help prevent the skin from drying out and smooth out the hair strands.
Since it is compatible with all other surfactants, you can mix it as a co-surfactant without risking the stability, or the foaming and cleansing capacity of the end product.

With its ultra-gentle cleansing properties, Coco glucoside is well-suited for all skin types and is the perfect addition to mild, natural formulations that are specially intended for sensitive skin.

Coco Glucoside is most commonly used in:
●Shampoos
●Conditioners
●Body washes
●Cleansers
●Hand soaps
●Body scrubs
●Acne treatments
●Facial moisturizers
●Hair dyes
●Baby products


3.Lauryl Glucoside
Lauryl glucoside is another non-ionic surfactant that is used as a foaming agent, viscosity builder, conditioner, and emulsifier.
It is formed by a carbon chain length of C12-C14 with a viscosity level of 2000-4000 (mPa•s, 40℃).
Since it comes from coconut or palm oil, it is biodegradable.

As a mild surfactant and cleansing agent, Lauryl glucoside breaks the surface tension, allowing dirt and oil to be removed easily.
This is one of the many reasons why formulators add Lauryl glucoside to baby cleansing products.
When compared to Coco glucoside and Decyl glucoside, Lauryl glucoside takes more time to foam.

But it also creates the most stable foam.
However, on rare occasions, some people may be allergic to glucosides and may develop irritation after using products containing Lauryl glucoside.
Therefore, it is recommended to always do a patch test before using products with lauryl glucoside.

Lauryl Glucoside is most commonly used in:
●Sunscreens
●Baby cleansing products
●Facial foams
●Cleansers
●Gels
●Hair cleansing products


4.Capryl Glucoside
Capryl glucoside is a highly effective natural and biodegradable surfactant that’s produced by the reaction of glucoside with capric alcohol.
This glucose alkyl ether is made from a carbon chain length of C8-C10 and contains 60% active matter.
It is ECOCERT certified and preservative-free.

Capryl glucoside is a clear to light yellow viscous liquid, which increases the foaming capacity and creates a fine and stable foam in skincare and haircare products.
In addition to being an excellent, gentle cleansing surfactant, Capryl glucoside is also a good solubilizer and emulsifier, allowing essential oils and water to mix.

Due to this dual-purpose, capryl glucoside is one of the easiest ingredients to work with and creates many types of formulations such as:
●Shower gels
●Shampoos
●Liquid hand soaps
●Creams
●Face washes


Conclusion
When you consider making your own cosmetic products, it is important to select natural and wholesome ingredients whenever possible.
You want to make sure that your products are naturally moisturizing and nourishing your skin and hair rather than drying it out or causing irritation.
By incorporating natural glucosides into your personal care products, you not only ensure your own safety but the safety of the environment with safe and eco-friendly formulas.



THE SIMPLEST GLUCOSIDES:
The simplest glucosides are the alkyl ethers which have been obtained by reacting hydrochloric acid on alcoholic glucose solutions.
A better method of preparation is to dissolve solid anhydrous glucose in methanol containing hydrochloric acid.
A mixture of alpha- and beta-methylglucoside results.


*Ethylene derivatives
These are generally mustard oils, which are characterized by a burning taste; their principal occurrence is in mustard and Tropaeolum seeds.
Sinigrin, or the potassium salt of inyronic acid not only occurs in mustard seed, but also in black pepper and in horseradish root.

Hydrolysis with barium hydroxide, or decomposition by the ferment myrosin, gives glucose, allyl mustard oil and potassium hydroxide.
Sinalbin occurs in white pepper; it decomposes to the mustard oil, glucose and sinapin, a compound of choline and sinapic acid. Jalapin or Scammonin occurs in scammony; it hydrolyses to glucose and jalapinolic acid.


*Benzene derivatives
These are generally oxy and oxyaldehydic compounds.


*Benzoic acid derivatives
The benzoyl derivative cellotropin has been used for tuberculosis. Populin, which occurs in the leaves and bark of Populus tremula, is benzoyl salicin.
Benzoyl-beta-D-glucoside is a compound found in the fern Pteris ensiformis.


*Phenol derivatives
There are a number of glucosides found in natural phenols and polyphenols, as, for example, in the flavonoids chemical family.
Arbutin, which occurs in bearberry along with methyl arbutin, hydrolyses to hydroquinone and glucose.

Pharmacologically it acts as a urinary antiseptic and diuretic; Salicin, also termed Saligenin and glucose occurs in the willow.
The enzymes ptyalin and emulsin convert it into glucose and saligenin, ortho-oxybenzylalcohol.
Oxidation gives the aldehyde helicin


*Styrolene derivatives
This group contains a benzene and also an ethylene group, being derived from styrolene.
Coniferin, C16H22O8, occurs in the cambium of conifer wood.
Emulsin converts it into glucose and coniferyl alcohol, while oxidation gives glycovanillin, which yields with emulsin, glucose and vanillin.

Syringin, which occurs in the bark of Syringa vulgaris, is a methoxyconiferin.
Phloridzus occurs in the root-bark of various fruit trees; it hydrolyses to glucose and phloretin, which is the phloroglucin ester of paraoxyhydratropic acid.

It is related to the pentosides naringin, C27H32O14, which hydrolyses to rhamnose and naringenin, the phioroglucin ester of para-oxycinnamic acid, and hesperidin, which hydrolyses to rhamnose and hesperetin, the phloroglucin ester of meta-oxy-para-methoxycinnamic acid or isoferulic acid, C10H10O4.

Aesculin (C21H24O13), occurring in horse-chestnut and California buckeye, and daphnin, occurring in Daphne alpina, are isomeric; the former hydrolyses to glucose and aesculetin (C9H6O4 — 6,7-dihydroxycoumarin), the latter to glucose and daphnetin (7,8-dihydroxycoumarin).

Fraxin, occurring in Fraxinus excelsior, and with aesculin, hydrolyses to glucose and fraxetin ( also known as 7,8-dihydroxy-6-methoxycoumarin)
Flavone or benzo-7-pyrone derivatives are numerous; in many cases they (or the non-sugar part of the molecule) are vegetable dyes.

Quercitrin is a yellow dyestuff found in Quercus velutina; it hydrolyses to rhamnose and quercetin, a dioxy-~3-phenyl-trioxybenzoy-pyrone.a
Rhamnetin, a splitting product of the glucosides of Rhamnus, is monomethyl quercetin; fisetin, from Rhus cotinus, is monoxyquercetin; chrysin is phenyl-dioxybenzo-y-pyrone.

Saponarin, a glucoside found in Saponaria officinalis, is a related compound.
Strophanthin is the name given to two different compounds, g-strophanthin (ouabain) obtained from Strophanthus gratus and k-strophanthin from Stroph. kombé.


*Anthracene derivatives
These are generally substituted anthraquinones; many have medicinal applications, being used as purgatives, while one, ruberythric acid, yields the valuable dyestuff madder, the base of which is alizarin.

Chrysophanic acid, a dioxymethylanthraquinone, occurs in rhubarb, which also contains emodin, a trioxymethylanthraquinone; this substance occurs in combination with rhamnose in Frangula bark.
Arguably the most important cyanogenic glucoside is amygdalin, which occurs in bitter almonds.

The enzyme maltase decomposes it into glucose and mandelic nitrile glucoside; the latter is broken down by emulsin into glucose, benzaldehyde and prussic acid.
Emulsin also decomposes amygdalin directly into these compounds without the intermediate formation of mandelic nitrile glucoside.

Several other glucosides of this nature have been isolated.
The saponins are a group of substances characterized by forming a lather with water; they occur in soap-bark.
Mention may also be made of indican, the glucoside of the indigo plant; this is hydrolysed by the indigo ferment, indimulsiri, to indoxyl and indiglucin



FIRST AID MEASURES of GLUCOSIDE:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GLUCOSIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GLUCOSIDE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLUCOSIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of GLUCOSIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.



STABILITY and REACTIVITY of GLUCOSIDE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


GLUCURONOLACTONE
Glucuronolactone is a white crystalline powder.
Glucuronolactone neutralizes poisons in the liver and intestines.
Glucuronolactone is a popular ingredient in energy drinks with claims that it detoxifies the body


CAS Number: 32449-92-6
EC Number: 251-053-3
MDL number: MFCD00135622
Chemical formula: C6H8O6



SYNONYMS:
Glucuronic acid-3,6-lactone, EINECS 251-053-3, BRN 0083595, NSC-656, D-Glucuronic acid, g-lactone, UNII-XE4Y3016M9, D-Glucuronic acid, gamma-lactone, D-Glucuronicacid,g-lactone, SCHEMBL28793, 5-18-05-00033 (Beilstein Handbook Reference), GLUCUROLACTONE [MART.], GLUCURONOLACTONE [INCI], D-GLUCURONOLACTONE [MI], GLUCUROLACTONE [WHO-DD], CHEBI:18268, D-glucofuranuronate gamma-lactone, AMY8977, BCP09805, AKOS006341990, KS-1361, gamma-Lactone of D-glucofuranuronic acid, HY-41982, CS-0019952, NS00013683, C02670, D-(+)-Glucuronic acid gamma-lactone, >=99%, D01800, D70547, .GAMMA-LACTONE OF D-GLUCOFURANURONIC ACID, Q28529701, D-(+)-Glucuronic acid gamma-lactone, analytical standard, 00CE759F-D1F9-492E-89F7-B7400A34C72D, D-Glucurone, D-Glucuronic acid, D-Glucuronic acid lactone, D-glucurono-3,6-Lactone, D-Glucuronolactone, Dicurone, glucofuranurono-6,3-Lactone, Glucoxy, Glucurolactone, Glucuron, Glucurone, Glucuronic acid lactone, Glucuronolactone, Glucuronosan, Gluronsan, Glycurone, Guronsan, Reulatt s.s., D-Glucurone, D-Glucurono-6,3-lactone, D-Glucuronic acid-gamma-lactone, D-Glucurono-6,3-lactone, (2R)-2-[(2S,3R,4S)-3,4-Dihydroxy-5-oxo-tetrahydrofuran-2-yl]-2-hydroxy-acetaldehyde, Glucuronic acid lactone, Glucurone, Glucurolactone (INN), D-glucurono-gamma-lactone, glucurono-γ-lactone, D-Glucurono-3,6-lactone, 32449-92-6, GLUCUROLACTONE, D-Glucurono-6,3-lactone, Glucurono-6,3-lactone, d(+)-glucurono-3,6-lactone, Glucuronosan, Guronsan, Glucurolactone [INN], D-Glucofuranuronic acid, gamma-lactone, Glucuronolactone [JAN], NSC 656, Glucuron, Gluronsan, Glucuronic acid lactone, XE4Y3016M9, Reulatt S.S., MFCD00135622, (R)-2-((2S,3R,4S)-3,4-dihydroxy-5-oxotetrahydrofuran-2-yl)-2-hydroxyacetaldehyde, Glucuronolactone (JAN), (2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde, Glucurolactonum, Glucurolactona, Glucuronolattone, Glucuronolattone [DCIT], gamma-Glukurolakton



Glucuronolactone is most commonly known as a popular component of energy drinks
Glucuronolactone is a normal human metabolite formed from glucose, but is only present in small amounts in the diet
In the body Glucuronolactone exists as in physiological equilibrium with glucuronic acid


Therefore supplementation with Glucuronolactone boosts glucuronic acid and association phase II glucuronidation
Supplementation with Glucuronolactone may improve liver function through its link with glucuronidation
Typical doses of Glucuronolactone in energy drinks and supplements are generally considered to be safe


Glucuronolactone is a glucuronic acid derivative that is converted to L-ascorbic acid in animals and humans.
Glucuronolactone is studied for its effectiveness against canine hepatitis.
Glucuronolactone is a naturally occurring solid white compound that has applications for bodybuilding and exercise.


Glucuronolactone is one of the lesser known ingredients, but there is evidence to suggest that it may be useful in increasing both physical and mental performance.
Glucuronolactone is a white crystalline powder.


Glucuronolactone neutralizes poisons in the liver and intestines.
Glucuronolactone is a popular ingredient in energy drinks with claims that it detoxifies the body
Glucuronolactone is a potent detoxification compound naturally found in the human body.


The synthetically produced form of Glucuronolactone is included in energy drinks and dietary supplements to improve overall athletic performance.
Glucuronolactone is a naturally occurring metabolite found in almost all connective tissues of the human body.
Glucuronolactone is produced from the breakdown of glucose in the liver and may be found in natural food and drinks such as red wine.


However, the quantities of Glucuronolactone obtained from natural sources are relatively low compared to that taken from energy drinks and dietary supplements.
Thus, to enjoy the benefits of Glucuronolactone, individuals are advised to take dietary supplements containing the compound.


Glucuronolactone is also called Glucuronic acid lactone, Glucurone, Glucurolactone, D-glucurono-gamma-lactone, and glucurono-γ-lactone.
Glucuronolactone's molecular formula is C6H8O6, and its CAS number is 32449-92-6.
The molecular weight of Glucuronolactone is 176.12 g/mol.


Glucuronolactone has a white powder appearance and is soluble in water.
During its metabolism, Glucuronolactone is broken down into glucaric acid, xylitol, and L-xylulose.
Studies reveal that Glucuronolactone may also play a vital role in synthesizing Ascorbic Acid or Vitamin C.


Glucuronolactone is a naturally occurring chemical compound produced by the metabolism of glucose in the human liver.
Glucuronolactone is an important structural component of nearly all connective tissues.
Glucuronolactone is also found in many plant gums.


Glucuronolactone is present in many energy drinks.
Most of these drinks also contain caffeine, but Glucuronolactone is included because it is purported to fight fatigue and provide a sense of well-being.
Glucuronolactone is a product obtained by the oxidation of glucose.


Glucuronolactone is also added to pre-workout products.
Glucuronolactone is a white crystalline powder.
Glucuronolactone is odourless, slightly bitter.


Glucuronolactone is a substance that is produced when glucose is converted in the liver.
Most typically found in sports performance enhancing or pre-workout products such as energy drinks.
Glucuronolactone is most likely liver protective and promote energy and endurance especially in combination with caffeine.


Glucuronolactone is a prodrug for the compound D-Glucaro-1,4-Lactone.
Glucuronolactone is a normal human metabolite formed from glucose.
Glucuronolactone is in equilibrium with its immediate precursor, glucuronic acid, at physiological pH.


Glucuronic acid is found in plants, mainly in gums.
However, it is combined with other carbohydrates in an aggregated form, so it is not easily bioavailable.
Glucuronic acid is an important component of all animal fibers and connective tissues.


Studies have shown that when humans take Glucuronolactone orally, it is rapidly absorbed, metabolized, and excreted in the form of glucaric acid, xylitol, and L-xylulose.
Human metabolic considerations suggest that the body may process small amounts of Glucuronolactone without problems.


However, Glucuronolactone intake from certain energy drinks may be two orders higher than other dietary sources.
The only study using chronic dosing was in rats, and rodents are known to metabolize Glucuronolactone differently than humans.
Glucuronolactone belongs to the class of organic compounds known as isosorbide.


These are organic polycyclic compounds containing an isosorbide(1,4-Dianhydrosorbitol) moiety, which consists of two -oxolan-3-ol rings.
Glucuronolactone belongs to the class of organic compounds known as isosorbide.
Glucuronolactone is a very mild and mentholic tasting compound.


Glucuronolactone is a naturally occurring substance that is an important structural component of nearly all connective tissues.
Glucuronolactone is also found in many plant gums. Glucuronolactone is a white solid odorless compound, soluble in hot and cold water.
Glucuronolactone's melting point ranges from 176 to 178 °C.


Glucuronolactone can exist in a monocyclic aldehyde form or in a bicyclic hemiacetal (lactol) form.
Glucuronolactone is a popular ingredient in energy drinks because it has been shown to be effective at increasing energy levels and improving alertness.
Glucuronolactone supplementation also significantly reduces "brain fog" cause by various medical conditions.


Although levels of Glucuronolactone in energy drinks can far exceed those found in the rest of the diet, it is extremely safe and well tolerated.
The European Food Safety Authority (EFSA) has concluded that exposure to Glucuronolactone from regular consumption of energy drinks is not a safety concern.
The no-observed-adverse-effect level of Glucuronolactone is 1000 mg/kg/day.


These are organic polycyclic compounds containing an isosorbide(1,4-Dianhydrosorbitol) moiety, which consists of two -oxolan-3-ol rings.
Glucuronolactone is an ingredient used in some energy drinks.
Although levels of Glucuronolactone in energy drinks can far exceed those found in the rest of the diet.


Research into Glucuronolactone is too limited to assert claims about its safety.
According to The Merck Index, Glucuronolactone is used as a detoxicant.
Glucuronolactone is also metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis.


Glucuronolactone is a chemical.
Glucuronolactone can be made by the body.
Glucuronolactone is also found in foods and made in laboratories.


Glucuronolactone is a molecule commonly found as a component of energy drink formulations with surprisingly minimal research on it, given its societal usage.
D-glucurono-6,3-lactone is a Glucuronolactone.


Glucuronolactone is functionally related to a D-glucuronic acid
Glucuronolactone is a natural product found in Arabidopsis thaliana, Homo sapiens, and other organisms with data available.
Glucuronolactone Powder contains no fillers.


Glucuronolactone is a well-known nootropic in a practical capsule from.
Glucuronolactone is produced by the metabolization of glucose in the liver and occurs naturally in the body.
Glucuronolactone is an important structural component of nearly all connective tissues.


When taken as a supplement, Glucuronolactone is used for improving alertness, avoiding mental fatigue, and may be beneficial in maintaining joint and tendon health.
Glucuronolactone is used in many energy products, including Mettle Energy Drink Powder, which uses 370mg per serving.
Consult a doctor regarding your particular usage and dose.


As a naturally occurring substance, Glucuronolactone is a key component of nearly all connective tissue.
In vitro, Dehydrogenase can metabolize Glucuronolactone to D-Glucaro-1,4-Lactone (G14L).
Glucuronolactone is present in many commercial products as a mixture of active ingredients.


Glucuronolactone is also found in complex supplements along with taurine and caffeine.
Glucuronolactone can also be layered with other pre-workout ingredients like creatine, beta-alanine, and citrulline.
Glucuronolactone is known for body energy and mental focus.
And Glucuronolactone is an ingredient in some concentrated pre-workout supplements, pre-workout supplements, and weight loss proteins.



USES and APPLICATIONS of GLUCURONOLACTONE:
Due to its ability to inhibit viral and bacterial beta-glucuronidase, Glucuronolactone has also been used to treat chronic carriers of typhoid bacteria.
Glucuronolactone is indicated that taking one to several grams per day will not cause problems.
Glucuronolactone is a well-know nootropic, which is used to support brain functions such as memory, thinking a concentration.


Glucuronolactone is naturally found in our body, as it is formed in the liver during glucose metabolism.
In addition, Glucuronolactone is also a part of all connective tissues.
Moreover, Glucuronolactone is also found in food in smaller quantities.


However, higher concentrations of this nootropic are usually added to energy drinks and supplements in order to improve sports and mental performance.
Additionally, according to The Merck Index, Glucuronolactone is used as a detoxicant.
The liver uses glucose to create Glucuronolactone, which inhibits the enzyme B-glucuronidase (metabolizes glucuronides), which should cause blood-glucuronide levels to rise.


Glucuronides combines with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine.
Higher blood-glucuronides help remove toxins from the body, leading to the claim that energy drinks are detoxifying.


Free glucuronic acid (or its self-ester Glucuronolactone) has less effect on detoxification than glucose, because the body synthesizes UDP-glucuronic acid from glucose.
Therefore, sufficient carbohydrate intake provides enough UDP-glucuronic acid for detoxication, and foods rich in glucose are usually abundant in developed nations.


Glucuronolactone is also metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use Glucuronolactone as a precursor for ascorbic acid synthesis.
Glucuronolactone is frequently used in energy drinks to increase energy levels and improve alertness, and can also be used to reduce "brain fog" caused by various medical conditions.


Glucuronolactone can be used to synthesize Vitamin C in creatures capable of this conversion, which are not humans.
Glucuronolactone is commonly used as an ingredient in "energy" drinks to increase attention and improve athletic performance, but there is no good scientific evidence to support its use.


Glucuronolactone is a naturally occurring substance that is an important structural component of nearly all connective tissues.
Glucuronolactone is sometimes used in energy drinks.
Unfounded claims that Glucuronolactone can be used to reduce "brain fog" are based on research conducted on energy drinks that contain other active ingredients that have been shown to improve cognitive function, such as caffeine.


Glucuronolactone is also found in many plant gums.
Glucuronolactone is a normal product of glucose breakdown in the liver.
All connective tissues contain Glucuronolactone, as well as many plant gums.


The amounts of Glucuronolactone found in food and those produced in the body, though, are negligible compared to the dosage in energy drinks and supplements.
As a supplement, Glucuronolactone’s available in the powder/capsule form.


Glucuronolactone is advertised as a supplement to enhance athletic performance, detoxify the liver, and reduce mental fatigue.
Glucuronolactone is a molecule commonly found as a component of energy drink formulations with surprisingly minimal research on it, given its societal usage.


Glucuronolactone is most often used to support brain functions such as memory, thinking, and concentration.
In addition, Glucuronolactone is a popular ingredient in energy drinks and nutritional supplements to improve sports performance.
That said, Glucuronolactone's effects will be appreciated not only by athletes, but also by students and people with physically or mentally demanding jobs.


Glucuronides combines with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine.
Glucuronolactone is available on a large scale and is intended for use in the chemical, diagnostic, pharmaceutical and related industries.


Glucuronolactone is used to help speed up recovery times after workouts, and to improve overall training performance levels
D-glucurono-gamma-lactone, also called Glucuronolactone, is a naturally occurring solid white compound used in sports and bodybuilding.
Therefore, Glucuronolactone in energy drinks is a common and main application.


Glucuronolactone can help enhance focus and improve athletic performance.
Glucuronolactone is frequently used in energy and alertness drinks.
Glucuronolactone is used Sport Nutrition, Diet Supplements, Pharmaceutical Field, Medical Usage.



PHYSICAL AND CHEMICAL PROPERTIES OFGLUCURONOLACTONE:
Glucuronolactone is a white solid odorless compound, soluble in hot and cold water. Its melting point ranges from 176 to 178 °C.
Glucuronolactone can exist in a monocyclic aldehyde form or in a bicyclic hemiacetal (lactol) form.



HISTORY OF GLUCURONOLACTONE:
It is unknown if Glucuronolactone is safe for human consumption due to a lack of proper human or animal trials. However, Glucuronolactone likely has limited effects on the human body.
Furthermore research on isolated supplements of Glucuronolactone is limited, no warnings appear on the Food and Drug Administration website regarding its potential to cause brain tumors or other maladies.



HOW DOES GLUCURONOLACTONE WORK?
There isn't enough information to know how Glucuronolactone might work as a medicine.



ALTERNATIVE PARENTS OF GLUCURONOLACTONE:
*Monosaccharides
*Gamma butyrolactones
*Tetrahydrofurans
*Secondary alcohols
*Hemiacetals
*Carboxylic acid esters
*Polyols
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF GLUCURONOLACTONE:
*Isosorbide
*Gamma butyrolactone
*Monosaccharide
*Tetrahydrofuran
*Carboxylic acid ester
*Hemiacetal
*Lactone
*Secondary alcohol
*Monocarboxylic acid or derivatives
*Polyol
*Carboxylic acid derivative
*Oxacycle
*Hydrocarbon derivative
*Carbonyl group
*Organic oxide
*Organic oxygen compound
*Alcohol
*Organooxygen compound
*Aliphatic heteropolycyclic compound



BENEFITS OF GLUCURONOLACTONE:
*a well-known nootropic,
*helps improve concentration and memory,
*one serving contains 500 mg of potassium Glucuronolactone,
*suitable for athletes, students, and people with mentally or physically demanding jobs,
*comes in a practical capsule form,
*suitable for vegans.



GLUCURONOLACTONE MARKET SIZE AND TREND:
The global Glucuronolactone market is worth $388.07 million in 2022, with a compound annual growth rate of 5.46% from 2022 to 2030, and is expected to reach $593.76 million by 2030.
North America has become the world’s largest Glucuronolactone market, accounting for 42.39% of market revenue in 2022.
The United States is the largest consumer country.

North America dominates the Glucuronolactone market as demand for energy drinks and nutritional supplements grows.
Additionally, the increasing geriatric population, desk-working lifestyle, rising food consumption, and rising awareness about the health benefits of antioxidants are helping to drive market growth in this region.

Glucuronolactone is available in liquid, powder, tablet, capsule, and other forms on the market.
In 2022, the Glucuronolactone in powder form market dominated, with the largest market share of 42.25%.
Glucuronolactone's market revenue is around $22.50 million.

This growth is attributed to the increasing health awareness among the public.
Furthermore, the liquidity segment is likely to dominate the market by 2030 due to rising disposable income.
In addition to energy drinks, Glucuronolactone is also involved in dietary supplements, pharmaceuticals, functional foods, cosmetics, and other fields.

In 2022, the pharmaceutical sector dominated the market, accounting for approximately 29.19% of global revenue.
This growth is attributed to the increasing use of Glucuronolactone-based tablets and supplements to treat arthritis, hepatitis, and cirrhosis.
The energy drinks market will likely dominate by 2030 owing to the emergence of multiple ingredients-constant players in the domestic and international industries.



INGREDIENTS OF GLUCURONOLACTONE:
Glucuronolactone, bulking agent (microcrystalline cellulose), anti-caking agent (magnesium stearate), hypromellose capsule.



STRUCTURE OF GLUCURONOLACTONE:
Glucuronolactone is a molecule that is commonly found in energy drinks (at around 10-60mg, with variance depending on brand), although in studies 'disassembling' the constituents of energy drinks suggest no significant contribution towards energy.



BIOLOGICAL SIGNIFICANCE OF GLUCURONOLACTONE:
In vitro, Glucuronolactone can be metabolized by a dehydrogenase into D-Glucaro-1,4-Lactone (G14L), where Glucuronolactone appears to metabolize into a dilactone (d-glucaro-1,4-3,6-dilactone) and then spontaneously degrade into G14L.



METABOLISM OF GLUCURONOLACTONE:
Glucuronolactone can be formed when glucuronic acid is degraded in subcritical water interchangeably.



GLUCURONOLACTONE IN ENERGY DRINKS:
IS GLUCURONOLACTONE SUITABLE?
WHY DO BRANDS LIKE TO ADD GLUCURONOLACTONE TO ENERGY DRINKS?
Glucuronolactone’s all up to its benefits.
Glucuronolactone has stimulant properties to help increase energy levels and combat fatigue.

Glucuronolactone enhances physical performance and improves mental alertness.
Some studies suggest that Glucuronolactone may have mood-enhancing effects.
Glucuronolactone is thought to increase dopamine levels in the brain, improving mood and overall well-being.

Glucuronolactone is involved in the body’s natural detoxification processes.
Glucuronolactone eliminates harmful substances, such as drugs, toxins, and pollutants, by aiding in forming glucuronide conjugates that can be easily excreted.

Glucuronolactone can protect the liver from damage caused by toxins and promote its overall function.
Glucuronolactone's antioxidant properties can help neutralize harmful free radicals in the body.

Glucuronolactone's cognitive-enhancing effects improve memory, focus, and concentration.
Because Glucuronolactone has properties of energy improvement, mood enhancement, etc.
Glucuronolactone is suitable in energy drinks.



GLUCURONOLACTONE IN ENERGY DRINKS: IS GLUCURONOLACTONE SAFE?
A submission from the Austrian National Food Authority included ingredient lists for 32 “energy drinks.”
This list is taken from the Austrian Market Beverage Review published in March 1996.
Not all “energy” drinks contain Glucuronolactone.

These drinks contain Glucuronolactone in a regulated concentration range of 2000-2400 mg/L.
Based on the average Austrian consumer’s per capita energy drink intake over a year, it can be estimated that the average daily intake of Glucuronolactone from an energy drink containing 2400 mg/l is 108 mg.

These estimates of energy drink intake can be compared with Glucuronolactone intake from other food sources.
However, only a few foods have been identified as containing Glucuronolactone.
In the United States, the average intake of Glucuronolactone from other food sources among people who eat foods containing Glucuronolactoneis 1.2 mg/day.

Wine is the richest source (up to 20 mg/L).
According to this US estimate, the average consumer consuming two 250 ml cans of energy drinks per day (containing 2400 mg/L) may consume 500 times more Glucuronolactone than other food sources.



WHAT ARE THE HEALTH BENEFITS OF USING GLUCURONOLACTONE?
Glucuronolactone may bring several health benefits to individual users, including the following.
Glucuronolactone may fight mental and physical fatigue.

Several studies show that Glucuronolactone supplementation may be beneficial in improving athletic performance and preventing exhaustion and fatigue following the performance of extraneous exercises.
It is also believed that Glucuronolactone may improve one’s ability to perform daily tasks and improve focus and attention.
Although it may improve energy levels, Glucuronolactone should not be used as a prime energy source.

*Glucuronolactone reduces brain fog.
Brain fogging is characterized by confusion and disorganized thoughts brought about by various factors, including stress.
According to some studies, Glucuronolactone may help reduce brain fog by improving overall mental health and cognitive function.
Some researches also show that persons who take Glucuronolactone have improved reaction time.

*Glucuronolactone supports joint health.
Glucuronolactone is also known to support the healing of joints, tendons, and ligaments following damage brought about by physical activity. It may also help strengthen bones and promote muscle development among bodybuilders.

*Other health benefits
Certain studies also show that Glucuronolactone supplementation may improve cardiovascular health.
Glucuronolactone also works to improve mood among depressive patients.



WHAT ARE THE BENEFITS OF GLUCURONOLACTONE?
Glucuronolactone is the γ‐lactone of glucuronic acid.
Glucuronolactone is a normal human metabolite and formed from glucose and glucuronic acid.
Glucuronolactone seems to be found naturally occurring substance produced in small amounts within the body.



STUDIES OF GLUCURONOLACTONE BENEFITS:
Uses of Glucuronolactone as an ingredient outside of the food and beverage industry includes as a performance enhancer and recovery aid.
Several studies have demonstrated that a pre-exercise, energy supplement (containing caffeine with taurine, Glucuronolactone, creatine, and amino acids) can delay fatigue and improve the quality of resistance exercise.
Taurine and Glucuronolactone are often combined with caffeine to form an ‘energy matrix’ in many energy drinks.



PURE POWDERED GLUCURONOLACTONE FORMS AND SPECIFICATIONS:
Glucuronolactone is available for dietary supplement formulations in powder with 99% purity.
It is important to purchase Glucuronolactone powder 99% only from legitimate suppliers to ensure the product is high quality.
Depending on the customer’s preference and suggestion, Glucuronolactone may be purchased in bulk or lesser quantities and packed in paper drums with two layers of polybags inside.

Glucuronolactone application is in energy drinks.
Some historians claim that the use of Glucuronolactone dates back to the early Vietnam War era when it was produced for use by soldiers. In the modern-day world, the compound is included in energy drinks as it is believed to increase energy levels, along with caffeine and taurine.

Along with caffeine and taurine, Glucuronolactone helps increase alertness and boost energy.
Glucuronolactone may also be taken in dietary supplement formulations to improve cognitive functions.

Glucuronolactone, Taurine, and Caffeine are the basic components of stimulant drinks.
Since stimulant drinks increase glucose levels, Glucuronolactone is believed that they may also increase insulin levels in response to hyperglycemia.
This is why the long-term intake of energy drinks in very high quantities is not recommended, as Glucuronolactone may pose risks to individual users.



HOW DOES GLUCURONOLACTONE WORK?
As a Detoxicant, experts say that Glucuronolactone works to help eliminate toxic compounds in body cells.
This is especially beneficial as Glucuronolactone may help prevent rapid cellular deterioration brought about by the accumulation of circulating free radicals.

Glucuronolactone may also help the liver cleanse the blood and eliminate unwanted toxins.
Also, as a component of connective tissues in the body, Glucuronolactone is believed to be important in repairing joints and muscle tears following strains.
Glucuronolactone is also important in producing Vitamin C, making it essential for improved immunity and overall body resistance.

Glucuronolactone in combination with caffeine, beta-alanine, creatine, citrulline and taurine has a possible positive effect in improving aerobic and anaerobic performance.
Glucuronolactone may also help to increase strength and help improve mental performance (reaction time, concentration and memory).



GLUCURONOLACTONE BENEFITS FOR MENTAL PERFORMANCE:
It has been reported that not only does Glucuronolactone help to improve physical performance, there is also evidence to suggests it helps to increase mental performance.
When given an energy drink containing Glucuronolactone, subjects showed significant improvements in reaction time, concentration, and memory.



RECOMMENDED DOSES OF GLUCURONOLACTONE:
Doses of 350mg Glucuronolactone have been found to be effective for use as a pre workout supplement.
The effects of Glucuronolactone set in fairly rapidly.

It has been reported that consuming a supplement containing Glucuronolactone 10 minutes before exercise resulted in improved exercise performance.
However, given that Glucuronolactone typically occurs with other ingredients, it is recommended for such supplements to be consumed 30 to 45 minutes before a workout, or as indicated by the manufacturer.



SUPPLEMENTS OF GLUCURONOLACTONE:
Since Glucuronolactone is known for physical energy and mental focus, it is an ingredient found in some pre workout supplements, concentrated pre workout supplements, and fat loss proteins.



WHERE DOES GLUCURONOLACTONE COME FROM?
Glucuronolactone naturally occurs in the connective tissue (eg tendons, ligaments, cartilage) of humans and animals, as well as in the gums of plants.
Glucuronolactone is also common ingredient in higher concentrations in energy drinks.



BENEFITS OF GLUCURONOLACTONE:
Glucuronolactone is present in many commercial products as a mixture of active ingredients.
These cocktails have been relatively well studied in relation to both physical and mental performance.

*Glucuronolactone Benefits for Bodybuilding & Endurance:
In physiological trials, Glucuronolactone has been shown to inhibit the synthesis of toxic by-products of intensive exercise as well as other negative effects causing fatigue.
Various studies have investigated products containing Glucuronolactone on physical performance.

When human subjects were given an energy drink containing a combination of Glucuronolactone, caffeine, and taurine, it was found that they experienced improvements in aerobic and anaerobic performance compared to those receiving a control.
When used in a pre workout supplement, Glucuronolactone in combination with the aforementioned ingredients resulted in an increase in total repetitions performed.

This also led to an increase in an anabolic response among supplemented people.
These results were later reproduced and supported by the same group of researchers.
Such results suggest that Glucuronolactone may help to increase strength and lean gains when used in conjunction with weight training.



PHYSICAL and CHEMICAL PROPERTIES of GLUCURONOLACTONE:
Molecular Weight: 176.12 g/mol
XLogP3-AA: -1.8
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 2
Exact Mass: 176.03208797 g/mol
Monoisotopic Mass: 176.03208797 g/mol
Topological Polar Surface Area: 104 Ų
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 202
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0

Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical formula: C6H8O6
Molar mass: 176.124 g·mol−1
Density: 1.76 g/cm3 (30 °C), 1.75 g/cm3 (25 °C)
Melting point: 176 to 178 °C (349 to 352 °F; 449 to 451 K), 172 - 175 °C
Solubility in water: 26.9 g/100 mL
CAS number: 32449-92-6
EC number: 251-053-3
Hill Formula: C₆H₈O���
HS Code: 2932 20 90
Chemical Formula: C6H8O6
Average Molecular Weight: 176.1241 g/mol
Monoisotopic Molecular Weight: 176.032087988 g/mol
IUPAC Name: (3R,3aR,5R,6R,6aR)-3,5,6-trihydroxy-hexahydrofuro[3,2-b]furan-2-one
Traditional Name: (3R,3aR,5R,6R,6aR)-3,5,6-trihydroxy-tetrahydro-3H-furo[3,2-b]furan-2-one

CAS Registry Number: 32449-92-6
SMILES: O[C@@H]1O[C@@H]2C@@HC(=O)O[C@@H]2[C@H]1O
InChI Identifier: InChI=1S/C6H8O6/c7-1-3-4(12-5(1)9)2(8)6(10)11-3/h1-5,7-9H/t1-,2-,3-,4-,5-/m1/s1
InChI Key: OGLCQHRZUSEXNB-WHDMSYDLSA-N
CAS Number: 32449-92-6
EC Number: 251-053-3
Formula Hill: C₆H₈O₆
Molar Mass: 176.12 g/mol
HS Code: 29322980
Classification: Superior
MDL Number: MFCD00135622
Chemical Formula: C6H8O6
Molecular Weight: 176.13 g/mol
SMILES: C(=O)C@@HO
Melting Point: 177.5 °C
Boiling Point: 403.5 °C
Flash Point: 174.9 °C



FIRST AID MEASURES of GLUCURONOLACTONE:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GLUCURONOLACTONE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GLUCURONOLACTONE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLUCURONOLACTONE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of GLUCURONOLACTONE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.



STABILITY and REACTIVITY of GLUCURONOLACTONE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


GLUCURONOLACTONE

Glucuronolactone is a naturally occurring chemical compound that belongs to the family of carbohydrates.
Glucuronolactone is derived from glucose and is structurally related to glucuronic acid, which is a component of many polysaccharides and proteoglycans in the body.

CAS Number: 32449-92-6
EC Number: 251-053-7

Synonyms: D-Glucurono-3,6-lactone, D-Glucuronic acid lactone, Glucuronic acid lactone, Glucurone, Glucurolactone, Glucuronosan, D-Glucuronolactone, Glucosiduronic acid lactone, Lactonized glucuronic acid, Glucurono-gamma-lactone, D-Glucuronic acid gamma-lactone, Glucuronic acid delta-lactone, D-Glucurono-gamma-lactone, Glucurono-gamma-lactone, D-Glucurono-3,6-lactone, Glucuronic acid delta-lactone



APPLICATIONS


Glucuronolactone is commonly used as an ingredient in energy drinks and dietary supplements to enhance alertness and physical performance.
Glucuronolactone is included in formulations aimed at promoting mental focus and concentration.

Glucuronolactone is utilized in sports nutrition products to support energy metabolism during exercise.
Glucuronolactone is often combined with caffeine and other stimulants to synergistically enhance cognitive and physical performance.

Glucuronolactone is found in pre-workout supplements for its potential to improve endurance and reduce fatigue.
Glucuronolactone is included in formulations targeting recovery after strenuous physical activity.
Glucuronolactone is used in cosmetics and skincare products for its hydrating and moisturizing properties.

Glucuronolactone is added to topical creams and lotions to help maintain skin hydration and elasticity.
In pharmaceuticals, it may be used as an excipient in drug formulations to improve solubility and bioavailability.

Glucuronolactone is studied for its potential antioxidant effects, which could contribute to overall health benefits.
Glucuronolactone is incorporated into detoxification programs and supplements aimed at supporting liver health.

Glucuronolactone is used in functional beverages and health drinks marketed for their detoxifying properties.
Glucuronolactone is researched for its role in combating oxidative stress and inflammation in the body.

In dietary supplements, it may be included to promote overall wellness and vitality.
Glucuronolactone is explored for its potential anti-inflammatory properties in various health conditions.
Glucuronolactone is included in oral health products for its potential benefits to gum health and oral hygiene.

Glucuronolactone is added to nutritional supplements aimed at supporting immune function and resilience.
Glucuronolactone is used in beauty supplements and ingestible skincare products for skin rejuvenation.

Glucuronolactone is investigated for its role in improving joint health and mobility.
Glucuronolactone is utilized in eye health supplements for its antioxidant and protective properties.
Glucuronolactone is included in dietary formulations targeting metabolic health and weight management.

Glucuronolactone is researched for its potential neuroprotective effects in neurological disorders.
Glucuronolactone is explored in anti-aging products for its ability to support cellular health.

Glucuronolactone is included in formulations aimed at promoting hair growth and scalp health.
Glucuronolactone serves a diverse range of applications across nutrition, cosmetics, pharmaceuticals, and health products, reflecting its broad potential benefits for human health and well-being.

Glucuronolactone is used in dietary supplements targeting cardiovascular health due to its potential to support healthy circulation.
Glucuronolactone is included in formulations aimed at enhancing the body's natural detoxification processes.

Glucuronolactone is explored for its potential to protect against oxidative damage caused by environmental stressors.
Glucuronolactone is added to energy bars and snacks for sustained energy release throughout the day.

Glucuronolactone is utilized in pet supplements for its potential benefits to animal health and vitality.
Glucuronolactone is included in functional foods and beverages for its ability to enhance nutritional value.

Glucuronolactone is researched for its role in improving gastrointestinal health and digestion.
Glucuronolactone is used in dietary aids targeting metabolism and energy balance.

Glucuronolactone is included in beauty drinks and collagen supplements for skin rejuvenation and elasticity.
Glucuronolactone is investigated for its potential to support bone health and mineral absorption.
Glucuronolactone is added to joint health supplements for its potential to maintain cartilage and joint function.

Glucuronolactone is explored in diabetic supplements for its role in glucose metabolism.
Glucuronolactone is utilized in wound healing formulations for its potential to support tissue repair.

Glucuronolactone is added to brain health supplements for its potential cognitive benefits.
Glucuronolactone is researched for its role in reducing the effects of hangovers and supporting liver recovery.

Glucuronolactone is used in cosmetic formulations targeting anti-aging and skin firming effects.
Glucuronolactone is explored in oral care products for its potential benefits to gum health and plaque reduction.

Glucuronolactone is included in eye health supplements for its potential to support vision and eye function.
Glucuronolactone is used in stress relief supplements for its potential calming and mood-balancing effects.
Glucuronolactone is researched in immune support supplements for its potential to strengthen immune responses.

Glucuronolactone is utilized in hair care products for its potential to improve hair strength and shine.
Glucuronolactone is explored for its potential anti-inflammatory effects in conditions like arthritis and joint pain.
Glucuronolactone is added to weight management supplements for its potential to support fat metabolism.

Glucuronolactone is used in detox foot patches and topical detox products for its potential to draw out toxins.
Glucuronolactone continues to be studied for its diverse applications across various health and wellness categories, highlighting its potential benefits in supporting overall health and vitality.

Glucuronolactone has been studied for its potential anti-inflammatory effects, though more research is needed.
In sports nutrition, it is used to enhance physical performance and recovery.
As a dietary supplement, glucuronolactone is often combined with other ingredients for synergistic effects.

Glucuronolactone is metabolized in the liver and readily enters systemic circulation to exert its physiological effects.
Glucuronolactone is utilized in pharmaceutical formulations for its role in drug metabolism and efficacy.
Glucuronolactone has a role in maintaining cellular integrity and function, particularly in detoxification pathways.

Glucuronolactone supports the body's natural ability to eliminate waste products and maintain homeostasis.
Glucuronolactone is considered a non-essential nutrient as the body can synthesize it from glucose.
Glucuronolactone has been explored for its potential benefits in improving skin health and appearance.

Glucuronolactone is included in dietary guidelines and regulations to ensure safe consumption levels.
Glucuronolactone serves as a multifaceted compound with diverse roles in metabolism, health, and nutrition.



DESCRIPTION


Glucuronolactone is a naturally occurring chemical compound that belongs to the family of carbohydrates.
Glucuronolactone is derived from glucose and is structurally related to glucuronic acid, which is a component of many polysaccharides and proteoglycans in the body.
Glucuronolactone is primarily known for its role as a precursor in the detoxification process in the liver, where it conjugates with various substances to facilitate their excretion in urine.

Glucuronolactone is a naturally occurring compound found in the body as a metabolite of glucose.
Glucuronolactone is a lactone form of glucuronic acid, with a chemical structure consisting of a six-membered ring.

Glucuronolactone is integral to the body's detoxification processes, aiding in the removal of harmful substances.
Glucuronolactone is known for its role in conjugating with toxins and drugs to facilitate their elimination via urine.

Glucuronolactone plays a crucial part in the formation of water-soluble glucuronides, which are more easily excreted from the body.
In dietary supplements and energy drinks, glucuronolactone is often touted for its potential to boost energy levels.

Glucuronolactone is believed to support mental alertness and cognitive function due to its involvement in energy metabolism.
Glucuronolactone is sometimes used in cosmetics for its hydrating properties, promoting skin moisture retention.
Chemically, it is classified as a carbohydrate and is closely related to glucuronic acid.

Glucuronolactone has antioxidant properties that may contribute to overall health and well-being.
Glucuronolactone is generally considered safe for consumption in regulated amounts in food and supplements.
Glucuronolactone has a mild, slightly sweet taste and is often added to beverages and nutritional products.

Research suggests that glucuronolactone may help support liver health by aiding in detoxification pathways.
Glucuronolactone is soluble in water, contributing to its bioavailability and effectiveness in physiological processes.



PROPERTIES


Physical Properties:

Appearance: White crystalline powder.
Odor: Odorless.
Taste: Slightly sweet.
Solubility: Soluble in water.
Melting Point: Approximately 176-178°C.
Density: Approximately 1.595 g/cm³.
Molecular Weight: Approximately 176.12 g/mol.
pH: Neutral (around pH 7) in aqueous solutions.
Crystallinity: Crystallizes in a monoclinic crystal system.
Hygroscopicity: Non-hygroscopic (does not absorb moisture from the air).


Chemical Properties:

Chemical Formula: C6H8O6.
Chemical Structure: Lactone form of D-glucuronic acid.
Functional Groups: Contains a lactone group (cyclic ester) and hydroxyl groups (-OH).
Acidity/Basicity: Slightly acidic.
Stability: Stable under normal storage conditions.
Reactivity: Non-reactive under normal conditions; does not undergo significant chemical reactions.
Optical Activity: Not optically active (racemic mixture).
Partition Coefficient (Log P): Not applicable as it is highly soluble in water.
Biodegradability: Generally considered biodegradable in natural environments.
Toxicity: Low acute toxicity; considered safe for consumption in regulated amounts.



FIRST AID


Inhalation:

If glucuronolactone dust or powder is inhaled, remove the affected person to fresh air immediately.
If breathing difficulties occur, provide oxygen if available and trained to do so.
Seek medical attention promptly if symptoms persist or worsen.


Skin Contact:

Remove any contaminated clothing or shoes immediately.
Wash the affected area thoroughly with soap and water for at least 15 minutes.
If irritation or redness develops, seek medical advice.
Clean contaminated clothing before reuse.


Eye Contact:

Immediately flush the eyes with gently flowing lukewarm water, holding the eyelids open.
Continue rinsing for at least 15 minutes, ensuring water reaches under the eyelids and over the entire eye surface.
Remove contact lenses if present and easy to do; continue rinsing.
Seek medical attention if irritation, pain, or redness persists.


Ingestion:

Rinse the mouth with water.
Do not induce vomiting unless directed by medical personnel.
If a large amount is swallowed or if symptoms such as nausea, vomiting, or abdominal pain occur, seek medical attention immediately.
Provide medical personnel with information about the product ingested and its container.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles or face shield, and protective clothing to minimize skin and eye contact.
Use respiratory protection (e.g., NIOSH-approved mask) if handling in dusty or aerosol-generating conditions.

Ventilation:
Use in a well-ventilated area to prevent the buildup of dust or vapors.
Ensure adequate ventilation during handling and storage.
Implement local exhaust ventilation if necessary to control airborne concentrations.

Avoidance of Contact:
Minimize direct skin contact and inhalation of dust or vapors.
Use tools or dispensing equipment to minimize exposure during handling.

Handling Procedures:
Handle glucuronolactone with care to prevent spills and minimize dust generation.
Do not eat, drink, or smoke while handling the substance.
Wash hands and any exposed skin thoroughly with soap and water after handling.

Static Electricity:
Ground equipment and containers to prevent static discharge, which could ignite dust or vapors.

Compatibility:
Ensure compatibility with other materials and chemicals used in formulations.
Follow compatibility guidelines provided by the manufacturer.

Spill and Leak Procedures:
Clean up spills immediately using appropriate absorbent materials.
Avoid generating dust.
Dispose of contaminated materials according to local regulations.

Emergency Procedures:
Familiarize personnel with emergency procedures, including evacuation routes and emergency contacts.
Have spill control measures and appropriate firefighting equipment readily available.


Storage:

Storage Conditions:
Store glucuronolactone in a cool, dry, well-ventilated area away from direct sunlight and sources of heat or ignition.
Maintain storage temperatures as recommended by the manufacturer to ensure product stability.

Temperature Control:

Store in a temperature-controlled environment to prevent degradation or changes in physical properties.

Separation:
Store away from incompatible materials such as strong oxidizers, acids, and bases.

Container Integrity:
Inspect containers regularly for leaks or damage.
Replace damaged containers to prevent spills and exposure.

Labeling:
Ensure containers are properly labeled with the product name, hazard information, handling precautions, and storage requirements.

Security Measures:
Restrict access to storage areas to authorized personnel only.
Store in locked cabinets or rooms if necessary.

Shelving and Stacking:
Store containers on shelves or pallets to prevent contact with the ground and facilitate inspection and handling.

Environmental Considerations:
Prevent spills from entering drains, waterways, or soil. Have containment measures in place to capture accidental releases.
GLUTAMIC ACID
Glutamic acid is one of the 20-22 proteinogenic amino acids, and its codons are GAA and GAG.
Glutamic acid is a non-essential amino acid.
The carboxylate anions and salts of Glutamic acid are known as glutamates.

CAS: 6899-05-4
MF: C5H9NO4
MW: 147.13

Glutamic acid is an optically active form of glutamic acid having L-configuration.
Glutamic acid has a role as a nutraceutical, a micronutrient, an Escherichia coli metabolite, a mouse metabolite, a ferroptosis inducer and a neurotransmitter.
Glutamic acid is a glutamine family amino acid, a proteinogenic amino acid, a glutamic acid and a L-alpha-amino acid.
Glutamic acid is a conjugate acid of a L-glutamate(1-).
Glutamic acid is an enantiomer of a D-glutamic acid.
Glutamic acid is an amino acid used to form proteins.
In the body, Glutamic acid turns into glutamate.
This is a chemical that helps nerve cells in the brain send and receive information from other cells.

Glutamic acid may be involved in learning and memory.
Glutamic acid may help people with hypochlorhydria (low stomach acid) or achlorhydria (no stomach acid).
In neuro science, Glutamic acid is an important neuro transmitter that plays a key role in long-term potentiation and is important for learning and memory.
Glutamic acid is an alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.
Glutamic acid has a role as a fundamental metabolite.
Glutamic acid is an alpha-amino acid and a polar amino acid.
Glutamic acid contains a 2-carboxyethyl group.
Glutamic acid is a conjugate acid of a glutamate(1-).

Glutamic acid is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins.
Glutamic acid is a non-essential nutrient for humans, meaning that the human body can synthesize enough for its use.
Glutamic acid is also the most abundant excitatory neurotransmitter in the vertebrate nervous system.
Glutamic acid serves as the precursor for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons.

Glutamic acid's molecular formula is C5H9NO4.
Glutamic acid exists in three optically isomeric forms; the dextrorotatory l-form is usually obtained by hydrolysis of gluten or from the waste waters of beet-sugar manufacture or by fermentation.
Glutamic acid's molecular structure could be idealized as HOOC−CH(NH2)−(CH2)2−COOH, with two carboxyl groups −COOH and one amino group −NH2.
However, in the solid state and mildly acidic water solutions, the molecule assumes an electrically neutral zwitterion structure −OOC−CH(NH+3)−(CH2)2−COOH.
Glutamic acid is encoded by the codons GAA or GAG.

The acid can lose one proton from its second carboxyl group to form the conjugate base, the singly-negative anion glutamate −OOC−CH(NH+3)−(CH2)2−COO−.
This form of the compound is prevalent in neutral solutions.
The glutamate neurotransmitter plays the principal role in neural activation.
This anion creates the savory umami flavor of foods and is found in glutamate flavorings such as MSG.
In Europe Glutamic acid is classified as food additive E620.
In highly alkaline solutions the doubly negative anion −OOC−CH(NH2)−(CH2)2−COO− prevails.
The radical corresponding to glutamate is called glutamyl.

Glutamic acid, also known as L-glutamic acid or as glutamate, the name of its anion, is an alpha-amino acid.
These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
Amino acids are organic compounds that contain amino (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
Glutamic acid is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins.
Glutamic acid is found in all organisms ranging from bacteria to plants to animals.

Glutamic acid is classified as an acidic, charged (at physiological pH), aliphatic amino acid. In humans Glutamic acid is a non-essential amino acid and can be synthesized via alanine or aspartic acid via alpha-ketoglutarate and the action of various transaminases.
Glutamic acid also plays an important role in the body's disposal of excess or waste nitrogen.
Glutamic acid undergoes deamination, an oxidative reaction catalysed by glutamate dehydrogenase leading to alpha-ketoglutarate.
In many respects Glutamic acid is a key molecule in cellular metabolism.
Glutamic acid is the most abundant fast excitatory neurotransmitter in the mammalian nervous system.
At chemical synapses, Glutamic acid is stored in vesicles.

Nerve impulses trigger release of Glutamic acid from the pre-synaptic cell.
In the opposing post-synaptic cell, glutamate receptors, such as the NMDA receptor, bind glutamate and are activated.
Because of its role in synaptic plasticity, Glutamic acid is believed that glutamic acid is involved in cognitive functions like learning and memory in the brain.
Glutamic acid transporters are found in neuronal and glial membranes.
They rapidly remove glutamate from the extracellular space.
In brain injury or disease, they can work in reverse and excess glutamate can accumulate outside cells.
This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity.

The mechanisms of cell death include: Damage to mitochondria from excessively high intracellular Ca2+. Glu/Ca2+-mediated promotion of transcription factors for pro-apoptotic genes, or downregulation of transcription factors for anti-apoptotic genes.
Excitotoxicity due to Glutamic acid occurs as part of the ischemic cascade and is associated with stroke and diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease.
Glutamic acid has been implicated in epileptic seizures.
Microinjection of Glutamic acid into neurons produces spontaneous depolarization around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks.
This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage activated calcium channels, leading to Glutamic acid release and further depolarization.

Glutamic acid was discovered in 1866 when it was extracted from wheat gluten (from where it got its name.
Glutamate has an important role as a food additive and food flavoring agent.
In 1908, Japanese researcher Kikunae Ikeda identified brown crystals left behind after the evaporation of a large amount of kombu broth (a Japanese soup) as glutamic acid.
These crystals, when tasted, reproduced a salty, savory flavor detected in many foods, most especially in seaweed.
Professor Ikeda termed this flavor umami.
He then patented a method of mass-producing a crystalline salt of glutamic acid, monosodium glutamate.

Chemical Properties
The side chain carboxylic acid functional group has a pKa of 4.1 and therefore exists almost entirely in its negatively charged deprotonated carboxylate form at pH values greater than 4.1; therefore, it is negatively charged at physiological pH ranging from 7.35 to 7.45.

Uses
Glutamic acid is a moisture binder and an anti-oxidant. glutamic acid is an amino acid manufactured by means of fermentation, generally from a vegetable protein.
Glutamic Acid is an amino acid that is a white crystalline powder of slight solubility in water.
Glutamic acid is monosodium glutamate (msg) which functions as a flavor enhancer in meats.
Glutamic acid also is a nutrient, dietary supplement, and salt substitute.

Metabolism
Glutamic acid is a key compound in cellular metabolism.
In humans, dietary proteins are broken down by digestion into amino acids, which serve as metabolic fuel for other functional roles in the body.
A key process in amino acid degradation is transamination, in which the amino group of an amino acid is transferred to an α-ketoacid, typically catalysed by a transaminase.

Neurotransmitter
Glutamic acid is the most abundant excitatory neurotransmitter in the vertebrate nervous system.
At chemical synapses, glutamate is stored in vesicles.
Nerve impulses trigger release of Glutamic acid from the pre-synaptic cell.
In the opposing post-synaptic cell, Glutamic acid receptors, such as the NMDA receptor, bind glutamate and are activated.
Because of its role in synaptic plasticity, glutamate is involved in cognitive functions like learning and memory in the brain.
The form of plasticity known as long-term potentiation takes place at glutamatergic synapses in the hippocampus, neocortex, and other parts of the brain.
Glutamic acid works not only as a point-to-point transmitter but also through spill-over synaptic crosstalk between synapses in which summation of glutamate released from a neighboring synapse creates extrasynaptic signaling / volume transmission.
Glutamic acid transporters are found in neuronal and glial membranes .
They rapidly remove glutamate from the extracellular space.
In brain injury or disease, they can work in reverse, and excess glutamate can accumulate outside cells.
This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity.

Brain nonsynaptic glutamatergic signaling circuits
Extracellular glutamate in Drosophila brains has been found to regulate postsynaptic glutamate receptor clustering, via a process involving receptor desensitization.
A gene expressed in glial cells actively transports glutamate into the extracellular space, while, in the nucleus accumbens-stimulating group II metabotropic glutamate receptors, this gene was found to reduce extracellular glutamate levels.
This raises the possibility that this extracellular glutamate plays an "endocrine-like" role as part of a larger homeostatic system.

Flavor enhancer
Glutamic acid, being a constituent of protein, is present in every food that contains protein, but it can only be tasted when Glutamic acid is present in an unbound form.
Significant amounts of free glutamic acid are present in a wide variety of foods, including cheese and soy sauce, and is responsible for umami, one of the five basic tastes of the human sense of taste.
Glutamic acid is often used as a food additive and flavour enhancer in the form of its salt, known as monosodium glutamate (MSG).

Nutrient
All meats, poultry, fish, eggs, dairy products, and kombu are excellent sources of glutamic acid.
Some protein-rich plant foods also serve as sources.
Thirty to 35 % of the protein in wheat is glutamic acid.
Ninety-five percent of the dietary glutamate is metabolized by intestinal cells in a first pass.

Plant growth
Auxigro is a plant growth preparation that contains 30 % glutamic acid.

NMR spectroscopy
In recent years, there has been much research into the use of RDCs in NMR spectroscopy.
A glutamic acid derivative, poly-γ- benzyl-L-glutamate (PBLG), is often used as an alignment medium to control the scale of the dipolar interactions observed.

Pharmacology
The drug phencyclidine (more commonly known as PCP) antagonizes glutamic acid non-competitively at the NMDA receptor.
For the same reasons, dextromethorphan and ketamine also have strong dissociative and hallucinogenic effects.
Glutamic acid does not easily pass the blood brain barrier, but , instead, is transported by a high-affinity transport system.
Glutamic acid can also be converted into glutamine.

Synonyms
L-glutamic acid
GLUTAMIC ACID
56-86-0
L-glutamate
(2S)-2-Aminopentanedioic acid
(S)-2-Aminopentanedioic acid
Glutamidex
Glutaminol
H-Glu-OH
glutacid
Aciglut
glutaminic acid
L-Glutaminic acid
Glutamicol
Glutaton
(S)-Glutamic acid
Glusate
L-glu
L-(+)-glutamic acid
D-Glutamiensuur
alpha-aminoglutaric acid
Glutamic acid, L-
Acidum glutamicum
(S)-(+)-Glutamic acid
Acide glutamique
2-Aminoglutaric acid
Acidum glutaminicum
L-2-Aminoglutaric acid
1-Aminopropane-1,3-dicarboxylic acid
25513-46-6
Acido glutamico
FEMA No. 3285
L-alpha-Aminoglutaric acid
Glutamic acid (H-3)
Glutamate, L-
alpha-Glutamic acid
glut
glutamate
Glutamic acid (VAN)
a-Glutamic acid
L-Glutaminsaeure
Glutamic acid, (S)-
Glutaminic acid (VAN)
CCRIS 7314
L-Acido glutamico
Pentanedioic acid, 2-amino-, (S)-
glu
a-Aminoglutaric acid
Glutamic Acid [USAN:INN]
AI3-18472
L-a-Aminoglutaric acid
Acide glutamique [INN-French]
Acido glutamico [INN-Spanish]
Acidum glutamicum [INN-Latin]
EPA Pesticide Chemical Code 374350
NSC 143503
alpha-Aminoglutaric acid (VAN)
Glutamic Acid (L-glutamic acid)
2-Aminopentanedioic acid, (S)-
aminoglutaric acid
EINECS 200-293-7
L-2-amino-pentanedioic acid
UNII-3KX376GY7L
3KX376GY7L
INS NO.620
DTXSID5020659
CHEBI:16015
Gamma-L-Glutamic Acid
INS-620
L-Glutamic acid (9CI)
C5H9NO4
NSC-143503
L(+)-Glutamic acid
E620
Glutamic acid, L-, peptides
DTXCID30659
HSDB 490
E 620
E-620
EC 200-293-7
Sodium Glutamate (L-glutamic Acid)
NCGC00024502-03
L-Glutamic acid (JAN)
(S)-2-AMINO-1,5-PENTANEDIOIC ACID
L-Glutamic acid-13C5
L-GLUTAMIC ACID [JAN]
Acido glutamico (INN-Spanish)
Acidum glutamicum (INN-Latin)
(2S)-2-aminopentanedioate
l glutamic acid
GLUTAMIC ACID (EP MONOGRAPH)
GLUTAMIC ACID [EP MONOGRAPH]
.alpha.-Glutamic acid
ALANINE IMPURITY B (EP IMPURITY)
ALANINE IMPURITY B [EP IMPURITY]
6899-05-4
glt
2-Amino-pentanedioic acid
LYSINE ACETATE IMPURITY B (EP IMPURITY)
LYSINE ACETATE IMPURITY B [EP IMPURITY]
1-amino-propane-1,3-dicarboxylic acid
GLUTAMIC ACID [USAN]
55443-55-5
MFCD00002634
aminoglutarate
Gulutamine
alpha-Glutamate
a-Glutamate
L-gluatmate
a-Aminoglutarate
L-glutamic-acid
NSC143503
L-Glutamic adid
2-Aminoglutarate
Glutamate, L
1ftj
1xff
(S)-glutamate
Glutamic acid, L
L-a-Aminoglutarate
alpha-Aminoglutarate
Gulutamine (USP)
(L)-glutamic acid
H-Glu
L-Glutamic,(S)
L-(+)-Glutamate
L-alpha-Aminoglutarate
Glutamic acid (USP)
Tocris-0218
[3h]-l-glutamic acid
1ii5
Polyglutamic acid(PGA)
(+)-L-Glutamic acid
(S)-(+)-Glutamate
(S)-Glu
L-[14C(U)]glutamate
(S)-2-Aminopentanedioate
Biomol-NT_000170
D00ENY
GLUTAMIC ACID [MI]
L-Glutamic acid (JP17)
SCHEMBL2202
GLUTAMIC ACID [INN]
L-Glutamic acid, 98.5%
Lopac0_000529
S)-2-Aminopentanedioic acid
GLUTAMIC ACID [INCI]
GLUTAMIC ACID [VANDF]
L-GLUTAMIC ACID [FCC]
BPBio1_001132
CHEMBL575060
GTPL1369
GLUTAMIC ACID [USP-RS]
GLUTAMIC ACID [WHO-DD]
L-GLUTAMIC ACID [FHFI]
L-Glutamic acid, 99%, FCC
BDBM17657
CHEBI:53374
Glutamic acid, L-(7CI,8CI)
1-Aminopropane-1,3-dicarboxylate
(C5-H9-N-O4)x-
Glutamic acid, L- (7CI,8CI)
L (+)-glutamic acid, alpha-form
1-amino-propane-1,3-dicarboxylate
138-16-9
L-Glutamic acid, non-animal source
Pentanedioic acid, 2-amino-, (S)
Tox21_113053
HB0383
HSCI1_000269
PDSP1_000128
PDSP1_001539
PDSP2_000127
PDSP2_001523
s6266
AKOS006238837
AKOS015854087
AM81690
CCG-204619
DB00142
LS-2330
SDCCGSBI-0050512.P002
CAS-56-86-0
NCGC00024502-01
NCGC00024502-02
NCGC00024502-04
NCGC00024502-07
(2S)-2-aminopentanedioic acid;H-Glu-OH
AC-11294
DS-13284
HY-14608
LS-71885
(S)-1-Aminopropane-1,3-dicarboxylic acid
(S)-1-Aminopropane-1,3-dicarboxylic acid
CS-0003473
G0059
EN300-52632
L-Glutamic acid, BioUltra, >=99.5% (NT)
L-Glutamic acid, tested according to Ph.Eur.
C00025
D00007
L-Glutamic acid, NIST(R)RM 8573, USGS40
M02979
M03872
Glutamic acid, L-; ((S)-(+)-Glutamic acid)
L-Glutamic acid, JIS special grade, >=99.0%
L-Glutamic acid, NIST(R) RM 8574, USGS41
A831210
Glutamic acid, L-; ((S)-(+)-Glutamic acid)
SR-01000597730
J-502415
L-Glutamic acid, ReagentPlus(R), >=99% (HPLC)
L-Glutamic acid, Vetec(TM) reagent grade, >=99%
SR-01000597730-1
L-Glutamic acid, >=99%, FCC, natural sourced, FG
Q26995161
F8889-8668
Z756440052
27322E29-9696-49C1-B541-86BEF72DE2F3
Glutamic acid, European Pharmacopoeia (EP) Reference Standard
L-Glutamic acid, certified reference material, TraceCERT(R)
Glutamic acid, United States Pharmacopeia (USP) Reference Standard
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
Glutaraldehyde
Glutaric acid dialdehyde; Glutardialdehyde; Glutaral; 1,3-Diformylpropane; 1,5-Pentanedial; 1,5-Pentanedione; Glutaric aldehyde; Glutarol; Gluteraldehyde; Pentanedial; Sonacide; Aldehyd glutarowy; Aldesan; Ucarcide CAS:111-30-8
GLUTARALDEHYDE
Glutaraldehyde is an organic compound with the formula (CH2)3(CHO)2.
The molecule consists of a five carbon chain doubly terminated with formyl (CHO) groups.
Glutaraldehyde is usually used as a solution in water, and such solutions exists as a collection of hydrates, cyclic derivatives, and condensation products, several of which interconvert.


CAS Number: 111-30-8
EC Number: 203-854-4
MDL Number: MFCD00007025
Chemical formula: C5H8O2 / OHC(CH2)3CHO


Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.
Glutaraldehyde has a role as a cross-linking reagent, a disinfectant and a fixative.
Glutaraldehyde solution is a light yellow liquid.
Glutaraldehyde mixes with water.


Glutaraldehyde, C5H8O2 or OCH(CH₂)₃CHO, is a transparent oily, liquid with a pungent odor.
Glutaraldehyde is a colorless liquid with a pungent odor used to sterilize medical and dental equipment.
Glutaraldehyde is an oily liquid at room temperature (density 1.06 g/mL), and miscible with water, alcohol, and benzene.
Monomeric glutaraldehyde can polymerize by aldol condensation reaction yielding alpha,beta-unsaturated poly-glutaraldehyde.


This reaction usually occurs at alkaline pH values.
Glutaraldehyde is colorless liquid with a pungent odor.
Glutaraldehyde is a clear, viscous colorless liquid.
Glutaraldehyde is a light yellow liquid.


Glutaraldehyde is commercially available in aqueous solutions ranging from 2-50%
Because the molecule has two carbonyl group is reactive to primary amine groups (even as its hydrates), Glutaraldehyde can function as a crosslinking agent for any substance with primary amine groups and develop imine connected links.
Glutaraldehyde is an organic compound with the formula (CH2)3(CHO)2.


The molecule consists of a five carbon chain doubly terminated with formyl (CHO) groups.
Glutaraldehyde is usually used as a solution in water, and such solutions exists as a collection of hydrates, cyclic derivatives, and condensation products, several of which interconvert.


Glutaraldehyde is a colorless, oily liquid with a sharp, pungent odor.
Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.
Glutaraldehyde has a role as a cross-linking reagent, a disinfectant and a fixative.
Glutaraldehyde solution is a light yellow liquid.


Glutaraldehyde mixes with water.
Glutaraldehyde is a common fixative in biology.
Fixation occurs by crosslinking (creating covalent chemical bonds between proteins in/on cells).
Glutaraldehyde is similar to another common cross-linking fixative, PFA.


1,5 Pentanedial, also known as Glutaraldehyde or glutaral is an organic compound with the formula OCH(CH2)3CHO.
Being non-volatile and bifunctional, Glutaraldehyde is often preferred to the less expensive formaldehyde.
Glutaraldehyde reacts with amines, amides, and thiol groups in proteins.
Glutaraldehyde, C5H8O2 or OCH(CH₂)₃CHO, is a transparent oily, liquid with a pungent odor.


Glutaraldehyde is an oily liquid at room temperature (density 1.06 g/mL), and miscible with water, alcohol, and benzene.
Glutaraldehyde is Colorless to yellowish liquid with a pungent fruity/medicinal odor.
Glutaraldehyde is a 5-25% aqueous solution.
Glutaraldehyde's Physical properties are based on a 25% solution.


Glutaraldehyde is miscible with water, ethanol, benzene, ether, acetone, dichloromethane, ethylacetate, isopropanol, n-hexane and toluene.
Glutaraldehyde is a slightly irritating odor of colorless or yellowish clear liquid, Glutaraldehyde is soluble in water and ether, ethanol and other organic solvents.


The free form of Glutaraldehyde in aqueous solution is not much, a large number of different forms of hydrate, and most of the ring structure of the hydrate form exists.
Glutaraldehyde is active in nature, easy to polymerize and oxidize, and will react with compounds containing active oxygen and nitrogen-containing compounds.


Because Glutaraldehyde has two carbonyl group is reactive to primary amine groups (even as its hydrates), Glutaraldehyde can function as a crosslinking agent for any substance with primary amine groups and develop imine connected link.
Colorless liquid with a pungent odor; Clear, viscous colorless liquid; Light yellow liquid; Colorless or light yellow liquid with a sharp pungent odor; Commercially available in aqueous solutions ranging from 2-50%


Glutaraldehyde is soluble in water and in organic solvents.
Solutions in water are stable for long periods of time.
Glutaraldehyde is colorless or yellowish clear and bright liquid with slight irritating smell, and can be dissolved in organic dissolvent such as water, ether and ethanol.


In water solution, Glutaraldehyde doesn't exist much in free state; instead, Glutaraldehyde makes appearance as hydrates with different forms and most of them are hydrates with annular structure.
Glutaraldehyde is reactive in property, and liable to polymerize and oxidize, which will react with compounds containing active oxygen and nitrogen.


The reaction of Glutaraldehyde with protein is mainly carried out between the carbonyl group of the former and the amino group of the latter.
Among the known aldehydes, Glutaraldehyde is one of the best cross-linking agents for proteins.
Glutaraldehyde has a small influence on the activity of enzyme, and most of enzymes can be fixed under controlled condition, to cross-link without losing their activity.


Contrbuting to its outstanding characteristics,Glutaraldehyde has drawn special concern from people and been put at broad application.
A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.
Glutaraldehyde is a colorless liquid with a pungent odor used to disinfect medical and dental equipment.
Glutaraldehyde is an oily liquid at room temperature (density 1.06 g/mL), and miscible with water, alcohol, and benzene.


Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2.
Glutaraldehyde consists of a five carbon chain doubly terminated with formyl (CHO) groups.
Glutaraldehyde is usually used as a solution in water, and such solutions exists as a collection of hydrates, cyclic derivatives, and condensation products, several of which interconvert.


Because Glutaraldehyde has two carbonyl group is reactive to primary amine groups (even as its hydrates), Glutaraldehyde can function as a crosslinking agent for any substance with primary amine groups and develop imine connected link.
Glutaraldehyde is an extremely versatile disinfectant and biological tissue fixer.
Also know by its IUPAC name Glutaraldehyde, Glutaraldehyde is a clear, pungent, and oily liquid that is miscible in water.


Glutaraldehyde is highly reactive with amines, amides, and thiols present in amino acid side chains, and most of its uses can be attributed to Glutaraldehyde's excellent protein crosslinking abilities.
Glutaraldehyde, an aliphatic dialdehyde, is a highly reactive compound that has been isolated as a water-soluble oil and usually is stored as an aqueous solution to inhibit polymerization.


Unbuffered aqueous solutions of Glutaraldehyde are stable for long periods of time, have a mildly acid pH, a negligible odor, and are not potently antimicrobial.
When buffered to an alkaline pH of 7.5 to 8.0 with sodium bicarbonate, the Glutaraldehyde is activated; Glutaraldehyde has a strong pungent odor, and Glutaraldehyde's antimicrobial activity is greatly enhanced for periods of up to 14 days
Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2.


Glutaraldehyde is colorless or yellowish clear and bright liquid with slight irritating smell, and can be dissolved in organic dissolvent such as water, ether and ethanol.
In water solution, Glutaraldehyde doesn't exist much in free state; instead,it makes appearance as hydrates with different forms.and most of them are hydrates with annular structure.


Glutaraldehyde is reactive in property, and liable to polymerize and oxidize, which will react with compounds containing active oxygen and nitrogen.
The reaction of Glutaraldehyde with protein is mainly carried out between the carbonyl group of the former and the amino group of the latter.
Among the known aldehydes, Glutaraldehyde is one of the best cross-linking agents for proteins.


Glutaraldehyde has a small influence on the activity of enzyme, and most of enzymes can be fixed under controlled condition, to cross-link without losing their activity.
Contrbuting to Glutaraldehyde's outstanding characteristics, Glutaraldehyde has drawn special concern from people and been put at broad application.


Glutaraldehyde, C5H8O2 or OCH(CH₂)₃CHO, is a transparent oily, liquid with a pungent odor.
Glutaraldehyde or Glutaric Aldehyde or 1,5-Pentanodione is a dialdehyde of low irritant power and strong action, of wide antimicrobial spectrum, that works due to Glutaraldehyde's oxidizing and breaking down action on the cell walls.



USES and APPLICATIONS of GLUTARALDEHYDE:
Crosslinking rigidifies and deactivates many biological functions, so in this way, Glutaraldehydesolutions are used as biocides and as fixative.
As a disinfectant, Glutaraldehyde is used to sterilize surgical instruments.
Glutaraldehyde is used as a cross-linking agent for gelatin, poly(vinyl alcohol) and polyheptapeptides.
Glutaraldehyde is also used as a fixative for electron microscopy and as disinfectants.


Glutaraldehyde provides water resistance to protein and polyhydroxy compounds by reacting through cross linking.
Glutaraldehyde acts as an intermediate for the production of resins, dyestuffs, pharmaceuticals, photographic films and for stabilization of proteins on agarose beads, activation of polystyrene and glass for immobilization of antibodies and antigens and coupling peptides onto carrier proteins.


Glutaraldehyde is a preservative with biological spectrum including gram +/- bacteria – aerobic, anaerobic and sulfate-reducing, yeast and some fungi.
Glutaraldehyde is used in shampoo, conditioner, shower gel, liquid soap and raw materials.
Glutaraldehyde offers characteristics such as no formaldehyde and high salt tolerance.


Glutaraldehyde offers compatibility with charged-, uncharged surfactants and other preservatives.
Glutaraldehyde is also used for industrial water treatment and as a chemical preservative.
Glutaraldehyde solution, 25% in water, is primarily for use as a protein cross-linking agent.
In the laboratory, glutaraldehyde solution is commonly used as an amine-reactive homobifunctional crosslinker and as a disinfectant for medical equipment.


Glutaraldehyde may effectively crosslink amine and hydrazine derivatives to proteins and other amine-containing polymers; biotin hydrazides have been directly coupled to nucleic acids with glutaraldehyde in a reaction that is potentially useful for conjugating fluorescent hydrazides and hydroxylamines to DNA.


Glutaraldehyde is a colorless, oily liquid with a sharp, pungent odor.
Glutaraldehyde is used for industrial, laboratory, agricultural, medical, and some household purposes, primarily for disinfecting and sterilization of surfaces and equipment.
For example, Glutaraldehyde is used in oil and gas recovery operations and pipelines, waste water treatment, x-ray processing, embalming fluid, leather tanning, paper industry, in fogging and cleaning of poultry houses, and as a chemical intermediate in the production of various materials.


Glutaraldehyde may be used in select goods, such as paint and laundry detergent.
Glutaraldehyde is used as a tissue fixative in electron microscopy.
Glutaraldehyde is employed as an embalming fluid, is a component of leather tanning solutions, and occurs as an intermediate in the production of certain industrial chemicals.


Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker.
The oligomeric state of proteins can be examined through this application.
A glutaraldehyde solution of 0.1% to 1.0% concentration may be used for system disinfection and as a preservative for long term storage.
Glutaraldehyde is used in biological electron microscopy as a fixative.


Glutaraldehyde kills cells quickly by crosslinking their proteins and is usually employed alone or mixed with formaldehyde as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells.
A second fixative procedure uses osmium tetroxide to crosslink and stabilise cell and organelle membrane lipids.
Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedment in an epoxy resin or acrylic resin.


Glutaraldehyde is also used in SDS-PAGE to fix proteins and peptides prior to staining.
Typically, a gel is treated with a 5% solution for approximately one half hour, after which Glutaraldehyde must be thoroughly washed to remove the yellow stain brought about by reacting with free tris.
Glutaraldehyde has been a high-level disinfectant for over 50 years.


As a disinfectant, Glutaraldehyde is used to eliminate harmful microorganisms on surgical instruments and has other uses as a fixative or preservative in other parts of a healthcare facility.
Glutaraldehyde is used in hospitals and medical and dental offices in solutions for cold sterilization and automatic processing of x-rays.
Glutaraldehyde is used as a tissue fixative in histology and microscopy, chemical intermediate, embalming fluid, biocide (cosmetics, water treatment, oilfield, and fish farming applications), disinfectant, cross-linking agent, leather tanning agent, gelatine hardening agent, and keratolytic.


Glutaraldehyde is used as an antimicrobial agent in agricultural, food handling, commercial, industrial, residential, public, and medical environments.
Glutaraldehyde is also used as materials preservative (cleansers, adhesives, paper, water based coatings, latex paints, inks, dyes, concrete admixtures, and reverse osmosis membranes) and in industrial processes and water systems treatment (recirculating and waste-water water systems, drilling muds, oil and gas storage systems, paper mills, and metalworking fluids).


Glutaraldehyde is used in a variety of applications, including disinfection and sanitization.
Glutaraldehyde-containing formulations address the needs of a variety of industries due to its strong efficacy across a broad pH range.
Crosslinking rigidifies and deactivates many biological functions, so in this way, Glutaraldehyde solutions are used as biocides and as fixative.


As a disinfectant, Glutaraldehyde is used to sterilize surgical instruments.
Glutaraldehyde is used as Disinfectant for surgical instruments that cannot be heat sterilized
Glutaraldehyde is used as A cross-linking and tanning agent
Glutaraldehyde is used as A biocide in metalworking fluids and in oil and gas pipelines


Glutaraldehyde is used as An antimicrobial in water-treatment systems
Glutaraldehyde is used as A slimicide in paper manufacturing
Glutaraldehyde is used as A preservative in cosmetics
Glutaraldehyde is used as A disinfectant in animal housing


Glutaraldehyde is used as A tissue fixative in histology and pathology labs
Glutaraldehyde is used as A hardening agent in the development of X-rays
Glutaraldehyde is used as In embalming solutions
Glutaraldehyde is used as In the preparation of grafts and bioprostheses


Glutaraldehyde is used as In various clinical applications
Glutaraldehyde may be used in select goods, such as paint and laundry detergent.
A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids.
Glutaraldehyde also used for undersea pipes to protect against corrosion.


Another application for treatment of proteins with Glutaraldehyde is the inactivation of bacterial toxins to generate toxoid vaccines.
Glutaraldehyde is also used in the treatment of hyperhidrosis under the control of dermatologists.
In people who have frequent sweating but do not respond to aluminum chloride.


Glutaraldehyde solution is an effective agent to treat palmar and plantar hyperhidrosis as an alternative to tannic acid and formaldehyde.
Veterinary uses: Glutaraldehyde diluted with water is often sold as alternative to carbon dioxide gas injection for aquarium plants.
Glutaraldehyde is commonly also used by aquarists in low doses as an algaecide.
Glutaraldehyde is used to disinfect medical and dental equipment.


Glutaraldehyde is also used for industrial water treatment and as a preservative.
Glutaraldehyde is used to reduce degradation in cells, tissues, and entire organisms before further experiments like electron microscopy.
Glutaraldehyde is used to fix specimen before electron microscopy where Glutaraldehyde is employed alone or mixed with polymethanal (paraformaldehyde) as the first of 2 fixations followed by osmium tetroxide.


Glutaraldehyde is used as an amine cross-linker.
Glutaraldehyde is used in SDS-PAGE to fix/crosslink proteins and peptides prior to staining.
Gels are treated with a 5% solution for ~30 min, after which it must be thoroughly washed to remove the yellow stain brought about by reacting with free Tris.


Alternatively, gels can be washed before fixation.
Glutaraldehyde is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
At room temperature Glutaraldehyde is a pungent colourless oily liquid and is mainly available as an aqueous solution of 50% concentration.
A Glutaraldehyde solution of 0.1% to 1.0% concentration may be used as a biocide for system disinfection and as a preservative for long term storage.


Glutaraldehyde is a sterilant, killing endospores in addition to many microorganisms and viruses.
Glutaraldehyde is also used for industrial water treatment and as a chemical preservative.
Glutaraldehyde is a colorless liquid with a pungent odor used to sterilize medical and dental equipment.
Glutaraldehyde is used as a tissue fixative in electron microscopy.


Glutaraldehyde is employed as an embalming fluid, is a component of leather tanning solutions, and occurs as an intermediate in the production of certain industrial chemicals.
Glutaraldehyde is also used for industrial water treatment and as a chemical preservative.
Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker.


The oligomeric state of proteins can be examined through this application.
Monomeric Glutaraldehyde can polymerize by aldol condensation reaction yielding alpha,beta-unsaturated poly-Glutaraldehyde.
This reaction usually occurs at alkaline pH values.
A Glutaraldehyde solution of 0.1% to 1.0% concentration may be used for system disinfection and as a preservative for long term storage.


Glutaraldehyde is used in biological electron microscopy as a fixative.
Glutaraldehyde kills cells quickly by crosslinking their proteins and is usually employed alone or mixed with formaldehyde as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells.
A second fixative procedure uses osmium tetroxide to crosslink and stabilise cell and organelle membrane lipids.


Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedment in an epoxy resin or acrylic resin.
Glutaraldehyde is also used in SDS-PAGE to fix proteins and peptides prior to staining.
Typically, a gel is treated with a 5% solution for approximately one half hour, after which it must be thoroughly washed to remove the yellow stain brought about by reacting with free tris.


Glutaraldehyde is claimed that it provides a bioavailable source of carbon for higher plants that is not available to algae.
Glutaraldehyde is used for cross-linking proteins and polyhydroxy materials.
Also Glutaraldehyde is used as a fixative for tissues and as an amine-reactive homobifunctional crosslinker.


Glutaraldehyde is also used in coupling reaction of biotin hydrazides to nucleic acids which is useful for conjugating fluorescent hydrazides and hydroxylamines to DNA and for stabilization ofproteins on agarose beads,activation of polystyrene and glass, for immobilization of antibodies and antigens.
Glutaraldehyde is a disinfectant, which is rapidly effective against vegetative forms of Gram-positiveand Gram-negative bacteria.


Glutaraldehyde is used in hospitals and medical and dental offices in solutions for cold sterilization and automatic processing of x-rays.
Glutaraldehyde is used as a tissue fixative in histology and microscopy, chemical intermediate, embalming fluid, biocide (cosmetics, water treatment, oilfield, and fish farming applications), disinfectant, cross-linking agent, leather tanning agent, gelatine hardening agent, and keratolytic.


Glutaraldehyde is used as an antimicrobial agent in agricultural, food handling, commercial, industrial, residential, public, and medical environments.
Glutaraldehyde is used as a fungicide, also used for leather tanning.


Also Glutaraldehyde is used as materials preservative (cleansers, adhesives, paper, water based coatings, latex paints, inks, dyes, concrete admixtures, and reverse osmosis membranes) and in industrial processes and water systems treatment (recirculating and waste-water water systems, drilling muds, oil and gas storage systems, paper mills, and metalworking fluids).
The largest single use of Glutaraldehyde is as an antimicrobial, bactericide, fungicide and a virucide.


Glutaraldehyde is used to sterilize hospital and veterinary equipment, and to disinfect surfaces in hospitals, veterinary hospitals, nursing homes, and food processing plants.
Glutaraldehyde is used to prevent bacterial growth in water supplies for washing air, cooler systems, logging ponds, and pulp and paper water systems.


Smaller uses are as an embalming fluid, as a fixative for tissues, for film processing and leather tanning.
Glutaraldehyde is used as bactericide, disinfector, tanning agent, widely used in petroleum development, leather treatment, food, plastics, coatings etc.


Glutaraldehyde is used as a disinfectant, as an intermediate in classical synthesis of pseudopelleterine, as a tanning agent in leather, and in the sterilization of endoscopic instruments, dental and barber equipment, thermometers, rubber or plastic equipment which cannot be heat sterilized.
Glutaraldehyde is used also as embalming fluid, in electron microscopy. Hardener for photographic gelatin.


Glutaraldehyde, Pharmacological agent used for hyperhidrosis and antifungal purposes and for treatment of warts and some bullous diseases as well as herpes infections.
Glutaraldehyde contains 5% sorbitan sesquioleate as emulsifier.
Glutaraldehyde is used as an antimicrobial agent in sugar mills and as a fixing agent in the immobilisation of glucose isomerase enzyme preparations for use in the manufacture of high fructose corn syrup.


Glutaraldehyde is also used for industrial water treatment and as a chemical preservative.
Glutaraldehyde is used as a disinfectant, Glutaraldehyde is used to sterilize surgical instruments.
Glutaraldehyde known as polycycloglutaracetal used as a fertilizer for aquatic plants.


It is claimed that Glutaraldehyde provides a bioavailable source of carbon for higher plants that is not available to algae.
Though not marketed as such due to federal regulations, the biocidal effect of Glutaraldehyde kills most algae at concentrations of 0.5 - 5.0 ppm.
These levels are not harmful to most aquatic fauna and flora.


Adverse reactions have been observed by some aquarists at these concentrations in some aquatic mosses, liverworts, and vascular plants.
Glutaraldehyde is also used for industrial water treatment and as a chemical preservative.
Glutaraldehyde is used as a tissue fixative in electron microscopy.
Glutaraldehyde is used as bactericide, disinfector, tanning agent, widely used in petroleum development, leather treatment, food, plastics, coatings etc.


Glutaraldehyde is also employed as an embalming fluid, is a component of leather tanning solutions, and occurs as an intermediate in the production of certain industrial chemicals.
Crosslinking rigidifies and deactivates many biological functions, so in this way, Glutaraldehyde solutions are used as biocides and as fixative.


Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker.
The oligomeric state of proteins can be examined through this application.
A pungent colorless oily liquid, Glutaraldehyde is used to disinfect medical and dental equipment.
Glutaraldehyde is commonly also used by aquarists in low doses as an algaecide.


Glutaraldehyde is applied as a disinfectant for heat-sensitive medical and dental equipment.
Glutaraldehyde’s biocidal properties are also utilized for industrial water treatment, hydraulic fracking, and as a topical wart treatment.
Glutaraldehyde is a preferred fixing agent for biological tissues, since it is nonvolatile, and is widely used for leather tanning, embalming, creation of toxoid vaccines, or preparing cell specimens for electron microscopy.


Glutaraldehyde is also used to fix certain enzymes during the production of high fructose corn syrup.
Glutaraldehyde is widely used in embalming; in the manufacture of adhesives, sealants, and electrical products; as a cross-linking agent for proteins and polyhydroxy compounds; in microcapsules containing flavoring agents; and as a tissue fixative in electron microscopy, the paper and leather tanning industries, and x-ray film developing solutions.


Glutaraldehyde is also used as a sterilizing agent for plastics, rubber, thermometers, lenses, and other surgical, dental, and hospital equipment.
Glutaraldehyde is an effective sporicidal agent, requiring about 3 h for an almost complete kill of spores as well as gram-negative and gram-positive bacteria, fungi, and viruses.


Glutaraldehyde has been used in surgical procedures including colonic anastomoses and dental pulpotomies.
Glutaraldehyde solutions (5-25%) are used clinically to treat skin disorders, including warts, hyperhidrosis (excessive sweating of the hands or soles of the feet), herpes simplex, and herpes zoster, and in the preparation of grafts and bioprostheses.


The preservative and antimicrobial properties of Glutaraldehyde have found broad application in cosmetic, toiletry, and chemical specialty products because of Glutaraldehyde's water solubility and usefulness in systems containing secondary or tertiary amines, quaternary ammonium compounds, or protonated amines.
Glutaraldehyde solutions often are used as cell and tissue fixatives in biochemical experiments during space-shuttle flights.


Glutaraldehyde diluted with water is often sold as alternative to carbon dioxide gas injection for aquarium plants.
A pungent colorless oily liquid, Glutaraldehyde is used to sterilise medical and dental equipment.
Glutaraldehyde, 2%, solution is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy.


Glutaraldehyde is a disinfectant, medication, preservative, and fixative.
Glutaraldehyde is widely used for oil production, medical care, bio-chemical, leather treatment, tanning agents, protein cross-linking agent; in the preparation of heterocyclic compounds; also used for plastics, adhesives, fuels, perfumes, textile, paper making, printing; corrosion prevention of instruments and cosmetics etc.


Glutaraldehyde is used as Disinfectant for surgical instruments that cannot be heat sterilized
Glutaraldehyde is used as A cross-linking and tanning agent
Glutaraldehyde is used as A biocide in metalworking fluids and in oil and gas pipelines
Glutaraldehyde is used as An antimicrobial in water-treatment systems


Glutaraldehyde is used as A slimicide in paper manufacturing
Glutaraldehyde is used as A preservative in cosmetics
Glutaraldehyde is used as A disinfectant in animal housing
Glutaraldehyde is used as A tissue fixative in histology and pathology labs


Glutaraldehyde is used as A hardening agent in the development of X-rays
Glutaraldehyde is used as In embalming solutions
Glutaraldehyde is used as In the preparation of grafts and bioprostheses
Glutaraldehyde is used as In various clinical applications


Glutaraldehyde is used as Disinfectant, biocide, tissue fixative, medicine (wart treatment); component of hydraulic fracturing (fracking) fluid.
Glutaraldehyde is used as a medication, preservative, disinfectant and fixative.
Glutaraldehyde is used to disinfect the surgical instruments as well as other items of hospitals.
Glutaraldehyde which is also utilized as a cold sterilant that can disinfect as well as clean heat-sensitive medical, dental and surgical equipment.


Glutaraldehyde is used for the sectors of chemical Processing, Gas and Oil.
Glutaraldehyde is a sort of corrosion inhibitor that can be used in several industrial and processing applications.
A pungent colorless oily liquid, Glutaraldehyde from our end is used to sterilize medical and dental equipment.
Glutaraldehyde is also used for industrial water treatment and as a preservative.


The use of Glutaraldehyde is particularly recommended in the Biosafety Ruls of the National Health Department and in almost all the Reglamentations on the subject in the work.
Glutaraldehyde is also recommended by almost all the manufacturers of endoscopic instruments, for their disinfection of high level and/or sterilization.


In neutral or slightly alkaline environments, this product develops its peak of efficacy, killing Gram + bacteria, Gram - bacteria, fungus, lipophilic virus, microbacteria, and even bacterial spores.
Moreover, when the product is activated, the medium and the stabilizing and oxidizing additives of it, provides the product longer shelf life to surgical instruments in general, prevents drying and cracking of plastic and rubber materials, as well as the corrosion of the low quality stainless steel materials.


Glutaraldehyde is a potent antimicrobial/sterilant used to disinfect equipment, surfaces, and laundry in the health care and cosmetology industries.
Glutaraldehyde is used in leather treatments, chemical syntheses, x-ray film developers, paper manufacture and paper finishes, and as a preservative in paints and art paints.


Glutaraldehyde is used as an embalming fluid and in many biochemical applications such as tissue fixative in electron microscopy and as an aminereactive homobifunctional crosslinker.
Glutaraldehyde is mainly used in the high performance disinfection and/or sterilization of elements that cannot be disinfected and/or sterilized through conventional ways (vapor, dry heat, radiation, etc.).


-Application Areas of Glutaraldehyde:
*Disinfectant Chemical
*Water Treatment Chemical
*Pharmaceutical Chemical
*Biocides


-Biochemistry:
Glutaraldehyde is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative.
Glutaraldehyde kills cells quickly by crosslinking their proteins.
Glutaraldehyde is usually employed alone or mixed with formaldehyde as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells.


-Glutaraldehyde is used for industrial, laboratory, agricultural, medical, and some household purposes, primarily for disinfecting and sterilization of surfaces and equipment.
For example, Glutaraldehyde is used in oil and gas recovery operations and pipelines, waste water treatment, x-ray processing, embalming fluid, leather tanning, paper industry, in fogging and cleaning of poultry houses, and as a chemical intermediate in the production of various materials.


-Material Science:
In material science Glutaraldehyde application areas vary from polymers to metals and biomaterials.
Glutaraldehyde commonly used as fixing agent before characterization of biomaterials for microscopy.
Glutaraldehyde is a powerfull crosslinking agent for many polymers contain primer amine groups.
Crosslinking with Glutaraldehyde can be used for a polymeric mixture or also can we used as interlinking agent between two different polymeric layers, and an interlinking agent to improve the adhesion force between two polymeric coatings.


-Dermatological uses of Glutaraldehyde:
As a medication Glutaraldehyde is used to treat plantar warts.
For this purpose, a 10% w/v solution is used.
Glutaraldehyde dries the skin, facilitating physical removal of the wart.


-Medical:
*Clinical uses:
Glutaraldehyde is used as a disinfectant and medication.
Usually applied as a solution, Glutaraldehyde is used to sterilize surgical instruments and other areas.


-Biochemistry:
Glutaraldehyde is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative.
Glutaraldehyde kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells.
A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids.


-Material Science:
In material science glutaraldehyde application areas range from polymers to metals and biomaterials.
Glutaraldehyde is commonly used as fixing agent before characterization of biomaterials for microscopy.
Glutaraldehyde is a powerful crosslinking agent for many polymers containing primer amine groups.
Glutaraldehdye also can be used for an interlinking agent to improve the adhesion force between two polymeric coatings.
Glutaraldehyde is also used to protect against corrosion of undersea pipes.


-Clinical uses of Glutaraldehyde:
Glutaraldehyde is used as a disinfectant and medication.
Applied as a solution, Glutaraldehyde is used to sterilize surgical instruments and other areas.


-Dermatological uses of Glutaraldehyde:
As a medication Glutaraldehyde is used to treat plantar warts.
For this purpose, a 10% w/v solution is used.
Glutaraldehyde dries the skin, facilitating physical removal of the wart.
Glutaraldehyde is also used in the treatment of hyperhidrosis under the control of dermatologists.
In people who have frequent sweating but do not respond to aluminum chloride.
Glutaraldehyde solution is an effective agent to treat palmar and plantar hyperhidrosis as an alternative to tannic acid and formaldehyde.


-Use in the Aquarium Hobby:
Glutaraldehyde diluted with water is often sold as alternative to carbon dioxide gas injection for aquarium plants.
Glutaraldehyde is commonly also used by aquarists in low doses as an algaecide.


-Glutaraldehyde is used in the health care field as a chemical disinfectant, and, in x-ray film processing.
Of special interest are the areas where it is used as:
*an ingredient in X-ray developers,
*a tissue fixative in the biochemistry of cells and electron microscopy, and an embalming agent.
*Alkaline glutaraldehyde is widely used in cold sterilization of medical, surgical and dental equipment.


-Glutaraldehyde is used for a number of applications:
*Disinfectant for surgical instruments that cannot be heat sterilized
*A cross-linking and tanning agent
*A biocide in metalworking fluids and in oil and gas pipelines
*An antimicrobial in water-treatment systems
*A slimicide in paper manufacturing
*A preservative in cosmetics
*A disinfectant in animal housing
*A tissue fixative in histology and pathology labs
*A hardening agent in the development of X-rays
*In embalming solutions
*In the preparation of grafts and bioprostheses
*In various clinical applications


-How is Glutaraldehyde Used in Healthcare Facilities?
Glutaraldehyde is used as a cold sterilant to disinfect a variety of heat-sensitive instruments, such as endoscopes, dialysis equipment, and more.
Glutaraldehyde is used as a high-level disinfectant for those surgical instruments that cannot be heat sterilized.


-Glutaraldehyde is used for several applications in healthcare facilities:
*Disinfectant and sterilization of surfaces and equipment
*A tissue fixative in pathology labs
*A hardening agent used to develop X-rays
*For the preparation of grafts



PROPERTIES of GLUTARALDEHYDE:
-Glutaraldehyde is a potent, cross-linking fixative
-bridges larger distances than PFA
-crosslinks are irreversible unlike those of PFA
-larger molecule than methanal from PFA & therefore slower
-penetration into tissue
-causes more autofluorescence than PFA.



PRODUCTION AND REACTIONS of GLUTARALDEHYDE:
PRODUCTION:
Glutaraldehydeis produced industrially by the catalytic oxidation of cyclopentene by hydrogen peroxide, which can be achieved in the presence of various tungstic acid-based heteropoly acid catalysts.
This reaction essentially mimics ozonolysis.
Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.


REACTIONS:
Like other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), Glutaraldehyde hydrates in aqueous solution, forming gem-diols.
These diols in turn equilibrate with cyclic hemiacetal.
Monomeric Glutaraldehyde polymerizes by aldol condensation and Michael reactions yielding alpha, beta-unsaturated poly-Glutaraldehyde and related oligomers.
This reaction occurs at alkaline pH values.

A number of mechanisms have been invoked to explain the biocidal and fixative properties of Glutaraldehyde.
Like many other aldehydes, Glutaraldehyde reacts with primary amines and thiol groups, which are common functional groups in proteins, nucleic acids and polymeric materials.
Being bi-functional, Glutaraldehyde is a crosslinker, which rigidifies macromolecular structures and shuts down their reactivity.
The aldehyde groups in Glutaraldehyde are susceptible to formation of imines by reaction with the amines of lysine and nucleic acids.
The derivatives from aldol condensation of pairs of Glutaraldehyde also undergo imine formation.



ALTERNATIVE PARENTS of Glutaraldehyde:
*Short-chain aldehydes
*Organic oxides
*Hydrocarbon derivatives



SUBSTITUENTS of Glutaraldehyde:
*Alpha-hydrogen aldehyde
*Organic oxide
*Hydrocarbon derivative
*Short-chain aldehyde
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of GLUTARALDEHYDE:
Chemical formula: C5H8O2
Molar mass: 100.117
Appearance: Clear liquid
Odor: pungent
Density: 1.06 g/mL
Melting point: −14 °C (7 °F; 259 K)
Boiling point: 187 °C (369 °F; 460 K)
Solubility in water: Miscible, reacts
Vapor pressure: 17 mmHg (20°C)[2]
Molecular Weight: 100.12
XLogP3-AA: -0.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 4
Exact Mass: 100.052429494
Monoisotopic Mass: 100.052429494
Topological Polar Surface Area: 34.1 Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 51.1
Isotope Atom Count: 0

Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Melting Point: -15 °C
Boiling Point: 189.0±13.0 °C at 760 mmHg
Flash Point: 66.0±16.8 °C
Molecular Formula: C5H8O2
Molecular Weight: 100.116
Density: 0.9±0.1 g/cm3
Physical Form: Liquid
Melting Point: -5°C
Boiling Point: 100°C
Density: 1.060g/cm³
Packaging: Glass Bottle
Vapor Pressure: 16.4mmHg at 20°C
Quantity: 4 L
Assay Percent Range: 24.0 to 26.5 %
Linear Formula: HC(O)(CH2)3CHO
Merck Index: 15, 4508
Formula Weight: 100.12


Rotatable Bond Count: 4
Exact Mass: 104.08373g/mol
Monoisotopic Mass: 104.08373g/mol
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 25.3
Covalently-Bonded Unit Count: 1
Physical State: Liquid
Color/Form: Viscous, oily liquid, Colorless
Boiling Point: 239℃
Melting Point: -16℃
Flash Point: 135 °C
Solubility: Miscible with water;
Soluble in water;
Miscible with methanol, ethanol, acetone, ethyl acetate.
Soluble in ether (25 °C) 11% w/w.
Limited solubility in benzene, trichloroethylene, methylene chloride, petroleum ether, heptane.
Soluble in alcohols, acetone, and relatively insoluble in aliphatic and aromatic hydrocarbons

Density: 0.9941 g/cm cu at 20 °C; 0.9858 g/cm cu at 25 °C
Appearance: Colorless to Almost colorless clear liquid
H-Bond Donor: 2
H-Bond Acceptor: 2
Vapor Pressure: 0.00 mmHg;3.90X10-3 mm Hg at 25 °C
Stability: Stable under recommended storage conditions.
Viscosity: 128 mPa.s at 20 °C
Refractive Index: Index of refraction: 1.4499 at 20 °C
Heat of Vaporization: 82.4 kJ/mol at 25 °C
Decomposition: When heated to decomposition it emits acrid smoke and irritating fumes.
Other Experimental:
Henry's Law constant = 3.1X10-7atm-cu m/mol at 25 °C (est)
Hydroxyl radical reaction rate constant = 1.3X10-11 cu cm/mole-sec at 25 °C (est)
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity: 1.00500 to 1.01100 @ 25.00 °C.
Pounds per Gallon - (est).: 8.363 to 8.413

Refractive Index: 1.43000 to 1.43600 @ 20.00 °C.
Boiling Point: 188.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.600000 mmHg @ 30.00 °C.
Flash Point: > 300.00 °F. TCC ( > 148.89 °C. )
logP (o/w): -0.180 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: store under nitrogen.
Storage: refrigerate in tightly sealed containers. store under nitrogen.
Soluble in: alcohol
water, 1.672e+005 mg/L @ 25 °C (est)
Melting point: -10 °C
Boiling point: 101 °C
Density: 1.06
vapor density: 0.8 (vs air)
vapor pressure: 0.0203 hPa at 20 °C
form: Liquid
color: Yellow
Specific Gravity: 0.918 to 1.123
Odor: Sharp, fruity, medicinal

PH Range: 3.1 - 4.5
Water Solubility: Soluble in water
Min. Purity Spec: ca. 50% in Water, ca. 5.6mol/L
Physical Form (at 20°C): Liquid
Melting Point: -5°C
Boiling Point: 100°C
Density: 1.06
Refractive Index: 1.373
Physical state: liquid
Color: colorless
Odor: characteristic
Melting point/freezing point:
Melting point: -6 °C
Initial boiling point and boiling range: 100,5 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable


Autoignition temperature: Not applicable
Decomposition temperature: No data available
pH: > 3,0 at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: at 20 °C soluble
Partition coefficient:
n-octanol/water: No data available
Vapor pressure: 0,27 hPa at 20 °C
Density: 1,06 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information:
Relative vapor density: 0,8

Formula: C5H8O2
Formula mass: 100.12
Melting point, °C: -10
Boiling point, °C: 101
Vapor pressure, mmHg: 0.6 (25 C)
Vapor density (air=1): 0.8
Evaporization number: 0.9 (butyl acetate=1)
Critical temperature: 360
Critical pressure: 41.1
Density: 1.014 g/cm3 (20 C)
Solubility in water: Miscible
Surface tension: Refractive index: 1.43 (20 C)
Partition coefficient, pKow: -0.34
Heat of vaporization: 42.5 kJ/mol

Molar mass: 100.117
Appearance: Clear liquid
Odor: pungent
Density: 1.06 g/mL
Melting point: −14 °C (7 °F; 259 K)
Boiling point: 187 °C (369 °F; 460 K)
Solubility in water: Miscible, reacts
Vapor pressure: 17 mmHg (20°C)
Molecular Weight: 100.12
XLogP3-AA: -0.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 4
Exact Mass: 100.052429494
Monoisotopic Mass: 100.052429494
Topological Polar Surface Area: 34.1 Ų
Heavy Atom Count: 7



FIRST AID MEASURES of GLUTARALDEHYDE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Call a physician immediately.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Call a physician immediately.
Do not attempt to neutralise.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GLUTARALDEHYDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of GLUTARALDEHYDE:
-Extinguishing media:
*Suitable extinguishing media:
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLUTARALDEHYDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,40 mm
Break through time: > 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: > 240 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of GLUTARALDEHYDE:
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions
Tightly closed.
Keep locked up or in an area accessible only to qualified or authorized persons.
Recommended storage temperature see product label.
*Storage class:
Storage class (TRGS 510): 8B: Non-combustible



STABILITY and REACTIVITY of GLUTARALDEHYDE:
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
Pentanedial
Glutaraldehyde
Glutardialdehyde
Glutaric acid dialdehyde
Glutaric aldehyde
Glutaric dialdehyde
1,5-Pentanedial
glutaraldehyde
Pentanedial
Glutaral
111-30-8
Glutaric dialdehyde
Cidex
1,5-Pentanedial
Sonacide
Glutardialdehyde
Pentane-1,5-dial
Glutaric acid dialdehyde
Glutaric aldehyde
Glutaraldehyd
Glutaralum
Glutarol
Ucarcide
Aldesan
Alhydex
Hospex
1,3-Diformylpropane
Gluteraldehyde
1,5-Pentanedione
Aldesen
Novaruca
Sporicidin
Sterihyde L
Aldehyd glutarowy
NCI-C55425
Glutaclean
Sterihyde
Aqucar
Veruca-sep
Relugan GT
Relugan GTW
component of Cidex
Glutarex 28
NSC 13392
Sonacide (TN)
Cidex 7
Ucarcide 250
Relugan GT 50
Sterihyde L (TN)
Coldcide-25 microbiocide
NSC-13392
Glutaral (JAN/USP/INN)
Potentiated acid glutaraldehyde
CHEBI:64276
T3C89M417N
1, 5-Pentanedial
MFCD00007025
NCGC00091110-01
DSSTox_CID_5355
DSSTox_RID_77761
DSSTox_GSID_25355
Glutaraldehyde Solution, 25%
Caswell No. 468
Glutaraldehyde solution
1,3-Diformyl propane
Diswart
Gludesin
Glutarol-1,5-pentanedial
Polyglutaraldehyde
CAS-111-30-8
Poly(glutaraldehyde)
CCRIS 3800
HSDB 949
EINECS 203-856-5
EPA Pesticide Chemical Code 043901
Glutaric dialdehyde solution
BRN 0605390
pentandial
Dioxopentane
Glutural
Ucarset
Verucasep
Glutaraldehyde solution, for electron microscopy, ~25% in H2O
Virsal
UNII-T3C89M417N
Glutaral(usan)
glutaric dihydride
GLUTARALDEHYDE, 25% SOLN
Glutaral concentrate
Bactron K31
Ucarcide 225
Glutaraldehyde solution (50% or less)
Pentanedial, homopolymer
pentane-1,5-dialdehyde
Protectol GDA, GT 50
SCHEMBL836
WLN: VH3VH
GLUTARAL [WHO-DD]
EC 203-856-5
GLUTARALDEHYDE [MI]
Pentane-1,5-dial solution
GLUTARALDEHYDE [FCC]
4-01-00-03659 (Beilstein Handbook Reference)
BIDD:ER0299
Glutaraldehyde Solution, 50%
CHEMBL1235482
DTXSID6025355
AMY3308
Bio1_000462
Bio1_000951
Bio1_001440
Glutaraldehyde solution, 25% w/w
Glutaraldehyde solution, 50% w/w
Glutaraldehyde solution, 70% w/w
NSC13392
STR01121
ZINC1729593
Tox21_111083
Tox21_201742
Tox21_303295
STL281872
AKOS008967285
DB03266
Glutaric dialdehyde, 25%sol. In water
Glutaric dialdehyde, 25% sol. in water
NCGC00091110-02
NCGC00091110-03
NCGC00257231-01
NCGC00259291-01
GLUTARAL CONCENTRATE [USP MONOGRAPH]
Glutaraldehyde solution, 25 wt. % in H2O
Glutaraldehyde solution, 50 wt. % in H2O
FT-0626730
G0067
G0068
EN300-18037
D01120
Glutaraldehyde solution, for synthesis, 25.0%
Glutaraldehyde solution, Grade II, 25% in H2O
A802339
Q416475
Glutaraldehyde solution, for in vitro diagnostic use
Q-201162
Glutaric dialdehyde solution, 50 wt. % in H2O, FCC
Z57127529
F2191-0161
Glutaraldehyde solution, SAJ first grade, 20.0-26.0%
Glutaraldehyde solution, technical, ~25% in H2O (2.6 M)
Glutaraldehyde solution, technical, ~50% in H2O (5.6 M)
Glutaraldehyde solution, 1.2 % (w/v) glutaraldehyde in H2O
Glutaraldehyde solution, for electron microscopy, ~50% in H2O
Glutaraldehyde solution, for electron microscopy, ~8% in H2O
Glutaraldehyde solution, 50% in H2O, suitable for photographic applications
Glutaraldehyde solution, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
Glutaraldehyde solution, Grade I, 50% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
Glutaraldehyde solution, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
UN2810
glutaraldehyde
Pentanedial
Glutaral
Glutaric dialdehyde
Cidex
Glutardialdehyde
1,5-Pentanedial
Sonacide
Glutaric aldehyde
Pentane-1,5-dial
Glutaraldehyd
Glutaric acid dialdehyde
Glutaralum
Glutarol
Ucarcide
Aldesan
Alhydex
Hospex
1,3-Diformylpropane
Gluteraldehyde
1,5-Pentanedione
Aldesen
Novaruca
Sporicidin
Aldehyd glutarowy
NCI-C55425
Glutaclean
Sterihyde
Aqucar
Veruca-sep
Sterihyde L
Relugan GT
Relugan GTW
component of Cidex
Glutarex 28
NSC 13392
Sonacide (TN)
Cidex 7
Ucarcide 250
UNII-T3C89M417N
Relugan GT 50
Sterihyde L (TN)
Coldcide-25 microbiocide
Glutaral (JAN/USP/INN)
Potentiated acid glutaraldehyde
CHEBI:64276
T3C89M417N
1, 5-Pentanedial
NSC-13392
NCGC00091110-01
DSSTox_CID_5355
DSSTox_RID_77761
DSSTox_GSID_25355
Glutaraldehyde Solution, 25%
Caswell No. 468
Glutaraldehyde solution
1,3-Diformyl propane
Diswart
Gludesin
Glutarol-1,5-pentanedial
Polyglutaraldehyde
Poly(glutaraldehyde)
CCRIS 3800
HSDB 949
EPA Pesticide Chemical Code 043901
BRN 0605390
pentandial
Dioxopentane
Glutural
Ucarset
Verucasep
Glutaraldehyde solution, for electron microscopy, ~25% in H2O
Virsal
Glutaral(usan)
glutaric dihydride
GLUTARALDEHYDE, 25% SOLN
Glutaral concentrate
Bactron K31
Ucarcide 225
Glutaraldehyde solution (50% or less)
Glutaraldehyde solution, 25% in water
Pentanedial, homopolymer
pentane-1,5-dialdehyde
Glutaral, INN, USAN
Protectol GDA, GT 50
SCHEMBL836
WLN: VH3VH
BIDD:ER0299
Glutaraldehyde Solution, 50%
CHEMBL1235482
DTXSID6025355
AMY3308
Bio1_000462
Bio1_000951
Bio1_001440
NSC13392
STR01121
ZINC1729593
Tox21_111083
Tox21_201742
Tox21_303295
STL281872
AKOS008967285
DB03266
Glutaric dialdehyde, 25%sol. In water
Glutaric dialdehyde, 25% sol. in water
NCGC00091110-02
NCGC00091110-03
NCGC00257231-01
NCGC00259291-01
Glutaraldehyde solution, 25 wt. % in H2O
Glutaraldehyde solution, 50 wt. % in H2O
FT-0626730
G0067
G0068
EN300-18037
D01120
Glutaraldehyde solution, for synthesis, 25.0%
Glutaraldehyde solution, Grade II, 25% in H2O
A802339
Q416475
Glutaraldehyde solution, for in vitro diagnostic use
Q-201162
Glutaric dialdehyde solution, 50 wt. % in H2O, FCC
F2191-0161
Pentanedial
1,5-Pentanedial
5-Oxopentanal
Aldesan
Banicide
Biomate 743
Cidex
Cidex 7
Cidex-Dialyzer
Cidexplus
Cleancide 275
Diglutaric Aldehyde
Eimaldehyde
Floperm 665X1
Formula H
Glu-Cid
Glutaclean
Glutaral
Glutardialdehyde
Glutarex 28
Glutaric Acid Dialdehyde
Glutaric Dialdehyde
Glutohyde
Hospex
KS 02
Kcide 850
Maxicide Plus
Metricide Plus
NSC 13392
Panavirocide
Piror 850
Relugan GT
Relugan GT 50
Relugan GTW
Sonacide
Sporicidin
Sterihyde
Sterihyde L
Sterisol S
Surcide G 50
T 352
Ucarcide 250
Wavicide 01
glutaraldehyde
glutaric dialdehyde
1,5-pentanedione
glutardialdehyde
glutaclean
glutaral
glutaric acid dialdehyde
glutarex 28
pentanedial
Glutaraldehyde Solution BP
Pentanedial
1,5-Pentanedial
glutaraldehyde sol,F. E. M.,~50% in H2O
glutaraldehyde sol,for E. M.,~25% in H2O
glutaraldehyde grade I
glutaraldehyde 50% aqueous solution*photographic
glutaraldehyde grade I 50% aqueous*solution
glutaraldehyde grade I 70% aqueous*solution
Glutaraldehyde, 25% Aqueous Solution
Glutaraldehyde 50% solution
Glutarldehyde
Glutaraldehyde
Glutaraldehyde disinfectant
1,3-Diformylpropane
1,5-Pentanedial
1,5-Pentanedione
Aldehyd glutarowy
Aldesan
Aldesen
Alhydex
Aqucar
Cidex
Cidex 7
Coldcide-25 microbiocide
component of Cidex
Glutaclean
Glutaral
Glutaraldehyd
Glutaraldehyde
Glutaraldehyde solution
Glutaralum
Glutardialdehyde
Glutarex 28
Glutaric acid dialdehyde
Glutaric aldehyde
Glutaric dialdehyde
Glutarol
Gluteraldehyde
Hospex
Novaruca
Pentane-1,5-dial
Potentiated acid glutaraldehyde
Relugan GT
Relugan GT 50
Relugan GTW
Sonacide
Sporicidin
Sterihyde
Ucarcide
Ucarcide 250
Veruca-sep
BRN 0605390
CASWELL NO. 468
CCRIS 3800
EPA PESTICIDE CHEMICAL CODE 043901
HSDB 949
NCI-C55425
NSC 13392
Glutaraldehyde
Glutaric dialdehyde
Pentanedial
1,3-diformylpropane
1,5-Pentanedial
Glutaric Aldehyde
Glutaric Acid Dialdehyde
Alhydex
Cidex
Dioxopentane
Glutaral
Glutardialdehyde
Glutarol
Sporicidin
Ucarcide
Veruca-sep
Gluteraldehyde
1,5-pentanedione
potentiated acid glutaraldehyde
sonacide
Pentane-1,5-dial
Aldesan
Coldcide-25 microbiocide



GLUTARALDEHYDE %24
GLUTARALDEHYDE %24 Glutaraldehyde %24 the free encyclopedia Jump to navigationJump to search Glutaraldehyde %24 Skeletal formula of Glutaraldehyde %24 Ball-and-stick model of the Glutaraldehyde %24 molecule Glutaraldehyde %24 Infobox references Glutaraldehyde %24, sold under the brandname Cidex and Glutaral among others, is a disinfectant, medication, preservative, and fixative.[3][4][5][6] As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals.[3] As a medication, it is used to treat warts on the bottom of the feet.[4] Glutaraldehyde %24 is applied as a liquid.[3] Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde %24 is effective against a range of microorganisms including spores.[3][7] Glutaraldehyde %24 is a dialdehyde.[8] It works by a number of mechanisms.[7] Glutaraldehyde %24 came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines.[10] There are a number of other commercial uses such as leather tanning.[11] Disinfection Glutaraldehyde %24 is used as a disinfectant and medication.[3][4][12] Usually applied as a solution, it is used to sterilize surgical instruments and other areas.[3] Fixative Glutaraldehyde %24 is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy. It kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde[13] as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.[citation needed] Another application for treatment of proteins with Glutaraldehyde %24 is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.[14] In a related application, Glutaraldehyde %24 is sometimes employed in the tanning of leather and in embalming.[citation needed] Safety Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde %24 is effective against a range of microorganisms including spores.[3][7] As a strong sterilant, Glutaraldehyde %24 is toxic and a strong irritant.[16] There is no strong evidence of carcinogenic activity.[17] Some occupations that work with this chemical have an increased risk of some cancers.[17] Mechanism of action A number of mechanisms have been invoked to explain the biocidal properties of Glutaraldehyde %24.[7] Like many other aldehydes, it reacts with amines and thiol groups, which are common functional groups in proteins. Being bi-function, it is also a potential crosslinker.[18] Production and reactions Synthesis of Glutaraldehyde %24 via the Diels-Alder reaction. Glutaraldehyde %24 is produced industrially by the oxidation of cyclopentene. Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.[19] Like many other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), Glutaraldehyde %24 converts in aqueous solution to various hydrates that in turn convert to other equilibrating species.[clarification needed][20][19] Monomeric Glutaraldehyde %24 polymerizes by aldol condensation reaction yielding alpha, beta-unsaturated poly-Glutaraldehyde %24. This reaction usually occurs at alkaline pH values.[medical citation needed] History and culture Glutaraldehyde %24 came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[10] There are a number of other commercial uses such as leather tanning.[11] A Glutaraldehyde %24 solution of 0.1% to 1.0% concentration may be used as a biocide for system disinfection and as a preservative for long-term storage. It is a sterilant, killing endospores in addition to many microorganisms and viruses.[21] As a biocide, Glutaraldehyde %24 is a component of hydraulic fracturing ("fracking") fluid. It is included in the additive called Alpha 1427.[22] Bacterial growth impairs extraction of oil and gas from these wells. Glutaraldehyde %24 is pumped as a component of the fracturing fluid to inhibit microbial growth.[medical citation needed] Publisher Summary This chapter describes the biological uses and importance of Glutaraldehyde %24. The modern industrial production of the aldehyde involves a two-step synthesis from an interaction of acrolein with vinyl ethyl ether to produce an ethoxy dihydropyran that is then hydrolyzed with water to form Glutaraldehyde %24 and ethanol. Glutaraldehyde %24 is used in three major areas: (1) leather tanning, (2) sterilization and disinfection, and (3) tissue fixation for electron microscopy. This chapter is discusses the latter two of these subjects. Investigation of the effects of a number of fixatives on plant cells from the root tip of Phaseolus vulgaris both at the light- and electron microscopic levels, including Glutaraldehyde %24, osmium tetroxide, formaldehyde, acrolein, potassium dichromate, Clarke's fluid and chromic acid, acetic and water showed that Glutaraldehyde %24 was an excellent general fixative. The chapter discusses the recently introduced Glutaraldehyde %24-containing fixatives. Overview CAS No. 111-30-8 Glutaraldehyde %24, C5H8O2 or OCH(CH₂)₃CHO, is a transparent oily, liquid with a pungent odor. Exposure to Glutaraldehyde %24 may cause the following symptoms: throat and lung irritation, asthma and difficulty breathing, dermatitis, nasal irritation, sneezing, wheezing, burning eyes, and conjunctivitis. Workers may be harmed from exposure to Glutaraldehyde %24. Workers can be exposed to Glutaraldehyde %24 through inhalation or skin contact. The level of exposure depends upon the dose, duration, and work being done. Glutaraldehyde %24 is used for a number of applications: NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses Glutaraldehyde %24, please read chemical labels and the accompanying Safety Data Sheet for hazard information. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures. The following resources provide information about occupational exposure to Glutaraldehyde %24. Useful search terms for Glutaraldehyde %24 include “glutaric dialdehyde,” and “1,5-pentanedial.” Related NIOSH Resources NIOSHTIC-2 search results on Glutaraldehyde %24 A searchable database of worker safety and health publications, documents, grant reports, and journal articles supported in whole or in part by NIOSH. Aldehydes, screening (No. 2539) NIOSH Manual of Analytical Methods (NMAM) Selected Publications NIOSH Skin Notation Profiles: Glutaraldehyde %24 DHHS (NIOSH) Publication No. 2011-149 (2011) NIOSH Glutaraldehyde %24: Occupational Hazards in Hospitals DHHS (NIOSH) Publication No. 2001-115. Provides information about the adverse health effects of Glutaraldehyde %24, describes how hospital workers can be exposed to Glutaraldehyde %24, and identifies control methods and work practices to prevent or reduce exposure. En Español NIOSH Current Intelligence Bulletin 55: Carcinogenicity of Acetaldehyde and Malonaldehyde, and Mutagenicity of Related Low-Molecular-Weight Aldehydes DHHS (NIOSH) Publication No. 91-112 Information about the potential carcinogenicity and mutagenicity of acetaldehyde and malonaldehyde, the chemical reactivity and mutagenicity of nine related aldehydes, and includes guidelines for minimizing can be exposed to Glutaraldehyde %24, and identifies control methods and work practices to prevent or reduce exposure. NIOSH Current Intelligence Bulletin 55: Carcinogenicity of Acetaldehyde and Malonaldehyde, and Mutagenicity of Related Low-Molecular-Weight Aldehydes DHHS (NIOSH) Publication No. 91-112 Information about the potential carcinogenicity and mutagenicity of acetaldehyde and malonaldehyde, the chemical reactivity and mutagenicity of nine related aldehydes, and includes guidelines for minimizing occupational exposures. NIOSH Registry of Toxic Effects of Chemical Substances (RTECS): Glutaraldehyde %24 Includes detailed information about toxic health effects and official exposure recommendations and standards for Glutaraldehyde %24. Related Resources Agency for Toxic Substances & Disease Registry (ASTDR): Glutaraldehyde %24 ASTDR Toxciological Profile for Glutaraldehyde %24 ASTDR ToxGuide: Glutaraldehyde %24pdf icon FDA-Cleared Sterilants and High Level Disinfectantsexternal icon EPA Chemistry Dashboard: Glutaraldeydeexternal icon EPA: Reducing Ethylene Oxide and Glutaraldehyde %24 Usepdf iconexternal icon Occupational Safety and Health Administration (OSHA) Best Practices for the Safe Use of Glutaraldehyde %24 in Health Careexternal icon OSHA Hospital eTool: Glutaraldehyde %24external icon OSHA Hazard Communicationexternal icon New Jersey Hazardous Substance Fact Sheets: Glutaraldehyde %24external icon International Resources European Chemicals Agency (ECHA): Glutaraldehyde %24external icon INCHEM-International Chemical Safety Data Card: Glutaraldehyde %24external icon Gestis Substance Databaseexternal icon OECD Global Portal to Information on Chemical Substancesexternal icon Organization for Economic Cooperation and Development (OECD) Screening Information Data Sets (SIDS): Glutaraldehyde %24external icon Glutaraldehyde %24 has been a high-level disinfectant for over 50 years. As a disinfectant, it is used to eliminate harmful microorganisms on surgical instruments and has other uses as a fixative or preservative in other parts of a healthcare facility. However, it can get into the air from its use as a disinfectant and employees and patients can be exposed to the chemical. Prolonged exposure to employees can become a problem. At CHT we provide solutions to maintain the health of your employees with environmental monitoring to ensure their well-being. We understand it's crucial to keep your employees safe and your healthcare facility compliant. In this article, we discuss the health effects and managing the chemical safety of Glutaraldehyde %24 in the workplace. Glutaraldehyde %24 How is Glutaraldehyde %24 Used in Healthcare Facilities? Glutaraldehyde %24 is used as a cold sterilant to disinfect a variety of heat-sensitive instruments, such as endoscopes, dialysis equipment, and more. It is used as a high-level disinfectant for those surgical instruments that cannot be heat sterilized. Glutaraldehyde %24 is used for several applications in healthcare facilities: There are risks associated with exposure to Glutaraldehyde %24. Occupational Hazards in Healthcare Facilities Glutaraldehyde %24 has been linked with a variety of health effects – ranging from mild to severe – including asthma, breathing difficulties, respiratory irritation, and skin rashes (Pryor, 1984; Crandall, 1987). "Rooms in which Glutaraldehyde %24 disinfection/sterilization is performed should be large enough to ensure the adequate dilution of vapor and should have a minimum air exchange rate of ten air exchanges per hour." [source] PPE protects workers against the hazards of using high-level disinfectants such as Glutaraldehyde %24. Regardless of the type of disinfectant used, facilities should use the proper PPE designed to protect their skin and eyes from contact. One of the earliest indications of the potential antimicrobial activity of Glutaraldehyde %24 came from the results of a survey of sporicidal activity of saturated dialdehydes in a search for an efficient substitute for formaldehyde (Pepper & Lieberman 1962). Further studies by Pepper & Chandler (1963) revealed that Glutaraldehyde %24 in alcoholic solution was superior as a sporicidal agent to both formaldehyde and glyoxal. In their claims for Glutaraldehyde %24 as a chemical sterilizing solution, Stonehill et a/. (1963) pointed out that aqueous solutions of Glutaraldehyde %24 were mildly acidic and needed to be buffered by suitable alkalinating agents to a pH of 7.5-8.5 for antimicrobial activity. A 2.0% (w/v) Glutaraldehyde %24 buffered to alkaline pH by addition of 0.3‘j/, (w/v) sodium bicarbonate was advocated to provide the minimum concentration and conditions necessary for rapid sporicidal activity. This solution has a greater sporicidal activity than 8% formaldehyde (Table 3). The value of this alkaline solution was later confirmed by Snyder & Cheatle (1965). Subsequently Glutaraldehyde %24 has always been recommended for use as an alkaline solution at pH 7.5-8.5 and towards the end of 1963, a 2% solution (Cidex) was marketed by Ethicon Inc., requiring ‘activation’ with 0.3% (w/v) sodium bicarbonate before use as a chemosterilizer. The time required for sterilization by a chemical agent is based upon the killing time achieved by the agent against a reasonable challenge of spores which are considered to be the most resistant. At the use-dilution of 2%, Glutaraldehyde %24 was capable of killing spores of Bacillus and Clostridium sp. in 3 h (Stonehill et a/. 1963; Borick et al. 1964). Rubbo et a/. (1967) reported a 99.99% kill of spores of B. anthracis and CI. tetani in 15 and 30 min respectively. It was apparent from their results that not all species were equally susceptible and of those organisms tested B. pumilis was the most resistant. Boucher (1974) found that B. subtilis spores were the most resistant to treatment with Glutaraldehyde %24. Using the Association of Official Analytical Chemists (AOAC) sporicidal test and vacuum-dried spores, he found that 10 h was necessary for complete kill. Other work, however, using similar time-survivor measurements and aqueous suspensions of B.subtilis spores, indicated that a 3 h contact period gave approximately a six log drop in viable count (Sierra & Boucher 1971; Kelsey et al. 1974; Forsyth 1975; Miner et al. 1977). Vegetative bacteria are readily susceptible to the action of Glutaraldehyde %24. As shown in Table 4, a 0.02% aqueous alkaline solution is rapidly effective against Gram positive and Gram negative species, whilst a 2% solution is capable of killing many vegetative species, including Staphylococcus aureus, Proteus vulgaris, Escherichia coli and Pseudomonas aeruginosa within 2 min (Stonehill el al. 1963). McGucken & Woodside (1973) reported a complete kill in 10 min of Esch. coli (2 x lo8 cells/ml) by 100 pg/ml alkaline Glutaraldehyde %24 compared with a 45% kill produced by the unactivated acid solution. In a comparative study of Cidex and Savlon by Leers eta/. (1974) stainless steel penicylinders, neoprene '0' rings and polyvinyl tubing were used as carriers for a range of organisms including Ps.aeruginosa and Mycobacterium smegmatis to simulate in-use conditions for the sterilization of instruments, catheter tubing and anaesthetic equipment. Cidex was effective on all three carriers, whereas Savlon was only partially effective, especially against Ps.aeruginosa and Staph.aureus. The tubercle bacillus has gained a justified reputation for being one of the most difficult species to destroy and its resistance to antibacterial agents is considered to be intermediate between sporulating and non-sporing organisms (Spaulding et al. 1977). Although good tuberculocidal activity has been attributed to Glutaraldehyde %24 (Stonehill et al. 1963; Borick et al. 1964), subsequent studies have shown that it has a slow action against Myco.tuberculosis (Rubbo et al. 1967), being less effective than formaldehyde or iodine (Bergan & Lystad 1971). It has been claimed by Relyveld (1977) that the activity of Glutaraldehyde %24 is equivalent or superior to that of hypochlorite with the exception of its effectiveness against mycobacteria. The picture is somewhat confused by the findings of Collins & Montalbine (1976) that the dialdehyde was rapidly mycobactericidal at room temperature. It must be added that the experimental technique adopted by the latter authors leaves a very considerable doubt about the validity of the conclusions reached. B. Antifingal activity Antifungal activity of Glutaraldehyde %24 was first demonstrated by Stonehill et al. (1963), who reported that growth of Trichophyton interdigitale was inhibited by a 5 min exposure to a 2% alkaline solution and that this solution was more potent than a number of other commercially available preparations tested. A 1% solution is also fungicidal (Dabrowa et al. 1972), but porous surfaces contaminated with Candida albicans and Microsporium gypseum are significantly more difficult to disinfect with Glutaraldehyde %24 than are smooth surfaces (Tadeusiak 1976). Aspergillus niger is more resistant than other fungi to Glutaraldehyde %24 (Rubbo et al. 1967; Gorman & Scott 1977a). In common with a range of other fungal species, however, both mycelial growth and sporulation are inhibited by 0.5% alkaline Glutaraldehyde %24 while spore swelling is entirely halted by a 0.5% solution. Fungicidal activity is also demonstrated (Fig. 1). What Is Glutaraldehyde %24 Used For? Glutaraldehyde %24 has a variety of uses in many industries and occupations. It is most commonly found in the healthcare industry, used to disinfect medical equipment that cannot be heat sterilized. The main uses of Glutaraldehyde %24 include: Glutaraldehyde %24 (C5H8O2) is most often used in a diluted form with solutions ranging from 0.1 to 50 percent Glutaraldehyde %24 in water. It is a colorless, oily liquid and sometimes has an odor of rotten apples. In a vapor state, Glutaraldehyde %24 has a pungent odor, with an odor threshold level of 0.04 parts per million (ppm).Trade names for Glutaraldehyde %24-containing formulations include Cidex®, Sonacide®, Sporicidin®, Hospex®, Omnicide®, Metricide®, Rapicide® and Wavicide®. Exposure Limits OSHA has not established a permissible exposure limit (PEL) for Glutaraldehyde %24. NIOSH has established a recommended exposure limit (REL) for Glutaraldehyde %24 of 0.2 ppm. This is a time-weighted average (TWA) exposure limit for up to a 10-hour workday during a 40-hour workweek. The American Conference of Governmental Industrial Hygienists (ACGIH) has set a ceiling Threshold Limit Value (TLV) of 0.05 ppm. This is the airborne concentration that should not be exceeded during any part of the work shift. Does Glutaraldehyde %24 Present a Health Hazard? Glutaraldehyde %24 is an irritant to the skin, eyes and respiratory system. Exposure symptoms might include burning sensation, dermatitis, headache, coughing, shortness of breath, nausea and vomiting. Continuous repeated exposure to Glutaraldehyde %24 might intensify the skin and respiratory irritant effects. Anyone with a history of skin or eye disorders might be at an increased risk from exposure. First Aid Eyes: If Glutaraldehyde %24 contacts the eyes, immediately flush the eyes with large amounts of water, occasionally lifting the lower and upper lids. Seek medical attention immediately. Contact lenses should not be worn when working with Glutaraldehyde %24. Skin: If Glutaraldehyde %24 contacts the skin, immediately flush the contaminated skin with water for at least 15 minutes. If Glutaraldehyde %24 penetrates clothing, immediately remove the clothing and flush the skin with water for at least 15 minutes. Promptly seek medical attention. Inhalation: If large amounts of Glutaraldehyde %24 are inhaled, move the exposed person to fresh air at once. If breathing has stopped, immediately begin cardiopulmonary resuscitation (CPR). Keep the person warm and at rest. Get medical attention as soon as possible. Ingestion: Get medical attention immediately. What Type of Personal Protective Equipment Should Be Used with Glutaraldehyde %24? Personal protective equipment (PPE) must be used with engineering and administrative controls to help prevent Glutaraldehyde %24 exposure. Safety goggles should be considered where concentrated Glutaraldehyde %24 is used or where splashing may occur, it is best to use indirect-vented or non-vented goggles, and to avoid goggles with foam padding. Protective clothing should be worn when handling Glutaraldehyde %24. Polyethylene, polyvinyl chloride, Viton™, butyl rubber, natural rubber latex, neoprene and nitrile rubber provide adequate protection from Glutaraldehyde %24 solutions and are compatible materials for gloves and aprons. Respiratory protection: Although an immediately dangerous to life and health (IDLH) exposure limit has not been established for Glutaraldehyde %24, several respirator manufacturers have issued guidelines. 3M’s respirator selection guide can be found here and while MSA’s can be found here. Air Monitoring Personal monitors, passive-gas monitors and vapor meters can help determine workers' exposure to Glutaraldehyde %24. A: A disinfectant is a chemical or physical agent that is applied to inanimate objects to kill microorganisms. Bleach (sodium hypochlorite), phenolic compounds, and formaldehyde are examples of disinfectants. A sterilant is a chemical or physical process that is applied to inanimate objects to kill all microorganisms as well as spores. Glutaraldehyde %24 and ethylene oxide are examples of sterilants. Q: Where is exposure to Glutaraldehyde %24 most likely? A: Exposure to Glutaraldehyde %24 is most likely in the healthcare industry. It is used in hospitals for cold sterilization of medical supplies and instruments, and also as a disinfectant in urology, endoscopy and dental departments. It is also used as a fixative in X-ray developing solutions. Q: Is Glutaraldehyde %24 considered a fire hazard? A: No, Glutaraldehyde %24 is a non-flammable liquid. Q: What is the recommended protective clothing when handling Glutaraldehyde %24? A: Aprons and other protective clothing made from materials such as polyethylene, polyvinyl chloride, Viton™, butyl rubber, natural rubber latex, neoprene or nitrile rubber can offer protection when handling Glutaraldehyde %24 solutions. Sources OSHA Occupational Chemical Database for Glutaraldehyde %24 National Institute of Occupational Safety and Health, "NIOSH Pocket Guide to Chemical Hazards-Glutaraldehyde %24" National Institute of Occupational Safety and Health, “Workplace Safety and Health Topics – Glutaraldehyde %24”
GLUTARALDEHYDE 35%
Glutaraldehyde 35% Glutaraldehyde, sold under the brandname Cidex and Glutaral among others, is a disinfectant, medication, preservative, and fixative. As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals.[3] As a medication, it is used to treat warts on the bottom of the feet.[4] Glutaraldehyde is applied as a liquid.[3] Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7] Glutaraldehyde is a dialdehyde.[8] It works by a number of mechanisms.[7] Glutaraldehyde came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines.[10] There are a number of other commercial uses such as leather tanning.[11] Uses Disinfection Glutaraldehyde is used as a disinfectant and medication.[3][4][12] Usually applied as a solution, it is used to sterilize surgical instruments and other areas.[3] Fixative Glutaraldehyde is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy. It kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde[13] as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.[citation needed] Another application for treatment of proteins with glutaraldehyde is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.[14] In a related application, glutaraldehyde is sometimes employed in the tanning of leather and in embalming.[citation needed] Wart treatment As a medication it is used to treat plantar warts.[4] For this purpose, a 10% w/v solution is used. It dries the skin, facilitating physical removal of the wart.[15] Trade names include Diswart Solution and Glutarol.[citation needed] Safety Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7] As a strong sterilant, glutaraldehyde is toxic and a strong irritant.[16] There is no strong evidence of carcinogenic activity.[17] Some occupations that work with this chemical have an increased risk of some cancers.[17] Mechanism of action A number of mechanisms have been invoked to explain the biocidal properties of glutaraldehyde.[7] Like many other aldehydes, it reacts with amines and thiol groups, which are common functional groups in proteins. Being bi-function, it is also a potential crosslinker.[18] Production and reactions Synthesis of glutaraldehyde via the Diels-Alder reaction. Glutaraldehyde is produced industrially by the oxidation of cyclopentene. Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.[19] Like many other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), glutaraldehyde converts in aqueous solution to various hydrates that in turn convert to other equilibrating species General description Glutaraldehyde solution is 35% solution of glutaraldehyde in water. Antibacterial action of 2% solution of alkaline glutaraldehyde against various atypical mycobacteria has been investigated.[8] Related Categories Aldehydes, Biochemicals and Reagents, Building Blocks, C1 to C6, Carbohydrates, Carbohydrates A to Z, Carbohydrates G, Carbonyl Compounds, Chemical Synthesis, Core Bioreagents, Monosaccharide, Organic Building Blocks, Research Essentials Quality Level 200 vapor density 1.05 (vs air) vapor pressure 15 mmHg ( 20 °C) concentration 35 wt. % in H2O refractive index n20/D 1.42 density 1.106 g/mL at 25 °C SMILES string [H]C(CCCC([H])=O)=O InChI 1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2 InChI key SXRSQZLOMIGNAQ-UHFFFAOYSA-N Application Cross-linking agent for gelatin,[1][2] poly(vinyl alcohol),[3] and polyheptapeptides.[4] Glutaraldehyde may be used in the following studies: • To compose the fixative solution (Glutaraldehyde + Paraformaldehyde + NaPO4) for use in high-resolution light microscopy and electron microscopy studies.[5] • To study the conjugation of goat anti-horseradish peroxidase with alkaline phosphatase by a reported method.[6] • To compose the primary fixative, which is employed to protect the deterioration of cytoplasmic features of yeast cells during permanganate fixation.[7] Packaging 1 L in glass bottle 25 mL in glass bottle Glutaraldehyde Skeletal formula of glutaraldehyde Ball-and-stick model of the glutaraldehyde molecule Names Preferred IUPAC name Pentanedial[1] Other names Glutaraldehyde Glutardialdehyde Glutaric acid dialdehyde Glutaric aldehyde Glutaric dialdehyde 1,5-Pentanedial Identifiers CAS Number 111-30-8 ☑ 3D model (JSmol) Interactive image ChemSpider 3365 ☑ DrugBank DB03266 ☑ ECHA InfoCard 100.003.356 KEGG D01120 ☑ PubChem CID 3485 UNII T3C89M417N ☑ CompTox Dashboard (EPA) DTXSID6025355 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula C5H8O2 Molar mass 100.117 Appearance Clear liquid Odor pungent[2] Density 1.06 g/mL Melting point −14 °C (7 °F; 259 K) Boiling point 187 °C (369 °F; 460 K) Solubility in water Miscible, reacts Vapor pressure 17 mmHg (20°C)[2] Hazards Safety data sheet CAS 111-30-8 GHS pictograms GHS05: CorrosiveGHS06: ToxicGHS08: Health hazardGHS09: Environmental hazard GHS Signal word Danger GHS hazard statements H302, H314, H317, H331, H334, H400 GHS precautionary statements P260, P264, P270, P271, P272, P273, P280, P284, P301+312, P330, P302+352, P332+313, P304+340, P305+351+338, P311, P403+233, P405, P351 NFPA 704 (fire diamond) NFPA 704 four-colored diamond 220 Flash point noncombustible[2] Threshold limit value (TLV) 0.2 ppm (0.82 mg/m3) (TWA), 0.05 ppm (STEL) Lethal dose or concentration (LD, LC): LD35 (median dose) 134 mg/kg (rat, oral); 2,560 mg/kg (rabbit, dermal) NIOSH (US health exposure limits): REL (Recommended) 0.2 ppm (0.8 mg/m3)[2] Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☑ verify (what is ☑☒ ?) Infobox references Glutaraldehyde, sold under the brandname Cidex and Glutaral among others, is a disinfectant, medication, preservative, and fixative.[3][4][5][6] As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals.[3] As a medication, it is used to treat warts on the bottom of the feet.[4] Glutaraldehyde is applied as a liquid.[3] Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7] Glutaraldehyde is a dialdehyde.[8] It works by a number of mechanisms.[7] Glutaraldehyde came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[10] The wholesale cost in the developing world is about US$1.35–7.40 per liter of 2% solution.[11] There are a number of other commercial uses such as leather tanning.[12] Uses Disinfection Glutaraldehyde is used as a disinfectant and medication.[3][4][13] Usually applied as a solution, it is used to sterilize surgical instruments and other areas.[3] Fixative Glutaraldehyde is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy. It kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde[14] as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.[citation needed] Another application for treatment of proteins with glutaraldehyde is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.[15] In a related application, glutaraldehyde is sometimes employed in the tanning of leather and in embalming.[citation needed] Wart treatment As a medication it is used to treat warts on the bottom of the feet.[4] For this purpose, a 10% w/w solution is used. It dries the skin, facilitating physical removal of the wart.[16] Trade names include Diswart Solution and Glutarol.[citation needed] Safety Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7] As a strong sterilant, glutaraldehyde is toxic and a strong irritant.[17] There is no strong evidence of carcinogenic activity.[18] Some occupations that work with this chemical have an increased risk of some cancers.[18] Mechanism of action A number of mechanisms have been invoked to explain the biocidal properties of glutaraldehyde.[7] Like many other aldehydes, it reacts with amines and thiol groups, which are common functional groups in proteins. Being bi-function, it is also a potential crosslinker.[19] Production and reactions Synthesis of glutaraldehyde via the Diels-Alder reaction. Glutaraldehyde is produced industrially by the oxidation of cyclopentene. Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.[20] Like many other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), glutaraldehyde converts in aqueous solution to various hydrates that in turn convert to other equilibrating species.[clarification needed][21][20] GlutaldehydeHydrateEquilibria.png Monomeric glutaraldehyde polymerizes by aldol condensation reaction yielding alpha, beta-unsaturated poly-glutaraldehyde. This reaction usually occurs at alkaline pH values.[medical citation needed] History and culture Glutaraldehyde came into medical use in the 1960s.[22] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[10] The wholesale cost in the developing world is about US$1.35–7.40 per liter of 2% solution.[11] There are a number of other commercial uses such as leather tanning.[23] A glutaraldehyde solution of 0.1% to 1.0% concentration may be used as a biocide for system disinfection and as a preservative for long-term storage. It is a sterilant, killing endospores in addition to many microorganisms and viruses.[24] As a biocide, glutaraldehyde is a component of hydraulic fracturing ("fracking") fluid. It is included in the additive called Alpha 1427.[25] Bacterial growth impairs extraction of oil and gas from these wells. Glutaraldehyde is pumped as a component of the fracturing fluid to inhibit microbial growth.[medical citation needed] Glutaraldehyde is a colorless, oily liquid with a sharp, pungent odor. Glutaraldehyde is used for industrial, laboratory, agricultural, medical, and some household purposes, primarily for disinfecting and sterilization of surfaces and equipment. For example, it is used in oil and gas recovery operations and pipelines, waste water treatment, x-ray processing, embalming fluid, leather tanning, paper industry, in fogging and cleaning of poultry houses, and as a chemical intermediate in the production of various materials. It may be used in select goods, such as paint and laundry detergent. CDC-ATSDR Toxic Substances Portal Glutaral is used as an antimicrobial agent in sugar mills and as a fixing agent in the immobilisation of glucose isomerase enzyme preparations for use in the manufacture of high fructose corn syrup A polymerized isomer of glutaraldehyde known as polycycloglutaracetal is a fertilizer for aquatic plants. It is claimed that it provides a bioavailable source of carbon for higher plants that is not available to algae. Though not marketed as such due to federal regulations, the biocidal effect of glutaraldehyde kills most algae at concentrations of 0. 5 - 5. 0 ppm. These levels are not harmful to most aquatic fauna and flora. Adverse reactions have been observed by some aquarists at these concentrations in some aquatic mosses, liverworts, and vascular plants. Glutaraldehyde is a colorless liquid with a pungent odor used to disinfect medical and dental equipment. It is also used for industrial water treatment and as a chemical preservative. Glutaraldehyde is an oily liquid at room temperature (density 1. 06 g/mL), and miscible with water, alcohol, and benzene. It is used as a tissue fixative in electron microscopy. It is employed as an embalming fluid, is a component of leather tanning solutions, and occurs as an intermediate in the production of certain industrial chemicals. Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker. The oligomeric state of proteins can be examined through this application. However, it is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. It is a main source of occupational asthma among health care providers. Human Metabolome Database (HMDB) Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. It has a role as a cross-linking reagent, a disinfectant and a fixative. Glutaraldehyde Glutaraldehyde is a commonly used chemical cross-linking agent that forms cross-links between the aldehyde and the e-amine groups of lysine or hydroxylysine in collagen. From: Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair, 2018 Related terms: ResinAntibodyProteinFormaldehydeCacodylic AcidElectron MicroscopyParaformaldehydeUranyl Acetate ChEBI EC NUMBER: 203-856-5 Names and Identifiers of GLUTARALDEHYDE Computed Descriptors of GLUTARALDEHYDE IUPAC Name of GLUTARALDEHYDE pentanedial Molecular Formula Molecular Formula C5H8O2 PHYSICAL AND CHEMICAL PROPERTIES of GLUTARALDEHYDE PHYSICAL STATE: Clear to yellowish liquid MELTING POINT: -14 C BOILING POINT: 187 C SOLUBILITY IN WATER: soluble SOLVENT SOLUBILITY: Soluble in alcohol pH: 3.2 - 4.2 log P: -0.18 VAPOR PRESSURE: 0.6 (mmHg at 25 C) Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2. A pungent colorless oily liquid, glutaraldehyde is used to sterilise medical and dental equipment. It is also used for industrial water treatment and as a preservative. It is mainly available as an aqueous solution, and in these solutions the aldehyde groups are hydrated. Glutaraldehyde is a chemical frequently used as a disinfectant and sterilizing agent against bacteria and viruses (2% solution), an embalming fluid and tissue fixative, a component of leather tanning solutions, and an intermediate in the production of certain sealants, resins, dyes, and electrical products (HSDB, 1996). For commercial purposes, solutions of 99%, 35%, and 20% are available. Glutaraldehyde is also an atmospheric reaction product of cyclohexene. The annual statewide industrial emissions from facilities reporting under the Air Toxics Hot Spots Act in California based on the most recent inventory were estimated to be 29,603 pounds of glutaraldehyde Glutaraldehyde can help to eliminate microbial contamination problems. Based on the powerful and unparalleled antimicrobial action of glutaraldehyde, these high-performance antimicrobials provide excellent control over a wide variety of microorganisms. It has antimicrobial efficacy against bacteria, mold, and yeast at low use concentrations (0.01-0.1% active ingredient). It shows excellent compatibility with anionic, nonionic, and cationic surfactants and biocidal activity over a broad pH and temperature range. Glutaraldehyde containing two aldehyde groups, is used as a disinfectant. It is used in sterilizing medical and dental equipment which cannot be heat sterilized. It is used as a fixative for biological tissues and for leather tanning. It is used as a chemical intermediate to produce other compounds. Glutaraldehyde is a colorless, oily, liquid-chemical with a pungent odor. It is used for a number of applications such as the following: -A cold sterilant in the health care industry -A cross-linking and tanning agent -A biocide in metalworking fluids and in oil and gas pipelines -An antimicrobial in water-treatment systems -A slimicide in paper manufacturing -A preservative in cosmetics -A disinfectant in animal housing -A tissue fixative in histology and pathology labs -A hardening agent in the development of X-rays -In embalming solutions -In the preparation of grafts and bioprostheses -In various clinical applications -In the health care industry, glutaraldehyde is most often used to disinfect equipment that cannot be heat sterilized such as dialysis instruments, surgical instruments, suction bottles, bronchoscopes, endoscopes, and ear, nose, and throat instruments. EC NUMBER: 203-856-5 Names and Identifiers of GLUTARALDEHYDE Computed Descriptors of GLUTARALDEHYDE IUPAC Name of GLUTARALDEHYDE pentanedial Molecular Formula Molecular Formula C5H8O2 PHYSICAL AND CHEMICAL PROPERTIES of GLUTARALDEHYDE PHYSICAL STATE: Clear to yellowish liquid MELTING POINT: -14 C BOILING POINT: 187 C SOLUBILITY IN WATER: soluble SOLVENT SOLUBILITY: Soluble in alcohol pH: 3.2 - 4.2 log P: -0.18 VAPOR PRESSURE: 0.6 (mmHg at 25 C) Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2. A pungent colorless oily liquid, glutaraldehyde is used to sterilise medical and dental equipment. It is also used for industrial water treatment and as a preservative. It is mainly available as an aqueous solution, and in these solutions the aldehyde groups are hydrated. Glutaraldehyde is a chemical frequently used as a disinfectant and sterilizing agent against bacteria and viruses (2% solution), an embalming fluid and tissue fixative, a component of leather tanning solutions, and an intermediate in the production of certain sealants, resins, dyes, and electrical products (HSDB, 1996). For commercial purposes, solutions of 99%, 35%, and 20% are available. Glutaraldehyde is also an atmospheric reaction product of cyclohexene. The annual statewide industrial emissions from facilities reporting under the Air Toxics Hot Spots Act in California based on the most recent inventory were estimated to be 29,603 pounds of glutaraldehyde Glutaraldehyde can help to eliminate microbial contamination problems. Based on the powerful and unparalleled antimicrobial action of glutaraldehyde, these high-performance antimicrobials provide excellent control over a wide variety of microorganisms. It has antimicrobial efficacy against bacteria, mold, and yeast at low use concentrations (0.01-0.1% active ingredient). It shows excellent compatibility with anionic, nonionic, and cationic surfactants and biocidal activity over a broad pH and temperature range. Glutaraldehyde containing two aldehyde groups, is used as a disinfectant. It is used in sterilizing medical and dental equipment which cannot be heat sterilized. It is used as a fixative for biological tissues and for leather tanning. It is used as a chemical intermediate to produce other compounds. Glutaraldehyde is a colorless, oily, liquid-chemical with a pungent odor.
GLUTARALDEHYDE 50%
Glutaraldehyde 50% Glutaraldehyde 50%, sold under the brandname Cidex and Glutaral among others, is a disinfectant, medication, preservative, and fixative. As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals.[3] As a medication, it is used to treat warts on the bottom of the feet.[4] Glutaraldehyde 50% is applied as a liquid. Side effects include skin irritation. If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde 50% is effective against a range of microorganisms including spores. Glutaraldehyde 50% is a dialdehyde.[8] Glutaraldehyde 50% works by a number of mechanisms.[7] Glutaraldehyde 50% came into medical use in the 1960s. Glutaraldehyde 50% is on the World Health Organization's List of Essential Medicines. There are a number of other commercial uses such as leather tanning. Uses of Glutaraldehyde 50% Disinfection of Glutaraldehyde 50% Glutaraldehyde 50% is used as a disinfectant and medication. Usually applied as a solution, it is used to sterilize surgical instruments and other areas. Fixative of Glutaraldehyde 50% Glutaraldehyde 50% is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy. It kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde[13] as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.[citation needed] Another application for treatment of proteins with Glutaraldehyde 50% is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.[14] In a related application, Glutaraldehyde 50% is sometimes employed in the tanning of leather and in embalming. Wart treatment of Glutaraldehyde 50% As a medication it is used to treat plantar warts.[4] For this purpose, a 10% w/v solution is used. It dries the skin, facilitating physical removal of the wart.[15] Trade names include Diswart Solution and Glutarol. Safety of Glutaraldehyde 50% Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde 50% is effective against a range of microorganisms including spores.[3][7] As a strong sterilant, Glutaraldehyde 50% is toxic and a strong irritant.[16] There is no strong evidence of carcinogenic activity.[17] Some occupations that work with this chemical have an increased risk of some cancers.[17] Mechanism of action of Glutaraldehyde 50% A number of mechanisms have been invoked to explain the biocidal properties of Glutaraldehyde 50%.[7] Like many other aldehydes, it reacts with amines and thiol groups, which are common functional groups in proteins. Being bi-function, it is also a potential crosslinker.[18] Production and reactions of Glutaraldehyde 50% Synthesis of Glutaraldehyde 50% via the Diels-Alder reaction. Glutaraldehyde 50% is produced industrially by the oxidation of cyclopentene. Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.[19] Like many other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), Glutaraldehyde 50% converts in aqueous solution to various hydrates that in turn convert to other equilibrating species. Monomeric Glutaraldehyde 50% polymerizes by aldol condensation reaction yielding alpha, beta-unsaturated poly-Glutaraldehyde 50%. This reaction usually occurs at alkaline pH values. History and culture of Glutaraldehyde 50% Glutaraldehyde 50% came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[10] There are a number of other commercial uses such as leather tanning.[11] A Glutaraldehyde 50% solution of 0.1% to 1.0% concentration may be used as a biocide for system disinfection and as a preservative for long-term storage. It is a sterilant, killing endospores in addition to many microorganisms and viruses. As a biocide, Glutaraldehyde 50% is a component of hydraulic fracturing ("fracking") fluid. It is included in the additive called Alpha 1427.[22] Bacterial growth impairs extraction of oil and gas from these wells. Glutaraldehyde 50% is pumped as a component of the fracturing fluid to inhibit microbial growth. RESULTS: An outbreak of six patients occurred in April 2002 and one cirrhotic patient was admitted in July 2008. All patients developed a self-limited syndrome of abdominal pain and bloody diarrhea within 48 h of uncomplicated endoscopy. One severely ill patient required hospitalization to receive intravenous fluid and antibiotics. After the investigation in April 2002, Glutaraldehyde 50%-induced colitis was diagnosed due to a defect in the endoscope-cleansing procedure. There were no deficiencies in the cleansing procedure in July 2008. Considering the patient's concomitant disease, we postulated that ischemic colitis with cirrhosis-related intestinal inflammation and endotoxemia was the possible diagnosis in this sporadic case. CONCLUSIONS: Endoscopists should be aware of this iatrogenic complication in patients presenting with acute rectocolitis, especially in those who have undergone recent endoscopic examination. An outbreak of acute rectocolitis following endoscopy should be considered Glutaraldehyde 50%-induced and should lead to an investigation of cleansing and equipment-disinfection procedures. In the absence of strong evidence of an outbreak, an infectious disease, or contamination of Glutaraldehyde 50%, a sporadic case should be considered ischemic colitis especially in patients with relevant concomitant diseases or predisposing factors. Dermal and intravenous studies in the rat with dilute aqueous Glutaraldehyde 50% solutions (0.075-7.5%) showed that, in dermal tests, approx 5% was absorbed in the rat, and 30-50% in the rabbit. In the intravenous injection tests, approx 12% was absorbed in the rat and approx 33% in the rabbit. There were no significant differences between males and females in the study. The dermal absorption rate constant was low (0.2-2 hr) in each species. The elimination times were long for both intravenous injection (t0.5 for the rat 10 hr, rabbit 15-30 hr) and dermal application (t0.5 for the rat 40-110 hr, rabbit 20-100 hr), possibly due to the binding of Glutaraldehyde 50% to protein and the slow excretion of metabolites. The principal metabolite in both species was CO2 with other metabolites not identified. /It was/ proposed that the metabolism probably involved initial oxidation to corresponding carboxylic acids by aldehyde dehydrogenase, and then further oxidation to CO2. IDENTIFICATION: Glutaraldehyde 50% is a colorless oily liquid with a strong, rotten apple odor. It is very soluble in water. USE: Glutaraldehyde 50% is an antimicrobial chemical commonly used as a disinfectant in hospitals, agriculture and aquaculture, food handling and food storage establishments, and water treatment plants. It is used as a preservative in the manufacture of several consumer products, including cosmetics, cleaners, adhesives, paper, textiles and leathers, paints and coatings, and inks and dyes. Glutaraldehyde 50% is also used as a tissue fixative in laboratories and embalming fluid and in photographic and X-ray development fluids. Glutaraldehyde 50% is used in hydraulic fracturing and off-shore oil operations. EXPOSURE: Workers in hospitals, janitorial services, nursing homes, veterinary hospitals, and commercial and industrial businesses may be exposed to Glutaraldehyde 50% by breathing vapors in air or skin contact. General population exposure may occur by breathing in air and skin contact with consumer products containing Glutaraldehyde 50%. Glutaraldehyde 50% is also present in gasoline and diesel engine exhaust. If Glutaraldehyde 50% is released to air, it will be degraded by reaction with other chemicals and light. If released to water or soil, it is expected to bind to soil particles or suspended particles. Glutaraldehyde 50% is not expected to move into air from wet soils or water surfaces, but may move to air from dry soils. Glutaraldehyde 50% is expected to be degraded by microorganisms and not build up in aquatic organisms. RISK: Runny nose, headache, facial and eye irritation, respiratory problems, skin irritation, and allergic skin reactions have been reported in medical and agricultural workers exposed to Glutaraldehyde 50% liquid or vapor during disinfection and sanitization activities. Asthma has been found in workers repeatedly exposed to Glutaraldehyde 50% vapors. Swelling, burning pain, and sensitivity to light can occur with direct eye contact. The risk of death from cancer was not increased with a history of occupational Glutaraldehyde 50% exposure. Eye irritation and skin irritation/sensitization occur with direct skin contact with diluted Glutaraldehyde 50% in laboratory animals. Severe irritation and burns occur with contact to undiluted gluraraldehyde. Stomach lesions, liver damage, and decreased body weight occurred in laboratory animals given repeated moderate doses of Glutaraldehyde 50% in water. Death occurred at high oral doses. Nasal, throat, and lung lesions and decreased body weights were found in laboratory animals repeatedly exposed to low air concentrations of Glutaraldehyde 50%. Birth defects and abortions were observed in laboratory animals at high oral doses that were also toxic to the mothers. Fertility was not affected in laboratory animals given high oral doses prior to mating. Tumors were not induced in laboratory animals given high oral doses in water or exposed to moderate air concentrations for their lifetime. The American Conference of Governmental Industrial Hygienists determined that Glutaraldehyde 50% is not classifiable as a human carcinogen. The US EPA Carcinogenicity Assessment Review Committee classified Glutaraldehyde 50% as 'Not Likely to be Carcinogenetic to Humans" by any route of exposure, based on the lack tumor induction in several 2-year laboratory animal studies. The potential for Glutaraldehyde 50% to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 13th Report on Carcinogens. Microscopy/histology. Glutaraldehyde 50% is used as a tissue fixative in histology and electron and light microscopy, generally as a 1.5-6% aqueous solution. Aquaculture. Glutaraldehyde 50% is used, generally in conjunction with wetting agents, to control viruses and other micro-organisms in fish farming. Cosmetics. Glutaraldehyde 50% is allowed as a preservative in cosmetics in Europe at concentrations up to 0.1%. It is not allowed in aerosols and sprays. The National Pesticide Information Retrieval System (NPIRS) identifies 24 companies with active labels for products containing the chemical Glutaraldehyde 50%. To view the complete list of companies, product names and percent Glutaraldehyde 50% in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field. In Australia, it is estimated that Glutaraldehyde 50% is distributed in end-use as follows: 55% as a cold disinfectant in the health care industry, 20% in x-ray film processing, 10% in water treatment, 5% in animal housing, 5% in tanning and 5% in other uses such as toilet disinfection, microscopy, aquaculture and air duct disinfection. In France, 50% is used in disinfection/control, 40% in the photographic industry, 5% in the leather industry and 5% in the paper industry. In Norway, 80% is used in industrial cleaning agents and 14% in photocopying developers. In the UK, Glutaraldehyde 50% is used mainly as a cold disinfectant and as a biocide in off-shore oil operations. Glutaraldehyde 50% is a colorless, oily liquid with a sharp, pungent odor. Glutaraldehyde 50% is used for industrial, laboratory, agricultural, medical, and some household purposes, primarily for disinfecting and sterilization of surfaces and equipment. For example, it is used in oil and gas recovery operations and pipelines, waste water treatment, x-ray processing, embalming fluid, leather tanning, paper industry, in fogging and cleaning of poultry houses, and as a chemical intermediate in the production of various materials. It may be used in select goods, such as paint and laundry detergent. Usage disinfectant The critical effects /of Glutaraldehyde 50% exposure/ are eye, skin, and respiratory irritation, skin sensitization and occupational asthma. Nose and throat irritation has been observed in humans at vapor concentrations below 0.2 ppm. Occupational asthma has also been reported in workers exposed to dilute solutions of Glutaraldehyde 50% ... Contact dermatitis and eye irritation have been reported in workers using Glutaraldehyde 50% solutions, usually 2% or higher. Skin sensitization has been confirmed in workers using dilute solutions. Application restrictions. Use: paint preservative. Maximum application rate of 100 ppm. Use: medical premises disinfection. Maximum application rate of 0.1% of the active ingredient by weight of material being treated. All Glutaraldehyde 50% once-through cooling tower uses, Glutaraldehyde 50% macrofoulant control uses and all critical medical equipment/instrument uses are cancelled. Critical medical equipment use is defined as use of a pesticide in or on any equipment that comes into contact with bodily fluids. Examples of critical medical equipment/instruments include, but are not limited to hemodyalysis tubing, dental instruments. Glutaraldehyde 50% may discolor on exposure to air. It polymerizes on heating. This chemical is incompatible with strong oxidizing agents. It polymerizes in the presence of water. Strong oxidizers, strong bases [Note: Alkaline solutions of Glutaraldehyde 50% (i.e., activated Glutaraldehyde 50%) react with alcohol, ketones, amines, hydrazines and proteins]. The Agency has completed its assessment of the dietary, occupational, drinking water, and ecological risks associated with the use of pesticide products containing the active ingredient Glutaraldehyde 50%. Based on a review of these data and on public comments on the Agency's assessments for the active ingredient Glutaraldehyde 50%, the Agency has sufficient information on the human health and ecological effects of Glutaraldehyde 50% to make decisions as part of the tolerance reassessment process under FFDCA and reregistration process under FIFRA, as amended by FQPA. The Agency has determined that Glutaraldehyde 50%-containing products are eligible for reregistration provided that: (i) confirmatory data needs are addressed; (ii) the risk mitigation measures outlined in this document are adopted; and (iii) label amendments are made to reflect these measures. ... Based on its evaluation of Glutaraldehyde 50%, the Agency has determined that Glutaraldehyde 50% products, unless labeled and used as specified in this document, would present risks inconsistent with FIFRA. Accordingly, should a registrant fail to implement the risk mitigation measures identified in this document, the Agency may take regulatory action to address the risk concerns from the use of Glutaraldehyde 50%. If all changes outlined in this document are incorporated into the product labels, then all current risks for Glutaraldehyde 50% will be substantially mitigated for the purposes of this determination. Once an Endangered Species assessment is completed, further changes to these registrations may be necessary as explained in Section III of this document. IDENTIFICATION AND USE: Glutaraldehyde 50% is a colorless liquid. It is registered for pesticide use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. It is used as algaecide, bacteriocide and fungicide. Glutaraldehyde 50% is used as a tissue fixative in histology and electron and light microscopy, generally as a 1.5-6% aqueous solution. Glutaraldehyde 50% is used, generally in conjunction with wetting agents, to control viruses and other micro-organisms in fish farming. Glutaraldehyde 50% is allowed as a preservative in cosmetics in Europe at concentrations up to 0.1%. It is not allowed in aerosols and sprays. Glutaraldehyde 50% is a biocide commonly used in a 2% concentration for cold sterilization of surgical and dental equipment. Biocides, such as Glutaraldehyde 50%, are added to eliminate bacterial growth in fracturing fluids. HUMAN EXPOSURE AND TOXICITY: Exposure to concentrations < 1 ppm by inhalation or skin contact may cause irritation of the skin and/or mucous membranes. The critical effects of Glutaraldehyde 50% exposure are eye, skin, and respiratory irritation, skin sensitization and occupational asthma. Nose and throat irritation has been observed in humans at vapor concentrations below 0.2 ppm. Occupational asthma has also been reported in workers exposed to dilute solutions of Glutaraldehyde 50%. Contact dermatitis and eye irritation have been reported in workers using Glutaraldehyde 50% solutions, usually 2% or higher. Skin sensitization has been confirmed in workers using dilute solutions. Other symptoms that may be brought on by Glutaraldehyde 50% exposure include heart palpitations and tachycardia. The incidence of death and incidence of cancer deaths in 186 male employees at a Glutaraldehyde 50% production unit were compared to those of US white males and to 29,000 other chemical workers during the period 1959 - 1978. All subjects were observed for 10 yr. The number of deaths was less than expected, as was the incidence of cancer deaths. ANIMAL STUDIES: Glutaraldehyde 50% was corrosive to the skin and eyes of rabbits at high concentrations, with signs of skin irritation evident at 2%, and eye irritation at 0.2%. In an inhalation study where mice were exposed to Glutaraldehyde 50% at concentrations of 33 or 133 ppb for 24 hours, the animals exhibited panting and increased grooming, mice that inhaled the highest concentration developed toxic hepatitis. Following a single whole-body inhalation exposure at 1 ppm for 1 day, rats and mice developed coagulation pathology of the upper respiratory tract squamous epithelium. After 4 days of such exposures, inflammatory granulocytic infiltrate into the squamous epithelium and lamina propria with thickened epithelium of the nasal lumen ensued. In those animals inhaling 0.5 or 1 ppm Glutaraldehyde 50% for four days, the nasal passages became obstructed with intraluminal debris; degenerative/hyperplastic erosions with epithelial abscesses extended as far as the nasopharyngeal meatus in the 1-ppm exposure group. A study of male and female rats given Glutaraldehyde 50% in drinking water at concentrations of 0, 50, 250, or 100 ppm through two generations indicated a dose-related decrease in parental water consumption and body weight (attributed to adverse taste) and decrease in offspring (1000-ppm group) body weights. No adverse reproductive effects were observed. In other study there was a significant dose-dependent reduction in the average of maternal body weight gain and a significant increase in the number of stunted (body weight) and malformed fetuses at the 5 mL/mg/day dose level. Early mutagenicity studies were negative, but more recent studies have indicated that Glutaraldehyde 50% is mutagenic in vitro in bacterial assays and tests in mammalian cells. In vivo genotoxicity tests to date have proven negative. Groups of 50 male and 50 female rats and mice were exposed to Glutaraldehyde 50% vapor at concentrations of 0, 0.25, 0.50, or 0.75 (rats) and 0, 0.062, 0.12, or 0.25 ppm (mice) 6 hr/day, 5 days /week. The incidences of non-neoplastic lesions of the nose were reported to be significantly increased in the 0.50 and 0.75-ppm exposed rats and in the 0.12 and 0.25-ppm exposed male and female mice. ECOTOXICITY STUDIES: Available chronic toxicity data for Glutaraldehyde 50% indicate that continuous exposure results in measurable effects on coldwater fish at a concentration of 5.1 mg a.i./L. A second study on coldwater fish resulted in measurable effects at 2.5 mg a.i./L. Measurable effects on freshwater invertebrates were noted at concentrations of 8.5 mg/L product and 4.9 mg a.i./L. /LABORATORY ANIMALS: Acute Exposure/ Occluded contact /in rabbit/ with 50% Glutaraldehyde 50% solutions in water. Two products tested: Ucarcide 250 and BASF 50% Glutaraldehyde 50%. Severity of irritation was dependent on the duration of contact. Application of 50% Glutaraldehyde 50% for 60 min caused severe irritation and necrosis; 3 min produced transient minor irritation and some discoloration of the skin. In genetic toxicity studies, Glutaraldehyde 50% was mutagenic with and without S9 metabolic activation in S. typhimurium strains TA100, TA102, and TA104. Glutaraldehyde 50% was mutagenic in mouse L5178Y lymphoma cells in the absence of S9 and induced sister chromatid exchanges in cultured Chinese hamster ovary cells with and without S9. No increase in chromosomal aberrations was induced by Glutaraldehyde 50% in cultured Chinese hamster ovary cells with or without S9 at one laboratory; at another laboratory, chromosomal aberrations were induced in the absence of S9 only. Glutaraldehyde 50% did not induce sex-linked recessive lethal mutations in germ cells of male /Drosophila/ melanogaster treated as adults by feeding or injection or treated as larvae by feeding. In vivo, Glutaraldehyde 50% induced a significant increase in chromosomal aberrations in mouse bone marrow cells 36 hr after a single intraperitoneal injection. In a subset of the 36 hr chromosomal aberrations test, there was a small increase in the number of micronucleated bone marrow polychromatic erythrocytes, which was judged to be equivocal. Additional short-term (3 day) and subchronic (13 week) micronucleus tests in mice, using the intraperitoneal or inhalation routes, respectively, yielded negative results. Glutaraldehyde 50%'s production and use as a disinfectant, as a cross-linking agent, as a tanning agent for leather and use in the paper and textile industries to improve wet strength and dimensional stability of fibers may result in its release to the environment through various waste streams. Its use as a biocide in water treatment, hydraulic fracturing fluids and oil-field applications and as a preservative in cosmetics and personal-care products will result in its direct release to the environment. Glutaraldehyde 50% has been detected in gasoline and diesel engine emissions. If released to air, a vapor pressure of 0.6 mm Hg at 30 °C indicates Glutaraldehyde 50% will exist solely as a vapor in the atmosphere. Vapor-phase Glutaraldehyde 50% will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 16 hours. Glutaraldehyde 50% may be susceptible to direct photolysis in the atmosphere based upon aqueous photolysis studies. If released to soil, Glutaraldehyde 50% is expected to have very high to moderate mobility based upon measured Koc values ranging from 5.1 to 500. Volatilization from moist soil surfaces is not expected to be an important fate process based upon a Henry's Law constant of 3.3X10-8 atm-cu m/mole. Glutaraldehyde 50% is expected to volatilize from dry soil surfaces based upon its vapor pressure and it has been reported that small amounts of Glutaraldehyde 50% will volatilize to the atmosphere. Results of biodegradation screening tests indicate that Glutaraldehyde 50% is readily biodegradable. A soil degradation study using a loamy sand soil observed a pseudo-first order dissipation half-life of 1.7 days due primarily to soil microorganisms. If released into water, Glutaraldehyde 50% is not expected to adsorb to suspended solids and sediment based upon the Koc. In a closed bottle test using seawater as inoculum, Glutaraldehyde 50% showed 73% degradation in 28 days indicating that biodegradation is expected to be an important fate process in water. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. At 25 °C, Glutaraldehyde 50% has measured hydrolysis half-lives of 508-628, 102-394 and 46-63.8 days at pH 5, pH 7 and pH 9 respectively. The measured half-life for the photolysis of aqueous solutions of Glutaraldehyde 50% exposed to natural sunlight was 196 days. Occupational exposure to Glutaraldehyde 50% may occur through inhalation and dermal contact with this compound at workplaces where Glutaraldehyde 50% is produced or used. Use and limited monitoring data indicate that the general population may be exposed to Glutaraldehyde 50% via inhalation of ambient air and dermal contact with consumer products containing Glutaraldehyde 50%. TERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values ranging from 5.1 to 500(2,3) indicate that Glutaraldehyde 50% is expected to have very high to moderate mobility in soil(SRC). Volatilization of Glutaraldehyde 50% from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 3.3X10-8 atm-cu m/mole(2). Glutaraldehyde 50% is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.6 mm Hg at 30 °C(4), and it has been reported that small amounts of Glutaraldehyde 50% will volatilize to the atmosphere(4). Results of biodegradation screening tests indicate that Glutaraldehyde 50% is readily biodegradable(2,3,5). A soil degradation study using a loamy sand soil and and initial Glutaraldehyde 50% concentration of 10 ppm observed a pseudo-first order dissipation half-life of 1.7 days due primarily to soil microorganisms(3). AQUATIC FATE: Based on a classification scheme(1), measured Koc values ranging from 5.1 to 500(2,3) indicate that Glutaraldehyde 50% is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 3.3X10-8 atm-cu m/mole(2). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of -0.33(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Results of biodegradation screening tests indicate that Glutaraldehyde 50% is readily biodegradable(2,3,7). In a closed bottle test using seawater as inoculum, Glutaraldehyde 50% showed 73% degradation in 28 days(2). At 25 °C, Glutaraldehyde 50% has measured hydrolysis half-lives of 508-628, 102-394 and 46-63.8 days at pH 5, pH 7 and pH 9 respectively(2,3). The measured half-life for the photolysis of sterile aqueous solutions of Glutaraldehyde 50% exposed to natural sunlight was 196 days(2). ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), Glutaraldehyde 50%, which has a vapor pressure of 0.6 mm Hg at 30 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase Glutaraldehyde 50% is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 2.52X10-11 cu cm/molecule-sec at 25 °C(3). Aqueous solutions of Glutaraldehyde 50% have an observed photolysis half-life of 196 days when exposed to sunlight(4) suggesting that direct photolysis may occur in the ambient atmosphere(SRC). AEROBIC: Glutaraldehyde 50%, present at 100 mg/L, reached 59% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Using OECD Guideline 301C (Ready biodegradability: Modified MITI Test (I)), Glutaraldehyde 50% reached 74% of its theoretical BOD in 28 days and 80% DOC in 15 days with classified the compound as readily biodegradable(2). Glutaraldehyde 50% was found to be readily biodegradable using OECD Guideline 301D (Closed Bottle Test)(2). In a DOC die-away test, glutaradehyde, present at 25 mg/L, showed 83% degradation in 5 days using a sewage inoculum(3). Glutaraldehyde 50%, present at 8.3 mg/L, degraded 60% in 28 days using sewage inoculum in a CO2 evolution test(3). In a closed bottle test, Glutaraldehyde 50% present at 2.0 mg/L, degraded 64% in 28 days using a Polyseed inoculum(3). A higher biodegradability with a short lag time was observed when the Glutaraldehyde 50% concentrations in the test systems were low (<2 mg/L) than when the concentrations were high (>8 mg/L). Since bacterial inhibition for Glutaraldehyde 50% occurs at about 5 mg/L, the lower biodegradation rates observed in studies where high concentrations of Glutaraldehyde 50% were used were likely due to inhibition of the inoculum(3). In a closed bottle test using seawater as inoculum, Glutaraldehyde 50% showed 73% degradation in 28 days(3). The major metabolite of Glutaraldehyde 50% produced by microbes in an aerobic sediment-river water system was carbon dioxide, with glutaric acid formed as an intermediate in the water phase(3). The calculated pseudo-first-order half-life of Glutaraldehyde 50% catabolism in water (based on the loss of the parent compound) under aerobic conditions was 10.6 hours(3). A soil degradation study using a loamy sand soil and initial Glutaraldehyde 50% concentration of 10 ppm observed a pseudo-first order biodegradation half-life of 1.7 days due primarily to soil microorganisms(4). ANAEROBIC: The major metabolites of Glutaraldehyde 50% produced by microbes in an anaerobic sediment-river water system were 1,5-pentanediol with 5-hydroxypentanal formed as an intermediate, and 3-formyl-6-hydroxy-2-cyclohexene-1-propanal, a cyclicized dimer of Glutaraldehyde 50%. The calculated pseudo-first-order half-life of Glutaraldehyde 50% catabolism in water (based on the loss of the parent compound) under anaerobic conditions was 7.7 hours(1). The rate constant for the vapor-phase reaction of Glutaraldehyde 50% with photochemically-produced hydroxyl radicals has been measured as 2.52X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 15 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). The measured first-order rate constants of the hydrolysis of Glutaraldehyde 50% at pH 5 and 7 were 0.0014 and 0.0068 per day (at 25 °C), which corresponds to half-lives of 508 and 102 days, respectively(3). At pH 9, the first-order rate constant was measured to be 0.015 per day, corresponding to a half-life of 46 days(4). The only major degradate observed and identified was a cyclized dimer of Glutaraldehyde 50%, 3-formyl-6-hydroxy-2-cyclohexene-1-propanal(3). Hydrolysis tests conducted at 40 and 50 °C and pH 9 for 165 hours determined the hydrolysis half-life is >24 hours at 50 °C and >59 hours at 40 °C(4). An hydrolysis test according to OECD Guideline 111 (Hydrolysis as a Function of pH) reported Glutaraldehyde 50% to be hydrolytically stable at pH 4 and pH 7 with decomposition at pH 9(4). At 25 °C, hydrolysis half-lives were 628, 394 and 63.8 days respectively at pH 5, pH 7 and pH 9(4). The measured first-order rate constant for the photolysis of sterile aqueous solutions of Glutaraldehyde 50% exposed to natural sunlight was 0.0035 per day with a corresponding half life was 196 days(3). The Henry's Law constant for Glutaraldehyde 50% has been experimentally determined to be 3.30X10-8 atm-cu m/mole(1). This Henry's Law constant indicates that Glutaraldehyde 50% is expected to be essentially nonvolatile from water surfaces(2). Glutaraldehyde 50%'s Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Glutaraldehyde 50% is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.6 mm Hg(3), and
GLUTARIC ACID
Glutaric Acid Glutaric acid (glutarik asit) is a simple five-carbon linear dicarboxylic acid. Glutaric acid (glutarik asit) is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. Glutaric acid (glutarik asit) may cause irritation to the skin and eyes. When present in sufficiently high levels, Glutaric acid (glutarik asit) can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of Glutaric acid (glutarik asit) are associated with at least three inborn errors of metabolism, including Glutaric acid (glutarik asit)uria type I, malonyl-CoA decarboxylase deficiency, and Glutaric acid (glutarik asit)uria type III. Glutaric acid (glutarik asit)uria type I (Glutaric acid (glutarik asit)emia type I, glutaryl-CoA dehydrogenase deficiency, GA1, or GAT1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine, and tryptophan due to a deficiency of mitochondrial glutaryl-CoA dehydrogenase (EC 1. 3. 99. 7, GCDH). Excessive levels of their intermediate breakdown products (e. g. Glutaric acid (glutarik asit), glutaryl-CoA, 3-hydroxyGlutaric acid (glutarik asit), glutaconic acid) can accumulate and cause damage to the brain (and also other organs). Babies with Glutaric acid (glutarik asit)emia type I are often born with unusually large heads (macrocephaly). Macrocephaly is amongst the earliest signs of GA1. GA1 also causes secondary carnitine deficiency because Glutaric acid (glutarik asit), like other organic acids, is detoxified by carnitine. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7. 35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of untreated Glutaric acid (glutarik asit)uria. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. Treatment of Glutaric acid (glutarik asit)uria is mainly based on the restriction of lysine intake, supplementation of carnitine, and an intensification of therapy during intercurrent illnesses. The major principle of dietary treatment is to reduce the production of Glutaric acid (glutarik asit) and 3-hydroxyGlutaric acid (glutarik asit) by restriction of natural protein, in general, and of lysine, in particular (PMID: 17465389, 15505398). Production of Glutaric acid (glutarik asit) Glutaric acid (glutarik asit) can be prepared by the ring-opening of butyrolactone with potassium cyanide to give the mixed potassium carboxylate-nitrile that is hydrolyzed to the diacid.[1] Alternatively hydrolysis, followed by oxidation of dihydropyran gives Glutaric acid (glutarik asit). It can also be prepared from reacting 1,3-dibromopropane with sodium or potassium cyanide to obtain the dinitrile, followed by hydrolysis. Uses of Glutaric acid (glutarik asit) 1,5-Pentanediol, a common plasticizer and precursor to polyesters is manufactured by hydrogenation of Glutaric acid (glutarik asit) and its derivatives.[2] Glutaric acid (glutarik asit) itself has been used in the production of polymers such as polyester polyols, polyamides. The odd number of carbon atoms (i.e. 5) is useful in decreasing polymer elasticity.[citation needed] Uvitonic acid is obtained by the action of ammonia on Glutaric acid (glutarik asit). Safety Glutaric acid (glutarik asit) may cause irritation to the skin and eyes.[3] Acute hazards include the fact that this compound may be harmful by ingestion, inhalation or skin absorption. Application of Glutaric acid (glutarik asit) Glutaric acid (glutarik asit) may be employed as starting reagent in the synthesis of glutaric anhydride. Glutaric acid (glutarik asit) may be used for the following studies: • Complexation with DL-lysine. Complexes have been reported to possess zwitterionic lysinium ions (positively charged) and semi-glutarate ions (negatively charged).[8] • Synthesis of complexes with L-arginine and L-histidine.[7] • Preparation of glycine-Glutaric acid (glutarik asit) co-crystals. Phase transition studies of these cocrystals have been reported by single-crystal X-ray diffraction, polarized Raman spectroscopy and differential scanning calorimetry.[1] General description Glutaric acid (glutarik asit) (Pentanedioic Acid) is a linear dicarboxylic acid. It has been prepared by oxidizing cyclopentane, cyclopentanol and cyclopentanone.[9] Glutaric acid (glutarik asit) is a pentanedioic acid. On exposure to X-rays, Glutaric acid (glutarik asit) crystals generate two stable free radicals. These free radicals have been investigated by electron nuclear double resonance (ENDOR) technique.[5] Presence of Glutaric acid (glutarik asit) in urine and plasma is an indicator of type I Glutaric acid (glutarik asit)uria (GA-I).[6] Glutaric acid (glutarik asit) is formed as an intermediate during the catabolism of lysine in mammals.[3] Electron spin resonance spectra of radical (CO2H)CH2CH2CH(CO2H formed in Glutaric acid (glutarik asit) crystal after γ-irradiation is reported to remains trapped in it.[2] Polymorphism of Glycine-Glutaric acid (glutarik asit) co-crystals has been studied by single crystal X-ray diffraction and Raman spectroscopy.[4] Low-temperature phase transition in glycine-Glutaric acid (glutarik asit) co-crystals studied by single-crystal X-ray diffraction, Raman spectroscopy and differential scanning calorimetry. Glutaric acid (glutarik asit) Glutaric acid (glutarik asit)uria type 1 (OMIM #231670) due to glutaryl-coenzyme A dehydrogenase deficiency is associated with accumulation of Glutaric acid (glutarik asit), glutaryl carnitine, and secondary metabolites in body fluids. The clinical picture is variable. Most patients are macrocephalic. The authors selected the Glutaric acid (glutarik asit) cocrystal2 for further evaluation because of the relatively high melting point of the cocrystal and the expected high water solubility of the cocrystal because of the high water solubility of the coformer. A solvent-based Glutaric acid (glutarik asit)uria Type 1 (OMIM 231670) The metabolism of lysine, hydroxylsine, and tryptophan is disrupted secondary to deficiency in glutaryl-CoA dehydrogenase, a mitochondrial enzyme. This results in the accumulation of Glutaric acid (glutarik asit) and 3-hydroxyGlutaric acid (glutarik asit). Investigation Neuroimaging is characteristic, with frontotemporal atrophy and often subdural effusions or hematomas. This may lead to initial suspicion of child abuse. There is excessive glutaric and 3-hydroxyGlutaric acid (glutarik asit) in the urine. Plasma free carnitine is reduced and glutaryl carnitine is elevated. Reduced enzyme activity is demonstrated in fibroblasts. Urine organic acid analysis detects a wide range of compounds. It is an excellent diagnostic test for the organic acidemias involving propionic, methylmalonic, and isovaleric acids. It also detects Glutaric acid (glutarik asit), which is a progressive neurotoxic defect in biomolecule conversion. The fatty acid oxidation defects also result in abnormal compounds in the urine. The presence of succinylacetone is a hallmark of tyrosinemia; similarly, the presence of isoleucine metabolites is a hallmark of maple syrup urine disease. Lactic acid and ketones are also detectable on organic acid analysis but are not always well correlated with plasma levels. Common Name Glutaric acid (glutarik asit) Class Small Molecule Description Glutaric acid (glutarik asit) is a simple five-carbon linear dicarboxylic acid. Glutaric acid (glutarik asit) is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. Glutaric acid (glutarik asit) may cause irritation to the skin and eyes. When present in sufficiently high levels, Glutaric acid (glutarik asit) can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of Glutaric acid (glutarik asit) are associated with at least three inborn errors of metabolism, including Glutaric acid (glutarik asit)uria type I, malonyl-CoA decarboxylase deficiency, and Glutaric acid (glutarik asit)uria type III. Glutaric acid (glutarik asit)uria type I (Glutaric acid (glutarik asit)emia type I, glutaryl-CoA dehydrogenase deficiency, GA1, or GAT1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine, and tryptophan due to a deficiency of mitochondrial glutaryl-CoA dehydrogenase (EC 1.3.99.7, GCDH). Excessive levels of their intermediate breakdown products (e.g. Glutaric acid (glutarik asit), glutaryl-CoA, 3-hydroxyGlutaric acid (glutarik asit), glutaconic acid) can accumulate and cause damage to the brain (and also other organs). Babies with Glutaric acid (glutarik asit)emia type I are often born with unusually large heads (macrocephaly). Macrocephaly is amongst the earliest signs of GA1. GA1 also causes secondary carnitine deficiency because Glutaric acid (glutarik asit), like other organic acids, is detoxified by carnitine. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to h ...Read more Mechanism of Toxicity Accumulation of Glutaric acid (glutarik asit) in the body has been shown to be toxic. The accumulation of Glutaric acid (glutarik asit) ranging from slightly or intermittently elevated urinary Glutaric acid (glutarik asit) to gross organic aciduria occurs in Glutaric acid (glutarik asit)uria. Glutaric acid (glutarik asit)uria type 1 is an autosomal-recessive disorder resulting from a deficiency of mitochondrial glutaryl-CoA dehydrogenase which is involved in the metabolism of lysine, hydroxylysine, Uses/Sources This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation. Minimum Risk Level Not Available Health Effects Chronically high levels of Glutaric acid (glutarik asit) are associated with at least 3 inborn errors of metabolism including: Glutaric acid (glutarik asit)uria Type I and Glutaric acid (glutarik asit)uria Type III. Clinical Information Acylcarnitine analysis is included in newborn screening blood testing and is utilized for detection of several inborn errors of metabolism, including fatty acid oxidation disorders (FAOD) and organic acidemias (OA). A limitation of this analytic method is its inability to differentiate between several isomers. Additional testing of 2-hydroxy Glutaric acid (glutarik asit) (2OH-GA), 3-hydroxy Glutaric acid (glutarik asit) (3OH-GA), Glutaric acid (glutarik asit) (GA), methylsuccinic acid (MSA), and ethylmalonic acid (EMA) by LC-MS/MS allows better differentiation among C4-acylcarnitine and glutarylcarnitine/C10-OH isomers. Glutarylcarnitine (C5-DC) is elevated in Glutaric acid (glutarik asit)emia type 1 (GA-1), but is not differentiated from C10-OH acylcarnitine. GA-1, is caused by a deficiency of glutaryl-CoA dehydrogenase and is characterized by bilateral striatal brain injury leading to dystonia, often a result of acute neurologic crises triggered by illness. Individuals with GA-1 typically show elevations of Glutaric acid (glutarik asit) and 3OH-GA, even in those considered to be "low excretors." Glutaric acid (glutarik asit) Class Small Molecule Description Glutaric acid (glutarik asit) is a simple five-carbon linear dicarboxylic acid. Glutaric acid (glutarik asit) is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. Glutaric acid (glutarik asit) may cause irritation to the skin and eyes. When present in sufficiently high levels, Glutaric acid (glutarik asit) can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of Glutaric acid (glutarik asit) are associated with at least three inborn errors of metabolism, including Glutaric acid (glutarik asit)uria type I, malonyl-CoA decarboxylase deficiency, and Glutaric acid (glutarik asit)uria type III. Glutaric acid (glutarik asit)uria type I (Glutaric acid (glutarik asit)emia type I, glutaryl-CoA dehydrogenase deficiency, GA1, or GAT1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine, and tryptophan due to a deficiency of mitochondrial glutaryl-CoA dehydrogenase (EC 1.3.99.7, GCDH). Excessive levels of their intermediate breakdown products (e.g. Glutaric acid (glutarik asit), glutaryl-CoA, 3-hydroxyGlutaric acid (glutarik asit), glutaconic acid) can accumulate and cause damage to the brain (and also other organs). Babies with Glutaric acid (glutarik asit)emia type I are often born with unusually large heads (macrocephaly). Macrocephaly is amongst the earliest signs of GA1. GA1 also causes secondary carnitine deficiency because Glutaric acid (glutarik asit), like other organic acids, is detoxified by carnitine. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to h ...Read more DRUG INTERACTION Acetazolamide The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Acetazolamide. Acetylsalicylic acid The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Acetylsalicylic acid. Acyclovir The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Acyclovir. Adefovir dipivoxil The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Adefovir dipivoxil. Allopurinol The excretion of Allopurinol can be decreased when combined with Glutaric acid (glutarik asit). Alprostadil The excretion of Alprostadil can be decreased when combined with Glutaric acid (glutarik asit). Aminohippuric acid The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Aminohippuric acid. Aminophenazone The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Aminophenazone. Amoxicillin The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Amoxicillin. Antipyrine The excretion of Glutaric acid (glutarik asit) can be decreased when combined with Antipyrine. A limitation of this analytic method is its inability to differentiate between several isomers. Additional testing of 2-hydroxy Glutaric acid (glutarik asit) (2OH-GA), 3-hydroxy Glutaric acid (glutarik asit) (3OH-GA), Glutaric acid (glutarik asit) (GA), methylsuccinic acid (MSA), and ethylmalonic acid (EMA) by LC-MS/MS allows better differentiation among C4-acylcarnitine and glutarylcarnitine/C10-OH isomers. Glutarylcarnitine (C5-DC) is elevated in Glutaric acid (glutarik asit)emia type 1 (GA-1), but is not differentiated from C10-OH acylcarnitine. GA-1, is caused by a deficiency of glutaryl-CoA dehydrogenase and is characterized by bilateral striatal brain injury leading to dystonia, often a result of acute neurologic crises triggered by illness. Individuals with GA-1 typically show elevations of Glutaric acid (glutarik asit) and 3OH-GA, even in those considered to be "low excretors." Glutaric acid (glutarik asit)emia (GA-2), also known as multiple acyl-CoA dehydrogenase deficiency (MADD), is caused by defects in either the electron transfer flavoprotein (ETF) or ETF-ubiquinone oxidoreductase. This disease can be severe and is often fatal in the first weeks of life, with typical symptoms of hypoglycemia, muscle weakness, metabolic acidosis, dysmorphic features, cardiac defects or arrhythmias, renal cysts, and fatty infiltration of the liver. GA-2 can have a milder presentation, also known as ethylmalonic-adipic aciduria, with Reye-like illnesses in childhood and muscle weakness in childhood and adulthood. In addition to elevations in Glutaric acid (glutarik asit), individuals with GA-2 can also show increased EMA, MSA, and 2OH-GA. Reference Values 2-OH Glutaric acid (glutarik asit): < or =25 nmol/mL 3-OH Glutaric acid (glutarik asit): < or =1.5 nmol/mL Glutaric acid (glutarik asit): < or =1.5 nmol/mL Methylsuccinic acid: < or =0.45 nmol/mL Ethylmalonic acid: < or =3.5 nmol/mL Normal levels of EMA in the context of elevated C4 is consistent with a diagnosis of isobutyryl-CoA dehydrogenase (IBDH) deficiency. Elevation of Glutaric acid (glutarik asit) (GA) and 3-hydroxy Glutaric acid (glutarik asit) (3OH-GA) are consistent with a diagnosis of Glutaric acid (glutarik asit)emia type 1 (GA-1). Elevation of GA, 2-hydroxy Glutaric acid (glutarik asit) (2OH-GA), 3OH-GA, EMA, and MSA are consistent with a diagnosis of Glutaric acid (glutarik asit)emia (GA-2). 2. Kolker S, Christensen E, Leonar JV, et al: Diagnosis and management of Glutaric acid (glutarik asit)uria type I-revised recommendations. J Inherit Metab Dis 2011;34:677-694 3. Frerman FE, Goodman SI: Chapter 103: Defects of electron transfer flavoprotein and electron transfer flavoprotein-ubiquinone oxidoreductase: Glutaric acid (glutarik asit)emia Type II. In Scriver's Online Metabolic and Molecular Bases of Inherited Disease. Edited by CR Scriver, AL Beaudet, D Valle, et al. Accessed 8/17/17. Available at Glutaric acid (glutarik asit)uria Type I 1) Glutaric acid (glutarik asit)uria IIA (GA IIA) is the neonatal form of glutaricaciduria II. This form of Glutaric acid (glutarik asit)uria II is a very rare, X-linked hereditary disorder characterized by large amounts of glutaric and other acids in blood and urine. The disorder is caused by dysfunction of the electron-transferring flavoprotein in the mitochondria. 2) Glutarica aciduria IIB (GA IIB; ethylmalonic adipicaciduria) is the adult form of glutaricaciduria II. This milder form of the disorder is inherited in an autosomal recessive pattern. Acidity of the body tissues (metabolic acidosis), and a low blood sugar level (hypoglycemia) without an elevated level of ketones in body tissues (ketosis), occur during adulthood. Large amounts of Glutaric acid (glutarik asit) in the blood and urine are caused by a deficiency of the enzyme multiple acyl-CoA dehydrogenase. (For more information on this disorder, choose "Glutaric acid (glutarik asit)uria II" as your search term in the Rare Disease Database.) Glutaric acid (glutarik asit)uria III is an autosomal recessive genetic condition characterized by accumulation or excretion of Glutaric acid (glutarik asit) and caused by mutations in the C7ORF10 gene. Symptoms vary and some individuals show no symptoms Goodman SI, Frerman FE. Organic acidemias due to defects in lysine oxidation: 2-ketoadipic acidemia and Glutaric acid (glutarik asit)emia. In: Scriver CR, Beaudet AL, Sly WS, et al. Eds. The Metabolic Molecular Basis of Inherited Disease. 7th ed. McGraw-Hill Companies. New York, NY; 1995:1451-60. 3.6. Effect of Glutaric acid (glutarik asit) on Caspase 3 Transcript and Protein Levels Quantitative RT-PCR was performed to monitor mRNA expression of the apoptotic executioner caspase 3 (Figure 9(a)). The comparative method was used to analyse relative expression levels. Caspase 3 mRNA expression at 6 hours after treatment with 1, 10, 25, and 50 mM GA was upregulated about 1.40-fold, 1.67-fold, and 1.95-fold, respectively, compared to control. Thus GA might induce apoptosis via caspase 3 activation. 4. Discussion Glutaric acid (glutarik asit)uria type I is an autosomal recessive disorder characterized by high levels of GA, 3-hydroxyGlutaric acid (glutarik asit) (3-OHGA), glutaconic acid, and glutaryl-CoA in body fluids as well as degenerative changes in the striatal and frontotemporal cortical neurons. A deficiency of cerebral GCDH activity is attributed to the development of neurological damage in GA I patients. However, the comprehension of the degeneration mechanism in the basal ganglia still remains partial. Glutaric acid (glutarik asit) is the organic compound with the formula C3H6(COOH)2 . Although the related "linear" dicarboxylic acids adipic and succinic acids are water-soluble only to a few percent at room temperature, the water-solubility of Glutaric acid (glutarik asit) is over 50% (w/w). Glutaric acid (glutarik asit) is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. Defects in this metabolic pathway can lead to a disorder called Glutaric acid (glutarik asit)uria, where toxic byproducts build up and can cause severe encephalopathy. Glutaric acid (glutarik asit) can be prepared by the ring-opening of butyrolactone with potassium cyanide to give the mixed potassium carboxylate-nitrile that is hydrolyzed to the diacid.[1] Alternatively hydrolysis, followed by oxidation of dihydropyran gives Glutaric acid (glutarik asit). It can also be prepared from reacting 1,3-dibromopropane with sodium or potassium cyanide to obtain the dinitrile, followed by hydrolysis. 1,5-Pentanediol, a common plasticizer and precursor to polyesters is manufactured by hydrogenation of Glutaric acid (glutarik asit) and its derivatives.[2] Glutaric acid (glutarik asit) itself has been used in the production of polymers such as polyester polyols, polyamides. The odd number of carbon atoms (i.e. 5) is useful in decreasing polymer elasticity.[citation needed] Uvitonic acid is obtained by the action of ammonia on Glutaric acid (glutarik asit). Glutaric acid (glutarik asit) may cause irritation to the skin and eyes.[3] Acute hazards include the fact that this compound may be harmful by ingestion, inhalation or skin absorption.[3] Glutaric acid (glutarik asit) (Pentanedioic Acid) is a linear dicarboxylic acid. It has been prepared by oxidizing cyclopentane, cyclopentanol and cyclopentanone.[9] Glutaric acid (glutarik asit) is a pentanedioic acid. On exposure to X-rays, Glutaric acid (glutarik asit) crystals generate two stable free radicals. These free radicals have been investigated by electron nuclear double resonance (ENDOR) technique.[5] Presence of Glutaric acid (glutarik asit) in urine and plasma is an indicator of type I Glutaric acid (glutarik asit)uria (GA-I). Glutaric acid (glutarik asit) is formed as an intermediate during the catabolism of lysine in mammals.[3] Electron spin resonance spectra of radical (CO2H)CH2CH2CH(CO2H formed in Glutaric acid (glutarik asit) crystal after γ-irradiation is reported to remains trapped in it.[2] Polymorphism of Glycine-Glutaric acid (glutarik asit) co-crystals has been studied by single crystal X-ray diffraction and Raman spectroscopy.[4] Application of Glutaric acid (glutarik asit) Glutaric acid (glutarik asit) may be employed as starting reagent in the synthesis of glutaric anhydride.[9] Glutaric acid (glutarik asit) is a simple five-carbon linear dicarboxylic acid. Glutaric acid (glutarik asit) is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. Glutaric acid (glutarik asit) may cause irritation to the skin and eyes. When present in sufficiently high levels, Glutaric acid (glutarik asit) can act as an acidogen and a metabotoxin. Chronically high levels of Glutaric acid (glutarik asit) are associated with at least three inborn errors of metabolism, including Glutaric acid (glutarik asit)uria type I Glutaric acid (glutarik asit) is the organic compound with the formula C3H6(COOH)2 . Although the related "linear" dicarboxylic acids adipic and succinic acids are water-soluble only to a few percent at room temperature, the water-solubility of Glutaric acid (glutarik asit) is over 50% (w/w). Glutaric acid (glutarik asit) has the lowest melting point among dicarboxylic acids (98 C); it is very soluble in water and the solution in water is a medium strong acid. Short-term exposure to Glutaric acid (glutarik asit) may cause irritation to the eyes, skin and the respiratory tract.
GLUTARIC ACID
Glutaric acid is a linear dicarboxylic acid. 
On exposure to X-rays, glutaric acid crystals generate two stable free radicals. 
Glutaric acid is formed as an intermediate during the catabolism of lysine in mammals. 

CAS Number: 110-94-1
EC Number: 203-817-2
Chemical formula: C5H8O4
Molar mass: 132.12 g/mol

GLUTARIC ACID, Pentanedioic acid, 110-94-1, 1,5-Pentanedioic acid, glutarate, 1,3-Propanedicarboxylic acid, Pentandioic acid, n-Pyrotartaric acid, propane-1,3-dicarboxylic acid, UNII-H849F7N00B, CHEBI:17859, MFCD00004410, Carboxylic acids, C6-18 and C5-15-di-, NSC9238, H849F7N00B, DSSTox_CID_1654, DSSTox_RID_76266, DSSTox_GSID_21654, CAS-110-94-1, HSDB 5542, NSC 9238, EINECS 203-817-2, BRN 1209725, Glutarsaeure, Pentandioate, AI3-24247, 1czc, 1,5-Pentanedioate, Glutaric acid, 99%, 4lh3, 1,3-Propanedicarboxylate, WLN: QV3VQ, (C4-C6) Dibasic acids, pentanedioate;Glutaric acid, bmse000406, Glutaric Acid and Anhydride, SCHEMBL7414, 4-02-00-01934, Pentanedioic acid Glutaric acid, Carboxylic acids, di-, C4-6, CHEMBL1162495, DTXSID2021654, ZINC388706, NSC-9238, Tox21_202448, Tox21_302871, BDBM50485550, s3152, AKOS000118800, CS-W009536, DB03553, HY-W008820, LS41863, MCULE-4286022994, NCGC00249226-01, NCGC00256456-01, NCGC00259997-01, 68937-69-9, AS-13132, BP-21143, H402, SY029948, FT-0605446, G0069, G0245, C00489, D70283, A802271, Q409622, Glutaric Acid (ca. 50% in Water, ca. 4.3mol/L), J-011915, Q-201163, Z57127454, 78FA13BF-E0C0-4EFC-948C-534CF45044E3, F2191-0242, Glutaric acid, certified reference material, TraceCERT(R), Glutaric acid, 1,3-Propanedicarboxylate, 1,5-Pentanedioate, 1,5-Pentanedioic acid, 110-94-1, 1209725, 203-817-2, Acide glutarique, Glutarsäure, hydrogen glutarate, MFCD00004410, n-Pyrotartaric acid, Pentanedioic acid, 1,3-PROPANEDICARBOXYLIC ACID, 111-16-0, 154184-99-3, 19136-99-3, 203-817-2MFCD00004410, 271-678-5, 273-081-5, 4-02-00-01934, 43087-19-0, 68603-87-2, 68937-69-9, 8065-59-6, Glutaric acid (Pentanedioic acid), glutaric acid, reagent, Gua, hydron, Pentandioate, Pentandioic acid, pentanedioate, Pentanedioic-2,2,4,4-d4 Acid, Pentanedioic-3,3-d2 Acid, Pentanedioic-d6 Acid, Propane-1,3-dicarboxylic acid, Propane-1,3-dicarboxylic acid|Pentanedioic acid,Glutaric acid, WLN: QV3VQ

Glutaric acid (Pentanedioic Acid) is a linear dicarboxylic acid.
Glutaric acid has been prepared by oxidizing cyclopentane, cyclopentanol and cyclopentanone.

Glutaric acid is a pentanedioic acid.
On exposure to X-rays, glutaric acid crystals generate two stable free radicals.

These free radicals have been investigated by electron nuclear double resonance (ENDOR) technique.
Presence of glutaric acid in urine and plasma is an indicator of type I glutaric aciduria (GA-I).

Glutaric acid is formed as an intermediate during the catabolism of lysine in mammals.
Electron spin resonance spectra of radical (CO2H)CH2CH2CH(CO2H formed in glutaric acid crystal after γ-irradiation is reported to remains trapped in Glutaric acid.
Polymorphism of Glycine-glutaric acid co-crystals has been studied by single crystal X-ray diffraction and Raman spectroscopy.

Glutaric acid is a simple five-carbon linear dicarboxylic acid.
Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan.

Glutaric acid may cause irritation to the skin and eyes.
When present in sufficiently high levels, glutaric acid can act as an acidogen and a metabotoxin.

An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems.
A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels.

Chronically high levels of glutaric acid are associated with at least three inborn errors of metabolism, including glutaric aciduria type I, malonyl-CoA decarboxylase deficiency, and glutaric aciduria type III.
Glutaric aciduria type I (glutaric acidemia type I, glutaryl-CoA dehydrogenase deficiency, GA1, or GAT1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine, and tryptophan due to a deficiency of mitochondrial glutaryl-CoA dehydrogenase (EC 1.3.99.7, GCDH).

Excessive levels of their intermediate breakdown products (e.g. glutaric acid, glutaryl-CoA, 3-hydroxyglutaric acid, glutaconic acid) can accumulate and cause damage to the brain (and also other organs).
Babies with glutaric acidemia type I are often born with unusually large heads (macrocephaly).

Macrocephaly is amongst the earliest signs of GA1.
GA1 also causes secondary carnitine deficiency because glutaric acid, like other organic acids, is detoxified by carnitine.

Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis.
Acidosis typically occurs when arterial pH falls below 7.35.

In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy).
These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death.

These are also the characteristic symptoms of untreated glutaric aciduria.
Many affected children with organic acidemias experience intellectual disability or delayed development.

In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures.
Treatment of glutaric aciduria is mainly based on the restriction of lysine intake, supplementation of carnitine, and an intensification of therapy during intercurrent illnesses.

The major principle of dietary treatment is to reduce the production of glutaric acid and 3-hydroxyglutaric acid by restriction of natural protein, in general, and of lysine, in particular.
Glutaric acid has also been found in Escherichia

Glutaric acid is an alpha,omega-dicarboxylic acid which has simple 5 carbon linear dicarboxylic acid (HO2C−R−CO2H).
The molecular or chemical formula of Glutaric acid is C5H8O4.

When pentanedioic acid is present in a high amount Glutaric acid acts as a metabotoxin and as an acidogen.
Glutaric acid can be synthesized by the following process

The ring-opening of butyrolactone (C4H6O2) with potassium cyanide (KCN) to produce potassium carboxylate-nitrile.
Glutaric acid is hydrolyzed further to diacid.

Oxidizing dihydropyran will produce glutaric acid.
Glutaric acid can also be synthesized by treating 1,3-dibromopropane with potassium or sodium cyanide to produce dinitrile.
Further, Glutaric acid is hydrolysed to obtain glutaric acid.

Glutaric acid is used as the raw material for organic synthesis, pharmaceutical intermediate and synthetic resin.
Glutaric acid serves as a precursor in the production of polyester polyols, polyamides, ester plasticizers and corrosion inhibitors.

Glutaric acid is useful to decrease polymer elasticity and in the synthesis surfactants and metal finishing compounds.
Glutaric acid acts as an intermediate during the catabolism of lysine in mammals.

Glutaric acid, also known as 1,5-pentanedioate or pentanedioic acid, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.
These are organic compounds containing exactly two carboxylic acid groups.

Glutaric acid exists in all living organisms, ranging from bacteria to humans.
Glutaric acid is an odorless tasting compound.

Glutaric acid has been detected, but not quantified in, several different foods, such as eddoes (Colocasia antiquorum), pitangas (Eugenia uniflora), narrowleaf cattails (Typha angustifolia), chicory leaves (Cichorium intybus var. foliosum), and wax apples (Eugenia javanica).
This could make glutaric acid a potential biomarker for the consumption of these foods.
Glutaric acid, with regard to humans, has been found to be associated with several diseases such as eosinophilic esophagitis and irritable bowel syndrome; glutaric acid has also been linked to several inborn metabolic disorders including glutaric aciduria I, 3-hydroxy-3-methylglutaryl-coa lyase deficiency, and short chain acyl-coa dehydrogenase deficiency.

Glutaric acid is a dinucleotide phosphate that exists in two forms: the alpha form, which has a high phase transition temperature and is insoluble in water; and the beta form, which has a low phase transition temperature and is soluble in water.
Glutaric acid can be used as an analytical reagent to identify the type of nucleotides present in samples.

Glutaric acid can also be used as an experimental solvent for other compounds that are not soluble in water.
The toxicity of glutaric acid has been studied extensively and found to be low.

This compound does not appear to have any adverse effects on human health or animals at doses up to 1g/kg body weight.
Glutaric acid has been shown to have anti-infectious properties by inhibiting the growth of bacteria, fungi, and viruses.
The effectiveness of glutaric acid against infectious diseases appears to depend on Glutaric acid ability to block protein synthesis by inhibiting enzymes such as glutathione reductase

Glutaric acid is the organic compound with the formula C3H6(COOH).
Although the related "linear" dicarboxylic acids adipic and succinic acids are water-soluble only to a few percent at room temperature, the water-solubility of glutaric acid is over 50% (w/w).

Physical Description of Glutaric acid:
Glutaric acid appears as colorless crystals or white solid.

Applications of Glutaric acid:
Glutaric acid may be employed as starting reagent in the synthesis of glutaric anhydride.
Glutaric acid may be used for the following studies:

Complexation with DL-lysine.
Complexes have been reported to possess zwitterionic lysinium ions (positively charged) and semi-glutarate ions (negatively charged).

Synthesis of complexes with L-arginine and L-histidine.
Preparation of glycine-glutaric acid co-crystals.
Phase transition studies of these cocrystals have been reported by single-crystal X-ray diffraction, polarized Raman spectroscopy and differential scanning calorimetry.

Glutaric acid is used as the raw material for organic synthesis, pharmaceutical intermediate and synthetic resin.
Glutaric acid serves as a precursor in the production of polyester polyols, polyamides, ester plasticizers and corrosion inhibitors.

Glutaric acid is useful to decrease polymer elasticity and in the synthesis surfactants and metal finishing compounds.
Glutaric acid acts as an intermediate during the catabolism of lysine in mammals.

Uses of Glutaric acid:
We prepare 1, 5-Pentanediol that is a common plasticizer and a precursor to polyesters by hydrogenation of glutamic acid and Glutaric acid derivatives.
In addition, we use glutaric acid itself in the production of polymers such as polyamides, and polyols.

Also, the odd number of the carbon atom that is 5 is very useful in decreasing the polymer elasticity.
Moreover, we get uvitonic acid by the action of ammonia on glutaric acid.

Hydrogenation of glutaric acid and Glutaric acid derivatives produces a placticizers.
Used to produce many polymers such as polyesters, polyamides.

1,5-Pentanediol, a common plasticizer and precursor to polyesters is manufactured by hydrogenation of glutaric acid and Glutaric acid derivatives.
Glutaric acid itself has been used in the production of polymers such as polyester polyols, polyamides.

The odd number of carbon atoms (i.e. 5) is useful in decreasing polymer elasticity.
Uvitonic acid is obtained by the action of ammonia on glutaric acid.
Pyrogallol can be produced from glutaric diester.

Industry Uses:
Adsorbents and absorbents
Corrosion inhibitors and anti-scaling agents
Intermediates
Plasticizers
Processing aids, not otherwise listed

Consumer Uses:
Adhesives and sealants
Water treatment products

Other Uses:
Buffering
Flavouring
Processing aid not otherwise specified
Processing aids and additives

Glutaric Acid Formula and Structure:
The chemical formula of glutaric acid is C3H6(COOH)2.
Glutaric acid is an alpha, omega-dicarboxylic acid that has linear five-carbon dicarboxylic acid.

In addition, Glutaric acid plays a role as a human metabolite and Daphnia Magna metabolite.
Furthermore, Glutaric acid is the conjugate acid of glutarate(1- ) and glutamate.
Glutaric acid molecular weight is 132.12 g/mol.

Biochemistry of Glutaric acid:
Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan.
Defects in this metabolic pathway can lead to a disorder called glutaric aciduria, where toxic byproducts build up and can cause severe encephalopathy.

Naturally, the body produces glutaric acid during the metabolism of some amino acids that include tryptophan and lysine.
In addition, defects in this metabolic pathway can lead to a disorder called glutaric aciduria, where toxic byproducts build up and can cause severe encephalopathy.

Pharmacology and Biochemistry of Glutaric acid:

Human Metabolite Information:

Tissue Locations:
Placenta
Prostate

Cellular Locations:
Cytoplasm

Properties of Glutaric Acid:
Glutaric acid appears as a colorless crystal or white solid.
Also, Glutaric acid boiling point is 303oC or 200oC at 20 mmHg.

On the other hand, Glutaric acid melting point is in between 97.5to98oC.
While the relating ‘linear’ dicarboxylic acids adipic and succinic acids are soluble in water only to a few percent at room temperature.

However, glutaric acid is soluble in water and freely soluble in absolute alcohol, ether, benzene, chloroform, and sulfuric acid.
In contrast, Glutaric acid is slightly soluble in petroleum ether.
Glutaric acid has a density of 1.4 g/cm3.

Production of Glutaric acid:
Glutaric acid can be prepared by the ring-opening of butyrolactone with potassium cyanide to give the mixed potassium carboxylate-nitrile that is hydrolyzed to the diacid.
Alternatively hydrolysis, followed by oxidation of dihydropyran gives glutaric acid.
Glutaric acid can also be prepared from reacting 1,3-dibromopropane with sodium or potassium cyanide to obtain the dinitrile, followed by hydrolysis.

We can produce glutaric acid by the ring-opening of butyrolactone with potassium cyanide to provide the mixed potassium carboxylate-nitrile that is hydrolyzed to the diacid.

An alternative method is a hydrolysis that is followed by oxidation of dihydropyran that gives glutaric acid.
We can also prepare by reacting 1, 3-dibromopropane with sodium or potassium cyanide to acquire the dinitrile followed by hydrolysis.

Manufacturing Methods of Glutaric acid:
Manufactured from cyclopentanone by oxidative ring fission with hot 50% nitric acid in the presence of vanadium cyanide.
Lab prepn by acid hydrolysis of trimethylene cyanide or of methylenedimalonic ester.

Oxidation of cyclopentanone with 50% nitric acid in the presence of vanadium pentoxide or with air in the presence of a catalyst; by-product in the production of adipic acid from cyclohexane by oxidation with air & nitric acid

General Manufacturing Information of Glutaric acid:

Industry Processing Sectors:
All other basic organic chemical manufacturing
Plastic material and resin manufacturing
Utilities

15,000 cu m/hr offgas containing 10-15% sulfur dioxide & 0.5-2 mg h2s/cu m is scrubbed in 4 successive packed columns @ 35 °c with 40-55 cu m/hr 30% aq glutaric acid.
A composition for neutralizing or destroying a susceptible virus on infected tissue of a living mammal contains an effective concn of glutaric acid in pharmaceutical vehicle as well as paper or cloth coated or impregnated with the virucide.
Glutaric acid may be an essential precursor in the biosynthesis of biotin by a species of agrobacterium.

Solubility of Glutaric acid:
Soluble in water, alcohol, benzene and chloroform.
Slightly soluble in petroleum ether.

Reactivity Profile of Glutaric acid:
Glutarıc Acıd is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.

They react in this way with all bases, both organic (for example, the amines) and inorganic.
Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.

Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0.

Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.
Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.

Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Glutaric acid to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.

Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.
Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.

Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.
Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.

Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.

A wide variety of products is possible.
Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions This compound reacts with bases, oxidizing agents and reducing agents.

Safety of Glutaric acid:
Glutaric acid may cause irritation to the skin and eyes.
Acute hazards include the fact that this compound may be harmful by ingestion, inhalation or skin absorption.

First Aid of Glutaric acid:

EYES:
First check the victim for contact lenses and remove if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.

Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN:
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital.

Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.

Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.

DO NOT INDUCE VOMITING.
IMMEDIATELY transport the victim to a hospital.

Fire Fighting of Glutaric acid:
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
A water spray may also be used.

Spillage Disposal of Glutaric acid:
Sweep spilled substance into covered containers.
If appropriate, moisten first to prevent dusting.
Then wash away with plenty of water.

Handling and Storage of Glutaric acid:

Nonfire Spill Response:

SMALL SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container.
Use absorbent paper dampened with water to pick up any remaining material.

Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Wash all contaminated surfaces with a soap and water solution.
Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS:
You should store this chemical at ambient temperatures, and keep Glutaric acid away from oxidizing materials.

Safe Storage of Glutaric acid:
Separated from bases.

Glutaric Acid Health and Safety Hazards:
Glutaric acid can cause irritation to the eyes, respiratory tract, and skin.
The compound has an acute/chronic effects like Glutaric acid is harmful by inhalation, ingestion, or skin absorption.

Also, when heated to decomposition Glutaric acid may emit acrid smoke, toxic fumes of carbon dioxide, and carbon monoxide, and irritating fumes.
If someone inhales Glutaric acid then Glutaric acid can also cause sore throat and cough also Glutaric acid touches the skin or eyes then Glutaric acid causes redness and pain in the area.
Glutaric acid ingestion can cause abdominal pain.

Identifiers of Glutaric acid:
CAS Number: 110-94-1
ChEBI: CHEBI:17859
ChEMBL: ChEMBL1162495
ChemSpider: 723
DrugBank: DB03553
ECHA InfoCard: 100.003.471
EC Number: 203-817-2
KEGG: C00489
PubChem CID: 743
UNII: H849F7N00B
CompTox Dashboard (EPA): DTXSID2021654
InChI:
InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9) check
Key: JFCQEDHGNNZCLN-UHFFFAOYSA-N check
InChI=1/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)
Key: JFCQEDHGNNZCLN-UHFFFAOYAU
SMILES: C(CC(=O)O)CC(=O)O

Properties of Glutaric acid:
Chemical formula: C5H8O4
Molar mass: 132.12 g/mol
Melting point: 95 to 98 °C (203 to 208 °F; 368 to 371 K)
Boiling point: 200 °C (392 °F; 473 K) /20 mmHg

Molecular Weight: 132.11
XLogP3: -0.3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 4
Exact Mass: 132.04225873
Monoisotopic Mass: 132.04225873
Topological Polar Surface Area: 74.6 Ų
Heavy Atom Count: 9
Complexity: 104
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Physicochemical Information of Glutaric acid:
Boiling point: 302 - 304 °C (1013 hPa) (slow decomposition)
Density: 1.429 g/cm3 (15 °C)
Melting Point: 97.5 - 98 °C
Vapor pressure: 0.022 hPa (18.5 °C)
Solubility: 640 g/l

Specifications of Glutaric acid:
Assay (acidimetric): ≥ 99,0 %(m)
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 99 °C
Identity (IR): conforms

Names of Glutaric acid:

Preferred IUPAC name:
Pentanedioic acid

Other names:
Glutaric acid
Propane-1,3-dicarboxylic acid
1,3-Propanedicarboxylic acid
Pentanedioic acid
n-Pyrotartaric acid
GLYCERETH-17 COCOATE
GLYCERETH-17 COCOATE GLYCERETH-17 COCOATE GLYCERETH-17 COCOATE is classified as : Emulsifying Surfactant COSING REF No: 76272 Chem/IUPAC Name: Poly(oxy-1,2-ethanediyl),.alpha.,.alpha'.,.alpha''.-1,2,3-propanetriyltris[.omega.-hydroxy- (17 mol EO average molar ratio), ester with fatty acids derived from coconut oil GLYCERETH-17 COCOATE is an extra-mild non-ionic surfactant with co-emulsifying and solubilizing properties. Ecological product. It doesn’t need any risk or safety warnings on its label. What Is Glycereth-17 Cocoate? Glycereth-17 cocoate is a slightly soluble liquid or solid that is derived from coconut oil.[1,2] What Does Glycereth-17 Cocoate Do in Our products? Glycereth-17 cocoate is an emulsifier and a surfactant.[3,4] It is often found in foaming hand sanitizers.[5] Why Puracy Uses Glycereth-17 Cocoate We use glycereth-17 cocoate as a cleanser and to keep ingredients from separating. Whole Foods has deemed the ingredient acceptable in its body care and cleaning product quality standards.[7,8] How Glycereth-17 Cocoate Is Made Glycereth-17 cocoate is an ester of coconut acid and a polyethylene glycol either of glycerin. Glycereth-17 Cocoate Laundry & Cleaning (Home Care), Laundry & Cleaning (Industrial & Institutional Cleaning) Non-Ionic surfactant with emulsifying properties for concentrated formulations. Glycereth-17 Cocoate Personal Care (Hair Care), Personal Care (Skin Care) Mild solubilizer. Category Non-ionic surfactant > Polyether >> Ester Polyether >>> Ester Polyoxyethylene Ether >>>> Polyoxyethylene Glyceryl Esters Properties Appearance (1), liquid to solid. Solubility slightly soluble in water to soluble in water. The solubility increases with the increase of EO number. Stability stable. Easily oxidized. Under strong acid or strong alkali condition, easily hydrolyzed. Risk Solid (or liquid) form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn. GHS (Rev.8) label: Ecology may be hazardous to environment. Water body should be given special attention. Biodegradability biodegradable. Characteristics excellent emulsifying, dispersing, solubilizing, lubricating abilities. Performance is related to EO number. Note (1), The by-product 1,4-dioxane is a possible carcinogen. Generally, can be acceptable when concentration of 1,4-dioxane is less than 30ppm or less. (2), Be careful with using in children's products. Further explanation (a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight. (b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards. Major Uses 1, Typical applications Use as emulsifying agent, dispersing agent. Use as solubilizing agent. Use as plasticizer. Use as lubricant. 2, Personal care products Conditioning agent, emulsifying agent, humectant in personal care products. Product members Glycereth-2 Cocoate; Glycereth-5 Cocoate; Glycereth-7 Cocoate; Glycereth-17 Cocoate; Glycereth-20 Cocoate INCI name GLYCERETH-17 COCOATE Alternative names No information available Origin Chemical Definition Poly(oxy-1,2-ethanediyl),.alpha.,.alpha'.,.alpha".-1,2,3-propanetriyltris[.omega.-hydroxy(17 mol EO average molar ratio), ester with fatty acids derived from coconut oil INCI function Surfactant, Emulsifying The INCI function describes solely the purpose of a cosmetic ingredient. It does not reveal its actual effects and skin compatibility. You'll find these and other characteristics below. Applications Products application: hard surface cleaners, laundry products, HDLD, HDPD,···. Properties Non-ionic mild surfactant. Ecological and toxicological advantages against typical non-ionic (ethoxylated fatty alcohols). Natural source - Vegetable origin.
GLYCERIN TRIPALMITATE

Glycerin tripalmitate is a white, solid compound with a waxy texture.
Glycerin tripalmitate has a characteristic odor and is odorless.

CAS number: 555-44-2
EC number: 209-008-0



APPLICATIONS


Glycerin tripalmitate is commonly used as a texturizer and stabilizer in the production of margarine and spreads.
Glycerin tripalmitate enhances the smoothness, spreadability, and mouthfeel of food products.
Glycerin tripalmitate acts as an emulsifier in bakery products, helping to blend fat and water-based ingredients.

Glycerin tripalmitate is utilized in the formulation of confectionery, providing a creamy texture and improving shelf stability.
Glycerin tripalmitate serves as a moisturizing and emollient agent in skincare products such as creams, lotions, and balms.
Glycerin tripalmitate helps prevent moisture loss from the skin, keeping it hydrated and supple.

Glycerin tripalmitate finds application in lipsticks, providing a smooth application and long-lasting wear.
Glycerin tripalmitate is used as a binder in pharmaceutical tablet formulations, ensuring the integrity and strength of the tablets.
Glycerin tripalmitate is employed in solid dosage forms such as capsules, providing controlled release of active ingredients.

Glycerin tripalmitate acts as a lubricant in industrial applications, reducing friction and improving machinery performance.
Glycerin tripalmitate is utilized in metalworking processes to enhance machining operations and reduce wear on cutting tools.

Glycerin tripalmitate finds application as a mold release agent in manufacturing processes, preventing sticking or adhesion.
Glycerin tripalmitate is used in the formulation of printing inks, providing smoothness and gloss to the printed surface.

Glycerin tripalmitate acts as a carrier or matrix material in encapsulation processes, protecting and controlling the release of active ingredients.
Glycerin tripalmitate is employed in the production of candles, improving burn time, texture, and fragrance retention.
Glycerin tripalmitate serves as a coating ingredient in paint formulations, enhancing adhesion and durability.

Glycerin tripalmitate finds application as a release agent in the production of rubber and plastic products, facilitating demolding.
Glycerin tripalmitate is used in the formulation of polishes and waxes for surfaces such as wood and leather, providing shine and protection.
Glycerin tripalmitate serves as a lubricant and processing aid in the plastic industry, aiding in molding and extrusion processes.

Glycerin tripalmitate acts as an adhesive component in industrial adhesives, providing tackiness and bonding properties.
Glycerin tripalmitate is used in animal feed formulations, serving as a concentrated energy source for livestock.

Glycerin tripalmitate finds application in the research and development of lipid-based drug delivery systems.
Glycerin tripalmitate is utilized in the study of emulsion science and formulation of stable emulsions for various applications.

Glycerin tripalmitate serves as a calibration standard in analytical techniques such as chromatography and spectroscopy.
Glycerin tripalmitate has versatile applications in food, cosmetics, pharmaceuticals, industrial processes, and research, making it a valuable compound in multiple industries.
Glycerin tripalmitate is used as a plasticizer in the plastic industry, improving flexibility and reducing brittleness in plastic materials.

Glycerin tripalmitate finds application in the formulation of adhesives for woodworking and construction purposes.
Glycerin tripalmitate is utilized in the production of wax-based coatings for surfaces such as paper, cardboard, and textiles.

Glycerin tripalmitate serves as a conditioning agent in hair care products, providing softness and manageability to the hair.
Glycerin tripalmitate is used in the formulation of lip balms, providing hydration and protection to the lips.

Glycerin tripalmitate finds application in the production of ointments and creams for pharmaceutical and dermatological use.
Glycerin tripalmitate is utilized in the formulation of sunscreen products, enhancing the dispersion of UV filters and improving their efficacy.
Glycerin tripalmitate is employed in the production of pressed powders in the cosmetic industry, providing binding and smoothing properties.

Glycerin tripalmitate serves as a lubricant in the processing of polymers, facilitating extrusion and injection molding.
Glycerin tripalmitate finds application in the production of resin-based art materials, providing texture and workability.
Glycerin tripalmitate is used as a film-forming agent in the coating of tablets to improve swallowability and mask unpleasant tastes.

Glycerin tripalmitate finds application in the production of solid perfumes, providing a long-lasting fragrance release.
Glycerin tripalmitate is utilized in the formulation of stick foundations, providing a creamy texture and smooth application.
Glycerin tripalmitate acts as a suspending agent in oral suspensions, helping to disperse insoluble particles uniformly.
Glycerin tripalmitate finds application in the production of suppositories, enhancing their stability and ease of insertion.

Glycerin tripalmitate serves as a lubricant and release agent in the production of rubber goods and molded parts.
Glycerin tripalmitate is used in the formulation of personal lubricants, providing smoothness and reducing friction during intimate activities.
Glycerin tripalmitate finds application in the production of specialty soaps, contributing to their texture and cleansing properties.
Glycerin tripalmitate is utilized in the formulation of wax-based crayons, improving color transfer and durability.

Glycerin tripalmitate acts as a spreading agent in agricultural applications, aiding the uniform distribution of pesticides and fertilizers.
Glycerin tripalmitate finds application in the production of biodegradable plastics, contributing to their mechanical and thermal properties.

Glycerin tripalmitate is used in the formulation of pharmaceutical creams and gels for topical drug delivery.
Glycerin tripalmitate finds application in the production of flavor and fragrance encapsulation systems, improving stability and release characteristics.
Glycerin tripalmitate serves as a carrier for fat-soluble vitamins and nutraceuticals in food and dietary supplements.
Glycerin tripalmitate is utilized in the production of specialty inks, such as those used for gravure printing and flexography.


Glycerin tripalmitate (tripalmitin) has several applications across different industries.
Some of its main applications include:

Food Industry:
Glycerin tripalmitate is used as a food additive and ingredient.
Glycerin tripalmitate serves as a texturizer, stabilizer, and emulsifier in various food products, such as margarine, spreads, baked goods, confectionery, and processed meats.

Cosmetics and Personal Care:
Glycerin tripalmitate is widely used in cosmetics and personal care products.
Glycerin tripalmitate is employed as a thickening agent, emollient, and moisturizer in creams, lotions, balms, lipsticks, and other skincare formulations.

Pharmaceuticals:
Glycerin tripalmitate finds application in the pharmaceutical industry.
Glycerin tripalmitate is utilized as a binder in tablet formulations, helping to hold the active ingredients together and provide cohesive tablets.

Industrial Lubricants:
Glycerin tripalmitate has lubricating properties, making it suitable for use in industrial lubricants, greases, and cutting fluids.
Glycerin tripalmitate helps reduce friction and enhance the performance of machinery and equipment.

Research and Development:
Glycerin tripalmitate is utilized in research and development activities as a standard reference material.
Glycerin tripalmitate serves as a calibration standard for analytical techniques, such as chromatography and spectroscopy.

Encapsulation:
Glycerin tripalmitate is used in encapsulation processes, where it acts as a carrier or matrix material for encapsulating active ingredients, flavors, or fragrances.
Glycerin tripalmitate helps protect the encapsulated substances and control their release.

Coatings and Inks:
Glycerin tripalmitate can be found in coatings and inks, particularly in the formulation of wax-based coatings and printing inks.
Glycerin tripalmitate imparts gloss, smoothness, and moisture resistance to the coatings and inks.

Industrial Applications:
Glycerin tripalmitate is employed in various industrial applications, including metalworking, lubricant additives, plasticizers, and mold release agents.

Candle Making:
Glycerin tripalmitate is utilized in candle making as a component of wax formulations.
Glycerin tripalmitate helps improve the texture, burn time, and fragrance retention of candles.

Paints and Coatings:
Glycerin tripalmitate is employed in the formulation of paints and coatings, particularly in oil-based systems.
Glycerin tripalmitate acts as a binder, providing adhesion and durability to the paint film.

Release Agent:
Glycerin tripalmitate is used as a release agent in various manufacturing processes.
Glycerin tripalmitate helps prevent sticking or adhesion of materials to molds, surfaces, or equipment during production.

Polishing and Finishing Products:
Glycerin tripalmitate is found in polishes, waxes, and finishing products for surfaces such as wood, leather, and furniture.
Glycerin tripalmitate enhances the shine, protection, and smoothness of these surfaces.

Industrial Adhesives:
Glycerin tripalmitate is utilized in the formulation of industrial adhesives, providing tackiness and adhesive properties to the products.

Plastic Industry:
Glycerin tripalmitate finds application in the plastic industry as a lubricant, processing aid, and anti-blocking agent during plastic molding and extrusion processes.

Animal Nutrition:
Glycerin tripalmitate is used in animal feed formulations.
Glycerin tripalmitate provides a concentrated source of energy and helps improve the texture and palatability of feed pellets.

Research and Development:
Glycerin tripalmitate is used in various research and development applications, including lipid studies, emulsion science, and drug delivery systems.

Surfactant Systems:
Glycerin tripalmitate can be employed as an ingredient in surfactant systems, where it helps stabilize emulsions and improve the texture of personal care and household cleaning products.

Seed Coating:
Glycerin tripalmitate is utilized in seed coating formulations to improve the flowability, dispersibility, and adherence of active ingredients onto seeds.



DESCRIPTION


Glycerin tripalmitate is a white, solid compound with a waxy texture.
Glycerin tripalmitate has a characteristic odor and is odorless.

Glycerin tripalmitate has a high melting point, typically around 63-65 degrees Celsius.
Glycerin tripalmitate is insoluble in water.
Glycerin tripalmitate is soluble in organic solvents such as ethanol, chloroform, and ether.

Glycerin tripalmitate appears as small crystals or flakes.
Glycerin tripalmitate is derived from the esterification of glycerol with three molecules of palmitic acid.
Glycerin tripalmitate is a triglyceride, belonging to the class of neutral lipids.
Glycerin tripalmitate formula of glycerin tripalmitate is C₅₃H₁₀₀O₆.

Glycerin tripalmitate is commonly found in natural fats and oils, particularly palm oil and animal fats.
Glycerin tripalmitate serves as an energy source in living organisms.
Glycerin tripalmitate is used in various industrial applications, including food, cosmetics, and pharmaceuticals.

Glycerin tripalmitate acts as an emulsifier, helping to blend oil and water-based ingredients.
Glycerin tripalmitate serves as a stabilizer, enhancing the consistency and shelf life of products.

Glycerin tripalmitate functions as a thickening agent, providing viscosity and texture to formulations.
Glycerin tripalmitate is utilized in the production of margarine, spreads, and baked goods, improving their texture and stability.
Glycerin tripalmitate is commonly found in skincare products, providing moisturizing and smoothing properties.
Glycerin tripalmitate contributes to the creamy texture and emollient effects of lotions, creams, and lip balms.

Glycerin tripalmitate is used in the formulation of solid dosage forms in the pharmaceutical industry.
Glycerin tripalmitate acts as a binder, helping to hold tablets together and maintain their integrity.

Glycerin tripalmitate, also known as glycerol tripalmitate or tripalmitin, is a chemical compound classified as a triglyceride.
Glycerin tripalmitate is an ester formed from the esterification of glycerol (glycerin) with three molecules of palmitic acid.
The chemical formula of glycerin tripalmitate is C₅₃H₁₀₀O₆.

Glycerin tripalmitate is a solid substance with a white or off-white color, and it has a melting point of approximately 63-65 degrees Celsius.
Glycerin tripalmitate is primarily found in natural fats and oils, such as palm oil and animal fats.
Glycerin tripalmitate is widely used in various industries, including food, cosmetics, pharmaceuticals, and research, due to its functional properties as an emulsifier, stabilizer, and thickening agent.



PROPERTIES


Chemical Formula: C₅₃H₁₀₀O₆
Molecular Weight: 853.43 g/mol
Physical State: Solid
Appearance: White or off-white solid
Odor: Odorless
Melting Point: Approximately 63-65 degrees Celsius
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water
Solubility in Organic Solvents: Soluble in organic solvents such as ethanol, chloroform, and ether
Density: 0.942 g/cm³
Refractive Index: 1.433-1.437
Viscosity: 6.17 mPa·s at 20 degrees Celsius
Flash Point: >200 degrees Celsius (closed cup)
Autoignition Temperature: Approximately 400 degrees Celsius
pH Value: Not applicable (pH neutral)
Stability: Stable under normal conditions
Flammability: Not flammable
Explosion Limits: Not applicable (non-explosive)



FIRST AID


Inhalation:

If inhalation of the compound occurs, remove the affected person to fresh air immediately.
If respiratory symptoms develop, seek medical attention.
Provide artificial respiration if the person is not breathing, and administer oxygen if available.


Skin Contact:

In case of skin contact, promptly remove contaminated clothing and shoes.
Wash the affected area thoroughly with soap and water for at least 15 minutes.
Seek medical advice if irritation or any adverse effects persist.


Eye Contact:

If the compound comes into contact with the eyes, rinse them gently with lukewarm water for at least 15 minutes, ensuring to remove any contact lenses if present and easy to do so.
Seek immediate medical attention and continue rinsing the eyes during transport to the medical facility.


Ingestion:

If glycerin tripalmitate is ingested accidentally, do not induce vomiting unless instructed to do so by medical personnel.
Rinse the mouth with water and give the affected person a small amount of water to drink if they are conscious and able to swallow.
Seek immediate medical attention and provide the medical staff with as much information as possible.



HANDLING AND STORAGE


Handling:

Personal Protection:
When handling glycerin tripalmitate, it is advisable to wear appropriate personal protective equipment (PPE) to minimize the risk of exposure.
This may include gloves, safety goggles or glasses, and protective clothing.

Ventilation:
Ensure that the handling area is well-ventilated to prevent the accumulation of vapors or dust.
Use local exhaust ventilation or mechanical ventilation if necessary.

Avoid Direct Contact:
Avoid direct contact with the compound.
If handling in powder form, minimize the generation of dust by using appropriate handling techniques, such as closed systems or dust collection equipment.

Good Hygiene Practices:
Practice good hygiene measures, such as washing hands thoroughly with soap and water after handling.
Avoid touching the face, eyes, or mouth with contaminated hands.

Avoid Incompatible Materials:
Keep glycerin tripalmitate away from strong oxidizing agents, strong acids, and alkalis, as they may react with or degrade the compound.

Static Electricity:
Take precautions to prevent the buildup of static electricity, as it may result in ignition or fire hazards.
Use grounding techniques and avoid frictional activities.


Storage:

Store in a Cool, Dry Place:
Store glycerin tripalmitate in a cool, dry place away from direct sunlight and sources of heat.
Maintain storage temperatures below 40 degrees Celsius.

Fire Protection:
Keep the compound away from potential ignition sources, such as open flames, sparks, and heat-generating equipment.
Follow appropriate fire protection measures in the storage area.

Chemical Compatibility:
Store glycerin tripalmitate separately from incompatible materials, such as strong oxidizing agents, strong acids, and alkalis, to prevent reactions or degradation.

Container Selection:
Store the compound in tightly sealed containers made of suitable materials, such as high-density polyethylene (HDPE) or stainless steel, to prevent leakage or contamination.

Labeling:
Ensure proper labeling of containers with the correct product name, hazards, and handling instructions.
This helps prevent confusion and ensures safe storage and handling.

Accessibility:
Store glycerin tripalmitate in a location that is only accessible to authorized personnel who are trained in its handling and aware of the associated hazards.

Spill and Leak Response:
Develop and implement procedures for spill and leak response, including containment measures and appropriate clean-up methods.
Dispose of waste material in accordance with local regulations.

Inventory Control:
Maintain proper inventory control to monitor storage conditions, expiration dates, and quantities of glycerin tripalmitate to minimize the risk of degradation or stock depletion.



SYNONYMS


Tripalmitin
Glyceryl Tripalmitate
Triglyceride Palmitin
Palmitic Acid Triglyceride
Glycerol Tripalmitate
Glycerol Palmitate
Glyceryl Palmitate Triester
Triglycerol Palmitate
Palmitoyl Glycerol
1,2,3-Tri-palmitoyl-glycerol
Glyceryl Tris(palmitate)
Triglyceride of Palmitic Acid
Palmitoyl Glycerin
1,2,3-Tri-palmitin
Glycerol Palmitate Triester
Glycerin Palmitate Triester
Tris(palmitoyl) Glycerol
Triglyceride C16
Tripalmitin Glyceride
Glycerin Palmitin
Glycerol Ester of Palmitic Acid
Palmitin
Palmitin Triglyceride
Glycerol Palmitic Acid Ester
Triglycerol Ester of Palmitic Acid
Palmitic Triglyceride
Tri-palmitoyl Glycerol
Palmitic Acid Glycerol Ester
Glyceryl Tripalmitate Palmitate
Glycerol Trihexadecanoate
Triglycerol Palmitate Ester
Glycerol Triester of Palmitic Acid
Glycerol Triglyceride Palmitate
Palmitoyl Glycerol Triester
Glycerol Tripalmitin
Tripalmitoyl Glycerol
Glyceryl Tri-palmitate
Triglycerol Palmitic Acid Ester
Glycerol Palmitic Acid Triester
Palmitoyl Glycerol Tri-palmitate
Glycerol Ester of Hexadecanoic Acid
Tri-palmitin Glyceride
Glycerol Esters of Palmitic Acid
Triglyceride Palmitate Ester
Glycerol 1,2,3-Tripalmitate
Palmitic Triglycerol
Tripalmitin Glyceride
Glycerol Tripalmitoyl Ester
Palmitic Acid Glycerol Triester
Glycerol Palmitic Triester
Tris(palmitoyl) Glycerol Ester
Glyceryl Palmitate Triglyceride
Triglyceride of Hexadecanoic Acid
Glycerol Tripalmitoylglycerol
Glycerin Tri-palmitoyl Ester
Palmitoyl Glycerol Palmitate
Triglyceride Palmitic Acid Triester
Glycerol Hexadecanoate Ester
Glycerol 1,2,3-Trihexadecanoate
Trihexadecanoyl Glycerol
GLYCERINE MONOOLEATE
Glycerine; Glycerol; 1,2,3-Propanetriol; Glyceritol; Glycic Alcohol; 1,2,3-Trihydroxypropane; Trihydroxypropane; Clyzerin, Wasserfrei; Glyrol; Glysanin; Grocolene cas no: 56-81-5
GLYCERINE MONOSTEARATE
Glycerine Monostearate Glycerine monostearate is composed of primary and auxiliary emulsifiers for a wide variety of personal care formulas. It is supplied as cream flakes. Glycerine monostearate is an emulsifier for a wide variety of personal care applications. Product: Cerasynt Stearates Industries: Personal Care Form: White to off-white flakes Use level: 0.25 - 3.0% Features & Benefits Nonionic auxiliary emulsifier Emulsion stabilizer Biodegradable 100% Natural Vegan suitable Impurities and other Glycerine monostearate risks According to a report in the International Journal of Toxicology by the cosmetic industry’s own Cosmetic Ingredient Review (CIR) committee, impurities found in various PEG compounds include ethylene oxide; 1,4-dioxane; polycyclic aromatic compounds; and heavy metals such as lead, iron, cobalt, nickel, cadmium, and arsenic. Many of these impurities are linked to cancer. PEG compounds often contain small amounts of ethylene oxide. Ethylene oxide (found in PEG-4, PEG-7, PEG4-dilaurate, and PEG 100) is highly toxic — even in small doses — and was used in World War I nerve gas. Exposure to ethylene glycol during its production, processing and clinical use has been linked to increased incidents of leukemia as well as several types of cancer. Finally, there is 1,4-dioxane (found in PEG-6, PEG-8, PEG-32, PEG-75, PEG-150, PEG-14M, and PEG-20M), which, on top of being a known carcinogen, may also combine with atmospheric oxygen to form explosive peroxides — not exactly something you want going on your skin. Even though responsible manufacturers do make efforts to remove these impurities (1,4-dioxane that can be removed from cosmetics through vacuum stripping during processing without an unreasonable increase in raw material cost), the cosmetic and personal care product industry has shown little interest in doing so. Surprisingly, PEG compounds are also used by natural cosmetics companies. Properties Chemical formula C21H42O4 Molar mass 358.563 g·mol−1 Appearance White solid Density 1.03 g/cm3 Melting point (Mix) 57–65 °C (135–149 °F) (1-) 81 °C (178 °F) [1] (2-) 73–74 °C (163–165 °F) Solubility in water Insoluble If you find Glycerine monostearate in your cosmetics… Although you might find conflicting information online regarding Polyethylene Glycol, PEGs family and their chemical relatives, it is something to pay attention to when choosing cosmetic and personal care products. If you have sensitive or damaged skin it might be a good idea to avoid products containing PEGs. Using CosmEthics app you can easy add PEGs to personal alerts. In our last blog post we wrote about vegan ingredients. Natural glycols are a good alternative to PEGs, for example natural vegetable glycerin can be used as both moisturiser and emulsifier. CosmEthics vegan list can help you find products that use vegetable glycerin as wetting agent. At present, there is not enough information shown on product labels to enable you to determine whether PEG compounds are contaminated. But if you must buy a product containing PEGs just make sure that your PEGs are coming from a respected brand. Glyceryl stearate and Glycerine monostearate is a combination of two emulsifying ingredients. The stabilising effect of both means that the product remains blended and will not separate. Description Glyceryl stearate is a solid and waxy compound. It is made by reacting glycerine (a soap by-product) with stearic acid (a naturally occurring, vegetable fatty acid). Glycerine monostearate is an off-white, solid ester of polyethylene glycol (a binder and a softener) and stearic acid. Applications Ideal for styling creams/lotions, conditioners, body care, facial care, sun care Related Applications Personal Care Cosmetics Hair Care Skin Care Sun Care Related Benefits Personal Care Natural Vegan Suitable Related Functions Personal Care Emulsifiers Glyceryl Stearate. Glycerine monostearate ester acts as an emulsion stabilizer and non-ionic auxiliary emulsifier. Glycerine monostearate ester is suggested for use in creams and lotions, conditioners and styling creams/lotions, body care, face and body washes, facial care, after-sun, self-tanning, and sunscreen applications. The Cerasynt esters range provides a variety of emulsifiers to meet formulation requirements. PROPERTIES Auxiliary emulsifiers. APPLICATIONS A wide variety of personal care formulas. Glycerine monostearate is a premium quality nonionic stabilizer and emulsifier. Manufactured using the highest quality raw materials for batch-to-batch reproducibility. What Is Glycerine monostearate? Glycerine monostearate and Glycerine monostearate SE are esterification products of glycerin and stearic acid. Glycerine monostearate is a white or cream-colored wax-like solid. Glycerine monostearate is a "Self-Emulsifying" form of Glycerine monostearate that also contains a small amount of sodium and or potassium stearate. In cosmetics and personal care products, Glycerine monostearate is widely used and can be found in lotions, creams, powders, skin cleansing products, makeup bases and foundations, mascara, eye shadow, eyeliner, hair conditioners and rinses, and suntan and sunscreen products. Why is Glycerine monostearate used in cosmetics and personal care products? Glycerine monostearate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. It also slows the loss of water from the skin by forming a barrier on the skin's surface. Glycerine monostearate, and Glycerine monostearate SE help to form emulsions by reducing the surface tension of the substances to be emulsified. Scientific Facts: Glycerine monostearate is made by reacting glycerin with stearic acid, a fatty acid obtained from animal and vegetable fats and oils. Glycerine monostearate SE is produced by reacting an excess of stearic acid with glycerin. The excess stearic acid is then reacted with potassium and/or sodium hydroxide yielding a product that contains Glycerine monostearate as well as potassium stearate and/or sodium stearate. What Is Glycerine monostearate Glycerine monostearate is esterification products of glycerin and stearic acid. Glycerine monostearate is a white or cream-colored wax-like solid. Glycerine monostearate SE is a "Self-Emulsifying" form of Glycerine monostearate that also contains a small amount of sodium and or potassium stearate. In cosmetics and personal care products, Glycerine monostearate is widely used and can be found in lotions, creams, powders, skin cleansing products, makeup bases and foundations, mascara, eye shadow, eyeliner, hair conditioners and rinses, and suntan and sunscreen products. Why is it used in cosmetics and personal care products? Glycerine monostearate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. It also slows the loss of water from the skin by forming a barrier on the skin's surface. Glycerine monostearate, and Glycerine monostearate SE help to form emulsions by reducing the surface tension of the substances to be emulsified. Glycerine monostearate is derived from palm kernel, vegetable or soy oil and is also found naturally in the human body. It acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. It easily penetrates the skin and slows the loss of water from the skin by forming a barrier on the skin's surface. It has been shown to protect skin from free-radical damage as well. Functions of Glycerine monostearate Glycerine monostearate is derived from palm kernel, vegetable or soy oil and is also found naturally in the human body. It acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance (Source). It easily penetrates the skin and slows the loss of water from the skin by forming a barrier on the skin's surface. It has been shown to protect skin from free-radical damage as well. Chemically, Glycerine monostearate is used to stabilize products, decrease water evaporation, make products freeze-resistant, and keep them from forming surface crusts. Description: Glycerine monostearate SE (self-emulsifying as it contains a small amount 3-6% of potassium stearate) is the monoester of glycerin and stearic acid. Vegetable origin. It is an emulsifier with a HLB value of 5.8 and thus useful for making water-in-oil emulsions. It can also be used as a co-emulsifier and thickener for oil- in-water formulations. Off-white flakes, bland odor. Soluble in oil. CAS: 123-94-4 INCI Name: Glycerine monostearate Properties: Emulsifies water and oil phase, acts as stabilizer and thickener in o/w formulations, widely used in a variety of different cosmetic formulations. Use: Add to oil/emulsifier phase of formulas, melts at 55°C/130°F. Use level: 1-10%. For external use only. Applications: Moisturizing creams, lotions, ointments, antiperspirant, hair care and sunscreen. Glycerine monostearate (GMS) is one of the most commonly used ingredients in personal care formulations. But it's a material that is not well understood by most formulators. GMS (EU) is normally used as a low-HLB thickening agent in lamellar gel (EU) network (LGN)-based oil-in-water emulsions, often combined with fatty alcohols. Glycerine monostearate, also known as Glycerine monostearate, or GMS, is EcoCert certified. Glycerine monostearate is the natural glyceryl ester from stearic acid (glycerin and stearic acid) which offers skin conditioning, moisturization and hydration due to the glycerin component. Functions as a non-ionic opacifier, thickener, and formulation stabilizer, where it also imparts a softer, smoother, feel to your emulsions. Glycerine monostearate is one of the best choices, for thickening and stabilizing, to use in combination with the lactylates, where it also functions as an emollient, and gives the emulsion more smoothness. Glycerine monostearate is the end result of reaction between glycerin and stearic acid. We all know what glycerin is and does (generally vegetable based humectant), and stearic acid is a fatty acid compound extracted from a variety of vegetable, animal, and oil sources such as palm kernel and soy. The end result of the reaction with glycerin and stearic acid is a cream-colored, waxy like substance. Details A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth. Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable. NAMELY Glycerol stearate is used as a non-ionic emulsifier or emollient in cosmetic products. It is widely used in moisturizers and is also found in hair care products for its antistatic properties. It can be derived from palm, olive or rapeseed oil... It is authorized in bio. Its functions (INCI) Emollient : Softens and softens the skin Emulsifying : Promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil) This ingredient is present in 11.81% of cosmetics. Hand cream (46.51%) Moisturizing cream box (46.15%) Anti-aging night face cream (45.88%) Anti-aging hand cream (43.75%) Mascara (42.73%) Glycerine monostearate Glycerine monostearate is the natural glyceryl ester of glycerin and stearic acid. It offers excellent hydration and moisturization. It acts as a non-ionic opacifier, thickener, emollient and formulation stabilizer. It is used in skin care and body care applications. Glycerine monostearate is classified as : Emollient Emulsifying CAS Number 31566-31-1 EINECS/ELINCS No: 250-705-4 COSING REF No: 34103 INN Name: Glycerine monostearate PHARMACEUTICAL EUROPEAN NAME: glyceroli monostearas Chem/IUPAC Name: Glycerine monostearate Glycerine monostearate Learn all about Glycerine monostearate, including how it's made, and why Puracy uses Glycerine monostearate in our products. Derived from: coconut Pronunciation: (\ˈglis-rəl\ \stē-ə-ˌrāt\) Type: Naturally-derived Other names: monostearate What Is Glycerine monostearate? Glycerine monostearate, also called Glycerine monostearate, is a white or pale yellow waxy substance derived from palm kernel, olives, or coconuts. What Does Glycerine monostearate Do in Our products? Glycerine monostearate is an emollient that keeps products blended together; it can also be a surfactant, emulsifier, and thickener in food — often it’s used as a dough conditioner and to keep things from going stale.[1] In our products, however, Glycerine monostearate is used for its most common purpose — to bind moisture to the skin. For this reason, it is a common ingredient in thousands of cosmetic products, including lotions, makeup, skin cleansers, and other items. Why Puracy Uses Glycerine monostearate We use Glycerine monostearate in several of our products as a moisturizer; it also forms a barrier on the skin and prevents products from feeling greasy. As an emulsifier, it also allows products to stay blended.[5] Several studies and clinical tests find that Glycerine monostearate causes little or no skin or eye irritation and is not a danger in formulations that might be inhaled.[6,7,8] In addition, a number of clinical trials have found that Glycerine monostearate in moisturizers can lessen symptoms and signs of atopic dermatitis, including pruritus, erythema, fissuring, and lichenification.[9] In 1982 and again in 2015, the Cosmetic Ingredient Review deemed the ingredient safe for use in cosmetics.[10] Whole Foods has deemed the ingredient acceptable in its body care quality standards.[11] How Glycerine monostearate Is Made Glycerine monostearate is formed through a reaction of glycerin with stearic acid, which is a fatty acid that comes from animal and vegetable fats and oils. Glycerine monostearate SE, the self-emulsifying form of the substance, is made by reacting an excess of stearic acid with glycerin. The excess stearic acid is then reacted with potassium and/or sodium hydroxide. That produces a substance that contains Glycerine monostearate, potassium stearate, and/or sodium stearate Glycerine monostearate (GMS) is one of the most commonly used ingredients in personal care formulations. But it’s a material that is not well understood by most formulators. GMS (EU) is normally used as a low-HLB thickening agent in lamellar gel (EU) network (LGN)-based oil-in-water emulsions, often combined with fatty alcohols. LGN-based emulsions containing thickening polymers are the most common type of oil-in-water formulations sold globally. Most GMS used in personal care products should actually be called glyceryl distearate (EU), since many common grades only contain around 40% alpha monostearate (EU), 5% glyceryl tristearate (EU), and 50% glyceryl distearate. There are also grades commercially available that contain 30%, 60%, and 90% GMS. The 90% alpha mono grades can only be produced by molecular distillation and are widely used in the food industry. Functionally, there is a big difference in performance if you use a 90% versus 40% mono. A 90% mono has a higher melting point (69°C versus 58-63°C), lighter skin feel, and a higher HLB (EU) (~4-5, versus ~3). The higher HLB of the 90% mono enables you to form LGNs much easier with lower emulsifier levels and energy than when using cetyl (EU)/stearyl alcohol (EU). There are also self-emulsifying (SE) grades of GMS available, which are typically combined with PEG 100 stearate (EU), potassium stearate (EU), or sodium lauryl sulfate (EU). Glycerine monostearate, commonly known as GMS, is a monoglyceride commonly used as an emulsifier in foods.[3] It takes the form of a white, odorless, and sweet-tasting flaky powder that is hygroscopic. Chemically it is the glycerol ester of stearic acid. Structure, synthesis, and occurrence Glycerine monostearate exists as three stereoisomers, the enantiomeric pair of 1-Glycerine monostearate and 2-Glycerine monostearate. Typically these are encountered as a mixture as many of their properties are similar. Commercial material used in foods is produced industrially by a glycerolysis reaction between triglycerides (from either vegetable or animal fats) and glycerol. Glycerine monostearate occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase. It is present at very low levels in certain seed oils. Uses Glycerine monostearate is a food additive used as a thickening, emulsifying, anticaking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant. It is also used in cosmetics and hair-care products.[5] Glycerine monostearate is largely used in baking preparations to add "body" to the food. It is somewhat responsible for giving ice cream and whipped cream their smooth texture. It is sometimes used as an antistaling agent in bread. What Is It? Glycerine monostearate and Glyceryl Stearate SE are esterification products of glycerin and stearic acid. Glycerine monostearate is a white or cream-colored wax-like solid. Glycerine monostearate SE is a "Self-Emulsifying" form of Glycerine monostearate that also contains a small amount of sodium and or potassium stearate. In cosmetics and personal care products, Glycerine monostearate is widely used and can be found in lotions, creams, powders, skin cleansing products, makeup bases and foundations, mascara, eye shadow, eyeliner, hair conditioners and rinses, and suntan and sunscreen products. Why is it used in cosmetics and personal care products? Glycerine monostearate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. It also slows the loss of water from the skin by forming a barrier on the skin's surface. Glycerine monostearate, and Glycerine monostearate SE help to form emulsions by reducing the surface tension of the substances to be emulsified. Scientific Facts: Glycerine monostearate is made by reacting glycerin with stearic acid, a fatty acid obtained from animal and vegetable fats and oils. Glyceryl Stearate SE is produced by reacting an excess of stearic acid with glycerin. The excess stearic acid is then reacted with potassium and/or sodium hydroxide yielding a product that contains Glycerine monostearate as well as potassium stearate and/or sodium stearate. Glycerine monostearate is the natural glyceryl ester of glycerin and stearic acid. It offers excellent hydration and moisturization. It acts as a non-ionic opacifier, thickener, emollient and formulation stabilizer. It is used in skin care and body care applications. Glycerine monostearate is classified as : Emollient Emulsifying Learn all about Glycerine monostearate, including how it's made, and why Puracy uses Glycerine monostearate in our products. Derived from: coconut Pronunciation: (\ˈglis-rəl\ \stē-ə-ˌrāt\) Type: Naturally-derived Other names: monostearate What Is Glycerine monostearate? Glycerine monostearate, also called Glycerine monostearate, is a white or pale yellow waxy substance derived from palm kernel, olives, or coconuts. What Does Glycerine monostearate Do in Our products? Glycerine monostearate is an emollient that keeps products blended together; it can also be a surfactant, emulsifier, and thickener in food — often it’s used as a dough conditioner and to keep things from going stale.[1] In our products, however, Glycerine monostearate is used for its most common purpose — to bind moisture to the skin. For this reason, it is a common ingredient in thousands of cosmetic products, including lotions, makeup, skin cleansers, and other items.[2,3] Why Puracy Uses Glycerine monostearate We use Glycerine monostearate in several of our products as a moisturizer; it also forms a barrier on the skin and prevents products from feeling greasy. As an emulsifier, it also allows products to stay blended.[5] Several studies and clinical tests find that Glycerine monostearate causes little or no skin or eye irritation and is not a danger in formulations that might be inhaled.[6,7,8] In addition, a number of clinical trials have found that Glycerine monostearate in moisturizers can lessen symptoms and signs of atopic dermatitis, including pruritus, erythema, fissuring, and lichenification.[9] In 1982 and again in 2015, the Cosmetic Ingredient Review deemed the ingredient safe for use in cosmetics.[10] Whole Foods has deemed the ingredient acceptable in its body care quality standards. How Glycerine monostearate Is Made Glycerine monostearate is formed through a reaction of glycerin with stearic acid, which is a fatty acid that comes from animal and vegetable fats and oils. Glycerine monostearate SE, the self-emulsifying form of the substance, is made by reacting an excess of stearic acid with glycerin. The excess stearic acid is then reacted with potassium and/or sodium hydroxide. That produces a substance that contains Glycerine monostearate, potassium stearate, and/or sodium stearate. Glyceryl stearate (Glycerine monostearate) is one of the most commonly used ingredients in personal care formulations. But it’s a material that is not well understood by most formulators. Glycerine monostearate (EU) is normally used as a low-HLB thickening agent in lamellar gel (EU) network (LGN)-based oil-in-water emulsions, often combined with fatty alcohols. LGN-based emulsions containing thickening polymers are the most common type of oil-in-water formulations sold globally. Most Glycerine monostearate used in personal care products should actually be called glyceryl distearate (EU), since many common grades only contain around 40% alpha monostearate (EU), 5% glyceryl tristearate (EU), and 50% glyceryl distearate. There are also grades commercially available that contain 30%, 60%, and 90% Glycerine monostearate. The 90% alpha mono grades can only be produced by molecular distillation and are widely used in the food industry. Functionally, there is a big difference in performance if you use a 90% versus 40% mono. A 90% mono has a higher melting point (69°C versus 58-63°C), lighter skin feel, and a higher HLB (EU) (~4-5, versus ~3). The higher HLB of the 90% mono enables you to form LGNs much easier with lower emulsifier levels and energy than when using cetyl (EU)/stearyl alcohol (EU). There are also self-emulsifying (SE) grades of Glycerine monostearate available, which are typically combined with PEG 100 stearate (EU), potassium stearate (EU), or sodium lauryl sulfate (EU). Glycerine monostearate Glycerine monostearate is created by the esterification of glycerin and stearic acid. Glycerine monostearate creates an excellent emulsion and when used in combination with other emulsifiers, creates a stable lotion. Characteristics An interesting characteristic of Glycerine monostearate is the ability to make the oils which are combined in the emulsion non greasy, so for example Sunflower can be combined, without adding greasiness to the final product, allowing creams and lotions to be produced which carry the properties of the oil without the greasiness. Glycerine monostearate can be used to pearlise shower gel, shampoo and hand wash if added in combination with glycerine. How to use Heat the Glycerine monostearate to 60c - 70c within the oil stage of your formulations. Ensure the Glycerine monostearate is fully dissolved into your oil stage (use agitation if required) in order to minimise the risk of graininess in your final formulation. Precautions At pure usage levels it can cause irritation to the skin. When blending always take the following precautions: Use gloves (disposable are ideal) Take care when handling hot oils Wear eye protection Work in a well ventilated room Keep ingredients and hot oils away from children If ingested, seek immediate medical advice If contact made with eyes, rinse immediately with clean warm water and seek medical advice if in any doubt. Safety First In addition to our precautions and general safety information, we always recommend keeping a first aid kit nearby. You are working with hot water and oils, accidents can happen, so always be prepared! Is Glycerine monostearate Safe? Toxicity The safety of PEG compounds has been called into question in recent years. The questioning of the safety of this ingredient is due to toxicity concerns that result from impurities found in PEG compounds. The impurities of concern are ethylene oxide and 1,4 dioxane, both are by-products of the manufacturing process. Both 1,4 dioxane and ethylene oxide have been suggested to be linked with breast and uterine cancers. While these impurities may have been a concern previously, ingredient manufacturers and improved processes have eliminated the risk of impurities in the final product. The level of impurities that were found initially in PEG manufacturing was low in comparison to the levels proposed to be linked to cancers. Longitudinal studies or studies over a long period of use of PEG compounds have not found any significant toxicity or any significant impact on reproductive health. When applied topically, Glycerine monostearate is not believed to pose significant dangers to human health. It doesn’t penetrate deeply into the skin and isn’t thought to have bioaccumulation concerns when used topically. Irritation Through research, PEG compounds have exhibited evidence that they are non-irritating ingredients to the eyes or the skin. This research used highly concentrated forms of the ingredient, concentrations that would not be found in your skincare products. The Cosmetic Ingredient Review Expert Panel found PEG compounds to be non-photosensitizing and non-irritating at concentrations up to 100%. However, despite the evidence suggesting that PEG compounds are non-irritating, some research has indicated that irritation can occur when the skin is broken or already irritated. In a study that was trialing the use of PEG containing antimicrobial cream on burn patients, some patients experienced kidney toxicity. The concentration of PEG compounds was identified to be the culprit. Given that there was no evidence of toxicity in any study of PEGs and intact skin, the Cosmetic Ingredient Review Expert Panel amended their safety guidelines to exclude the use of PEG containing products on broken or damaged skin. Is Glycerine monostearate Vegan? Depending on the source of the stearic acid used to make Glycerine monostearate, it may be vegan. Most of the time, stearic acid is derived from plants. However, it can also be derived from animal origin. If it is of animal origin, the product has to comply with animal by-product regulation. Check with the brand you are thinking of using to determine whether their Glycerine monostearate is derived from a plant or animal source. Why Is Glycerine monostearate Used? Emulsifier Glycerine monostearate is included in skincare and beauty products for a variety of reasons, ranging from making the skin softer to helping product formulations better keep their original consistency. As an emollient, Glycerine monostearate is included within skincare product formulations to give the skin a softer feel. It achieves this through strengthening the skin’s moisture barrier by forming a thin fatty layer on the skin’s surface, which prevents moisture loss and increases overall hydration. This moisturizing effect increases the hydration of skin cells, which in turn makes the skin softer and boosts skin health. Texture Another use for Glycerine monostearate has to do with its emulsification properties. Emulsifiers are valued in the skincare and personal care industries because of their ability to mix water and oils. Without this ability, the oils in many formulations would begin to separate from the water molecules, thus undermining product texture and consistency. Glycerine monostearate is also used to help to cleanse through mixing oil and dirt so that it can be rinsed away. Surfactant Lastly, Glycerine monostearate can also act as a surfactant, when used in body and facial cleansers. Surfactants disrupt surface tension, helping to mix water and oil. This characteristic helps the ingredient cleanse the skin by mixing oil with water, lifting dirt trapped inside the skin’s oils, and rinsing it away from the skin. What Types of Products Contain Glycerine monostearate? There are many products in the skin and personal care industry that are formulated with Glycerine monostearate because of its benefits to formulations and its relative safety. Facial cleansers, shampoos, lotions, and face creams have all been known to contain this ingredient. If you’ve had problems with this ingredient before, or if your doctor has advised you to stay away from Glycerine monostearate, it’s vital to read ingredient labels for any personal care product as it has many applications. What are PEGs? You have probably noticed that many of cosmetics and personal care products you use have different types of PEGs among ingredients. PEG, which is the abbreviation of polyethylene glycol, is not a definitive chemical entity in itself, but rather a mixture of compounds, of polymers that have been bonded together. Polyethylene is the most common form of plastic, and when combined with glycol, it becomes a thick and sticky liquid. PEGs are almost often followed by a number, for example PEG-6, PEG-8, PEG 100 and so on. This number represents the approximate molecular weight of that compound. Typically, cosmetics use PEGs with smaller molecular weights. The lower the molecular weight, the easier it is for the compound to penetrate the skin. Often, PEGs are connected to another molecule. You might see, for example, Glycerine monostearate as an ingredient. This means that the polyethylene glycol polymer with an approximate molecular weight of 100 is attached chemically to stearic acid. In cosmetics, PEGs function in three ways: as emollients (which help soften and lubricate the skin), as emulsifiers (which help water-based and oil-based ingredients mix properly), and as vehicles that help deliver other ingredients deeper into the skin. What effect do Glycerine monostearate have on your skin? Polyethylene glycol compounds have not received a lot of attention from consumer groups but they should. The most important thing to know about PEGs is that they have a penetration enhancing effect, the magnitude of which is dependent upon a variety of variables. These include: both the structure and molecular weight of the PEG, other chemical constituents in the formula, and, most importantly, the overall health of the skin. PEGs of all sizes may penetrate through injured skin with compromised barrier function. So it is very important to avoid products with PEGs if your skin is not in best condition. Skin penetration enhancing effects have been shown with PEG-2 and PEG-9 stearate. This penetration enhancing effect is important for three reasons: 1) If your skin care product contains a bunch of other undesirable ingredients, PEGs will make it easier for them to get down deep into your skin. 2) By altering the surface tension of the skin, PEGs may upset the natural moisture balance. 3) Glycerine monostearate are not always pure, but often come contaminated with a host of toxic impurities. Emulsifiers Emulsifiers are used to aid the incorporation and stabilization of air bubbles in the batter, especially in the presence of fats or oils. The most commonly used emulsifiers for this purpose are glycerol monostearate (Glycerine monostearate) and polyglycerol esters, with the former being the more effective of the two on a weight-for-weight basis. Both emulsifiers are commonly used in a paste form, i.e., dispersed in water with other ingredients which promote gel stability. Emulsifiers like Glycerine monostearate may exist in a number of forms when dispersed in water and it is important it is in the active alpha-gel form when used for cake making. Without Glycerine monostearate the egg protein will largely stabilize the air bubbles and the sponge will have a reasonable volume, but often with an area of coarse open-cell structure in the crumb. The addition of a small level of Glycerine monostearate somewhat unexpe
GLYCEROL MONOLAURATE (GML)
Glycerol monolaurate (GML) is a broadly antimicrobial fatty acid monoester, killing bacteria, fungi, and enveloped viruses.
Glycerol monolaurate (GML) is an organic compound that belongs to the class of monoglycerides, specifically a monoglyceride ester.
Glycerol monolaurate (GML) is a fatty acid monoglyceride, which richly exists in coconut oil, palm oil, and human milk.

CAS Number: 27215-38-9
Molecular Formula: C15H30O4
Molecular Weight: 274.4
EINECS Number: 248-337-4

Glycerol monolaurate (GML) is composed of glycerol (also known as glycerin) and lauric acid.
Glycerol monolaurate (GML) is a saturated fatty acid commonly found in coconut oil and palm kernel oil.
Glycerol monolaurate (GML) is a 1-monoglyceride with dodecanoyl (lauroyl) as the acyl group.

Glycerol monolaurate (GML) (abbreviated GML; also called Monolaurin, glyceryl laurate, and 1-lauroyl-glycerol) is a monoglyceride.
Glycerol monolaurate (GML) is the mono-ester formed from glycerol and lauric acid.
Glycerol monolaurate (GML) is chemical formula is C15H30O4.

Glycerol monolaurate (GML) is found in coconut oil and may be similar to other monoglycerides found in human breast milk.
Glycerol monolaurate (GML) can be ingested in coconut oil and the human body converts it into monolaurin.
Furthermore, coconut oil, coconut cream, grated coconut and others products are sources of lauric acid and, consequently, monolaurin.

Glycerol monolaurate (GML) is a naturally occurring fatty acid widely utilized in food, cosmetics, and homeopathic supplements.
Glycerol monolaurate (GML) is a potent antimicrobial agent that targets a range of bacteria, fungi, and enveloped viruses but select findings suggest that Glycerol monolaurate (GML) also has immunomodulatory functions.
Glycerol monolaurate (GML) is a naturally occurring fatty acid which is commonly used in food, cosmetics, and homoeopathic supplements.

Glycerol monolaurate (GML) is considered as an effective antibacterial drug that kills a variety of bacteria, fungi, and enveloped viruses.
This offering is a naturally occurring fatty acid molecule and antibacterial agent which acts as an ingredient in several goods, including deodorants, lotions, and cosmetics.
Glycerol monolaurate (GML) GML is highly effective food preservative and emulsifier.

The said product is also widely accessible as a homoeopathic supplement.
Glycerol monolaurate (GML) is a naturally occurring surfactant that has potential use as an additive to tampons and wound dressings to reduce the incidence of certain bacterial toxin-mediated illnesses.
Glycerol monolaurate (GML) emulsifier for sale is a versatile ingredient that has many applications in the food industry.

Glycerol monolaurate (GML) can be used as an emulsifier, antimicrobial, texture enhancer, flavor enhancer, and clean-label ingredient and is found in a wide range of products, including baked goods, dairy products, and beverages.
Glycerol monolaurate (GML)'s versatility makes it an ideal ingredient for many different types of foods, and its natural properties make it a safe and healthy choice.
Glycerol monolaurate (GML) is an advanced food emulsifiers preservatives nowadays, exists in breast milk naturally ,and it is recognized as a fine food emulsifier internationally.

Glycerol monolaurate (GML) is a safe, effective, broad-spectrum antibacterial agent.
Glycerol monolaurate (GML) is LD50> 10g/kg, is a non-toxic food additive.
In April 2005, Chinese Ministry of Health approved that GML can be used in all kinds of food, and no dosage limit, it can be added according to actual needs.

The biggest advantage of Glycerol monolaurate (GML) is the "not preservatives, but more than preservative".
Glycerol monolaurate (GML) is bacteriostatic effect will not change with the change of pH value supose pH value is within the scope of 4 ~ 8.
Glycerol monolaurate (GML) is antibacterial spectrum was wide, it has strong interaction in the common bacteria, fungi, yeast in food, and also can inhibit variety of viruses and protozoa.

Glycerol monolaurate (GML) is an antimicrobial agent that has potent activity against gram-positive bacteria.
This study examines GML antibacterial activity in comparison to lauric acid, in broth cultures compared to biofilm cultures, and against a wide range of gram-positive, gram-negative, and non-gram staining bacteria.
Glycerol monolaurate (GML) 90% min is an advanced food emulsifiers preservatives nowadays, exists in breast milk naturally .

Glycerol monolaurate (GML) it is recognized as a fine food emulsifier internationally.
Glycerol monolaurate (GML) is a safe, effective, broad-spectrum antibacterial agent.
In April 2005, Chinese Ministry of Health approved that GML can be used in all kinds of food, and no dosage limit, it can be added according to actual needs.

Glycerol monolaurate (GML) (GB15612-95 (GML-90)) is in the form of milky white beads or powder.
Glycerol monolaurate (GML) has a monoglyceride content of 90-95%.
Glycerol monolaurate (GML) can be used to prevent dough from aging, provide foaming stability, and improve texture, stability, and taste.

Glycerol monolaurate (GML) can be used in breads, flour products, peanut butter, and beverages.
Glycerol monolaurate (GML) Glycerol Laurate E471 (GML) CAS No.:142-18-7 is not merely an excellent emulsifier,but also a safe and efficient antibacterial agent with wide spectrum and it is also not limited by pH value.
In the condition of neutral or slightly alkaline conditions,it still has a good antibacterial effect.

Glycerol monolaurate (GML) is a compound that has gained significant attention in recent years.
As more and more people are following gluten-free diets, there is a growing concern whether or not GML is gluten-free.
In this article, will delve into the world of Glycerol monolaurate (GML) and gluten, exploring the chemical composition of Glycerol monolaurate (GML), its common uses, the concept of gluten-free, and the connection between GML and gluten.

Glycerol monolaurate (GML), also known as dodecanoic acid monoglyceride, is an esterophilic nonionic surfactant that is naturally found in breast milk, coconut oil, and American sylvestris.
The food emulsifier has an HLB value of 5.2 and is a safe, efficient and broad-spectrum bacteriostatic agent with dual functions of emulsifying and antiseptic.
Glycerol monolaurate (GML) is used as a surfactant, preservative and emulsifier in food, besides it can be used in cosmetics and medicines.

This study obtained to optimize Glycerol monolaurate (GML) synthesis from glycerol and lauric acid. It consisted of two steps, dealumination of zeolite Y catalyst and optimization of GML synthesis.
Glycerol monolaurate (GML), is glyceryl laurate or 1-lauroyl-glycerol, is a monoglyceride.
Glycerol monolaurate (GML) is shortly termed as GML.

Glycerol monolaurate (GML) is the mono-ester derived from glycerol and lauric acid.
Glycerol monolaurate (GML) is also widely known as monolaurin.
Chemical formula of Glycerol monolaurate (GML) is C15H30O4.

Glycerol monolaurate (GML) is a naturally occurring fatty acid that has wide range of application in food, cosmetics, personal care and homeopathic supplements.
Glycerol monolaurate (GML) is a broadspectrum antimicrobial agent that has effective reaction against the grampositive bacteria and targets a variety of bacteria, fungi, and enveloped viruses.
Glycerol monolaurate (GML) is a type of lipophilicity nonionic surfactant, which naturally exists in breast milk and palmetto, a type of palm tree.

Glycerol monolaurate (GML) well-known as a good food emulsifier and also a safe and efficient antibacterial agent.
Glycerol monolaurate (GML) has a glycerol molecule attached to a single lauric acid molecule through an ester linkage.
Glycerol monolaurate (GML) is typically a white to light yellowish solid or a waxy substance.

Glycerol monolaurate (GML) is soluble in fats and oils but has limited solubility in water.
Glycerol monolaurate (GML) is known for its antimicrobial properties. It exhibits inhibitory effects against various microorganisms, including bacteria, viruses, and fungi.
This makes it useful in applications where microbial contamination needs to be controlled.

Glycerol monolaurate (GML) is commonly used as an emulsifier and stabilizer in the food and cosmetic industries.
Glycerol monolaurate (GML) helps improve the texture and shelf life of certain products by preventing the separation of water and oil phases.
Due to its antimicrobial properties, Glycerol monolaurate (GML) is utilized in food preservation to inhibit the growth of bacteria and extend the shelf life of certain food products, especially those prone to microbial spoilage.

Glycerol monolaurate (GML) is found in various personal care products, such as creams, lotions, and cosmetics, where it serves as an emulsifier and stabilizing agent.
Glycerol monolaurate (GML) has been studied for its potential applications in medicine.
Glycerol monolaurate (GML) has shown promise in inhibiting the growth of certain pathogenic bacteria and viruses, making it a subject of interest in the development of antimicrobial agents.

Glycerol monolaurate (GML) is available as a dietary supplement and is sometimes marketed for its potential health benefits, including immune system support.
Glycerol monolaurate (GML) is a broadly antimicrobial fatty acid monoester, killing bacteria, fungi, and enveloped viruses.
Glycerol monolaurate (GML) is a 1-monoglyceride and a dodecanoate ester.

Melting point: 50 °C
storage temp.: −20°C
LogP: 4.029 (est)
FDA UNII: Y98611C087

Glycerol monolaurate (GML) is a kind of broad antibiotic, which is safe, efficient and extensive.
Glycerol monolaurate (GML) can inhibit some kinds of virus and a lot of bacteria and bioplasm.
Glycerol monolaurate (GML) is better than pentadiene carboxylic acid, benzene carboxylic acid and P-hydroxy benzoic acid ester.

Glycerol monolaurate (GML) is insoluble in water and has emulsifying and lubricating properties.
Widely used in food, cosmetics, textiles, leather, and other industries.
Glycerol monolaurate (GML) antiviral mechanism is that lauric acid can cause viral membrane protein leakage, monolaurate can be inserted into the membrane of the virus, both of which lead to reduced or loss of replication.

Glycerol monolaurate (GML) is commonly said that monoglyceride destroys the membrane structure of the virus and inhibits its ability to replicate, that is, it leaves the virus in a half-dead resting state, in which the non-replicating virus acts as an antigen and stimulates the production of corresponding antibodies in animals.
Several studies have illustrated that GML is ≥ 200 times more effective in bactericidal activities or several chemical reactions than lauric acid.

Some cliquey reports and findings have illuminated that Glycerol monolaurate (GML) also has immunomodulatory functions.
A few detailed researches have shed light on an astonishing research which reveals that the widely used anti-microbial agent Glycerol monolaurate (GML) also alters the lipid dynamics of human T cells, leading to their defective signaling and function.
Glycerol monolaurate (GML) is chemical having potent antimicrobial properties and so has a wide range of applications pharmaceutical or healthcare sectors for medical and sterilizing purposes.

Along with this, Glycerol monolaurate (GML) is a well-known food emulsifier thus, witnessing demand of product from food or dietary sectors.
In recent years, Glycerol monolaurate (GML) is also being majorly used to make a number of cosmetics and beauty care products, due to its antibacterial, antifungal, etc. properties.
Glycerol monolaurate (GML) is a fascinating compound that occurs naturally in coconuts and breast milk.

Glycerol monolaurate (GML) is a monoester of lauric acid and glycerol, which gives it unique properties and makes it highly versatile in various industries.
Glycerol monolaurate (GML) is composed of a glycerol molecule esterified with a single lauric acid molecule.
This means that GML consists of one Glycerol monolaurate (GML) and one lauric acid molecule bonded together.

This unique molecular structure is what gives Glycerol monolaurate (GML) its distinct properties and makes it an excellent emulsifier and preservative.
Glycerol monolaurate (GML) is used as an emulsifier, it helps blend oil and water-based ingredients together, creating a smooth and stable mixture.
This property is highly valued in the food and cosmetic industries, where Glycerol monolaurate (GML) is extensively used to improve the texture and stability of various products.

Glycerol monolaurate (GML)'s antimicrobial properties make it an effective preservative.
Glycerol monolaurate (GML) has the ability to inhibit the growth of certain bacteria and fungi, making it an ideal choice for extending the shelf life of food and cosmetic products.
Glycerol monolaurate (GML) interacts with lipids, and its antimicrobial properties are attributed to its ability to disrupt the lipid bilayers of microbial cell membranes.

This disruption can lead to the inhibition of microbial growth.
Glycerol monolaurate (GML) acts as a stabilizing agent in certain food products, preventing the separation of oil and water phases.
This property is particularly useful in emulsified products like salad dressings and mayonnaise.

Glycerol monolaurate (GML), is naturally found in coconut oil and palm kernel oil.
Glycerol monolaurate (GML) derived from these sources is sometimes preferred for products marketed as natural or organic.
Glycerol monolaurate (GML) may have antiviral properties, making it a subject of interest in the development of interventions against certain viruses.

Glycerol monolaurate (GML) has been studied in the context of viral infections, including those caused by enveloped viruses.
Some studies have explored the anti-inflammatory effects of Glycerol monolaurate (GML).
Glycerol monolaurate (GML) may modulate immune responses and inflammatory processes, making it potentially relevant in conditions associated with inflammation.

Glycerol monolaurate (GML) is employed as a preservative in certain food products, helping to inhibit the growth of spoilage microorganisms and extending the product's shelf life.
Due to its emulsifying and stabilizing properties, Glycerol monolaurate (GML) is utilized in skin care products. It may contribute to the overall texture and stability of creams and lotions.
Glycerol monolaurate (GML) can be compatible with other food additives, such as antioxidants and preservatives, enhancing its effectiveness in food preservation.

Some studies have explored Glycerol monolaurate (GML)'s potential in modulating the immune system, making it an area of interest in immunology research.
The regulatory status of Glycerol monolaurate (GML) varies by region, and it is important for manufacturers to comply with local regulations and safety standards when using Glycerol monolaurate (GML) in food, cosmetics, or other products.
Glycerol monolaurate (GML) has demonstrated antifungal properties in some studies.

This makes it relevant in inhibiting the growth of certain fungi, extending its potential applications to products where fungal contamination is a concern.
Glycerol monolaurate (GML) is sometimes incorporated into animal feed as an antimicrobial agent to help control microbial growth and improve feed hygiene.
Glycerol monolaurate (GML) is effective in stabilizing water-in-oil emulsions, a property that finds application in various food and cosmetic formulations.

In some applications, Glycerol monolaurate (GML) may exhibit synergistic effects when combined with other antimicrobial agents.
This can enhance its overall effectiveness in inhibiting microbial growth.
Some research suggests that Glycerol monolaurate (GML) may influence biofilm formation, a consideration in environments where microbial biofilms can lead to contamination or product spoilage.

Glycerol monolaurate (GML) is generally considered biodegradable, contributing to its environmentally friendly profile compared to some synthetic additives.
Glycerol monolaurate (GML)'s surfactant properties make it suitable for use in certain detergent formulations, contributing to emulsification and stabilization.
In addition to its use in cosmetics, Glycerol monolaurate (GML) may be found in topical formulations for its potential antimicrobial and anti-inflammatory effects on the skin.

Glycerol monolaurate (GML) has been explored in encapsulation technologies, where it can be used to encapsulate and deliver bioactive compounds in a controlled manner.
Glycerol monolaurate (GML) is effective against a broad spectrum of microorganisms, it's essential to be aware that some microorganisms may develop resistance over time, highlighting the importance of responsible and judicious use.
Some studies have investigated the impact of Glycerol monolaurate (GML) on gut health.

Glycerol monolaurate (GML) may influence the gut microbiota and potentially offer benefits in maintaining a balanced microbial environment.
Ongoing research explores the therapeutic potential of Glycerol monolaurate (GML) in various health conditions, including its antimicrobial, anti-inflammatory, and immunomodulatory properties.

Uses:
Glycerol monolaurate (GML) is a monoglyceride emulsifier produced by the esterification of glycerin and lauric acid.
Glycerol monolaurate (GML) has a melting point of 56°c, a maximum iodine value of 0.5, and a saponification value of 200–206.
In a highly purified form, it shows antimicrobial properties against microorganisms with the exception of gram-negative organisms.

Glycerol monolaurate (GML) is effective against gram-negative organisms when formulated with bha or edta.
Glycerol monolaurate (GML) is used in baked goods, whipped toppings, frosting, glazes, and cheese products.
Glycerol monolaurate (GML) is most commonly used as a surfactant in cosmetics, such as deodorants.

As a food additive Glycerol monolaurate (GML) is also used as an emulsifier or preservative.
Glycerol monolaurate (GML) is also marketed as a dietary supplement.
Glycerol monolaurate (GML) exists in breast milk, having the ability of resist pathogenic microbe inflection, extensively be applied in the infant milk powder, rice flour etc.

Glycerol monolaurate (GML) is explored in the development of medical and health products due to its potential antimicrobial properties.
Glycerol monolaurate (GML) may find applications in wound care and other medical formulations.
Glycerol monolaurate (GML) has been studied for its impact on biofilm formation.

Glycerol monolaurate (GML) may serve as an anti-biofilm agent, which is important in preventing the formation of bacterial biofilms in various settings.
Some research suggests that GML exhibits anti-inflammatory effects.
This property may be relevant in formulations aimed at addressing inflammatory conditions.

Glycerol monolaurate (GML)'s antimicrobial properties make it a potential ingredient in oral care products, such as toothpaste and mouthwash, for its role in inhibiting the growth of oral bacteria.
Glycerol monolaurate (GML) is investigated for its biomedical applications, including its use in biomaterials and coatings to prevent microbial contamination and biofilm formation on medical devices.

In food packaging materials, Glycerol monolaurate (GML) may be incorporated to provide antimicrobial protection, helping to prevent the growth of spoilage microorganisms and enhance the safety of packaged food.
Glycerol monolaurate (GML), as a dietary supplement, may be considered for its potential role in supporting the immune system and overall health.
Glycerol monolaurate (GML) is sometimes included in formulations aimed at dietary management.

In the oil and gas industry, Glycerol monolaurate (GML) may be explored for its antimicrobial properties to control microbial growth in various processes and equipment.
Glycerol monolaurate (GML)'s properties may be harnessed in anti-corrosion formulations to inhibit microbial-induced corrosion in certain industrial settings.
Glycerol monolaurate (GML) is used in the beverage industry to prevent microbial contamination and enhance the shelf life of beverages, such as juices and sports drinks.

Glycerol monolaurate (GML) may be incorporated into pet care products, such as shampoos and grooming items, for its emulsifying and stabilizing properties.
In agriculture, Glycerol monolaurate (GML) may be explored for its potential role in plant protection, controlling microbial growth in certain agricultural formulations.
Glycerol monolaurate (GML)'s biodegradable nature may be considered in environmental remediation efforts, where it could potentially contribute to the management of microbial populations in contaminated environments.

Glycerol monolaurate (GML) mechanism is that lauric acid can cause viral membrane protein leakage, monolaurate can be inserted into the membrane of the virus, both of which lead to reduced or loss of replication.
Glycerol monolaurate (GML) is commonly said that monoglyceride destroys the membrane structure of the virus and inhibits its ability to replicate, that is, it leaves the virus in a half-dead resting state, in which the non-replicating virus acts as an antigen and stimulates the production of corresponding antibodies in animals.
Glycerol monolaurate (GML) is used in baked product extensively, having the function for increase the quality of rice and flour production.

Glycerol monolaurate (GML) in capsule form as a dietary supplement.
Glycerol monolaurate (GML) is sold as a dietary supplement and as an ingredient in certain foods.
The United States Food and Drug Administration categorizes it as generally recognized as safe.

Glycerol monolaurate (GML) is used as an emulsifier in sanitarian foods and other foods such as bread, cake, streamed bread and moon-cake.
Glycerol monolaurate (GML) is used in meat product, dairy product, spicy products and fruit and vegetable for make the time of preservation longer.
Glycerol monolaurate (GML) 90% is used to improve the texture and uniformity of baked goods like cakes, bread, and pastries.

Glycerol monolaurate (GML) is often used to increase the stability of dairy products such as cheese, cream, and ice cream.
Glycerol monolaurate (GML) plays a significant role in the food industry, where it is widely used as a food additive and preservative.
In addition to its applications in the food industry, Glycerol monolaurate (GML) is also utilized in the production of cosmetics and personal care products.

Glycerol monolaurate (GML) can be found in items such as lotions, creams, and soaps, where it acts as an emulsifier, helping to blend different ingredients together and create stable formulations.
Glycerol monolaurate (GML) even finds its way into animal feeds. Its antimicrobial properties make it a valuable additive in animal nutrition, helping to protect animals from harmful bacteria and fungi that can affect their health and well-being.
Glycerol monolaurate (GML) is used as an emulsifier to create uniformity and to keep the product from separating.

Glycerol monolaurate (GML) is used to improve the texture and mouthfeel of snack foods, such as cookies, crackers, and candy.
Glycerol monolaurate (GML) is used in sports drinks and protein shakes to prevent separation and improve the mouthfeel.
Glycerol monolaurate (GML) is used in salad dressings, mayonnaise, and sauces to improve the emulsification and texture.

Glycerol monolaurate (GML) is used as an antimicrobial agent in food products to inhibit the growth of spoilage microorganisms, extending the shelf life of items like baked goods, dairy products, and beverages.
Glycerol monolaurate (GML) acts as an emulsifier and stabilizer in food products, particularly in items where oil and water need to be combined and maintained in a stable state, such as salad dressings and mayonnaise.
Glycerol monolaurate (GML) is utilized in cosmetics and personal care products as an emulsifying agent to blend water and oil-based ingredients, enhancing product stability and texture.

Glycerol monolaurate (GML) helps stabilize formulations, preventing separation of components and maintaining product integrity.
Glycerol monolaurate (GML) is added to animal feed as an antimicrobial agent to control microbial growth and improve the hygiene of the feed, contributing to animal health.
Glycerol monolaurate (GML) is explored for use in pharmaceuticals and drug delivery systems, particularly in encapsulation technologies where it can encapsulate and release bioactive compounds.

Glycerol monolaurate (GML) may be found in topical formulations, such as creams and lotions, for its potential antimicrobial and anti-inflammatory effects on the skin.
Glycerol monolaurate (GML)'s surfactant properties make it suitable for use in certain detergent formulations, contributing to emulsification and stabilization.
Glycerol monolaurate (GML) is available as a dietary supplement, marketed for its potential health benefits, including immune system support.

Glycerol monolaurate (GML)'s potential therapeutic applications, including its antimicrobial, anti-inflammatory, and immunomodulatory properties.
Glycerol monolaurate (GML) may be explored for its antimicrobial properties in water treatment processes to control bacterial contamination.
Glycerol monolaurate (GML) is generally considered biodegradable, contributing to its use in formulations where environmental considerations are important.

Glycerol monolaurate (GML) is involved in encapsulation technologies, where it can be utilized to encapsulate and deliver bioactive compounds in controlled-release systems.
Ongoing studies investigate Glycerol monolaurate (GML)'s impact on gut health, influencing the gut microbiota and potentially offering benefits in maintaining a balanced microbial environment.
Glycerol monolaurate (GML) has been studied for its potential antiviral properties.

Research suggests Glycerol monolaurate (GML) may have inhibitory effects on certain viruses, making it a subject of interest in antiviral formulations.
Glycerol monolaurate (GML) is utilized as a food additive in various food products.
Glycerol monolaurate (GML) may serve multiple functions, including emulsification, stabilization, and as an antimicrobial agent for food preservation.

Glycerol monolaurate (GML) may be included in the formulation of functional foods, where its potential health benefits, such as antimicrobial and anti-inflammatory properties, can contribute to the overall functionality of the product.
Due to its antimicrobial properties, Glycerol monolaurate (GML) may find application in air fresheners and deodorizers to inhibit the growth of odor-causing bacteria.
Glycerol monolaurate (GML) is investigated for its potential use in biomedical coatings to prevent microbial contamination on surfaces of medical devices and implants.

In the oil and gas industry, Glycerol monolaurate (GML) may be explored for its ability to control microbial growth in oilfield processes, pipelines, and equipment.
Glycerol monolaurate (GML) is studied for its potential use in the poultry industry to control bacterial contamination and improve hygiene in poultry feed and processing.
Glycerol monolaurate (GML) may be considered in the plastic industry for its potential antimicrobial properties, contributing to the development of antimicrobial plastics in various applications.

Glycerol monolaurate (GML)'s antimicrobial properties may be explored in pesticide formulations to enhance their efficacy and control microbial populations in agricultural settings.
In industrial applications such as metalworking, Glycerol monolaurate (GML) may be considered for its potential use in metalworking fluids to inhibit microbial growth and prevent degradation.
Glycerol monolaurate (GML) can be used in the textile industry as an antimicrobial agent, contributing to the development of textiles with enhanced resistance to microbial growth and odors.

Glycerol monolaurate (GML) may be incorporated into anti-acne formulations in skincare products due to its antimicrobial properties, potentially aiding in the control of acne-causing bacteria.
Glycerol monolaurate (GML)'s emulsifying properties make it suitable for use in water-based coatings, contributing to stability and performance in various coating applications.
Glycerol monolaurate (GML)'s stability and antimicrobial properties may be explored in heat transfer fluids, contributing to the prevention of microbial contamination in industrial heat exchange systems.

Safety Profile:
Glycerol monolaurate (GML) may cause irritation to the skin and eyes, especially in its pure form or at high concentrations.
Direct contact with the skin or eyes should be avoided, and appropriate personal protective equipment, such as gloves and safety goggles, should be used.
Inhalation of Glycerol monolaurate (GML) dust or vapors may lead to respiratory irritation.

Adequate ventilation is important in areas where GML is handled to minimize the risk of inhalation exposure.
Glycerol monolaurate (GML) is generally regarded as safe for consumption in regulated amounts, ingesting large quantities could lead to gastrointestinal discomfort.
Ingestion should be avoided, and Glycerol monolaurate (GML)-containing products should be used according to recommended guidelines.

Some individuals may be sensitive or allergic to Glycerol monolaurate (GML), and exposure could lead to allergic reactions.
Glycerol monolaurate (GML)'s important to be aware of any known allergies or sensitivities when using products containing Glycerol monolaurate (GML).

Environmental Impact:
Glycerol monolaurate (GML) is considered biodegradable, but large spills or improper disposal could have environmental consequences.
Glycerol monolaurate (GML)'s important to follow proper waste disposal procedures in accordance with local regulations.
Glycerol monolaurate (GML) may release products that could be harmful.

Synonyms:
Monolaurin
2,3-Dihydroxypropyl dodecanoate
142-18-7
1-Monolaurin
Glyceryl monolaurate
Lauricidin
GLYCERYL LAURATE
1-Glyceryl laurate
Glycerol 1-laurate
27215-38-9
1-Monolauroyl-rac-glycerol
1-Monododecanoylglycerol
Glycerol monolaurate (GML)
Laurin, 1-mono-
Glycerin 1-monolaurate
Glycerol 1-monolaurate
Lauric acid 1-monoglyceride
Dodecanoic acid, 2,3-dihydroxypropyl ester
2,3-Dihydroxypropyl laurate
Glyceryl monododecanoate
1-Lauroyl-rac-glycerol
DL-alpha-Laurin
Glycerides, C12-18
.alpha.-monolaurin
67701-26-2
3-Dodecanoyloxy-1,2-propanediol
(+-)-Glyceryl 1-monododecanoate
Dodecanoic acid alpha-monoglyceride
glyceryl 1-laurate
Glycerin monolaurate
(+-)-2,3-Dihydroxypropyl dodecanoate
Dodecanoic acid, monoester with 1,2,3-propanetriol
Glycerol .alpha.-monolaurate
WR963Y5QYW
40738-26-9
DTXSID5041275
CHEBI:75543
Lauric acid .alpha.-monoglyceride
1-Monolaurin;1-Lauroyl-rac-glycerol
Lauric acid, monoester with glycerol
Dodecanoic acid .alpha.-monoglyceride
NSC698570
NSC-698570
NCGC00164528-01
alpha-Monolaurin
1-monolauroylglycerol
DTXCID3021275
Glucerol alpha-monolaurate
Monolauroylglycerin
CAS-142-18-7
Lauric acid alpha-monoglyceride
C15H30O4
EINECS 205-526-6
UNII-WR963Y5QYW
Lauricidin R
Cithrol GML
rac-1-monolaurin
MG 12:0
Hodag GML
Glycerox L 8
Lauricidin 802
Lauricidin 812
1-dodecanoylglycerol
EINECS 266-944-2
Grindtek ML 90
Dimodan ML 90
Imwitor 312
Sunsoft 750
Sunsoft 757
Monomuls 90L12
rac-1-lauroylglycerol
Aldo MLD-K-FG
Glycerol 1-dodecanoate
Tegin L 90
rac-1-dodecanoylglycerol
AI3-03482
SDA 16-001-00
rac-1-monolauroylglycerol
Glycerol alpha-monolaurate
Poem M 300
EC 205-526-6
EC 266-944-2
Glycerol monolaurate (GML) (VAN)
Glycerol .alpha.-dodecanoate
SCHEMBL16042
MLS004773952
2,3-Dihydroxypropyl laurate #
CHEMBL510533
CHEBI:75539
GLYCEROL 1-MONODODECANOATE
1-Lauroyl-rac-glycerol, >=99%
UNII-Y98611C087
1,2,3-Propanetriol 1-dodecanoate
MAG 12:0
NSC 4837
rac-2,3-dihydroxypropyl dodecanoate
EINECS 248-337-4
Tox21_112159
Tox21_300759
MFCD00037815
(.+/-.)-Glyceryl 1-monododecanoate
AKOS016005827
Dodecanoic acid,3-dihydroxypropyl ester
NCGC00164528-02
NCGC00164528-03
NCGC00164528-04
NCGC00254663-01
5-TRIFLUOROMETHYL-2-PYRIMIDINAMINE
AS-60593
NCI60_035284
SMR001254002
(+/-)-GLYCERYL 1-MONODODECANOATE
(.+/-.)-2,3-Dihydroxypropyl dodecanoate
HY-121620
FT-0625428
FT-0626744
FT-0774814
G0081
M 300
Y98611C087
(+/-)-2,3-DIHYDROXYPROPYL DODECANOATE
H10813
L-1475
A885218
Q2113676
GLYCEROL MONOSTEARATE (GMS)
DESCRIPTION:

1-monostearoylglycerol is a 1-monoglyceride that has stearoyl as the acyl group.
Glycerol monostearate (GMS) has a role as an algal metabolite and a Caenorhabditis elegans metabolite.
Glycerol monostearate, commonly known as GMS, is the glycerol ester of stearic acid .


CAS: 123-94-4
European Community (EC) Number: 250-705-4
IUPAC Name: 2,3-dihydroxypropyl octadecanoate
Molecular Formula: C21H42O4



Glycerol monostearate, commonly known as GMS, is a monoglyceride commonly used as an emulsifier in foods.
Glycerol monostearate takes the form of a white, odorless, and sweet-tasting flaky powder that is hygroscopic.
Chemically it is the glycerol ester of stearic acid.
Glycerol monostearate is also used as hydration powder in exercise formulas


Glycerol monostearate (GMS) is commonly used as an emulsifier in foods.
Glyceryl monostearate is a natural product found in Aristolochia cucurbitifolia, Lobelia longisepala, and other organisms with data available.


Glyceryl monostearate (GMS) is an effective emulsifier used in the baking industry available in the form of small beads, flakes, or powders.
In addition to emulsification, Glycerol monostearate (GMS) is a thickening agent and a stabilizer.
In baking, Glycerol monostearate (GMS) is used to improve dough quality and stabilize fat/protein emulsions.



Glyceryl monostearate (GMS) is a waxy ingredient that is obtained from coconuts, palm kernels, or olives.
Glyceryl monostearate (GMS) is usually pale yellow or white in color.
Glyceryl monostearate (GMS) is used in skin care and cosmetic products because of its great moisturizing properties.

Glyceryl monostearate (GMS) traps moisture on the skin and hair to prevent dehydration and damage.
Moreover, Glyceryl monostearate (GMS) also binds other ingredients together in a formulation.
Further, this ingredient is mildly comedogenic and may cause acne on some skin types.
The chemical formula of Glyceryl monostearate (GMS) is C21H42O4.



Glyceryl monostearate is a self emulsifying wax.
Glyceryl monostearate (GMS) is located in dozens of personal care products, including moisturizers, eye cream, sunscreen, makeup and hand creams.
Direct Chems provide Glyceryl monostearate (GMS) SE which is self emulsifying in pearl form and can be used as a viscosity enhancer adding emollient properties which makes skin softer and supple.


Glyceryl monostearate (GMS) also acts as a fast penetrating emollient which helps retain hydration, lubricate, condition and soften skin.
They slow loss of moisture so is ideal when adding to natural formulations.
The presence of Glyceryl monostearate (GMS) enables other ingredients in the formulation to continue functioning effectively in order to excel their beneficial properties by extending shelf life, preventing products from freezing and developing crusts on the surface.
One important factor is Glyceryl monostearate (GMS) allows oils to be added to products but decreases the greasiness so the final product is a smooth, creamy texture.


STRUCTURE, SYNTHESIS, AND OCCURRENCE OF GLYCEROL MONOSTEARATE (GMS):
Glyceryl monostearate (GMS) exists as three stereoisomers, the enantiomeric pair of 1-glycerol monostearate and 2-glycerol monostearate.
Typically these are encountered as a mixture as many of their properties are similar.

Commercial material used in foods is produced industrially by a glycerolysis reaction between triglycerides (from either vegetable or animal fats) and glycerol.
Glyceryl monostearate (GMS) occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase.
Glyceryl monostearate (GMS) is present at very low levels in certain seed oils




ORIGIN OF GLYCERYL MONOSTEARATE (GMS):
The first known emulsifier was egg yolk, often used to disperse liquid oil into an acidic aqueous phase.
Mono- and diglycerides were first synthesized in 1853 and were extensively used in shortening and margarine formulations by the 1930s.


COMPOSITION OF GLYCERYL MONOSTEARATE (GMS):
Glyceryl monostearate (GMS) is a non-ionic ester of glycerol and stearic acid.
Glyceryl monostearate (GMS) is soluble in ethanol at 122°F (50°C) but immiscible with water.
Glyceryl monostearate (GMS) often consists of a mixture of mono, di, and triesters of fatty acids occurring in food oils and fats.
They may contain small amounts of free fatty acids and glycerol.



COMMERCIAL PRODUCTION OF GLYCERYL MONOSTEARATE (GMS):
Glyceryl monostearate (GMS) is produced either through heating oils/fats with excess glycerol or by direct esterification of glycerol (of animal or plant sources) with stearic acid.
The proportion of monoester formed is dependent on the proportion of glycerol and reaction temperature range of 86-140°F (60-80°C).
Further purification is carried out by high vacuum distillation.



FUNCTION OF GLYCERYL MONOSTEARATE (GMS):
The ratio of hydrophilic to lipophilic moieties, called hydrophilic-lipophilic balance (HLB) is used in classifying emulsions.
HLB values range from 0-20 with lower values indicating dominant lipophilic character while higher values indicate hydrophilic character.
GMS has a HLB value of 3.8, making it lipophilic and suitable for uses in w/o emulsions, such as batters and doughs, dairy and other products.

Glyceryl monostearate (GMS) is used in a paste form, i.e. mixed with water and other ingredients to improve gel stability.
Glyceryl monostearate (GMS) is an unsaturated monoglyceride and offers better stability than other unsaturated monoglycerides, such as oleic acid.

Glyceryl monostearate (GMS) is used in the baking industry to:
Help in the formation and maintenance of uniform dispersions of immiscible solvents.
Stabilize emulsions via displacing proteins from oil, wax or solvent surfaces.


Improve bread texture, and retard staling due to its complexation with starch amylopectin
Improve aeration of doughs and batters.


APPLICATIONS OF GLYCERYL MONOSTEARATE (GMS):
Glyceryl monostearate (GMS) has been used in the following applications:
To improve the physical and rheological properties of the batter and thus better-quality cakes
In breads such as pain courant Français, Friss búzakenyér, naan and roti

In sponge cakes and pancakes for aeration.
Dairy products such as cream, whipped cream, ice cream, cream powder, imitation creams, etc.
Fruit/vegetable spreads, jams, jellies, marmalades



Application in plastics industry:

Glyceryl monostearate (GMS) is used As a lubricant, anti-static agent, non-toxic plasticizer, anti-aging in the production of polymers, plastics and packaging films.
Glyceryl monostearate (GMS) Can improve the flexibility, plasticity and anit-static properties.

Glyceryl monostearate (GMS) Is used e.g. in the manufacturing of of polypropylene-caps to provide a slip/lubricant effect in addition to anti-static effect.
Glyceryl monostearate (GMS) In agriculture plastic films as anti fogging agent.

Glyceryl monostearate (GMS) is used as a process aid in production of expanded polyethylene to improve gas
exchange.


PRODUCT BENEFITS OF GLYCERYL MONOSTEARATE (GMS):

Glyceryl monostearate (GMS) Reduces the friction during the extrusion process, giving a uniform cell size distribution and is improving the gas exchange.
Glyceryl monostearate (GMS) is compatible with anionic, cationic and non-ionic surfactants and has exceptional electrolyte tolerance.
Glyceryl monostearate (GMS) has effects of emulsification, dispersion, foaming, defoaming, starch antiaging.


Product dosing:
We strongly recommend testing of your own system under the actual conditions of processing and end-use prior to full scale testing.
Exact loading must be determined by composition of the specific polymer system.


Other applications:

Cosmetic uses, as a co-emulsifier of emulsions, to modify viscosity and improve stability.
Glyceryl monostearate (GMS) is used As an emulsifier in the production of foods, including ice cream, chewing gum, toffee, shortening, margarine, starch etc.

Anti-aging agent for starch.
Protective coating for hygroscopic powders.











USES OF GLYCERYL MONOSTEARATE (GMS):
Glyceryl monostearate (GMS) provides multiple benefits for the skin and hair.
This is why Glyceryl monostearate (GMS) is used in thousands of cosmetic, skin care, and hair care products such as skin cleansers, foundations, eyeliners, and shampoos.

Skin care:
Glyceryl monostearate (GMS) is a humectant that draws water to the top most layer of the skin and binds it there to provide intense hydration.
Glyceryl monostearate (GMS) also acts as a thickener to maintain the texture and spreadability of the products

Hair care:
Glyceryl monostearate (GMS) is used to bring luster and shine to the shafts by bringing back the lost water content.
This ingredient also has foaming properties that make it a great choice for products such as shampoos


Cosmetic products:
Glyceryl monostearate (GMS) acts as a surfactant.
Glyceryl monostearate (GMS) is a good preservative that keeps cosmetic products from going bad by increasing their shelf life.
Cosmetics with Glyceryl monostearate (GMS) do not dry easily and provide hydration to the skin


Glyceryl Monostearate (GMS) is a mixture of monoacylgcerols, mostly monosteroylglycerol, together with quantities of di-and triacylglycerols.
In the Ph.Eur, Glyceryl monostearate is distinguished into different grades, namely Type I, II and III depending on their fatty acid composition.
When supplied as an excipient, Glyceryl monostearate occurs as a hard, waxy mass or greasy powder, flakes or beads.


APPLICATIONS IN PHARMACEUTICAL FORMULATIONS OR TECHNOLOGY:
Glyceryl monostearate is principally used as an emollient, mild emulsifying agent, solubilizing agent, stabilizing agent, and tablet and capsule lubricant.
Owing to its lipid nature as well as the availability of many different grades, Glyceryl monostearate exhibits thickening, emulsifying and protective properties, making it a versatile excipient across multiple applications and dosage forms.

A summary of the different applications of Glyceryl monostearate in food, pharmaceutical, and cosmetic applications is outlined below:
• Formulation stabilizer (for water-in-oil emulsions containing polar and nonpolar ingredients)
• Dispersant for pigments in oils or solids in fats
• Solvent and co-solvent for phospholipids, such as lecithin
• Hot melt granulation excipient
• Matrix former for sustained-release tablets
• Lubricant for tablets
• Suppository base
• Hydrophobic agent in tablet coatings (prevents tablet sticking)

Incidences of polymorph formation when Glyceryl monostearate is used in product formulation are an important consideration.
Generally, the α-form tends to disperse easily and foams, rendering it useful as an emulsifying agent.
The β-form, being more stable, is suitable for use in sustained-release matrices.


Note that Glyceryl monostearate is not an efficient emulsifier.
Its usefulness resides in the fact that it is a useful emollient and co-emulsifier.
It is readily emulsified by common emulsifying agents and by the incorporation of other fatty materials into the formulation.

When added to creams, Glyceryl monostearate imparts to creams smoothness, and fineness, while improving the formulation stability.

About Glyceryl Monostearate – Self-emulsifying
Self-emulsifying Glyceryl monostearate is a grade of Glyceryl monostearate to which an emulsifying agent has been added.
A specification for self-emulsifying Glyceryl monostearate was previously included in the Ph.Eur (it still remains in the B.P).
This material is mainly used as an emulsifying agent for oils, fats, solvents, and waxes.
CHEMICAL CHARACTERISTICS
• Thickening agent
• Emulsifier
• Preservant
• Surfactant
• Moisturizer
• Dispersant
• Emollient
• Lubricant
• Anti-caking agent


AREAS OF APPLICATIONS
• Food manufacturing and beverage industry
• Textile industry
• Plastic industry
• Pharmaceuticals
• Cosmetics
• Personal care products



PRODUCT FEATURES
• Eco-friendly
• Water insoluble
• High Efficiency
• Non-toxic
• Cost competitive








SAFETY INFORMATION ABOUT GLYCEROL MONOSTEARATE (GMS):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product




CHEMICAL AND PHYSICAL PROPERTIES OF GLYCEROL MONOSTEARATE (GMS):
Molecular Weight
358.6 g/mol
XLogP3
7.4
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
20
Exact Mass
358.30830982 g/mol
Monoisotopic Mass
358.30830982 g/mol
Topological Polar Surface Area
66.8Ų
Heavy Atom Count
25
Formal Charge
0
Complexity
281
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Physical form, Solid, powder
Appearance, White or whitish, waxy solid
HLB Value, 3 (IMWITOR® 900 K)
Flash point, 240oC
Melting point, 55-60 oC
Boiling point, 238-240 oC
Relative density, 1.03 g/ml
Solubility, Insoluble in water
Melting point, 78-81 °C
Boiling point, 410.96°C (rough estimate)
Density, 0.9700
refractive index, 1.4400 (estimate)
storage temp., Sealed in dry,Store in freezer, under -20°C
solubility, Soluble in hot ethanol, ether, chloroform, hot acetone, mineral oil, and fixed oils. Practically insoluble in water, but may be dispersed in water with the aid of a small amount of soap or other surfactant.
form, Powder
color, Pure-white or cream-colored, wax-like solid
Odor, faint odor
Water Solubility, Soluble in hot organic solvents.Soluble in hot water. Slightly soluble in ethanol. Insoluble in aliphatic solvents.
Content of monoester (%):, Min. 95
Colour (Hazen):, Max. 190
Iodine value (gI2/100g):, Max. 3.0
Melting range (°C):, 60.0 - 70.0
Free acid (stearic acid) (%):, Max. 2.5
Free glycerol (%):, Max. 1.2
Water (%):, Max. 0.3
Arsenic (ppm):, Max. 1
Heavy metals (Pb, ppm):, Max. 5




SYNONYMS OF GLYCEROL MONOSTEARATE (GMS):
glyceryl monostearate
monostearin
Glyceryl monostearate
123-94-4
Monostearin
GLYCEROL MONOSTEARATE
31566-31-1
Glyceryl stearate
Tegin
1-Stearoyl-rac-glycerol
1-MONOSTEARIN
Glycerin 1-monostearate
Stearin, 1-mono-
Stearic acid 1-monoglyceride
2,3-dihydroxypropyl octadecanoate
Glycerol 1-monostearate
1-Glyceryl stearate
Glycerin 1-stearate
Sandin EU
1-Monostearoylglycerol
Octadecanoic acid, 2,3-dihydroxypropyl ester
Aldo MSD
Aldo MSLG
Glyceryl 1-monostearate
Stearoylglycerol
Glycerol 1-stearate
alpha-Monostearin
Tegin 55G
Emerest 2407
Aldo 33
Aldo 75
Glycerin monostearate
Arlacel 165
3-Stearoyloxy-1,2-propanediol
Cerasynt SD
Stearin, mono-
2,3-Dihydroxypropyl stearate
.alpha.-Monostearin
Monoglyceryl stearate
Glycerol alpha-monostearate
Cefatin
Dermagine
Monelgin
Sedetine
Admul
Orbon
Citomulgan M
Drewmulse V
Cerasynt S
Drewmulse TP
Tegin 515
Cerasynt SE
Cerasynt WM
Cyclochem GMS
Drumulse AA
Protachem GMS
Witconol MS
Witconol MST
FEMA No. 2527
Glyceryl stearates
Monostearate (glyceride)
Unimate GMS
Glyceryl monooctadecanoate
Ogeen M
Emcol CA
Emcol MSK
Hodag GMS
Ogeen GRB
Ogeen MAV
Aldo MS
Aldo HMS
Armostat 801
Kessco 40
Stearic monoglyceride
Abracol S.L.G.
Arlacel 161
Arlacel 169
Imwitor 191
Imwitor 900K
NSC 3875
11099-07-3
Atmul 67
Atmul 84
Starfol GMS 450
Starfol GMS 600
Starfol GMS 900
Cerasynt 1000-D
Emerest 2401
Aldo-28
Aldo-72
Atmos 150
Atmul 124
Estol 603
Ogeen 515
Tegin 503
Grocor 5500
Grocor 6000
Glycerol stearate, pure
Stearic acid alpha-monoglyceride
Cremophor gmsk
Glyceryl 1-octadecanoate
Cerasynt-sd
Lonzest gms
Cutina gms
Lipo GMS 410
Lipo GMS 450
Lipo GMS 600
glycerol stearate
1-MONOSTEAROYL-rac-GLYCEROL
Nikkol mgs-a
Glyceryl monopalmitostearate
USAF KE-7
1-octadecanoyl-rac-glycerol
EMUL P.7
EINECS 204-664-4
EINECS 245-121-1
UNII-230OU9XXE4
Stearic acid, monoester with glycerol
Glycerol .alpha.-monostearate
Glyceroli monostearas
Glycerol monostearate, purified
Imwitor 491
Sorbon mg-100
22610-63-5
Cithrol gms 0400
UNII-258491E1RZ
NSC3875
Stearic acid .alpha.-monoglyceride
(1)-2,3-Dihydroxypropyl stearate
MONOSTEARIN (L)
NSC-3875
1-Monooctadecanoylglycerol
EINECS 250-705-4
1,2,3-Propanetriol monooctadecanoate
Octadecanoic acid, ester with 1,2,3-propanetriol
GLYCERYL 1-STEARATE
1-O-Octadecanoyl-2n-glycerol
AI3-00966
MG(18:0/0:0/0:0)[rac]
230OU9XXE4
DTXSID7029160
CHEBI:75555
EC 250-705-4
GLYCERYL MONOSTEARATE 40-50
Octadecanoic acid, monoester with 1,2,3-propanetriol
258491E1RZ
1-Stearoyl-rac-glycerol (90per cent)
83138-62-9
NCGC00164529-01
(+/-)-2,3-DIHYDROXYPROPYL OCTADECANOATE
DTXCID909160
Octadecanoic acid, 2,3-dihydroxypropyl ester, (A+/-)-
MFCD00036186
Celinhol - A
CAS-123-94-4
Myvaplex 600
rac-Glycerol 1-stearate
C21H42O4
1-Monooctadecanoyl-rac-glycerol
Celinhol-A
Glyceryl monostearate [JAN:NF]
MG 18:0
(+/-)-2,3-Dihydroxypropyl octadecanoate; 1-Glyceryl stearate; 1-Monooctadecanoylglycerol; 1-Monostearin
Eastman 600
1-O-stearoylglycerol
1-octadecanoylglycerol
85666-92-8
rac-octadecanoylglycerol
glycerol 1-octadecanoate
rac-glyceryl monostearate
Glycerol .alpha.-sterate
rac-1-monostearoylglycerol
DSSTox_CID_9160
Monoglycerides, c16-18
(+-)-1-stearoylglycerol
SCHEMBL4488
(+-)-glyceryl monostearate
Geleol mono and diglycerides
DSSTox_RID_78757
DSSTox_GSID_29304
Glycerol monostearate (GMS)
(+-)-1-monostearoylglycerol
(+-)-1-octadecanoylglycerol
Glycerides, C16-18 mono-
Glycerol monostearate 40-55
GLYCERYL STEARATE (II)
CHEMBL255696
2,3-Dihydroxypropyl stearate #
DTXSID7027968
CHEBI:75557
1-Stearoyl-rac-glycerol (90%)
GLYCERYL MONOSTEARATE (II)
Glyceryl monostearate (JP17/NF)
1-Stearoyl-rac-glycerol, >=99%
MAG 18:0
EINECS 238-880-5
EINECS 293-208-8
Tox21_112160
Tox21_202573
Tox21_301104
LMGL01010003
rac-2,3-dihydroxypropyl octadecanoate
AKOS015901589
Tox21_112160_1
DB11250
(+-)-2,3-dihydroxypropyl octadecanoate
NCGC00164529-02
NCGC00164529-03
NCGC00164529-04
NCGC00255004-01
NCGC00260122-01
Octadecanoic acid,3-dihydroxypropyl ester
1,2,3-Propanetriol 1-octadecanoyl ester
BS-50505
CAS-11099-07-3
FT-0626740
FT-0626748
FT-0674656
G0085
Octadecanoic acid, 2.3-dihydroxypropyl ester
D01947
EC 293-208-8
F71433
S-7950
A890632
A903419
SR-01000944874
Q-201168
Q5572563
SR-01000944874-1
W-110285
()-2,3-Dihydroxypropyl octadecanoate; 1-Glyceryl stearate; 1-Monooctadecanoylglycerol; 1-Monostearin
342394-34-7
InChI=1/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H



GLYCEROL MONOSTEARATE (GMS)
Glycerol Monostearate (GMS) takes the form of a white, odorless, and sweet-tasting flaky powder that is hygroscopic.
Glycerol Monostearate, commonly known as GMS, is a monoglyceride commonly used as an emulsifier and thickener.
Glycerol Monostearate (GMS) is derived from glycerol (glycerin) and stearic acid, a saturated fatty acid.

CAS Number: 123-94-4
Molecular Formula: C21H42O4
Molecular Weight: 358.56
EINECS Number: 204-664-4

Glycerol Monostearate (GMS), also called monstearin or glyceryl stearate, is a hard, waxy mass, powder or flake ingredient, which is typically white.
Glycerol Monostearate (GMS) is derived from vegetable oils.
Glycerol Monostearate (GMS)e is often used as an emulsifier.

Glycerol Monostearate (GMS) is found in dozens of personal care products, such as moisturizers, eye cream, sunscreen, makeup, hand cream, and other products.
Glycerol Monostearate (GMS) is also used in foods as a thickener.
Glycerol Monostearate (GMS), also known as glyceryl monostearate or mono-and diglycerides of fatty acids (E471 when used as a food additive), is a chemical compound commonly used in various industries, including the food industry and cosmetics.

Glycerol Monostearate (GMS) appears as a white or slightly yellowish waxy solid or powder at room temperature.
Glycerol Monostearate (GMS) is a long chain molecule typically occurring in the body as a by-product of the breakdown of fats.

Glycerol Monostearate (GMS) is one of the panels of serum metabolic biomarkers for detecting and diagnosing cancer, especial ovarian cancer.
Glycerol Monostearate (GMS) is also used in the development of drug delivery vehicles such as nanoparticles and microemulsions.
Glycerol Monostearate (GMS) can also be used as an emulsifying agent, which allows the suspension of pharmaceuticals in a biodegradable form.

Glycerol Monostearate (GMS) is an effective emulsifier used in the baking industry available in the form of small beads, flakes, or powders.
In addition to emulsification, GMS is a thickening agent and a stabilizer.
Glycerol Monostearate (GMS), commonly known as GMS, is a monoglyceride commonly used as an emulsifier in foods.

Glycerol Monostearate (GMS) takes the form of a white, odorless, and sweet-tasting flaky powder that is hygroscopic.
Chemically it is the glycerol ester of stearic acid.
Glycerol Monostearate (GMS) is also used as hydration powder in exercise formulas.

Glycerol Monostearate (GMS) exists as three stereoisomers, the enantiomeric pair of 1-glycerol monostearate and 2-glycerol monostearate.
Typically these are encountered as a mixture as many of their properties are similar.
Glycerol Monostearate (GMS) is a fatty acid ester seen in food, cosmetics, and beauty products (hair and skin) for various uses, including as a: thickening agent, emulsifier, anti-sticking agent, dispersing agent, solvent, greasing agent, and perfume dilutant.

Glycerol Monostearate (GMS) is a Glyceryl Ester; Glyceryl Monostearate specifically occurs naturally in the body and fatty foods and is formed during the breakdown of fats in the body.
When applied topically, Glycerol Monostearate (GMS) constituent makes Glyceryl Stearate a fast-penetrating emollient that helps create a protective barrier on the skin's surface.
This helps retain hydration and slow the loss of moisture.

This reduced rate of water evaporation helps to lubricate, condition, soften, and smooth the skin.
Glycerol Monostearate (GMS)s protective properties extend to its antioxidant qualities, which help protect the skin against damage caused by free radicals.
When added to natural formulations, Glycerol Monostearate (GMS) has stabilizing effects on the final product, which means it helps the other ingredients in the formulation continue functioning effectively to exhibit their beneficial properties.

In this way, it helps to balance the product’s pH value and thereby prevents the product from becoming overly acidic or alkaline.
Glycerol Monostearate (GMS) also helps increase shelf life, prevents products from freezing or from developing crusts on their surfaces, and it helps lessen the greasy nature of some oils that may be added to cosmetics formulations.
In formulations that are oil-based, the thickening properties of Glycerol Monostearate (GMS) help to scale down the need for co-emulsifiers and, in emulsions with big water phases, Glyceryl Stearate can help develop liquid crystal phases as well as crystalline gel phases.

As an opacifier, Glycerol Monostearate (GMS) makes transparent or translucent preparations opaque, thus protecting them from or increasing their resistance to being penetrated by visible light.
This also helps to boost or balance the appearance of pigments and improve the final product's density for a luxuriously smooth and creamy texture.
Commercial material used in foods is produced industrially by a glycerolysis reaction between triglycerides (from either vegetable or animal fats) and glycerol.

Glycerol Monostearate (GMS) occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase.
Glycerol Monostearate (GMS) is present at very low levels in certain seed oils.
Glycerol Monostearate (GMS) is a non-ionic ester of glycerol and stearic acid.

Glycerol Monostearate (GMS) is soluble in ethanol at 122°F (50°C) but immiscible with water.
Glycerol Monostearate (GMS) often consists of a mixture of mono, di, and triesters of fatty acids occurring in food oils and fats.
They may contain small amounts of free fatty acids and glycerol.

Glycerol Monostearate (GMS) is produced either through heating oils/fats with excess glycerol or by direct esterification of glycerol (of animal or plant sources) with stearic acid.
The proportion of monoester formed is dependent on the proportion of glycerol and reaction temperature range of 86-140°F (60-80°C).
Further purification is carried out by high vacuum distillation.

Glycerol Monostearate (GMS) is a self emulsifying wax. It is located in dozens of personal care products, including moisturizers, eye cream, sunscreen, makeup and hand creams.
Direct Chems provide Glycerol Monostearate (GMS) SE which is self emulsifying in pearl form and can be used as a viscosity enhancer adding emollient properties which makes skin softer and supple.
Glycerol Monostearate (GMS), commonly known as GMS, is a monoglyceride commonly used as an emulsifier in foods.

Glycerol Monostearate (GMS) takes the form of a white, odorless, and sweet-tasting flaky powder that is hygroscopic.
Chemically Glycerol Monostearate (GMS) is the glycerol ester of stearic acid.
Glycerol Monostearate (GMS) exists as three stereoisomers, the enantiomeric pair of 1-glycerol monostearate and 2-glycerol monostearate.

Typically these are encountered as a mixture as many of their properties are similar.
Commercial material used in foods is produced industrially by a glycerolysis reaction between triglycerides (from either vegetable or animal fats) and glycerol.
Glycerol Monostearate (GMS) occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase.

Glycerol Monostearate (GMS) is present at very low levels in certain seed oils.
Glycerol Monostearate (GMS) is a food additive used as a thickening, emulsifying, anticaking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a
protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant.
Glycerol Monostearate (GMS) is also used in cosmetics and hair-care products.

Glycerol Monostearate (GMS) is largely used in baking preparations to add "body" to the food.
Glycerol Monostearate (GMS) is somewhat responsible for giving ice cream and whipped cream their smooth texture.
Glycerol Monostearate (GMS) is sometimes used as an antistaling agent in bread.

Glycerol Monostearate (GMS) can also be used as an additive in plastic, where GMS works as an antistatic and antifogging agent.
Glycerol Monostearate (GMS) also acts as a fast penetrating emollient which helps retain hydration, lubricate, condition and soften skin.
They slow loss of moisture so is ideal when adding to natural formulations.

The presence of Glycerol Monostearate (GMS) enables other ingredients in the formulation to continue functioning effectively in order to excel their beneficial properties by extending shelf life, preventing products from freezing and developing crusts on the surface.
One important factor is Glycerol Monostearate (GMS) allows oils to be added to products but decreases the greasiness so the final product is a smooth, creamy texture.
Glycerol Monostearate (GMS), commonly known as GMS, is an organic molecule used as an emulsifier.

Glycerol Monostearate (GMS) is a white, odorless, and sweet-tasting flaky powder that is hygroscopic.
Glycerol Monostearate (GMS) is a glycerol ester of stearic acid.
Glycerol Monostearate (GMS) occurs naturally in the body as a by-product of the breakdown of fats, and is also found in fatty foods.

Glycerol Monostearate (GMS) is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant.
Glycerol Monostearate (GMS) is also used in cosmetics and hair care products.
Glycerol Monostearate (GMS) is often used as an emulsifier, helping to combine ingredients that would normally not mix well, such as oil and water.

Glycerol Monostearate (GMS)'s used in products like salad dressings, mayonnaise, and creamy sauces to prevent separation and improve texture.
In baked goods like bread, cakes, and pastries, Glycerol Monostearate (GMS) can improve the texture, crumb structure, and moisture retention.
Glycerol Monostearate (GMS) helps create a softer and more tender texture in these products.

Glycerol Monostearate (GMS) can stabilize foams and whipped products, enhancing the volume and stability of products like whipped cream, meringues, and ice creams.
Glycerol Monostearate (GMS)can be used to prevent the formation of ice crystals in ice cream and frozen desserts, resulting in a smoother and creamier texture.
Glycerol Monostearate (GMS) can be used in reduced-fat or low-fat products to mimic some of the texture and mouthfeel lost when fat is reduced.

Glycerol Monostearate (GMS) can improve the quality of cake mixes by helping to disperse ingredients evenly and enhance the overall texture.
Glycerol Monostearate (GMS) can be used to stabilize and emulsify flavor oils in beverages, helping to create a consistent flavor experience.
Glycerol Monostearate (GMS) can be used in some candies and confections to improve texture, prevent crystallization, and provide a smoother mouthfeel.

Glycerol Monostearate (GMS) is a white or yellowish white, hard waxy mass or unctuous powder or flakes; odourless or slight, agreeable, fatty odour.
Glycerol Monostearate (GMS) should be kept in a tightly closed container, protected from light.
Glycerol Monostearate (GMS) may contain a suitable antioxidant.

Glycerol Monostearate (GMS) is a mixture of mono-, di- and triglycerides of stearic and palmitic acids.
Glycerol Monostearate (GMS) contains not less than the equivalent of 35.0% of monoglycerides, calculated as C20H40O4, and not morethan the equivalent of 6.0% of free glycerol.
Fatty acid esters, such as Glycerol Monostearate (GMS) and more particularly ‘high-mono GMS’ containing more than 95% monoester; GMS is in accordance with most food contact regulations.

Glycerol Monostearate (GMS) is a high-quality and high-efficiency edible emulsifier, which has the functions of emulsification, dispersion, stabilization, foaming, defoaming and starch anti-aging.
Glycerol Monostearate (GMS) is widely used the the manufacturing of ice cream, peanut butter, cake gel, bread and cakes.
Glycerol Monostearate (GMS), commonly referred to as GMS, is an odorless white flake with a sweet flavor profile.

Glycerol Monostearate (GMS) is produced by combining glycerin and stearic acid and has a minimum of 40% Monoglyceride content.
The primary application for Glycerol Monostearate (GMS) is to act as an emulsifier in foods such as breads, cakes, biscuits, margarine, shortening, peanut butter, among a wide range of other consumable goods that require an overall improvement in volume, texture, and consistency.
Glycerol Monostearate (GMS) is often added to food and beverage formulations to thicken the composition of a recipe in addition to preventing the product from drying out.

In addition to food and beverage manufacturing, Glycerol Monostearate (GMS) finds use for industrial applications.
Glycerol Monostearate (GMS) is an internationally recognized non-toxic, harmless and safe food ingredient used in various food processing.
In addition, Glycerol Monostearate (GMS) has a wider range of applications in the plastics industry, mainly used as mold release agents, plasticizers, antistatic additives, anti-shrinkage agents for plastic foam products, and internal lubricants in compound lead salt stabilizers.

In the production of PVC pipes and profiles, Glycerol Monostearate (GMS) is used as an internal lubricant instead of stearic acid, which reduces the surface precipitation of PVC products and acts as a plasticizer.
In recent years, Glycerol Monostearate (GMS) has been well used in the PVC pipe and profile industry.

Melting point: 78-81 °C
Boiling point: 476.9±25.0 °C(Predicted)
Density: 0.9678 g/cm3
FEMA: 2527 | GLYCERYL MONOSTEARATE
storage temp.: -20°C
solubility: Chloroform (Slightly)
form: Solid
pka: 13.16±0.20(Predicted)
color: White to Off-White
Odor: at 100.00 %. mild fatty waxy
Odor Type: fatty
JECFA Number: 918
Merck: 4489
BRN: 1728685
Hydrophilic-Lipophilic Balance (HLB): 5.5
InChIKey: VBICKXHEKHSIBG-UHFFFAOYSA-N
LogP: 7.23

Glycerol Monostearate (GMS) is widely used as an emulsifying agent in the food industry.
Glycerol Monostearate (GMS) helps mix ingredients that would otherwise separate, such as oil and water.
This property is particularly valuable in the production of various food products, including ice cream, salad dressings, and baked goods, where it can improve texture and stability.

Glycerol Monostearate (GMS) can act as a stabilizer, helping to prevent the crystallization of fats and oils in certain products.
This is especially important in frozen desserts like ice cream, where it enhances creaminess and prevents the formation of ice crystals.
Glycerol Monostearate (GMS) can also function as a thickening agent in food products, giving them a desirable texture or mouthfeel.

Glycerol Monostearate (GMS) is often used in cake batters, pudding, and other desserts to improve consistency.
Glycerol Monostearate (GMS) is utilized in cosmetics and personal care products, such as creams, lotions, and cosmetics, as an emulsifier, thickener, and moisturizing agent.
Glycerol Monostearate (GMS) helps create stable and creamy formulations.

Glycerol Monostearate (GMS) can serve as a binding agent in tablet production, helping to hold the active ingredients together and improve the tablet's disintegration properties.
Glycerol Monostearate (GMS) can be used as a processing aid in the production of plastics and rubber, where it can act as a lubricant, release agent, and antistatic agent.
Glycerol Monostearate (GMS) can be used as a softening agent for textiles and fabrics, improving their texture and feel.

Glycerol Monostearate (GMS) may be incorporated into paint and coating formulations to modify their rheological properties and improve their spreadability.
Glycerol Monostearate (GMS) is used in candle manufacturing as a wax additive to improve the candle's burn time and texture.
Glyceryl Monostearate (GMS) is a mixture of monoacylgcerols, mostly monosteroylglycerol, together with quantities of di-and triacylglycerols.

In the Ph.Eur, Glycerol Monostearate (GMS) is distinguished into different grades, namely Type I, II and III depending on their fatty acid composition.
When supplied as an excipient, Glycerol Monostearate (GMS) occurs as a hard, waxy mass or greasy powder, flakes or beads.
Glycerol Monostearate (GMS) is used in a paste form, i.e. mixed with water and other ingredients to improve gel stability.

Glycerol Monostearate (GMS) is an unsaturated monoglyceride and offers better stability than other unsaturated monoglycerides, such as oleic acid.
Glycerol Monostearate (GMS) is a single-tailed lipidic monoglyceride commonly used as a nontoxic food additive.
In this study, we have investigated Glycerol Monostearate (GMS), specifically its self-assembling properties and subsequent application in drug delivery.

Results from in silico modeling, corroborated by complementary small-angle neutron scattering, demonstrated vesicle formation; associated phase transitions were analyzed using differential scanning calorimetry; dynamic light scattering revealed particle size alterations that occurred in the transition region.
Spherical morphology of unilamellar vesicles was visualized using transmission electron microscopy imaging.
Further, hydrophilic and hydrophobic drug loading in GMS vesicles and their amenability to surface modification for hepatic targeting have, in this study, been both predicted through molecular simulation study and demonstrated experimentally.

The influence of hepatotropic ligands on the stability of drug-loaded Glycerol Monostearate (GMS) vesicles vis-à-vis cholesterol has also been investigated; the resulting GMS based drug delivery vehicle, its properties enhanced through surface decoration, is envisaged to achieve targeted delivery of its payload to hepatocytes.
Glycerol Monostearate (GMS) is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant.

Glycerol Monostearate (GMS) is also used in cosmetics and hair care products.
Glycerol Monostearate (GMS) objective of the present investigation was to study the spontaneous self-assembling behavior of stearic acid in the presence of its monoglyceride and to evaluate its potential to be used as drug delivery vehicle.
Glycerol Monostearate (GMS) interesting feature of this system lies in spontaneous formation of vesicles on hydration of molten mixture of stearic acid (SA) and glyceryl monostearate (GMS) without using any solvent.

Glycerol Monostearate (GMS) 1H NMR spectrum of a sample was devoid of signals from fatty acid side chain protons, suggesting that upon interaction between SA and GMS, it adopts an orientation in which fatty acid side chains exists in hydrophobic domains separated from hydrophilic headgroup.
Glycerol Monostearate (GMS) is composed of naturally occuring lipid ingredients glycerol and stearic acid.
Fragrance ingredient, skin-conditioning agent - emollient, surfactant - emulsifying agent, emollient, and emulsifying Glycerol Monostearate (GMS), C21H42O4, also known as monostearin, is a mixture of variable proportions of glyceryl monostearate, glyceryl monopalmitate , and glyceryl esters of fatty acids present in commercial stearic acid.

Glyceryl Stearate, also referred to as Glycerol Monostearate (GMS), is a fatty acid derived from vegetable oil, Soy Oil, or Palm Kernel Oil; however, it is also naturally occurring in the human body.
This wax-like substance appears white or cream in color and is produced when Glycerol Monostearate (GMS) undergo esterification.
Traditionally, it is used in formulations for its emulsifying properties.

Glycerol Monostearate (GMS) also contains Sodium Stearate and/or Potassium Stearate.
The “SE” of Glyceryl Stearate SE stands for “Self-Emulsifying,” as it is a self-emulsifying form of Glycerol Monostearate (GMS).
While the names Glycerol Monostearate (GMS) and mono- and diglycerides are used for a variety of esters of long-chain fatty acids, the esters fall into two distinct grades.

40–55 percent monoglycerides The PhEur 6.0 describes Glycerol Monostearate (GMS) 40–55 as a mixture of monoacylglycerols, mostly monostearoylglycerol, together with quantities of di- and triacylglycerols.
Glycerol Monostearate (GMS) contains 40–55% of monoacylglycerols, 30–45% of diacylglycerols, and 5–15% of triacylglycerols.
This PhEur grade corresponds to mono- and di-glycerides USP– NF, which has similar specifications (not less than 40% monoglycerides).

90 percent monoglycerides The USP32–NF27 describes Glycerol Monostearate (GMS) as consisting of not less than 90% of monoglycerides of saturated fatty acids, chiefly glyceryl monostearate (C21H42O4) and glyceryl monopalmitate (C19H38O4).
The commercial products are mixtures of variable proportions of Glycerol Monostearate (GMS) and glyceryl monopalmitate.
Glycerol Monostearate (GMS) is a white to cream-colored, wax-like solid in the form of beads, flakes, or powder.

Glycerol Monostearate (GMS) is waxy to the touch and has a slight fatty odor and taste.
Glycerol Monostearate (GMS) is an emulsifier that helps form neutral, stable emulsions.
Glycerol Monostearate (GMS) is also a solvent, humectant, and consistency regulator in water-in-oil and oil-in-water formulations.

In addition, Glycerol Monostearate (GMS) can be used as a skin lubricant and imparts a pleasant skin feel.
Glycerol Monostearate (GMS) is a mixture of mono-, di-, and triglycerides of palmitic and stearic acids, and is made from glycerin and stearic fatty acids.
Derived for cosmetic use from palm kernel or soy oil, it is also found in the human body.

Glycerol Monostearate (GMS) is very mild with a low skin-irritation profile; however, a slight risk of irritation exists if products contain poor quality glyceryl stearate.
Glycerol Monostearate (GMS) is also known as monostearin, is a mixture of variable proportions of glyceryl monostearate, glyceryl monopalmitate, and glyceryl esters of fatty acids present in commercial stearic acid.
Glycerol Monostearate (GMS) prepared by glycerolysis of certain fats or oils that are derived from edible sources or by esterification, with glycerin, of stearic acid that is derived from edible sources.

Glycerol Monostearate (GMS) and Glyceryl StearatejSE are the esterification products of glycerine and stearic acid.
Glycerol Monostearate (GMS) contains excess stearic acid reacted with potassium hydroxide to produce a self-emulsifying product.
Both Glycerol Monostearate (GMS) and Glyceryl Stearate/SE are white to creamcolored wax-like solids.

Either ingredient may contain mono-, di-, and triglyceride impurities and fatty acid impurities.
Glycerol Monostearate (GMS) and Glyceryl StearateISE are widely used in cosmetic formulations as emollients, auxiliary emulsifiers, viscosifiers, stabilizers, bases, and surfactants.
Glycerol Monostearate (GMS) is used in more than 1200 cosmetic formulations at concentrations of rO.1-50%; Glyceryl Stearate/ SE is used in over 200 cosmetic products at concentrations of z 0.1-50%.
Glycerol Monostearate (GMS) is also widely used in foods as a surfactant, emulsifier, and thickener.

Glycerol Monostearate (GMS) is an antistalant and dough conditioner in breads and is also used in pharmaceutical bases.
Glycerol Monostearate (GMS) has been granted regulatory status as GRAS ingredient, an indirect food additive, a direct food additive, and as an OTC substance.
In acute oral toxicity studies in rats, Glycerol Monostearate (GMS) and Glyceryl Stearate/SE were nontoxic or mildly toxic.

In chronic studies, 15-25% Glycerol Monostearate (GMS) in the diet of rats for three consecutive generations had no adverse effects.
Rats fed a diet containing 25% Glycerol Monostearate (GMS) for two years developed renal calcifications.
Glycerol Monostearate (GMS) and Glyceryl Stearate/SE at concentrations of up to 100% were reported to be mildly irritating or nonirritating to the skin of rabbits.

In subchronic and chronic dermal toxicity tests, 4-5% Glycerol Monostearate (GMS) was nontoxic to rabbits but did cause moderate irritation (slight to moderate erythema, edema, atonia, desquamation, and/or fissuring).
In seven guinea pig sensitization studies, it was concluded that neither Glycerol Monostearate (GMS) nor Glyceryl Stearate/SE was capable of inducing sensitization.
In primary eye irritation studies, Glycerol Monostearate (GMS) and Glyceryl Stearate/SE at concentrations up to 100% were mildly irritating or nonirritating when instilled in the eyes of rabbits.

Glycerol Monostearate (GMS), fed to mice in doses of 50-100 mg/day or 1.5% in the diet until they died, did not induce significant brain or gastric tumor formation, respectively.
Five percent Glycerol Monostearate (GMS) did not promote the carcinogenicity of DMBA in mouse skin.
Single and Repeated Insult Patch Tests used to evaluate human skin irritation and sensitization potential of Glycerol Monostearate (GMS) and Glyceryl Stearate/SE showed both ingredients to be nonse'3ritizing and nonirritating.

Products containing 2% Glycerol Monostearate (GMS) were nonphototoxic anu ionphotoallergic.
Worker experience shows that Glycerol Monostearate (GMS) and Glyceryl Stearate/SE are nonirritating to human skin.
Glyceryl monostearate (GMS), a nonionic amphiphilic monoglyceride of glycerol and stearic acid is widely used as emulsifier in food, cosmetic, pharmaceutical and textile industry.

Glycerol Monostearate (GMS) exists as three stereoisomers, the enantiomeric pair of 1-glycerol monostearate and 2-glycerol monostearate.
Typically these are encountered as a mixture as many of their properties are similar.
Commercial material used in foods is produced industrially by a glycerolysis reaction between triglycerides (from either vegetable or animal fats) and glycerol.

Uses
Glycerol Monostearate (GMS) is self-emulsifying glyceryl stearate.
Glycerol Monostearate (GMS) provides a stable, uniform oil-in-water emulsion.
Glycerol Monostearate (GMS) is used in the development of drug delivery vehicles such as nanoparticles and microemulsions.

Glycerol Monostearate (GMS) is a food additive used as a thickening, emulsifying, anticaking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant.
Glycerol Monostearate (GMS) is also used in cosmetics and hair-care products.
In industry, Glycerol Monostearate (GMS) can be used as an emulsifier.

Glycerol Monostearate (GMS) also occurs naturally in the body as a fat metabolite, and is present in foods with high fat content.
Glycerol Monostearate (GMS) pharmaceuticals, Glycerin monostearate is used as a protective coating for hygroscopic powders, and a solidifier and control release agen.
Glycerol Monostearate (GMS) is widely used in the food industry as an emulsifying agent to create stable mixtures of ingredients that would otherwise separate, such as oil and water.

Glycerol Monostearate (GMS) is commonly found in salad dressings, sauces, and mayonnaise.
In frozen desserts like ice cream, Glycerol Monostearate (GMS) helps prevent the crystallization of fats, improving the texture and preventing the formation of ice crystals.
Glycerol Monostearate (GMS) can thicken food products, providing a desirable texture in items like puddings, custards, and soups.

Glycerol Monostearate (GMS) is used in baked goods like bread, cakes, and cookies to improve texture, moisture retention, and shelf life.
Glycerol Monostearate (GMS) is added to dairy products such as yogurt and cream to enhance creaminess and consistency.
Glycerol Monostearate (GMS) can be found in chocolates and candies to prevent fat bloom and ensure a smooth texture.

Glycerol Monostearate (GMS) commonly known as GMS, is an organic molecule used as an emulsifier.
Glycerol Monostearate (GMS) is a colorless, odorless, and sweet-tasting flaky powder that is hygroscopic.
Glycerol Monostearate (GMS) is a glycerol ester of stearic acid.

Glycerol Monostearate (GMS) occurs naturally in the body as a by-product of the breakdown of fats, and is also found in fatty foods.
Glycerol Monostearate (GMS) is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent, an emulsifying agent for oils, waxes and solvents, a
protective coating for hygroscopic powders, a solidifier and control release agent in pharmaceuticals, and a resin lubricant.
Glycerol Monostearate (GMS) is also used in cosmetics and hair care products.GMS is largely used in baking preparations to add "body" to the food.

Glycerol Monostearate (GMS) is responsible for giving ice cream and whipped cream its smooth texture.
Glycerol Monostearate (GMS) can, therefore, be used in all plastics employed for food packaging fatty amine polyglycol ethers (e.g., cocoamine + 2 EO) fatty acid diethanolamides (e.g., coconut fatty acid diethanolamide) fatty alcohol polyglycol ethers (can be used as internal antistats and viscosity modifiers in PVC plastisols or as external antistats in mold release formulations for green tires)

Glycerol Monostearate (GMS) is used as an emulsifier, resin lubricant, opacifier, emollient, bodying agent in a variety of cosmetic formulations for skincare and haircare.
Glycerol Monostearate (GMS) is also used as a thickening, anti-caking and preservative agent.
Glycerol Monostearate (GMS) is also useful for preventing ice creams from drying out or being too sweet.

Glycerol Monostearate (GMS) is further used as a foaming agent for the foam-mat drying of papaya.
Glycerol Monostearate (GMS) is also used as an anti-staling agent in bread.
Glycerol Monostearate (GMS) is used in cosmetics and personal care products, including creams, lotions, and makeup, to create stable emulsions and improve product consistency.

Glycerol Monostearate (GMS) is used as both emulsifier and stabilizer in the food industry. It is commercially available in powder or bead forms.
Glycerol Monostearate (GMS) is a food additive with a distinctive odor, white or sometimes beige in color and known in the food industry with the food code e 471.
Glycerol Monostearate (GMS) is a highly effective emulsifier in emulsifying the oil-water phase.

Glycerol Monostearate (GMS) is also effective in extending the stratification and shelf life of food products.
Glycerol Monostearate (GMS) is especially used in the bread and bakery products and pastry industry, in the oil industry.
Apart from the food industry, Glycerol Monostearate (GMS) finds use in the cosmetics, detergent, plastic and pharmaceutical industries.

Glycerol Monostearate (GMS), which is involved in the formulations of ice cream, starchy products, dairy products, chewing gum, chocolate and other food products.
Glycerol Monostearate (GMS) is used as a softener in textile products and as a lubricant in plastic products.
Glycerol Monostearate (GMS) is used as an emulsifier in ice cream, GMS prevents the development of coarse ice crystals and gives a smooth texture.

Glycerol Monostearate (GMS), which ensures the formation of stable emulsions that do not break down during freezing, improves the shelf life by keeping the ice cream firm and dry without hardening.
Glycerol Monostearate (GMS) for bakery products such as bread and cake; It causes soft, moist, good pore structure in the product, gives white shine and volume to the products, retains moisture, delays spongy structure and staleness, and increases the shelf life of the product.
With the use of Glycerol Monostearate (GMS), the amount of egg yolk used in the products decreases and thus reduces the cost.

In chocolate products, Glycerol Monostearate (GMS) provides a good oil dispersion even at high temperatures, reduces stickiness and separation during production and storage, improves texture and consistency, reduces sugar crystallization, reduces the loss of flowering and product-specific shine, prevents products such as caramel and nougat from precipitation on the tooth, It provides better dispersion and stabilization and acts as a plasticizer in chewing gums.
In margarine products, on the other hand, it reduces the tension between oil and water interfaces, which leads to the formation of stable emulsions.

When used with soy lecithin, the solubility of Glycerol Monostearate (GMS) is increased.
Glycerol Monostearate (GMS), which leads to a better mouthfeel in the product and increases its spreadability, emulsifies the water in margarine and stabilizes the water in the oil.
Glycerol Monostearate (GMS) is widely used in cosmetics.
Glycerol Monostearate (GMS) is an emulsifying and solubilizing ingredient, dispersing agent, emollient, formula stabilizer, and surface-action agent.
Employed in baby creams, face masks, foundation, and hand lotions, it is often derived from hydrogenated soybean oil.

Glycerol Monostearate (GMS) has little or no G toxicity.
Glycerol Monostearate (GMS) is prepared by the reaction of glycerin with triglycerides from animal or vegetable sources, producing a mixture of monoglycerides and diglycerides.
The diglycerides may be further reacted to produce the 90% monoglyceride grade.

Another process involves reaction of Glycerol Monostearate (GMS) with stearoyl chloride.
The starting materials are not pure substances and therefore the products obtained from the processes contain a mixture of esters, including palmitate and oleate.
Consequently, the composition, and therefore the physical properties, of Glycerol Monostearate (GMS) may vary considerably depending on the manufacturer.

The many varieties of Glycerol Monostearate (GMS) are used as nonionic emulsifiers, stabilizers, emollients, and plasticizers in a variety of food, pharmaceutical, and cosmetic applications.
Glycerol Monostearate (GMS) acts as an effective stabilizer, that is, as a mutual solvent for polar and nonpolar compounds that may form water-in-oil or oil-in-water emulsions.
Glycerol Monostearate (GMS) has moisturizing properties, making it suitable for skincare products, lip balms, and hair conditioners.

Glycerol Monostearate (GMS) can thicken formulations, providing a luxurious and creamy texture in products like body lotions and shower gels.
In pharmaceutical tablets and capsules, Glycerol Monostearate (GMS) serves as a binding agent to hold the active ingredients together and improve tablet disintegration properties.
In the manufacturing of plastics and rubber, Glycerol Monostearate (GMS) acts as a processing aid, lubricant, and antistatic agent.

Glycerol Monostearate (GMS) is used in the textile industry as a softening agent for fabrics, enhancing their texture and feel.
Glycerol Monostearate (GMS) can be incorporated into paint and coating formulations to modify rheological properties and improve spreadability.
Glycerol Monostearate (GMS) is used in candle production as a wax additive to improve burn time and candle texture.

Glycerol Monostearate (GMS) is used as a binding agent in tablet production, helping to hold the active ingredients together and improve tablet disintegration properties.
Glycerol Monostearate (GMS) is largely used in baking preparations to add "body" to the food.
Glycerol Monostearate (GMS) is somewhat responsible for giving ice cream and whipped cream their smooth texture.

Glycerol Monostearate (GMS) is sometimes used as an antistaling agent in bread.
Glycerol Monostearate (GMS) can also be used as an additive in plastic, where Glycerol Monostearate (GMS) works as an antistatic and antifogging agent.
Glycerol Monostearate (GMS) can be used in tablet coating formulations to provide a smooth and consistent coating on pharmaceutical tablets, making them easier to swallow and improving their appearance.

Glycerol Monostearate (GMS) is found in some toothpaste formulations as a thickening and stabilizing agent to provide the desired texture and consistency.
Glycerol Monostearate (GMS) is used in the pet food industry as an emulsifier and stabilizer in various pet food products, including wet and dry pet foods.
Glycerol Monostearate (GMS) can be employed in the paper industry as a paper coating additive to improve printability, reduce dusting, and enhance the paper's surface properties.

Glycerol Monostearate (GMS) can be used as a slip agent to reduce friction between layers of film and improve the film's handling and processing characteristics.
Glycerol Monostearate (GMS) may be added to adhesive formulations to improve their tackiness and adhesion properties, making them more effective in bonding various materials.
Glycerol Monostearate (GMS) can serve as a base material for suppositories in pharmaceutical applications, helping to solidify and shape the suppository for rectal administration.

Glycerol Monostearate (GMS) can be used as a component of metalworking fluids to provide lubrication and cooling properties in machining processes.
Glycerol Monostearate (GMS) may be used as a component in lubricants to reduce friction and wear in machinery.

Glycerol Monostearate (GMS) is added to shoe polish formulations to enhance the shine and water resistance of leather shoes.
Glycerol Monostearate (GMS) is used in some pyrotechnic compositions to control the burning rate of fireworks and produce specific effects.

Safety Profile:
Concentrated or prolonged contact with Glycerol Monostearate (GMS) may cause skin and eye irritation in some individuals.
Glycerol Monostearate (GMS) is advisable to wear appropriate personal protective equipment (PPE), such as gloves and safety goggles, when handling Glycerol Monostearate (GMS) in its concentrated form.

Glycerol Monostearate (GMS) powder or dust can lead to respiratory irritation.
Adequate ventilation is important when working with powdered GMS.
Although rare, some individuals may have allergies or sensitivities to Glycerol Monostearate (GMS).

Allergic reactions could include skin rashes or other symptoms.
Glycerol Monostearate (GMS) itself is not flammable, but it can release flammable gases (siloxanes) if subjected to high temperatures or open flames.

Therefore, it should be stored away from heat sources and open flames.
To minimize hazards, follow safe handling practices, such as wearing appropriate PPE, avoiding contact with eyes and skin, and taking measures to prevent inhalation of dust or powder during handling.

Synonyms:
Glyceryl monostearate
123-94-4
Monostearin
GLYCEROL MONOSTEARATE
31566-31-1
Glyceryl stearate
Tegin
1-Stearoyl-rac-glycerol
1-MONOSTEARIN
Glycerin 1-monostearate
Stearin, 1-mono-
Stearic acid 1-monoglyceride
2,3-dihydroxypropyl octadecanoate
Glycerol 1-monostearate
1-Glyceryl stearate
Glycerin 1-stearate
Sandin EU
1-Monostearoylglycerol
Octadecanoic acid, 2,3-dihydroxypropyl ester
Aldo MSD
Aldo MSLG
Glyceryl 1-monostearate
Stearoylglycerol
Glycerol 1-stearate
alpha-Monostearin
Tegin 55G
Emerest 2407
Aldo 33
Aldo 75
Arlacel 165
3-Stearoyloxy-1,2-propanediol
Cerasynt SD
Stearin, mono-
2,3-Dihydroxypropyl stearate
.alpha.-Monostearin
Monoglyceryl stearate
Glycerol alpha-monostearate
Cefatin
Dermagine
Monelgin
Sedetine
Admul
Orbon
Citomulgan M
Drewmulse V
Cerasynt S
Drewmulse TP
Tegin 515
Cerasynt SE
Cerasynt WM
Cyclochem GMS
Drumulse AA
Protachem GMS
Witconol MS
Witconol MST
FEMA No. 2527
Glyceryl stearates
Monostearate (glyceride)
Unimate GMS
Glyceryl monooctadecanoate
Ogeen M
Emcol CA
Emcol MSK
Hodag GMS
Ogeen GRB
Ogeen MAV
Aldo MS
Aldo HMS
Armostat 801
Kessco 40
Stearic monoglyceride
Abracol S.L.G.
Arlacel 161
Arlacel 169
Imwitor 191
Imwitor 900K
NSC 3875
11099-07-3
Atmul 67
Atmul 84
Starfol GMS 450
Starfol GMS 600
Starfol GMS 900
Cerasynt 1000-D
Emerest 2401
Aldo-28
Aldo-72
Atmos 150
Atmul 124
Estol 603
Ogeen 515
Tegin 503
Grocor 5500
Grocor 6000
Glycerol stearate, pure
Stearic acid alpha-monoglyceride
Cremophor gmsk
Glyceryl 1-octadecanoate
Cerasynt-sd
Lonzest gms
Cutina gms
Lipo GMS 410
Lipo GMS 450
Lipo GMS 600
glycerol stearate
1-MONOSTEAROYL-rac-GLYCEROL
Nikkol mgs-a
Glyceryl monopalmitostearate
USAF KE-7
1-octadecanoyl-rac-glycerol
EMUL P.7
EINECS 204-664-4
EINECS 245-121-1
UNII-230OU9XXE4
Stearic acid, monoester with glycerol
Glycerol .alpha.-monostearate
Glyceroli monostearas
Glycerol monostearate, purified
Imwitor 491
Sorbon mg-100
22610-63-5
Cithrol gms 0400
UNII-258491E1RZ
NSC3875
Stearic acid .alpha.-monoglyceride
(1)-2,3-Dihydroxypropyl stearate
MONOSTEARIN (L)
C21H42O4
NSC-3875
1-Monooctadecanoylglycerol
EINECS 250-705-4
1,2,3-Propanetriol monooctadecanoate
Octadecanoic acid, ester with 1,2,3-propanetriol
GLYCERYL 1-STEARATE
1-O-Octadecanoyl-2n-glycerol
AI3-00966
MG(18:0/0:0/0:0)[rac]
230OU9XXE4
DTXSID7029160
CHEBI:75555
EC 250-705-4
GLYCERYL MONOSTEARATE 40-50
Octadecanoic acid, monoester with 1,2,3-propanetriol
258491E1RZ
1-Stearoyl-rac-glycerol (90per cent)
83138-62-9
NCGC00164529-01
(+/-)-2,3-DIHYDROXYPROPYL OCTADECANOATE
DTXCID909160
Octadecanoic acid, 2,3-dihydroxypropyl ester, (A+/-)-
MFCD00036186
Celinhol - A
CAS-123-94-4
GMS
Myvaplex 600
rac-Glycerol 1-stearate
1-Monooctadecanoyl-rac-glycerol
Celinhol-A
Glyceryl monostearate [JAN:NF]
MG 18:0
(+/-)-2,3-Dihydroxypropyl octadecanoate; 1-Glyceryl stearate; 1-Monooctadecanoylglycerol; 1-Monostearin
Eastman 600
1-O-stearoylglycerol
1-octadecanoylglycerol
85666-92-8
rac-octadecanoylglycerol
glycerol 1-octadecanoate
rac-glyceryl monostearate
Glycerol .alpha.-sterate
rac-1-monostearoylglycerol
DSSTox_CID_9160
Monoglycerides, c16-18
(+-)-1-stearoylglycerol
SCHEMBL4488
(+-)-glyceryl monostearate
Geleol mono and diglycerides
DSSTox_RID_78757
DSSTox_GSID_29304
Glycerol monostearate (GMS)
(+-)-1-monostearoylglycerol
(+-)-1-octadecanoylglycerol
Glycerides, C16-18 mono-
Glycerol monostearate 40-55
GLYCERYL STEARATE (II)
CHEMBL255696
2,3-Dihydroxypropyl stearate #
DTXSID7027968
CHEBI:75557
1-Stearoyl-rac-glycerol (90%)
GLYCERYL MONOSTEARATE (II)
Glyceryl monostearate (JP17/NF)
1-Stearoyl-rac-glycerol, >=99%
MAG 18:0
EINECS 238-880-5
EINECS 293-208-8
Tox21_112160
Tox21_202573
Tox21_301104
LMGL01010003
rac-2,3-dihydroxypropyl octadecanoate
AKOS015901589
Tox21_112160_1
DB11250
(+-)-2,3-dihydroxypropyl octadecanoate
NCGC00164529-02
NCGC00164529-03
NCGC00164529-04
NCGC00255004-01
NCGC00260122-01
Octadecanoic acid,3-dihydroxypropyl ester
1,2,3-Propanetriol 1-octadecanoyl ester
BS-50505
CAS-11099-07-3
FT-0626740
FT-0626748
FT-0674656
G0085
Octadecanoic acid, 2.3-dihydroxypropyl ester
D01947
EC 293-208-8
F71433
S-7950
A890632
A903419
SR-01000944874
Q-201168
Q5572563
SR-01000944874-1
W-110285
()-2,3-Dihydroxypropyl octadecanoate; 1-Glyceryl stearate; 1-Monooctadecanoylglycerol; 1-Monostearin
342394-34-7
InChI=1/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H
GLYCEROL STEARATE
CALCIUM GLYCEROPHOSPHATE, N° CAS : 27214-00-2 / 126-95-4 / 1336-00-1 / 58409-70-4 - Glycérophosphate de calcium, Nom INCI : CALCIUM GLYCEROPHOSPHATE Nom chimique : Calcium glycerophosphate, N° EINECS/ELINCS : 248-328-5 / 204-813-3 / 215-643-4 / 261-240-1, Le glycérophosphate de calcium aussi appelé glycérophosphate de chaux, se présente sous la forme d'une poudre blanche. Il est utilisé en cosmétique dans les dentifrices en tant qu'actif anti-plaques et anti-caries, il optimise l'action des fluorures.Antiplaque : Aide à protéger contre la formation de plaque dentaire Agent d'hygiène buccale : Fournit des effets cosmétiques à la cavité buccale (nettoyage, désodorisation et protection)
GLYCEROL TRIACETATE
DESCRIPTION:

Glycerol triacetate, is the organic compound with the formula C3H5(OCOCH3)3.
Glycerol triacetate is classified as a triglyceride, i.e., the triester of glycerol.
Glycerol triacetate is a colorless, viscous, and odorless liquid with a high boiling point and a low melting point.

CAS Number:102-76-1
EC Number: 203-051-9
IUPAC name: Propane-1,2,3-triyl triacetate
Molecular Weight: 218.20
Linear Formula: (CH3COOCH2)2CHOCOCH3


GLYCEROL TRIACETATE= TRIACETIN

CHEMICAL AND PHYSICAL PROPERTIES OF GLYCEROL TRIACETATE:
Chemical formula: C9H14O6
Molar mass: 218.205 g•mol−1
Appearance: Oily liquid
Density :1.155 g/cm3[3]
Melting point: −78 °C (−108 °F; 195 K)
at 760 mmHg
Boiling point: 259 °C (498 °F; 532 K)
at 760 mmHg
Solubility in water: 6.1 g/100 mL
Solubility: Miscible in EtOH
Soluble in C6H6, (C2H5)2O, acetone
Vapor pressure: 0.051 Pa (11.09 °C)
0.267 Pa (25.12 °C)
2.08 Pa (45.05 °C)[4]
ln(P/Pa)=22.819-4493/T(K)-807000/T(K)²
Refractive index (nD): 1.4301 (20 °C)
1.4294 (24.5 °C)
Viscosity: 23 cP (20 °C)
Thermochemistry:
Heat capacity (C): 389 J/mol•K
Std molar entropy (S⦵298): 458.3 J/mol•K
Std enthalpy of formation (ΔfH⦵298): −1330.8 kJ/mol
Std enthalpy of combustion (ΔcH⦵298): 4211.6 kJ/mol
Assay: ≥99.0% (GC)
Form: liquid
refractive index: n20/D 1.431
bp: 258-260 °C (lit.)
Density: 1.158 g/mL at 20 °C
Molecular Weight: 218.20
XLogP3: 0.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 8
Exact Mass: 218.07903816
Monoisotopic Mass: 218.07903816
Topological Polar Surface Area: 78.9 Ų
Heavy Atom Count: 15
Formal Charge: 0
Complexity: 229
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Boiling point: 258 ��C (1013 hPa)
Density : 1.161 g/cm3 (20 °C)
Explosion limit: 1.1 - 7.7 %(V)
Flash point: 148 °C
Ignition temperature: 430 °C
Melting Point: -78 °C
pH value: 5.0 - 6.0 (50 g/l, H₂O, 20 °C)
Vapor pressure: 0.003 hPa (25 °C)
Solubility: 64 g/l


Glycerol triacetate has a mild, sweet taste in concentrations lower than 500 ppm, but may appear bitter at higher concentrations.
Glycerol triacetate is one of the glycerine acetate compounds.
Glycerol triacetate is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.

Glycerol triacetate has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.
Glycerol triacetate has a role as a plant metabolite, a solvent, a fuel additive, an adjuvant, a food additive carrier, a food emulsifier, a food humectant and an antifungal drug.

Glycerol triacetate is functionally related to an acetic acid.
Glycerol triacetate is a natural product found in Vitis vinifera with data available.
A triglyceride that is used as an antifungal agent.
Glycerol triacetate is a triacetin compound that is used in the production of glycerol and glycerin.
The water vapor-resistant nature of this compound makes it an excellent candidate for use in projects where water vapor may be present.

Glycerol triacetate has been shown to have a high resistance to solid phase microextraction and can be used as a model system for studying the interactions of triacetates with other materials.
The reaction solution containing glycerol triacetate is acidic, which may lead to problems with water permeability if not properly treated.
This analytical method utilizes hydrogen bonding interactions between glycerol and glycerine molecules to measure the concentration of each component in the sample.

USES OF GLYCEROL TRIACETATE:
Glycerol triacetate is a common food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.
Glycerol triacetate is used as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent.

POTENTIAL USES OF GLYCEROL TRIACETATE:
The plasticizing capabilities of triacetin have been utilized in the synthesis of a biodegradable phospholipid gel system for the dissemination of the cancer drug paclitaxel (PTX).
In the study, triacetin was combined with PTX, ethanol, a phospholipid and a medium chain triglyceride to form a gel-drug complex.
This complex was then injected directly into the cancer cells of glioma-bearing mice.
The gel slowly degraded and facilitated sustained release of PTX into the targeted glioma cells.

Glycerol triacetate can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.
It has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.
It is believed to be safe to get over half of one's dietary energy from triacetin.

SYNTHESIS OF GLYCEROL TRIACETATE:
Glycerol triacetate was first prepared in 1854 by the French chemist Marcellin Berthelot.
Glycerol triacetate was prepared in the 19th century from glycerol and acetic acid.
Its synthesis from acetic anhydride and glycerol is simple and inexpensive.
3 (CH3CO)2O + 1 C3H5(OH)3 → 1 C3H5(OCOCH3)3 + 3 CH3CO2H

This synthesis has been conducted with catalytic sodium hydroxide and microwave irradiation to give a 99% yield of triacetin.
It has also been conducted with a cobalt(II) Salen complex catalyst supported by silicon dioxide and heated to 50 °C for 55 minutes to give a 99% yield of triacetin.

Safety:
The US Food and Drug Administration has approved it as Generally Recognized as Safe (GRAS) food additive and included it in the database according to the opinion from the Select Committee On GRAS Substances (SCOGS).
Glycerol triacetate and two types of acetooleins have been found to be without toxic effects in long-term feeding tests in rats at levels that were several orders of magnitude greater than those to which consumers are exposed.

Three types of acetostearins have been found to be without toxic effects in long-term feeding tests in rats at levels up to 5 g per kg per day.
This contrasts with an estimated human consumption of a fraction of a milligram per kg per day.
It is recognized that at an even higher feeding level (10 g per kg per day) male rats developed testicular atrophy and female rats, uterine discoloration.

However, such a level which would amount to 50 g or more for an infant and 600 g for an adult per day, is vastly higher than would be possible in the consumption of foods to which acetostearins are added for functional purposes.
Glycerol triacetate is included in the SCOGS database since 1975.

Glycerol triacetate was not toxic to animals in studies of exposure through repeated inhalation over a relatively short period.

SAFETY INFORMATION ABOUT GLYCEROL TRIACETATE:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



SYNONYMS OF GLYCEROL TRIACETATE:
MeSH Entry Terms:
Enzactin
Triacetin
Triacetyl glycerol
Triacetyl-glycerol
Triacetylglycerol
Depositor-Supplied Synonyms:
triacetin
102-76-1
Glyceryl triacetate
Glycerol triacetate
Enzactin
Glycerin triacetate
Triacetine
Triacetylglycerol
Fungacetin
Glyped
Triacetyl glycerine
Vanay
Kesscoflex TRA
Kodaflex triacetin
1,2,3-Propanetriol, triacetate
1,2,3-triacetoxypropane
Acetin, tri-
propane-1,2,3-triyl triacetate
1,2,3-Propanetriol, 1,2,3-triacetate
Triacetina
Triacetinum
1,2,3-Propanetriol triacetate
Triacetin [INN]
Ujostabil
Estol 1581
FEMA No. 2007
Triacetyl glycerin
Triacetyl glycerol
1,2,3-Propanetriyl triacetate
1,2,3-Triacetylglycerol
2,3-diacetyloxypropyl acetate
Glyceryltriacetate
NSC 4796
Triacetin (USP/INN)
Acetic, 1,2,3-propanetriyl ester
ENZACTIN (TN)
NSC-4796
Ins no.1518
1,2,3-triacetyl-glycerol
2-(Acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate
Ins-1518
1,2,3-triacetyl-sn-glycerol
CHEBI:9661
XHX3C3X673
E1518
E-1518
NCGC00091612-04
Triacetin (1,2,3-Propanetriol triacetate)
DSSTox_CID_6691
DSSTox_RID_78184
DSSTox_GSID_26691
FEMA Number 2007
Triacetine [INN-French]
Triacetinum [INN-Latin]
Triacetina [INN-Spanish]
CAS-102-76-1
HSDB 585
EINECS 203-051-9
TRIACETIN (GLYCEROL TRIACETATE)
BRN 1792353
Triacetin [USP:INN:BAN]
UNII-XHX3C3X673
Enzacetin
Euzactin
Fungacet
Motisil
Blekin
tri-acetin
AI3-00661
CCRIS 9355
Triacetin, CP
Triacetin, FCC
Triacetin, USP
3-Triacetoxypropane
Glycerine triacetate
MFCD00008716
Triacetin, 99%
Spectrum_000881
TRIACETIN [FCC]
TRIACETIN [II]
TRIACETIN [MI]
TRIACETIN [FHFI]
TRIACETIN [HSDB]
TRIACETIN [INCI]
Spectrum2_000939
Spectrum3_001368
Spectrum4_000362
Spectrum5_001376
TRIACETIN [VANDF]
TRIACETIN [MART.]
EC 203-051-9
Triacetin, >=99.5%
SCHEMBL3870
TRIACETIN [USP-RS]
TRIACETIN [WHO-DD]
BSPBio_002896
Glycerol triacetate tributyrin
KBioGR_000823
KBioSS_001361
4-02-00-00253 (Beilstein Handbook Reference)
MLS002152946
1,3-Propanetriol, triacetate
DivK1c_000740
Glyceryl triacetate, >=99%
SPECTRUM1500585
Triacetin, analytical standard
SPBio_000878
Triacetin, 99%, FCC, FG
1,2,3-propanediol triethanoate
CHEMBL1489254
DTXSID3026691
TRIACETIN [EP MONOGRAPH]
FEMA 2007
HMS502E22
KBio1_000740
KBio2_001361
KBio2_003929
KBio2_006497
KBio3_002116
NSC4796
TRIACETIN [USP MONOGRAPH]
NINDS_000740
HMS1921G05
HMS2092O09
HMS2232I22
Pharmakon1600-01500585
Triacetin, >=99%, natural, FG
HY-B0896
ZINC1530705
Tox21_111155
Tox21_201745
Tox21_300111
WLN: 1VO1YOV1 & 1OV1
CCG-39680
LMGL03012615
NSC757364
s4581
Triacetin, 8CI, BAN, INN, USAN
1,2,3-Propanetriol triacetate, 9CI
AKOS009028851
Tox21_111155_1
Glyceryl triacetate, >=99.0% (GC)
NSC-757364
1,3-bis(acetyloxy)propan-2-yl acetate
IDI1_000740
NCGC00091612-01
NCGC00091612-02
NCGC00091612-03
NCGC00091612-05
NCGC00091612-06
NCGC00091612-07
NCGC00091612-09
NCGC00254207-01
NCGC00259294-01
LS-13668
SMR001224538
SBI-0051540.P002
FT-0626753
G0086
EN300-19216
D00384
E 1518
E75962
Q83253
AB00052112_06
A800614
SR-05000002079
J-000781
SR-05000002079-1
2-(Acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate #
Z104473192
Triacetin, GTA F.G (1,2,3-PROPANETRIOL TRIACETATE)
Triacetin, United States Pharmacopeia (USP) Reference Standard
Triacetin, Pharmaceutical Secondary Standard; Certified Reference Material
1,2,3-Propanetriol triacetate; Glycerol Triacetate, USP Grade(1.03000); TRIACETINE; Glycerol triacetate; Glyceryl triacetate; propane-1,2,3-triyl triacetate

GLYCEROL TRIACETATE

Glycerol triacetate is a clear, viscous liquid with a sweet and fruity odor.
Glycerol triacetate is a colorless to pale yellow compound.
Glycerol triacetate has a molecular weight of approximately 218.21 grams per mole.

CAS Number: 102-76-1
EC Number: 203-051-9



APPLICATIONS


Glycerol triacetate is commonly used as a food additive and flavoring agent in the food industry.
Glycerol triacetate is employed as a solvent and excipient in pharmaceutical formulations.
Glycerol triacetate finds application in the production of confectionery items, providing enhanced flavor and mouthfeel.
Glycerol triacetate serves as a plasticizer in the manufacturing of plastics and films, improving their flexibility and durability.

Glycerol triacetate is utilized in the printing industry for the formulation of inks, improving ink flow and print quality.
Glycerol triacetate is used in the cosmetics industry as an emollient and fragrance enhancer in various personal care products.
Glycerol triacetate acts as a humectant in tobacco products, maintaining moisture levels and enhancing flavor.

Glycerol triacetate finds application in the production of adhesives and sealants, improving flexibility and adhesion properties.
Glycerol triacetate is used in the textile industry as a softening agent and lubricant for fibers and fabrics.
Glycerol triacetate serves as a solvent for various chemical reactions and experiments in laboratory settings.
Glycerol triacetate is employed in the agricultural industry as a formulation component in pesticides and herbicides.

Glycerol triacetate is used as a biodiesel additive, improving the performance and stability of biodiesel fuels.
Glycerol triacetate finds application in the leather industry as a softening agent and lubricant for leather processing.
Glycerol triacetate is utilized in metalworking fluids, improving lubricity and reducing friction during machining.

Glycerol triacetate serves as a coalescing agent in water-based coatings, aiding in film formation and performance.
Glycerol triacetate is used as a formulation component in insecticides and repellents in the pest control industry.
Glycerol triacetate finds application in the production of electrical capacitors and electronic components.
Glycerol triacetate is employed in metal plating processes as a leveling agent and brightener.

Glycerol triacetate can be used as a dielectric fluid or insulating material in electrical applications.
Glycerol triacetate is utilized in fuel cells as an electrolyte additive to enhance conductivity.
Glycerol triacetate finds application in gas chromatography as a reference standard or calibration compound.
Glycerol triacetate is used in smoke generators for special effects in theatrical productions or training simulations.

Glycerol triacetate serves as a solvent for resins, polymers, and cellulose derivatives in various applications.
Glycerol triacetate finds use in the inkjet printing industry for the formulation of stable inks.
Glycerol triacetate can be used as a solvent for cleaning and degreasing applications in automotive and manufacturing industries.


Some of its common applications include:

Food Industry:
Glycerol triacetate is used as a food additive and flavoring agent.
Glycerol triacetate enhances the taste and aroma of various food products, including confectionery, baked goods, beverages, and dairy products.

Pharmaceutical Industry:
Glycerol triacetate is utilized as a solvent and excipient in pharmaceutical formulations.
Glycerol triacetate helps improve the solubility and stability of active pharmaceutical ingredients in oral and topical medications.

Cosmetic and Personal Care Products:
Glycerol triacetate finds application in cosmetics and personal care products as a solvent, emollient, and fragrance enhancer.
Glycerol triacetate is used in items like lotions, creams, perfumes, and hair care products.

Plastics and Packaging:
Glycerol triacetate acts as a plasticizer in the production of plastics, films, and coatings.
Glycerol triacetate enhances flexibility, durability, and transparency in various plastic materials.

Printing Inks:
Glycerol triacetate is used in the formulation of printing inks, including those for flexographic and gravure printing.
Glycerol triacetate helps control ink viscosity and enhances ink transfer properties.

Tobacco Industry:
Glycerol triacetate is employed as a humectant and plasticizer in tobacco products, such as cigarettes and cigars.
Glycerol triacetate helps maintain moisture levels, enhance flavor, and improve the burning characteristics of tobacco.

Industrial Applications:
Glycerol triacetate serves as a solvent and intermediate in various industrial processes.
Glycerol triacetate is used in the production of adhesives, sealants, coatings, and lubricants.

Textile Industry:
Glycerol triacetate finds application in the textile industry as a softening agent and lubricant for fibers, yarns, and fabrics.
Glycerol triacetate helps improve the flexibility and handling of textile materials.

Specialty Chemicals:
Glycerol triacetate is used as a raw material for the synthesis of other chemicals and esters.
Glycerol triacetate serves as an important intermediate in the production of fragrances, flavors, and pharmaceutical ingredients.

Adhesives and Sealants:
Glycerol triacetate is used as a plasticizer and solvent in the formulation of adhesives and sealants.
Glycerol triacetate helps improve the flexibility and adhesion properties of these products.

Agricultural Industry:
Glycerol triacetate is used as a formulation component in agricultural products such as pesticides, herbicides, and insecticides.
Glycerol triacetate can aid in improving the stability and efficacy of these formulations.

Fuel and Energy:
Glycerol triacetate is utilized as a biodiesel additive and fuel oxygenate.
Glycerol triacetate can enhance the performance and stability of biodiesel fuels.

Leather Industry:
Glycerol triacetate finds application in the leather industry as a softening agent and lubricant for leather processing.
Glycerol triacetate helps improve the pliability and durability of leather goods.

Metalworking Fluids:
Glycerol triacetate is added to metalworking fluids, such as cutting oils and coolants, to improve lubricity and reduce friction during machining operations.

Water-based Coatings:
Glycerol triacetate can be used as a coalescing agent in water-based coatings and paints.
Glycerol triacetate aids in film formation and enhances the performance of these coatings.

Smoke Generation:
Glycerol triacetate is sometimes used in smoke generators for special effects, such as theatrical productions or training simulations.

Solvent for Resins and Polymers:
Glycerol triacetate serves as a solvent for various resins, polymers, and cellulose derivatives.
Glycerol triacetate helps dissolve these materials and facilitates their processing.

Electrical and Electronics Industry:
Glycerol triacetate is utilized in the manufacturing of electrical capacitors and electronic components as a dielectric fluid or insulating material.

Metal Plating:
Glycerol triacetate is employed in electroplating processes as a leveling agent and brightener for metal coatings.

Fuel Cell Electrolyte:
Glycerol triacetate is used as an electrolyte additive in fuel cells to enhance the performance and conductivity of the electrolyte solution.

Gas Chromatography:
Glycerol triacetate can be used as a reference standard or calibration compound in gas chromatography analysis.

Inkjet Printing:
Glycerol triacetate is utilized in the formulation of inks for inkjet printers, providing improved stability and ink flow characteristics.

Cleaning and Degreasing:
Glycerol triacetate can be used as a solvent for cleaning and degreasing applications, particularly in industries such as automotive and manufacturing.

Water Treatment:
Glycerol triacetate may be used in water treatment processes as a dispersant or solvent for certain chemicals or contaminants.



DESCRIPTION


Glycerol triacetate is a clear, viscous liquid with a sweet and fruity odor.
Glycerol triacetate is a colorless to pale yellow compound.
Glycerol triacetate has a molecular weight of approximately 218.21 grams per mole.

Glycerol triacetate is soluble in many organic solvents but has limited solubility in water.
Glycerol triacetate has a boiling point of around 258 degrees Celsius.

Glycerol triacetate is derived from the esterification of glycerol with acetic acid.
Glycerol triacetate is commonly used as a food additive, primarily as a flavoring agent and solvent.
Glycerol triacetate is considered safe for consumption in regulated quantities.

Glycerol triacetate is known for its ability to enhance the aroma and taste of food products.
Glycerol triacetate is used in the production of confectionery, baked goods, and beverages.

Glycerol triacetate acts as a plasticizer in the manufacturing of plastics, films, and coatings.
Glycerol triacetate exhibits low volatility, making it suitable for various applications.
Glycerol triacetate is often employed as a solvent in the pharmaceutical and cosmetic industries.
Glycerol triacetate is used in the production of printing inks and dyes.

Glycerol triacetate is compatible with a wide range of materials, including cellulose derivatives and resins.
Glycerol triacetate is known for its stability and resistance to oxidation and discoloration.
Glycerol triacetate has a relatively low freezing point, making it useful in low-temperature applications.
Glycerol triacetate can act as a viscosity modifier and lubricant.

Glycerol triacetate is often utilized as a humectant to retain moisture in products.
Glycerol triacetate is biodegradable and has low toxicity.
Glycerol triacetate is subject to regulatory guidelines and specifications regarding its use in various industries.

Glycerol triacetate may undergo hydrolysis under certain conditions, releasing acetic acid and glycerol.
Glycerol triacetate is stable under normal storage and handling conditions.
Glycerol triacetate has a wide range of applications in the food, pharmaceutical, and chemical industries.
Glycerol triacetate is recognized for its versatility, combining desirable properties as a solvent, plasticizer, and flavor enhancer.

Glycerol triacetate, also known as triacetin or triacetyl glycerol, is a chemical compound with the molecular formula C9H14O6.
Glycerol triacetate is an ester derived from glycerol and acetic acid.
Glycerol triacetate is a clear, colorless to pale yellow liquid with a slightly sweet odor.
Glycerol triacetate is commonly used as a food additive, a plasticizer, and a solvent in various industries.



PROPERTIES


Physical Properties:

Molecular Formula: C9H14O6
Molecular Weight: 218.21 g/mol
Appearance: Clear, colorless to pale yellow liquid
Odor: Slightly sweet and fruity odor
Density: 1.16 g/cm³
Boiling Point: Approximately 258 °C (496 °F)
Melting Point: -78 °C (-108.4 °F)
Solubility: Soluble in many organic solvents; limited solubility in water
Viscosity: High viscosity liquid
Refractive Index: 1.433 (at 20 °C)


Chemical Properties:

Glycerol triacetate is an ester derived from glycerol and acetic acid.
It undergoes esterification, forming three acetyl groups on the glycerol molecule.
The compound is stable under normal storage and handling conditions.
Glycerol triacetate is relatively resistant to oxidation and does not easily undergo discoloration.
It can undergo hydrolysis under certain conditions, breaking down into glycerol and acetic acid.
The compound is combustible and may emit acrid smoke and fumes when heated to decomposition.
Glycerol triacetate has low toxicity and is considered safe for specific applications and regulated quantities.



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
Provide artificial respiration if the person is not breathing.


Skin Contact:

Remove contaminated clothing and footwear.
Wash the affected area gently with mild soap and water for at least 15 minutes.
If irritation or redness develops, seek medical advice.
In case of chemical burns or extensive exposure, seek immediate medical attention.


Eye Contact:

Rinse the eyes immediately and thoroughly with gently flowing water for at least 15 minutes, ensuring to remove any contact lenses.
Keep the eyelids open to ensure thorough rinsing.
Seek immediate medical attention, even if there are no immediate symptoms.


Ingestion:

Rinse the mouth thoroughly with water.
Do not induce vomiting unless instructed to do so by medical professionals.
Seek immediate medical attention or contact a poison control center.
Do not give anything by mouth to an unconscious person.


General First Aid:

Ensure that the affected person is taken to a well-ventilated area.
Keep the person calm and provide reassurance.
If the person is unconscious, lay them in the recovery position and seek medical attention immediately.
In all cases of exposure, whether through inhalation, skin contact, eye contact, or ingestion, it is important to seek medical advice or consult a healthcare professional for further evaluation and treatment.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles, and protective clothing, to minimize skin and eye contact.

Ventilation:
Ensure adequate ventilation in the working area to prevent the buildup of vapors.

Avoid Ingestion:
Do not eat, drink, or smoke while handling Glycerol triacetate.

Prevent Inhalation:
Avoid inhaling vapors or mists.
Use local exhaust ventilation or respiratory protection if necessary.

Spill Management:
In case of spills, contain and absorb the material with an inert absorbent.
Avoid spreading the material or allowing it to enter drains or waterways.

Grounding and Bonding:
Use appropriate grounding and bonding techniques to prevent the buildup of static charges, as Glycerol triacetate is flammable.

Handling Equipment:
Use suitable equipment, such as pumps or closed systems, to transfer or handle Glycerol triacetate safely.

Avoid High Temperatures:
Store and handle the compound away from heat sources, open flames, and high temperatures to prevent ignition or decomposition.

Separate from Incompatible Materials:
Store Glycerol triacetate away from strong oxidizing agents, acids, and alkalis to prevent reactive hazards.

Labeling:
Ensure proper labeling of containers with the name of the substance and appropriate hazard warnings.


Storage:

Containers:
Store Glycerol triacetate in tightly sealed containers made of compatible materials, such as stainless steel, glass, or high-density polyethylene (HDPE).

Temperature:
Keep storage temperatures below 40°C (104°F) to maintain stability and prevent decomposition.

Ventilation:
Provide adequate ventilation in storage areas to prevent the buildup of vapors.

Fire Safety:
Store away from ignition sources and flammable materials. Follow local fire codes and regulations.

Sunlight Exposure:
Protect containers from direct sunlight or UV radiation, as it may degrade the compound over time.

Segregation:
Store Glycerol triacetate away from incompatible substances to prevent cross-contamination or reactive hazards.

Spill Containment:
Implement measures to contain spills, such as bunding or secondary containment, to prevent environmental contamination.

Storage Stability:
Follow recommended shelf-life guidelines and storage conditions provided by the manufacturer.

Accessibility:
Store Glycerol triacetate in a secure area, out of reach of unauthorized personnel, children, or animals.

Inventory Management:
Keep an inventory of stored quantities and conduct regular inspections to ensure proper storage conditions and identify any signs of deterioration or leakage.



SYNONYMS


Acetylated glycerol
Glycerin triacetate
Glyceryl triacetate
Triacetyl glycerol
Triacetin
Triacetate of glycerol
Glyceryl triacetate ester
Glycerol triacetic acid ester
Glycerol triacetyl ester
E1518 (E number)
TAA (abbreviation for Triacetin Acetate)
Acetyl glyceryl triester
Triacetate glycerin
Glycerol acetate triester
1,2,3-triacetoxypropane
Glycerin acetic acid ester
Glycerol acetate ester
Acetic acid glycerol ester
Triacetate of glycerin
Triacetate of glycerine
Acetin
Triglycol acetate
Glycerol triacetate ester
Glyceryl triacetic ester
Acetic acid triester of glycerol
Glycerol triethanoate
Triacetylglycerol
Glyceryl triethanoate
Glycerol acetate triester
Triacetin glyceryl ester
Acetyl glycerin triester
Acetic acid triester of glycerin
Glycerin triacetic acid ester
Glyceryl acetic acid ester
Acetylated glycerin
Glyceryl triacetyl ester
Triacetate glycerin
Glycerol acetate ester
Glycerin acetic acid ester
Acetic acid glycerin ester
Glyceryl acetyl ester
Glycerol triacetic ester
Triacetin glycerol ester
Triacetate of glycerine
Glycerol triacetate acetate
Glycerol triacetate ester
Acetic acid triester of glycerol
Triacetate of glycerol
Glycerol acetate triester
Acetylated glyceryl ester
Glyceryl triacetic ester
Glycerin triacetyl ester
Triacetate of glycerine
Acetin glycerol ester
Triacetyl glycerol
Triacetyl glycerine
Acetylated glyceryl triester
Acetic acid ester of glycerol
Triacetate of glyceric acid
Glycerol acetic acid ester
Glyceryl triethanoic ester
Acetyl glyceryl triethanoate
Glycerin triacetic acid ester
Triacetate of glyceric acid
Acetylated glycerol triester
Glycerol acetyl ester
Glycerin triacetyl ester
Acetylated glycerol acetate
Glycerol triacetyl acetate
Triacetin glyceryl acetate
Glycerol triethanoic acid ester
Acetyl glycerin triethanoate
Glycerin triacetyl acetate
Triacetate of glyceryl acetate
Glycerol triethanoic ester
GLYCEROL TRIACETATE (TRIACETIN)
Glycerol triacetate (triacetin) has a very faint, fruity odor.
Glycerol triacetate (triacetin) has a mild, sweet taste that is bitter above 0.05%.


CAS Number: 102-76-1
EC Number: 203-051-9
MDL number: MFCD00008716
E number: E1518 (additional chemicals)
Linear Formula: (CH3COOCH2)2CHOCOCH3
Molecular Formula: C9H14O6 / C3H5(OCOCH3)3


Glycerol triacetate (triacetin) is the triester of glycerol and acetylating agents, such as acetic acid and acetic anhydride.
Glycerol triacetate (triacetin) is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.
Glycerol triacetate (triacetin) derives from an acetic acid.


Glycerol triacetate (triacetin) has a very faint, fruity odor.
Glycerol triacetate (triacetin) has a mild, sweet taste that is bitter above 0.05%.
Glycerol triacetate (triacetin) is a colorless liquid; slight fatty odor; bitter taste.


Glycerol triacetate (triacetin) is slightly soluble in water; very soluble in alcohol, ether, and other organicsolvents.
Glycerol triacetate (triacetin) is a colorless, viscous liquid with a slightly fatty odor.
Glycerol triacetate (triacetin) is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.


Glycerol triacetate (triacetin) is an organic compound with the formula C3H5(OCOCH3)3.
Glycerol triacetate (triacetin) is a colorless, oily substance with a faint greasy smell.
Its high solvency power and low volatility makes Glycerol triacetate (triacetin) a good solvent and fixative for many flavors and fragrances.


Glycerol triacetate (triacetin) is obtained from acetic acid and glycerol.
Glycerol triacetate (triacetin) is more generally known as glycerin triacetate.
Glycerol triacetate (triacetin) is the triester of glycerol and acetic acid.


Glycerol triacetate (triacetin) is an artificial chemical compound, commonly used as a food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.
Glycerol triacetate (triacetin) is also a component of casting liquor with TG.


In a 1994 report released by five top cigarette companies, Glycerol triacetate (triacetin) was listed as one of the 599 cigarette additives.
The Glycerol triacetate (triacetin) is applied to the filter as a plasticizer.
Because Glycerol triacetate (triacetin) is in some sense the simplest possible fat, it is being considered a possible source of food energy in artificial food regeneration systems on long space missions.


Glycerol triacetate (triacetin) has fungistatic properties (based on release of acetic acid) and has been used in the topic.
Glycerol triacetate (triacetin) is a good solubilizer for insoluble ingredients and a fragrance fixative or carrier in perfume.
Glycerol triacetate (triacetin) has low volatility and color, high solvent power, and low toxicity.


It is believed to be safe to get over half of one's dietary energy from Glycerol triacetate (triacetin).
Glycerol triacetate (triacetin) is commercially prepared from acetic acid and glycerol.
Glycerol triacetate (triacetin) is non-toxic and non-irritating.


Glycerol triacetate (triacetin), CAS No.102-76-1, food emulsifier, manufacturing process through chemical synthesis from glycerol and Acetic Acid, available as Clear transparent oily liquid.
Glycerol triacetate (triacetin), also known as glyceryl triacetate, is pharmaceutical excipient used in manufacturing of capsules and tablets.


Glycerol triacetate (triacetin) is a colorless, oily substance with a faint greasy smell.
The triglyceride 1,2,3-triacetoxypropane is more generally known as Glycerol triacetate (triacetin) and glycerin triacetate.
Glycerol triacetate (triacetin) is the triester of glycerol and acetylating agents, such as acetic acid and acetic anhydride.


Glycerol triacetate (triacetin) is a triester of glycerin and acetic acid, a food-grade ingredient used as a solvent and carrier in pharmaceutical preparations and as a solvent and fixative in the compounding of perfumes and flavors.
Glycerol triacetate (triacetin) is a triester formed by the combination of glycerol and acetic acid.


This colorless, odorless, and hygroscopic liquid, Glycerol triacetate (triacetin), possesses a pleasant sweet taste.
Glycerol triacetate (triacetin) finds extensive use as a plasticizer and solvent across various applications, including the food, pharmaceutical, and cosmetic industries.


Glycerol triacetate (triacetin) is a colorless, oily liquid of slight fatty odor and bitter taste.
Glycerol triacetate (triacetin) is soluble with water and is miscible with alcohol and ether.
Glycerol triacetate (triacetin) functions in foods as a humectant and solvent.


Glycerol triacetate (triacetin) is a colourless, viscous and odorless liquid with a high boiling point.
Glycerol triacetate (triacetin) was first prepared in 1854 by the French chemist Marcellin Berthelot.
Glycerol triacetate (triacetin) is a glyceryl triacetate.


Glycerol triacetate (triacetin) acts as a plasticizer.
Glycerol triacetate (triacetin) is a clear liquid, free of suspended matter with a slight odor.
Its high solvency power and low volatility makes Glycerol triacetate (triacetin) a good solvent and fixative for many flavors and fragrances.


Glycerol triacetate (triacetin) is the organic compound with the formula C3H5(OCOCH3)3.
Glycerol triacetate (triacetin) is classified as a triglyceride, i.e., the triester of glycerol with acetic acid.
Glycerol triacetate (triacetin) is a colorless, viscous, and odorless liquid with a high boiling point and a low melting point.


Glycerol triacetate (triacetin) is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.
Glycerol triacetate (triacetin) is a triester of glycerin and acetic acid that occurs naturally in papaya.
The United States Food and Drug Administration affirmed Glycerol triacetate (triacetin) as generally recognized as safe (GRAS) for use in human food.


Glycerol triacetate (triacetin) is also generally recognized as safe in animal feeds, as a pesticide adjuvant, and in food packaging.
Glycerol triacetate (triacetin) is a liquid, and has been approved by the FDA as a food additive.
Glycerol triacetate (triacetin) is a water-soluble short-chain triglyceride that may also have a role as a parenteral nutrient according to animal studies.


Glycerol triacetate (triacetin) is listed on the FDA Generally Regarded As Safe (GRAS) List.
Glycerol triacetate (triacetin) is a triacetin compound that is used in the production of glycerol and glycerin.
The water vapor-resistant nature of Glycerol triacetate (triacetin) makes it an excellent candidate for use in projects where water vapor may be present.


Glycerol triacetate (triacetin) has a mild, sweet taste in concentrations lower than 500 ppm, but may appear bitter at higher concentrations.
Glycerol triacetate (triacetin) is one of the glycerine acetate compounds.
Glycerol triacetate (triacetin) is a natural product found in Vitis vinifera with data available.


Glycerol triacetate (triacetin) is a triglyceride that is used as an antifungal agent.
Glycerol triacetate (triacetin) is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.
Glycerol triacetate (triacetin) has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.


It is believed to be safe to get over half of one's dietary energy from Glycerol triacetate (triacetin).
Glycerol triacetate (triacetin) is an organic compound with the formula C3H5(OCOCH3)3.
Glycerol triacetate (triacetin) is classified as a triglyceride, i.e., the triester of glycerol.


Glycerol triacetate (triacetin) is a colorless, viscous, and odorless liquid with a high boiling point and a low melting point.
Glycerol triacetate (triacetin) has a mild, sweet taste in concentrations lower than 500 ppm, but may appear bitter at higher concentrations


Glycerol triacetate (triacetin) is also known as triacetin, and it appears as a clear colorless oily liquid.
Glycerol triacetate (triacetin) is a trihydric alcohol; the term “glycerol” generally applies only to the pure chemical compound 1,2,3-propanetriol, while the term “glycerine” applies to the purified commercial products normally containing more than 99,5% of glycerol.


Glycerol triacetate (triacetin) is one of the glycerine acetate compounds
Glycerol triacetate (triacetin) is the triester of glycerol.
Glycerol triacetate (triacetin) is a colorless, viscous and odorless liquid at room temperature.
Glycerol triacetate (triacetin) is a colorless, oily liquids with a sweet, creamy and fruity taste.


Glycerol triacetate (triacetin) is a natural ingredient from papayas.
Glycerol triacetate (triacetin) is also a Fungicide and a fragrance and flavor solvent.
Glycerol triacetate (triacetin) is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E1518.


Glycerol triacetate (triacetin) is a short-chain triglyceride, also known as glyceryl triacetate, which is obtained by a chemical process of acetylation of the three hydroxy groups of glycerol.
Glyceryl triacetate, also known as triacetin, is the triester of glycerol and acetic acid.


Glycerol triacetate (triacetin) is a synthetic compound that produces a clear, combustible, and oily liquid with a bitter taste that is used as a food additive with E number E1518.
Glycerol triacetate (triacetin) is slightly soluble in water but very soluble in ether or alcohol.


Glycerol triacetate (triacetin) is a glycerin triacetate molecule.
Glycerol triacetate (triacetin) is a triglyceride, triester of glycerol, food additive with E number E1518.
The triglyceride 1,2,3-triacetoxypropane is more generally known as triacetin and glycerin triacetate.


Glycerol triacetate (triacetin) is the triester of glycerol and acetylating agents, such as acetic acid and acetic anhydride.
Glycerol triacetate (triacetin) is a colorless, viscous and odorless liquid.
Glycerol triacetate (triacetin) is an artificial chemical compound, commonly used as a food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.



USES and APPLICATIONS of GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) is a triester of glycerin and acetic acid, a food-grade ingredient used as a solvent and carrier in pharmaceutical preparations and as a solvent and fixative in the compounding of perfumes and flavors.
Glycerol triacetate (triacetin) also serves as an ingredient in inks for printing on plastics and other nonabsorbent surfaces.


In nature, Glycerol triacetate (triacetin) is found in wine grapes and approved by FDA as a food additive.
Glycerol triacetate (triacetin) is easily hydrolyzed, releasing free acetic acid.
Processes requiring in situ generation of acid, such as textile dyeing, can utilize Glycerol triacetate (triacetin).


In skin care preparations, Glycerol triacetate (triacetin) exhibits fungistatic properties thanks to acetic acid released after hydrolysis.
Glycerol triacetate (triacetin) is used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.


The most important use of Glycerol triacetate (triacetin) is as a plasticizer for cigarette filters.
Glycerol triacetate (triacetin) can be used as a plasticizer and solvent for acetate fiber and nitrocellulose.
Glycerol triacetate (triacetin) is also used for natural rubber and synthetic rubber.


Glycerol triacetate (triacetin) is used plasticizing and does not affect vulcanization operations.
In the Food Industry: Glycerol triacetate (triacetin) has low toxicity and can be used as a mild fungicide for vegetables, fruits, animal glue and synthetic glue, and as a food additive, it can increase by 75% in volume.


In the Daily Chemical Industry: Glycerol triacetate (triacetin) can be used as a fixative and a moisturizing base for cosmetics, and can also be formulated into a non-alkaline and chlorine-free household bleach.
As a Gasoline Additive: Glycerol triacetate (triacetin) can reduce the amount of lead discharged in the air.


As an Additive to Anti-corrosion Materials: Glycerol triacetate (triacetin) has excellent corrosion resistance to hydrocarbons.
In the Printing and Dyeing Industry: Glycerol triacetate (triacetin) can be used as a swelling agent and stabilizer for cellulose acetate;Ink, cellulose, film and some alkaline solvents are also used as plasticizers for synthetic plastic films.


Glycerol triacetate (triacetin) can be used in Food, Beverage, Pharmaceutical, Health & Personal care products, Agriculture/Animal Feed/Poultry.
Food grade Glycerol triacetate (triacetin) used in manufacturing of capsules and tablets, used as a humectant, plasticizer, and solvent.
Glycerol triacetate (triacetin) is used in Tobacco industry, Dairy food, hard candy, butter and beverage, Chewing gum, Bakes food.


In skin and hair care applications Glycerol triacetate (triacetin) can be used as an antimicrobial agent, film forming, hair dyeing, plasticizer, or a solvent that is also compatible with cellulose.
Glycerol triacetate (triacetin) has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.


Glycerol triacetate (triacetin) has a role as a plant metabolite, a solvent, a fuel additive, an adjuvant, a food additive carrier, a food emulsifier, a food humectant and an antifungal drug.
Glycerol triacetate (triacetin) is a triglyceride that is used as an antifungal agent.


Glycerol triacetate (triacetin) is used as cellulose plasticizer for cigarette filters; in binders for solid rocket fuels; as fixative in perfumes; to make cosmetics and pharmaceuticals.
Glycerol triacetate (triacetin) is used as solvent for celluloid and photographic films; to remove carbon dioxide from natural gas; and as topical antifungal medication.


In Food: Glycerol triacetate (triacetin) can be used as humectant, emlusifier, binder in food such as in baked goods, beverages, chewing gum, flavoring agents, dairy desserts, cheese, processed fruit, dried vegetables, confectionery.
In Beverage: Glycerol triacetate (triacetin) can be used as emulsifier, flavor enhancer in beverage.


In Pharmaceutical: Glycerol triacetate (triacetin) can be used as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent in Pharmaceutical.
In Agriculture/Animal Feed/Poultry feed: Glycerol triacetate (triacetin) can be used as feed ingredients in agriculture/animal feed/poultry feed.


Glycerol triacetate (triacetin) is used as core sand binder in metal foundry sector.
Glycerol triacetate (triacetin) is used as solvent in printing inks.
Glycerol triacetate (triacetin) is used as a highly effective plasticizer for cellulose-based plastics.


Glycerol triacetate (triacetin) is used as solvent in building wall coating.
Mostly, Glycerol triacetate (triacetin) is used in the food and cosmetics industry.
Here Glycerol triacetate (triacetin) can be found in chewing gum as a softener or as a flavor carrier.


Glycerol triacetate (triacetin) as an antimicrobial effect which is why it is used as an emollient and as a humectant.
Within the European Union Glycerol triacetate (triacetin) is allowed to be added to food solely in chewing gum and as a flavor carrier.
Glycerol triacetate (triacetin) can be identified by its e-number (E1518).


Technical Glycerol triacetate (triacetin) (mixture of mono-, di-, and small quantities of triacetin) used as a solvent for basic dyes (especially indulines) and tannin in dyeing.
Glycerol triacetate (triacetin) is used in cigarette filters.


Glycerol triacetate (triacetin) is used skin sensitization reported in a worker at a cigarette manufacturing plant.
Glycerol triacetate (triacetin) is used as chromatographic fixative, solvent, toughening agent and fragrance fixative.
Glycerol triacetate (triacetin) is used as plasticizer and fragrance fixative, ink solvent.


Glycerol triacetate (triacetin) is also used in the synthesis of medicine and dyes; humectant; carrier solvent; plasticizer; natural gas absorb carbon dioxide.
Glycerol triacetate (triacetin) is allowed to be used in spices.


Glycerol triacetate (triacetin) is used food additive as a solvent for other additives, especially flavors.
Glycerol triacetate (triacetin) can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.


Glycerol triacetate (triacetin), also known as glyceryl triacetate, is pharmaceutical excipient used in manufacturing of capsules and tablets.
Glycerol triacetate (triacetin) is also used as a humectant, plasticizer, and solvent.
Glycerol triacetate (triacetin) is also used in the food, perfume and cosmetic industries.


Glycerol triacetate (triacetin) is used as a carrier, solvent or as a wetting agent.
Glycerol triacetate (triacetin) is added to chewing gum, alcoholic and non-alcoholic beverages, food additives.
In addition to food, Glycerol triacetate (triacetin) is added to toothpaste, hair dyes, cigarette filters or perfumes.


Glycerol triacetate (triacetin) is used as a binder for solid rocket fuels.
Glycerol triacetate (triacetin) is used Fungicide, humectant and solvent for flavours derived from glycerol and acetic acid.
Glycerol triacetate (triacetin) can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of bio diesel.


Glycerol triacetate (triacetin) is used as spice fixative, solvent, toughening agent.
Glycerol triacetate (triacetin) is used in the production of cosmetics, medicines and dyes, as a plasticizer for cigarette filter rods, etc.
Glycerol triacetate (triacetin) is used Substrate for determination of lipase, fragrance fixative.


Glycerol triacetate (triacetin) is used as fixative in perfumery; solvent in manufacture of celluloid, photographic films.
Technical Glycerol triacetate (triacetin) (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.


Glycerol triacetate (triacetin) is also a component of casting liquor with TG and as an excipient in pharmaceutical products where it is used as a humectant, a plasticiser, and as a solvent.
Glycerol triacetate (triacetin) is used to coat fresh fruit in the US, essences, cigarette filters, as a solvent in flavourings, and for its humectant function.


Glycerol triacetate (triacetin) is used in chewing gum and other food contact related plastic compound.
Glycerol triacetate (triacetin) has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.


Glycerol triacetate (triacetin) has a role as a plant metabolite, a solvent, a fuel additive, an adjuvant, a food additive carrier, a food emulsifier, a food humectant and an antifungal drug.
Glycerol triacetate (triacetin) is also used for natural rubber and synthetic rubber.


Glycerol triacetate (triacetin) is functionally related to an acetic acid.
Glycerol triacetate (triacetin) is a common food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.


Glycerol triacetate (triacetin) is used as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent.
The plasticizing capabilities of Glycerol triacetate (triacetin) have been utilized in the synthesis of a biodegradable phospholipid gel system for the dissemination of the cancer drug paclitaxel (PTX).


Glycerol triacetate (triacetin) has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.
Glycerol triacetate (triacetin) is mainly used as a synthetic flavoring agent in ice-creams, nonalcoholic beverages and baked goods.


Glycerol triacetate (triacetin) is used as plasticizer.
Glycerol triacetate (triacetin) is used as curing agent.
Glycerol triacetate (triacetin) is used as fragrance fixing agent.


Glycerol triacetate (triacetin) is used as fiber solvent.
The most important use of Glycerol triacetate (triacetin) is as a plasticizer for cigarette filters.
Glycerol triacetate (triacetin) can be used as a plasticizer and solvent for acetate fiber and nitrocellulose.


In the study, Glycerol triacetate (triacetin) was combined with PTX, ethanol, a phospholipid and a medium chain triglyceride to form a gel-drug complex.
Glycerol triacetate (triacetin) was then injected directly into the cancer cells of glioma-bearing mice.
Glycerol triacetate (triacetin) slowly degraded and facilitated sustained release of PTX into the targeted glioma cells.


Glycerol triacetate (triacetin) can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.
Glycerol triacetate (triacetin) is used Solvent for flavors & fragrance, Cosmetic fixative, Food additive (E1518), Plasticizer in chewing gu, and Plasticizer for cigarette filter tips.


Glycerol triacetate (triacetin) is used in ink coating, cellulose nitrate, cellulose acetate, ethyl cellulose and cellulose acetate butyrate plasticizer and solvent, and Plasticizer and curing agent in foundry resins.
Glycerol triacetate (triacetin) is used primarily for flavors and extracts, as well as chewing pastes.


Glycerol triacetate (triacetin) is used Softening agents in thickeners.
Since Glycerol triacetate (triacetin) also has a moisturizing effect, it is used as a plasticizer for plastics and as a solubilizer for paint, textile, paper and leather treatment agents.


Glycerol triacetate (triacetin) is plasticizing and does not affect vulcanization operations.
In the Food Industry: Glycerol triacetate (triacetin) has low toxicity and can be used as a mild fungicide for vegetables, fruits, animal glue and synthetic glue, and as a food additive, it can increase by 75% in volume.


In the Daily Chemical Industry: Glycerol triacetate (triacetin) can be used as a fixative and a moisturizing base for cosmetics, and can also be formulated into a non-alkaline and chlorine-free household bleach.
As a Gasoline Additive: Glycerol triacetate (triacetin) can reduce the amount of lead discharged in the air.


As an Additive to Anti-corrosion Materials: Glycerol triacetate (triacetin) has excellent corrosion resistance to hydrocarbons.
In the Printing and Dyeing Industry: Glycerol triacetate (triacetin) can be used as a swelling agent and stabilizer for cellulose.
Glycerol triacetate (triacetin) is also widely employed in laboratory settings as a buffer, stabilizer, or solvent.


Both substances are readily absorbed, broken down and used calorically by the body.
Glycerol triacetate (triacetin) is used in Food, Beverage, Pharmaceutical, Health & Personal care products.
Glycerol triacetate (triacetin) is used as an emulsifier, an agent that forms or preserves a mixture of substances that are normally immiscible, such as oil and water.


Glycerol triacetate (triacetin) is also used as a humectant, a substance that helps prevent food from drying out.
In beverage, Glycerol triacetate (triacetin) is used as emulsifier and flavor enhancer.
Glycerol triacetate (triacetin) is one of the few food grade carrier for flavors and fragrances.


Glycerol triacetate (triacetin) is used in food and cosmetic products.
It’s high solvency power and high volatility make Glycerol triacetate (triacetin) a good solvent and fixative for flavors and fragrances.
Glycerol triacetate (triacetin) is a triester of glycerol manufactured through chemical synthesis, available as Clear transparent oily liquid.


Glycerol triacetate (triacetin) is widely used as emulsifier.
Cosmetics and fragrances: Glycerol triacetate (triacetin) is used Humectant, plasticiser, solvent and fixative for fragrances, also used in dye synthesis and perfume fixative.


Antimicrobial agent: Glycerol triacetate (triacetin) is able to suppress or inhibit the growth and replication of a broad spectrum of microorganisms such as bacteria, fungi and viruses by making the stratum corneum temporarily bactericidal and fungicidal.
Film-forming agent: Glycerol triacetate (triacetin) produces, upon application, a very thin continuous film with an optimal balance of cohesion, adhesion and stickiness on skin, hair or nails to counteract or limit damage from external phenomena such as chemicals, UV rays and pollution.


Notably, Glycerol triacetate (triacetin) displays amphiphilic properties, enabling it to interact with both polar and non-polar molecules. his unique characteristic allows for the dissolution and stabilization of a wide range of compounds.
Moreover, Glycerol triacetate (triacetin) has been found to have diverse biochemical and physiological effects.


Glycerol triacetate (triacetin) has demonstrated the ability to inhibit specific enzymes such as cyclooxygenase and lipoxygenase.
Additionally, Glycerol triacetate (triacetin) has shown a reduction in the expression of certain genes involved in inflammation and cancer.
Moreover, Glycerol triacetate (triacetin) has exhibited a variety of biological activities, including anti-inflammatory, antioxidant, and antimicrobial properties.


Glycerol triacetate (triacetin) is often used as a food additive because of its wetting, solvent and plasticizer properties.
In pharmaceuticals, Glycerol triacetate (triacetin) is used as a plasticizer in the production of gelatin capsules.
In cosmetics, Glycerol triacetate (triacetin) is used for its moisturizing and emollient properties.


Glycerol triacetate (triacetin)-mediated acetate supplementation may provide a new safe chemotherapeutic adjuvant to reduce the growth of glioma tumours, particularly the more rapidly proliferating glycolytic and hypoacetylated mesenchymal glioma tumours.
Glycerol triacetate (triacetin) is used as a substrate for lipase determination.


Labelled as a humectant with the number E1518 in the European food additives list.
Glycerol triacetate (triacetin) is used in cooking food and dairy products to promote fermentation.
Glycerol triacetate (triacetin) is used Chromatographic fixative, solvent, hardener, curing agent that can absorb carbon dioxide from natural gas.


Furthermore, Glycerol triacetate (triacetin) has demonstrated the ability to hinder the growth of specific cancer cells and mitigate the toxicity of certain drugs.
Thus, in the realm of scientific research, Glycerol triacetate (triacetin) finds extensive applications in vitro studies.


In summary, Glycerol triacetate (triacetin) is a versatile triester utilized as a plasticizer, solvent, and stabilizer.
With its amphiphilic nature, Glycerol triacetate (triacetin) can interact with a wide range of molecules, dissolve various compounds, and stabilize solutions.


Glycerol triacetate (triacetin) has shown significant biochemical and physiological effects, such as enzyme inhibition and gene expression modulation.
Furthermore, Glycerol triacetate (triacetin)'s applications extend to diverse areas of scientific research, offering valuable contributions to in vitro studies.


Glycerol triacetate (triacetin) is used Environmentally friendly plasticiser containing no phthalates.
Glycerol triacetate (triacetin) can be used as a plasticiser and solvent of printing ink, nitrocellulose, cellulose acetate, ethacellulose and ellulose acetate butyrate.
In casting, Glycerol triacetate (triacetin) is used as a moulding sand hardener.


Application generally takes place in a spray chamber where Glycerol triacetate (triacetin) is applied to the filter in the form of an aqueous aerosol.
Glycerol triacetate (triacetin) is used in the food industry as a solvent for flavouings, and is used as a humectant in pharmaceutical products.
Glycerol triacetate (triacetin) is also used as a plasticiser and a solvent.


Glycerol triacetate (triacetin) is approved to use as food additive in EU.
Glycerol triacetate (triacetin) is used Plasticizer for paints and adhesives, additive for special hardeners, adhesive for cigarette filter production, plasticizer for chewing gum or as a flavor carrier, food additive E 1518.


Glycerol triacetate (triacetin) is also a component of casting liquor with TG and as an excipient in pharmaceutical products where it is used as a humectant, a plasticizer, and as a solvent.
Glycerol triacetate (triacetin) can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.


Glycerol triacetate (triacetin) is used food ingredients, HTF - food/feed/beverage processing, Other-food chemicals, and Packaging inks non-food contact.
Glycerol triacetate (triacetin) is used as an ingredient in many food and cosmetic products.
Glycerol triacetate (triacetin)'s high solvency power and low volatility make triacetin a good solvent and fixative for many flavors and fragrances.


Glycerol is a very well-known substance which counts a great variety of applications: HUMECTANT, solvent, and SWEETENER in foodstuff, additive or solvent in the manufacture of perfumes, inks or automobile antifreeze, humectant in tobacco industry, plasticizer and lubricants for the plastic industry, smoothing agent, emollient, lubricant and humectant in personal care preparations and pharmaceutical products where in some cases has the function of ACTIVE PRINCIPLE INGREDIENT, such as in GLYCEROL SUPPOSITORIES.


One of Glycerol triacetate (triacetin)'s main uses is as a plasticizer in chewing gum.
Glycerol triacetate (triacetin) is often used as a food additive, for instance as a solvent in flavourings, and for its humectant function.
Glycerol triacetate (triacetin) is mainly used in dairy products, cheese, processed fruit, dried vegetables, confectionery, etc.


Glycerol triacetate (triacetin) has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.
It is believed to be safe to get over half of one's dietary energy from Glycerol triacetate (triacetin).
Glycerol triacetate (triacetin) also has some anti-fungal activity.


Glycerol triacetate (triacetin) is used as a plasticizer and fragrance fixative, ink solvent, also used in medicine and dye synthesis.
Glycerol triacetate (triacetin) is used as a chromatographic fixative, solvent, toughener and fragrance fixative.
Humectants; carrier solvents; plasticizers; Glycerol triacetate (triacetin) can absorb carbon dioxide from the natural gas.


Glycerol triacetate (triacetin) is used in the production of cosmetics, pharmaceuticals and dyes, plasticizers for cigarette filter rods, and so on.
Glycerol triacetate (triacetin) is used applied in cosmetics, casting, medicine, dyes and other industries.
Glycerol triacetate (triacetin) is non-toxic, non-irritating.


Glycerol triacetate (triacetin) is used as the substrate for the determination of lipase, perfume fixative, solvent, gas chromatographic fixative (maximum temperature of 85 ℃, solvent: methanol, chloroform), separation of gas and aldehyde analysis.
Glycerol triacetate (triacetin) is an organic compound which is widely used in food, flavors & fragrances, pharmaceutical, cigarette, plasticiser, foundry, and textiles.


Glycerol triacetate (triacetin) has been shown to have a high resistance to solid phase microextraction and can be used as a model system for studying the interactions of triacetates with other materials.
Glycerol triacetate (triacetin) is pharmaceutical excipient used in manufacturing of capsules and tablets, and has been used as a humectant, plasticizer, and solvent.


The reaction solution containing Glycerol triacetate (triacetin) is acidic, which may lead to problems with water permeability if not properly treated.
This analytical method utilizes hydrogen bonding interactions between glycerol and glycerine molecules to measure the concentration of each component in the sample.
Glycerol triacetate (triacetin) is also used in the perfume and cosmetic industries.


-Pharmaceutical Applications:
Glycerol triacetate (triacetin) is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.
Glycerol triacetate (triacetin) is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.


-In Health and Personal care
Glycerol triacetate (triacetin), an oil, is the triester of Glycerol and Acetic Acid.
In cosmetics and personal-care products, Glycerol triacetate (triacetin) is used in makeup as well as in nail polish and nail enamel removers.
Glycerol triacetate (triacetin) helps cleanse the skin or prevent odor by destroying or inhibiting the growth of microorganisms.
Glycerol triacetate (triacetin) is also a plasticizer and commonly used carrier for flavors and fragrances.


-Fragrance:
Glycerol triacetate (triacetin) plays a decisive and important role in the formulation of cosmetic products as it provides the possibility of enhancing, masking or adding fragrance to the final product, increasing its marketability.
Glycerol triacetate (triacetin) is able to create a perceptible pleasant odour, masking a bad smell.
The consumer always expects to find a pleasant or distinctive scent in a cosmetic product.


-Clinical Use of Glycerol triacetate (triacetin):
Glycerol triacetate (triacetin) is a colorless, oilyliquid with a slight odor and a bitter taste.
Glycerol triacetate (triacetin) issoluble in water and miscible with alcohol and most organicsolvents.
The activity of Glycerol triacetate (triacetin) is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin.
Acid release is a self-limiting process because the esterases are inhibited below pH 4.


-Plasticiser uses of Glycerol triacetate (triacetin).
Glycerol triacetate (triacetin) is added to the formulation with the purpose of retaining fragrance and colour, increasing flexibility, flowability, deformability, durability of various ingredients allowing better processing.
Glycerol triacetate (triacetin) softens and makes flexible synthetic polymers that otherwise could not be easily processed, stretched or deformed.


-Solvent uses of Glycerol triacetate (triacetin):
Glycerol triacetate (triacetin) is the substance for dissolving or dispersing surfactants, oils, dyes, flavourings, bactericidal preservatives in solution.
In fact, Glycerol triacetate (triacetin) dissolves other components present in a cosmetic formulation.
Solvents are generally liquid (aqueous and non-aqueous).


-Medical uses of Glycerol triacetate (triacetin):
Glycerol triacetate (triacetin) is both the shortest chain triglyceride (SCT), which contains fatty acids with two carbon atoms, and the only triglyceride that is up to 6 per cent soluble in water.
Glycerol triacetate (triacetin)'s approval by the Food and Drug Administration as a safe human food ingredient has led to a series of studies examining its potential as a therapeutic agent.



FOOD USES OF GLYCEROL TRIACETATE (TRIACETIN):
As a food additive, the influence of the choice of aromatic solvent between propylene glycol (PG) or Glycerol triacetate (triacetin) (TA) was investigated during the accelerated shelf life test (ASL) of biscuits and tartlets.
In particular, the differential effect on the stability of added vanillin, the natural baked marker compound 5- (hydroxymethyl) furfural (HMF), specific oxidative rancidity markers (2,4-decadienal, 2,4-heptadienal) and the structural parameters of hardness and fractureability.

More HMF was formed during baking of biscuits prepared with Glycerol triacetate (triacetin); these biscuits were also more stable to oxidative degradation and vanillin loss during ageing than biscuits prepared with PG.
Fresh Glycerol triacetate (triacetin) biscuits were significantly more brittle than fresh PG biscuits.

There was no impact of the choice of solvent on hardness.
Sensory evaluation of hardness, vanilla flavour and oily note were tested during the ASL-tests.
There was no significant impact on the retention of sensory ratings for PG or Glycerol triacetate (triacetin) biscuits.



FUCTION AND CHARACTERISTICS OF GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) is used as a solvent for flavours; it also has some anti-fungal activity.


DIETARY RESTRICTIONS OF GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) can be used by all religious groups, vegetarians and vegans.



FUNCTIONS OF GLYCEROL TRIACETATE (TRIACETIN):
1. Flavor / Flavoring / Flavor Enhancer - Provides or enhances a particular taste or smell.
2. Fragrance / Fragrance Component - Provides or enhances a particular smell or odor.
3. Humectant - Binds with water to increase skin hydration. Also enhances water absorption of the skin



CHEMICAL PROPERTIES OF GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) has a very faint, fruity odor. It has a mild, sweet taste that is bitter above 0.05%.
Glycerol triacetate (triacetin) is a colorless liquid; slight fatty odor; bitter taste.
Glycerol triacetate (triacetin) is slightly soluble in water; very soluble in alcohol, ether, and other organic solvents.

Glycerol triacetate (triacetin) is a colorless, viscous liquid with a slightly fatty odor.
Glycerol triacetate (triacetin) is a colorless, odorless oily liquid. It is miscible with ethanol, ether, benzene, chloroform and other organic solvents, soluble in acetone, insoluble in mineral oil.
Glycerol triacetate (triacetin) is slightly soluble in water. 25 ° C in water solubility of 5.9g / 100ml.



FUNCTIONS OF GLYCEROL TRIACETATE (TRIACETIN):
*Fatty Acids & Lipids
*Flavoring Agent
*Solubilizer
*Solvent
*Carrier
*Antiseptic



WHAT IS GLYCEROL TRIACETATE (TRIACETIN) AND HOW DOES GLYCEROL TRIACETATE (TRIACETIN) WORK?
Glycerol triacetate (triacetin) (glycerine triacetate and 1,2,3-propanetriyl triacetate) is an ester compound of glycerin and acetic acid.
Glycerol triacetate (triacetin) is a colorless liquid that smells oily to rancid.
Glycerol triacetate (triacetin)´s used as an emollient, as a humectant or as a flavor carrier in various industries.
Glycerol triacetate (triacetin) has a viscosity (7.83 cSt at 40 oC) .



FUNCTIONAL CLASS OF GLYCEROL TRIACETATE (TRIACETIN):
*Flavouring Agent
*FLAVOURING_AGENT
*Food Additives
*CARRIER_SOLVENT
*HUMECTANT



MORE ADDITIVES AND FOOD ADDITIVES OF GLYCEROL TRIACETATE (TRIACETIN):
*Shellac wax
*Conditioning agents
*Solvents
*Fumaric acid
*Flame retardants
*Maleic anhydride functionalized polymers



PRODUCTION METHODS OF GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) is prepared by the esterification of glycerin with acetic anhydride.


PREPARATION OF GLYCEROL TRIACETATE (TRIACETIN):
By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.



MANUFACTURING PROCESS OF GLYCEROL TRIACETATE (TRIACETIN):
200 grams of allyl acetate, 450 grams of glacial acetic acid and 3.71 grams of cobaltous bromide were charged to the reactor and the mixture was heated to 100°C.
Pure oxygen was then introduced into the reactor below the surface of the liquid reaction mixture at the rate of 0.5 standard cubic feet per hour.

Initially, all of the oxygen was consumed, but after a period of time oxygen introduced into the mixture passed through unchanged.
During the course of the reaction, a small quantity of gaseous hydrogen bromide (a total of 1.9 grams) was introduced into the reaction zone, along with the oxygen.

The reaction was allowed to continue for 6 hours following which the reaction mixture was distilled.
Essentially complete conversion of the allyl acetate took place.
A yield of 116 grams of Glycerol triacetate (triacetin) was obtained, this being accomplished by distilling the Glycerol triacetate (triacetin) overhead from the reaction mixture, at an absolute pressure of approximately 13 mm of mercury.



PRODUCTION OF GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) can be derived from the esterification of glycerol and acetic acid.
After preheating glycerol to 50-60 ° C, add acetic acid, benzene and sulfuric acid.
Heat and stir for refluxing dehydration, and recycle the benzene.
Then add acetic anhydride for heating of 4h.

After cooling, the mixture was neutralized with 5% sodium carbonate to pH 7, and the crude layer was dried and the crude oil was dried with calcium chloride.
Distill under reduced pressure, collect the 128-131 ° C (0.93 kPa) fraction, namely Glycerol triacetate (triacetin).



FOOD ADDITIVES OF GLYCEROL TRIACETATE (TRIACETIN):
*Polyglycerol polyricinoleate
*Citrate
*Potassium metabisulphite / Potassium disulphite
*Sugar substitutes
*Flavorants / fragrances
*E vitamins



PRODUCTION OF GLYCEROL TRIACETATE (TRIACETIN):
For commercial use, Glycerol triacetate (triacetin) is produced synthetically from acetic acid and glycerol.



SYNTHESIS OF GLYCEROL TRIACETATE (TRIACETIN):
Glycerol triacetate (triacetin) was first prepared in 1854 by the French chemist Marcellin Berthelot.
Glycerol triacetate (triacetin) was prepared in the 19th century from glycerol and acetic acid.
Glycerol triacetate (triacetin)'s synthesis from acetic anhydride and glycerol is simple and inexpensive.
3 (CH3CO)2O + 1 C3H5(OH)3 → 1 C3H5(OCOCH3)3 + 3 CH3CO2H

This synthesis has been conducted with catalytic sodium hydroxide and microwave irradiation to give a 99% yield of Glycerol triacetate (triacetin).
Glycerol triacetate (triacetin) has also been conducted with a cobalt(II) Salen complex catalyst supported by silicon dioxide and heated to 50 °C for 55 minutes to give a 99% yield of Glycerol triacetate (triacetin).



SAFETY OF GLYCEROL TRIACETATE (TRIACETIN):
The US Food and Drug Administration has approved it as Generally Recognized as Safe food additive and included it in the database according to the opinion from the Select Committee On GRAS Substances (SCOGS).
Glycerol triacetate (triacetin) is included in the SCOGS database since 1975.



CONTENT ANALYSIS OF GLYCEROL TRIACETATE (TRIACETIN):
Accurately weigh about 1g of the sample, put it into a suitable pressure bottle, add 25 mL of 1mol / L. potassium hydroxide solution and 15 mL of isopropyl alcohol, add stopper, wrap with cloth and put it in a canvas bag.
Put it into the water bath of 98 ℃ ± 2 ℃ for 1h, and the water level in the water bath should be slightly higher than the bottle level.

Take the bottle out from the bag, cool it to room temperature in the air, unfold the cloth and stopper to release the residual pressure in the bottle, and then remove the cloth.
Add 6 to 8 drops of phenolphthalein test solution (TS-167), apply 0.5mol / L sulfuric acid for titration of excess alkali until the pink could just disappeared.

At the same time, perform a blank test.
Each mL of 0.5mol / L sulfuric acid is equivalent to 36.37 mg of Glycerol triacetate (triacetin) (C9H14O6).



THE NAME DEFINES THE STRUCTURE OF GLYCEROL TRIACETATE (TRIACETIN) MOLECULE:
Glycerol triacetate (triacetin) refers to a triester that is derived from glycerol and acetic acid.
The prefix "tri-" indicates that there are three acetic acid molecules esterified to each glycerol molecule.
The synthesis process of Glycerol triacetate (triacetin) takes place in several stages:

*Preparation of glycerin:
The process begins with the preparation of glycerin, which is commercially available.

*Esterification:
Glycerol reacts with acetic acid in the presence of an acid catalyst, often sulfuric acid.
The reaction is heated, which initiates the esterification process.
This reaction causes the formation of Glycerol triacetate (triacetin) and water.

*Separation:
The reaction mixture is allowed to cool.
Glycerol triacetate (triacetin), being less polar than water, will separate from the reaction mixture.

*Purification:
Glycerol triacetate (triacetin) is then purified.
This typically involves distillation, where Glycerol triacetate (triacetin) is heated and vapors are collected and condensed.
This process helps to remove any remaining impurities.

*Quality control:
The final product is tested to ensure it meets the specifications required for use in the intended applications.
This includes checking its purity, color and smell.

It is in the form of an odourless and colourless clear liquid, starts to sublimate when heated to 160°C and at 300°C, decomposes to chlorine and phosphorus trichloride.
Soluble in water, soluble in carbon disulphide, carbon tetrachloride and benzoyl chloride.
In moist air it is hydrolysed into phosphoric acid and hydrochloric acid.



PHYSICAL and CHEMICAL PROPERTIES of GLYCEROL TRIACETATE (TRIACETIN):
Appearance: Clear, colorless, odorless liquid
Triacetin content: ≥99.5%
Acidity (As HAC): ≤0.01%
Moisture: ≤0.05%
Color, Pt-Co: ≤15
Refractive Index (20℃): 1.430-1.433
Specific Gravity (20℃): 1.157-1.162
As: ≤0.0001
Pb: ≤0.0005
Residue on Ignition: ≤0.05
CAS: 102-76-1
Molecular Formula :C9H14O6
Molecular Weight: 218.20
Storage Details: Ambient
Harmonised Tariff Code: 29153900
Refractive Index: 1.4300 - 1.4332 @ 20 Deg C
Specific Gravity: 1.150 - 1.166 @ 20 Deg C
Purity: >95%
Appearance: Colourless liquid

Formula: C₉H₁₄O₆
MW: 218,21 g/mol
Boiling Pt: 258 °C (1013 hPa)
Melting Pt: –78 °C
Density: 1,1596 g/cm³ (20 °C)
Flash Pt: 138 °C (closed cup)
Storage Temperature: Ambient
MDL Number: MFCD00008716
CAS Number: 102-76-1
EINECS: 203-051-9
Merck Index: 12,09721
Melting point: 3 °C(lit.)
Boiling point: 258-260 °C(lit.)
Densit: 1.16 g/mL at 25 °C(lit.)
vapor density: 7.52 (vs air)
vapor pressure: 0.00248 mm Hg @ 250C
FEMA: 2007 | (TRI-)ACETIN
refractive index: n25/D 1.429-1.431(lit.)
Flash point: 300 °F
storage temp.: Sealed in dry,Room Temperature

solubility: Soluble in water, miscible with ethanol (96 per cent) and toluene.
form: Liquid
color: Clear colorless
Odor: Characteristic odour
Odor Type: fruity
explosive limit 1.05%, 189°F
Water Solubility: 64.0 g/L (20 ºC)
Merck: 14,9589
JECFA Number: 920
BRN: 1792353
Stability: Stable.
Incompatible with strong oxidizing agents.
InChIKey: URAYPUMNDPQOKB-UHFFFAOYSA-N
LogP: 0.25
FDA 21 CFR: 184.1901; 582.1901; 175.300; 175.320; 310.545
Substances Added to Food (formerly EAFUS): TRIACETIN (GLYCEROL TRIACETATE)
CAS DataBase Reference: 102-76-1(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: XHX3C3X673
NIST Chemistry Reference: 1,2,3-Propanetriol, triacetate(102-76-1)

EPA Substance Registry System: Glyceryl triacetate (102-76-1)
Molecular Weight: 218.20400
Exact Mass: 218.20
EC Number: 203-051-9
UNII: XHX3C3X673
ICSC Number: 1203
NSC Number: 757364|4796
DSSTox ID: DTXSID3026691
Color/Form: Colorless liquid|Colorless somewhat oily liquid
HScode: 2915390090
PSA: 78.90000
XLogP3: 0.2
Appearance: Liquid
Density: 1.1562 g/cm3 @ Temp: 25 °C
Melting Point: -78 °C
Boiling Point: 258-260 °C

Flash Point: 148ºC
Refractive Index: 1.429-1.433
Water Solubility: H2O: 64.0 g/L (20 ºC)
Storage Conditions: Keep container tightly closed in a dry and well-ventilated place.
Vapor Pressure: 0.0141mmHg at 25°C
Vapor Density: 7.52 (vs air)
Flammability characteristics: Lower flammable limit: 1.0% by volume at 373 deg F (189 deg C)
Explosive limit: 1.05%, 189°F
Odor: Slightly fatty odor
Taste: MILD, SWEET TASTE, BITTER ABOVE 0.05%
Henrys Law Constant: Henry's Law constant = 1.2X10-8 at 25 °C atm-cu m/mole at 25 °C (est)
Experimental Properties: Hydroxyl radical reaction rate constant = 8.5X10-12 cu cm/mole-sec at 25 °C (est)
Autoignition Temperature: 812 °F (433 °C)|433 °C
Flammable Limits: Lower flammable limit: 1.0% by volume at 373 °F (189 °C)



FIRST AID MEASURES of GLYCEROL TRIACETATE (TRIACETIN):
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of GLYCEROL TRIACETATE (TRIACETIN):
-Environmental precautions:
No special environmental precautions required.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of GLYCEROL TRIACETATE (TRIACETIN):
-Extinguishing media:
--Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
--Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of GLYCEROL TRIACETATE (TRIACETIN):
-Control parameters:
Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Use impervious clothing.
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
No special environmental precautions required.



HANDLING and STORAGE of GLYCEROL TRIACETATE (TRIACETIN):
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.



STABILITY and REACTIVITY of GLYCEROL TRIACETATE (TRIACETIN):
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
1,2,3-Propanetriol, triacetate
Acetin, tri-
Enzactin
Fungacetin
Glycerin triacetate
Glycerol triacetate
Glyceryl triacetate
Glyped
Kesscoflex TRA
Triacetine
Vanay
Kodaflex triacetin
Triacetyl glycerine
Triacetyl glycerin
Triacetyl glycerol
1,2,3-Propanetriol, 1,2,3-triacetate
NSC 4796
Glycerol, acetylated
2-(Acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate
GLYCEROL TRIACETATE
Triacetine
GLYCERYL TRIACETATE
triacetate
GLYCERIN TRIACETATE
Vanay
Enzactin
Fungacetin
1,2,3-TRIACETOXYPROPANE
2,3-diacetyloxypropyl acetate
1,2,3-Propanetriol Triacetate
1,2,3-Propanetriyl Triacetate
1,2,3-Triacetoxypropane
1,2,3-Triacetylglycerol
2-(Acetyloxy)-1-[(Acetyloxy)Methyl]Ethyl Acetate
Glycerin Triacetate
Glycerol Triacetate
Glyceryl Triacetate
1,2,3-Propanetriol,1,2,3-triacetate
Acetin,tri-
1,2,3-Propanetriol,triacetate
Enzactin
Fungacetin
Glycerol triacetate
Glyceryl triacetate
Kesscoflex TRA
Triacetin
Triacetine
Triacetylglycerin
Vanay
Glycerin triacetate
Glyped
1,2,3-Triacetoxypropane
Estol 1581
Ujostabil
Triacetylglycerol
Priacetin 1580
Priacetin 1581
NSC 4796
Edenor GTA
DRA 150
Speziol GTA
Kollisolv GTA
Triacetin 1584
Triacetain glycerol
Captex 500
Alphacure 920
DAR 150
Edenor GTA Kosher
106C
GTA
2,3-Diacetyloxypropyl acetate
1,3-Bis(acetyloxy)propan-2-yl acetate
DRA-150
2102168-03-4


GLYCEROL TRIPALMITATE

Glycerol tripalmitate is a solid, waxy substance at room temperature.
It is derived from the esterification of glycerol and palmitic acid.
Glycerol tripalmitate has a white or off-white color.
Glycerol tripalmitate is odorless.

CAS number: 555-44-2
EC number: 209-008-0



APPLICATIONS


Glycerol tripalmitate (tripalmitin) finds various applications in different industries.
Here are some of its key applications:

Food Industry:
Glycerol tripalmitate is used as a food additive, functioning as a thickening agent, emulsifier, and stabilizer.
Glycerol tripalmitate improves the texture and stability of food products like margarine, spreads, confectionery items, and baked goods.

Cosmetics and Personal Care:
Glycerol tripalmitate is utilized in skincare and cosmetic formulations as an emollient and moisturizing agent.
Glycerol tripalmitate helps to enhance the smoothness and softness of skin, making it an ingredient in creams, lotions, lip balms, and moisturizers.

Pharmaceuticals:
In the pharmaceutical industry, glycerol tripalmitate acts as a binder in tablet manufacturing.
Glycerol tripalmitate helps to hold the active ingredients together and ensure the integrity and stability of solid dosage forms.

Industrial Lubricants:
Due to its lubricating properties, glycerol tripalmitate is used as a lubricant in various industrial applications.
Glycerol tripalmitate can reduce friction and provide lubrication in machinery and equipment, particularly under high-temperature conditions.

Biofuel Production:
Glycerol tripalmitate can be used as a feedstock for biodiesel production.
Through transesterification, it can be converted into fatty acid methyl esters (FAME), which are commonly used as biofuels.

Research and Laboratory Use:
Glycerol tripalmitate is used in scientific research and laboratory settings as a reference compound or as a substrate for various enzymatic studies and lipid metabolism research.

Release Agent:
Glycerol tripalmitate can act as a release agent in various industries, including food processing and mold release applications.
Glycerol tripalmitate helps prevent sticking and adhesion of materials to surfaces, molds, or equipment during production processes.

Candle Manufacturing:
Due to its waxy nature and solid form, glycerol tripalmitate can be utilized in candle manufacturing.
Glycerol tripalmitate can serve as a component in candle formulations, contributing to the texture, hardness, and burn characteristics of the candles.

Carbon Paper Production:
Glycerol tripalmitate has been employed in the production of carbon paper, a type of paper used for creating duplicate copies of written or printed documents.
Glycerol tripalmitate acts as a coating on the paper surface, allowing the transfer of ink or graphite impressions to subsequent sheets.

Calibration Standards:
In analytical laboratories, glycerol tripalmitate can be used as a calibration standard for certain analytical techniques and instruments.
Glycerol tripalmitate serves as a reference compound for the identification and quantification of specific analytes or for verifying instrument performance.

Biomedical Research:
Glycerol tripalmitate has been studied for its potential applications in drug delivery systems and as a carrier for bioactive compounds.
Research is being conducted to explore its use in controlled-release formulations and nanostructured lipid carriers.

Energy Storage:
Triglycerides, including glycerol tripalmitate, have gained attention as a potential renewable energy storage medium.
They have been investigated as a source of stored energy, where the fatty acids can be converted back into usable energy through processes like biodiesel production or direct combustion.


Glycerol tripalmitate is used as a thickening agent, emulsifier, and stabilizer in the food industry.
Glycerol tripalmitate improves the texture and stability of food products like margarine, spreads, and baked goods.

In cosmetics and personal care products, glycerol tripalmitate acts as an emollient, enhancing the smoothness and softness of the skin.
Glycerol tripalmitate is commonly found in creams, lotions, lip balms, and moisturizers.
Glycerol tripalmitate serves as a binder in the pharmaceutical industry, ensuring the integrity and stability of tablets.
Glycerol tripalmitate is utilized in the production of solid dosage forms, such as tablets and capsules.

Glycerol tripalmitate acts as a release agent, preventing sticking and adhesion in food processing and mold release applications.
Glycerol tripalmitate finds use in candle manufacturing, contributing to the texture and burn characteristics of candles.
Glycerol tripalmitate can be employed in the production of carbon paper, facilitating the transfer of impressions to subsequent sheets.

In analytical laboratories, glycerol tripalmitate can be used as a calibration standard for certain analytical techniques and instruments.
Glycerol tripalmitate serves as a reference compound for identification and quantification purposes.
Glycerol tripalmitate has potential applications in drug delivery systems and as a carrier for bioactive compounds in biomedical research.

Glycerol tripalmitate has been studied for its use in controlled-release formulations and nanostructured lipid carriers.
Glycerol tripalmitate can act as a lubricant in various industrial applications, reducing friction and providing lubrication in machinery and equipment.
Glycerol tripalmitate is a potential feedstock for biodiesel production, contributing to renewable energy sources.
Glycerol tripalmitate is being explored for its use in energy storage, where the fatty acids can be converted back into usable energy.

Glycerol tripalmitate is used in the calibration of instruments and analytical techniques in scientific research.
Glycerol tripalmitate finds application in the production of specialty papers, including carbonless copy paper.

Glycerol tripalmitate is utilized in the formulation of coatings and paints, enhancing their texture and performance.
Glycerol tripalmitate is a component in the production of industrial adhesives and sealants.
Glycerol tripalmitate is used in the development of specialty chemicals, such as surfactants and lubricants.
Glycerol tripalmitate can be utilized as a carrier or encapsulating agent in the encapsulation of flavors, fragrances, or active ingredients.

Glycerol tripalmitate is employed in the production of lipsticks and other cosmetic products with desirable consistency and texture.
Glycerol tripalmitate is used in the manufacturing of soap, contributing to its texture and moisturizing properties.
Glycerol tripalmitate finds application in research and development, serving as a reference compound and substrate for lipid metabolism studies.



DESCRIPTION


Glycerol tripalmitate, also known as tripalmitin, is a chemical compound classified as a triglyceride.
Glycerol tripalmitate is composed of three fatty acid chains, specifically palmitic acid, esterified to a glycerol molecule.
Each of the three hydroxyl groups of glycerol is esterified with one palmitic acid molecule.

The chemical formula of glycerol tripalmitate is C₅₃H₁₀₀O₆, indicating its composition of 53 carbon atoms, 100 hydrogen atoms, and 6 oxygen atoms.
Glycerol tripalmitate is an example of a saturated fat due to the presence of palmitic acid, a saturated fatty acid.

Glycerol tripalmitate is a solid at room temperature and is insoluble in water.
Glycerol tripalmitate is commonly found in various natural sources, including animal fats and vegetable oils.
Glycerol tripalmitate serves as a form of energy storage in organisms and can be hydrolyzed by enzymes called lipases to release glycerol and three molecules of palmitic acid.

In industrial applications, glycerol tripalmitate is used as a thickening agent, emulsifier, and stabilizer in food products, cosmetics, and pharmaceuticals.
Its properties and functionality make it useful in enhancing texture, viscosity, and stability of formulations.

Glycerol tripalmitate is a solid, waxy substance at room temperature.
It is derived from the esterification of glycerol and palmitic acid.
Glycerol tripalmitate has a white or off-white color.
Glycerol tripalmitate is odorless.

Glycerol tripalmitate is insoluble in water.
Glycerol tripalmitate has a high melting point, typically around 63-65 degrees Celsius.

Glycerol tripalmitate is classified as a triglyceride due to its composition of three fatty acid chains.
Glycerol tripalmitate is primarily found in natural sources such as animal fats and vegetable oils.
Glycerol tripalmitate is considered a saturated fat due to the presence of palmitic acid.

Glycerol tripalmitate is a major component of many solid fats and oils.
Glycerol tripalmitate serves as an energy storage molecule in organisms.
Glycerol tripalmitate can be hydrolyzed by enzymes called lipases to release glycerol and three palmitic acid molecules.

Glycerol tripalmitate is used as an emollient in skincare and cosmetic products.
Glycerol tripalmitate helps to improve the texture and moisturizing properties of creams and lotions.
Glycerol tripalmitate is also utilized as a thickening agent in food products.

Glycerol tripalmitate can enhance the mouthfeel and stability of various food formulations.
Glycerol tripalmitate acts as a binder in the production of tablets in the pharmaceutical industry.

Glycerol tripalmitate helps to hold the active ingredients together in solid dosage forms.
Glycerol tripalmitate is non-toxic and considered safe for consumption and topical use.
Glycerol tripalmitate has a long shelf life and is resistant to oxidation.
Glycerol tripalmitate is often used as a lubricant in industrial applications.

Glycerol tripalmitate has low volatility, making it suitable for use in high-temperature processes.
Glycerol tripalmitate is biodegradable and environmentally friendly.
Glycerol tripalmitate has a wide range of applications, including in food, cosmetics, pharmaceuticals, and personal care products.
Glycerol tripalmitate is subject to quality control measures to ensure its purity and safety in various applications.



PROPERTIES


Physical Properties:

Physical State: Solid
Appearance: White or off-white color
Odor: Odorless
Melting Point: Approximately 63-65 degrees Celsius
Solubility: Insoluble in water
Solubility in Other Solvents: Soluble in organic solvents like ethanol, chloroform, and ether
Density: Varies depending on temperature and crystalline form


Chemical Properties:

Chemical Formula: C₅₃H₁₀₀O₆
Molecular Weight: Approximately 809.43 g/mol
Chemical Family: Triglyceride (ester of glycerol and palmitic acid)
Lipid Class: Neutral lipid
Fatty Acid Composition: Comprised of three palmitic acid molecules (C₁₆H₃₁COOH) esterified to a glycerol molecule
Saponification Value: The amount of alkali required to hydrolyze the compound to yield glycerol and fatty acids


Thermal and Stability Properties:

High Melting Point: Gives it a solid form at room temperature
Stability: Relatively stable under normal conditions, resistant to oxidation
Decomposition: Subject to thermal decomposition at elevated temperatures


Functional Properties:

Thickening Agent: Enhances viscosity and texture in food and cosmetic formulations
Emulsifier: Helps stabilize emulsions by promoting the dispersion of oil and water phases
Stabilizer: Improves the stability and shelf life of food and cosmetic products
Lubricating Properties: Exhibits lubricating characteristics, reducing friction in industrial applications
Moisturizing Agent: Provides hydration and moisturization in skincare and cosmetic products
Binding Agent: Holds together active ingredients in pharmaceutical tablet formulations



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air.
If breathing is difficult, provide oxygen if available and seek medical attention.


Skin Contact:

Remove contaminated clothing and wipe off excess glycerol tripalmitate from the skin.
Wash the affected area thoroughly with mild soap and water.
If irritation or redness develops, seek medical advice.
In case of extensive skin contact or if irritation persists, seek medical attention.


Eye Contact:

Rinse the eyes gently with lukewarm water for at least 15 minutes, keeping the eyelids open.
Remove contact lenses, if applicable, after the initial rinsing.
Seek immediate medical attention and bring the Safety Data Sheet or product container for reference.


Ingestion:

Rinse the mouth with water, but do not swallow any liquid.
Do not induce vomiting unless instructed to do so by medical professionals.
Seek immediate medical attention and bring the Safety Data Sheet or product container for reference.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear suitable protective clothing, including gloves and safety goggles, to prevent direct contact with the substance.
Ensure adequate ventilation in the working area to minimize inhalation of vapors or dust particles.

Avoid Ingestion and Inhalation:
Do not eat, drink, or smoke while handling glycerol tripalmitate.
Avoid inhalation of dust or vapors. Use appropriate respiratory protection if needed.

Avoid Skin and Eye Contact:
Prevent direct skin contact by wearing appropriate protective clothing, including gloves and long-sleeved clothing.
In case of accidental contact, promptly wash the affected area with soap and water.
Use safety goggles or a face shield to protect the eyes from potential splashes or contact.

Spill and Leak Response:
In the event of a spill or leak, contain the material and prevent it from spreading.
Absorb or collect spilled substance using suitable absorbent materials.
Dispose of the collected material in accordance with applicable regulations.


Storage:

Storage Temperature:
Store glycerol tripalmitate in a cool, dry, well-ventilated area.
Keep the substance away from direct sunlight and sources of heat or ignition.

Avoid Incompatible Materials:
Store glycerol tripalmitate away from strong oxidizing agents and incompatible materials.
Ensure proper segregation and storage to prevent chemical reactions or hazards.

Packaging:
Store the substance in tightly sealed, properly labeled containers or drums.
Use appropriate packaging materials to avoid leakage or damage during storage or transportation.

Fire Precautions:
Keep the substance away from open flames, sparks, or hot surfaces.
Implement suitable fire protection measures in the storage area, such as fire-resistant construction and extinguishing systems.

Specific Storage Recommendations:
Follow any specific storage recommendations provided by the manufacturer or stated in the Safety Data Sheet.
Comply with local regulations and guidelines for the safe storage of glycerol tripalmitate.



SYNONYMS


Glycerin tripalmitate
Tripalmitin
Trihexadecanoin
Glyceryl palmitate
Palmitin
Glyceryl trihexadecanoate
Triglyceride of palmitic acid
Glyceryl palmitic acid ester
Palmitic acid glyceride
Glycerol tris(palmitate)
Glyceryl tripalmitate
Trihexadecyl glycerol
Tristearin
Glyceryl tristearate
Stearin
Triglyceride of stearic acid
Glycerin tristearate
Glycerol tristearate
Triglycerol palmitostearate
Tri(palmitoyloxy)propane
Glyceryl palmitostearate
Palmitostearin
Glyceryl trin-hexadecanoate
Triglyceride of hexadecanoic acid
Hexadecanoyl glycerol
Glycerin trin-hexadecanoate
Glyceryl hexadecanoate
Glycerol trin-hexadecanoate
Triglycerol stearopalmitate
Glycerin tristearopalmitate
Glyceryl tristearopalmitate
Tristearo-palmitin
Glycerol trin-octadecanoate
Triglyceride of octadecanoic acid
Octadecanoyl glycerol
GLYCEROL TRISTEARATE

Glycerol tristearate is a solid, waxy substance at room temperature.
Glycerol tristearate is odorless and has a faint characteristic taste.
Glycerol tristearate has a white to off-white color.

CAS number: 555-43-1



APPLICATIONS


Glycerol tristearate, or tristearin, has various applications in different industries.
Here are some of its common applications:

Food Industry:
Glycerol tristearate is used as an emulsifier and stabilizer in food products.
Glycerol tristearate helps improve the texture and consistency of processed foods such as margarine, spreads, chocolate, confectionery, and baked goods.

Cosmetics and Personal Care:
Glycerol tristearate is utilized in cosmetics and personal care products for its emollient and moisturizing properties.
Glycerol tristearate can be found in creams, lotions, lipsticks, and other skincare formulations.

Pharmaceuticals:
Glycerol tristearate acts as a lubricant in the pharmaceutical industry, particularly in tablet formulations.
Glycerol tristearate aids in the easy release of tablets from molds and enhances their swallowability.

Industrial Lubricants:
Due to its lubricating properties, glycerol tristearate is used as a component in industrial lubricants and greases.
Glycerol tristearate helps reduce friction and wear between moving parts in machinery and equipment.

Candle Making:
Glycerol tristearate is commonly used in the production of candles.
Glycerol tristearate serves as a key ingredient in candle wax formulations, providing structure, stability, and a slow-burning characteristic.

Rubber and Plastics:
Glycerol tristearate acts as a release agent in the manufacturing of rubber and plastic products.
Glycerol tristearate prevents sticking of the material to molds during the production process.

Textile Industry:
Glycerol tristearate finds application in the textile industry as a softening agent and lubricant for fabrics.
Glycerol tristearate can improve the hand feel and flexibility of textiles, making them more comfortable to wear.

Metal Processing:
Glycerol tristearate is employed in metalworking processes as a lubricant and anti-weld agent.
Glycerol tristearate helps reduce friction during machining and prevents metal particles from sticking to tools and surfaces.


Glycerol tristearate is commonly used as an emulsifier and stabilizer in the food industry.
Glycerol tristearate helps maintain the texture and consistency of margarine and spreads.
Glycerol tristearate is used in chocolate production to improve viscosity and prevent fat bloom.

Glycerol tristearate serves as a vital ingredient in confectionery items like candies and chocolate coatings.
Glycerol tristearate is utilized in bakery products to enhance dough handling and improve crumb texture.

Glycerol tristearate is a key component in the formulation of lipstick, providing structure and texture.
Glycerol tristearate acts as a moisturizing agent in creams and lotions, helping to nourish the skin.
Glycerol tristearate is used in the production of soaps and cleansing bars to create a creamy lather.
Glycerol tristearate is employed in the pharmaceutical industry as a lubricant in tablet manufacturing.

Glycerol tristearate aids in the smooth release of tablets from molds and prevents sticking.
Glycerol tristearate finds application in the production of candles, providing a slow-burning and solid wax base.

Glycerol tristearate is used as a release agent in the manufacturing of rubber and plastic products.
Glycerol tristearate helps prevent adhesion and sticking of the material to molds and equipment.
Glycerol tristearate serves as an emollient in cosmetic formulations, providing a soft and smooth texture.

Glycerol tristearate is used in haircare products to improve manageability and add shine to the hair.
Glycerol tristearate finds application in the formulation of sunscreen products, contributing to their water resistance.

Glycerol tristearate is used in the production of industrial lubricants, reducing friction and wear in machinery.
Glycerol tristearate serves as a thickening agent in certain paint and coating formulations, improving their consistency.

Glycerol tristearate finds application in the textile industry as a softening agent for fabrics.
Glycerol tristearate is used in metalworking processes as a lubricant and anti-weld agent.
Glycerol tristearate finds application in the production of paper and paperboard, enhancing their printability and surface properties.
Glycerol tristearate is used in the formulation of adhesives and sealants, providing viscosity and stability.

Glycerol tristearate is employed in the production of plasticizers, improving the flexibility and workability of plastic materials.
Glycerol tristearate is used in the manufacturing of wax-based polishes for furniture and floors.
Glycerol tristearate finds application in the leather industry for conditioning and softening leather products.

Glycerol tristearate is utilized in the production of chewing gum to improve its texture and mouthfeel.
Glycerol tristearate is used in the formulation of lip balms and lip care products for its moisturizing properties.

Glycerol tristearate is employed as a binder in the production of pressed powders and cosmetic compacts.
Glycerol tristearate finds application in the manufacture of cold creams and ointments, providing emollient and occlusive properties.
Glycerol tristearate is used in the production of adhesives for improved tack and bond strength.

Glycerol tristearate serves as a plasticizer in the rubber industry, enhancing the flexibility and elasticity of rubber products.
Glycerol tristearate finds application in the production of gel capsules, enabling easy swallowing of medications and supplements.
Glycerol tristearate is used in the formulation of shaving creams and foams to provide lubrication and a smooth shaving experience.

Glycerol tristearate is employed in the production of printing inks for its viscosity and pigment dispersion properties.
Glycerol tristearate finds application in the textile printing industry as an auxiliary agent to improve color fastness and print quality.
Glycerol tristearate is used in the manufacture of wax-based crayons and colored pencils for their smooth application.

Glycerol tristearate serves as a release agent in the production of molded plastic products, ensuring easy demolding and preventing surface defects.
Glycerol tristearate finds application in the production of inkjet inks for its compatibility with dye and pigment dispersion.
Glycerol tristearate is used in the formulation of metal coatings to provide corrosion resistance and improve adhesion.
Glycerol tristearate is employed in the production of dietary supplements as a carrier for fat-soluble vitamins and nutrients.

Glycerol tristearate finds application in the formulation of polishes for shoes and leather goods, providing shine and protection.
Glycerol tristearate is used in the production of wax-based modeling compounds for arts and crafts.
Glycerol tristearate serves as a lubricant in wire and cable manufacturing, facilitating smooth wire drawing and reducing friction.
Glycerol tristearate is employed in the production of molded chocolates and pralines for their glossy appearance and snap texture.

Glycerol tristearate finds application in the production of solid oral dosage forms, such as sustained-release tablets and capsules.
Glycerol tristearate is used in the production of animal feeds as an energy source and binder for pellets.

Glycerol tristearate serves as a plasticizer in PVC (polyvinyl chloride) formulations, improving flexibility and processability.
Glycerol tristearate finds application in the production of thermal transfer ribbons for printing on labels and packaging materials.

Glycerol tristearate is used in the formulation of face masks and skincare products for its moisturizing and nourishing properties.
Glycerol tristearate is employed in the production of specialty waxes, such as investment casting waxes and dental waxes.



DESCRIPTION


Glycerol tristearate, also known as tristearin, is a chemical compound belonging to the ester group.
Its chemical formula is C57H110O6, and its systematic name is 1,2,3-trihydroxypropane tristearate.
Glycerol tristearate is formed by esterification of glycerol (a triol) with stearic acid (a long-chain saturated fatty acid).

In simpler terms, glycerol tristearate consists of three stearic acid molecules chemically linked to a glycerol molecule.
The stearic acid molecules provide the fatty nature to the compound, while the glycerol molecule acts as a backbone.
This combination results in a solid, waxy substance at room temperature.

Glycerol tristearate is a solid, waxy substance at room temperature.
Glycerol tristearate is odorless and has a faint characteristic taste.
Glycerol tristearate has a white to off-white color.

Glycerol tristearate is insoluble in water.
Glycerol tristearate is soluble in organic solvents such as ethanol and chloroform.

Glycerol tristearate has a high melting point, typically around 68-70°C.
Glycerol tristearate is a triglyceride composed of three stearic acid molecules and one glycerol molecule.

Glycerol tristearate is derived from natural sources such as animal fats and vegetable oils.
Glycerol tristearate is commonly found in various food products as a food additive and emulsifier.

Glycerol tristearate is used in the cosmetic industry for its emollient and moisturizing properties.
Glycerol tristearate is also utilized in the pharmaceutical industry as a lubricant in tablet formulations.
Glycerol tristearate has excellent stability and resistance to oxidation.
Glycerol tristearate exhibits good heat resistance and is often used in high-temperature applications.
Glycerol tristearate is a common ingredient in the production of candles and other wax-based products.

Glycerol tristearate is used as a release agent in the manufacturing of rubber and plastics.
Glycerol tristearate acts as a thickening agent in certain formulations, such as creams and lotions.

Glycerol tristearate can enhance the texture and mouthfeel of food products, providing a smooth and creamy sensation.
Glycerol tristearate is employed as a binder in the production of pressed powders and cosmetics.
Glycerol tristearate is biodegradable and environmentally friendly.

Glycerol tristearate is considered safe for use in various applications, including food and personal care products.
Glycerol tristearate has low toxicity and is not known to cause significant health risks.
Glycerol tristearate has good compatibility with other ingredients, making it versatile in formulation.

Glycerol tristearate has a long shelf life and can withstand storage and transportation conditions.
Glycerol tristearate is a valuable ingredient in the production of lubricants and greases.
Glycerol tristearate plays a crucial role in numerous industries, contributing to the functionality and quality of various products.



PROPERTIES


Chemical Formula: C57H110O6
Molecular Weight: 891.50 g/mol
Appearance: White to off-white solid
Odor: Odorless
Melting Point: Approximately 70-75°C (158-167°F)
Boiling Point: Decomposes before boiling
Density: 0.86 g/cm3
Solubility: Insoluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
Refractive Index: 1.438 (at 20°C)
Flash Point: >200°C (>392°F)
Vapor Pressure: Negligible
Viscosity: High viscosity in molten state
pH: Neutral
Stability: Stable under normal conditions
Flammability: Non-flammable
Autoignition Temperature: Not applicable
Hydrogen Bonding: Exhibits hydrogen bonding due to the presence of hydroxyl groups
Emulsifying Properties: Acts as an emulsifier, aiding in the mixing of immiscible substances
Lubricating Properties: Provides lubrication and reduces friction between surfaces
Solidification Behavior: Forms a solid with a crystalline structure upon cooling



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air and ensure they are in a well-ventilated area.
If breathing difficulties persist, seek medical attention immediately.
Provide artificial respiration if necessary.


Skin Contact:

Remove any contaminated clothing and immediately rinse the affected area with plenty of water.
Gently wash the skin with mild soap and water.
If irritation occurs or persists, seek medical advice.
Apply a suitable moisturizer or skin cream to help restore skin moisture.


Eye Contact:

Flush the eyes gently with water for at least 15 minutes, ensuring to remove any contact lenses if present and easily removable.
Seek immediate medical attention and bring the product label or safety data sheet for reference.
Avoid rubbing the eyes to prevent further irritation or damage.


Ingestion:

Rinse the mouth thoroughly with water and drink plenty of water to dilute the product.
Do not induce vomiting unless instructed to do so by medical professionals.
Seek immediate medical attention and provide the medical personnel with detailed information about the product.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate protective clothing, including gloves, safety goggles, and a lab coat or protective suit, to minimize exposure.
Use respiratory protection, such as a dust mask or respirator, if handling the product in powdered or aerosol form.

Ventilation:
Ensure good ventilation in the working area to prevent the buildup of vapors or dust concentrations.
If necessary, use local exhaust ventilation or wear respiratory protection to control exposure levels.

Avoiding Contact:
Avoid direct contact with the skin, eyes, and clothing.
Handle the product with clean, dry tools or equipment to prevent contamination.

Storage and Handling:
Store Glycerol tristearate in a tightly sealed container in a cool, dry, and well-ventilated area.
Keep away from heat sources, open flames, sparks, and direct sunlight.
Prevent the entry of moisture or water into the storage container to maintain product quality.
Follow all relevant safety guidelines and regulations when handling the substance.


Storage:

Temperature:
Store Glycerol tristearate at room temperature, preferably between 15°C and 30°C (59°F and 86°F).

Container:
Use suitable containers, such as tightly sealed plastic or metal containers, to store the product.
Ensure the containers are labeled correctly with the product name, batch number, and hazard information.

Separation:
Store Glycerol tristearate away from incompatible substances, such as strong oxidizing agents or acids, to prevent chemical reactions.

Handling Precautions:
Avoid dropping or mishandling containers to prevent spills or breakages.
Use appropriate equipment, such as drum pumps or scoops, to transfer the product and minimize the risk of exposure.

Fire Safety:
Keep Glycerol tristearate away from potential ignition sources and flammable materials.
In the event of a fire involving the substance, use suitable extinguishing media, such as carbon dioxide or dry chemical powder.



SYNONYMS


Tristearin
Glyceryl tristearate
Glycerin tristearate
Glyceryl tristearin
1,2,3-Propanetriol tristearate
Glycerol tristearin
Glycerol tristearyl ester
Triglyceride tristearin
Triglycerol tristearate
Tri(stearoyl) glycerol
Glycerin trioctadecanoate
Triglyceride of stearic acid
Glycerol trioctadecanoate
Triglyceride 50 C18:0
Glycerin trioctadecyl ester
Glyceryl tristearyl ether
Glycerin trioctadecyl ether
Triglyceride stearic acid ester
Glycerol trioctadecyl ester
Triglycerol trioctadecanoate
Glycerol trioctadecyl ether
Tristearate of glycerol
Glycerol ester of stearic acid
Glyceryl trioctadecanoate
Triglyceride of octadecanoic acid
Tri(stearinyl) glycerol
Triglyceride C18:0
Glyceryl tristearylate
Glycerol trioctadecanoic ester
Triglycerol trioctadecyl ester
Glycerol trioctadecylate
Tristearoylglycerol
Stearic acid triglyceride
Glycerin tristearylate
Glyceryl tristearate ester
Triglyceride of stearin
Glycerol trioctadecanoate ester
Tri(stearoyloxy) glycerol
Glycerol trioctadecyl stearate
Triglycerol trioctadecyl stearate
Glyceryl trioctadecanoate ester
Tristearin glyceride
Glycerin trioctadecanoate ester
Tri(stearoyloxy)glycerol
Glycerol trioctadecyl stearate ester
Triglycerol trioctadecyl stearate ester
Glycerol tristearate triglyceride
Tristearin triester
Glycerin trioctadecyl stearate triglyceride
Tri(stearoyloxy) glyceryl ester

GLYCERYL DIACETATE (DIACETIN)
DESCRIPTION:
Glyceryl diacetate (Diacetin) is a food additive with the E number E1517.
This diglyceride is more generally known as diacetin.
Glyceryl diacetate (Diacetin) is the diester of glycerol and acetylating agents, such as acetic acid and acetic anhydride.

CAS Number, 25395-31-7
EC Number, 246-941-2


SYNONYMS OF GLYCERYL DIACETATE (DIACETIN):
Diacetin; Glycerol diacetate, 1,2,3-Propanetriol, 1,2-diacetate; 2-(Acetyloxy)-1-(hydroxymethyl)ethyl acetate; 1,2-Diacetin; Acetin, 1,2-di-; Acetic acid, diglyceride; (Hydroxymethyl)ethylene acetate; 1,2-Diacetylglycerol; 2,3-Diacetin; 2,3-Diacetoxypropan-1-ol; NSC 2348, 1,2,3-Propanetriol,diacetate;Acetin,di-;Diacetin;Glycerol diacetate;Glyceryl diacetate;Diacetylglycerol;Glycerine diacetate;Glycerin diacetate;Estol 1583;Estol 1582;Diacetain glycerol;1300-63-6;29860-16-0;1202865-19-7, Glycerol Diacetate; 1,2,3-Propanetriol, Diacetate;
Diacetylglycerol; Glycerin diacetate; Glycerine Diacetate; Glyceryl Diacetate; Glycerol 1,3-diacetate; 2-(Acetyloxy)-1-(hydroxymethyl)ethyl acetate; 1,3-Di(acetato) de glicerol (Spanish); 1,3-di(acétate) de glycerol (French); GLYCERYL DIACETATE;Glycerin diacetate;GLYCEROL DIACETATE;Glycerol 1,3-diacetate;3-Hydroxypropane-1,2-diyl diacetate;2-(Acetyloxy)-1-(hydroxymethyl)ethyl acetate;di-aceti;DIACETIN;Carset 555;Carset 533



Glycerine (glycerin, glycerol, or 1,2,3-propanetriol) is the simplest trihedric alcohol.
Pure glycerine, with a specific gravity of 1.26, is a colorless, odorless, sweet, viscous liquid melting at 17.8 C boiling at 290 C.
Glyceryl diacetate (Diacetin) decomposes at boiling point and produce corrosive fumes of acrolein.

Glyceryl diacetate (Diacetin) is miscible in water and forms a solution in any proportion.
Glyceryl diacetate (Diacetin) is also soluble alcohol but only partially soluble in common organic solvents such as ether and ethyl acetate.
Glyceryl diacetate (Diacetin) resists freezing.

Glyceryl diacetate (Diacetin) is hygroscopic, which favors as a humectant to retain moisture in cosmetics.
Glyceryl diacetate (Diacetin) reacts violently with acetic anhydrides in the presence of a catalyst.
Glyceryl diacetate (Diacetin) is obtained as a byproduct when fats and oils are hydrolyzed to yield fatty acids or soaps.

Glyceryl diacetate (Diacetin) is also commercially synthesized from propylene (Dow Chemical).
Glyceryl diacetate (Diacetin) can also be obtained based on a proprietary fermentation processing.
Glycerol is widely used; as a solvent, food additive, sweetening agent and emollient and emulcent with magnesium sulphate used in the treatment of septic wounds and boils; in the manufacture of alkyd resin, cellophane, ester gums, plasticizer, dynamite, nitroglycerine, cosmetics, liquid soap, perfume and toothpaste (good solubility and taste give glycerine an edge on sorbitol in toothpastes, which are estimated to make up almost one-third of glycerine's market in personal care products); as a component of antifreeze mixtures; to keep fabrics pliable, to preserve printing on cotton, to keep frost from windshields; as a source of nutrients for fermentation cultures in the production of antibiotics; as a preservative in some pharmaceutical and biological preparations and in non-alcoholic extracts and tinctures.

Glyceryl diacetate (Diacetin) has many other applications.









Glyceryl diacetate (Diacetin) is Clear, colourless, hygroscopic, somewhat oily liquid with a slight, fatty odour, consisting predominantly of a mixture of the 1,2- and 1,3-diacetates of glycerol, with minor amounts of the mono- and tri-esters

Glyceryl diacetate (Diacetin) is a colorless, viscous and odorless liquid with a high boiling point.
Glycerol diacetate (Diacetin) is typically a mixture of two isomers, 1,2-glyceryl diacetate and 1,3-glyceryl diacetate.

USES OF GLYCEROL DIACETATE (DIACETIN):
Glycerol diacetate (Diacetin) is Used in the food industry, it gives dishes a buttery taste.
Diacetin is also used as a solvent, plasticizer, and softening agent.

Diacetin has been used to design and evaluate gliclazide push-pull osmotic pump (PPOP) coated with aqueous colloidal polymer dispersions
Diacetin is used as a solvent, plasticizer, and softening agent.

Glycerol diacetate (Diacetin), triacetate ester of glycerol, is a clear, combustible and oily liquid with a bitter taste and a fatty odor.
Glycerol diacetate (Diacetin) is slightly soluble in water but soluble in alcohol and ether.

Glycerol diacetate (Diacetin) has properties of both glycerol and acetate.
Diacetin (CAS RN: 25395-31-7) and nonoacetin (CAS RN: 26446-35-5) are glycerin diacetate and glycerin monoacetate respectively.

Glycerol diacetate (Diacetin) is found in some food like butter as it is used as a food additive for the solvency of flavourings for the function of humectant.
Glycerol diacetate (Diacetin) is used in perfumery and cosmetics for these applications.

Glycerol diacetate (Diacetin) is used as an antifungal agent in external medicine for topical treatment of superficial fungal infections of the skin.
Glycerol diacetate (Diacetin) is applied to cigarette filter as a plasticizer.
Glycerol diacetate (Diacetin) is used as a gelatinizing agent in explosives.


CHEMICAL AND PHYSICAL PROPERTIES OF GLYCEROL DIACETATE (DIACETIN):
Chemical formula, C7H12O5
Molar mass, 176.168 g•mol−1
Melting point, −30 °C (−22 °F; 243 K)
Boiling point, 280 °C (536 °F; 553 K)
CAS Number, 25395-31-7 (mixture)
102-62-5 (1,2)
105-70-4 (1,3)
3D model (JSmol), Interactive image
ChemSpider, 59412 (1,2)60286 (1,3)
ECHA InfoCard, 100.042.659
EC Number, 246-941-2
E number, E1517
grade
technical grade
Quality Level
100
vapor density
6.1 (vs air)
vapor pressure
form
liquid
concentration
50%
refractive index
n20/D 1.440 (lit.)
solubility
alcohol: soluble(lit.)
benzene: soluble(lit.)
carbon disulfide: insoluble (practically)(lit.)
diethyl ether: soluble(lit.)
water: soluble(lit.)

density
1.17 g/mL at 25 °C (lit.)
Molecular Weight:
176.17
Exact Mass:
176.068466
HScode:
2918199090
PSA:
72.83000
XLogP3:
-0.52650
Appearance:
absorption near colorless, transparent oily liquid
Density:
1.2±0.1 g/cm3
Melting Point:
-30 °C
Boiling Point:
259 °C
Flash Point:
90.7±11.7 °C
Refractive Index:
1.444
Water Solubility:
Soluble in water, alcohol, ether, benzene
Storage Conditions:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Vapor Pressure:
Vapor Density:
6.1 (vs air)
PHYSICAL STATE, clear oily liquid
MELTING POINT, -30 C
BOILING POINT, 259 C
SPECIFIC GRAVITY, 1.18 - 1.195
SOLUBILITY IN WATER, slightly soluble (soluble alcohol; slightly soluble in ether, carbon disulfide; insoluble in benzene)
NFPA RATINGS, Health: 1 Flammability: 1 Reactivity: 0
STABILITY, Stable under ordinary conditions
Density, 1.19
Boiling Point, 250°C to 280°C (decomposition)
Flash Point, 141°C (285°F)
Refractive Index, 1.444
Quantity, 250 g
Beilstein, 1706903
Sensitivity, Hygroscopic
Merck Index, 14,2961
Solubility Information, Fully miscible in water.
Formula Weight, 176.17
Percent Purity, ≈50%
Grade, Technical
Assay, remainder triacetin and monoacetin
Chemical Name or Material, Diacetin, mixed isomers
Physical State :
Liquid
Storage :
Desiccate at room temperature
Density :
1.17 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.440 (lit.)
-30 °C
Boiling point:
280 °C
Density
1.17 g/mL at 25 °C (lit.)
vapor density
6.1 (vs air)
vapor pressure
refractive index
n20/D
Melting point, -30 °C
Boiling point, 280 °C
Density, 1.17 g/mL at 25 °C (lit.)
vapor density, 6.1 (vs air)
vapor pressure, refractive index, n20/D 1.440(lit.)
Flash point, >230 °F
storage temp., Inert atmosphere,Room Temperature
solubility, alcohol: soluble(lit.)
form, Liquid
color, Clear colorless
PH, 5-6 (50g/l, H2O, 20℃)
Odor, at 100.00 %. very mild alcoholic
Odor Type, alcoholic
Water Solubility, Soluble in water, alcohol, ether, benzene
Sensitive, Hygroscopic
Merck, 14,2961
BRN, 1706903
LogP, -0.640
Indirect Additives used in Food Contact Substances, GLYCEROL DIACTATE
FDA 21 CFR, 177.1200
CAS DataBase Reference, 25395-31-7(CAS DataBase Reference)
EWG's Food Scores, 1
FDA UNII, GJ0544W99Q
NIST Chemistry Reference, 1,2,3-Propanetriol, diacetate(25395-31-7)
EPA Substance Registry System, 1,2,3-Propanetriol, diacetate (25395-31-7)



SAFETY INFORMATION ABOUT GLYCERYL DIACETATE (DIACETIN):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
GLYCERYL DIACETATE (DIACETIN)
DESCRIPTION:

Glyceryl Diacetate (Diacetin) is a food additive with the E number E1517.
Glyceryl Diacetate (Diacetin) is more generally known as diacetin.
Glyceryl Diacetate (Diacetin) is the diester of glycerol and acetylating agents, such as acetic acid and acetic anhydride.

CAS Number, 25395-31-7
EC Number, 246-941-2
Linear Formula:: (CH3COOCH2)2CHOH


SYNONYMS OF GLYCERYL DIACETATE (DIACETIN):
Glycerol diacetate 1,2,3-Propanetriol Diacetate, Diacetin, Glycerol Diacetate, E1517,glyceryl diacetate, 1,2-diacetin, glycerol diacetate, 1,2,3-propanetriol, diacetate, 3-hydroxypropane-1,2-diyl diacetate, glycerol 1,2-diacetate, 1,2-diacylglycerol, 2,3-diacetin, 1,2-diacetylglycerol, acetin, di,102-62-5,1,2,3-Propanetriol, diacetate,3-Hydroxypropane-1,2-diyl diacetate,1,2-Diacetin,1,2-Diacetylglycerol,Glycerol diacetate,1,2-diacylglycerol,3-DiacetinGlycerol 1,2-diacetate,Glyceryl diacetate,(2-acetyloxy-3-hydroxypropyl) acetate,Acetin, di-,(Hydroxymethyl)ethylene acetate,Acetin, 1,2-di-,1,2,3-Propanetriol, 1,2-diacetate,2,3-Diacetoxypropan-1-ol,acid, diglyceride,NSC 2348,glyceryl 1,2-diacetate,1-(acetyloxy)-3-hydroxypropan-2-yl acetate,NSC-2348,Glycerin diacetate,9W955270ZW,Glycerine diacetate,Estol 1582,Estol 1583,EINECS 246-941-2,1775840,UNII-GJ0544W99Q,AI3-00676,CCRIS 9354,CCRIS 9462,UNII-9W955270ZW,Diacetyl glycerine,Acetin,2-di-,2-(Acetyloxy)-1-(hydroxymethyl)ethyl acetate,DL-1,2-DIACETIN,WLN: 1VOY1Q1OV1,SCHEMBL77521,3-02-00-00331 (Beilstein Handbook Reference),1,2-Diacetin (~90%),1,2-DIACETIN, DL,DAG 4:0,DTXSID70883105,NSC2348,(+/-)-Glycerol 1,2-diacetate,CHEBI:173246,GJ0544W99Q,1,3-Propanetriol, 1,2-diacetate,3-Hydroxypropane-1,2-diyldiacetate,AKOS006273209,Diacetin (Mixture) (Technical Grade),1,2-DIACETIN, (+/-)-,(1-acetyloxy-3-hydroxypropan-2-yl)acetate,CS-0236630,FT-0624585,NS00013555,EN300-1720881,A877596,Q24300357,Z1198148277,2-(Acetyloxy)-1-(hydroxymethyl)ethyl acetate, AldrichCPR,101364-64-1

Glyceryl Diacetate (Diacetin) is widely used as plasticizer.
Glyceryl Diacetate (Diacetin) has been used to design and evaluate gliclazide push-pull osmotic pump (PPOP) coated with aqueous colloidal polymer dispersions.


Glyceryl Diacetate (Diacetin) is a colorless, viscous and odorless liquid with a high boiling point.
Glycerol diacetate is typically a mixture of two isomers, 1,2-glyceryl diacetate and 1,3-glyceryl diacetate.



APPLICATIONS OF GLYCERYL DIACETATE (DIACETIN):
Glyceryl Diacetate (Diacetin) has been used to design and evaluate gliclazide push-pull osmotic pump (PPOP) coated with aqueous colloidal polymer dispersions

Clear, colourless, hygroscopic, somewhat oily liquid with a slight, fatty odour, consisting predominantly of a mixture of the 1,2- and 1,3-diacetates of glycerol, with minor amounts of the mono- and tri-esters

A diglyceride resulting from the formal condensation of any two of the hydroxy groups of glycerol with the carboxy groups of two molecules of acetic acid (either R1 = H and R2 = Ac, or R1 = Ac and R2 = H).
Glyceryl Diacetate (Diacetin) is widely used as plasticizer.

Glyceryl Diacetate (Diacetin) has been used to design and evaluate gliclazide push-pull osmotic pump (PPOP) coated with aqueous colloidal polymer dispersions.
Food additive as a solvent for other additives, especially flavors.
Glyceryl Diacetate (Diacetin) is obtained from acetic acid and glycerol.

Glyceryl Diacetate (Diacetin) is a high-quality, clear ester liquid used as a solvent and carrier.
Glyceryl Diacetate (Diacetin) is used in chemical manufacturing and other food applications.


Glyceryl Diacetate (Diacetin), triacetate ester of glycerol, is a clear, combustible and oily liquid with a bitter taste and a fatty odor.
Glyceryl Diacetate (Diacetin) is slightly soluble in water but soluble in alcohol and ether.

Glyceryl Diacetate (Diacetin) has properties of both glycerol and acetate.
Glyceryl Diacetate (Diacetin) (CAS RN: 25395-31-7) and nonoacetin (CAS RN: 26446-35-5) are glycerin diacetate and glycerin monoacetate respectively.
Glyceryl Diacetate (Diacetin) is found in some food like butter as it is used as a food additive for the solvency of flavourings for the function of humectant.

Glyceryl Diacetate (Diacetin) is used in perfumery and cosmetics for these applications.
Glyceryl Diacetate (Diacetin) is used as an antifungal agent in external medicine for topical treatment of superficial fungal infections of the skin.
Glyceryl Diacetate (Diacetin) is applied to cigarette filter as a plasticizer.
Glyceryl Diacetate (Diacetin) is used as a gelatinizing agent in explosives.


Glyceryl Diacetate (Diacetin) (glycerin, glycerol, or 1,2,3-propanetriol) is the simplest trihedric alcohol.
Pure glycerine, with a specific gravity of 1.26, is a colorless, odorless, sweet, viscous liquid melting at 17.8 C boiling at 290 C.
Glyceryl Diacetate (Diacetin) decomposes at boiling point and produce corrosive fumes of acrolein.

Glyceryl Diacetate (Diacetin) is miscible in water and forms a solution in any proportion.
Glyceryl Diacetate (Diacetin) is also soluble alcohol but only partially soluble in common organic solvents such as ether and ethyl acetate.
Glyceryl Diacetate (Diacetin) resists freezing.

Glyceryl Diacetate (Diacetin) is hygroscopic, which favors as a humectant to retain moisture in cosmetics.
Glyceryl Diacetate (Diacetin) reacts violently with acetic anhydrides in the presence of a catalyst.
Glyceryl Diacetate (Diacetin) is obtained as a byproduct when fats and oils are hydrolyzed to yield fatty acids or soaps.

Glyceryl Diacetate (Diacetin) is also commercially synthesized from propylene (Dow Chemical).
Glyceryl Diacetate (Diacetin) can also be obtained based on a proprietary fermentation processing.
Glyceryl Diacetate (Diacetin) is widely used; as a solvent, food additive, sweetening agent and emollient and emulcent with magnesium sulphate used in the treatment of septic wounds and boils; in the manufacture of alkyd resin, cellophane, ester gums, plasticizer, dynamite, nitroglycerine, cosmetics, liquid soap, perfume and toothpaste (good solubility and taste give glycerine an edge on sorbitol in toothpastes, which are estimated to make up almost one-third of glycerine's market in personal care products); as a component of antifreeze mixtures; to keep fabrics pliable, to preserve printing on cotton, to keep frost from windshields; as a source of nutrients for fermentation cultures in the production of antibiotics; as a preservative in some pharmaceutical and biological preparations and in non-alcoholic extracts and tinctures. It has many other applications.


CHEMICAL AND PHYSICAL PROPERTIES OF GLYCERYL DIACETATE (DIACETIN)
Chemical formula, C7H12O5
Molar mass, 176.168 g•mol−1
Melting point, −30 °C (−22 °F; 243 K)
Boiling point, 280 °C (536 °F; 553 K)
CAS Number:
25395-31-7
Molecular Weight:
176.17
EC Number:
246-941-2
E No., E 1517
Chemical Family
Esters,
Glycerol Esters & Derivatives
Chemical Name
Glyceryl Diacetate
Ingredient Name
Glyceryl Diacetate
Base Chemicals Functions
Solvent
Food Ingredients Functions
Carrier,
Solvent
Technologies
Base Chemicals & Intermediates,
Food Ingredients
Product Families
Food Ingredients — Functional Additives
Carriers & Bulking Aids
Base Chemicals & Intermediates — Solvents
Esters
Color, max. 15, HU
Acidity (as acetic acid), max. 0.03, %
Saponification Value, 605 - 635
Water Content, max. 0.2
Specific Gravity (at 20/20°C), 1.175 - 1.195
Molecular Weight
176.17 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
XLogP3
-0.3
Computed by XLogP3 3.0 (PubChem release 2021.10.14)
Hydrogen Bond Donor Count
1
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Hydrogen Bond Acceptor Count
5
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Rotatable Bond Count
6
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Exact Mass
176.06847348 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Monoisotopic Mass
176.06847348 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Topological Polar Surface Area
72.8Ų
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Heavy Atom Count
12
Computed by PubChem
Formal Charge
0
Computed by PubChem
Complexity
165
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Isotope Atom Count
0
Computed by PubChem
Defined Atom Stereocenter Count
0
Computed by PubChem
Undefined Atom Stereocenter Count
1
Computed by PubChem
Defined Bond Stereocenter Count
0
Computed by PubChem
Undefined Bond Stereocenter Count
0
Computed by PubChem
Covalently-Bonded Unit Count
1
Computed by PubChem
Compound Is Canonicalized
Yes
grade
technical grade
Quality Level
100
vapor density
6.1 (vs air)
vapor pressure
<1 mmHg ( 20 °C)
form
liquid
concentration
50%
refractive index
n20/D 1.440 (lit.)
solubility
alcohol: soluble(lit.)
benzene: soluble(lit.)
carbon disulfide: insoluble (practically)(lit.)
diethyl ether: soluble(lit.)
water: soluble(lit.)

density
1.17 g/mL at 25 °C (lit.)
SMILES string
CC(=O)OCC(O)COC(C)=O.CC(=O)OCC(CO)OC(C)=O
InChI
1S/2C7H12O5/c1-5(8)11-3-7(10)4-12-6(2)9;1-5(9)11-4-7(3-8)12-6(2)10/h7,10H,3-4H2,1-2H3;7-8H,3-4H2,1-2H3
InChI key
TWSUHSVPDUPKDH-UHFFFAOYSA-N
Composition, C7H12O5
CAS, 25395-31-7
Melting Point, -30 C
Density, 1.184 g/ml
Molecular Weight, mol. wt. = 176.17
Refractive Index, 1.44
Boiling Point, 259 C
CAS, 25395-31-7
Boiling Point, 250°C to 280°C (decomposition)
Molecular Formula, C7H12O5
MDL Number, MFCD00008717
Beilstein, 1706903
Merck Index, 14,2961
Solubility Information, Fully miscible in water.
Percent Purity, ≈50%
Chemical Name or Material, Diacetin, mixed isomers
Flash Point, 141°C (285°F)
Refractive Index, 1.444
Quantity, 250 g
Sensitivity, Hygroscopic
Synonym, glyceryl diacetate, 1,2-diacetin, glycerol diacetate, 1,2,3-propanetriol, diacetate, 3-hydroxypropane-1,2-diyl diacetate, glycerol 1,2-diacetate, 1,2-diacylglycerol, 2,3-diacetin, 1,2-diacetylglycerol, acetin, di
Formula Weight, 176.17
Grade, Technical
Assay, remainder triacetin and monoacetin
Melting point, -30 °C
Boiling point, 280 °C
Density, 1.17 g/mL at 25 °C (lit.)
vapor density, 6.1 (vs air)
vapor pressure, <1 mm Hg ( 20 °C)
refractive index, n20/D 1.440(lit.)
Flash point, >230 °F
storage temp., Inert atmosphere,Room Temperature
solubility, alcohol: soluble(lit.)
form, Liquid
color, Clear colorless
PH, 5-6 (50g/l, H2O, 20℃)
Odor, at 100.00 %. very mild alcoholic
Odor Type, alcoholic
Water Solubility, Soluble in water, alcohol, ether, benzene
Sensitive, Hygroscopic
Merck, 14,2961
BRN, 1706903
LogP, -0.640
Indirect Additives used in Food Contact Substances, GLYCEROL DIACTATE
FDA 21 CFR, 177.1200
CAS DataBase Reference, 25395-31-7(CAS DataBase Reference)
EWG's Food Scores, 1
FDA UNII, GJ0544W99Q
NIST Chemistry Reference, 1,2,3-Propanetriol, diacetate(25395-31-7)
EPA Substance Registry System, 1,2,3-Propanetriol, diacetate (25395-31-7)



SAFETY INFORMATION ABOUT GLYCERYL DIACETATE (DIACETIN):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



GLYCERYL ISOSTEARATE
GLYCERYL LACTATE, N° CAS : 26855-41-4. Nom INCI : GLYCERYL LACTATE. Nom chimique : Propanoic acid, 2-hydroxy-, monoester with 1,2,3-propanetrio1