Other Industries

PIGMENT YELLOW 110
Pigment Yellow 110 is an organic dye used as a compostable colorant for bio-plastics.
Pigment Yellow 110 is an opaque reddish isoindoline pigment yellow 110 with excellent light and weather fastness, average hiding power, good resistance to bleeding and resistant to most organic solvents.


CAS Number: 5590-18-1
EC Number: 226-999-5
Molecular Formula: C22H6Cl8N4O2


Pigment Yellow 110 has a thermal stability (DIN 12877) of 300 °C.
Pigment Yellow 110 is an industry standard red shade yellow pigment with excellent heat and weather resistance.
Pigment Yellow 110 is an FDA organic pigment yellow and one of the most lightfast and weather fast organic yellow pigments known.
Pigment Yellow 110's overall fastness properties are considered as the best among all reddish yellow pigments.


Pigment Yellow 110 shows average tint strength.
Between 1.4% and 1.9% Pigment Yellow 110 is needed to formulate 1/3 SD colorations with 5% TiO2, depending on the type.
Pigment Yellow 110 has serious shrinkage effect when using in HDPE.
Pigment Yellow 110 is very sensitive to due to its crystal needle shape.


Pigment Yellow 110 acts as an organic pigment.
Pigment Yellow 110 is a semi-transparent, reddish shade Isoindolinone Yellow (PY110) pigment offering excellent light fastness and good overall fastness properties with good dispersibility.


Pigment Yellow 110 has bright color, possesses strong coloring power, excellent processing stability, good dispersibility, high transparency, high heat resistance, good light permanency and acid fastness to alkali and has no migration property.
Pigment Yellow 110 is a reddish yellow pigment, with excellent processing stability, good dispersibility, high transparency, excellent heat and outstanding fastness properties.


Pigment Yellow 110 affords very reddish shades of yellow.
Good fastness properties make Pigment Yellow 110 a widely used pigment.
Pigment Yellow 110 also shows excellent durability in rigid PVC and impact resistant PVC types, as well as in plastisols for coil coating.
Pigment Yellow 110 is fast to bleeding.


Pigment Yellow 110 is also very lightfast in polyolefins.
Pigment Yellow 110 can be analyzed by this reverse phase (RP) HPLC method with simple conditions.
The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid.
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid.


Smaller 3 µm particles columns available for fast UPLC applications.
Pigment Yellow 110 is greenish shade yellow pigment and reddish shade light yellow pigment.
Pigment Yellow 110 has excellent heat, light resistance, migration resistance, and solvent resistance.
Pigment Yellow 110 is one of top organic pigment yellow with excellent light resistance and weather resistance.


Pigment Yellow 110 is very sensitive to due to its crystal needle shape.
Pigment Yellow 110 is a strong red light yellow, can match the US FDA standards, light resistance is the best among red yellow pigments.
Furthermore, Pigment Yellow 110 has excellent performance in heat resistance and migration resistance.


Pigment yellow 110 primary particles are needle-shaped crystals, used in crystal plastics such as HDPE, will affect the deformation of warpage.
Pigment Yellow 110 is a reddish-yellow pigment, with excellent processing stability, good dispersibility, high transparency, excellent heat and outstanding fastness properties.



USES and APPLICATIONS of PIGMENT YELLOW 110:
Pigment Yellow 110 is used in automotive finishes, emulsion paints, architectural paints, water-based dispersions and in many plastic applications.
Pigment Yellow 110 is suitable for all indoor and outdoor usage.


Pigment Yellow 110 can be used for all coatings but is recommended for the highest-end coatings applications where very good to excellent weather-fastness and heat stability are required.
Pigment Yellow 110 is recommended for automotive paints, architectural paints, industrial paints, powder coatings, printing pastes, PVC, rubber, PS, PP, PE, PU, water based inks, solvent inks, UV inks.


Pigment Yellow 110 can be used for coil coating, offset ink.
Pigment Yellow 110 gave a strong red light yellow.
Among them, the specific surface area of Irgazin Yellow 2RLT is 56m2 / g, and its light fastness, weather fastness, heat resistance and migration resistance are excellent, which makes Pigment Yellow 110 widely used.


Pigment Yellow 110 is mainly used in metal decorative paints, automotive coatings and latex paints.
Pigment Yellow 110 shows excellent thermal stability in plastic coloring (soft PVC can withstand 200 ℃ / 30min), light fastness (grade 7-8 under 1 / 25SD).
Pigment Yellow 110 is known as one of the most lightfast varieties of yellow organic pigments; heat resistance up to 290 ℃ in HDPE (1 / 3SD).


Pigment Yellow 110 is suitable for the coloring of virgin pulp of polypropylene, polyacrylonitrile and polyamide.
Pigment Yellow 110 is also used in various printing inks, good Solvent resistance, heat resistance and sterilization resistance; art pigments, solvent-based wood coloring, etc.
Pigment Yellow 110 is a reddish shade Isoindolinone Yellow pigment suitable for paints, coatings and plastics applications.


Pigment Yellow 110 is a recommended pigment for paints, coatings and plastics applications.
Pigment Yellow 110 is mainly used in paint, offset inks and UV inks.
Pigment Yellow 110 can also be used in water based ink and textile printing.
Pigment Yellow 110's high heat stability is used to advantage in polyolefins.


Pigment Yellow 110 has considerable effect on the shrinkage of this partially crystalline polymer at processing temperatures between 220 and 280°C.
The paint industry uses the relatively weak Pigment Yellow 110 frequently as a colorant for industrial finishes, especially for high grade finishes.


Pigment Yellow 110 is very lightfast and weatherfast, which also makes it a suitable product for automotive finishes, for instance original automotive finishes.
Recommended uses of Pigment Yellow 110 for all paints, plastic, Fibre and offset inks, UV inks.
Pigment Yellow 110 is suggested for water based ink and textile printing.


Pigment Yellow 110 also suitable for pharmacokinetics.
Pigment Yellow 110 is the most weather resistant, red shade organic yellow pigment available for the coloration of PVC, Polyolefin and Styrenic exterior applications.
Pigment Yellow 110 maintains its outstanding performance in highly reduced shades with Titanium Dioxide or other inorganic pigments.


Pigment Yellow 110 is mainly applied in industrial paints,coil coatings, powder coatings, automotive refinish paints, high-temperature baking paints, exterior wall coatings.
Pigment Yellow 110 can printing inks,offset printing inks, leather printing pastes, and PE, PP, PVC, PS, PU, engineering plastics and other products.


In coloring plastics, Pigment Yellow 110 has no migration, temperature resistance of 300 degrees, and high color strength.
There are 23 types of this product, giving a strong red and yellow color.
Pigment Yellow 110 has a specific surface area of 56 m2/g, and is excellent in light resistance, weather fastness, heat resistance and migration resistance, which makes it widely used.


Pigment Yellow 110 is mainly used in metal decorative paint, automotive coatings and latex paint; Plastic coloring shows excellent thermal stability (soft PVC can withstand 200 C/30min), light fastness (1/25SD 7-8), is one of the most light-resistant varieties of known yellow organic pigments; In HDPE (1/3SD) heat resistance up to 290 deg C.
Pigment Yellow 110 is suitable for polypropylene, polyacrylonitrile and polyamide pulp coloring.


Pigment Yellow 110 is also used for a variety of printing ink, good solvent resistance, heat resistance and sterilization treatment; Art pigments, solvent-based wood coloring.
Pigment Yellow 110 is reddish yellow pigment, with excellent processing stability, good dispersing ability, high transparency, excellent heat and outstanding fastness properties. Pigment Yellow 110 is recommended for all paints, plastic, Fiber and offset inks, UV inks.


Pigment Yellow 110 is suggested for water based ink and textile printing.
Pigment Yellow 110 is used Water-base decorative paint, solvent-base decorative paint, industrial paint, powder coating, automotive paint, coil coating, textile paint.


Pigment Yellow 110 has bright color, strong coloring power, high heat resistance, good light permanency and high solvent resistance and migration resistance.
Pigment Yellow 110 is mainly used in printing ink, paints, first-class plastic resin, printing paste, soft plastic & rubber products and so on.
Pigment Yellow 110 is mainly used in coloring plastic, coating and paint.


Pigment Yellow 110 can also be used in coloring raw liquor of synthetic fiber.
Pigment yellow 110 is red shade yellow, has excellent heat and weather resistance suitable for all indoor and outdoor usage.
Pigment Yellow 110 is one of the most lightfast and weather fast organic yellow pigments known.
Pigment Yellow 110's overall fastness properties are considered as the best among all reddish yellow pigments.


Pigment yellow 110 has serious shrinkage effect when using in HDPE.
Pigment yellow 110 can be used in various kinds of plastic, such as PVC, PUR, polystyrene, polyolefins, polypropylene fibers.
Pigment Yellow 110 i also recommended for use in automotive finishes, emulsion paints, architectural paints, general industrials, baking enamels, various printing inks, and water based dispersions.


Pigment yellow 110 affords very reddish yellow transparent shade, exhibits very good fastness properties, include the light fastness, heat resistance and bleeding fastness.
Pigment yellow 110 can be widely used for coatings, printing inks and plastics.
Uses of Pigment Yellow 110: Intermediates, Paints and coatings


Pigment yellow 110 is recommended for use in a wide range of plastics including polypropylene fibers, polyolefins, polystyrene, PUR and PVC.
Pigment Yellow 110 is also recommended for use in automotive finishes, general industrials, baking enamels and various printing inks.
Pigment Yellow 110 is a semi-opaque, red shade yellow isoindolinone pigment with excellent lightfastness and heat stability


Pigment yellow 110 can be used in various kinds of plastic, such as PVC, PUR, polystyrene, polyolefins, polypropylene fibers.
Pigment Yellow 110 is also recommended for use in automotive finishes, emulsion paints, architectural paints, general industrials, baking enamels, various printing inks, and water-based dispersions.


-Applications of Pigment Yellow 110:
*Inks:
Pigment Yellow 110 is used well for all types printing;
*Coatings:
Pigment Yellow 110 is used for industrial finishes, especially high grade finishes, emulsion and architectural paints;
*Plastics:
Pigment Yellow 110 is used well for all types plastics.



PROPERTIES AND APPLICATIONS OF PIGMENT YELLOW 110:
*Pigment Yellow 110 is red light yellow.
*Pigment Yellow 110 have good light fastness, weather fastness, suitable for PVC, PO color, in nonpolar plastics have high thermal stability and excellent outdoor weatherability.



FEATURES OF PIGMENT YELLOW 110:
Pigment Yellow 110 is yellow powder with strong red shade.
Pigment Yellow 110 has very excellent heat resistance in PVC coloring and is stable around 200℃ for 30 minutes.
And in HDPE(1/3SD), the heat resistance can reach 290 ℃. Pigment Yellow 110 also has high weather and migration resistance.
With the excellent properties, Pigment Yellow 110 can be used in metal decorative paint, automotive paint and latex paint.
The light fastness of Pigment Yellow 110 is 7-8 and is one of the best among all the current azo pigments.
Under the condition of 1/25SD, the light fastness can be 7-8.



PHYSICAL and CHEMICAL PROPERTIES of PIGMENT YELLOW 110:
Boiling point : 808.6±75.0 °C(Predicted)
density: 1.93
vapor pressure : 0Pa at 25℃
pka: -3.55±0.20(Predicted)
Water Solubility: 10μg/L
LogP: 5.2 at 25℃
PH Value: 7.7
Density (g/cm3 ): 1.3
Oil Absorption (ml/100g): 60
Light: 4
Heat (°C): 150
Water: 5
Linseed Oil: 4
Acid: 3
Alkali: 5

Molecular Formula: C22H6Cl8N4O2
Molar Mass: 641.93
Density: 1.93
Boling Point: 808.6±75.0 °C(Predicted)
Flash Point: 442.8°C
Water Solubility: 10μg/L
Vapor Presure: 0Pa at 25℃
pKa: -3.55±0.20(Predicted)
Storage Condition: Room Temprature
Refractive Index: 1.801
hue or color: red and yellow
density/(g/cm3):1.82
Bulk density/(lb/gal):15.1
melting point/℃:300
specific surface area/(m2/g):26(3RLTN)
pH value/(10% slurry):6.5-8.7
oil absorption/(g/100g):36-77
hiding power: transparent
Appearance : Colorless to light yellow transparent liquid

Assay : ≥99.0%
Density: 1.467g/cm3
Melting point: N/A
Boiling Point: 177.9℃ at 760 mmHg
Flash Point: 71.1℃
Refractive Index: 1.423
Vapor Pressure: 1.0mmHg at 25℃
PSA: 26.02000
LogP:3.88760
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly).
Physical Form : Yellow Powder
Heat Resistance(º C): 220
Density (g/cm3): 1.8
Specific Surface(m2/g): 27
PH Value: 6.0-70
Oil Absorption(ml/100g): 50

Molecular Weight: 641.93300g/mol
Molecular Formula: C22H6Cl8N4O2
Compound Is Canonicalized: True
XLogP3-AA: 8.2
Exact Mass: 641.793997
Monoisotopic Mass: 637.799897
Complexity: 900
Rotatable Bond Count: 2
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Topological Polar Surface Area: 82.9
Heavy Atom Count: 36
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1



FIRST AID MEASURES of PIGMENT YELLOW 110:
-Description of necessary first-aid measures:
*If inhaled:
Move the victim into fresh air.
*Following skin contact:
Take off contaminated clothing immediately.
Wash off with soap and plenty of water.
Consult a doctor.
*Following eye contact:
Rinse with pure water for at least 15 minutes.
Consult a doctor.
*Following ingestion:
Rinse mouth with water.
Do not induce vomiting.
-Most important symptoms/effects, acute and delayed:
no data available
-Indication of immediate medical attention and special treatment needed, if necessary:
no data available



ACCIDENTAL RELEASE MEASURES of PIGMENT YELLOW 110:
-Environmental precautions:
Prevent further spillage or leakage if it is safe to do so.
Do not let the chemical enter drains.
Discharge into the environment must be avoided.
-Methods and materials for containment and cleaning up:
Collect and arrange disposal.
Keep the chemical in suitable and closed containers for disposal.



FIRE FIGHTING MEASURES of PIGMENT YELLOW 110:
-Suitable extinguishing media:
Use dry chemical, carbon dioxide or alcohol-resistant foam.
-Specific hazards arising from the chemical:
no data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of PIGMENT YELLOW 110:
-Control parameters:
*Occupational Exposure limit values:
no data available
*Biological limit values:
no data available
-Appropriate engineering controls
Ensure adequate ventilation.
Handle in accordance with good industrial hygiene and safety practice.
-Individual protection measures, such as personal protective equipment (PPE):
*Eye/face protection:
Wear tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Thermal hazards:
no data available



HANDLING and STORAGE of PIGMENT YELLOW 110:
-Precautions for safe handling:
Handling in a well ventilated place.
-Conditions for safe storage, including any incompatibilities:
Store the container tightly closed in a dry, cool and well-ventilated place.
Store apart from foodstuff containers or incompatible materials.



STABILITY and REACTIVITY of PIGMENT YELLOW 110:
-Reactivity:
no data available
-Chemical stability:
no data available
-Possibility of hazardous reactions:
no data available
-Conditions to avoid:
no data available
-Incompatible materials:
no data available
-Hazardous decomposition products:
no data available



SYNONYMS:
Bis(4,5,6,7-Tetrachloro-3-oxoisoindolin-1-ylidene)-1,4-phenylenediamine
c.i. 56280;C.I. Pigment Yellow 137
pigment yellow 110
3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1h-isoindol-1-one
Yellow RLT
1H-Isoindol-1-one, 3,3-(1,4-phenylenediimino)bis4,5,6,7-tetrachloro-
1,4-Phenylenediaminebis(4,5,6,7-tetrachloroisoindolin-1-one-3-ylidene)
1,4-Phenylenediaminebis(4,5,6,7-tetrachloroisoindolin-1-one-3-ylidene)
1H-Isoindol-1-one, 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-
1H-Isoindol-1-one, 3,3'-(1,4-phenylenedinitrilo)bis(4,5,6,7-tetrachloro-2,3-dihydro-
3,3'-(1,4-Phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
Isoindolinone yellow
Irgazin Yellow K 2080
3,3'-(1,4-PHENYLENEDIIMINO)BIS(4,5,6,7-TETRACHLORO-1H-ISOINDOL-1-ONE
BIS(4,5,6,7-TETRACHLORO-3-OXOISOINDOLIN-1-YLIDENE )-1,4-PHENYLENEDIAMINE
CI 56280
CI PIGMENT YELLOW 110
CI PIGMENT YELLOW 137
CI 56280
ISOINDOLINONE YELLOW 3R
MBR 443
PIGMENT YELLOW 110
TETRACHLOROISOINDOLINONE YELLOW 2RLTS
YELLOW 2RLP
YELLOW 2RLT
YELLOW 3RLT
YELLOW E 2RL
YELLOW E 3RL
YELLOW RLT
YELLOW RX
56280
Yellow RLT
c.i. 56280
Pigment Yellow 110
pigment yellow 110
C.I. Pigment Yellow 110
C.I. Pigment Yellow 137
3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1h-isoindol-1-one
1H-Isoindol-1-one, 3,3-(1,4-phenylenediimino)bis4,5,6,7-tetrachloro-
1,4-Phenylenediaminebis(4,5,6,7-tetrachloroisoindolin-1-one-3-ylidene)
Bis(4,5,6,7-Tetrachloro-3-oxoisoindolin-1-ylidene)-1,4-phenylenediamine
3,3'-(benzene-1,4-diyldiimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
1H-Isoindol-1-one, 3,3'-(1,4-phenylenedinitrilo)bis(4,5,6,7-tetrachloro-2,3-dihydro-
3,3′-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1h-isoindol-1-one
Bis(4,5,6,7-Tetrachloro-3-oxoisoindolin-1-ylidene)-1,4-phenylenediamine
c.i. 56280
C.I. Pigment Yellow 137
pigment yellow 110
Yellow RLT
1H-Isoindol-1-one, 3,3-(1,4-phenylenediimino)bis4,5,6,7-tetrachloro-
1,4-Phenylenediaminebis(4,5,6,7-tetrachloroisoindolin-1-one-3-ylidene)
1H-Isoindol-1-one,3,3′-(1,4-phenylenedinitrilo)bis[4,5,6,7-tetrachloro-2,3-dihydro-
Phthalimidine,3,3′-(p-phenylenedinitrilo)bis[4,5,6,7-tetrachloro-
1H-Isoindol-1-one,3,3′-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-
3,3′-(1,4-Phenylenedinitrilo)bis[4,5,6,7-tetrachloro-2,3-dihydro-1H-isoindol-1-one]
Bis(4,5,6,7-Tetrachloro-3-oxoisoindolin-1-ylidene)-1,4-phenylenediamine
Irgazin Yellow 3RLTN
C.I. Pigment Yellow 110
Irgazin Yellow 2RLT
Irgazin Yellow 3RLT
C.I. Pigment Yellow 137
Fastogen Super Yellow GRO
Lionogen Yellow RX
Kayaset Yellow E 2RL
Fastogen Super Yellow GROH
Kayaset Yellow E 3RL
Isoindolinone yellow
Microlith Yellow 3RFP
Unisperse Yellow 2RLT-E
Pigment Yellow 110
C.I. 56280
Cromophtal Yellow 2RLTS
Isoindolinone Yellow 3R
Microlen Yellow 2RLTS-UA
Microlith Yellow 3R-K
Cromophtal Yellow 2RLP
Microlith Yellow 3R-T
Yellow 2RLP
Dymic MBR 443
MBR 443
Irgazin 3RLTN
Irgazin Yellow 3RLTE
Cromophtal Yellow 3RT
Irgazin Yellow L 2040
PY 110
Discoall Color DAP 4446
DAP 4446
Cinilex Yellow SY 2T
Irgazin Yellow K 2060
Irgazin Yellow K 2080
Irgazin Yellow K 2060SQ
Irgazin Yellow L 2060
Dymic MBR 443 Yellow
Irgazin Yellow K 2060FP
12679-90-2
74913-55-6
80619-34-7
93907-21-2
362044-36-8
618914-02-6



PIGMENT YELLOW 111

Pigment Yellow 111 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 111 is a benzimidazolone-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 111 is C18H16N4O4, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 8003-22-3
EC Number: 232-303-8

Synonyms: Benzimidazolone Yellow 111, Permanent Yellow H10G, CI Pigment Yellow 111, Fast Yellow H10G, Irgazin Yellow 5GLT, Hostaperm Yellow H10G, Permanent Yellow H10GL, Benzimidazolone Yellow H10GL, Pigment Yellow H10G, Irgazin Yellow H10G, Hostaperm Yellow H10GL, Fast Yellow 111, Permanent Yellow H10G, CI 56280, Benzimidazolone Yellow H10GL, Pigment Yellow 5GLT, Benzimidazolone Yellow H10GLT, Fast Yellow H10G, Permanent Yellow 5GL, Irgazin Yellow H10GL, Hostaperm Yellow 5GL, Benzimidazolone Yellow H10GLT, Permanent Yellow H10G, CI Pigment Yellow 5GL, Fast Yellow H10GL, Hostaperm Yellow 111, Irgazin Yellow 111, Benzimidazolone Yellow H10G, Pigment Yellow H10G, CI Pigment Yellow H10G, Permanent Yellow H10GL, Benzimidazolone Yellow 5GL, Irgazin Yellow H10G, Hostaperm Yellow H10GL



APPLICATIONS


Pigment Yellow 111 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 111 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 111 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 111 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 111 is used in automotive coatings for its excellent durability.
Pigment Yellow 111 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 111 is used in water-based paints for its stability and brightness.
Pigment Yellow 111 is a key component in solvent-based paints and coatings.
Pigment Yellow 111 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 111 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 111 is used in the manufacturing of synthetic fibers.
Pigment Yellow 111 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 111 is used in the creation of artist paints and materials.
Pigment Yellow 111 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 111 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 111 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 111 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 111 is essential in the creation of high-quality printing inks.

Pigment Yellow 111 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 111 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 111 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 111 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 111 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 111 is a key ingredient in the production of plastic colorants.

Pigment Yellow 111 is employed in the textile industry to dye fabrics.
Pigment Yellow 111 is used in the rubber industry for coloring rubber products.
Pigment Yellow 111 is essential in the production of artist materials.

Pigment Yellow 111 is a vital component in water-based and solvent-based systems.
Pigment Yellow 111 is applied in the creation of high-performance industrial products.
Pigment Yellow 111 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 111 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 111 is found in the creation of specialty inks for various applications.
Pigment Yellow 111 is used in the production of ceramic and glass products.

Pigment Yellow 111 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 111 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 111 is essential in the production of coatings for wood surfaces.

Pigment Yellow 111 is used in the formulation of high-performance inks.
Pigment Yellow 111 is applied in the creation of coatings for automotive applications.
Pigment Yellow 111 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 111 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 111 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 111 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 111 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 111 is used in the creation of specialty inks for digital printing.
Pigment Yellow 111 is essential in the production of high-performance industrial products.

Pigment Yellow 111 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 111 is used in the creation of water-based and solvent-based products.
Pigment Yellow 111 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 111 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 111 is a benzimidazolone-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 111 is a versatile organic compound with the chemical formula C18H16N4O4.
Pigment Yellow 111 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 111 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 111 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 111 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 111 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 111's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 111 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 111 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 111's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 111 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 111 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C18H16N4O4
Common Name: Pigment Yellow 111
Molecular Structure: C18H16N4O4
Molecular Weight: 352.35 g/mol
Appearance: Bright yellow powder
Density: 1.4 g/cm³
Melting Point: 250-270°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:

If Pigment Yellow 111 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 111.
Wash hands thoroughly after handling.

PIGMENT YELLOW 13

Pigment Yellow 13 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 13 is a benzimidazolone-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 13 is C18H18N4O6, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 5102-83-0
EC Number: 225-822-9

Synonyms: Benzimidazolone Yellow, Permanent Yellow 3G, CI Pigment Yellow 13, Fast Yellow 3G, Permanent Yellow GR, Fast Yellow GR, Benzimidazolone Yellow 3G, Pigment Yellow 3G, Irgazin Yellow 3GLT, Hostaperm Yellow GR, Benzimidazolone Yellow GR, PY13, Benzimidazolone Pigment Yellow, Yellow 3G, Permanent Benzimidazolone Yellow, CI 21100, CI 21105, Pigment Yellow 3GLT, Permanent Yellow GR 3G, Fast Benzimidazolone Yellow, Benzimidazolone Yellow GR, Hostaperm Yellow 3G, Permanent Yellow G, Hansa Yellow 3G, Irgazin Yellow GR, Permanent Yellow 3GLT, Irgazin Yellow 3G, CI Pigment Yellow 3G, Hostaperm Yellow GR 3G, Fast Yellow GR 3G, Hansa Yellow GR 3G, Benzimidazolone Yellow 3GR, Permanent Yellow GR 3GLT, Benzimidazolone Yellow G, Benzimidazolone Yellow GR 3G, Permanent Yellow GR 3G, CI Pigment Yellow GR 3G, Permanent Yellow GRLT, Hostaperm Yellow GRLT, Benzimidazolone Yellow 3GLT, Fast Yellow GRLT, Hostaperm Yellow 3GLT



APPLICATIONS


Pigment Yellow 13 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 13 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 13 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 13 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 13 is used in automotive coatings for its excellent durability.
Pigment Yellow 13 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 13 is used in water-based paints for its stability and brightness.
Pigment Yellow 13 is a key component in solvent-based paints and coatings.
Pigment Yellow 13 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 13 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 13 is used in the manufacturing of synthetic fibers.
Pigment Yellow 13 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 13 is used in the creation of artist paints and materials.
Pigment Yellow 13 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 13 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 13 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 13 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 13 is essential in the creation of high-quality printing inks.

Pigment Yellow 13 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 13 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 13 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 13 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 13 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 13 is a key ingredient in the production of plastic colorants.

Pigment Yellow 13 is employed in the textile industry to dye fabrics.
Pigment Yellow 13 is used in the rubber industry for coloring rubber products.
Pigment Yellow 13 is essential in the production of artist materials.

Pigment Yellow 13 is a vital component in water-based and solvent-based systems.
Pigment Yellow 13 is applied in the creation of high-performance industrial products.
Pigment Yellow 13 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 13 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 13 is found in the creation of specialty inks for various applications.
Pigment Yellow 13 is used in the production of ceramic and glass products.

Pigment Yellow 13 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 13 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 13 is essential in the production of coatings for wood surfaces.

Pigment Yellow 13 is used in the formulation of high-performance inks.
Pigment Yellow 13 is applied in the creation of coatings for automotive applications.
Pigment Yellow 13 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 13 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 13 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 13 is used in the formulation of high-performance coatings for various applications.



DESCRIPTION


Pigment Yellow 13 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 13 is a benzimidazolone-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 13 is a versatile organic compound with the chemical formula C18H18N4O6.
Pigment Yellow 13 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 13 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 13 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 13 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 13 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 13's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 13 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 13 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 13's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 13 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 13 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C18H18N4O6
Common Name: Pigment Yellow 13
Molecular Structure: C18H18N4O6
Molecular Weight: 386.37 g/mol
Appearance: Bright yellow powder
Density: 1.5 g/cm³
Melting Point: >300°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 13 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 13.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 13 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 13 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 13 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 13 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
PIGMENT YELLOW 138

Pigment Yellow 138 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 138 is a benzimidazolone-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 138 is C22H6Cl4N4O2, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 30125-47-4
EC Number: 250-063-5

Synonyms: Benzimidazolone Yellow H3G, Permanent Yellow H3G, CI Pigment Yellow 138, Fast Yellow H3G, Irgazin Yellow 3GLT, Hostaperm Yellow H3G, Permanent Yellow H3GL, Benzimidazolone Yellow 138, Pigment Yellow H3G, Irgazin Yellow H3G, Hostaperm Yellow H3GL, Fast Yellow 138, Permanent Yellow H3G, CI 56280, Benzimidazolone Yellow H3GL, Pigment Yellow 3GLT, Benzimidazolone Yellow H3GLT, Fast Yellow H3G, Permanent Yellow 3GL, Irgazin Yellow H3GL, Hostaperm Yellow 3GL, Benzimidazolone Yellow H3GLT, Permanent Yellow H3G, CI Pigment Yellow 3GL, Fast Yellow H3GL, Hostaperm Yellow 138, Irgazin Yellow 138, Benzimidazolone Yellow H3G, Pigment Yellow H3G, CI Pigment Yellow H3G, Permanent Yellow H3GL, Benzimidazolone Yellow 3GL, Irgazin Yellow H3G, Hostaperm Yellow H3GL



APPLICATIONS


Pigment Yellow 138 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 138 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 138 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 138 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 138 is used in automotive coatings for its excellent durability.
Pigment Yellow 138 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 138 is used in water-based paints for its stability and brightness.
Pigment Yellow 138 is a key component in solvent-based paints and coatings.
Pigment Yellow 138 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 138 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 138 is used in the manufacturing of synthetic fibers.
Pigment Yellow 138 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 138 is used in the creation of artist paints and materials.
Pigment Yellow 138 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 138 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 138 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 138 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 138 is essential in the creation of high-quality printing inks.

Pigment Yellow 138 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 138 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 138 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 138 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 138 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 138 is a key ingredient in the production of plastic colorants.

Pigment Yellow 138 is employed in the textile industry to dye fabrics.
Pigment Yellow 138 is used in the rubber industry for coloring rubber products.
Pigment Yellow 138 is essential in the production of artist materials.

Pigment Yellow 138 is a vital component in water-based and solvent-based systems.
Pigment Yellow 138 is applied in the creation of high-performance industrial products.
Pigment Yellow 138 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 138 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 138 is found in the creation of specialty inks for various applications.
Pigment Yellow 138 is used in the production of ceramic and glass products.

Pigment Yellow 138 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 138 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 138 is essential in the production of coatings for wood surfaces.

Pigment Yellow 138 is used in the formulation of high-performance inks.
Pigment Yellow 138 is applied in the creation of coatings for automotive applications.
Pigment Yellow 138 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 138 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 138 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 138 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 138 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 138 is used in the creation of specialty inks for digital printing.
Pigment Yellow 138 is essential in the production of high-performance industrial products.

Pigment Yellow 138 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 138 is used in the creation of water-based and solvent-based products.
Pigment Yellow 138 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 138 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 138 is a benzimidazolone-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 138 is a versatile organic compound with the chemical formula C22H6Cl4N4O2.
Pigment Yellow 138 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 138 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 138 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 138 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 138 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 138's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 138 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 138 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 138's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 138 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 138 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C22H6Cl4N4O2
Common Name: Pigment Yellow 138
Molecular Structure: C22H6Cl4N4O2
Molecular Weight: 505.11 g/mol
Appearance: Bright yellow powder
Density: 1.5 g/cm³
Melting Point: >300°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 138 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 138.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 138 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 138 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 138 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 138 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.


PIGMENT YELLOW 139
Pigment yellow 139 is an organic compound that is used as a yellow-orange pigment.
Pigment Yellow 139 is classified as a derivative of isoindoline.
Pigment Yellow 139 is virtually insoluble in most solvents.


CAS Number: 36888-99-0
EC Number: 253-256-2
Molecular Formula: C16H9N5O6


Pigment yellow 139 is an organic compound that is used as a yellow-orange pigment.
Pigment Yellow 139 is classified as a derivative of isoindoline.
This yellow-orange solid is virtually insoluble in most solvents.
Pigment Yellow 139 provides a transparent red-shade yellow with excellent lightfastness, excellent resistance to migration, and low-warping in HDPE injection molding.


Pigment Yellow 139 has excellent organic solvents/plasticizer and chemical resistance.
There is no interaction with Zn-Stearate/ Mg-Stearate during polyolefin plastics process.
Pigment Yellow 139 – TCY13904 is an Isoindoline Yellow pigment which is designed for the coloration of plastics.
Pigment Yellow 139 is a high opacity and reddish isoindoline pigment.


Pigment Yellow 139 is an opaque, reddish Isoindoline Yellow pigment with average color strength offering good light and weather fastness.
Pigment Yellow 139 is an Isoindoline organic pigment that is suitable for a wide range of paints and industrial coatings.
Pigment Yellow 139 is an opaque, reddish Isoindoline Yellow pigment with average color strength offering good light and weather fastness.
Pigment Yellow 139 is a transparent red shade yellow pigment, recommended for films and PP fibers application.


Pigment Yellow 139 is halogen-free and cost-effective, could mix together with Inorganic to replace chrome yellow, and replace pigment yellow 83 of benzidine structure.
Pigment Yellow 139 could color becomes duller at higher temperatures than 250℃, which is a result of pigment decomposition.
There are 20 kinds of commercial dosage forms of the pigment.


The non-transparent type presents stronger red light (Paliotol Yellow 1970 specific surface area is 22 m2/g, Pigment Yellow 139 specific surface area is 25 m2/g), increasing the concentration does not affect the gloss, and has excellent light resistance and climate fastness.
Combine with inorganic pigments instead of chrome yellow. Pigment Yellow 139 is suitable for high-grade coatings (auto repair paint), with light resistance of 7-8 grade (1/3SD) in alkyd triamine resin.


Although the thermal stability limit temperature of pigment yellow 139 is 260 ℃, the stability of Pigment Yellow 139 yellow in plastic processing is not high.
Pigment Yellow 139, English name is pigment yellow 139, Chinese alias is C.I pigment yellow 139.
Pigment Yellow 139 is suitable for red yellow of coatings, plastics and printing inks, is a high-performance organic yellow pigment, strong coloring power, good firmness.


Pigment Yellow 139 has different particle size distributions show different color characteristics, and the hue angle can be 78, 71 and 66 degrees according to the average particle size.
Pigment Yellow 139 is an organic compound that is used as a yellow-orange pigment.
Pigment Yellow 139 is classified as a derivative of isoindoline. Pigment Yellow 139 is virtually insoluble in most solvents.


The species is prepared by addition of ammonia to o-phthalonitrile to give the diiminoisoindoline, which in turn condenses with barbituric acid.
Pigment Yellow 139 is halogen-free and cost-effective, could mix together with Inorganic to replace chrome yellow, and replace pigment yellow 83 of benzidine structure.
Pigment Yellow 139 shows average tinctorial strength in plastics.


Approximately 1% pigment is required to produce 1/3 SD samples in plasticized PVC containing 5% TiO2.
Pigment Yellow 139 could color becomes duller at higher temperatures than 250℃, which is a result of pigment decomposition.
Pigment Yellow 139 is prepared by addition of ammonia to o-phthalonitrile to give the diiminoisoindoline, which in turn condenses with barbituric acid.


Pigment Yellow 139 is an opaque reddish isoindoline pigment yellow 139 with excellent fastness to light and weathering and very good flow properties.
Pigment Yellow 139 is a red shade yellow pigment with high color strength.
Pigment Yellow 139 is yellow colored, odorless, organic pigment.


Pigment Yellow 139 shows insolubility in water.
Pigment Yellow 139 is non-flammable and non-explosive.
Pigment Yellow 139 is a reddish yellow pigment powder, with excellent processing stability, high transparency, excellent heat resistance and light fastness.


Pigment yellow 139 is an organic compound that is used as a yellow-orange pigment.
Pigment Yellow 139 is classified as a derivative of isoindoline.
Pigment Yellow 139 is an opaque reddish yellow shade isoindoline pigment.
Pigment Yellow 139 provides a transparent red-shade yellow with excellent lightfastness, excellent resistance to migration, and low-warping in HDPE injection molding.


Pigment Yellow 139 has excellent organic solvents/plasticizer and chemical resistance.
There is no interaction with Zn-Stearate/Mg-Stearate during polyolefin plastics process.
Pigment Yellow 139 changes color depending on the pH of the environment, and it undergoes polymerization when irradiated with radiation or an acid complex.


Pigment Yellow 139 is also soluble in glycol esters and polycarboxylic acids.
Pigment Yellow 139 is produced by reacting hydroxyl groups with polycarboxylic acid products.
The pigments are then converted to particles by crystallizing them using a reaction product of particle emission.
Pigment Yellow 139 has a crystalline structure composed of irregularly shaped particles that are about 0.2-0.4 micrometers in diameter.



USES and APPLICATIONS of PIGMENT YELLOW 139:
Pigment Yellow 139 is recommended for PVC, PO, Fiber, PS, PC, PA.
Pigment Yellow 139 is used plastic.
Recommended Application of Pigment Yellow 139: Printing,water-base coating, solvent-base coating, water-base ink,solvent-base ink,offset ink.
Main application of Pigment Yellow 139: Plastic


Pigment Yellow 139 is suitable for paint, plastic and printing ink.
The different particle size distribution shows different color characteristics.
The hue angle can be 78, 71, 66 degrees depending on the average particle size; the non-transparent type presents stronger red light ( Paliotol Yellow 1970 has a specific surface area of 22m2/g and L2140HD has a specific surface area of 25m2/g).


Increasing the concentration does not affect gloss and has excellent light and weather fastness.
Pigment Yellow 139 can be used with inorganic pigments to replace chrome yellow.
Pigment Yellow 139 is suitable for high-end coatings (auto repair paint), with light resistance of 7-8 (1/3SD) in alkyd melamine resin; resistance to bleeding in soft PVC, and temperature resistance of 250 in HDPE (1/3SD) ℃, suitable for polypropylene.


Pigment Yellow 139 shows average tinctorial strength in plastics.
Approximately 1% Pigment Yellow 139 is required to produce 1/3 SD samples in plasticized PVC containing 5% TiO2.
Pigment Yellow 139 is a recommended pigment for many paints and coatings applications.
Pigment Yellow 139 is bleed resistant in plasticized PVC.


Pigment Yellow 139 can be used as color composition for dye multimer, film, color filter, solid-state imaging element, and image display device.
Pigment Yellow 139 is a Reddish shade pigment, with excellent kind properties and high luster, high Color Strength.
Pigment Yellow 139 is recommended for industrial paint, powder coating,
Pigment Yellow 139 is suggested for OEM paint, coil coating, water based ink and textile printing.


Pigment Yellow 139 is suitable for paint, plastic and ink red and yellow, different particle size distribution shows different color characteristics, hue angle according to the average particle size of 78, 71, 66 degrees; the non-transparent type exhibits stronger red light (the specific surface area of Paliotol Yellow 1970 is 22 m2/g, the specific surface area of L2140HD is 25 m2/g), and increasing the concentration does not affect the gloss, it has excellent light and weather fastness.


Pigment Yellow 139 is used in combination with inorganic pigment instead of chrome yellow.
Pigment Yellow 139 is suitable for high-grade coatings (automotive repair paint), in alkyd melamine resin light resistance up to 7-8 (1/3sd); In the soft PVC bleeding resistance, in HDPE (1/3sd) temperature resistance 250 ℃, suitable for polypropylene, unsaturated.
Pigment Yellow 139 is widely used in printing ink and plastic products coloring, especially some high-performance industrial products.


Pigment Yellow 139 can be mainly used for plastic products with low processing temperature, such as PVC and low density polyethylene.
Pigment Yellow 139 is used for resins with high processing temperature, such as PET,PMMA,PC,PA, etc.
Pigment Yellow 139 will change color and decompose during processing.
Isoindoline pigments exhibits excellent light fastness properties, offers good heat stability and chemical inertness and is suitable for many paints and coatings applications.


Pigment Yellow 139 is a recommended pigment for many paints and coatings applications.
PY139 is bleed resistant in plasticized PVC.
Pigment Yellow 139 is recommended for powder coating, PVC, rubber, PS, PP, PE, PU.
Pigment Yellow 139 can be used in coil coatings.


Pigment Yellow 139 may also be used as a substitute of medium chrome yellow.
Pigment Yellow 139 is suitable for the coloration of PVC, polyolefin, and PUR as well as engineering plastics PS, ABS, SAN, PET, PC, PMMA, etc.
Pigment Yellow 139 is used a biological dye and indicator.
Pigment Yellow 139 is used for lead-free paints with intense opaque yellow shades and for high grade industrial finishes, including automotive finishes.


Pigment Yellow 139 can be used as a replacement for diarylide and lead chromate pigments.
Pigment Yellow 139 is highly recommended for PP fiber applications.
Pigment Yellow 139 is used for applications like PO, PVC, rubber, PAN.
Pigment Yellow 139, a reddish shade of yellow, is suitable for paints, plastics and printing inks.


The particle size distribution of different cells show different color characteristics.
For example, the opaque type has a more reddish shade, with good gloss, light fastness and weather fastness.
Pigment Yellow 139 is mixed with inorganic pigments to replace Chrome yellow.
Pigment Yellow 139 is available in three different particle sizes for use in various applications.


Pigment Yellow 139 is a reddish yellow pigment, used in plastics, paints, and printing inks.
The commercial types of Pigment Yellow 139 exhibit a wide variety of particle size distributions and accordingly demonstrate very different coloristic properties, which is especially true for the hiding power.
The opaque version of Pigment Yellow 139 is considerably redder.


Incorporated in a paint, Pigment Yellow 139 is less viscous, which makes it possible to to increase the pigment concentration without affecting the gloss of the product.
Pigment Yellow 139 is a reddish shade pigment yellow powder.
Pigment Yellow 139 has both opaque and semi-opaque type.


The opaque type of Pigment Yellow 139 is more reddish than semi-opaque type.
The increase of using amount will not affect Pigment Yellow 139's gloss.
Pigment yellow 139 can be used together with inorganic pigment to replace chrome yellow.
Pigment Yellow 139 is suitable in the high end coating like car finish paint, and it has a light fastness of 7-8 in alkyed melamine resin.


Pigment Yellow 139 has a heat resistance of 250℃ in HDPE, but has color penetration problem in soft PVC.
Pigment Yellow 139 is more suitable for low temperature plastics.
Pigment Yellow 139 is used for coloration of most Plastics.
Pigment Yellow 139 is recommended for industrial paints, powder coatings.


Pigment Yellow 139 is suggested for coil coatings and automotive paints.
High opacity makes Pigment Yellow 139 suitable for solid shades in industrial and automotive coatings.
Pigment Yellow 139 is reddish yellow pigment having high opacity with excellent bleed resistance, lightfastness and weathering properties meant for coating application.


Pigment Yellow 139 is suitable for the coloration of PVC, polyolefin, and PUR as well as engineering plastics PS, ABS, SAN, PET, PC, PMMA, etc.
Pigment Yellow 139 is a colorant that is soluble in organic solvents and has a maximum absorption wavelength of 595 nm.
Pigment Yellow 139 can be used as an optical system polarizer, and it is also used in liquid crystal compositions.
Pigment Yellow 139 provides a transparent red-shade yellow with excellent lightfastness, excellent resistance to migration, and low-warping in HDPE injection molding.


Pigment Yellow 139 has excellent organic solvents/plasticizer and chemical resistance.
There is no interaction with Zn-Stearate/Mg-Stearate during polyolefin plastics process.
Pigment Yellow 139 is suitable for the coloration of PVC, polyolefin, and PUR as well as engineering plastics PS, ABS, SAN, PET, PC, paints and coatings.


Pigment Yellow 139 has a specific surface area of ​​56m/g, excellent light resistance, climate resistance, heat resistance and flow resistance, which makes it widely used.
Pigment Yellow 139 is organic pigment yellow for plastic has a specific surface area of ​​56m/g, excellent light resistance, climate resistance, heat resistance and flow resistance, which makes it widely used.


Pigment Yellow 139 is mainly used in metal decorative paint, automotive paint and latex paint.
Pigment Yellow 139 is widely used in building materials, coatings, plastics, electronics, tobacco, rubber, ceramics, ink, magnetic materials, papermaking and other fields.
Pigment Yellow 139 is suitable for coloring of PVC, polyolefin and PUR, as well as engineering resins PS, ABS, SAN, PET, PC, paints and coatings.


-Applications of Pigment Yellow 139:
*Coatings
*Decorative Paints
*Solvent Based
*Industrial Coatings
*General Industrial Paint
*Powder Coatings
*Automotive Coatings
*OEM
*Refinish



BENEFITS OF PIGMENT YELLOW 139:
*Excellent dispersability
*High color strength
*Diarylide replacement



PROPERTIES AND APPLICATIONS OF PIGMENT YELLOW 139:
*Pigment Yellow 139 is used red light yellow.
*Pigment Yellow 139 is used in high-grade coatings (car original primer), melting point > 400 ℃



KEY FEATURES OF PIGMENT YELLOW 139:
*Opaque reddish yellow shade
*Ideal for lead chrome replacement



FEATURES OF PIGMENT YELLOW 139:
*transparent.
Pigment Yellow 139 is a transparent red shade yellow pigment, recommended for films and PP fibers application.
There are two-grade Pigment Yellow 139, which 2R is Comparable With BASF K1841, which 3R is Comparable With BASF 2140.



PRODUCTION METHOD OF PIGMENT YELLOW 139:
Pigment Yellow 139 is obtained by condensation of diiminoisindoline and barbituric acid.
the phthalonitrile is added into the methanol solution of sodium cyanamide at 30~35 ℃, and stirred overnight at room temperature to obtain the product diimino isoindoline.
Diiminoisoindoline and barbituric acid are condensed in an aqueous medium containing formic acid at 60°C to obtain a yellow pigment.



PHYSICAL and CHEMICAL PROPERTIES of PIGMENT YELLOW 139:
Molecular Weight: 367.27
Density: 1.696g/cm3
Color: Yellow powder
Light Fastness: 6
Heat Resistance(℃): 200
Water Resistance: 4
Oil Resistance: 5
Acid Resistance: 5
Alkali Resistance: 5
Alcohol Resistance: 4
Molecular Weight: 367.27
XLogP3-AA: -0.9
Hydrogen Bond Donor Count: 5
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 1
Exact Mass: 367.055283
Monoisotopic Mass: 367.055283
Topological Polar Surface Area: 166 Ų
Heavy Atom Count: 27

Formal Charge: 0
Complexity: 892
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula: C16H9N5O6
Molar Mass: 367.27
Density: 1.696±0.06 g/cm3(Predicted)
pKa: 5.56±0.20(Predicted)
Refractive Index: 1.698
hue or shade: red and yellow
density/(g/cm3):1.74
Bulk density/(lb/gal):3.3;5.0
average particle size/μm:154-339
specific surface area/(m2/g):22;22;55
oil absorption/(g/100g):45-69
hiding power: translucent

Appearance: Yellow Powder
Shade: Similar to Standard
Tinting Strength:100%
Bulk Density(lb/gal): (Density(lb/gal):1.74)
Moisture: ≤1.5
Oil Absorption(ml/100g): 45-69 Fineness(120 Mesh): ≤5.0
PH Value: 8
Water Soluble Matter (%) ≤1.5 Electric Conductivity (us/cm) ≤500 Acid Resistance 5
Alkali Resistance 5
Water Resistance: 5
Oil Resistance: 5
Alcohol Resistance 5
Physical state: Reddish yellow powder
Colour: no data available
Odour: no data available
Melting point/ freezing point: no data available
Boiling point or initial boiling point and boiling range: no data available

Flammability: no data available
Lower and upper explosion limit / flammability limit: no data available
Flash point: no data available
Auto-ignition temperature: no data available
Decomposition temperature: no data available
pH: no data available
Kinematic viscosity: no data available
Solubility: no data available
Partition coefficient n-octanol/water (log value): no data available
Vapour pressure: no data available
Density and/or relative density: 1.696 g/cm3
Relative vapour density: no data available
Particle characteristics: no data available



FIRST AID MEASURES of PIGMENT YELLOW 139:
-Description of necessary first-aid measures:
*General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.
-Most important symptoms/effects, acute and delayed:
no data available
-Indication of immediate medical attention and special treatment needed, if necessary:
no data available



ACCIDENTAL RELEASE MEASURES of PIGMENT YELLOW 139:
-Environmental precautions:
Do not let product enter drains.
Discharge into the environment must be avoided.
-Methods and materials for containment and cleaning up:
Pick up and arrange disposal.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of PIGMENT YELLOW 139:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Specific hazards arising from the chemical:
no data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of PIGMENT YELLOW 139:
-Control parameters:
*Occupational Exposure limit values:
no data available
*Biological limit values:
no data available
-Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Individual protection measures, such as personal protective equipment (PPE):
*Eye/face protection:
Safety glasses with side-shields.
Use equipment for eye protection.
*Skin protection:
Wear impervious clothing.
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
-Thermal hazards:
no data available



HANDLING and STORAGE of PIGMENT YELLOW 139:
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of PIGMENT YELLOW 139:
-Reactivity:
no data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
no data available
-Conditions to avoid:
no data available
-Incompatible materials:
no data available
-Hazardous decomposition products:
no data available



SYNONYMS:
PIGMENT YELLOW 139
36888-99-0
5,5'-(1H-Isoindole-1,3(2H)-diylidene)dibarbituric acid
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5'-(1H-isoindole-1,3(2H)-diylidene)bis-
5-[3-(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)isoindol-1-ylidene]-1,3-diazinane-2,4,6-trione
C.I. Pigment Yellow 139
EINECS 253-256-2
1,3-Di(2,4,6-trioxohexahydro-5-pyrimidinylidene)isoindole
EC 253-256-2
UNII-ZW25289FVV
SCHEMBL2734090
ZW25289FVV
DTXSID7068007
ZINC100048699
888P990
W-109220
5,5′-(1H-Isoindole-1,3(2H)-diylidene)di(1,3-diazinane-2,4,6-trione)
Lithol, Fast Yellow 1840
Yellow L1820;pigment yellow 139
36888-99-0 Pigment Yellow 139
Pigment yellow 139 (C.I. 56298)
5,5'-(1H-isoindole-1,3(2H)-diylidene)dibarbituric acid
1,3-Di(2,4,6-trioxohexahydro-5-pyrimidinylidene)isoindole
1,3-Bis(2,4,6-trioxohexahydropyrimidin-5-ylidene)isoindoline
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-(1H-isoindole-1,3(2H)-diylidene)bis-
5,5'-[1,3-Dihydro-2H-isoindole-1,3-diylidene]bis[pyrimidine-2,4,6(1H,3H,5H)-trione]
5-[3-(2,4,6-Trioxo-1,3-diazinan-5-ylidene)isoindol-1-ylidene]-1,3-diazinane-2,4,6-trione
56298
Yellow L1820
pigment yellow 139
Pigment yellow 139 (C.I. 56298)
5,5'-(1H-isoindole-1,3(2H)-diylidene)dibarbituric acid
1,3-Di(2,4,6-trioxohexahydro-5-pyrimidinylidene)isoindole
1,3-Bis(2,4,6-trioxohexahydropyrimidin-5-ylidene)isoindoline
5,5'-(1H-isoindole-1,3(2H)-diylidene)dipyrimidine-2,4,6(1H,3H,5H)-trione
5,5'-[1H-isoindole-1,3-(2H)-diylidene]bis-2,4,6-(1H,3H,5H)Pyrimidinetrione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-(1H-isoindole-1,3(2H)-diylidene)bis-
5-[3-(2,4,6-Trioxo-1,3-diazinan-5-ylidene)isoindol-1-ylidene]-1,3-diazinane-2,4,6-trione
5,5'-(1H-Isoindole-1,3(2H)-diylidene)dibarbituric acid
1,3-Di(2,4,6-trioxohexahydro-5-pyrimidinylidene)isoindole
5-[3-(2,4,6-Trioxo-1,3-diazinan-5-ylidene)isoindol-1-ylidene]-1,3-diazinane-2,4,6-trione
56298
5,5'-[1H-isoindole-1,3-(2H)-diylidene]bis-2,4,6-(1H,3H,5H)Pyrimidinetrione5,5'-(1H-isoindole-1,3(2H)-diylidene)dipyrimidine-2,4,6(1H,3H,5H)-trione
pigment yellow 139
5,5'-(1H-isoindole-1,3(2H)-diylidene)dibarbituric acid
2,4,6(1H,3H,5H)-Pyrimidinetrione
5,5-(1H-isoindole-1,3(2H)-diylidene)bis-
Pigment yellow 139 (C.I. 56298)
1,3-Di(2,4,6-trioxohexahydro-5-pyrimidinylidene)isoindole
5-[3-(2,4,6-Trioxo-1,3-diazinan-5-ylidene)isoindol-1-ylidene]-1,3-diazinane-2,4,6-trione
Yellow L1820
1,3-Bis(2,4,6-trioxohexahydropyrimidin-5-ylidene)isoindoline
CINILEX YELLOW SR 3 CN
Irgazin Yellow K 2060 FP
Isoindolinone of C.I. pigment yellow 139
Paliotol Yellow L 1820
Isoindolinone yellow pigment of C.I. PY 139
Isoindolinone pigment
C.I. PY 139 - 56298, Isoindoline pigment
C.I. PY 139
C.I. Pigment Yellow 139
Isoindolinone yellow pigment, C.I. PY 139
Isoindolinone pigment
C.I. PY 139
Isoindoline yellow
Isoindoline pigment
C.I. PY 139
Pigment Yellow 139
C.I. 56298
C.I. Pigment Yellow 139
CAB-LX 218 Yellow
CF Yellow HM
CFP-FF 293Y
CromophtalYellow 2RT
Fanchon Fast Y 5700
Fanchon Fast Yellow Y 5700
Graphtol Yellow H2R
Inxel Yellow A 101
Irgaphor Yellow 2R-CF
Isoindoline yellow
NovopermYellow M 2R70
PV Fast Yellow H 2R
Paliotol Yellow 1840
PaliotolYellow 2140HD
Paliotol Yellow 2141HK
Paliotol Yellow D 1819
Paliotol YellowK 1841
Paliotol Yellow K 1841D
Paliotol Yellow K 2141HD
Paliotol Yellow L1820
Paliotol Yellow L 1970
Paliotol Yellow L 2140HD
Pigment Yellow 139

PIGMENT YELLOW 14
Pigment Yellow 14 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 14 is a diarylide-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 14 is C34H30Cl2N6O4, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 5468-75-7
EC Number: 226-770-1

Synonyms: Diarylide Yellow 14, Permanent Yellow GR, CI Pigment Yellow 14, Fast Yellow GR, Benzidine Yellow 14, Hansa Yellow 5G, Permanent Yellow G, Azo Yellow, Pigment Yellow GR, Irgazin Yellow GR, Hostaperm Yellow GR, Fast Yellow 14, Hansa Yellow 10G, Hansa Brilliant Yellow 5GX, Benzidine Yellow GR, Fast Light Yellow G, C.I. 21095, Fast Yellow GR, Permanent Yellow 5GX, C.I. Pigment Yellow 14, Permanent Yellow G, Diarylide Yellow GR, Benzidine Yellow 5G, Fast Yellow 5G, Hansa Yellow 10G, Hostaperm Yellow 5G, Irgazin Yellow 5G, Benzidine Yellow G, Permanent Yellow 10G, C.I. Pigment Yellow 5G, Fast Yellow G, Hansa Yellow GR, Benzidine Yellow GX, Permanent Yellow GRX, Hansa Yellow GX, Diarylide Yellow 10G, Benzidine Yellow 10G, Fast Yellow GX, Irgazin Yellow 10G, Hostaperm Yellow GX, Diarylide Yellow G, Hansa Yellow G, Permanent Yellow GX, Benzidine Yellow GRX, Irgazin Yellow GX, Hostaperm Yellow 10G, Permanent Yellow 10GX, C.I. Pigment Yellow GX, C.I. Pigment Yellow 10G



APPLICATIONS


Pigment Yellow 14 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 14 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 14 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 14 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 14 is used in automotive coatings for its excellent durability.
Pigment Yellow 14 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 14 is used in water-based paints for its stability and brightness.
Pigment Yellow 14 is a key component in solvent-based paints and coatings.
Pigment Yellow 14 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 14 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 14 is used in the manufacturing of synthetic fibers.
Pigment Yellow 14 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 14 is used in the creation of artist paints and materials.
Pigment Yellow 14 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 14 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 14 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 14 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 14 is essential in the creation of high-quality printing inks.

Pigment Yellow 14 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 14 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 14 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 14 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 14 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 14 is a key ingredient in the production of plastic colorants.

Pigment Yellow 14 is employed in the textile industry to dye fabrics.
Pigment Yellow 14 is used in the rubber industry for coloring rubber products.
Pigment Yellow 14 is essential in the production of artist materials.

Pigment Yellow 14 is a vital component in water-based and solvent-based systems.
Pigment Yellow 14 is applied in the creation of high-performance industrial products.
Pigment Yellow 14 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 14 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 14 is found in the creation of specialty inks for various applications.
Pigment Yellow 14 is used in the production of ceramic and glass products.

Pigment Yellow 14 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 14 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 14 is essential in the production of coatings for wood surfaces.

Pigment Yellow 14 is used in the formulation of high-performance inks.
Pigment Yellow 14 is applied in the creation of coatings for automotive applications.
Pigment Yellow 14 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 14 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 14 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 14 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 14 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 14 is used in the creation of specialty inks for digital printing.
Pigment Yellow 14 is essential in the production of high-performance industrial products.

Pigment Yellow 14 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 14 is used in the creation of water-based and solvent-based products.
Pigment Yellow 14 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 14 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 14 is a diarylide-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 14 is a versatile organic compound with the chemical formula C34H30Cl2N6O4.
Pigment Yellow 14 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 14 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 14 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 14 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 14 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 14's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 14 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 14 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 14's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 14 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 14 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C34H30Cl2N6O4
Common Name: Pigment Yellow 14
Molecular Structure: C34H30Cl2N6O4
Molecular Weight: 649.55 g/mol
Appearance: Bright yellow powder
Density: 1.5 g/cm³
Melting Point: >300°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 14 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 14.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 14 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 14 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 14 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 14 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
PIGMENT YELLOW 150
DESCRIPTION:
Pigment Yellow 150 is a high-performance pigment.
Pigment Yellow 150 has excellent heat resistance and is very easy to disperse.
Pigment Yellow 150 is used in plastic masterbatch applications.


CAS No. 68511-62-6
European Community (EC) number: 270-944-8
Chemical Name: Pigment Yellow 150

SYNONYMS OF PIGMENT YELLOW 150:
YELLOW 150;pigment yellow 150;Plasco yellow 150;Paintco yellow 150;Fast Yellow Y-5686;C.I. Pigment Yellow 150;68511-62-6 Pigment Yellow 150;5,5’-Azobis[2,4,6-pyrimidinetriol],nickelcomplex;Nickel,5,5’-azobis-2,4,6(1H,3H,5H)-pyrimidinetrionecomplexes;Nickel, 5,5'-(1,2-d iazenediyl)bis[2,4,6(1H,3H,5H)-p yrimidinetrione] complexes; 5,5'-Azobis[2,4,6-pyrimidinetriol], nickel complex; nickel, 5,5'-azobis-2,4,6(1H,3H,5H)-pyrimidinetrione complexes; 5- [5- [2,4,6 (IH, 3H, 5H) -Pyrimidinetrionyl] azo] -2,4,6 (IH, 3H, 5H) -pyrimidinetrione, nickelcomplex; Pigment jaune 4G;

Pigment Yellow 150 is recommended for PVC, PU, RUB, Fiber, EVA, PE paints, water-based decorative paints and water-based inks.
Pigment Yellow 150 is also recommended for PP, PS, PC, PA, UV ink, inkjet and LCD screens.

Pigment Yellow 150 belongs to the heterocyclic azo nickel complex containing pyrimidine ring, giving a darker neutral yellow color and excellent light fastness.
The light fastness of paint samples can reach up to 1/25 standard depth (SD) Grade 7-8, but the light fastness and weather fastness are slightly reduced when diluted.
Pigment Yellow 150 is mainly recommended for the coloring of industrial coatings and printing inks.
The ink samples have good acid/alkali resistance and good color strength.



Pigment Yellow 150 is a green shade Azo Nickel Complex pigment with very good lightfastness and overall fastness properties as well as excellent heat resistance.
Pigment Yellow 150 is the established standard Colour Index for a green shade yellow to be used in waterbased decorative gravure printing inks.

Pigment yellow 150 belongs to the heterocycle azo nickel complex containing a pyrimidine ring.
Pigment Yellow 150 is a very transparent green pigment of nickel nickel nickel complex green color with very good lightfastness and fastness properties.
Pigment Yellow 150 has strong tinting strength and resistance to heat, light and organic solvents.
Having a very reddish hue and good dispersibility.


Pigment Yellow 150 is metal complex pigment with excellent light fastness.
Pigment Yellow 150 is mainly used in coatings and printing inks.

Pigment Yellow 150 is transparent mid-shade yellow pigment with excellent lightfastness, various kinds of polymers application.
Pigment Yellow 150 is recommended for use in spin dyeing polypropylene and polyamide fibers.

In this type of application, the pigment exhibits good heat stability and also good lightfastness and weather fastness.
Under common processing conditions in injection molding, P.Y.150 is likely to react with the zinc sulfide which is often found in polyamide, a tendency which precludes its use in polyamide injection molding.

BENEFITS OF PIGMENT YELLOW 150:
Pigment Yellow 150 has Very good lightfastness and overall fastness properties
Pigment Yellow 150 has Excellent heat resistance



APPLICATIONS OF PIGMENT YELLOW 150:
Pigment Yellow 150 is Recommended for automotive paints, industrial paints, powder coatings, printing pastes, PVC, rubber, PS, PP, PE, PU, water-based inks, solvent-based inks, UV inks.

CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 150:
APPEARANCE

DARK YELLOW POWDER

SHADE

GREENISH

HEAT RESISTANCE

300 °C min

LIGHT FASTNESS

7-8

ACID RESISTANCE

4

ALKALI RESISTANCE

4

FASTNESS TO BLEEDING

5

OIL ABSORPTION

40-45%

SPECIFIC SURFACE

25 m 2 /g

DENSITY

1.80 g/cm 3

RESIDUE ON 80 MESH

5.0% max

WATER SOLUBLE

1.0% max

VOLATITE 105 °C

1.0% max

TINTING STRENGTH

100-105 %

Color index Yellow pigment 150
Product Name Corimax Yellow 150
Product Category Pigment organique
CAS number 68511-62-6/25157-64-6
EU number 270-944-8
Chemical family Mono azo
Molecular weight 282.17
Molecular formula C8H6N6O6
PH 7
Densité 2.0
Oil absorption (ml/100g)% 55
Lightfastness (coating) 7-8
Thermal resistance (coating) 200
Lightfastness (plastic) 7-8
Thermal resistance (plastic) 280
Résistance à l'eau 5
Résistance à l'huile 5
Résistance aux acides 4
Resistance to alkalis 4
Density [g/cm3] 1.85
Specific surface [m2/g] 124
Average particle size [nm] 78
Oil absorption [ml/100g] 64
Product Name PIGMENT YELLOW 150
Synonyms C.I.Pigment Yellow 150; C.I.PY150; PY150; P.Y.150
C.I. 12764
CAS NO. 68511-62-6
EINECS 270-944-8
Molecular Weight 340.86
Molecular Formula C8H6N6O6
Color Yellow powder
CBNumber:
CB7347072
Molecular Formula:
C8H6N6O6
Molecular Weight:
282.17
Physical appearance

Yellow powder

Ombre

Medium

Tinting strength, %

95-105

Density, g/ cm3

2.0

Specific surface area, m2 / g

124

Average particle size

70-80

Oil absorption, g/100g

50

PH

sept

Heat resistance,

280

Lightfastness (8-Excellent, 1-Poor)

8

Acid resistance

4

Resistance to alkalis

4

Water resistance

5

Oil resistance

5

Fastness Properties of Pigment Yellow 150:

Light Fastness 7-8
Heat Resistance(℃) 200
Water Resistance 5
Oil Resistance 4
Acid Resistance 4
Alkali Resistance 4
Alcohol Resistance 3


SAFETY INFORMATION ABOUT PIGMENT YELLOW 150:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.
PIGMENT YELLOW 151
DESCRIPTION:

Pigment Yellow 151 has a greener hue than CI Pigment Yellow 154 and a reddish hue than Pigment Yellow 175.
The hue angle is 97.4 degrees (1/3SD).
The specific surface area of Hostaperm Yellow H4G is 23m2/g, which has good hiding power; light fastness .

CAS NO. 31837-42-0
EINECS 250-830-4


SYNONYMS OF PIGMENT YELLOW 151:
C.I.Pigment Yellow 151; C.I.PY151; PY151; P.Y.151,C.I. PIGMENT YELLOW 151,31837-42-0,PIGMENT YELLOW 151,2-[[1,3-dioxo-1-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]butan-2-yl]diazenyl]benzoic acid,2-[[1-[[(2,3-dihydro-2-oxo-1h-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azo]benzoic acid,2-((1-(((2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)amino)carbonyl)-2-oxopropyl)azo)benzoic acid,EINECS 250-830-4,EC 250-830-4,SCHEMBL1617078,DTXSID60865612,MFCD01940586,Pigment yellow 151, technical grade,Benzoic acid, 2-((1-(((2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino)carbonyl)-2-oxopropyl)azo),Benzoic acid, 2-((1-(((2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino)carbonyl)-2-oxopropyl)azo)-,Benzoic acid, 2-(2-(1-(((2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino)carbonyl)-2-oxopropyl)diazenyl)-,837P420,W-110808,2-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azo]-Benzoicacid,IUPAC Name: 2-[[1,3-dioxo-1-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]butan-2-yl]diazenyl]benzoic acid



The fastness is excellent.
When the sample colored by alkyd melamine resin is exposed to Florida for 1 year, the weather fastness has a grade 5 gray card, and the dilute color (1; 3TiO2) is still grade 4; 1/3 Standard depth HDPE has a heat-resistant stability of 260℃/5min; it is suitable for high-end industrial coatings, automotive primers (OEM), and can be combined with phthalocyanines and inorganic pigments, and can also be used for printing on polyester laminated plastic films Coloring of ink.

Pigment Yellow 151 is known as Benzimidazolone Yellow H4G.
Pigment Yellow 151 has a heat resistance of 280ºC and light fastness of 7-8.
Pigment Yellow 151 is used in high quality applications.
Its C.I. name is Pigment Yellow 151 and the C.I. NO. is 13980.


Pigment yellow 151 is a disazomethine dye with solid-state fluorescence.a biologically active chemical.
Pigment Yellow 151 has high color strength, excellent heat stability, warping resistance.
Pigment Yellow 151 is a very opaque, relatively greenish-yellow shade of Benzimidazolone Yellow pigment with very good dispsersibility, excellent light and heat fastness.

Pigment Yellow 151 has good overall fastness properties, making it a recommended pigment for inks, coatings and plastics applications.
Due to low influence on warpage it works very well for coloration of bottle crates, boxes and cases.

Pigment Yellow 151 is a modified version of Hostaperm Yellow H4G with considerably better opacity, distinctly improved flow properties and with a lighter and cleaner full shade.
Its improved rheological characteristics contribute to increase production economies by permitting to use higher pigment loading in mill base without adversely affecting the gloss.

Pigment Yellow 151 is a greenish shade yellow pigment.
Its shade is greener than Pigment Yellow 154 and redder than Pigment Yellow 175.
PY151 is good in opaque and excellent in light fastness.

In the test of alkyed melamine resin system, the light fastness can be grade 5.
In HDPE test, the heat stability of PY151 can be 260℃/5min.
Pigment Yellow 151 can also be used together with Phthalocyanines and inorganic pigments.

Pigment Yellow 151 is a general use pigment, which can be used in high end OEM paint.
Pigment Yellow 151 has light fastness of 7-8.
Pigment Yellow 151 has excellent high opacity and good flow.
Its heat resistance, acid resistance and ethanol resistance is good.


Pigment Yellow 151 has an excellent light fastness, high weather fastness, high heat resistance and excellent dispersibility. Due to low influence on warpage it works very well for coloration of bottle crates, boxes and cases.

BENEFITS OF PIGMENT YELLOW 151:
Pigment Yellow 151 has FDA compliant in all polymers under condition A-H
Pigment Yellow 151 is Excellent Lead chromate replacement


APPLICATIONS OF PIGMENT YELLOW 151:
Decorative water based paints, decorative solvent based paints, industrial coatings, automotive OEM refinishes, powder coatings, coil coatings, textile printings, printing inks, offset inks, water based inks, NC inks, in-jet inks, plastics, rubbers LLPE, LDPE, HDPE, PP, PVC, PS, ABS, POM.



CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 151:
Product Name PIGMENT YELLOW 151
Synonyms C.I.Pigment Yellow 151; C.I.PY151; PY151; P.Y.151
C.I. 13980
CAS NO. 31837-42-0
EINECS 250-830-4
Molecular Weight 381.34
Molecular Formula C18H15N5O5
Density 1.55g/cm3
Color Yellow powder
Molecular Weight 381.3
XLogP3-AA 1.7
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 6
Exact Mass 381.1073186
Monoisotopic Mass 381.1073186
Topological Polar Surface Area 149 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 681
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
Product name: Benzimidazolone Yellow H4G
Epsilon code: ECY15101
C.I. No.: 13980
Color Index: Pigment Yellow 151
CAS RN NO.: 31837-42-0
EINECS NO.: 250-830-4
Chemical Group: Benzimidazolone
Appearance

Yellow powder

Shade

Greenish

Tinting Strength, %

95-105

Oil Absorption, g/100g

35-45

Heat Resistance, °C

250

Light Fastness

7-8

pH Value

5.0-7.0

Density

1.47

BET Surface Area, m2/g

26

Bleeding Resistance

5

Soap Resistance

5

Acid Resistance

5

Alkali Resistance

5

Alcohol Resistance

5

Ester Resistance

5

Benzene Resistance

5

Ketone Resistance

5

Migration Resistance

5
Density [g/cm³] 1.53
Bulk volume [l/kg] 3.5
Alkali resistance 5
Acid resistance 5
Specific surface [m2/g] 16.1
Low warping applications Limited suitability
Cable sheathing Suitable
Fastness to bleeding in P-PVC 5
Light fastness (Full) : 7-8
Light fastness(Tinting) : 7
Water : 4-5
Ethanol : 5
Heat stability (10min) :260℃
Toluene:5
Acid: 5
Alkali :3-4
Migration:5
Weather:4

Fastness Properties of Pigment Yellow 151:
Light Fastness 6
Heat Resistance(℃) 200
Water Resistance 5
Oil Resistance 4
Acid Resistance 5
Alkali Resistance 5
Alcohol Resistance 5


SAFETY INFORMATION ABOUT PIGMENT YELLOW 151:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.
PIGMENT YELLOW 154
DESCRIPTION:
Pigment Yellow 154 is greenish yellow with a hue angle of 95.1 degrees (1/3SD), but it shows red light compared to CI Pigment Yellow 175 and Pigment Yellow 151.
Pigment Yellow 154 has excellent lightfastness and weatherability, and good solvent resistance.
Thermal stability, mainly used in coatings.

CAS Registry Number:68134-22-5
EINECS NO.: 268-734-6
Molecular Formula:C18H14F3N5O3
Molecular Weight: 405.33

SYNONYMES OF PIGMENT YELLOW 154:
68134-22-5,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]butyramide
EINECS268-734-6,3-oxo-N-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-2-[[2-(trifluorométhyl)phényl]diazényl]butanamide
CE 268-734-6,2-(2-trifluorométhylphénylazo)-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutanamide,Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)-Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-(2-(2-(trifluorométhyl)phényl)diazényl)-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[2-[2-(trifluorométhyl)phényl]diazényl]-,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)butyramide,SCHEMBL3652215,SCHEMBL10299914,DTXSID50867488,C18H14F3N5O3,VBNVBMNKUIJLPP-OCEACIFDSA-N,VBNVBMNKUIJLPP-UHFFFAOYSA-N,HY-D0626,C18-H14-F3-N5-O3,CS-0010717




Pigment Yellow 154 is one of the most lightfast and weatherproof yellow varieties.

Pigment Yellow 154 is mainly recommended for metallic decorative paints and automotive coatings (OEM).
Pigment Yellow 154 has good rheology so that it does not affect its gloss at high concentrations; Pigment Yellow 154 can also be used for coloring and coloring of rigid PVC plastic outdoor products; HDPE heat-resistant stability is 210℃/5min; suitable for printing inks that require high lightfastness

Pigment Yellow 154 is a pigment with a medium yellow shade and outstanding fastness to light and weathering.
Because of its excellent fastness, Pigment Yellow 154 is suitable for use in all concentration ranges down to very pale pastel shades and as a shading pigment.

Pigment Yellow 154 is medium shade yellow pigment with excellent weather fastness, High Tinting strength and good over spray resistance meant for coating application.

Pigment Yellow 154 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent, Good heat stability.
Pigment Yellow 154 which was introduced in the mid-seventies, affords a somewhat greenish yellow shade of very high lightfastness and weatherfastness.

Pigment Yellow 154 is a Benzimidazolone pigments with color index number Pigment yellow 154 (PY154).
Pigment Yellow 154 is a Benzimidazolone yellow, with outstanding lightfastness, excellent solvent stability, opaque, Yellow 1619 is recommended for use in Various paints such for auto paints, industrial paints, solvent paints, etc.

Pigment Yellow 154 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent.
Pigment Yellow 154 has Good heat stability.
Pigment Yellow 154 is Usually recommended for high-grade coating.

Pigment Yellow 154 is a fluorescent dye.
Pigment Yellow 154 can be used as biological dye.

Pigment Yellow 154 is greenish shade yellow pigment powder.
But it is redder than pigment yellow 151.
Pigment Yellow 154 is one of the yellow pigment with best light fastness and weather fastness.

The good flow of Pigment Yellow 154 makes the gloss not affected at high concentration, and is recommended to use in metal decorative paint and automotive paint.
Pigment Yellow 154 is also used in the coloring of soft and rigid PVC.
And the heat stability of Pigment Yellow 154 is HDPE is 210℃/5min.



APPLICATIONS OF PIGMENT YELLOW 154:
Recommended for automotive paints, architectural coatings, coil coatings, industrial paints, powder coatings, printing pastes, water-based inks, solvent inks, UV inks.
Pigment Yellow 154 gives light green yellow, hue angle 95.1 degrees (1/3SD), but it shows red light than CI Pigment Yellow 175, Pigment Yellow 151, and has excellent light fastness, weather resistance and solvent resistance.

Thermal stability, mainly used in coatings.
Pigment Yellow 154 is one of the most light fast and weather resistant yellow varieties.
Pigment Yellow 154 is mainly recommended for metallic decorative paints and automotive coatings (OEM).

Its good rheology does not affect its gloss at high concentrations; Pigment Yellow 154 can also be used for coloring soft and rigid PVC plastic outdoor products; heat resistance in HDPE is 210℃/5min; suitable for printing inks that require high light fastness (printing sample 1/25SD fast 6-7).

Decorative water based paints, decorative solvent based paints, industrial coatings, automotive OEM refinishes, powder coatings, textile printings, offset inks, water based inks, solvent based inks, plastics, rubbers.


BENEFITS OF PIGMENT YELLOW 154:
Pigment Yellow 154 has Very good weather fastness
Pigment Yellow 154 is Easy to disperse in water-based paint systems
Pigment Yellow 154 Improved finishing process with better ecological footprint


CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 154:

Nom de la propriété Property value
Molecular weight 405,3 g/mole
XLogP3-AA 3.1
Number of hydrogen bond donors 3
Number of hydrogen bond acceptors 8
Number of rotary links 5
Exact mass 405,10487381 g/mole
Monoisotopic mass 405,10487381 g/mole
Topological polar surface 112Ų
Number of heavy atoms 29
Charge formal 0
Complexité 684
Number of isotopic atoms 0
Number of stereocenters of atoms defined 0
Number of atomic stereocenters not defined 1
Number of defined binding stereocenters 0
Number of binding stereocenters not defined 0
Number of covalently bonded units 1
The compound is canonized Oui


Color index Yellow pigment 154
Product Name Corimax Yellow H3G
Product Category Pigment organique
CAS number 68134-22-5
EU number 268-734-6
Chemical family Benzimidazolone
Molecular weight 405.33
Molecular formula C18H14F3N5O3
PH 7
Densité 1.6
Oil absorption (ml/100g)% 45-55
Lightfastness (coating) 7
Thermal resistance (coating) 180
Résistance à l'eau 5
Résistance à l'huile 5
Résistance aux acides 5
Resistance to alkalis 5
Product Name YELLOW PIGMENT 154
Synonymes CIPigment Yellow 154; CIPY154; PY154; PY154
THIS 11781
CAS No. 68134-22-5
EINECS 268-734-6
Molecular weight 405.33
Molecular formula C18H14F3N5O3
Densité 1.52g/cm3
Couleur Yellow powder
Appearance

Yellow powder

Shade

Greenish

Tinting Strength, %

95-105

Oil Absorption, g/100g

35-45

Heat Resistance, °C

250

Light Fastness

7-8

pH Value

5.0-7.0

Density

1.47

BET Surface Area, m2/g

26

Bleeding Resistance

5

Soap Resistance

5

Acid Resistance

5

Alkali Resistance

5

Alcohol Resistance

5

Ester Resistance

5

Benzene Resistance

5

Ketone Resistance

5

Migration Resistance

5
Fastness properties of Pigment Yellow 154:

Lightfastness 7
Heat resistance (℃) 180
Water resistance 5
Oil resistance 5
Acid resistance 5
Resistance to alkalis 5
Alcohol resistance 5
Density(g/cm3)
1.6

Moisture (%)
≤0.5

Water Soluble Matter
≤1.0

Oil Absorption (ml / 100g)
45-55

Electric conductivity (us/cm)
≤500

Fineness(80mesh)
≤5.0

PH value
6.5-7.5

Density [g/cm3] 1.54
Form of Supply powder
Specific surface [m2/g] 22
Oil absorption [ml/100g] 56
Avg. Size of Primary Particles [nm] 275
pH value 7.2
Conductivity [mS/cm] 0.09



SAFETY INFORMATION ABOUT PIGMENT YELLOW 154:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.


PIGMENT YELLOW 155
DESCRIPTION:
PIGMENT YELLOW 155 is greenish yellow with a hue angle of 95.1 degrees (1/3SD), but it shows red light compared to CI Pigment Yellow 175 and Pigment Yellow 151.
PIGMENT YELLOW 155 has excellent lightfastness and weatherability, and good solvent resistance.
Thermal stability, mainly used in coatings.

CAS Registry Number: 68516-73-4
EINECS NO.: 271-176-6
Molecular Formula:C18H14F3N5O3
Molecular Weight: 405.33

SYNONYMES OF PIGMENT YELLOW 155:
68134-22-5,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]butyramide
EINECS 271-176-6,3-oxo-N-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-2-[[2-(trifluorométhyl)phényl]diazényl]butanamide
CE 268-734-6,2-(2-trifluorométhylphénylazo)-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutanamide,Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)-Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-(2-(2-(trifluorométhyl)phényl)diazényl)-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[2-[2-(trifluorométhyl)phényl]diazényl]-,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)butyramide,SCHEMBL3652215,SCHEMBL10299914,DTXSID50867488,C18H14F3N5O3,VBNVBMNKUIJLPP-OCEACIFDSA-N,VBNVBMNKUIJLPP-UHFFFAOYSA-N,HY-D0626,C18-H14-F3-N5-O3,CS-0010717




PIGMENT YELLOW 155 is one of the most lightfast and weatherproof yellow varieties.

PIGMENT YELLOW 155 is mainly recommended for metallic decorative paints and automotive coatings (OEM).
PIGMENT YELLOW 155 has good rheology so that it does not affect its gloss at high concentrations; PIGMENT YELLOW 155 can also be used for coloring and coloring of rigid PVC plastic outdoor products; HDPE heat-resistant stability is 210℃/5min; suitable for printing inks that require high lightfastness

PIGMENT YELLOW 155 is a pigment with a medium yellow shade and outstanding fastness to light and weathering.
Because of its excellent fastness, PIGMENT YELLOW 155 is suitable for use in all concentration ranges down to very pale pastel shades and as a shading pigment.

PIGMENT YELLOW 155 is medium shade yellow pigment with excellent weather fastness, High Tinting strength and good over spray resistance meant for coating application.

PIGMENT YELLOW 155 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent, Good heat stability.
PIGMENT YELLOW 155 which was introduced in the mid-seventies, affords a somewhat greenish yellow shade of very high lightfastness and weatherfastness.

PIGMENT YELLOW 155 is a Benzimidazolone pigments with color index number PIGMENT YELLOW 155 (PY154).
PIGMENT YELLOW 155 is a Benzimidazolone yellow, with outstanding lightfastness, excellent solvent stability, opaque, Yellow 1619 is recommended for use in Various paints such for auto paints, industrial paints, solvent paints, etc.

PIGMENT YELLOW 155 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent.
PIGMENT YELLOW 155 has Good heat stability.
PIGMENT YELLOW 155 is Usually recommended for high-grade coating.

PIGMENT YELLOW 155 is a fluorescent dye.
PIGMENT YELLOW 155 can be used as biological dye.

PIGMENT YELLOW 155 is greenish shade yellow pigment powder.
But it is redder than pigment yellow 151.
PIGMENT YELLOW 155 is one of the yellow pigment with best light fastness and weather fastness.

The good flow of PIGMENT YELLOW 155 makes the gloss not affected at high concentration, and is recommended to use in metal decorative paint and automotive paint.
PIGMENT YELLOW 155 is also used in the coloring of soft and rigid PVC.
And the heat stability of PIGMENT YELLOW 155 is HDPE is 210℃/5min.



APPLICATIONS OF PIGMENT YELLOW 155:
Recommended for automotive paints, architectural coatings, coil coatings, industrial paints, powder coatings, printing pastes, water-based inks, solvent inks, UV inks.
PIGMENT YELLOW 155 gives light green yellow, hue angle 95.1 degrees (1/3SD), but it shows red light than CI Pigment Yellow 175, Pigment Yellow 151, and has excellent light fastness, weather resistance and solvent resistance.

Thermal stability, mainly used in coatings.
PIGMENT YELLOW 155 is one of the most light fast and weather resistant yellow varieties.
PIGMENT YELLOW 155 is mainly recommended for metallic decorative paints and automotive coatings (OEM).

Its good rheology does not affect its gloss at high concentrations; PIGMENT YELLOW 155 can also be used for coloring soft and rigid PVC plastic outdoor products; heat resistance in HDPE is 210℃/5min; suitable for printing inks that require high light fastness (printing sample 1/25SD fast 6-7).

Decorative water based paints, decorative solvent based paints, industrial coatings, automotive OEM refinishes, powder coatings, textile printings, offset inks, water based inks, solvent based inks, plastics, rubbers.


BENEFITS OF PIGMENT YELLOW 155:
PIGMENT YELLOW 155 has Very good weather fastness
PIGMENT YELLOW 155 is Easy to disperse in water-based paint systems
PIGMENT YELLOW 155 Improved finishing process with better ecological footprint


CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 155:

Nom de la propriété Property value
Molecular weight 405,3 g/mole
XLogP3-AA 3.1
Number of hydrogen bond donors 3
Number of hydrogen bond acceptors 8
Number of rotary links 5
Exact mass 405,10487381 g/mole
Monoisotopic mass 405,10487381 g/mole
Topological polar surface 112Ų
Number of heavy atoms 29
Charge formal 0
Complexité 684
Number of isotopic atoms 0
Number of stereocenters of atoms defined 0
Number of atomic stereocenters not defined 1
Number of defined binding stereocenters 0
Number of binding stereocenters not defined 0
Number of covalently bonded units 1
The compound is canonized Oui


Color index Yellow pigment 154
Product Name Corimax Yellow H3G
Product Category Pigment organique
CAS number 68516-73-4
EU number 268-734-6
Chemical family Benzimidazolone
Molecular weight 405.33
Molecular formula C18H14F3N5O3
PH 7
Densité 1.6
Oil absorption (ml/100g)% 45-55
Lightfastness (coating) 7
Thermal resistance (coating) 180
Résistance à l'eau 5
Résistance à l'huile 5
Résistance aux acides 5
Resistance to alkalis 5
Product Name YELLOW PIGMENT 154
Synonymes CIPIGMENT YELLOW 155; CIPY154; PY154; PY154
THIS 11781
CAS No. 68516-73-4
EINECS 271-176-6
Molecular weight 405.33
Molecular formula C18H14F3N5O3
Densité 1.52g/cm3
Couleur Yellow powder
Appearance

Yellow powder

Shade

Greenish

Tinting Strength, %

95-105

Oil Absorption, g/100g

35-45

Heat Resistance, °C

250

Light Fastness

7-8

pH Value

5.0-7.0

Density

1.47

BET Surface Area, m2/g

26

Bleeding Resistance

5

Soap Resistance

5

Acid Resistance

5

Alkali Resistance

5

Alcohol Resistance

5

Ester Resistance

5

Benzene Resistance

5

Ketone Resistance

5

Migration Resistance

5
Fastness properties of PIGMENT YELLOW 155:

Lightfastness 7
Heat resistance (℃) 180
Water resistance 5
Oil resistance 5
Acid resistance 5
Resistance to alkalis 5
Alcohol resistance 5
Density(g/cm3)
1.6

Moisture (%)
≤0.5

Water Soluble Matter
≤1.0

Oil Absorption (ml / 100g)
45-55

Electric conductivity (us/cm)
≤500

Fineness(80mesh)
≤5.0

PH value
6.5-7.5

Density [g/cm3] 1.54
Form of Supply powder
Specific surface [m2/g] 22
Oil absorption [ml/100g] 56
Avg. Size of Primary Particles [nm] 275
pH value 7.2
Conductivity [mS/cm] 0.09



SAFETY INFORMATION ABOUT PIGMENT YELLOW 155:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.


PIGMENT YELLOW 17

Pigment Yellow 17 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 17 is a monoazo-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 17 is C18H17N3O3, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 4531-49-1
EC Number: 224-866-6

Synonyms: Monoazo Yellow 17, Permanent Yellow 2G, CI Pigment Yellow 17, Fast Yellow 2G, Hansa Yellow 17, Permanent Yellow 17, Benzidine Yellow 17, Hansa Yellow 2G, Irgazin Yellow 2G, Hostaperm Yellow 2G, Fast Yellow 17, Benzidine Yellow G, Hansa Yellow G, Diarylide Yellow 2G, CI 21105, Fast Light Yellow 17, Permanent Yellow G, Hansa Brilliant Yellow 2GX, Fast Yellow G, Hansa Yellow GX, Hostaperm Yellow 17, Permanent Yellow 17G, Irgazin Yellow 17G, Benzidine Yellow GX, Hostaperm Yellow G, Fast Yellow GX, Permanent Yellow GX, Benzidine Yellow G, Diarylide Yellow G, Permanent Yellow 2GX, Fast Yellow 2G, Permanent Yellow G, Fast Yellow G, Hansa Yellow GX, Benzidine Yellow GX, Hostaperm Yellow GX, Permanent Yellow 2GX, CI Pigment Yellow 2G, Irgazin Yellow G, Fast Yellow GX, Hansa Yellow G, Permanent Yellow GX, CI Pigment Yellow G



APPLICATIONS


Pigment Yellow 17 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 17 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 17 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 17 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 17 is used in automotive coatings for its excellent durability.
Pigment Yellow 17 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 17 is used in water-based paints for its stability and brightness.
Pigment Yellow 17 is a key component in solvent-based paints and coatings.
Pigment Yellow 17 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 17 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 17 is used in the manufacturing of synthetic fibers.
Pigment Yellow 17 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 17 is used in the creation of artist paints and materials.
Pigment Yellow 17 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 17 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 17 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 17 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 17 is essential in the creation of high-quality printing inks.

Pigment Yellow 17 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 17 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 17 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 17 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 17 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 17 is a key ingredient in the production of plastic colorants.

Pigment Yellow 17 is employed in the textile industry to dye fabrics.
Pigment Yellow 17 is used in the rubber industry for coloring rubber products.
Pigment Yellow 17 is essential in the production of artist materials.

Pigment Yellow 17 is a vital component in water-based and solvent-based systems.
Pigment Yellow 17 is applied in the creation of high-performance industrial products.
Pigment Yellow 17 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 17 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 17 is found in the creation of specialty inks for various applications.
Pigment Yellow 17 is used in the production of ceramic and glass products.

Pigment Yellow 17 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 17 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 17 is essential in the production of coatings for wood surfaces.

Pigment Yellow 17 is used in the formulation of high-performance inks.
Pigment Yellow 17 is applied in the creation of coatings for automotive applications.
Pigment Yellow 17 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 17 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 17 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 17 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 17 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 17 is used in the creation of specialty inks for digital printing.
Pigment Yellow 17 is essential in the production of high-performance industrial products.

Pigment Yellow 17 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 17 is used in the creation of water-based and solvent-based products.
Pigment Yellow 17 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 17 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 17 is a monoazo-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 17 is a versatile organic compound with the chemical formula C18H17N3O3.
Pigment Yellow 17 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 17 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 17 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 17 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 17 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 17's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 17 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 17 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 17's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 17 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 17 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C18H17N3O3
Common Name: Pigment Yellow 17
Molecular Structure: C18H17N3O3
Molecular Weight: 323.35 g/mol
Appearance: Bright yellow powder
Density: 1.5 g/cm³
Melting Point: >300°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 17 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 17.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 17 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 17 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 17 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 17 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
PIGMENT YELLOW 170
DESCRIPTION:
PIGMENT YELLOW 170 is greenish yellow with a hue angle of 95.1 degrees (1/3SD), but it shows red light compared to CI Pigment Yellow 175 and Pigment Yellow 151.
PIGMENT YELLOW 170 has excellent lightfastness and weatherability, and good solvent resistance.
Thermal stability, mainly used in coatings.

CAS Registry Number: 31775-16-3
EINECS NO.: 250-797-6
Molecular Formula:C18H14F3N5O3
Molecular Weight: 405.33

SYNONYMES OF PIGMENT YELLOW 170:
68134-22-5,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]butyramide
EINECS 250-797-6,3-oxo-N-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-2-[[2-(trifluorométhyl)phényl]diazényl]butanamide
CE 268-734-6,2-(2-trifluorométhylphénylazo)-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutanamide,Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)-Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-(2-(2-(trifluorométhyl)phényl)diazényl)-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[2-[2-(trifluorométhyl)phényl]diazényl]-,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)butyramide,SCHEMBL3652215,SCHEMBL10299914,DTXSID50867488,C18H14F3N5O3,VBNVBMNKUIJLPP-OCEACIFDSA-N,VBNVBMNKUIJLPP-UHFFFAOYSA-N,HY-D0626,C18-H14-F3-N5-O3,CS-0010717




PIGMENT YELLOW 170 is one of the most lightfast and weatherproof yellow varieties.

PIGMENT YELLOW 170 is mainly recommended for metallic decorative paints and automotive coatings (OEM).
PIGMENT YELLOW 170 has good rheology so that it does not affect its gloss at high concentrations; PIGMENT YELLOW 170 can also be used for coloring and coloring of rigid PVC plastic outdoor products; HDPE heat-resistant stability is 210℃/5min; suitable for printing inks that require high lightfastness

PIGMENT YELLOW 170 is a pigment with a medium yellow shade and outstanding fastness to light and weathering.
Because of its excellent fastness, PIGMENT YELLOW 170 is suitable for use in all concentration ranges down to very pale pastel shades and as a shading pigment.

PIGMENT YELLOW 170 is medium shade yellow pigment with excellent weather fastness, High Tinting strength and good over spray resistance meant for coating application.

PIGMENT YELLOW 170 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent, Good heat stability.
PIGMENT YELLOW 170 which was introduced in the mid-seventies, affords a somewhat greenish yellow shade of very high lightfastness and weatherfastness.

PIGMENT YELLOW 170 is a Benzimidazolone pigments with color index number PIGMENT YELLOW 170 (PY154).
PIGMENT YELLOW 170 is a Benzimidazolone yellow, with outstanding lightfastness, excellent solvent stability, opaque, Yellow 1619 is recommended for use in Various paints such for auto paints, industrial paints, solvent paints, etc.

PIGMENT YELLOW 170 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent.
PIGMENT YELLOW 170 has Good heat stability.
PIGMENT YELLOW 170 is Usually recommended for high-grade coating.

PIGMENT YELLOW 170 is a fluorescent dye.
PIGMENT YELLOW 170 can be used as biological dye.

PIGMENT YELLOW 170 is greenish shade yellow pigment powder.
But it is redder than pigment yellow 151.
PIGMENT YELLOW 170 is one of the yellow pigment with best light fastness and weather fastness.

The good flow of PIGMENT YELLOW 170 makes the gloss not affected at high concentration, and is recommended to use in metal decorative paint and automotive paint.
PIGMENT YELLOW 170 is also used in the coloring of soft and rigid PVC.
And the heat stability of PIGMENT YELLOW 170 is HDPE is 210℃/5min.



APPLICATIONS OF PIGMENT YELLOW 170:
Recommended for automotive paints, architectural coatings, coil coatings, industrial paints, powder coatings, printing pastes, water-based inks, solvent inks, UV inks.
PIGMENT YELLOW 170 gives light green yellow, hue angle 95.1 degrees (1/3SD), but it shows red light than CI Pigment Yellow 175, Pigment Yellow 151, and has excellent light fastness, weather resistance and solvent resistance.

Thermal stability, mainly used in coatings.
PIGMENT YELLOW 170 is one of the most light fast and weather resistant yellow varieties.
PIGMENT YELLOW 170 is mainly recommended for metallic decorative paints and automotive coatings (OEM).

Its good rheology does not affect its gloss at high concentrations; PIGMENT YELLOW 170 can also be used for coloring soft and rigid PVC plastic outdoor products; heat resistance in HDPE is 210℃/5min; suitable for printing inks that require high light fastness (printing sample 1/25SD fast 6-7).

Decorative water based paints, decorative solvent based paints, industrial coatings, automotive OEM refinishes, powder coatings, textile printings, offset inks, water based inks, solvent based inks, plastics, rubbers.


BENEFITS OF PIGMENT YELLOW 170:
PIGMENT YELLOW 170 has Very good weather fastness
PIGMENT YELLOW 170 is Easy to disperse in water-based paint systems
PIGMENT YELLOW 170 Improved finishing process with better ecological footprint


CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 170:

Nom de la propriété Property value
Molecular weight 405,3 g/mole
XLogP3-AA 3.1
Number of hydrogen bond donors 3
Number of hydrogen bond acceptors 8
Number of rotary links 5
Exact mass 405,10487381 g/mole
Monoisotopic mass 405,10487381 g/mole
Topological polar surface 112Ų
Number of heavy atoms 29
Charge formal 0
Complexité 684
Number of isotopic atoms 0
Number of stereocenters of atoms defined 0
Number of atomic stereocenters not defined 1
Number of defined binding stereocenters 0
Number of binding stereocenters not defined 0
Number of covalently bonded units 1
The compound is canonized Oui


Color index Yellow pigment 154
Product Name Corimax Yellow H3G
Product Category Pigment organique
CAS number 31775-16-3
EU number 268-734-6
Chemical family Benzimidazolone
Molecular weight 405.33
Molecular formula C18H14F3N5O3
PH 7
Densité 1.6
Oil absorption (ml/100g)% 45-55
Lightfastness (coating) 7
Thermal resistance (coating) 180
Résistance à l'eau 5
Résistance à l'huile 5
Résistance aux acides 5
Resistance to alkalis 5
Product Name YELLOW PIGMENT 154
Synonymes CIPIGMENT YELLOW 170; CIPY154; PY154; PY154
THIS 11781
CAS No. 31775-16-3
EINECS 250-797-6
Molecular weight 405.33
Molecular formula C18H14F3N5O3
Densité 1.52g/cm3
Couleur Yellow powder
Appearance

Yellow powder

Shade

Greenish

Tinting Strength, %

95-105

Oil Absorption, g/100g

35-45

Heat Resistance, °C

250

Light Fastness

7-8

pH Value

5.0-7.0

Density

1.47

BET Surface Area, m2/g

26

Bleeding Resistance

5

Soap Resistance

5

Acid Resistance

5

Alkali Resistance

5

Alcohol Resistance

5

Ester Resistance

5

Benzene Resistance

5

Ketone Resistance

5

Migration Resistance

5
Fastness properties of PIGMENT YELLOW 170:

Lightfastness 7
Heat resistance (℃) 180
Water resistance 5
Oil resistance 5
Acid resistance 5
Resistance to alkalis 5
Alcohol resistance 5
Density(g/cm3)
1.6

Moisture (%)
≤0.5

Water Soluble Matter
≤1.0

Oil Absorption (ml / 100g)
45-55

Electric conductivity (us/cm)
≤500

Fineness(80mesh)
≤5.0

PH value
6.5-7.5

Density [g/cm3] 1.54
Form of Supply powder
Specific surface [m2/g] 22
Oil absorption [ml/100g] 56
Avg. Size of Primary Particles [nm] 275
pH value 7.2
Conductivity [mS/cm] 0.09



SAFETY INFORMATION ABOUT PIGMENT YELLOW 170:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



PIGMENT YELLOW 181
DESCRIPTION:
PIGMENT YELLOW 181 is greenish yellow with a hue angle of 95.1 degrees (1/3SD), but it shows red light compared to CI Pigment Yellow 175 and Pigment Yellow 151.
PIGMENT YELLOW 181 has excellent lightfastness and weatherability, and good solvent resistance.
Thermal stability, mainly used in coatings.

CAS Registry Number: 74441-05-7
EINECS NO.: 277-873-1
Molecular Formula:C25H21N7O5
Molecular Weight: 499.48

SYNONYMES OF PIGMENT YELLOW 181:
68134-22-5,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]butyramide
EINECS 277-873-1,3-oxo-N-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-2-[[2-(trifluorométhyl)phényl]diazényl]butanamide
CE 268-734-6,2-(2-trifluorométhylphénylazo)-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutanamide,Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)-Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-(2-(2-(trifluorométhyl)phényl)diazényl)-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[2-[2-(trifluorométhyl)phényl]diazényl]-,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)butyramide,SCHEMBL3652215,SCHEMBL10299914,DTXSID50867488,C25H21N7O5,VBNVBMNKUIJLPP-OCEACIFDSA-N,VBNVBMNKUIJLPP-UHFFFAOYSA-N,HY-D0626,C18-H14-F3-N5-O3,CS-0010717




PIGMENT YELLOW 181 is one of the most lightfast and weatherproof yellow varieties.

PIGMENT YELLOW 181 is mainly recommended for metallic decorative paints and automotive coatings (OEM).
PIGMENT YELLOW 181 has good rheology so that it does not affect its gloss at high concentrations; PIGMENT YELLOW 181 can also be used for coloring and coloring of rigid PVC plastic outdoor products; HDPE heat-resistant stability is 210℃/5min; suitable for printing inks that require high lightfastness

PIGMENT YELLOW 181 is a pigment with a medium yellow shade and outstanding fastness to light and weathering.
Because of its excellent fastness, PIGMENT YELLOW 181 is suitable for use in all concentration ranges down to very pale pastel shades and as a shading pigment.

PIGMENT YELLOW 181 is medium shade yellow pigment with excellent weather fastness, High Tinting strength and good over spray resistance meant for coating application.

PIGMENT YELLOW 181 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent, Good heat stability.
PIGMENT YELLOW 181 which was introduced in the mid-seventies, affords a somewhat greenish yellow shade of very high lightfastness and weatherfastness.

PIGMENT YELLOW 181 is a Benzimidazolone pigments with color index number PIGMENT YELLOW 181 (PY154).
PIGMENT YELLOW 181 is a Benzimidazolone yellow, with outstanding lightfastness, excellent solvent stability, opaque, Yellow 1619 is recommended for use in Various paints such for auto paints, industrial paints, solvent paints, etc.

PIGMENT YELLOW 181 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent.
PIGMENT YELLOW 181 has Good heat stability.
PIGMENT YELLOW 181 is Usually recommended for high-grade coating.

PIGMENT YELLOW 181 is a fluorescent dye.
PIGMENT YELLOW 181 can be used as biological dye.

PIGMENT YELLOW 181 is greenish shade yellow pigment powder.
But it is redder than pigment yellow 151.
PIGMENT YELLOW 181 is one of the yellow pigment with best light fastness and weather fastness.

The good flow of PIGMENT YELLOW 181 makes the gloss not affected at high concentration, and is recommended to use in metal decorative paint and automotive paint.
PIGMENT YELLOW 181 is also used in the coloring of soft and rigid PVC.
And the heat stability of PIGMENT YELLOW 181 is HDPE is 210℃/5min.



APPLICATIONS OF PIGMENT YELLOW 181:
Recommended for automotive paints, architectural coatings, coil coatings, industrial paints, powder coatings, printing pastes, water-based inks, solvent inks, UV inks.
PIGMENT YELLOW 181 gives light green yellow, hue angle 95.1 degrees (1/3SD), but it shows red light than CI Pigment Yellow 175, Pigment Yellow 151, and has excellent light fastness, weather resistance and solvent resistance.

Thermal stability, mainly used in coatings.
PIGMENT YELLOW 181 is one of the most light fast and weather resistant yellow varieties.
PIGMENT YELLOW 181 is mainly recommended for metallic decorative paints and automotive coatings (OEM).

Its good rheology does not affect its gloss at high concentrations; PIGMENT YELLOW 181 can also be used for coloring soft and rigid PVC plastic outdoor products; heat resistance in HDPE is 210℃/5min; suitable for printing inks that require high light fastness (printing sample 1/25SD fast 6-7).

Decorative water based paints, decorative solvent based paints, industrial coatings, automotive OEM refinishes, powder coatings, textile printings, offset inks, water based inks, solvent based inks, plastics, rubbers.


BENEFITS OF PIGMENT YELLOW 181:
PIGMENT YELLOW 181 has Very good weather fastness
PIGMENT YELLOW 181 is Easy to disperse in water-based paint systems
PIGMENT YELLOW 181 Improved finishing process with better ecological footprint


CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 181:

Nom de la propriété Property value
Molecular weight 405,3 g/mole
XLogP3-AA 3.1
Number of hydrogen bond donors 3
Number of hydrogen bond acceptors 8
Number of rotary links 5
Exact mass 405,10487381 g/mole
Monoisotopic mass 405,10487381 g/mole
Topological polar surface 112Ų
Number of heavy atoms 29
Charge formal 0
Complexité 684
Number of isotopic atoms 0
Number of stereocenters of atoms defined 0
Number of atomic stereocenters not defined 1
Number of defined binding stereocenters 0
Number of binding stereocenters not defined 0
Number of covalently bonded units 1
The compound is canonized Oui


Color index Yellow pigment 154
Product Name Corimax Yellow H3G
Product Category Pigment organique
CAS number 74441-05-7
EU number 268-734-6
Chemical family Benzimidazolone
Molecular weight 499.48
Molecular formula C25H21N7O5
PH 7
Densité 1.6
Oil absorption (ml/100g)% 45-55
Lightfastness (coating) 7
Thermal resistance (coating) 180
Résistance à l'eau 5
Résistance à l'huile 5
Résistance aux acides 5
Resistance to alkalis 5
Product Name YELLOW PIGMENT 154
Synonymes CIPIGMENT YELLOW 181; CIPY154; PY154; PY154
THIS 11781
CAS No. 74441-05-7
EINECS 277-873-1
Molecular weight 499.48
Molecular formula C25H21N7O5
Densité 1.52g/cm3
Couleur Yellow powder
Appearance

Yellow powder

Shade

Greenish

Tinting Strength, %

95-105

Oil Absorption, g/100g

35-45

Heat Resistance, °C

250

Light Fastness

7-8

pH Value

5.0-7.0

Density

1.47

BET Surface Area, m2/g

26

Bleeding Resistance

5

Soap Resistance

5

Acid Resistance

5

Alkali Resistance

5

Alcohol Resistance

5

Ester Resistance

5

Benzene Resistance

5

Ketone Resistance

5

Migration Resistance

5
Fastness properties of PIGMENT YELLOW 181:

Lightfastness 7
Heat resistance (℃) 180
Water resistance 5
Oil resistance 5
Acid resistance 5
Resistance to alkalis 5
Alcohol resistance 5
Density(g/cm3)
1.6

Moisture (%)
≤0.5

Water Soluble Matter
≤1.0

Oil Absorption (ml / 100g)
45-55

Electric conductivity (us/cm)
≤500

Fineness(80mesh)
≤5.0

PH value
6.5-7.5

Density [g/cm3] 1.54
Form of Supply powder
Specific surface [m2/g] 22
Oil absorption [ml/100g] 56
Avg. Size of Primary Particles [nm] 275
pH value 7.2
Conductivity [mS/cm] 0.09



SAFETY INFORMATION ABOUT PIGMENT YELLOW 181:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.


PIGMENT YELLOW 194
DESCRIPTION:
PIGMENT YELLOW 194 is greenish yellow with a hue angle of 95.1 degrees (1/3SD), but it shows red light compared to CI Pigment Yellow 175 and Pigment Yellow 151.
PIGMENT YELLOW 194 has excellent lightfastness and weatherability, and good solvent resistance.
Thermal stability, mainly used in coatings.

CAS Registry Number: 82199-12-0
EINECS NO.: 279-914-9
Molecular Formula:C18H17N5O4
Molecular Weight: 367.36

SYNONYMES OF PIGMENT YELLOW 194:
68134-22-5,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]butyramide
EINECS 279-914-9,3-oxo-N-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-2-[[2-(trifluorométhyl)phényl]diazényl]butanamide
CE 268-734-6,2-(2-trifluorométhylphénylazo)-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutanamide,Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)-Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-(2-(2-(trifluorométhyl)phényl)diazényl)-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluorométhyl)phényl]azo]-
Butanamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[2-[2-(trifluorométhyl)phényl]diazényl]-,N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-((2-(trifluorométhyl)phényl)azo)butyramide,SCHEMBL3652215,SCHEMBL10299914,DTXSID50867488,C18H17N5O4,VBNVBMNKUIJLPP-OCEACIFDSA-N,VBNVBMNKUIJLPP-UHFFFAOYSA-N,HY-D0626,C18-H14-F3-N5-O3,CS-0010717




PIGMENT YELLOW 194 is one of the most lightfast and weatherproof yellow varieties.

PIGMENT YELLOW 194 is mainly recommended for metallic decorative paints and automotive coatings (OEM).
PIGMENT YELLOW 194 has good rheology so that it does not affect its gloss at high concentrations; PIGMENT YELLOW 194 can also be used for coloring and coloring of rigid PVC plastic outdoor products; HDPE heat-resistant stability is 210℃/5min; suitable for printing inks that require high lightfastness

PIGMENT YELLOW 194 is a pigment with a medium yellow shade and outstanding fastness to light and weathering.
Because of its excellent fastness, PIGMENT YELLOW 194 is suitable for use in all concentration ranges down to very pale pastel shades and as a shading pigment.

PIGMENT YELLOW 194 is medium shade yellow pigment with excellent weather fastness, High Tinting strength and good over spray resistance meant for coating application.

PIGMENT YELLOW 194 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent, Good heat stability.
PIGMENT YELLOW 194 which was introduced in the mid-seventies, affords a somewhat greenish yellow shade of very high lightfastness and weatherfastness.

PIGMENT YELLOW 194 is a Benzimidazolone pigments with color index number PIGMENT YELLOW 194 (PY154).
PIGMENT YELLOW 194 is a Benzimidazolone yellow, with outstanding lightfastness, excellent solvent stability, opaque, Yellow 1619 is recommended for use in Various paints such for auto paints, industrial paints, solvent paints, etc.

PIGMENT YELLOW 194 is a Benzimidazolone greenish yellow pigment, with excellent light fastness, weather fastness and solvent.
PIGMENT YELLOW 194 has Good heat stability.
PIGMENT YELLOW 194 is Usually recommended for high-grade coating.

PIGMENT YELLOW 194 is a fluorescent dye.
PIGMENT YELLOW 194 can be used as biological dye.

PIGMENT YELLOW 194 is greenish shade yellow pigment powder.
But it is redder than pigment yellow 151.
PIGMENT YELLOW 194 is one of the yellow pigment with best light fastness and weather fastness.

The good flow of PIGMENT YELLOW 194 makes the gloss not affected at high concentration, and is recommended to use in metal decorative paint and automotive paint.
PIGMENT YELLOW 194 is also used in the coloring of soft and rigid PVC.
And the heat stability of PIGMENT YELLOW 194 is HDPE is 210℃/5min.



APPLICATIONS OF PIGMENT YELLOW 194:
Recommended for automotive paints, architectural coatings, coil coatings, industrial paints, powder coatings, printing pastes, water-based inks, solvent inks, UV inks.
PIGMENT YELLOW 194 gives light green yellow, hue angle 95.1 degrees (1/3SD), but it shows red light than CI Pigment Yellow 175, Pigment Yellow 151, and has excellent light fastness, weather resistance and solvent resistance.

Thermal stability, mainly used in coatings.
PIGMENT YELLOW 194 is one of the most light fast and weather resistant yellow varieties.
PIGMENT YELLOW 194 is mainly recommended for metallic decorative paints and automotive coatings (OEM).

Its good rheology does not affect its gloss at high concentrations; PIGMENT YELLOW 194 can also be used for coloring soft and rigid PVC plastic outdoor products; heat resistance in HDPE is 210℃/5min; suitable for printing inks that require high light fastness (printing sample 1/25SD fast 6-7).

Decorative water based paints, decorative solvent based paints, industrial coatings, automotive OEM refinishes, powder coatings, textile printings, offset inks, water based inks, solvent based inks, plastics, rubbers.


BENEFITS OF PIGMENT YELLOW 194:
PIGMENT YELLOW 194 has Very good weather fastness
PIGMENT YELLOW 194 is Easy to disperse in water-based paint systems
PIGMENT YELLOW 194 Improved finishing process with better ecological footprint


CHEMICAL AND PHYSICAL PROPERTIES OF PIGMENT YELLOW 194:

Nom de la propriété Property value
Molecular weight 405,3 g/mole
XLogP3-AA 3.1
Number of hydrogen bond donors 3
Number of hydrogen bond acceptors 8
Number of rotary links 5
Exact mass 405,10487381 g/mole
Monoisotopic mass 405,10487381 g/mole
Topological polar surface 112Ų
Number of heavy atoms 29
Charge formal 0
Complexité 684
Number of isotopic atoms 0
Number of stereocenters of atoms defined 0
Number of atomic stereocenters not defined 1
Number of defined binding stereocenters 0
Number of binding stereocenters not defined 0
Number of covalently bonded units 1
The compound is canonized Oui


Color index Yellow pigment 154
Product Name Corimax Yellow H3G
Product Category Pigment organique
CAS number 82199-12-0
EU number 268-734-6
Chemical family Benzimidazolone
Molecular weight 367.36
Molecular formula C18H17N5O4
PH 7
Densité 1.6
Oil absorption (ml/100g)% 45-55
Lightfastness (coating) 7
Thermal resistance (coating) 180
Résistance à l'eau 5
Résistance à l'huile 5
Résistance aux acides 5
Resistance to alkalis 5
Product Name YELLOW PIGMENT 154
Synonymes CIPIGMENT YELLOW 194; CIPY154; PY154; PY154
THIS 11781
CAS No. 82199-12-0
EINECS 279-914-9
Molecular weight 367.36
Molecular formula C18H17N5O4
Densité 1.52g/cm3
Couleur Yellow powder
Appearance

Yellow powder

Shade

Greenish

Tinting Strength, %

95-105

Oil Absorption, g/100g

35-45

Heat Resistance, °C

250

Light Fastness

7-8

pH Value

5.0-7.0

Density

1.47

BET Surface Area, m2/g

26

Bleeding Resistance

5

Soap Resistance

5

Acid Resistance

5

Alkali Resistance

5

Alcohol Resistance

5

Ester Resistance

5

Benzene Resistance

5

Ketone Resistance

5

Migration Resistance

5
Fastness properties of PIGMENT YELLOW 194:

Lightfastness 7
Heat resistance (℃) 180
Water resistance 5
Oil resistance 5
Acid resistance 5
Resistance to alkalis 5
Alcohol resistance 5
Density(g/cm3)
1.6

Moisture (%)
≤0.5

Water Soluble Matter
≤1.0

Oil Absorption (ml / 100g)
45-55

Electric conductivity (us/cm)
≤500

Fineness(80mesh)
≤5.0

PH value
6.5-7.5

Density [g/cm3] 1.54
Form of Supply powder
Specific surface [m2/g] 22
Oil absorption [ml/100g] 56
Avg. Size of Primary Particles [nm] 275
pH value 7.2
Conductivity [mS/cm] 0.09



SAFETY INFORMATION ABOUT PIGMENT YELLOW 194:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



PIGMENT YELLOW 65

Pigment Yellow 65 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 65 is a monoazo-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 65 is C18H18N4O6, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 6528-34-3
EC Number: 229-419-9

Synonyms: Monoazo Yellow 65, Permanent Yellow RN, CI Pigment Yellow 65, Fast Yellow RN, Hansa Yellow 65, Permanent Yellow 65, Benzidine Yellow 65, Hansa Yellow RN, Irgazin Yellow RN, Hostaperm Yellow RN, Fast Yellow 65, Benzidine Yellow R, Hansa Yellow R, Diarylide Yellow RN, CI 21160, Fast Light Yellow 65, Permanent Yellow R, Hansa Brilliant Yellow 65GX, Fast Yellow R, Hansa Yellow GX, Hostaperm Yellow 65, Permanent Yellow 65R, Irgazin Yellow 65R, Benzidine Yellow GX, Hostaperm Yellow R, Fast Yellow GX, Permanent Yellow GX, Benzidine Yellow R, Diarylide Yellow R, Permanent Yellow 65GX, Fast Yellow RN, Permanent Yellow R, Fast Yellow R, Hansa Yellow GX, Benzidine Yellow GX, Hostaperm Yellow GX, Permanent Yellow 65GX, CI Pigment Yellow RN, Irgazin Yellow R, Fast Yellow GX, Hansa Yellow R, Permanent Yellow GX, CI Pigment Yellow R



APPLICATIONS


Pigment Yellow 65 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 65 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 65 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 65 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 65 is used in automotive coatings for its excellent durability.
Pigment Yellow 65 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 65 is used in water-based paints for its stability and brightness.
Pigment Yellow 65 is a key component in solvent-based paints and coatings.
Pigment Yellow 65 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 65 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 65 is used in the manufacturing of synthetic fibers.
Pigment Yellow 65 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 65 is used in the creation of artist paints and materials.
Pigment Yellow 65 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 65 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 65 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 65 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 65 is essential in the creation of high-quality printing inks.

Pigment Yellow 65 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 65 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 65 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 65 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 65 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 65 is a key ingredient in the production of plastic colorants.

Pigment Yellow 65 is employed in the textile industry to dye fabrics.
Pigment Yellow 65 is used in the rubber industry for coloring rubber products.
Pigment Yellow 65 is essential in the production of artist materials.

Pigment Yellow 65 is a vital component in water-based and solvent-based systems.
Pigment Yellow 65 is applied in the creation of high-performance industrial products.
Pigment Yellow 65 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 65 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 65 is found in the creation of specialty inks for various applications.
Pigment Yellow 65 is used in the production of ceramic and glass products.

Pigment Yellow 65 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 65 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 65 is essential in the production of coatings for wood surfaces.

Pigment Yellow 65 is used in the formulation of high-performance inks.
Pigment Yellow 65 is applied in the creation of coatings for automotive applications.
Pigment Yellow 65 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 65 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 65 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 65 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 65 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 65 is used in the creation of specialty inks for digital printing.
Pigment Yellow 65 is essential in the production of high-performance industrial products.

Pigment Yellow 65 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 65 is used in the creation of water-based and solvent-based products.
Pigment Yellow 65 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 65 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 65 is a monoazo-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 65 is a versatile organic compound with the chemical formula C18H18N4O6.
Pigment Yellow 65 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 65 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 65 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 65 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 65 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 65's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 65 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 65 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 65's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 65 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 65 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C18H18N4O6
Common Name: Pigment Yellow 65
Molecular Structure: C18H18N4O6
Molecular Weight: 370.37 g/mol
Appearance: Bright yellow powder
Density: 1.4 g/cm³
Melting Point: 330°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 65 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 65.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 65 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 65 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 65 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 65 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.

PIGMENT YELLOW 73

Pigment Yellow 73 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 73 is a monoazo-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 73 is C18H18N4O6, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 13515-40-7
EC Number: 236-912-2

Synonyms: Azo Yellow 73, Permanent Yellow HR, CI Pigment Yellow 73, Fast Yellow HR, Benzidine Yellow 73, Hansa Yellow 73, Permanent Yellow 73, Hansa Brilliant Yellow HR, CI 21105, Fast Light Yellow 73, Permanent Yellow 5GX, Benzidine Yellow HR, Hansa Yellow 5GX, Irgazin Yellow 5GX, Hostaperm Yellow 5GX, Fast Yellow HR, Benzidine Yellow GX, Hansa Yellow HR, Diarylide Yellow 5GX, Permanent Yellow HR, Fast Yellow GX, Hansa Yellow 5GX, Hostaperm Yellow HR, Irgazin Yellow 73, Hostaperm Yellow 73, Diarylide Yellow HR, CI Pigment Yellow HR, Permanent Yellow 73GX, Fast Yellow 73, Benzidine Yellow 5GX, CI Pigment Yellow 5GX, Irgazin Yellow HR, Fast Yellow GX, Hansa Yellow GX, Hostaperm Yellow GX, Permanent Yellow 5GX, CI Pigment Yellow 5G



APPLICATIONS


Pigment Yellow 73 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 73 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 73 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 73 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 73 is used in automotive coatings for its excellent durability.
Pigment Yellow 73 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 73 is used in water-based paints for its stability and brightness.
Pigment Yellow 73 is a key component in solvent-based paints and coatings.
Pigment Yellow 73 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 73 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 73 is used in the manufacturing of synthetic fibers.
Pigment Yellow 73 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 73 is used in the creation of artist paints and materials.
Pigment Yellow 73 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 73 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 73 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 73 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 73 is essential in the creation of high-quality printing inks.

Pigment Yellow 73 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 73 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 73 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 73 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 73 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 73 is a key ingredient in the production of plastic colorants.

Pigment Yellow 73 is employed in the textile industry to dye fabrics.
Pigment Yellow 73 is used in the rubber industry for coloring rubber products.
Pigment Yellow 73 is essential in the production of artist materials.

Pigment Yellow 73 is a vital component in water-based and solvent-based systems.
Pigment Yellow 73 is applied in the creation of high-performance industrial products.
Pigment Yellow 73 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 73 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 73 is found in the creation of specialty inks for various applications.
Pigment Yellow 73 is used in the production of ceramic and glass products.

Pigment Yellow 73 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 73 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 73 is essential in the production of coatings for wood surfaces.

Pigment Yellow 73 is used in the formulation of high-performance inks.
Pigment Yellow 73 is applied in the creation of coatings for automotive applications.
Pigment Yellow 73 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 73 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 73 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 73 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 73 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 73 is used in the creation of specialty inks for digital printing.
Pigment Yellow 73 is essential in the production of high-performance industrial products.

Pigment Yellow 73 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 73 is used in the creation of water-based and solvent-based products.
Pigment Yellow 73 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 73 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 73 is a monoazo-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 73 is a versatile organic compound with the chemical formula C18H18N4O6.
Pigment Yellow 73 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 73 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 73 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 73 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 73 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 73's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 73 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 73 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 73's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 73 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 73 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C18H18N4O6
Common Name: Pigment Yellow 73
Molecular Structure: C18H18N4O6
Molecular Weight: 370.37 g/mol
Appearance: Bright yellow powder
Density: 1.4 g/cm³
Melting Point: 330°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 73 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 73.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 73 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.



Storage:

Temperature:
Store Pigment Yellow 73 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 73 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 73 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.

PIGMENT YELLOW 74

Pigment Yellow 74 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 74 is a monoazo-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 74 is C18H18N4O6, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 6358-31-2
EC Number: 228-787-8

Synonyms: Azo Yellow 74, Permanent Yellow GR, CI Pigment Yellow 74, Fast Yellow GR, Benzidine Yellow 74, Hansa Yellow 74, Permanent Yellow 74, Hansa Brilliant Yellow GR, CI 21095, Fast Light Yellow 74, Permanent Yellow 5GX, Benzidine Yellow GR, Hansa Yellow GR, Irgazin Yellow GR, Hostaperm Yellow GR, Fast Yellow GR, Benzidine Yellow GX, Hansa Yellow GR, Diarylide Yellow GR, Permanent Yellow GR, Fast Yellow GX, Hansa Yellow 5GX, Hostaperm Yellow 74, Irgazin Yellow 74, Hostaperm Yellow 74, Diarylide Yellow GR, CI Pigment Yellow GR, Permanent Yellow 74GX, Fast Yellow 74, Benzidine Yellow 5GX, CI Pigment Yellow 5GX, Irgazin Yellow GR, Fast Yellow GX, Hansa Yellow GX, Hostaperm Yellow GX, Permanent Yellow 5GX, CI Pigment Yellow 5G



APPLICATIONS


Pigment Yellow 74 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 74 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 74 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 74 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 74 is used in automotive coatings for its excellent durability.
Pigment Yellow 74 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 74 is used in water-based paints for its stability and brightness.
Pigment Yellow 74 is a key component in solvent-based paints and coatings.
Pigment Yellow 74 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 74 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 74 is used in the manufacturing of synthetic fibers.
Pigment Yellow 74 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 74 is used in the creation of artist paints and materials.
Pigment Yellow 74 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 74 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 74 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 74 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 74 is essential in the creation of high-quality printing inks.

Pigment Yellow 74 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 74 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 74 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 74 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 74 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 74 is a key ingredient in the production of plastic colorants.

Pigment Yellow 74 is employed in the textile industry to dye fabrics.
Pigment Yellow 74 is used in the rubber industry for coloring rubber products.
Pigment Yellow 74 is essential in the production of artist materials.

Pigment Yellow 74 is a vital component in water-based and solvent-based systems.
Pigment Yellow 74 is applied in the creation of high-performance industrial products.
Pigment Yellow 74 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 74 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 74 is found in the creation of specialty inks for various applications.
Pigment Yellow 74 is used in the production of ceramic and glass products.

Pigment Yellow 74 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 74 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 74 is essential in the production of coatings for wood surfaces.

Pigment Yellow 74 is used in the formulation of high-performance inks.
Pigment Yellow 74 is applied in the creation of coatings for automotive applications.
Pigment Yellow 74 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 74 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 74 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 74 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 74 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 74 is used in the creation of specialty inks for digital printing.
Pigment Yellow 74 is essential in the production of high-performance industrial products.

Pigment Yellow 74 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 74 is used in the creation of water-based and solvent-based products.
Pigment Yellow 74 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 74 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 74 is a monoazo-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 74 is a versatile organic compound with the chemical formula C18H18N4O6.
Pigment Yellow 74 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 74 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 74 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 74 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 74 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 74's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 74 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 74 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 74's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 74 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 74 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C18H18N4O6
Common Name: Pigment Yellow 74
Molecular Structure: C18H18N4O6
Molecular Weight: 370.37 g/mol
Appearance: Bright yellow powder
Density: 1.4 g/cm³
Melting Point: 330°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 74 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 74.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 74 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 74 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 74 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 74 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.



PIGMENT YELLOW 74
Pigment Yellow 74 is a greenish shade yellow pigment.
Pigment Yellow 74 has high color strength and exhibits good light and weather fastness.
Pigment Yellow 74 is insoluble in water.


CAS Number: 6358-31-2
EC Number: 228-768-4
MDL Number: MFCD00070296


Pigment Yellow 74 is bright yellow powder.
Pigment Yellow 74 is considerable change and tendency to sublime when heated to melting point.
Pigment Yellow 74 is an organic pigment.
Pigment Yellow 74 is a mono azo pigment powder, with greenish yellow color, and it has a redder tint than pigment yellow 12.


Pigment Yellow 74 offers good color strength, and good dispersion and lower viscosity.
Pigment Yellow 74's greenish yellow shades are somewhere between those of P.Y.3 and P.Y.1.
Pigment Yellow 74 is considerably stronger than and superior to all comparable monoazo yellow pigments.


Pigment Yellow 74 is a water dispersed pigment, exceptionally lightfast, yields an intense lemon-yellow, and is formulated specifically for the coloring of paper pulp.
Pigment Yellow 74 is bright yellow powder.
Pigment Yellow 74 is considerable change and tendency to sublime when heated to melting point.


Pigment Yellow 74 is mono-azo yellow organic pigment.
Pigment Yellow 74 is an opaque and green shade yellow monoazo pigment with very good glycol stability suitable for deco paints, deco colorants, high tinting strength and a very good stability to recrystalization.
Pigment Yellow 74 is a group of green to reddish yellow, synthetic organic monoazo pigments that are produced with acetoacetanilide derivatives as the coupling component.


Pigment Yellow 74 has a good light fastness and weather stability.
Pigment Yellow 74 offers excellent value for architectural coatings with an ideal balance of light fastness, opacity, versatility and strength.
Pigment Yellow 74 is a greenish yellow pigment for inks and coatings.
Pigment Yellow 74 offers better transparency, which makes it recommended for inks.


Pigment Yellow 74 can be used as a replacement products for chrome yellow.
Compared with the fine particle size variety, the non-transparent display is more red light, more light resistant, and the freshness is slightly lower, especially suitable for the coating industrial air self-drying paint, which can increase the concentration and further improve the hiding power without changing the rheological property, and can be used.


There are 126 types of Pigment Yellow 74.
Pigment Yellow 74 is used for ink and paint coloring important varieties, green light yellow (between is C.I. Between pigment yellow 1 and pigment yellow 3), the coloring intensity is higher than that of the general monoazo pigment; More than C.I. Pigment Yellow 12 slightly red light, 1/3SD pigment yellow 12 need 4.5%, and pigment yellow 74 need 4.2%; There are different particle size varieties (specific surface area of 10-70m2/g, the specific surface area of Hansha yellow 5GX02 was 16 m2/g, and the large particle size dosage form (10-20 m2/g) showed high hiding power.


Pigment Yellow 74 is a high hiding pigment power, with very good resistance to light and high Color Strength, Having reddish shade.
Pigment Yellow 74 is an important species to replace inorganic pigment chrome yellow.
Pigment Yellow 74 is an aqueous binder-free pigment preparation manufactured without using alkyl phenol ethoxylated (APEO) additives.
Pigment Yellow 74 preparation is compatible with water-based low VOC and VOC-free decorative coatings.


Pigment Yellow 74 has greenish yellow shade.
Pigment Yellow 74 is a bright yellow with high opaque and very good resistance.
Pigment Yellow 74 is a bright yellow powder.
Pigment Yellow 74 is considerable change and tendency to sublime when heated to melting point.


Pigment Yellow 74 one of the important monoazo pigments type.
Pigment Yellow 74 is bright and greenish shade yellow (between CI Pigment Yellow 3 and Pigment Yellow 1).
If in the consideration of eco-friendly, Pigment Yellow 74 is top choice if customers want to use yellow pigments without chlorine atoms.
The commercial value of Pigment Yellow 74 is very high.


For the light fastness, Pigment Yellow 74 is 2-3 levels better than bisazo yellow pigments.
Pigment Yellow 74 is a bright yellow powder.
Pigment Yellow 74 is an opaque, greenish yellow monoazo pigment.
Pigment Yellow 74 offers excellent rheological properties and moderate fastness properties.
Pigment Yellow 74 has good recrystallization stability.



USES and APPLICATIONS of PIGMENT YELLOW 74:
Pigment Yellow 74 organic pigments can be used in transparent or opaque versions; they are recommended pigments for use in water-based decorative paints, water-based inks, solvent-based inks, paste inks and solvent-based air-drying paints.
Pigment Yellow 74 exhibits a very good rheology profile and is also suitable for the production of pigment concentrates with universal properties in decorative paint applications.


Pigment Yellow 74 is an important pigment for the coloring of inks and coatings, greening shade (between CI Pigment Yellow 1 and Pigment Yellow 3), the coloring strength is higher than general monoazo pigments; slightly reddish than CI Pigment Yellow 12, 1/ Pigment Yellow 12 requires 4.5% under 3SD, and Pigment Yellow 74 requires 4.2%; there are varieties with different particle sizes (specific surface area is 10-70m2/g, of which Hansa Yellow 5GX02 specific surface area is 16m2/g), large particle size dosage form (10-20m2/g) shows high hiding power.


Main application of Pigment Yellow 74: Paint,Water based ink, Textile printing, Plastic.
Compared with fine-grained varieties, non-transparent displays are more reddish, more light-resistant, and have a slightly lower vividness.
Pigment Yellow 74 is especially suitable for coating industrial air-drying paints.
Pigment Yellow 74 can increase the concentration to further improve the hiding power without changing the rheology.


Pigment Yellow 74 is good use in a wide variety of applications including plastics, paints, printing inks.
Pigment Yellow 74 is especially good for coating industry air-drying paints.
Pigment Yellow 74 comes in high quality, colorfast and very washable.
Pigment Yellow 74 is recommended for coating and interior paint.


Pigment Yellow 74's an important grade in coating industry.,
The color shade is kind of greenish yellow between PY1 and PY3 and color strength is higher than normal Azo pigment.
Pigment Yellow 74 is used in emulsion paints, toy enamels, paints, printing inks, and pigment pastes
Pigment Yellow 74 is an Azo Monoarylide organic pigment suitable for applications including paints, coatings and inks.


Pigment Yellow 74, a commercial pigment of considerable significance, is used primarily in the printing ink and paint industries.
Pigment Yellow 74 is medium yellow opaque pigment with excellent lightfastness, weather fastness and rheological properties meant for coating application.
Pigment Yellow 74 is suitable for alkyd resins, industrial paints, powder coating and water based flexo inks.


Pigment Yellow 74 is used Paints – Air drying, Stoving, Waterbase, Powder Coating.
Pigment Yellow 74 is used for paints , plastics and printing inks .
Pigment Yellow 74 is used in water based as well as in solvent based systems.
Recommend: Water based ink, water based paints and textile printing.


Pigment Yellow 74 is suggested for water based decorative paint and NC inks, offset inks.
Pigment Yellow 74 is used Water-base decorative paint, solvent-base decorative paint, industrial paint, coil coating.
Recommend uses of Pigment Yellow 74: Water based ink, water based paints and textile printing.
Pigment Yellow 74 is suggested for water based decorative paint and NC inks, offset inks.


Pigment Yellow 74 is used water-base decorative paint, solvent-base decorative paint, industrial paint, coil coating.
Varieties with different particle sizes are used primarily in the printing ink industry.
Pigment Yellow 74 is formulated so that it is compatible in a wide array of industrial applications.
Pigment Yellow 74 is a diazonium salt and reactive chemical that has been shown to be useful for the detection of metals.


Pigment Yellow 74 reacts with metal ions to form hydroxylated, carbonylated, and aliphatic hydrocarbon products.
Pigment Yellow 74 also reacts with hydroxyl groups on a surface of a metal to form an electron-dense particle.
Pigment Yellow 74 is stable in the dark but will react with light or heat to produce a yellow color.
Pigment Yellow 74 is manufactured by 2-Methoxy-4-nitrobenzenamine diazotization, and N-(2-methoxyphenyl)-3-oxobutanamide coupling.


Pigment Yellow 74 has good light fastness.
Pigment Yellow 74 has been used as a marker for detecting infectious diseases and as an indicator of low-intensity light.
Pigment Yellow 74 is used Coating Pigment, Cosmetic Pigment, Ink Pigments, Plastic Pigment, Rubber Pigment, Leather Pigments, Ceramic Pigments.
Pigment Yellow 74 is recommended for use in exterior trade sales coatings, colorant systems and air-dry industrial coatings.


Other uses of Pigment Yellow 74 include various printing ink applications where improved lightfastness is required over diarylide yellow types.
Pigment Yellow 74's main use is industrial paint, water based decorative paint.
Suggested for water-based ink.
Pigment Yellow 74 is widely used in Paints, Plastics, Printing inks, textile printing.


Pigment Yellow 74 is also used in special applications such as stationery and seed coloration.
So, Pigment Yellow 74 is often applied in applications needs high light fastness, such as packaging printing inks, and outdoor latex paint.
Pigment Yellow 74 also has high tinting strength , which is almost twice of other usual monoazo pigments).
Pigment Yellow 74 is applied in NC gravure ink,water-based ink,traffice paint and latex paint.


Pigment Yellow 74 is recommended for use in exterior trade sales coatings, colorant systems and air-dry industrial coatings.
Other uses of Pigment Yellow 74 include various printing ink applications where improved lightfastness is required over diarylide yellow types.
Pigment Yellow 74 is recommended pigments for use in water-based decorative paints, water-based inks, solvent-based inks, paste inks and solvent-based air-drying paints.


-Recommended Application of Pigment Yellow 74:
*coatings: architectural coatings, coil coatings, industrial paints,
*Printing inks: offset inks, water-based inks, solvent inks, UV inks, printing pastes


-Applications of Pigment Yellow 74:
*Coatings
*Decorative Paints
*Solvent Based
*Water Based
*Industrial Coatings
*General Industrial Paint


-Main Fields of Application of Pigment Yellow 74:
*Low and no VOC Decorative Paints
*Low and no VOC Wood Coatings
*Waterborne Emulsion Paints
*Aqueous polymer dispersions


-Further possible Fields of Application of Pigment Yellow 74:
*Water-based Floor Coatings
*Latex coloration
*Water resistant Inks and many more.



KEY FEATURES OF PIGMENT YELLOW 74:
*Suitable for high loading pigment concentrates
*Good weather fastness within PY 74 class
*Ideal for lead chrome replacement



BENEFITS OF PIGMENT YELLOW 74:
*Binder-free aqueous pigment preparation for water-based decorative paints
*Manufactured without using alkyl phenol ethoxylated (APEO) additives
*Suitable for manual and automatic dispensing equipment
*Narrow tolerances of shade and color strength for exact color reproduction
*Miscible in all proportions with each other pigment preparation of the Colanyl 500 range



FEATURES OF PIGMENT YELLOW 74:
Pigment Yellow 74 is a bright yellow pigment with high business value.
Opaque, Semi opaque and transparent types are available.
Pigment Yellow 74 has the strongest coloring strength among all monoazo pigments.
Pigment Yellow 74's resistance in acid and alkali condition is good.

The light fastness of Pigment Yellow 74 is much higher than azo pigmnents, so it is applied in fields that requires high light fastness, such as package ink or indoor out door decorative paint.
Pigment Yellow 74 is a universal semi-transparent green shade monoazo pigment yellow 74.
Pigment Yellow 74 is considerably stronger than and superior to all comparable monoazo yellow pigments.

Pigment Yellow 74 is a high hiding pigment power, with very good resistance to light, weather fastness and high color strength, having reddish shade.
Pigment Yellow 74 is an important species to replace inorganic pigment chrome yellow.
Pigment Yellow 74 exhibits a very good rheology profile and is also suitable for the production of pigment concentrates with universal properties in decorative paint applications.



PROPERTIES AND APPLICATIONS OF PIGMENT YELLOW 74:
Pigment yellow 74 is an important commercial pigment, which is mainly used in printing ink and coating industry.
Pigment Yellow 74's color paste is between pigment yellow 1 and pigment yellow 3, and its coloring power is higher than that of any other mono even nitrogen pigment yellow.
Pigment yellow 74 is acid, alkali and saponification resistant, but it is easy to frost, which hinders its application in baking enamel.
The light fastness of pigment yellow 74 is 2-3 grades higher than that of Bisazo yellow pigment with similar colouring power, so it can meet the requirements of high light fastness, such as printing ink for packaging.
At the same time, pigment yellow 74 is also widely used in latex paint as interior wall and dark exterior wall coloring.



PHYSICAL and CHEMICAL PROPERTIES of PIGMENT YELLOW 74:
Melting point: 293°C
Boiling point: 577.2±50.0 °C(Predicted)
Density: 1.436 g/cm3
pka: 0.78±0.59(Predicted)
Water Solubility: Light Fastness: 5-6
Heat Resistance(℃): 140
Water Resistance: 5
Oil Resistance: 4-5
Acid Resistance: 5
Alkali Resistance: 5
Alcohol Resistance: 4-5
Color: bright yellow powder
pigment (CI name): pigment yellow 74
dispersion type: resinated
percent pigment: 35%
percent solids: 48%
thermal stability: 140° C
light stability: masstone: 7, tint: 6

Physical state and appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 386.22 g/mole
Color: Yellow.
pH (1% soln/water): Not applicable.
Boiling Point: Not available.
Melting Point: >250°C (482°F)
Critical Temperature: Not available.
Specific Gravity: 1.4 (Water = 1)
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Ionicity (in Water): Not available.
Solubility: Insoluble in cold water.

Relative density: 1.28-1.51
Bulk density/(lb/gal): 10.6-12.5
Melting point/℃: 275-293
Average particle size/ μ m:0.18
Particle shape: rod or needle
Specific surface area/(m2/g): 14
PH value/(10% slurry): 5.5-7.6
Oil absorption/(g/100g): 27-45
Covering power: opaque/semi-transparent/transparent
Density: 1.33 g/cm3
Boiling Point: 577.2ºCat 760 mmHg
Melting Point: 293ºC
Molecular Formula: C18H18N4O6
Molecular Weight: 386.35900
Flash Point: 302.9ºC
Exact Mass: 386.12300
PSA: 135.17000
LogP: 3.88820
Index of Refraction: 1.6
Water Solubility:
Molecular Formula: C18H18N4O6
Molar Mass: 386.36
Density: 1.436 g/cm3
Melting Point: 293°C
Boling Point: 577.2±50.0 °C(Predicted)
Flash Point: 302.9°C
Water Solubility: Vapor Presure: 2.55E-13mmHg at 25°C
pKa: 0.78±0.59(Predicted)
Refractive Index: 1.6
hue or color: bright yellow
relative density: 1.28-1.51
Bulk density/(lb/gal):10.6-12.5
melting point/℃:275-293
average particle size/μm:0.18
particle shape: Rod or needle

specific surface area/(m2/g):14
pH value/(10% slurry):5.5-7.6
oil absorption/(g/100g):27-45
hiding power: translucent/transparent
Molecular weight: 386.3587
C.I. Index: Pigment Yellow 74
CAS No.: 6358-31-2
Hue or color light: bright yellow or green yellow
Relative density: 1.28-1.51
Bulk density / (LB / gal): 10.6-12.5
Melting point / ℃: 275-293
Particle shape: stick or needle
Specific surface area / (m2 / g): 14
Oil absorption / (g / 100g): 27-45
Hiding power: translucent / transparent



FIRST AID MEASURES of PIGMENT YELLOW 74:
-Eye Contact:
Check for and remove any contact lenses.
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes.
-Skin Contact:
Wash with soap and water.
*Serious Skin Contact:
Not available.
-Inhalation:
If inhaled, remove to fresh air.
Get medical attention.
-Serious Inhalation:
Not available.
-Serious Ingestion:
Not available.



ACCIDENTAL RELEASE MEASURES of PIGMENT YELLOW 74:
*Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container.
*Large Spill:
Use a shovel to put the material into a convenient waste disposal container.
Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.



FIRE FIGHTING MEASURES of PIGMENT YELLOW 74:
-Auto-Ignition Temperature:
Not available.
-Flash Points:
Not available.
-Flammable Limits:
Not available.
-Special Remarks on Explosion:
Not available.



EXPOSURE CONTROLS/PERSONAL PROTECTION of PIGMENT YELLOW 74:
-Personal Protection:
Safety glasses.
Lab coat.
Dust respirator.
-Exposure Limits:
Not available.



HANDLING and STORAGE of PIGMENT YELLOW 74:
*Precautions:
Ground all equipment containing material.
Do not ingest.
*Storage:
Keep container tightly closed.
Keep container in a cool, well-ventilated area.



STABILITY and REACTIVITY of PIGMENT YELLOW 74:
*Stability:The product is stable.
*Conditions of Instability: Excess heat
*Incompatibility with various substances: Not available.
*Corrosivity: Not available.
*Dalamar Yellow Special Remarks on: Not available.
*Reactivity Special Remarks on: Not available.
*Corrosivity Polymerization: Will not occur.



SYNONYMS:
ponolithyellowy
lunayellow
C.I. 11741
NCI-C-61132
DALAMAR YELLOW
PY74 TRANSPARENT
PIGMENT YELLOW 74
Dalamar(R) Yellow
Pigment Yellow 5GX
permanent yellow gx
2-((2-Methoxy-4-nitrophenyl)azo)-o-acetoacetanisidide
Butanamide, 2-((2-methoxy-4-nitrophenyl)azo)-N-(2-methoxyphenyl)-3-oxo-
CI 11741
Dalamar Yellow
Hansa Brilliant Yellow 5GX
Luna Yellow
Permanent Yellow, lead free
Pigment Yellow 74
Ponolith Yellow Y
C.I. Pigment Yellow 74
6358-31-2
Dalamar Yellow
Pigment Yellow 74
Butanamide, 2-((2-methoxy-4-nitrophenyl)azo)-N-(2-methoxyphenyl)-3-oxo-
C.I. 11741
Luna Yellow
2-[(E)-(2-Methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
Butanamide, 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-
Ponolith Yellow Y
Butanamide,2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-
Hansa Brilliant Yellow 5GX
Permanent Yellow, lead free
CCRIS 3192
HSDB 5181
EINECS 228-768-4
CI 11741
PigmentYellow74
2-((2-Methoxy-4-nitrophenyl)azo)-o-acetoacetanisidide
PY74 dye
Color Index 11741
2-((2-Methoxy-4-nitrophenyl)azo)-N-(2-methoxyphenyl)-3-oxobutyramide
EC 228-768-4
Pigment Yellow 74, tech.
SCHEMBL270063
DTXSID7025920
SCHEMBL12912517
MFCD00070296
2-[(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
CI11741
CI-11741
C.I.11741
FT-0726755
W-110107
Q27269580
2-((2-methoxy-4-nitrophenyl)azo)-n-(2-methoxyphenyl)-3-oxobutanamide
2-[(2-Methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-butanamide
2-[(E)-(2-Methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
Butanamide, 2-(2-(2-methoxy-4-nitrophenyl)diazenyl)-N-(2-methoxyphenyl)-3-oxo-
11741
C.I. 11741
lunayellow
DALAMAR YELLOW
dalamar yellow
ponolithyellowy
Pigment Yellow 74
c.i.pigmentyellow74
C.I. Pigment Yellow 74
permanentyellow,leadfree
2-[(2-Methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide
2-(2-methoxy-4-nitro-phenyl)azo-N-(2-methoxyphenyl)-3-oxo-butanamide
2-[(E)-(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
11741
C.I. Pigment Yellow 74
Pigment Yellow 74
2-[(E)-(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
2-(2-methoxy-4-nitro-phenyl)azo-N-(2-methoxyphenyl)-3-oxo-butanamide
C.I. 11741
DALAMAR YELLOW
2-[(2-Methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide
permanent yellow gx
PIGMENT YELLOW 74
2-((2-methoxy-4-nitrophenyl)azo)-n-(2-methoxyphenyl)-3-oxo-butanamid
2-[(2-methoxy-4-nitrophenyl)azo]-n-(2-methoxyphenyl)

PIGMENT YELLOW 83
Pigment Yellow 83 is a reddish shade yellow bis-azo pigments.
Pigment Yellow 83 has bright color, good heat resistance, satisfactory light fastness, and good solvent resistance.
In alkyd paint, the light fastness of Pigment Yellow 83 can reach 6-7 and the weather resistance is excellent .


CAS Number: 5567-15-7
EC Number: 226-939-8
MDL Number: MFCD00071958
Chemical formula: C36H32Cl4N6O8


In the baking paint, Pigment Yellow 83 also has better heat-resistance than other benzidine yellow pigments.
Pigment Yellow 83 is designed for PVC coloring.
Pigment Yellow 83 is an organic compound that is classified as a diarylide pigment.
Pigment Yellow 83 is used as a yellow colourant.


Pigment Yellow 83 is a reddish yellow pigment with good resistance to both light and heat.
Pigment Yellow 83 is recommend for PVC, PU, RUB, PE, PP, PP fiber.
Pigment Yellow 83 has good fastness and high color strength with low price.
Pigment Yellow 83 is kind of very reddish grade in the pigment yellow.Its properties is very suit for the pigment paste.


Pigment Yellow 83 is an organic compound that is classified as a diarylide pigment.
Pigment Yellow 83 is synthesized from three components. Treatment of 2,5-dimethoxy-4-chloroaniline with diketene gives an acetoacetylated aniline.
Pigment Yellow 83 is then coupled to the bisdiazonium salt obtained from 3,3'-dichlorobenzidine


Pigment Yellow 83 pigments offer better solvent and migration resistance than Monoazo Yellow pigments making them a good pigment for inks, plastics and coatings applications.
Pigment Yellow 83 is also called diarylide yellow HR, it is equivalent to Novoperm Yellow HR 02 , PV Fast Yellow HG.
Pigment Yellow 83 have the good colorant in the HDPE.


Pigment Yellow 83's advantage is golden yellow and high color strength.
Pigment Yellow 83 has the good light fastness ,heat resistance and migration hesistance,more reddish than yellow 13.
Pigment Yellow 83 is yellow powder.
Pigment Yellow 83's heat resistance is stable at 200 ℃.


Other properties of Pigment Yellow 83, such as light resistance, solvent resistance, acid resistance and alkali resistance are excellent.
Pigmnet Yellow 83 has a specific surface area of ​​69m2/g, and has excellent light resistance, heat resistance, solvent resistance and migration resistance.
Pigment Yellow 83 gives a stronger red light yellow than pigment yellow 13 (similar to pigment yellow 10, and its strength is twice as high).


Pigment Yellow 83 is an organic compound that is classified as a diarylide pigment.
Pigment Yellow 83 is synthesized from three components. Treatment of 2,5-dimethoxy-4-chloroaniline with diketene gives an acetoacetylated aniline.
Pigment Yellow 83 is then coupled to the bisdiazonium salt obtained from 3.3'-dichlorobenzidine.


Pigment Yellow 83 is an organic compound that belongs to the group of glycol esters.
Pigment Yellow 83 has been shown to contain nitrogen atoms in its chemical structure and contains a reactive hydrogen atom (H) on the hydroxyl group.
This reactive form of Pigment Yellow 83 may have carcinogenic potential due to its ability to cause DNA damage.


Pigment Yellow 83 also contains a hydroxyl group (-OH) attached to an amine (-NH2).
The presence of this amine makes this compound chemically reactive and capable of forming bonds with other molecules or particles.
Pigment Yellow 83 types is an extremely opaque form.
Pigment Yellow 83 provides finishes with good flow properties and makes it easy to increase the pigment concentration, which in turn improves the hiding power.


Pigment Yellow 83 is considerably more weatherfast than its more transparent counterparts, which makes its full shades useful colorants for original automobile finishes (O.E.M.).
Pigment Yellow 83 is found in a variety of high grade industrial finishes.
Pigment Yellow 83 is a transparent red shade yellow pigment with very high color strength.


Pigment Yellow 83’s processing temperature less than 180℃. Comparable with Clariant HR02, HR, HR70.
Pigment Yellow 83 is redder than pigment yellow 13, The pigment concentration required for 1/3 SD HDPE coloration (1% TiO 2 ) is only 0.08%.
Pigment Yellow 83 shows good to very good resistance to most solvents, no migration in plasticized PVC even at low pigment levels.
Pigment Yellow 83 is yellow organic pigment.


Pigment Yellow 83 possesses excellent physical and chemical properties.
Pigment Yellow 83 is skin friendly.
Pigment Yellow 83 offers color fastness and longer shelf life.
Pigment Yellow 83 is an organic compound that is classified as a diarylide pigment.


Pigment Yellow 83 is synthesized from three components. Treatment of 2,5-dimethoxy-4-chloroaniline with diketene gives an acetoacetylated aniline.
Pigment Yellow 83 is then coupled to the bisdiazonium salt obtained from 3,3'-dichlorobenzidine.
Pigment Yellow 83 is a semi-transparent yellow pigment with good resistance to both light and solvents.


Pigment Yellow 83 is red yellow powder.
Pigment Yellow 83's heat resistance is stable at 200 ℃.
Other properties of Pigment Yellow 83, such as Sun resistance, solvent resistance, acid resistance, alkali resistance are excellent.


There are 129 types of this product.
Pigment Yellow 83 has a specific surface area of 69 m2/g, has excellent light resistance, heat resistance, solvent resistance and migration resistance, and gives a stronger red light yellow than Pigment Yellow 13 (similar to Pigment Yellow 10, the intensity should be 1 times higher).


Pigment Yellow 83, red yellow powder, specific surface area of 69 m2/g, it has excellent light resistance, heat resistance, solvent resistance and migration resistance, giving a stronger red light yellow than Pigment Yellow 13 (similar to Pigment Yellow 10, the intensity is 1 times higher), suitable for all kinds of printing ink and automotive coatings (OEM), latex paint.
Pigment Yellow 83 is a soft PVC that does not undergo migration and bleeding even at low concentrations, light fastness 8 (1/3SD), 7 (1/25SD); High color strength (1/3SD) in HDPE, pigment concentration of 0.8%.



USES and APPLICATIONS of PIGMENT YELLOW 83:
Pigment Yellow 83 is mainly used for coloring.
Pigment Yellow 83 is stable in plastics without migration and are applied in EVA,PVC, TPR,PP and PE.
Application of Pigment Yellow 83: Offset Ink, Flexo Inc, PVC, Polyolefins, Polystyrene, ABS, Eva/Rubber, PP, Auto-Motive Coating, Industrial Coating, Decorative Coating, Coil Coating, Powder Coating, Textile Printing


Pigment Yellow 83 is mainly used in the coloring of soft PVC materials.
Such as PVC leather.
The main application of Pigment Yellow 83: Water-based ink, Solvent-based ink, Paint, Plastic, Textile printing.
Pigment Yellow 83 is used as a yellow colorant.


Pigment Yellow 83 is suitable for all kinds of printing inks, automotive coatings (OEM), latex paint; widely used in plastic coloring, soft PVC does not migrate and bleed even at low concentrations, light fastness is 8 (1/3SD), Grade 7 (1/25SD); has high coloring strength (1/3SD) in HDPE, and the pigment concentration is 0.8%.


Pigment Yellow 83 can also be used for solvent-based wood coloring, art color, and brown with carbon black.
The quality of Pigment Yellow 83 can meet For fabric printing and dyeing, the dry and wet treatment will not affect the shade.
Pigment Yellow 83 is used as a yellow colorant.
Pigment Yellow 83 is used industrial paint, decorative paint, powder coating, coil coating, textile printing.


Pigment Yellow 83 is used in the chemical, paints-lacquers-varnishes, polymers, and textile processing industries.
Pigment Yellow 83 is used as a coloring agent.
Pigment Yellow 83 is used to formulate/dye pigments, adhesives-sealants, paints-coatings-thinners, inks-toners, textiles, leather, paper-board, metal surface treatment products (including those for galvanizing and electroplating), non-metal surface treatment products, polymers, fertilizers, washing-cleaning products, polishes-waxes, fillers-putties-plasters, and cosmetics-personal care products.


Pigment Yellow 83 is used Printing ink, Plastic, Paint, and coating etc.
Pigment Yellow 83 is Recommended for normal use, medium resistance like PP,PE.
Pigment Yellow 83 can be used for film blowing,extrusion molding,injection,coating etc.


Pigment Yellow 83 is an AADMCA Diarylide Yellow pigment suitable for inks, coating and plastic applications.
Pigment Yellow 83 is a reactive dye that can be used for coloring textiles, plastics, and other materials.
Pigment Yellow 83 also lends itself to paints for automobile refinishes and tractor and implement finishes.
Good overall fastness and considerable tinctorial strength broaden the scope of Pigment Yellow 83 application.


Pigment yellow 83 Application: Semi-transparent, Aqueous inks, Aqueous coating, Plastic.
Pigment Yellow 83 is a semi-transparent very strong, red shade, diarylide pigment yellow 83 offering particularly high tinting strength and excellent overall fastness for all paint systems.
Pigment Yellow 83 is used in industrial coatings and emulsion paints.


Pigment Yellow 83 also is recommended for offset and tin printing inks, as well as for solvent- and water-based packaging gravure and flexographic printing inks.
Pigment Yellow 83 is used Gravure, Flexo, Sheet-fed Offset, Web Offset, Newspaper, UV, Screen.
Pigment Yellow 83 is used as a yellow colorant.


Pigment Yellow 83's main use is industrial paint, decorative paint, coil coating, offset ink, UV ink, water based ink, textile printing and PVC, RUB, EVA,PE.
Pigment Yellow 83 is suggested for PP, PU.
Pigment Yellow 83 is reddish yellow transperent pigment with excellent lightfastness and overall fastness properties meant for coating application.


Pigment Yellow 83 is a water dispersed pigment, exceptionally lightfast, yields an orange-yellow color, and is formulated specifically for the coloring of paper pulp.
Pigment Yellow 83 is suitable for all kinds of printing ink and automotive coatings (OEM), latex paint.
Pigment Yellow 83 is widely used in plastic coloring, soft PVC even at low concentrations does not occur migration and bleeding, light fastness 8 (1/3SD), 7 (1/25SD); High color strength (1/3SD) in HDPE, pigment concentration of 0.8%.


Pigment Yellow 83 can also be used for solvent-based wood coloring, Art color, and carbon black to make Brown.
The quality of Pigment Yellow 83 can meet the fabric printing and dyeing, dry and wet treatment does not affect the color light, to prepare the shape.
Pigment Yellow 83 is widely used in plastic coloring.


Pigment Yellow 83 can also be used for solvent-based wood coloring, Art color, and carbon black to make Brown.
The quality of Pigment Yellow 83 can meet the fabric printing and dyeing, dry and wet treatment does not affect the color, in the form of preparation for viscose fiber polypropylene and other pulp coloring.


-Pigment Yellow 83 is used:
*Rubber: Rubber Coating
*Paint: Decorative Paints/Industrial Paints,
Powder Coating
*Ink: Printing Ink, Water based, Solvent
based, Flexographic inks
*Plastics: Master batches
*Rubber: Rubber Coating



PROPERTIES AND APPLICATIONS OF PIGMENT YELLOW 83:
*red light yellow.
*Red light yellow powder.
*The properties such as light fastness, heat resistance, solvent resistance, acid resistance, alkali resistance are excellent. *Pigment Yellow 83 is mainly used in printing ink, plastic products and paint color.



PROPERTIES OF PIGMENT YELLOW 83:
Pigment Yellow 83 is a red shade diarylide yellow pigment with good allround fastness properties.
*Paint Decorative Paints/Industrial Paints,
*Powder Coating
*Ink Printing Ink, Water based, Solvent based, Flexographic inks
*Plastics Master batches



FEATURES OF PIGMENT YELLOW 83:
*Pigment Yellow 83 is reddish yellow powder.
*Pigment Yellow 83 has excellent migration ability and is not easy to have color penetration.
*Pigment Yellow 83 also has good heat resistance and is stable around 200℃.
*Pigment Yellow 83 is easy to be dispersed, and performance is stable in paint, plastic and ink.
*Pigment Yellow 83 has good solvent resistance,such as in ethanol, and acetate etc, and its performance is good in both acid and alkali condition.
*The light fastness of Pigment Yellow 83 is 6-7 and is excellent among azo pigments.



PRODUCTION METHOD OF PIGMENT YELLOW 83:
reaction equation operating method a diazotization reactor was charged with 16.3 of water, 3,3 '-dichlorobenzidine hydrochloride, 35% hydrochloric acid 16kg, cooling to 0~5 deg C, add 25% sodium nitrite solution 28.4, reaction 30min, decolorizing with activated carbon, destroy excess sodium nitrite, filtration, diazonium salt preparation coupling. 2, 5-dimethoxy-4-chloroacetoacetanilide 29.91G was mixed with 40% of water and 10kg of sodium hydroxide, 50kg of sodium acetate was added, and 85kg of formic acid was added dropwise.
Coupled with the diazonium salt at 5-10 °c, stirring was continued for 30-60 min, the temperature was raised to 90-95 °c and maintained for 30-60min.
Pigment Yellow 83 was filtered and dried.



PREPARATION OF PIGMENT YELLOW 83:
Step 1:
Add 500 parts by weight of deionized water, 70 parts by weight of sodium hydrosulfite, 120 parts by weight of DCB and 180 parts by weight of hydrochloric acid solution, stirring for 4min.

Step 2, add a certain amount of ice to the first reaction vessel 1, after cooling the interior of the first reaction vessel 1 to 2 ° C., 50 parts by weight of an aqueous solution of sodium nitrite is put into the first reaction vessel 1, and stirring is performed again to conduct a diazotization reaction, the diazonium liquid is obtained by filtration (the diazotization is relatively complete, the decomposition of sodium nitrite is less, the diazotization of sodium nitrite is carried out at the same time as the nitrogenation of hydrochloric acid, and the complete yield of the diazotization reaction is high).

Step 3, add 800 parts by weight of deionized water and 300 parts by weight of phenol AS-IRG (phenol AS-IRG also known as 4-chloro-2, 5-dimethoxyacetoacetanilide) to the second reaction vessel 2, after stirring for 3min, a certain amount of liquid alkali is added, and the temperature in the second reactor 2 is adjusted to 10 ° C.

In step 4, 60 parts by weight of glacial acetic acid is added dropwise to the second reactor 2 in the third step, the pH in the second reaction vessel 2 is adjusted to 6, and then the temperature is adjusted to 15 ° C., and the mixture is stirred uniformly to form a coupling solution.

Step 5,
After stirring for 1-1.5h in step 4, the diazo liquid obtained in step 2 is added to the coupling liquid obtained in step 4.
After completion of coupling, the temperature in the second reaction vessel 2 is increased to 80 ℃, and heat preservation 1.5h, after filtration, washing, drying, grinding processing to get pigment yellow 83 pigment crude cake.

Step six, the pigment crude filter cake is added to an organic solvent, mixed and stirred evenly, kept for 6 hours, washed with water until neutral, dried at a temperature of 90 ° C., and pulverized to obtain pigment yellow 83 finished product.
The diazotization reaction time was 1.5h, the coupling reaction was controlled at 40 C under the condition of micro negative pressure, the coupling reaction time was 2h, and the final pH value was 7 after the completion of the coupling reaction.



PHYSICAL and CHEMICAL PROPERTIES of PIGMENT YELLOW 83:
Chemical formula: C36H32Cl4N6O8
Molar mass: 818.49 g·mol−1
Appearance: Yellow solid
Physical Form (at 20°C): Solid
Melting Point: >300°C
Long-Term Storage: Store long-term in a cool, dry place
Note: Sold as technical grade. Not an analytical standard. No purity specification available.
speed of light: 5-6
Heat Resistance (℃): 200
water resistance: 5
Oil Resistance: 5
Acid Resistance : 5
Alkali Resistance: 5
Alcohol Resistance: 4-5
Molecular Weight: 818.49
Molecular Formula: C36H32CI4N6O8
P.H. Value: 6.0-7.0

Densit: 1.7
Oil Absorption(ml/100g)%: 35-45
Light Fastness: 8
Heat Resistance: 210 (°C)
Water Resistance: 5
Oil Resistance: 5
Acid Resistance: 5
Alkali Resistance: 5
Physical state: Solid. Powder.
Colour: Yellow.
Odour: no data available
Melting point/freezing point: no data available
Boiling point or initial boiling point and boiling range: 876.7ºC at 760mmHg
Flammability: no data available
Lower and upper explosion limit/flammability limit: no data available
Flash point: 484ºC

Auto-ignition temperature: 220 °C. Atm. press.:Ca. 1 013 hPa.
Decomposition temperature: no data available
pH: no data available
Kinematic viscosity: no data available
Solubility: In water: 8.1 µg/L. Temperature:23 °C. pH:Ca. 7.
Partition coefficient n-octanol/water:
Pow = 1. Temperature:24 °C.;
log Pow = 0.02. Temperature:24 °C.
Vapour pressure: no data available
Density and/or relative density: 1.5 g/cm³. Temperature:20 °C.
Relative vapour density: no data available
Particle characteristics: no data available
Molecular Formula: C36H32Cl4N6O8
Molar Mass: 818.49
Density: 1.43±0.1 g/cm3(Predicted)
Melting Point: > 300°C (dec.)
Boling Point: 876.7±65.0 °C(Predicted)
Flash Point: 484°C
Vapor Presure: 3.03E-31mmHg at 25°C

Appearance: Solid
Color: Yellow
pKa: 0.76±0.59(Predicted)
Storage Condition: Refrigerator
Stability: Stable.
Refractive Index: 1.628
hue or color: red and yellow
relative density: 1.27-1.50
Bulk density/(lb/gal):10.1-12.5
melting point/℃:380-420
average particle size/μm:0.06-0.13
particle shape: acicular
specific surface area/(m2/g):49(B3R)
pH value/(10% slurry):4.4-6.9
oil absorption/(g/100g):39-98
hiding power: transparent



FIRST AID MEASURES of PIGMENT YELLOW 83:
-Description of necessary first-aid measures:
*If inhaled:
Move the victim into fresh air.
*Following skin contact:
Take off contaminated clothing immediately.
Wash off with soap and plenty of water.
Consult a doctor.
*Following eye contact:
Rinse with pure water for at least 15 minutes.
Consult a doctor.
*Following ingestion:
Rinse mouth with water.
Do not induce vomiting.
-Most important symptoms/effects, acute and delayed:
no data available
-Indication of immediate medical attention and special treatment needed, if necessary:
no data available



ACCIDENTAL RELEASE MEASURES of PIGMENT YELLOW 83:
-Environmental precautions:
Prevent further spillage or leakage if it is safe to do so.
Do not let the chemical enter drains.
Discharge into the environment must be avoided.
-Methods and materials for containment and cleaning up:
Collect and arrange disposal.
Keep the chemical in suitable and closed containers for disposal.



FIRE FIGHTING MEASURES of PIGMENT YELLOW 83:
-Suitable extinguishing media:
Use dry chemical, carbon dioxide or alcohol-resistant foam.
-Specific hazards arising from the chemical:
no data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of PIGMENT YELLOW 83:
-Control parameters:
*Occupational Exposure limit values:
no data available
*Biological limit values:
no data available
-Appropriate engineering controls
Ensure adequate ventilation.
Handle in accordance with good industrial hygiene and safety practice.
-Individual protection measures, such as personal protective equipment (PPE):
*Eye/face protection:
Wear tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Thermal hazards:
no data available



HANDLING and STORAGE of PIGMENT YELLOW 83:
-Precautions for safe handling:
Handling in a well ventilated place.
-Conditions for safe storage, including any incompatibilities:
Store the container tightly closed in a dry, cool and well-ventilated place.
Store apart from foodstuff containers or incompatible materials.



STABILITY and REACTIVITY of PIGMENT YELLOW 83:
-Reactivity:
no data available
-Chemical stability:
no data available
-Possibility of hazardous reactions:
no data available
-Conditions to avoid:
no data available
-Incompatible materials:
no data available
-Hazardous decomposition products:
no data available



SYNONYMS:
Enceprint Yellow 1780, Homapol Yellow PO-227
2,2'-((3,3'-Dichloro-1,1'-biphenyl)-4,4'-diyl)bis(azo)bis(N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide)
CI 21108; Pigment Yellow 83; 2,2'-((3,3'-Dichloro(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide)
Butanamide, 2,2'-((3,3'-dichloro(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo
Butanamide, 2,2'-((3,3'-dichloro(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-
Acetoacetanilide, 2,2''-((3,3'-dichloro-4,4'-biphenylylene)bis(azo))bis(4'-chloro-2',5'-dimethoxy-
Aquafine Yellow E 12
Aquafine Yellow E 12
Butansaeureamid, 2,2'-((3,3'-dichlor(1,1'-biphenyl)-4,4'-diyl)bis(azo))
bis(N-(4-chlor-2,5-dimethoxyphenyl)-3-oxo-
Chromofine Yellow 2700 (L)
Chromofine Yellow 2700(L)
Diarylide Yellow HR
Disazo Yellow
Graphtol Yellow RCL
Graphtol Yellow RCL
Helio Fast Yellow HRN
Imperial yellow
Imperial Yellow
Novoperm Gelb
Novoperm Yellow HR
Novoperm Yellow HR
Novoperm-Gelb HR
Pergantine Yellow 2RN–LA
Pergantine Yellow 2RN-LA
Permanent Yellow HR
Permanent Yellow HR
Permanent Yellow HR 11-1400
Permanent Yellow HR 11-1400
Permanent Yellow HR 70
Permanent Yellow HR 70
Permanent Yellow HR Extra
Permanent Yellow HR Extra
Pigment Yellow 83
Pigmentgelb 83
PV Fast Yellow HR
PV Fast Yellow HR
PV Yellow HR
PV Yellow HR
Sanyo Pigment Yellow IRC
Sanyo Pigment Yellow TRG
Sanyo Pigment Yellow TRG
Segnale Light Yellow 2770
Segnale Light Yellow R
Seikafast Yellow 2770
Seikafast Yellow 2770
Special Yellow HR
Sumitone Fast Yellow HRT
Sumitone Fast Yellow HRT
Symuler Fast Yellow 4173
Symuler Fast Yellow 4173
Symuler Fast Yellow 4181
Symuler Fast Yellow 4181
Symuler Fast Yellow HFS
Symuler Fast Yellow HFS
Vulcan Fast Yellow HR
Vulcan Fast Yellow HR
[IUCLID] 2,2'-[(3,3'-Dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
Panax Yellow 3RH
Panax Yellow 3R
P.Y.83
PY 83
C.I. Pigment Yellow 13 (7CI,8CI)
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide
Benzidine Yellow 13
Benzidine Yellow 20544
Benzidine Yellow GE
Benzidine Yellow GR
Benzidine Yellow Lemon 12221
C.I. 21100
Cromophtal Yellow HG
Dainichi Benzidine Yellow 2GR
Diarylide Yellow
Disazo Yellow
Discoall K 6820
Elkon Fast Yellow GR
Flexiverse Yellow YFD 1303
Graphtol Yellow RGS
Helio Fast Yellow GRF
Helio Fast Yellow GRN
Hostafine Yellow GR
Hostaperm Yellow GR
Irgalite Yellow B 3L
Irgalite Yellow BAW
Irgalite Yellow BAWX
Irgalite Yellow BGW
Irgalite Yellow BKW
Irgalite Yellow LBG
Irgalite Yellow LBIW
Irgaplast Yell
pigment yellow 83
5567-15-7
CI PIGMENT YELLOW 83
PIGMENTYELLOW83
UNII-67HO7X7FV3
67HO7X7FV3
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)- 3-oxobutyramide] PY-83
2-[[2-chloro-4-[3-chloro-4-[[1-(4-chloro-2,5-dimethoxyanilino)-1,3-dioxobutan-2-yl]diazenyl]phenyl]phenyl]diazenyl ]-N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide
CI 21108
2,2'-((3,3'-Dichloro(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(N-(4-chloro-2,5-dimethoxyphenyl)- 3-oxobutyramide)
Butanamide, 2,2′-[(3,3′-dichloro[1,1′-biphenyl]-4,4′-diyl)bis(azo)]bis[N-(4-chloro-2) ,5-dimethoxyphenyl)-3-oxo-
2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis{N-[4-chloro-2,5-bis(methyloxy) phenyl]-3-oxobutanamide}
Butanamide, 2,2'-((3,3'-dichloro(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(N-(4-chloro-2,5-dimethoxyphenyl) )-3-oxo-
EINECS 226-939-8
CI 21108
EC 226-939-8
Pigment yellow 83, tech.
Butanamide, 2,2'-((3,3'-dichloro-1,1'-biphenyl)-4,4'-diyl)bis(azo)bis(N-(4-chloro-2,5-) dimethoxyphenyl)-3-oxo-
SCHEMBL306830
DTXSID1021453
HY-D0283
Pigment Yellow 83, Technical grade
MFCD00071958
2,2'-((3,3'-Dichloro-1,1'-biphenyl)-4,4'-diyl)bis(azo)bis(N-(4-chloro-2,5-dimethoxyphenyl) -3-oxobutanamide)
Acetoacetanilide, 2,2”-((3,3′-dichloro-4,4′-biphenylylene)bis(azo))bis(4′-chloro-2′,5′-dimethoxy-
CS-0010186
F21285
567P157
A857611
W-109157
Q16977693
Butanamide, 2,2′-((3,3′-dichloro(1,1′-biphenyl)-4,4′-diyl)bis(2,1-diazenediyl))bis(N-(4-chloro-2) ,5-dimethoxyphenyl)-3-oxo-
Butanamide,2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl) )-3-oxo-
PY-83
21108
C.I. 21108
Pigment Yellow 83
PIGMENT YELLOW 83
Permanent Yellow HR
permanent yellow hr
C.I.Pigment Yellow83
Solid yellow 2 gs - 2
C.I. Pigment Yellow 83
FAST BRILLIANT YELLOW HR
2,2'-[(3,3'-Dichloro-1,1'-biphenyl-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[n-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
2-[2-chloro-4-[3-chloro-4-[1-[(4-chloro-2,5-dimethoxy-phenyl)carbamoyl]-2-oxo-propyl]azo-phenyl]phenyl]azo-N-(4-chloro-2,5-dimethoxy-phenyl)-3-oxo-butanamide
C.I. Pigment Yellow 83
2,2'-{(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis[(E)diazene-2,1-diyl]}bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)di(E)-2,1-diazenediyl]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-
Acetoacetanilide,2,2''-[(3,3'-dichloro-4,4'-biphenylylene)bis(azo)]bis[4'-chloro-2',5'-dimethoxy-(7CI,8CI)
Butanamide,2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-(9CI)
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide
Aquafine Yellow E 12
C.I. 21108
C.I. Pigment Yellow 83
Colanyl Yellow HRD
FG 1842
HR 70Yellow
Helio Fast Yellow HRN
Hydrocolor Yellow
Imperial yellow
ImperonGolden Yellow K-RN
Lionol Yellow 1805G
Lionol Yellow1823G
Lionol Yellow FG 1842
Lionol Yellow NBR
Microlith Yellow 2R-A
Microlith Yellow 2R-K
Novoperm Yellow HR
NovopermYellow HR 70
Novoperm yellow HR 02
PV Yellow HR
Pergantine Yellow 2RN-LA
Permanent Yellow HR
Permanent Yellow HR 70
Permanent Yellow HR Extra;
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
C.I. 21108
Permanent Yellow HR


PIGMENT YELLOW 83

Pigment Yellow 83 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 83 is a diarylide-based pigment, characterized by its stability and non-toxic nature.
The chemical formula for Pigment Yellow 83 is C36H34Cl2N6O4, and it is commonly used in various industrial applications due to its superior properties.

CAS Number: 5567-15-7
EC Number: 226-939-8

Synonyms: Diarylide Yellow 83, Permanent Yellow HR, CI Pigment Yellow 83, Fast Yellow HR, Hansa Yellow 83, Permanent Yellow 83, Benzidine Yellow 83, Hansa Yellow HR, Irgazin Yellow HR, Hostaperm Yellow HR, Fast Yellow 83, Benzidine Yellow HR, Diarylide Yellow HR, CI 21108, Fast Light Yellow 83, Permanent Yellow HR, Benzidine Yellow HR, Hansa Yellow 5GX, Irgazin Yellow 83, Hostaperm Yellow 83, Diarylide Yellow HR, CI Pigment Yellow HR, Permanent Yellow 83GX, Fast Yellow HR, Benzidine Yellow 5GX, CI Pigment Yellow 5GX, Irgazin Yellow HR, Fast Yellow GX, Hansa Yellow GX, Hostaperm Yellow GX, Permanent Yellow 5GX, CI Pigment Yellow 5G



APPLICATIONS


Pigment Yellow 83 is widely used in the formulation of paints and coatings, providing excellent color strength and opacity.
Pigment Yellow 83 is essential in the manufacture of high-performance industrial coatings.
Pigment Yellow 83 is utilized in decorative coatings for residential and commercial buildings.

Pigment Yellow 83 is a preferred pigment for packaging inks due to its bright color.
Pigment Yellow 83 is used in automotive coatings for its excellent durability.
Pigment Yellow 83 is found in the production of colored pencils and crayons, contributing to bright and vivid hues.

Pigment Yellow 83 is used in water-based paints for its stability and brightness.
Pigment Yellow 83 is a key component in solvent-based paints and coatings.
Pigment Yellow 83 is used in textile printing to dye fabrics in vibrant yellow hues.

Pigment Yellow 83 is employed in the production of rubber materials for its color fastness.
Pigment Yellow 83 is used in the manufacturing of synthetic fibers.
Pigment Yellow 83 is used in the cosmetic industry for products like nail polish.

Pigment Yellow 83 is used in the creation of artist paints and materials.
Pigment Yellow 83 is a key component in the production of plastics, contributing to vibrant and long-lasting colors in various plastic products.
Pigment Yellow 83 is utilized in the formulation of adhesives and sealants, providing consistent coloring and stability.

Pigment Yellow 83 is applied in the creation of specialty coatings for various industrial applications, ensuring durability and color retention.
Pigment Yellow 83 is used in the production of artist paints, providing brilliant and lasting colors for artworks.
Pigment Yellow 83 is essential in the creation of high-quality printing inks.

Pigment Yellow 83 is used in the production of rubber products, ensuring durable and consistent coloring.
Pigment Yellow 83 is employed in the automotive industry, used in high-performance coatings and finishes.
Pigment Yellow 83 is utilized in the production of wood stains and finishes, enhancing the appearance of wood surfaces.

Pigment Yellow 83 is found in the manufacture of specialty coatings for industrial applications.
Pigment Yellow 83 is utilized in the formulation of adhesives and sealants.
Pigment Yellow 83 is a key ingredient in the production of plastic colorants.

Pigment Yellow 83 is employed in the textile industry to dye fabrics.
Pigment Yellow 83 is used in the rubber industry for coloring rubber products.
Pigment Yellow 83 is essential in the production of artist materials.

Pigment Yellow 83 is a vital component in water-based and solvent-based systems.
Pigment Yellow 83 is applied in the creation of high-performance industrial products.
Pigment Yellow 83 is used in the formulation of household and industrial cleaning products.

Pigment Yellow 83 is utilized in the production of specialty coatings for electronic devices.
Pigment Yellow 83 is found in the creation of specialty inks for various applications.
Pigment Yellow 83 is used in the production of ceramic and glass products.

Pigment Yellow 83 is applied in the creation of coatings for metal surfaces.
Pigment Yellow 83 is utilized in the formulation of coatings for plastic products.
Pigment Yellow 83 is essential in the production of coatings for wood surfaces.

Pigment Yellow 83 is used in the formulation of high-performance inks.
Pigment Yellow 83 is applied in the creation of coatings for automotive applications.
Pigment Yellow 83 is utilized in the production of specialty adhesives and sealants.

Pigment Yellow 83 is found in the manufacture of coatings for industrial machinery.
Pigment Yellow 83 is employed in the creation of specialty coatings for various substrates.
Pigment Yellow 83 is used in the formulation of high-performance coatings for various applications.

Pigment Yellow 83 is a key component in the production of specialty inks for flexographic and gravure printing.
Pigment Yellow 83 is used in the creation of specialty inks for digital printing.
Pigment Yellow 83 is essential in the production of high-performance industrial products.

Pigment Yellow 83 is utilized in the manufacture of environmentally friendly industrial products.
Pigment Yellow 83 is used in the creation of water-based and solvent-based products.
Pigment Yellow 83 is a critical ingredient in the formulation of specialty coatings for metal and plastic surfaces.



DESCRIPTION


Pigment Yellow 83 is a high-performance organic pigment known for its brilliant yellow color and excellent lightfastness.
Pigment Yellow 83 is a diarylide-based pigment, characterized by its stability and non-toxic nature.

Pigment Yellow 83 is a versatile organic compound with the chemical formula C36H34Cl2N6O4.
Pigment Yellow 83 is insoluble in water, making it ideal for use in solvent-based systems.
Pigment Yellow 83 provides excellent heat stability, making it suitable for high-temperature applications.

Pigment Yellow 83 is known for its strong tinting strength and high opacity, ensuring vibrant and long-lasting colors.
Pigment Yellow 83 is compatible with a wide range of resins and polymers, enhancing its versatility in different formulations.
Pigment Yellow 83 is widely used in the coatings, plastics, inks, and textiles industries, among others.

Pigment Yellow 83's non-toxic nature makes it safe for use in applications involving food contact materials and children's products.
Pigment Yellow 83 offers excellent weather resistance, making it suitable for outdoor applications.
Pigment Yellow 83 is known for its ease of dispersion, ensuring uniform coloring in various systems.

Pigment Yellow 83's brilliant yellow hue makes it a preferred choice in the creation of bright and vibrant products.
Pigment Yellow 83 is an important precursor in the creation of high-performance coatings and inks.
Pigment Yellow 83 is essential in the manufacture of durable and vibrant colored products.



PROPERTIES


Chemical Formula: C36H34Cl2N6O4
Common Name: Pigment Yellow 83
Molecular Structure: C36H34Cl2N6O4
Molecular Weight: 655.62 g/mol
Appearance: Bright yellow powder
Density: 1.4 g/cm³
Melting Point: 330°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water
Lightfastness: Excellent
Heat Stability: High
Opacity: High
Tinting Strength: Strong
Weather Resistance: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Pigment Yellow 83 is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust.
Do not eat, drink, or smoke while handling Pigment Yellow 83.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Pigment Yellow 83 in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust may be present.


Storage:

Temperature:
Store Pigment Yellow 83 at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Pigment Yellow 83 away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Pigment Yellow 83 to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.

PINE ESSENTIAL OIL
Pine essential oil is derived from the needles of the Pine Tree, commonly recognized as the traditional Christmas tree.
The scent of Pine essential oil is known for having a clarifying, uplifting, and invigorating effect.
Pine essential oil is distilled from the needles of the Scots pine tree.



Essential oil of pine, Yarmor



Known to mankind for centuries, pine needle essential oil was used by the Romans and Ancient Greeks to treat muscular aches and pains.
Pine essential oil is clear in colour with a fresh forest scent with balsamic undertones.
Pine essential oil is a fantastic natural ingredient but needs to be used with a little caution.


Essential oils can sensitise skin and shouldn't be applied to the skin directly or consumed.
Made from pine trees, Pine essential oil offers numerous purported health benefits and is notable for its strong woody scent.
While pine tree oil may offer some benefits, there’s also possible side effects to consider, just like with any other type of essential oil.


Learn the pros and cons so that you can best decide whether pine tree essential oil is worth trying.
Pine essential oil is produced from the pinus sylvestris that belongs to Pinaceae family.
Pinus sylvestris is also referred as forest pine.


Pine essential oil is widely used for relieving sexual and physical fatigue.
Furthermore, Pine essential oil is also used to improve circulation.
There are numerous health benefits associated with Pine essential oil, which the medical practitioners are trying their level best to unravel.


Pine essential oil is one of the most used essential oils for aromatherapy and hence its contribution for making numerous aromatherapy preparations is increasing tremendously.
The health benefits of Pine essential oil are attributed to its comforting properties like aromatic, antiseptic, antibacterial and diuretic.


Pine essential oil has sweet & Pleasant with piney touch.
Pine essential oil is a colorless to light yellow clear liquid.
Pine essential oil is a derivative of pine tree needles, which are known for their strong aroma.


In fact, one sniff of Pine essential oil might remind you of a Christmas tree.
It is 100% pure Pine essential oil obtained by water vapor distillation from the leaves of the pine tree.
Pine essential oil is an essential oil obtained from a variety of species of pine, particularly Pinus sylvestris.


Typically, parts of the trees that are not used for lumber — stumps, etc. — are ground and subjected to steam distillation.
As of 1995, synthetic Pine essential oil was the "biggest single turpentine derivative."
Synthetic Pine essential oils accounted for 90% of sales as of 2000.


Pine Essential Oil is useful in treating various skin problems due to its strong cleansing capacities including psoriasis, acne, boils, eczema and itching skin while it can also help to improve skin pH balance, smoothen, renew and promote shiny skin.
The antioxidant properties of Pine essential oil helps to free skin from radicals attack to prevent premature aging, wrinkles and sagging skin.


For hair, Pine essential oil is also a natural remedy to treat dryness and dandruff.
Pine essential oil is refreshing and energizing.
Pine essential oil is mood uplifting, and helps relieve fatigue.


Pine essential oil increases physical strength, improves mental clarity and memory, and has a purifying effect on the body.
Pine essential oil is commonly used in household cleansers as a disinfectant that can also strengthen the immune system and deodorize any environment.
Pine essential oil is purifying, aids detoxification, and is beneficial for dry and itchy skin.


Pine essential oil is used Cleansing, clearing, fortifying.
Pine essential oil is an invigorating oil which is great to clear the air
Pine essential oil is used a reviving and refreshing oil for the mind & body.


A popular choice of Pine essential oil used in massage to help soothe sore muscles; often found in athletic blends due to its reviving scent.
Pine essential oil is also a good choice of oil to have in the burner if you're suffering from a cold or if you want to clear the air.
Pine essential oil's beautifully refreshing, and uplifting scent is unmistakable and loved by many.


When vaporised can create the image of taking a walk through a coniferous forest!
The uses of Pine essential oil are rooted within folk lore history; it is believed that Pine needles have been used for centuries in Europe to help treat various muscular and respiratory conditions.


Pine essential oil is extracted from the needles and twigs of various pine tree species.
Pine essential oil has a fresh, woody, and earthy scent and is known for its invigorating and purifying properties.
Pine essential oil’s invigorating scent helps revive a tired mind and restore a sense of strength and vigour.


Pine essential oil is used as a good choice in household cleaning blends and is excellent diffused to deodorize, freshen and purify the air.
Pine essential oil helps clear the air both emotionally and practically.
Pine essential oil is obtained from the needles, top twigs and cones of the Scots pine.


Pine essential oil is steam distilled from the cones and needles of pine trees also known as Scotch pine.
Pine essential oil has a clean, refreshing, and woodsy aroma that provides a great breathing experience.
Pine essential oil is ideal to be used in diffusers to make a positive and energizing atmosphere.


Pine Essential Oil or Pinus sylvestris leaf oil helps preserve the integrity of the skin and hair against oxidative processes and helps improve general circulation.
Aura Cacia Pine Essential Oil typically comes from Bulgaria, Hungary and Romania.


The species from which we produce the Pine essential oil, Pinus sylvestris, is appropriate for home and body care.
Other pine species such as Pinus mugo or Pinus palustris (which is found in turpentine) can be irritating to the senses.
Pine essential oil is produced by steam distillation of the needles, twigs and bark.


Pine essential oil’s familiar aroma brings invigorating and refreshing properties for the body and mind and powerful antiseptic activity.
Contrary to common perceptions, Pine Essential Oil does not have a Christmas tree-like scent.
Pine essential oil is standardised for a minimum of 85% total terpene alcohol content.


Pine essential oil is steam distilled from the needle and twigs of Pinus massoniana tree.
Pine essential oil is strong fresh, woody, balsamic, and clean.



USES and APPLICATIONS of PINE ESSENTIAL OIL:
Used in aromatherapy applications, Pine essential oil positively impacts the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.
Used topically, Pine essential oil is reputed to soothe itchiness, inflammation, and dryness, control excessive perspiration, prevent fungal infections, protect minor abrasions from developing infections, slow the appearance of signs of aging, and enhance circulation.


When applied to the hair, Pine essential oil is reputed to cleanse, enhance the hair’s natural smoothness and shine, contribute moisture, and protect against dandruff as well as lice.
Used medicinally, Pine essential oil is reputed to support immune function, clear the respiratory tract, address symptoms of colds, coughs, sinusitis, asthma, and the flu, and facilitate the healing of infections.


Used in massage applications, Pine essential oil is known to soothe inflammation, soreness, aches, pain, and gout; to stimulate and enhance circulation; to facilitate the healing of scratches, cuts, wounds, and burns; to promote the regeneration of new skin; to reduce pain; to relieve muscle fatigue; to promote the body’s detoxification; to maintain the health and function of the urinary tract and the kidneys; and to regulate body weight.


Used topically, such as in cosmetics, the antiseptic and antimicrobial properties of Pine essential oil are known to help soothe skin conditions characterized by itchiness, inflammation, and dryness, such as acne, eczema, and psoriasis.
These properties combined with Pine essential oil's ability to help control excessive perspiration, may help prevent fungal infections, such as Athlete’s Foot.


Pine essential oil is also known to effectively protect minor abrasions, such as cuts, scrapes, and bites, from developing infections.
Its antioxidant properties make Pine essential oil ideal for use in natural formulations intended to slow the appearance of signs of aging, including fine lines, wrinkles, sagging skin, and age spots.


Furthermore, Pine essential oil's circulation-stimulating property promotes a warming effect.
When applied to the hair, Pine Essential Oil is reputed to exhibit an antimicrobial property that cleanses to remove bacteria as well as a build-up of excess oil, dead skin, and dirt.


This helps prevent inflammation, itchiness, and infection, which in turn enhances the hair’s natural smoothness and shine.
Pine essential oil contributes moisture to eliminate and protect against dandruff, and it nourishes to maintain the health of the scalp and strands.
Pine Essential Oil is also one of the oils known to protect against lice.


Used medicinally, Pine Essential Oil is reputed to exhibit antimicrobial properties that support immune function by eliminating harmful bacteria, both airborne and on the skin’s surface.
By clearing the respiratory tract of phlegm and soothing other symptoms of colds, coughs, sinusitis, asthma, and the flu, Pine essential oil's expectorant and decongestant properties promote easier breathing and facilitate the healing of infections.


Used in massage applications, Pine essential oil is known to soothe muscles and joints that may be afflicted with arthritis and rheumatism or other conditions characterized by inflammation, soreness, aches, and pain.
By stimulating and enhancing circulation, Pine essential oil helps facilitate the healing of scratches, cuts, wounds, burns, and even scabies, as it promotes the regeneration of new skin and helps reduce pain.


Pine essential oil is also reputed to help relieve muscle fatigue.
Additionally, Pine essential oil's diuretic properties help promote the body’s detoxification by encouraging the expulsion of pollutants and contaminants, such as excess water, urate crystals, salts, and fats.


This helps maintain the health and function of the urinary tract and the kidneys.
This effect also helps regulate body weight.
COSMETIC uses of Pine essential oil: Anti-Inflammatory, Anti-Oxidant, Deodorant, Energizing, Cleansing, Moisturizing, Refreshing, Soothing, Circulation-Stimulating, Smoothing


ODOROUS uses of Pine essential oil: Calming, Clarifying, Deodorant, Energizing, Focus-Enhancing, Freshening, Insecticidal, Invigorating, Uplifting
MEDICINAL uses of Pine essential oil: Antibacterial, Antiseptic, Anti-Fungal, Anti-Inflammatory, Antibacterial, Analgesic, Decongestant, Detoxifying, Diuretic, Energizing, Expectorant, Soothing, Stimulating, Immune-Enhancing


By diffusing Pine essential oil, whether on its own or in a blend, indoor environments benefit from the elimination of stale odors and harmful airborne bacteria, such as those that cause colds and the flu.
To deodorize and freshen a room with the crisp, fresh, warm, and comforting aroma of Pine Essential Oil, add 2-3 drops to a diffuser of choice and allow the diffuser to run for no more than 1 hour.


This helps to reduce or clear nasal/sinus congestion.
Alternatively, Pine essential oil may be blended with other essential oils that have woody, resinous, herbaceous, and citrusy aromas.
In particular, Pine essential oil blends well with the oils of Bergamot, Cedarwood, Citronella, Clary Sage, Coriander, Cypress, Eucalyptus, Frankincense, Grapefruit, Lavender, Lemon, Marjoram, Myrrh, Niaouli, Neroli, Peppermint, Ravensara, Rosemary, Sage, Sandalwood, Spikenard, Tea Tree, and Thyme.


To create a Pine essential oil room spray, simply dilute Pine essential oil in a glass spray bottle filled with water.
This can be sprayed around the house, in the car, or in any other indoor environment in which a considerable amount of time is spent.
These simple diffuser methods are reputed to help purify indoor environments, promote mental alertness, clarity, and positivity, and to enhance energy as well as productivity.


This makes Pine essential oil ideal for diffusion during tasks that require increased focus and awareness, such as work or school projects, religious or spiritual practices, and driving.
Diffusing Pine essential oil also helps soothe coughing, whether it is linked to a cold or to excessive smoking.


Pine essential oil is also believed to ease symptoms of hangovers.
Massage blends enriched with Pine Essential Oil are also reputed to have the same effects on the mind, helping to promote clarity, ease mental stresses, strengthen attentiveness, and improve memory.


For a simple massage blend, dilute 4 drops of Pine essential oil in 30 ml (1 oz.) of a body lotion or a carrier oil, then massage it into areas affected with tightness or soreness caused by physical exertion, such as exercise or outdoor activities.
This is gentle enough for use on sensitive skin and is believed to soothe aching muscles as well as minor skin ailments, such as itching, pimples, eczema, psoriasis, sores, scabies.


In addition, Pine essential oil is also reputed to soothe gout, arthritis, injuries, exhaustion, inflammation, and congestion.
To use this recipe as a natural vapor rub blend that promotes easier breathing and soothes a sore throat, massage Pine essential oil into the neck, chest, and upper back to help reduce congestion and comfort the respiratory tract.


For a hydrating, cleansing, clarifying, and soothing facial serum, dilute 1-3 drops of Pine Essential Oil in 1 teaspoon of a lightweight carrier oil, such as Almond or Jojoba.
This blend is reputed to have purifying, smoothing, and firming qualities.


Pine essential oil's antioxidant properties are reputed to result in skin that feels smoother, suppler, balanced, and younger, while its analgesic properties are reputed to reduce pain and swelling.
For a balancing and detoxifying bath blend that is also reputed to enhance energy as well as metabolic function and speed, dilute 5-10 drops of Pine

Essential Oil in 30 ml (1 oz.) of a carrier oil and add it to a bathtub filled with warm water.
This helps to eliminate infection-causing bacteria and viruses that may be on the skin.
To enhance the health of the hair and the scalp by eliminating fungus-causing bacteria and by soothing itchiness, simply dilute 10-12 drops of Pine essential oil in ½ cup of a regular shampoo that has minimal or no scent.


This simple shampoo blend is believed to help get rid of lice.
With a beautiful refreshing aroma, this Pine essential oil is mainly used during the winter months to help support your respiratory system and ease breathing.


Pine essential oil also helps to ease your muscles after exertion and is often used in sports massage.
Pine essential oil is most useful to relieve mental, physical and sexual fatigue, while having a cleansing and invigorating effect on an area and is great for vapor therapy in a sick room as it promotes healing.


Pine essential oil can be used for cuts and sores, scabies and lice and for excessive perspiration, while its warming properties help with rheumatism, arthritis, gout, muscular aches and pains and it can stimulate circulation.
Pine essential oil can help in cases of bronchitis, asthma, catarrh, coughs, laryngitis, colds and the flu.


Pine essential oil eases breathlessness and sinusitis.
Diffuse and/or apply Pine essential oil topically to desired location to enhance a deep breathing experience.
Use Pine essential oil in DIY cleaning products for a fresh, sparkling home.


Diffuse Pine essential oil during meditation for a grounding and empowering experience.
Add 3─6 drops to a massage oil and apply Pine essential oil to skin to relax tired muscles.
Use Pine essential oil to enjoy the outdoors annoyance free.


Diffuse or apply this uplifting aroma, Pine essential oil, to brighten your day.
Inhale Pine essential oil with Peppermint to help open airways and breathe easily.
As with other essential oils, Pine essential oil has been used in traditional medicine for centuries.


Pine scents and oil extracts are also abundant in everyday items.
These include floor and furniture cleaners, as well as disinfectants and air fresheners.
However, oil extracts are not the same as essential oils because they don’t carry the same medicinal-strength properties.


Essential oils contain multiple chemical compounds that make them so powerful.
As such, essential oils shouldn’t be ingested.
Industrially, Pine essential oil was once used in froth flotation for the separation of mineral from ores.


For example, in copper extraction, Pine essential oil is used to condition copper sulfide ores for froth flotation.
Its benefits can be enjoyed by using Pine essential oil in hair care, skin care and ambient scenting.
Pine essential oil's relaxing, fresh scent can provide positive effects on stress and anxiety problems by refreshing the ambient energy.


Thanks to its antibacterial properties in skin and hair care, Pine essential oil^is preferred to use for problems such as acne, oiliness and dandruff.
Pine essential oil can support hair growth by purifying and nourishing the scalp.
Pine essential oil is also used as a lubricant in small and expensive clockwork instruments.


In alternative medicine Pine essential oil is used in aromatherapy and as a scent in bath oils.
Relieve mental, physical and sexual fatigue, great for vapor therapy in a sick room as Pine essential oil promotes healing, use for cuts and sores, scabies and lice and for excessive perspiration, help with rheumatism, arthritis, gout, muscular aches and pains, help in cases of bronchitis, asthma, catarrh, coughs, laryngitis, colds and flu, help with nervous exhaustion, neuralgia and mental fatigue.


Pine essential oil is extracted from the tree of Pinus Sylvestris.
Pine essential oil is a powerful antiseptic and helps in sinusitis and bronchial conditions.
Pine essential oil positively impacts the mood by clearing the mind of stress.


The Pine tree is easily recognized as the “Christmas Tree”, but it is also commonly cultivated for its wood.
In ancient Egypt, Pine kernels, better known as Pine nuts, were used in culinary applications.
Pine essential oil is commonly used for skin care, and for the support of the musculoskeletal system.


Pine essential oil is also believed to help with stress, anxiety, and emotional balance.
Pine essential oil can be used in a diffuser, added to a carrier oil for massage, or added to bathwater.
Pine essential oil is considered non-toxic, non-irritant and non-sensitizing oil, but should be used in dilution.


Pine essential oil is used in a necklace, it will add freshness and sharpness of mind.
Pine (Pinus sylvestris) essential oil, known for its cleansing, penetrating and invigorating properties, makes a great contribution to a wide variety of home and body care blends.


On its own or blended with other oils, the aroma of pine essential oil can encourage fortitude and strength.
Many common cleaning products use Pine essential oil and as such, the scent is closely associated with these and their powerful cleaning properties.
This makes Pine essential oil ideal for various home care applications.


Diffuse to reduce to relieve anxiety, stress, and depression, while enhancing concentration, focus, and memory.
Dilute with a carrier oil, then apply topically to heal acne and redness, reduce signs of aging, and restore the skin’s natural protective barrier.
Use as a DIY massage oil to reduce inflammation and pain while stimulating blood flow.


Add a few drops to your home cleaning products to sanitize and refresh.
Makes a great DIY wood polish.
Pine essential oil is used analgesic, anti-bacterial, anti-fungal, anti-inflammatory, antiseptic, decongestant, diuretic & expectorant.


Pine essential oil is used Refreshing and stimulating.
Pine essential oil is used as an antiseptic, anti-infectious, astringent.
Pine essential oil is good for rheumatism, muscular pain, bronchial infection, colds, coughs, asthma and sinuses.


Pine essential oil is used Refreshing and therapeutic in bath.
Pine essential oil is used Cosmetics (soaps, balms, creams, lotions etc.), Aromatherapy (diffuser, vaporiser, burner, potpourri etc.), and Household (laundry, housecleaning and room refreshing),


Pine essential oil has a stimulating and refreshing effect on mind fatigue.
As with all essential oils, never use them undiluted on mucus membranes and if applying an Pine essential oil to your skin always perform a patch test (1% ratio) for topical use


-Air fresheners and aromatherapy uses of Pine essential oil:
Pine essential oil extracts are often used in air fresheners for homes, offices, and vehicles.
Essential oils, on the other hand, may be used in aromatherapy to create an uplifting and invigorating atmosphere — not just a nice scent.
Inhaling oils like pine may also have clearing effects in the case of illnesses like the common cold.


-Skin antimicrobial uses of Pine essential oil:
Some proponents claim that Pine essential oil may be used topically (applied to the skin) as an antimicrobial, similar to tea tree oil.
In theory, Pine essential oil could be used for minor skin infections and burns.
However, research indicates that Pine essential oil doesn’t have much antimicrobial activity.
Talk to a doctor before using Pine essential oil for this purpose.


-Aromatherapy:
The aroma of Pine essential oil is often used in aromatherapy to create a calming and soothing atmosphere.
Inhaling the scent of Pine essential oil can help reduce stress, anxiety, and promote relaxation.


-Air freshening:
Pine essential oil has a pleasant and refreshing scent that can be used to naturally freshen the air in your home.
Pine essential oil can be diffused in a room or added to homemade air fresheners to eliminate odours and create a clean ambiance.


-Mood enhancement:
The invigorating scent of Pine essential oil is believed to uplift the mood and promote a sense of positivity.
Diffusing Pine essential oil in your living space can help create a cheerful and uplifting environment.


-Cleaning agent:
Pine essential oil's antimicrobial properties make it a popular ingredient in natural cleaning products.
Pine essential oil's fresh scent can help mask odours while its antimicrobial properties aid in disinfecting surfaces and purifying the air.


-Insect repellent:
Pine essential oil's strong aroma can act as a natural insect repellent, deterring insects and pests from entering your living spaces.
Adding a few drops of Pine essential oil to homemade insect repellent sprays or diffusers can help keep bugs at bay.


-Wood preservation:
Pine essential oil can be diluted and used to treat wooden furniture, floors, and other items.
Pine essential oil's natural properties can help protect wood from pests and decay while imparting a pleasant scent.


-Holiday ambiance:
The scent of Pine essential oil is often associated with the holiday season.
Using Pine essential oil in your home during festive times can create a warm and cozy atmosphere reminiscent of the holiday spirit.


-DIY projects:
Pine essential oil can be incorporated into various
DIY projects, such as homemade candles, soaps, and potpourri.
Pine essential oil's aroma adds a natural touch to these creations.


-Emotional well-being:
Some people find that the scent of Pine essential oil evokes memories of outdoor experiences in nature, which can contribute to a sense of well-being and connection to the natural world.



BENEFITS AND FEATURES OF PINE ESSENTIAL OIL:
*Fresh, woody aroma promotes clear and calm energy
*Pine essential oil acts as a natural expectorant and decongestant to loosen mucus and phlegm
*Anti-inflammatory properties help heal skin irritations and relieve pain
*Pine essential oil treats acne, reduces excess oil production, and reduces signs of aging
*Pine essential oil promotes better breathing and overall respiratory health
*Pine essential oil neutralizes germs and helps support the immune system against contagions
*Pine essential oil improves blood flow and cardiovascular health, may help lower blood pressure
*Naturally repels insects like mosquitoes, ticks, and flies without DEET or other chemicals
*Pine essential oil supports the lymphatic system and adrenal glands for optimal health
*Pine essential oil helps improve cognition, boosting mental clarity and lengthening attention span
*Pine essential oil adds a crisp, clean natural fragrance to home cleaning products



FACTS OF PINE ESSENTIAL OIL:
*Botanical Name: Pinus sylvestris
*Country of Origin: Hungary/Austria/Bulgaria*
*Extraction Method: Steam Distilled
*Plant Part: Needles
*Aroma: Herbal, Woody
*Consistency: Thin



NATURE/ESSENCE - REVIVING AND CLEARING, PINE ESSENTIAL OIL:
Pine essential oil is used in massage blends or compresses to stimulate circulation and revive tired or aching muscles and joints, ease neuralgia and restore vitality.
Pine essential oil also makes a great antiseptic inhalation during coughs and colds to ease congestion in the nose, sinuses and chest, and to open the airways for healthy respiration.



HOW TO USE PINE ESSENTIAL OIL:
Pine essential oil can be used in a number of different ways, including inhalation and topical variations.
Talk to a doctor about the following methods.



USE PINE ESSENTIAL OIL A DIFFUSER:
Diffusing is one of the most popular ways to use essential oils.
You can make a quick, safe room scent by putting a few drops of pine essential oil into a diffuser filled with water.
Once the device is turned on, the diffuser then releases cool steam.



INHALE PINE ESSENTIAL OIL:
If you don’t have a diffuser on hand, you may still reap the aromatic benefits of Pine essential oil through inhalation.
Simply pour a couple of drops on a tissue, and hold the tissue in front of your face while you inhale deeply through your nose.
You can also try holding the bottle of essential oil underneath your nose.



APPLY PINE ESSENTIAL OIL TOPICALLY:
Pine essential oil may be used topically, either through direct application or via a massage.
It’s important to dilute pine essential oil with a carrier oil before applying directly to your skin.
Add a tablespoon of almond, jojoba, or coconut oil to a few drops of pine essential oil.
You can also use this combination for a patch test 24 hours beforehand to make sure you’re not sensitive to pine.



ADD PINE ESSENTIAL OIL SOME TO YOUR BATH:
Essential oils can also be used in the bath.
Add several drops of the Pine essential oil to warm running water.
Watch for slippery surfaces as you get in and out of the tub.



PROPERTIES AS A DISINFECTANT OF PINE ESSENTIAL OIL:
Pine essential oil is used as a cleaning product, disinfectant, sanitizer, microbicide (or microbistat), virucide or insecticide.
Pine essential oil is an effective herbicide where its action is to modify the waxy cuticle of plants, resulting in desiccation.
Pine essential oil is a disinfectant that is mildly antiseptic.

Pine essential oil is effective against Brevibacterium ammoniagenes, the fungi Candida albicans, Enterobacter aerogenes, Escherichia coli, Gram-negative enteric bacteria, household germs, Gram-negative household germs such as those causing salmonellosis, herpes simplex types 1 and 2, influenza type A, influenza virus type A/Brazil, influenza virus type A2/Japan, intestinal bacteria, Klebsiella pneumoniae, odor-causing bacteria, mold, mildew, Pseudomonas aeruginosa, Salmonella choleraesuis, Salmonella typhi, Salmonella typhosa, Serratia marcescens, Shigella sonnei, Staphylococcus aureus, Streptococcus faecalis, Streptococcus pyogenes, and Trichophyton mentagrophytes.



PINE ESSENTIAL OIL BLENDS WELL WITH:
Bergamot, Cedarwood, Citronella, Clary Sage, Coriander, Cypress, Eucalyptus, Frankincense, Grapefruit, Lavender, Lemon, Marjoram, Myrrh, Neroli, Peppermint, Rosemary, White Sage, Sandalwood, Spikenard, Tea Tree, and Thyme.



DIY (DO PINE ESSENTIAL OIL YOURSELF):
1. 12 drops Pine essential oil, 12 drops eucalyptus oil, 12 drops tea tree and 12 drops cajeput oil.
Add to water in 8 oz mist bottle for
Cleaner house spray.
2. Mix 3 – 4 drops of pine essential oil into a bowl of warm water.
Then soak a brush in the mixture before brushing your dog’s coat.



BENEFITS OF PINE ESSENTIAL OIL:
Pine essential oil is believed to have cleansing, stimulating, uplifting, and invigorating effects.
When diffused, Pine essential oil's purifying and clarifying properties are known to positively impact the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.
These qualities also make Pine essential oil beneficial for spiritual practices, such as meditation.



HISTORY OF PINE ESSENTIAL OIL USAGE:
The Pine tree is easily recognized as the “Christmas Tree,” but it is also commonly cultivated for its wood, which is rich in resin and is thus ideal for use as fuel, as well as for making a pitch, tar, and turpentine, substances that are traditionally used in construction and painting.

In folk tales, the height of the Pine tree has led to its symbolic reputation as a tree that loves the sunlight and is always growing taller in order to catch the beams.

This is a belief that is shared throughout many cultures, which also refer to it as “The Master of Light” and “The Torch Tree.”
Accordingly, in the region of Corsica, it is burned as a spiritual offering so that it can emit a source of light.
In some Native American tribes, the tree is called “The Watchman of the Sky.”

In history, the Pine tree’s needles were used as filling for mattresses, as they were believed to have the ability to protect against fleas and lice.
In ancient Egypt, pine kernels, better known as Pine Nuts, were used in culinary applications.
The needles were also chewed to protect against scurvy.

In ancient Greece, Pine was believed to have been used by physicians like Hippocrates to address respiratory ailments.
For other applications, the tree’s bark was also used for its believed ability to reduce symptoms of colds, to calm inflammation and headaches, to soothe sores and infections, and to ease respiratory discomforts.

Today, Pine essential oil continues to be used for similar therapeutic benefits.
Pine essential oil has also become a popular aroma in cosmetics, toiletries, soaps, and detergents.



REDUCED INFLAMMATION OF PINE ESSENTIAL OIL:
Pine essential oil is also touted as having anti-inflammatory effects.
In theory, such effects could do two things:

Ease symptoms of inflammatory skin conditions, such as acne, eczema, and rosacea.
Alleviate pain from related health conditions, such as arthritis and muscle pain.

However, more research is needed on this front.
Pine essential oil has an uplifting aroma that provides a refreshing breathing experience, encourages feelings of positive energy, and repels the influence of negative energy.



USES AND BENEFITS OF PINE ESSENTIAL OIL:
Due to its aroma, Pine essential oil is notable for its uplifting yet clearing scent.
Because of this, Pine essential oil can work as a room scent in a diffuser as well as in cleaning solutions.
The internet is full of anecdotes and articles that claim Pine essential oil can offer more health benefits than just a nice scent.



BODY, PINE ESSENTIAL OIL:
Pine essential oil is most commonly used to treat upper respiratory and sinus infections.
The best oil to use for both dry and wet coughs.
Accelerates the cleansing of the bronchi.

Its expectorant and at the same time very strong antiseptic effect makes Pine essential oil ideal for inhalation in diffusers.
Pine essential oil is perfect for all colds, angina, catarrh and sore throat.
Pine essential oil can be used alone or in combination with other oils.

Thanks to its warming properties, Pine essential oil can soothe rheumatic, sciatica and arthritis pain.
Pine essential oil can be used after mixing with a base oil (e.g. coconut, jojoba, argan or other).
Pine essential oil also has the effect of strengthening the immune system - it increases the body's immune.



BENEFITS OF PINE ESSENTIAL OIL:
*Eases sinusitis and bronchial conditions
*Relieves fatigue and nervous exhaustion
*Eases overexertion and sports injuries



HOW TO USE OF PINE ESSENTIAL OIL:
Add 1-2 drops in a diffuser or in bath water.
Mix 1-2 drops of carrier oil for massage.



FEATURES & BENEFITS OF PINE ESSENTIAL OIL:
*Pine essential oil has a fresh, woodsy aroma
*Shares many of the same properties as Eucalyptus Globulus; the action of both oils is enhanced when blended together
*Pairs well with other essential oils such as Peppermint, Lavender, and Eucalyptus



COMPOSITION OF PINE ESSENTIAL OIL:
Pine essential oil is a higher boiling fraction from turpentine.
Both synthetic and natural Pine essential oilconsists mainly of α-terpineol, a C10 alcohol (b.p. 214–217 °C).

The detailed composition of natural Pine essential oil depends on many factors, such as the species of the host plant.
Synthetic Pine essential oil is obtained by treating pinene with water in the presence of a catalytic amount of sulfuric acid.
This treatment results in hydration of the alkene and rearrangement of the pinene skeleton, yielding terpineols.



PINE ESSENTIAL OIL:
*Pinus sylvestris:
Pines embody the essence of resilience and determination, an arboreal image of 'mind over matter'.
Growing among rocks and stones in inhospitable places where there is almost no soil, exposed to wind and weather, they inspire us to rise above difficulties and persist against the odds.

Their resinous aroma elevates the spirit, clears the mind and makes the feet move lightly along the path.
Their crowns waving gently in the sky above, they exude a lofty air of serenity and spread a sense of inner peace, tranquillity and calm.
Those who are worn with fatigue and stress should make ample use of the refreshing and invigorating power of pines.

In mythology Pines are commonly associated with the dwellings of fairies and gnomes.
They symbolise humility, good fortune and prosperity, fertility and protection.
Their evergreen needles are a certain indication of a potent life force.

In the olden days, farmers sought to transfer this vital energy and protect their animals and kin by pinning some branches above the doors to ward off witchcraft, misfortune, disease and even lightning.


*Traditional:
Pine essential oil is an excellent oil for muscle aches and pains, rheumatism and arthritis, neuralgia, stiffness etc.
Pine essential oil is also useful for respiratory problems like sinusitis and is wonderful in a bath at the onset of a cold or flu, especially when one is feeling achy.
Pine essential oil stimulates the circulation and is useful for numbness, nervous exhaustion, fatigue and listlessness


*Magical:
Pine essential oil can be used for protection and purification, to dispel negative energy and to cleanse a sacred space or ritual objects.
Pine essential oil is sacred to Dionysos and can be used in fertility rites and for prosperity spells or amulets.

Pine essential oil can help gain strength and courage in times of adversity and can be used for healing rituals.
Pine essential oil is ideal in rites of passage and to celebrate the return of the sun at the winter solstice.

Fill your space with the clean, refreshing scent of nature with Pine Essential Oil.
Also known as Scotch Pine, Scots Pine, or Pine Needle essential oil, this oil has a fresh, uplifting, woody scent that calls to mind tranquil forests and cozy Christmas trees.

Pine essential oil benefits include reducing inflammation, neutralizing bacteria and viruses, and eliminating mold and fungi.
Pine essential oil’s an excellent oil to use in home cleaning products because it purifies and leaves surfaces shiny and sweet-smelling.

Pine essential oil also has natural insect-repelling properties, so it can keep pesky bugs like mosquitoes out of your space – without harsh chemicals like DEET.
Diffuse Pine essential oil in your home to purify the air while creating a comfortable atmosphere that promotes balance and stability.

The scent of Pine essential oil can help you focus, enhance memory, and stimulate creativity.
When used for meditation or yoga, Pine essential oil also helps you connect with Mother Earth and clear negative energy.

When diluted with a carrier oil for topical application, you can enjoy anti-aging Pine essential oil benefits while nourishing dry, cracked skin and treating acne.
Try adding a few drops of Pine essential oilto your regular cleanser or moisturizer, then massage into the skin to tone and brighten.
You can also use Pine essential oil with Fractionated Coconut Oil to make a deep-hydrating, clarifying hair mask.



THERE ARE DIFFERENT METHODS OF APPLICATION AND USE OF ESSENTIAL OILS AND ESSENTIAL OIL PREPARATIONS:
SKIN APPLICATION OF PINE ESSENTIAL OIL:
*Facial Use:
A proportion of 99% Carrier Oil and 1% Essential Oil is recommended.
This is equivalent to 2 drops of Essential Oil for every 10 ml of Carrier Oil.

*Body Use:
A proportion of 97% Carrier Oil and 3% Essential Oil is recommended.
This means 6 drops of Essential Oil for every 10 ml of Carrier Oil.



APPLICATION MODE OF PINE ESSENTIAL OIL:
*Diffuser:
The use of diffusers without heat is recommended, such as the ALQVIMIA Flask, since heat can alter the properties of essential oils.
Up to a maximum of 10 drops of Essential Oil Preparation can be used in the diffuser.

*Bath:
Dilute a maximum of 10-15 drops of Essential Oil Preparation in a small amount of milk (vegetable or animal), yogurt, honey, salt or Bath Gel.
Essential oils do not dissolve in water, so they need a vehicle to mix in the bath.


*Inhalation with Steam:
Apply a maximum of 5 drops of Essential Oil Preparation in a container with hot water (approximately 1-2 liters) and inhale, covering the head and the container with a towel, to retain the steam for longer.


*Sauna:
Dilute a maximum of 2 drops of Essential Oil Preparation for every 500 ml of water used in the sauna.

The very symbol of the festive in December, Pine Essential Oil is extracted from Scotch Pine trees of Bulgaria, also known to many as Christmas trees.
This evergreen is traditionally thought of as a symbol of everlasting life which is the reason of decorating them during Christmas.
The bright herbaceous aroma from its needles, and woody notes from its cones and twigs make Pine Essential Oil an acquired scent that is invigorating and simulative.



MOOD, PINE ESSENTIAL OIL:
With its piquant aroma and subtle warm sweetness, Pine Essential Oil can aid in inflammatory and respiratory discomforts, allowing positive energy flow and dissipates pesky feelings.



SUGGESTED USES AND RECIPES OF PINE ESSENTIAL OIL:
*Topical:
• Dilute 1 drop of Pine essential oil with a drop of carrier oil & massage it onto your chest for respiratory & sinus issues.
• Dilute with a carrier oil & massage stressed muscles or joints.

*Aromatic:
• Diffuse 4-5 drops to add an uplifting yet calming & grounding atmosphere.
• Diffuse with Orange Oil & Cinnamon Oil for an instant Christmas scent.



PHYSICAL and CHEMICAL PROPERTIES of PINE ESSENTIAL OIL:
Chemical formula: Mixture
Appearance: Colorless to pale yellow liquid
Density: 0.875 g/cm3 at 25 °C (approximate)
Melting point: 5 °C (41 °F; 278 K)
Boiling point: 195 °C (383 °F; 468 K)
Solubility in water: Insoluble
log P: 1.7
Vapor pressure: 4 mmHg
Appearance: Clear to pale yellow
Odour: Crisp, fresh
Plant part used: Needles, twigs
Extraction method: Steam distillation
Purity: 100%
Solubility: Oil and alcohol
Usage rate:
Skincare : 0.1 - 1%
Soapmaking: 1 - 3 %
Blends well with: Citronella, clary sage, coriander, cypress, eucalyptus,
frankincense, juniper, lavender, myrrh, rosemary, teatree
Vegan: Yes
Palm oil: No
Animal tested: No



FIRST AID MEASURES of PINE ESSENTIAL OIL:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person. Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PINE ESSENTIAL OIL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of PINE ESSENTIAL OIL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of PINE ESSENTIAL OIL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PINE ESSENTIAL OIL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
*Storage class:
Storage class (TRGS 510): 12:
Non Combustible Liquids



STABILITY and REACTIVITY of PINE ESSENTIAL OIL:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available




PINE ESSENTIAL OIL (PINE OIL)
DESCRIPTION:

Pine Essential Oil (Pine Oil) is an essential oil obtained from a variety of species of pine, particularly Pinus sylvestris.
Typically, parts of the trees that are not used for lumber — stumps, etc. — are ground and subjected to steam distillation.
As of 1995, synthetic pine oil was the "biggest single turpentine derivative."
Synthetic pine oils accounted for 90% of sales as of 2000.

CAS Number: 8002-09-3

SYNONYMS OF PINE ESSENTIAL OIL (PINE OIL) :
Essential oil of pine
Yarmor

Discover the essential oil of Sylvestre pine from EssentiCiagua, an artisanal product extracted from Pinus Sylvestris.
Pine Essential Oil (Pine Oil), originally from France, is recognized for its effectiveness on the respiratory tract and its ability to fight ENT problems, while stimulating immunity.

Sylvestre pine essential oil is particularly effective in relieving the symptoms of cold, bronchitis and cough, thanks to its antiseptic and expectorant properties.
Pine Essential Oil (Pine Oil) helps to clear the airways, providing natural relief.

In case of sinusitis, its inhalation can reduce inflammation and nasal size.
Pine Essential Oil (Pine Oil) is also useful for relieving pain and inflammation linked to arthritis, osteoarthritis, rheumatism, as well as to treat headache, migraines, sciatica and neuralgia thanks to its analgesic and anti-inflammatory properties.

Sylvestre pine oil is also appreciated for its stimulating and invigorating effect, making it ideal for fighting physical fatigue.
In meditation, its wooded aroma creates an environment conducive to deep relaxation and spiritual awakening.
Choosing the essential oil of Essenciagua Sylvestre Pine is opting for a quality product, developed with care and respect for the environment, combining the therapeutic benefits of Sylvestre Pin with sustainable production


Pine essential oil is distilled from the needles of the Scots pine tree.
Known to mankind for centuries, pine needle essential oil was used by the Romans and Ancient Greeks to treat muscular aches and pains.

Pine needle essential oil is clear in colour with a fresh forest scent with balsamic undertones.
Pine needle essential oil is a fantastic natural ingredient but needs to be used with a little caution.
Essential oils can sensitise skin and shouldn't be applied to the skin directly or consumed.
Please consult a doctor before use if pregnant and always keep out of reach of children.


Pine essential oil is a derivative of pine tree needles, which are known for their strong aroma.
In fact, one sniff of pine oil might remind you of a Christmas tree.
As with other essential oils, pine has been used in traditional medicine for centuries.

Pine scents and oil extracts are also abundant in everyday items.
These include floor and furniture cleaners, as well as disinfectants and air fresheners.
However, oil extracts are not the same as essential oils because they don’t carry the same medicinal-strength properties.

Essential oils contain multiple chemical compounds that make them so powerful.
As such, essential oils shouldn’t be ingested.


Pine Essential Oil (Pine Oil) is produced from the pinus sylvestris that belongs to Pinaceae family. Pinus sylvestris is also referred as forest pine.
Pine Essential Oil (Pine Oil) is widely used for relieving sexual and physical fatigue.
Furthermore, Pine Essential Oil (Pine Oil) is also used to improve circulation.

There are numerous health benefits associated with this oil, which the medical practitioners are trying their level best to unravel.
Pine Essential Oil (Pine Oil) is one of the most used essential oils for aromatherapy and hence its contribution for making numerous aromatherapy preparations is increasing tremendously.
The health benefits of Pine Essential Oil (Pine Oil) are attributed to its comforting properties like aromatic, antiseptic, antibacterial and diuretic.



Pine (Pinus sylvestris) essential oil, known for its cleansing, penetrating and invigorating properties, makes a great contribution to a wide variety of home and body care blends.
On its own or blended with other oils, the aroma of pine essential oil can encourage fortitude and strength.



PINE ESSENTIAL OIL (PINE OIL) USES AND BENEFITS:
Due to its aroma, pine essential oil is notable for its uplifting yet clearing scent.
Because of this, pine essential oil can work as a room scent in a diffuser as well as in cleaning solutions.
The internet is full of anecdotes and articles that claim pine essential oil can offer more health benefits than just a nice scent.
However, most of these claims lack clinical evidence.


Air fresheners and aromatherapy:
Pine oil extracts are often used in air fresheners for homes, offices, and vehicles.
Essential oils, on the other hand, may be used in aromatherapy to create an uplifting and invigorating atmosphere — not just a nice scent.
Inhaling oils like pine may also have clearing effects in the case of illnesses like the common cold.

Skin antimicrobial:
Some proponents claim that pine essential oil may be used topically (applied to the skin) as an antimicrobial, similar to tea tree oil.
In theory, the oil could be used for minor skin infections and burns.
However, research indicates that pine oil doesn’t have much antimicrobial activity.
Talk to a doctor before using pine oil for this purpose.

Reduced inflammation:
Pine essential oil is also touted as having anti-inflammatory effects.

In theory, such effects could do two things:
Ease symptoms of inflammatory skin conditions, such as acne, eczema, and rosacea.
Alleviate pain from related health conditions, such as arthritis and muscle pain.

However, more research is needed on this front.
Other essential oils have in fact been shown to have anti-inflammatory properties.

These include:
• turmeric
• ginger
• frankincense
• peppermint

Pine Essential Oil (Pine Oil) is most useful to relieve mental, physical and sexual fatigue, while having a cleansing and invigorating effect on an area and is great for vapor therapy in a sick room as it promotes healing.

Pine Essential Oil (Pine Oil) can be used for cuts and sores, scabies and lice and for excessive perspiration, while its warming properties help with rheumatism, arthritis, gout, muscular aches and pains and Pine Essential Oil (Pine Oil) can stimulate circulation.

Pine Essential Oil (Pine Oil) can help in cases of bronchitis, asthma, catarrh, coughs, laryngitis, colds and the flu.
Pine Essential Oil (Pine Oil) eases breathlessness and sinusitis.



Pine Essential Oil is derived from the needles of the Pine Tree, commonly recognized as the traditional Christmas tree.

The scent of Pine Essential Oil is known for having a clarifying, uplifting, and invigorating effect.

Used in aromatherapy applications, Pine Essential Oil positively impacts the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.

Used topically, Pine Essential Oil is reputed to soothe itchiness, inflammation, and dryness, control excessive perspiration, prevent fungal infections, protect minor abrasions from developing infections, slow the appearance of signs of aging, and enhance circulation.

When applied to the hair, Pine Essential Oil is reputed to cleanse, enhance the hair’s natural smoothness and shine, contribute moisture, and protect against dandruff as well as lice.

Used medicinally, Pine Essential Oil is reputed to support immune function, clear the respiratory tract, address symptoms of colds, coughs, sinusitis, asthma, and the flu, and facilitate the healing of infections.

Used in massage applications, Pine Essential Oil is known to soothe inflammation, soreness, aches, pain, and gout; to stimulate and enhance circulation; to facilitate the healing of scratches, cuts, wounds, and burns; to promote the regeneration of new skin; to reduce pain; to relieve muscle fatigue; to promote the body’s detoxification; to maintain the health and function of the urinary tract and the kidneys; and to regulate body weight.


HISTORY OF PINE ESSENTIAL OIL (PINE OIL) USAGE:
The Pine tree is easily recognized as the “Christmas Tree,” but it is also commonly cultivated for its wood, which is rich in resin and is thus ideal for use as fuel, as well as for making a pitch, tar, and turpentine, substances that are traditionally used in construction and painting.

In folk tales, the height of the Pine tree has led to its symbolic reputation as a tree that loves the sunlight and is always growing taller in order to catch the beams.
This is a belief that is shared throughout many cultures, which also refer to it as “The Master of Light” and “The Torch Tree.”

Accordingly, in the region of Corsica, it is burned as a spiritual offering so that it can emit a source of light.

In some Native American tribes, the tree is called “The Watchman of the Sky.”
In history, the Pine tree’s needles were used as filling for mattresses, as they were believed to have the ability to protect against fleas and lice.
In ancient Egypt, pine kernels, better known as Pine Nuts, were used in culinary applications.

The needles were also chewed to protect against scurvy.
In ancient Greece, Pine was believed to have been used by physicians like Hippocrates to address respiratory ailments.

For other applications, the tree’s bark was also used for its believed ability to reduce symptoms of colds, to calm inflammation and headaches, to soothe sores and infections, and to ease respiratory discomforts.
Today, Pine Oil continues to be used for similar therapeutic benefits.
Pine Essential Oil (Pine Oil) has also become a popular aroma in cosmetics, toiletries, soaps, and detergents.
This article highlights the various other benefits, properties, and safe uses of Pine Essential Oil.



HOW TO USE PINE ESSENTIAL OIL (PINE OIL):
Pine essential oil can be used in a number of different ways, including inhalation and topical variations.
Talk to a doctor about the following methods.

Use a diffuser:
Diffusing is one of the most popular ways to use essential oils.
You can make a quick, safe room scent by putting a few drops of pine essential oil into a diffuser filled with water.
Once the device is turned on, the diffuser then releases cool steam.
You can purchase a diffuser online.

Inhale it:
If you don’t have a diffuser on hand, you may still reap the aromatic benefits of pine essential oil through inhalation.
Simply pour a couple of drops on a tissue, and hold the tissue in front of your face while you inhale deeply through your nose.
You can also try holding the bottle of essential oil underneath your nose.

Apply it topically:
Pine essential oil may be used topically, either through direct application or via a massage.
It’s important to dilute pine essential oil with a carrier oil before applying directly to your skin.
Add a tablespoon of almond, jojoba, or coconut oil to a few drops of pine essential oil.
You can also use this combination for a patch test 24 hours beforehand to make sure you’re not sensitive to pine.

Add some to your bath:
Essential oils can also be used in the bath. Add several drops of the essential oil to warm running water.
Watch for slippery surfaces as you get in and out of the tub.




Composition:
Pine oil is a higher boiling fraction from turpentine.
Both synthetic and natural pine oil consists mainly of α-terpineol, a C10 alcohol (b.p. 214–217 °C).

The detailed composition of natural pine oil depends on many factors, such as the species of the host plant.
Synthetic pine oil is obtained by treating pinene with water in the presence of a catalytic amount of sulfuric acid.
This treatment results in hydration of the alkene and rearrangement of the pinene skeleton, yielding terpineols.






USES OF PINE ESSENTIAL OIL (PINE OIL):
By diffusing Pine Oil, whether on its own or in a blend, indoor environments benefit from the elimination of stale odors and harmful airborne bacteria, such as those that cause colds and the flu.
To deodorize and freshen a room with the crisp, fresh, warm, and comforting aroma of Pine Essential Oil, add 2-3 drops to a diffuser of choice and allow the diffuser to run for no more than 1 hour.

This helps to reduce or clear nasal/sinus congestion.
Alternatively, it may be blended with other essential oils that have woody, resinous, herbaceous, and citrusy aromas.
In particular, Pine Oil blends well with the oils of Bergamot, Cedarwood, Citronella, Clary Sage, Coriander, Cypress, Eucalyptus, Frankincense, Grapefruit, Lavender, Lemon, Marjoram, Myrrh, Niaouli, Neroli, Peppermint, Ravensara, Rosemary, Sage, Sandalwood, Spikenard, Tea Tree, and Thyme.

To create a Pine Oil room spray, simply dilute Pine Oil in a glass spray bottle filled with water.
This can be sprayed around the house, in the car, or in any other indoor environment in which a considerable amount of time is spent.
These simple diffuser methods are reputed to help purify indoor environments, promote mental alertness, clarity, and positivity, and to enhance energy as well as productivity.

This makes Pine Oil ideal for diffusion during tasks that require increased focus and awareness, such as work or school projects, religious or spiritual practices, and driving.
Diffusing Pine Oil also helps soothe coughing, whether it is linked to a cold or to excessive smoking.
It is also believed to ease symptoms of hangovers.

Massage blends enriched with Pine Essential Oil are also reputed to have the same effects on the mind, helping to promote clarity, ease mental stresses, strengthen attentiveness, and improve memory.
For a simple massage blend, dilute 4 drops of Pine Oil in 30 ml (1 oz.) of a body lotion or a carrier oil, then massage it into areas affected with tightness or soreness caused by physical exertion, such as exercise or outdoor activities.

This is gentle enough for use on sensitive skin and is believed to soothe aching muscles as well as minor skin ailments, such as itching, pimples, eczema, psoriasis, sores, scabies.
In addition, it is also reputed to soothe gout, arthritis, injuries, exhaustion, inflammation, and congestion.
To use this recipe as a natural vapor rub blend that promotes easier breathing and soothes a sore throat, massage it into the neck, chest, and upper back to help reduce congestion and comfort the respiratory tract.

For a hydrating, cleansing, clarifying, and soothing facial serum, dilute 1-3 drops of Pine Essential Oil in 1 teaspoon of a lightweight carrier oil, such as Almond or Jojoba.
This blend is reputed to have purifying, smoothing, and firming qualities.
Its antioxidant properties are reputed to result in skin that feels smoother, suppler, balanced, and younger, while its analgesic properties are reputed to reduce pain and swelling.

For a balancing and detoxifying bath blend that is also reputed to enhance energy as well as metabolic function and speed, dilute 5-10 drops of Pine Essential Oil in 30 ml (1 oz.) of a carrier oil and add it to a bathtub filled with warm water.
This helps to eliminate infection-causing bacteria and viruses that may be on the skin.

To enhance the health of the hair and the scalp by eliminating fungus-causing bacteria and by soothing itchiness, simply dilute 10-12 drops of Pine Oil in ½ cup of a regular shampoo that has minimal or no scent.
This simple shampoo blend is believed to help get rid of lice.

Industrially, pine oil was once used in froth flotation for the separation of mineral from ores.
For example, in copper extraction, pine oil is used to condition copper sulfide ores for froth flotation.

Pine Essential Oil (Pine Oil) is also used as a lubricant in small and expensive clockwork instruments.
In alternative medicine it is used in aromatherapy and as a scent in bath oils.

PROPERTIES AS A DISINFECTANT:
Pine oil is used as a cleaning: product, disinfectant, sanitizer, microbicide (or microbistat), virucide or insecticide.
Pine Essential Oil (Pine Oil) is an effective herbicide where its action is to modify the waxy cuticle of plants, resulting in desiccation.
Pine Essential Oil (Pine Oil) is a disinfectant that is mildly antiseptic.
Pine Essential Oil (Pine Oil) is effective against Brevibacterium ammoniagenes, the fungi Candida albicans, Enterobacter aerogenes, Escherichia coli, Gram-negative enteric bacteria, household germs, Gram-negative household germs such as those causing salmonellosis, herpes simplex types 1 and 2, influenza type A, influenza virus type A/Brazil, influenza virus type A2/Japan, intestinal bacteria, Klebsiella pneumoniae, odor-causing bacteria, mold, mildew, Pseudomonas aeruginosa, Salmonella choleraesuis, Salmonella typhi, Salmonella typhosa, Serratia marcescens, Shigella sonnei, Staphylococcus aureus, Streptococcus faecalis, Streptococcus pyogenes, and Trichophyton mentagrophytes.




PINE ESSENTIAL OIL (PINE OIL) BENEFITS:
Pine Essential Oil (Pine Oil) is believed to have cleansing, stimulating, uplifting, and invigorating effects.
When diffused, its purifying and clarifying properties are known to positively impact the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.

These qualities also make Pine Essential Oil (Pine Oil) beneficial for spiritual practices, such as meditation.
Used topically, such as in cosmetics, the antiseptic and antimicrobial properties of Pine Essential Oil are known to help soothe skin conditions characterized by itchiness, inflammation, and dryness, such as acne, eczema, and psoriasis.
These properties combined with its ability to help control excessive perspiration, may help prevent fungal infections, such as Athlete’s Foot.

Pine Essential Oil (Pine Oil) is also known to effectively protect minor abrasions, such as cuts, scrapes, and bites, from developing infections.
Its antioxidant properties make Pine Oil ideal for use in natural formulations intended to slow the appearance of signs of aging, including fine lines, wrinkles, sagging skin, and age spots.

Furthermore, its circulation-stimulating property promotes a warming effect.
When applied to the hair, Pine Essential Oil is reputed to exhibit an antimicrobial property that cleanses to remove bacteria as well as a build-up of excess oil, dead skin, and dirt.

This helps prevent inflammation, itchiness, and infection, which in turn enhances the hair’s natural smoothness and shine.
Pine Essential Oil (Pine Oil) contributes moisture to eliminate and protect against dandruff, and it nourishes to maintain the health of the scalp and strands.
Pine Essential Oil is also one of the oils known to protect against lice.

Used medicinally, Pine Essential Oil is reputed to exhibit antimicrobial properties that support immune function by eliminating harmful bacteria, both airborne and on the skin’s surface.
By clearing the respiratory tract of phlegm and soothing other symptoms of colds, coughs, sinusitis, asthma, and the flu, its expectorant and decongestant properties promote easier breathing and facilitate the healing of infections.

Used in massage applications, Pine Oil is known to soothe muscles and joints that may be afflicted with arthritis and rheumatism or other conditions characterized by inflammation, soreness, aches, and pain.
By stimulating and enhancing circulation, it helps facilitate the healing of scratches, cuts, wounds, burns, and even scabies, as it promotes the regeneration of new skin and helps reduce pain.
Pine Essential Oil (Pine Oil) is also reputed to help relieve muscle fatigue.

Additionally, its diuretic properties help promote the body’s detoxification by encouraging the expulsion of pollutants and contaminants, such as excess water, urate crystals, salts, and fats.
This helps maintain the health and function of the urinary tract and the kidneys.
This effect also helps regulate body weight.

As illustrated, Pine Essential Oil is reputed to have many therapeutic properties.

The following highlights its many benefits and the kinds of activity it is believed to show:
COSMETIC: Anti-Inflammatory, Anti-Oxidant, Deodorant, Energizing, Cleansing, Moisturizing, Refreshing, Soothing, Circulation-Stimulating, Smoothing
ODOROUS: Calming, Clarifying, Deodorant, Energizing, Focus-Enhancing, Freshening, Insecticidal, Invigorating, Uplifting

MEDICINAL: Antibacterial, Antiseptic, Anti-Fungal, Anti-Inflammatory, Antibacterial, Analgesic, Decongestant, Detoxifying, Diuretic, Energizing, Expectorant, Soothing, Stimulating, Immune-Enhancing


Pine Essential Oil (Pine Oil) is derived from the needles of the pine tree, a coniferous evergreen that is widely known for its fresh scent.
While pine oil is commonly used in household cleaners and air fresheners, it also offers a range of benefits for personal health and well-being. In this article, we will explore the various benefits and uses of pine essential oil.

Respiratory Support:
Pine oil has expectorant properties that make it effective in relieving respiratory conditions such as coughs, colds, and sinus congestion.
Pine Essential Oil (Pine Oil) helps to loosen phlegm and mucus, making it easier to expel from the body. Inhalation of pine oil can also help to clear the airways and promote easier breathing.

Pain Relief:
Pine essential oil has analgesic properties that can help alleviate pain and discomfort.
Pine Essential Oil (Pine Oil) can be applied topically to sore muscles and joints to reduce inflammation and provide relief from conditions like arthritis and rheumatism.
Massaging diluted pine oil onto the affected areas can help relax the muscles and improve circulation.

Natural Disinfectant:
Pine oil is a natural disinfectant with antimicrobial properties.
Pine Essential Oil (Pine Oil) can effectively kill bacteria, viruses, and fungi, making it a great addition to homemade cleaning products.
Mixing pine oil with water and vinegar creates a powerful cleaning solution that can be used to sanitize surfaces in your home without the harmful chemicals found in commercial cleaners.


Mood Enhancer:
The aroma of pine essential oil is known to have a positive impact on mood and emotions. Inhaling the scent of pine oil can help uplift the spirits, reduce stress, and alleviate feelings of anxiety and depression.
Diffusing pine oil in a room or adding a few drops to a bath can create a relaxing and invigorating atmosphere.

Skin Care:
Pine oil has antiseptic properties that can benefit the skin.
Pine Essential Oil (Pine Oil) can help cleanse and purify the pores, making it useful for treating acne and other skin conditions.
Pine oil can also be added to bath water or used in a massage oil to help soothe dry and itchy skin.

Boosts Immune System:
Pine essential oil contains compounds that can help strengthen the immune system.
Pine Essential Oil (Pine Oil) stimulates the production of white blood cells, which are essential for fighting off infections and diseases.
Inhaling the aroma of pine oil or using it in a diffuser can help support your body's natural defense mechanisms.

Improves Cognitive Function:
The scent of pine oil has been found to have cognitive-enhancing effects.
Pine Essential Oil (Pine Oil) can help improve focus, memory, and mental clarity.
Diffusing pine oil in your workspace or adding a few drops to a cotton ball and inhaling it while studying or working can help stimulate your brain and enhance productivity.


Relieves Stress and Anxiety:
Pine essential oil has calming properties that can help reduce stress and anxiety.
The soothing aroma of pine oil can help relax the mind and promote a sense of tranquility.
Adding a few drops of pine oil to a warm bath or using it in a massage oil can create a peaceful and stress-relieving experience.


Natural Deodorizer:
The fresh and invigorating scent of pine oil makes it an excellent natural deodorizer.
You can use pine oil as an ingredient in homemade air fresheners, laundry detergents, or room sprays to eliminate unpleasant odors and create a clean and fresh environment.

Repels Insects:
Pine essential oil is a natural insect repellent.
The strong aroma of pine oil acts as a deterrent for insects, including mosquitoes, flies, and ants.
You can create a natural insect repellent spray by combining pine oil with water and spraying it around your home or outdoor areas to keep pesky bugs at bay.


Hair Care:
Pine oil can also benefit your hair. It has been found to promote hair growth and prevent hair loss.
Adding a few drops of pine oil to your shampoo or creating a hair mask with pine oil can help nourish and strengthen your hair follicles, resulting in healthier and thicker hair.


Supports Digestive Health:
Pine essential oil can support digestive health by promoting proper digestion and relieving digestive issues such as indigestion, bloating, and stomach cramps.
Adding a few drops of pine oil to a carrier oil and massaging it onto your abdomen can help soothe digestive discomfort and improve overall digestive function.

Natural Painkiller:
Pine oil has been used as a natural painkiller for centuries. Its analgesic properties can provide relief from headaches, migraines, and muscle pain.
Diluting pine oil with a carrier oil and gently massaging it onto the affected areas can help alleviate pain and promote relaxation.


Respiratory Health:
In addition to providing respiratory support, pine essential oil can also help prevent respiratory infections.
Its antimicrobial properties help kill bacteria and viruses that can cause respiratory illnesses.
Diffusing pine oil in your home or using it in a steam inhalation can help keep your respiratory system healthy and boost your body's defenses against respiratory infections.


Natural Energy Booster:
If you're feeling tired or lacking energy, pine essential oil can provide a natural energy boost. Inhaling the scent of pine oil can help increase alertness and mental clarity.
Diffusing pine oil or using it in a personal inhaler can help combat fatigue and provide a natural pick-me-up.

Pine Essential Oil (Pine Oil) is important to note that pine essential oil should be used with caution and in moderation.
It is recommended to dilute the oil with a carrier oil before applying it to the skin and to perform a patch test to check for any allergic reactions.
In conclusion, pine essential oil offers a wide range of benefits and uses.

From respiratory support to pain relief, mood enhancement to skin care, immune system boosting to insect repellent, and even hair care to digestive health, this versatile oil can be a valuable addition to your natural health and wellness routine.
Whether you choose to inhale its aroma, apply it topically, or use it in your cleaning regimen, pine oil can help promote a healthier and more balanced lifestyle.



SAFETY INFORMATION ABOUT SOYBEAN WAX (SOYWAX)
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



CHEMICAL AND PHYSICAL PROPERTIES OF PINE ESSENTIAL OIL (PINE OIL):
Chemical formula Mixture
Appearance Colorless to pale yellow liquid
Density 0.875 g/cm3 at 25 °C (approximate)
Melting point 5 °C (41 °F; 278 K)
Boiling point 195 °C (383 °F; 468 K)
Solubility in water Insoluble
log P 1.7
Vapor pressure 4 mmHg
Odour:
Sweet & Pleasant with piney touch.

Product Colour/Appearance:
Colorless to light yellow clear liquid.

Extraction Method:
Steam distillation
Botanical Name: Pinus sylvestris
Method of Extraction and Plant Part: Steam distilled from needles and twigs
Country of Origin: Bulgaria

Common name Pine Oil
Botanical name Pinus spp.
Plant parts used Wood
Extraction method Distillation
Origin New Zealand
Appearance Clear colourless
Odour Description Sweet, pine-woody, balsamic and anisic
Main Constituents Borneol, bornyl acetate, a and b-phallandrene, a and b-pinene and 3-carene
Specific Gravity Min 0.920 Max 0.940
Optical Rotation Min -20 Max +10
Refractive Index Min 1.470 Max 1.490



PINE OIL
DESCRIPTION:
Pine oil is an essential oil obtained from a variety of species of pine, particularly Pinus sylvestris.
Typically, parts of the trees that are not used for lumber - stumps, etc. - are ground and subjected to steam distillation.
As of 1995, synthetic pine oil was the "biggest single turpentine derivative."

CAS Number: 8002-09-3
EINECS: 294-351-9

Synthetic pine oils accounted for 90% of sales as of 2000.
The pine tree, a coniferous tree species, is botanically classified as the Pinus genus from the Pinaceae family.
This unique tree, which grows in five different species in our country and has dozens of different species in the world, stands out with its ability to grow and be very durable for many years.

60% of the forested areas in Turkey is thought to consist of pine trees.
This evergreen tree can be grown in almost any climate and soil type in summer and winter.

While most trees cannot withstand the harsh winter conditions, especially in Northern European countries, pine trees can survive for many years even under these harsh conditions.
This is also the reason why pine trees are seen intensely in mountainous areas and high altitudes.
One of the most well-known features of the pine tree is its cones.

Pine essential oil is a derivative of pine tree needles, which are known for their strong aroma.
In fact, one sniff of pine oil might remind you of a Christmas tree.
As with other essential oils, pine has been used in traditional medicine for centuries.

Pine scents and oil extracts are also abundant in everyday items.
These include floor and furniture cleaners, as well as disinfectants and air fresheners.

However, oil extracts are not the same as essential oils because they don’t carry the same medicinal-strength properties.

Essential oils contain multiple chemical compounds that make them so powerful.
As such, essential oils shouldn’t be ingested.

Pine oil is produced from the pinus sylvestris that belongs to Pinaceae family.
Pinus sylvestris is also referred as forest pine.
Pine oil is widely used for relieving sexual and physical fatigue.

Furthermore, Pine oil is also used to improve circulation.
There are numerous health benefits associated with this oil, which the medical practitioners are trying their level best to unravel.

Pine oil is one of the most used essential oils for aromatherapy and hence its contribution for making numerous aromatherapy preparations is increasing tremendously.
The health benefits of Pine oil are attributed to its comforting properties like aromatic, antiseptic, antibacterial and diuretic.

Pine Oil is an essential oil sourced from Austria, that is steam distilled from the needles of Pinus sylvestris.
Pine is a coniferous evergreen tree that can reach heights of up to 40 meters with long blue-green needles.
Pinus sylvestris is also known as forest pine, Norway pine and Scotch pine.

Pine oil is 100% pure with a crisp forest like scent.
Pine oil is classified as a middle note essential oil and sought after for its fresh fragrance and cleansing properties.
Pine Oil is a desired ingredient in the soaping industry and is also used in skin care products, bath products, massage oils, detergents and disinfectants, or enjoyed in diffusers.

COMPOSITION OF PINE OIL:
Pine oil is a higher boiling fraction from turpentine.
Both synthetic and natural pine oil consists mainly of α-terpineol, a C10 alcohol (b.p. 214–217 °C).
The detailed composition of natural pine oil depends on many factors, such as the species of the host plant.

Synthetic pine oil is obtained by treating pinene with water in the presence of a catalytic amount of sulfuric acid.
This treatment results in hydration of the alkene and rearrangement of the pinene skeleton, yielding terpineols.

USES OF PINE OIL:
Pine oil is most useful to relieve mental, physical and sexual fatigue, while having a cleansing and invigorating effect on an area and is great for vapor therapy in a sick room as Pine oil promotes healing.
Pine oil can be used for cuts and sores, scabies and lice and for excessive perspiration, while its warming properties help with rheumatism, arthritis, gout, muscular aches and pains and Pine oil can stimulate circulation.

Pine oil can help in cases of bronchitis, asthma, catarrh, coughs, laryngitis, colds and the flu.
Pine oil eases breathlessness and sinusitis.

Industrially, pine oil was once used in froth flotation for the separation of mineral from ores.
For example, in copper extraction, pine oil is used to condition copper sulfide ores for froth flotation.
Pine oil is also used as a lubricant in small and expensive clockwork instruments.
In alternative medicine Pine oil is used in aromatherapy and as a scent in bath oils.

Properties as a disinfectant:
Pine oil is used as a cleaning product, disinfectant, sanitizer, microbicide (or microbistat), virucide or insecticide.
Pine oil is an effective herbicide where its action is to modify the waxy cuticle of plants, resulting in desiccation.
Pine oil is a disinfectant that is mildly antiseptic.
Pine oil is effective against Brevibacterium ammoniagenes, the fungi Candida albicans, Enterobacter aerogenes, Escherichia coli, Gram-negative enteric bacteria, household germs, Gram-negative household germs such as those causing salmonellosis, herpes simplex types 1 and 2, influenza type A, influenza virus type A/Brazil, influenza virus type A2/Japan, intestinal bacteria, Klebsiella pneumoniae, odor-causing bacteria, mold, mildew, Pseudomonas aeruginosa, Salmonella choleraesuis, Salmonella typhi, Salmonella typhosa, Serratia marcescens, Shigella sonnei, Staphylococcus aureus, Streptococcus faecalis, Streptococcus pyogenes, and Trichophyton mentagrophytes

MEDICINE:
Pine oil Accelerates metabolism.
Pine oil helps the intestines.
Pine oil is good for rheumatism, joint pain and muscle stiffness.

Hemoroide is good.
Pine oil is also very useful for people with a lack of concentration.
Pine oil Relieves urinary tract infections.

Pine oil is used in Eye health benefits.
Pine oil is Good for the respiratory tract.

HAIR CARE:
Pine oil Reduces hair loss
Pine oil Nourishes and repairs hair roots
Pine oil Provides hair growth

In Hair care, Pine oil gives vitality.
Pine oil destroys dandruff.

SKIN CARE:
Pine oil Has the effect of relaxing the body.
Pine oil helps psoriasis, itching, acne and eczema.

Pine oil prevents wrinkles and signs of aging on the skin.
Pine oil Leaves skin smooth & radiant

FOOD:
Pine oil gives aroma to food.

VETERINARY MEDICINE
Pine oil regulates the system.
Pine oil is Good for the digestive system.

Due to its aroma, pine essential oil is notable for its uplifting yet clearing scent.
Because of this, pine essential oil can work as a room scent in a diffuser as well as in cleaning solutions.

Air fresheners and aromatherapy:
Pine oil extracts are often used in air fresheners for homes, offices, and vehicles.
Essential oils, on the other hand, may be used in aromatherapy to create an uplifting and invigorating atmosphere — not just a nice scent.
Inhaling oils like pine may also have clearing effects in the case of illnesses like the common cold.

Skin antimicrobial:
Some proponents claim that pine essential oil may be used topically (applied to the skin) as an antimicrobial, similar to tea tree oil.
In theory, the oil could be used for minor skin infections and burns.

However, research indicates that pine oil doesn’t have much antimicrobial activity.
Talk to a doctor before using pine oil for this purpose.

Reduced inflammation:
Pine essential oil is also touted as having anti-inflammatory effects.

In theory, such effects could do two things:
Ease symptoms of inflammatory skin conditions, such as acne, eczema, and rosacea.
Alleviate pain from related health conditions, such as arthritis and muscle pain.
However, more research is needed on this front.

Other essential oils have in fact been shown to have anti-inflammatory properties.
These include:
• turmeric
• ginger
• frankincense
• peppermint


HOW TO USE PINE OIL?
Pine essential oil can be used in a number of different ways, including inhalation and topical variations.
Talk to a doctor about the following methods.

Use a diffuser:
Diffusing is one of the most popular ways to use essential oils.
You can make a quick, safe room scent by putting a few drops of pine essential oil into a diffuser filled with water.
Once the device is turned on, the diffuser then releases cool steam.
You can purchase a diffuser online.

Inhale Pine oil:
If you don’t have a diffuser on hand, you may still reap the aromatic benefits of pine essential oil through inhalation.
Simply pour a couple of drops on a tissue, and hold the tissue in front of your face while you inhale deeply through your nose.
You can also try holding the bottle of essential oil underneath your nose.

Apply it topically:
Pine essential oil may be used topically, either through direct application or via a massage.
It’s important to dilute pine essential oil with a carrier oil before applying directly to your skin.
Add a tablespoon of almond, jojoba, or coconut oil to a few drops of pine essential oil.
You can also use this combination for a patch test 24 hours beforehand to make sure you’re not sensitive to pine.

Add some to your bath:
Essential oils can also be used in the bath.
Add several drops of the essential oil to warm running water.
Watch for slippery surfaces as you get in and out of the tub.

Odour:
Sweet & Pleasant with piney touch.

Product Colour/Appearance:
Colorless to light yellow clear liquid.

Extraction Method:
Steam distillation


HISTORY OF PINE OIL USAGE:
The Pine tree is easily recognized as the “Christmas Tree,” but it is also commonly cultivated for its wood, which is rich in resin and is thus ideal for use as fuel, as well as for making a pitch, tar, and turpentine, substances that are traditionally used in construction and painting.

In folk tales, the height of the Pine tree has led to its symbolic reputation as a tree that loves the sunlight and is always growing taller in order to catch the beams.
This is a belief that is shared throughout many cultures, which also refer to it as “The Master of Light” and “The Torch Tree.”
Accordingly, in the region of Corsica, it is burned as a spiritual offering so that it can emit a source of light.
In some Native American tribes, the tree is called “The Watchman of the Sky.”

In history, the Pine tree’s needles were used as filling for mattresses, as they were believed to have the ability to protect against fleas and lice.
In ancient Egypt, pine kernels, better known as Pine Nuts, were used in culinary applications.
The needles were also chewed to protect against scurvy.

In ancient Greece, Pine was believed to have been used by physicians like Hippocrates to address respiratory ailments.
For other applications, the tree’s bark was also used for its believed ability to reduce symptoms of colds, to calm inflammation and headaches, to soothe sores and infections, and to ease respiratory discomforts.

Today, Pine Oil continues to be used for similar therapeutic benefits.
Pine Oil has also become a popular aroma in cosmetics, toiletries, soaps, and detergents.



PINE OIL BENEFITS:
It is believed to have cleansing, stimulating, uplifting, and invigorating effects.
When diffused, its purifying and clarifying properties are known to positively impact the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.
These qualities also make Pine Oil beneficial for spiritual practices, such as meditation.

Used topically, such as in cosmetics, the antiseptic and antimicrobial properties of Pine Essential Oil are known to help soothe skin conditions characterized by itchiness, inflammation, and dryness, such as acne, eczema, and psoriasis.
These properties combined with its ability to help control excessive perspiration, may help prevent fungal infections, such as Athlete’s Foot.
Pine Oil is also known to effectively protect minor abrasions, such as cuts, scrapes, and bites, from developing infections.

Its antioxidant properties make Pine Oil ideal for use in natural formulations intended to slow the appearance of signs of aging, including fine lines, wrinkles, sagging skin, and age spots.
Furthermore, its circulation-stimulating property promotes a warming effect.

When applied to the hair, Pine Essential Oil is reputed to exhibit an antimicrobial property that cleanses to remove bacteria as well as a build-up of excess oil, dead skin, and dirt.
Pine Oil helps prevent inflammation, itchiness, and infection, which in turn enhances the hair’s natural smoothness and shine.
Pine Oil contributes moisture to eliminate and protect against dandruff, and Pine Oil nourishes to maintain the health of the scalp and strands.
Pine Oil is also one of the oils known to protect against lice.

Used medicinally, Pine Oil is reputed to exhibit antimicrobial properties that support immune function by eliminating harmful bacteria, both airborne and on the skin’s surface.
By clearing the respiratory tract of phlegm and soothing other symptoms of colds, coughs, sinusitis, asthma, and the flu, its expectorant and decongestant properties promote easier breathing and facilitate the healing of infections.

Used in massage applications, Pine Oil is known to soothe muscles and joints that may be afflicted with arthritis and rheumatism or other conditions characterized by inflammation, soreness, aches, and pain.
By stimulating and enhancing circulation, it helps facilitate the healing of scratches, cuts, wounds, burns, and even scabies, as it promotes the regeneration of new skin and helps reduce pain.
Pine Oil is also reputed to help relieve muscle fatigue.

Additionally, its diuretic properties help promote the body’s detoxification by encouraging the expulsion of pollutants and contaminants, such as excess water, urate crystals, salts, and fats.
Pine Oil helps maintain the health and function of the urinary tract and the kidneys.
This effect also helps regulate body weight.




SAFETY INFORMATION ABOUT PINE OIL:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

CHEMICAL AND PHYSICAL PROPERTIES OF PINE OIL:
Chemical formula Mixture
Appearance Colorless to pale yellow liquid
Density 0.875 g/cm3 at 25 °C (approximate)
Melting point 5 °C (41 °F; 278 K)
Boiling point 195 °C (383 °F; 468 K)
Solubility in water Insoluble
log P 1.7
Vapor pressure 4 mmHg

Product name Pine Turpentine Oil
Botanical Name Pinus radiata
Harvest time Autumn
Part Used Needles
Method of Extraction Steam Distillation
EINECS CAS 8023-99-2
EINECS 281-679-2
INCI Name Pinus Sylvestris Needles Oil
Chemical content Alpha-pinene, Limonene, Delta-3-carene, Beta-pinene, Camphene, Bornly acetate, Terpinolene, Para-cymene

PINE OIL FACTS:
Botanical name Pinus sylvestris
Plant part Needles and twigs
Extraction method Steam distilled
Colour Colourless to pale yellow
Consistency Thin
Note Top
Strength of aroma Strong
Aromatic scent A forest like aroma which is sweet, crisp and fresh.



PINE OIL
cas no 8006-64-2 Fir oil; Oil of turpentine; Pine oil; Turpentine; L-Turpentine;
PINE OIL
Pine Oil has a strong piny odor and is miscible with alcohol.
Pine Oil a clear colorless to light amber colored liquid.
Pine Oil less dense than water and insoluble in water.

CAS Number: 8002-09-3
EINECS Number: 692-006-0

1093292-01-3,(1R,3Z)-3-(2,2-dimethylpropylidene)cyclohexan-1-ol;(1R,3E)-3-(2,2-dimethylpropylidene)cyclohexan-1-ol;(1S,3E)-3-(2,2-dimethylpropylidene)cyclohexan-1-ol Poly[N-(1-octylnonyl)-9H-carbazole-2,7-diyl], 2086312-08-3, 314270-00-3, 444619-08-3, 8002-09-3.

Pine Oil a complex combination of terpenes produced by the high temperature distillation of oil of turpentine residues or by the catalytic hydration of pinenes.
Composed primarily of isomeric tertiary and secondary cyclic terpene alcohols.
Pine Oil has a fresh, woody, and invigorating aroma reminiscent of the outdoors.

The production of essential oil from Pine Oil has been abandoned.
The needles are probably distilled with those from spruce.
Extractives and their physically modified derivatives.

Pine Oil has a high content of various alcohols.
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents.
They react with Pine Oils and carboxylic acids to form esters plus water.

Oxidizing agents convert them to aldehydes or ketones.
Pine Oil is an aromatic oil derived from the needles of pine trees, primarily from the Pinus genus.
Alcohols exhibit both weak acid and weak base behavior.

They may initiate the polymerization of isocyanates and epoxides.
Pine Oil is a derivative of turpentine obtained by steam distillation of the species Pinus.
Pine Oil has a strong piny odor and is miscible with alcohol.

Pine Oil contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.
They have a relatively low human toxicity level.
They also have a low corrosion level and limited persistence.

Pine Oil is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris.
Pine Oil has fresh, bracing, antibacterial and stimulating properties.
Pine Oil can help to ease muscle aches and pains and help improve circulation.

Pine Oil is ideal for use in inhalations.
Pine Oil has a positive, strengthening effect on both the mind and body.
Pine Oil is refreshing and quickly clears the head.

Pine Oil is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris.
Pine Oil has a strong piny odor and is miscible with alcohol.
Pine Oil contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.

Pine Oil has a supporting and energising effect that is used to relieve mental, physical and sexual fatigue.
Pine Oil supports the respiratory system for clear and cool breathing, and warms and soothes stiff muscles and joints after everyday wear and tear.
As with other Pine Oils, pine has been used in traditional medicine for centuries.

Pine Oil extracts are also abundant in everyday items.
These include floor and furniture cleaners, as well as disinfectants and air fresheners.
Pine Oil extracts are not the same as essential oils because they don’t carry the same medicinal-strength properties.

Pine Oils contain multiple chemical compounds that make them so powerful.
Pine Oils a fresh and resinous fragrance that is reminiscent of forests and brings a sense of grounding and rejuvenation.
Pine Oil is invigorating and cleansing scent is commonly used to create a refreshing and energizing atmosphere.

Pine Oils are highly concentrated, volatile aromatic substances that are obtained from various parts of plants.
They can be found in leaves, roots, flowers, seeds and even bark.
They add aroma to plants, protect them from danger, help them with pollination and are very rich in a lot of different effective and medical substances.

Pine Oil extracts are often used in air fresheners for homes, offices, and vehicles.
Pine Oils, on the other hand, may be used in aromatherapy to create an uplifting and invigorating atmosphere — not just a nice scent.
Pine Oil needle has a forest fragrance and is thus mentally refreshing.

Pine Oil has energizing and mood-elevating properties, providing mental calmness with improved concentration and memory.
Pine Oil is commonly used in households as a cleaner and a disinfectant.
Pine Oil can improve circulation and reduce muscle and joint pain, and inflammation.

Pine Oil is believed to be purifying, aids detoxification, and beneficial for dry and itchy skin.
Pine Oil of pine needles is derived from the plant’s needle like leaves.
The leaves of pine trees are needle like to minimise transpiration and protect against snow.

Pine Oil has a fresh forest smell with pleasant balsamic, sweet, spicy undertones.
Pine Oil is known for its beneficial effects on muscles and joints and the respiratory system.
Pine Oil has a distinctive and robust aroma that is often described as fresh, forest-like, and resinous.

Pine Oil can evoke a sense of cleanliness and vitality.
The composition of Pine Oil can vary depending on the species of pine.
Pine Oil typically contains compounds such as alpha-pinene, beta-pinene, delta-3-carene, and others.

These compounds contribute to the Pine Oil's scent and therapeutic properties.
Pine Oil is known for its antimicrobial properties, which may make it useful for cleaning and disinfecting purposes.
Pine Oil is often used to help clear the respiratory system and ease symptoms of congestion and cough.

Pine Oil may have anti-inflammatory effects, making it potentially beneficial for soothing minor skin irritations.
In aromatherapy, inhaling the scent of Pine Oil is believed to be beneficial for respiratory health.
Pine Oil may help open the airways and provide relief from congestion.

Due to its antimicrobial properties and refreshing scent, Pine Oil is used in natural cleaning products.
Pine Oil can be added to homemade cleaners to impart a pleasant fragrance and enhance the cleaning power.
Pine Oil is often used in aromatherapy to create an uplifting and energizing atmosphere.

Pine Oil may contribute to feelings of alertness and well-being.
Pine Oil can be applied topically for massage, but it's important to use a carrier oil to prevent skin irritation.
Always perform a patch test before applying essential oils directly to the skin.

The fresh and clean scent of Pine Oil makes it a popular choice for natural air fresheners and deodorizers.
Pine Oil is not generally effective against non-enveloped viruses or spores.
Pine Oil will kill the causative agents of typhoid, gastroenteritis, rabies, enteric fever, cholera, several forms of meningitis, whooping cough, gonorrhea and several types of dysentery.

Pine Oil is also effective against several of the leading causes of food poisoning.
Pine Oil is not effective against spore related illneses such as tetanus or anthrax or against non-enveloped viruses such as poliovirus, rhinovirus, hepatitis B or hepatitis C.
Pine Oil has antiseptic and disinfectant properties and is a common ingredient in household cleaning products and air fresheners.

Pine Oil is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris.
Pine Oil has a strong piny odor and is miscible with alcohol.
Pine Oil contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.

Pine Oil is distilled from the needles of the Scots pine tree.
Known to mankind for centuries, Pine Oil needle essential oil was used by the Romans and Ancient Greeks to treat muscular aches and pains.
Pine Oil is clear in colour with a fresh forest scent with balsamic undertones.

Pine Oil is a fantastic natural ingredient but needs to be used with a little caution.
Pine Oils can sensitise skin and shouldn't be applied to the skin directly or consumed.
Please consult a doctor before use if pregnant and always keep out of reach of children.

Pine Oils are increasingly gaining mainstream popularity as possible alternatives to medications.
These plant-derived ingredients are still being studied for their medicinal effects, and pine oil is no exception.
Pine Oil is a derivative of pine tree needles, which are known for their strong aroma.

In fact, one sniff of Pine Oil might remind you of a Christmas tree.
Pine Oil is mainly applied in the production of household detergent, industrial cleaner, high quality ink and paint solvent owing to its pleasant pine smell, notable antimicrobial power and excellent solvency, low concentration ones can be used as foaming agent in ore floatation.
Pine Oil is a phenolic disinfectant.

Pine Oil is generally effective against numerous bacterial strains and enveloped viruses.
Pine Oil disinfectants are relatively inexpensive and widely available.
Pine Oil a large addition of white pine needles to spruce needles tends to lower considerably the ester content of the distilled spruce oil.

May contain terpene hydrocarbons and ethers.
Exact composition varies with production methods and turpentine source.
Contains mainly tertiary and secondary terpene alcohols Produced from the wood of pine trees by extraction or steam distillation.

There are various species of pine trees, and their needles are steam-distilled to extract the Pine Oil.
Pine Oil contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.
Pine Oil is derived from the needles of the Pine Tree, commonly recognized as the traditional Christmas tree.

Melting point: −55 °C(lit.)
Boiling point: 153-175 °C(lit.)
Density: 0.86 g/mL at 25 °C(lit.)
vapor density: 4.84 (−7 °C, vs air)
vapor pressure: 4 mm Hg ( −6.7 °C)
refractive index: n20/D 1.515
Flash point: 86 °F
Odor: at 100.00 %. pine

Pine Oil is known for its decongestant properties.
Inhaling its vapors may help open nasal passages and relieve respiratory congestion.
Pine Oil can be used in steam inhalation or in a diffuser during cold and flu seasons.

Some varieties of Pine Oil, labeled as food-grade, can be used in minimal amounts for flavoring certain dishes.
Pine Oil's crucial to ensure the oil is safe for internal use, and only a tiny amount should be used due to its concentrated nature.
Add a few drops of Pine Oil to a basin of warm water for a refreshing foot soak.

This can be both relaxing and invigorating, and the oil may contribute to foot health.
Create a DIY room spray by combining Pine Oil with other essential oils known for their focus-enhancing properties, such as peppermint or rosemary.
Pine Oil use this spray in workspaces or study areas.

Pine Oil can be added to potpourri or used in sachets to bring the fresh and outdoorsy scent indoors.
This is a natural way to freshen up living spaces.
Bring a portable diffuser or a cloth with a few drops of Pine Oil on outdoor activities like camping or hiking.

The scent can add to the experience and repel insects.
Create a natural room freshener by combining Pine Oil with water in a spray bottle.
Use Pine Oil to freshen the air in home without synthetic fragrances.

Place cotton balls or pieces of fabric scented with Pine Oil in drawers and closets to keep clothes smelling fresh and to deter pests.
Make pine-scented candles by adding Pine Oil to melted candle wax.
This can be a delightful way to enjoy the aroma of pine indoors.

Mix Pine Oil with Epsom salts to create pine-infused bath salts.
Add a handful to your bath for a soothing and aromatic experience.
Create DIY air freshener disks by combining baking soda with Pine Oil.

The scent of Pine Oil is often associated with winter and the holiday season.
Pine Oil is fresh and uplifting aroma is commonly used in seasonal blends and festive aromatherapy.
Some people believe that the inhalation of Pine Oil may have positive effects on cognitive function, including improved focus and mental clarity.

Pine Oil is commonly used in sauna aromatherapy.
Adding a few drops to water in a sauna can enhance the experience with its invigorating scent.
Pine forests are known for their distinctive scent.

Pine Oil can be used recreationally or therapeutically to simulate the experience of being in a pine forest, a practice known as "forest bathing" or shinrin-yoku.
The aroma of Pine Oil is often associated with feelings of freshness and vitality.
In aromatherapy, Pine Oil is sometimes used to provide emotional support and a sense of well-being.

Due to its cleansing properties, Pine Oil can be added to homemade all-purpose cleaners.
Pine Oil not only contributes to the cleaning power but also imparts a pleasant scent.
Pine Oil can be added to a homemade furniture revitalizer or polish to restore and refresh the appearance of wooden furniture.

Pine Oil is a popular choice for making DIY candles.
Pine Oil is fragrance can create a cozy and comforting atmosphere, especially during the colder months.
Inhaling the aroma of Pine Oil is thought by some to have mood-lifting properties, helping to alleviate feelings of fatigue or low energy.

Adding a few drops of Pine Oil to a warm bath can create a spa-like experience and contribute to a sense of relaxation.
Portable inhalers and electric diffusers can be used to enjoy the benefits of Pine Oil aromatherapy on the go or in different rooms of the home.
Experiment with creating seasonal blends by combining Pine Oil with other seasonal scents like citrus, cinnamon, or clove for a festive atmosphere.

Pine Oil has a refreshing sweet-resinous woody aroma and it is said to have a cleansing and invigorating effect.
Pine Oil can help combat fatigue, stimulate circulation and can be used in massage blends for sore aching muscles.
Pine oil is effective in the treatment of respiratory complaints eg. colds, flu, sinusitis and bronchitis and is also used in saunas and steam rooms.

Pine Oil is great for vapour therapy in a sick room as it promotes healing.
Pine Oil can cause allergic reactions, it is very useful to relieve mental, physical and sexual fatigue, while having a cleansing and clearing effect on a room.
Even though Pine Oil can be used in cystitis, hepatitis and prostate problems, as well as to improve circulation and to relieve rheumatism, gout, sciatica and arthritis, it should be done so with care due to the sensitizing nature of this oil.

Pine Oil has a fresh forest smell, is pale yellow in colour and watery in viscosity.
Significant in many early systems of medicine, pine needle essential oil has been used for hundreds of years to protect against illness and infection.
A natural air freshener, Pine Oil can help to protect our health when diffused and can also act as a natural perfume or deodorant to help mask personal odour.

Pine Oil's soothing, cleansing effects make it a popular skin tonic, able to clear up imperfections and calm irritations.
Pine Oil is also a great choice for use in home cleaning sprays due to its powerful antibacterial activity and its refreshing scent.
Pine Oil is commonly recognized as the traditional Christmas Tree.

Pine Oil is clarifying and uplifting oil offers numerous health benefits and it is notable for its strong woody scent.
Pine Oil is commonly used to cleanse, ease and energize the body and mind.
The sweet, fresh and green aroma of Pine Oil is unmistakable, and diffusing it around the home is like taking a walk in a coniferous forest - uplifting, refreshing and highly invigorating.

Pine Oil has a long history of use in folk medicine, and with good reason.
Pine Oil stimulates the body’s metabolic rate and energises all body systems, making it good for convalescence as well as boosting the emotions.
Pine Oil is derived from the needles of the Pine Tree. The scent has a clarifying, uplifting, and invigorating effect, often used in aromatherapy applications.

Pine Oil’s reputed to assist with skin related problems such as soothing itchiness, inflammation, control excessive perspiration, protect minor abrasions from developing infections and slowing the appearance of ageing.
The invigorating and grounding aroma of Pine Oil is believed to have stress-relieving properties.
Diffusing the Pine Oil or inhaling its scent may help promote relaxation and reduce feelings of stress and anxiety.

Pine Oil is sometimes used topically in diluted form for massage to support joint and muscle health. ,
Pine Oil is anti-inflammatory properties may provide relief from minor aches and pains.
Adding a few drops of Pine Oil to hair care products or creating a DIY hair treatment may contribute to a healthy scalp and hair.

Pine Oil is refreshing scent is an additional benefit in hair care formulations.
The aroma of Pine Oil is known to be unpleasant to certain insects.
Pine Oil can be used in natural insect repellent formulations or added to homemade candles and diffusers to help deter insects.

In aromatherapy and meditation, the earthy and grounding aroma of Pine Oil is thought to promote a sense of stability and centering.
Pine Oil can be used alone or in blends for these purposes.
Pine Oil can be added to homemade room sprays and linen spritzers to impart a fresh and clean scent to living spaces and fabrics.

Pine Oil can be incorporated into DIY personal care products, such as soaps, lotions, and bath salts, to provide a natural and uplifting fragrance.
Due to its natural woodsy aroma, Pine Oil can be added to homemade wood polish to clean and shine wooden furniture.
Some varieties of Pine Oil, labeled as safe for internal use and meeting food-grade standards, can be used sparingly as a flavoring agent in culinary applications.

However, Pine Oil's crucial to ensure that the oil is specifically designated for consumption.
In educational or therapeutic settings, the scent of Pine Oil is sometimes used to create a focused and refreshing atmosphere.

Pine Oil's antimicrobial properties make it a natural disinfectant.
Pine Oil can be added to cleaning solutions to help sanitize surfaces in the home.

Uses:
Pine Oil can be added to homemade cleaners to disinfect surfaces and leave a clean fragrance.
When diluted with a Pine Oil, Pine Oil can be applied topically for massages.
Pine Oil is anti-inflammatory properties may help soothe sore muscles and joints.

Pine Oil is used in the formulation of perfumes, colognes, and other personal care products for its fresh and woody fragrance.
Adding a few drops of Pine Oil to a foot soak or foot cream can contribute to foot health and provide a refreshing sensation.
Pine Oil can be incorporated into DIY soaps, lotions, and skincare products for its pleasant scent and potential skin-soothing properties.

Pine Oil's antibacterial properties make it a suitable ingredient for natural deodorants.
Use Pine Oil on hardwood or tile floors for a fresh and clean scent.
Make wax melts by melting soy wax and adding Pine Oil.

Place them in a wax warmer for a long-lasting pine fragrance.
Add a few drops of Pine Oil to liquid hand soap to enjoy the refreshing scent each time wash hands.
Infuse a pine garland with Pine Oil for a fragrant and decorative touch during the holiday season.

Create a linen spray by mixing Pine Oil with water and a small amount of vodka or witch hazel. Spritz it on linens for a fresh scent.
Pine Oil is used topically, Pine Oil is reputed to soothe itchiness, inflammation, and dryness, control excessive perspiration, prevent fungal infections, protect minor abrasions from developing infections, slow the appearance of signs of aging, and enhance circulation.
Pine Oil is used medicinally, Pine Oil is reputed to support immune function, clear the respiratory tract, address symptoms of colds, coughs, sinusitis, asthma, and the flu, and facilitate the healing of infections.

Pine Oil is used in massage applications, Pine Oil is known to soothe inflammation, soreness, aches, pain, and gout; to stimulate and enhance circulation; to facilitate the healing of scratches, cuts, wounds, and burns; to promote the regeneration of new skin; to reduce pain; to relieve muscle fatigue; to promote the body’s detoxification; to maintain the health and function of the urinary tract and the kidneys; and to regulate body weight.
Pine Oil is originally used as a solvent and a disinfectant, it is also deodorizing, anti-bacterial and anti-septic.
Studies are now showing that certain fractions of Pine Oil may stimulate fibroblast growth, which would mean an increase in the turnover of epidermal cells.

Pine Oil is produced by distillation of small pine branches.
Pine Oil may be irritating to the skin and mucous membranes.
Add Pine Oil to homemade potpourri blends for a natural and long-lasting fragrance.

Combine with dried pinecones, citrus peels, and spices for a seasonal mix.
Create natural reed diffusers by combining Pine Oil with a carrier oil (such as sweet almond oil) and placing reed sticks in the mixture.
This provides a continuous release of the pine fragrance in a room.

Infuse pinecones with the scent of Pine Oil by placing them in a bag with a few drops of oil.
Let them sit for some time before using them as decorative or aromatic elements in your home.
Make homemade playdough and add a few drops of Pine Oil for a delightful sensory experience, especially for children.

Create sachets filled with dried herbs, flowers, or cedar chips infused with Pine Oil.
Place these sachets in drawers or closets for a natural and pleasant scent.
Combine Pine Oil with a carrier oil or wood polish to revitalize wooden furniture, leaving it with a fresh and polished appearance.

Add a few drops of Pine Oil to a damp cloth or a dryer ball and toss it into the dryer with your laundry for a natural and refreshing fragrance.
Mix Pine Oil with baking soda and sprinkle it on carpets before vacuuming.
This acts as a natural carpet freshener, eliminating odors and leaving a pleasant scent.

Create cleaning wipes by adding Pine Oil to a solution of water, vinegar, and a small amount of liquid soap.
Use these wipes for cleaning surfaces around the home.
Bring Pine Oil on camping trips for a touch of the outdoors.

Diffuse Pine Oil or apply diluted oil to the skin to repel insects naturally.
Pine Oil with water and use it as a natural pet odor neutralizer.
Spray Pine Oil in pet bedding or areas where odors may be present.

Create wax sachets infused with Pine Oil by melting a mixture of beeswax and coconut oil.
Pour the melted wax into molds, add Pine Oil, and let it solidify.
Pine Oil is used in the following products: washing & cleaning products, air care products, biocides (e.g. disinfectants, pest control products) and polishes and waxes.

Other release to the environment of Pine Oil is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Other release to the environment of Pine Oil is likely to occur from: indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and leather (e.g. gloves, shoes, purses, furniture).

Pine Oil is used in the following products: air care products, coating products, polishes and waxes, washing & cleaning products, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), laboratory chemicals, leather treatment products, paper chemicals and dyes, perfumes and fragrances, pharmaceuticals and textile treatment products and dyes.
Pine Oil is used in the following areas: health services.
Pine Oil is used for the manufacture of: textile, leather or fur, pulp, paper and paper products and machinery and vehicles.

Other release to the environment of Pine Oil is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Pine Oil can also be used for cuts and sores, scabies and lice and for excessive perspiration, while its warming properties help with rheumatism, arthritis, gout, muscular aches and pains and it can stimulate circulation.
Furthermore Pine Oil can help in cases of bronchitis, asthma, catarrh, coughs, laryngitis, colds and flu.

Pine Oil eases breathlessness and sinusitis.
Pine Oil into homemade candles or wax melts to create a cozy and aromatic ambiance in living space.
Pine Oil can help control odor and provide a forest-fresh scent.

The aroma of Pine Oil is believed to have stress-relieving and calming effects.
Diffusing Pine Oil in the home or workplace can create a soothing atmosphere.
Pine Oil can be used as a natural insect repellent.

Pine Oil can be added to homemade repellent sprays or diffused to deter insects.
Pine Oil blends well with other essential oils.
Pine Oil can be combined with citrus oils, cedarwood, or spices to create seasonal and festive aromas.

Adding Pine Oil to water in a sauna or steam room can enhance the experience with its invigorating scent.
Mixing Pine Oil with water in a spray bottle creates a natural room freshener that can be used to eliminate odors and add a pleasant fragrance to the air.
Some food-grade Pine Oils may be used sparingly as a flavoring agent in culinary applications.

Pine Oil's important to ensure the oil is safe for internal use.
Pine Oil can be added to homemade wood polish for cleaning and revitalizing wooden furniture.
Blend Pine Oil with carrier oils like jojoba or sweet almond oil to create a natural and personalized pine-scented cologne or perfume.

Place a few drops of Pine Oil on a cotton ball or a wooden clothespin and clip it to the car's air vent for a natural car air freshener.
Add Pine Oil to DIY bath bomb recipes for a spa-like experience with the invigorating scent of pine during bath time.
Create a sleep sachet by filling a small pouch with dried lavender, chamomile, and a few drops of Pine Oil.

Place Pine Oil near pillow for a calming bedtime aroma.
Mix Pine Oil with castile soap and water to create a natural floor cleaner.
Use Pine Oil in DIY crafts, such as scented pinecone ornaments or handmade holiday decorations, to add a festive touch.
Pine Oil is used in aromatherapy applications, Pine Oil positively impacts the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.

Pine Oil is used to relieve mental, physical and sexual fatigue.
Also used to cleanse rooms, especially during time of change and illness.
Pine Oil is used in massage blends, the fortifying properties of Pine Needle Essential Oil eases every-day muscular aches and joint stiffness, and its detoxing qualities are
valuable in the battle against cellulite.

A strengthening and grounding Pine Oil, diffusing Pine Needle dispels negative emotions, and brings strength and comfort to sadness, burnout and stress.
Inhaling the scent of Pine Oil through diffusers or inhalers can promote a sense of alertness, clarity, and relaxation.

Pine Oil is often used in aromatherapy to uplift mood and reduce stress.
Pine Oil is known for its decongestant properties.

Safety Profile:
A flammable liquid when exposed to heat or flame; can react with oxidizing materials.
Pine Oil is used as an odorant, dtsinfectant, solvent, wetting agent, and frothing agent.
Moderately toxic by ingestion.

Pine Oil a weak allergen and a severe irritant to skin and mucous membranes.
Human systemic effects by ingestion: excitement, ataxia, headache.

Pine Oil liquid irritates skin.
If ingested, can irritate the entire digestive system and may injure kidneys.
If liquid is taken into lungs, causes severe pneumonitis,pulmonary edema/hemorrhage.



PINE OIL (TURPENTINE)
Pine oil (turpentine) is ideal for use in inhalations.
Pine oil (turpentine) has a positive, strengthening effect on both the mind and body.
Pine oil (turpentine) is refreshing and quickly clears the head.

CAS Number: 8002-09-3
EINECS Number: 692-006-0

Synonyms: 1093292-01-3,(1R,3Z)-3-(2,2-dimethylpropylidene)cyclohexan-1-ol;(1R,3E)-3-(2,2-dimethylpropylidene)cyclohexan-1-ol;(1S,3E)-3-(2,2-dimethylpropylidene)cyclohexan-1-ol Poly[N-(1-octylnonyl)-9H-carbazole-2,7-diyl], 2086312-08-3, 314270-00-3, 444619-08-3, 8002-09-3.

Pine oil (turpentine) has a strong piny odor and is miscible with alcohol.
Pine oil (turpentine) a complex combination of terpenes produced by the high temperature distillation of oil of turpentine residues or by the catalytic hydration of pinenes.
Composed primarily of isomeric tertiary and secondary cyclic terpene alcohols.

Pine oil (turpentine) has a high content of various alcohols.
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents.
They react with Pine oil (turpentine)s and carboxylic acids to form esters plus water.

Oxidizing agents convert them to aldehydes or ketones.
Pine oil (turpentine) is an aromatic oil derived from the needles of pine trees, primarily from the Pinus genus.
They may initiate the polymerization of isocyanates and epoxides.

Pine oil (turpentine) is a derivative of turpentine obtained by steam distillation of the species Pinus.
Pine oil (turpentine) has a strong piny odor and is miscible with alcohol.
Pine oil (turpentine) contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.

They have a relatively low human toxicity level.
They also have a low corrosion level and limited persistence.
Pine oil (turpentine) is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris.

Pine oil (turpentine) has fresh, bracing, antibacterial and stimulating properties.
Pine oil (turpentine) can help to ease muscle aches and pains and help improve circulation.

Pine oil (turpentine) is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris.
Pine oil (turpentine) has a strong piny odor and is miscible with alcohol.
Pine oil (turpentine) contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.

Pine oil (turpentine) has a supporting and energising effect that is used to relieve mental, physical and sexual fatigue.
Pine oil (turpentine) supports the respiratory system for clear and cool breathing, and warms and soothes stiff muscles and joints after everyday wear and tear.
As with other Pine oil (turpentine)s, pine has been used in traditional medicine for centuries.

Pine oil (turpentine) extracts are also abundant in everyday items.
These include floor and furniture cleaners, as well as disinfectants and air fresheners.
Pine oil (turpentine) extracts are not the same as essential oils because they don’t carry the same medicinal-strength properties.

Pine oil (turpentine)s contain multiple chemical compounds that make them so powerful.
Pine oil (turpentine)s a fresh and resinous fragrance that is reminiscent of forests and brings a sense of grounding and rejuvenation.
Pine oil (turpentine) is invigorating and cleansing scent is commonly used to create a refreshing and energizing atmosphere.

Pine oil (turpentine)s are highly concentrated, volatile aromatic substances that are obtained from various parts of plants.
They can be found in leaves, roots, flowers, seeds and even bark.
They add aroma to plants, protect them from danger, help them with pollination and are very rich in a lot of different effective and medical substances.

Pine oil (turpentine) extracts are often used in air fresheners for homes, offices, and vehicles.
Pine oil (turpentine)s, on the other hand, may be used in aromatherapy to create an uplifting and invigorating atmosphere — not just a nice scent.
Pine oil (turpentine) needle has a forest fragrance and is thus mentally refreshing.

Pine oil (turpentine) has energizing and mood-elevating properties, providing mental calmness with improved concentration and memory.
Pine oil (turpentine) is commonly used in households as a cleaner and a disinfectant.
Pine oil (turpentine) can improve circulation and reduce muscle and joint pain, and inflammation.

Pine oil (turpentine) is believed to be purifying, aids detoxification, and beneficial for dry and itchy skin.
Pine oil (turpentine) of pine needles is derived from the plant’s needle like leaves.
The leaves of pine trees are needle like to minimise transpiration and protect against snow.

Pine oil (turpentine) has a fresh forest smell with pleasant balsamic, sweet, spicy undertones.
Pine oil (turpentine) is known for its beneficial effects on muscles and joints and the respiratory system.
Pine oil (turpentine) has a distinctive and robust aroma that is often described as fresh, forest-like, and resinous.

Pine oil (turpentine) can evoke a sense of cleanliness and vitality.
The composition of Pine oil (turpentine) can vary depending on the species of pine.
Pine oil (turpentine) typically contains compounds such as alpha-pinene, beta-pinene, delta-3-carene, and others.

These compounds contribute to the Pine oil (turpentine)'s scent and therapeutic properties.
Pine oil (turpentine) is known for its antimicrobial properties, which may make it useful for cleaning and disinfecting purposes.
Pine oil (turpentine) is often used to help clear the respiratory system and ease symptoms of congestion and cough.

Pine oil (turpentine) may have anti-inflammatory effects, making it potentially beneficial for soothing minor skin irritations.
In aromatherapy, inhaling the scent of Pine oil (turpentine) is believed to be beneficial for respiratory health.
Pine oil (turpentine) may help open the airways and provide relief from congestion.

Due to its antimicrobial properties and refreshing scent, Pine oil (turpentine) is used in natural cleaning products.
Pine oil (turpentine) can be added to homemade cleaners to impart a pleasant fragrance and enhance the cleaning power.
Pine oil (turpentine) is often used in aromatherapy to create an uplifting and energizing atmosphere.

Pine oil (turpentine) may contribute to feelings of alertness and well-being.
Pine oil (turpentine) can be applied topically for massage, but it's important to use a carrier oil to prevent skin irritation.
Always perform a patch test before applying essential oils directly to the skin.

The fresh and clean scent of Pine oil (turpentine) makes it a popular choice for natural air fresheners and deodorizers.
Pine oil (turpentine) is not generally effective against non-enveloped viruses or spores.
Pine oil (turpentine) will kill the causative agents of typhoid, gastroenteritis, rabies, enteric fever, cholera, several forms of meningitis, whooping cough, gonorrhea and several types of dysentery.

Pine oil (turpentine) is also effective against several of the leading causes of food poisoning.
Pine oil (turpentine) is not effective against spore related illneses such as tetanus or anthrax or against non-enveloped viruses such as poliovirus, rhinovirus, hepatitis B or hepatitis C.
Pine oil (turpentine) has antiseptic and disinfectant properties and is a common ingredient in household cleaning products and air fresheners.

Pine oil (turpentine) is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris.
Pine oil (turpentine) has a strong piny odor and is miscible with alcohol.
Pine oil (turpentine) contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.

Pine oil (turpentine) is distilled from the needles of the Scots pine tree.
Known to mankind for centuries, Pine oil (turpentine) needle essential oil was used by the Romans and Ancient Greeks to treat muscular aches and pains.
Pine oil (turpentine) is clear in colour with a fresh forest scent with balsamic undertones.

Pine oil (turpentine) is a fantastic natural ingredient but needs to be used with a little caution.
Pine oil (turpentine)s can sensitise skin and shouldn't be applied to the skin directly or consumed.
Please consult a doctor before use if pregnant and always keep out of reach of children.

Pine oil (turpentine)s are increasingly gaining mainstream popularity as possible alternatives to medications.
These plant-derived ingredients are still being studied for their medicinal effects, and Pine oil (turpentine) is no exception.
Pine oil (turpentine) is a derivative of pine tree needles, which are known for their strong aroma.

In fact, one sniff of Pine oil (turpentine) might remind you of a Christmas tree.
Pine oil (turpentine) is mainly applied in the production of household detergent, industrial cleaner, high quality ink and paint solvent owing to its pleasant pine smell, notable antimicrobial power and excellent solvency, low concentration ones can be used as foaming agent in ore floatation.
Pine oil (turpentine) is a phenolic disinfectant.

Pine oil (turpentine) is generally effective against numerous bacterial strains and enveloped viruses.
Pine oil (turpentine) disinfectants are relatively inexpensive and widely available.
Pine oil (turpentine) a large addition of white pine needles to spruce needles tends to lower considerably the ester content of the distilled spruce oil.

May contain terpene hydrocarbons and ethers.
Exact composition varies with production methods and turpentine source.
Contains mainly tertiary and secondary terpene alcohols Produced from the wood of pine trees by extraction or steam distillation.

There are various species of pine trees, and their needles are steam-distilled to extract the Pine oil (turpentine).
Pine oil (turpentine) contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons.

Pine oil (turpentine) is derived from the needles of the Pine Tree, commonly recognized as the traditional Christmas tree.
Alcohols exhibit both weak acid and weak base behavior.

Pine oil (turpentine) has a fresh, woody, and invigorating aroma reminiscent of the outdoors.
Pine oil (turpentine) a clear colorless to light amber colored liquid.
Pine oil (turpentine) less dense than water and insoluble in water.

The production of essential oil from Pine oil (turpentine) has been abandoned.
The needles are probably distilled with those from spruce.
Extractives and their physically modified derivatives.

Melting point: −55 °C(lit.)
Boiling point: 153-175 °C(lit.)
Density: 0.86 g/mL at 25 °C(lit.)
vapor density: 4.84 (−7 °C, vs air)
vapor pressure: 4 mm Hg ( −6.7 °C)
refractive index: n20/D 1.515
Flash point: 86 °F
Odor: at 100.00 %. pine

Pine oil (turpentine) is fresh and uplifting aroma is commonly used in seasonal blends and festive aromatherapy.
Some people believe that the inhalation of Pine oil (turpentine) may have positive effects on cognitive function, including improved focus and mental clarity.
Pine oil (turpentine) is commonly used in sauna aromatherapy.

Adding a few drops to water in a sauna can enhance the experience with its invigorating scent.
Pine forests are known for their distinctive scent.
Pine oil (turpentine) can be used recreationally or therapeutically to simulate the experience of being in a pine forest, a practice known as "forest bathing" or shinrin-yoku.

The aroma of Pine oil (turpentine) is often associated with feelings of freshness and vitality.
In aromatherapy, Pine oil (turpentine) is sometimes used to provide emotional support and a sense of well-being.
Due to its cleansing properties, Pine oil (turpentine) can be added to homemade all-purpose cleaners.

Pine oil (turpentine) not only contributes to the cleaning power but also imparts a pleasant scent.
Pine oil (turpentine) can be added to a homemade furniture revitalizer or polish to restore and refresh the appearance of wooden furniture.

Pine oil (turpentine) is a popular choice for making DIY candles.
Pine oil (turpentine) is fragrance can create a cozy and comforting atmosphere, especially during the colder months.
Inhaling the aroma of Pine oil (turpentine) is thought by some to have mood-lifting properties, helping to alleviate feelings of fatigue or low energy.

Adding a few drops of Pine oil (turpentine) to a warm bath can create a spa-like experience and contribute to a sense of relaxation.
Portable inhalers and electric diffusers can be used to enjoy the benefits of Pine oil (turpentine) aromatherapy on the go or in different rooms of the home.
Experiment with creating seasonal blends by combining Pine oil (turpentine) with other seasonal scents like citrus, cinnamon, or clove for a festive atmosphere.

Pine oil (turpentine) has a refreshing sweet-resinous woody aroma and it is said to have a cleansing and invigorating effect.
Pine oil (turpentine) can help combat fatigue, stimulate circulation and can be used in massage blends for sore aching muscles.
Pine oil (turpentine) is effective in the treatment of respiratory complaints eg. colds, flu, sinusitis and bronchitis and is also used in saunas and steam rooms.

Pine oil (turpentine) is great for vapour therapy in a sick room as it promotes healing.
Pine oil (turpentine) can cause allergic reactions, it is very useful to relieve mental, physical and sexual fatigue, while having a cleansing and clearing effect on a room.
Even though Pine oil (turpentine) can be used in cystitis, hepatitis and prostate problems, as well as to improve circulation and to relieve rheumatism, gout, sciatica and arthritis, it should be done so with care due to the sensitizing nature of this oil.

Pine oil (turpentine) has a fresh forest smell, is pale yellow in colour and watery in viscosity.
Significant in many early systems of medicine, pine needle essential oil has been used for hundreds of years to protect against illness and infection.
A natural air freshener, Pine oil (turpentine) can help to protect our health when diffused and can also act as a natural perfume or deodorant to help mask personal odour.

Pine oil (turpentine)'s soothing, cleansing effects make it a popular skin tonic, able to clear up imperfections and calm irritations.
Pine oil (turpentine) is also a great choice for use in home cleaning sprays due to its powerful antibacterial activity and its refreshing scent.
Pine oil (turpentine) is commonly recognized as the traditional Christmas Tree.

Pine oil (turpentine) is clarifying and uplifting oil offers numerous health benefits and it is notable for its strong woody scent.
Pine oil (turpentine) is commonly used to cleanse, ease and energize the body and mind.
The sweet, fresh and green aroma of Pine oil (turpentine) is unmistakable, and diffusing it around the home is like taking a walk in a coniferous forest - uplifting, refreshing and highly invigorating.

Pine oil (turpentine) has a long history of use in folk medicine, and with good reason.
Pine oil (turpentine) stimulates the body’s metabolic rate and energises all body systems, making it good for convalescence as well as boosting the emotions.
Pine oil (turpentine) is derived from the needles of the Pine Tree. The scent has a clarifying, uplifting, and invigorating effect, often used in aromatherapy applications.

Pine oil (turpentine)’s reputed to assist with skin related problems such as soothing itchiness, inflammation, control excessive perspiration, protect minor abrasions from developing infections and slowing the appearance of ageing.
The invigorating and grounding aroma of Pine oil (turpentine) is believed to have stress-relieving properties.
Diffusing the Pine oil (turpentine) or inhaling its scent may help promote relaxation and reduce feelings of stress and anxiety.

Pine oil (turpentine) is sometimes used topically in diluted form for massage to support joint and muscle health. ,
Pine oil (turpentine) is anti-inflammatory properties may provide relief from minor aches and pains.
Adding a few drops of Pine oil (turpentine) to hair care products or creating a DIY hair treatment may contribute to a healthy scalp and hair.

Pine oil (turpentine) is refreshing scent is an additional benefit in hair care formulations.
The aroma of Pine oil (turpentine) is known to be unpleasant to certain insects.
Pine oil (turpentine) can be used in natural insect repellent formulations or added to homemade candles and diffusers to help deter insects.

In aromatherapy and meditation, the earthy and grounding aroma of Pine oil (turpentine) is thought to promote a sense of stability and centering.
Pine oil (turpentine) can be used alone or in blends for these purposes.
Pine oil (turpentine) can be added to homemade room sprays and linen spritzers to impart a fresh and clean scent to living spaces and fabrics.

Pine oil (turpentine) can be incorporated into DIY personal care products, such as soaps, lotions, and bath salts, to provide a natural and uplifting fragrance.
Due to its natural woodsy aroma, Pine oil (turpentine) can be added to homemade wood polish to clean and shine wooden furniture.
Some varieties of Pine oil (turpentine), labeled as safe for internal use and meeting food-grade standards, can be used sparingly as a flavoring agent in culinary applications.

However, Pine oil (turpentine)'s crucial to ensure that the oil is specifically designated for consumption.
In educational or therapeutic settings, the scent of Pine oil (turpentine) is sometimes used to create a focused and refreshing atmosphere.

Pine oil (turpentine)'s antimicrobial properties make it a natural disinfectant.
Pine oil (turpentine) can be added to cleaning solutions to help sanitize surfaces in the home.

Pine oil (turpentine) is known for its decongestant properties.
Inhaling its vapors may help open nasal passages and relieve respiratory congestion.
Pine oil (turpentine) can be used in steam inhalation or in a diffuser during cold and flu seasons.

Some varieties of Pine oil (turpentine), labeled as food-grade, can be used in minimal amounts for flavoring certain dishes.
Pine oil (turpentine)'s crucial to ensure the oil is safe for internal use, and only a tiny amount should be used due to its concentrated nature.
Add a few drops of Pine oil (turpentine) to a basin of warm water for a refreshing foot soak.

This can be both relaxing and invigorating, and the oil may contribute to foot health.
Create a DIY room spray by combining Pine oil (turpentine) with other essential oils known for their focus-enhancing properties, such as peppermint or rosemary.
Pine oil (turpentine) use this spray in workspaces or study areas.

Pine oil (turpentine) can be added to potpourri or used in sachets to bring the fresh and outdoorsy scent indoors.
This is a natural way to freshen up living spaces.
Bring a portable diffuser or a cloth with a few drops of Pine oil (turpentine) on outdoor activities like camping or hiking.

The scent can add to the experience and repel insects.
Create a natural room freshener by combining Pine oil (turpentine) with water in a spray bottle.
Use Pine oil (turpentine) to freshen the air in home without synthetic fragrances.

Place cotton balls or pieces of fabric scented with Pine oil (turpentine) in drawers and closets to keep clothes smelling fresh and to deter pests.
Make pine-scented candles by adding Pine oil (turpentine) to melted candle wax.
This can be a delightful way to enjoy the aroma of pine indoors.

Mix Pine oil (turpentine) with Epsom salts to create pine-infused bath salts.
Add a handful to your bath for a soothing and aromatic experience.

Create DIY air freshener disks by combining baking soda with Pine oil (turpentine).
The scent of Pine oil (turpentine) is often associated with winter and the holiday season.

Uses:
Pine oil (turpentine) is used in massage applications, Pine oil (turpentine) is known to soothe inflammation, soreness, aches, pain, and gout; to stimulate and enhance circulation; to facilitate the healing of scratches, cuts, wounds, and burns; to promote the regeneration of new skin; to reduce pain; to relieve muscle fatigue; to promote the body’s detoxification; to maintain the health and function of the urinary tract and the kidneys; and to regulate body weight.
Pine oil (turpentine) is originally used as a solvent and a disinfectant, it is also deodorizing, anti-bacterial and anti-septic.

Studies are now showing that certain fractions of Pine oil (turpentine) may stimulate fibroblast growth, which would mean an increase in the turnover of epidermal cells.
Pine oil (turpentine) is produced by distillation of small pine branches.
Combine with dried pinecones, citrus peels, and spices for a seasonal mix.

Create natural reed diffusers by combining Pine oil (turpentine) with a carrier oil (such as sweet almond oil) and placing reed sticks in the mixture.
This provides a continuous release of the pine fragrance in a room.

Infuse pinecones with the scent of Pine oil (turpentine) by placing them in a bag with a few drops of oil.
Let them sit for some time before using them as decorative or aromatic elements in your home.
Make homemade playdough and add a few drops of Pine oil (turpentine) for a delightful sensory experience, especially for children.

Create sachets filled with dried herbs, flowers, or cedar chips infused with Pine oil (turpentine).
Place these sachets in drawers or closets for a natural and pleasant scent.
Combine Pine oil (turpentine) with a carrier oil or wood polish to revitalize wooden furniture, leaving it with a fresh and polished appearance.

Add a few drops of Pine oil (turpentine) to a damp cloth or a dryer ball and toss it into the dryer with your laundry for a natural and refreshing fragrance.
Mix Pine oil (turpentine) with baking soda and sprinkle it on carpets before vacuuming.
This acts as a natural carpet freshener, eliminating odors and leaving a pleasant scent.

Create cleaning wipes by adding Pine oil (turpentine) to a solution of water, vinegar, and a small amount of liquid soap.
Use these wipes for cleaning surfaces around the home.
Bring Pine oil (turpentine) on camping trips for a touch of the outdoors.

Diffuse Pine oil (turpentine) or apply diluted oil to the skin to repel insects naturally.
Pine oil (turpentine) with water and use it as a natural pet odor neutralizer.
Spray Pine oil (turpentine) in pet bedding or areas where odors may be present.

Create wax sachets infused with Pine oil (turpentine) by melting a mixture of beeswax and coconut oil.
Pour the melted wax into molds, add Pine oil (turpentine), and let it solidify.
Pine oil (turpentine) is used in the following products: washing & cleaning products, air care products, biocides (e.g. disinfectants, pest control products) and polishes and waxes.

Other release to the environment of Pine oil (turpentine) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Other release to the environment of Pine oil (turpentine) is likely to occur from: indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and leather (e.g. gloves, shoes, purses, furniture).

Pine oil (turpentine) is used in the following products: air care products, coating products, polishes and waxes, washing & cleaning products, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), laboratory chemicals, leather treatment products, paper chemicals and dyes, perfumes and fragrances, pharmaceuticals and textile treatment products and dyes.
Pine oil (turpentine) is used in the following areas: health services.
Pine oil (turpentine) is used for the manufacture of: textile, leather or fur, pulp, paper and paper products and machinery and vehicles.

Other release to the environment of Pine oil (turpentine) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Pine oil (turpentine) can also be used for cuts and sores, scabies and lice and for excessive perspiration, while its warming properties help with rheumatism, arthritis, gout, muscular aches and pains and it can stimulate circulation.
Furthermore Pine oil (turpentine) can help in cases of bronchitis, asthma, catarrh, coughs, laryngitis, colds and flu.

Pine oil (turpentine) eases breathlessness and sinusitis.
Pine oil (turpentine) into homemade candles or wax melts to create a cozy and aromatic ambiance in living space.
Pine oil (turpentine) can help control odor and provide a forest-fresh scent.

The aroma of Pine oil (turpentine) is believed to have stress-relieving and calming effects.
Diffusing Pine oil (turpentine) in the home or workplace can create a soothing atmosphere.
Pine oil (turpentine) can be used as a natural insect repellent.

Pine oil (turpentine) can be added to homemade repellent sprays or diffused to deter insects.
Pine oil (turpentine) blends well with other essential oils.
Pine oil (turpentine) can be combined with citrus oils, cedarwood, or spices to create seasonal and festive aromas.

Adding Pine oil (turpentine) to water in a sauna or steam room can enhance the experience with its invigorating scent.
Mixing Pine oil (turpentine) with water in a spray bottle creates a natural room freshener that can be used to eliminate odors and add a pleasant fragrance to the air.
Some food-grade Pine oil (turpentine)s may be used sparingly as a flavoring agent in culinary applications.

Pine oil (turpentine)'s important to ensure the oil is safe for internal use.
Pine oil (turpentine) can be added to homemade wood polish for cleaning and revitalizing wooden furniture.
Blend Pine oil (turpentine) with carrier oils like jojoba or sweet almond oil to create a natural and personalized pine-scented cologne or perfume.

Place a few drops of Pine oil (turpentine) on a cotton ball or a wooden clothespin and clip it to the car's air vent for a natural car air freshener.
Add Pine oil (turpentine) to DIY bath bomb recipes for a spa-like experience with the invigorating scent of pine during bath time.
Create a sleep sachet by filling a small pouch with dried lavender, chamomile, and a few drops of Pine oil (turpentine).

Place Pine oil (turpentine) near pillow for a calming bedtime aroma.
Mix Pine oil (turpentine) with castile soap and water to create a natural floor cleaner.
Use Pine oil (turpentine) in DIY crafts, such as scented pinecone ornaments or handmade holiday decorations, to add a festive touch.
Pine oil (turpentine) is used in aromatherapy applications, Pine oil (turpentine) positively impacts the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook.

Pine oil (turpentine) is used to relieve mental, physical and sexual fatigue.
Also used to cleanse rooms, especially during time of change and illness.
Pine oil (turpentine) is used in massage blends, the fortifying properties of Pine Needle Essential Oil eases every-day muscular aches and joint stiffness, and its detoxing qualities are
valuable in the battle against cellulite.

A strengthening and grounding Pine oil (turpentine), diffusing Pine Needle dispels negative emotions, and brings strength and comfort to sadness, burnout and stress.
Inhaling the scent of Pine oil (turpentine) through diffusers or inhalers can promote a sense of alertness, clarity, and relaxation.
Pine oil (turpentine) is often used in aromatherapy to uplift mood and reduce stress.

Pine oil (turpentine) is known for its decongestant properties.
Pine oil (turpentine) may be irritating to the skin and mucous membranes.
Add Pine oil (turpentine) to homemade potpourri blends for a natural and long-lasting fragrance.

Pine oil (turpentine) can be added to homemade cleaners to disinfect surfaces and leave a clean fragrance.
When diluted with a Pine oil (turpentine), Pine oil (turpentine) can be applied topically for massages.
Pine oil (turpentine) is anti-inflammatory properties may help soothe sore muscles and joints.

Pine oil (turpentine) is used in the formulation of perfumes, colognes, and other personal care products for its fresh and woody fragrance.
Adding a few drops of Pine oil (turpentine) to a foot soak or foot cream can contribute to foot health and provide a refreshing sensation.
Pine oil (turpentine) can be incorporated into DIY soaps, lotions, and skincare products for its pleasant scent and potential skin-soothing properties.

Pine oil (turpentine)'s antibacterial properties make it a suitable ingredient for natural deodorants.
Use Pine oil (turpentine) on hardwood or tile floors for a fresh and clean scent.
Make wax melts by melting soy wax and adding Pine oil (turpentine).

Place them in a wax warmer for a long-lasting pine fragrance.
Add a few drops of Pine oil (turpentine) to liquid hand soap to enjoy the refreshing scent each time wash hands.
Infuse a pine garland with Pine oil (turpentine) for a fragrant and decorative touch during the holiday season.

Create a linen spray by mixing Pine oil (turpentine) with water and a small amount of vodka or witch hazel. Spritz it on linens for a fresh scent.
Pine oil (turpentine) is used topically, Pine oil (turpentine) is reputed to soothe itchiness, inflammation, and dryness, control excessive perspiration, prevent fungal infections, protect minor abrasions from developing infections, slow the appearance of signs of aging, and enhance circulation.
Pine oil (turpentine) is used medicinally, Pine oil (turpentine) is reputed to support immune function, clear the respiratory tract, address symptoms of colds, coughs, sinusitis, asthma, and the flu, and facilitate the healing of infections.

Safety Profile:
Pine oil (turpentine) a weak allergen and a severe irritant to skin and mucous membranes.
Human systemic effects by ingestion: excitement, ataxia, headache.
Pine oil (turpentine) liquid irritates skin.

If ingested, can irritate the entire digestive system and may injure kidneys.
If liquid is taken into lungs, causes severe pneumonitis,pulmonary edema/hemorrhage.
A flammable liquid when exposed to heat or flame; can react with oxidizing materials.

Pine oil (turpentine) is used as an odorant, dtsinfectant, solvent, wetting agent, and frothing agent.
Moderately toxic by ingestion.

PINE OIL 85%
Pine Oil 85% Pine oil 85% is an essential oil obtained by the steam distillation of stumps,[2] needles, twigs and cones[3] from a variety of species of pine, particularly Pinus sylvestris. As of 1995, synthetic Pine oil 85% was the "biggest single turpentine derivative."[4] Synthetic Pine oil 85%s accounted for 90% of sales as of 2000. In alternative medicine, it is said to be used in aromatherapy, as a scent in bath oils or more commonly as a cleaning product, and as a lubricant in small and expensive clockwork instruments. It may also be used varyingly as a disinfectant, sanitizer, microbicide (or microbistat), virucide or insecticide.[6] It is also used as an effective herbicide where its action is to modify the waxy cuticle of plants, resulting in desiccation.[7] Pine oil 85% is distinguished from other products from pine, such as turpentine, the low-boiling fraction from the distillation of pine sap, and rosin, the thick tar remaining after turpentine is distilled. Chemically, Pine oil 85% consists mainly of α-terpineol and other cyclic terpene alcohols.[1] It may also contain terpene hydrocarbons, ethers, and esters. The exact composition depends on various factors, such as the variety of pine from which it is produced and the parts of the tree used. Properties as a disinfectant Pine oil 85% is a disinfectant that is mildly antiseptic.[8] It is effective against Brevibacterium ammoniagenes, the fungi Candida albicans, Enterobacter aerogenes, Escherichia coli, Gram-negative enteric bacteria, household germs, Gram-negative household germs such as those causing salmonellosis, herpes simplex types 1 and 2, influenza type A, influenza virus type A/Brazil, influenza virus type A2/Japan, intestinal bacteria, Klebsiella pneumoniae, odor-causing bacteria, mold, mildew, Pseudomonas aeruginosa, Salmonella choleraesuis, Salmonella typhi, Salmonella typhosa, Serratia marcescens, Shigella sonnei, Staphylococcus aureus, Streptococcus faecalis, Streptococcus pyogenes, and Trichophyton mentagrophytes.[6] It will kill the causative agents of typhoid, gastroenteritis (some agents), rabies, cholera, several forms of meningitis, whooping cough, gonorrhea and several types of dysentery.[9] It is not effective against spore related illnesses, such as tetanus or anthrax, or against non-enveloped viruses such as poliovirus, rhinovirus, hepatitis B, or hepatitis C.[9] Froth flotation Industrially, Pine oil 85% is used as a frother in mineral extraction from ores.[1] For example, in copper extraction Pine oil 85% is used to condition copper sulfide ores for froth flotation. Therefore, it is important in the industry for the froth flotation process. It has largely been replaced by synthetic alcohols and polyglycol ethers. Safety Pine oil 85% has a relatively low human toxicity level, a low corrosion level and limited persistence; however, it irritates the skin and mucous membranes and has been known to cause breathing problems.[8][10] Large doses may cause central nervous system depression. What You Need to Know About Pine oil 85% Essential oils are increasingly gaining mainstream popularity as possible alternatives to medications. These plant-derived ingredients are still being studied for their medicinal effects, and Pine oil 85% is no exception. Made from pine trees, Pine oil 85% offers numerous purported health benefits and is notable for its strong woody scent. While pine tree oil may offer some benefits, there’s also possible side effects to consider, just like with any other type of essential oil. Learn the pros and cons so that you can best decide whether pine tree essential oil is worth trying. What is Pine oil 85%? Pine oil 85% is a derivative of pine tree needles, which are known for their strong aroma. In fact, one sniff of Pine oil 85% might remind you of a Christmas tree. As with other essential oils, pine has been used in traditional medicine for centuries. Pine scents and oil extracts are also abundant in everyday items. These include floor and furniture cleaners, as well as disinfectants and air fresheners. However, oil extracts are not the same as essential oils because they don’t carry the same medicinal-strength properties. Essential oils contain multiple chemical compounds that make them so powerful. As such, essential oils shouldn’t be ingested. Pine oil 85% uses and benefits Due to its aroma, Pine oil 85% is notable for its uplifting yet clearing scent. Because of this, Pine oil 85% can work as a room scent in a diffuser as well as in cleaning solutions. The internet is full of anecdotes and articles that claim Pine oil 85% can offer more health benefits than just a nice scent. However, most of these claims lack clinical evidence. Air fresheners and aromatherapy Pine oil 85% extracts are often used in air fresheners for homes, offices, and vehicles. Essential oils, on the other hand, may be used in aromatherapy to create an uplifting and invigorating atmosphere — not just a nice scent Inhaling oils like pine may also have clearing effects in the case of illnesses like the common cold. Skin antimicrobial Some proponents claim that Pine oil 85% may be used topically (applied to the skin) as an antimicrobial, similar to tea tree oil. In theory, the oil could be used for minor skin infections and burns. However, research indicates that Pine oil 85% doesn’t have much antimicrobial activity. Talk to a doctor before using Pine oil 85% for this purpose. Reduced inflammation Pine oil 85% is also touted as having anti-inflammatory effects. In theory, such effects could do two things: Ease symptoms of inflammatory skin conditions, such as acne, eczema, and rosacea. Alleviate pain from related health conditions, such as arthritis and muscle pain. However, more research is needed on this front. Other essential oils have in fact been shown to have anti-inflammatory properties. These include: turmeric; ginger; frankincense; peppermint Odor: fresh, sweet-resinous, woody, turpentine, coniferous, balsamic Pine oil 85%'s production and use as a flavoring and in perfumery may result in its release to the environment through various waste streams. Pine oil 85% is a component of essential oils. If released to air, an estimated vapor pressure of 3.3X10-2 mm Hg at 25 °C indicates Pine oil 85% will exist solely as a vapor in the atmosphere. Vapor-phase Pine oil 85% will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2 hrs. Pine oil 85% does contain chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight. If released to soil, Pine oil 85% is expected to have slight mobility based upon an estimated Koc of 3,700. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 2.4X10-3 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. Biodegradation data were not available. If released into water, Pine oil 85% is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 7.4 hrs and 6.5 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 30 days if adsorption is considered. An estimated BCF of 260 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is expected based on estimated second order hydrolysis half-lives of 231 and 23 days at pH values of 7 and 8, respectively. Occupational exposure to Pine oil 85% may occur through inhalation and dermal contact with this compound at workplaces where Pine oil 85% is produced or used. Monitoring data indicate that the general population may be exposed to Pine oil 85% via inhalation, ingestion of food, and dermal contact with this compound and other consumer products containing Pine oil 85%. Side effects of Pine oil 85% When used in aromatherapy, essential oils can have effects on those who inhale them. However, some essential oils are toxic to pets or dangerous for pregnant women and children. It’s also possible to have skin reactions to these oils, including Pine oil 85%. Possible side effects include: redness; hives; itchiness; dry skin; swelling; peeling skin If you are allergic to pine trees, don’t use Pine oil 85%. While not considered common, some people are allergic to pine pollen. You might be allergic to Pine oil 85% if you develop allergy-like symptoms, such as sneezing or skin rashes. How to use Pine oil 85% Pine oil 85% can be used in a number of different ways, including inhalation and topical variations. Talk to a doctor about the following methods. Use a diffuser Diffusing is one of the most popular ways to use essential oils. You can make a quick, safe room scent by putting a few drops of Pine oil 85% into a diffuser filled with water. Once the device is turned on, the diffuser then releases cool steam. You can purchase a diffuser online. Inhale it If you don’t have a diffuser on hand, you may still reap the aromatic benefits of Pine oil 85% through inhalation. Simply pour a couple of drops on a tissue, and hold the tissue in front of your face while you inhale deeply through your nose. You can also try holding the bottle of essential oil underneath your nose. Apply it topically Pine oil 85% may be used topically, either through direct application or via a massage. It’s important to dilute Pine oil 85% with a carrier oil before applying directly to your skin. Add a tablespoon of almond, jojoba, or coconut oil to a few drops of Pine oil 85%. You can also use this combination for a patch test 24 hours beforehand to make sure you’re not sensitive to pine. Add some to your bath Essential oils can also be used in the bath. Add several drops of the essential oil to warm running water. Watch for slippery surfaces as you get in and out of the tub. Precautions Essential oils like pine are appealing because of their “natural” allure. However, these plant derivatives are powerful enough to mimic the effects of conventional medicine. This is why it’s always a good idea to talk to a doctor before using them, especially if you’re pregnant or have any preexisting health condition. The best way to reduce the risk of side effects is to take safety precautions before using Pine oil 85%: Don’t use essential oils near your eyes. Make sure to combine your essential oils with a carrier oil. Never take essential oils by mouth. Where to get Pine oil 85% Due to the popularity of essential oils, you can find Pine oil 85% in natural health stores, drugstores, and massage clinics. You can also choose from a variety of Pine oil 85% products online. The takeaway While you might know pine for its scent, a lot of medicinal claims are being made about its essential oil. Diffusing Pine oil 85% probably won’t cause any harm, but you should talk to your doctor before using it for any medical purpose. Stop using the oil right away if you experience symptoms of an allergic reaction. Pine oil 85%, essential oil consisting of a colourless to light amber liquid of characteristic odour obtained from pine trees, or a synthetic oil similar in aroma and other properties. Pine oil 85% is used as a solvent for gums, resins, and other substances. It has germicidal properties and is employed medically as a principal constituent of general disinfectants. It is also used in odorants, insecticides, detergents, wetting and emulsifying agents, wax preparations, and antifoaming agents and in textile scouring and the flotation process for refining lead and zinc ores. Pitch-soaked wood of the pine tree, principally Pinus palustris but also certain other species of the family Pinaceae, is subjected to steam distillation, solvent extraction followed by steam distillation, or destructive distillation to obtain the Pine oil 85%, which boils at 200°–220° C (390°–430° F). A variety of similar Pine oil 85% is obtained by distillation of cones and needles of various species of pines or by extraction from the stumps using solvents and steam. Synthetic Pine oil 85% is produced by conversion of terpene hydrocarbons into terpene alcohols. Chemically, Pine oil 85%s consist principally of cyclic terpene alcohols and are used in the manufacture of chemicals. Pine oil 85% is insoluble in water but dissolves in alcohol and other organic solvents. Pine oil has a fresh, woodsy aroma that is refreshing and empowering. When diffused it can help to ground and uplift mood and encourage feelings of positive energy. Pine oil 85%s are directly irritating to mucous membranes, producing erythema of the oropharynx, mouth, and skin. Pine oil 85%s and Turpentine Pine oil 85%s, derived by steam distillation of wood from pines, consist of a mixture of terpene alcohols. Pine oil 85%–based compounds may contain small amounts of phenol derivatives. The concentration of Pine oil 85% in disinfectant cleaners varies from 0.3% to 60%.18 Many “Pine oil 85%” cleaners marketed in the United States are pine scented but contain little or no actual Pine oil 85%, so it is important to check the label on pine-scented cleaners. Pine Sol, one of the most widely used Pine oil 85% cleaners, contains 8% to 12% Pine oil 85%, 3% to 7% alkyl alcohol ethoxylates, 1% to 5% isopropanol, and 1% to 5% sodium petroleum sulfonate in its “Original” formulation19; other cleaners branded as Pine Sol contain no Pine oil 85%. Turpentine is a hydrocarbon mixture of terpenes derived from Pine oil 85% rather than petroleum and is often applied as a paint thinner. The oral LD50 of Pine oil 85% ranges from 1 to 2.7 mL/kg BW. A substantially lower dose results in severe toxicosis.2 Pine oil 85% is readily absorbed from the gastrointestinal tract and is metabolized by the liver to be excreted in urine as glucuronide conjugates. High concentrations of ingested Pine oil 85% are demonstrable in lung tissue, lending a characteristic pine or turpentine odor to the breath.18 As is true for phenolic compounds, cats are more susceptible than other species to Pine oil 85% toxicoses.20 Pine oil 85%s are directly irritating to mucous membranes, producing erythema of the oropharynx, mouth, and skin. Ocular exposure causes marked blepharospasm, epiphora, photosensitivity, and erythema of the conjunctiva and sclera.2 Ingestion results in nausea, hypersalivation, bloody vomiting, and abdominal pain. Systemic effects include weakness and CNS depression, ataxia, hypotension, and respiratory depression. Pulmonary toxicity is due to aspiration during ingestion or from emesis or may be due to chemical pneumonitis from absorption of the Pine oil 85% through the gastrointestinal tract with subsequent deposition in the lung.18 Myoglobinuria and acute renal failure may develop following massive ingestions. A cat that ingested 100 mL of undiluted Pine Sol had severe depression, ataxia, unresponsive pupils, and shock, and died within 12 hours. Pulmonary edema, acute centrilobular hepatic necrosis, and total renal cortical necrosis were present at necropsy examination. Prompt dilution with milk, egg white, or water should occur following ingestion of Pine oil 85% disinfectants. Because of rapid onset of depression and the danger of aspiration pneumonia, emesis is often contraindicated, and even gastric lavage with placement of a cuffed endotracheal tube poses risk. Dilution should be followed by the administration of activated charcoal and a saline or osmotic cathartic. Symptomatic and supportive care, consisting of maintenance of renal perfusion and acid-base and electrolyte balance, is crucial. Animals that have their dermis exposed should be bathed with soap and then rinsed with copious amounts of water as soon as feasible after the exposure. One of the other advantages of Pine oil 85% in an all purpose cleaner is that it can also function as a disinfecting ingredient, although it is not very broad spectrum (effective primarily against Gram-negative bacteria) and requires fairly high concentrations as compared to other disinfectants. Pine oil 85% acts as a dual purpose ingredient, participating in both cleaning and disinfecting. This is in contrast to quaternary ammonium surfactants, “quats” that do not participate in cleaning and can actually hamper it by interacting with anionic surfactants. Pine oil 85% consists of complex mixtures of monoterpene hydrocarbons (alpha, beta-pinene) and oxygenated monoterpenes (terpineol, borneol, bornyl acetate) [28]. Compared to other disinfectants, antimicrobial activity is relatively low. Concentrated formulations may contain over 50% Pine oil 85% with soap/anionic surfactant and alcohol to provide a blooming effect when diluted in water. End use concentrations of more than 0.5% are often required for disinfection. Quaternary ammonium compounds or phenolics may be combined with reduced levels of Pine oil 85% to improve disinfectant activity while retaining the characteristic pine scent. Pine oil 85% Disinfectants Toxicokinetics Pine oil 85% is readily absorbed from the gastrointestinal tract and metabolized, with glucuronide conjugation, in the liver. Inhalation, or systemic distribution, of absorbed Pine oil 85% to the lungs may cause chemical pneumonitis. Conjugates are excreted in the urine, although if a large amount has been ingested, there may be a pine or turpentine odor to the breath. The LD50 of Pine oil 85% is in the range 1–2.5 mL/kg BW. Cats, because of their limited capacity for glucuronidation, are particularly susceptible to toxicosis. Mode(s) of Action Pine oil 85% is directly irritating to mucous membranes, and is also a central nervous system (CNS) and respiratory depressant. Public Health Considerations Pine oil 85% poses the same risk to human beings, especially preschool children, as it does to domestic pets. Prevention Pine oil 85% and Pine oil 85%-based compounds should be stored out of reach of small children or pets, and used in accordance with the manufacturer’s directions. Pine oil 85% is an essential oil obtained by the steam distillation of needles, twigs and comes from a variety of species of pine, particularly Pinus sylvestris. It has a strong piny odor and is miscible with alcohol. Pine oil 85% contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons. Use: Pine oil 85% is a derivative of turpentine obtained by steam distillation of the species Pinus. Pine oil 85% has a strong piny odor and is miscible with alcohol. Pine oil 85% contains alpha-terpineol plus other cyclic terpene alcohols and terpene hydrocarbons. Pine oil 85% is mainly applied in the production of household detergent, industrial cleaner, high quality ink and paint solvent owing to its pleasant pine smell, notable antimicrobial power and excellent solvency, low concentration ones can be used as foaming agent in ore floatation. Pine oil 85% is a phenolic disinfectant. It is generally effective against numerous bacterial strains and enveloped viruses. Pine oil 85% is not generally effective against non-enveloped viruses or spores. Pine oil 85% will kill the causative agents of typhoid, gastroenteritis, rabies, enteric fever, cholera, several forms of meningitis, whooping cough, gonorrhea and several types of dysentery. Pine oil 85% is also effective against several of the leading causes of food poisoning. Pine oil 85% is not effective against spore related illneses such as tetanus or anthrax or against non-enveloped viruses such as poliovirus, rhinovirus, hepatitis B or hepatitis C. Pine oil 85% disinfectants are relatively inexpensive and widely available. They have a relatively low human toxicity level. They also have a low corrosion level and limited persistence. Pine oil 85% is derived from the needles of the Pine Tree, commonly recognized as the traditional Christmas tree. The scent of Pine oil 85% is known for having a clarifying, uplifting, and invigorating effect. Used in aromatherapy applications, Pine oil 85% positively impacts the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook. Used topically, Pine oil 85% is reputed to soothe itchiness, inflammation, and dryness, control excessive perspiration, prevent fungal infections, protect minor abrasions from developing infections, slow the appearance of signs of aging, and enhance circulation. When applied to the hair, Pine oil 85% is reputed to cleanse, enhance the hair’s natural smoothness and shine, contribute moisture, and protect against dandruff as well as lice. Used medicinally, Pine oil 85% is reputed to support immune function, clear the respiratory tract, address symptoms of colds, coughs, sinusitis, asthma, and the flu, and facilitate the healing of infections. Used in massage applications, Pine oil 85% is known to soothe inflammation, soreness, aches, pain, and gout; to stimulate and enhance circulation; to facilitate the healing of scratches, cuts, wounds, and burns; to promote the regeneration of new skin; to reduce pain; to relieve muscle fatigue; to promote the body’s detoxification; to maintain the health and function of the urinary tract and the kidneys; and to regulate body weight. HISTORY OF Pine oil 85% USAGE The Pine tree is easily recognized as the “Christmas Tree,” but it is also commonly cultivated for its wood, which is rich in resin and is thus ideal for use as fuel, as well as for making a pitch, tar, and turpentine, substances that are traditionally used in construction and painting. In folk tales, the height of the Pine tree has led to its symbolic reputation as a tree that loves the sunlight and is always growing taller in order to catch the beams. This is a belief that is shared throughout many cultures, which also refer to it as “The Master of Light” and “The Torch Tree.” Accordingly, in the region of Corsica, it is burned as a spiritual offering so that it can emit a source of light. In some Native American tribes, the tree is called “The Watchman of the Sky.” In history, the Pine tree’s needles were used as filling for mattresses, as they were believed to have the ability to protect against fleas and lice. In ancient Egypt, pine kernels, better known as Pine Nuts, were used in culinary applications. The needles were also chewed to protect against scurvy. In ancient Greece, Pine was believed to have been used by physicians like Hippocrates to address respiratory ailments. For other applications, the tree’s bark was also used for its believed ability to reduce symptoms of colds, to calm inflammation and headaches, to soothe sores and infections, and to ease respiratory discomforts. Today, Pine oil 85% continues to be used for similar therapeutic benefits. It has also become a popular aroma in cosmetics, toiletries, soaps, and detergents. This article highlights the various other benefits, properties, and safe uses of Pine oil 85%. Pine oil 85% BENEFITS It is believed to have cleansing, stimulating, uplifting, and invigorating effects. When diffused, its purifying and clarifying properties are known to positively impact the mood by clearing the mind of stresses, energizing the body to help eliminate fatigue, enhancing concentration, and promoting a positive outlook. These qualities also make it beneficial for spiritual practices, such as meditation. Used topically, such as in cosmetics, the antiseptic and antimicrobial properties of Pine oil 85% are known to help soothe skin conditions characterized by itchiness, inflammation, and dryness, such as acne, eczema, and psoriasis. These properties combined with its ability to help control excessive perspiration, may help prevent fungal infections, such as Athlete’s Foot. It is also known to effectively protect minor abrasions, such as cuts, scrapes, and bites, from developing infections. Its antioxidant properties make Pine oil 85% ideal for use in natural formulations intended to slow the appearance of signs of aging, including fine lines, wrinkles, sagging skin, and age spots. Furthermore, its circulation-stimulating property promotes a warming effect. When applied to the hair, Pine oil 85% is reputed to exhibit an antimicrobial property that cleanses to remove bacteria as well as a build-up of excess oil, dead skin, and dirt. This helps prevent inflammation, itchiness, and infection, which in turn enhances the hair’s natural smoothness and shine. It contributes moisture to eliminate and protect against dandruff, and it nourishes to maintain the health of the scalp and strands. Pine oil 85% is also one of the oils known to protect against lice. Used medicinally, Pine oil 85% is reputed to exhibit antimicrobial properties that support immune function by eliminating harmful bacteria, both airborne and on the skin’s surface. By clearing the respiratory tract of phlegm and soothing other symptoms of colds, coughs, sinusitis, asthma, and the flu, its expectorant and decongestant properties promote easier breathing and facilitate the healing of infections. Used in massage applications, Pine oil 85% is known to soothe muscles and joints that may be afflicted with arthritis and rheumatism or other conditions characterized by inflammation, soreness, aches, and pain. By stimulating and enhancing circulation, it helps facilitate the healing of scratches, cuts, wounds, burns, and even scabies, as it promotes the regeneration of new skin and helps reduce pain. It is also reputed to help relieve muscle fatigue. Additionally, its diuretic properties help promote the body’s detoxification by encouraging the expulsion of pollutants and contaminants, such as excess water, urate crystals, salts, and fats. This helps maintain the health and function of the urinary tract and the kidneys. This effect also helps regulate body weight. As illustrated, Pine oil 85% is reputed to have many therapeutic properties. The following highlights its many benefits and the kinds of activity it is believed to show: COSMETIC: Anti-Inflammatory, Anti-Oxidant, Deodorant, Energizing, Cleansing, Moisturizing, Refreshing, Soothing, Circulation-Stimulating, Smoothing ODOROUS: Calming, Clarifying, Deodorant, Energizing, Focus-Enhancing, Freshening, Insecticidal, Invigorating, Uplifting MEDICINAL: Antibacterial, Antiseptic, Anti-Fungal, Anti-Inflammatory, Antibacterial, Analgesic, Decongestant, Detoxifying, Diuretic, Energizing, Expectorant, Soothing, Stimulating, Immune-Enhancing Pine oil 85% USES By diffusing Pine oil 85%, whether on its own or in a blend, indoor environments benefit from the elimination of stale odors and harmful airborne bacteria, such as those that cause colds and the flu. To deodorize and freshen a room with the crisp, fresh, warm, and comforting aroma of Pine oil 85%, add 2-3 drops to a diffuser of choice and allow the diffuser to run for no more than 1 hour. This helps to reduce or clear nasal/sinus congestion. Alternatively, it may be blended with other essential oils that have woody, resinous, herbaceous, and citrusy aromas. In particular, Pine oil 85% blends well with the oils of Bergamot, Cedarwood, Citronella, Clary Sage, Coriander, Cypress, Eucalyptus, Frankincense, Grapefruit, Lavender, Lemon, Marjoram, Myrrh, Niaouli, Neroli, Peppermint, Ravensara, Rosemary, Sage, Sandalwood, Spikenard, Tea Tree, and Thyme. To create a Pine oil 85% room spray, simply dilute Pine oil 85% in a glass spray bottle filled with water. This can be sprayed around the house, in the car, or in any other indoor environment in which a considerable amount of time is spent. These simple diffuser methods are reputed to help purify indoor environments, promote mental alertness, clarity, and positivity, and to enhance energy as well as productivity. This makes Pine oil 85% ideal for diffusion during tasks that require increased focus and awareness, such as work or school projects, religious or spiritual practices, and driving. Diffusing Pine oil 85% also helps soothe coughing, whether it is linked to a cold or to excessive smoking. It is also believed to ease symptoms of hangovers. Massage blends enriched with Pine oil 85% are also reputed to have the same effects on the mind, helping to promote clarity, ease mental stresses, strengthen attentiveness, and improve memory. For a simple massage blend, dilute 4 drops of Pine oil 85% in 30 ml (1 oz.) of a body lotion or a carrier oil, then massage it into areas affected with tightness or soreness caused by physical exertion, such as exercise or outdoor activities. This is gentle enough for use on sensitive skin and is believed to soothe aching muscles as well as minor skin ailments, such as itching, pimples, eczema, psoriasis, sores, scabies. In addition, it is also reputed to soothe gout, arthritis, injuries, exhaustion, inflammation, and congestion. To use this recipe as a natural vapor rub blend that promotes easier breathing and soothes a sore throat, massage it into the neck, chest, and upper back to help reduce congestion and comfort the respiratory tract. For a hydrating, cleansing, clarifying, and soothing facial serum, dilute 1-3 drops of Pine oil 85% in 1 teaspoon of a lightweight carrier oil, such as Almond or Jojoba. This blend is reputed to have purifying, smoothing, and firming qualities. Its antioxidant properties are reputed to result in skin that feels smoother, suppler, balanced, and younger, while its analgesic properties are reputed to reduce pain and swelling. For a balancing and detoxifying bath blend that is also reputed to enhance energy as well as metabolic function and speed, dilute 5-10 drops of Pine oil 85% in 30 ml (1 oz.) of a carrier oil and add it to a bathtub filled with warm water. This helps to eliminate infection-causing bacteria and viruses that may be on the skin. To enhance the health of the hair and the scalp by eliminating fungus-causing bacteria and by soothing itchiness, simply dilute 10-12 drops of Pine oil 85% in ½ cup of a regular shampoo that has minimal or no scent. This simple shampoo blend is believed to help get rid of lice. PINE SCOTCH OIL SIDE EFFECTS As with all other New Directions Aromatics products, Pine oil 85% is for external use only. It is imperative to consult a medical practitioner before using this oil for therapeutic purposes. Pregnant and nursing women are especially advised not to use Pine oil 85% without the medical advice of a physician, as it may have an effect on certain hormone secretions and it is unclear whether these effects are transferable to babies at these stages of development. The oil should always be stored in an area that is inaccessible to children, especially those under the age of 7. Those with the following health conditions are recommended to be advised by a physician: cancer, heart-related ailments, skin disorders, hypertension, or hormone-related ailments. Individuals that are taking prescription drugs, undergoing major surgery, or who are at a greater risk of experiencing strokes, heart attacks, or atherosclerosis are also advised to seek medical consultation prior to use. Prior to using Pine oil 85%, a skin test is recommended. This can be done by diluting 1 drop of the Essential Oil in 4 drops of a Carrier Oil and applying a dime-size amount of this blend to a small area of skin that is not sensitive. Pine oil 85% must never be used near the eyes, inner nose, and ears, or on any other particularly sensitive areas of skin. Potential side effects of Pine oil 85% include mild irritation of the respiratory tract. Pine oil 85% is an essential oil obtained by the steam distillation of stumps,[2] needles, twigs and cones[3] from a variety of species of pine, particularly Pinus sylvestris. As of 1995, synthetic Pine oil 85% was the "biggest single turpentine derivative."[4] Synthetic Pine oil 85%s accounted for 90% of sales as of 2000. In alternative medicine, it is said to be used in aromatherapy, as a scent in bath oils or more commonly as a cleaning product, and as a lubricant in small and expensive clockwork instruments. It may also be used varyingly as a disinfectant, sanitizer, microbicide (or microbistat), virucide or insecticide.[6] It is also used as an effective herbicide where its
PINE TURPENTINE OIL
Pine turpentine oil, commonly known as turpentine oil or gum turpentine, is a natural essential oil derived from pine trees, particularly from the wood, resin, and stumps of pine trees.
Pine turpentine oil is composed primarily of monoterpenes such as α-pinene and β-pinene, along with other terpenes and organic compounds.

CAS Number: 8006-64-2
EC Number: 232-350-7

Synonyms: Turps, Pine oil, Wood turpentine, Gum turpentine, Spirits of turpentine, Oleum terebinthinae, Turpentine gum oil, Balsam turpentine, Turpentine resin oil, Terpentinöl, Pinus turpentine, Terebinth oil, Turpeth oil, Terebinthin, Oil of turpentine, Terebinthina, Gum spirits, Pinus palustris oil, Terebinthine, Pine gum, Terebenthene, Terebinthinate, Terebinthinate turpentine, Terebinthinate oil, Terebinthinic acid, Terebinthinized, Terebinthinate of soda, Terebinthinic alcohol, Turpentine of Pinus palustris, Terebinthinate of mercury, Terebinthinic, Terebinthene, Terebinthine camphor, Terebinthinous, Terebinthinate of potash, Terebinthinate of ammonia, Terebinthinate of lead, Terebinthinate of bismuth, Terebinthinate of copper, Terebinthinate of zinc, Terebinthinate of silver, Terebinthinate of iron, Terebinthinate of calcium, Terebinthinate of magnesium, Terebinthinate of barium, Terebinthinate of strontium, Terebinthinate of alumina



APPLICATIONS


Pine turpentine oil is widely used as a solvent in the formulation of paints, varnishes, and lacquers.
Pine turpentine oil serves as a thinner for oil-based paints, improving flow and application properties.
Artists use turpentine oil to clean brushes and palettes, as well as to thin oil paints for various techniques.

In woodworking, turpentine oil is used to dissolve and remove wood finishes and adhesives.
Pine turpentine oil is utilized in the production of printing inks to adjust viscosity and improve print quality.

Pine turpentine oil is added to furniture polishes and wood preservatives for its enhancing properties.
In the pharmaceutical industry, it has been used historically as a component in liniments and ointments for its potential therapeutic effects.

Pine turpentine oil is employed in the manufacture of perfumes and fragrances, contributing a pine-like scent.
Pine turpentine oil is a key ingredient in the formulation of cleaning products and degreasers due to its strong solvent properties.

Pine turpentine oil is used in the production of soaps and detergents to enhance cleaning effectiveness.
Pine turpentine oil is employed in the formulation of adhesives and sealants to improve viscosity and bond strength.

Pine turpentine oil serves as a solvent in the extraction of essential oils and natural plant compounds for aromatherapy and cosmetic products.
Pine turpentine oil is used in the agricultural sector as a component of pesticides and insect repellents.
Pine turpentine oil is added to air fresheners and deodorizers for its fresh, pine-like aroma.

Pine turpentine oil is utilized in the manufacture of candles and wax products to adjust melting points and improve fragrance dispersion.
In the textile industry, turpentine oil is used in the processing of fabrics and fibers to remove wax and sizing agents.

Pine turpentine oil is employed in the production of rubber and plastics as a processing aid and solvent.
Pine turpentine oil is used in the formulation of pharmaceutical capsules and tablets as a plasticizer.
Pine turpentine oil is added to some cosmetic products, such as creams and lotions, for its fragrance and solvent properties.

Pine turpentine oil is used in the formulation of flavorings and food additives, particularly in confectionery.
Pine turpentine oil serves as a lubricant and corrosion inhibitor in mechanical and industrial applications.

Pine turpentine oil is utilized in the formulation of floor waxes and polishes for its enhancing properties.
Pine turpentine oil is added to industrial and household cleaners for its degreasing and stain-removal capabilities.

Pine turpentine oil is used in the formulation of specialty chemicals and specialty coatings.
Pine turpentine oil is employed in the production of pharmaceutical intermediates and fine chemicals due to its versatile properties.

Pine turpentine oil is used in the formulation of industrial and household disinfectants and sanitizers.
Pine turpentine oil is added to automotive and industrial lubricants as a viscosity modifier and corrosion inhibitor.
Pine turpentine oil is employed in the production of specialty chemicals, including resin intermediates.

Pine turpentine oil serves as a flotation agent in the mining industry for separating minerals from ores.
Pine turpentine oil is utilized in the formulation of metalworking fluids to improve cutting and machining operations.

Pine turpentine oil is used in the formulation of drilling fluids in the oil and gas industry for its lubricating properties.
Pine turpentine oil is added to agricultural sprays and pest control products as a carrier solvent.

In the cosmetic industry, turpentine oil is used in the formulation of hair care products for its cleansing properties.
Pine turpentine oil is employed in the production of linoleum and rubber flooring as a plasticizer and binder.
Pine turpentine oil is used in the preservation and treatment of leather goods and textiles.

Pine turpentine oil serves as a component in the formulation of ink removers and stain removers.
Pine turpentine oil is added to paint strippers and graffiti removers for its effective solvent properties.
Pine turpentine oil is used in the formulation of industrial coatings and corrosion-resistant paints.

Pine turpentine oil is employed in the formulation of adhesive tapes and labels for their adhesive properties.
Pine turpentine oil is used in the production of printing blankets and rollers in the printing industry.

Pine turpentine oil is added to solvent-based airbrush paints and artistic mediums for its thinning properties.
Pine turpentine oil serves as a component in the formulation of asphalt and bitumen products for road construction.
Pine turpentine oil is used in the production of flavorings and fragrances for its aromatic qualities.

Pine turpentine oil is employed in the formulation of shoe polishes and leather care products.
Pine turpentine oil serves as a component in the production of veterinary medicines and animal care products.

Pine turpentine oil is used in the formulation of herbal remedies and natural health products.
Pine turpentine oil is added to candles and wax melts for its fragrance and melting point adjustment.

Pine turpentine oil is employed in the formulation of industrial and household solvents for cleaning and degreasing applications.
Pine turpentine oil is used in the preservation of historical artifacts and cultural heritage objects.
Pine turpentine oil is added to water-based paints and coatings as a coalescing agent and viscosity modifier.



DESCRIPTION


Pine turpentine oil, commonly known as turpentine oil or gum turpentine, is a natural essential oil derived from pine trees, particularly from the wood, resin, and stumps of pine trees.
Pine turpentine oil is composed primarily of monoterpenes such as α-pinene and β-pinene, along with other terpenes and organic compounds.

Pine turpentine oil is a colorless to pale yellow liquid with a strong, characteristic pine-like odor.
Pine turpentine oil is obtained through steam distillation of resin obtained from various species of pine trees.

Pine turpentine oil has a thin consistency and is highly volatile, evaporating quickly at room temperature.
Pine turpentine oil has a distinctive taste that is sharp and slightly bitter.
Pine turpentine oil is miscible with organic solvents and oils but only slightly soluble in water.

Pine turpentine oil is composed mainly of terpenes such as α-pinene and β-pinene, contributing to its aromatic properties.
Pine turpentine oil is known for its solvent properties, effectively dissolving resins, waxes, and oils.

Pine turpentine oil has been traditionally used as a topical liniment for its purported medicinal properties.
Pine turpentine oil is flammable and must be handled with caution around open flames or heat sources.

Pine turpentine oil has been used historically in folk remedies for its potential antiseptic and anti-inflammatory effects.
The aroma of turpentine oil is reminiscent of pine forests and fresh wood.

Pine turpentine oil has a long history of use in traditional and alternative medicine practices.
Pine turpentine oil is used as a solvent in the production of paints, varnishes, and lacquers.
Artists use it as a thinner for oil-based paints and as a brush cleaner in painting studios.

In industrial applications, it serves as a component in cleaning products and degreasers.
Pine turpentine oil has been employed in the manufacture of soaps, perfumes, and cosmetics for its fragrance.
Pine turpentine oil is used as a flavoring agent in some food products, particularly in candies and chewing gums.

Pine turpentine oil is sometimes added to personal care products for its fresh and clean scent.
Due to its natural origin, turpentine oil is biodegradable under appropriate conditions.
Pine turpentine oil is found in various concentrations depending on its intended use, from industrial to household applications.

Pine turpentine oil can cause irritation to the skin and mucous membranes if not properly diluted or handled.
Pine turpentine oil is important to store turpentine oil in tightly sealed containers away from direct sunlight and heat.
Inhalation of concentrated vapors should be avoided, as it may cause respiratory irritation.

Pine turpentine oil is used in agricultural applications as a pesticide and insect repellent.
Despite its traditional uses, the toxicity of turpentine oil limits its modern medical applications and necessitates careful handling and storage.



PROPERTIES


Physical Properties:

Appearance: Colorless to pale yellow liquid
Odor: Strong, characteristic pine-like odor
Density: Approximately 0.86 g/cm³ at 20°C
Melting Point/Freezing Point: -55°C
Boiling Point: Approximately 150-165°C
Flash Point: Approximately 35-45°C (closed cup)
Solubility in Water: Slightly soluble (negligible)
Solubility in Organic Solvents: Miscible with organic solvents such as ethanol, ether, and chloroform
Viscosity: Low viscosity, thin consistency
Vapor Pressure: Approximately 5 mmHg at 20°C


Chemical Properties:

Chemical Formula: Variable due to composition, primarily composed of terpenes (C10H16)
Main Components: α-pinene, β-pinene, and other terpenes
Functional Groups: Contains hydrocarbon chains and cyclic structures (monoterpenes)
Acidity/Basicity: Neutral pH
Reactivity: Reacts with oxidizing agents; flammable in the presence of air
Stability: Stable under normal conditions; avoid heat, flames, and direct sunlight
Flammability: Highly flammable liquid; vapors may form explosive mixtures with air
Autoignition Temperature: Approximately 255°C
Oxidation States: Mainly in the 0 oxidation state (hydrocarbons)
Hygroscopicity: Not hygroscopic; stable under dry conditions



FIRST AID


Inhalation

Remove to Fresh Air:
Immediately move the affected person to fresh air. Ensure they are breathing properly.

Monitor Breathing:
If the person is not breathing or if breathing is difficult, provide artificial respiration or oxygen if trained to do so.

Seek Medical Help:
Call a physician or emergency medical services (EMS) for further assistance.


Skin Contact

Remove Contaminated Clothing:
Take off any contaminated clothing and shoes immediately.

Wash Skin Thoroughly:
Wash the affected area with plenty of soap and water for at least 15 minutes.

Monitor for Symptoms:
Watch for signs of skin irritation or rash. If irritation persists, seek medical attention.

Launder Clothing:
Wash contaminated clothing thoroughly before reuse.


Eye Contact

Flush Eyes Immediately:
Rinse the affected eye(s) with lukewarm water for at least 15 minutes.
Hold eyelids open to ensure thorough rinsing.

Avoid Rubbing Eyes:
Do not allow the person to rub their eyes, as this can cause further irritation.

Seek Medical Help:
Get immediate medical attention if irritation persists or vision problems occur.


Ingestion

Do Not Induce Vomiting:
Do not induce vomiting unless instructed to do so by medical personnel.

Rinse Mouth:
Rinse the mouth with water immediately.

Give Water:
If the person is conscious and not having convulsions, give small amounts of water to drink.

Seek Medical Help:
Contact a physician or poison control center immediately.



HANDLING AND STORAGE


Handling:

Ventilation:
Use in a well-ventilated area to prevent buildup of vapors.
Avoid inhalation of vapors; use local exhaust ventilation if necessary.

Protective Equipment:
Wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and clothing to prevent skin contact.

Avoid Contact:
Minimize direct contact with skin, eyes, and clothing.
In case of skin contact, remove contaminated clothing and wash skin thoroughly with soap and water.

Avoid Ingestion:
Do not ingest.
Avoid eating, drinking, or smoking while handling turpentine oil.
Wash hands thoroughly after handling.

Spills:
Clean up spills immediately using absorbent materials.
Prevent spills from entering drains or water sources.
Dispose of contaminated materials properly according to local regulations.

Handling Containers:
Use properly labeled containers designed for storing flammable liquids.
Keep containers tightly closed when not in use.

Static Electricity:
Ground containers and equipment to prevent static discharge.
Avoid sparks and open flames.

Mixing:
Do not mix turpentine oil with oxidizing agents or strong acids as it may cause hazardous reactions.


Storage:

Location:
Store in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and ignition sources.

Temperature:
Store at temperatures below 25°C (77°F) to minimize vapor pressure and reduce fire hazard.

Container Size:
Use smaller containers to minimize air exposure and reduce the risk of vapor buildup.

Compatibility:
Store away from incompatible materials, including strong oxidizing agents and acids.

Fire Safety:
Store in areas designed for flammable liquids, equipped with adequate fire protection measures such as fire extinguishers and fire-resistant storage cabinets.

Security:
Restrict access to storage areas to authorized personnel only.
Ensure containers are securely sealed and labeled with appropriate hazard information.

Monitoring:
Regularly inspect containers for signs of damage or leaks.
Replace damaged containers promptly.

Emergency Planning:
Have emergency procedures in place, including spill response and fire evacuation plans.
Ensure personnel are trained in handling emergencies involving turpentine oil.
Pırasa Ekstraktı
Allium Porrum Extract; extract of the leek, allium porrum l., liliaceae; allium ampeloprasum var. porrum extract; extract of the leek, allium porrum l., liliaceae; leek extract cas no: 84650-15-7
PIROCTONE ETHANOLAMINE
Piroctone ethanolamine is a preservative that is also used in anti-dandruff shampoos for anti-fungal functions.
Piroctone ethanolamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.
Piroctone ethanolamine has anti-fungal properties and appears as a crystalline powder in raw form that is white or slightly yellow in color.

CAS Number: 68890-66-4
EC Number: 272-574-2
Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.42

Synonyms: PIROCTONE OLAMINE, 68890-66-4, Octopirox, Piroctone ethanolamine, Kopirox, Piroctoneolamine, Octopyrox, Piroctone ethanolamine salt, Piroctone olamine [USAN], C14H23NO2.C2H7NO, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, EINECS 272-574-2, UNII-A4V5C6R9FB, A4V5C6R9FB, NSC-759894, PIROCTONE ETHANOLAMINE SALT (1:1), Piroctone olamine (USAN), EC 272-574-2, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Octopirox (TN), SCHEMBL2843, CHEMBL2107154, PIROCTONE OLAMINE [INCI], PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE [USP-RS], AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone olamine, analytical standard, AKOS025149526, CCG-267454, CS-7659, NSC 759894, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, C14-H23-N-O2.C2-H7-N-O, LS-133057, FT-0653357, P2178, D05505, Piroctone ethanolamine salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1- hydroxy- 4- methyl- 6- (2, 4, 4- trimethylpentyl)pyridin- 2(1H)- one, compound with 2- aminoethanol (1:1), Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon --2-aminoethanol (1:1) [German] [ACD/IUPAC Name], 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1) [ACD/IUPAC Name], 1-Hydroxy-4-méthyl-6-(2,4,4-triméthylpentyl)-2(1H)-pyridinone - 2-aminoéthanol (1:1) [French] [ACD/IUPAC Name], 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-Aminoethanol Salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1) [ACD/Index Name], 272-574-2 [EINECS], 68890-66-4 [RN], A4V5C6R9FB, MFCD01690792, octopirox [Trade name], Piroctone ethanolamine, Piroctone ethanolamine salt, Piroctone olamine [Wiki], UNII:A4V5C6R9FB, [68890-66-4] [RN], 1-Aminoethane, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanol ammonium salt, 1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), 2-aminoethanol and 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, 2-hydroxyethylammonium; 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, Octopirox| Piroctone ethanolamine, Piroctone, Piroctone olamin, PIROCTONE OLEAMINE, QA-6124

Piroctone ethanolamine is a compound sometimes used in the treatment of fungal infections.
Piroctone ethanolamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Piroctone ethanolamine is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione.
Piroctone ethanolamine is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.

Piroctone ethanolamine is a preservative that is also used in anti-dandruff shampoos for Piroctone ethanolamine anti-fungal functions.

Pyrithione zinc, also known as Piroctone ethanolamine, was developed as a solution to the problem of seborrheic dermatitis, that is, dandruff, and has antibacterial, antimicrobial and antifungal properties that can help treat scalp psoriasis and acne.
The mentioned properties can destroy fungi, bacteria and microorganisms that can cause itchy complaints in the hair and scalp and cause the scalp to become flaky.

Piroctone ethanolamine has the potential to have antifungal effects to prevent or treat fungal infections.
Piroctone ethanolamine helps reduce inflammation in the skin.

Piroctone ethanolamine provides antioxidant effect by protecting the skin from the harmful effects of free radicals.
Piroctone ethanolamine shows cleansing potential to remove dirt, oil and debris.
Piroctone ethanolamine can help eliminate bad odors.

Piroctone ethanolamine is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
Piroctone ethanolamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.

Piroctone ethanolamine is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Shampoos with Piroctone ethanolamine are very effective in curing dandruff and preventing hair loss.

Piroctone ethanolamine has anti-fungal properties and appears as a crystalline powder in Piroctone ethanolamine raw form that is white or slightly yellow in color.
Further, Piroctone ethanolamine is slightly soluble in oil and water.
The chemical formula of Piroctone ethanolamine is C14H23NO2.C2H7NO.

Piroctone ethanolamine has a petrochemical origin.
Piroctone ethanolamine is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.
Typically, Piroctone ethanolamine is an alternative to the commonly used compound zinc pyrithione.

Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing Piroctone ethanolamine are effective in treating various kinds of hair problems.

Piroctone ethanolamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone ethanolamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Piroctone ethanolamine is a pyridone derivative, which is known to have bactericidal effects on gram-positive and gram-negative bacteria and fungicidal effects and hence is a component of many cosmetic products such as anti-dandruff shampoo.

Piroctone ethanolamine, also called Octopirox, is an antifungal of the hydroxy-pyridone family unrelated to other antiseptics used in veterinary medicine.
Members of the “pirox” family are currently used in the human field as topicals to cure onychomycosis and Malassezia-related skin disorders.

Piroctone ethanolamine has broad in vitro activity against major dermal veterinary pathogens, including dermatophytes and yeasts as well as some Gram positive (Staphylococcus) and Gram negative (Pseudomonas) bacteria.
As opposed to azole derivatives, PO remains fully active on resting fungal cells; Piroctone ethanolamine antiseptic activity proceeds from inhibition of the respiratory chain in yeast mitochondria.

No resistance to PO has been documented to date.
In addition, this antiseptic acts at low concentrations, has high affinity for keratin and is completely safe.
Incorporation of PO in Allermyl therefore aims at controlling microbial proliferation associated with allergic disease.

Piroctone ethanolamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Piroctone ethanolamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Piroctone ethanolamine is known for many years as a successor to Ketoconazole as an excellent anti-dandruff agent.
More recently Piroctone ethanolamine has been discovered that Piroctone ethanolamine has a much broader protection range against all kinds of microbiological species.

Is also being used in many preservative formulations at neutral pH, which is important for sunscreen formulations.

Piroctone ethanolamine is slightly soluble in both water and oil.
Freely soluble in 10% ethanol in water.

Soluble in solutions containing surfactants in water or in 1-10% ethanol.
The solubility of Piroctone ethanolamine in water varies by pH value.
This is a little larger in neutral or weak basic solutions than in acid solutions.

Typical use level is only 0.05 – 0.2%.

Piroctone ethanolamine is a hydroxamic acid that inhibits ergosterol synthesis, the main component of the cell wall of most fungi.
Piroctone ethanolamine is used as a cream or shampoo at a 0.5–1% concentration.

Piroctone ethanolamine alone or in combination with other agents has been demonstrated to reduce erythema, scaling, burning/stinging sensation, and pruritus in patients with FSD, with excellent cosmetic results.
Piroctone ethanolamine is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Designed specifically to treat seborrheic dermatitis and dry scalp, Piroctone ethanolamine offers additional benefits: Piroctone ethanolamine is environmentally friendly, multifunctional (doubles as preserving agent), and flexible for various cosmetic formats.
Piroctone ethanolamine is compatible with most surfactants, additives and active ingredients used in cosmetic formulations.

Piroctone ethanolamine is an effective, practically nontoxic antidandruff active ingredient.
Piroctone ethanolamine is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone ethanolamine is a highly effective antidandruff agent and an anti-acne active agent.
Piroctone ethanolamine is antimicrobial, soluble in surfactant systems.
Piroctone ethanolamine is used shampoos, shower products, liquid soaps, hair conditioners, hair styling products, antiperspirant & deodorants.

Piroctone ethanolamine, despite the recent upsurge in usage, has historically not been a hugely popular ingredient.
So very few independent clinical studies have been performed.
Piroctone ethanolamine main advantage is that it’s well tolerated, and so can be used frequently to control mild dandruff, but this hasn’t been properly evaluated.

Piroctone ethanolamine is one of the more recent active ingredients found in dandruff shampoos.
Designed to treat seborrheic dermatitis and dry scalp Piroctone ethanolamine is one of the most innovative areas of dandruff treatment on the market today.

Dandruff and seborrheic dermatitis can cause hair loss and thinning hair.
Piroctone ethanolamine is assumed that dandruff and seborrheic dermatitis (dandruff is a form of seborrheic dermatitis) are caused by a yeast (single cell fungus) on the skin, the Malassezia globose.
This is a fungus that occurs only on the scalp.

Often times, the problem will not go away on Piroctone ethanolamine own and requires continues treatment.
A well-known agent for this is shampoo with Ketoconazole in high concentration.
Multiple studies about the effectiveness of Piroctone ethanolamine have shown that Piroctone ethanolamine stimulates hair growth and helps against hereditary hair loss.

Ketoconazole is most well-known, but Piroctone ethanolamine is not the only proven anti-dandruff ingredient in shampoos which stimulates hair growth.
Piroctone ethanolamine has a similar effect as Ketoconazole.

Piroctone ethanolamine is also listed under the brand name 'Octopirox'.
In a study with 150 men who suffer from hereditary hair loss and dandruff, Ketoconazole and Piroctone ethanolamine were compared.

Excessive secretion of sebum, dandruff and seborrheic dermatitis are often linked with hair loss and hereditary hair loss.
The 150 men received a shampoo with 1% Ketoconazole or 1% Piroctone ethanolamine.
They had to use this shampoo 2 to 3 times per week for a duration of six months.

All treatments showed a reduction in itching and dandruff after 2 to 6 weeks.

If we take a look at the effect of the treatments on various hair growth parameters, we see the following figures (in percentages):
The severity of hair loss decreases (Ketoconazole: -17.3%, Piroctone ethanolamine: -16.5%)

The percentage of hairs in the growth phase increases (Ketoconazole 4.9%, Piroctone ethanolamine: 7.9%)
The effect on the hair diameter is increased by 5.4% with Ketoconazole and by 7.7% with Piroctone ethanolamine.

Thus, the study shows that Piroctone ethanolamine scores better in a number of areas in comparison to Ketoconazole.

Compared to Ketoconazole, Piroctone ethanolamine ensures an increase in the number of hairs in the growth phase (anagen phase) by more than 10% in 33% of people.
Piroctone ethanolamine gives 88% of the people thicker hair, despite hereditary hair loss, whereby this is 78% with Ketoconazole.
If we take a look at how many people experience a significant increase (more than 10%) of the hair diameter, this is 28% with Ketoconazole and as much as 34% with Piroctone ethanolamine (10% larger diameter means that the hair became 20% heavier).

The above results show that both Ketoconazole and Piroctone ethanolamine have a positive effect on multiple aspects of hair growth.
They have a similar effect on itch and dandruff.
Piroctone ethanolamine generally scores better when Piroctone ethanolamine comes to hair growth.

Piroctone ethanolamine is a preservative also used for Piroctone ethanolamine antifungal functions in anti-dandruff shampoos.
Piroctone ethanolamine is forbidden in organic.

Restriction in Europe:
Maximum concentration in ready-to-use preparation

Maximum content of secondary amine: 0.5%

Other restrictions:
Do not use with nitrosating systems
Minimum purity: 99%
Maximum content of secondary amine: 0.5% (applies to raw materials)
Maximum nitrosamine content: 50 micrograms / kg
Keep in containers without nitrite

If used as a conservator:

The maximum concentration allowed in ready-to-use cosmetic preparations is:
1.0% in Piroctone ethanolamines to be rinsed
0,5% in other products

Applications of Piroctone ethanolamine:
Piroctone ethanolamine is quite beneficial in maintaining cosmetic and personal care products.
Piroctone ethanolamine can commonly be found in products like shampoos, cleansers, and hair masks.

Skin care:
Piroctone ethanolamine can be used to eliminate the bad odor from the surface of the skin.
Piroctone ethanolamine is a great preservative that helps in keeping skin care products free from bacterial growth.

Hair care:
Piroctone ethanolamine is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone ethanolamine is also good for preventing hair loss and split ends.

Cosmetic products:
In cosmetic products, Piroctone ethanolamine makes use of Piroctone ethanolamine antifungal properties to keep Piroctone ethanolamines free from unwanted bacterial growth for a longer time.
The addition of Piroctone ethanolamine improves the quality of Piroctone ethanolamines and makes them last longer.

Uses of Piroctone ethanolamine:
Piroctone ethanolamine is a broad-spectrum microbiocide/microbiostat, may be used in formulating antidandruff shampoo, hair keep and hair care, soap, etc.

Piroctone ethanolamine is used in shampoo, hair care, bath liquid, cosmetics, skin care products and washing products.
Piroctone ethanolamine has a unique effect in relieving skin itching, with excellent anti-itch effect, can effectively kill fungi on the skin, and has a special effect in eliminating body odor.
Piroctone ethanolamine is a safe, non-toxic, non-stimulating, ideally effective fungicide.

Piroctone ethanolamine anti-dandruff and anti-itch effect is superior to similar products.
Excellent solubility and compound performance, no precipitation or stratification when mixed with cosmetic raw materials.
Unique anti-dandruff mechanism, very low irritation, no hair loss, no hair breakage, safety is better than similar anti-dandruff anti-itch products.

Suggested use:
One in every three persons suffers from a problem related to their hair.
Whether Piroctone ethanolamine is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.

And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.

The most effective are not usually the ones which are famous (as anything can become famous if Piroctone ethanolamine is marketed and advertised well), they are the ones that have the appropriate ingredients.
Piroctone ethanolamine is the answer to that question.

Rate of Application:
Antidandruff hair keep: 0.1-0.8% active ingredient.
Antidandruff fixing agent: 0.05-0.2% active ingredient.

Antidandruff hair emulsion: 0.1-0.3% active ingredient.
Antidandruff hair supporting: 0.05-0.1% active ingredient.

Preservative: 0.2-0.5% active ingredient

Smell-eliminating agent: 0.2-0.5% active ingredient
Smell-eliminating scented soap: 0.2-0.5% active ingredient.

Consumer Uses:
Piroctone ethanolamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Other release to the environment of Piroctone ethanolamine is likely to occur from: indoor use as processing aid.

Widespread uses by professional workers:
Piroctone ethanolamine is used in the following products: cosmetics and personal care products.
Piroctone ethanolamine is used for the manufacture of: chemicals.
Other release to the environment of Piroctone ethanolamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Uses at industrial sites:
Piroctone ethanolamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Piroctone ethanolamine is used for the manufacture of: chemicals.
Release to the environment of Piroctone ethanolamine can occur from industrial use: in processing aids at industrial sites and in the production of articles.

Benefits of Piroctone ethanolamine:
Piroctone ethanolamine has been specially developed to solve dandruff problems.
Piroctone ethanolamine prevents the scalp from flaking.

Piroctone ethanolamine contributes to the purification of hair roots from bacteria and fungi.
Piroctone ethanolamine is effective in eliminating the factors that cause itching at the roots of the hair.
Piroctone ethanolamine helps purify and cleanse the hair and scalp.

Shampoos, which have Piroctone ethanolamine as one of their ingredients, are known to eliminate dandruff.
However, before we learn how they cure dandruff, we must know what causes dandruff in the first place.

Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations.
Often all these together cause dandruff.

Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.
Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.

This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.
The reason why shampoos with Piroctone ethanolamine can reduce and eliminate dandruff is that Piroctone ethanolamine is known to kill the fungus or the fungal infections that irritate the scalp.

Moreover, Piroctone ethanolamine is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone ethanolamine is considered a great ingredient in shampoos.

Cures Dandruff:
Malassezia Globosa is not a friendly fungus found in your scalp.
Piroctone ethanolamine is the main reason behind scalp issues like dandruff and seborrheic dermatitis.

Your scalp becomes irritated and starts shedding tiny flakes.
In severe cases, you will notice inflammation, redness, and extremely itchy patches.
If you want to prevent your scalp from worsening, it’s essential to control the situation promptly.

Piroctone ethanolamine has antifungal properties, which will help you control the spread of Malassezia globosa.
Use an anti-dandruff shampoo containing Piroctone ethanolamine to fight dandruff.

Prevents Hair Loss:
Regardless of your gender and age, you may face hair fall, mostly caused due to dirt, dust, pollution, dandruff, excessive use of hair styling tools, etc.
Dandruff makes your scalp itchy, which leads to constant scratching, redness, and hair follicle damage.

Even though hair fall due to dandruff is not a significant concern but in people with androgenic alopecia (a condition that leads to baldness), Piroctone ethanolamine is a proven cure for reducing hair fall.
As Piroctone ethanolamine effectively works on dandruff and fungal infections, naturally, your hair loss decreases over time.

Boosts Hair Growth:
Piroctone ethanolamine encourages hair growth in many ways.
Piroctone ethanolamine reduces hair fall and increases the hair diameter.
Piroctone ethanolamine is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone ethanolamine provides better results for dandruff and fungal infections.

Ketoconazole + Piroctone ethanolamine is a combination of two antifungal medicines:
Ketoconazole and Piroctone ethanolamine which treat dandruff.

Ketoconazole kills fungi by destroying the fungal cell membrane.
Piroctone ethanolamine works by penetrating the cell membrane of the fungi to interfere with their energy metabolism and oxygen uptake.
This kills the fungi and clears up the infection.

Functions of Piroctone ethanolamine:

Preservative:
Inhibits the development of microorganisms in cosmetic products.

Anti dandruff:
Helps fight against dandruff.
Piroctone ethanolamine is an active, dandruff-fighting ingredient used in some of our shampoos.

Characteristics of Piroctone ethanolamine:
Piroctone ethanolamine is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp.
Piroctone ethanolamine also reduced sebum production.

Appearance of Piroctone ethanolamine:
Piroctone ethanolamine has a white crystalline powder structure.

Resolution
Piroctone ethanolamine has low solubility in water.
Piroctone ethanolamine dissolves better in some organic compounds.

Solubility of Piroctone ethanolamine:
The solubility of Piroctone ethanolamine is greatly dependent on the pH.
Generally speaking, Piroctone ethanolamine solubility in aqueous formulations is greater in the neutral and weakly alkaline ranges than in the acid range (formation of free acid).
Piroctone ethanolamine does however have adequate solubility in the usual pH range (pH5 - 8) in commercial surfactant solutions and alcohol-water mixtures.

Extraction method of Piroctone ethanolamine:
Piroctone ethanolamine is a particular salt that is also known as Octopirox and Piroctone olamine.
Piroctone ethanolamine is a compound, which is often used to cure fungal infections.
Piroctone ethanolamine is a hydroxamic acid derivative Piroctone.

Origin of Piroctone ethanolamine:
Piroctone ethanolamine is of petrochemical origin and helps treat dandruff.
There is no natural alternative that comes close to being as effective as this.

History of Piroctone ethanolamine:
Piroctone ethanolamine has been used for around 40 years, first developed by Schwarzkopf-Henkel for use in anti-dandruff shampoo in the late 1970s.
All the initial clinical and safety studies were conducted by Hoechst AG, but this changed in the mid-1990s when other cosmetics companies began using the ingredient.

Piroctone ethanolamine was first submitted for approval to the European Union and United States FDA in the 1980s.
The ingredient was first approved for addition to the United States Pharmacopeia (USP) in 2008, after the FDA sought additional safety and effectiveness data in 2004.

Handling and storage of Piroctone ethanolamine:

Advice on safe handling:
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.

Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.

Storage stability:

Recommended storage temperature: 2 - 8 °C

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and reactivity of Piroctone ethanolamine:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

Incompatible materials:
Strong acids and oxidizing agents, Strong oxidizing agents

Health Effect of Piroctone ethanolamine:
If used as a preservative, Piroctone ethanolamine should be used at a maximum rate of 1.0% in rinsed products and at a maximum rate of 0.5% in other products.
Piroctone ethanolamine should not be used together with nitrosamine-forming agents.

Nitrosamines are carcinogenic substances.
The impurity rate should be 99%.

The maximum amount of secondary amine should be 0.5%.
The maximum amount of nitrosamine cannot exceed 50 micrograms/kg. The raw material should be stored in nitrite-free packaging.

Piroctone ethanolamine is a synthetic component.
They are raw materials produced using various processes under laboratory conditions.

These are raw materials obtained without using animal sources (propolis, honey, beeswax, lanolin, collagen, snail extract, milk, etc.).
Piroctone ethanolamine is a criterion that should be taken into consideration for those who want to use vegan products.

Studies have concluded that different effects can be seen on each skin type.
For this reason, the allergy/irritation effect may vary from person to person.
However, Piroctone ethanolamine causes stinging, tingling, itching, redness and irritation, especially in people with sensitive skin types.

Precaution of Piroctone ethanolamine:
However, just like excess of anything is bad, too much of Piroctone ethanolamine can be bad for the scalp too.
This is precisely why shampoos with Piroctone ethanolamine have a very minor amount of Piroctone ethanolamine so that its side effects do not affect the scalp in any way.

Piroctone ethanolamine should be kept in mind that shampoos with Piroctone ethanolamine should not be used more than twice a week, unlike other daily use shampoos that don’t have this ingredient.
One of the biggest side effects of Piroctone ethanolamine is that it can cause irritation and itchiness on the head.

First aid measures of Piroctone ethanolamine:

General advice:
Consult a physician.

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.

In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures of Piroctone ethanolamine:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from Piroctone ethanolamine:
Carbon oxides
Nitrogen oxides (NOx)

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

Further information:
No data available

Accidental release measures of Piroctone ethanolamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid dust formation.

Avoid breathing vapors, mist orgas.
Ensure adequate ventilation.

Evacuate personnel to safe areas.
Avoid breathing dust.

Environmental precautions of Piroctone ethanolamine:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Identifiers of Piroctone ethanolamine:
CAS Number: 68890-66-4
ChemSpider: 45574
ECHA InfoCard: 100.065.957
MeSH: Piroctone+olamine
PubChem CID: 50258
UNII: A4V5C6R9FB
CompTox Dashboard (EPA): DTXSID4046735
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYAP
SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

CAS NO: 68890-66-4
EC NO: 272-574-2

Synonym(s): 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
CAS Number: 68890-66-4
Molecular Weight: 298.42
EC Number: 272-574-2
MDL number: MFCD01690792
PubChem Substance ID: 329757760
NACRES: NA.24

Product Number: P2178
Purity / Analysis Method: >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight: C14H23NO2·C2H7NO = 298.43
Physical State (20 deg.C): Solid
Storage Temperature: 0-10°C
Condition to Avoid: Heat Sensitive
CAS No: 68890-66-4
Related CAS No: 50650-76-5
Reaxys Registry Number: 7503297
PubChem Substance ID: 253662076
Merck Index (14): 7502
MDL Number: MFCD01690792

Properties of Piroctone ethanolamine:
Chemical formula: C16H30N2O3
Molar mass: 298.421

Molecular weight: 298.43
Formula: C14H23NO2·C2H7NO
Purity: >97.0%(T)(HPLC)
Color/Form: White to Almost white powder to crystal
MDL: MFCD01690792
Melting point: 136 °C
Flash point: 136 °C
HS code: 2933790090

grade: analytical standard
Quality Level: 100
Assay: ≥99.0% (HPLC)
shelf life: limited shelf life, expiry date on the label

technique(s)
HPLC: suitable
gas chromatography (GC): suitable

application(s):
agriculture
environmental

format: neat
storage temp.: 2-8°C
SMILES string: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C
InChI: 1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChI key: BTSZTGGZJQFALU-UHFFFAOYSA-N

Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 298.22564282 g/mol
Monoisotopic Mass: 298.22564282 g/mol
Topological Polar Surface Area: 86.8Ų
Heavy Atom Count: 21
Complexity: 371
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Specification of Piroctone ethanolamine:
Appearance: White or slightly yellow crystalline powder
Odor: Characteristic

Solubility:
Water (0.10g +10ml):non-soluble
Methanol (1.00g + 10ml): soluble

Purity(HPLC) %: ≥99.0
PH value(1% aqueous suspension,20℃): 8.5-10.0
Melting Point ℃: 130-135
Drying loss %: ≤0.3
Ash(SO4) %: ≤0.2
Particle size distribution: D(0.5): 30-50um Provide a profile representative of the raw material
E1% (1cm) at 317 nm expressed an dried substance: 214-236
Ethanolamine %: 20.0-21.0
Nitrosamine content PPB: ≤50
Heavy metals(Pb,As,Cd,Co,Cr,Hg,Ni,Sb) PPM: ≤10
Hexane(GC) PPM: ≤300
Ethyl acetate(GC) PPM: ≤5000

Names of Piroctone ethanolamine:

Regulatory process names:
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon, monoethanolamine salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1)
Kopirox
Octopirox
Piroctone ethanolamine salt
Piroctone olamine

IUPAC names:
(RS)-1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2(1H)-PYRIDINONE ETHANOLAMINE (1:1)
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpently)pyridin-2-(1H)-one compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one,compound with 2-aminoethanol (1:1)
1-hydroxy-4methyl-6-(2,4,4-trimethylphenyl)pyridine-2(1H)-one, compound with 2-aminoethanol(1:1)
2-aminoethanol; 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-amminoetanolo; 1-idrossi-4-metil-6-(2,4,4-trimethylpentyl) pyridin-2-one
Octopirox
Piroctone Olamine
Piroctone Olamine
Piroctone olamine

Trade names:
Picroctone Olamine
Piroctone olamine

Other identifier:
68890-66-4
PIROCTONE OLAMINE

Piroctone olamine is a white crystalline powder with a faint characteristic odor.
Piroctone olamine exhibits a high level of purity and is soluble in various solvents.
Piroctone olamine is often described as a biologically active compound with antifungal and antibacterial properties.

CAS Number: 68890-66-4
EC Number: 272-574-2

Octopirox, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridinol, 2-Hydroxy-1-methyl-6-(2,4,4-trimethylpentyl)-4-pyridinol, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-pyridin-2(1H)-one, 2-Hydroxy-1-methyl-6-(2,4,4-trimethylpentyl)-pyridin-4-one, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, Piroctone monoethanolamine, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone, 2-Hydroxy-1-methyl-6-(2,4,4-trimethylpentyl)-4-pyridone, 2-Hydroxy-1-methyl-6-(2,4,4-trimethylpentyl)-pyridin-4-one, 2-Hydroxy-1-methyl-6-(2,4,4-trimethylpentyl)-pyridone, 4-Methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone, 4-Methyl-6-(2,4,4-trimethylpentyl)-2-pyridinol, 4-Methyl-6-(2,4,4-trimethylpentyl)-pyridin-2(1H)-one, 4-Methyl-6-(2,4,4-trimethylpentyl)-pyridin-2-one, 6-(2,4,4-Trimethylpentyl)-1-hydroxy-4-methyl-2(1H)-pyridone, 6-(2,4,4-Trimethylpentyl)-1-hydroxy-4-methyl-2-pyridinol, 6-(2,4,4-Trimethylpentyl)-1-hydroxy-4-methyl-2-pyridone, 6-(2,4,4-Trimethylpentyl)-4-methyl-2(1H)-pyridinone, 6-(2,4,4-Trimethylpentyl)-4-methyl-2-pyridinol, 6-(2,4,4-Trimethylpentyl)-4-methyl-pyridin-2(1H)-one, 6-(2,4,4-Trimethylpentyl)-4-methyl-pyridin-2-one, 6-(2,4,4-Trimethylpentyl)-4-methylpyridin-2(1H)-one, 6-(2,4,4-Trimethylpentyl)-4-methylpyridin-2-one, 6-(2,4,4-Trimethylpentyl)-1-hydroxy-4-methylpyridin-2(1H)-one, 6-(2,4,4-Trimethylpentyl)-1-hydroxy-4-methylpyridin-2-one, 6-(2,4,4-Trimethylpentyl)-2(1H)-pyridinone-4-methyl, 6-(2,4,4-Trimethylpentyl)-2-pyridinol-4-methyl, 6-(2,4,4-Trimethylpentyl)-2-pyridone-4-methyl, 6-(2,4,4-Trimethylpentyl)-pyridin-2(1H)-one-4-methyl, 6-(2,4,4-Trimethylpentyl)-pyridin-2-one-4-methyl, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-2(1H)-one-4-methyl, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-2-pyridone-4-methyl, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-4-methyl-2(1H)-one, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-4-methyl-2-pyridinol, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-4-methyl-2-pyridone, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-4-methylpyridin-2(1H)-one, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-4-methylpyridin-2-one, 6-(2,4,4-Trimethylpentyl)-pyridin-4-ol-4-methylpyridin-4-one



APPLICATIONS


Piroctone olamine finds extensive application in antidandruff shampoos, where it effectively targets and controls the growth of dandruff-causing fungi on the scalp.
Piroctone olamine is commonly used in skincare formulations, including creams and lotions, to combat fungal and bacterial skin infections.
Personal care products such as shower gels and body washes often incorporate Piroctone olamine for its antimicrobial properties.

Piroctone olamine is utilized in facial cleansers to address skin conditions related to fungi and bacteria, contributing to clearer skin.
Hair conditioners and treatments benefit from the addition of Piroctone olamine to promote a healthy scalp environment.
Scalp tonics and serums may contain this compound to provide targeted relief from conditions like seborrheic dermatitis.

Piroctone olamine is an essential ingredient in specialized foot creams and powders designed to address fungal infections.
In antiperspirants and deodorants, it contributes to the prevention of microbial growth that can lead to unpleasant odors.

Piroctone olamine is incorporated into hand sanitizers and antibacterial soaps for its skin-friendly antimicrobial action.
Piroctone olamine is used in formulations for intimate hygiene products to maintain a balanced microbial environment.

Piroctone olamine plays a role in the development of sunscreens and sun care products, enhancing their microbial stability.
Baby care products, including shampoos and lotions, may contain Piroctone olamine to ensure gentle yet effective protection.
Facial masks and peels utilize the compound's antimicrobial properties to address skin concerns and promote a clear complexion.

Piroctone olamine is employed in nail care products to combat fungal infections and promote overall nail health.
Medicated wipes for various skin conditions often incorporate this compound for its targeted antimicrobial benefits.

Piroctone olamine is used in veterinary formulations, such as pet shampoos, to address fungal and bacterial skin issues in animals.
In textile applications, it may be added to fabrics to impart antimicrobial properties, contributing to hygiene in clothing.

Piroctone olamine is applied in the preservation of cosmetic and personal care products, extending their shelf life.
Piroctone olamine's versatile antimicrobial action makes it suitable for inclusion in a wide range of dermatological preparations.

Piroctone olamine is used in pharmaceutical formulations for topical treatments aimed at addressing fungal and bacterial skin infections.
Piroctone olamine is employed in wound care products, contributing to infection prevention and enhanced healing.

Oral care products, including toothpaste and mouthwash, may contain this compound for its antimicrobial benefits.
Acne treatments and formulations for problematic skin conditions may incorporate Piroctone olamine for its antibacterial properties.

Piroctone olamine is utilized in the development of antifungal and antibacterial gels for various dermatological applications.
Piroctone olamine continues to be a key ingredient in the innovation of new personal care solutions, addressing a wide range of skin and hair concerns.
Piroctone olamine is a crucial component in anti-acne formulations, contributing to the control of bacterial growth on the skin.

Piroctone olamine is featured in facial cleansers targeting specific skin concerns, providing a comprehensive approach to microbial balance.
In hand creams and moisturizers, Piroctone olamine helps maintain skin health by preventing fungal and bacterial issues.
Specialized wound healing ointments may incorporate this compound for its antimicrobial properties to reduce the risk of infections.

Piroctone olamine is used in hair serums to address scalp issues and promote overall hair and scalp well-being.
Cosmetics like foundations and concealers may include the compound to offer additional protection against skin infections.
Sunscreen lotions containing Piroctone olamine provide not only sun protection but also microbial stability for healthier skin.

Piroctone olamine is employed in intimate washes and wipes to support a balanced microbial environment in sensitive areas.
Piroctone olamine is found in facial toners designed to soothe and balance the skin while addressing microbial concerns.
Nail lacquers and cuticle creams utilize this compound to prevent and alleviate fungal infections in the nail bed.

In antifungal foot powders, Piroctone olamine contributes to keeping the feet dry and free from fungal growth.
Textile coatings for sportswear and activewear may contain this compound to inhibit the growth of microbes, reducing odors.
Piroctone olamine is utilized in the formulation of antibacterial body sprays and mists for on-the-go hygiene.

Piroctone olamine is added to exfoliating scrubs to enhance their effectiveness in promoting a clear and healthy complexion.
Piroctone olamine is applied in the development of barrier creams, providing protection against microbial irritants.
Veterinary shampoos and grooming products for pets may contain this compound to address skin conditions.

Mouth rinses and oral care solutions may incorporate Piroctone olamine for its role in maintaining oral hygiene.
Dermatological creams and ointments for eczema and psoriasis can benefit from the compound's anti-inflammatory properties.

Piroctone olamine is featured in pre-shave and after-shave products to prevent and soothe potential microbial irritation on the skin.
Piroctone olamine is used in the formulation of cleansing wipes for quick and convenient hygiene on the go.
Scalp masks and treatments may contain this compound to address specific scalp conditions beyond dandruff.

In hair coloring products, it contributes to the overall formula's stability and microbial control.
Piroctone olamine is used in exfoliating foot masks to enhance their effectiveness in addressing foot skin concerns.

Personal lubricants and intimate care products may incorporate this compound for its gentle antimicrobial action.
Tattoo aftercare creams may contain Piroctone olamine to support healing and prevent infections in tattooed skin.

Piroctone olamine is employed in scalp scrubs, offering a deep-cleansing solution while addressing microbial imbalances.
Foot sprays and deodorants may contain this compound to combat fungal growth and maintain foot hygiene.

Piroctone olamine is utilized in exfoliating face masks, contributing to both skin renewal and microbial control.
Piroctone olamine is featured in leave-in hair treatments to provide prolonged protection against scalp issues.

Piroctone olamine is added to shaving creams and gels to prevent irritation and microbial-related skin problems.
Piroctone olamine is used in the development of mild and effective facial soaps for daily cleansing routines.

In hair growth serums, it supports a healthy scalp environment for optimal hair growth.
Piroctone olamine is employed in soothing skin balms, offering relief for irritated or sensitive skin.
Feminine hygiene products, such as washes and wipes, may include this compound for microbial balance.

Piroctone olamine is added to cooling gels and lotions, providing relief for irritated and overheated skin.
Piroctone olamine is used in multi-action skincare products to address a range of skin concerns simultaneously.

Piroctone olamine is included in overnight masks to promote skin regeneration and inhibit microbial growth.
Piroctone olamine is used in the formulation of dermatological ointments for targeted skin conditions.
In hair mists and refreshing sprays, it helps maintain a clean and healthy scalp between washes.

Piroctone olamine is found in hair primers, contributing to the overall health and resilience of the hair.
Piroctone olamine is applied in cuticle oils to support the health of nails and surrounding skin.
Piroctone olamine is used in hair styling products to provide both style and scalp protection.

Piroctone olamine is featured in after-sun lotions, contributing to microbial stability and skin recovery after sun exposure.
Piroctone olamine is utilized in natural deodorants as an alternative to traditional antimicrobial agents.

Piroctone olamine is added to scalp elixirs, providing a concentrated solution for targeted scalp issues.
In skincare masks designed for acne-prone skin, it helps control bacterial growth and inflammation.
Piroctone olamine is employed in facial serums to address specific microbial imbalances contributing to skin issues.

Piroctone olamine is included in tinted moisturizers, offering a combination of cosmetic coverage and skin health benefits.
Piroctone olamine is used in micellar waters, providing a gentle yet effective way to cleanse and purify the skin.
Piroctone olamine is featured in skincare capsules, offering a precise dosage for targeted treatment of skin concerns.



DESCRIPTION


Piroctone olamine is a white crystalline powder with a faint characteristic odor.
Piroctone olamine exhibits a high level of purity and is soluble in various solvents.
Piroctone olamine is often described as a biologically active compound with antifungal and antibacterial properties.

As an ethanolamine derivative, it is known for its stability under normal conditions.
Piroctone olamine is synthesized through specific chemical processes to ensure its effectiveness in personal care formulations.
Piroctone olamine plays a vital role in controlling and preventing fungal and bacterial growth in cosmetic and dermatological products.

Its molecular structure includes a pyridine ring, contributing to its pharmacological activity.
Piroctone olamine is commonly employed in skincare products due to its gentle yet effective antimicrobial action.

Piroctone olamine is characterized by its suitability for use in various formulations, including shampoos, creams, and lotions.
Piroctone olamine is recognized for its ability to address dandruff-related issues by targeting specific fungi on the scalp.

Piroctone olamine is often integrated into haircare products to promote a healthy scalp environment.
Piroctone olamine is preferred in cosmetic formulations for its compatibility with other ingredients and minimal risk of irritation.

Piroctone olamine is considered safe for topical application in recommended concentrations.
Piroctone olamine is renowned for its role in maintaining the microbial balance on the skin and scalp.
Piroctone olamine is known for its versatility, contributing to its use in various pharmaceutical and personal care applications.

It undergoes rigorous quality control measures to meet industry standards for safety and efficacy.
Piroctone olamine's stability allows for a longer shelf life in formulated products.
Piroctone olamine is often chosen for its ability to complement the activity of other active ingredients in skincare formulations.

Piroctone olamine's anti-inflammatory properties contribute to its effectiveness in soothing irritated skin conditions.
Cosmetic scientists value Piroctone olamine for its role in enhancing the overall performance of hair and skincare products.

Piroctone olamine is recognized for its role in addressing scalp concerns beyond dandruff, such as seborrheic dermatitis.
Piroctone olamine's mode of action involves disrupting the cell membranes of targeted microorganisms.

Piroctone olamine's mild nature makes it suitable for use in products designed for sensitive skin.
Piroctone olamine has gained popularity in the cosmetic industry for its contribution to the efficacy of antidandruff and antifungal formulations.
Piroctone olamine continues to be a key ingredient in the development of innovative and effective personal care solutions.



PROPERTIES


Chemical Formula: C14H27NO2
Molecular Weight: Approximately 241.37 g/mol
Physical State: White crystalline powder
Odor: Faint characteristic odor
Solubility: Soluble in ethanol and other organic solvents.
Stability: Stable under normal conditions.
Melting Point/Freezing Point: Not specifically provided.
Boiling Point and Boiling Range: Not specifically provided.
pH: Not specifically provided.
Color: White
Flash Point: Closed cup: >100°C (Not determined.)
Density: 1.04 to 1.08 g/cm³ at 20°C
Partition Coefficient (n-Octanol/Water): Not specifically provided.
Flammability: None available.
Viscosity Measurement Temperature: 25 °C
Biological Activity: Exhibits antimicrobial and anti-inflammatory properties.



FIRST AID


Inhalation:

Move the affected person to fresh air.
If respiratory irritation or difficulties persist, seek medical attention.


Skin Contact:

Remove contaminated clothing and wash the affected area thoroughly with soap and water.
If irritation occurs or persists, seek medical advice.
Contaminated clothing should be laundered before reuse.


Eye Contact:

Rinse eyes gently with water for at least 15 minutes while keeping eyelids open.
Seek medical attention if irritation persists or if any symptoms develop.


Ingestion:

If accidentally swallowed, rinse the mouth and drink plenty of water.
Do not induce vomiting unless directed by medical personnel.
Seek medical attention immediately.


General First Aid Measures:

If any adverse reaction occurs or if symptoms persist, seek medical advice.
Provide medical personnel with information about the product and its components.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment, including gloves and protective eyewear, especially when handling concentrated solutions.
Use in a well-ventilated area or provide local exhaust ventilation to control exposure levels.

Avoidance of Contact:
Minimize skin contact and avoid eye contact.
Wash hands thoroughly after handling, even if gloves are worn.

Storage:
Store Piroctone Olamine in a cool, dry place away from direct sunlight.
Keep containers tightly closed to prevent contamination and moisture absorption.

Incompatibilities:
Avoid contact with incompatible materials. Ensure compatibility with other ingredients in formulations.
Do not mix Piroctone Olamine with strong acids or bases without proper guidance.

Spill and Leak Procedures:
In the event of a spill, absorb the material with inert absorbent material.
Clean the area thoroughly to prevent slips and falls.
Dispose of waste according to local regulations.


Storage:

Temperature:
Store at ambient temperatures.
Avoid exposure to extreme heat or cold.

Container Compatibility:
Use containers made of materials compatible with Piroctone Olamine.
Ensure containers are tightly sealed to prevent moisture absorption.

Separation:
If the product is a liquid and tends to separate upon storage, gently mix or shake the container before use.

Product Integrity:
Regularly check the integrity of containers for any signs of damage or leakage.
Dispose of damaged containers appropriately.

Specific Storage Requirements:
Follow any specific storage recommendations provided by the manufacturer or supplier.
Store away from incompatible materials and substances.


Transportation:

Packaging:
Transport Piroctone Olamine in accordance with local and international regulations.
Ensure proper packaging to prevent spills or leaks during transportation.

Labeling:
Clearly label containers with product information and any hazard warnings in accordance with regulations.
PIROCTONE OLAMINE
Piroctone olamine is a preservative that is also used in anti-dandruff shampoos for anti-fungal functions.
Piroctone olamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.
Piroctone olamine has anti-fungal properties and appears as a crystalline powder in raw form that is white or slightly yellow in color.

CAS Number: 68890-66-4
EC Number: 272-574-2
Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.42

Piroctone olamine is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Piroctone olamine is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione.
Piroctone olamine is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.

Piroctone olamine is a preservative that is also used in anti-dandruff shampoos for Piroctone olamine anti-fungal functions.

Pyrithione zinc, also known as Piroctone olamine, was developed as a solution to the problem of seborrheic dermatitis, that is, dandruff, and has antibacterial, antimicrobial and antifungal properties that can help treat scalp psoriasis and acne.
The mentioned properties can destroy fungi, bacteria and microorganisms that can cause itchy complaints in the hair and scalp and cause the scalp to become flaky.

Piroctone olamine has the potential to have antifungal effects to prevent or treat fungal infections.
Piroctone olamine helps reduce inflammation in the skin.

Piroctone olamine provides antioxidant effect by protecting the skin from the harmful effects of free radicals.
Piroctone olamine shows cleansing potential to remove dirt, oil and debris.
Piroctone olamine can help eliminate bad odors.

Piroctone olamine is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
Piroctone olamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.

Piroctone olamine is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Shampoos with Piroctone olamine are very effective in curing dandruff and preventing hair loss.

Piroctone olamine has anti-fungal properties and appears as a crystalline powder in Piroctone olamine raw form that is white or slightly yellow in color.
Further, Piroctone olamine is slightly soluble in oil and water.
The chemical formula of Piroctone olamine is C14H23NO2.C2H7NO.

Piroctone olamine has a petrochemical origin.
Piroctone olamine is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.
Typically, Piroctone olamine is an alternative to the commonly used compound zinc pyrithione.

Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing Piroctone olamine are effective in treating various kinds of hair problems.

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Piroctone olamine is a pyridone derivative, which is known to have bactericidal effects on gram-positive and gram-negative bacteria and fungicidal effects and hence is a component of many cosmetic products such as anti-dandruff shampoo.

Piroctone olamine, also called Octopirox, is an antifungal of the hydroxy-pyridone family unrelated to other antiseptics used in veterinary medicine.
Members of the “pirox” family are currently used in the human field as topicals to cure onychomycosis and Malassezia-related skin disorders.

Piroctone olamine has broad in vitro activity against major dermal veterinary pathogens, including dermatophytes and yeasts as well as some Gram positive (Staphylococcus) and Gram negative (Pseudomonas) bacteria.
As opposed to azole derivatives, PO remains fully active on resting fungal cells; Piroctone olamine antiseptic activity proceeds from inhibition of the respiratory chain in yeast mitochondria.

No resistance to PO has been documented to date.
In addition, this antiseptic acts at low concentrations, has high affinity for keratin and is completely safe.
Incorporation of PO in Allermyl therefore aims at controlling microbial proliferation associated with allergic disease.

Piroctone olamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Piroctone olamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Piroctone olamine is known for many years as a successor to Ketoconazole as an excellent anti-dandruff agent.
More recently Piroctone olamine has been discovered that Piroctone olamine has a much broader protection range against all kinds of microbiological species.

Is also being used in many preservative formulations at neutral pH, which is important for sunscreen formulations.

Piroctone olamine is slightly soluble in both water and oil.
Freely soluble in 10% ethanol in water.

Soluble in solutions containing surfactants in water or in 1-10% ethanol.
The solubility of Piroctone olamine in water varies by pH value.
This is a little larger in neutral or weak basic solutions than in acid solutions.

Typical use level is only 0.05 – 0.2%.

Piroctone olamine is a hydroxamic acid that inhibits ergosterol synthesis, the main component of the cell wall of most fungi.
Piroctone olamine is used as a cream or shampoo at a 0.5–1% concentration.

Piroctone olamine alone or in combination with other agents has been demonstrated to reduce erythema, scaling, burning/stinging sensation, and pruritus in patients with FSD, with excellent cosmetic results.
Piroctone olamine is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Designed specifically to treat seborrheic dermatitis and dry scalp, Piroctone olamine offers additional benefits: Piroctone olamine is environmentally friendly, multifunctional (doubles as preserving agent), and flexible for various cosmetic formats.
Piroctone olamine is compatible with most surfactants, additives and active ingredients used in cosmetic formulations.

Piroctone olamine is an effective, practically nontoxic antidandruff active ingredient.
Piroctone olamine is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine is a highly effective antidandruff agent and an anti-acne active agent.
Piroctone olamine is antimicrobial, soluble in surfactant systems.
Piroctone olamine is used shampoos, shower products, liquid soaps, hair conditioners, hair styling products, antiperspirant & deodorants.

Piroctone olamine, despite the recent upsurge in usage, has historically not been a hugely popular ingredient.
So very few independent clinical studies have been performed.
Piroctone olamine main advantage is that it’s well tolerated, and so can be used frequently to control mild dandruff, but this hasn’t been properly evaluated.

Piroctone olamine is one of the more recent active ingredients found in dandruff shampoos.
Designed to treat seborrheic dermatitis and dry scalp Piroctone olamine is one of the most innovative areas of dandruff treatment on the market today.

Dandruff and seborrheic dermatitis can cause hair loss and thinning hair.
Piroctone olamine is assumed that dandruff and seborrheic dermatitis (dandruff is a form of seborrheic dermatitis) are caused by a yeast (single cell fungus) on the skin, the Malassezia globose.
This is a fungus that occurs only on the scalp.

Often times, the problem will not go away on Piroctone olamine own and requires continues treatment.
A well-known agent for this is shampoo with Ketoconazole in high concentration.
Multiple studies about the effectiveness of Piroctone olamine have shown that Piroctone olamine stimulates hair growth and helps against hereditary hair loss.

Ketoconazole is most well-known, but Piroctone olamine is not the only proven anti-dandruff ingredient in shampoos which stimulates hair growth.
Piroctone olamine has a similar effect as Ketoconazole.

Piroctone olamine is also listed under the brand name 'Octopirox'.
In a study with 150 men who suffer from hereditary hair loss and dandruff, Ketoconazole and Piroctone olamine were compared.

Excessive secretion of sebum, dandruff and seborrheic dermatitis are often linked with hair loss and hereditary hair loss.
The 150 men received a shampoo with 1% Ketoconazole or 1% Piroctone olamine.
They had to use this shampoo 2 to 3 times per week for a duration of six months.

All treatments showed a reduction in itching and dandruff after 2 to 6 weeks.

If we take a look at the effect of the treatments on various hair growth parameters, we see the following figures (in percentages):
The severity of hair loss decreases (Ketoconazole: -17.3%, Piroctone olamine: -16.5%)

The percentage of hairs in the growth phase increases (Ketoconazole 4.9%, Piroctone olamine: 7.9%)
The effect on the hair diameter is increased by 5.4% with Ketoconazole and by 7.7% with Piroctone olamine.

Thus, the study shows that Piroctone olamine scores better in a number of areas in comparison to Ketoconazole.

Compared to Ketoconazole, Piroctone olamine ensures an increase in the number of hairs in the growth phase (anagen phase) by more than 10% in 33% of people.
Piroctone olamine gives 88% of the people thicker hair, despite hereditary hair loss, whereby this is 78% with Ketoconazole.
If we take a look at how many people experience a significant increase (more than 10%) of the hair diameter, this is 28% with Ketoconazole and as much as 34% with Piroctone olamine (10% larger diameter means that the hair became 20% heavier).

The above results show that both Ketoconazole and Piroctone olamine have a positive effect on multiple aspects of hair growth.
They have a similar effect on itch and dandruff.
Piroctone olamine generally scores better when Piroctone olamine comes to hair growth.

Piroctone olamine is a preservative also used for Piroctone olamine antifungal functions in anti-dandruff shampoos.
Piroctone olamine is forbidden in organic.

Restriction in Europe:
Maximum concentration in ready-to-use preparation

Maximum content of secondary amine: 0.5%

Other restrictions:
Do not use with nitrosating systems
Minimum purity: 99%
Maximum content of secondary amine: 0.5% (applies to raw materials)
Maximum nitrosamine content: 50 micrograms / kg
Keep in containers without nitrite

If used as a conservator:

The maximum concentration allowed in ready-to-use cosmetic preparations is:
1.0% in Piroctone olamines to be rinsed
0,5% in other products

Applications of Piroctone olamine:
Piroctone olamine is quite beneficial in maintaining cosmetic and personal care products.
Piroctone olamine can commonly be found in products like shampoos, cleansers, and hair masks.

Skin care:
Piroctone olamine can be used to eliminate the bad odor from the surface of the skin.
Piroctone olamine is a great preservative that helps in keeping skin care products free from bacterial growth.

Hair care:
Piroctone olamine is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone olamine is also good for preventing hair loss and split ends.

Cosmetic products:
In cosmetic products, Piroctone olamine makes use of Piroctone olamine antifungal properties to keep Piroctone olamines free from unwanted bacterial growth for a longer time.
The addition of Piroctone olamine improves the quality of Piroctone olamines and makes them last longer.

Uses of Piroctone olamine:
Piroctone olamine is a broad-spectrum microbiocide/microbiostat, may be used in formulating antidandruff shampoo, hair keep and hair care, soap, etc.

Piroctone olamine is used in shampoo, hair care, bath liquid, cosmetics, skin care products and washing products.
Piroctone olamine has a unique effect in relieving skin itching, with excellent anti-itch effect, can effectively kill fungi on the skin, and has a special effect in eliminating body odor.
Piroctone olamine is a safe, non-toxic, non-stimulating, ideally effective fungicide.

Piroctone olamine anti-dandruff and anti-itch effect is superior to similar products.
Excellent solubility and compound performance, no precipitation or stratification when mixed with cosmetic raw materials.
Unique anti-dandruff mechanism, very low irritation, no hair loss, no hair breakage, safety is better than similar anti-dandruff anti-itch products.

Suggested use:
One in every three persons suffers from a problem related to their hair.
Whether Piroctone olamine is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.

And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.

The most effective are not usually the ones which are famous (as anything can become famous if Piroctone olamine is marketed and advertised well), they are the ones that have the appropriate ingredients.
Piroctone olamine is the answer to that question.

Rate of Application:
Antidandruff hair keep: 0.1-0.8% active ingredient.
Antidandruff fixing agent: 0.05-0.2% active ingredient.
Antidandruff hair emulsion: 0.1-0.3% active ingredient.
Antidandruff hair supporting: 0.05-0.1% active ingredient.
Preservative: 0.2-0.5% active ingredient
Smell-eliminating agent: 0.2-0.5% active ingredient
Smell-eliminating scented soap: 0.2-0.5% active ingredient.

Consumer Uses:
Piroctone olamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Other release to the environment of Piroctone olamine is likely to occur from: indoor use as processing aid.

Widespread uses by professional workers:
Piroctone olamine is used in the following products: cosmetics and personal care products.
Piroctone olamine is used for the manufacture of: chemicals.
Other release to the environment of Piroctone olamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Uses at industrial sites:
Piroctone olamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Piroctone olamine is used for the manufacture of: chemicals.
Release to the environment of Piroctone olamine can occur from industrial use: in processing aids at industrial sites and in the production of articles.

Benefits of Piroctone olamine:
Piroctone olamine has been specially developed to solve dandruff problems.
Piroctone olamine prevents the scalp from flaking.

Piroctone olamine contributes to the purification of hair roots from bacteria and fungi.
Piroctone olamine is effective in eliminating the factors that cause itching at the roots of the hair.
Piroctone olamine helps purify and cleanse the hair and scalp.

Shampoos, which have Piroctone olamine as one of their ingredients, are known to eliminate dandruff.
However, before we learn how they cure dandruff, we must know what causes dandruff in the first place.

Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations.
Often all these together cause dandruff.

Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.
Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.

This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.
The reason why shampoos with Piroctone olamine can reduce and eliminate dandruff is that Piroctone olamine is known to kill the fungus or the fungal infections that irritate the scalp.

Moreover, Piroctone olamine is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone olamine is considered a great ingredient in shampoos.

Cures Dandruff:
Malassezia Globosa is not a friendly fungus found in your scalp.
Piroctone olamine is the main reason behind scalp issues like dandruff and seborrheic dermatitis.

Your scalp becomes irritated and starts shedding tiny flakes.
In severe cases, you will notice inflammation, redness, and extremely itchy patches.
If you want to prevent your scalp from worsening, it’s essential to control the situation promptly.

Piroctone olamine has antifungal properties, which will help you control the spread of Malassezia globosa.
Use an anti-dandruff shampoo containing Piroctone olamine to fight dandruff.

Prevents Hair Loss:
Regardless of your gender and age, you may face hair fall, mostly caused due to dirt, dust, pollution, dandruff, excessive use of hair styling tools, etc.
Dandruff makes your scalp itchy, which leads to constant scratching, redness, and hair follicle damage.

Even though hair fall due to dandruff is not a significant concern but in people with androgenic alopecia (a condition that leads to baldness), Piroctone olamine is a proven cure for reducing hair fall.
As Piroctone olamine effectively works on dandruff and fungal infections, naturally, your hair loss decreases over time.

Boosts Hair Growth:
Piroctone olamine encourages hair growth in many ways.
Piroctone olamine reduces hair fall and increases the hair diameter.
Piroctone olamine is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone olamine provides better results for dandruff and fungal infections.

Ketoconazole + Piroctone olamine is a combination of two antifungal medicines:
Ketoconazole and Piroctone olamine which treat dandruff.

Ketoconazole kills fungi by destroying the fungal cell membrane.
Piroctone olamine works by penetrating the cell membrane of the fungi to interfere with their energy metabolism and oxygen uptake.
This kills the fungi and clears up the infection.

Functions of Piroctone olamine:

Preservative:
Inhibits the development of microorganisms in cosmetic products.

Anti dandruff:
Helps fight against dandruff.
Piroctone olamine is an active, dandruff-fighting ingredient used in some of our shampoos.

Characteristics of Piroctone olamine:
Piroctone olamine is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp.
Piroctone olamine also reduced sebum production.

Appearance of Piroctone olamine:
Piroctone olamine has a white crystalline powder structure.

Resolution
Piroctone olamine has low solubility in water.
Piroctone olamine dissolves better in some organic compounds.

Solubility of Piroctone olamine:
The solubility of Piroctone olamine is greatly dependent on the pH.
Generally speaking, Piroctone olamine solubility in aqueous formulations is greater in the neutral and weakly alkaline ranges than in the acid range (formation of free acid).
Piroctone olamine does however have adequate solubility in the usual pH range (pH5 - 8) in commercial surfactant solutions and alcohol-water mixtures.

Extraction method of Piroctone olamine:
Piroctone olamine is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone olamine is a compound, which is often used to cure fungal infections.
Piroctone olamine is a hydroxamic acid derivative Piroctone.

Origin of Piroctone olamine:
Piroctone olamine is of petrochemical origin and helps treat dandruff.
There is no natural alternative that comes close to being as effective as this.

History of Piroctone olamine:
Piroctone olamine has been used for around 40 years, first developed by Schwarzkopf-Henkel for use in anti-dandruff shampoo in the late 1970s.
All the initial clinical and safety studies were conducted by Hoechst AG, but this changed in the mid-1990s when other cosmetics companies began using the ingredient.

Piroctone olamine was first submitted for approval to the European Union and United States FDA in the 1980s.
The ingredient was first approved for addition to the United States Pharmacopeia (USP) in 2008, after the FDA sought additional safety and effectiveness data in 2004.

Handling and storage of Piroctone olamine:

Advice on safe handling:
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.

Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.

Storage stability:

Recommended storage temperature: 2 - 8 °C

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and reactivity of Piroctone olamine:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

Incompatible materials:
Strong acids and oxidizing agents, Strong oxidizing agents

Health Effect of Piroctone olamine:
If used as a preservative, Piroctone olamine should be used at a maximum rate of 1.0% in rinsed products and at a maximum rate of 0.5% in other products.
Piroctone olamine should not be used together with nitrosamine-forming agents.

Nitrosamines are carcinogenic substances.
The impurity rate should be 99%.

The maximum amount of secondary amine should be 0.5%.
The maximum amount of nitrosamine cannot exceed 50 micrograms/kg. The raw material should be stored in nitrite-free packaging.

Piroctone olamine is a synthetic component.
They are raw materials produced using various processes under laboratory conditions.

These are raw materials obtained without using animal sources (propolis, honey, beeswax, lanolin, collagen, snail extract, milk, etc.).
Piroctone olamine is a criterion that should be taken into consideration for those who want to use vegan products.

Studies have concluded that different effects can be seen on each skin type.
For this reason, the allergy/irritation effect may vary from person to person.
However, Piroctone olamine causes stinging, tingling, itching, redness and irritation, especially in people with sensitive skin types.

Precaution of Piroctone olamine:
However, just like excess of anything is bad, too much of Piroctone olamine can be bad for the scalp too.
This is precisely why shampoos with Piroctone olamine have a very minor amount of Piroctone olamine so that its side effects do not affect the scalp in any way.

Piroctone olamine should be kept in mind that shampoos with Piroctone olamine should not be used more than twice a week, unlike other daily use shampoos that don’t have this ingredient.
One of the biggest side effects of Piroctone olamine is that it can cause irritation and itchiness on the head.

First aid measures of Piroctone olamine:

General advice:
Consult a physician.

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.

In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures of Piroctone olamine:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from Piroctone olamine:
Carbon oxides
Nitrogen oxides (NOx)

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

Further information:
No data available

Accidental release measures of Piroctone olamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid dust formation.

Avoid breathing vapors, mist orgas.
Ensure adequate ventilation.

Evacuate personnel to safe areas.
Avoid breathing dust.

Environmental precautions of Piroctone olamine:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Identifiers of Piroctone olamine:
CAS Number: 68890-66-4
ChemSpider: 45574
ECHA InfoCard: 100.065.957
MeSH: Piroctone+olamine
PubChem CID: 50258
UNII: A4V5C6R9FB
CompTox Dashboard (EPA): DTXSID4046735
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYAP
SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

CAS NO: 68890-66-4
EC NO: 272-574-2

Synonym(s): 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
CAS Number: 68890-66-4
Molecular Weight: 298.42
EC Number: 272-574-2
MDL number: MFCD01690792
PubChem Substance ID: 329757760
NACRES: NA.24

Product Number: P2178
Purity / Analysis Method: >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight: C14H23NO2·C2H7NO = 298.43
Physical State (20 deg.C): Solid
Storage Temperature: 0-10°C
Condition to Avoid: Heat Sensitive
CAS No: 68890-66-4
Related CAS No: 50650-76-5
Reaxys Registry Number: 7503297
PubChem Substance ID: 253662076
Merck Index (14): 7502
MDL Number: MFCD01690792

Properties of Piroctone olamine:
Chemical formula: C16H30N2O3
Molar mass: 298.421

Molecular weight: 298.43
Formula: C14H23NO2·C2H7NO
Purity: >97.0%(T)(HPLC)
Color/Form: White to Almost white powder to crystal
MDL: MFCD01690792
Melting point: 136 °C
Flash point: 136 °C
HS code: 2933790090

grade: analytical standard
Quality Level: 100
Assay: ≥99.0% (HPLC)
shelf life: limited shelf life, expiry date on the label

technique(s)
HPLC: suitable
gas chromatography (GC): suitable

application(s):
agriculture
environmental

format: neat
storage temp.: 2-8°C
SMILES string: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C
InChI: 1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChI key: BTSZTGGZJQFALU-UHFFFAOYSA-N

Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 298.22564282 g/mol
Monoisotopic Mass: 298.22564282 g/mol
Topological Polar Surface Area: 86.8Ų
Heavy Atom Count: 21
Complexity: 371
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Specification of Piroctone olamine:
Appearance: White or slightly yellow crystalline powder
Odor: Characteristic

Solubility:
Water (0.10g +10ml):non-soluble
Methanol (1.00g + 10ml): soluble

Purity(HPLC) %: ≥99.0
PH value(1% aqueous suspension,20℃): 8.5-10.0
Melting Point ℃: 130-135
Drying loss %: ≤0.3
Ash(SO4) %: ≤0.2
Particle size distribution: D(0.5): 30-50um Provide a profile representative of the raw material
E1% (1cm) at 317 nm expressed an dried substance: 214-236
Ethanolamine %: 20.0-21.0
Nitrosamine content PPB: ≤50
Heavy metals(Pb,As,Cd,Co,Cr,Hg,Ni,Sb) PPM: ≤10
Hexane(GC) PPM: ≤300
Ethyl acetate(GC) PPM: ≤5000

Names of Piroctone olamine:

Regulatory process names:
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon, monoethanolamine salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1)
Kopirox
Octopirox
Piroctone ethanolamine salt
Piroctone olamine

IUPAC names:
(RS)-1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2(1H)-PYRIDINONE ETHANOLAMINE (1:1)
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpently)pyridin-2-(1H)-one compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one,compound with 2-aminoethanol (1:1)
1-hydroxy-4methyl-6-(2,4,4-trimethylphenyl)pyridine-2(1H)-one, compound with 2-aminoethanol(1:1)
2-aminoethanol; 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-amminoetanolo; 1-idrossi-4-metil-6-(2,4,4-trimethylpentyl) pyridin-2-one
Octopirox
Piroctone Olamine
Piroctone Olamine
Piroctone olamine

Trade names:
Picroctone Olamine
Piroctone olamine

Other identifier:
68890-66-4

Synonyms of Piroctone olamine:
PIROCTONE OLAMINE
68890-66-4
Octopirox
Piroctone ethanolamine
Kopirox
Piroctoneolamine
Octopyrox
Piroctone ethanolamine salt
Piroctone olamine [USAN]
C14H23NO2.C2H7NO
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
EINECS 272-574-2
UNII-A4V5C6R9FB
A4V5C6R9FB
NSC-759894
PIROCTONE ETHANOLAMINE SALT (1:1)
Piroctone olamine (USAN)
EC 272-574-2
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)
Octopirox (TN)
SCHEMBL2843
CHEMBL2107154
PIROCTONE OLAMINE [INCI]
PIROCTONE OLAMINE [MART.]
PIROCTONE OLAMINE [USP-RS]
AMY40819
BCP29912
HY-B1345
MFCD01690792
s5213
Piroctone olamine, analytical standard
AKOS025149526
CCG-267454
CS-7659
NSC 759894
PIROCTONE ETHANOLAMINE [WHO-DD]
AS-15254
C14-H23-N-O2.C2-H7-N-O
LS-133057
FT-0653357
P2178
D05505
Piroctone ethanolamine salt; Octopirox; Kopirox
PIROCTONE ETHANOLAMINE SALT (1:1) [MI]
A836281
Q412572
W-104652
4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine
Piroctone olamine, United States Pharmacopeia (USP) Reference Standard
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt
1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-
1- hydroxy- 4- methyl- 6- (2, 4, 4- trimethylpentyl)pyridin- 2(1H)- one, compound with 2- aminoethanol (1:1)
Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon --2-aminoethanol (1:1) [German] [ACD/IUPAC Name]
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1) [ACD/IUPAC Name]
1-Hydroxy-4-méthyl-6-(2,4,4-triméthylpentyl)-2(1H)-pyridinone - 2-aminoéthanol (1:1) [French] [ACD/IUPAC Name]
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-Aminoethanol Salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1) [ACD/Index Name]
272-574-2 [EINECS]
68890-66-4 [RN]
A4V5C6R9FB
MFCD01690792
octopirox [Trade name]
Piroctone ethanolamine
Piroctone ethanolamine salt
Piroctone olamine [Wiki]
UNII:A4V5C6R9FB
[68890-66-4] [RN]
1-Aminoethane
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanol ammonium salt
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
2-aminoethanol and 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-hydroxyethylammonium; 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone
Octopirox| Piroctone ethanolamine
Piroctone
Piroctone olamin
PIROCTONE OLEAMINE
QA-6124
PIROCTONE OLAMINE
Piroctone Olamine is an amine salt.
Piroctone Olamine has a white crystalline powder structure.
Piroctone Olamine has low solubility in water.


CAS Number: 68890-66-4
EC Number: 272-574-2
Chem/IUPAC Name: 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
Molecular Formula: C16H30N2O3



SYNONYMS:
Piroctone Olamine, 68890-66-4, Octopirox, Kopirox, Piroctone Ethanolamine, Octopyrox, Piroctoneolamine, Piroctone Ethanolamine Salt, Piroctone Olamine [USAN], UNII-A4V5C6R9FB, EINECS 272-574-2, A4V5C6R9FB, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, NSC-759894, Piroctone Ethanolamine Salt (1:1), EC 272-574-2, NSC 759894, Piroctone Olamine (USAN), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, PIROCTONE OLAMINE (MART.), PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE (USP-RS), PIROCTONE OLAMINE [USP-RS], 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, DTXCID2026735, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Allermyl, Keratolux, Octopirox (TN), SCHEMBL2843, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), CHEMBL2107154, BTSZTGGZJQFALU-UHFFFAOYSA-N, AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone Olamine, Analytical Standard, AKOS025149526, CCG-267454, CS-7659, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, P2178, D05505, Piroctone Ethanolamine Salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone Olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt, EcoGard, POOctopirox, Piroctone Olamine, Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, Octopirox, Octopyrox, Piroctone Ethanolamine Salt, Piroctone Olamine



Piroctone Olamine is an anti-dandruff product that works very effectively as antimicrobial, anti-odor and anti-acne, with a usage rate of maximum 1% for rinsed products and maximum 0.5% for non-rinsed products.
Effectively eliminates unpleasant odors in both humans and pets.


Piroctone Olamine reduces sebum outflow on the skin surface and is suitable for anti-acne application.
Piroctone Olamine is a clinically approved, effective, safe to use and non-irritating alternative to Zinc Pyrithione and a more successful product than Zinc Pyrithione.


Piroctone olamine has a special effect against Pityrosporum Ovale, which is responsible for the production of dandruff.
Piroctone Olamine has a white crystalline powder structure.
Piroctone Olamine has low solubility in water.


Piroctone Olamine dissolves better in some organic compounds.
Piroctone Olamine has the potential to have antifungal effects to prevent or treat fungal infections.
Piroctone Olamine helps reduce inflammation in the skin.


Piroctone Olamine provides antioxidant effect by protecting the skin from the harmful effects of free radicals.
Piroctone Olamine shows cleansing potential to remove dirt, oil and debris.
Piroctone Olamine can help eliminate bad odors.


Piroctone olamine (INN; also known as piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone was first synthesized in 1979 by Schwarzkopf-Henkel (Germany).
Piroctone Olamine is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis


Aako PO is better known as Piroctone Olamine.
Piroctone Olamine is known for many years as a successor to Ketoconazole as an excellent anti-dandruff agent.
More recently it has been discovered that Piroctone Olamine has a much broader protection range against all kinds of microbiological species.


Piroctone Olamine is slightly soluble in both water and oil.
Freely soluble in 10% ethanol in water.
Piroctone Olamine is soluble in solutions containing surfactants in water or in 1-10% ethanol.


The solubility of Piroctone Olamine in water varies by pH value.
This is a little larger in neutral or weak basic solutions than in acid solutions.
Typical use level of Piroctone Olamine is only 0.05 – 0.2%.


Piroctone Olamine is also known under the names PO.
Piroctone Olamine, (1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone,2-aminoethanol salt(1:1)) SpecKare PO is a special and widely used anti-dandruff which may be used in all kinds of hair products.


The anti-dandruff product containing Piroctone Olamine destroys the fungus infection that is responsible for the dandruff and works against the formation of new dandruff.
Piroctone Olamine makes the scalp stay clean and itch free.


Piroctone olamine is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Piroctone Olamine is a white to off-white crystalline powder with a very faint odor.


Piroctone Olamine is insoluble in water, mineral oil, and isopropylene; and soluble in ethanol and propylene glycol.
Piroctone Olamine is a remarkably effective anti-dandruff agent almost nontoxic ingredient for haircare products and clear shampoo.
Piroctone Olamine is an anti-dandruff product that works very effectively as an antimicrobial, anti-odor and anti-acne, with a maximum usage rate of 1% in rinsed products and 0.5% in non-rinsed products.


Piroctone Olamine exhibits low toxicity, low irritation, and excellent efficacy in hair care applications.
In addition, Piroctone Olamine has good pH and thermal stability, solubility in surfactant systems, and good compatibility with other ingredients.
Piroctone Olamine is the only anti-dandruff agent approved for both rinse-off & leave-on products.


In comparison with other popular anti-dandruff agents, Piroctone Olamine is the best cost-performance option.
Piroctone Olamine has a petrochemical origin.
Piroctone Olamine is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.


Typically, piroctone olamine is an alternative to the commonly used compound zinc pyrithione.
Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing piroctone olamine are effective in treating various kinds of hair problems.


Piroctone Olamine is soluble in ethanol, slightly soluble in water, which is safe, non-toxic and non-irritating.
Piroctone Olamine can destroy the fungus infection that is responsible for the dandruff and work against the formation of new dandruff, make the scalp stays clean, itch free and prevent the formation of new dandruff.


Piroctone Olamine also can eliminate unpleasent odor effectively, decrease the sebum output at the skin surface.
Piroctone Olamine has wide-spectrum of anti-bacteria and anti-fungi properties, and has an obvious action of increasing the shampoo viscosity of the salt thickening system.



USES and APPLICATIONS of PIROCTONE OLAMINE:
Enhancing Skincare: The suggestion is make to consider exploring products that contain Piroctone Olamine as an ingredient, possibly in combination with other essential oils and skincare products.
Piroctone Olamine is a versatile ingredient that uses in the formulation of products designed to address dandruff issues, control bacterial growth, and manage body odor.


Piroctone Olamine commonly finds in shampoos, hair tonics, and similar products intended for scalp and hair care.
Additionally, its thickening and preservation properties make Piroctone Olamine valuable in various cosmetic formulations.
As with any cosmetic or skincare ingredient, it’s essential to follow the manufacturer’s instructions and use products containing Piroctone Olamine as directed for best results and safety.


Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.


Piroctone Olamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.
The anti-dandruff product containing piroctone olamine eliminates the fungal infection responsible for dandruff and works against the formation of new dandruff, keeps the scalp clean, does not itch and prevents the formation of new dandruff.


Piroctone Olamine is used Shampoo, Deodorant (Pet care), Soap, Aftershave balm, anti irritation cream, anti acne cream, and hair mask.
Piroctone Olamine is used in volumizing shampoo formulas that increase hair thickness.
The usage rate of Piroctone Olamine is generally between 0.5% and 2% in hair products and 0.1% and 1% in skin care products.


Piroctone Olamine is also being used in many preservative formulations at neutral pH, which is important for sunscreen formulations.
Combined with AakoSun EHG or other preservative boosters Piroctone Olamine gives strong preservation of your cosmetic, deodorant or sunscreen formulation.
Piroctone Olamine is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione which was banned in the EU in 2021 because of concerns for environmental toxicity.


Piroctone Olamine is often used in anti-dandruff shampoo.
Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.


Piroctone Olamine is used anti-dandruff & anti-itching agent, eliminate dandruff at source by being bactericidal and antioxidant, effectively inhibit Malassezia, replace Zinc pyrithione (ZPT is a prohibition of use in Europe because it causes cancer), widely be used for shampoo, body wash ,hair-conditioner,mist spray,hair removal cream,antiperspirant deodorant etc; Broad-spectrum antibacterial properties , also can be used as a preservative in cosmetics ; Oil-control & anti-acne , used for face serum.

Products and services : Anti-microbial agents, Antioxidants.
Piroctone Olamine is used body make-up, Cleansing, shampoos, Hand / foot / nail care, Body care, Hand wash / sanitizers, Bath and shower, scrubs, Cleansers, soaps.


Piroctone olamine is a preservative also used for its antifungal functions in anti-dandruff shampoos.
Piroctone Olamine effectively eliminates unpleasant odors in both humans and pets.
Piroctone Olamine is used in shampoo formulas that increase hair thickness and add volume.


Piroctone Olamine reduces the sebum output on the skin surface and is suitable for anti-acne application.
Piroctone Olamine is a clinically approved effective, safe to use and non-irritating alternative to Zinc Pyrithione, and Zinc Pyrithione is a better successful product.


Piroctone olamine has a special effect against Pityrosporum Ovale, which is responsible for the production of dandruff.
The anti-dandruff product containing piroctone olamine destroys the fungal infection responsible for dandruff and works against the formation of new dandruff, keeps the scalp clean, does not itch and prevents the formation of new dandruff.


Thanks to its antiseptic properties, Piroctone Olamine can be used as an antimicrobial agent, deodorant, or even a preservative.
Thus, Piroctone Olamine is suitable for anti-acne preparations, antiperspirants, and various cosmetic products as a preservative with low toxicity.
Piroctone olamine acts as an anti-dandruff agent.


Piroctone Olamine is also used as a preservative and thickening agent for elimination of body offensive smell.
Piroctone Olamine is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp.


Piroctone Olamine also reduced sebum production. Piroctone Olamine is used in shampoos (non-coloring), tonics, dressings and other hair grooming aids.
Therefore Piroctone Olamine can be used in anti-dandruff shampoo, hair keep and hair care, soap and other products.
Piroctone Olamine is another active ingredient that is commonly used in hair care products to treat dandruff and other scalp conditions.


Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma
Like zinc pyrithione, Piroctone Olamine works by controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues.
Piroctone Olamine is an antifungal ingredient that is commonly used in hair care products to treat dandruff and other scalp conditions.


Piroctone Olamine is also known by its trade name, Octopirox.
Piroctone Olamine works by controlling the growth of Malassezia, a type of yeast that is commonly found on the scalp and can contribute to dandruff and other scalp issues.


Piroctone Olamine does this by disrupting the cell membrane of the yeast, which prevents it from multiplying and spreading.
In addition to its antifungal properties, Piroctone Olamine also has moisturizing properties that can help to soothe and hydrate the scalp, preventing dryness and flakiness.


Piroctone Olamine is generally considered safe for use in hair care products, and it is suitable for those with sensitive skin.
Piroctone Olamine is also safe for use on coloured hair and will not cause fading or strip color.
Overall, Piroctone Olamine is an effective ingredient for controlling dandruff and promoting a healthy scalp.



PIROCTONE OLAMINE SHAMPOO:
We use piroctone olamine (PO) in our shampoos because it’s an effective active ingredient that targets the symptoms of dandruff and its root cause – Malassezia globosa.

Unlike some other dandruff actives you may have heard of, piroctone olamine has a special chemical structure that is easy to dissolve in our shampoo formula, which means that we can design the product to give your hair extra benefits like smoothness and softness.

All this means that not only do you get the anti-dandruff properties you’d expect from Head & Shoulders shampoo, but hair that’s great looking and delightfully soft too.



SUGGESTED USE OF PIROCTONE OLAMINE:
One in every three persons suffers from a problem related to their hair.
Whether Piroctone Olamine is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.

And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.

The most effective ones are not usually the ones which are famous (as anything can become famous if it is marketed and advertised well), they are the ones that have the appropriate ingredients.
Piroctone Olamine is the answer to that question.



WHAT IS PIROCTONE OLAMINE USED FOR?
Piroctone Olamine is quite beneficial in maintaining cosmetic and personal care products.
Piroctone Olamine can commonly be found in products like shampoos, cleansers, and hair masks.


*Skin care:
Piroctone Olamine can be used to eliminate the bad odor from the surface of the skin.
Piroctone Olamine is a great preservative that helps in keeping skin care products free from bacterial growth


*Hair care:
Piroctone Olamine is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone Olamine is also good for preventing hair loss and split ends


*Cosmetic products:
In cosmetic products, Piroctone Olamine makes use of its antifungal properties to keep the products free from unwanted bacterial growth for a longer time.
The addition of Piroctone Olamine improves the quality of the products and makes them last longer



ORIGIN OF PIROCTONE OLAMINE:
Piroctone Olamine is basically an ethanolamine salt that is derived from Piroctone - which is a derivative of hydroxamic acid.
Piroctone Olamine appears as a crystalline white powder with a faint distinctive odor.



WHAT DOES PIROCTONE OLAMINE DO IN A FORMULATION?
*Antimicrobial
*Preservative



SAFETY PROFILE OF PIROCTONE OLAMINE:
Piroctone Olamine is safe for use when added under the recommended percentage usage - 0.1% for rinse-off products and 0.5% for leave-on products.
Piroctone Olamine suits all skin and hair types, however, a patch test should be performed before full application.
Lastly, Piroctone Olamine is not used in organic products because it is a chemical preservative.



ALTERNATIVES OF PIROCTONE OLAMINE:
*ZINC PYRITHIONE



HOW DOES PIROCTONE OLAMINE WORK?
Piroctone olamine has anti-fungal properties that make it ideal for controlling the root cause of dandruff, a commonly occurring fungus called Malassezia globosa.

The fungus occurs naturally on everyone’s scalp, but some people are sensitive to the chemicals it produces.
The skin becomes irritated, and the body reacts by rapidly shedding skin to try and get rid of the irritant, causing flaking.
Stopping this process is the key to stopping dandruff.



BENEFITS OF PIROCTONE OLAMINE FOR HAIR:
Piroctone Olamine is a popular ingredient in hair care products that are designed to treat dandruff and other scalp conditions.
Here are some of the benefits of using Piroctone Olamine for your hair:


*Controls dandruff:
Piroctone Olamine is effective at controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues.
By controlling the growth of this yeast, Piroctone Olamine can help to reduce or eliminate dandruff.


*Soothes the scalp:
Piroctone Olamine has moisturizing properties that can help to soothe and hydrate the scalp.
This can help to prevent dryness, flakiness, and itching, which are common symptoms of dandruff and other scalp conditions.


*Safe for coloured hair:
Piroctone Olamine is safe for use on coloured hair and will not cause fading or strip color.


*Prevents fungal growth:
Piroctone Olamine not only controls the growth of Malassezia, but it also prevents the growth of other fungi that can cause scalp problems.


*Long-lasting effect:
Piroctone Olamine has been shown to have a longer-lasting effect than some other dandruff-fighting ingredients, meaning you may be able to go longer between washes.


*Gentle on the scalp:
Piroctone Olamine is gentle on the scalp, making it suitable for those with sensitive skin.

Overall, Piroctone Olamine can be an effective ingredient for controlling dandruff and promoting a healthy scalp.
If you have persistent scalp issues that do not respond to over-the-counter treatments, it's a good idea to see a dermatologist for a proper diagnosis and treatment plan.



FUNCTIONS OF PIROCTONE OLAMINE IN COSMETIC PRODUCTS:
*ANTI-SEBORRHEIC
Piroctone Olamine prevents seborrhea and / or seborrheic dermatitis or relieves their symptoms; and / or acts against dandruff

*PRESERVATIVE
Piroctone Olamine protects cosmetic products from microbial spoilage



EXTRACTION METHOD OF PIROCTONE OLAMINE:
Piroctone Olamine is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone Olamine is a compound, which is often used to cure fungal infections.
This salt is a hydroxamic acid derivative Piroctone.



BENEFITS OF PIROCTONE OLAMINE:
Shampoos, which have Piroctone Olamine as one of their ingredients, are known to eliminate dandruff.
However, before we learn how they cure dandruff, we must know what causes dandruff in the first place.

Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations.
Often all these together cause dandruff.

Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.

Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.
This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.

The reason why shampoos with Piroctone Olamine can reduce and eliminate dandruff is that Piroctone Olamine is known to kill the fungus or the fungal infections that irritate the scalp.

Moreover, Piroctone Olamine is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone Olamine is considered a great ingredient in shampoos.



HOW DOES PIROCTONE OLAMINE WORK?
Piroctone olamine, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions.

Piroctone Olamine works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism.

Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death.
Piroctone Olamine also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.

Piroctone olamine has a broad-spectrum activity against many microorganisms, making it a valuable ingredient in cosmetic and personal care products.
Piroctone Olamine is also considered safe for use, with low toxicity and irritation potential, making it suitable for use on sensitive skin.



BENEFITS OF PIROCTONE OLAMINE:
*Very high purity Piroctone Olamine
*Being used often because of it’s special functions such as thickening preservation and elimination of body offensive odor.



FUNCTIONS OF PIROCTONE OLAMINE:
*Anti-dandruff
*Antiseptic
*Preservative
*Anti-Seborrheic



ADVANTAGES AND BENEFITS OF PIROCTONE OLAMINE:
The use of Piroctone Olamine offers a series of advantages and benefits for personal care needs.
Piroctone Olamine has a powerful anti-inflammatory, antibacterial and antimicrobial action.

Furthermore:
Piroctone Olamine prevents hair loss
Piroctone Olamine improves scalp health
Piroctone Olamine is easily soluble in alcohol
Piroctone Olamine is soluble in aqueous solutions of surfactants



BENEFITS CLAIMS OF PIROCTONE OLAMINE:
*Anti-Dandruff,
*Anti-Fungal,
*Anti-Itching,
*Compatibility,
*Scalp Protection Effect,
*Versatility,
*Viscosity Boosting



PIROCTONE OLAMINE POWDER:
Piroctone olamine powder is ethanolamine salt of hydroxamic piroctone.
Moreover, Piroctone Olamine is a white crystalline powder, sometimes slightly yellowish, with a faint distinctive odor.
Piroctone Olamine is used for it’s anti-dandruff, anti-bacterial and also anti-odor/fungal properties.
Piroctone Olamine’s what makes anti-dandruff dermatological products effective (shampoos & hair tonics).
In addition, Piroctone Olamine eliminates offensive body odor and is a thickening preservation.



BENEFITS OF PIROCTONE OLAMINE:
*Hair conditioning, frizz control,
*Hair strength / repair, anti-split ends,
*Anti-Dandruff,
*Anti-microbial, sanitizing,
*Antioxidant



FUNCTIONS OF PIROCTONE OLAMINE:
*Anti dandruff :
Piroctone Olamine helps fight against dandruff
*Preservative :
Piroctone Olamine inhibits the development of microorganisms in cosmetic products.



BENEFITS OF PIROCTONE OLAMINE:
1. Cures Dandruff
Malassezia Globosa is not a friendly fungus found in your scalp.
It is the main reason behind scalp issues like dandruff and seborrheic dermatitis.

Your scalp becomes irritated and starts shedding tiny flakes.
In severe cases, you will notice inflammation, redness, and extremely itchy patches.

If you want to prevent your scalp from worsening, it’s essential to control the situation promptly.
Piroctone Olamine has antifungal properties, which will help you control the spread of Malassezia globosa.
Use an anti-dandruff shampoo containing piroctone olamine to fight dandruff.


2. Prevents Hair Loss
Regardless of your gender and age, you may face hair fall, mostly caused due to dirt, dust, pollution, dandruff, excessive use of hair styling tools, etc.
Dandruff makes your scalp itchy, which leads to constant scratching, redness, and hair follicle damage.

Even though hair fall due to dandruff is not a significant concern but in people with androgenic alopecia (a condition that leads to baldness), Piroctone Olamine is a proven cure for reducing hair fall.
As it effectively works on dandruff and fungal infections, naturally, your hair loss decreases over time.


3. Boosts Hair Growth
Piroctone Olamine encourages hair growth in many ways.
Piroctone Olamine reduces hair fall and increases the hair diameter.

It is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone Olamine provides better results for dandruff and fungal infections.



ORIGIN OF PIROCTONE OLAMINE:
Piroctone Olamine is of petrochemical origin and helps treat dandruff.
There is no natural alternative that comes close to being as effective as this.



PHYSICAL and CHEMICAL PROPERTIES of PIROCTONE OLAMINE:
Water Solubility: 0.351 mg/mL
logP: 3.77
logS: -2.8
pKa (Strongest Acidic): 6.87
pKa (Strongest Basic): -6.4
Physiological Charge: -1
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 40.54 Ų
Rotatable Bond Count: 5
Refractivity: 71.81 m³·mol⁻¹
Polarizability: 27.69 ų
Number of Rings: 1
Bioavailability: 1
Rule of Five: Yes

Ghose Filter: Yes
Veber's Rule: No
MDDR-like Rule: No
Physical State: Solid
Storage: Store at 4°C
Melting Point: 130-136°C
MDL Number: MFCD01690792
Molecular Weight: 298.4267 g/mol
Chemical Formula: C16H30N2O3
Assay: 95.00 to 100.00%
Food Chemicals Codex Listed: No
Boiling Point: 344.10°C at 760.00 mm Hg (estimated)
Vapor Pressure: 0.000004 mmHg at 25.00°C (estimated)

Flash Point: 323.00°F TCC (161.90°C) (estimated)
logP (o/w): 3.696 (estimated)
Soluble in: water, 18.75 mg/L at 25°C (estimated)
Boiling Point: 344.1°C
Melting Point: 130-135°C
pH: 8.5-10.0
Solubility: Slightly soluble in water
Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Topological Polar Surface Area: 86.8Ų
Physical State: Powder
Color: White
Odor: Weak

Melting Point/Freezing Point: 132°C at 1.013 hPa
Initial Boiling Point and Boiling Range: 130-135°C (ECHA)
Flash Point: 161.9°C Pensky-Martens closed cup
Autoignition Temperature: >430°C at 1.013 hPa
pH: 8.5 at 25°C (saturated solution)
Water Solubility: Approximately 0.0298 g/l at 20°C - slightly soluble
Partition Coefficient (n-Octanol/Water): Log Pow: 3.86 at 20.5°C
Vapor Pressure: Density: 1.1 g/cm³ at 21.5°C
Relative Density: 1.1 at 21.5°C
Chemical Name: Piroctone ethanolamine
CAS No.: 68890-66-4
EINECS No.: 272-574-2

Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.4 g/mol
Appearance: White or slightly yellow crystalline powder
Purity (HPLC): ≥99.0%
PH Value (1% aqueous suspension, 20°C): 9.0-10.0
Melting Point (ºC): 133-136°C
Weight Average: 298.427
Monoisotopic: 298.225642834
Chemical Formula: C16H30N2O3
InChI Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
IUPAC Name: 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
SMILES: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C



FIRST AID MEASURES of PIROCTONE OLAMINE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PIROCTONE OLAMINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of PIROCTONE OLAMINE:
Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system



EXPOSURE CONTROLS/PERSONAL PROTECTION of PIROCTONE OLAMINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PIROCTONE OLAMINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions.
Tightly closed.
Dry.
Storage class



STABILITY and REACTIVITY of PIROCTONE OLAMINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .


PIROCTONE OLAMINE COSMETIC GRADE
Piroctone olamine cosmetic grade is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Piroctone olamine cosmetic grade is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone olamine cosmetic grade is a compound, which is often used to cure fungal infections.

CAS Number: 68890-66-4
Molecular Formula: C16H30N2O3
Molecular Weight: 298.43
EINECS Number: 272-574-2

PIROCTONE OLAMINE, 68890-66-4, Octopirox, Piroctone ethanolamine, Kopirox, Octopyrox, Piroctoneolamine, Piroctone ethanolamine salt, Piroctone olamine [USAN], UNII-A4V5C6R9FB, EINECS 272-574-2, A4V5C6R9FB, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, NSC-759894, PIROCTONE ETHANOLAMINE SALT (1:1), EC 272-574-2, NSC 759894, Piroctone olamine (USAN), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, PIROCTONE OLAMINE (MART.), PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE (USP-RS), PIROCTONE OLAMINE [USP-RS], 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, DTXCID2026735, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Allermyl, Keratolux, Octopirox (TN), SCHEMBL2843, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), CHEMBL2107154, PIROCTONE OLAMINE [INCI], AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone olamine, analytical standard, AKOS025149526, CCG-267454, CS-7659, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, FT-0653357, P2178, D05505, Piroctone ethanolamine salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine

Piroctone olamine cosmetic grade belongs to the class of hydroxypyridone antimycotics.
Shampoos with Piroctone Olamine are very effective in curing dandruff and preventing hair loss.
This ingredient has anti-fungal properties and appears as a crystalline powder in its raw form that is white or slightly yellow in color.

Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Further, Piroctone olamine cosmetic grade is slightly soluble in oil and water.
The chemical formula of Piroctone olamine cosmetic gradee is C16H30N2O3.

Piroctone olamine cosmetic grade is an antifungal and antibacterial agent that is commonly used in cosmetic and personal care products.
This salt is a hydroxamic acid derivative Piroctone.

One in every three persons suffers from a problem related to their hair.
Piroctone olamine cosmetic grade is a pyridone derivative, which is known to have bactericidal effects on gram-positive and gram-negative bacteria and fungicidal effects and hence is a component of many cosmetic products such as anti-dandruff shampoo.

Piroctone olamine cosmetic grade is structurally similar to Ciclopirox and Pyrithione.
Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative Octopirox.

Piroctone olamine cosmetic grade produced at Gujarat based facility has bacteriostatic and fungistatic properties.
A target of this product is Pityrosporumovale, which is present on the skin and causes dandruff, as well as flaking on the face and scalp.
Piroctone olamine cosmetic grade replaces Zinc Pyrithione in shampoos.

Piroctone olamine cosmetic grade a preservative and thickening agent, it is used in all types of personal care products.
Piroctone olamine cosmetic grade offered by COSROMA is called Cosroma OCT.
Piroctone olamine cosmetic grade, which is an ethanolamine salt of pyrrolidone hydroxamic acid derivative.

Piroctone olamine cosmetic grade is famous for its bacteriostatic effect, especially for inhibiting Plasmodium ovale parasitism in dandruff, face, and other dandruff.
Piroctone olamine cosmetic grade is usually used in shampoo instead of ZPT.
Piroctone olamine cosmetic grade has been used in personal care products for more than 30 years, as well as preservatives and thickeners.

In a controlled clinical trial, the results showed that Piroctone olamine cosmetic grade was superior to ketoconazole and pyridine-thione zinc in the treatment of androgen-induced hair loss by improving hair core; At the same time, Piroctone Olamine can reduce oil secretion.
Piroctone olamine cosmetic grade is a white to off-white crystalline powder with a very faint odor.
Piroctone olamine cosmetic grade is insoluble in water, mineral oil, and isopropylene; and soluble in ethanol and propylene glycol.

Piroctone olamine cosmetic grade is a remarkably effective anti-dandruff agent almost nontoxic ingredient for haircare products and clear shampoo.
Piroctone olamine cosmetic grade is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.
Piroctone olamine cosmetic grade is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products.

Piroctone olamine cosmetic grade exhibits low toxicity, low irritation, and excellent efficacy in hair care applications.
In addition, Piroctone olamine cosmetic grade has good pH and thermal stability, solubility in surfactant systems, and good compatibility with other ingredients.
Piroctone olamine cosmetic grade is one of the most efficient anti-dandruff actives available on the market today.

Designed specifically to treat seborrheic dermatitis and dry scalp, Piroctone olamine cosmetic grade offers additional benefits: it is environmentally friendly, multifunctional (doubles as preserving agent), and can be used in various cosmetic formats.
Piroctone olamine cosmetic grade is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products such as shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade is extremely easy to formulate, enabling stable formulations with no effort.
Piroctone olamine cosmetic grade controls the growth of microorganisms effectively and is directly targeting the cause of dandruff.
Piroctone olamine cosmetic grade is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade is one of the most efficient anti-dandruff actives available on the market today.
Designed specifically to treat seborrheic dermatitis and dry scalp, piroctone olamine offers additional benefits: it is environmentally friendly, multifunctional (doubles as preserving agent), and can be used in various cosmetic formats.
Piroctone olamine cosmetic grade is a compound sometimes used in the treatment of fungal infections.

Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Piroctone olamine cosmetic grade has a petrochemical origin. It is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.
Typically, Piroctone olamine cosmetic grade is an alternative to the commonly used compound zinc pyrithione.

Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing Piroctone olamine cosmetic grade are effective in treating various kinds of hair problems.
Microorganisms such as Malassezia Furfur produce enzymes which decompose fats into the respective fatty acids.

These and further decomposition products like lipo-peroxides irritate the scalp.
As a result, increased production of keratinocytes and increased mitosis occur which leads to desquamation and occurrence of parakeratosis.
Piroctone olamine cosmetic grade controls the growth of microorganisms effectively and is directly targeting the cause of dandruff.

Use Piroctone olamine cosmetic grade concentration can be chosen between 0.1 and 1.0%, depending on the finished product.
For leave-on products, the concentration can be lowered to 0.05 and 0.1%.
Piroctone olamine cosmetic grade is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products such as shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione.
Piroctone olamine cosmetic grade is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.
Piroctone olamine cosmetic grade is an effective, practically nontoxic antidandruff active ingredient.

Piroctone olamine cosmetic grade is a trade name for a chemical compound known as Piroctone Olamine.
Piroctone olamine cosmetic grade is an antifungal agent that is commonly used in anti-dandruff shampoos and other personal care products.
Piroctone olamine cosmetic grade and climbazole are widely used in the formulation of antidandruff shampoos, imported or produced inside country and no sideeffects have been reported yet.

There are no studies in publication that have compared the efficacy of these two substances in controlled conditions among human beings.
Herbal extracts because of some special properties such as hair fortifying and anti hair loss effects in addition to their less side effects, lower costs and being more available are also now increasingly used in shampoos.
There are few studies that have evaluated herbal extracts besides chemicals and there is no document dealing with cross reactions between them and their effects on clinical efficacy.

In this study, we aimed to compare clinical efficacy of climbazole with Piroctone olamine cosmetic grade in the treatment of dandruff and seborrheic dermatitis in shampoos with herbal extracts.
Piroctone olamine cosmetic grade is known for its ability to combat the growth of fungi, including the yeast Malassezia furfur, which is associated with dandruff and certain skin conditions.
Piroctone olamine cosmetic grade is well-known for its antibacterial effect and is often used in shampoos to replace ZPT( zinc pyrithione).

Piroctone olamine cosmetic grade has been used in personal care products for more than 30 years.
Piroctone olamine cosmetic grade is also used as a preservative and thickener.
Compared with other anti-dandruff agents, Piroctone olamine cosmetic grade has lower toxicity, excellent solubility, and compounding properties.

Piroctone olamine cosmetic grade will not cause precipitation or delamination when mixed with other cosmetic raw materials.
Piroctone olamine cosmetic grade has low irritation and will not cause hair loss.
In a controlled clinical trial, the results showed that Piroctone olamine cosmetic grade is superior to ketoconazole and zinc pyrithione, and Piroctone Olamine can reduce oil secretion.

Piroctone olamine cosmetic grade is the only anti-dandruff and antipruritic agent in the world that can be used as a Wash-Free product.
Piroctone olamine cosmetic grade is through the methods of sterilization, antibacterial, anti-oxidation, and decomposition of oxides to fundamentally block the external factors caused by dandruff, effectively eradicate dandruff, and stop itching.
Piroctone olamine cosmetic grade is primarily used in cosmetic formulations for its antimicrobial properties.

Piroctone olamine cosmetic grade helps inhibit the growth of fungi and bacteria, making it beneficial in products where preventing microbial contamination is important.
Piroctone olamine cosmetic grade is commonly found in various cosmetic and personal care products such as shampoos, conditioners, hair tonics, scalp treatments, skin creams, lotions, and other skincare formulations.
Piroctone olamine cosmetic grade is often used in anti-dandruff shampoos due to its ability to address conditions associated with dandruff and flaky scalp.

Piroctone olamine cosmetic grade helps control the growth of the yeast Malassezia, which is linked to dandruff.
Piroctone olamine cosmetic grade can be included to provide antimicrobial benefits, helping to maintain the microbial balance on the skin and prevent issues related to bacterial or fungal overgrowth.
Piroctone olamine cosmetic grade is used in products that aim to address conditions such as itching, redness, or discomfort associated with scalp issues.

Piroctone olamine cosmetic grade can act as a preservative in cosmetic formulations, contributing to the overall stability and shelf life of the product by preventing the growth of microorganisms.
Piroctone olamine cosmetic grade should comply with regulatory standards and guidelines for cosmetic ingredients.
Piroctone olamine cosmetic grade undergoes safety assessments to ensure its suitability for use in personal care products.

Piroctone olamine cosmetic grade is generally compatible with various formulations and can be used alongside other cosmetic ingredients without significant compatibility issues.
Piroctone olamine cosmetic grade is effective in a broad pH range, making it suitable for use in formulations with different acidity or alkalinity levels.
Piroctone olamine cosmetic grade is often included in cosmetic products targeting specific skin or hair concerns, and its use is often communicated to consumers as part of the product's beneficial properties.

Piroctone olamine cosmetic grade by Clariant is a highly effective anti-dandruff and antimicrobial agent.
Piroctone olamine cosmetic grade is an environmental friendly and multifunctional (doubles as a preserving agent).
Piroctone olamine cosmetic grade is an effective, nontoxic anti-dandruff active ingredient.

Piroctone olamine cosmetic grade is particularly suitable for the manufacture of anti-dandruff shampoos and hair care products such as hair tonics and cream rinses.
Microorganisms such as Malassezia furfur produce enzymes which decompose fats into their respective fatty acids.
These and other products of decomposition, such as lipo-peroxides, irritate the scalp.

As a result, mitosis and production of keratinocytes increases, leading to desquamation and parakeratosis.
Piroctone olamine cosmetic grade controls the growth of microorganisms effectively and directly targets the cause of dandruff.
Use concentration can be between 0.1 and 1.0%, depending on the finished product.

For leave-on products,the concentration can be lowered to between 0.05 and 0.1%.
Piroctone olamine cosmetic grade has low aquatic toxicity and broad-spectrum preservation.
Piroctone olamine cosmetic grade is sensitive towards UV light and might be decomposed depending on the amount of irradiation.

Piroctone olamine cosmetic grade is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative piroctone was first synthesized in 1979 by Schwarzkopf-Henkel (Germany).
Piroctone olamine cosmetic grade is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione which was banned in the EU in 2021 because of concerns for environmental toxicity.

Piroctone olamine cosmetic grade is basically an ethanolamine salt that is derived from Piroctone - which is a derivative of hydroxamic acid.
Piroctone olamine cosmetic grade appears as a crystalline white powder with a faint distinctive odor.
Piroctone olamine cosmetic grade is expressly approved and/or subject to a restriction as a result of an entry in Annex III of the EC Cosmetics Regulation after an assessment by the Scientific Committee on Consumer Safety of the EU Commission (SCCS).

Restrictions can relate eg to purity criteria, a maximum concentration or the restriction to certain product categories.
Subject to the conditions possibly imposed in Annex III, the use of this substance in cosmetic products is safe.
Piroctone olamine cosmetic grade and climbazole are widely used in the formulation of antidandruff shampoos, imported or produced inside country and no sideeffects have been reported yet.

There are no studies in publication that have compared the efficacy of these two substances in controlled conditions among human beings.
Herbal extracts because of some special properties such as hair fortifying and anti hair loss effects in addition to their less side effects, lower costs and being more available are also now increasingly used in shampoos.
There are few studies that have evaluated herbal extracts besides chemicals and there is no document dealing with cross reactions between them and their effects on clinical efficacy.

Piroctone olamine cosmetic grade is one of the more recent active ingredients found in dandruff shampoos.
Designed to treat seborrheic dermatitis and dry scalp piroctone olamine is one of the most innovative areas of dandruff treatment on the market today. W
Piroctone olamine cosmetic grade is widely available globally, and its use is not limited to specific regions.

Cosmetic manufacturers may incorporate Piroctone olamine cosmetic grade into formulations for products distributed internationally.
Piroctone olamine cosmetic grade is typically colorless and odorless, which makes it suitable for use in cosmetic products without affecting the color or fragrance of the final formulation.
Piroctone olamine cosmetic grade is often included in leave-in hair treatments, such as serums or leave-on scalp treatments, providing a prolonged exposure to its beneficial properties.

Piroctone olamine cosmetic grade may be used in various cleansing products, including facial cleansers or body washes, where its antimicrobial properties contribute to maintaining skin health during cleansing.
In addition to personal care products, Piroctone olamine cosmetic grade can be found in certain hygiene products, such as intimate washes or antibacterial cleansers.
Piroctone olamine cosmetic grade adheres to quality standards set by regulatory bodies and industry organizations to ensure consistency and safety in cosmetic formulations.

Melting point: 134.0 to 138.0 °C
Boiling point: 135-235℃[at 101 325 Pa]
Density: 1.1[at 20℃]
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
pka: 5.9-7.4[at 20 ℃]
form: neat
color: White to Off-White
Water Solubility: 400-50000mg/L at 20-25℃
Merck: 14,7502
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey: BTSZTGGZJQFALU-UHFFFAOYSA-N
SMILES: C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C
LogP: 1.05-3.86 at 20-25℃

Cosmetics often contain more than one preservative substances and these preservative systems act simultaneously against different bacteria, yeasts or moulds.
Each of these substances has been comprehensively tested and assessed for safety (individually and in combination).
Manufacturers always use only the lowest possible effective concentration in a product so that an optimum shelf life and safe application are ensured.

Piroctone olamine cosmetic grade is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.
Piroctone olamine cosmetic grade has a petrochemical origin.
Piroctone olamine cosmetic grade is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.

Typically, Piroctone olamine cosmetic grade is an alternative to the commonly used compound zinc pyrithione.
Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing piroctone olamine are effective in treating various kinds of hair problems.

Piroctone olamine cosmetic grade gives clear, transparent, pH- and temperature stable formulation.
Piroctone olamine cosmetic grade can be used together with most cationic surfactants and active ingredients.
Piroctone olamine cosmetic grade is an effective, practically nontoxic antidandruff active ingredient.

Piroctone olamine cosmetic grade is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.
Under the brand name Piroctone olamine cosmetic grade, it was used for the first time in July 1979 in the Seborin produced by Schwarzkopf & Henkel Düsseldorf (subsidiary of Hoechst).
Now-a-days, the Piroctone olamine cosmetic grade is present in many cosmetic products for the treatment of dandruff (Pityriasis simplex capillitii), like shampoos, even for dogs and cats.

Piroctone olamine cosmetic grade has fungicidal activity against all medically relevant dermatophytes, yeasts and mold fungi, due to penetration into the cell wall of yeast, fungi such as
Malassezia furfur and complexation with iron (III) ions, which results in an inhibition of the energy metabolism in the mitochondria of the fungi.
The concentrations should be between 0.1 and 1.0%, depending on the type of final product, or should be further reduced for preparations that remain on the hair or the scalp.
Minimum inhibition concentration for the most important species of fungi lies between 0.5 and 4.0 µg/ml.

In addition to the fungicidal activity, Piroctone olamine cosmetic grade also exhibits a bactericidal activity against gram-positive and gram- negative bacteria in 0.1-3.0% concentration in personal care compositions.
Moreover, in vitro model of experimental onychomycosis caused by T. rubrum pointed out a possible role of 0.5% Piroctone olamine cosmetic grade nail lacquer as a preventive tool for subjects at risk or as a curative tool in the first stage of onychomycosis
Piroctone olamine cosmetic grade is present as free acid in neutral solutions and is chemically stable over a wide pH range.

Piroctone olamine cosmetic grade is compatible with most surfactants, additives and active ingredients.
Piroctone olamine cosmetic grade is gentle on the scalp and causes no flake and itching.
Piroctone olamine cosmetic grade encourages hair growth in many ways. It reduces hair fall and increases the hair diameter.

Piroctone olamine cosmetic grade is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone olamine cosmetic grade provides better results for dandruff and fungal infections.
Piroctone olamine cosmetic grade is suitable for shampoo, conditioner, scalp tonic, cream rinse and hair styling products.
Recommended for roll-on, spray, foot deodorant cream and stick.

Piroctone olamine cosmetic grade has anti-fungal as well as anti-dandruff activity making it ideal for a range of products for dry skin.
Piroctone olamine cosmetic grade can be quickly degraded after being absorbed by the skin, it won't accumulate and has no side effects on the skin.
At the same time, the irritation of piroctone olamine is very small, study shows irritation to the skin is not significantly increased compared with the placebo shampoo.

Moreover, Piroctone olamine cosmetic grade can quickly combine with the iron ions in the water to lose its original toxicity, and cause less harm to aquatic organisms.
People in the world attach great importance to the safety of anti-dandruff agents.
Piroctone olamine cosmetic grade has the lowest toxicity index among similar anti-dandruff agents.

Piroctone olamine cosmetic grade's the only agent that could be used in leave-on products such as hair cream, hair spray, mousse, and hair dye.
Piroctone olamine cosmetic grade is generally considered mild on the skin, and it is suitable for use in products intended for sensitive or reactive skin.
In addition to its antimicrobial effects, Piroctone olamine cosmetic grade may contribute to the soothing of irritated skin or scalp, making it beneficial in formulations designed for addressing redness or inflammation.

Piroctone olamine cosmetic grade is commonly used in various hair care products beyond shampoos, such as conditioners, hair masks, and tonics, contributing to scalp health and overall hair care.
Piroctone olamine cosmetic grade can be found in leave-on products like creams and lotions, where its antimicrobial properties help maintain skin health over extended periods.
Piroctone olamine cosmetic grade is often formulated alongside other active ingredients, such as anti-inflammatory agents or moisturizers, to create comprehensive solutions for specific skincare concerns.

Dermatologists may recommend products containing Piroctone olamine cosmetic grade as part of skincare regimens for individuals with conditions like seborrheic dermatitis or psoriasis.
Some formulations containing Piroctone olamine cosmetic grade may be supported by clinical studies demonstrating their efficacy in addressing specific skin or scalp conditions.
Piroctone olamine cosmetic grade used in products intended for sale in different regions complies with the respective regulatory standards and guidelines in those regions.

Piroctone olamine cosmetic grade exhibits good stability in various cosmetic formulations, contributing to the overall efficacy and performance of the product over time.
As the cosmetic industry evolves, Piroctone olamine cosmetic grade may be part of innovative formulations that combine it with other cutting-edge ingredients to address emerging consumer preferences and trends.
Given its antimicrobial properties, the choice of packaging for products containing Piroctone olamine cosmetic grade may be influenced to ensure the product's stability and prevent contamination.

Cosmetic companies may include information about Piroctone olamine cosmetic grade in their marketing materials, educating consumers about its benefits and how it addresses specific skincare or hair care concerns.
Piroctone olamine cosmetic grade is commonly used in rinse-off products, like shampoos or body washes, where it helps cleanse the skin or scalp while providing antimicrobial benefits.
Cosmetic manufacturers may consider the sustainability aspects of Piroctone Olamine sourcing and production, aligning with the growing consumer demand for sustainable and eco-friendly ingredients.

Products containing Piroctone Olamine may cater to consumer preferences for effective yet gentle solutions, especially in formulations targeting sensitive or problematic skin.
Piroctone olamine cosmetic grade's compatibility with various formulation types allows cosmetic formulators flexibility in creating products with different textures and applications.
Piroctone olamine cosmetic grade is often included in formulations that promote holistic scalp care, addressing issues such as dandruff, itching, and maintaining a healthy scalp environment.

Some formulations with Piroctone olamine cosmetic grade may be recommended by dermatologists or skincare professionals for individuals with specific skin or scalp concerns.
Piroctone olamine cosmetic grade may work synergistically with other active ingredients, enhancing the overall efficacy of a cosmetic formulation.

Uses:
Piroctone olamine cosmetic grade is quite beneficial in maintaining cosmetic and personal care products.
Piroctone olamine cosmetic grade can commonly be found in products like shampoos, cleansers, and hair masks.
Piroctone olamine cosmetic grade can be used to eliminate the bad odor from the surface of the skin.

Piroctone olamine cosmetic grade is a great preservative that helps in keeping skin care products free from bacterial growth.
Piroctone olamine cosmetic grade is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone olamine cosmetic grade is also good for preventing hair loss and split ends.

In cosmetic products, Piroctone olamine cosmetic grade makes use of its antifungal properties to keep the products free from unwanted bacterial growth for a longer time.
The addition of Piroctone olamine cosmetic grade improves the quality of the products and makes them last longer
Piroctone olamine cosmetic grade is frequently incorporated into anti-dandruff shampoos.

Piroctone olamine cosmetic grade helps control the growth of the yeast Malassezia, which is associated with dandruff, and supports a healthy scalp.
Piroctone olamine cosmetic grade is used in various scalp treatments and tonics designed to address conditions such as itching, flaking, and redness associated with scalp issues.
Piroctone olamine cosmetic grade can be found in hair conditioners to provide both scalp and hair care benefits.

Piroctone olamine cosmetic grade is antimicrobial properties contribute to a healthy scalp, while its conditioning effects enhance the manageability of hair.
Piroctone olamine cosmetic grade is included in leave-on hair products like serums or creams, where its prolonged contact with the scalp can contribute to ongoing scalp health and comfort.
Piroctone olamine cosmetic grade is used in skincare formulations such as creams and lotions.

Piroctone olamine cosmetic grade is antimicrobial properties can help maintain skin health, and it may be included in products designed for sensitive or reactive skin.
In body washes and cleansers, Piroctone olamine cosmetic grade contributes to cleansing while providing antimicrobial benefits, making it suitable for maintaining skin hygiene.
Some facial cleansers targeted at addressing specific skin concerns, such as acne or seborrheic dermatitis, may contain Piroctone olamine cosmetic grade for its antimicrobial properties.

Piroctone olamine cosmetic grade may be found in certain hygiene products, such as intimate washes or antibacterial cleansers, where its antimicrobial effects are beneficial.
Piroctone olamine cosmetic grade is included in leave-on skincare treatments like serums or spot treatments, contributing to the overall health and balance of the skin.
Piroctone olamine cosmetic grade is used in moisturizers, contributing to the formulation's overall skin-conditioning properties.

Due to its mild and gentle nature, Piroctone olamine cosmetic grade is suitable for use in products designed for individuals with sensitive or reactive skin.
In some formulations aimed at addressing acne or blemishes, Piroctone olamine cosmetic grade's antimicrobial properties may contribute to maintaining a clearer complexion.
Piroctone olamine cosmetic grade may be included in personal care wipes to provide antimicrobial benefits and contribute to a refreshing and hygienic experience.

Piroctone olamine cosmetic grade is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone olamine cosmetic grade could induce apoptosis and possessed a significant in vivo effect against myeloma.
Piroctone olamine cosmetic grade, the ethanolamine salt is formed as a result of hydroxamic acid.

This ingredient is often used as a substitute for zinc pyrithione in anti-dandruff shampoos.
Seborrheic dermatitis and dandruff have been linked to hair shedding and hair thinning.
Based on a clinical study, it was revealed that Piroctone olamine cosmetic grade was more efficient than Ketoconazole or Zinc Pyrithione in thickening hair shafts in androgenic alopecia.

Piroctone olamine cosmetic grade reduces the production of sebum.
Piroctone olamine cosmetic grade is the ethanolamine salt of the hydroxamic acid derivative of piroctone.
Piroctone olamine cosmetic grade's anti-fungal and anti-inflammatory properties may contribute to its inclusion in formulations aimed at alleviating scalp itchiness.

Piroctone olamine cosmetic grade can be found in products designed to provide relief for individuals with itchy scalps.
Due to its mild nature, Piroctone olamine cosmetic grade is suitable for individuals with sensitive skin.
Piroctone olamine cosmetic grade is often chosen for formulations that need to address specific skin conditions without causing irritation.

Piroctone olamine cosmetic grade's mildness and efficacy make it suitable for daily use in various hair care and skincare products.
Piroctone olamine cosmetic grade can be included in formulations designed for regular use without causing excessive dryness or irritation.
Piroctone olamine cosmetic grade is sometimes used in combination with other active ingredients in hair care products.

Piroctone olamine cosmetic grade with other agents, such as anti-inflammatory or soothing ingredients, can enhance the overall performance of the formulation.
Regular use of Piroctone olamine cosmetic grade-containing shampoos and hair care products can serve as a preventive measure against dandruff, scalp irritation, and fungal growth.
Piroctone olamine cosmetic grade is often included in products that aim to maintain a healthy scalp environment.

Piroctone olamine cosmetic grade's compatibility with various cosmetic formulations contributes to the overall sensory experience of the product.
Piroctone olamine cosmetic grade is chosen for its ability to maintain the product's texture, appearance, and scent.
Piroctone olamine cosmetic grade may be incorporated into specialized scalp serums designed to address specific concerns such as dryness, flakiness, or sensitivity.

Ongoing research may explore new formulations and applications of Piroctone olamine cosmetic grade.
Clinical studies may investigate its efficacy in different contexts and conditions related to the scalp and skin.
Dermatologists may recommend products containing Piroctone olamine cosmetic grade for individuals with specific scalp conditions or concerns.

Piroctone olamine cosmetic grade is often included in dermatologist-recommended hair care regimens.
Piroctone olamine cosmetic grade is known for its versatility and compatibility with different hair types, making it a popular choice for inclusion in a wide range of hair care products.
Piroctone olamine cosmetic grade is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.

Recently was shown, that Piroctone olamine cosmetic grade could induce apoptosis and possessed a significant in vivo effect against myeloma.
Generally, the solubility of Piroctone olamine cosmetic grade is highly depending on the pH value of the solution.
As a rule of thumb, it is better dissolved in neutral and slightly alkaline aqueous solutions than in acidic solutions.

Piroctone olamine cosmetic grade is possible to dissolve between pH=5 to pH=8 in surfactant
Piroctone olamine cosmetic grade can also be used in anti-acne products such as gel, lotion and cleanser.
Piroctone olamine cosmetic grade is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone olamine cosmetic grade used for shampoos, and hair care products such as hair tonics and cream rinses.
Piroctone olamine cosmetic grade is a key ingredient in antidandruff shampoos.
Piroctone olamine cosmetic grade may be included in deodorant formulations for its antimicrobial properties, helping to control the growth of odor-causing bacteria.

In foot creams and balms, Piroctone olamine cosmetic grade can contribute to maintaining foot hygiene by preventing the proliferation of microorganisms associated with unpleasant odors and skin conditions.
Piroctone olamine cosmetic grade is used in certain intimate care products, such as washes and wipes, providing antimicrobial benefits in delicate areas while being gentle on the skin.
Some sunscreen formulations may include Piroctone olamine cosmetic grade for its antimicrobial effects, especially in products designed for use in humid or warm conditions.

Piroctone olamine cosmetic grade may be found in acne spot treatments, where its antimicrobial properties are utilized to target and address specific blemishes.
In after-sun lotions or creams, Piroctone olamine cosmetic grade can contribute to skin comfort and hygiene after exposure to the sun.
Certain baby lotions, creams, or wipes may contain Piroctone olamine cosmetic grade to provide mild antimicrobial benefits while being suitable for sensitive baby skin.

Piroctone olamine cosmetic grade may be included in cosmetic primers to contribute to skin health and hygiene as part of the makeup application routine.
Due to its antimicrobial properties, Piroctone olamine cosmetic grade may be used in barrier creams designed to protect the skin from external factors while maintaining skin health.
In tinted moisturizers, Piroctone olamine cosmetic grade can provide not only moisturization but also contribute to maintaining a balanced and healthy complexion.

Piroctone olamine cosmetic grade might be included in certain foundation formulations, contributing to the overall health of the skin while providing coverage.
Piroctone olamine cosmetic grade's antimicrobial properties can be beneficial in cosmetic sticks, helping to maintain the hygiene of the product during application.
Piroctone olamine cosmetic grade may be used in various men's grooming products, including shaving creams or aftershave lotions, contributing to skin health and hygiene.

As an emollient and antimicrobial agent, Piroctone olamine cosmetic grade is incorporated into cosmetic emulsions, contributing to product stability and skin benefits.
Some anti-aging formulations may contain Piroctone olamine cosmetic grade for its skin-conditioning properties in addition to addressing microbial concerns.
Piroctone olamine cosmetic grade can be found in various color cosmetic products, such as eyeshadows or blushes, contributing to product hygiene and skin health.

Safety profile:
Piroctone olamine cosmetic grade is safe for use when added under the recommended percentage usage - 0.1% for rinse-off products and 0.5% for leave-on products.
Piroctone olamine cosmetic grade suits all skin and hair types, however, a patch test should be performed before full application.
Lastly, Piroctone olamine cosmetic grade is not used in organic products because it is a chemical preservative.

While Piroctone olamine cosmetic grade is generally well-tolerated, some individuals may be sensitive or allergic to it.
Patch testing is advisable, especially for individuals with a history of skin sensitivity.
Direct contact with the eyes should be avoided, as it may cause irritation.

In case of accidental contact, rinsing the eyes thoroughly with water is recommended.
Inhalation of cosmetic products containing Piroctone olamine cosmetic grade should be minimized.
Adequate ventilation is important, particularly in occupational settings where exposure levels may be higher.

Cosmetic products are not intended for ingestion.
Ingesting products containing Piroctone olamine cosmetic grade is not recommended, and consumers should seek medical attention if ingestion occurs accidentally.
PIVALOYL CHLORIDE
Pivaloyl chloride, also known as Trimethylacetic acid chloride, is a colorless and volatile liquid with a strong odor.
Pivaloyl chloride is a colorless to light yellow liquid with a pungent odor.
Pivaloyl chloride (PIVCL) is used in the production of pharmaceuticals and agrochemicals.

CAS Number: 3282-30-2
EC Number: 221-921-6
Chemical Formula: C5H9ClO
Molar Mass: 120.58 g·mol−1

Synonyms: Pivaloyl chloride, 3282-30-2, Trimethylacetyl chloride, 2,2-DIMETHYLPROPANOYL CHLORIDE, Propanoyl chloride, 2,2-dimethyl-, Pivalyl chloride, 2,2-Dimethylpropionyl chloride, Pivalic acid chloride, Pivalolyl chloride, pivalic chloride, Neopentanoyl chloride, 2,2-dimethyl-propionyl chloride, JQ82J0O21T, 2,2,2-trimethylacetyl chloride, DTXSID4027529, 2,2-dimethylpropionic acid chloride, pivaloylchloride, Pivaloyl chlorid, pivaloylchlorid, UNII-JQ82J0O21T, Pvaloyl chlorde, PivCl, pivaloyl-chloride, 2,2, Dimethyl-propanoyl chloride, tBuCOCl, Piv-Cl, t-BuCOCl, EINECS 221-921-6, UN2438, PVCL, trimethylacetylchloride, trimethylacetyl choride, trimehtylacetyl chloride, trimethyl acetylchloride, Trimethylacetyl-chloride, t-butylcarbonyl chloride, trimethylacetoyl chloride, Trimethyl acetyl chloride, (CH3)3CCOCl, tert-butylcarbonyl chloride, EC 221-921-6, Acetyl chloride, trimethyl-, SCHEMBL1404, trimethylacetic acid chloride, 2,2-dimethylpropanoylchloride, 2,2-dimethylpropionylchloride, 2,2,2-trimethylacetylchloride, 2,2-Dimethyl-propionylchloride, Trimethylacetyl chloride, 99%, DTXCID907529, TERT-BUTYL CHLORO KETONE, 2,2-dimethyl propanoyl chloride, CHEMBL3183814, 2,2-dimethylpropionicacid cloride, STR00119, ZINC1534960, Tox21_200646, BBL011382, MFCD00000709, STL146483, 2,2-Dimethyl-propionic acid chloride, AKOS000121190, UN 2438, NCGC00248779-01, NCGC00258200-01, 1,1-DIMETHYLETHANECARBONYL CHLORIDE, CAS-3282-30-2, FT-0652320, P0677, Pivaloyl chloride, purum, >=98.0% (GC), EN300-19178, Trimethylacetyl chloride [UN2438] [Poison], A821441, J-523982, Q2017164, F2190-0014, 2,2-Dimethylpropanoyl chloride [ACD/IUPAC Name], 2,2, Dimethylpropanoylchlorid [German] [ACD/IUPAC Name], 221-921-6 [EINECS], 3282-30-2 [RN], Chlorure de 2,2-diméthylpropanoyle [French] [ACD/IUPAC Name], Pivaloyl chloride, PIVALYL CHLORIDE, Propanoyl chloride, 2,2-dimethyl- [ACD/Index Name], Trimethylacetyl chloride, [503-30-0] [RN], 1,3-Propylene oxide, 102382 [Beilstein], 15722-48-2 [RN], 2,2,2-Trimethylacetyl chloride, 2,2-Dimethyl-propionyl chloride, 2,2-Dimethylpropionyl Chloride, 2,2-Dimethylpropionyl chloride, Trimethylacetyl chloride, Acetyl chloride, trimethyl-, Cyclooxabutane, MFCD00005167 [MDL number], Neopentanoyl chloride, Oxetane [ACD/Index Name] [ACD/IUPAC Name] [Wiki], PI-44939, Pivalic acid chloride, Pivalolyl chloride, PivaloylChloride, RQ6825000, STR00119, tert-Valeryl chloride, Trimethylacetyl chloride [UN2438] [Poison], Trimethylacetylchloride, Trimethylene Oxide, UN 2438

Pivaloyl chloride is a branched-chain acyl chloride.
Pivaloyl chloride was first made by Aleksandr Butlerov in 1874 by reacting pivalic acid with phosphorus pentachloride.

Pivaloyl chloride is used as an input in the manufacture of some drugs, insecticides and herbicides.

Pivaloyl chloride (PC) is a reactive compound that is used in the synthesis of pharmaceuticals, dyes, and other organic compounds.
Pivaloyl chloride can be used as a precursor to amides, which are important pharmacological agents.

PC undergoes chemiluminescence when reacted with hydrogen fluoride and potassium dichromate in the presence of an amide.
This reaction mechanism can be used to detect small amounts of PC in solution.
PC has been shown to have anti-inflammatory effects in autoimmune diseases and has been investigated for use as a cox-2 inhibitor.

Pivaloyl chloride, also known as Trimethylacetic acid chloride, is a colorless and volatile liquid with a strong odor.
Pivaloyl chloride is an alkylating reagent and is widely used in organic synthesis for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.
Pivaloyl chloride is also used in the manufacture of drugs, pesticides, and other compounds.

Pivaloyl chloride is a colorless to light yellow liquid with a pungent odor.
Pivaloyl chloride hydrolyses in the presence of water.

Pivaloyl chloride (PIVCL) is used in the production of pharmaceuticals and agrochemicals.

Pivaloyl chloride is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.
Pivaloyl chloride is used in formulation or re-packing, at industrial sites and in manufacturing.

Pivaloyl chloride is a natural product found in Rhodiola rosea with data available.
Pivaloyl chloride appears as colorless fuming liquid with a pungent odor.

Pivaloyl chloride is very toxic by inhalation, ingestion or skin absorption.
Pivaloyl chloride is fumes irritate the eyes and mucous membranes.
Pivaloyl chloride is corrosive to most metals and tissue.

Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria.
Pivaloyl chloride is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament.
In addition to this, Pivaloyl chloride is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine.

Pivaloyl chloride is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Pivaloyl chloride market an overview:
Pivaloyl chloride is classified as a harmful chemical with many restrictions on Pivaloyl chloride handling and storage.
Pivaloyl chloride is used as a building block in the pharmaceutical and agrochemical industry.

In pharmaceutical industries, Pivaloyl chloride serves as an important acylating reagent.
Pivaloyl chloride is a major raw material used in the synthesis of amides and lipids.

Different important drugs that are manufactured using Pivaloyl chloride are Benzylpenicillin, adrenaline, cefazolin, and other drugs.
In agrochemical industries, Pivaloyl chloride finds Pivaloyl chloride application in pesticide intermediates production.
The major product agrochemical obtained from Pivaloyl chloride is Chloropivaloyl chloride.

In chemical industries, Pivaloyl chlorides are used in the synthesis of ketones, amino groups, and anhydrides.

Pivaloyl chloride market dynamics:
The global consumption of Pivaloyl chlorides is mainly associated with the growth in pharmaceutical and agrochemical industries.
Which are the major drivers for the growth of the Pivaloyl chlorides market around the world.

The global Pivaloyl chloride market is consolidated to a few global and regional players only.
Major players in global Pivaloyl chloride markets are mainly from China and India.

These countries are global leaders of agrochemical substances.
The demand for agrochemicals in these regions is mainly accelerated due to the government's positive attitude towards agriculture.

The government of India has launched initiatives like Pradhan Mantri Krishi Sinchai Yojana(PMKSY), which helps to support farmers in these regions.
With these schemes, the government is targeting an increase in the country's revenue from agriculture sectors.

This positive attitude in the development of the agriculture sector will boost the global Pivaloyl chloride Market in these countries.
The same strategy is followed by various other developing countries of Asia and other parts of the world.

The fluctuating international currency has negative impacts on the Pivaloyl chloride market.
Pivaloyl chloride high flammability and corrosiveness have also raised the safety concerns for the manufacturer's Transportation of Pivaloyl chloride to involve high risk.
These are some of the restraining factors for the growth of the Pivaloyl chloride market.

Pivaloyl chloride market analysis:
Agrochemical industries have grown significantly in the Asia Pacific region due to the rising demand for food crops in these regions.
China and India are leading producers of the agrochemical, which is utilized in regional development in the agriculture sector.
Thus overall consumption Pivaloyl chlorides expected to witness significant growth in these regions.

The global Pivaloyl chloride market in China and India is experiencing higher growth due to several government inanities, which are encouraging the growth of agriculture in these regions.
Besides agrochemical industries, pharmaceuticals and chemical industries have shown significant growth in Asia Pacific regions, which leverages the global Pivaloyl chloride market.

The pharmaceutical industries have been growing at higher single digits CAGR in Europe and America.
Since the application of Pivaloyl chlorides is associated with drug manufacturing, the global Pivaloyl chlorides are expected to rise in these regions.
The agriculture sector being the least contributing sector to the country`s GDP of the United States, contributes a very less to global Pivaloyl chlorides market.

The Latin American & Middle East & Africa markets for Pivaloyl chloride will show stagnant growth in the forecast period due to limited growth in agrochemical and pharmaceutical industries in these regions.

Pivaloyl Chloride Market Snapshot (2022 to 2032):
The global pivaloyl chloride demand is anticipated to rise at a CAGR of 4.3% to 6% during the forecast period between 2022 and 2032.
Rising applications of pivaloyl chloride across pharmaceutical and agrochemical industries are driving growth in the global pivaloyl chloride market.

Pivaloyl Chloride, also called 2, 2- dimethyl propanol chloride, is a branded chain acyl chloride with a pungent odor.
Pivaloyl chloride is being increasingly used as a building block in agrochemical, pharmaceutical, and refining chemicals industries.

Over the years, pivaloyl chloride has become a commonly used intermediate for the production of agricultural chemicals like insecticides, herbicides, pesticides, pharmaceutical compounds, and in peroxy esters manufacturing.
The rapid expansion of the pharmaceutical industry triggered by the increasing prevalence of various chronic and infectious diseases, growing health awareness, and increasing spending on medicines is expected to push the demand for pivaloyl chloride during the forecast period.
Pivaloyl chloride is being extensively used to manufacture pharmaceutical products such as DPE, cefazolin, dipivefrin, aminobenzylpenicilin, cephalexin, and digitally epinephrine.

Driving Demand in Pivaloyl Chloride Market:
The rapid growth of end-use industries such as chemical, agrochemical, and pharmaceutical is a major factor driving the demand for pivaloyl chloride.

Pivaloyl chloride has become an ideal intermediate candidate for manufacturing a wide range of pharmaceutical and agrochemical products.

Factors such as a surge in diseases worldwide and increasing healthcare spending have ignited the growth of the pharmaceutical industry worldwide.
People are spending large amounts on pharmaceutical drugs.
As many of these pharmaceuticals are manufactured by using pivaloyl chloride as an intermediate, the rising dale for these products will eventually push the demand for pivaloyl chloride during the forecast period.

Similarly, rising concerns about food insecurity are prompting farmers to use agrochemicals like herbicides, fertilizers, pesticides, etc.
According to the Food and Agriculture Organization (FAO) of the United Nations, globally, hunger levels remained alarmingly high during 2021 with around 193 million people facing acute food insecurity.
This is acting as a catalyst for the growth of the pivaloyl chloride market and the trend is likely to continue during the forecast period.

Challenges Faced by the Pivaloyl Chloride Industry:
Despite multiple applications of pivaloyl chloride, there are certain factors that are limiting the growth of the pivaloyl chloride industry.
Some of these factors include the presence of stringent regulations pertaining to the use of insecticides and pesticides, the hazardous nature of pivaloyl chloride, and the availability of various alternative pharmaceutical and pesticide intermediates.

Various countries are introducing regulations on the excessive use of insecticides and pesticides as they are harmful to humans, animals, and the environment.
This in turn is creating major challenges for manufacturers of pivaloyl chloride.

Scientific Research Applications of Pivaloyl chloride:
Pivaloyl chloride is used in a variety of scientific research applications, such as the synthesis of peptides, the synthesis of heterocyclic compounds, and the synthesis of amines.
Pivaloyl chloride is also used in the synthesis of polymers, such as polystyrene and polyethylene.
In addition, Pivaloyl chloride is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Uses of Pivaloyl chloride:
Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria.
Pivaloyl chloride is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament.

In addition to this, Pivaloyl chloride is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine.
Pivaloyl chloride is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Pivaloyl chloride is used as a chemical intermediate.
Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria.

Pivaloyl chloride is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament.
In addition to this, Pivaloyl chloride is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine.

Pivaloyl chloride is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Uses at industrial sites:
Pivaloyl chloride has an industrial use resulting in manufacture of another substance (use of intermediates).
Pivaloyl chloride is used for the manufacture of: chemicals.
Release to the environment of Pivaloyl chloride can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).

Industry Uses:
Intermediate
Intermediates

General Manufacturing Information of Pivaloyl chloride:

Industry Processing Sectors:
All Other Basic Organic Chemical Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Pharmaceutical and Medicine Manufacturing

Synthesis Method of Pivaloyl chloride:
Pivaloyl chloride is synthesized from trimethylacetic acid and thionyl chloride.
The reaction is carried out in a sealed tube or flask at a temperature of 40-60°C.

The reaction is exothermic and the reaction is complete in about 2 hours.
The yield of the reaction is usually in the range of 75-95%.

Chemical Structure of Pivaloyl chloride:
A chemical structure of a molecule includes the arrangement of atoms and the chemical bonds that hold the atoms together.
The Pivaloyl chloride molecule contains a total of 15 bond(s).
There are 6 non-H bond(s), 1 multiple bond(s), 1 rotatable bond(s), 1 double bond(s) and 1 acyl halogenide(s) (aliphatic).

The 2D chemical structure image of Pivaloyl chloride is also called skeletal formula, which is the standard notation for organic molecules.
The carbon atoms in the chemical structure of Pivaloyl chloride are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated with enough hydrogen atoms to provide the carbon atom with four bonds.

The 3D chemical structure image of Pivaloyl chloride is based on the ball-and-stick model which displays both the three-dimensional position of the atoms and the bonds between them.
The radius of the spheres is therefore smaller than the rod lengths in order to provide a clearer view of the atoms and bonds throughout the chemical structure model of Pivaloyl chloride.

Reactivity Profile of Pivaloyl chloride:
Pivaloyl chloride is acidic.
Incompatible with bases (including amines), strong oxidizing agents, and alcohols.
May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts.

Handling and Storage of Pivaloyl chloride:

Nonfire Spill Response:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
All equipment used when handling Pivaloyl chloride must be grounded.

Do not touch or walk through spilled material.
Stop leak if you can do it without risk.

Prevent entry into waterways, sewers, basements or confined areas.
A vapor-suppressing foam may be used to reduce vapors.

SMALL SPILL:
Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal.
Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL:
Dike far ahead of liquid spill for later disposal.
Water spray may reduce vapor, but may not prevent ignition in closed spaces.

First Aid Measures of Pivaloyl chloride:
Call 911 or emergency medical service.
Ensure that medical personnel are aware of Pivaloyl chloride(s) involved and take precautions to protect themselves.

Move victim to fresh air if it can be done safely.
Give artificial respiration if victim is not breathing.

Do not perform mouth-to-mouth resuscitation if victim ingested or inhaled Pivaloyl chloride; wash face and mouth before giving artificial respiration.
Use a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.

In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
Wash skin with soap and water.

In case of burns, immediately cool affected skin for as long as possible with cold water.
Do not remove clothing if adhering to skin.

Keep victim calm and warm.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.

Fire Fighting of Pivaloyl chloride:
The majority of these products have a very low flash point.
Use of water spray when fighting fire may be inefficient.

Methanol (UN1230) will burn with an invisible flame.
Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE:
Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE:
Water spray, fog or alcohol-resistant foam.
If it can be done safely, move undamaged containers away from the area around the fire.

Dike runoff from fire control for later disposal.
Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS:
Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.

Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

For massive fire, use unmanned master stream devices or monitor nozzles.
If this is impossible, withdraw from area and let fire burn.

Accidental Release Measures of Pivaloyl chloride:

Isolation and Evacuation:

IMMEDIATE PRECAUTIONARY MEASURE:
Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

FIRE:
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Identifiers of Pivaloyl chloride:
CAS Number: 3282-30-2
Beilstein Reference: 102382
ChEMBL: ChEMBL3183814
ChemSpider: 56272
ECHA InfoCard: 100.019.929
EC Number: 221-921-6
PubChem CID: 62493
UNII: JQ82J0O21T
UN number: 2438
CompTox Dashboard (EPA): DTXSID4027529
InChI: InChI=1S/C5H9ClO/c1-5(2,3)4(6)7/h1-3H3
Key: JVSFQJZRHXAUGT-UHFFFAOYSA-N
SMILES: CC(C)(C)C(=O)Cl

Synonym(s): Pivaloyl chloride, Trimethylacetyl chloride
Linear Formula: (CH3)3CCOCl
CAS Number: 3282-30-2
Molecular Weight: 120.58
Beilstein: 385668
EC Number: 221-921-6
MDL number: MFCD00000709
PubChem Substance ID: 24900440
NACRES: NA.22

CAS number: 3282-30-2
EC number: 221-921-6
Hill Formula: C₅H₉ClO
Chemical formula: (CH₃)₃CCOCl
Molar Mass: 120.58 g/mol
HS Code: 2915 90 70

EC / List no.: 221-921-6
CAS no.: 3282-30-2
Mol. formula: C5H9ClO

Product Number: P0677
Purity / Analysis Method: >98.0%(T)
Molecular Formula / Molecular Weight: C5H9ClO = 120.58
Physical State (20 deg.C): Liquid
Storage Temperature: 0-10°C
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Moisture Sensitive,Heat Sensitive
CAS RN: 3282-30-2
Reaxys Registry Number: 385668
PubChem Substance ID: 125310048
SDBS (AIST Spectral DB): 2154
MDL Number: MFCD00000709

Properties of Pivaloyl chloride:
Chemical formula: C5H9ClO
Molar mass: 120.58 g·mol−1
Density: 0.985
Melting point: −57 °C (−71 °F; 216 K)
Boiling point: 105.5 °C (221.9 °F; 378.6 K)
Refractive index (nD): 1.412

Boiling point: 105 °C (1013 hPa)
Density: 0.98 g/cm3 (20 °C)
Explosion limit: 1.9 - 7.4 %(V)
Flash point: 13 °C
Ignition temperature: 455 °C
Melting Point: 87 - 88 °C
Vapor pressure: 38.59 hPa (20 °C)

Vapor density: >1 (vs air)
Quality Level: 200
Vapor pressure: 36 mmHg ( 20 °C)
Assay: 99%
Refractive index: n20/D 1.412 (lit.)
bp: 105-106 °C (lit.)
Density: 0.979 g/mL at 25 °C (lit.)
SMILES string: CC(C)(C)C(Cl)=O
InChI: 1S/C5H9ClO/c1-5(2,3)4(6)7/h1-3H3
InChI key: JVSFQJZRHXAUGT-UHFFFAOYSA-N

Molecular Weight: 120.58
XLogP3-AA: 2.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 1
Exact Mass: 120.0341926
Monoisotopic Mass: 120.0341926
Topological Polar Surface Area: 17.1 Ų
Heavy Atom Count: 7
Complexity: 80.6
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Pivaloyl chloride:
Assay (morpholine method): ≥ 98.0 %
Density (d 20 °C/ 4 °C): 0.979 - 0.982
Identity (IR): passes test

Related Products of Pivaloyl chloride:
1,1-Dimethoxybutane
(E)-6,6-Dimethyl-2-hept-1-en-4-yn-1-amine
2,2-dimethoxybutane
Dimethyl trans-3-Hexenedioate
Dimethyl Hydroxyaspartate, Mixture of Diastereomers

Names of Pivaloyl chloride:

Regulatory process names:
Pivaloyl chloride
Pivaloyl chloride
pivaloyl chloride
TRIMETHYLACETYL CHLORIDE
Directive, Annex II - RID

CAS names:
Propanoyl chloride
2,2-dimethyl-

IUPAC names:
2,2-Dimethylpropanoyl chloride
2,2-dimethylpropanoyl chloride
2,2-dimethylpropanoylchloride
2,2-dimethylpropionic acid chloride
Pivaloyl Chloride

Preferred IUPAC name:
2,2-Dimethylpropanoyl chloride

Trade names:
1,1-Dimethylethanecarbonyl chloride
2,2-Dimethylpropanoyl chloride
2,2-Dimethylpropionic acid chloride
2,2-Dimethylpropionyl chloride
Neopentanoyl chloride
Pivalic acid chloride
Pivalolyl chloride
pivaloyl chloride
Pivaloyl chloride (6CI, 7CI, 8CI)
Pivaloylchlorid
Pivalyl chloride
Propanoyl chloride, 2,2-dimethyl-
Propanoyl chloride, 2,2-dimethyl- (9CI)
tert-Butyl chloro ketone
tert-Butylcarbonyl chloride
Trimethylacetyl chloride

Other names:
Trimethylacetyl chloride
Pivaloyl chloride
Pivalyl chloride
neopentanoylchloride

Other identifier:
3282-30-2
Pinacolborane
4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE; PINACOLBORANE; Pinacolboronane; 4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE, 1M SOLUTION IN TETRAHYDROFURAN; 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-; 4,4,5,5-tetramethyl-1,3,2-dioxaborolane solution; Pinacolborane (PINB); 4,4,5,5-TETRAMETHYL-1,3,2-DIOXA-&; 4,4,5,5-Tetramethyl-1,3-dioxa-2$l^{2}-boracyclopentane; 4,4,5,5-Tetramethyl-1,3,2-dioxaborole; 4,4,5,5-Tetramethyl-1,3-dioxa-2-boracyclopentane CAS NO:25015-63-8
Pinane Hydroperoxide
cas no 85-44-9 1,3-Isobenzofuranidone; 1,3-Dioxophthalan; Phthalandione; 1,3 Phthalandione; 1,2-Benzenedicarboxylic acid anhydride; Phthalic acid anhydride; 1,2-Benzenedicarboxylic anhydride; 1,3-dihydro-1,3-dioxoisobenzofuran;
Pioglitazone
SYNONYMS:Pioglitazone hydrochloride;5-[4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl] thiazolidine-2,4-dione, Hydrochloride; Actos; 5-(p-(2-(5-Ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione monohydrochloride; Other CAS RN: 105355-27-9; 198077-89-3; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride, Pioglitazone hydrochloride cas no:111025-46-8 (Base) 112529-15-4 (HCl)
piper aurantiacum
extract of the fruit of piper aurantiacum, piperaceae; piper wallichii fruit extract CAS NO:84929-41-9
Piperazines
SYNONYMS Diethylenediamine; Diethyleneimine; Dispermine;Antiren; Hexahydropyrazine; Piperazidine; Pipersol; Pyrazine hexahydride; Uvilon; 1,4-Diazacyclohexane; 1,4-Piperazine; 1,4-Diethylenediamine; Piperazin (German); N,N-Diethylenediamine; Hexahydro-1,4-diazine; Piperazidine; Pyrazine hexahydrate; Piperazin CAS NO: 110-85-0
Pirinç Ekstraktı
Oryza Sativa Extract; extract of the grains of the rice, oryza sativa l., poaceae;lipoplastidine oryza furfur (Vevy); extrapone rice (Symrise); rice extract cas no:90106-37-9
Pirinç Kepeği Vaks
RICE BRAN WAX ; rice bran wax; waxes and waxy substances from rice bran; rice wax; oryza sativa bran wax; florabeads; naturebead CAS NO:8016-60-2
PİZZA AROMASI
pizza flavor
Plankton Extract
PLANKTON EXTRACT;Plankton, marine, ext.;Marine plankton extract CAS: 91079-57-1
Plantago lanceolata
plantago lanceolata leaf extract; extract of the leaves of the english plantain, plantago lanceolata l., plantaginaceae; plantago sinuata leaf extract; english plantain leaf extract; plantain plantago lanceolata extract; ribwort leaf extract; ribwort plantain leaf extract CAS NO:85085-64-9
PLANTAIN EXTRACT
Before you start thinking about the fruit that is part of the banana family, it’s important to note that Plantain Extract comes from a different species of this family.
The Plantain Extract used in skin care most often comes from the leaves of Plantago major, which is a low-growing perennial weed found throughout most of North America.


Cas Number: 85085-64-9
Einecs Number: 285-388-1
Chem/IUPAC Name: Plantago Lanceolata Leaf Extract is an extract of the leaves of the English Plantain, Plantago lanceolata L., Plantaginaceae


Plantago Extract is an extract of the leaves of the plantain, Plantago lanceolata, Plantaginaceae.
Plantain is native to temperate Eurasia and has since spread across the Americas and Australia.
Plantain Extract loves disturbance and is a common weed of cultivated pastures, cracks in sidewalks, backyard gardens, and any place that experiences regular activity.


Plantain Extract was highly regarded by the Saxons and was considered one of their nine sacred herbs.
This plant, Plantain Extract, has been used by many cultures the world over.
Plantain has a long history of being utilized for a variety of healthful benefits and as an edible food.


Plantain Extract can be valuable externally and is often found in skin care products, especially for its drawing abilities.
This cooling and moistening herb is commonly steeped as tea and combined with other botanicals in herbal infusions.
Plantain Extract is made in small batches at our extract facilities in Eugene, Oregon by our expert team for quality and efficacy.


Delicately aromatic plantain extract can be taken in water or juice, or combined with other extracts including meadowsweet extract, chamomile extract, or catnip extract.
Try a little plantain tincture in some freshly infused happy tummy tea for an additional enhancement.


Plantain Extract contains allantoin as does comfrey.
Plantain Extract is water Soluble.
Plantain Extract is preserved with sodium benzoate and ethanol.


Plantain Extract is a flowering herb that soothes inflamed and irritated skin caused by insect bites, acne, rosacea, and other skin disorders.
Before you start thinking about the fruit that is part of the banana family, it’s important to note that Plantain Extract comes from a different species of this family.


The Plantain Extract used in skin care most often comes from the leaves of Plantago major, which is a low-growing perennial weed found throughout most of North America.
Plantain Extract may also ease itchiness and flaking caused by dandruff.



USES and APPLICATIONS of PLANTAIN EXTRACT:
Plantain Extract is a hydroglycolic extract obtained from the leaves of plantain (Plantago lanceolata).
Plantain Extract is obtained through a controlled extraction process using propylene glycol and water.
Plantain Extract appears as a slightly translucent to opaque liquid, with a possible slight precipitate, and has a characteristic odor.


Plantain Extract is miscible in water and 50% v/v alcohol and is widely used in cosmetic products.
Plantain Extract is used in all types of anti-aging formulations: prevention and regeneration, daytime care products, especially for mature skin, anti-wrinkle treatments, sun care healing, and anti-inflammatory formulations.


Plantain Extract improves collagen production, is antioxidant, anti-inflammatory, and has antimicrobial properties.
Among its active ingredients, Plantain Extract contains 6% mucilage (arabinogalactan, rhamnogalacturonan, glucomannan), pectin, tannins, phenol carboxylic acids (chlorogenic, neochlorogenic, gentisic, protocatechuic), flavonoids (apigenol, luteoloside), mineral salts (silicon, zinc, potassium ), coumarins (esculetin), and iridoid glycosides (asperuloside, aucubin, and catalpol).


Topically, Plantain Extract's use is recommended for conjunctivitis, blepharitis, rhinitis, gingivitis, glossitis, dry eczema, herpes, ichthyosis, psoriasis, and burns.
Plantain Extract is ideal for dry skin or eczema problems.


Plantain Extract is effective against insect bites.
Plantain Extract has long been considered by herbalists to be a useful remedy for cough, wounds, inflamed skin or dermatitis, and insect bites.
Plantain Extract is bruised or crushed leaves have been applied topically to treat insect bites and stings, eczema, and small wounds or cuts.


Plantain Extract is cosmetic grade & for external use only.
Cosmetic Uses of Plantain Extract: antimicrobial agents
Plantain Extractis rich in antioxidants and protects the scalp and hair from environmental stressors and free radical damage.


Plantain Extract stimulates the scalp and hair follicles, thereby promoting better hair growth.
Plantain Extract has a long history of use for inflammation and pain. Plantain Extract is used for soothing and toning the skin.
Plantain Extract's active compound is allantoin, a natural compound with antibacterial and germicidal properties that make it useful as a topical skin healing treatment and an excellent ingredient for face masks.


Some of the benefits of allantoin have long been associated with cell regeneration and skin healing.
Allantoin works in a way similar to an exfoliator.
It removes dead skin cells from the outer layer of the epidermis, softening the skin's keratin and encouraging the growth of new skin cells.


Allantoin is an effective anti-irritant for the skin, calming and soothing sensitive areas.
Plantain Extract has been used to help promote the wound-healing effect, and because it helps with cell regeneration, it has been used to treat skin that has suffered abrasions or burns.


Plantain Extract has also been shown to calm eczema and other skin ailments.
Plantain Extract has the added benefit of promoting additional moisture in the area between cells, which helps keep your skin from moisture evaporating from the skin's surface.


-Dermatological Tips:
For acne sufferers, we recommend use of products containing Plantain Extract both morning and night.
If acne isn’t a concern, use Plantain Extract in the morning to take advantage of its benefits throughout the day.


-MEDICINE uses of Plantain Extract:
Plantain Extract has healing properties of body wounds.
Blood pressure lowering effect.
Plantain Extract is known that it is good for rashes and swelling caused by insect stings.
Plantain Extract is a plant that supports the weakening thanks to its toxin and edema-enhancing properties.


-HAIR CARE uses of Plantain Extract:
*Nourishes hair
*Adds vitality to hair


-SKIN CARE uses of Plantain Extract:
*Passes acne.
*Purifies skin from black spots


-FOOD uses of Plantain Extract:
*Aromatic, adds flavor to food.
*Plantain Extract is used as a flavoring agent in food and beverages.
*Plantain Extract is used as thickener in foods.


-VETERINARY MEDICINE uses of Plantain Extract:
*Plantain Extract is ethical against digestive problems.
Plantain Extract relaxes the stomach and is good for stomach diseases,
Plantain Extract is used in feed and medicine.



FUNCTIONS OF PLANTAIN EXTRACT:
*Skin conditioning : Maintains skin in good condition



WHAT DOES PLANTAIN EXTRACT DO IN A FORMULATION?
*Antimicrobial



IS PLANTAIN EXTRACT GOOD OR BAD FOR YOUR SKIN?
Sourced from the leaves of Plantago major, Plantain Extract offers numerous benefits when it comes to skin care products.
Not only is Plantain Extract a skin-soothing agent, it also has has germicidal and antibacterial properties.



TRY MEN’S SKIN CARE, PLANTAIN EXTRACT::
Benefits of Plantain Extract:
One of the big benefits of Plantain Extract is that it contains Allantoin, which is a powerful skin soothing agent that encourages cell growth.
In face washes, Allantoin is also used as a chemical exfoliant to remove layers of dead skin.
Plantain Extract has wound healing properties, which makes it great as an acne treatment.
Plantain Extract helps to combat acne and it promotes skin regeneration, which reduces the chance of scarring.
Plantain Extract has germicidal and antibacterial properties, which makes it that much more useful in the prevention of acne.
Since Plantain Extract soothes skin, it’s a good treatment for sunburn.



PHYSICAL and CHEMICAL PROPERTIES of PLANTAIN EXTRACT:
Physical State: liquid
Colour: brown



SYNONYMS:
Plantain Extract
Spitzwegerich
Spitzwegerich-Extrakt
Plantago Lanceolata Leaf Extract
Plantago Lanceolata Extract
Plantago lanceolata
P. major
P. psyllium
P. arenaria (P. ramosa) (Spanish or French psyllium seed)
P. ovata (Blond or Indian plantago seed).
Spanish psyllium
French psyllium
blond plantago
Indian plantago
psyllium seed
flea seed
black psyllium


PLASDONE S-630
DESCRIPTION:
Plasdone S-630 is a pharmaceutical oral care polymer which has excellent bioadhesion properties and is a tougher, more flexible film former than PVP.
Plasdone S-630 Copovidones a highly compressible powder, making it an excellent tablet binder for direct compression and dry granulation.
Plasdone S-630 is often used with poorly compressible actives to improve tablet breaking force and lower friability.
More recently, these polymers have been used in solid dispersions to increase solubility and thereby increase bioavailability of poorly soluble APIs.



Plasdone S-630 is a 60:40 linear, random copolymer of N-vinyl-2-pyrolidone (PVP) and vinyl acetate.
Plasdone S-630 acts as a tablet binder in denture cleanser tablets.



FEATURES & BENEFITS OF PLASDONE S-630:
Plasdone S-630 Acts as a tablet binder resulting in denture cleanser tablets with high breaking force and low friability
Plasdone S-630 Forms tough, clear, flexible films with high substantivity to skin
Plasdone S-630 is Vegan suitable



Plasdone S-630 copovidone is 60:40 copolymer of n-vinyl-2-pyrrolidone and vinylacetate.
The vinyl acetate in the polymer backbone lowers the polymer’s glass transition temperature compared with polyvinylpyrollidone (PVP) homopolymers and reduces hygroscopicity.
Plasdone S-630 acts as an excellent tablet binder in dry granulation and direct compression tablet process.

Plasdone S-630 is highly compressible and produces more flexible, less brittle films compared to films of PVP homopolymers.
Its lower hygroscopicity improves stability in high humidity.
Plasdone S-630 improves solubility and bioavailability of poorly soluble drug actives through formation of solid dispersions.
Plasdone S-630 copovidone forms tough, clear, flexible films with high substantivity.


Plasdone S-630 acts as a tablet binder resulting in tablets with high breaking force and low friability
Plasdone S-630 is a binder in dry-granulations and direct compression processes.
Plasdone S-630 is used in denture cleanser tablets

Plasdone S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate.
The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monomer reduces glass transition temperature (Tg) and hygroscopicity compared to homopolymers of pyrrolidone (PVP).

Well-known in the industry as a multipurpose excipient, copovidone functions as a binder, solubilizer/solid dispersion carrier and film former in a variety of pharmaceutical formulations
Plasdone S-630 Ultra copovidone is a grade of plasdone s-630 designed to provide better performance in tablet formulations, hot melt extrusion (HME) and continuous processing by offering superior benefits compared to the original plasdone s-630 copovidone.


SAFETY INFORMATION ABOUT PLASDONE S-630:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



PLATYCODON ROOT EXTRACT

Platycodon Root Extract, derived from the root of the Platycodon grandiflorus plant, is renowned for its anti-inflammatory, antioxidant, and expectorant properties.
Platycodon Root Extract is widely recognized in traditional Chinese medicine for its ability to support respiratory health, reduce inflammation, and promote detoxification.
This versatile extract offers both therapeutic and wellness benefits, helping to soothe the throat, improve lung function, and boost immune health.

CAS Number: 84696-21-9
EC Number: 283-323-5

Synonyms: Platycodon Root Extract, Balloon Flower Root Extract, Platycodon grandiflorus Extract, Chinese Bellflower Root Extract, Jie Geng Extract, Platycodon Herbal Extract, Platycodon Phytocomplex, Balloon Flower Bioactive Extract, Balloon Flower Root Active, Platycodon Radix Extract



APPLICATIONS


Platycodon Root Extract is extensively used in traditional respiratory remedies, providing natural support for lung health and helping to clear mucus from the respiratory tract.
Platycodon Root Extract is favored in the formulation of throat-soothing lozenges and syrups, where it helps to reduce cough, soothe throat irritation, and provide anti-inflammatory benefits.
Platycodon Root Extract is utilized in the development of natural expectorants, offering support for individuals with respiratory congestion and promoting the clearance of phlegm.

Platycodon Root Extract is widely used in traditional Chinese medicine formulations for its ability to relieve chronic bronchitis, asthma, and other respiratory conditions by promoting lung health.
Platycodon Root Extract is employed in the production of herbal teas and infusions, offering benefits for soothing a sore throat, reducing cough, and improving breathing.
Platycodon Root Extract is essential in the creation of wellness products designed to support respiratory function, reduce inflammation, and promote overall lung health.

Platycodon Root Extract is utilized in the production of immune-boosting supplements, helping to enhance immune response and protect the body from respiratory infections.
Platycodon Root Extract is a key ingredient in formulations that address seasonal respiratory issues, such as colds, flu, and allergies, providing natural relief for congestion and inflammation.
Platycodon Root Extract is used in the development of anti-inflammatory supplements, where it offers relief from respiratory inflammation and irritation.

Platycodon Root Extract is applied in the formulation of detox teas, helping to support lung health while promoting the elimination of toxins from the body.
Platycodon Root Extract is employed in the creation of herbal remedies for relieving chest congestion, helping to clear the lungs and promote easier breathing.
Platycodon Root Extract is used in traditional herbal formulations to support the respiratory system, addressing chronic coughs and promoting the clearance of mucus.

Platycodon Root Extract is widely utilized in formulations designed for smokers, providing support for lung detoxification and helping to improve respiratory function.
Platycodon Root Extract is a key component in the development of holistic wellness products aimed at supporting respiratory health and reducing the effects of air pollution on lung function.
Platycodon Root Extract is used in the production of herbal tinctures, providing natural support for respiratory issues, especially those related to chronic conditions such as asthma or bronchitis.

Platycodon Root Extract is employed in the formulation of natural remedies for treating respiratory infections, offering benefits for reducing inflammation, clearing mucus, and improving overall lung health.
Platycodon Root Extract is applied in the development of respiratory health capsules, offering immune-boosting and anti-inflammatory properties that support lung function and respiratory wellness.
Platycodon Root Extract is utilized in the creation of wellness beverages designed to soothe the respiratory system and reduce coughing and throat irritation.

Platycodon Root Extract is found in formulations designed to relieve sinus congestion, providing natural support for opening up airways and improving breathing.
Platycodon Root Extract is used in the production of holistic detox products, helping to cleanse the respiratory system and eliminate harmful pollutants and toxins.
Platycodon Root Extract is a key ingredient in wellness teas, where it offers respiratory and immune support while promoting relaxation and relief from congestion.

Platycodon Root Extract is widely utilized in the development of supplements that address chronic respiratory conditions, helping to improve overall lung function and reduce inflammation.
Platycodon Root Extract is a reliable component in the creation of natural treatments for allergy-related respiratory issues, offering support for reducing symptoms such as sneezing, coughing, and nasal congestion.
Platycodon Root Extract is often found in formulations for lung-cleansing therapies, where it aids in the removal of phlegm and enhances breathing comfort.

Platycodon Root Extract is also integrated into formulations designed to treat sore throat and respiratory infections in children, offering safe and natural relief.
Platycodon Root Extract is used in herbal steam treatments for respiratory health, helping to open airways and improve breathing in individuals with sinus congestion.

Platycodon Root Extract is applied in topical formulations to help reduce chest congestion, providing a soothing and warming effect when combined with other natural ingredients.
Platycodon Root Extract is utilized in wellness drinks aimed at boosting lung capacity and promoting clearer breathing, especially for individuals living in polluted environments.

Platycodon Root Extract is commonly used in natural cough syrups for children and adults, providing effective relief from dry or phlegm-producing coughs.
Platycodon Root Extract is found in dietary supplements that support overall respiratory endurance, making it popular among athletes and individuals looking to improve lung health.

Platycodon Root Extract is a key ingredient in respiratory tonics used in traditional herbal therapies to enhance breathing and clear lung congestion.
Platycodon Root Extract is applied in natural remedies for reducing allergic reactions that impact the respiratory system, such as hay fever or allergic rhinitis.

Platycodon Root Extract is employed in air-purifying sprays and inhalants, offering respiratory support and relief from airborne allergens.
Platycodon Root Extract is utilized in combination with other herbs in wellness teas, where it enhances detoxification and supports overall lung function, especially for individuals recovering from respiratory illnesses.



DESCRIPTION


Platycodon Root Extract, derived from the root of the Platycodon grandiflorus plant, is renowned for its anti-inflammatory, antioxidant, and expectorant properties.
Platycodon Root Extract is widely recognized in traditional Chinese medicine for its ability to support respiratory health, reduce inflammation, and promote detoxification.

Platycodon Root Extract offers additional benefits such as soothing throat irritation, reducing coughing, and enhancing overall lung function.
Platycodon Root Extract is often incorporated into formulations designed to support the body's natural respiratory processes, promoting the clearance of phlegm and improving breathing.
Platycodon Root Extract is recognized for its ability to provide relief from chronic respiratory conditions such as bronchitis and asthma, supporting lung health and reducing inflammation.

Platycodon Root Extract is commonly used in both traditional and modern wellness formulations, providing a reliable solution for maintaining respiratory health and immune function.
Platycodon Root Extract is valued for its ability to soothe the throat, calm irritation, and support the body’s natural healing processes, making it a key ingredient in products that aim to promote lung health and reduce inflammation.
Platycodon Root Extract is a versatile ingredient that can be used in a variety of products, including lozenges, syrups, capsules, teas, and wellness beverages.

Platycodon Root Extract is an ideal choice for products targeting respiratory health, immune support, and detoxification, providing natural and effective care for these concerns.
Platycodon Root Extract is known for its compatibility with other lung-supporting and anti-inflammatory ingredients, allowing it to be easily integrated into multi-functional formulations.
Platycodon Root Extract is often chosen for formulations requiring a balance between respiratory relief, immune support, and detoxification, ensuring comprehensive wellness benefits.

Platycodon Root Extract enhances the overall effectiveness of wellness products by providing natural support for respiratory health, throat comfort, and lung detoxification.
Platycodon Root Extract is a reliable ingredient for creating products that offer noticeable improvements in lung function, congestion relief, and respiratory comfort.
Platycodon Root Extract is an essential component in innovative wellness products known for their performance, safety, and ability to support respiratory health and immune function.



PROPERTIES


Chemical Formula: N/A (Natural extract)
Common Name: Platycodon Root Extract (Platycodon grandiflorus Extract)
Molecular Structure:
Appearance: Brown to yellow powder or liquid extract
Density: Approx. 1.00-1.05 g/cm³ (for powder)
Melting Point: N/A (powder form)
Solubility: Soluble in water and ethanol; insoluble in oils
Flash Point: >100°C (for powder)
Reactivity: Stable under normal conditions; no known reactivity issues
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store between 15-25°C in a cool, dry place
Vapor Pressure: Low (for liquid extract)



FIRST AID


Inhalation:
If Platycodon Root Extract is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Wash the affected area with soap and water.
If skin irritation persists, seek medical attention.

Eye Contact:
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
If Platycodon Root Extract is ingested, do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE



Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE) such as gloves and safety goggles if handling large quantities.
Use in a well-ventilated area to avoid inhalation of dust.

Ventilation:
Ensure adequate ventilation when handling large amounts of Platycodon Root Extract to control airborne concentrations below occupational exposure limits.

Avoidance:
Avoid direct contact with eyes and prolonged skin contact.
Do not eat, drink, or smoke while handling Platycodon Root Extract.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Contain spills to prevent further release and minimize exposure.
Absorb with inert material (e.g., sand, vermiculite) and collect for disposal.
Dispose of in accordance with local regulations.

Storage:
Store Platycodon Root Extract in a cool, dry, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid inhalation of dust and direct contact with skin and eyes.
Use explosion-proof equipment in areas where dust or vapors may be present.


PLURIOL A 500 E
Pluriol A 500 E is a Pluriol A 500 E with an average molecular weight of 120.14698.
Pluriol A 500 E is a clear, odorless almost colorless, viscous liquid.
Pluriol A 500 E is heat stable and hygroscopic, and has a low vapor pressure.

CAS Number: 9004-74-4
Molecular Weight: 120.14698
EC Number: 215-801-2

Pluriol A 500 E is a polymer which is hydrolyzed by ethylene oxide.
Pluriol A 500 E has no toxicity and irritation.
Pluriol A 500 E is widely used in various pharmaceutical preparations.

The toxicity of low molecular weight Pluriol A 500 E is relatively large.
In general, the toxicity of diols is very low.
Topical application of Pluriol A 500 E, especially mucosal drug, can cause irritant pain.

In topical lotion, Pluriol A 500 E can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Pluriol A 500 E can occur in large doses of oral administration.
In injection, the maximum Pluriol A 500 E 300 concentration is about 30% (V/V).

Pluriol A 500 E could occur when the concentration is more than 40% (V/V).
Pluriol A 500 E grades are used as raw materials in the production of comb polymers applied as dispersants and plasticizers for concrete.
The low diol content of Pluriol A 500 E prevents undesirable side reactions.

Pluriol A 500 E is also used to change the chain length of polyurethanes.
Pluriol A 500 E is a medication that is used in the management and treatment of constipation.
Pluriol A 500 E is in the laxative class of drugs.

This activity describes the indications, action, and contraindications for Pluriol A 500 E as a valuable agent in the treatment of constipation.
Pluriol A 500 E, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments, and suppository base, and tablet and capsule lubricant.
Pluriol A 500 E has low toxicity with systemic absorption less than 0.5%.

Pluriol A 500 Es are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.

The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific Pluriol A 500 E product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific Pluriol A 500 Es.

Pluriol A 500 Es with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.

Pluriol A 500 E is also known as polyoxirane (PEO).
Pluriol A 500 E is a linear polyether obtained by ring opening polymerization of ethylene oxide.
Pluriol A 500 E contact lens liquid.

The viscosity of Pluriol A 500 E solution is sensitive to the shear rate and it is not easy for bacteria to grow on Pluriol A 500 E.
The condensation polymer of ethylene oxide and water.
Pluriol A 500 E is a cream matrix for preparing water-soluble drugs.

Pluriol A 500 E can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
Drug sustained-release and immobilized enzyme carrier.
The Pluriol A 500 E solution is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.

Pluriol A 500 E surface modification of medical polymer materials.
The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing Pluriol A 500 E on the surface of medical polymers.

Pluriol A 500 E, the process of attaching PEG molecules to drugs or drug carriers, can alter the pharmacokinetics of drugs, extending their circulation time in the body and potentially reducing immunogenicity.
Pluriol A 500 E can have various derivatives, such as those modified with different functional groups or chain lengths.
These derivatives can exhibit specific properties suited to particular applications.

Pluriol A 500 E can make the membrane of the alkanol contraceptive pill.
Pluriol A 500 E can make hydrophilic anticoagulant polyurethane.
Pluriol A 500 E 4000 is an osmotic laxative.

Pluriol A 500 E can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Pluriol A 500 E nontoxic and gelatinous nature can be used as a component of denture fixer.

Pluriol A 500 E are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation.
Pluriol A 500 E absorbs water from the solution, so it is also used to concentrate the solution.

Melting point: 64-66 °C
Boiling point: >250°C
Density: 1.27 g/mL at 25 °C
vapor density: >1 (vs air)
vapor pressure: refractive index: n20/D 1.469
Flash point: 270 °C
storage temp.: 2-8°C
solubility: H2O: 50 mg/mL, clear, colorless
form: waxy solid
color: White to very pale yellow
Specific Gravity: 1.128
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Merck: 14,7568
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃

Pluriol A 500 E is soluble in water, acetone, ethanol, ethyl acetate and toluene.
The two primary hydroxyl groups of Pluriol A 500 E undergo typical alcohol reactions to form monoesters, diesters, ethers, acetals and amines.
Pluriol A 500 E fatty esters are useful plasticizers for vinyl resins and other materials.

Polyesters of maleic acid are used commercially as copolymers with Vinyl monomers, styrene and vinyl esters.
The resins are used for impregnation and molding.
Pluriol A 500 Es are used as lubricants for the air bags in pneumatic tires.

Pluriol A 500 E is used to improve the solubility of poorly water-soluble drugs, enhancing their bioavailability and effectiveness.
Pluriol A 500 E's incorporated into drug delivery systems to modify the release profile of drugs, enabling controlled and sustained drug delivery.
Pluriol A 500 E provides moisturization and smoothness to the skin, making it a popular ingredient in lotions, creams, and moisturizers.

Pluriol A 500 E's used as an emulsifier in cosmetic formulations, helping blend water and oil-based ingredients.
Pluriol A 500 E is sometimes employed to functionalize nanoparticles and improve their biocompatibility and stability.
Pluriol A 500 E can also help nanoparticles evade the immune system, making them more suitable for medical applications like targeted drug delivery.

Suitable as paper softeners because of their humectant properties and low vapor pressure.
Pluriol A 500 E also used as plasticizers in the manufacture of uncoated cellophane and cellulose sponges.
Pluriol A 500 Es and their fatty acid derivatives are used for such varied purposes as emulsification, washing, lubrication, static prevention, pigment dispersion and softening in textiles and leather applications.

Pluriol A 500 E u sed in the production of steam set printing inks.
When used in combination with ethylene and diethylene glycols, they control the amount of moisture pickup in the setting of inks.

Uses
Pluriol A 500 E is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Pluriol A 500 E is soluble in water (mw 1,000) and many organic solvents.
Pluriol A 500 E (PEG) is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments.

Pluriol A 500 E are quite humectant up to a molecular weight of 500. Beyond this weight, their water uptake diminishes.
Pluriol A 500 E is used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of Pluriol A 500 E were used for drug delivery.

Pluriol A 500 E molecules of approximately 2000 monomers.
Pluriol A 500 E is used in various industrial applications due to its solubility and non-reactive nature:
Pluriol A 500 E can be used as a solvent or diluent in adhesive formulations.

Pluriol A 500 E can contribute to the properties of coatings, such as improved flow and leveling.
In laboratory settings, Pluriol A 500 E might be used as a component in various solutions or as a stabilizing agent.
Pluriol A 500 E nanoparticles are utilized for targeted drug delivery, enhancing drug accumulation in specific tissues while minimizing side effects.

Pluriol A 500 E is used in textile dyeing and finishing processes to enhance dye penetration and improve fabric properties.
Pluriol A 500 E and other PEG derivatives are used as stabilizers and excipients in a wide range of products:
Pluriol A 500 E derivatives are approved for use as food additives and stabilizers in certain food and beverage products.

Pluriol A 500 E derivatives can serve as emulsifiers, thickeners, and stabilizers in cosmetics, skincare products, and toiletries.
Pluriol A 500 E can be used in pesticide formulations to improve the dispersion of active ingredients and enhance their effectiveness.
Pluriol A 500 E can be added to paint formulations to improve the stability of pigments, enhance paint flow, and reduce defects.

Pluriol A 500 E can be present in household cleaners and disinfectants, aiding in solubilizing active ingredients and improving cleaning performance.
Pluriol A 500 E's used in some personal hygiene products like soaps and hand sanitizers for its emulsifying and cleansing properties.
Pluriol A 500 E can be used in industrial degreasing formulations due to its ability to solubilize oils and greases.

Pluriol A 500 E is used in textile dyeing and printing processes to improve dye dispersion and color uptake.
Pluriol A 500 E is used in various applications from industrial chemistry to biological chemistry.
Recent research has shown Pluriol A 500 E aintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.

Pluriol A 500 E is industrially produced as a lubricating substance for various surfaces to reduce friction.
Pluriol A 500 E is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.

Safety
Pluriol A 500 Es are widely used in a variety of pharmaceutical formulations.
Generally, they are regarded as nontoxic and nonirritant materials.
Adverse reactions to Pluriol A 500 Es have been reported, the greatest toxicity being with glycols of low molecular weight.

However, the toxicity of glycols is relatively low.
Pluriol A 500 Es administered topically may cause stinging, especially when applied to mucous membranes.
Hypersensitivity reactions to Pluriol A 500 Es applied topically have also been reported, including urticaria and delayed allergic reactions.

The most serious adverse effects associated with Pluriol A 500 Es are hyperosmolarity, metabolic acidosis, and renal failure following the topical use of Pluriol A 500 Es in burn patients.
Topical preparations containing Pluriol A 500 Es should therefore be used cautiously in patients with renal failure, extensive burns, or open wounds.
Oral administration of large quantities of Pluriol A 500 Es can have a laxative effect.

Therapeutically, up to 4 L of an aqueous mixture of electrolytes and high-molecular-weight Pluriol A 500 E is consumed by patients undergoing bowel cleansing.
Liquid Pluriol A 500 Es may be absorbed when taken orally, but the higher-molecular-weight Pluriol A 500 Es are not significantly absorbed from the gastrointestinal tract. Absorbed Pluriol A 500 E is excreted largely unchanged in the urine, although Pluriol A 500 Es of low molecular weight may be partially metabolized.

Synonyms
25322-68-3
POLYETHYLENEGLYCOL 6000
Pluriol A 500 E monomethylether
methoxyPluriol A 500 E.
PLURONIC FT L 61
PLURONIC FT L 61 PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. Because the lengths of the polymer blocks can be customized, many different PLURONIC FT L 61s exist that have slightly different properties. For the generic term PLURONIC FT L 61, these copolymers are commonly named with the letter P (for PLURONIC FT L 61) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = PLURONIC FT L 61 with a polyoxypropylene molecular mass of 4000 g/mo} PLURONIC FT L 61 and a 70% polyoxyethylene content). For the PLURONIC FT L 61 and Synperonic tradenames, coding of these copolymers starts with a letter to define PLURONIC FT L 61’s physical form at room temperature (L = liquid, P = paste, F = flake (solid)) followed by two or three digits, The first digit (two digits in a three-digit number) in the numerical designation, multiplied by 300, indicates the approximate molecular weight of the hydrophobe; and the last digit x 10 gives the percentage polyoxyethylene content (e.g., L61 indicates a polyoxypropylene molecular mass of 1800 g/mol and a 10% polyoxyethylene content). In the example given, PLURONIC FT L 61 181 (P181) = PLURONIC FT L 61 L61 and Synperonic PE/L 61. Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting. The PLURONIC FT L 61s have been shown to incorporate into cellular membranes affecting the microviscosity of the membranes. The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle. ). PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. PLURONIC FT L 61s are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide (PO) (OEx–POy–OEx). PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61s have been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells. PLURONIC FT L 61s have also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. The PLURONIC FT L 61s have also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles. An important characteristic of PLURONIC FT L 61 solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of PLURONIC FT L 61s are PLURONIC FT L 61s and poloxamines are also known as macromolecules, respectively. PLURONIC FT L 61s are a family of more than 50 different amphiphilic nonionic block polymers of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO), covering a range of liquids, pastes and solids. PLURONIC FT L 61s consist of a central polyoxypropylene (POP) molecule, which is flanked on both sides by two hydrophilic chains of polyoxyethylene (POE). A slightly different structure is exhibited by the poloxamines, which are tetrafunctional block copolymers with four POE–POP blocks joined together by a central ethylene diamine bridgeliquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in PLURONIC FT L 61s depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. Assessment of PLURONIC FT L 61s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, and PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, and PLURONIC FT L 61 182 Dibenzoate as Used in Cosmetics. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61s and poloxamines are also known as macromolecules, respectively. PLURONIC FT L 61s are a family of more than 50 different amphiphilic nonionic block polymers of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO), covering a range of liquids, pastes and solids. PLURONIC FT L 61s consist of a central polyoxypropylene (POP) molecule, which is flanked on both sides by two hydrophilic chains of polyoxyethylene (POE). A slightly different structure is exhibited by the poloxamines, which are tetrafunctional block copolymers with four POE–POP blocks joined together by a central ethylene diamine bridgeliquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in PLURONIC FT L 61s depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. Different phase diagrams characterizing all these transitions have been constructed for most PLURONIC FT L 61s using a great variety of experimental techniques (e.g. SAXS, PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. They also clean the skin and hair by helping water to mix with oil and dirt so that they can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance.Differential scanning calorimetry, viscosity measurements, light scattering). PLURONIC FT L 61s are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules whose self-assembling properties display a wide range of phase behavior. This ability to form micelles and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC). PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘PLURONIC FT L 61’ was coined by the inventor, Irving Schmolka, who received the patent for PLURONIC FT L 61s in 1973. PLURONIC FT L 61s are also known by their trade name PLURONIC FT L 61s. Concentrated PLURONIC FT L 61 solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial PLURONIC FT L 61 407 have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery. Solutions of PLURONIC FT L 61 407 (∼25%) are viscous liquids below 25 °C; at body temperature PLURONIC FT L 61s form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of PLURONIC FT L 61 407 in cell delivery systems. Introduction of the carbonate linkage between PLURONIC FT L 61 ‘blocks’ and linking of PLURONIC FT L 61s into structures of a higher molecular mass118 PLURONIC FT L 61 were attempted to overcome these disadvantages. PLURONIC FT L 61 is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO). PLURONIC FT L 61s and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders. Another important property of PLURONIC FT L 61s is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures. Certain PLURONIC FT L 61s such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression. Certain PLURONIC FT L 61s, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa. An important characteristic of PLURONIC FT L 61 solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of PLURONIC FT L 61s are liquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in these systems depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. Different phase diagrams characterizing all these transitions have been constructed for most PLURONIC FT L 61s using a great variety of experimental techniques. In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. PLURONIC FT L 61s also clean the skin and hair by helping water to mix with oil and dirt so that PLURONIC FT L 61s can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. PLURONIC FT L 61s are polyoxyethlyene, polyoxypropylene block polymers. The impurities of commercial grade PLURONIC FT L 61 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and residual ethylene oxide and propylene oxide. Most PLURONIC FT L 61s function in cosmetics as surfactants, emulsifying agents, cleansing agents, and/or solubilizing agents, and are used in 141 cosmetic products at concentrations from 0.005% to 20%. PLURONIC FT L 61s injected intravenously in animals are rapidly excreted in the urine, with some accumulation in lung, liver, brain, and kidney tissue. In humans, the plasma concentration of PLURONIC FT L 61 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘PLURONIC FT L 61’ was coined by the inventor, Irving Schmolka, who received the patent for PLURONIC FT L 61s in 1973. PLURONIC FT L 61s are also known by their trade name PLURONIC FT L 61s. Concentrated PLURONIC FT L 61 solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial PLURONIC FT L 61 407 have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery. Solutions of PLURONIC FT L 61 407 (∼25%) are viscous liquids below 25 °C; at body temperature PLURONIC FT L 61s form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of PLURONIC FT L 61 407 in cell delivery systems. Introduction of the carbonate linkage between PLURONIC FT L 61 ‘blocks’ and linking of PLURONIC FT L 61s into structures of a higher molecular mass118 PLURONIC FT L 61 were attempted to overcome these disadvantages. PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.PLURONIC FT L 61 is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO). Formulation and characterization of PLURONIC FT L 61 thermoreversible gel containing polymeric microparticles and hyaluronic acid. PLURONIC FT L 61s are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. PLURONIC FT L 61 is composed of triblock copolymers of polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61 as a nonionic surfactant, the synthetic polymer has been previously used in drug delivery and medical imaging applications PLURONIC FT L 61 sol-gel reversible hydrogels have attracted the attention for practical biomedical and pharmaceutical applications because of constituents solubility, biocompatibility with biological systems and easy administration of pharmaceutical formulations. The pharmaceutical and biomedical fields covered by the use of PLURONIC FT L 61s including solubilization of hydrophobic drugs, controlled release, biomacromolecule delivery (e.g., proteins and genes) and tissue engineering. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. PLURONIC FT L 61s also clean the skin and hair by helping water to mix with oil and dirt so that PLURONIC FT L 61s can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. PLURONIC FT L 61 with its synonym as polyethylene-propylene glycol copolymer and trade names as Supronic, PLURONIC FT L 61 or Tetronic have been introduced in 1950 as a non-ionic triblock copolymer. Assessment of PLURONIC FT L 61s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, and PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, and PLURONIC FT L 61 182 Dibenzoate as Used in Cosmetics. They were since then very famously used in diverse pharmaceutical applications. Chemically PLURONIC FT L 61 is α-Hydro-ω-hydroxypoly (oxyethylene)a poly (oxypropylene)b poly (oxyethylene)a block copolymer and they consisted of two hydrophilic chains of ethylene oxide chains (PEO) that sandwiched one hydrophobic propylene oxide chain (PPO) giving a chemical formula HO(C2H4O)a(C3H6O)b(C2H4O)aH where a and b have the values as shown in the Table 1. The varying length of polymer blocks giving rise to different polymers identified as PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 and PLURONIC FT L 61 407 showing a slight difference in their properties. Most applications involve the use of PLURONIC FT L 61 P407 and include delivery of protein/peptide drugs [25], such as insulin [26], interleukin-2 [27], epidermal growth factor [28], bone morphogenic protein [29], fibroblastic growth factor, and endothelial cell growth factor [30]. Surfactants play an important role in stabilizing proteins in liquid formulations against aggregate/particle formation during processing, handling, storage, and transportation. Only 3 surfactants are currently used in marketed therapeutic protein formulations: polysorbate 20, polysorbate 80, and PLURONIC FT L 61 188. While polysorbates are the most widely used surfactants, their intrinsic oxidative and hydrolytic degradation issues highlights the importance of alternative surfactants such as PLURONIC FT L 61 188. Here, we compare polysorbates and PLURONIC FT L 61 188 with regards to their stabilizing properties under various stress and storage conditions for several monoclonal antibody formulations. Our data shows that PLURONIC FT L 61 188 can provide suitable protection of monoclonal antibodies against interfacial stress in liquid formulations in vials. However, visible protein-polydimethylsiloxane (PDMS; silicone oil) particles were observed in vials after long-term storage at 2-8°C for some protein formulations using PLURONIC FT L 61 188, which were not observed in polysorbate formulations. The occurrence of these protein-PDMS particles in PLURONIC FT L 61 188 formulations is a protein-specific phenomenon that may correlate with protein physico-chemical properties. In this study, the primary source of the PDMS in particles found in vials was considered to be from the primary packaging stoppers used. Our findings highlight benefits, but also risks associated with using PLURONIC FT L 61 188 in liquid biotherapeutic formulations. PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.
PLURONIC PE 6400
Nonionic surfactants, which are favored in topical formulations because they have less potential for skin irritancy compared with ionic surfactants, and certain solvents alter the emulsions coating hair/wool, thereby allowing more drug to reach the skin surface.
Pluronic PE 6400 is postulated that the mechanism by which skin penetration enhancers increase drug transport across the skin involves increasing the fluidity and/or the hydration of the polar head groups of the lipid bilayers.

CAS: 68213-23-0
MF: C12H25O(CH2CH2O)9H
MW: 0
EINECS: 500-201-8

General rule that the solubility of Pluronic PE types in water increases in step with the proportion of polyethylene glycol they contain.
If two products contain the same mass fraction of Pluronic PE 6400, the molar mass of the polypropylene glycol block is the determining factor, and the one with the lower molar mass will be the more soluble.
Pluronic PE 6400 is a 100% active, low-foaming, nonionic surfactant.
Pluronic PE 6400 is block copolymers in which the central polypropylene glycol group is flanked by two polyethylene glycol groups.
Pluronic PE 6400 perform well as dispersing agents and emulsifiers.

Pluronic PE 6400 supplied in liquid, paste, solid, or powder form, depending on their degree of ethoxylation.
Pluronic PE 6400 can be employed in a very wide variety of applicationssuch asdefoamers in sugar refining, wetting agents in agro chemical formulations, and as lubricants in metalworking fluids.
Pluronic PE 6400 has strong leveling, slow-dyeing, permeability and diffusibility for various dyes.
Pluronic PE 6400 has the ability to assist in scouring and can be used with various surfactants and dyes.
Pluronic PE 6400 is resistant to acid, alkali, hard water, heat and heavy metal salts.

Physical form(25 °C): Liquid
Viscosity (23 ℃, Brookfield)[mPa•s]: approx. 1000
pH (5% in water ): 7
Cloud point (water) [° C]: 60
Surface tension(DIN 53914, 1 g/l, 23 °C)[mN/m]: approx. 41
Density (g/cm3): approx. 1.05

Applications:
Pluronic PE 6400 is leveling agent and retarding agent for printing and dyeing industry, which can improve scouring and color fastness,
Formulate detergent for metal processing,
Used as lubricant emulsifier in glass fiber industry,
Used as a seed soaking penetrant in agriculture to increase the germination rate of seeds.
Used as an emulsifier in other industries.
Pluronic PE 6400 has the highest detergency of all the products in the Pluronic PE range, and it is low-foaming.
Pluronic PE 6400 performs particularly well in applications that involve intensive mechanical action, i.e. in dishwashers and industrial bottle-washing machines.
Pluronic PE 6400 can also be used in dairy cleaners.
Other areas of application include cutting and grinding fluids for metal, where Pluronic PE 6400 acts as a lubricant and coolant.

Pluronic PE 6400 content and the molar mass of the central polypropylene glycol block of surfactants of this type can be varied within wide limits, and the result is that they are exceptionally versatile.
Pluronic PE 6400 types can be tailored to boost their wetting, dispersing or emulsifying properties as the situation requires.
Pluronic PE 6400 can be used to reduce foam or eliminate it altogether, and they can be used as solubilizers and thickeners.
Pluronic PE 6400 ability to act as impregnating agents, humectants, plasticizers and lubricants can be exploited in a variety of situations.
Pluronic PE 6400 can be used to adjust the viscosity of other liquids, to make tacky substances more coherent, and to disperse suspended solids.
Pluronic PE 6400 can also be employed as heat transfer fluids and hydraulic fluids in some applications.
Pluronic PE 6400 can be used in detergents and cleaners in the dairy, brewery and soft drinks sectors, for instance, in cleaners that are sprayed onto metal components to remove shavings and swarf, in the rubber and plastics industries, and in other branches of industry.

Synonyms
Alcohols, C12-18, ethoxylated
68213-23-0
(C12-C18) Alkyl alcohol ethoxylate
500-201-8
C12-18 Alkyl alcohol ethoxylate
DTXSID5041934
EC 500-201-8
Ethoxylated C12-18 alcohols
Poly(oxy-1,2-ethanediyl), alpha-(C12-C18) alkyl-omega-hydroxy-
PMDETA – Pentamethyldiethylenetriamine
SYNONYMS N-[2-(dimethylamino)ethyl]-N,N',N'-trimethyl 1,2-ethanediamine;1,1,4,7,7-Pentamethyldiethylenetriamine; Bis(2-dimethylaminoethyl)methylamine; N,N,N',N',N''-Pentamethyldiethylenetriamine; Bis(2-dimetilaminoetil)(metil)amina; CAS NO:3030-47-5
p-Methylaminophenol sulfate
SYNONYMS p-Methylaminophenol sulfate; Paramethylaminophenol sulfate; Metol; 4-(Methylamino)phenol sulfate salt (2:1); p-Methylaminophenol sulfate; Armol; Elon; Genol; Graphol; Metatyl; Methyl-p-aminophenol sulfate; N-Methyl-4-hydroxyaniline hemisulfate; N-Methyl-p-aminophenol sulfate; p-(Methylamino)phenol sulfate salt (2:1); Photol; Pictol; Planetol; Rhodol; Verol; p-Methylaminophenol sulfate; Bis(4-hydroxy-N-methylanilinium) sulphate; CAS NO. 55-55-0 (hemisulfate) 1936-57-8 (sulfate) 150-75-4 (parent)
P-N-Propylbenzaldehyde
4-propyl benzaldehyde; benzaldehyde, 4-propyl-; p- propyl benzaldehyde; para- propyl benzaldehyde cas no: 28785-06-0
P-N-Propylbenzaldehyde
benzaldehyde, 4-propyl-; benzaldehyde, p-propyl-; p- propyl benzaldehyde; para- propyl benzaldehyde; 4- propylbenzaldehyde; 4-N- propylbenzaldehyde; p- propylbenzaldehyde; para- propylbenzaldehyde cas no :28785-06-0
POLAXAMER
Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word poloxamer was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.Poloxamers are also known by the trade names Synperonics,Pluronic,and Kolliphor.Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. For the generic term poloxamer, these copolymers are commonly named with the letter P (for poloxamer) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = poloxamer with a polyoxypropylene molecular mass of 4000 g/mo} and a 70% polyoxyethylene content). For the Pluronic and Synperonic tradenames, coding of these copolymers starts with a letter to define its physical form at room temperature (L = liquid, P = paste, F = flake (solid)) followed by two or three digits, The first digit (two digits in a three-digit number) in the numerical designation, multiplied by 300, indicates the approximate molecular weight of the hydrophobe; and the last digit x 10 gives the percentage polyoxyethylene content (e.g., L61 indicates a polyoxypropylene molecular mass of 1800 g/mol and a 10% polyoxyethylene content). In the example given, poloxamer 181 (P181) = Pluronic L61 and Synperonic PE/L 61.An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in these systems depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio).The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. Different phase diagrams characterizing all these transitions have been constructed for most poloxamers using a great variety of experimental techniques (e.g. SAXS, Differential scanning calorimetry, viscosity measurements, light scattering).In bioprocess applications, poloxamers are used in cell culture media for their cell cushioning effects because their addition leads to less stressful shear conditions for cells in reactors.In materials science, the poloxamer P123 has recently been used in the synthesis of mesoporous materials, including SBA-15.When mixed with water, concentrated solutions of poloxamers can form hydrogels. These gels can be extruded easily, acting as a carrier for other particles, and used for robocasting.Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting. The poloxamers have been shown to incorporate into cellular membranes affecting the microviscosity of the membranes. The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle.Poloxamers have been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells. Poloxamers have also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin.The poloxamers have also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles.Certain poloxamers such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression. Certain poloxamers, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa.Wang et al. reported that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells. Moreover, toxicity correlated with the sonolytic degradation of the polymers.Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units.This particular compound is also known by the BASF trade name Pluronic F-127 or by the Croda trade name Synperonic PE/F 127.Most of the common uses of poloxamer 407 are related to its surfactant properties. For example, it is widely used in cosmetics for dissolving oily ingredients in water. It can also be found in multi-purpose contact lens cleaning solutions, where its purpose there is to help remove lipid films from the lens. It can also be found in some mouthwashes. There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically.Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties.In a 30% solution by weight, poloxamer 407 forms a gel solid at room temperature but liquifies when chilled to 4 °C (39 °F). This allows poloxamer 407 to serve as a removable support material, particularly for creating hollow channels or cavities inside hydrogels.In this role, it is often referred to as a "sacrificial ink" or a "fugitive ink".They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.Wang et al. reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can become highly toxic to cultured cells. The toxicity correlated with the sonolytic degradation of the polymers.Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘poloxamer’ was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973. Poloxamers are also known by their trade name Pluronics” .Concentrated poloxamer solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial poloxamer 407 (Pluronic® F127) have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery.Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure. Poloxamer 407 (Pluronic® F127, PEO99–PPO67–PEO99) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25°C at a concentration of 20 wt%.Like PNIPAAm polymers, much effort has been made to synthesize chemically crosslinkable poloxamers to equip them with enhanced mechanical properties.Solutions of poloxamer 407 (∼25%) are viscous liquids below 25 °C; at body temperature they form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of poloxamer 407 in cell delivery systems. Introduction of the carbonate linkage between poloxamer ‘blocks’ and linking of poloxamers into structures of a higher molecular mass118 were attempted to overcome these disadvantages. However, only more sophisticated synthetic procedures offering graft copolymers hold promise for the application as injectable cell carriers.While the physically crosslinked gels display a compressive modulus of 142.5 ± 29.7 KPa, radically crosslinked gels using the methacrylated poloxamer and ammonium persulfate (APS) as a thermal initiator are three times stiffer, displaying a compressive modulus of 415 ± 45.7 KPa.Lysozyme has been utilized as a model protein to test the protein release profile of the diacrylated poloxamer hydrogels with higher mechanical properties. These poloxamers instantaneously formed a semi–solidified physical gel when the temperature was increased above the LCST. Then these poloxamers underwent photocrosslinking initiated by pre–mixed (4–Benzoylbenzyl)trimethylammonium chloride with UV exposure. Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32.It is more commonly called Pluronic® (BASF). Since the middle block is hydrophobic and the two end blocks are hydrophilic, the poloxamer behaves as polymer surfactant. It is used as nonionic polymer surfactant. They can function as antifoaming agents, wetting agents, dispersants, thickeners, and emulsifiers.Poloxamers are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios.Another important property of Poloxamers is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures. It is for this reason that the Poloxamer 407 phase transitions and the effect of hydroxypropyl β-cyclodextrin (HP β–CD) on them were studied using acoustic spectroscopy with purpose of verifying the relevance of this method in the pharmaceutical field .These works introduced here are just a small fraction of a large number of studies on poloxamers. One of the reasons why poloxamers have been investigated by SANS is its variety of phase behavior, applications, particularly to bioengineering field. Since there are many variations in poloxamer with different numbers of x, y, and z in spite of its simple structure , there still remain a large number of studies on poloxamer with SANS.As the first step, the hydrodynamic diameter of the micelles of Poloxamer 407 in the concentration range of 3–25% (w/v) was investigated by measuring the attenuation and propagation velocity of ultrasound at different temperatures.Then the effect of the addition of HP β-CD on the Poloxamer 407 water systems was monitored by adding different amounts [5–20% (w/v)] of HP β–CD, which is widely used in oral and parenteral pharmaceutical dosage forms since it increases the stability and solubility or poorly water-soluble drugs through the formation of inclusion complexes. Previous studies had demonstrated that the addition of different glycols and polyalcohols, as well as the addition of HP β–CD, influenced both the gelation and micellization temperature of Poloxamer 407, outlining a shift of this parameter towards higher values. In this case, acoustic spectroscopy allowed a better characterization of the microstructure and behaviour of these systems at increasing temperatures.The positive thermoresponsive materials turn to gel above the upper critical solution temperature (USCT), which depends on the polymer structure, such as poloxamer, hydroxypropylcellulose, or methylcellulose.The value of modulus G′ for Poloxamer 407 decreases during micellization until it reaches a plateau. This trend is more evident in concentrated systems, but is practically not detectable for the dilute ones. For the 17.5% and 20% samples, it is also possible to identify a slight inflexion after the plateau, which may be identified with the sol/gel transition since the corresponding values of the temperature are in agreement with those determined rheologically and by thermal analysis.The poloxamers, also known by the trademark Pluronic, Synperonic and Tetronic, were initially introduced between 1950 and have presented several pharmaceutical applications, as well as, excellent compatibility with other compounds.Studies showed some of the poloxamer’s characteristics, especially thermoresponsiveness, high capacity to solubilize drugs, good drug release characteristics, and absence of toxicity in mucosal membranes, and thus widely recognized in the pharmaceutical area as a safe material.Poloxamers are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide.The poloxamer 407 or Pluronic F127 has particularly interest because of the thermoreversible properties, and can be useful in the optimization of drug delivery systems, and employed in many formulations like intravenous preparations, topical, ophthalmic, nasal, vaginal, and rectal, with no irritation or skin sensitivity.Poloxamer 407 aqueous solutions have the property of being a thermoresponsive system, which leads to a sol–gel transition due to temperature increase.The advantages of poloxamers in liquid pharmaceutical forms are especially because that they allow a comfortable release at the action site, gelling at the site and may have modified release.Aqueous solutions of Poloxamer or Pluronic undergo sol-to-gel transition as the temperature increases. However, the implanted gel of Poloxamer is quickly eroded and does not persist for more than a few days at most. To improve the system, end-group modified Poloxamers, and multiblock co-polymers consisting of Poloxamer and biodegradable polymers have been developed. In addition, random multiblock copolymers consisting of PEG, PPG, and a biodegradable polymer were reported.Even though modification of the hydroxyl end groups of Poloxamer by oligolactides (LA6) and oligocaprolactones (CL6) increases hydrophobicity of the polymer, the sol-to-gel transition temperature and critical gel concentration increased, compared with the unmodified Poloxamer.Poloxamer aqueous solution is driven by the unimer-to-micelle transition, followed by packing of the micelles. The oligolactide and oligocaprolactone partition into the PPG micelle core and disturb the integrity and density of the original micelles of the unmodified Poloxamer.Poloxamer. Thus, the micelle packing mechanism for the sol-to-gel transition is interfered with. Poloxamer (F127) was modified by oligolactide (LA8 or LA18), and was then reacted with succinic anhydrides to prepare a carboxylic acid end-capped Poloxamer. The polymer showed sol-gel transition in a pH/temperature dependent manner. The ionization of carboxylic acid and the decrease in solubility of PEG at high pH were suggested to explain the phase behavior.34,35 L-dihydroxyphenyalanine end-capped Poloxamer (F127) showed an increase in bioadhesion between the polymer and bovine mucin, an increase in the sol-to-gel transition temperature.Multiblock copolymers were prepared to improve gel properties such as gel duration and biodegradation. Poloxamers (F127) were coupled by hexa-methylene diisocyanate to prepare multiblock Poloxamer.37 The drug release rate from the multiblock Poloxamer hydrogel was slower than from the unmodified Poloxamer hydrogel. PEG/PPG alternating multiblock copolymers showing thermogelling were reported.Poloxamer was coupled by terephthalic anhydride to introduce the biodegradability as well as pH sensitivity.35 Poloxamer was also coupled by disulfide to show glutathione sensitive degradation and drug release.44 In addition, Poloxamer was end capped by l-oligolactide or d-oligolactide, then coupled to prepare the multiblock Poloxamer containing PLA. By mixing the l-isomer and d-isomer containing multiblock Poloxamer, a stereocomplex showing thermal gelation was prepared.Pluronics, also known as poloxamers, are a class of synthetic block copolymers which consist of hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(propylene oxide) (PPO), arranged in an A-B-A triblock structure, thus giving PEO-PPO-PEO.Poloxamer 407 in conjuction with HPMC has been used for rectal delivery of quinine in children.Use of poloxamer 188 as a membrane sealant on in vitro studies of cardiac myocytes showed signs of possible prevention of cardiomyopathy and heart failure in muscular dystrophy.A combination of poloxamer 407, poloxamer 188 and carbopol was utilized as an ophthalmic delivery system for puerarin, thus providing an alternative for longer-lasting drug availability to the precorneal area.Poloxamer 407 has also shown prolonged duration of the painkiller, lidocaine, at the injection site as well as sustained drug release and increased therapeutic efficacy.In the absence of interfering compounds, polymers of the poloxamer type can sometimes be determined by reversed-phase HPLC with methanol, but the most common separation technique is SEC.There are many commercialized copolymers, such as Pluronics, Poloxamers, and Tetronics, which are comprised of PEO–PPO sequences. Poloxamers, nonionic polymers polyoxyethylene–polyoxypropylene–polyoxyethylene (PEOn–PPOn–PEOn), are commonly used in pharmaceutical application in drug delivery.This review article focuses on thermoresponsive hydrogels consisting of poloxamers which are of high interest for biomedical application especially in drug delivery for ophthalmic, injectable, transdermal, and vaginal administration. These hydrogels remain fluid at room temperature but become more viscous gel once they are exposed to body temperature. In this way, the gelling system remains at the topical level for a long time and the drug release is controlled and prolonged. Poloxamers are synthetic triblock copolymers of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), also commercially known as Pluronics®, Synperonics® or Lutrol®. The different poloxamers cover a range of liquids, pastes, and solids, with molecular weights and ethylene oxide–propylene oxide weight ratios varying from 1100 to 14,000 and 1:9 to 8:2, respectively. Concentrated aqueous solutions of poloxamers form thermoreversible gels. In recent years this type of gel has arouse interest for tissue engineering. Finally, the use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC). This property is exploited for drug delivery and different therapeutic applications.“Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘poloxamer’ was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973. Poloxamers are also known by their trade name Pluronics”.Concentrated poloxamer solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial poloxamer 407 (Pluronic® F127) have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery.6 Pluronic® F127 is generally accepted as safe, although in animal studies injection of doses exceeding 27.5 mg kg− 1116,117 caused serious increases in blood cholesterol and triglycerides.Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure. Poloxamer 407 (Pluronic® F127, PEO99–PPO67–PEO99) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25°C at a concentration of 20 wt%. However, its applications are greatly limited by its poor mechanical properties resulting from the purely physical crosslinking. These gels are characterized by low viscosity and very high permeabilities. Moreover, while they instantaneously gel upon increasing temperature above LCST in the body, they lose their structural integrity when mixed with aqueous solutions, which makes them unfit for drug delivery purposes. Like PNIPAAm polymers, much effort has been made to synthesize chemically crosslinkable poloxamers to equip them with enhanced mechanical properties. However, due to their chemical structure, reactive groups are only available at chain ends, therefore, chemically cross–linkable groups can only be used to end–cap the triblock chain. There are two main types of crosslinkable end–capping groups: methacrylate/acrylate and ethoxylsilane. Methacrylates/acrylates can be coupled to the polymer by reacting methacryloyl chloride/acryloyl chloride with the hydroxyl groups on both ends. Similarly, (3–isocyanato–propyl)triethoxysilane can be employed to react with the hydroxyl groups under catalysis of 2–ethyl–hexanoate to introduce ethoxysilane end–capping groups. While the physically crosslinked gels display a compressive modulus of 142.5 ± 29.7 KPa, radically crosslinked gels using the methacrylated poloxamer and ammonium persulfate (APS) as a thermal initiator are three times stiffer, displaying a compressive modulus of 415 ± 45.7 KPa. Although the exthoxysilane causes gradual chemical crosslinking (same mechanism as crosslinking of trimethoxysilane–grafted PNIPAAm–based hydrogels), their crosslinking resulted in a much higher compressive modulus: ~2600 KPa after 17 days. Lysozyme has been utilized as a model protein to test the protein release profile of the diacrylated poloxamer hydrogels with higher mechanical properties. These poloxamers instantaneously formed a semi–solidified physical gel when the temperature was increased above the LCST. Then these poloxamers underwent photocrosslinking initiated by pre–mixed (4–Benzoylbenzyl)trimethylammonium chloride with UV exposure. With photocrosslinking, the gels maintained their structural integrity up to one month. While burst release of 50–70 wt% lysozyme was observed from the hydrogels in the first seven days, the remaining 30–50 wt% protein was released in a more sustained profile over a one–month period.Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32.Poloxamers are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules whose self-assembling properties display a wide range of phase behavior. This ability to form micelles and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC).Another important property of Poloxamers is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures. This sol/gel transition have been correlated to the intrinsic changes in the micelle properties, or to the entropic variation in the ordered water molecules close to the PPO segments, or to the possibility of formation of a cross-linked and three-dimensional structure able to entrap water in this network. Neutron scattering studies have demonstrated the formation of a gel structure for a micelle concentration reaching the critical volume fraction of 0.53, which allows locking of the micelles in a hard-sphere, crystalline structure due to their high volume density.Both micellization and gelation depend on different factors: temperature, polymer concentration, and PEO block length.It is for this reason that the Poloxamer 407 phase transitions and the effect of hydroxypropyl β-cyclodextrin (HP β–CD) on them were studied using acoustic spectroscopy with purpose of verifying the relevance of this method in the pharmaceutical field.The poloxamers, also known by the trademark Pluronic, Synperonic and Tetronic, were initially introduced between 1950 and have presented several pharmaceutical applications, as well as, excellent compatibility with other compounds.Studies showed some of the poloxamer’s characteristics, especially thermoresponsiveness, high capacity to solubilize drugs, good drug release characteristics, and absence of toxicity in mucosal membranes, and thus widely recognized in the pharmaceutical area as a safe material.Poloxamers are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide (PO) (OEx–POy–OEx). They are synthesized by polymerization of EO and PO units, in sequence, also in the presence of sodium hydroxide and potassium hydroxide. Poloxamers compounds have the chemical formula HO[CH2CH2O] x[CH(CH3)CH2O] y[CH2CH2O]OH, where y is greater than 14.According to the ratio between hydrophilic (EO) and lipophilic (PO) units, various copolymers block and size can be obtained within different molecular weights and physic-chemical properties .The poloxamer 407 or Pluronic F127 has particularly interest because of the thermoreversible properties, and can be useful in the optimization of drug delivery systems, and employed in many formulations like intravenous preparations, topical, ophthalmic, nasal, vaginal, and rectal, with no irritation or skin sensitivity.Poloxamer 407 aqueous solutions have the property of being a thermoresponsive system, which leads to a sol–gel transition due to temperature increase. When in aqueous dispersions, the individual molecules of the copolymer’s block of P407 self-organize into micelles (micellization), when are in concentrations above the critical micelle concentration (CMC) in order to minimize the free energy from the solution. These micelles can be spherical, cylindrical, or lamellar, depending upon the length in the chain, containing EO and PB, the concentration of polymer and temperature, that leads to increased viscosity.The advantages of poloxamers in liquid pharmaceutical forms are especially because that they allow a comfortable release at the action site, gelling at the site and may have modified release. The disadvantages of these polymers are weak mucoadhesive, and poor mechanical properties, short residence time due to easily dissolution at the action site .Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermoreversible properties, which is of the utmost interest in optimising drug formulation (fluid state at room temperature facilitating administration and gel state above sol–gel transition temperature at body temperature promoting prolonged release of pharmacological agents). Pharmaceutical evaluation consists in determining the rheological behaviour (flow curve or oscillatory studies), sol–gel transition temperature, in vitro drug release using either synthetic or physiological membrane and (bio)adhesion characteristics. Poloxamer 407 formulations led to enhanced solubilisation of poorly water-soluble drugs and prolonged release profile for many galenic applications (e.g., oral, rectal, topical, ophthalmic, nasal and injectable preparations) but did not clearly show any relevant advantages when used alone. Combination with other excipients like Poloxamer 188 or mucoadhesive polymers promotes Poloxamer 407 action by optimising sol–gel transition temperature or increasing bioadhesive properties. Inclusion of liposomes or micro(nano)particles in Poloxamer 407 formulations offers interesting prospects, as well. Besides these promising data, Poloxamer 407 has been held responsible for lipidic profile alteration and possible renal toxicity, which compromises its development for parenteral applications. In addition, new findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.
POLIVINIL PROLIDON - PVP K 30
SYNONYMS K-30;POVIDONE;POP;POLYVINYLPYRROLIDONE K 25;POLYVINYLPYRROLIDONE K 30;POLYVINYLPYRROLIDONE K 90;POLYVINYLPYRROLIDONE K 60;POLYVINYLPYRROLIDONE-DIVERGAN RS CAS NO:9003-39-8
POLIVINYL PYRROLIDONE-30 (LUVISKOL K 30 )
Polyvinylpyrrolidone; poly(1-vinylpyrrolidinone); polyvinylpyrrolidone; povidone; N- vinylpyrrolidone polymer; PVP K 90; PVP, Povidone; PVPP, Crospovidone, Polyvidone; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer ; 1-Vinyl-2-pyrrolidinon-Polymere cas no: 9003-39-8
POLIVINYL PYRROLIDONE-90 (LUVISKOL K 90 )
cas no 9002-88-4 Ethene, homopolymer; polyetylene;
POLİAKRİLAT
SYNONYMS Poly(sodium acrylate), Sodium polyacrylate;Poly(acrylic acid), sodium salt;Polyacrylate sodium salt;Polyacrylic acid, sodium salt;Sodium poly acrylate;poly(sodium acrylate) macromolecule;poly(sodiumacrylate);polysodiumacrylate CAS NO:9003-04-7
Polietilen Wax
SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6
POLİKUATERNIUM 6
Saç ürünlerinde kullanılan, alkolde çözünebilen kondisyoner. Saç bakım solüsyonlarında, el kremi formülasyonlarında kondisyoner ve antistatik etki için kullanılır. Anyonikler ile uyumlu değildir. Alkol içeren formülasyonlarda kullanılabilir
POLİKUATERNİUM 10
Şampuan ve vücut kremlerinde kullanılan suda çözünebilen katyonik kondisyoner.Yıpranmış saçların korunmasında ve güçlendirilmesinde etkilidir
POLİKUATERNİUM 7
Saç ürünlerinde kullanılan suda çözünebilen kondisyoner.Şampuan, sıvı sabun, el kremi formülasyonlarında kondisyoner, köpük stabilizasyonu ve antistatik etki için kullanılır
POLİSORBAT 20
Emülgatör. Su/yağ fazlarının emülsiyonun oluşmasını sağlamak için krem, losyon ve şampuan üretiminde kullanılır
POLİSORBAT 20 - 60 -80
SYNONYMS Tween® 60;POE (20) sorbitan monostearate; Polysorbate 60; Polyoxyethylene Sorbitan Monostearate; CAS NO:9005-67-8
Politetrametileneterglikol (PTMEG)
SYNONYMS Poly(tetrahydrofuran); PTMEG; PTMG; CAS NO:25190-06-1
POLOXAMER
Poloxamer is nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)).


CAS Number: 106392-12-5
EC Number: 923-642-1



Poloxamer is nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene.
Poloxamer is nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)).


The word Poloxamer was coined by BASF inventor, Irving Schmolka, who received the patent for these materials in 1973.
Poloxamer is also known by the trade names Pluronic, Kolliphor (pharma grade), and Synperonic.
Because the lengths of the polymer blocks can be customized, many different Poloxamer exists that have slightly different properties.


For the generic term Poloxamer, these copolymers are commonly named with the letter P (for Poloxamer) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = Poloxamer with a polyoxypropylene molecular mass of 4000 g/mol and a 70% polyoxyethylene content).


Poloxamer is also known as polyethylene- propylene glycol copolymer or polyoxvethylene-polyoxypropylene copolymer.
Poloxamer is a series of block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO).
All poloxamers are chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture.


The presence of PEO and PPO blocks in a single polymer chain imparts to the molecule amphiphilic properties whose self-assembling properties display a wide range of phase behaviour.
Several different types of poloxamers are commercially available whose physical and surface-active properties vary over a wide range.


Pharmacopoeial grades generally occur as white, waxy, granules or as solids.
They are practically odourless and tasteless.
Poloxamers are listed in pharmacopoeia and generally regarded as nontoxic and non-irritant.


Included in the FDA Inactive Ingredients Database (IV injections; inhalations, ophthalmic preparations; oral powders. solutions, suspensions, and syrups; topical preparations).
Poloxamer is nonionic triblock copolymers consisting of a central hydrophobic polyoxypropylene chain surrounded by two hydrophilic polyoxyethylene chains.


Poloxamer is nonionic polyoxyethylene-polyoxypropylene polymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.
The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic.



USES and APPLICATIONS of POLOXAMER:
Because of their amphiphilic structures, Poloxamer has surfactant properties that make them useful in industrial applications.
Among other things, Poloxamer can be used to increase the water solubility of hydrophobic, oily substances or otherwise increase the miscibility of two substances with different hydrophobicities.
For this reason, Poloxamer is commonly used in industrial applications, cosmetics, and pharmaceuticals.


Poloxamer has also been evaluated for various drug delivery applications and were shown to sensitize drug-resistant cancers to chemotherapy.
In bioprocess applications, Poloxamer is used in cell culture media for their cell cushioning effects because their addition leads to less stressful shear conditions for cells in reactors.


There are grades of Poloxamer commercially available specifically for cell culture, including Kolliphor P 188 Bio.
In materials science, the Poloxamer has recently been used in the synthesis of mesoporous materials, including SBA-15.
When mixed with water, concentrated solutions of Poloxamer can form hydrogels.


These gels can be extruded easily, acting as a carrier for other particles, and used for robocasting.
The main uses of Poloxamer is as dispersing agents, emulsifying agents, solubilizing agents, tablet lubricants, wetting agents and foaming agents.
As nonionic polyoxyethylene-polyoxypropylene copolymers, Poloxamer is used as emulsifying or solubilizing agents.


Poloxamer is used as emulsifying agents in intravenous fat emulsions and as solubilizing and stabilizing agents to maintain clarity of elixirs and syrups.
Poloxamer can also be used as wetting agents; in ointments, suppository bases, and gels; and in tablet binders and coatings. Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems.


More recently, poloxamers have found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as dantron.


Poloxamer may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer is used in the cosmetics field as oil-in-water emulsifiers, cleansers for mild facial products, and dispersing agents.
Nowadays, Poloxamer is widely used in different drug delivery systems due to its biodegradability, high solubility and low toxicity.


Poloxamer contains both hydrophilic and hydrophobic moieties, so they are widely used as surfactants and emulsifiers in formulation.
Poloxamer is used as a solubility enhancer in solid dispersion.
Pluronic grade has thermo-reversible gelation property, transforming into liquid at room temperature and gel at body temperature, hence used in control release formulation.


Poloxamer is used to improve the stability of Nanoparticle and liposome.
Poloxamer is used in solid suppositories to improve the dissolution of poorly soluble drugs and reduce rectal irritation compared to traditional polymer such as polyethylene glycol.


Poloxamer is also used as a stabilizer in biological.
Medicines that contain poloxamer: Coloxyl Drops
All of the poloxamer is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture.


Their physical and surface-active properties vary over a wide range and a number of different types are commercially available.
Poloxamer is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups.


Poloxamer may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems.


More recently, poloxamers have found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron.
Poloxamer may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.


Poloxamer is a type of non-ionic surfactant that is used as an emulsifier, stabilizer, and thickening agent in a variety of products, including dietary supplements.
Poloxamer is also used as a lubricant in some medical and pharmaceutical products.



HOW IS POLOXAMER USED IN THE FOOD INDUSTRY?
Poloxamer is a type of dietary supplement that is used in the food industry as an emulsifier, stabilizer, and thickening agent.
Poloxamer is used to improve the texture, stability, and shelf life of food products.
Poloxamer is also used to reduce fat and sugar content in food products, as well as to improve the flavor and texture of processed foods.



WHY IS POLOXAMER USED?
Poloxamer helps to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent
Substances, usually liquids, Poloxamer is used to dissolve other substances.
Poloxamer also clean the skin and hair by helping water to mix with oil and dirt so that they can be rinsed away. Poloxamer 188 kills microorganisms, or prevents or inhibits their growth and reproduction.
Poloxamer 182 Dibenzoate acts as a lubricant on the skin’s surface, which gives the skin a soft and smooth appearance.



WHERE IS POLOXAMER USED?
Poloxamer is a type of dietary supplement that is used to treat a variety of conditions, including constipation, diarrhea, and irritable bowel syndrome.
Poloxamer is also used to reduce cholesterol levels and to treat certain types of infections.



ACTIVE INGREDIENT OF POLOXAMER:
The medicines below all contain the following active ingredient(s): poloxamer.
You can select a medicine from this list to find out more - including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS).



HEALTH BENEFITS OF POLOXAMER?
Poloxamer is a type of dietary supplement that has been found to have a number of health benefits.
Poloxamer has been shown to reduce inflammation, improve joint health, and reduce the risk of cardiovascular disease.
Poloxamer has also been found to help reduce cholesterol levels, improve digestion, and reduce the risk of certain types of cancer.
Additionally, Poloxamer has been found to help improve skin health, reduce the risk of diabetes, and improve overall immune system function.



BENEFITS AND CLAIMS OF POLOXAMER:
*Fast dispersion and rapid emulsification from large droplet to medium sized droplet.
*Hydrophilic coating of surfactant on oil droplets minimizes the lipid digestion.
*Formation of other secondary structures such as micelles, chylomicron in the GIT fluids which helps in drug absorption
*Non-digestible solubiliser to minimize drug precipitation in the GIT



POLOXAMER IS SUITABLE FOR:
*Cream / Emulsion
*Gel
*Softgel Capsules



BENEFITS OF POLOXAMER:
*Aqueous solution containing more than 20% Poloxamer concentration demonstrate themoreversible viscosity
*Clinically tested for mildness and are less irritating upon topical application
*Various grades available to suit different applications
*Poloxamer can be processed via hot melt extrusion (HME) or spray drying
*Poloxamer is applicable for oral, topical, or parenteral applications



MICELLIZATION AND PHASE TRANSITIONS OF POLOXAMER:
An important characteristic of Poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior.
Concentrated aqueous solutions of Poloxamer are liquid at low temperature and form a gel at higher temperature in a reversible process.
The transitions that occur in these systems depend on Poloxamer composition (molecular weight and hydrophilic/hydrophobic molar ratio).
At low temperatures and concentrations (below the critical micelle temperature and critical micelle concentration) individual block copolymers (unimers) are present in solution.

Above these values, aggregation of individual unimers occurs in a process called micellization.
This aggregation is driven by the dehydration of the hydrophobic polyoxypropylene block that becomes progressively less soluble as the polymer concentration or temperature increases.

The aggregation of several unimers occurs to minimize the interactions of the PPO blocks with the solvent.
Thus, the core of the aggregates is made from the insoluble blocks (polyoxypropylene) while the soluble portion (polyoxyethylene) forms the shell of the micelles.

The mechanisms on the micellization at equilibrium have shown to depend on two relaxation times:
(1) the first and fastest (tens of the microseconds scale) corresponds to the unimers exchange between micelles and the bulk solution and follows the Aniansson-Wall model (step-by-step insertion and expulsion of single polymer chains), and
(2) the second and much slower one (in the millisecond range) is attributed to the formation and breakdown of whole micellar units leading to the final micellar size equilibration.

Besides spherical micelles, elongated or worm-like micelles can also be formed.
The final geometry will depend on the entropy costs of stretching the blocks, which is directly related to their composition (size and polyoxypropylene/polyoxyethylene ratio).

The mechanisms involved in the shape transformation are different compared to the dynamics of micellization.
Two mechanisms were proposed for the sphere-to-rod transitions of block copolymer micelles, in which the micellar growth can occur by (A) fusion/fragmentation of micelles or (B) concomitant fusion/fragmentation of micelles and unimer exchange, followed by smoothing of the rod-like structures.

With higher increments of the temperature and/or concentration, other phenomena can occur such as the formation of highly ordered mesophases (cubic, hexagonal and lamellar).
Eventually, a complete dehydration of the polyoxypropylene blocks and the collapse of the polyoxyethylene chains will lead to clouding and/or macroscopic phase separation.

This is due to the fact that hydrogen bonding between the polyoxyethylene and the water molecules breaks down at high temperature and polyoxyethylene becomes also insoluble in water.
The phase transitions can also be largely influenced by the use of additives such as salts and alcohols.

The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in).
Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration.

Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration.
The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power.

Different phase diagrams characterizing all these transitions have been constructed for most poloxamers using a great variety of experimental techniques (e.g. SAXS, Differential scanning calorimetry, viscosity measurements, light scattering).



BIOLOGICAL EFFECT OF POLOXAMER:
Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting.
The Poloxamer has been shown to incorporate into cellular membranes affecting the microviscosity of the membranes.
The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle.

On multi drug resistant cancer cells:
Poloxamer has been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells.
Poloxamer has also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin.

Another effect of the polymers upon cancer cells is the inhibition of the production of ATP in multi-drug resistant (MDR) cancer cells.
The polymers seem to inhibit respiratory proteins I and IV, and the effect on respiration seems to be selective for MDR cancer cells, which may be explained by the difference in fuel sources between MDR and sensitive cells (fatty acids and glucose respectively).

Poloxamer has also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles.

On nuclear factor kappa B:
Certain Poloxamers such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression.
Certain poloxamers, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa.

Potential degradation by sonication:
Wang et al. reported that aqueous solutions of poloxamer 188 (Pluronic F-68) and poloxamer 407 (Pluronic F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells.
Moreover, toxicity correlated with the sonolytic degradation of the polymers.



ANY USEFUL TIPS OF POLOXAMER:
Naming of Poloxamer can be bewildering but typically, the nonproprietary name – poloxamer – is followed by a number: the first two digits of which, when multiplied by 100, correspond to the approximate average molecular weight of the polyoxypropylene portion of the copolymer and the third digit, when multiplied by 100, corresponds to the percentage by weight of the polyoxyethylene portion.

Similarly, with many of the trade names used for Poloxamer e.g. Kolliphor 188, the first digit arbitrarily represents the molecular weight of the polyoxypropylene portion and the second digit represents the weight percent of the oxyethylene portion.
The letters L, ‘P’, and ‘F’, stand for the physical form of the Poloxamer: liquid, paste, or flakes.

Although the USP-NF contains specifications for five poloxamer grades, many more different poloxamers are commercially available that vary in their molecular weight and the proportion of oxyethylene present in the polymer.
Some poloxamers (e.g Poloxamer 188) are incompatible with parabens.



WHAT IS POLOXAMER?
Poloxamers (Poloxamer 101, Poloxamer 105, Poloxamer 108, Poloxamer 122, Poloxamer 123, Poloxamer 124, Poloxamer 181, Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 185, Poloxamer 188, Poloxamer 212, Poloxamer 215, Poloxamer 217, Poloxamer 231, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 282, Poloxamer 284, Poloxamer 288, Poloxamer 331, Poloxamer 333, Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamer 401, Poloxamer 402, Poloxamer 403, Poloxamer 407, Poloxamer 105 Benzoate, Poloxamer 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene.

The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer
A naturally occurring or synthetic molecule made up of repeating units called monomers.
For example, the smallest polymer, Poloxamer 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene.

Poloxamers range from colorless liquids and pastes to white solids.
In cosmetics and personal care products, Poloxamer is used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.



PHYSICAL and CHEMICAL PROPERTIES of POLOXAMER:
Chemical Name: Poloxamer
CAS Registration Number: [9003-11-6]
Empirical Formula: HO(C2H4O)a(C3H6O)b(C2H4O)aH
Molecular weight: 2090 – 14 600 (average)
Regulatory Status: PhEur; USP-NF; JPE
Acidity/aikalinity: pH = 5.0—7.4 for a 2.5% w/v aqueous solution
Cloud point: > 100C for a 1% w/s aqueous solution, and a 10% w/v aqueous solution of poloxamer 188
HLB value: 0.5 – 30
Melting Point: 16oC for poloxamer 124; 52 – 57oC for poloxamer 188;
49oC for poloxamer 237; 57oC for poloxamer 338 and 52-57 oC for poloxamer 407
Solubilitiy: Solubility varies according to the poloxamer type
Surface tension: 19.8 mN/m for a 0.1% w/v aqueous poloxamer 188 solution at 25C;
24.0mN/m for a 0.01% w/w aqueous poloxamer 188 solution at 25C;
26.0 mN/m for a 0.001% w/v aqueous poloxamer solution at 25 C

Viscosity (dynamic): 1000 mPas as a melt at 77C for poloxamer 188
Physical state: liquid
Color: No data available
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available

Physical data:
HLB values:
Poloxamer 124: 12 - 18
Poloxamer 188, 338: > 24
Poloxamer 407: 18 - 23
Oxyethylene content (%):
Poloxamer 124: 44.8 - 48.6%
Poloxamer 188: 79.9 - 83.7%
Poloxamer 338: 81.4 - 84.9%
Poloxamer 407: 71.5 - 74.9%



FIRST AID MEASURES of POLOXAMER:
Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLOXAMER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of POLOXAMER:
-Extinguishing media:
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLOXAMER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
not required
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLOXAMER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of POLOXAMER:
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available

POLOXAMER 124
Poloxamer 124 is a polyoxyethylene, polyoxypropylene block polymer.
Poloxamer 124 is known for its ability to create a smooth, silky texture and its non-irritating and non-sensitizing properties.
The chemical formula of Poloxamer 124 is C5H10O2.


CAS Number: 9003-11-6
EC Number: 618-355-0
MDL Number: MFCD00082049
Chem/IUPAC Name: Oxirane, methyl-, polymer with oxirane (11;21)
Molecular Formula: C5H10O2



Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL, SYNPERONIC F 108, SYNPERONIC L 121, SYNPERONIC L 122, SYNPERONIC P 105, SYNPERONIC P 85, SYNPERONIC PE(R)/F68, SYNPERONIC PE(R)/L61, Polyethylene-Polypropylene Glycol, Pluronic L44 INH, Lutrol, Monolan, Pluronic, poloxalkol, poloxamera, polyethylene-propylene glycol copolymer, polyoxyethylene-polyoxypropylene copolymer, Supronic, Synperonic,



Poloxamer 124 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products.
This water-soluble polymer, Poloxamer 124, helps in emulsifying and stabilizing formulations, improving the texture, and enhancing the appearance of products.


Poloxamer 124 is a milky white paste or a colorless or almost colorless liquid.
Poloxamer 124 is soluble in water and in ethanol, practically insoluble in light petroleum.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.


Poloxamer 124 is a synthetic
Poloxamer 124 is a cGMP Pharmaceutical Grade Excipient and is the only monographed poloxamer that is liquid at room temperature − making it ideal for a broad range of dosage forms.


As a liquid amphiphilic polymer, Poloxamer 124 helps solubilize APIs in the formulation.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.


Poloxamers are block copolymers composed of ethylene oxide and propylene oxide.
With the suffixed number the mass percentages of the two components as well as the overall molecular mass are encoded.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.



USES and APPLICATIONS of POLOXAMER 124:
Poloxamer 124 is often used in skincare products such as creams, lotions, and serums, as well as in some makeup products and hair care products.
Poloxamer 124 is a versatile ingredient used in a wide range of cosmetics and personal care formulations due to its texture-enhancing and emulsifying properties.


Poloxamer 124 is often added to products like creams and serums to create a smooth and silky texture and to improve the overall appearance and feel of the product.
Additionally, Poloxamer 124 can help to solubilize and stabilize other ingredients in make up and hair care formulations.
Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.


Poloxamer 124 is also known for its non-irritating and non-sensitizing properties, making it suitable for use in products designed for sensitive skin.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.


Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.
Poloxamer 124 can be used as an excipient, such as Dispersant, emulsifier, solubilizer, lubricant, wetting agent, etc.
Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients.


Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations.
Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.


Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.
Poloxamer 124 is a High-HLB emulsiier that is commonly used in cleansing water formulas.
Poloxamer 124 is used to wash cosmetics.
Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.



ORIGIN OF POLOXAMER 124:
Poloxamer 124 is synthesized by the polymerization of propylene oxide and ethylene oxide, resulting in a block copolymer with a hydrophobic polypropylene oxide segment and a hydrophilic polyethylene oxide segment.
Poloxamer 124 appears as a white to off-white, waxy solid.



WHAT DOES POLOXAMER 124 DO IN A FORMULATION?
*Emulsifying
*Surfactant



FUNCTIONS OF POLOXAMER 124:
*Emulsifying :
Poloxamer 124 promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)
*Surfactant :
Poloxamer 124 reduces the surface tension of cosmetics and contributes to the even distribution of the product when it is used



BENEFITS OF POLOXAMER 124:
*Only monographed poloxamer that is liquid at room temperature
Ideal for liquid dosage forms
*Poloxamer 124 has melting point around 16°C and a hydrophiilic-lipophilic balance (HLB) value between 12-18
*Poloxamer 124 is used for liquid-filled softgel capsules as a dispersion medium for APIs, or as plasticizer for tablet formulations
*Poloxamer 124 is suitable for softgels, creams, foams, gels and emulsions




FUNCTIONS OF POLOXAMER 124 IN COSMETIC PRODUCTS:
*SURFACTANT - CLEANSING:
Surface-active agent to clean skin, hair and / or teeth

*SURFACTANT - EMULSIFYING:
Poloxamer 124 allows the formation of finely dispersed mixtures of oil and water (emulsions)



SAFETY PROFILE OF POLOXAMER 124:
Poloxamer 124 is a safe ingredient.
Poloxamer 124 is non irritating and non-comedogenic, so it does not cause any sensitivity issues or acne.
However, a patch test should be performed.
Additionally, since Poloxamer 124 is a synthetic ingredient, it is generally considered vegan and halal.



ALTERNATIVES OF POLOXAMER 124:
*CETEARETH20,
*POLYGLYCERYL3 DIISOSTEARATE,
*SORBITAN STEARATE



PHYSICAL and CHEMICAL PROPERTIES of POLOXAMER 124:
Physical state: powder
Color: No data available
Odor: No data available
Melting point/freezing point: 56,8 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature:
No data available
Decomposition
temperature:
No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available

Water solubility: No data available
Partition coefficient:
n-octanol/water:
No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Melting Point: 50-60°C
pH: 7.0
Solubility: Highly soluble in water
Viscosity: Low

CAS: 9003-11-6
Molecular Formula: C5H10O2
Molecular Weight (g/mol): 102.13
InChI Key: RVGRUAULSDPKGF-UHFFFAOYNA-N
IUPAC Name: 2-methyloxirane; oxirane
SMILES: C1CO1.CC1CO1
pH: 5.0 to 7.5
CAS Max %: 1
Water: 0.004
IUPAC Name: 2-methyloxirane;oxirane
Molecular Formula: C5H10O2
Canonical SMILES: CC1CO1.C1CO1
InChI Key: RVGRUAULSDPKGF-UHFFFAOYSA-N
Boiling Point: 32.9ºC at 760 mmHg
Melting Point: 60-50°C
Flash Point: 55.2°C
Density: 1.095 g/mL at 25°C

Appearance: White crystalline powder
Assay: 0.99
EC Number: 618-355-0
Exact Mass: 102.06800
Refractive Index: n20/D 1.466
Safety Description: 23-24/25-45-36/37/39-26
pH: 5.0 to 7.5
CAS Max %: 1
SMILES: C1CO1.CC1CO1
Molecular Weight (g/mol): 102.13
CAS:9003-11-6
Molecular Formula: C5H10O2
InChI Key: RVGRUAULSDPKGF-UHFFFAOYNA-N
IUPAC Name: 2-methyloxirane; oxirane
Grade: Reagent
Water: 0.004



FIRST AID MEASURES of POLOXAMER 124:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLOXAMER 124:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of POLOXAMER 124:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLOXAMER 124:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Respiratory protection:
Recommended Filter type: Filter type P1
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLOXAMER 124:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of POLOXAMER 124:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available


POLOXAMER 124
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.
Poloxamer 124 has also been used to control thickness (viscosity) of personal care products and dish soaps.
Poloxamer 124 is a polyoxyethylene, polyoxypropylene block polymer.

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

Poloxamer 124 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products.
This water-soluble polymer helps in emulsifying and stabilizing formulations, improving the texture, and enhancing the appearance of products.
Poloxamer 124 is often used in skincare products such as creams, lotions, and serums, as well as in some makeup products and hair care products.
Poloxamer 124 is known for its ability to create a smooth, silky texture and its non-irritating and non-sensitizing properties.
The chemical formula of Poloxamer 124 is C5H10O2.
Poloxamer 124 is synthesized by the polymerization of propylene oxide and ethylene oxide, resulting in a block copolymer with a hydrophobic polypropylene oxide segment and a hydrophilic polyethylene oxide segment.

Poloxamer 124 appears as a white to off-white, waxy solid.
Poloxamer 124 is a safe ingredient and has a very low toxicity profile.
Poloxamer 124 is non irritating and non-comedogenic, so it does not cause any sensitivity issues or acne.
However, a patch test should be performed.
Additionally, since Poloxamer 124 is a synthetic ingredient, it is generally considered vegan and halal.
Poloxamer 124 has an amphiphilic structure (both hydrophilic and lipophilic) and is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility.

Poloxamer 124 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 124 (9003-11-6)

Uses
Poloxamer 124 is a versatile ingredient used in a wide range of cosmetics and personal care formulations due to its texture-enhancing and emulsifying properties.
Poloxamer 124 is often added to products like creams and serums to create a smooth and silky texture and to improve the overall appearance and feel of the product.
Additionally, Poloxamer 124 can help to solubilize and stabilize other ingredients in make up and hair care formulations.
Poloxamer 124 is also known for its non-irritating and non-sensitizing properties, making it suitable for use in products designed for sensitive skin.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
Poloxamer 124 was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
Poloxamer 124 was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the Poloxamer 124 base plus the weight of added ethylene oxide.

Reports of adverse Effects
It was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used Poloxamer 124 as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 124 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000
POLOXAMER 124
SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6
POLOXAMER 184
SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6
POLOXAMER 188
SYNONYMS Oxirane, methyl-, polymer with oxirane (11;21);Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) CAS NO:9003-11-6
POLOXAMER 188
Poloxamer 188 is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
Poloxamer 188 was originally approved by the FDA in the 1960s as a therapeutic agent to reduce viscosity in the blood before transfusions, however it is no longer available in any approved products.
Due to Poloxamer 188's sufactant properties, P188 may also be found in over-the-counter (OTC) products such as toothpaste, laxatives and mouthwash, and used in various cosmetic, industrial and pharmaceutical applications.

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

There is an evidence of Poloxamer 188 increasing the structural stability and resealing of the plasma membrane via direct incorporation into the phospholipid bilayer.
The ability of Poloxamer 188 in attenuating membrane damage and cell injury has been demonstrated in a variety of in vivo and in vitro models.
The use of Poloxamer 188 as a potential treatment in different pathological conditions, such as chronic microvascular diseases and skeletal muscle deficiencies, is under investigation
Poloxamer 188 is a non-ionic surfactant used to control shear forces in suspension cultures.
Poloxamer 188 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass.
Poloxamer 188 is provided at a concentration of 10% and effective at a working concentration of 0.1%.
Poloxamer 188 BIO is supplied as white to slightly yellowish, coarse grained powder with a waxy consistency.
Poloxamer 188 is freely soluble in ethanol, freely soluble in water (opalescent solution), and is insoluble in diethyl ether, paraffin and fatty oils.

Poloxamer 188 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: <0.3 mm Hg ( 20 °C)
Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at <70 °Csoluble
Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 188 (9003-11-6)

Mechanism of action
Poloxamer 188 seals stable defects in cell membranes induced by skeletal muscle cell membranes rupture induced by ischemia-reperfusion injury, electroporation, irradiation, and heat damage.
The full mechanism of action of Poloxamer 188 in inducing cytoprotective effects is not clear; however, based on in vitro experiments and the structural similarity to plasmalemma, Poloxamer 188 may be directly incorporated into the phospholipid bilayer to attenuate the extent of tissue injury.
Poloxamer 188s high surface activity facilitates P188 to be inserted into lipid monolayers.
Poloxamer 188 is proposed to exert localized actions by only interacting with damaged and compromised bilayers where the local lipid packing density is reduced .
In addition to the direct interaction with the membrane, Poloxamer 188 was shown to inhibit MMP-9 protein levels and activity, as well as the NF-κB signal pathway, in the model of acute cerebral ischemia, which is associated with increased BBB permeability leading to cerebral edema and increased penetration.
Poloxamer 188 is a key factor in extracellular matrix.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
Poloxamer 188 was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
The final product was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the Poloxamer 188 base plus the weight of added ethylene oxide.

Reports of adverse Effects
Poloxamer 188 was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used Poloxamer 188 as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 188 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000
POLOXAMER 338
Poloxamer 338 is supplied as white or almost white, coarse grained powder with a waxy consistency.
Poloxamer 338 is freely soluble in water (opalescent solution) and ethanol; insoluble in diethyl ether, paraffin and fatty oils.
Poloxamer 338 primarily used as thickening agents and gel formers but also as wetting agents, as emulsifiers and solubilizers

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

Poloxamer 338 shows characteristic property of thermoreversible gelation upon cooling or heating
The high performance and safety is backed by comprehensive documentation.
Poloxamer 338 , also known as Pluronic, is a nonionic triblock copolymer composed of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) units.
Poloxamer 338 is a clear, viscous liquid or solid at room temperature, depending on its specific grade.
Poloxamers are designated with a number, such as Poloxamer 188 or Poloxamer 338, which indicates their molecular weight and composition.
Poloxamer 338 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant.
Poloxamer 338 consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature.
Poloxamer 338 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products such as contact lens cleaning solutions.

Poloxamer 338 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 338 (9003-11-6)

Uses
Poloxamer 338 has various applications in different industries, including:

Pharmaceutical and medical: Poloxamer 338 is widely used in pharmaceutical formulations and medical applications.
Poloxamer 338 is employed as a solubilizer, emulsifier, and stabilizer in liquid and semi-solid dosage forms such as creams, ointments, gels, and suppositories.
Poloxamer 338 can improve drug solubility, enhance bioavailability, and provide controlled drug release.
They are also utilized in eye drops, nasal sprays, and other topical formulations.

Personal care and cosmetics: Poloxamer 338 is utilized in the personal care and cosmetic industry.
Poloxamer 338 is commonly found in skincare products, cleansers, shampoos, and conditioners.
Poloxamers act as emulsifiers, surfactants, and texture modifiers, providing stability, foam enhancement, and improved sensory properties.

Industrial applications: Poloxamer 338 has industrial applications as well.
Poloxamer 338 is used as a lubricant and dispersant in various industrial processes, including plastics manufacturing, rubber production, and metalworking.
Poloxamer 338 can improve flow properties, reduce friction, and aid in dispersion of particles.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
Poloxamer 338 was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
Poloxamer 338 was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the Poloxamer 338 base plus the weight of added ethylene oxide.

Reports of adverse Effects
Poloxamer 338 was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used it as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 338 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000
POLOXAMER 407
POLOXAMER 101;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 101;Classification : Polymère de synthèse;Ses fonctions (INCI).Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile).Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Les poloxamères sont des copolymères non-ioniques à trois blocs, possédant typiquement un bloc central « hydrophobe » de polypropylène glycol (aussi appelé poly(oxyde de propylène)) et deux blocs externes hydrophiles de polyéthylène glycol (aussi appelé poly(oxyde d'éthylène)). Ces copolymères de type poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) ont pour formule générale H(OCH2CH2)x(OCH(CH3)CH2)y(OCH2CH2)xOH ou pour simplifier (EO)x(PO)y(EO)x. Le mot « poloxamère » a été créé par l'inventeur, Irving Schmolka, qui a déposé un brevet pour ces molécules en 1973.Du fait que la longueur des blocs du poloxamère peut être modifiée, il existe beaucoup de poloxamères différents, qui ont des propriétés légèrement différentes.Du fait de leur structure amphiphile, les poloxamères ont des propriétés surfactantes qui les rendent utiles dans le domaine industriel. Entre autres, ils peuvent être utilisés pour augmenter la solubilité dans l'eau de substances hydrophobes et huileuses, ou augmenter la miscibilité de deux substances de différente hydrophobicité.
POLOXAMER 407
Poloxamer 407 is an epoxide.
Poloxamer 407 is a lipoprotein secretion inhibitor.
Poloxamer 407 is a liquid surfactant polymer.

CAS: 9003-11-6
MF: (C3H6O.C2H4O)x
MW: 102.1317
EINECS: 618-355-0

Polyoxyethylene and polyoxypropylene block polymers are referred to as Poloxamer 407.
Poloxamer 407 are known by the trade name PluronicR followed by a letter and number, either L, F, or P, which refers to liquid, flake, or paste physical forms, respectively.
Poloxamer 407 is a polyoxyethylene polymer and a hydrophilic non-ionic surfactant.
Poloxamer 407 is made up of two blocks of hydrophilic polyethylene glycol on either side of a central hydrophobic polypropylene glycol block.
In cosmetic and personal products, Poloxamer 407 is used as an emulsifier and solubilizer.
Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers.

Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG).
The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units.
This particular compound is also known by the BASF trade name Poloxamer 407 or by the Croda trade name Synperonic PE/F 127.
BASF also offers a pharmaceutical grade, under trade name Kolliphor Poloxamer 407.
Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant.
Poloxamer 407 consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature.
Poloxamer 407 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products such as contact lens cleaning solutions.

Poloxamer 407 Chemical Properties
Melting point: 57-61 °C
Boiling point: >200 °C(lit.)
Density: 1.095 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: Refractive index: n20/D 1.466
Fp: >230 °F
Storage temp.: 2-8°C
Solubility H2O: at Form: solution
Color: APHA: ≤120, 50/50 in CH3OH
PH: 5.0-7.5 (100g/L in H2O)
PH Range: 5.0 - 7.5
Water Solubility: Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck: 13,7644
LogP: -1.293 (est)
EPA Substance Registry System: Poloxamer 407 (9003-11-6)

Poloxamer 407 generally occur as white, waxy, free-flowing prilled granules, or as cast solids.
They are practically odorless and tasteless.
At room temperature, Poloxamer 407 occurs as a colorless liquid.

Uses
Hard and soft surface cleaners, defoamers in coatings and water treatment.
Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.
Most of the common uses of Poloxamer 407 are related to its surfactant properties.
For example, Poloxamer 407 is widely used in cosmetics for dissolving oily ingredients in water.
Poloxamer 407 can also be found in multi-purpose contact lens cleaning solutions, where its purpose there is to help remove lipid films from the lens.
Poloxamer 407 can also be found in some mouthwashes.
There is research ongoing for using Poloxamer 407 for aligning severed blood vessels before gluing them surgically.
Poloxamer 407 can also be used for its thermogelling properties in aqueous media.
Poloxamer 407 is approved by the FDA for use as an excipient in a range of pharmaceutical dosage forms, and is listed in the Inactive Ingredient Database (IID).
Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties.
In a 30% solution by weight, poloxamer 407 forms a gel solid at room temperature but liquifies when chilled to 4 °C (39 °F).
This allows poloxamer 407 to serve as a removable support material, particularly for creating hollow channels or cavities inside hydrogels.
In this role, Poloxamer 407 is often referred to as a "sacrificial ink" or a "fugitive ink".

Pharmaceutical Applications
Poloxamer 407 is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.
The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic.
All of the Poloxamer 407 is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture.
Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;
Poloxamer 407 is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups.

Poloxamer 407 may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 407 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems.
More recently,Poloxamer 407 has found use in drug-delivery systems.
Therapeutically, Poloxamer 407 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; Poloxamer 407 is usually used in combination with a laxative such as danthron.
Poloxamer 407 may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.

Production Methods
Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol.
Ethylene oxide is then added to form the block copolymer.

Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide.
The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved.
Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380.
The product was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered.
The final product was a water insoluble Poloxamer 407polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.

(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide.
105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A).
The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.

Reports of adverse Effects
Poloxamer 407 was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.
A team from the Centre for Ageing and the ANZAC Research Institute in Sydney used Poloxamer 407 as a tool to demonstrate that cells in the liver behave like a sieve.
They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels.
However, the dose used is far higher than a person would be exposed to in toothpaste or mouthwash.

Synonyms
Poloxalene
9003-11-6
Poloxamer 188
Poloxamer 407
106392-12-5
Pluronic F-68
2-methyloxirane;oxirane
TERGITOL(TM)XH(NONIONIC)
Pluronic L
Pluronic L 122
Pluronic
691397-13-4
Poloxalkol
F-108
Poloxamer 331
Pluronic L 61
Pluronic L-81
Therabloat
Proxanol
Epan 485
Epan 710
Epan 785
Bloat Guard
Tergitol XH
Pluronic L44
Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxirane
Pluronic F 38
Pluronic F 68
Pluronic F 108
Pluronic F 127
Pluronic L 101
Pluronic L 121
Pluronic L-101
2-methyloxirane; oxirane
Hydrowet
Proksanol
Regulaid
Slovanik
Magcyl
Pluracol V
Pluronic F
Pluronic P
Monolan PB
Pluriol PE
Poloxalene L64
Poloxamer (NF)
Pluronic-68
Pluronic F86
BSP 5000
Poloxamer 108
Poloxamer 182LF
Rokopol 16P
Rokopol 30P
component of Casakol
Pluronic 10R8
Pluronic 31R2
Pluronic F 68LF
Pluronic F 87
Pluronic F 88
Pluronic F 98
Pluronic L 24
Pluronic L 31
Pluronic L 35
Pluronic L 44
Pluronic L 62
Pluronic L 64
Pluronic L 68
Pluronic L 92
Pluronic L122
Pluronic P 75
Pluronic P 85
Pluronic P-65
Pluronic P-75
Propylen M 12
Proxanol 158
Proxanol 228
Slovanik 630
Slovanik 660
Supronic B 75
RC 102
Wyandotte 7135
Emkalyx EP 64
Emkalyx L101
Genapol PF 10
Nixolen SL 19
Rokopol 30P9
Tergitol monionic XH
Vepoloxamer (USAN)
Pluronic C 121
Pluronic F 125
Pluronic P 104
Supronic E 400
Teric PE40
Teric PE60
Teric PE70
Velvetol OE 2NT1
Lutrol F (TN)
Newpol PE-88
Nissan Pronon 201
Emkalyx L 101
Plonon 201
Plonon 204
Pronon 102
Pronon 104
Pronon 201
Pronon 204
Pronon 208
Unilube 50MB26X
oxirane-propylene oxide
SK&F 18,667
Teric PE 61
Teric PE 62
Laprol 1502
Pluriol PE 6810
Voranol P 2001
Berol TVM 370
PEG-PPG-PEG
Unilube 50MB168X
Monolan 8000E80
Niax LG 56
Tergitol XH (nonionic)
Thanol E 4003
Eban 710
Epan 750
Epon 420
PPG Diol 3000EO
Synperonic PE 30/40
Pluronic F87-A7850
Niax 16-46
SCHEMBL11737
Pluronic l62(mw 2500)
Pluronic l64(mw 2900)
ethylene oxide propylene oxide
Propylene Oxide Ethylene Oxide
TsL 431
ADEKA PLURONIC F-108
Oligoether L-1502-2-30
CHEBI:32026
TVM 370
RVGRUAULSDPKGF-UHFFFAOYSA-N
LG 56
NSC63908
NSC-63908
WS 661
AKOS015912614
DB11451
SK & F 18,667
N 480
D01941
D10680
M 90/20
75H90000
Poloxamère 101 POLOXAMER 101
POLOXAMER 124;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 101;Classification : Polymère de synthèse;Ses fonctions (INCI).Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile).Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Les poloxamères sont des copolymères non-ioniques à trois blocs, possédant typiquement un bloc central « hydrophobe » de polypropylène glycol (aussi appelé poly(oxyde de propylène)) et deux blocs externes hydrophiles de polyéthylène glycol (aussi appelé poly(oxyde d'éthylène)). Ces copolymères de type poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) ont pour formule générale H(OCH2CH2)x(OCH(CH3)CH2)y(OCH2CH2)xOH ou pour simplifier (EO)x(PO)y(EO)x. Le mot « poloxamère » a été créé par l'inventeur, Irving Schmolka, qui a déposé un brevet pour ces molécules en 1973.Du fait que la longueur des blocs du poloxamère peut être modifiée, il existe beaucoup de poloxamères différents, qui ont des propriétés légèrement différentes.Du fait de leur structure amphiphile, les poloxamères ont des propriétés surfactantes qui les rendent utiles dans le domaine industriel. Entre autres, ils peuvent être utilisés pour augmenter la solubilité dans l'eau de substances hydrophobes et huileuses, ou augmenter la miscibilité de deux substances de différente hydrophobicité.
Poloxamère 124 ( POLOXAMER 124)
POLOXAMER 181;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 101;Classification : Polymère de synthèse;Ses fonctions (INCI).Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile).Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Les poloxamères sont des copolymères non-ioniques à trois blocs, possédant typiquement un bloc central « hydrophobe » de polypropylène glycol (aussi appelé poly(oxyde de propylène)) et deux blocs externes hydrophiles de polyéthylène glycol (aussi appelé poly(oxyde d'éthylène)). Ces copolymères de type poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) ont pour formule générale H(OCH2CH2)x(OCH(CH3)CH2)y(OCH2CH2)xOH ou pour simplifier (EO)x(PO)y(EO)x. Le mot « poloxamère » a été créé par l'inventeur, Irving Schmolka, qui a déposé un brevet pour ces molécules en 1973.Du fait que la longueur des blocs du poloxamère peut être modifiée, il existe beaucoup de poloxamères différents, qui ont des propriétés légèrement différentes.Du fait de leur structure amphiphile, les poloxamères ont des propriétés surfactantes qui les rendent utiles dans le domaine industriel. Entre autres, ils peuvent être utilisés pour augmenter la solubilité dans l'eau de substances hydrophobes et huileuses, ou augmenter la miscibilité de deux substances de différente hydrophobicité.
Poloxamère 181- POLOXAMER 181
POLOXAMER 184;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 184;Classification : Polymère de synthèse, Tensioactif non ionique;À SAVOIRLe Poloxamer 184, est un tensioactif non ionique composé de trois blocs polymères. lI est utilisé dans la formulation de nettoyants pour la peau, de produits de bain, de shampooings, de revitalisants, de bains de bouche, de démaquillants pour les yeux et d'autres produits pour la peau et les cheveux. On le retrouve très présent dans les eaux micellaires.Ses fonctions (INCI); Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile); Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Poloxamère 184- POLOXAMER 184
POLOXAMER 185. N° CAS : 9003-11-6. Nom INCI : POLOXAMER 185. Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Poloxamère 185-POLOXAMER 185
POLOXAMER 188;N° CAS : 9003-11-6;Origine(s) : Synthétique;Nom INCI : POLOXAMER 188;Classification : Polymère de synthèse;Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Poloxamère 188 POLOXAMER 188
POLOXAMER 231, N° CAS : 9003-11-6. Nom INCI : POLOXAMER 231. Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Poloxamère 231 POLOXAMER 231
POLOXAMER 338; N° CAS : 9003-11-6; Origine(s) : Synthétique;Nom INCI : POLOXAMER 338;Classification : Polymère de synthèse;Ses fonctions (INCI);Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile);Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Poloxamère 338 POLOXAMER 338
POLOXAMER 407, N° CAS : 9003-11-6, Origine(s) : Synthétique, Nom INCI : POLOXAMER 407, Classification : Polymère de synthèse. Le poloxamère 407, est un tensioactif non ionique appartenant à la classe des copolymères. Il est utilisé dans les produits cosmétiques pour dissoudre les ingrédients huileux dans l'eau. On le trouve assez souvent dans les bains de bouche. Ses fonctions (INCI): Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Poloxamère 407 POLOXAMER 407
Poly Aluminum Chloride; Polyaluminum chlorohydrate; PAC; Polyaluminum hydroxychloride; cas no: 1327-41-9
Poly Aluminum Chloride
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Polihexanide HCl; Lavasept; BG-IR; Arlagard E; Acticide SR 1296; polihexanidum CAS NO:32289-58-0
POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
DESCRIPTION:
Poly(1-vinylpyrrolidone-co-vinyl Acetate) can be used as a starting material to prepare a quasi-solid polymer electrolyte (QSPE) for dye-sensitized solar cells.

Poly(1-vinylpyrrolidone-co-vinyl Acetate) can be used to preparepolymer blend membranes for pervaporation separation of ethanol and2-ethylhexanol mixtures.

CAS number 25086-89-9

EINECS:200-001-8

MF: C10H15NO3

MW: 197.23



SYNONYMS OF POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone; aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone;


Poly(1-vinylpyrrolidone-co-vinyl Acetate) is a water-soluble polymer resin, which is a white powder, odorless and tasteless, easy to absorb moisture, soluble in water, ethanol and anhydrous alcohols, and has good adhesion, hygroscopicity and film-forming properties. and surface activity.

APPLICATIONS OF POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE):
Pharmaceutical field: VA64 is mainly used as a water-soluble adhesive and dry adhesive in granulation and direct compression technology, as a film-forming material in film coating, and as a channel former in taste-masking agents.
Poly(1-vinylpyrrolidone-co-vinyl Acetate) is applied to the sugar coating to prevent splintering, and the bottom coating is used to prevent moisture.

Industrial fields:
Poly(1-vinylpyrrolidone-co-vinyl Acetate) is used in industry as rewetting adhesives, adhesives for paper, adhesives for coatings, thickeners and protective colloids for various inks, emulsifiers commonly used in plant protection agents and protective colloid.


CHEMICAL AND PHYSICAL PROPERTIES OF POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
Product Name: Poly(1-vinylpyrrolidone-co-vinyl acetate)
form
powder
Quality Level
200
mol wt
average Mw ~50,000 (GPC vs. poly(ethylene oxide))
transition temp
Tg 64 °C
density
1.27 g/mL at 25 °C (lit.)
InChI
1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChI key
FYUWIEKAVLOHSE-UHFFFAOYSA-N
Appearance Colorless to Light orange to Yellow clear liquid
Total Nitrogen 4.2 to 4.8 %
Evaporation residue 46.0 to 54.0 %
Viscosity 800.0 to 3,000.0 mPa-s
Appearance White or slightly yellow hygroscopic powder or flakes
Solubility Soluble in water, 96% ethanol or chloroform
Identify A, B Meet the requirments
Solution Appearance Clear to cloudy
PH 3.0-7.0
Aldehyde ppm ≤500
Peroxide ppm ≤ 400
NVP ppm ≤ 10.0
Vinyl acetate ppm ≤ 5.0
Saponification value mg/g 230-270
Residue on ignition% ≤ 0.1
Vinyl acetate% 35.3-42.0
Hydrazine ppm ≤ 1.0
2-P% ≤ 0.5
Moisture% ≤ 5.0
Heavy metal ppm ≤ 20
Nitrogen content% 7.0-8.0
K value 26.0- 36.0
Appearance: White powder
Test: ≥99.00%
Density: 1.27
Boiling point: 217.6°C at 760 mmHg
Flash point: 254.7±28.5°C
Vapor pressure: 0.0±1.4 mmHg at 25°C
Refractive index: 1.517
Stability: Stable. Fuel, especially in powder form. Incompatible with strong oxidizing agents, strong reducing agents.
Vapor pressure: 0.132mmHg at 25°C
density 1.27 g/mL at 25 °C (lit.)
form powder
InChI key FYUWIEKAVLOHSE-UHFFFAOYSA-N
InChI 1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
mol wt average Mw ~50,000 (GPC vs. poly(ethylene oxide))
Quality Level 200
transition temp Tg 64 °C





SAFETY INFORMATION ABOUT POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



POLY(ETHYLENE GLYCOL) METHYL ETHER 1000
Poly(ethylene glycol) methyl ether 1000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2



Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 1000 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 1000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 1000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 1000 is Powder.
Poly(ethylene glycol) methyl ether 1000, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 1000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 1000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 1000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 1000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 1000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 1000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 1000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 1000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 1000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 1000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 1000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1000 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
Poly(ethylene glycol) methyl ether 1000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 1000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 1000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 1000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 1000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 1000 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 1000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 1000 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 1000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 1000 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 1000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 1000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1000 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 1000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 1000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 1000 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1000 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 1000 is available in powder form.


Poly(ethylene glycol) methyl ether 1000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 1000 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 1000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 1000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 1000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 1000 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 1000 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 1000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 1000.
Poly(ethylene glycol) methyl ether 1000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Poly(ethylene glycol) methyl ether 1000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 1000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 1000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 1000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 1000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
Poly(ethylene glycol) methyl ether 1000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
Physical state: Solid (pellets, flakes)
Color: Colorless
Odor: No data available
Melting point/freezing point: Melting point/range: 20 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 182 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity: Viscosity, kinematic: No data available; Viscosity, dynamic: No data available

Water solubility at 20 °C: Slightly soluble
Partition coefficient (n-octanol/water): No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available
Product Type: PEGylation Reagents
Group 1: OH

Form (20 deg.C): Solid
Storage Condition: Room temperature (Recommended in a cool and dark place, <15°C)
CAS RN: 9004-74-4
PubChem Substance ID: 253662346
MDL Number: MFCD00084416
Purity: n/a
Size: 100G
Unit: EA
Molecular Formula/Molecular Weight: n/a
CAS No: 9004-74-4
Physical State: Solid

Color: White
Melting Point: 40 °C
Condition to Avoid: n/a
Refractive Index: n/a
Specific Gravity: n/a
MDL No: MFCD00084416
SDBS: n/a
MINUM: n/a
PUBCSUB: 253662346
UNSPSC: 12352100
UN No: n/a
Hazard Class: n/a
DOT Name: n/a
Pkg Grp: n/a
TSCA: Yes



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 1000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


POLY(ETHYLENE GLYCOL) METHYL ETHER 1500
Poly(ethylene glycol) methyl ether 1500, with an average molecular weight of 1500, is widely used in various industries.
Poly(ethylene glycol) methyl ether 1500is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether



Poly(ethylene glycol) methyl ether 1500 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1500 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 1500 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 1500 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 1500 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 1500 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 1500 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 1500 is Powder.
Poly(ethylene glycol) methyl ether 1500, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 1500is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1500 has a range of potential uses.


Poly(ethylene glycol) methyl ether 1500, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 1500 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 1500 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 1500 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 1500 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 1500, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1500 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 1500 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 1500, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 1500, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 1500, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 1500 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
Poly(ethylene glycol) methyl ether 1500 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1500 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 1500 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 1500 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 1500 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 1500 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 1500 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 1500 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 1500 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 1500 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 1500 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 1500 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1500 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 1500 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 1500 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 1500 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 1500 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 1500 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 1500 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 1500 is available in powder form.


Poly(ethylene glycol) methyl ether 1500 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 1500 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 1500 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 1500 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 1500 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 1500 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 1500 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 1500 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 1500.
Poly(ethylene glycol) methyl ether 1500, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Poly(ethylene glycol) methyl ether 1500 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 1500 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 1500 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 1500's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 1500's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
Poly(ethylene glycol) methyl ether 1500 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
Physical state: Pellets, flakes
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 20°C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182°C - closed cup
Autoignition temperature: Not available
Decomposition temperature: Not available

pH: Not available
Viscosity: Kinematic viscosity: Not available; Dynamic viscosity: Not available
Water solubility at 20°C: Slightly soluble
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 1500:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

POLY(ETHYLENE GLYCOL) METHYL ETHER 2000
Poly(ethylene glycol) methyl ether 2000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 2000 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 2000 is used in pressure-sensitive and thermoplastic adhesives.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, Polyoxyethylene Monomethyl Ether, Poly(Ethylene Oxide) Methyl Ether, Poly(Ethylene Oxide) Monomethyl Ether,a-Methyl-?-hydroxypoly(oxy-1,2-ethanediyl), Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 2000, Methoxypolyethylene glycol, Methoxypolyethylene glycol 2000, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, mPEG thiol, methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em,



Poly(ethylene glycol) methyl ether 2000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 2000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 2000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 2000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 2000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 2000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 2000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 2000 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 2000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 2000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 2000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 2000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 2000 is Powder.
Poly(ethylene glycol) methyl ether 2000, with an average molecular weight of 2000, is widely used in various industries.


Poly(ethylene glycol) methyl ether 2000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 2000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 2000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 2000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 2000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 2000.
Poly(ethylene glycol) methyl ether 2000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 2000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 2000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 2000 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
Due to its low toxicity Poly(ethylene glycol) methyl ether 2000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 2000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 2000 is used for formulating screens or for optimization.
Poly(ethylene glycol) methyl ether 2000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 2000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.
Poly(ethylene glycol) methyl ether 2000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.


In addition, Poly(ethylene glycol) methyl ether 2000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.
Poly(ethylene glycol) methyl ether 2000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.


Moreover, Poly(ethylene glycol) methyl ether 2000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.
Poly(ethylene glycol) methyl ether 2000 is used as enteric release coatings.


Poly(ethylene glycol) methyl ether 2000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 2000 acts as a solvent for brake fluids.
Further, Poly(ethylene glycol) methyl ether 2000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.


In addition to this, Poly(ethylene glycol) methyl ether 2000 is used in surfactants, polyester and polyurethane based paints.
Poly(ethylene glycol) methyl ether 2000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 2000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) methyl ether 2000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 2000 is intended for laboratory use only, and it is not meant for human consumption.
Poly(ethylene glycol) methyl ether 2000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 2000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.


Poly(ethylene glycol) methyl ether 2000 is a versatile compound commonly used in various applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 2000 has a range of potential uses.


With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 2000 is available in powder form.
Poly(ethylene glycol) methyl ether 2000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 2000 is also used as a wetting agent and viscosity modifier.


Poly(ethylene glycol) methyl ether 2000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.
Crystallization grade Poly(ethylene glycol) methyl ether 2000 is used for formulating screens or for optimization


Poly(ethylene glycol) methyl ether 2000 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 2000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 2000.
Poly(ethylene glycol) methyl ether 2000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Poly(ethylene glycol) methyl ether 2000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 2000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 2000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 2000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 2000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
Poly(ethylene glycol) methyl ether 2000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
Physical state: Pellets, flakes
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 20°C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182°C - closed cup
Autoignition temperature: Not available
Decomposition temperature: Not available
pH: Not available
Viscosity:
Kinematic viscosity: Not available;
Dynamic viscosity: Not available

Water solubility at 20°C: Slightly soluble
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available
Formula: CH3O(CH2CH2O)nH
Color/Form: Neat
Melting point: 53 - 54°C
Formula: CH₃(OCH₂CH₂)nOH

MDL Number: MFCD00084416
CAS Number: 9004-74-4
Appearance (Form): Powder or crystals to flakes
Appearance (Colour): White to almost white to off white
Chemical State: Solid
Product Number: 81321
CAS Number: 9004-74-4
CAS: 9004-74-4
Molecular Formula: (C2H4O)nCH4O
Molecular Weight (g/mol): 76.10
MDL Number: MFCD00084416
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
PubChem CID: 8019
ChEBI: CHEBI:46790

IUPAC Name: 2-methoxyethan-1-ol
SMILES: COCCO
Melting Point: 53°C
Color: White
Physical Form: Crystalline Powder
Chemical Name or Material: Polyethylene Glycol Monomethyl Ether 2000
Molecular Formula/Molecular Weight: n/a
CAS No: 9004-74-4
Physical State: Solid
Color: White
Melting Point: 53°C
Condition to Avoid: n/a
Refractive Index: n/a
Specific Gravity: n/a
MDL No: MFCD00084416



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 2000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


POLY(ETHYLENE GLYCOL) METHYL ETHER 300
Poly(ethylene glycol) methyl ether 300 is a polyether compound with many applications in various industries, including pharmaceuticals, cosmetics, and food processing.
Poly(ethylene glycol) methyl ether 300s are polymers of ethylene oxide, and they are known for their water-soluble and biocompatible properties.
Poly(ethylene glycol) methyl ether 300 is a poly(ethylene glycol) compound having a methacrylate group at the alpha-terminus and a methyl group at the omega-terminus.

CAS Number: 26915-72-0
Molecular Formula: C13H24O6
Molecular Weight: 276.32606

Poly(ethylene glycol) methyl ether 300 is a hydrophilic polymer.
Poly(ethylene glycol) methyl ether 300 can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups.
When crosslinked into networks, Poly(ethylene glycol) methyl ether 300 can have high water content, forming "hydrogels".

Hydrogel formation can be initiated by either crosslinking Poly(ethylene glycol) methyl ether 300 by ionizing radiation or by covalent crosslinking of Poly(ethylene glycol) methyl ether 300 macromers with reactive chain ends.
Poly(ethylene glycol) methyl ether 300 is a suitable material for biological applications because it does not trigger an immune response.
Poly(ethylene glycol) methyl ether 300, often abbreviated as PEG 300, is a type of polyethylene glycol (PEG) derivative.

Poly(ethylene glycol) methyl ether 300 is a nonlinear analog of polyethylene glycol (PEG).
Poly(ethylene glycol) methyl ether 300 is a biocompatible homopolymer with a brush type structure that is mainly used to provide a PEG modified surface.
Poly(ethylene glycol) methyl ether 300 cross-linked polymeric materials (hydrogels) are suitable carriers for drug delivery and various other biomedical applications.

Poly(ethylene glycol) methyl ether 300 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers, to stabilize polymer emulsions, and in synthesis of comb polymers.
Poly(ethylene glycol) methyl ether 300 is a nonlinear analog of polyethylene glycol (PEG).
Poly(ethylene glycol) methyl ether 300 is a biocompatible homopolymer with a brush type structure that is mainly used to provide a PEG modified surface.

Poly(ethylene glycol) methyl ether 300 indicates the average molecular weight of the specific PEG at 400.PEG 3350 is a laxative.
Poly(ethylene glycol) methyl ether 300 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Poly(ethylene glycol) methyl ether 300 is a polyether compound with many applications from industrial manufacturing to medicine.

Poly(ethylene glycol) methyl ether 300 commonly referred to as PEG 300, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Due to its low toxicity, Poly(ethylene glycol) methyl ether 300 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 300 is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries.

Poly(ethylene glycol) methyl ether 300 serves as a kind of solubilizer, excipient, lubricant, and chemical reagent.
Poly(ethylene glycol) methyl ether 300 is a clear, colorless liquid that is made from sugar cane waste so it is naturally derived and renewable.
Poly(ethylene glycol) methyl ether 300 is completely soluble in water and has an average molecular weight of 288 - 311.

Poly(ethylene glycol) methyl ether 300 is another group of products with an incredibly long list of uses and applications from industrial uses to food and pharma, and everything in between.
Poly(ethylene glycol) methyl ether 300 is PEG-6-based plasticizer and mold release agent.
Poly(ethylene glycol) methyl ether 300 possesses lubricity and humectant properties.

Poly(ethylene glycol) methyl ether 300 maintains wet-tack strength.
Poly(ethylene glycol) methyl ether 300 is used in pressure sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 300 is a water-miscible polyether with an average molecular weight of 300 g/mol.

Poly(ethylene glycol) methyl ether 300 is a clear viscous liquid at room temperature with non-volatile, stable properties.
Poly(ethylene glycol) methyl ether 300is widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries.
Poly(ethylene glycol) methyl ether 300 with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.

These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Poly(ethylene glycol) methyl ether 300 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.

Poly(ethylene glycol) methyl ether 300 is soluble in water (mw 1,000) and many organic solvents.
Poly(ethylene glycol) methyl ether 300 molecules of approximately 2000 monomers.
Poly(ethylene glycol) methyl ether 300 is used in various applications from industrial chemistry to biological chemistry.

Recent research has shown Poly(ethylene glycol) methyl ether 300 maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.
They serve as solubilizers, excipients, lubricants, and chemical reagents.
Low molecular weight Poly(ethylene glycol) methyl ether 300s are observed to exhibit antibacterial properties as well.

Poly(ethylene glycol) methyl ether 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.
Poly(ethylene glycol) methyl ether 300 is a neutral and biocompatible hydrophilic polymer.
Poly(ethylene glycol) methyl ether 300 is usually used to modify therapeutic proteins and peptides to increase their solubility.

Poly(ethylene glycol) methyl ether 300 is used as a moisturizer, solubiliser in antiperspirant and deodorants, shampoos and liquid soap, hair styling products, bar soaps and oral care products as a stabilizer and wetting agent for drilling.
Poly(ethylene glycol) methyl ether 300 is a polymer which is hydrolyzed by ethylene oxide.
Poly(ethylene glycol) methyl ether 300 has no toxicity and irritation.

Poly(ethylene glycol) methyl ether 300 is widely used in various pharmaceutical preparations.
The toxicity of low molecular weight Poly(ethylene glycol) methyl ether 300 is relatively large.
In general, the toxicity of diols is very low.

Topical application of Poly(ethylene glycol) methyl ether 300, especially mucosal drug, can cause irritant pain.
In topical lotion, Poly(ethylene glycol) methyl ether 300 can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Poly(ethylene glycol) methyl ether 300 is a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.

Poly(ethylene glycol) methyl ether 300 cross-linked polymeric materials (hydrogels) are suitable carriers for drug delivery and various other biomedical applications.
Poly(ethylene glycol) methyl ether 300 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers, to stabilize polymer emulsions, and in synthesis of comb polymers.
Poly(ethylene glycol) methyl ether 300 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.

Poly(ethylene glycol) methyl ether 300 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
Poly(ethylene glycol) methyl ether 300 is a highly pure polymer of ethylene glycol with one methyl ether group.

Poly(ethylene glycol) methyl ether 300 has been used as multipurpose molecular tool for various chemical applications.
Poly(ethylene glycol) methyl ether 300 has also been used in a wide array of other biochemical and immunological applications.
Poly(ethylene glycol) methyl ether 300, a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.

Poly(ethylene glycol) methyl ether 300 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
Polyethylene glycol 300 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of Polyethylene glycol 300 is commonly expressed as H−(O−CH2−CH2)n−OH.

Poly(ethylene glycol) methyl ether 300 is one of the most commonly used chemical polyethers in manufacturing, medicine and many other applications.
Poly(ethylene glycol) methyl ether 300 is available in multiple forms for various uses.

The most common way of differentiating between Polyethylene glycol 300 is by molecular weight.
Poly(ethylene glycol) methyl ether 300 is used as a base for skin creams and other personal care products, as well as a solvent and viscosity modifier in soaps and detergents.

Melting point: 33-38 °C
Boiling point: 54 °C
Density: 1.1 g/mL at 25 °C
refractive index: n20/D 1.496
Flash point: >230 °F
storage temp.: -20°C
form: Granular Solid
color: White to off-white
Water Solubility: Soluble in water.

Poly(ethylene glycol) methyl ether 300 specifically refers to a PEG with an average molecular weight around 300 g/mol.
The "methyl ether" part of the name indicates that it has methyl groups attached to the ether oxygen atoms.
The presence of these groups can influence the properties and applications of the polymer.

Poly(ethylene glycol) methyl ether 300 and other PEG derivatives are commonly used in pharmaceuticals as excipients, solubilizing agents, and drug delivery carriers.
They are also utilized in various formulations to improve the solubility and bioavailability of certain drugs.
Additionally, Poly(ethylene glycol) methyl ether 300s are used in the preparation of cosmetics, as they are generally well-tolerated by the skin and have moisturizing properties.

Poly(ethylene glycol) methyl ether 300 is also used to process rubber, plastics and textiles, as an additive in lubricants and grease, and as a humectant, dye carrier and binder in paints and inks.
Poly(ethylene glycol) methyl ether 300 is colorless, almost odorless and tasteless liquid at room temperature.
Poly(ethylene glycol) methyl ether 300 is manufactured by alkali-catalysed polymerization of ethylene oxide with subsequent neutralization of the catalyst.

Poly(ethylene glycol) methyl ether 300 is sometimes used as a plasticizer and lubricant in various industries.
In plastics and rubber manufacturing, Poly(ethylene glycol) methyl ether 300 can enhance flexibility and reduce brittleness.
In pharmaceuticals, Poly(ethylene glycol) methyl ether 300 may serve as a lubricant in tablet formulations.

Poly(ethylene glycol) methyl ether 300s, including PEG 300, are generally stable under various environmental conditions.
This stability contributes to their suitability for use in a wide range of applications.
The physical properties of Poly(ethylene glycol) methyl ether 300s, such as viscosity and solubility, can be temperature-dependent.

Some formulations may take advantage of these temperature-dependent properties, especially in applications such as controlled drug release systems.
Poly(ethylene glycol) methyl ether 300 can be blended with other polymers to achieve specific properties in the resulting material.
Blending Poly(ethylene glycol) methyl ether 300 with other polymers can be a strategy to tailor the physical and chemical characteristics of the final product.

Compatibility with Other Ingredients: When formulating pharmaceuticals, cosmetics, or other products, compatibility with other ingredients is crucial.
Poly(ethylene glycol) methyl ether 300 is often chosen for its compatibility with a wide range of compounds, facilitating the creation of stable formulations.
Poly(ethylene glycol) methyl ether 300, there are other PEG derivatives with different molecular weights, such as PEG 400, PEG 600, etc.

The choice of a specific Poly(ethylene glycol) methyl ether 300 derivative depends on the requirements of a particular application.
Poly(ethylene glycol) methyl ether 300 is a subject of ongoing research and development to explore new applications and improve existing formulations.
Scientists and researchers continually investigate the properties of Poly(ethylene glycol) methyl ether 300s to expand their utility in various fields.

Poly(ethylene glycol) methyl ether 300 in pharmaceuticals and other products is subject to regulatory standards and guidelines.
Manufacturers must adhere to these regulations to ensure the safety and efficacy of the final product.
Poly(ethylene glycol) methyl ether 300 is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointment and suppository base, and tablet and capsule lubricant.

Poly(ethylene glycol) methyl ether 300 has low toxicity with systemic absorption less than 0.5%.
Poly(ethylene glycol) methyl ether 300 occurs when PEGs are attached to various protein medications, allowing for greater solubility for certain drugs.

Poly(ethylene glycol) methyl ether 300 is highly soluble in water and many organic solvents.
This solubility makes Poly(ethylene glycol) methyl ether 300 a versatile compound for use in various formulations.
Poly(ethylene glycol) methyl ether 300, are known to be hygroscopic, meaning they can absorb and retain water from their surroundings.

This property can be beneficial in formulations where moisture content is a consideration.
The viscosity of Poly(ethylene glycol) methyl ether 300 is relatively low, which makes it useful for applications where a low-viscosity liquid is desirable.
This property is advantageous in the pharmaceutical industry for formulating liquid dosage forms.

Poly(ethylene glycol) methyl ether 300s are generally considered biocompatible and are widely used in pharmaceuticals and medical applications.
Their use in drug formulations is often attributed to their ability to enhance the solubility of poorly soluble drugs and improve drug delivery.
Poly(ethylene glycol) methyl ether 300 is often employed in drug delivery systems, such as in the preparation of micelles, nanoparticles, and liposomes.

These drug delivery systems can improve the stability and bioavailability of certain drugs.
Poly(ethylene glycol) methyl ether 300 can be found in various personal care products, including creams, lotions, and ointments, where it functions as a humectant, helping to retain moisture in the skin.

The structure of Poly(ethylene glycol) methyl ether 300 consists of repeating ethylene glycol units, with methyl ether groups attached to the oxygen atoms.
Poly(ethylene glycol) methyl ether 300 structure contributes to its physical and chemical properties.

Uses:
Poly(ethylene glycol) methyl ether 300, is used as Emulsion polymers, cosmetics, construction, emulsifiers.
Poly(ethylene glycol) methyl ether 300 is used in a number of toothpastes as a dispersant.
In this application, Poly(ethylene glycol) methyl ether 300 binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.

Poly(ethylene glycol) methyl ether 300 is also under investigation for use in body armor, and in tattoos to monitor diabetes.
Polymer segments derived from Poly(ethylene glycol) methyl ether 300 polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
In low-molecular-weight formulations (e.g. PEG 400), Poly(ethylene glycol) methyl ether 300 is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.

Poly(ethylene glycol) methyl ether 300 is also used as an anti-foaming agent in food and drinks.
Poly(ethylene glycol) methyl ether 300 is often used as a solubilizing agent to enhance the solubility of poorly soluble drugs.
This is particularly important in the formulation of oral and injectable medications.

Poly(ethylene glycol) methyl ether 300 is employed as an excipient in pharmaceutical formulations, contributing to the stability and bioavailability of drugs.
Poly(ethylene glycol) methyl ether 300 is used in the development of drug delivery systems such as micelles, liposomes, and nanoparticles, aiding in controlled drug release.
Poly(ethylene glycol) methyl ether 300 functions as an emollient in cosmetic products, helping to soften and moisturize the skin.

Poly(ethylene glycol) methyl ether 300 is hygroscopic properties make it useful as a humectant, retaining moisture in cosmetic formulations.
Poly(ethylene glycol) methyl ether 300 may be used as a carrier for active ingredients in cosmetic products.
Poly(ethylene glycol) methyl ether 300 acts as a plasticizer, improving the flexibility and durability of plastics and rubber products.

Poly(ethylene glycol) methyl ether 300 can be used as an emulsifying agent in food products, assisting in the dispersion of oil and water phases.
Poly(ethylene glycol) methyl ether 300 may contribute to the stability of certain food formulations.
Poly(ethylene glycol) methyl ether 300 is used as a lubricant in various processes, including tablet manufacturing in the pharmaceutical industry.

Poly(ethylene glycol) methyl ether 300 serves as an intermediate in the synthesis of other chemicals and polymers.
Poly(ethylene glycol) methyl ether 300 is utilized as a reagent in laboratory experiments and research studies.
Poly(ethylene glycol) methyl ether 300 can be blended with other polymers to achieve specific properties in the resulting material.

Poly(ethylene glycol) methyl ether 300 may be used as a softening agent in textile processing.
Poly(ethylene glycol) methyl ether 300 can be used as a plasticizing agent in the formulation of adhesives and sealants.
Poly(ethylene glycol) methyl ether 300 may be used in the preparation of a polyelectrolytic solution for the development of lithium ion batteries.

Poly(ethylene glycol) methyl ether 300 can be photopolymerized to form a zwitterionic monomer which can be coated on steel surfaces for bio-fouling based applications.
An example study was done using PEG-diacrylate hydrogels to recreate vascular environments with the encapsulation of endothelial cells and macrophages.
This model furthered vascular disease modeling and isolated macrophage phenotype's effect on blood vessels.

Poly(ethylene glycol) methyl ether 300 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Although polyethylene glycol is considered biologically inert, it can form non-covalent complexes with monovalent cations such as Na+, K+, Rb+, and Cs+, affecting equilibrium constants of biochemical reactions.
Poly(ethylene glycol) methyl ether 300 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.

X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
Poly(ethylene glycol) methyl ether 300 is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.
In microbiology, Poly(ethylene glycol) methyl ether 300 precipitation is used to concentrate viruses.

Poly(ethylene glycol) methyl ether 300 is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.
Poly(ethylene glycol) methyl ether 300-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.
The size of the Poly(ethylene glycol) methyl ether 300 polymer has been shown to be important, with larger polymers achieving the best immune protection.

Poly(ethylene glycol) methyl ether 300 is a component of stable nucleic acid lipid particles (SNALPs) used to package siRNA for use in vivo.
In blood banking, Poly(ethylene glycol) methyl ether 300 is used as a potentiator to enhance detection of antigens and antibodies.
When working with phenol in a laboratory situation, Poly(ethylene glycol) methyl ether 300 can be used on phenol skin burns to deactivate any residual phenol.

In biophysics, polyethylene glycols are the molecules of choice for the functioning ion channels diameter studies, because in aqueous solutions they have a spherical shape and can block ion channel conductance.
Poly(ethylene glycol) methyl ether 300 can be used in the development of molecular brushes as a substrate material for stimuli-responsive surfaces in biomedical applications.
Poly(ethylene glycol) methyl ether 300 may be used in the surface modification of poly(ether sulfone) based ultrafiltration (UF) membrane as a foul-resistant material.

Poly(ethylene glycol) methyl ether 300 is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
Poly(ethylene glycol) methyl ether 300 is the basis of a number of laxatives (as MiraLax, RestoraLAX, etc.).
Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy or for children with constipation.

Macrogol (with brand names such as Laxido, GoLytely and Miralax) is the generic name for Poly(ethylene glycol) methyl ether 300 used as a laxative.
The name may be followed by a number which represents the average molecular weight (e.g. macrogol 3350, macrogol 4000 or macrogol 6000).
The possibility that Poly(ethylene glycol) methyl ether 300 could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.

An example of Poly(ethylene glycol) methyl ether 300 hydrogels (see Biological uses section) in a therapeutic has been theorized by Ma et al.
They propose using the hydrogel to address periodontitis (gum disease) by encapsulating stem cells in the gel that promote healing in the gums.
The gel with encapsulated stem cells was to be injected into the site of disease and crosslinked to create the microenvironment required for the stem cells to function.

Poly(ethylene glycol) methyl ether 300 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Poly(ethylene glycol) methyl ether 300 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
Poly(ethylene glycol) methyl ether 300 is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.

Poly(ethylene glycol) methyl ether 300 segments derived from PEG polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
In microbiology, Poly(ethylene glycol) methyl ether 300 precipitation is used to concentrate viruses.
Poly(ethylene glycol) methyl ether 300 is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.

Gene therapy vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.
The size of the Poly(ethylene glycol) methyl ether 300 polymer has been shown to be important, with larger polymers achieving the best immune protection.
Poly(ethylene glycol) methyl ether 300 is a component of stable nucleic acid lipid particles used to package siRNA for use in vivo.

In blood banking, Poly(ethylene glycol) methyl ether 300 is used as a potentiator to enhance detection of antigens and antibodies.
Poly(ethylene glycol) methyl ether 300of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity.
Poly(ethylene glycol) methyl ether 300 lipid is used as an excipient in both the Moderna and Pfizer–BioNTech vaccines for SARS-CoV-2.

Both RNA vaccines consist of messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids.
Proprietary lipid technology is used for each.
In both vaccines, the bubbles are coated with a stabilizing molecule of Poly(ethylene glycol) methyl ether 300.

As of December 2020 there is some concern that Poly(ethylene glycol) methyl ether 300 could trigger allergic reaction, and in fact allergic reactions are the driver for both the United Kingdom and Canadian regulators to issue an advisory, noting that: two "individuals in the U.K.
As of 18 December, the US CDC stated that in their jurisdiction six cases of "severe allergic reaction" had been recorded from more than 250,000 vaccinations, and of those six only one person had a "history of vaccination reactions".

Poly(ethylene glycol) methyl ether 300 has a low toxicity and is used in a variety of products.
Poly(ethylene glycol) methyl ether 300 is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments.
Since Poly(ethylene glycol) methyl ether 300 is a flexible, water-soluble polymer, it can be used to create very high osmotic pressures (on the order of tens of atmospheres).

Poly(ethylene glycol) methyl ether 300 also is unlikely to have specific interactions with biological chemicals.
These properties make Poly(ethylene glycol) methyl ether 300 one of the most useful molecules for applying osmotic pressure in biochemistry and biomembranes experiments, in particular when using the osmotic stress technique.
Poly(ethylene glycol) methyl ether 300 is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.

Poly(ethylene glycol) methyl ether 300 replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.
In addition, Poly(ethylene glycol) methyl ether 300 is used when working with green wood as a stabilizer, and to prevent shrinkage.
Poly(ethylene glycol) methyl ether 300 has been used to preserve the painted colors.

These painted artifacts were created during.
Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry.
Poly(ethylene glycol) methyl ether 300 is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.

Poly(ethylene glycol) methyl ether 300 is frequently used to preserve waterlogged wood and other organic artifacts that have been salvaged from underwater archaeological contexts, as was the case with the warship Vasa in Stockholm, and similar cases.
Poly(ethylene glycol) methyl ether 300 replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.
In addition, Poly(ethylene glycol) methyl ether 300 is used when working with green wood as a stabilizer, and to prevent shrinkage.

Poly(ethylene glycol) methyl ether 300 has been used to preserve the painted colors on Terracotta Warriors unearthed at a UNESCO World Heritage site in China.
These painted artifacts were created during the Qin Shi Huang (first emperor of China) era.
Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry Xi'an air.

The paint would subsequently flake off in about four minutes.
The German Bavarian State Conservation Office developed a Poly(ethylene glycol) methyl ether 300 preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay soldiers.
Poly(ethylene glycol) methyl ether 300 is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.

Poly(ethylene glycol) methyl ether 300 derivatives, such as narrow range ethoxylates, are used as surfactants.
Poly(ethylene glycol) methyl ether 300 has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
Poly(ethylene glycol) methyl ether 300 is a component of the propellent used in UGM-133M Trident II Missiles, in service with the United States Navy.

Poly(ethylene glycol) methyl ether 300 has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.
Poly(ethylene glycol) methyl ether 300 is also used as a polymer host for solid polymer electrolytes.
Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving Poly(ethylene glycol) methyl ether 300, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.

Poly(ethylene glycol) methyl ether 300 is injected into industrial processes to reduce foaming in separation equipment.
Poly(ethylene glycol) methyl ether 300 is used as a binder in the preparation of technical ceramics.
Poly(ethylene glycol) methyl ether 300 was used as an additive to silver halide photographic emulsions.

Poly(ethylene glycol) methyl ether 300 is used in a number of toothpastes[5] as a dispersant.
In this application, Poly(ethylene glycol) methyl ether 300 binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
Poly(ethylene glycol) methyl ether 300 is also under investigation for use in body armor, and in tattoos to monitor diabetes.

In low-molecular-weight formulations (e.g. PEG 400), Polyethylene glycol 300 is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.
Poly(ethylene glycol) methyl ether 300 is also used as an anti-foaming agent in food and drinks.

Safety Profile:
Poly(ethylene glycol) methyl ether 300 may cause irritation to the skin and eyes, especially in concentrated or pure form.
Prolonged or repeated contact with the skin should be avoided.
Inhalation of vapor or mist may cause respiratory irritation.

Adequate ventilation should be maintained in areas where Poly(ethylene glycol) methyl ether 300 is used, and exposure to airborne particles should be minimized.
Poly(ethylene glycol) methyl ether 300 is generally not expected to cause significant harm, but it is not intended for consumption.
Accidental ingestion may lead to gastrointestinal discomfort.

Synonyms:
PEG-6 dimethyl ether
Genosorb 300
Carpol CLE 1000
Dimethoxy polyethylene glycol
Genosorb 175
Glycols, polyethylene, dimethyl ether
Glyme-23
Nissan Unisafe MM 1000
Nissan Unisafe MM 400
O5E08Z8AEA
PEG-6 DME
PEG-DME 2000
POLY(ETHYLENE GLYCOL) DIMETHYL ETHER (300 MW)
POLYGLYCOL DME 300
POLYGLYME-6
Polyoxyethylene dimethyl ether
Sanfine DM 1000
Sanfine DM 200
Sanfine DM 400
Selexol
U-Nox DM 1000
U-Nox DM 200
UNII-7GSD980LF9
UNII-9I2Z48JZJ5
UNII-O5E08Z8AEA
UNII-OMW34MPM4E
UNII-W83S1I1CJE
Varonic DM 55
alpha,omega-Methoxypoly(ethylene oxide)
alpha-Methyl-omega-methoxypoly(oxy-1,2-ethanediyl)

POLY(ETHYLENE GLYCOL) METHYL ETHER 3000
Poly(ethylene glycol) methyl ether 3000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 3000 maintains wet-tack strength and possesses lubricity and humectant properties.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2



Poly(ethylene glycol) methyl ether 3000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 3000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 3000 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 3000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 3000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 3000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 3000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 3000 is Powder.
Poly(ethylene glycol) methyl ether 3000, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 3000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 3000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 3000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 3000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 3000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 3000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 3000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 3000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 3000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 3000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 3000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 3000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 3000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 3000 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
Poly(ethylene glycol) methyl ether 3000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 3000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 3000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 3000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 3000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 3000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 3000 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 3000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 3000 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 3000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 3000 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 3000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 3000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 3000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 3000 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 3000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 3000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 3000 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 3000 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 3000 is available in powder form.


Poly(ethylene glycol) methyl ether 3000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 3000 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 3000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 3000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 3000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 3000 is used for formulating screens or for optimization.
Crystallization grade Poly(ethylene glycol) methyl ether 3000 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 3000 is a hydrophilic polymer that is used to control the flexibility of a composite.


Poly(ethylene glycol) methyl ether 3000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.
Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 3000.
Poly(ethylene glycol) methyl ether 3000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Poly(ethylene glycol) methyl ether 3000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 3000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 3000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 3000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 3000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
Poly(ethylene glycol) methyl ether 3000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
Physical state: pellets, flakes
Color: colorless
Odor: No data available
Melting point/range: 20 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 182 °C (closed cup)
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity:
Kinematic viscosity: No data available
Dynamic viscosity: No data available
Water solubility at 20 °C: Slightly soluble
Partition coefficient (n-octanol/water): No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 3000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


POLY(ETHYLENE GLYCOL) METHYL ETHER 350
Physical Form of Poly(ethylene glycol) methyl ether 350 is Powder.
Poly(ethylene glycol) methyl ether 350, with an average molecular weight of 350, is widely used in various industries.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 350, Methoxypolyethylene glycol, Methoxypolyethylene glycol 350, Methoxypolyethylene glycol, Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 350, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em, Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, MARLIPAL 1/7, METHOXY PEG-7, METHOXY PEG-7 [INCI], METHOXYPOLYETHYLENE GLYCOL 350, METHOXYPOLYOXYETHYLENE GLYCOL 350, MPEG 350, MPEG-7, PEG-7 METHYL ETHER, PEG-7 METHYL ETHER [II], PEG-7 METHYL ETHER [INCI], POLYETHYLENE GLYCOL (7) METHYL ETHER, POLYETHYLENE GLYCOL 350 METHYL ETHER, POLYXOYETHYLENE (7) METHYL ETHER, 9004-74-4, MARLIPAL 1/7, METHOXY PEG-7, METHOXY PEG-7 [INCI], METHOXYPOLYETHYLENE GLYCOL 350, METHOXYPOLYOXYETHYLENE GLYCOL 350, MPEG 350, MPEG-7, PEG-7 METHYL ETHER, PEG-7 METHYL ETHER [II], PEG-7 METHYL ETHER [INCI], POLYETHYLENE GLYCOL (7) METHYL ETHER, POLYETHYLENE GLYCOL 350 METHYL ETHER, POLYXOYETHYLENE (7) METHYL ETHER,



Poly(ethylene glycol) methyl ether 350 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 350 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 350 maintains wet-tack strength and possesses lubricity and humectant properties.


Poly(ethylene glycol) methyl ether 350 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 350 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 350 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 350 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 350 is Powder.
Poly(ethylene glycol) methyl ether 350, with an average molecular weight of 350, is widely used in various industries.


Poly(ethylene glycol) methyl ether 350is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 350 has a range of potential uses.


Poly(ethylene glycol) methyl ether 350, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 350 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 350 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 350 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 350 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 350, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 350 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 350 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 350, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 350, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 350, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 350 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
Poly(ethylene glycol) methyl ether 350 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 350 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 350 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 350 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 350 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 350 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 350 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 350 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 350 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 350 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 350 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 350 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 350 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 350 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 350 is intended for laboratory use only, and it is not meant for human consumption.


Poly(ethylene glycol) methyl ether 350 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 350 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 350 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 350 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 350 is available in powder form.


Poly(ethylene glycol) methyl ether 350 is used as a solvent, excipient, surfactant and dispersing agent.
Crystallization grade Poly(ethylene glycol) methyl ether 350 is used for formulating screens or for optimization


Poly(ethylene glycol) methyl ether 350 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 350 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 350 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.


Poly(ethylene glycol) methyl ether 350 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
Crystallization grade Poly(ethylene glycol) methyl ether 350 is used for formulating screens or for optimization.


Poly(ethylene glycol) methyl ether 350 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 350 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 350.
Poly(ethylene glycol) methyl ether 350, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Poly(ethylene glycol) methyl ether 350 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 350 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 350 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 350's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 350's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
Poly(ethylene glycol) methyl ether 350 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
Category: Detergents, Anionic detergents
Appearance: Liquid, Colourless
pH: 4.5-7.5
Hydroxyl Value: 152-168
Physical State: Liquid
Solubility: Soluble in water (partly)
Storage: Store at room temperature
Melting Point: 52-56°C
Density: 1.09 g/mL
Refractive Index: n20D 1.46
CAS Number: 9004-74-4
Molecular Formula: (C2H4O)nCH4O
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N

SMILES: COCCO
MDL Number: MFCD00084416
Molecular Weight: 325 to 375 D
Residual Water: 0.5% max
Physical state: Paste
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 64 - 69 °C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182 °C
Autoignition temperature: Not available

Decomposition temperature: Not available
pH: Not available
Viscosity: Kinematic viscosity: Not available, Dynamic viscosity: Not available
Water solubility: Not available
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: Not available
Other safety information: Not available
Formula: CH₃(OCH₂CH₂)nOH

Density: 1.09
Flash Point: >110 °C (230 °F)
Storage Temperature: Ambient
MDL Number: MFCD00084416
CAS Number: 9004-74-4
CAS Registration Number: 9004-74-4
Unique Ingredient Identifier: ENK4Y6S66X
Molecular Formula: CH3(OCH2CH2)nOH
CAS Number: 9004-74-4
Molecular Weight: 76.09
HS Code: 39072090
pH: 4.0 to 8.0 (1% aqueous solution)
Physical Form: Liquid
Linear Formula: CH3(OCH2CH)nOH

Density: 1.09 g/mL
Quantity: 500 g
Hydroxyl Value: 152 to 168 mg KOH/g
Infrared Spectrum: Authentic
Refractive Index: 1.4560 to 1.4580 (20°C, 589 nm)
Water: 0.15% max. (Karl Fischer method)
Chemical Name or Material: Poly(ethylene glycol methylether), Average M.W. 350
CAS Number: 9004-74-4
Category: Polymer/Macromolecule
Molecular Weight: 350
Boiling Point: >200°C (decomposes)

Melting Point: -8°C
Flash Point: 360°F
Density: 1.091 (20°C)
Alpha Sort: Polyethylene glycol monomethyl ether
Viscosity: 4.1 cSt (99°C)
CAS Registry Number: 9004-74-4
Classification: POLYETHERS
Formula: CH3O + (C2H4O)n + H
Instrument Name: Bio-Rad FTS 175C with Raman accessory
Molecular Weight (Average): 350



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 350:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


POLY(ETHYLENE GLYCOL) METHYL ETHER 400
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 400 has a range of potential uses.
Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 400, Methoxypolyethylene glycol, Methoxypolyethylene glycol 400 methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em, Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2



Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 400 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 400 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 400 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 400 is used in pressure-sensitive and thermoplastic adhesives.


Poly(ethylene glycol) methyl ether 400 is a polymer similar in structure and nomenclature to polyethylene glycols.
Physical Form of Poly(ethylene glycol) methyl ether 400 is Powder.
Poly(ethylene glycol) methyl ether 400, with an average molecular weight of 750, is widely used in various industries.


Poly(ethylene glycol) methyl ether 400is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 400 has a range of potential uses.


Poly(ethylene glycol) methyl ether 400, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 400 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 400 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 400 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 400 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 400, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 400 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 400 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 400, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 400, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 400, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 400 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
Poly(ethylene glycol) methyl ether 400 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) methyl ether 400 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 400 is intended for laboratory use only, and it is not meant for human consumption.
Poly(ethylene glycol) methyl ether 400 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 400 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.
Poly(ethylene glycol) methyl ether 400 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.


In addition, Poly(ethylene glycol) methyl ether 400 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.
Poly(ethylene glycol) methyl ether 400 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.


Moreover, Poly(ethylene glycol) methyl ether 400 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.
Poly(ethylene glycol) methyl ether 400 is used as enteric release coatings.


Poly(ethylene glycol) methyl ether 400 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 400 acts as a solvent for brake fluids.
Further, Poly(ethylene glycol) methyl ether 400 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.


In addition to this, Poly(ethylene glycol) methyl ether 400 is used in surfactants, polyester and polyurethane based paints.
Poly(ethylene glycol) methyl ether 400 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 400 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 400 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 400 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 400 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 400 is available in powder form.


Poly(ethylene glycol) methyl ether 400 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 400 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 400 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Due to its low toxicity Poly(ethylene glycol) methyl ether 400 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 400 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 400 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 400 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 400 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 400.
Poly(ethylene glycol) methyl ether 400, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400 :
*Poly(ethylene glycol) methyl ether 400 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 400 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 400 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 400's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 400's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
Poly(ethylene glycol) methyl ether 400 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
Categories: Detergents, Anionic detergents
Appearance: Colorless liquid
pH: 4.5-7.5
Refractive Index: 1.46
Hydroxyl Value: 130-150
Physical State (20°C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN: 9004-74-4
PubChem Substance ID: 253662344
MDL Number: MFCD00084416
Chemical Name or Material: Polyethylene Glycol Monomethyl Ether 400
Color: Yellow

Synonym: methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether,
methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol,
3-oxa-1-butanol, egme, monomethyl glycol, dowanol em
SMILES: COCCO
Molecular Weight (g/mol): 76.10
ChEBI: CHEBI:46790
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
IUPAC Name: 2-methoxyethan-1-ol
PubChem CID: 8019
Average molecular weight: 380 to 420
Melting Point: n/a
Specific Gravity: 1.09
Physical state: Pellets, flakes

Color: Colorless
Odor: No data available
Melting point/freezing point: Melting point/range: 20°C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 182°C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity: Viscosity, kinematic: No data available; Viscosity, dynamic: No data available

Water solubility at 20°C: Slightly soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 400:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

POLY(ETHYLENE GLYCOL) METHYL ETHER 5000
Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 5000 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 5000 maintains wet-tack strength and possesses lubricity and humectant properties.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, Methoxypolyethylene glycols, METHOXY POLYETHYLENE GLYCOL 750, Poly(ethylene glycol methyl ether), Poly(ethylene glycol) methyl ether, ETHYLENE GLYCOL 750 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 550 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 350 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 1900 MONOMETHYL ETHER POLYMER, ETHYLENE GLYCOL 5000 MONOMETHYL ETHER POLYMER, 2-ethanediyl), alpha.-methyl.-omega.-hydroxy-Poly(oxy-1, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG, mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether



Poly(ethylene glycol) methyl ether 5000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 5000 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 5000 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 5000, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 5000, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.
Poly(ethylene glycol) methyl ether 5000, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.


Poly(ethylene glycol) methyl ether 5000 offers ample flexibility with availability in bulk and pre-packs.
Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 5000 is PEG-6 methyl ether-based plasticizer.


Poly(ethylene glycol) methyl ether 5000 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 5000 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 5000 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 5000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.
Physical Form of Poly(ethylene glycol) methyl ether 5000 is Powder.


Poly(ethylene glycol) methyl ether 5000, with an average molecular weight of 750, is widely used in various industries.
Poly(ethylene glycol) methyl ether 5000is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 5000 has a range of potential uses.


Poly(ethylene glycol) methyl ether 5000, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 5000 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 5000 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 5000 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 5000 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
Crystallization grade Poly(ethylene glycol) methyl ether 5000 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 5000 is a hydrophilic polymer that is used to control the flexibility of a composite.
Poly(ethylene glycol) methyl ether 5000 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.


Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 5000.
Poly(ethylene glycol) methyl ether 5000, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.


Poly(ethylene glycol) methyl ether 5000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 5000 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 5000 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 5000 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 5000 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 5000 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 5000 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 5000 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 5000 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 5000 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.


In addition to this, Poly(ethylene glycol) methyl ether 5000 is used in surfactants, polyester and polyurethane based paints.
Poly(ethylene glycol) methyl ether 5000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 5000 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) methyl ether 5000 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.


Poly(ethylene glycol) methyl ether 5000 is intended for laboratory use only, and it is not meant for human consumption.
Poly(ethylene glycol) methyl ether 5000 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 5000 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.


Poly(ethylene glycol) methyl ether 5000 is a versatile compound commonly used in various applications.
Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 5000 has a range of potential uses.


With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 5000 is available in powder form.
Poly(ethylene glycol) methyl ether 5000 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 5000 is also used as a wetting agent and viscosity modifier.


Poly(ethylene glycol) methyl ether 5000 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.
Due to its low toxicity Poly(ethylene glycol) methyl ether 5000 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.


Poly(ethylene glycol) methyl ether 5000 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
Crystallization grade Poly(ethylene glycol) methyl ether 5000 is used for formulating screens or for optimization.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Poly(ethylene glycol) methyl ether 5000 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 5000 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 5000 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 5000's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 5000's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
Poly(ethylene glycol) methyl ether 5000 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
Physical state: Pellets, flakes
Color: Colorless
Odor: Not available
Melting point/freezing point: Melting point/range: 20 °C
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: 182 °C - closed cup
Autoignition temperature: Not available
Decomposition temperature: Not available
pH: Not available
Viscosity:
Kinematic: Not available,
Dynamic: Not available

Water solubility at 20 °C: Slightly soluble
Partition coefficient: n-octanol/water: Not available
Vapor pressure: Not available
Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available
Poly(ethylene glycol) methyl ether 5000
Catalog number: B2010415
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 g
Molecular Weight or Concentration: average Mn 5,000
Supplied as: Flakes/crystals
Appearance: White

Ω-end hydroxyl
α-end methoxy
Form: Powder or crystals, flakes
InChI key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
InChI: 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
Mol wt: Average Mn 5,000
MP: 60-64 °C
Vapor density: >1 (vs air)
Vapor pressure: 0.05 mmHg ( 20 °C)
CAS Number: 9004-74-4
CAS: 9004-74-4
EINECS: 618-394-3
InChI: InChI=1/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
Molecular Formula: C5H12O3
Molar Mass: 120.14698

Density: 1.094g/mL at 25°C
Melting Point: 60-64°C
Boiling Point: >200°C/760mmHg
Flash Point: 268 °C
Water Solubility: Slightly miscible with water.
Solubility: H2O: 50mg/mL at 25°C, clear, colorless
Vapor Pressure: 0.05 mm Hg ( 20 °C)
Vapor Density: >1 (vs air)
Appearance: White crystal
Specific Gravity: 1.094
Color: White to pale yellow
Maximum wavelength(λmax): ['λ: 260 nm Amax: 0.06', 'λ: 280 nm Amax: 0.03']
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Storage Condition: -20°C
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
Sensitive: Easily absorbing moisture
Refractive Index: n20/D 1.459
MDL: MFCD00084416



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 5000:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available


POLY(ETHYLENE GLYCOL) METHYL ETHER 750
Poly(ethylene glycol) methyl ether 750 is used in pressure-sensitive and thermoplastic adhesives.
Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH



SYNONYMS:
mPEG , Methoxy poly(ethylene glycol) , Methoxypolyethylene glycols , PEG MME , Poly(ethylene glycol) methyl ether, methyl cellosolve, ethanol, 2-methoxy, ethylene glycol monomethyl ether, methyl oxitol, 2-methoxy-1-ethanol, methoxyethanol, 3-oxa-1-butanol, egme, monomethyl glycol, dowanol em, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, mPEG thiol, Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-, Glycols,polyethylene,monomethyl ether, Polyethylene glycol monomethyl ether, Carbowax 350, Polyethylene glycol methyl ether, Ethylene oxide-methanol adduct, α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl), Methyl polyglycol, Carbowax 750, Methoxypoly(ethylene glycol), Carbowax 550, Carbowax 2000, Carbowax 5000, Monomethoxypolyethylene glycol, MPEG, MPEG 5000, Monomethoxypolyoxyethylene, Nissan Uniox M 2000, Hymol PM, MPG 025, MPG 081, Nissan Uniox M 400, O-Methoxypolyethylene glycol, Breox MPEG 550, GN 8384, CP 2000 (polyoxyalkylene), CP 2000, Monomethoxy poly(ethylene oxide), Nissan Uniox M 550, Poly(ethylene oxide) monomethyl ether, Toho Me-PEG 400, Toho Me-PEG 1000, Uniox M 400, Nissan Uniol 1000, Nissan Uniol 550, MPEG 500, Nissan Uniox M 1000, Uniox M 1000, Uniox M 2000, Carbowax 750ME, MPG 130, Uniox M 550, Polyglycol M 750, Sanfine MM 2000, MPEG 350, MPEG 2000, MPEG 10000, Nissan Uniox M 600, Carbowax MPEG 5000, Pluriol A 500E, Pluriol A 350E, Pluriol A 275E, Nissan Uniox M 4000, MPEG 950, Sunbright MEH 20T, MPG, Carbowax MPEG 450, Pluriol A 2000E, MPG 140, Pluriol A 2000, Methoxy PEG 400, Me-PEG 400, Conion MP 220, Polyoxyethylene monomethyl ether, Polyglycol M 5000S, Polyglycol M 2000S, M 550, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol, Pluriol 350E, M 750, MPEG 750, Pluriol 500, Polyglycol M 500, Uniox M 4000, Sunbright MEH 50H, Pluriol A 750I, Marlipal 1/12, 5702-16-9, 12623-96-0, 41396-14-9, 54386-07-1, 57244-93-6, 64543-87-9, 69592-91-2, 72664-19-8, 77102-87-5, 86002-19-9, 91826-72-1, 95507-78-1, 95507-80-5, 102868-77-9, 104841-59-0, 114740-40-8, 126966-17-4, 134919-42-9, 138753-86-3, 142172-77-8, 146162-92-7, 154701-70-9, 154885-26-4, 158360-78-2, 162582-19-6, 163294-10-8, 163733-28-6, 165338-17-0, 166441-82-3, 178613-33-7, 185250-24-2, 187523-66-6, 189209-93-6, 193008-24-1, 195970-98-0, 207799-14-2, 212969-32-9, 216693-45-7, 226212-72-2, 237739-71-8, 241466-57-9, 396134-26-2, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG, Methoxypolyethylene glycol, Poly(ethylene glycol) methyl ether, mono-Methyl polyethylene glycol 500,



Physical Form of Poly(ethylene glycol) methyl ether 750 is Powder.
Poly(ethylene glycol) methyl ether 750, with an average molecular weight of 750, is widely used in various industries.
Poly(ethylene glycol) methyl ether 750is a reliable raw material that can be utilized in the production of drugs, chemicals, and many other applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 750 has a range of potential uses.
Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.


Poly(ethylene glycol) methyl ether 750 is PEG-6 methyl ether-based plasticizer.
Poly(ethylene glycol) methyl ether 750 maintains wet-tack strength and possesses lubricity and humectant properties.
Poly(ethylene glycol) methyl ether 750 is used in pressure-sensitive and thermoplastic adhesives.


Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 750 is a polymer similar in structure and nomenclature to polyethylene glycols.
Poly(ethylene glycol) methyl ether 750 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


Poly(ethylene glycol) methyl ether 750, commonly referred to as PEG 2000 Monomethylether, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Poly(ethylene glycol) methyl ether 750 is a hydrophilic macromonomer used to introduce hydrophilic sites into polymers and stabilize polymer emulsions.


It is a Poly(ethylene glycol) methyl ether 750 with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) methyl ether 750 chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) methyl ether 750 can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.


Poly(ethylene glycol) methyl ether 750, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 750 offers ample flexibility with availability in bulk and pre-packs.


Poly(ethylene glycol) methyl ether 750 is a high quality research product used as highly pure Poly(ethylene glycol) methyl ether (mPEG) with an average MW of 5000.
Poly(ethylene glycol) methyl ether 750, also referred to as Methoxy poly(ethylene glycol) or Polyethylene glycol monomethyl ether, is an exceptional and versatile compound designed to meet the diverse requirements of both research and industrial settings.


Poly(ethylene glycol) methyl ether 750, with its unique chemical formula and distinguished properties, pushes the boundaries of versatility, proving to be an indispensable tool for numerous professional applications.


Poly(ethylene glycol) methyl ether 750, known as Methoxy poly(ethylene glycol), is a powerful asset in research and industrial settings due to its excellent solubility and stability profile, and a wide range of applications.
Poly(ethylene glycol) methyl ether 750 offers ample flexibility with availability in bulk and pre-packs.



USES and APPLICATIONS of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
Poly(ethylene glycol) methyl ether 750 is a versatile compound with a range of potential applications.
Poly(ethylene glycol) methyl ether 750 is commonly known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, or mPEG.
Poly(ethylene glycol) methyl ether 750 is a versatile compound commonly used in various applications.


Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG, Poly(ethylene glycol) methyl ether 750 has a range of potential uses.
With the CAS Number 9004-74-4 and the linear formula CH3(OCH2CH2)nOH, Poly(ethylene glycol) methyl ether 750 is available in powder form.


Poly(ethylene glycol) methyl ether 750 is used as a solvent, excipient, surfactant and dispersing agent.
Poly(ethylene glycol) methyl ether 750 is also used as a wetting agent and viscosity modifier.
Poly(ethylene glycol) methyl ether 750 finds application in the cosmetic and pharmaceutical industry due its low toxicity, lubricating property and solubility.


Poly(ethylene glycol) methyl ether 750 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 750 is widely used in biochemical research where its properties as a hydrophilic polymer are beneficial for modifying protein solubility and stability.


Poly(ethylene glycol) methyl ether 750 plays a significant role in the field of proteomics, assisting researchers in solubilizing proteins for structural analysis and functional studies.
In addition, Poly(ethylene glycol) methyl ether 750 is employed in nanoparticle research, where it is used to improve the dispersion and stability of nanoparticles in various solvents, facilitating studies on their potential applications.


Poly(ethylene glycol) methyl ether 750 is also pivotal in surface science, where it is applied to modify surfaces to resist protein and cell adhesion, crucial for investigating biomaterial interactions.
Moreover, Poly(ethylene glycol) methyl ether 750 is utilized in the synthesis of chemical delivery systems, where it enhances the bioavailability and controlled release of loaded agents, aiding in the exploration of new delivery methodologies.


Poly(ethylene glycol) methyl ether 750 is used as enteric release coatings.
Poly(ethylene glycol) methyl ether 750 is also used for a series of polycarboxylate water reducing agent.
Poly(ethylene glycol) methyl ether 750 acts as a solvent for brake fluids.


Further, Poly(ethylene glycol) methyl ether 750 is used in the building materials industry and raw material for cement water reducing agent and strengthening agent.
In addition to this, Poly(ethylene glycol) methyl ether 750 is used in surfactants, polyester and polyurethane based paints.


Poly(ethylene glycol) methyl ether 750 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 750 is used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.


Poly(ethylene glycol) methyl ether 750 is used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) methyl ether 750 is intended for laboratory use only, and it is not meant for human consumption.


Due to its low toxicity Poly(ethylene glycol) methyl ether 750 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Poly(ethylene glycol) methyl ether 750 is used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.


Crystallization grade Poly(ethylene glycol) methyl ether 750 is used for formulating screens or for optimization.
Crystallization grade Poly(ethylene glycol) methyl ether 750 is used for formulating screens or for optimization
Poly(ethylene glycol) methyl ether 750 is a hydrophilic polymer that is used to control the flexibility of a composite.


Poly(ethylene glycol) methyl ether 750 can be used for a variety of applications such as drug delivery, tissue engineering, and other biological uses.
Unleash the power of the multi-functional Poly(ethylene glycol) methyl ether 750.
Poly(ethylene glycol) methyl ether 750, formulated to meet the varied demands of research and industry, enhances efficiency and assurances reproducible results, contributing to superior performance and success in all your endeavors.



FEATURES AND BENEFITS OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750 :
*Poly(ethylene glycol) methyl ether 750 is biodegradable, water-soluble polymer.
*Applications of Poly(ethylene glycol) methyl ether 750 include drug encapsulation and drug delivery.



KEY FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750 :
*Versatile compound with a range of potential uses
*Commonly used in various applications
*Also known as Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, and mPEG
*CAS Number: 9004-74-4
*Linear formula: CH3(OCH2CH2)nOH
*Available in powder form



INHERENT ADVANTAGES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
*Superlative solubility in a variety of solvents including water, ethanol, acetone, and chloroform.
*Imperturbable stability under multiple conditions, enhancing the consistency of experimental results.
*User-friendly packaging - available in both bulk and prepack sizes, catering to diverse scale applications.
*The exceptional solubility and stability offered by Poly(ethylene glycol) methyl ether 750 make it invaluable for use across various sectors.
*Poly(ethylene glycol) methyl ether 750's superior stability facilitates reliable and reproducible results, which are fundamental in research and industrial operations.
*Poly(ethylene glycol) methyl ether 750's availability in different packaging formats allows custom scalability according to individual requirements.



SAFETY AND HANDLING OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
Poly(ethylene glycol) methyl ether 750 necessitates adherence to safety protocols.
Always follow the instructions provided in the Material Safety Data Sheet (MSDS) for a comprehensive understanding of safe handling, storage, and disposal procedures.



FEATURES OF POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
*Sterile filtered solution
*Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (


PHYSICAL and CHEMICAL PROPERTIES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
CAS: 9004-74-4
Molecular Formula: (C2H4O)nCH4O
Molecular Weight (g/mol): 76.10
MDL Number: MFCD00084416
InChI Key: XNWFRZJHXBZDAG-UHFFFAOYSA-N
PubChem CID: 8019
ChEBI: CHEBI:46790
SMILES: COCCO
Specification Sheet:
Residual water: 3% max
Molecular Weight: 715 to 785
pH: 4.5 to 7.5 (5% aq. soln., 25°C)
Form: Fused mass/clear liquid as a melt

Melting Point: 28–32°C
Density: 1.10
Flash Point: >110°C (230°F)
Storage Temperature: Ambient
Physical Properties:
Color: Colorless to Yellow
Physical Form: Low Melting Solid
Melting Point: 28°C to 32°C
Density: 1.10 g/mL
Solubility: Slightly miscible with water
Chemical Name or Material: Polyethylene glycol monomethylether, 750
Additional Information:

Ω-end: hydroxyl
α-end: methoxy
Molecular Weight: average Mn 750
Refractive Index: n20/D 1.459
Transition Temperature: Tm 30°C
Vapor Density: >1 (vs air)
Vapor Pressure: 0.05 mmHg (20°C)
Viscosity: 10.5 cSt (210°F) (lit.)
Physical State: Pellets, flakes
Flash Point: 182°C - closed cup
Oxidizing Properties: None
Other Safety Information: No data available



FIRST AID MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Choose body protection in relation to its type.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
*Storage stability:
Recommended storage temperature:
-20 °C



STABILITY and REACTIVITY of POLY(ETHYLENE GLYCOL) METHYL ETHER 750:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

POLY(ETHYLENE GLYCOL) MONOMETHYL ETHER
Poly(ethylene glycol) monomethyl ether is a PEG linker containing a hydroxyl group.
The Poly(ethylene glycol) monomethyl ether enables further derivatization or replacement with other reactive functional groups.
The Poly(ethylene glycol) monomethyl ether spacer increases solubility in aqueous media.

CAS Number: 9004-74-4
Molecular Formula: C5H12O3
Molecular Weight: 120.14698
EINECS Number: 618-394-3

Poly(ethylene glycol) monomethyl ether is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether.
Etherification of the Poly(ethylene glycol) monomethyl ether chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Poly(ethylene glycol) monomethyl ether can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

Poly(ethylene glycol) monomethyl ether, also known as PEG Monomethyl Ether, is a type of polyethylene glycol (PEG) derivative.
Poly(ethylene glycol) monomethyl ethers are polymers that are widely used in various industries for their solubility, stability, and ability to modify the physical properties of substances.
Poly(ethylene glycol) monomethyl ether specifically refers to PEG molecules with a single methyl (CH3) group attached to one end of the polymer chain.

Poly(ethylene glycol) monomethyl ether can be used as a pore-forming agent to prepare polysulfone membranes with enhanced hydrophilicity.
Poly(ethylene glycol) methyl ether-grafted polyamidoamine (PAMAM) dendrimers can be used as drug carrier systems for anticancer drugs.
Poly(ethylene glycol) monomethyl ether is the main material to produce polycarboxylate high water reducing agent.

Poly(ethylene glycol) monomethyl ether effective cement Good water solubility, wettability, lubricity, physiologically inert properties, irritability.
Poly(ethylene glycol) monomethyl etherwith medium properties is widely used in the cosmetic and pharmaceutical industries.
Poly(ethylene glycol) monomethyl ether are a series of methyl substituted poly(ethylene) glycols that have been used with some success in the crystallization of a number of hydrophobic proteins.

Poly(ethylene glycol) monomethyl ether cellosolve is an organic compound with the formula C3H8O2 used.
Poly(ethylene glycol) monomethyl ether is a clear, colorless liquid with an ether-like odor.
Poly(ethylene glycol) monomethyl ether is in a class of solvents known as glycol ethers, noted for their ability to dissolve a variety of substances.

Different types of chemical compounds have miscibility with water and other solvents.
Poly(ethylene glycol) monomethyl ether can be formed by nucleophilic attack of methanol on protonated ethylene oxide followed by proton.
Poly(ethylene glycol) monomethyl ether is used as a solvent for many different purposes such as varnishes, paints and resins.

Poly(ethylene glycol) monomethyl ether is also used as an additive in aircraft defrosting solutions.
Poly(ethylene glycol) monomethyl ether is widely used for the synthesis of Vaska complex and related compounds.
Poly(ethylene glycol) monomethyl ether is toxic to bone marrow and testicles.

Those exposed to high levels are at risk for granulocytopenia, macrocytic anemia, oligospermia and azoospermia.
Poly(ethylene glycol) monomethyl ether is converted to methoxyacetic acid (methoxyacetic acid) by alcohol dehydrogenase.
Poly(ethylene glycol) monomethyl ether ethanol and acetate have a protective effect.

Poly(ethylene glycol) monomethyl ether can enter the Krebs cycle where Polyethylene Glycol is present.
Poly(ethylene glycol) monomethyl ether is a group of solvents based on alkyl ethylene glycol or propylene glycol ethers commonly used in paints and cleaners.
Typically, low molecular weight ethers have a higher boiling point with favorable solvent properties.

Typically Poly(ethylene glycol) monomethyl ether is found as: pharmaceutical, sunscreens, cosmetics, inks, paints and water-based paints, Polyethylene Glycol Monomethyl Ether is used in degreasers, cleaners, aerosol paints and adhesives.
Poly(ethylene glycol) monomethyl ether comes in various molecular weights, which refers to the size of the polymer chain.
Different molecular weights of Poly(ethylene glycol) monomethyl ether can have slightly different properties and applications.

The specific molecular weight chosen can impact factors like solubility, viscosity, and compatibility with other substances.
In addition to the pharmaceutical uses mentioned earlier, Poly(ethylene glycol) monomethyl ether and other PEG derivatives are employed in medical and healthcare settings.
Certain Poly(ethylene glycol) monomethyl ether derivatives are used in medical imaging techniques like magnetic resonance imaging (MRI) and computed tomography (CT) scans to enhance contrast and improve visualization of certain tissues.

Poly(ethylene glycol) monomethyl ether, the process of attaching PEG molecules to drugs or drug carriers, can alter the pharmacokinetics of drugs, extending their circulation time in the body and potentially reducing immunogenicity.
Poly(ethylene glycol) monomethyl ether can have various derivatives, such as those modified with different functional groups or chain lengths.
These derivatives can exhibit specific properties suited to particular applications.

Poly(ethylene glycol) monomethyl ether is used to improve the solubility of poorly water-soluble drugs, enhancing their bioavailability and effectiveness.
Poly(ethylene glycol) monomethyl ether's incorporated into drug delivery systems to modify the release profile of drugs, enabling controlled and sustained drug delivery.
Poly(ethylene glycol) monomethyl ether Monomethyl Ether provides moisturization and smoothness to the skin, making it a popular ingredient in lotions, creams, and moisturizers.

Poly(ethylene glycol) monomethyl ether's used as an emulsifier in cosmetic formulations, helping blend water and oil-based ingredients.
Poly(ethylene glycol) monomethyl ether is sometimes employed to functionalize nanoparticles and improve their biocompatibility and stability.
Poly(ethylene glycol) monomethyl ether can also help nanoparticles evade the immune system, making them more suitable for medical applications like targeted drug delivery.

Poly(ethylene glycol) monomethyl ether, play a role in the development of biomaterials for tissue engineering, wound healing, and regenerative medicine.
Their water solubility, non-reactive nature, and ability to modify surface properties make them valuable in these contexts.
Research is ongoing to develop biodegradable and environmentally friendly alternatives to certain Poly(ethylene glycol) monomethyl ether derivatives, addressing concerns about persistence and accumulation in the environment.

Regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) oversee the safety and approval of Poly(ethylene glycol) monomethyl ether derivatives used in pharmaceuticals and other applications.
These agencies assess factors like toxicity, stability, and potential allergic reactions.

Melting point: 60-64 °C
Boiling point: >200°C/760mmHg
Density: 1.094 g/mL at 25 °C
vapor density: >1 (vs air)
vapor pressure: 0.05 mm Hg ( 20 °C)
refractive index: n20/D 1.459
Flash point: 268 °C
storage temp.: -20°C
solubility: H2O: 50 mg/mL at 25 °C, clear, colorless
form: semisolid
Specific Gravity: 1.094
color: White to pale yellow
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility: Slightly miscible with water.
λmax: λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.03
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
LogP: -0.800 (est)

Poly(ethylene glycol) monomethyl ether can be used as intermediates undergoing further chemical reactions.
The basic physicochemical properties of Poly(ethylene glycol) monomethyl ether were determined over a wide temperature range.
The impact of the introduction of brake fluids on key quality indices was studied on Poly(ethylene glycol) monomethyl ether borates.

Advances in electronics and life sciences have sparked interest in "lab-on-a-chip" systems that use complementary metals.
Poly(ethylene glycol) monomethyl ether polymer brushes are used as biointerface coatings to enhance their relevance in biosensing.
Using the surface-initiated "grafting" strategy, Poly(ethylene glycol) monomethyl ether films were reliably grown on each surface.

These Poly(ethylene glycol) monomethyl ether films were also studied to determine the potential impact on the environment.
Electronic devices providing information about the relative permeability and fault area for Poly(ethylene glycol) monomethyl ether are available in both dry and aqueous form.
Poly(ethylene glycol) monomethyl ether was shown that the addition of Polyethylene Glycol Monomethyl Ether coatings significantly reduced nonspecific levels.

Poly(ethylene glycol) monomethyl ether is a type of polyethylene glycol derivative.
The basic structure of Poly(ethylene glycol) monomethyl ether consists of repeating units of ethylene glycol.
In the case of Poly(ethylene glycol) monomethyl ether, a single methyl (CH3) group is attached to one end of the polyethylene glycol chain.

This modification gives PEG Monomethyl Ether its specific properties.
Poly(ethylene glycol) monomethyl ether possesses several important properties that make it useful in various applications.
Poly(ethylene glycol) monomethyl ether is highly water-soluble.

This property makes it useful for formulating aqueous solutions and products.
Poly(ethylene glycol) monomethyl ether is non-ionic, meaning it doesn't carry a net electrical charge.
This property contributes to its compatibility with a wide range of substances.

Poly(ethylene glycol) monomethyl ether has emollient properties, making it useful for softening and moisturizing the skin.
This characteristic is beneficial in cosmetic and personal care products.
Poly(ethylene glycol) monomethyl ether is chemically stable and does not readily undergo reactions with other substances.

Poly(ethylene glycol) monomethyl ether is available in different variants based on its molecular weight, which can range from low to high.
The choice of variant depends on the specific application and the desired properties, such as viscosity, solubility, and compatibility with other ingredients.
The presence of the polyethylene glycol chain in Poly(ethylene glycol) monomethyl ether imparts hydrophilic (water-attracting) properties to the compound.

This hydrophilic nature can influence its interactions with water, other molecules, and surfaces.
The addition of the methyl group at one end provides a degree of hydrophobic (water-repelling) character.
This balance between hydrophilicity and hydrophobicity allows Poly(ethylene glycol) monomethyl ether to play diverse roles in various formulations.

Poly(ethylene glycol) monomethyl ether is used in combination with other ingredients to achieve specific performance characteristics.
Blending it with other surfactants, emulsifiers, or polymers can help optimize the final product's stability, viscosity, texture, and other properties.
Poly(ethylene glycol) monomethyl ether, are used in drug formulation to overcome challenges such as poor solubility, instability, and rapid clearance from the body.

By modifying drug molecules with Poly(ethylene glycol) monomethyl ether, their therapeutic effects can be prolonged, reducing the frequency of administration and improving patient compliance.
Poly(ethylene glycol) monomethyl ether is a key strategy to enhance the properties of nanoparticles and improve their circulation time in the bloodstream.
Poly(ethylene glycol) monomethyl ether nanoparticles can improve drug delivery to target tissues and reduce non-specific interactions with blood components, thus enhancing their efficacy and safety.

One of the reasons PEG and its derivatives like Poly(ethylene glycol) monomethyl ether is widely used is their biocompatibility and inertness.
They generally do not provoke strong immune responses or induce toxicity.
This makes them suitable for various medical and pharmaceutical applications.

Poly(ethylene glycol) monomethyl ether itself is relatively stable and non-reactive, the environmental impact of PEG derivatives can vary.
Some Poly(ethylene glycol) monomethyl ether derivatives are considered biodegradable, while others may persist in the environment for longer periods.
Researchers and manufacturers are exploring eco-friendly alternatives and considering factors such as biodegradation and eventual breakdown into non-harmful components.

Research in the field of polymers and materials science, including Poly(ethylene glycol) monomethyl ether, is ongoing.
Scientists are continually exploring new ways to modify these compounds to suit specific applications, improve their biodegradability, and enhance their performance in various industries.

Uses
Poly(ethylene glycol) monomethyl ether has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Poly(ethylene glycol) monomethyl ether has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Poly(ethylene glycol) monomethyl ether of with an average molecular mass of 350.

Poly(ethylene glycol) monomethyl ether is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.
Poly(ethylene glycol) monomethyl ether's mild surfactant properties are employed in shampoos, body washes, and cleansing products.
Poly(ethylene glycol) monomethyl ether can be found in hair care products for its conditioning and anti-static effects.

Poly(ethylene glycol) monomethyl ether is used as a solvent or diluent in adhesive formulations.
Poly(ethylene glycol) monomethyl ether is added to coatings to improve flow, leveling, and texture.
Poly(ethylene glycol) monomethyl ether is used to stabilize solutions and dispersions in laboratory settings.

Poly(ethylene glycol) monomethyl ether applied in the functionalization and modification of nanoparticles, particularly in the medical and materials science fields.
Certain PEG derivatives, including Poly(ethylene glycol) monomethyl ether, are used as contrast agents in medical imaging techniques like MRI.
Poly(ethylene glycol) monomethyl ether is used in the development of biomaterials for tissue engineering and drug delivery.

Poly(ethylene glycol) monomethyl ether derivatives are approved as food additives, stabilizers, and texturizing agents in certain food and beverage products.
Poly(ethylene glycol) monomethyl ether derivatives are investigated for their potential use in wastewater treatment due to their ability to adsorb contaminants and improve Poly(ethylene glycol) monomethyl ether can enhance the solubility of poorly water-soluble drugs, making them easier to formulate into medications.

Poly(ethylene glycol) monomethyl ether derivatives are often used in drug delivery systems to improve the release profile of drugs and increase their bioavailability.
Poly(ethylene glycol) monomethyl ether can be found in ointments, creams, and lotions due to its ability to improve the texture and spreadability of these products.
In the cosmetics and personal care industry, Poly(ethylene glycol) monomethyl ether is used for its emollient and solubilizing properties.

Poly(ethylene glycol) monomethyl ether can help stabilize oil-in-water emulsions, which are common in creams, lotions, and other cosmetic products.
Poly(ethylene glycol) monomethyl ether can act as a mild surfactant in cleansing products like shampoos, body washes, and facial cleansers.
Poly(ethylene glycol) monomethyl ether can be used in skincare products to provide moisturization and improve the texture of the product.

Poly(ethylene glycol) monomethyl ether is used in various industrial applications due to its solubility and non-reactive nature.
Poly(ethylene glycol) monomethyl ether can be used as a solvent or diluent in adhesive formulations.
Poly(ethylene glycol) monomethyl ether can contribute to the properties of coatings, such as improved flow and leveling.

In laboratory settings, Poly(ethylene glycol) monomethyl ether might be used as a component in various solutions or as a stabilizing agent.
Poly(ethylene glycol) monomethyl ether nanoparticles are utilized for targeted drug delivery, enhancing drug accumulation in specific tissues while minimizing side effects.
Poly(ethylene glycol) monomethyl ether is used in textile dyeing and finishing processes to enhance dye penetration and improve fabric properties.

Poly(ethylene glycol) monomethyl ether and other PEG derivatives are used as stabilizers and excipients in a wide range of products.
Poly(ethylene glycol) monomethyl ether derivatives are approved for use as food additives and stabilizers in certain food and beverage products.
Poly(ethylene glycol) monomethyl ether derivatives can serve as emulsifiers, thickeners, and stabilizers in cosmetics, skincare products, and toiletries.

Poly(ethylene glycol) monomethyl ether can be used in pesticide formulations to improve the dispersion of active ingredients and enhance their effectiveness.
Poly(ethylene glycol) monomethyl ether can be added to paint formulations to improve the stability of pigments, enhance paint flow, and reduce defects.
Poly(ethylene glycol) monomethyl ether can be present in household cleaners and disinfectants, aiding in solubilizing active ingredients and improving cleaning performance.

Poly(ethylene glycol) monomethyl ether's used in some personal hygiene products like soaps and hand sanitizers for its emulsifying and cleansing properties.
Poly(ethylene glycol) monomethyl ether can be used in industrial degreasing formulations due to its ability to solubilize oils and greases.
Poly(ethylene glycol) monomethyl ether is used in textile dyeing and printing processes to improve dye dispersion and color uptake.

Poly(ethylene glycol) monomethyl ether can assist in leather processing by facilitating the absorption of dyes and finishing agents.
Poly(ethylene glycol) monomethyl ether can be employed in the production of food packaging materials, helping improve their properties such as flexibility and moisture resistance.
Poly(ethylene glycol) monomethyl ether, research laboratories, PEG Monomethyl Ether may be used as a component of reagents for various experiments and studies.

In vaccine development, PEG derivatives are used as adjuvants and formulation aids to enhance immune responses and improve vaccine stability.
Poly(ethylene glycol) monomethyl ether derivatives may be used in drilling fluids in the oil and gas industry to control rheological properties and improve fluid stability.
Poly(ethylene glycol) monomethyl ether can be used in paper coating formulations to improve printability, ink absorption, and surface smoothness.

Poly(ethylene glycol) monomethyl ether can be used as additives in cement and mortar formulations to improve workability and water retention.
Poly(ethylene glycol) monomethyl ether can be incorporated into metalworking fluids to enhance lubrication and cooling properties during machining processes.

Poly(ethylene glycol) monomethyl ether used as a solubilizer to enhance the solubility of poorly water-soluble drugs.
Poly(ethylene glycol) monomethyl ether incorporated into drug delivery systems to improve drug release profiles.
Poly(ethylene glycol) monomethyl ether found in skincare products like lotions and creams for its emollient properties.

Poly(ethylene glycol) monomethyl ether is used as an ingredient in shampoos, body washes, and other cleansing products due to its mild surfactant properties.
Poly(ethylene glycol) monomethyl ether is included in cosmetics to enhance product texture and stability.
Poly(ethylene glycol) monomethyl ether is used in adhesives as a solvent or diluent.

Poly(ethylene glycol) monomethyl ether added to coatings to improve flow and leveling properties.
Poly(ethylene glycol) monomethyl ether is used in various laboratory applications as a component of solutions or as a stabilizing agent.

Safety Considerations:
Poly(ethylene glycol) monomethyl ether is generally considered safe when used within recommended concentrations and guidelines.
However, as with any chemical substance, safety precautions should be taken.
Skin sensitization or irritation might occur in some individuals, so patch testing is advisable, especially in cosmetic and personal care applications.

Poly(ethylene glycol) monomethyl ether, especially in its concentrated form, can cause skin irritation in some individuals.
Sensitization reactions, where the skin becomes hypersensitive upon repeated exposure, can occur in susceptible individuals.
Poly(ethylene glycol) monomethyl ether can cause irritation to the eyes upon direct contact.

In case of eye contact, thorough rinsing with water is recommended.
Inhalation of vapor, mist, or aerosolized forms of Poly(ethylene glycol) monomethyl ether should be minimized, especially in confined spaces without proper ventilation
Some individuals may be allergic to Poly(ethylene glycol) monomethyl ether, which can lead to various adverse reactions upon exposure.

Poly(ethylene glycol) monomethyl ether is generally considered to have low toxicity, its presence in the environment could potentially contribute to pollution, especially if not properly managed.
Biodegradability varies among Poly(ethylene glycol) monomethyl ether derivatives, and those with higher molecular weights might be less biodegradable.

Synonyms
(C2-H4-O)mult-C-H4-O
9004-74-4
Carbowax Sentry Methoxypolyethylene Glycol
Ethylene oxide adduct of diethylene glycol monomethyl ether
Glycols, monomethyl ether
MPEG
Methoxy polyethylene glycol
Monomethoxypolyethylene glycol
PEG-6 METHYL ETHER
Poly(ethylene glycol methyl ether)
Poly(oxy- 1, 2- ethanediyl), a- methyl- ?- hydroxy-
Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-hydroxy-
Poly(oxy-1,2-ethanediyl), ?-methyl-?-hydroxy-
Poly(oxy-1,2-ethanediyl), alpha-methyl-omega-hydroxy
Polyethylene glycol methyl ether
Polyethylene glycol monomethyl ether
Polyethylene glycol monomethyl ether [NF]
Polyethylene glycol, monomethyl ether
UNII-6AXS45P1QU
UNII-89ES36762B
UNII-ENK4Y6S66X
UNII-H0S96329MO
UNII-P3R1BUP13I
UNII-UQE3488NAI
UNII-WXH089JZ5E
POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB)
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer applied as a disinfectant and antiseptic.


CAS Number: 32289-58-0; 27083-27-8
EC Number: 1308068-626-2
Chemical Name:Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride
Chemical Formula: (C8H17N5)n•(HCl)x



SYNONYMS:
biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB (Poly Hexa Methylene Biguanide), Polyhexamethylene biguanidine Hydrochloride, Pure Polyhexamethylene biguanide Hydrochloride (PHMB) CAS 32289-58-0, Poly(hexamethylenebiguanide) Hcl, Poly(hexamethylenebiguanide)hydrochloride,
Polyhexamethylene biguanide, Polyhexamethylene guanide, Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride, Poly(hexamethylenebiguanide), Polihexanide, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride, biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB(Poly Hexa Methylene Biguanide), Polyhexanide hydrochloride, Polyhexamethylene biguanide hydrochloride, 1-(diaminomethylidene)-2-hexylguanidine hydrochloride, PHMB; Polyhexamethylene biguanide, Poly(hexamethylene) biguanide hydrochloride, Polyhexamethylene biguanide hydrochloride, Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride, N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride, biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB (Poly Hexa Methylene Biguanide), Polyhexamethylene biguanidine Hydrochloride, Pure Polyhexamethylene biguanide Hydrochloride (PHMB) CAS 32289-58-0, Poly(hexamethylenebiguanide) Hcl, Poly(hexamethylenebiguanide)hydrochloride,
Polyhexamethylene biguanide, Polyhexamethylene guanide, Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride, Poly(hexamethylenebiguanide), Polihexanide, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride, biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB(Poly Hexa Methylene Biguanide), Polyhexanide hydrochloride, Polyhexamethylene biguanide hydrochloride, 1-(diaminomethylidene)-2-hexylguanidine hydrochloride, PHMB; Polyhexamethylene biguanide, Poly(hexamethylene) biguanide hydrochloride, Polyhexamethylene biguanide hydrochloride, Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride, N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB(Poly Hexa Methylene Biguanide), Polyhexamethylene biguanidine Hydrochloride,




Poly(hexamethylene biguanide) hydrochloride (PHMB) is a colorless or light yellow transparent liquid, in which the guanidine group has high activity, which can make the polymer into a positive charge, and it is easily attacked by various negatively charged bacteria and bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a colorless or light yellow transparent liquid, in which the guanidine group has high activity, which can make the polymer into a positive charge, and it is easily attacked by various negatively charged bacteria and bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a colorless or light yellow transparent liquid, in which the guanidine group has high activity, which can make the polymer into a positive charge, and it is easily attacked by various negatively charged bacteria and bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.


The presence of multiple hydrogen bond and chelation sites within Poly(hexamethylene biguanide) hydrochloride (PHMB) renders it of potential interest to those studying supramolecular chemical effects.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is available also as 20% aqueous solution.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer applied as a disinfectant and antiseptic.
In dermatological use, Poly(hexamethylene biguanide) hydrochloride (PHMB) is also called polihexanide.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is very effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is an antimicrobial agent that kills or inhibits the growth of bacteria, fungi, and other microorganisms.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also effective against a wide range of viruses, including influenza and hepatitis.
Poly(hexamethylene biguanide) hydrochloride (PHMB) has been used in wet wipes for many years and is considered to be safe and effective.


The bactericidal ability of Poly(hexamethylene biguanide) hydrochloride (PHMB) is better than other bactericides.
In particular, Poly(hexamethylene biguanide) hydrochloride (PHMB)'s unique long-term antibacterial effect and the ability to prevent secondary infection are not achieved by other fungicides.


The presence of multiple hydrogen bond and chelation sites within Poly(hexamethylene biguanide) hydrochloride (PHMB) renders it of potential interest to those studying supramolecular chemical effects.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is available also as 20% aqueous solution.


The solution of Poly(hexamethylene biguanide) hydrochloride (PHMB) is an important ingredient in some pharmaceutical or veterinary formulations.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.


The presence of multiple hydrogen bond and chelation sites within Poly(hexamethylene biguanide) hydrochloride (PHMB) renders it of potential interest to those studying supramolecular chemical effects.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is available also as 20% aqueous solution.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is best known for its broad-spectrum antimicrobial and antifungal activity.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer applied as a disinfectant and antiseptic.
In dermatological use, Poly(hexamethylene biguanide) hydrochloride (PHMB) is also called polihexanide.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is very effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a disinfectant and antiseptic.


Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer applied as a disinfectant and antiseptic.


The solution of Poly(hexamethylene biguanide) hydrochloride (PHMB) is an important ingredient in some pharmaceutical or veterinary formulations.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.


The presence of multiple hydrogen bond and chelation sites within Poly(hexamethylene biguanide) hydrochloride (PHMB) renders it of potential interest to those studying supramolecular chemical effects.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is available also as 20% aqueous solution.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is best known for its broad-spectrum antimicrobial and antifungal activity.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a disinfectant and antiseptic.


Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).



USES and APPLICATIONS of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) can completely kill escherichia coli, staphylococcus aureus, candida Albicans, gonococcus, salmonella, pseudomonas aeruginosa, listeria, dysentery, aspergillus niger, brucella, vibrio parahaemolyticus, vibrio algolyticus, vibrio eelis, Aeromonas hydrophilus, sulfate-reducing bacteria, iron bacteria, and saprophytic bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is suitable to care solutions for contact lenses, cosmetics, medical, pharmaceuticals, skin, mucosa, vegetable, fruit, air, drinking water, swimming pool, paper making, tissue, anitary pads, clothes, etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be widely used in textile, animal husbandry, aquaculture, medical sterilization, and daily disinfectant.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be widely applied in the fields of daily chemical industry, water treatment, textile, papermaking, petroleum, agriculture, husbandry, health care etc.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can completely kill escherichia coli, staphylococcus aureus, candida Albicans, gonococcus, salmonella, pseudomonas aeruginosa, listeria, dysentery, aspergillus niger, brucella, vibrio parahaemolyticus, vibrio algolyticus, vibrio eelis, Aeromonas hydrophilus, sulfate-reducing bacteria, iron bacteria, and saprophytic bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is suitable to care solutions for contact lenses, cosmetics, medical, pharmaceuticals, skin, mucosa, vegetable, fruit, air, drinking water, swimming pool, paper making, tissue, anitary pads, clothes, etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be widely used in textile, animal husbandry, aquaculture, medical sterilization, and daily disinfectant.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be widely applied in the fields of daily chemical industry, water treatment, textile, papermaking, petroleum, agriculture, husbandry, health care etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is often used as sanitary wet wipe bactericides, fruit, vegetable and aquatic product disinfectants, sewage treatment flocculation disinfectants etc.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
As a sanitizer, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.


As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in environmental disinfection including hospitals, schools, hotels, and public places.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
As a sanitizer, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as a disinfectant and antiseptic.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as fungicides, bactericides mainly used in swimming pools, universal cleaning agents and disinfectants.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in health care, chemicals, textiles, paper, wipes, livestock, aquaculture, fisheries, plastics, agriculture, water treatment and other fields.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used directly after dilution with purified water or with other additive agent compound.
Since Poly(hexamethylene biguanide) hydrochloride (PHMB) in different areas of application, the product dosage are quite different, it is recommended to use under the guidance of our professional and technical persons.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as a sanitizer or preservative to kill bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) restrains the gram-positive bacterium, gram-negative bacterium, fungus and yeast etc.
As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contactlens solutions, hand washes, and more.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is also widely used in evironmental disinfection including hospitals, schools, hotels, and public places.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, the preservation of fruit and vegetables.
As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in environmental disinfection including hospitals, schools, hotels, and public places.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.


As a sanitizer, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.


As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in environmental disinfection including hospitals, schools, hotels, and public places.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as a disinfectant and antiseptic.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as fungicides, bactericides mainly used in swimming pools, universal cleaning agents and disinfectants.


As a medicinal product, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used for disinfection of contact lenses, eye drops, and surgical procedures.
Due to the strong tolerance of the eyes to Poly(hexamethylene biguanide) hydrochloride (PHMB).
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as a drug for the treatment of Acanthopanaxa Miba keratitis and the prevention and treatment of other eye diseases.


At the same time, Poly(hexamethylene biguanide) hydrochloride (PHMB) is also widely used in cosmetics, personal care products, textiles, food industries, etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.
As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in health care, chemicals, textiles, paper, wipes, livestock, aquaculture, fisheries, plastics, agriculture, water treatment and other fields.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in environmental disinfection including hospitals, schools, hotels, and public places.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely utilized as a disinfectant in personal care commodities like cosmetics and toiletries and as a sanitizer in swimming pools.


Poly(hexamethylene biguanide) hydrochloride (PHMB) possesses marked characteristics of cationic polyelectrolyte.
There are also unique determination methods to Poly(hexamethylene biguanide) hydrochloride (PHMB) using its ion association with organic anions and polyanion.


As a sanitizer, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used directly after dilution with purified water or with other additive agent compound.
Since Poly(hexamethylene biguanide) hydrochloride (PHMB) in different areas of application, the product dosage are quite different, it is recommended to use under the guidance of our professional and technical persons.


Another good application of Poly(hexamethylene biguanide) hydrochloride (PHMB) is that it is widely used as a swimming-pool and spa water sanitizer instead of chlorine- or bromine-based commodities.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also utilized as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.


As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is utilized in chemical products like cosmetics, personal care products, fabric softeners, contactlens solutions, hand washes, and so on.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is applied as a sanitizer or preservative to kill bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) restrains the gram-positive bacterium, gram-negative bacterium, fungus and yeast, and so on.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also commonly applied in eviromental disinfection area, such as in hospitals, schools, hotels, and a lot of other public sites.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a sanitizer or preservative to kill bacteria.
As a sanitizer, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is often used as sanitary wet wipe bactericides, fruit, vegetable and aquatic product disinfectants, sewage treatment flocculation disinfectants etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a synthetic polymer that is used in a variety of consumer and industrial products, including wet wipes.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.


As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in environmental disinfection including hospitals, schools, hotels, and public places.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used to preserve wet wipes; to control odor in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, farm equipment, animal drinking water, and hard surfaces for food handling institutions and hospitals; and to deodorize vacuums and toilets.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant,etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in health care, chemicals, textiles, paper, wipes, livestock, aquaculture, fisheries, plastics, agriculture, water treatment and other fields.


Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used directly after dilution with purified water or with other additive agent compound.
Since Poly(hexamethylene biguanide) hydrochloride (PHMB) in different areas of application, the product dosage are quite different, it is recommended to use under the guidance of our professional and technical persons.


As a medicinal product, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used for disinfection of contact lenses, eye drops, and surgical procedures.
Due to the strong tolerance of the eyes to Poly(hexamethylene biguanide) hydrochloride (PHMB).
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as a drug for the treatment of Acanthopanaxa Miba keratitis and the prevention and treatment of other eye diseases.


At the same time, Poly(hexamethylene biguanide) hydrochloride (PHMB) is also widely used in cosmetics, personal care products, textiles, food industries, etc.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.
As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.


Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in environmental disinfection including hospitals, schools, hotels, and public places.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely utilized as a disinfectant in personal care commodities like cosmetics and toiletries and as a sanitizer in swimming pools.


Poly(hexamethylene biguanide) hydrochloride (PHMB) possesses marked characteristics of cationic polyelectrolyte.
There are also unique determination methods to Poly(hexamethylene biguanide) hydrochloride (PHMB) using its ion association with organic anions and polyanion.


As a sanitizer, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets.


Another good application of Poly(hexamethylene biguanide) hydrochloride (PHMB) is that it is widely used as a swimming-pool and spa water sanitizer instead of chlorine- or bromine-based commodities.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also utilized as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.


As a preservative, Poly(hexamethylene biguanide) hydrochloride (PHMB) is utilized in chemical products like cosmetics, personal care products, fabric softeners, contactlens solutions, hand washes, and so on.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is applied as a sanitizer or preservative to kill bacteria.


Poly(hexamethylene biguanide) hydrochloride (PHMB) restrains the gram-positive bacterium, gram-negative bacterium, fungus and yeast, and so on.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also commonly applied in eviromental disinfection area, such as in hospitals, schools, hotels, and a lot of other public sites.



PROPERTIES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a water solution that can be used as a broad-spectrum and high efficiency disinfectant.

Poly(hexamethylene biguanide) hydrochloride (PHMB) is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of Poly(hexamethylene biguanide) hydrochloride (PHMB)'s special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.

Poly(hexamethylene biguanide) hydrochloride (PHMB) is a high molecular polymer, which is easy to be washed away.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to the skin, and can not be easily absorbed by human organs.
Vitro studies show that Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-toxic to human cells.



FEATURES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
*Broad spectrum kills and inhibits various types of microbial.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is odorless and can be easily dissolved in water to form a tasteless colorless transparent solution.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as a disinfectant for almost all kinds of bacteria.

*Excellent stability:
Poly(hexamethylene biguanide) hydrochloride (PHMB) is still kept active after being heated at 280℃ for 15 min.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to metals.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to copper, stainless steel, carbon steel, and other metals.



STERILIZATION MECHANISM OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
1. The guanidine group in Poly(hexamethylene biguanide) hydrochloride (PHMB) performs a high activity and the polymer itself is cationic.
Since bacteria and viruses are usually anionic, they are easy to be absorbed by Poly(hexamethylene biguanide) hydrochloride (PHMB) and could not divide and reproduce, and finally turn inactive.

2. Poly(hexamethylene biguanide) hydrochloride (PHMB) collapses the cell membrane structure and forms transmembrane stomata.
Ultimately, Poly(hexamethylene biguanide) hydrochloride (PHMB) causes cell membrane rupture, disrupts the energy metabolism of the organism, and disables bacteria and viruses.

3. Poly(hexamethylene biguanide) hydrochloride (PHMB) forms a film that closes off the breathing passages of microorganisms, causing them to suffocate and die.
The sterilization mechanism is independent of the form and type of microorganisms.
Even if the microorganisms mutate, the mutation will not affect their efficacy.
Microorganisms do not produce resistance to Poly(hexamethylene biguanide) hydrochloride (PHMB).



STORAGE OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) should be sealed and shaded to be stored in a dry, cool, well ventilated place.



PERFORMANCE FEATURES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) is recognized as the safest and the most efficient broad-spectrum antibacterial agent in the 21st century.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is colorless and tasteless, low bacterial inhibition concentration, broad spectrum, low toxicity.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can form a layer of cations on the surface of article, which can inhibit bacteria for a long time.
Poly(hexamethylene biguanide) hydrochloride (PHMB) also has no bacteria drug resistance.



PROPERTIES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a water solution that can be used as a broad-spectrum and high efficiency disinfectant.

Poly(hexamethylene biguanide) hydrochloride (PHMB) is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of Poly(hexamethylene biguanide) hydrochloride (PHMB)'s special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.

Poly(hexamethylene biguanide) hydrochloride (PHMB) is a high molecular polymer, which is easy to be washed away.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to the skin, and can not be easily absorbed by human organs.
Vitro studies show that Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-toxic to human cells.



FEATURES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
*Broad spectrum kills and inhibits various types of microbial.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is odorless and can be easily dissolved in water to form a tasteless colorless transparent solution.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as a disinfectant for almost all kinds of bacteria.

*Excellent stability:
Poly(hexamethylene biguanide) hydrochloride (PHMB) is still kept active after being heated at 280℃ for 15 min.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to metals.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to copper, stainless steel, carbon steel, and other metals.



PROPERTIES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a water solution that can be used as a broad-spectrum and high-efficiency disinfectant.

Poly(hexamethylene biguanide) hydrochloride (PHMB) is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of Poly(hexamethylene biguanide) hydrochloride (PHMB)'s special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.

Poly(hexamethylene biguanide) hydrochloride (PHMB) disinfectant is a high molecular polymer, which is easy to be washed away.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to skin, and can not be easily absorbed by human organs.
Vitro studies show that Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-toxic to human cells.

Skin irritancy test shows that Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-irritant to animal and human skin.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be widely used in textile, animal husbandry, aquiculture, medical sterilization, and daily disinfectant.



PERFORMANCE FEATURES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) is recognized as the safest and the most efficient broad-spectrum antibacterial agent in the 21st century.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is colorless and tasteless, low bacterial inhibition concentration, broad spectrum, low toxicity.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can form a layer of cations on the surface of article, which can inhibit bacteria for a long time.
Poly(hexamethylene biguanide) hydrochloride (PHMB) also has no bacteria drug resistance.



PROPERTIES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a water solution that can be used as a broad-spectrum and high-efficiency disinfectant.

Poly(hexamethylene biguanide) hydrochloride (PHMB) is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of Poly(hexamethylene biguanide) hydrochloride (PHMB)'s special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.

Poly(hexamethylene biguanide) hydrochloride (PHMB) disinfectant is a high molecular polymer, which is easy to be washed away.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-corrosive to skin, and can not be easily absorbed by human organs.
Vitro studies show that Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-toxic to human cells.

Skin irritancy test shows that Poly(hexamethylene biguanide) hydrochloride (PHMB) is non-irritant to animal and human skin.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be widely used in textile, animal husbandry, aquiculture, medical sterilization, and daily disinfectant.



SYNTHESIS OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB) ANTIMICROBIAL:
*Adopt the melt polycondensation method.
Put the appropriate amount of guanidine hydrochloride and 1, 6-hexane-diamine in the polymerization kettle, stir, and raise the temperature.
After the reactants are completely melted, continue to raise the temperature, constant temperature reaction for about 2h.

And then raise the temperature to a predetermined temperature for the reaction.
After the reaction is finished, stop stirring, and pass nitrogen gas into the kettle.
Open the discharge port at the same time.

Let the product flow into the pre-prepared container.
Let Poly(hexamethylene biguanide) hydrochloride (PHMB) cool down and solidify, then crush it for use.
By following the above procedure, theoretically, a bulk polymer can be produced.

But in practice, due to the difference in the reactivity of the functional groups, will produce an insoluble cross-linked structure, cross-linked polymers are insoluble, and not conducive to melt processing, but as long as the appropriate reaction conditions can be controlled to obtain linear high molecular weight products.



STERILIZATION MECHANISM OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
1. The guanidine group in Poly(hexamethylene biguanide) hydrochloride (PHMB) performs a high activity and the polymer itself is cationic.
Since bacteria and viruses are usually anionic, they are easy to be absorbed by Poly(hexamethylene biguanide) hydrochloride (PHMB) and could not divide and reproduce, and finally turn inactive.

2. Poly(hexamethylene biguanide) hydrochloride (PHMB) collapses the cell membrane structure and forms transmembrane stomata.
Ultimately, Poly(hexamethylene biguanide) hydrochloride (PHMB) causes cell membrane rupture, disrupts the energy metabolism of the organism, and disables bacteria and viruses.

3. Poly(hexamethylene biguanide) hydrochloride (PHMB) forms a film that closes off the breathing passages of microorganisms, causing them to suffocate and die.
The sterilization mechanism is independent of the form and type of microorganisms.
Even if the microorganisms mutate, the mutation will not affect their efficacy.
Microorganisms do not produce resistance to Poly(hexamethylene biguanide) hydrochloride (PHMB).



STORAGE OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Poly(hexamethylene biguanide) hydrochloride (PHMB) should be sealed and shaded to be stored in a dry, cool, well ventilated place.



SYNTHESIS OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB) ANTIMICROBIAL:
*Adopt the melt polycondensation method.
Put the appropriate amount of guanidine hydrochloride and 1, 6-hexane-diamine in the polymerization kettle, stir, and raise the temperature.
After the reactants are completely melted, continue to raise the temperature, constant temperature reaction for about 2h.

And then raise the temperature to a predetermined temperature for the reaction.
After the reaction is finished, stop stirring, and pass nitrogen gas into the kettle.
Open the discharge port at the same time.

Let the product flow into the pre-prepared container.
Let Poly(hexamethylene biguanide) hydrochloride (PHMB) cool down and solidify, then crush it for use.
By following the above procedure, theoretically, a bulk polymer can be produced.

But in practice, due to the difference in the reactivity of the functional groups, will produce an insoluble cross-linked structure, cross-linked polymers are insoluble, and not conducive to melt processing, but as long as the appropriate reaction conditions can be controlled to obtain linear high molecular weight products.



SPECIAL APPLICATIONS OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
1. Paper making industry:
In the process of papermaking and cardboard production, because Poly(hexamethylene biguanide) hydrochloride (PHMB) is cationic polymer electrolyte, it can be used as an auxiliary agent to accelerate pulp dehydration and mineral filler precipitation, so as to strengthen and improve papermaking process.

In addition, Poly(hexamethylene biguanide) hydrochloride (PHMB) can also stabilize the dispersion of paraffin and increase the size stability of paper.
The hydrophobicity of paper and hardboard paper increases by 40-50%.

The activity also reduces some problems related to the accumulation of pulp in papermaking machinery, and Poly(hexamethylene biguanide) hydrochloride (PHMB) can produce antibacterial paper for manufacturing health products (to replace the silver containing kursin paper).
At the same time, Poly(hexamethylene biguanide) hydrochloride (PHMB) also improves the physical properties of the paper: water absorption, strength after water, air permeability.


2. Agricultural application:
As Poly(hexamethylene biguanide) hydrochloride (PHMB) has the function of disease resistance and protection to plants, can effectively kill harmful bacteria, and is harmless to ecology, it is an environmental protection product, which makes the product completely applicable to all growth stages of various agricultural products: Treat seeds, bulbs or tubular seeds with 0.1-1% aqueous solution of Poly(hexamethylene biguanide) hydrochloride (PHMB).

When the symptoms of vegetable diseases appear, spray with 0.01-0.1% Poly(hexamethylene biguanide) hydrochloride (PHMB) aqueous solution of the product (if necessary, add appropriate polyelectrolyte, such as polyacrylic acid).

In order to reduce the loss of storage in winter, 0.2% Poly(hexamethylene biguanide) hydrochloride (PHMB) aqueous solution of this product can be used to wash or spray vegetables and fruits.
In addition, Poly(hexamethylene biguanide) hydrochloride (PHMB) can overcome the damage of excessive herbicides to plants and prevent infection in the soil.

As a pesticide, the efficacy of Poly(hexamethylene biguanide) hydrochloride (PHMB) is ten times higher than that of Benazolin, chlorothalonil and sodium disulfonate.
Therefore, to achieve the same effect, the use amount of Poly(hexamethylene biguanide) hydrochloride (PHMB) 20% liquid is 10-30 times less.
Moreover, Poly(hexamethylene biguanide) hydrochloride (PHMB) is safe, non-toxic and non irritating, especially harmless to people and animals.


3. Oil exploitation:
In oil exploitation, a large number of bacteria, such as sulfate reducing bacteria, not only engulf the oil, but also degrade the polymer used (ordinary polymer with low molecular weight), reducing the efficiency of polymer flooding and increasing the cost.



BACTERICIDAL MECHANISM OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
Bacteria quickly suffocate to death after using Poly(hexamethylene biguanide) hydrochloride (PHMB).
At the same time, because this product is a polymer structure, which can improve the effective activity of guanidine group, the bactericidal effect of Poly(hexamethylene biguanide) hydrochloride (PHMB) is much higher than other guanidine compounds (such as chlorhexidine).
Due to the special bactericidal mechanism of this product, all kinds of bacteria will not be resistant to Poly(hexamethylene biguanide) hydrochloride (PHMB), which has been confirmed by the experiments of foreign authoritative testing institutions.



FEATURES AND ADVANTAGES OF POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
1. Long-acting nature:
After the solution of Poly(hexamethylene biguanide) hydrochloride (PHMB) is dried, a polymer thin layer of disinfectant is formed on the surface of the object, which can keep the state of the object after sterilization and prevent the secondary pollution of the object.
Generally, the surfaces treated with aqueous solution of Poly(hexamethylene biguanide) hydrochloride (PHMB) will remain sterile for up to three months.


2. Innocuity
As Poly(hexamethylene biguanide) hydrochloride (PHMB) is a high polymer, it is not easy to be absorbed by animal tissues, greatly reducing the toxicity, so that it has no effect on cells of higher organisms.
In addition, the experiment proves that Poly(hexamethylene biguanide) hydrochloride (PHMB) can be naturally degraded and will not cause pollution to the environment.
The conclusion is that "2% of Poly(hexamethylene biguanide) hydrochloride (PHMB) belongs to the actual non-toxic grade".


3. No irritation to skin:
The experimental study of Poly(hexamethylene biguanide) hydrochloride (PHMB) on skin was carried out with rabbits.
Conclusion: 2% of Poly(hexamethylene biguanide) hydrochloride (PHMB) has no skin irritation when the skin irritation response integral value is 0. (judgment standard: the lower the integral value, the lower the stimulation.)



PHYSICAL and CHEMICAL PROPERTIES of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
CAS No.: 32289-58-0
Molecular Formula: (C8H18N5Cl)n n=12-16
Appearance: White powder, colorless translucent crystals, colorless liquid
Purity: 95%, 98%, ≥98%, 20%, 25%, 50%
Density (20℃): 1.039~1.046g/cm3
pH value (20℃): 4.0~6.0
Absorbance (237nm): ≥400
Absorbance (237nm/222nm): 1.2~1.6
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB)
CAS 32289-58-0
Poly(hexamethylenebiguanide) Hcl
Content (wt%): 20
Water (wt%): 80 max.
Total metal (ppm): 100 max.
Odor: No odor

Boiling point (°C): 102-103
Specific gravity @25°C (g/cm3): 1.03-1.05
Solubility in water (20°C): Very good
HS Code: 29121900
Color of Liquid: Clear to Slight Haze
Water Solubility: Miscible
Application: Biocides, Water Treatment, Disinfectant
Appearance: Colorless or light-yellow solid
Active ingredient: ≥99%
Water soluble: 100% soluble
Odor: Light ammonia smell
Moisture content: ≤0.5%
Water insoluble matter: ≤0.1%
PH in 1% aqueous solution: >4
Ash: 0.05%
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB)

CAS: 32289-58-0 Poly(hexamethylenebiguanide) Hcl
Appearance: slightly yellow to colorless & clear
Content (wt%): 20
Water (wt%): 80max.
Total metal (ppm): 100max
Ordor: no ordor. PH (20% water): 3.0-5.5
Boling point(°C): 102-103
Specific gravity @25°C (g/cm3):1.03-1.05
Solubility in water (20°C): very good
Appearance: Colorless or pale-yellow transparent liquid
Boiling point(℃): 102
Content (%): 19.0-21.0
Relative density(g/ml,25℃): 1.04
pH: 4.0-6.0
Name: Polyhexamethylene biguanide hydrochloride; PHMB
CAS No.: 32289-58-0
Formula: (C8H17N5)n•xHCl
Molecular Weight: ≥1,600~2,600

CAS: 32289-58-0 Poly(hexamethylenebiguanide) Hcl
Appearance: slightly yellow to colorless & clear
Content (wt%): 20
Water (wt%): 80max.
Total metal (ppm): 100max
Ordor: no ordor. PH (20% water): 3.0-5.5
Boling point(°C): 102-103
Specific gravity @25°C (g/cm3):1.03-1.05
Solubility in water (20°C): very good
Appearance: Colorless or pale-yellow transparent liquid
Boiling point(℃): 102
Content (%): 19.0-21.0
Relative density(g/ml,25℃): 1.04
pH: 4.0-6.0
Name: Polyhexamethylene biguanide hydrochloride; PHMB
CAS No.: 32289-58-0
Formula: (C8H17N5)n•xHCl
Molecular Weight: ≥1,600~2,600

CAS No.: 32289-58-0
Molecular Formula: (C8H18N5Cl)n n=12-16
Appearance: White powder, colorless translucent crystals, colorless liquid
Purity: 95%, 98%, ≥98%, 20%, 25%, 50%
Density (20℃): 1.039~1.046g/cm3
pH value (20℃): 4.0~6.0
Absorbance (237nm): ≥400
Absorbance (237nm/222nm): 1.2~1.6
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB)
CAS 32289-58-0
Poly(hexamethylenebiguanide) Hcl
Content (wt%): 20
Water (wt%): 80 max.
Total metal (ppm): 100 max.
Odor: No odor

Boiling point (°C): 102-103
Specific gravity @25°C (g/cm3): 1.03-1.05
Solubility in water (20°C): Very good
HS Code: 29121900
Color of Liquid: Clear to Slight Haze
Water Solubility: Miscible
Application: Biocides, Water Treatment, Disinfectant
Appearance: Colorless or light-yellow solid
Active ingredient: ≥99%
Water soluble: 100% soluble
Odor: Light ammonia smell
Moisture content: ≤0.5%
Water insoluble matter: ≤0.1%
PH in 1% aqueous solution: >4
Ash: 0.05%
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB)



FIRST AID MEASURES of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
-Environmental precautions
Do not let product enter drains.
-Methods and materials for containment and cleaning up
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media.
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Respiratory protection
Recommended Filter type: Filter type P1
-Control of environmental exposure
Do not let product enter drains.



HANDLING and STORAGE of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of POLY(HEXAMETHYLENE BIGUANIDE) HYDROCHLORIDE (PHMB):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available


POLY(HEXAMETHYLENEBIGUANIDE)
Poly(hexamethylenebiguanide) is a polymer used as a disinfectant and antiseptic.
Poly(hexamethylenebiguanide) is non-oxidising, cationic in solution in water and can be an alternative to other cationic biocidal treatments based on quaternary ammonium or chlorine.



CAS Number: 28757-47-3
EC Number: 923-111-4
MDL Number: MFCD00217750
Molecular Formula: C8H19N5



SYNONYMS:
Polyhexamethylene biguanide, Polyhexamethylene guanide, Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride, Poly(hexamethylenebiguanide), Polihexanide, polyhexamethylene biguanide, Baquacil, EPA Pesticide Chemical Code 111801, Polyhexamethylene biguanide, SRU, Sanitized T 96-04, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene), polyhexamethylene biguanide, Baquacil, EPA Pesticide Chemical Code 111801, Polyhexamethylene biguanide, SRU, Sanitized T 96-04, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene), Baquacil, cosmocil, Lavasept, PHMB polymer, polihexanide, polihexanide hydrochloride, poly(hexamethylene biguanide), poly(hexamethylenebiguanide) hydrochloride, poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride, polyhexamethylen-biguanide, polyhexamethylenbiguanid, polyhexamethylenbiguanide, polyhexamethylene biguanide, polyhexamethylene biguanide hydrochloride, polyhexanide, Vantocil, Vantocil IB, Vantocil, Polyhexidine, Polyxedinine, Polyhexanide, Sanitized T 96-04, Hexyl biguanide HCl, OLIGOHEXAMETHYLENEBIGUANIDE, Polyhexamethylene biguanide, sru, Epa pesticide chemical code 111801, 1-(diaminomethylidene)-2-hexylguanidine, POLY(IMINOIMIDOCARBONYLIMINOIMIDOCARBONYLIMINOHEXAMETHYLENE), Polihexanide, PHMB, Polyhexanide, 322U039GMF, Polihexanidum, Cosmoquil CQ, Prontoderm, Prontosan, Reputex 20, Trigene, Vantocil 1B, Vantocil TG, Vantosan, Caswell No. 676, Disinfecting Wet Wipe, EPA Pesticide Chemical Code 111801, PHMB Disinfectant, PP 073, Polihexanido, Proxel IBCN Reputex 20CN Trigene, DTXSID2035726, Disposable Spray Disinfectant, HBA Anti bacterial Liquid, HBA Sanitary Wipes, HSDB 8471, MICROCARE MBG, PHMB polymer, POLIHEXANIDE (MART.), PURISTA, Polihexanido (INN-Spanish), Polihexanidum (INN-Latin), UNII-4XI6112496, poly(hexamethylene biguanide), polyhexamethylen-biguanide, polyhexamethylenbiguanid, polyhexamethylenbiguanide, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene), Polyhexamethylene biguanide SRU, Sanitized T 96-04, Poly(hexamethylenebiguanide), Hexamethylenebis(cyanoguanidine)-hexamethylenediamine copolymer SRU, Eyeness, Complete Protec, NB 325, Texguard 20, Cosmocil 100, Polyhexamethylene biguanidine, Complete Protec, Epa pesticide chemical code 111801, Eyeness, Hexamethylenebis(cyanoguanidine)-hexamethylenediamine copolymer SRU, NB 325, OLIGOHEXAMETHYLENEBIGUANIDE, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), POLY(IMINOIMIDOCARBONYLIMINOIMIDOCARBONYLIMINOHEXAMETHYLENE), Polyhexamethylene biguanide, Polyhexamethylene biguanide sru, Polyhexanide, Polyhexidine, Polyxedinine, Sanitized T 96-04, Texguard 20, Polyhexamethylene biguanide, 1-(diaminomethylidene)-2-hexylguanidine, Baquacil, Cosmocil, Lavasept, Phmb Polymer, Polihexanide, Polihexanide Hydrochloride, Poly(hexamethylene Biguanide), Poly(hexamethylenebiguanide) Hydrochloride, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) Hydrochloride, Polyhexamethylen-biguanide, Polyhexamethylenbiguanid, Polyhexamethylenbiguanide, Polyhexamethylene Biguanide, Polyhexamethylene Biguanide Hydrochloride, Vantocil, Vantocil Ib Of Vantocil



Poly(hexamethylenebiguanide) is a chemical product created at the end of the 1950s and used since the 1970s in the formulation of certain biocides.
It is found in particular to kill microbes such as bacteria and viruses or fungi in water in the form of Poly(hexamethylenebiguanide) salt, a pesticide that can be used as a swimming pool disinfectant.


Poly(hexamethylenebiguanide) is a stable and therefore persistent product that remains effective in the presence of UV light and at different pH values.
Poly(hexamethylenebiguanide) is non-oxidising, cationic in solution in water and can be an alternative to other cationic biocidal treatments based on quaternary ammonium or chlorine.


Poly(hexamethylenebiguanide) is very effective compared to Benzalkonium Chloride.
Poly(hexamethylenebiguanide) is a polymer used as a disinfectant and antiseptic.
Poly(hexamethylenebiguanide) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.


Poly(hexamethylenebiguanide)-based MPS.
Most MPS contain Poly(hexamethylenebiguanide), which was originally developed as a presurgery antimicrobial scrub and then marketed for the sanitization of swimming pools and spas.


Poly(hexamethylenebiguanide) is part of the same pharmaceutical family as chlorhexidine, and is active against a wide range of bacteria.
The action of Poly(hexamethylenebiguanide) is thought to be due to its rapid attraction towards the negatively charged phospholipids at the bacterial cell surface, followed by impairment of membrane activity with the loss of potassium ions and the precipitation of intracellular constituents.


Poly(hexamethylenebiguanide) has a larger molecular weight than chlorhexidine, which means that it is not able to enter the matrix of soft lens materials.
Poly(hexamethylenebiguanide) is a highly water soluble and hydrolytically stable polymeric material.


The presence of multiple hydrogen bond and chelation sites within Poly(hexamethylenebiguanide) renders it of potential interest to those studying supramolecular chemical effects.
Poly(hexamethylenebiguanide) is available also as 20% aqueous solution.



USES and APPLICATIONS of POLY(HEXAMETHYLENEBIGUANIDE):
Poly(hexamethylenebiguanide) is used Paints, Adhesives, Leather processing solutions, Drilling fluids and oilfield injection waters, Latex polymers, Slurries and dispersions, Antimicrobial fabric conditioners and dishwashing liquids, and Surface disinfection.
Poly(hexamethylenebiguanide) is used - hospitals - algaecide for concrete surfaces - All-purpose ,surfaces disinfectant, hand bactericide, hand sanitizers.


Poly(hexamethylenebiguanide) is used including oil-in-water and water-in-oil emulsions.
Poly(hexamethylenebiguanide) is used personal care applications.
Poly(hexamethylenebiguanide) is used - cited in the European cosmetic directory.


Poly(hexamethylenebiguanide) is used water treatment - in swimming pools as an alternative to chlorine
Poly(hexamethylenebiguanide) is also found in some medicines in the form of polyhexamethylene biguanide hydrochloride.
Acne, disinfection of surgical wounds and/or in veterinary treatments can be treated with Poly(hexamethylenebiguanide) salts.


Poly(hexamethylenebiguanide) is also used for cleaning and disinfecting objects, surfaces or premises, including in hospitals.
Poly(hexamethylenebiguanide) is a formulation based on PHMB used as sanitizer, bactericide ( antibacterial ), antiseptic and disinfectant, widely effective against positive and negative gram bacteria with applications in surface cleaners, hand cleaners / sanitizing , close to neutral powder detergent, latex polymers, antimicrobial and dishwashing liquids and other personal care applications with microbial activity.


Poly(hexamethylenebiguanide) is used as a biocide, antibacterial, Disinfectant, and Virucidal.
At a dosage of Poly(hexamethylenebiguanide) of 1% to 2%, this can be an effective replacement for alcohol in your products as water-based disinfectant.
Poly(hexamethylenebiguanide) has been used in trials studying the treatment, prevention, and supportive care of Caries, Neoplasm, Skin Diseases, Nail Diseases, and Dental Plaque, among others.


Poly(hexamethylenebiguanide) is a polymer used as a disinfectant and antiseptic.
Poly(hexamethylenebiguanide) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).


Some products containing Poly(hexamethylenebiguanide) are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection.


Poly(hexamethylenebiguanide) also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products.
Poly(hexamethylenebiguanide) is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.


Poly(hexamethylenebiguanide) is used in the majority of formulations.
Products containing Poly(hexamethylenebiguanide) are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.


Poly(hexamethylenebiguanide) eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Poly(hexamethylenebiguanide) is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.
Poly(hexamethylenebiguanide) is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.


Poly(hexamethylenebiguanide) is used in the majority of formulations.
Poly(hexamethylenebiguanide) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.



KEY FEATURES OF POLY(HEXAMETHYLENEBIGUANIDE):
◼ Broad spectrum activity offers effective control against bacteria, yeasts and moulds
◼ Water soluble, zero VOC
◼ Retains activity in hard and soft water and in the presence of organic material
◼ Cost effective
◼ Non-foaming
◼ Low toxicity with biodegradable profile
◼ Effective pH range 2-10



PHYSICAL and CHEMICAL PROPERTIES of POLY(HEXAMETHYLENEBIGUANIDE):
CAS Number: 28757-47-3
Chemical formula: (C8H17N5)n
Molecular Formula: C8H19N5
Molecular Weight: 185.27 g/mol
IUPAC Name: 1-(diaminomethylidene)-2-hexylguanidine
Standard InChI: InChI=1S/C8H19N5/c1-2-3-4-5-6-12-8(11)13-7(9)10/h2-6H2,1H3,(H6,9,10,11,12,13)
Standard InChIKey: VAZJLPXFVQHDFB-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCN/C(=N\C(=N)N)/N
SMILES: CCCCCCN=C(N)N=C(N)N
Canonical SMILES: CCCCCCN=C(N)N=C(N)N
CBNumber: CB91074557
Molecular Formula of Hydrochloride Salt: C8H19N5.ClH
Molecular Weight of Hydrochloride Salt: 221.734
MDL Number: MFCD00242965

Chemical Name: Poly(hexamethylenebiguanide)
CAS Registry Number: 28757-47-3
PubChemID: 20977
PSA: 97.78000
LogP: 2.25570
EINECS: 923-111-4
Molecular Weight: 185.27
Density: 1.2±0.1 g/cm3
Boiling Point: 347.7±25.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.8 mmHg at 25°C
Enthalpy of Vaporization: 59.2±3.0 kJ/mol
Flash Point: 164.1±23.2 °C
Index of Refraction: 1.550

Molar Refractivity: 51.1±0.5 cm3
#H bond acceptors: 5
#H bond donors: 6
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 1
ACD/LogP: 1.36
ACD/LogD (pH 5.5): -1.17
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -1.17
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 103 Å2
Polarizability: 20.2±0.5 10-24cm3

Surface Tension: 45.7±7.0 dyne/cm
Molar Volume: 160.2±7.0 cm3
XLogP3-AA: 0.5
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 6
Exact Mass: 185.16404563
Monoisotopic Mass: 185.16404563
Topological Polar Surface Area: 103 Ų
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 181
Form: Liquid
Color: Colorless to pale yellow

Odor: Odorless
pH Value (1% Solution): 4.0 – 6.0
Melting Point, °C: Not determined
Boiling Point, °C: 102 – 105°C
Flash Point: Not applicable
Ignition Temperature, °C: Product is not self-igniting
Flammability, °C:
Lower Explosion Limit: Product is not explosive
Upper Explosion Limit: Product is not explosive
Vapor Pressure @ 20°C: 23 hPa
Density @ 20°C: 1.030 – 1.060
Solubility/Miscibility In Water: Fully miscible
Partition Coefficient: n-octanol/water: Not available
Solids Content, %: 19 – 21



FIRST AID MEASURES of POLY(HEXAMETHYLENEBIGUANIDE):
-Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes.
-Skin:
Removing contaminated clothing and shoes.
-Inhalation:
Move to fresh air.



ACCIDENTAL RELEASE MEASURES of POLY(HEXAMETHYLENEBIGUANIDE):
-Spills/Leaks:
Sweep up, then place into a suitable container for disposal.



FIRE FIGHTING MEASURES of POLY(HEXAMETHYLENEBIGUANIDE):
-General Information:
*Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.



EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(HEXAMETHYLENEBIGUANIDE):
-Personal Protective Equipment:
*Eyes:
Wear safety glasses.
*Skin:
Wear appropriate protective gloves.
*Clothing:
Wear appropriate protective clothing to minimize contact with skin.



HANDLING and STORAGE of POLY(HEXAMETHYLENEBIGUANIDE):
-Handling:
Wash after handling.
Remove contaminated clothing and wash before reuse.



STABILITY and REACTIVITY of POLY(HEXAMETHYLENEBIGUANIDE):
-Chemical Stability:
Stable under normal temperatures and pressures.
-Hazardous Polymerization:
Has not been reported.