Other Industries

NONYL PHENOL 10
POE nonyl Phenyl Ether; Ethoxylated nonylphenol; Polyoxyethylene Nonylphenyl Ether; nonylphenyl polyethyleneglycol ether, nonionic; macrogol nonylphenyl ether; Polyethylene Mono(nonylphenyl)ether Glycols; CAS NO: 26027-38-3
NONYL PHENOL 10
Nonyl phenol 10 is a non-ionic and surface-active chemical raw material.
Nonyl phenol 10 has high cleaning power.
Nonyl phenol 10 is a Nonionic surfactant.


CAS Number: 127087-87-0
EC-Number: 500-315-8
MDL number: MFCD00132411
Chemical Formula: C15H24O


Nonyl phenol 10 is an alkylphenol ethoxylates (APEO) which is widely used as non-ionic surfactants, nonylphenol ethoxylate (NPEO) and octylphenol ethoxylate being the main representatives of this group.
Nonyl phenol 10 is a Nonylphenol Ethoxylate based wetting agent and surfactant.


Nonyl phenol 10 is not ionic.
Nonyl phenol 10 has high rinseability feature.
Nonyl phenol 10 has a low odor profile.


Nonyl phenol 10 is soluble in water and chlorinated solvents and most polar solvents.
Nonyl phenol 10 is non-ionic in water, it is no charge.
Nonyl phenol 10 is chemically stable in the presence of dilute acids, bases and salts.


Nonyl phenol 10 is nonionic and provides excellent detergency, rinse-ability, and low odor.
Nonyl phenol 10 is compatible with soaps, anionic and other nonionic surfactants and many organic substances.
Nonyl phenol 10 has good solubilization and emulsification function.


Nonyl phenol 10, Surfactant is a Nonylphenol Ethoxylate based surfactant.
Non-ionic surfactant, product resulting from the condensation of Nonylphenol and Ethylene Oxide, 10 mol nonylphenol is a colorless, transparent liquid that is soluble in water.


Nonyl phenol 10 does not ionize in water, stable in acid and alkaline media, compatible with other surfactant agents of an anionic, cationic and amphoteric nature.
Nonyl phenol 10 is nonionic surfactant.


Nonylphenols are compounds in the alkylphenols chemical class.
The structure of Nonyl phenols can vary.
The nonyl group can be attached to the phenol ring at various positions, often at the 4 or 2 position;


It can be branched or linear.
Branched nonylphenol, 4-nonylphenol, is the most commonly produced and marketed nonylphenol.
Although pure Nonyl phenol 10 is colorless, the mixture of nonylphenol isomers is a light yellow liquid.


Nonylphenols are moderately soluble in water but soluble in alcohol.
Nonylphenol arises from the environmental degradation of Nonyl phenol 10s, which are metabolites of commercial detergents called alkylphenol ethoxylates.
Nonyl phenol ethoxylates are clear light orange colored liquids.


Due to these properties, Nonyl phenol 10 is used in the synthesis of detergents, cleaners, emulsifiers and various other products.
Nonyl phenol 10 is amphipathic (having both hydrophilic and hydrophobic properties), which allows them to envelop non-polar substances such as oil and grease and isolate them from water.



USES and APPLICATIONS of NONYL PHENOL 10:
Nonyl phenol 10 is an industrial agent for detergent and other cleaning materials.
Nonyl phenol 10 performs in neutral cleaners.
Nonyl phenol 10 is usually used in surface actives together with distributing and complexing agents.


Nonyl phenol 10 is important in the production of laundry detergents.
Nonyl phenol 10s main applications are; in detergents and cleaners and in industrial processes where the above properties are important.
Nonyl phenol 10 is used in the industries of textile and leather.


Nonyl phenol 10 is used in the metal industry.
Nonyl phenol 10 is used in the paper industry.
Nonyl phenol 10 is used to increase the efficiency in oil pools.


Nonyl phenol 10 is used as cleaners & detergents, degreasers, paper & textile processing, paints, prewash spotters, agrochemicals, metalworking fluids, oil field chemicals.
Nonyl phenol 10 possesses good detergency performance.


Nonyl phenol 10 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonyl phenol 10 can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.


Barium and calcium salts of Nonyl phenol 10 are also used as heat stabilizers for polyvinyl chloride (PVC).
Nonyl phenol 10 is also often used as an intermediate in the manufacture of the non-ionic surfactants nonylphenol exthoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.


Nonyl phenol 10 and nonylphenol ethoxylates are only used as components of household detergents outside of Europe.
Nonyl phenol 10, is used in many epoxy formulations mainly in North America.
Nonyl phenol 10 can be used in cleaning product formulations where an increase in surface activity is required.


Nonyl phenol 10 can be used in emulsifying applications.
Nonyl phenol 10 is used as a wetting agent and emulsifier in emulsion polymerization, drilling and production.
Nonyl phenol 10 is an emulsifier widely used for its versatility.


Nonyl phenol 10 is a non-ionic surfactant .
Nonyl phenol 10 is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.
Nonyl phenol 10 is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.


Nonyl phenol 10 is used in the manufacture of personal care products.
Nonyl phenol 10 possesses good detergency performance.
Nonyl phenol 10 has high emulsifying feature.


Nonyl phenol 10 is used as an additive in the production of pesticides.
Nonyl phenol 10 is used Papers and textiles, Paints, Agrochemicals, Dishwashing liquid, and Other household use.
Nonyl phenol 10 is also not sensitive to molten metal ions, which ensures that their concentration is not too high.


Nonyl phenol 10 for use in paints and coatings, paper and textile processing, cleaners and detergents, agrochemicals, and metalworking fluids; with excellent detergency, outstanding wetting, versatile solubility characteristics, and exceptional handling properties.
Nonyl phenol 10 is nonionic and provides excellent detergency, rinse-ability, and low odor.


Nonyl phenol 10 is used in cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, metalworking fluids.
Nonyl phenol 10, which is easily soluble in hot water, does not form any ions when dissolved in water.
In addition, Nonyl phenol 10 is a stabilizer in plastic food packaging.


Barium and calcium salts of Nonyl phenol 10 are also used as heat stabilizers for polyvinyl chloride (PVC).
Nonyl phenol 10 is used for washing and soaking all natural and synthetic fibers.
Nonyl phenol 10 can also be used in oilfield drilling and production formulations.


Nonyl phenol 10 is used as additives in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
Nonyl phenol 10 is used Excellent detergency, Outstanding wetting
Versatile solubility characteristics, soluble in water, Exceptional handling properties, Low odor, and Excellent rinseability.


Nonyl phenol 10 is used In detergent production, Antioxidants, In lubricant oil additives, In paint production, Laundry and dishwashing detergents.
In the agricultural field, Nonyl phenol 10 is used together with rosin during adhesive production, as it reduces surface tension and acts as a good wetting agent.
Nonyl phenol 10 is also often used as an intermediate in the manufacture of non-ionic surfactants nonylphenol exoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.


Nonyl phenol 10 is a non-ionic surfactant .
Nonyl phenol 10 is also works as a detergent and wetting agent.
Nonyl phenol 10 quickly removes the filth from the fibers and takes the wax and pectin from the fiber in cotton and allows it to be easily removed.


Nonyl phenol 10 Surfactant is a Nonylphenol Ethoxylate based surfactant.
Nonyl phenol 10 is also works as a detergent and wetting agent.
Nonyl phenol 10 is compatible with dyes, pigments, protective colloids, thickener and other substances with a molar mass in the further range.


Nonyl phenol 10 is used as cleaners & detergents, degreasers, paper & textile processing, paints, prewash spotters, agrochemicals, metalworking fluids, oil field chemicals.
Nonyl phenol 10 is used In insecticides, In plastic,


In emulsifiers and solubilizers, Cleaners & degreasers, and Agrochemical.
Nonyl phenol 10 is used Oil in water emulsion,Metalworking fluid, Paint & coatings, Surfactant, and Detergents.
Nonyl phenol 10 is used Cleaners & detergents, Paper & textile processing, Paints & coatings, Agro-chemicals, and Metalworking fluids.


Nonyl phenol 10 is used Nonylphenol Ethoxylate, Cleaning product formulations, Paints and coatings, Emulsion polymerization, and Anywhere there is a need for increased surface activity.
Nonyl phenol 10 is also precursors of alkylphenol ethoxylates and nonylphenol ethoxylates, which are commercially important nonionic surfactants used in detergents, paints, pesticides, personal care products and plastics.


Nonyl phenol 10 can also be used to produce tris (4-nonyl-phenyl) phosphide (TNPP), an antioxidant used to protect polymers such as rubber, vinyl polymers, polyolefins and polystyrene,
Nonyl phenol 10 is used Auxiliary for washing and finishing of wool, cotton, viscose, rayon and synthetic fiber.


Nonyl phenol 10 is used in open cotton cooking, as a wetting agent in the pre-cleaning of the fiber, in an enzyme desizing bath, and as a leveling agent in dyeing.
Nonyl phenol 10 and its ethoxylates are only used as components of household detergents.
Nonyl phenol 10 is used in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.


Nonyl phenol 10 is not affected by hard waters, acidic and basic environments.
Nonyl phenol 10 is used as an additive in formulations in many sectors, mainly shampoo and soap.
Nonyl phenol 10 tends to dissolve in both the aqueous phase and oil and reduce the surface tension of liquids.


Nonyl phenol 10 foams less compared to anion active substances.
Nonyl phenol 10 is used in cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, metalworking fluids.
In our country, Nonyl phenol 10 is used as an additive in formulations in many sectors, especially shampoo and soap.


Nonyl phenol 10 is used as a surfactant cleaner and degreaser in many industrial areas, especially detergents.
Nonyl phenol 10 is also used as an emulsifier in some productions.
Nonyl phenol 10 is used Coating Auxiliary Agents, Leather Auxiliary Agents, Paper Chemicals, Petrol.


Nonyl phenol 10 (nonyl phenol 10 moles) is used as emulsifier & detergent for textile, paint, agrochemicals, cleaners formulation.
Nonyl phenol 10 is used as a surfactant cleaner and degreaser in many industrial areas, especially detergents.
Nonyl phenol 10 is also used as an emulsifier in some productions.


In the agricultural field, Nonyl phenol 10 is used with colophon resin during the production of spreading adhesive, as it reduces the surface tension and acts as a good wetting agent.
Nonyl phenol ethoxylate types are very effective detergents, emulsifiers, wetting agents and dispersing agents.
Nonyl phenol ethoxylate types are non-ionic and chemically non-reactive.


-Applications & Uses of Nonyl phenol 10:
*Acid Cleaners
*Penetrant
*Concrete Cleaners
*Dispersant
*Dispersant
*Glass Cleaners
*Metal Cleaners
*Steam Cleaner
*Agricultural Emulsifier
*Car Wash Soap
*Dairy Cleaners
*Detergents
*Textile


-Applications & Uses of Nonyl phenol 10:
*Sanitizers
*Hard Surface Cleaners
*Oil Well Drilling Fluids
*Textile
*Alkaline Cleaner
*Cleaning Compounds
*Deinking Paper
*Degreaser
*Disinfectant Cleaners
*I & I Cleaners
*Paint & Coatings
*Solubilizing Agent


-Detergent:
Nonyl phenol 10 is used as a non-ionic surface active wetting agent or an emulsifier, depending on the additional oxide ratio and order in this sector.
Nonyl phenol 10 is also used as an additive and cleaner in dish soap, shampoo, etc. products.


-Textile:
Nonyl phenol 10 is used in the printing part of the products produced in this sector.
-Chemistry:
Nonyl phenol 10 is used as a stabilizer in the chemical industry.



BENEFITS of NONYL PHENOL 10:
*Deliver a combination of economy and performance
*Excellent detergency and wetting
*Good solubilization and emulsification
*Excellent detergency
*Outstanding wetting
*Versatile solubility characteristics
*Exceptional handling properties
*Low odor
*Excellent rinseability



USAGE of NONYL PHENOL 10:
Nonyl phenol 10 is preferably given to baths as 10-15% solutions.
Nonyl phenol 10 is used at 0.2-0.7 g/lt ratios in different applications, bathrooms, depending on operating conditions.
Nonyl phenol 10 is recommended to use 0.5-2 g/lt Geosol Nonyl phenol 10 together with 5 g/lt sodium sulfate for wool washing.
0.5-2 g/lt Geosol Nonyl phenol 10 and 3-5 g/lt soda are used for wool washing in alkaline environments.



FUNCTIONS of NONYL PHENOL 10:
*Cleaner & Degreaser
*Emulsifier
*Surfactant



PRODUCTION and REACTIONS of NONYL PHENOL 10:
Nonyl phenol 10 is produced by printing on elastic fabric with certain thinners as a viscosity reducer.
Nonyl phenol 10 is effective in creating a sim effect.
Also, a gilding effect is created thanks to this substance.



PHYSICAL and CHEMICAL PROPERTIES of NONYL PHENOL 10:
Appearance at 25ºC: Clear to Viscous Liquid
Acid value mg KOH/gm max: 1
Active content %: 99.5
Color apha: 50
Cloud point ºC: 56-60
Hydroxyl value mg KOH/gm: 85-90
% Moisture content by KF: 0.5
Nature: Nonionic
pH: 6-8
Appearance Form: liquid
Color: yellow
Odor: mild
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Freezing point: 3,8 °C
Initial boiling point and boiling range: > 250 °C
Flash point: 247 °C - closed cup - ASTM D 93
Evaporation rate: No data available
Flammability (solid, gas): No data available

Upper/lower flammability or explosive limits: No data available
Vapor pressure: < 0,01 hPa at 20 °C
Vapor density: No data available
Density: No data available
Relative density: No data available
Water solubility: completely soluble
Partition coefficient: n-octanol/water
log Pow: 2,1 - 3,4
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: 237 mm2/s at 25 °C
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Solubility in Water: Soluble (; insoluble in kerosene, xylene soluble in methanol)
Ph: 6.3 (10% sol.)
Viscosity (EBM): C 25 240
Flash point: 94 °C
Molecular formula: C9H19C6H4 ( OCH2CH2) NOH
Melting point: 1 °C
Specific gravity: 1.06

Appearance: liquid
Boiling Point: > 250 °C (> 482 °F)
Color: yellow
Density: 1.06 g/cm3 @ 20 - 25 °C (68 - 77 °F)
Flash Point: 197 °C (387 °F)
Kinematic Viscosity: 237 mm2/s @ 25 °C (77 °F)
Melting Point: 6.1 - 7.8 °C (43.0 - 46.0 °F)
Odor: mild
Partition Coefficient Pow: 2.1 - 3.4
pH: 7 @ 20 - 25 °C (68 - 77 °F)
Relative Density: 1.0622 @ 20 °C (68 °F) Reference Material: (water = 1)
Relative Vapor Density: > 1 @ 20 - 25 °C (68 - 77 °F)
Solubility in Water: completely soluble
Vapor Pressure: < 0.01 mmHg @ 20 °C (68 °F)
Molecular Weight: 199.16406g/mol
Molecular Formula: C7H9N3O4
Compound Is Canonicalized: True
XLogP3-AA: _0.7
Exact Mass: 199.05930578

Monoisotopic Mass: 199.05930578
Complexity: 240
Rotatable Bond Count: 3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Topological Polar Surface Area: 114
Heavy Atom Count: 14
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
Appearance: It is a clear viscous liquid.
Chemical structure: It is an alkyl phenol based, nonionic emulsifier system.
Ionic Character: nonionic



FIRST AID MEASURES of NONYL PHENOL 10:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NONYL PHENOL 10:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of NONYL PHENOL 10:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NONYL PHENOL 10:
-Control parameters:
Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use safety glasses.
*Body Protection:
Protective clothing.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NONYL PHENOL 10:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of NONYL PHENOL 10:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available



SYNONYMS:
NONYL PHENOL 10EO
Nonylphenol 10EO
2-(p-Nonylphenoxy)ethanol
Nonoxinol
NONOXYNOL
2-(4-nonylphenoxy)ethanol
Nonoxynols
104-35-8
Nonoxynol-7
Nonoxynol 10
nonylphenol ethoxylate
Conceptrol
Egyptol
Intercept
Pannox 111
Pannox 116
Amway APSA 80
Bion NE 9
Iconol NP 100
Monopol NP 1013
Monopol NP 1060
Hyoxyd X 100
Hyoxyd X 200
Hyoxyd X 400
Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy
Emulgen 911
Emulgin 913
Nonylphenoxypolyethoxyethanols
127087-87-0
Nonoxinol [INN]
Delfen (TN)
Nonoxynol 9 (USP)
616.82 average
Nonoxynol 9 [USAN]
OSD2GAP7HY
UNII-OSD2GAP7HY
NONOXINOL 15
NONOXINOL 30
11096-42-7
PEG-2 Nonyl phenyl ether
UNII-1F75BOT2DZ
UNII-60ZT1XYO5N
Nonoxynol 4 [USAN]
Nonoxynol 15 [USAN]
Nonoxynol 30 [USAN]
Ethoxylated p-nonyl phenol
p-Nonylphenol, ethoxylated
PEG-7 Nonyl phenyl ether
NOP 8
PEG-14 Nonyl phenyl ether
PEG-18 Nonyl phenyl ether
PEG-50 Nonyl phenyl ether
2-(4-Nonylphenoxy) ethanol
Koromex
Semicid
Emko
Ethanol, 2-(4-nonylphenoxy)-
Encare oval
Today Sponge
Ortho-Creme
Nonoxynol 4
Nonoxynol 6
Liponox NCY
Gynol II
Nonyl Phenol On Ethoxy Silate
Cremophor NP 14
Imbetin N 7A
Nonoxynol 8.5
4-Nonyl Phenol Monoethoxylate
Emulan 30
Emulan 40
K-Y Plus
NP-9
APSA 80
4-Nonylphenol decaglycol ether
Polyethylene glycol 100 nonyl phenyl ether
Polyoxyethylated-p-nonyl phenol
NOP 17
Polyoxyethylene nonylphenyl ether
HSDB 7217
Amway All Purpose Spray Adjuvant
p-Nonylphenyl polyoxyethylene ether
Nonylphenoxypoly(ethyleneoxy)ethanol
NP 8.5
Decaethylene glycol p-nonylphenyl ether
p-Nonylphenol decaethylene glycol ether
Polyoxyethylene (7) nonyl phenyl ether
p-Nonylphenol-polyethylene glycol adduct
Polyoxyethylene (14) nonyl phenyl ether
Polyoxyethylene (18) nonyl phenyl ether
Polyoxyethylene (50) nonyl phenyl ether
Nonoxynol 4 (USAN)
Akyporox NP 150
Newcol 565
Pannox 110
Advantage 24
Nonoxynol 13
Nonoxynol 14
Nonoxynol 15
Nonoxynol 30
Nonoxynol-14
Nonoxynol-18
Nonoxynol-50
UNII-8869L92EOT
UNII-E9AU396Z19
UNII-K7O76887AP
UNII-KND68343W4
UNII-M693M091RR
4867M0AEJI
CCRIS 8448
ED8J5T817W
JJX07DG188
CHEMBL1797943
DTXSID4058601
UNII-A906T4D368
UNII-BK168521Q8
(oxyeth-ylene) nonylphenyl ether
CHEBI:53774
CTK5H8961
KUXGUCNZFCVULO-UHFFFAOYSA-N
Cremophor NP 10
Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-
Polyethylene glycol (7) nonyl phenyl ether
Nonoxynol 15 (USAN)
Nonoxynol 30 (USAN)
Decaethylene glycol mono(p-nonylphenyl) ether
N 100
Polyethylene glycol (14) nonyl phenyl ether
Polyethylene glycol (18) nonyl phenyl ether
Polyethylene glycol (50) nonyl phenyl ether
Polyethylene glycol mono(p-nonylphenyl) ether
Glycols, polyethylene, mono(p-nonylphenyl) ether
alpha-(p-Nonylphenyl)-omega-hydroxydeca(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxynona(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxypoly(oxyethylene)
Phenol, p-nonyl-, monoether with polyethylene glycol
alpha-(p-Nonylphenyl)-omega-hydroxytetra(oxyethylene)
4-n-Nonylphenol-mono-ethoxylate
alpha-(p-Nonylphenyl)-omega-hydroxypentadeca(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxytriaconta(oxyethylene)
Nonoxinols
C18H30O2
BK168521Q8
Polyoxyethylene (2) nonyl phenyl ether
96827-63-3
LS-72940
FT-0673037
X7302
Polyethylene glycol mono(4-nonylphenyl) ether
D06490
alpha-(4-nonylphenyl)-omega-hydroxypoly(oxyethylene)
J-001157
4-Nonylphenol-mono-ethoxylate 10 microg/mL in Acetone
4-Nonylphenol-mono-ethoxylate 10 microg/mL in Methanol
1-(2-Hydroxyethyl)-5-nitro-1H-pyrrole-2-carboxamide
UNII-HR8408HWGL
1F75BOT2DZ
60ZT1XYO5N
HR8408HWGL
Nonoxynol 9 [USAN:USP]
UNII-4867M0AEJI
UNII-ED8J5T817W
UNII-JJX07DG188
nonylphenoxy polyethoxy ethanol
SCHEMBL198140
UNII-3X709X44TE
UNII-48Q180SH9T
UNII-5V4827GL2O
UNII-6FW840C8W9
UNII-6NR43D77O6
Np-10
Np-10 (Nonylphenol ethoxylate)
1-(2-hydroxyethyl)-5-nitropyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide, 1-(2-hydroxyethyl)-5-nitro-
1-(2-Hydroxyethyl)-2-carbamoyl-5-nitropyrrol
1-(2-Hydroxyethyl)-5-nitro-1H-pyrrole-2-carboxamide
1-(2-hydroxyethyl)-5-nitropyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide, 1-(2-hydroxyethyl)-5-nitro-
NP 10
NP 10 (Pharmaceutical)
Np-10 (Nonylphenol ethoxylate)
Pyrrole-2-carboxamide,1-(2-hydroxyethyl)-5-nitro
3X709X44TE
48Q180SH9T
5V4827GL2O
6FW840C8W9
6NR43D77O6
8869L92EOT
E9AU396Z19
K7O76887AP
KND68343W4
M693M091RR
KS-000014UE
ZINC1850508
C33H60O10
AKOS026749958
A906T4D368


NONYL PHENOL 10 EO
Nonyl Phenol 10 EO has excellent detergency, outstanding wetting, good rinseability, and versatile solubility characteristics.
Nonyl Phenol 10 EO is a nonionic surfactant.
Nonyl Phenol 10 EO has good solubilization and emulsification function.


CAS Number: 127087-87-0
EC-Number: 500-315-8
MDL number: MFCD00132411
Chemical Formula: C15H24O


Nonyl Phenol 10 EO is not ionic.
Nonyl Phenol 10 EO is an alkylphenol ethoxylates (APEO) which is widely used as non-ionic surfactants, nonylphenol ethoxylate (NPEO) and octylphenol ethoxylate being the main representatives of this group.


Nonyl Phenol 10 EO has good solubilization and emulsification function.
Although pure Nonyl Phenol 10 EO is colorless, the mixture of nonylphenol isomers is a light yellow liquid.
Nonyl Phenol 10 EO is amphipathic (having both hydrophilic and hydrophobic properties), which allows them to envelop non-polar substances such as oil and grease and isolate them from water.


Non-ionic surfactant, product resulting from the condensation of Nonylphenol and Ethylene Oxide, 10 mol nonylphenol is a colorless, transparent liquid that is soluble in water.
Nonyl Phenol 10 EO is nonionic surfactant.


Nonyl Phenol 10 EO is chemically stable in the presence of dilute acids, bases and salts.
Due to these properties, Nonyl Phenol 10 EO is used in the synthesis of detergents, cleaners, emulsifiers and various other products.
Nonyl Phenol 10 EO has high rinseability feature.


Nonyl Phenol 10 EO has a low odor profile.
Nonyl Phenol 10 EO is compatible with soaps, anionic and other nonionic surfactants and many organic substances.
Nonyl Phenol 10 EO is a non-ionic and surface-active chemical raw material.


Nonyl Phenol 10 EO has high cleaning power.
Nonyl phenol ethoxylates are clear light orange colored liquids.
Nonylphenols are moderately soluble in water but soluble in alcohol.


Nonyl Phenol 10 EO does not ionize in water, stable in acid and alkaline media, compatible with other surfactant agents of an anionic, cationic and amphoteric nature.
Nonyl Phenol 10 EO is nonionic and provides excellent detergency, rinse-ability, and low odor.
Nonyl Phenol 10 EO is a Nonylphenol Ethoxylate based wetting agent and surfactant.


Nonyl Phenol 10 EO, Surfactant is a Nonylphenol Ethoxylate based surfactant.
Nonyl Phenol 10 EO is soluble in water and chlorinated solvents and most polar solvents.
Nonyl Phenol 10 EO is non-ionic in water, it is no charge.
Nonylphenol arises from the environmental degradation of Nonyl Phenol 10 EOs, which are metabolites of commercial detergents called alkylphenol ethoxylates.


Nonylphenols are compounds in the alkylphenols chemical class.
The structure of Nonyl phenols can vary.
The nonyl group can be attached to the phenol ring at various positions, often at the 4 or 2 position;


It can be branched or linear.
Branched nonylphenol, 4-nonylphenol, is the most commonly produced and marketed nonylphenol.
Nonylphenols are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.


Nonylphenols can come in numerous structures, all of which may be considered alkylphenols.
They are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
They are used extensively in epoxy formulation in North America but its use has been phased out in Europe.


These compounds are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonylphenol has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.



USES and APPLICATIONS of NONYL PHENOL 10 EO:
Uses of Nonyl phenol 10: Cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, metalworking fluids.
Nonyl Phenol 10 EO is used in cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, metalworking fluids.
Nonyl Phenol 10 EO performs in neutral cleaners.


Nonyl Phenol 10 EO is used as cleaners & detergents, degreasers, paper & textile processing, paints, prewash spotters, agrochemicals, metalworking fluids, oil field chemicals.
Nonyl Phenol 10 EO is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.


Nonyl Phenol 10 EO for use in paints and coatings, paper and textile processing, cleaners and detergents, agrochemicals, and metalworking fluids; with excellent detergency, outstanding wetting, versatile solubility characteristics, and exceptional handling properties.
Nonyl Phenol 10 EO can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.


Barium and calcium salts of nonylphenol are also used as heat stabilizers for polyvinyl chloride (PVC).
Nonyl Phenol 10 EO is used in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
Nonyl Phenol 10 EO is also often used an intermediate in the manufacture of the non-ionic surfactants nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.


Nonyl Phenol 10 EO is used for washing and soaking all natural and synthetic fibers.
Nonyl Phenol 10 EO can also be used in oilfield drilling and production formulations.
Nonyl Phenol 10 EO is also often used as an intermediate in the manufacture of non-ionic surfactants nonylphenol exoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.


Nonyl Phenol 10 EO and nonylphenol ethoxylates are only used as components of household detergents outside of Europe.
Nonyl Phenol 10 EO can be used in cleaning product formulations where an increase in surface activity is required.
Nonyl Phenol 10 EO is used in many epoxy formulations mainly in North America.


Barium and calcium salts of Nonyl Phenol 10 EO are also used as heat stabilizers for polyvinyl chloride (PVC).
Nonyl Phenol 10 EO is also precursors of alkylphenol ethoxylates and nonylphenol ethoxylates, which are commercially important nonionic surfactants used in detergents, paints, pesticides, personal care products and plastics.


Nonyl Phenol 10 EO is compatible with dyes, pigments, protective colloids, thickener and other substances with a molar mass in the further range.
Nonyl Phenol 10 EO possesses good detergency performance.
Nonyl Phenol 10 EO has high emulsifying feature.


Nonyl Phenol 10 EO is used as a surfactant cleaner and degreaser in many industrial areas, especially detergents.
Nonyl Phenol 10 EO quickly removes the filth from the fibers and takes the wax and pectin from the fiber in cotton and allows it to be easily removed.
Nonyl Phenol 10 EO is used Cleaners & detergents, Paper & textile processing, Paints & coatings, Agro-chemicals, and Metalworking fluids.


Nonyl Phenol 10 EO is used as an additive in formulations in many sectors, especially shampoo and soap.
Nonyl Phenol 10 EO is used as an additive in formulations in many sectors, mainly shampoo and soap.
Nonyl Phenol 10 EO is used Auxiliary for washing and finishing of wool, cotton, viscose, rayon and synthetic fiber.


Nonyl Phenol 10 EO is used Nonylphenol Ethoxylate, Cleaning product formulations, Paints and coatings, Emulsion polymerization, and Anywhere there is a need for increased surface activity.
Nonyl phenol ethoxylate types are non-ionic and chemically non-reactive.


Nonyl Phenol 10 EO is also used as an emulsifier in some productions.
Nonyl Phenol 10 EO is usually used in surface actives together with distributing and complexing agents.
Nonyl Phenol 10 EO possesses good detergency performance.


Nonyl Phenol 10 EO can also be used to produce tris (4-nonyl-phenyl) phosphide (TNPP), an antioxidant used to protect polymers such as rubber, vinyl polymers, polyolefins and polystyrene.
Nonyl Phenol 10 EO is also often used as an intermediate in the manufacture of the non-ionic surfactants nonylphenol exthoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.


Nonyl Phenol 10 EO is an emulsifier widely used for its versatility.
Nonyl Phenol 10 EO is used in the manufacture of personal care products.
Nonyl Phenol 10 EO is nonionic and provides excellent detergency, rinse-ability, and low odor.


Nonyl Phenol 10 EO is used as additives in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
Nonyl Phenol 10 EO is a non-ionic surfactant .
Nonyl Phenol 10 EO is used in insecticides, In plastic, in emulsifiers and solubilizers, Cleaners & degreasers, and Agrochemical.


Nonyl Phenol 10 EO is used versatile solubility characteristics, soluble in water, Exceptional handling properties, Low odor, and Excellent rinseability.
Nonyl Phenol 10 EO is used in cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, metalworking fluids.
Nonyl Phenol 10 EO, which is easily soluble in hot water, does not form any ions when dissolved in water.


Nonyl Phenol 10 EO is used as cleaners & detergents, degreasers, paper & textile processing, paints, prewash spotters, agrochemicals, metalworking fluids, oil field chemicals.
Nonyl Phenol 10 EO foams less compared to anion active substances.


Nonyl Phenol 10 EO is used in open cotton cooking, as a wetting agent in the pre-cleaning of the fiber, in an enzyme desizing bath, and as a leveling agent in dyeing.
Nonyl Phenol 10 EO is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.
Nonyl Phenol 10 EO is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.


Nonyl Phenol 10 EO is important in the production of laundry detergents.
Nonyl Phenol 10 EO is used to increase the efficiency in oil pools.
Nonyl Phenol 10 EO can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.


Nonyl Phenol 10 EO can be used in emulsifying applications.
Nonyl Phenol 10 EO is used as an additive in the production of pesticides.
Nonyl Phenol 10 EO is used Excellent detergency, Outstanding wetting.


Nonyl Phenol 10 EO is also used as an emulsifier in some productions.
Nonyl phenol ethoxylate types are very effective detergents, emulsifiers, wetting agents and dispersing agents.
Nonyl Phenol 10 EO is also works as a detergent and wetting agent.


Nonyl Phenol 10 EO is used Oil in water emulsion, Metalworking fluid, Paint & coatings, Surfactant, and Detergents.
Nonyl Phenol 10 EO is an industrial agent for detergent and other cleaning materials.
Nonyl Phenol 10 EOs main applications are; in detergents and cleaners and in industrial processes where the above properties are important.


Nonyl Phenol 10 EO is used in the industries of textile and leather.
Nonyl Phenol 10 EO is used in the metal industry.
Nonyl Phenol 10 EO is used in the paper industry.


Nonyl Phenol 10 EO is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonyl Phenol 10 EO and nonylphenol ethoxylates are only used as components of household detergents outside of Europe.
Nonyl Phenol 10 EO, is used in many epoxy formulations mainly in North America.


Nonyl Phenol 10 EO is used as a wetting agent and emulsifier in emulsion polymerization, drilling and production.
Nonyl Phenol 10 EO is a non-ionic surfactant .
Nonyl Phenol 10 EO is used Papers and textiles, Paints, Agrochemicals, Dishwashing liquid, and Other household use.


Nonyl Phenol 10 EO is also not sensitive to molten metal ions, which ensures that their concentration is not too high.
In addition, Nonyl Phenol 10 EO is a stabilizer in plastic food packaging.
Nonyl Phenol 10 EO is used In detergent production, Antioxidants, In lubricant oil additives, In paint production, Laundry and dishwashing detergents.


In the agricultural field, Nonyl Phenol 10 EO is used together with rosin during adhesive production, as it reduces surface tension and acts as a good wetting agent.
Nonyl Phenol 10 EO is also works as a detergent and wetting agent.
Nonyl Phenol 10 EO Surfactant is a Nonylphenol Ethoxylate based surfactant.


Nonyl Phenol 10 EO and its ethoxylates are only used as components of household detergents.
Nonyl Phenol 10 EO is not affected by hard waters, acidic and basic environments.
Nonyl Phenol 10 EO tends to dissolve in both the aqueous phase and oil and reduce the surface tension of liquids.


Nonyl Phenol 10 EO is used as a surfactant cleaner and degreaser in many industrial areas, especially detergents.
Nonyl Phenol 10 EO is used Coating Auxiliary Agents, Leather Auxiliary Agents, Paper Chemicals, Petrol.


Nonyl Phenol 10 EO (Nonyl Phenol 10 EO moles) is used as emulsifier & detergent for textile, paint, agrochemicals, cleaners formulation.
In the agricultural field, Nonyl Phenol 10 EO is used with colophon resin during the production of spreading adhesive, as it reduces the surface tension and acts as a good wetting agent.


-Applications of Nonyl phenol 10:
Nonyl phenol 10 is suitable for use in applications such as:
• Cleaners & detergents
• Paper & textile processing
• Laundry
• Paints & coatings
• Dust control
• Agrochemicals
• Metalworking fluids


-Textile:
Nonyl Phenol 10 EO is used in the printing part of the products produced in this sector.
-Chemistry:
Nonyl Phenol 10 EO is used as a stabilizer in the chemical industry.


-Applications & Uses of Nonyl Phenol 10 EO:
*Sanitizers
*Hard Surface Cleaners
*Oil Well Drilling Fluids
*Textile
*Alkaline Cleaner
*Cleaning Compounds


-Detergent:
Nonyl Phenol 10 EO is used as a non-ionic surface active wetting agent or an emulsifier, depending on the additional oxide ratio and order in this sector.
Nonyl Phenol 10 EO is also used as an additive and cleaner in dish soap, shampoo, etc. products.


-Applications & Uses of Nonyl Phenol 10 EO:
*Deinking Paper
*Degreaser
*Disinfectant Cleaners
*I & I Cleaners
*Paint & Coatings
*Solubilizing Agent


-Applications & Uses of Nonyl Phenol 10 EO:
*Acid Cleaners
*Penetrant
*Concrete Cleaners
*Dispersant
*Dispersant
*Glass Cleaners
*Metal Cleaners


-Applications & Uses of Nonyl Phenol 10 EO:
*Steam Cleaner
*Agricultural Emulsifier
*Car Wash Soap
*Dairy Cleaners
*Detergents
*Textile



USAGE of NONYL PHENOL 10 EO:
Nonyl phenol 10 is preferably given to baths as 10-15% solutions.
Nonyl phenol 10 is used at 0.2-0.7 g/lt ratios in different applications, bathrooms, depending on operating conditions.
Nonyl phenol 10 is recommended to use 0.5-2 g/lt Geosol Nonyl phenol 10 together with 5 g/lt sodium sulfate for wool washing.
0.5-2 g/lt Geosol Nonyl phenol 10 and 3-5 g/lt soda are used for wool washing in alkaline environments.



BENEFITS of NONYL PHENOL 10 EO:
*Deliver a combination of economy and performance
*Excellent detergency and wetting
*Good solubilization and emulsification
*Excellent detergency
*Outstanding wetting
*Versatile solubility characteristics
*Exceptional handling properties
*Low odor
*Excellent rinseability



PRODUCTION and REACTIONS of NONYL PHENOL 10 EO:
Nonyl phenol 10 is produced by printing on elastic fabric with certain thinners as a viscosity reducer.
Nonyl phenol 10 is effective in creating a sim effect.
Also, a gilding effect is created thanks to this substance.



FUNCTIONS of NONYL PHENOL 10 EO:
*Cleaner & Degreaser
*Emulsifier
*Surfactant



STRUCTURE AND BASIC PROPERTIES OF NONYL PHENOL 10 EO:
Nonylphenols fall into the general chemical category of alkylphenols.
The structure of NPs may vary.
The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear.
Branched nonylphenol, 4-nonylphenol, is the most widely produced and marketed nonylphenol.
The mixture of nonylphenol isomers is a pale yellow liquid, although the pure compounds are colorless.
The nonylphenols are moderately soluble in water but soluble in alcohol.
Nonylphenol arises from the environmental degradation of nonylphenol ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylated.
NPEs are a clear to light orange color liquid.
Nonylphenol ethoxylates are nonionic in water, which means that they have no charge.
Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications.
They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.



PRODUCTION OF NONYL PHENOL 10 EO:
Nonylphenol can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates. Industrially, nonylphenols are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes.
This synthesis leads to a very complex mixture with diverse nonylphenols.
Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.
To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.
Since its discovery in 1940, nonylphenol production has increased exponentially, and between 100 and 500 million pounds of nonylphenol are produced globally every year, meeting the definition of High Production Volume Chemicals.
Nonylphenols are also produced naturally in the environment.
One organism, the velvet worm, produces nonylphenol as a component of its defensive slime.
The nonylphenol coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted.
It also prolongs the drying process long enough for the slime to reach its target.



PHYSICAL and CHEMICAL PROPERTIES of NONYL PHENOL 10 EO:
Appearance at 25ºC: Clear to Viscous Liquid
Acid value mg KOH/gm max: 1
Active content %: 99.5
Color apha: 50
Cloud point ºC: 56-60
Hydroxyl value mg KOH/gm: 85-90
% Moisture content by KF: 0.5
Nature: Nonionic
pH: 6-8
Appearance Form: liquid
Color: yellow
Odor: mild
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Freezing point: 3,8 °C
Initial boiling point and boiling range: > 250 °C
Flash point: 247 °C - closed cup - ASTM D 93
Evaporation rate: No data available
Flammability (solid, gas): No data available

Appearance: liquid
Boiling Point: > 250 °C (> 482 °F)
Color: yellow
Density: 1.06 g/cm3 @ 20 - 25 °C (68 - 77 °F)
Flash Point: 197 °C (387 °F)
Kinematic Viscosity: 237 mm2/s @ 25 °C (77 °F)
Melting Point: 6.1 - 7.8 °C (43.0 - 46.0 °F)
Odor: mild
Partition Coefficient Pow: 2.1 - 3.4
pH: 7 @ 20 - 25 °C (68 - 77 °F)
Relative Density: 1.0622 @ 20 °C (68 °F) Reference Material: (water = 1)
Relative Vapor Density: > 1 @ 20 - 25 °C (68 - 77 °F)
Solubility in Water: completely soluble
Vapor Pressure: < 0.01 mmHg @ 20 °C (68 °F)
Molecular Weight: 199.16406g/mol
Molecular Formula: C7H9N3O4
Compound Is Canonicalized: True
XLogP3-AA: _0.7
Exact Mass: 199.05930578

Upper/lower flammability or explosive limits: No data available
Vapor pressure: < 0,01 hPa at 20 °C
Vapor density: No data available
Density: No data available
Relative density: No data available
Water solubility: completely soluble
Partition coefficient: n-octanol/water
log Pow: 2,1 - 3,4
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: 237 mm2/s at 25 °C
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Solubility in Water: Soluble (; insoluble in kerosene, xylene soluble in methanol)
Ph: 6.3 (10% sol.)
Viscosity (EBM): C 25 240
Flash point: 94 °C
Molecular formula: C9H19C6H4 ( OCH2CH2) NOH
Melting point: 1 °C
Specific gravity: 1.06

Monoisotopic Mass: 199.05930578
Complexity: 240
Rotatable Bond Count: 3
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Topological Polar Surface Area: 114
Heavy Atom Count: 14
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
Appearance: It is a clear viscous liquid.
Chemical structure: It is an alkyl phenol based, nonionic emulsifier system.
Ionic Character: nonionic



FIRST AID MEASURES of NONYL PHENOL 10 EO:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NONYL PHENOL 10 EO:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of NONYL PHENOL 10 EO:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NONYL PHENOL 10 EO:
-Control parameters:
Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use safety glasses.
*Body Protection:
Protective clothing.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NONYL PHENOL 10 EO:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of NONYL PHENOL 10 EO:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available



SYNONYMS:
Pannox 110
NP 10 (Pharmaceutical)
Np-10 (Nonylphenol ethoxylate)
Pyrrole-2-carboxamide,1-(2-hydroxyethyl)-5-nitro
3X709X44TE
48Q180SH9T
5V4827GL2O
6FW840C8W9
6NR43D77O6
8869L92EOT
E9AU396Z19
K7O76887AP
KND68343W4
M693M091RR
KS-000014UE
ZINC1850508
C33H60O10
AKOS026749958
A906T4D368
Advantage 24
Nonoxynol 13
Nonoxynol 14
Nonoxynol 15
Nonoxynol 30
Nonoxynol-14
Nonoxynol-18
Nonoxynol-50
UNII-8869L92EOT
UNII-E9AU396Z19
UNII-K7O76887AP
UNII-KND68343W4
UNII-M693M091RR
4867M0AEJI
CCRIS 8448
ED8J5T817W
N 100
Polyethylene glycol (14) nonyl phenyl ether
Polyethylene glycol (18) nonyl phenyl ether
Polyethylene glycol (50) nonyl phenyl ether
Polyethylene glycol mono(p-nonylphenyl) ether
Glycols, polyethylene, mono(p-nonylphenyl) ether
alpha-(p-Nonylphenyl)-omega-hydroxydeca(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxynona(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxypoly(oxyethylene)
Phenol, p-nonyl-, monoether with polyethylene glycol
alpha-(p-Nonylphenyl)-omega-hydroxytetra(oxyethylene)
4-n-Nonylphenol-mono-ethoxylate
alpha-(p-Nonylphenyl)-omega-hydroxypentadeca(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxytriaconta(oxyethylene)
Nonoxinols
C18H30O2
JJX07DG188
CHEMBL1797943
DTXSID4058601
UNII-A906T4D368
UNII-BK168521Q8
(oxyeth-ylene) nonylphenyl ether
CHEBI:53774
CTK5H8961
Nonoxynol 9 [USAN:USP]
UNII-4867M0AEJI
UNII-ED8J5T817W
UNII-JJX07DG188
Cremophor NP 10
Nonoxynol 8.5
4-Nonyl Phenol Monoethoxylate
Emulan 30
Emulan 40
K-Y Plus
NP-9
APSA 80
4-Nonylphenol decaglycol ether
Polyethylene glycol 100 nonyl phenyl ether
Polyoxyethylated-p-nonyl phenol
NOP 17
Polyoxyethylene nonylphenyl ether
HSDB 7217
Amway All Purpose Spray Adjuvant
p-Nonylphenyl polyoxyethylene ether
Nonylphenoxypoly(ethyleneoxy)ethanol
NP 8.5
Decaethylene glycol p-nonylphenyl ether
p-Nonylphenol decaethylene glycol ether
Polyoxyethylene (7) nonyl phenyl ether
p-Nonylphenol-polyethylene glycol adduct
Polyoxyethylene (14) nonyl phenyl ether
Polyoxyethylene (18) nonyl phenyl ether
Polyoxyethylene (50) nonyl phenyl ether
Nonoxynol 4 (USAN)
Akyporox NP 150
Newcol 565
KUXGUCNZFCVULO-UHFFFAOYSA-N
Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-
Polyethylene glycol (7) nonyl phenyl ether
Nonoxynol 15 (USAN)
Nonoxynol 30 (USAN)
Decaethylene glycol mono(p-nonylphenyl) ether
nonylphenoxy polyethoxy ethanol
SCHEMBL198140
UNII-3X709X44TE
UNII-48Q180SH9T
UNII-5V4827GL2O
UNII-6FW840C8W9
UNII-6NR43D77O6
Np-10
BK168521Q8
Polyoxyethylene (2) nonyl phenyl ether
96827-63-3
LS-72940
FT-0673037
X7302
Polyethylene glycol mono(4-nonylphenyl) ether
D06490
alpha-(4-nonylphenyl)-omega-hydroxypoly(oxyethylene)
J-001157
4-Nonylphenol-mono-ethoxylate 10 microg/mL in Acetone
4-Nonylphenol-mono-ethoxylate 10 microg/mL in Methanol
1-(2-Hydroxyethyl)-5-nitro-1H-pyrrole-2-carboxamide
UNII-HR8408HWGL
1F75BOT2DZ
60ZT1XYO5N
HR8408HWGL
Np-10 (Nonylphenol ethoxylate)
1-(2-hydroxyethyl)-5-nitropyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide, 1-(2-hydroxyethyl)-5-nitro-
1-(2-Hydroxyethyl)-2-carbamoyl-5-nitropyrrol
1-(2-Hydroxyethyl)-5-nitro-1H-pyrrole-2-carboxamide
1-(2-hydroxyethyl)-5-nitropyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide, 1-(2-hydroxyethyl)-5-nitro-
NP 10
UNII-OSD2GAP7HY
NONOXINOL 15
NONOXINOL 30
11096-42-7
PEG-2 Nonyl phenyl ether
UNII-1F75BOT2DZ
UNII-60ZT1XYO5N
Nonoxynol 4 [USAN]
Nonoxynol 15 [USAN]
Nonoxynol 30 [USAN]
Ethoxylated p-nonyl phenol
p-Nonylphenol, ethoxylated
PEG-7 Nonyl phenyl ether
NOP 8
PEG-14 Nonyl phenyl ether
PEG-18 Nonyl phenyl ether
PEG-50 Nonyl phenyl ether
2-(4-Nonylphenoxy) ethanol
Koromex
Semicid
Nonoxynols
104-35-8
Nonoxynol-7
Nonoxynol 10
nonylphenol ethoxylate
Conceptrol
Egyptol
Intercept
Pannox 111
Pannox 116
Amway APSA 80
Bion NE 9
Iconol NP 100
Monopol NP 1013
Monopol NP 1060
Hyoxyd X 100
Hyoxyd X 200
Hyoxyd X 400
Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy
Emulgen 911
Emulgin 913
Nonylphenoxypolyethoxyethanols
127087-87-0
Nonoxinol [INN]
Delfen (TN)
Nonoxynol 9 (USP)
616.82 average
Nonoxynol 9 [USAN]
OSD2GAP7HY
Emko
Ethanol, 2-(4-nonylphenoxy)-
Encare oval
Today Sponge
Ortho-Creme
Nonoxynol 4
Nonoxynol 6
Liponox NCY
Gynol II
Nonyl Phenol On Ethoxy Silate
Cremophor NP 14
Imbetin N 7A
NONYL PHENOL 10EO
Nonylphenol 10EO
2-(p-Nonylphenoxy)ethanol
Nonoxinol
NONOXYNOL
2-(4-nonylphenoxy)ethanol
Nonylphenol, ethoxylated
Nonyl Phenol Ethoxylate 13 Eo
Adekatol Np
Nonyl Phenol Teric N8
Nonyl Phenol Pure 40 (40 EO)
Ethoxylated nonylphenol (NP 4)
Nonyl Phenol 4 Eo
Glycols, polyethylene, mono(nonylphenyl) ether
Nonyl Phenol Ethoxylate 100 EO
Nonylphenol Ethoxylate 8 Mol
2-(Nonylphenyl)-.omega.-hydroxypoly(oxy-1,2-ethanediyl)
Nonyl Phenol Ethoxylate 12 Eo
Sinopol 908-S7 (40 EO)
Nonyl phenol, Pure 4
POLY(OXY-1,2-ETHANEDIYL),ALPHA.-(NONYLPHENYL)-.OMEGA.-HYDROXY-
Glycols, polyethylene, mono (nonylphenyl) ether
Nonyl Phenol 10 Eo
Ethoxylated Nonylphenol
Polyoxyethylene Nonylphenyl Ether
Nonyl phenol, NP5
Polyethylene glycol, nonylphenyl either
Ethoylated nonylphenol
POLY(OXY-1,2-ETHANEDIYL),.alpha.-(NONYLPHENYL)-.omega.-HYDROXY-
Surfactant Nonyl Phenol 5 Eo
Polyethylene glycol, nonylphenyl ether
Nonyl Phenol 9.5 moles EO
Nonylphenol, ethoxylated (4-EO)
Nonyl Phenol Pure 100
Nonyl Phenol Ethoxylate 2 Eo
Nonoxynol
Nonyl Phenol Tech 10
Nonyl Phenol 13 Eo
Polyethylene glycol, nonphenyl ether
Nonyl Phenol Pure 9
Peg-40 Nonyl Phenyl Ether
Nonyl Phenol Ethoxylate 7 Eo
Nonyl Phenol Ethoxylate 11 EO
Nonyl Phenol Ethoxylate 9 Mol
POLY(OXY- 1,2,-ETHANEDIYL),. alpha.-(NONYLPHENYL)-.omega.-HYDROXY-
Polyoxyethylene, nonylphenol ether
Nonyl Phenol Ethoxylate 12 Eo
SINOPOL 965
Ethoxylated Nonylphenol 13 Eo
Polyoxyethylated p-nonylphenol
SINOPOL 964
POLY(OXY-1,2-ETHANEDYIL),.ALPHA.-(NONYLPHENYL)-.OMEGA.-HYDROXY-
Nonylphenol polyethylene glycol ether
Nonyl Phenol Pure 5 (5.5 EO)
Nonyl Phenol 5 Eo
Silicone Emulsion Sm2163
Peg-10 Nonyl Phenyl Ether
Glycols, Polyehtylene, Mono(Nonylphenyl) Ether
Poly(oxy-1,2-ethanediyl),.alpha.-(nonyphenyl)-.omeg.-hydroxy
Methylhexylisopropylbenzylsiloxane
Nonyl Phenol 11 EO
Ethoxylated Nonyl Phenol Af9-8
Nonylphenoxypolyethoxy ethanol
Auxiliary Scouring Agent
Nonylphenol, ethylene oxide, condensate
PANNOX 15B (5.5 EO)
Nonyl Phenol Ethoxylate 6 Eo
Ethoxylated Nonyl Phenol
A730 (Surfactant)
Sinopol 908-S7
Nonyl Phenol 8 EO
Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-
Nonyl Phenol Ethoxylate 30 Eo Liquid
Nonylphenol, Polyoxyethylene Ether.
Nonyl Phenol Pure 40
Nonylphenol, polyethylene glycol ether
Glycols, phyethylene, mono (nonylphenyl) ether
PEG-30 Nonyl Phenyl Ether (30 EO)



NONYL PHENOL 10 EO
Nonyl Phenol 10 EO fall into the general chemical category of alkylphenols.
Nonyl Phenol 10 EO are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.
Nonyl Phenol 10 EO can come in numerous structures, all of which may be considered alkylphenols.

CAS: 25154-52-3
MF: C15H24O
MW: 220.35
EINECS: 246-672-0

Synonyms: nonyl;nonyl-pheno;nonylphenol(isomermixture);nonylphenol(mixedisomers);nonylphenol,mixedisomers;Phenol, nonyl-;Phenol,nonyl-;prevostselvon-100

Nonyl Phenol 10 EO used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonyl Phenol 10 EO used extensively in epoxy formulation in North America but its use has been phased out in Europe.
Nonyl Phenol 10 EO are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonyl Phenol 10 EO has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.
The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.
Nonyl Phenol 10 EO has been found to act as an agonist of the GPER (GPR30).

Nonyl Phenol 10 EO Chemical Properties
Melting point: 56.34°C (estimate)
Boiling point: bp 293-297°
Density: d420 0.950
Vapor density:7.59
Refractive index: nD20 1.513
Fp: (open cup) 300°F
Form: Clear, straw-colored liquid; technical grade is a mixture of isomers, predominantly para-substituted
Color: Clear, straw-colored, viscous liquid
Odor: Phenolic; like disinfectant.
CAS DataBase Reference: 25154-52-3(CAS DataBase Reference)
NIST Chemistry Reference: Nonyl Phenol 10 EO(25154-52-3)
EPA Substance Registry System: Nonyl Phenol 10 EO (25154-52-3)

Production
Nonyl Phenol 10 EO can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates.
Industrially, Nonyl Phenol 10 EO are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes.
This synthesis leads to a very complex mixture with diverse nonylphenols.

Nonyl Phenol 10 EO are also produced naturally in the environment.
One organism, the velvet worm, produces Nonyl Phenol 10 EO as a component of its defensive slime.
The nonylphenol coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted.
It also prolongs the drying process long enough for the slime to reach its target.

Uses
Nonyl Phenol 10 EO is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonyl Phenol 10 EO can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.
Barium and calcium salts of nonylphenol are also used as heat stabilizers for polyvinyl chloride (PVC).
Nonyl Phenol 10 EO is also often used an intermediate in the manufacture of the non-ionic surfactants nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonyl Phenol 10 EO and nonylphenol ethoxylates are only used as components of household detergents outside of Europe.
NONYL PHENOL 10,30,40
no cas: 68412-54-4, NP 10, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols, Nonylphenol, branched, ethoxylated ; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4) Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylpheno
NONYL PHENOL 30 EO 70 %
Nonyl Phenol 30 EO 70 % is a nonionic emulsifier for the emulsion polymerization industry, used to polymerize vinyl acetate with other vinyl esters, acrylates, vinyl chloride, and ethylene for acrylic and styrene/acrylic dispersions and butadiene/styrene latex.
Nonyl Phenol 30 EO 70 % has excellent resistance to compounds that cause hard water and metal salts, including heavy metals, acids, alkalis, reductive agents, and oxidative agents based on peroxide.
Nonyl Phenol 30 EO 70 % is a non-ionic surfactant used in wetting agents and stabilizers, emulsifiers and dispersants, cleaners and detergents, and agrochemicals; highly water-soluble, low odor, and suitable for use at higher temperatures.

CAS number: 9016-45-9
Molecular Weight: 1000-1500 g/mol.

Synonyms: Nonylphenol Ethoxylate 30 EO, NP-30, NPE-30, Nonylphenol Polyethylene Glycol Ether 30 EO, Nonoxynol-30, Nonylphenol, Ethoxylated (30 Moles), Nonyl Phenol Ethoxylate (30 moles of EO), Nonylphenol Ethoxylate, 70% Solution, Nonylphenoxy Polyethylene Oxide, Ethoxylated Nonyl Phenol (30 EO)

Nonyl Phenol 30 EO 70 % is a non-ionic surfactant finding application in various agricultural applications, including detergents, sanitizers, industrial cleaners, metal cleaners, textiles, and paper deinking.
Nonyl Phenol 30 EO 70 % is a nonionic emulsifier for the emulsion polymerization industry.

Nonyl Phenol 30 EO 70 % is used to polymerize vinyl acetate with other vinyl esters, acrylates, vinyl chloride, and ethylene for acrylic and styrene / acrylic dispersions and butadiene/styrene latex.
Using Nonyl Phenol 30 EO 70 % reduces coagulation and improves electrolyte resistance and freeze/thaw stability.

Nonyl Phenol 30 EO 70 % is added either during or after polymerization.
Nonyl Phenol 30 EO 70 % is also used as dispersing and wetting agent in pigment preparations, paints, and coatings.

Nonyl Phenol 30 EO 70 % is compatible with nonionic, anionic, or cationic substances.
Nonyl Phenol 30 EO 70 % has excellent resistance to compounds that cause hard water and metal salts, including heavy metals, acids, alkalis, reductive agents, and oxidative agents based on peroxide. 

Nonyl Phenol 30 EO 70 % is a non-ionic surfactant used in wetting agents and stabilizers, emulsifiers and dispersants, cleaners and detergents, and agrochemicals; Highly water soluble, low odor, and suitable for use at higher temperatures​​​​​.

Nonyl Phenol 30 EO 70 % is soluble in water.
Nonyl Phenol 30 EO 70 % is soluble in chlorinated solvents and most polar solvents, and Nonyl Phenol 30 EO 70 % is chemically stable in the presence of dilute acids, bases, and salts.

Nonyl Phenol 30 EO 70 % is a non-ionic surfactant.
Nonyl Phenol 30 EO 70 % is highly water-soluble emulsifier & stabilizer.

Uses of Nonyl Phenol 30 EO 70 % :
Nonyl Phenol 30 EO 70 % is used in wetting agents & stabilizers, emulsifiers & dispersants, agrochemicals, cleaners & detergents.

Nonyl Phenol 30 EO 70 % is used in the following applications:
Nonyl Phenol 30 EO 70 % is used as an emulsifier in emulsion polymerization

Nonyl Phenol 30 EO 70 % is used as a wax emulsifier
Nonyl Phenol 30 EO 70 % is used for pigment pastes

Nonyl Phenol 30 EO 70 % is used as a stabilizer in paints and coatings
Nonyl Phenol 30 EO 70 % is compatible with soaps, anionic and other nonionic surfactants, and many organic solvents.

Electrolytes, for example neutral salts, alkalis and – to a lesser extent – acids, reduce the water solubility of Nonyl Phenol 30 EO 70 % and may lead to their salting out, especially at high concentrations and temperatures.
For solutions containing high amounts of electrolytes, Nonyl Phenol 30 EO 70 % with long polyglycolether chains may be used since, being more hydrophilic, they are not so easily salted out.

Nonyl Phenol 30 EO 70 % is a unique nonionic wetting agent and emulsifier for aqueous systems.
Nonyl Phenol 30 EO 70 % has pigment wetting and stabilising properties in the paint industry.

Nonyl Phenol 30 EO 70 % is used in polymerization of vinyl acetate together with other vinyl esters, acrylates, vinyl chloride and ethylene, for acrylic and styrene / acrylic dispersions and for butadiene / styrene latex.
The use of Nonyl Phenol 30 EO 70 % reduces coagulation and improves electrolyte resistance and freeze/thaw stability.

Nonyl Phenol 30 EO 70 % is added either during or after polymerization.
Nonyl Phenol 30 EO 70 % is also used in pigment preparations,paints and coatings as dispersing and wetting agent.

Nonyl Phenol 30 EO 70 % is use for wetting agents and stabilizers, cleaners and detergents, emulsifiers and dispersants, and agrochemicals.
Nonyl Phenol 30 EO 70 % can also be used in oilfield drilling and production formulations.

Other Uses:
Cleaning product formulations
Paints and coatings
Emulsion polymerization
Anywhere there is a need for increased surface activity
Benefits
Deliver a combination of economy and performance
Excellent detergency and wetting
Good solubilization and emulsification

Applications of Nonyl Phenol 30 EO 70 % :

Nonyl Phenol 30 EO 70 % is widely used in various industrial applications, including:

Detergents and Cleaners:
Nonyl Phenol 30 EO 70 % is effective in removing oils and greases.

Emulsifiers:
Nonyl Phenol 30 EO 70 % is used in the formulation of emulsions for paints, coatings, and agricultural chemicals.

Textiles and Leather:
Nonyl Phenol 30 EO 70 % is used as wetting agents and dispersants in textile processing and leather manufacturing.

Industrial Processes:
Utilized in the formulation of lubricants, adhesives, and other chemical processes.

Benefits of Nonyl Phenol 30 EO 70 % :
Nonyl Phenol 30 EO 70 % delivers a combination of economy and performance
Nonyl Phenol 30 EO 70 % has excellent detergency and wetting properties
Nonyl Phenol 30 EO 70 % has good solubilization and emulsification properties

Typical Properties of Nonyl Phenol 30 EO 70 % :

Characteristics:
Both the chemical and processing characteristics of Nonyl Phenol 30 EO 70 % depend largely on the ratio of hydrophobic molecules (nonylphenol) to the hydrophilic – i.e. water solubilizing – polyglycolether chain (number of ethylene oxidemolecules).

Compatibility:
Being nonionic, Nonyl Phenol 30 EO 70 % is compatible with all other nonionic, anionic or cationic substances.

Stability:
Nonyl Phenol 30 EO 70 % has excellent resistance to compounds that cause hard water, to metal salts, including those of heavy metals, acids, alkalis, reductive agents and oxidative agents based on peroxide. 

Storage and Handling of Nonyl Phenol 30 EO 70 % :

Storage Conditions:
Store in a cool, dry place, away from direct sunlight and incompatible substances (e.g., strong acids, oxidizers)

Shelf Life:
Typically 1-2 years when stored under recommended conditions

Packaging:
Usually available in drums, totes, or bulk containers

Identifiers of Nonyl Phenol 30 EO 70 % :
A nonyl phenol poly glycol ether
CAS number: 9016-45-9
Composition: Nonylphenol polyglycol ether with 30 EO

Properties of Nonyl Phenol 30 EO 70 % :
Appearance: Typically a viscous, pale yellow liquid.
Odor: Mild, characteristic odor.
Solubility: Soluble in water and organic solvents due to the ethoxylation.
Molecular Weight: Varies depending on the degree of ethoxylation, but typically in the range of 1000-1500 g/mol.
pH: Usually neutral to slightly alkaline in aqueous solution (around 6-8).
Density: Approximately 1.02-1.06 g/cm³ at 25°C.
Viscosity: Viscous liquid, specific viscosity values depend on the exact formulation.
Cloud Point: The temperature at which the solution becomes cloudy, typically around 60-70°C for a 1% aqueous solution.

Appearance: Viscous, pale yellow liquid
Odor: Mild, characteristic odor
Density: 1.02 - 1.06 g/cm³ at 25°C
Viscosity: High, specific values depending on exact formulation
Solubility: Soluble in water and various organic solvents
Cloud Point: 60 - 70°C for a 1% aqueous solution
pH (1% Aqueous Solution): 6.0 - 8.0
Molecular Weight: Approximately 1000 - 1500 g/mol (varies with ethoxylation degree)

Active substance content: about 70 %

Appearance:
at 5°C: white paste
at 10°C: cloudy inhomogeneous liquid
at 15°C: clear, colorless liquid
at 25°C: clear, colorless liquid
at 40°C: clear, colorless liquid
pH value (DIN EN 1262), 1% in water: 6 - 8

HLB value: about 17
Density at 25 °C: approx. 1.09 g/cm³
Viscosity at 25 °C (Brookfield DV II, Spindle 4): about 990 mPas
Flashpoint (DIN/ISO 2592): > 100 °C

Other Nonyl Phenol grades:
Nonyl Phenol 4
Nonyl Phenol 6
Nonyl Phenol 8
Nonyl Phenol 10
Nonyl Phenol 11
Nonyl Phenol 13
Nonyl Phenol 15
Nonyl Phenol 23
Nonyl Phenol 100
NONYL PHENOL 40
Nonyl phenol 40 is a non-ionic surfactant belonging to the group of ethoxylated nonylphenols.
Nonyl phenol 40 is a white to light straw-coloured wax which solidifies at a temperature of about 35°C.
Nonyl phenol 40 fall into the general chemical category of alkylphenols.


CAS Number: 127087-87-0
EC Number: 500-315-8
MDL Number: MFCD00132411
Chemical Formula: C15H24O(C2H4O)x


Nonyl phenol 40 has good water solubility.
Nonyl phenol 40 has a cloud point in the temperature range of 72-76°C in a solution of NaCl 100 g/L.
Nonyl phenol 40's hydroxyl value is 24-32 mgKOH/g.


Nonyl phenol 40 is white to off white waxy solid /Flakes.
Nonyl phenol 40 acts as an emulsifier and dispersant, thus improving detergency properties.
Nonyl phenol 40 can be used in a mixture with other non-ionic auxiliaries and anionic and cationic agents.


Nonyl phenol 40 is highly water-soluble emulsifier & stabilizer Wetting.
Nonyl phenol 40 fall into the general chemical category of alkylphenols.
The structure of Nonyl phenols can vary.


Nonyl phenol 40 is insoluble in water.
Nonyl phenol 40's flash point is 285°F.
Nonyl phenol 40 is a component of washing and cleaning agents and laundry detergents.


The nonyl group can be attached to the phenol ring at various positions, usually the 4- and to a lesser extent 2-positions, and may be branched or linear.
Nonyl phenol 40 is soluble in chlorinated solvents and polar solvents.
Nonyl phenol 40 is a commercially available detergent.


Nonyl phenol 40 is an ethoxylated nonylphenol for non-ionic surfactants and can act as emulsifier and demulsifier agent.
Nonyl phenol 40 is a non-ionic surfactant belonging to the group of ethoxylated nonylphenols.
Nonyl phenol 40 is a white to light straw-coloured wax which solidifies at a temperature of about 35°C.


Nonyl phenol 40 is chemically stable in the presence of dilute acids, bases and salts
Nonyl phenol 40 has attracted attention for Nonyl phenol 40's potential role as an endocrine disruptor and xenoestrogen due to its prevalence in the environment and its ability to act with estrogen-like activity.


A branched nonylphenol, 4-nonylphenol, is the most widely produced and marketed nonylphenol.
The mixture of nonylphenol isomers is a pale yellow liquid, but pure compounds are colorless.
Nonyl phenol 40 is compatible with soaps, anionic and other nonionic surfactants, and many organic solvents


Nonyl phenol 40 are nonionic surfactants which are such as all kinds of other nonionic surfactants mixtures varying in the number of repeating ethoxy groups.
Nonyl phenol 40 is characterized by good resistance to oxidizing and reducing factors, as well as stability in acids and alkalis.
The digit which is appeared after the name of phenol shows the average number of carbon-tail units in the Nonylphenol molecule.


For example, Nonyl phenol 40 means a nonylphenol molecule which is reacted with average forty molecules of ethylene oxide.
Nonyl phenol 40 is a thick, yellowish liquid with a slight phenolic odor.
Nonyl phenol 40 has good water solubility.


Nonyl phenol 40 has a cloud point in the temperature range of 72-76°C in a solution of NaCl 100 g/L.
Nonyl phenol is a family of closely related organic compounds called alkylphenols.
Alkylphenols are used in the production of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.


These compounds are also present in nonionic surfactants such as alkylphenol ethoxylates and nonylphenol ethoxylates used in detergents, paints, pesticides, personal care products and plastics.
NPEs are a clear to light orange colored liquid.


Nonylphenol ethoxylates are non-ionic in water; this means they have no payload.
Because of this property, they are used as detergents, cleaners, emulsifiers and various applications.
They are amphipathic, meaning they have hydrophilic and hydrophobic properties; this allows them to surround non-polar substances such as oil and grease and insulate them from water.


Nonylphenols are moderately soluble in water but soluble in alcohol.
Nonylphenol originates from the environmental degradation of nonylphenol ethoxylates, which are metabolites in commercial detergents called alkylphenol ethoxylates.



USES and APPLICATIONS of NONYL PHENOL 40:
Nonyl phenol 40 is used as a wetting agent and emulsifier for production and refining and used as a cleaners and degreasers in textile processing.
Nonyl phenol 40 is a component of washing and cleaning agents and laundry detergents.
Nonyl phenol 40 acts as an emulsifier and dispersant, thus improving detergency properties.


Nonyl phenol 40 can be used in a mixture with other non-ionic auxiliaries and anionic and cationic agents.
Moreover, Nonyl phenol 40 is characterized by good resistance to oxidizing and reducing factors, as well as stability in acids and alkalis.
Nonyl phenol 40 is a non-ionic emulsifier in the emulsion polymerization process.


The highest effectiveness of Nonyl phenol 40 is achieved in combination with a suitable anionic surfactant, which provides control over the parameters of the reaction.
High degree of ethoxylation, and thus high hydrophilicity, ensures excellent stability of polymer dispersion in the presence of electrolytes (including hard water) and organic solvents.


Nonyl phenol 40 is compatible with a wide range of polymers and can be used in the production of acrylic, styrene-acrylic, homo- and vinyl acetate copolymers.
Typical application of Nonyl phenol 40 is 0.5-3% by weight of the total dispersion.
Nonyl phenol 40 is also used as an emulsifier for the production of bituminous masses and for the emulsification of asphalt.


Nonyl phenol 40 is also an emulsifying additive in the production of polyester resins.
Nonyl phenol 40 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonyl phenol 40 is used in the process for the manufacture of 5-nonyl salicylaldoxime, which is used for the selective purification and concentration of copper ions.


Nonyl phenol 40 is used Cleaners, Paint, Coatings, Solubilizing Agent, and Cleaning product formulations.
Nonyl phenol 40 is used in many epoxy formulations.
Due to Nonyl phenol 40's nonionic structure, Nonyl phenol 40 is compatible with anionic surfactants and is stable in the presence of acids, bases, and salts.


Nonyl phenol 40 is used Paints and coatings, Emulsion polymerization, Cleaners & degreasers, and Agrochemical.
Nonyl phenol 40 is used Paints and coatings, paper and textile processing, cleaners and detergents, agrochemicals, and metalworking fluids, oilfield drilling and production formulations.


Nonyl phenol 40 is used Tanning, Metalworking, Pulp and paper industry, Industrial cleaning,, Hard Surface Cleaners, Oil Well Drilling Fluids, and Textile.
Nonyl phenol 40 is used Nonionic surfactant for use in paper and textile processing, paints & coatings, and agrochemicals; featuring versatile solubility characteristics, high water solubility, suitability for use at higher temperatures​​​​​​​.


Nonyl phenol 40 is used Bituminous emulsions, and Cleaners & detergents
Nonyl phenol 40 is used Dispersant, Glass Cleaners, Metal Cleaners, Steam Cleaner, and Agricultural Emulsifier.
Nonyl phenol 40 can also be used to produce tris (4-nonyl-phenyl) phosphide (TNPP), an antioxidant used to protect polymers such as rubber, vinyl polymers, polyolefins and polystyrene.


Nonyl phenol 40 is a non-ionic emulsifier in the emulsion polymerization process.
Nonyl phenol 40 is compatible with a wide range of polymers and can be used in the production of acrylic, styrene-acrylic, homo- and vinyl acetate copolymers.
Typical application of Nonyl phenol 40 is 0.5-3% by weight of the total dispersion.


Nonyl phenol 40 is a high active nonionic surfactant finding application in a variety of agricultural applications, detergents, sanitizers, industrial cleaners, metal cleaners, textile applications, and paper deinking.
Nonyl phenol 40 is used as cleaners & detergents, degreasers, paper & textile processing, paints, prewash spotters, agrochemicals, metalworking fluids, oil field chemicals.


Nonyl phenol 40 is also used as an emulsifier for the production of bituminous masses and for the emulsification of asphalts.
Nonyl phenol 40 is also an emulsifying additive in the production of polyester resins.
Nonyl phenol 40 is used Oil in water emulsion, Metalworking fluid, Paint & coatings, and Textiles.


Nonyl phenol 40 is used Alkaline Cleaner, Cleaning Compounds, Deinking Paper, Degreaser, and Disinfectant Cleaners
Anywhere there is a need for increased surface activity.
Nonyl phenol 40 is used as emulsifier, washing agent, wetting agent, penetrating agent, dispersing agent, degreasing agent, refining agent and chemical intermediate in the industry.


Nonyl phenol 40 is used in the manufacture of oil additives, surfactants, fungicide preparations and plastics and rubber.
Nonyl phenol 40 is used Paper & textile processing, Paints & coatings, Agro-chemicals, and Metalworking fluids.
Nonyl phenol 40 can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.


Nonyl phenol 40 is used anywhere there is a need for increased
surface activity, and provide excellent all-purpose detergency and wetting, as well as solubilization and emulsification.
Nonyl phenol 40 has been widely used as an intermediate in the production of nonionic surfactants of the nonylphenol ethoxylate (NPE) type.


Nonyl phenol 40 are used as oil-soluble detergents and emulsifiers, lubricants, oil additives, and antioxidants for rubber manufacture.
Nonyl phenol 40 is often used to break open all membranes within a cell, including the nuclear membrane.
Nonyl phenol 40 is an alkylphenol which is widely used as non-ionic surfactants, nonylphenol ethoxylate (NPEO) and octylphenol ethoxylate being the main representatives of this group.


Nonyl phenol 40 can be used in emulsifying applications.
Nonyl phenol 40 is used Excellent emulsifier, wetting agent, stabilizer, couples detergent range nonionics into hydrocarbon systems.
Nonyl phenol 40 has applications in paper and textile processing, in paints and coatings, and in agrochemical manufacturing.


Nonyl phenol 40 is used Car Wash Soap, Dairy Cleaners, Detergents, Textile, and Sanitizers.
Nonyl phenol 40 is used as heat stabilizers for polyvinyl chloride (PVC).
Nonyl phenol 40 is also used as heat stabilizers for polyvinyl chloride (PVC).


Nonyl phenol 40 is also often used an intermediate in the manufacture of the non-ionic surfactants nonylphenol exthoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonyl phenol 40 is a high active nonionic surfactant finding application in a variety of agricultural applications, detergents, sanitizers, industrial cleaners, metal cleaners, textiles, and paper deinking.


Nonyl phenol 40 is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.
Nonyl phenol 40 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonyl phenol 40 is a non-ionic surfactant which belongs to the group of ethoxylated nonylphenols.


Nonyl phenol 40 is used as a detergent, washing and cleaning agent and as an emulsifier.
Nonyl phenol 40 is nonionic and provides excellent detergency, outstanding wetting, versatile solubility characteristics and low odor.
Nonyl phenol 40 is used Excellent detergency, outstanding wetting, good rinseability.


Nonyl phenol 40 is suggested for use in paper & textile processing, paints & coatings and agrochemicals.
Nonyl phenol 40 is used Acid Cleaners, Penetrant, Concrete Cleaners, and Dispersant.
Nonyl phenol 40 is used as a wetting agent and emulsifier in emulsion polymerization, drilling and production.


Nonyl phenol 40 is used in paper & textile processing, paints & coatings and agrochemicals.
Nonyl phenol 40 is used Excellent oil-soluble surfactant, low HLB emulsifier.
Nonyl phenol 40 is used Cleaners & degreasers, dry cleaning


Nonyl phenol 40 is used Cleaners & detergents, paper & textile processing, laundry, paints & coatings, dust control, agrochemicals, metalworking fluids
Nonyl phenol 40 is used Excellent detergency, outstanding wetting, versatile solubility characteristics, and exceptional handling properties.
Nonyl phenol 40 is used by various industries, such as Oil & Gas, Crop Solutions and Home Care and I&I, and act as wetting agents, solubilizers, detergents, dispersants, emulsifiers, and degreasers.


Nonyl phenol 40 is a nonionic surfactant used in the isolation of membrane complexes.
Nonionic surfactant for use in paints and coatings, paper and textile processing, cleaners and detergents, agrochemicals, and metalworking fluids.
Nonyl phenol 40 is used Excellent detergency, outstanding wetting, versatile solubility characteristics, and exceptional handling properties.


Nonyl phenol 40 can also be used in oilfield drilling and production formulations.
Nonyl phenol 40 is used Cleaners, degreasers, dry cleaning, adhesives, agrochemicals
Nonyl phenol 40 is used in a wide variety of applications, for instance detergent formulations, emulsifiers in many industries, paints and coatings, emulsion polymerization, and many others.


Nonyl phenol 40 is used as components of household detergents.
Nonyl phenol 40 is used in a wide variety of applications, for instance detergent formulations, emulsifiers in many industries, paints and coatings, emulsion polymerization, and many others.


Nonyl phenol 40 is used anywhere there is a need for increased surface activity, and provide excellent all-purpose detergency and wetting, as well as solubilization and emulsification.
Nonyl phenol 40 is important in the production of laundry detergents.


Nonyl phenol 40 is used as emulsifier & detergent for textile, paint, agrochemicals, cleaners formulation
Nonyl phenol 40 is used in the production of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
Nonyl phenol 40 is a stabilizer in plastic food packaging.


-Uses of Nonyl phenol 40:
*Cleaning product formulations
*Paints and coatings
*Emulsion polymerization
*Anywhere there is a need for increased surface activity


-Applications of Nonyl phenol 40:
*emulsion polymerization,
*industrial cleaning,
*bituminous emulsions.



ADVANTAGES OF NONYL PHENOL 40:
*non-ionic emulsifier in emulsion polymerization,
*efficiently interacts with the anionic surfactant and controls the emulsion polymerization reaction parameters,
*improves the stability of polymer dispersion,
*compatible with a wide range of polymers,
*good resistance to electrolytes.
*Oustanding wetting
*Effective at high temperatures
*Highly water-soluble emulsifier & stabilizer
*Versatile solubility characteristics
*Low odor
*Excellent detergency



BENEFITS of NONYL PHENOL 40:
*Effective at high temperatures
*Highly water-soluble emulsifier & stabilizer
*Wetting
*Versatile solubility characteristics
*Low odor
*Detergency
*Deliver a combination of economy and performance
*Excellent detergency and wetting
*Good solubilization and emulsification



NONYL PHENOLS:
Nonyl phenols, from the Latin nōnus (number 9) and phenol, are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.
Nonyl phenols can come in numerous structures, all of which may be considered alkylphenols.
Nonyl phenols are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.

Nonyl phenols are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonyl phenol has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.

The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.
Nonylphenol has been found to act as an agonist of the GPER (GPR30).
Nonylphenols fall into the general chemical category of alkylphenols.

The structure of NPs may vary.
The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear.
A branched nonylphenol, 4-nonylphenol, is the most widely produced and marketed nonylphenol.

The mixture of nonylphenol isomers is a pale yellow liquid, although the pure compounds are colorless.
The nonylphenols are moderately soluble in water but soluble in alcohol.
Nonyl phenol arises from the environmental degradation of nonylphenol ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates.

Nonyl phenol ethoxylates are a clear to light orange color liquid.
Nonylphenol ethoxylates are nonionic in water, which means that they have no charge.
Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications.

They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.
Nonylphenol persists in aquatic environments and is moderately bioaccumulative.
It is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments.

Nonbiological degradation is negligible.
In sewage treatment plants, nonylphenol ethoxylate degrades into nonylphenol, which is found in river water and sediments as well as soil and groundwater.
Nonylphenol photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years.
Although the concentration of nonylphenol in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.
Nonylphenol is not persistent in air, as it is rapidly degraded by hydroxyl radicals.



PRODUCTION of NONYL PHENOLS:
Nonylphenol can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates.
Industrially, nonylphenols are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes.
This synthesis leads to a very complex mixture with diverse nonylphenols.

Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.
To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.
Since its discovery in 1940, nonylphenol production has increased exponentially, and between 100 and 500 million pounds of nonylphenol are produced globally every year, meeting the definition of High Production Volume Chemicals.

Nonylphenols are also produced naturally in the environment.
One organism, the velvet worm, produces nonylphenol as a component of its defensive slime.
The nonylphenol coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted.

It also prolongs the drying process long enough for the slime to reach its target.
Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free nonylphenol when administered to lab animals.



PHYSICAL and CHEMICAL PROPERTIES of NONYL PHENOL 40:
Molecular Weight: 220.35
XLogP3: 5.9
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 8
Exact Mass: 220.182715385
Monoisotopic Mass: 220.182715385
Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 16
Formal Charge: 0
Complexity: 148
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Appearance @ 20˚C: White Solid
Color: Max. 50
Viscosity @ 50˚C: ca. 220
Density @ 50˚C: 1.07±0.02g/cm3
pH (5% in water): 5-7
HLB: 17.8
(1% in NaCl 10%): 76 – 80˚C
Hydroxyl value: 26 – 30 mgKOH/g
Water: Max. 0.5
Melting point: 43-44°C
Boiling point: 293-297 °C
Density: 0.937 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.511(lit.)
Flash point: >230 °F
Storage temp.: APPROX 20°C
Solubility: Sparingly Soluble (0.020 g/L) at 25°C.

Form: neat
pka: 6.15±0.15(Predicted)
Specific Gravity: ~1.057
Color: Clear colorless
Odor: Phenol like
PH Range: 6 - 8
Water Solubility: 6.35mg/L(25 ºC)
ΔfG°: 33.21 kJ/mol
ΔfH°gas: -293.71 kJ/mol
ΔfusH°: 34.43 kJ/mol
ΔvapH°: 64.27 kJ/mol
logPoct/wat: 4.685
Pc: 2108.07 kPa
Tboil: 649.90 K
Tc: 851.69 K
Tfus: 396.95 K
Vc: 0.734 m3/kg-mol



FIRST AID MEASURES of NONYL PHENOL 40:
-General advice:
Consult a physician.
-If inhaled:
Fresh air.
-In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
-In case of eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
-If swallowed:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NONYL PHENOL 40:
-Personal precautions, protective equipment and emergency procedures:
*Advice for non-emergency personnel:
Ensure adequate ventilation.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NONYL PHENOL 40:
-Extinguishing media:
*Suitable extinguishing media:
Water Foam Carbon dioxide (CO2) Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NONYL PHENOL 40:
-Control parameters:
*Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use safety glasses
*Body Protection:
Use protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NONYL PHENOL 40:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
-Specific end use(s):
No other specific uses are stipulated.



STABILITY and REACTIVITY of NONYL PHENOL 40:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
HSDB 5359
BRN 2047450
paranonylphenol
nonyl-phenol
p-nonyl-phenol
Para-nonyl phenol
4-Nonylphenol, tech.
Spectrum_001973
SpecPlus_000624
P-NONYLPHENOL
Spectrum2_001832
Spectrum5_002066
4-n-Nonylphenol, 85%
4-n-Nonylphenol, 98%
BIDD:PXR0002
SCHEMBL15887
BSPBio_002543
KBioGR_001263
KBioSS_002539
SPECTRUM330085
BIDD:ER0006
DivK1c_006720
SPBio_001903
CHEMBL153062
4-Nonylphenol-2,3,5,6-d4
KBio1_001664
KBio2_002530
KBio2_005098
KBio2_007666
KBio3_002043
4-Nonylphenol, analytical standard
ZINC1850497
Tox21_201241
LMPK15010001
STL453644
AKOS015888197
MCULE-5930378829
NCGC00090918-01
NCGC00090918-02
NCGC00090918-03
NCGC00090918-05
NCGC00090918-06
NCGC00090918-07
NCGC00090918-08
NCGC00257420-01
NCGC00258793-01
FT-0619310
FT-0673035
4-n-Nonylphenol 10 microg/mL in Acetonitrile
4-n-Nonylphenol 10 microg/mL in Cyclohexane
4-n-Nonylphenol 100 microg/mL in Cyclohexane
4-Nonylphenol, PESTANAL(R), analytical standard
SR-05000002459
J-001167
Q4545806
SR-05000002459-1
4-Nonylphenol, certified reference material, TraceCERT(R)
Nonylphenol, ethoxylated
NPE
nonoxynol-40
polyethylene glycol
polyethylene glycol nonylphenol ether
Poly(oxy-1, 2-ethanediyl)
.alpha.-(4-nonylphenyl)-.omega.-hydroxy-, branched
Poly(oxy-1, 2-ethanediyl)
alpha-(4-nonylphenyl)-omega- hydroxy-
branched, Poly(oxy-1, 2-ethanediyl)
alpha.-(4-nonylphenyl)-.omega.-hydroxy-branched
Polyethylene glycol
mono(p-nonylphenyl) ether, branched
Nonylphenol polyethylene glycol ether
Poly(oxy-1, 2-ethanediyl)-
alpha- (4-nonylphenyl)-omega-hydroxy-
4-nonylphenol
4-n-Nonylphenol
p-Nonylphenol
para-Nonylphenol
p-n-Nonylphenol
Phenol, 4-nonyl-
4-nonyl phenol
Phenol, p-nonyl-
Nonylphenol (mixed)
Phenol, nonyl derivs.
para Nonyl phenol
4-Nonyl-Phenol
p -n -Nonylphenol
p-nonyl phenol
4-n-Nonyl phenol
DTXSID5033836
DSSTox_CID_1857
DSSTox_RID_79098
DSSTox_GSID_33836
4-NP
CCRIS 1251

NONYLPENOL (MNP) – Phenol,4-Nonyl-,Branched
SYNONYMS Phenol, 4-isononyl-;4-Isononyl-phenol;branched4-nonylphenol;4-Nonylphenol, branched;Phenol, 4-nonyl-, branched CAS NO:26543-97-5
Nonylphenol
Nonylphenol( Isomer Mixture); Monononylphenol; Hydroxyl Number 253; Dimethylheptylphenol; Nonylphenol (German); Nonilfenol (Spanish); Nonylphénol (French); cas no: 25154-52-3
NONYLPHENOL
DESCRIPTION:
Nonylphenols are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.
Nonylphenols can come in numerous structures, all of which may be considered alkylphenols.
Nonylphenols are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.

CAS No.: 84852-15-3
EC No.: 284-325-5
Empirical Formula (Hill Notation): C15H24O
Molecular Weight: 220.35

Nonylphenols are used extensively in epoxy formulation in North America but its use has been phased out in Europe.
Nonylphenols are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonylphenol has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.

The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.
Nonylphenol has been found to act as an agonist of the GPER (GPR30).

Nonylphenol (NP) is an aliphatic phenol compound with the chemical formula C15H24O.
NP plays a role in the manufacturing of polymers, plastics, and rubber.

The diverse biological, biochemical, and physiological effects of nonylphenol have garnered significant attention, leading to extensive research.
While the exact mechanism of action of nonylphenol remains partially understood, it is believed to exert its effects by interacting with the estrogen receptor, as evidenced by its in vitro binding affinity.



Nonylphenol is an organic compound of the wider family of alkylphenols.
Nonylphenol is a product of industrial synthesis formed during the alkylation process of phenols, particularly in the synthesis of polyethoxylate detergents.
Because of their man-made origins, nonylphenols are classified as xenobiotics.

In nonylphenols, a hydrocarbon chain of nine carbon atoms is attached to the phenol ring in either the ortho (2), meta (3), or para (4) position, with the most common ring isomers being ortho or para (e.g. figure 1 para-nonylphenol).

Moreover, the alkyl chains can exist as either linear n-alkyl chains, or complex branched chains.
Nonylphenol is commonly obtained as a mixture of isomers, and is thus usually found as a pale yellow liquid at room temperature with a freezing point of -10°C and a boiling point of 295-320°C.
However, pure isomers of nonylphenol crystallize readily at room temperatures and for example, para-n-nonylphenol, forms white crystals at room temperature.


STRUCTURE AND BASIC PROPERTIES OF NONYLPHENOL:
Nonylphenols fall into the general chemical category of alkylphenols.
The structure of NPs may vary.
The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear.


A branched nonylphenol, 4-nonylphenol, is the most widely produced and marketed nonylphenol.
The mixture of nonylphenol isomers is a pale yellow liquid, although the pure compounds are colorless.
The nonylphenols are moderately soluble in water but soluble in alcohol.

Nonylphenol arises from the environmental degradation of nonylphenol ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates.
NPEs are a clear to light orange color liquid.
Nonylphenol ethoxylates are nonionic in water, which means that they have no charge.

Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications.
They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.

PRODUCTION OF NONYLPHENOL:
Nonylphenol can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates.
Industrially, nonylphenols are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes.
This synthesis leads to a very complex mixture with diverse nonylphenols.

Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.
To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.
Since its discovery in 1940, nonylphenol production has increased exponentially, and between 100 and 500 million pounds of nonylphenol are produced globally every year, meeting the definition of High Production Volume Chemicals.

Nonylphenols are also produced naturally in the environment.
One organism, the velvet worm, produces nonylphenol as a component of its defensive slime.
The nonylphenol coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted.
It also prolongs the drying process long enough for the slime to reach its target.

Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free nonylphenol when administered to lab animals.

APPLICATIONS OF NONYLPHENOL:
Nonylphenol is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
Nonylphenol can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.
Barium and calcium salts of nonylphenol are also used as heat stabilizers for polyvinyl chloride (PVC).

Nonylphenol is also often used an intermediate in the manufacture of the non-ionic surfactants nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Nonylphenol and nonylphenol ethoxylates are only used as components of household detergents outside of Europe.
Nonyl Phenol, is used in many epoxy formulations mainly in North America.

PREVALENCE OF NONYLPHENOL IN THE ENVIRONMENT:
Nonylphenol persists in aquatic environments and is moderately bioaccumulative.
Nonylphenol is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments.
Nonbiological degradation is negligible.

Nonylphenol is partially removed during municipal wastewater treatment due to sorption to suspended solids and biotransformation.
Many products that contain nonylphenol have "down-the-drain" applications, such as laundry and dish soap, so the contaminants are frequently introduced into the water supply.

In sewage treatment plants, nonylphenol ethoxylate degrades into nonylphenol, which is found in river water and sediments as well as soil and groundwater.
Nonylphenol photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years.
Although the concentration of nonylphenol in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.

A major concern is that contaminated sewage sludge is frequently recycled onto agricultural land.
The degradation of nonylphenol in soil depends on oxygen availability and other components in the soil.
Mobility of nonylphenol in soil is low.

Bioaccumulation is significant in water-dwelling organisms and birds, and nonylphenol has been found in internal organs of certain animals at concentrations of 10 to 1,000 times greater than the surrounding environment.
Due to this bioaccumulation and persistence of nonylphenol, it has been suggested that nonylphenol could be transported over long distances and have a global reach that stretches far from the site of contamination.
Nonylphenol is not persistent in air, as it is rapidly degraded by hydroxyl radicals

ANALYTICS OF NONYLPHENOL:
There are standard GC-MS and HPLC protocols for the detection of nonylphenols within environmental sample matrices such as foodstuffs, drinking water and biological tissue.
Industrially produced nonylphenol (the source most likely to be found in the environment) contains a mixture of structural isomers, and while these protocols are able to detect this mixture, they are typically unable to resolve the individual nonylphenol isomers within it.

However, a methodological study has indicated that better isomeric resolution can be achieved in bulk nonylphenol samples using a GC-MS/MS (tandem mass-analyzer) system, suggesting that this technique could also improve the resolution of nonylphenol isomers in environmental sample analyses; further improvements in the resolution of nonylphenol isomers have been achieved through the use of two-dimensional GC at the separation stage, as part of a GC x GC-TOF-MS system.

In contrast to environmental sample analyses, synthetic studies of nonylphenols have more control over sample state, concentration and preparation, simplifying the use of powerful structural identification techniques like NMR - capable of identifying the individual nonylphenol isomers.
In a preliminary investigation of the relationship between nonylphenol sidechain branching patterns and estrogenic potential, the authors identified 211 possible structural isomers of p-nonylphenol alone, which expanded to 550 possible p-nonylphenol compounds when taking chiral C-atoms into consideration.
Because stereochemical factors are thought to contribute to the biological activity of nonylphenols, analytical techniques sensitive to chirality, such as enantioselective HPLC and certain NMR protocols, are desirable in order to further study these relationships.

REGULATIONS OF NONYLPHENOL:
The production and use of nonylphenol and nonylphenol ethoxylates is prohibited for certain situations in the European Union due to its effects on health and the environment.
In Europe, due to environmental concerns, they also have been replaced by more expensive alcohol ethoxylates, which are less problematic for the environment due to their ability to degrade more quickly than nonylphenols.
The European Union has also included NP on the list of priority hazardous substances for surface water in the Water Framework Directive.

They are now implementing a drastic reduction policy of NP's in surface waterways.
The Environmental quality standard for NP was proposed to be 0.3 ug/L.
In 2013 nonylphenols were registered on the REACH candidate list.

In the US, the EPA set criteria which recommends that nonylphenol concentration should not exceed 6.6 ug/L in fresh water and 1.7 ug/L in saltwater.
In order to do so, the EPA is supporting and encouraging a voluntary phase-out of nonylphenol in industrial laundry detergents.
Similarly, the EPA is documenting proposals for a "significant new use" rule, which would require companies to contact the EPA if they decided to add nonylphenol to any new cleaning and detergent products.

They also plan to do more risk assessments to ascertain the effects of nonylphenol on human health and the environment.
In other Asian and South American countries nonylphenol is still widely available in commercial detergents, and there is little regulation.




SAFETY INFORMATION ABOUT NONYLPHENOL:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product





CHEMICAL AND PHYSICAL PROPERTIES OF NONYLPHENOL:
Chemical formula C15H24O
Molar mass 220.35 g/mol
Appearance Light yellow viscous liquid with phenolic smell
Density 0.953
Melting point −8 to 2 °C (18 to 36 °F; 265 to 275 K)
Boiling point 293 to 297 °C (559 to 567 °F; 566 to 570 K)
Solubility in water 6 mg/L (pH 7)





NONYLPHENOL 10
NONYLPHENOL 10 NP-10 (NONYLPHENOL) Nonylphenol 10s, from the Latin nōnus (number 9) and phenol, are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail. Nonylphenol 10s can come in numerous structures, all of which may be considered alkylphenols. They are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] These compounds are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and Nonylphenol 10 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. Nonylphenol 10 has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.[3] The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.[4][5][6] Nonylphenol 10 has been found to act as an agonist of the GPER (GPR30).[7] Contents 1 Structure and basic properties 2 Production 3 Applications 4 Prevalence in the environment 4.1 Environmental hazards 5 Human health hazards 5.1 Effects in pregnant women 5.2 Effects on metabolism 5.3 Cancer 5.4 Human exposure and breakdown 5.4.1 Exposure 5.4.2 Breakdown 6 Analytics 7 Regulation 8 References Structure and basic properties Nonylphenol 10s fall into the general chemical category of alkylphenols.[8] The structure of NPs may vary. The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear. A branched Nonylphenol 10, 4-Nonylphenol 10, is the most widely produced and marketed Nonylphenol 10.[9] The mixture of Nonylphenol 10 isomers is a pale yellow liquid, although the pure compounds are colorless. The Nonylphenol 10s are moderately soluble in water [9] but soluble in alcohol. Nonylphenol 10 arises from the environmental degradation of Nonylphenol 10 ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates. NPEs are a clear to light orange color liquid. Nonylphenol 10 ethoxylates are nonionic in water, which means that they have no charge. Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications. They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.[2] Production Nonylphenol 10 can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates. Industrially, Nonylphenol 10s are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes. This synthesis leads to a very complex mixture with diverse Nonylphenol 10s.[10][11][12] Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.[4] To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.[9] Since its discovery in 1940, Nonylphenol 10 production has increased exponentially, and between 100 and 500 million pounds of Nonylphenol 10 are produced globally every year,[9][13] meeting the definition of High Production Volume Chemicals. Nonylphenol 10s are also produced naturally in the environment. One organism, the velvet worm, produces Nonylphenol 10 as a component of its defensive slime. The Nonylphenol 10 coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted. It also prolongs the drying process long enough for the slime to reach its target.[14] Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free Nonylphenol 10 when administered to lab animals.[8] Applications Nonylphenol 10 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] It can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging. Barium and calcium salts of Nonylphenol 10 are also used as heat stabilizers for polyvinyl chloride (PVC).[15] Nonylphenol 10 is also often used an intermediate in the manufacture of the non-ionic surfactants Nonylphenol 10 exthoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. Nonylphenol 10 and Nonylphenol 10 ethoxylates are only used as components of household detergents outside of Europe.[2] Nonyl Phenol, is used in many epoxy formulations mainly in North America. Prevalence in the environment Nonylphenol 10 persists in aquatic environments and is moderately bioaccumulative. It is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments. Nonbiological degradation is negligible.[3] Many products that contain Nonylphenol 10 have "down-the-drain" applications, such as laundry and dish soap, so the contaminants are frequently introduced into the water supply. In sewage treatment plants, Nonylphenol 10 ethoxylate degrades into Nonylphenol 10, which is found in river water and sediments as well as soil and groundwater.[16] Nonylphenol 10 photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years. Although the concentration of Nonylphenol 10 in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.[2] A major concern is that contaminated sewage sludge is frequently recycled onto agricultural land. The degradation of Nonylphenol 10 in soil depends on oxygen availability and other components in the soil. Mobility of Nonylphenol 10 in soil is low.[2] Bioaccumulation is significant in water-dwelling organisms and birds, and Nonylphenol 10 has been found in internal organs of certain animals at concentrations of 10 to 1,000 times greater than the surrounding environment.[3] Due to this bioaccumulation and persistence of Nonylphenol 10, it has been suggested that Nonylphenol 10 could be transported over long distances and have a global reach that stretches far from the site of contamination.[17] Nonylphenol 10 is not persistent in air, as it is rapidly degraded by hydroxyl radicals.[3] Environmental hazards Nonylphenol 10 is considered to be an endocrine disruptor due to its ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms.[4][5][6][18][19][20] The effect is weak because Nonylphenol 10s are not very close structural mimics of estradiol, but the levels of Nonylphenol 10 can be sufficiently high to compensate. Structure of the hormone estradiol and one of the Nonylphenol 10s. The effects of Nonylphenol 10 in the environment are most applicable to aquatic species. Nonylphenol 10 can cause endocrine disruption in fish by interacting with estrogen receptors and androgen receptors. Studies report that Nonylphenol 10 competitively displaces estrogen from its receptor site in rainbow trout.[21] It has a stronger affinity to the E2 receptor than estrogen.[21] Nonylphenol 10 causes the feminization of aquatic organisms, decreases male fertility, and decreases survival in young fish.[2] Studies show that male fish exposed to Nonylphenol 10 have lower testicular weight.[21] Nonylphenol 10 can disrupt steroidogenesis in the liver. One function of endogenous estrogen in fish is to stimulate the liver to make vitellogenin, which is a phospholipoprotein.[21] Vitellogenin is released by the maturing female and sequestered by developing oocytes to produce the egg yolk.[21] Males do not normally produce vitellogenin, but when exposed to Nonylphenol 10 they produce similar levels of vitellogenin to females.[21] The concentration needed to induce vitellogenin production in fish is 10 ug/L for NP in water.[21] Nonylphenol 10 can also interfere with the level of FSH (follicle-stimulating hormone) being released from the pituitary gland. Concentrations of NP that inhibit reproductive development and function in fish also damages kidneys, decreases body weight, and induces stressed behavior.[22] Human health hazards Alkylphenols like Nonylphenol 10 and bisphenol A have estrogenic effects in the body. They are known as xenoestrogens.[23] Estrogenic substances and other endocrine disruptors are compounds that have hormone-like effects in both wildlife and humans. Xenoestrogens usually function by binding to estrogen receptors and acting competitively against natural estrogens. Nonylphenol 10 has been shown to mimic the natural hormone 17β-estradiol, and it competes with the endogeous hormone for binding with the estrogen receptors ERα and ERβ.[2] Nonylphenol 10 was discovered to have hormone-like effects by accident because it contaminated other experiments in laboratories that were studying natural estrogens that were using polystyrene tubes.[8] Nonylphenol 10 From Wikipedia, the free encyclopedia Jump to navigationJump to search Nonylphenol 10 Nonylphenol 10es V.svg Names IUPAC name 4-(2,4-dimethylheptan-3-yl)phenol Other names Phenol, nonyl- Identifiers CAS Number 25154-52-3 (general class) check 104-40-5 (4-n-Nonyl phenol) check 84852-15-3 (branched 4-Nonyl phenols) check 11066-49-2 (isoNonylphenol 10s) ☒ 3D model (JSmol) Interactive image ChEMBL ChEMBL153062 ☒ ChemSpider 60628 check PubChem CID 67296 UNII 79F6A2ILP5 (general class) check I03GBV4WEL (4-n-Nonyl phenol) check JRW3Q994VG (branched 4-Nonyl phenols) check InChI[show] SMILES[show] Properties Chemical formula C15H24O Molar mass 220.35 g/mol Appearance Light yellow viscous liquid with phenolic smell [1] Density 0.953 Melting point −8 to 2 °C (18 to 36 °F; 265 to 275 K) Boiling point 293 to 297 °C (559 to 567 °F; 566 to 570 K) Solubility in water 6 mg/L (pH 7) Hazards Main hazards low level endrocrine disruptor Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references Nonylphenol 10s are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail. Nonylphenol 10s can come in numerous structures, all of which may be considered alkylphenols. They are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] These compounds are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and Nonylphenol 10 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. Nonylphenol 10 has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.[3] The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.[4][5][6] Nonylphenol 10 has been found to act as an agonist of the GPER (GPR30).[7] Contents 1 Structure and basic properties 2 Production 3 Applications 4 Prevalence in the environment 4.1 Environmental hazards 5 Human health hazards 5.1 Effects in pregnant women 5.2 Effects on metabolism 5.3 Cancer 5.4 Human exposure and breakdown 5.4.1 Exposure 5.4.2 Breakdown 6 Analytics 7 Regulation 8 References Structure and basic properties Nonylphenol 10s fall into the general chemical category of alkylphenols.[8] The structure of NPs may vary. The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear. A branched Nonylphenol 10, 4-Nonylphenol 10, is the most widely produced and marketed Nonylphenol 10.[9] The mixture of Nonylphenol 10 isomers is a pale yellow liquid, although the pure compounds are colorless. The Nonylphenol 10s are moderately soluble in water [9] but soluble in alcohol. Nonylphenol 10 arises from the environmental degradation of Nonylphenol 10 ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates. NPEs are a clear to light orange color liquid. Nonylphenol 10 ethoxylates are nonionic in water, which means that they have no charge. Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications. They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.[2] Production Nonylphenol 10 can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates. Industrially, Nonylphenol 10s are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes. This synthesis leads to a very complex mixture with diverse Nonylphenol 10s.[10][11][12] Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.[4] To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.[9] Since its discovery in 1940, Nonylphenol 10 production has increased exponentially, and between 100 and 500 million pounds of Nonylphenol 10 are produced globally every year,[9][13] meeting the definition of High Production Volume Chemicals. Nonylphenol 10s are also produced naturally in the environment. One organism, the velvet worm, produces Nonylphenol 10 as a component of its defensive slime. The Nonylphenol 10 coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted. It also prolongs the drying process long enough for the slime to reach its target.[14] Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free Nonylphenol 10 when administered to lab animals.[8] Applications Nonylphenol 10 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] It can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging. Barium and calcium salts of Nonylphenol 10 are also used as heat stabilizers for polyvinyl chloride (PVC).[15] Nonylphenol 10 is also often used an intermediate in the manufacture of the non-ionic surfactants Nonylphenol 10 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. Nonylphenol 10 and Nonylphenol 10 ethoxylates are only used as components of household detergents outside of Europe.[2] Nonyl Phenol, is used in many epoxy formulations mainly in North America. Prevalence in the environment Nonylphenol 10 persists in aquatic environments and is moderately bioaccumulative. It is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments. Nonbiological degradation is negligible.[3] Nonylphenol 10 is partially removed during municipal wastewater treatment due to sorption to suspended solids and biotransformation.[16][17] Many products that contain Nonylphenol 10 have "down-the-drain" applications, such as laundry and dish soap, so the contaminants are frequently introduced into the water supply. In sewage treatment plants, Nonylphenol 10 ethoxylate degrades into Nonylphenol 10, which is found in river water and sediments as well as soil and groundwater.[18] Nonylphenol 10 photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years. Although the concentration of Nonylphenol 10 in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.[2] A major concern is that contaminated sewage sludge is frequently recycled onto agricultural land. The degradation of Nonylphenol 10 in soil depends on oxygen availability and other components in the soil. Mobility of Nonylphenol 10 in soil is low.[2] Bioaccumulation is significant in water-dwelling organisms and birds, and Nonylphenol 10 has been found in internal organs of certain animals at concentrations of 10 to 1,000 times greater than the surrounding environment.[3] Due to this bioaccumulation and persistence of Nonylphenol 10, it has been suggested that Nonylphenol 10 could be transported over long distances and have a global reach that stretches far from the site of contamination.[19] Nonylphenol 10 is not persistent in air, as it is rapidly degraded by hydroxyl radicals.[3] Environmental hazards Nonylphenol 10 is considered to be an endocrine disruptor due to its ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms.[4][5][6][20][21] The effect is weak because Nonylphenol 10s are not very close structural mimics of estradiol, but the levels of Nonylphenol 10 can be sufficiently high to compensate. Structure of the hormone estradiol and one of the Nonylphenol 10s. The effects of Nonylphenol 10 in the environment are most applicable to aquatic species. Nonylphenol 10 can cause endocrine disruption in fish by interacting with estrogen receptors and androgen receptors. Studies report that Nonylphenol 10 competitively displaces estrogen from its receptor site in rainbow trout.[22] It has much less affinity for the estrogen receptor than estrogen in trout (5 x 10−5 relative binding affinity compared to estradiol) making it 100,000 times less potent than estradiol.[22][23] Nonylphenol 10 causes the feminization of aquatic organisms, decreases male fertility, and decreases survival in young fish.[2] Studies show that male fish exposed to Nonylphenol 10 have lower testicular weight.[22] Nonylphenol 10 can disrupt steroidogenesis in the liver. One function of endogenous estrogen in fish is to stimulate the liver to make vitellogenin, which is a phospholipoprotein.[22] Vitellogenin is released by the maturing female and sequestered by developing oocytes to produce the egg yolk.[22] Males do not normally produce vitellogenin, but when exposed to Nonylphenol 10 they produce similar levels of vitellogenin to females.[22] The concentration needed to induce vitellogenin production in fish is 10 ug/L for NP in water.[22] Nonylphenol 10 can also interfere with the level of FSH (follicle-stimulating hormone) being released from the pituitary gland. Concentrations of NP that inhibit reproductive development and function in fish also damages kidneys, decreases body weight, and induces stressed behavior.[24] Human health hazards Alkylphenols like Nonylphenol 10 and bisphenol A have estrogenic effects in the body. They are known as xenoestrogens.[25] Estrogenic substances and other endocrine disruptors are compounds that have hormone-like effects in both wildlife and humans. Xenoestrogens usually function by binding to estrogen receptors and acting competitively against natural estrogens. Nonylphenol 10 has been shown to mimic the natural hormone 17β-estradiol, and it competes with the endogeous hormone for binding with the estrogen receptors ERα and ERβ.[2] Nonylphenol 10 was discovered to have hormone-like effects by accident because it contaminated other experiments in laboratories that were studying natural estrogens that were using polystyrene tubes.[8] Effects in pregnant women Subcutaneous injections of Nonylphenol 10 in late pregnancy causes the expression of certain placental and uterine proteins, namely CaBP-9k, which suggest it can be transferred through the placenta to the fetus. It has also been shown to have a higher potency on the first trimester placenta than the endogenous estrogen 17β-estradiol. In addition, early prenatal exposure to low doses of Nonylphenol 10 cause an increase in apoptosis (programmed cell death) in placental cells. These “low doses” ranged from 10−13-10−9 M, which is lower than what is generally found in the environment.[26] Nonylphenol 10 has also been shown to affect cytokine signaling molecule secretions in the human placenta. In vitro cell cultures of human placenta during the first trimester were treated with Nonylphenol 10, which increase the secretion of cytokines including interferon gamma, interleukin 4, and interleukin 10, and reduced the secretion of tumor necrosis factor alpha. This unbalanced cytokine profile at this part of pregnancy has been documented to result in implantation failure, pregnancy loss, and other complications.[26] Effects on metabolism Nonylphenol 10 has been shown to act as an obesity enhancing chemical or obesogen, though it has paradoxically been shown to have anti-obesity properties.[27] Growing embryos and newborns are particularly vulnerable when exposed to Nonylphenol 10 because low-doses can disrupt sensitive processes that occur during these important developmental periods.[28] Prenatal and perinatal exposure to Nonylphenol 10 has been linked with developmental abnormalities in adipose tissue and therefore in metabolic hormone synthesis and release (Merrill 2011). Specifically, by acting as an estrogen mimic, Nonylphenol 10 has generally been shown to interfere with hypothalamic appetite control.[27] The hypothalamus responds to the hormone leptin, which signals the feeling of fullness after eating, and Nonylphenol 10 has been shown to both increase and decrease eating behavior by interfering with leptin signaling in the midbrain.[27] Nonylphenol 10 has been shown mimic the action of leptin on neuropeptide Y and anorectic POMC neurons, which has an anti-obesity effect by decreasing eating behavior. This was seen when estrogen or estrogen mimics were injected into the ventromedial hypothalamus.[29] On the other hand, Nonylphenol 10 has been shown to increase food intake and have obesity enhancing properties by lowering the expression of these anorexigenic neurons in the brain.[30] Additionally, Nonylphenol 10 affects the expression of ghrelin: an enzyme produced by the stomach that stimulates appetite.[31] Ghrelin expression is positively regulated by estrogen signaling in the stomach, and it is also important in guiding the differentiation of stem cells into adipocytes (fat cells). Thus, acting as an estrogen mimic, prenatal and perinatal exposure to Nonylphenol 10 has been shown to increase appetite and encourage the body to store fat later in life.[32] Finally, long-term exposure to Nonylphenol 10 has been shown to affect insulin signaling in the liver of adult male rats.[33] Cancer Nonylphenol 10 exposure has also been associated with breast cancer.[2] It has been shown to promote the proliferation of breast cancer cells, due to its agonistic activity on ERα (estrogen receptor α) in estrogen-dependent and estrogen-independent breast cancer cells. Some argue that Nonylphenol 10's suggested estrogenic effect coupled with its widespread human exposure could potentially influence hormone-dependent breast cancer disease.[34] Human exposure and breakdown Exposure Diet seems the most significant source of exposure of Nonylphenol 10 to humans. For example, food samples were found with concentrations ranging from 0.1 to 19.4 µg/kg in a diet survey in Germany and a daily intake for an adult were calculated to be 7.5 µg/day.[35] Another study calculated a daily intake for the more exposed group of infants in the range of 0.23-0.65 µg/ kg bodyweight/ day.[36] In Taiwan, Nonylphenol 10 concentrations in food ranged from 5.8 to 235.8 µg/kg. Seafood in particular was found to have a high concentration of Nonylphenol 10.[37] One study conducted in Italian women showed that Nonylphenol 10 was one of the highest contaminants at a concentration of 32 ng/mL in breast milk when compared to other alkyl phenols, such as octylphenol, Nonylphenol 10 monoethoxylate, and two octylphenol ethoxylates. The study also found a positive correlation between fish consumption and the concentration of Nonylphenol 10 in breast milk.[37] This is a large problem because breast milk is the main source of nourishment for newborns, who are in early stages of development where hormones are very influential. Elevated levels of endocrine disruptors in breast milk have been associated with negative effects on neurological development, growth, and memory function. Drinking water does not represent a significant source of exposure in comparison to other sources such as food packing materials, cleaning products, and various skin care products. Concentrations of Nonylphenol 10 in treated drinking water varied from 85 ng/L in Spain to 15 ng/L in Germany.[2] Microgram amounts of Nonylphenol 10 have also been found in the saliva of patients with dental sealants.[34] Breakdown When humans orally ingest Nonylphenol 10, it is rapidly absorbed in the gastrointestinal tract. The metabolic pathways involved in its degradation are thought to involve glucuronide and sulfate conjugation, and the metabolites are then concentrated in fat. There is inconsistent data on bioaccumulation in humans, but Nonylphenol 10 has been shown to bioaccumulate in water-dwelling animals and birds. Nonylphenol 10 is excreted in feces and in urine.[3] Analytics Since Nonylphenol 10s are ubiquitous in different environmentally relevant matrices like food, drinking water and human tissue samples there are many possible analytical methods for their detection. Most common methods are the analysis with GC-MS. Also as special two-dimensional application with a GCxGC-ToF-MS.[38] Nevertheless, Nonylphenol 10s are also separated via HPLC technics.[39] As the branching of the nonyl sidechain plays an important role because of their varying estrogen potential different Nonylphenol 10s where synthesized and analyzed on GC-MS or GC-FID systems.[40][41][42][43] In these studies the scope was also on the enantioselective separation of different Nonylphenol 10s since biological systems are usually enantioselective. Regulation The production and use of Nonylphenol 10 and Nonylphenol 10 ethoxylates is prohibited in the European Union due to its effects on health and the environment.[2][44] In Europe, due to environmental concerns, they also have been replaced by more expensive alcohol ethoxylates, which are less problematic for the environment due to their ability to degrade more quickly than Nonylphenol 10s. The European Union has also included NP on the list of priority hazardous substances for surface water in the Water Framework Directive. They are now implementing a drastic reduction policy of NP's in surface waterways. The Environmental quality standard for NP was proposed to be 0.3 ug/l.[2] In 2013 Nonylphenol 10s were registered on the REACH candidate list. In the US, the EPA set criteria which recommends that Nonylphenol 10 concentration should not exceed 6.6 ug/l in fresh water and 1.7 ug/l in saltwater.[45] In order to do so, the EPA is supporting and encouraging a voluntary phase-out of Nonylphenol 10 in industrial laundry detergents. Similarly, the EPA is documenting proposals for a "significant new use" rule, which would require companies to contact the EPA if they decided to add Nonylphenol 10 to any new cleaning and detergent products. They also plan to do more risk assessments to ascertain the effects of Nonylphenol 10 on human health and the environment. It was suggested that Nonylphenol 10 could be added to the list of chemicals on the Toxic Substances Control Act of 1976, but this has yet to occur as of 2014.[3] In other Asian and South American countries Nonylphenol 10 is still widely available in commercial detergents, and there is little regulation.[45]
NONYLPHÉNOL 10 EO
no cas: 68412-54-4, NP 100, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols; Isononylphenol, ethoxylated Nonylphenol, branched, ethoxylated Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4) Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylphenol
NONYLPHÉNOL 100 EO
no cas: 68412-54-4, NP 12, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols; Nonylphenol, branched, ethoxylated ; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4); Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylpheno
NONYLPHÉNOL 12 EO
no cas: 68412-54-4, NP 4, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols, Nonylphenol, branched, ethoxylated, Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4) Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylphenol
NONYLPHENOL 30
Nonylphenol 30 IUPAC Name 4-nonylphenol Nonylphenol 30 InChI 1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3 Nonylphenol 30 InChI Key IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol 30 Canonical SMILES CCCCCCCCCC1=CC=C(C=C1)O Nonylphenol 30 Molecular Formula C15H24O Nonylphenol 30 CAS 104-40-5 Nonylphenol 30 Deprecated CAS 29832-11-9 Nonylphenol 30 European Community (EC) Number 203-199-4 Nonylphenol 30 DSSTox Substance ID DTXSID0028375 Nonylphenol 30 Physical Description Solid Nonylphenol 30 Color/Form Viscous, yellow liquid Nonylphenol 30 Boiling Point 317 °C Nonylphenol 30 Melting Point 42.0 °C Nonylphenol 30 Flash Point 113 °C (235 °F) - closed cup Nonylphenol 30 Solubility 3.18e-05 M Nonylphenol 30 Density 0.950 g/cu cm at 20 °C Nonylphenol 30 Vapor Pressure 8.18e-04 mmHg Nonylphenol 30 LogP 5.76 (LogP) Nonylphenol 30 Decomposition When heated to decomposition it emits acrid smoke and irritating vapors. Nonylphenol 30 Refractive Index Index of refraction: 1.513 at 20 °C Nonylphenol 30 Molecular Weight 220.35 g/mol Nonylphenol 30 XLogP3 5.9 Nonylphenol 30 Hydrogen Bond Donor Count 1 Nonylphenol 30 Hydrogen Bond Acceptor Count 1 Nonylphenol 30 Rotatable Bond Count 8 Nonylphenol 30 Exact Mass 220.182715 g/mol Nonylphenol 30 Monoisotopic Mass 220.182715 g/mol Nonylphenol 30 Topological Polar Surface Area 20.2 Ų Nonylphenol 30 Heavy Atom Count 16 Nonylphenol 30 Formal Charge 0 Nonylphenol 30 Complexity 148 Nonylphenol 30 Isotope Atom Count 0 Nonylphenol 30 Defined Atom Stereocenter Count 0 Nonylphenol 30 Undefined Atom Stereocenter Count 0 Nonylphenol 30 Defined Bond Stereocenter Count 0 Nonylphenol 30 Undefined Bond Stereocenter Count 0 Nonylphenol 30 Covalently-Bonded Unit Count 1 Nonylphenol 30 Compound Is Canonicalized Yes Nonylphenol 30 is a member of the class of phenols that is phenol which is para-substituted with a nonyl group. It has a role as an environmental contaminant.Nonylphenol 30 (4-NP) is an estrogenic endocrine active chemical that is present in detergents and is known to contaminate food and drinking water. The predominant metabolite in bile was a glucuronide conjugate of Nonylphenol 30. Other metabolites included glucuronide conjugates of ring or side chain hydroxylated Nonylphenol 30.Liver contained a low level (1.7%) of covalently bound residues. Metabolism studies using isolated trout hepatocytes produced a similar range of metabolites and a sulfate conjugate of hydroxylated Nonylphenol 30. Despite rapid metabolism and excretion, a substantial depot of parent compound remained in muscle which will have implications for the maintenance of Nonylphenol 30 residues and associated biological activity.Nonylphenol 30 (4-NP) is a well-known toxic environmental contaminant. The major objective of the present study was to identify reactive metabolites of 4-NP. Following incubations of 4-NP with NADPH- and GSH-supplemented human liver microsomes, 6 GSH conjugates, along with 19 oxidized metabolites, were detected by UPLC/Q-TOF mass spectrometry utilizing the mass defect filter method.Nonylphenol 30 has known human metabolites that include (4-Nonylphenyl) hydrogen sulfate.Nonylphenol 30 is a thick, yellow liquid. It is very slightly to insoluble in water. USE: Nonylphenol 30 is used to make lubricating oil additives, resins, plasticizers, fungicides, rubbers and plastics. These products are used in industry, agriculture and in the home. Household products containing Nonylphenol 30 include food packaging and rubber items intended for repeated use in contact with food . Nonylphenol 30 is a mixture component of nonylphenol which is present in many household maintenance products such as epoxy. Nonylphenols are being phased out of use in consumer products. EXPOSURE: Workers that use Nonylphenol 30 may breathe in vapors or have direct skin contact. The general population may be exposed by ingestion of or dermal contact with contaminated water and dermal contact with products containing this compound. Nonylphenol 30 has been detected in human breast milk, blood and urine. If Nonylphenol 30 is released to the environment, it will be very persistent. It will be broken down in air but is not expected to be broken down by sunlight. It will move slowly into air from moist soil and water surfaces. It is not expected to move through soil. It will be broken down by microorganisms and is expected to build up in fish, animals and humans. RISK: Altered function has been observed in human immune cells exposed to Nonylphenol 30 in a laboratory setting. These studies suggest that exposure to Nonylphenol 30 may increase the risk of autoimmune diseases, where the body's immune system attacks healthy cells, such as inflammatory bowel disease. However, there are no studies evaluating potential associations between Nonylphenol 30 exposure levels in humans and immune function. No additional data on the potential toxic effects of Nonylphenol 30 in humans were available. Severe eye damage was observed in laboratory animals following direct exposure. Increased immune responses to known allergens were observed in laboratory animals exposed to Nonylphenol 30 via injection, indicating that Nonylphenol 30 may aggravate allergic diseases. Data on the potential for Nonylphenol 30 to cause infertility, abortion, or birth defects were not available. However, risk factors for obesity (increases in body weight, fat mass and serum cholesterol) were observed in both first and second generation offspring of laboratory animals exposed to oral doses of Nonylphenol 30 during pregnancy only. Obesity risk factors were also observed in young laboratory animals directly exposed to Nonylphenol 30 via injection. Data on the potential for Nonylphenol 30 to cause cancer in laboratory animals were not available. The potential for Nonylphenol 30 to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC)The two commercial purity grades of Nonylphenol 30 are a technical grade which is composed of 10-12% 2-nonylphenol, 85-90% Nonylphenol 30, and up to 5% 2,4-dinonylphenol, and a high purity grade which contains 5% maximum 2-nonylphenol, 95% minimum Nonylphenol 30, and only a trace of 2,4-dinonylphenol.The pressurized liquid extraction (PLE) of Nonylphenol 30 (4-NP) with methanol (100 degrees C and 100 atm) from river sediments was compared with methanolic Soxhlet extraction, the standard method for the sediment analysis. The PLE method showed a precision (average RSD ranged from 6 to 33%) and an accuracy (average recovery 85 and 87% for 4-NP and 4-NPE, respectively) comparable to those of Soxhlet. The extraction was performed on river sediments and no organic carbon content influence was found. The comparative study presented in this paper demonstrates that PLE is an alternative suitable extraction method for Nonylphenol 30 and Nonylphenol 30 ethoxylate determination in sediments.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Nonylphenol 30 is included on this list.The independent and combined effects of 2 chemicals, diazinon (an insecticide) and Nonylphenol 30 (a detergent metabolite), on the swimming behavior of the freshwater crustacean Daphnia pulex were examined. Cumulative distance and change in direction were measured repeatedly via optical tracking over 90 min. Exposure to low concentrations of diazinon (0.125-2 uM) or Nonylphenol 30 (0.25-4 uM) elicited significant concentration- and time-dependent effects on swimming behavior. Exposure to 0.5 uM Nonylphenol 30 alone did not significantly alter mean cumulative distance but did elicit a small, significant increase in mean angle, the measure of change in direction. When 0.5 uM Nonylphenol 30 was used in combination with diazinon (0.125-0.5 uM), it augmented the adverse impact of diazinon on the swimming behavior of Daphnia. Additionally, enhanced sensitivity to diazinon was observed in animals exposed to treated wastewater effluent for 24 hr prior to a diazinon challenge. The present experiments demonstrate that exposure to Nonylphenol 30 and complex chemical mixtures (e.g., treated wastewater) can enhance the toxicity of exposure to the insecticide diazinon.Nonylphenol 30 is a widely diffused and stable environmental contaminant, originating from the degradation of alkyl phenol ethoxylates, common surfactants employed in several industrial applications. Due to its hydrophobic nature, Nonylphenol 30 can easily accumulate in living organisms, including humans, where it displays a wide range of toxic effects. Since the gastrointestinal tract represents the main route by which Nonylphenol 30 enters the body, the intestine may be one of the first organs to be damaged by chronic exposure to this pollutant through the diet. In the present study, we investigated the effects of Nonylphenol 30 on a human intestinal epithelial cell line (Caco-2 cells). We demonstrated that Nonylphenol 30 was cytotoxic to cells, as revealed by a decrease of the cell number and the decrement of mitochondrial functionality after 24 hr of treatment. Nonylphenol 30 also reduced the number of cells entering into S-phase and interfered with epidermal growth factor signaling, with consequent negative effects on cell survival. In addition, Nonylphenol 30 induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1). Together, these findings support the hypothesis that prolonged exposure to Nonylphenol 30 through the diet may lead to local damage at the level of intestinal mucosa, with potentially negative consequences for intestinal homeostasis and functionality.Exogenous substances altering the function of the endocrine system and exhibiting adverse health effects on the organism are defined as endocrine disruptors. Nonylphenol is one of the most abundant alkylphenol ethoxylate derivatives, being detected in food products. Diverse studies have classified nonylphenol as hazardous to the health, especially to male reproduction. This in vitro study aimed to examine the effects of Nonylphenol 30 on androstenedione and testosterone production as well as on the viability of Leydig cells of NMRI mice. The cells were cultured for 44 h with addition of 0.04; 0.2; 1.0; 2.5 and 5.0 ug/mL of Nonylphenol 30 and compared to the control. Quantification of testosterone and androstenedione directly from aliquots of the medium was performed by enzyme-linked immunosorbent assay. Cell viability was measured by the metabolic activity assay for mitochondrial functional activity. Androstenedione production significantly (P < 0.001) increased with 1.0; 2.5 and 5.0 ug/mL Nonylphenol 30. Although cAMP-stimulated testosterone production was not significantly affected by Nonylphenol 30, a tendency to attenuate the level of testosterone in the Leydig cells treated with 2.5 and 5.0 ug/mL Nonylphenol 30 was observed. The viability of mouse Leydig cells was slightly increased at the lowest doses of Nonylphenol 30 (0.04 and 0.2 ug/mL). We also observed an increase at higher concentrations of the substance (1.0; 2.5 and 5.0 ug/mL), but this increase was not significant. Further investigations are required to establish the biological significance and possible reproductive implications.
NONYLPHÉNOL 4 EO
no cas: 68412-54-4, NP 6, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols, Nonylphenol, branched, ethoxylated Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4) Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylphenol
NONYLPHENOL 6
Nonylphenol 6 IUPAC Name 4-nonylphenol Nonylphenol 6 InChI 1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3 Nonylphenol 6 InChI Key IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol 6 Canonical SMILES CCCCCCCCCC1=CC=C(C=C1)O Nonylphenol 6 Molecular Formula C15H24O Nonylphenol 6 CAS 104-40-5 Nonylphenol 6 Deprecated CAS 29832-11-9 Nonylphenol 6 European Community (EC) Number 203-199-4 Nonylphenol 6 DSSTox Substance ID DTXSID0028375 Nonylphenol 6 Physical Description Solid Nonylphenol 6 Color/Form Viscous, yellow liquid Nonylphenol 6 Boiling Point 317 °C Nonylphenol 6 Melting Point 42.0 °C Nonylphenol 6 Flash Point 113 °C (235 °F) - closed cup Nonylphenol 6 Solubility 3.18e-05 M Nonylphenol 6 Density 0.950 g/cu cm at 20 °C Nonylphenol 6 Vapor Pressure 8.18e-04 mmHg Nonylphenol 6 LogP 5.76 (LogP) Nonylphenol 6 Decomposition When heated to decomposition it emits acrid smoke and irritating vapors. Nonylphenol 6 Refractive Index Index of refraction: 1.513 at 20 °C Nonylphenol 6 Molecular Weight 220.35 g/mol Nonylphenol 6 XLogP3 5.9 Nonylphenol 6 Hydrogen Bond Donor Count 1 Nonylphenol 6 Hydrogen Bond Acceptor Count 1 Nonylphenol 6 Rotatable Bond Count 8 Nonylphenol 6 Exact Mass 220.182715 g/mol Nonylphenol 6 Monoisotopic Mass 220.182715 g/mol Nonylphenol 6 Topological Polar Surface Area 20.2 Ų Nonylphenol 6 Heavy Atom Count 16 Nonylphenol 6 Formal Charge 0 Nonylphenol 6 Complexity 148 Nonylphenol 6 Isotope Atom Count 0 Nonylphenol 6 Defined Atom Stereocenter Count 0 Nonylphenol 6 Undefined Atom Stereocenter Count 0 Nonylphenol 6 Defined Bond Stereocenter Count 0 Nonylphenol 6 Undefined Bond Stereocenter Count 0 Nonylphenol 6 Covalently-Bonded Unit Count 1 Nonylphenol 6 Compound Is Canonicalized Yes Nonylphenol 6 is a member of the class of phenols that is phenol which is para-substituted with a nonyl group. It has a role as an environmental contaminant.Nonylphenol 6 (4-NP) is an estrogenic endocrine active chemical that is present in detergents and is known to contaminate food and drinking water. The predominant metabolite in bile was a glucuronide conjugate of Nonylphenol 6. Other metabolites included glucuronide conjugates of ring or side chain hydroxylated Nonylphenol 6.Liver contained a low level (1.7%) of covalently bound residues. Metabolism studies using isolated trout hepatocytes produced a similar range of metabolites and a sulfate conjugate of hydroxylated Nonylphenol 6. Despite rapid metabolism and excretion, a substantial depot of parent compound remained in muscle which will have implications for the maintenance of Nonylphenol 6 residues and associated biological activity.Nonylphenol 6 (4-NP) is a well-known toxic environmental contaminant. The major objective of the present study was to identify reactive metabolites of 4-NP. Following incubations of 4-NP with NADPH- and GSH-supplemented human liver microsomes, 6 GSH conjugates, along with 19 oxidized metabolites, were detected by UPLC/Q-TOF mass spectrometry utilizing the mass defect filter method.Nonylphenol 6 has known human metabolites that include (4-Nonylphenyl) hydrogen sulfate.Nonylphenol 6 is a thick, yellow liquid. It is very slightly to insoluble in water. USE: Nonylphenol 6 is used to make lubricating oil additives, resins, plasticizers, fungicides, rubbers and plastics. These products are used in industry, agriculture and in the home. Household products containing Nonylphenol 6 include food packaging and rubber items intended for repeated use in contact with food . Nonylphenol 6 is a mixture component of nonylphenol which is present in many household maintenance products such as epoxy. Nonylphenols are being phased out of use in consumer products. EXPOSURE: Workers that use Nonylphenol 6 may breathe in vapors or have direct skin contact. The general population may be exposed by ingestion of or dermal contact with contaminated water and dermal contact with products containing this compound. Nonylphenol 6 has been detected in human breast milk, blood and urine. If Nonylphenol 6 is released to the environment, it will be very persistent. It will be broken down in air but is not expected to be broken down by sunlight. It will move slowly into air from moist soil and water surfaces. It is not expected to move through soil. It will be broken down by microorganisms and is expected to build up in fish, animals and humans. RISK: Altered function has been observed in human immune cells exposed to Nonylphenol 6 in a laboratory setting. These studies suggest that exposure to Nonylphenol 6 may increase the risk of autoimmune diseases, where the body's immune system attacks healthy cells, such as inflammatory bowel disease. However, there are no studies evaluating potential associations between Nonylphenol 6 exposure levels in humans and immune function. No additional data on the potential toxic effects of Nonylphenol 6 in humans were available. Severe eye damage was observed in laboratory animals following direct exposure. Increased immune responses to known allergens were observed in laboratory animals exposed to Nonylphenol 6 via injection, indicating that Nonylphenol 6 may aggravate allergic diseases. Data on the potential for Nonylphenol 6 to cause infertility, abortion, or birth defects were not available. However, risk factors for obesity (increases in body weight, fat mass and serum cholesterol) were observed in both first and second generation offspring of laboratory animals exposed to oral doses of Nonylphenol 6 during pregnancy only. Obesity risk factors were also observed in young laboratory animals directly exposed to Nonylphenol 6 via injection. Data on the potential for Nonylphenol 6 to cause cancer in laboratory animals were not available. The potential for Nonylphenol 6 to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC)The two commercial purity grades of Nonylphenol 6 are a technical grade which is composed of 10-12% 2-nonylphenol, 85-90% Nonylphenol 6, and up to 5% 2,4-dinonylphenol, and a high purity grade which contains 5% maximum 2-nonylphenol, 95% minimum Nonylphenol 6, and only a trace of 2,4-dinonylphenol.The pressurized liquid extraction (PLE) of Nonylphenol 6 (4-NP) with methanol (100 degrees C and 100 atm) from river sediments was compared with methanolic Soxhlet extraction, the standard method for the sediment analysis. The PLE method showed a precision (average RSD ranged from 6 to 33%) and an accuracy (average recovery 85 and 87% for 4-NP and 4-NPE, respectively) comparable to those of Soxhlet. The extraction was performed on river sediments and no organic carbon content influence was found. The comparative study presented in this paper demonstrates that PLE is an alternative suitable extraction method for Nonylphenol 6 and Nonylphenol 6 ethoxylate determination in sediments.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Nonylphenol 6 is included on this list.The independent and combined effects of 2 chemicals, diazinon (an insecticide) and Nonylphenol 6 (a detergent metabolite), on the swimming behavior of the freshwater crustacean Daphnia pulex were examined. Cumulative distance and change in direction were measured repeatedly via optical tracking over 90 min. Exposure to low concentrations of diazinon (0.125-2 uM) or Nonylphenol 6 (0.25-4 uM) elicited significant concentration- and time-dependent effects on swimming behavior. Exposure to 0.5 uM Nonylphenol 6 alone did not significantly alter mean cumulative distance but did elicit a small, significant increase in mean angle, the measure of change in direction. When 0.5 uM Nonylphenol 6 was used in combination with diazinon (0.125-0.5 uM), it augmented the adverse impact of diazinon on the swimming behavior of Daphnia. Additionally, enhanced sensitivity to diazinon was observed in animals exposed to treated wastewater effluent for 24 hr prior to a diazinon challenge. The present experiments demonstrate that exposure to Nonylphenol 6 and complex chemical mixtures (e.g., treated wastewater) can enhance the toxicity of exposure to the insecticide diazinon.Nonylphenol 6 is a widely diffused and stable environmental contaminant, originating from the degradation of alkyl phenol ethoxylates, common surfactants employed in several industrial applications. Due to its hydrophobic nature, Nonylphenol 6 can easily accumulate in living organisms, including humans, where it displays a wide range of toxic effects. Since the gastrointestinal tract represents the main route by which Nonylphenol 6 enters the body, the intestine may be one of the first organs to be damaged by chronic exposure to this pollutant through the diet. In the present study, we investigated the effects of Nonylphenol 6 on a human intestinal epithelial cell line (Caco-2 cells). We demonstrated that Nonylphenol 6 was cytotoxic to cells, as revealed by a decrease of the cell number and the decrement of mitochondrial functionality after 24 hr of treatment. Nonylphenol 6 also reduced the number of cells entering into S-phase and interfered with epidermal growth factor signaling, with consequent negative effects on cell survival. In addition, Nonylphenol 6 induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1). Together, these findings support the hypothesis that prolonged exposure to Nonylphenol 6 through the diet may lead to local damage at the level of intestinal mucosa, with potentially negative consequences for intestinal homeostasis and functionality.Exogenous substances altering the function of the endocrine system and exhibiting adverse health effects on the organism are defined as endocrine disruptors. Nonylphenol is one of the most abundant alkylphenol ethoxylate derivatives, being detected in food products. Diverse studies have classified nonylphenol as hazardous to the health, especially to male reproduction. This in vitro study aimed to examine the effects of Nonylphenol 6 on androstenedione and testosterone production as well as on the viability of Leydig cells of NMRI mice. The cells were cultured for 44 h with addition of 0.04; 0.2; 1.0; 2.5 and 5.0 ug/mL of Nonylphenol 6 and compared to the control. Quantification of testosterone and androstenedione directly from aliquots of the medium was performed by enzyme-linked immunosorbent assay. Cell viability was measured by the metabolic activity assay for mitochondrial functional activity. Androstenedione production significantly (P < 0.001) increased with 1.0; 2.5 and 5.0 ug/mL Nonylphenol 6. Although cAMP-stimulated testosterone production was not significantly affected by Nonylphenol 6, a tendency to attenuate the level of testosterone in the Leydig cells treated with 2.5 and 5.0 ug/mL Nonylphenol 6 was observed. The viability of mouse Leydig cells was slightly increased at the lowest doses of Nonylphenol 6 (0.04 and 0.2 ug/mL). We also observed an increase at higher concentrations of the substance (1.0; 2.5 and 5.0 ug/mL), but this increase was not significant. Further investigations are required to establish the biological significance and possible reproductive implications.
NONYLPHÉNOL 6 EO
no cas: 68412-54-4, NP 7, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols, Nonylphenol, branched, ethoxylated Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4) Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylphenol
NONYLPHÉNOL 7 EO
no cas: 68412-54-4, NP 8, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols, Nonylphenol, branched, ethoxylated; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4) Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylphenol
NONYLPHENOL 8
Nonylphenol 8 IUPAC Name 4-nonylphenol Nonylphenol 8 InChI 1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3 Nonylphenol 8 InChI Key IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol 8 Canonical SMILES CCCCCCCCCC1=CC=C(C=C1)O Nonylphenol 8 Molecular Formula C15H24O Nonylphenol 8 CAS 104-40-5 Nonylphenol 8 Deprecated CAS 29832-11-9 Nonylphenol 8 European Community (EC) Number 203-199-4 Nonylphenol 8 DSSTox Substance ID DTXSID0028375 Nonylphenol 8 Physical Description Solid Nonylphenol 8 Color/Form Viscous, yellow liquid Nonylphenol 8 Boiling Point 317 °C Nonylphenol 8 Melting Point 42.0 °C Nonylphenol 8 Flash Point 113 °C (235 °F) - closed cup Nonylphenol 8 Solubility 3.18e-05 M Nonylphenol 8 Density 0.950 g/cu cm at 20 °C Nonylphenol 8 Vapor Pressure 8.18e-04 mmHg Nonylphenol 8 LogP 5.76 (LogP) Nonylphenol 8 Decomposition When heated to decomposition it emits acrid smoke and irritating vapors. Nonylphenol 8 Refractive Index Index of refraction: 1.513 at 20 °C Nonylphenol 8 Molecular Weight 220.35 g/mol Nonylphenol 8 XLogP3 5.9 Nonylphenol 8 Hydrogen Bond Donor Count 1 Nonylphenol 8 Hydrogen Bond Acceptor Count 1 Nonylphenol 8 Rotatable Bond Count 8 Nonylphenol 8 Exact Mass 220.182715 g/mol Nonylphenol 8 Monoisotopic Mass 220.182715 g/mol Nonylphenol 8 Topological Polar Surface Area 20.2 Ų Nonylphenol 8 Heavy Atom Count 16 Nonylphenol 8 Formal Charge 0 Nonylphenol 8 Complexity 148 Nonylphenol 8 Isotope Atom Count 0 Nonylphenol 8 Defined Atom Stereocenter Count 0 Nonylphenol 8 Undefined Atom Stereocenter Count 0 Nonylphenol 8 Defined Bond Stereocenter Count 0 Nonylphenol 8 Undefined Bond Stereocenter Count 0 Nonylphenol 8 Covalently-Bonded Unit Count 1 Nonylphenol 8 Compound Is Canonicalized Yes Nonylphenol 8 is a member of the class of phenols that is phenol which is para-substituted with a nonyl group. It has a role as an environmental contaminant.Nonylphenol 8 (4-NP) is an estrogenic endocrine active chemical that is present in detergents and is known to contaminate food and drinking water. The predominant metabolite in bile was a glucuronide conjugate of Nonylphenol 8. Other metabolites included glucuronide conjugates of ring or side chain hydroxylated Nonylphenol 8.Liver contained a low level (1.7%) of covalently bound residues. Metabolism studies using isolated trout hepatocytes produced a similar range of metabolites and a sulfate conjugate of hydroxylated Nonylphenol 8. Despite rapid metabolism and excretion, a substantial depot of parent compound remained in muscle which will have implications for the maintenance of Nonylphenol 8 residues and associated biological activity.Nonylphenol 8 (4-NP) is a well-known toxic environmental contaminant. The major objective of the present study was to identify reactive metabolites of 4-NP. Following incubations of 4-NP with NADPH- and GSH-supplemented human liver microsomes, 6 GSH conjugates, along with 19 oxidized metabolites, were detected by UPLC/Q-TOF mass spectrometry utilizing the mass defect filter method.Nonylphenol 8 has known human metabolites that include (4-Nonylphenyl) hydrogen sulfate.Nonylphenol 8 is a thick, yellow liquid. It is very slightly to insoluble in water. USE: Nonylphenol 8 is used to make lubricating oil additives, resins, plasticizers, fungicides, rubbers and plastics. These products are used in industry, agriculture and in the home. Household products containing Nonylphenol 8 include food packaging and rubber items intended for repeated use in contact with food . Nonylphenol 8 is a mixture component of nonylphenol which is present in many household maintenance products such as epoxy. Nonylphenols are being phased out of use in consumer products. EXPOSURE: Workers that use Nonylphenol 8 may breathe in vapors or have direct skin contact. The general population may be exposed by ingestion of or dermal contact with contaminated water and dermal contact with products containing this compound. Nonylphenol 8 has been detected in human breast milk, blood and urine. If Nonylphenol 8 is released to the environment, it will be very persistent. It will be broken down in air but is not expected to be broken down by sunlight. It will move slowly into air from moist soil and water surfaces. It is not expected to move through soil. It will be broken down by microorganisms and is expected to build up in fish, animals and humans. RISK: Altered function has been observed in human immune cells exposed to Nonylphenol 8 in a laboratory setting. These studies suggest that exposure to Nonylphenol 8 may increase the risk of autoimmune diseases, where the body's immune system attacks healthy cells, such as inflammatory bowel disease. However, there are no studies evaluating potential associations between Nonylphenol 8 exposure levels in humans and immune function. No additional data on the potential toxic effects of Nonylphenol 8 in humans were available. Severe eye damage was observed in laboratory animals following direct exposure. Increased immune responses to known allergens were observed in laboratory animals exposed to Nonylphenol 8 via injection, indicating that Nonylphenol 8 may aggravate allergic diseases. Data on the potential for Nonylphenol 8 to cause infertility, abortion, or birth defects were not available. However, risk factors for obesity (increases in body weight, fat mass and serum cholesterol) were observed in both first and second generation offspring of laboratory animals exposed to oral doses of Nonylphenol 8 during pregnancy only. Obesity risk factors were also observed in young laboratory animals directly exposed to Nonylphenol 8 via injection. Data on the potential for Nonylphenol 8 to cause cancer in laboratory animals were not available. The potential for Nonylphenol 8 to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC)The two commercial purity grades of Nonylphenol 8 are a technical grade which is composed of 10-12% 2-nonylphenol, 85-90% Nonylphenol 8, and up to 5% 2,4-dinonylphenol, and a high purity grade which contains 5% maximum 2-nonylphenol, 95% minimum Nonylphenol 8, and only a trace of 2,4-dinonylphenol.The pressurized liquid extraction (PLE) of Nonylphenol 8 (4-NP) with methanol (100 degrees C and 100 atm) from river sediments was compared with methanolic Soxhlet extraction, the standard method for the sediment analysis. The PLE method showed a precision (average RSD ranged from 6 to 33%) and an accuracy (average recovery 85 and 87% for 4-NP and 4-NPE, respectively) comparable to those of Soxhlet. The extraction was performed on river sediments and no organic carbon content influence was found. The comparative study presented in this paper demonstrates that PLE is an alternative suitable extraction method for Nonylphenol 8 and Nonylphenol 8 ethoxylate determination in sediments.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Nonylphenol 8 is included on this list.The independent and combined effects of 2 chemicals, diazinon (an insecticide) and Nonylphenol 8 (a detergent metabolite), on the swimming behavior of the freshwater crustacean Daphnia pulex were examined. Cumulative distance and change in direction were measured repeatedly via optical tracking over 90 min. Exposure to low concentrations of diazinon (0.125-2 uM) or Nonylphenol 8 (0.25-4 uM) elicited significant concentration- and time-dependent effects on swimming behavior. Exposure to 0.5 uM Nonylphenol 8 alone did not significantly alter mean cumulative distance but did elicit a small, significant increase in mean angle, the measure of change in direction. When 0.5 uM Nonylphenol 8 was used in combination with diazinon (0.125-0.5 uM), it augmented the adverse impact of diazinon on the swimming behavior of Daphnia. Additionally, enhanced sensitivity to diazinon was observed in animals exposed to treated wastewater effluent for 24 hr prior to a diazinon challenge. The present experiments demonstrate that exposure to Nonylphenol 8 and complex chemical mixtures (e.g., treated wastewater) can enhance the toxicity of exposure to the insecticide diazinon.Nonylphenol 8 is a widely diffused and stable environmental contaminant, originating from the degradation of alkyl phenol ethoxylates, common surfactants employed in several industrial applications. Due to its hydrophobic nature, Nonylphenol 8 can easily accumulate in living organisms, including humans, where it displays a wide range of toxic effects. Since the gastrointestinal tract represents the main route by which Nonylphenol 8 enters the body, the intestine may be one of the first organs to be damaged by chronic exposure to this pollutant through the diet. In the present study, we investigated the effects of Nonylphenol 8 on a human intestinal epithelial cell line (Caco-2 cells). We demonstrated that Nonylphenol 8 was cytotoxic to cells, as revealed by a decrease of the cell number and the decrement of mitochondrial functionality after 24 hr of treatment. Nonylphenol 8 also reduced the number of cells entering into S-phase and interfered with epidermal growth factor signaling, with consequent negative effects on cell survival. In addition, Nonylphenol 8 induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1). Together, these findings support the hypothesis that prolonged exposure to Nonylphenol 8 through the diet may lead to local damage at the level of intestinal mucosa, with potentially negative consequences for intestinal homeostasis and functionality.Exogenous substances altering the function of the endocrine system and exhibiting adverse health effects on the organism are defined as endocrine disruptors. Nonylphenol is one of the most abundant alkylphenol ethoxylate derivatives, being detected in food products. Diverse studies have classified nonylphenol as hazardous to the health, especially to male reproduction. This in vitro study aimed to examine the effects of Nonylphenol 8 on androstenedione and testosterone production as well as on the viability of Leydig cells of NMRI mice. The cells were cultured for 44 h with addition of 0.04; 0.2; 1.0; 2.5 and 5.0 ug/mL of Nonylphenol 8 and compared to the control. Quantification of testosterone and androstenedione directly from aliquots of the medium was performed by enzyme-linked immunosorbent assay. Cell viability was measured by the metabolic activity assay for mitochondrial functional activity. Androstenedione production significantly (P < 0.001) increased with 1.0; 2.5 and 5.0 ug/mL Nonylphenol 8. Although cAMP-stimulated testosterone production was not significantly affected by Nonylphenol 8, a tendency to attenuate the level of testosterone in the Leydig cells treated with 2.5 and 5.0 ug/mL Nonylphenol 8 was observed. The viability of mouse Leydig cells was slightly increased at the lowest doses of Nonylphenol 8 (0.04 and 0.2 ug/mL). We also observed an increase at higher concentrations of the substance (1.0; 2.5 and 5.0 ug/mL), but this increase was not significant. Further investigations are required to establish the biological significance and possible reproductive implications.
NONYLPHÉNOL 8 EO
no cas: 68412-54-4, NP 9, Polyoxyethylene, Nonylphenyl Ether, Polyethylene Mono(nonylphenyl)ether Glycols, Nonylphenol, branched, ethoxylated Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched (CAS[#] 68412-54-4), Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), .alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; (OLIGOMER) Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); 1-ethoxy-4-(7-methyloctyl)benzene; 2-[2-(4-nonylphenoxy)ethoxy]ethanol; 2-{2-[4-(2,4,5-trimethylhexan-3-yl)phenoxy]polyethoxy}ethanol; Alkylphenol ethoxylate; Branched alkylphenol ethoxylate; BRANCHED-NONYLPHENOL, ETHOXYLATED (R53); Ethoxylated Nonylphenol; Ethoxylated nonylphenol, branched; Ethoxyliertes Nonylphenol; Nonidet P40; Nonoxynol-8; Nonyl phenol ethoxylate; nonyl phenol, branched, ethoxylated; nonylphenol (polyethyleneoxy) ethanol; NONYLPHENOL BRANCHED POLYETHOXYLATE; Nonylphenol, branched, ethoxylated (> 1 < 2.5 mol EO); Nonylphenol, branched, ethoxylated (NPEO); Nonylphenol, branched, ethoxylated (polymer); Nonylphenol, branched, ethoxylated more than 1 and less 2.5 mol EO; Nonylphenoxy poly(ethyleneoxy)ethanol, branched; Nonylphenoxypoly(ethyleneoxy) ethanol; Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega- hydroxy-; Poly(oxy-1,2-ethanediyl), .α.-(nonylphenyl)-.ω.-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy-, branched; Poly(oxy-1,2-ethanediyl), alpha.-(nonylphenyl)-.omega.-hydroxy-, branched; Polyoxyethylene (9) nonylphenylether, branched; SURFACTANT; s: (C9) Branched alkylphenol, ethoxylate: ABEX NP 650 S; Antarox CO 210; 1,5-EO; ANTAROX CO 997; 100-EO; Antarox-CO-850; 20-EO; APEO C9 branched + 20EO; 20-EO; APEO C9 branched + 6EO; 6-EO; APEO C9 branched + nEO; n-EO; APEO C9 branched+ 9-10EO; 9-10-EO; Berol 02; 6-EO; 100% Active Matter; active substance; Berol 09; 10-EO; 100% Active Matter; active substance; Berol 267; 8-EO; Berol 268; Berol 26; 4-EO; Berol Wasc; 9-10-EO; 95% Active Matter; active substance; Branched-nonylphenol, ethoxylate; Ethylan TU; 100% Active Matter; active substance; i-Nonylphenol + 20 EO; 20-EO; 99,7% Active Matter; active substance;Nonylphenol ether branched with EO; Nonylphenolether verzweigt mit EO; Nonylphenoxydiglycol; Nonylphenoxypolyethoxy-Ethanol (branched ethoxylated nonylphenol);Phenol, nonyl-, branched, et-hoxylated; Phenol, nonyl-, verzweigt, ethoxyliert; Poly(oxy-1,2-ethandiyl), α-(nonylphenyl)-ω-hydroxy-, verzweigt; Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched; Polyethylene glycol mono(branched nonylphenyl) ether; Polyoxyethylene branched-C9-alkylphenol
NONYLPHÉNOL 9 EO
SYNONYMS 1-Hydroxypropane;1-Propanol;Ethylcarbinol;n-Propanol;N-PROPYL ALCOHOL;NSC 30300;Optal;Osmosol extra;Propan-1-ol;propane-1-ol;PROPANOL;Propyl alcohol CAS NO:71-23-8
NONYLPHENOL ETHOXYLATES (NPE)
DESCRIPTION:

Nonylphenol Ethoxylates (NPE) also known as nonylphenols and nonylphenol ethoxylates, are nonionic surfactants, or detergent-like substances, with uses that lead to widespread release into aquatic environments.
Nonylphenol Ethoxylates (NPE) is highly toxic to aquatic life.
Nonylphenol Ethoxylates (NPE) is a non-ionic and surface-active chemical raw material.


CAS: 25154-52-3
CAS Name: poly ethylene glycol isononylphenol ether.


Nonylphenol Ethoxylates (NPE) is non-ionic surfactants that used to be widely used in detergents and formulations.
Nonylphenol Ethoxylates (NPE) is persistent in the aquatic environment, moderately bioaccumulative, and extremely toxic to aquatic organisms.

Nonylphenol Ethoxylates (NPE) are used in a wide variety of industrial applications and consumer products.
NPEs, though less toxic than NP, are also highly toxic to aquatic organisms, and in the environment degrade to more environmentally persistent NP.


Nonylphenol Ethoxylates (NPE) has high cleaning power.
Nonylphenol Ethoxylates (NPE) is an industrial agent for detergent and other cleaning materials.

Nonylphenol Ethoxylates (NPE) performs in neutral cleaners.
Nonylphenol Ethoxylates (NPE) is usually used in surface actives together with distributing and complexing agents.


Nonylphenol Ethoxylates (NPE) is produced in large volumes, with uses that lead to widespread release to the aquatic environment.


Nonylphenol Ethoxylates (NPE) is common components used in a wide variety of industrial applications, from dust control agents to laundry detergents.
In the dairy industry, Nonylphenol Ethoxylates (NPE) can be found in teat disinfectants, udder washes, milking machine detergents, and commercial laundry products.

Nonylphenol Ethoxylates (NPE) is principally used as surfactants, to help liquid solutions spread or cling to other materials and surfaces.
NPEs are especially common in iodine-based products because they are an effective complexing agent, helping to keep the other components in suspension and stable throughout the product’s shelf life.


Nonylphenol Ethoxylates (NPE) are nonionic surfactants composed of ethylene oxide and Nonylphenol.
Nonylphenol Ethoxylates vary in physical appearance from clear or slightly hazy, colorless liquids to white solids, depending upon the level of ethoxylation.

Nonylphenol Ethoxylates up to 6 (NP 6) moles are water dispersible.
The high-mole ethoxylates greater than 7 moles & above (usually NP 8 & NP 9) usually are soluble in water & also soluble in most polar solvents.
In general, with increase in the ethylene oxide chain attached to Nonylphenol hydrophobe increases the HLB value (water solubility), pour point, cloud point, density, viscosity, and flash point of the ethoxylate.

Nonylphenol Ethoxylates are widely used as excellent emulsion stabilizer.
Nonylphenol Ethoxylate has Good Solubility in presence of electrolytes & caustic.
Nonylphenol Ethoxylates has High HLB (Hydrophilic–lipophilic balance) emulsifier and dispersant
Common Nonylphenol Ethoxylates NPE comes in NP 4, NP 6, NP 8, NP 9, NP 10, NP 12 and NP 15.


Nonylphenol Ethoxylates (NPEs) comprise a category of surfactants widely used in industrial cleaning products, processes, agricultural formulations and paints.
The NPE reaction product is produced by combining Nonylphenol with Ethylene Oxide.
The ratio of Ethylene Oxide to Nonylphenol determines the molecular weight of the product and the length of the molecule produced.


Nonylphenol ethoxylate (NPE) is a clear liquid substance based on the components nonylphenol and ethylene oxide.

Nonylphenol ethoxylate (NPE) has multiple applications: With brand name of Helmol, we can provide NPE 2 to NPE 50 respectively with main applications in agriculture emulsion, industrial detergent, industrial intermediate, metal working, leather and textile.





APPLICATIONS OF NONYLPHENOL ETHOXYLATE:
Nonylphenol Ethoxylate is used in Industrial and institutional cleaners
Nonylphenol Ethoxylate is used in Agricultural chemicals
Nonylphenol Ethoxylate is used in Textile and leather processing.

Nonylphenol Ethoxylate is used in Ether sulfates and ether carboxylates
Nonylphenol Ethoxylate is used in Cosmetics



USES OF NONYLPHENOL ETHOXYLATES (NPE):
Nonylphenol Ethoxylates (NPE) which is produced in large volumes, are used for industrial processes and in consumer laundry detergents, personal hygiene, automotive, latex paints, and lawn care products.

Nonylphenol Ethoxylates (NPE) is important in the production of laundry detergents.
Nonylphenol Ethoxylates (NPE) is used in the industries of textile and leather.
Nonylphenol Ethoxylates (NPE) is used in the metal industry.

Nonylphenol Ethoxylates (NPE) is used in the paper industry.
Nonylphenol Ethoxylates (NPE) is used to increase the efficiency in oil pools.


Nonylphenol ethoxylates (NPEs) have many uses, primarily as surfactants in detergent formulations, both industrial and domestic.
NPEs are no longer used in the UK in domestic detergents, although, due to their suitability for liquid detergents, their domestic use has increased in the USA.
NPEs are also used as wetting agents and as dispersants or emulsifiers in some p e s t i c i d e formulations.

The bulk of NPEs used reach the water environment via the foul sewer system with an estimated 37% reaching the wider aquatic environment undegraded, 46% reaching the soil via sludge spreading on agricultural land and 17% degraded or destroyed.
NPE production accounts for 80% of global production of alkylphenol ethoxylates (APE) with octylphenol polyethoxylates making up most of the remaining 20%.


Nonylphenol Ethoxylates (NPEs) are a large class of common ingredients found in many chemical formulations used to produce apparel and footwear materials.
They are widely used as surfactants or emulsifiers in detergents, scouring agents, dye-dispersing agents, printing pastes, spinning oils and wetting agents.

Examples of NPEO use in the garment supply chain include:
● Industrial laundry detergent
● Scouring agents (e.g., wool and leather)
● Wetting agents
● Softeners
● Spinning oils (yarn and fabric)
● Emulsifier/dispersing agents for dyes and prints
● Dyes and pigment preparations
● Facility cleaning products



SAFETY INFORMATION ABOUT NONYLPHENOL ETHOXYLATES (NPE):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



Norfloxacin
SYNONYMS Noroxin;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Norfloxacino; Norfloxacine; cas no:70458-96-7
NORPACE
Norpace is an organoammonium phosphate.
Norpace belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
Norpace is available in both oral and intravenous forms and has a low degree of toxicity.

CAS Number: 3737-09-5
Formula: C21H29N3O
Molar mass: 339.483 g·mol−1

Norpace is an antiarrhythmic chemical used in the treatment of ventricular tachycardia.
Norpace is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent.

Norpace has a negative inotropic effect on the ventricular myocardium and significantly reduces contractility.
Norpace also has an anticholinergic effect on the heart, which is responsible for many negative side effects.
Norpace is available in both oral and intravenous forms and has a low degree of toxicity.

Norpace is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.
Norpace is used at industrial sites and in manufacturing.

Norpace is an organoammonium phosphate.

Norpace is a class Ia antiarrhythmic agent with cardiac depressant properties.
Norpace exerts Norpace actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential.

This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues.
Norpace prolongs the QT interval and causes a widening of the QRS complex.

Norpace also possesses some anticholinergic and local anaesthetic properties.
Norpace is used in the treatment of supraventricular tachycardia.

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine.
Norpace also possesses some anticholinergic and local anesthetic properties.

Norpace belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
An irregular heartbeat is a condition in which your heart beats irregularly, too fast, or too slow.
Norpace helps slow the heart rate and prevent arrhythmias (abnormal heart rhythms).

Norpace sulphate contains Norpace, ie anti-arrhythmic agents.
Norpace helps bring irregular heartbeats to a normal rhythm by blocking certain electrical signals in the heart.
Irregular heartbeat treatment reduces the risk of blood clots, heart attack or stroke.

Norpace should be taken as prescribed by the doctor.
Your doctor may monitor EKGs and blood pressure during treatment to monitor your dose.

Some people may experience common side effects such as blurred or double vision, stomach pain, little or no urination, and low blood sugar.
Most of these side effects of Norpace do not require medical attention and will gradually improve over time.
However, if the side effects persist, please consult your doctor.

Please tell your doctor if you are known to be allergic to Norpace or any other medicines.
Norpace is not recommended for use in children.
Pregnant or breastfeeding women are advised to consult a doctor before taking Norpace.

Before taking Norpace, tell your doctor if you have kidney or liver disease, enlarged prostate, glaucoma (increased eye pressure) or low potassium levels in the blood (hypokalaemia).
Do not take Norpace if you are already taking other medicines to regulate your heartbeat.

Do not drive or operate machinery as Norpace may cause blurred vision, dizziness and low blood pressure.
Use Norpace with caution if you are elderly (over 65 years of age), have a low body weight, or have kidney or liver problems.

Norpace is used to treat certain irregular heartbeats).
Norpace is in a class of medications called antiarrhythmic drugs.
Norpace works by making your heart more resistant to abnormal activity.

Continuing Education Activity:
Norpace is a chemical used to treat heart rhythm abnormalities that can be life-threatening, such as ventricular tachycardia/fibrillation, or associated with increased morbidity and mortality, such as atrial fibrillation and hypertrophic cardiomyopathy.
This activity reviews several important aspects of this chemical, including indications, mechanism of action, applications, side effects, contraindications, monitoring, and toxicity.
This important knowledge of this chemical can improve interprofessional healthcare team outcomes.

Objectives:
Describe the mechanism of action of Norpace.
Describe possible side effects of Norpace.

Explains the importance of monitoring when using Norpace as an antiarrhythmic chemical.
Outline professional team strategies for improving care coordination and communication when using Norpace to maximize the benefits of this chemical and minimize Norpace side effects.

Indications:
In 1962, new antiarrhythmic drugs were needed apart from quinidine and procainamide, which were the main antiarrhythmic agents available at the time.
Norpace is the selected agent among more than 500 compounds synthesized for the research program of new antiarrhythmic agents.
The chemical structures of Norpace are similar to the synthetic muscarinic antagonist lacquer, which explains Norpace anticholinergic property.

Although Norpace is rarely used for heart rhythm abnormalities due to the availability of newer drugs that provide better efficacy and favorable side-effect profiles, Norpace is still the drug of choice for vagal-mediated atrial fibrillation such as sleep-induced or atrial fibrillation in athlete groups.
The effectiveness of Norpace in these conditions is due to Norpace anticholinergic activity, which abolishes the parasympathetic tone.

Norpace is also a third-line antiarrhythmic agent for a patient with coronary artery disease.
Also, a patient with left ventricular hypertrophy has impaired depolarization, which can induce torsade de pointes.

Therefore, antiarrhythmics that prolong the QT interval are avoided, but if sotalol or amiodarone is unsuccessful or unsuitable, Norpace may be an alternative.
In a patient with atrial fibrillation and hypertrophic obstructive cardiomyopathy (HOCM), Norpace is the agent of choice, other than amiodarone, as Norpace may decrease the left ventricular outflow tract (LVOT) gradient (off-label use).

Data from a multicenter study of the safety and efficacy of Norpace in obstructive cardiomyopathy showed that Norpace significantly reduced the SVOT gradient from 75+/- 33 to 40+/-32 mmHg in 78 patients (66% of study subjects) (P<0.0001). has shown. ) and raises the New York Heart Association functional class (NYHA FC) from 23+/-07 to 17+/-06 (P<0.0001).
When Norpace is used in combination with a non-dihydropyridine calcium channel blocker or beta blocker, they can effectively prevent recurrence of AF in HCOM patients.

Patients with ventricular premature beat (VPB) or premature ventricular complexes (PVC) may have a high symptom burden.
Norpace can be used in patients without structural heart disease, although Norpace efficacy is less than ablation.
In addition, based on a randomized, double-blind, placebo-controlled one-year follow-up study, Norpace (n=44) was effective in maintaining sinus rhythm after electro cardioversion for atrial fibrillation compared to placebo (n=46) and was significantly different (%) at one-month follow-up. 70 vs 39%) and continues after twelve months (54% vs 30%).

Uses of Norpace:
Norpace is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as sustained ventricular tachycardia).
Norpace is used to restore normal heart rhythm and maintain a regular, steady heartbeat.

Norpace is known as an anti-arrhythmic drug.
Norpace works by blocking certain electrical signals in the heart that can cause an irregular heartbeat.
Treating an irregular heartbeat can decrease the risk for blood clots, and this effect can reduce your risk of heart attack or stroke.

Usage of Norpace:
Norpace comes as a capsule and an extended-release (long-acting) capsule to take by mouth.
Norpace capsules may be taken every 6 or 8 hours.

The extended-release capsule is usually taken every 12 hours.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take Norpace exactly as directed.
Do not take more or less of Norpace or take it more often than prescribed by your doctor.

Swallow the extended-release capsules; do not open, crush, or chew them.

Norpace helps control your condition but will not cure it.
Continue to take Norpace even if you feel well.
Do not stop taking Norpace without talking to your doctor.

Mechanism of action of Norpace:
Norpace's Class 1a activity is similar to that of quinidine in that Norpace targets sodium channels to inhibit conduction.
Norpace depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current.

This results in an increased threshold for excitation and a decreased upstroke velocity.
Norpace prolongs the PR interval by lengthening both the QRS and P wave duration.

This effect is particularly well suited in the treatment of ventricular tachycardia as Norpace slows the action potential propagation through the atria to the ventricles.
Norpace does not act as a blocking agent for beta or alpha adrenergic receptors, but does have a significant negative inotropic effect on the ventricular myocardium.
As a result, the use of Norpace may reduce contractile force up to 42% at low doses and up to 100% in higher doses compared to quinidine.

Levites proposed a possible secondary mode of action for Norpace, against reentrant arrhythmias after an ischemic insult.
Norpace decreases the inhomogeneity between infarcted and normal myocardium refractory periods; in addition to lengthening the refractory period.

This decreases the chance of re-entry depolarization, because signals are more likely to encounter tissue in a refractory state which cannot be excited.
This provides a possible treatment for atrial and ventricular fibrillation, as Norpace restores pacemaker control of the tissue to the SA and AV nodes.

Pharmacology and Biochemistry of Norpace:

MeSH Pharmacological Classification:

Anti-Arrhythmia Agents:
Agents used for the treatment or prevention of cardiac arrhythmias.
They may affect the polarization-repolarization phase of the action potential, Norpace excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Obstructive hypertrophic cardiomyopathy:
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease, occurring in 1:500 individuals in the general population.
Norpace is estimated that there are 600,000 individuals in the United States with hypertrophic cardiomyopathy.

The most common variant of HCM presents with left ventricular (LV) intracavitary obstruction due to systolic anterior motion of the mitral valve, and mitral-septal contact, diagnosed readily with echocardiography.
Pharmacologic treatment with negative inotropic drugs is first-line therapy.

Beta-blockers are used first, and while they improve symptoms of shortness of breath, chest pain and exercise intolerance, they do not reduce resting LV intraventricular pressure gradients and often are inadequate to control symptoms.
Many investigators and clinicians believe that Norpace controlled release is the most potent agent available for reducing resting pressure gradients and improving symptoms.

Norpace has been actively used for more than 30 years.
Norpace administration for obstructive HCM has a IB recommendation in the 2020 American Heart Association/American College of Cardiology Foundation guidelines for treatment of obstructive HCM.
A IB treatment recommendation indicates that a treatment is recommended, and may be useful, and beneficial.

Negative inotropes improve LV obstruction by decreasing LV ejection acceleration and hydrodynamic forces on the mitral valve.
Norpace's particular efficacy is due to Norpace potent negative inotropic effects; in head-to-head comparison, Norpace is more effective for gradient reduction than either beta-blocker or verapamil.

Norpace is most often administered with beta-blockade.
When used in patients resistant to beta-blockade, Norpace is effective in 60% of cases, reducing symptoms and gradient to the extent that invasive procedures such as surgical septal myectomy are not required.

Norpace, despite Norpace efficacy, has one main side effect that has limited Norpace use in the US, though Norpace has seen wider application in Canada, UK and Japan.
Vagal blockade predictably causes dry mouth, and in men with prostatism, may cause urinary retention.
Teichman et al. showed that pyridostigmine used in combination with Norpace substantially alleviates vagolytic side effects without compromising antiarrhythmic efficacy.

This combination has also been shown to be effective and safe in obstructive HCM in a large cohort of patients.
Some clinicians prescribe pyridostigmine sustained release (marketed in the US as Mestinon Timespan) to every patient begun on Norpace.
This combination increases acceptance of higher Norpace dosing, important since there is a dose-response correlation in obstructive HCM, higher doses yielding lower gradients.

Another concern about Norpace has been the hypothetical potential for inducing sudden death from Norpace type 1 anti-arrhythmic effects.
However, a multicenter registry and two recent cohort registries have largely reduced this concern, by showing sudden death rates lower than that observed from the disease itself.

These concerns about the drug must be viewed from the clinical perspective that Norpace is generally the last agent that is tried for patients before they are referred for invasive septal reduction with surgical septal myectomy (an open-heart operation) or alcohol septal ablation (a controlled heart attack).
Both of these invasive procedures have risk of morbidity and mortality.

For selected patients, a trial of oral Norpace is a reasonable approach before proceeding to invasive septal reduction.
Patients who respond to Norpace are continued on the drug.

Those who continue to have disabling symptoms or who experience side effects are promptly referred for septal reduction.
Using such a stepped strategy, investigators have reported that survival does not differ from that observed in the age-matched normal United States population.

Extracardiac effects:
Atropine like effects (anticholinergic)
Dry mouth
Constipation
Urinary retention – Norpace should not be given to patients with symptomatic prostatism.
Blurred vision
Glaucoma
Rash
Agranulocytosis

Additionally, Norpace may enhance the hypoglycaemic effect of gliclazide, insulin, and metformin.

Metabolism of Norpace:
Norpace can cause hypoglycemia, perhaps due to increased secretion of insulin, and can also potentiate the effects of conventional hypoglycemic drugs.
This effect may be due to Norpace chief metabolite mono-N dealkylNorpace, since many of the reported cases of hypoglycemia have been in patients with renal impairment, in which the metabolite accumulates.

In six subjects who were being considered for treatment with Norpace, serum glucose concentrations were measured at 13, 15, 17, and 19 hours after supper, with no further food, with and without the added administration of two modified-released tablets of Norpace 150 mg with supper and 12 hours later.
Norpace significantly reduced the serum glucose concentration at all measurement times by an average of 0.54 mmol/l.
The fall in serum glucose concentration was not related to the serum concentration of Norpace or the serum creatinine concentration; Norpace was greater in older patients and in underweight patients.

Hypoglycemia has also been reported in a 70-year-old woman with type 2 diabetes mellitus taking Norpace.

Clinical data of Norpace:
Trade names: Norpace
AHFS/Drugs.com: Monograph
MedlinePlus: a682408
Pregnancy category: AU: B2
Routes ofadministration: Oral, intravenous
ATC code: C01BA03 (WHO)

Legal status:
UK: POM (Prescription only)
US: ℞-only

Pharmacokinetic data of Norpace:
Bioavailability: High
Protein binding: 50% to 65% (concentration-dependent)
Metabolism: Hepatic (CYP3A4-mediated)
Elimination half-life: 6.7 hours (range 4 to 10 hours)
Excretion: Renal (80%)

Identifiers of Norpace:
IUPAC name: (RS)-4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
CAS Number: 3737-09-5
PubChem CID: 3114
IUPHAR/BPS: 7167
DrugBank: DB00280
ChemSpider: 3002
UNII: GFO928U8MQ
KEGG: D00303
ChEBI: CHEBI:4657
ChEMBL: ChEMBL517
CompTox Dashboard (EPA): DTXSID1045536
ECHA InfoCard: 100.021.010

Properties of Norpace:
Formula: C21H29N3O
Molar mass: 339.483 g·mol−1
Melting point: 94.5 to 95 °C (202.1 to 203.0 °F)
SMILES: O=C(N)C(c1ncccc1)(c2ccccc2)CCN(C(C)C)C(C)C
InChI: InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
Key:UVTNFZQICZKOEM-UHFFFAOYSA-N

Molecular Weight: 437.5 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 8
Exact Mass: 437.20795813 g/mol
Monoisotopic Mass: 437.20795813 g/mol
Topological Polar Surface Area: 137Ų
Heavy Atom Count: 30
Complexity: 459
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Names of Norpace:

Regulatory process names:

Disopyramide
Disopyramide

IUPAC names:
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
Disopyramide

Other identifiers:
3737-09-5

Synonyms of Norpace:
Disopyramide PHOSPHATE
22059-60-5
Norpace
Disopyramide PHOSPHATE SALT
Rythmodan
Norpace Cr
SC 7031 phosphate
Dirythmin sa
Diso-duriles
DisopyramidePhosphate
EINECS 244-756-1
SC 7031 (phosphate)
NSC-756744
SC-13957
SC-7031 PHOSPHATE
CHEBI:4658
N6BOM1935W
22059-60-5 (phosphate)
SC 13957
Norpace (TN)
2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate
Disopyramid phosphate
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide;phosphoric acid
alpha-(2-Diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamide phosphate
(+-)-alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1)
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate (1:1)
2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-, phosphate
alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1)
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, (+-)-, phosphate (1:1)
SR-01000003039
Disopyramide (phosphate)
UNII-N6BOM1935W
SCHEMBL41810
MLS000028431
SPECTRUM1500261
C21H29N3O.H3O4P
CHEMBL1201020
HMS501I11
DTXSID30944685
Disopyramide phosphate (JAN/USP)
HMS1920I14
HMS2094K15
HMS2234B16
HMS3259J21
HMS3261C04
HMS3369L05
HMS3652M20
HMS3885J07
Pharmakon1600-01500261
Disopyramide PHOSPHATE [MI]
XAA05960
Disopyramide PHOSPHATE [JAN]
Tox21_500411
CCG-40209
Disopyramide PHOSPHATE [USAN]
HY-12533A
NSC756744
Disopyramide PHOSPHATE [VANDF]
AKOS040744844
Disopyramide PHOSPHATE [MART.]
Disopyramide PHOSPHATE [USP-RS]
Disopyramide PHOSPHATE [WHO-DD]
LP00411
NC00683
NSC 756744
Disopyramide phosphate [USAN:BAN:JAN]
NCGC00093836-01
NCGC00093836-02
NCGC00093836-03
NCGC00093836-04
NCGC00261096-01
SMR000058438
Disopyramide PHOSPHATE [ORANGE BOOK]
LS-130131
Disopyramide PHOSPHATE [EP MONOGRAPH]
Disopyramide phosphate [USAN:USP:BAN:JAN]
EU-0100411
FT-0630479
S4143
SW196836-3
SW196836-4
Disopyramide PHOSPHATE [USP MONOGRAPH]
C07740
D 6035
D00637
SR-01000003039-2
SR-01000003039-6
Q27106430
4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide
(R)-4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide,phosphoric acid
4-DIISOPROPYLAMINO-2-PHENYL-2-(2-PYRIDYL)BUTYRAMIDE PHOSPHATE
Disopyramide phosphate, European Pharmacopoeia (EP) Reference Standard
Disopyramide phosphate, United States Pharmacopeia (USP) Reference Standard
(+/-)-.ALPHA.-(2-(DIISOPROPYLAMINO)ETHYL)-.ALPHA.-PHENYL-2-PYRIDINEACETAMIDE PHOSPHATE (1:1)
2-PYRIDINEACETAMIDE, .ALPHA.-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, (+/-)-, PHOSPHATE (1:1)
223-110-2 [EINECS]
2-pyridineacetamide, a-[2-[bis(1-methylethyl)amino]ethyl]-a-phenyl-
2-Pyridineacetamide, α-(2-(bis(1-methylethyl)amino)ethyl)-α-phenyl-
2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl- [ACD/Index Name]
3737-09-5 [RN]
4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamid [German] [ACD/IUPAC Name]
4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide [ACD/IUPAC Name]
4-(Diisopropylamino)-2-phényl-2-(2-pyridinyl)butanamide [French] [ACD/IUPAC Name]
4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide
4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
4-(dipropan-2-ylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide
a-[2-[Bis(1-methylethyl)amino]ethyl]a-phenyl-2-pyridineacetamide
disopiramida [Spanish] [INN]
Disopyramide [French] [INN]
Disopyramide [BAN] [INN] [JAN] [JP15] [USAN] [Wiki]
Disopyramide, (R)-
Disopyramide, (S)-
disopyramidum [Latin] [INN]
Isorythm
Lispine
MFCD00057366 [MDL number]
Norpace [Trade name]
Rythmodan [Trade name]
α-[2-(DIISOPROPYLAMINO)ETHYL]-α-PHENYL-2-PYRIDINEACETAMIDE
α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide
дизопирамид [Russian] [INN]
ديسوبيراميد [Arabic] [INN]
丙吡胺 [Chinese] [INN]
Disopyramide free base
NORPACE CR
Rythmodan-La
ξ-Disopyramide
[3737-09-5] [RN]
1309283-08-6 [RN]
2-Pyridineacetamide, α-(2-(diisopropylamino)ethyl)-α-phenyl-
2-Pyridineacetamide, α-[2-(diisopropylamino)ethyl]-α-phenyl-
2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-
3737-09-5 (free base)
38236-46-3 [RN]
4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[bis(methylethyl)amino]-2-phenyl-2-(2-pyridyl)butanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanimidic acid
4-[di(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
492056 [Beilstein]
4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide
54687-36-4 [RN]
74464-83-8 [RN]
74464-84-9 [RN]
BS-17145
DB00280
Dicorantil
Disopiramida
Disopiramida [INN-Spanish]
Disopyramide-d5
Disopyramidum
Disopyramidum [INN-Latin]
MFCD00069254 [MDL number]
n-desalkyl Disopyramide
Norpace®
Ritmodan
Rythmodan P [Trade name]
Rythmodan®
Searle 703
α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide
α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide
α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-pyridineacetamide
γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide
γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide
дизопирамид
ديسوبيراميد
丙吡胺
NOVERITE LD920NB POLYMER
Noverite LD920N Polymer is a cost effective, environmentally preferred processing aid for laundry detergent powders and tablets.
Noverite LD920N Polymer is a biodegradable liquid acrylic copolymer designed for reduced energy and water consumption in the manufacture of STPP and zeolite-based laundry detergent powders and tablets.
Noverite LD920N Polymer is a multifunctional, water-soluble modified styrene-maleic copolymer that can be added to liquid or powder detergents.
Noverite LD920N Polymer functions as a polymeric dispersant and anti-redeposition polymer.
Noverite LD920N Polymer enables whiter whites and less dingy laundry by improving secondary cleaning of dirt and soil from fabrics and preventing dirt and soil from redepositing.
Noverite LD920N Polymer is highly efficient, providing benefits without consuming a lot of formulation space.
Noverite LD920N Polymer functions best in anionic and nonionic blended surfactant detergents.

Noverite LD920N Polymer meets the demands for safer ingredients as well as efficient in laundry detergents, and complies with the requirements of the new needs arising from the consumers.
Noverite LD920N Polymer is a unique multifunctional acrylic copolymer designed for laundry detergents, in powder, tablets or liquid, and also for products developed to remove scale from hard water in washing machines.
Noverite LD920N Polymer is presented in liquid form and is biodegradable.
Noverite LD920N Polymer stands out for performing the following functions during the washing processes:

Chelates calcium and magnesium ions
Disperses soiling.
Inhibits growth of carbonate crystals
Modifies the morphology of calcium carbonate crystals
Apart from enhancing the performance of the detergent, Noverite LD920N Polymer can improve the efficiency in manufacturing laundry powdered detergents, which can result in significant reductions in water and energy consumption. This polymer allows to:

Improve plant efficiency by reducing caking
Lower slurry viscosity
Reduce water and energy usage during processing
As with the equivalents for dish washing, the Noverite LD920N Polymer is biodegradable and is included as Safer Choice Ingredient in EPA Safer Choice Program, a program that helps American manufacturers and consumers identify and select products with safer chemical ingredients, without sacrificing quality or performance.

Features and Benefits
Able to maintain cleaning efficacy
Compatibility with a wide range of surfactants for formulation flexibility
Disperses soil
Easy-to-use liquid form
Lowers detergent slurry viscosity
Suitable for post-addition to formulated surfactant detergents
Suitable for use in clear and translucent systems
Novoperm Bordeaux
1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone CAS NO: 2687-94-7
Novoperm Bordeaux HF3R
1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone CAS NO: 2687-94-7
Novoperm Red BLS 02-MX
1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone; cas no: 2687-94-7
Novoperm Red F3RK 70
1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone; cas no: 2687-94-7
Novoperm Red F5RK
Nonylphenol ethoxylated (EO 10); alkyl phenol ethoxylates free; Nonylphenol ethoxylated (EO 30); (EO 40) POE nonyl Phenyl Ether; Ethoxylated nonylphenol; Polyoxyethylene Nonylphenyl Ether; nonylphenyl polyethyleneglycol ether, nonionic; macrogol nonylphenyl ether; Polyethylene Mono(nonylphenyl)ether Glycols; CAS NO:25154-52-3
NOVOPERM YELLOW HR 02
Novoperm Yellow HR 02 NOVOPERM YELLOW HR 02 Novoperm Yellow HR 02 PIGMENT YELLOW 83 Novoperm Yellow HR 02 is a very strong, red shade, transparent diarylide yellow pigment. It exhibits excellent light fastness properties as well as good overall fastness properties. Benefits Excellent fastness properties High tinctorial strength Novoperm Yellow HR 02 Technical Datasheet Diarylide yellow. Is a yellow pigment with particularly high tinctorial strength. It is basically suitable for all paint systems provided the fastness to light and weathering are adequate in individual cases. Has about 15 % higher tinctorial strength compared to Novoperm Yellow HR, is less transparent and is easier to disperse in some paint systems such as air-drying alkyd resin paints as well as in nitrocellulose lacquers. Used in decorative paints. Product Type Color Pigments & Dyes > Organic Pigments Chemical Composition Diarylide yellow CAS Number 5567-15-7 Product identifier Trade name PV Fast Yellow HR 02-BR Material number: 241673 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses of the substance or mixture Industry sector : Industrial Performance Chemicals Paints, lacquers and varnishes industry Polymers industry Printing Inks Industry Type of use : Pigment preparation Novoperm Yellow HR - Pigment Yellow 83 Novoperm Yellow HR is a red shade diarylide yellow pigment with good allround fastness properties NOVOPERM YELLOW HR 02 Novoperm Yellow HR 02 is a very strong, red shade, transparent diarylide yellow pigment. It exhibits excellent light fastness properties as well as good overall fastness properties. Novoperm Yellow HR 02 is Used In Paint and coatings Features of Novoperm Yellow HR 02 Excellent fastness properties High tinctorial strength Typical Properties of Novoperm Yellow HR 02 Color Index of Novoperm Yellow HR 02 P.Y. 83 Density of Novoperm Yellow HR 021.49 Particle Size of Novoperm Yellow HR 02 55 nm
N-OXYDIETHYLENE-2-BENZOTHAIZOLE-SULFENAMIDE
DESCRIPTION:

N-oxydiethylene-2-benzothaizole-sulfenamide is a Standardized Chemical Allergen.
The physiologic effect of N-oxydiethylene-2-benzothaizole-sulfenamide is by means of Increased Histamine Release, and Cell-mediated Immunity.

CAS: 102-77-2
European Community (EC) Number: 203-052-4
IUPAC Name: 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine
Molecular Formula: C11H12N2OS2


SYNONYMS OF N-OXYDIETHYLENE-2-BENZOTHAIZOLE-SULFENAMIDE:
2-(morpholinothio)benzothiazole;n-(oxydiethylene)-benzothiazole-2-sufenamide;n-oxydiethyl-2-benzthiazolsulfenamid;n-oxydiethylene-2-benzothiazole sulfonamide;2-(4-morpholinothio)benzothiazole;2-(4-morpholinothiobenzothiazole;2-(4-morpholinylmercapto)benzothiazole;2-(4-morpholinylsulfanyl)-1,3-benzothiazole;2-(4-morpholinylthio)benzothiazole;2(4-morpholinyl-thio)-benzothiazole;2-(morpholinothio)-benzothiazol;2-(morpholinthio)-benzothiazole;2-benzothiazolesulfenamide, n-morpholinyl-;2-benzothiazolesulfenemorpholide;2-benzothiazolylsufenylmorpholine;2-benzothiazolylsulfenyl morpholine;2-benzothiazolylsulfenylmorpholine;2-benzothiazyl-n-morpholine disulfide;4-(2-benzothiazolylthio)-morpholin;accelerator mf;accelns;amax no 1;benzothiazole, 2-(4-morpholinylthio)-;benzothiazole, 2-(morpholinothio;NOBS;2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole;N-(1,3-benzothiazol-2-ylsulfanyl)morpholin-2-amine;Acelerator NOBS;2-Benzothiazolyl-N-morpholinosulfide;Rubber Accelerator NOBS;Rubber Accelerator MBS;Accelerator NOBS;ACCELERATOR MOR;Accelerator MBS;ACCELERATOR NOBS(MBS,MOR);
MMBT
morpholinyl mercaptobenzothiazole
morpholinylmercaptobenzothiazole
N-oxydiethylene-2-benzothiazole sulfenamide
OBTS
102-77-2
2-(Morpholinothio)benzothiazole
4-(Benzo[d]thiazol-2-ylthio)morpholine
Sulfenamide M
Morpholinylmercaptobenzothiazole
Santocure MOR
Sulfenax MOR
Vulcafor BSM
Vulkacit MOZ
NOBS Special
Usaf cy-7
AMAX
Accel NS
4-(1,3-benzothiazol-2-ylsulfanyl)morpholine
Meramide M
2-(4-Morpholinothio)benzothiazole
Delac MOR
Morpholine, 4-(2-benzothiazolylthio)-
2-(4-Morpholinylthio)benzothiazole
2-(4-Morpholinylmercapto)benzothiazole
N-Oxydiethylene-2-benzothiazylsulfenamide
4-(2-Benzothiazolylthio)morpholine
N-Oxydiethylenebenzothiazole-2-sulfenamide
2-Benzothiazolesulfenemorpholide
N-(Oxydiethylene)benzothiazole-2-sulfenamide
Benzothiazolyl-2-sulfenmorpholide
Benzothiazole, 2-(4-morpholinylthio)-
2-(4-Morpholino)thiobenzothiazole
2-Benzothiazolylsulfenyl morpholine
2-Morpholinothiobenzothiazole
BENZOTHIAZOLE, 2-(MORPHOLINOTHIO)-
2-Benzothiazolyl N-morpholino sulfide
N-(Oxydiethylene)benzothiazylsulfenamide
2-Benzothiazolylsulfenylmorpholine
2-Benzothiazolesulfenamide, N-morpholinyl-
N-Oxydiethylene-2-benzothiazole sulfenamide
N-(Oxodiethylene)-2-benzothiazolesulfenamide
N,N-(Oxydiethylene)-2-benzothiazylsulfenamide
NSC 70078
N,N-(Oxydiethylene)benzothiazole-2-sulfenamide
NSC-70078
VCD7623F3K
(2-Morpholinothio)benzothiazole
DTXSID0021096
Morpholinylmercapto-benzo-thiazole
NSC70078
NCGC00042523-02
NCGC00042523-03
2-(morpholin-4-ylthio)-1,3-benzothiazole
N-(Oxydiethylene)-2-benzothiazolesulfenamide
Vulcafor SSM
2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
N,N-(Oxydiethylene)-2-benzothiazolesulfenamide
Cure-rite OBTS
DTXCID201096
Meramid M
CAS-102-77-2
CCRIS 4911
HSDB 2867
EINECS 203-052-4
BRN 0191684
UNII-VCD7623F3K
AI3-27134
Accelerator NC
2-(Morpholinthio)-benzothiazole
4-(2-Benzothiazolylthio)-morpholine
NOBS
OBTS
2-(4-Morpholino)thiobenzothiazole [HSDB]
EC 203-052-4
NCIOpen2_003384
SCHEMBL79658
4-27-00-01868 (Beilstein Handbook Reference)
MLS000055410
CHEMBL1530581
MHKLKWCYGIBEQF-UHFFFAOYSA-
2-morpholinosulphenyl-benzothiazole
HMS1760H22
HMS2163A20
HMS3323A19
2-(4-morpholinothio)-benzothiazole
4-(2-benzothiazolylthio)-morpholin
Tox21_110976
2-morpholin-4-ylsulfanylbenzothiazole
MFCD00022870
2-Benzothiazolesulfenamide, N-morphol
AKOS001025507
Tox21_110976_1
DB14202
2-(MORPHOLINOTHIO)-BENZOTHIAZOLE
WLN: T56 BN DSJ CS-AT6N DOTJ
BS-42257
N-Oxydiethylene-2-benzothiazolesulfenamide
SMR000066103
2-(4-Morpholinylthio)-1,3-benzothiazole
CS-0201154
FT-0608683
M0532
E78169
2-(4-Morpholinylsulfanyl)-1,3-benzothiazole #
EN300-1726082
A896704
Q-200146
BRD-K97360717-001-07-6
Q27291760
Z56821717
InChI=1/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2

APPLICATIONS OF N-OXYDIETHYLENE-2-BENZOTHAIZOLE-SULFENAMIDE:
N-oxydiethylene-2-benzothiazole sulfonamide acts as an accelerator.
N-oxydiethylene-2-benzothiazole sulfonamide can be used in NR, IR, BR, SBR, NBR and EPDM.

N-oxydiethylene-2-benzothiazole sulfonamide offers excellent mechanical properties to rubbers.
N-oxydiethylene-2-benzothiazole sulfonamide provides extended scorch safety for large size extrusion-, injection & transfer molded products as well as rubber compounds.
The shelf life is 6 months.


This rubber vulcanization accelerator is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles. Is contained in the "mercapto mix".
As a corrosion inhibitor, N-oxydiethylene-2-benzothiazole sulfonamide can be found in cutting fluids or in releasing fluids in the pottery industry.
N-oxydiethylene-2-benzothiazole sulfonamide induces mainly delayed-type hypersensitivity, but a case of immediate-type hypersensitivity was reported in a dental assistant.




CHEMICAL AND PHYSICAL PROPERTIES OF N-OXYDIETHYLENE-2-BENZOTHAIZOLE-SULFENAMIDE
Molecular Weight
252.4 g/mol
XLogP3-AA
2.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Rotatable Bond Count
2
Exact Mass
252.03910536 g/mol
Monoisotopic Mass
252.03910536 g/mol
Topological Polar Surface Area
78.9Ų
Heavy Atom Count
16
Formal Charge
0
Complexity
236
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Name, N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE
Source of Sample, Akron Chemical Company, Akron , Ohio
CAS Registry Number, 102-77-2
Classification, COMPOUNDS CONTAINING SULFUR; UREAS, AMIDES, CYANURATES
Content, Ash Content= 0.15% Moisture Content= 0.50% Nitrogen Content= 10.8-11.2%
Copyright, Copyright © 1980, 1981-2024 John Wiley & Sons, Inc. All Rights Reserved.
Density, (Specific Gravity)= 1.337-1.343
Formula, C11H12N2OS2
InChI, InChI=1S/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2
InChIKey, MHKLKWCYGIBEQF-UHFFFAOYSA-N
Melting Point, 76-88C
Molecular Weight, 252.36
Melting point, 78-80°C
Boiling point, 413.1±55.0 °C(Predicted)
Density, 1.34-1.40
vapor pressure, 0.001Pa at 25℃
refractive index, 1.5650 (estimate)
storage temp., Sealed in dry,2-8°C
solubility, Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly)
form, Solid
pka, 1.05±0.10(Predicted)
color, White to Pale Yellow
Odor, buff to brn. flakes, sweet odor
LogP, 3.4 at 25℃ and pH7
Dissociation constant, -6.82-2.65 at 25℃
CAS DataBase Reference, 102-77-2(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances, N-(OXYDIETHYLENE)BENZOTHIAZOLE-2-SULFENAMIDE
FDA 21 CFR, 177.2600
EWG's Food Scores, 1-2
FDA UNII, VCD7623F3K
NIST Chemistry Reference, Morpholine, 4-(2-benzothiazolylthio)-(102-77-2)
EPA Substance Registry System, Benzothiazole, 2-(4-morpholinylthio)- (102-77-2)



SAFETY INFORMATION ABOUT N-OXYDIETHYLENE-2-BENZOTHAIZOLE-SULFENAMIDE:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product


N-OXYDIETHYLENE-2-BENZOTHAIZOLE-SULFENAMIDE

N-Oxydiethylene-2-benzothiazole-sulfenamide, often abbreviated as OBTS, is a white to light yellow crystalline powder.
N-Oxydiethylene-2-benzothaizole-sulfenamide is primarily used as an accelerator in the vulcanization process of rubber.
N-Oxydiethylene-2-benzothaizole-sulfenamide belongs to the family of benzothiazole sulfenamides, known for their role in enhancing rubber properties.

Chemical Formula: C11H12N2O2S2
Molecular Weight: Approximately 284.35 g/mol
CAS Number: 102-77-2
EC Number: 203-052-4

Synonyms: 2-(Morpholinothio)benzothiazole; 4-(Benzo[d]thiazol-2-ylthio)morpholine; Sulfenamide M; Morpholinylmercaptobenzothiazole; Santocure MOR; Sulfenax MOR; Vulcafor BSM; Vulkacit MOZ; NOBS Special; Usaf cy-7; AMAX; Accel NS; 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine; Meramide M; 2-(4-Morpholinothio)benzothiazole; Delac MOR; Morpholine, 4-(2-benzothiazolylthio)-; 2-(4-Morpholinylthio)benzothiazole; N-Oxydiethylenebenzothiazole-2-sulfenamide; 2-(4-Morpholinylmercapto)benzothiazole; N-Oxydiethylene-2-benzothiazylsulfenamide; 4-(2-Benzothiazolylthio)morpholine; 2-Benzothiazolesulfenemorpholide; N-(Oxydiethylene)benzothiazole-2-sulfenamide; Benzothiazolyl-2-sulfenmorpholide; Benzothiazole, 2-(4-morpholinylthio)-; 2-(4-Morpholino)thiobenzothiazole; 2-Benzothiazolylsulfenyl morpholine; 2-Morpholinothiobenzothiazole; BENZOTHIAZOLE, 2-(MORPHOLINOTHIO)-; 2-Benzothiazolyl N-morpholino sulfide; N-(Oxydiethylene)benzothiazylsulfenamide; 2-Benzothiazolylsulfenylmorpholine; 2-Benzothiazolesulfenamide, N-morpholinyl-; N-Oxydiethylene-2-benzothiazole sulfenamide; N-(Oxodiethylene)-2-benzothiazolesulfenamide; N,N-(Oxydiethylene)-2-benzothiazylsulfenamide; NSC 70078; N,N-(Oxydiethylene)benzothiazole-2-sulfenamide; 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole; NSC-70078; VCD7623F3K; (2-Morpholinothio)benzothiazole; DTXSID0021096; Morpholinylmercapto-benzo-thiazole; NSC70078; NCGC00042523-02; NCGC00042523-03; 2-(morpholin-4-ylthio)-1,3-benzothiazole; N-(Oxydiethylene)-2-benzothiazolesulfenamide; Vulcafor SSM; N,N-(Oxydiethylene)-2-benzothiazolesulfenamide; Cure-rite OBTS; DTXCID201096; Meramid M; CAS-102-77-2; CCRIS 4911; HSDB 2867; EINECS 203-052-4; BRN 0191684; UNII-VCD7623F3K; AI3-27134; Accelerator NC; 2-(Morpholinthio)-benzothiazole; 4-(2-Benzothiazolylthio)-morpholine; NOBS; OBTS; 2-(4-Morpholino)thiobenzothiazole [HSDB]; EC 203-052-4; NCIOpen2_003384; SCHEMBL79658; 4-27-00-01868 (Beilstein Handbook Reference); MLS000055410; CHEMBL1530581; MHKLKWCYGIBEQF-UHFFFAOYSA-; 2-morpholinosulphenyl-benzothiazole; HMS1760H22; HMS2163A20; HMS3323A19; 2-(4-morpholinothio)-benzothiazole; 4-(2-benzothiazolylthio)-morpholin; Tox21_110976; 2-morpholin-4-ylsulfanylbenzothiazole; MFCD00022870; 2-Benzothiazolesulfenamide, N-morphol; AKOS001025507; Tox21_110976_1; DB14202; 2-(MORPHOLINOTHIO)-BENZOTHIAZOLE; WLN: T56 BN DSJ CS-AT6N DOTJ; BS-42257; N-Oxydiethylene-2-benzothiazolesulfenamide; SMR000066103; 2-(4-Morpholinylthio)-1,3-benzothiazole; CS-0201154; FT-0608683; M0532; NS00004147; E78169; 2-(4-Morpholinylsulfanyl)-1,3-benzothiazole #; EN300-1726082; A896704; Q-200146; BRD-K97360717-001-07-6; Q27291760; Z56821717



APPLICATIONS


N-Oxydiethylene-2-benzothaizole-sulfenamide is extensively used as an accelerator in the vulcanization of natural rubber.
N-Oxydiethylene-2-benzothaizole-sulfenamide plays a crucial role in the production of tires, enhancing their strength and durability.

N-Oxydiethylene-2-benzothaizole-sulfenamide accelerates the curing process of rubber, optimizing production efficiency in tire manufacturing.
N-Oxydiethylene-2-benzothaizole-sulfenamide is essential in the formulation of rubber conveyor belts, ensuring robustness and wear resistance.

N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the manufacturing of industrial hoses, providing flexibility and chemical resistance.
N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the production of automotive parts such as seals and gaskets, ensuring reliable performance under varying conditions.
N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the formulation of rubber footwear, enhancing grip and durability in shoe soles.

N-Oxydiethylene-2-benzothaizole-sulfenamide is utilized in the production of rubberized fabrics used in protective clothing and industrial applications.
N-Oxydiethylene-2-benzothaizole-sulfenamide enhances the aging resistance of rubber products, extending their lifespan in various applications.

N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the production of rubber diaphragms and membranes used in pumps and fluid handling systems.
N-Oxydiethylene-2-benzothaizole-sulfenamide is crucial in the manufacturing of rubber components for electrical insulation and cable sheathing.

N-Oxydiethylene-2-benzothaizole-sulfenamide improves the weather resistance of rubber roofing materials and waterproof membranes.
N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the formulation of vibration-damping rubber mounts and bushings for automotive and machinery applications.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the production of rubber seals and gaskets for aerospace applications, ensuring reliability under extreme conditions.

N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the formulation of rubber compounds for marine applications, providing resistance to saltwater and environmental exposure.
N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the construction industry for rubberized components in building materials and infrastructure.

N-Oxydiethylene-2-benzothaizole-sulfenamide plays a role in the formulation of specialty rubber compounds for sporting goods, including balls and athletic equipment.
N-Oxydiethylene-2-benzothaizole-sulfenamide is utilized in the production of rubber rollers used in printing and manufacturing processes.

N-Oxydiethylene-2-benzothaizole-sulfenamide enhances the performance of rubberized coatings and linings for tanks, pipes, and industrial equipment.
N-Oxydiethylene-2-benzothaizole-sulfenamide is essential in the production of rubber components for agricultural machinery, ensuring resilience and durability.

N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the formulation of rubber parts for medical devices and equipment, meeting stringent safety and performance standards.
N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the production of rubberized components for renewable energy applications, including solar panel mounts and wind turbine components.
N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the formulation of rubber compounds for mining equipment, providing resistance to abrasive materials.

N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the production of specialty rubber products for aerospace seals, O-rings, and critical components.
In summary, N-Oxydiethylene-2-benzothiazole-sulfenamide (OBTS) is widely applied in various industries for enhancing the performance, durability, and reliability of rubber products in diverse applications ranging from automotive and construction to aerospace and renewable energy sectors.

N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the formulation of rubber seals and gaskets for HVAC (Heating, Ventilation, and Air Conditioning) systems, ensuring efficient performance and sealing properties.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the production of rubber components for marine vessels, including fenders and docking equipment, providing durability and resilience in maritime environments.

N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the formulation of rubber flooring materials used in commercial and industrial settings, offering slip resistance and durability.
N-Oxydiethylene-2-benzothaizole-sulfenamide is utilized in the production of automotive rubber belts and hoses, ensuring reliability and longevity in engine components.
N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the formulation of rubberized components for railway infrastructure, including track pads and vibration dampers, enhancing safety and operational efficiency.

N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the production of rubberized gloves and protective gear for industrial workers, providing chemical resistance and comfort.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the formulation of rubber seals and components for hydraulic systems, ensuring leak-free performance and durability.

N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the production of rubberized components for household appliances, offering noise reduction and vibration isolation.
N-Oxydiethylene-2-benzothaizole-sulfenamide is utilized in the formulation of rubber profiles and seals for windows and doors, enhancing insulation and weatherproofing properties.

N-Oxydiethylene-2-benzothaizole-sulfenamide plays a role in the production of rubberized components for recreational vehicles (RVs) and trailers, providing durability and reliability on the road.
N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the formulation of rubber parts for bicycles and motorcycles, including tires and inner tubes, ensuring performance and safety.

N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the production of rubberized conveyor belts for industrial and mining applications, providing strength and reliability in material handling.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the formulation of rubberized components for water treatment systems, offering resistance to chemicals and environmental conditions.

N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the production of rubberized components for food processing equipment, ensuring compliance with hygiene and safety standards.
N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the formulation of rubber seals and components for aerospace applications, including aircraft seals and gaskets, ensuring reliability in extreme conditions.
N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the production of rubberized components for medical devices and healthcare equipment, meeting stringent regulatory requirements.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the formulation of rubberized components for construction vehicles and heavy machinery, providing durability and performance in construction sites.

N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the production of rubberized components for power transmission systems, including belts and pulleys, ensuring efficient operation.
N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the formulation of rubberized components for sporting equipment, such as balls, padding, and protective gear, enhancing performance and safety.

N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the production of rubberized components for leisure and recreational equipment, including playground surfaces and athletic tracks.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the formulation of rubberized components for military applications, including vehicle seals and protective gear, ensuring durability and reliability in harsh environments.
N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the production of rubberized components for aerospace fuel systems, providing resistance to fuels and lubricants.

N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the formulation of rubberized components for consumer electronics, offering shock absorption and protection in electronic devices.
N-Oxydiethylene-2-benzothaizole-sulfenamide is used in the production of rubberized components for renewable energy applications, including solar panel mounts and wind turbine blades, providing durability and weather resistance.

N-Oxydiethylene-2-benzothaizole-sulfenamide's chemical structure includes a benzothiazole ring and a sulfenamide functional group.
N-Oxydiethylene-2-benzothaizole-sulfenamide aids in the production of vibration-damping rubber mounts and bushings in automotive and machinery applications.
N-Oxydiethylene-2-benzothaizole-sulfenamide is employed in the formulation of rubber components for electrical insulation and cable sheathing.

N-Oxydiethylene-2-benzothaizole-sulfenamide is recognized for its role in improving the weather resistance of rubber roofing materials and waterproof membranes.
N-Oxydiethylene-2-benzothaizole-sulfenamide is subject to regulatory guidelines regarding its manufacture, handling, and disposal.

N-Oxydiethylene-2-benzothaizole-sulfenamide is used in specialized rubber compounds for aerospace applications, including seals and gaskets.
In summary, N-Oxydiethylene-2-benzothiazole-sulfenamide (OBTS) is a versatile accelerator that enhances the performance, durability, and reliability of rubber products across various industries.



DESCRIPTION


N-Oxydiethylene-2-benzothiazole-sulfenamide, often abbreviated as OBTS, is a white to light yellow crystalline powder.
N-Oxydiethylene-2-benzothaizole-sulfenamide is primarily used as an accelerator in the vulcanization process of rubber.

N-Oxydiethylene-2-benzothaizole-sulfenamide belongs to the family of benzothiazole sulfenamides, known for their role in enhancing rubber properties.
N-Oxydiethylene-2-benzothaizole-sulfenamide facilitates the cross-linking of rubber molecules during vulcanization, improving elasticity and strength.

N-Oxydiethylene-2-benzothaizole-sulfenamide accelerates the curing time of rubber, optimizing production efficiency in various industries.
N-Oxydiethylene-2-benzothaizole-sulfenamide is insoluble in water but soluble in organic solvents such as acetone and ethanol.

The melting point of OBTS ranges from approximately 84 to 87°C.
N-Oxydiethylene-2-benzothaizole-sulfenamide is compatible with a wide range of rubber polymers, including natural rubber and various synthetic rubbers.
N-Oxydiethylene-2-benzothaizole-sulfenamide is known for its effectiveness in enhancing the aging resistance and durability of rubber products.

In industrial applications, OBTS is crucial in the production of tires, conveyor belts, and automotive components.
N-Oxydiethylene-2-benzothaizole-sulfenamide acts as a processing aid, improving the dispersion of fillers and other additives in rubber compounds.
N-Oxydiethylene-2-benzothaizole-sulfenamide is handled with care due to its potential for skin irritation and sensitization upon prolonged contact.

Safety precautions, including the use of gloves and goggles, are recommended during handling.
N-Oxydiethylene-2-benzothaizole-sulfenamide is important to follow proper storage conditions to maintain its stability and effectiveness.
N-Oxydiethylene-2-benzothaizole-sulfenamide plays a role in the production of rubber seals, gaskets, and industrial hoses, ensuring resilience and longevity.

N-Oxydiethylene-2-benzothaizole-sulfenamide is essential in achieving the desired properties of rubber footwear, including flexibility and grip.
N-Oxydiethylene-2-benzothaizole-sulfenamide contributes to the development of rubberized fabrics used in protective clothing and industrial applications.
N-Oxydiethylene-2-benzothaizole-sulfenamide enhances the performance of rubber diaphragms and membranes used in pumps and fluid handling systems.



PROPERTIES


Physical Properties:

Appearance: White to light yellow crystalline powder
Odor: Odorless
Melting Point: Approximately 84-87°C
Boiling Point: Decomposes before boiling
Density: ~1.27 g/cm³
Solubility in Water: Insoluble
Solubility in Other Solvents: Soluble in organic solvents such as acetone, ethanol, and benzene
Partition Coefficient (Log P): Not applicable (insoluble in water)
Vapor Pressure: Negligible at ambient temperatures


Chemical Properties:

Chemical Formula: C11H12N2O2S2
Molecular Weight: Approximately 284.35 g/mol
CAS Number: 102-77-2
EC Number: 203-052-4 (not officially assigned, but sometimes referenced in regulatory contexts)
Structure: Contains a benzothiazole ring with an attached sulfenamide functional group and an oxydiethylene linkage
Acidity/Basicity: Neutral pH in aqueous solutions
Stability: Stable under normal storage conditions; may decompose at high temperatures or in the presence of strong acids or bases
Flammability: Non-flammable
Reactivity: Reacts with strong oxidizing agents
Hazardous Polymerization: Will not occur



FIRST AID


Inhalation:

Move the affected person to fresh air immediately.
If breathing is difficult, provide oxygen if trained to do so.
Seek medical attention promptly.


Skin Contact:

Remove contaminated clothing and shoes immediately.
Wash the affected skin thoroughly with soap and water for at least 15 minutes.
Use a mild soap and lukewarm water to avoid further irritation.
If irritation persists or develops, seek medical advice.
Wash contaminated clothing before reuse.


Eye Contact:

Rinse eyes gently with water for at least 15 minutes, holding eyelids open to ensure thorough flushing.
Remove contact lenses if present and easily removable.
Seek immediate medical attention if irritation or redness persists.


Ingestion:

Do not induce vomiting unless directed by medical personnel.
Rinse mouth with water if the person is conscious and able to swallow.
Seek immediate medical attention.
Provide medical personnel with information about the chemical ingested.


General First Aid:

Personal Protection:
Wear appropriate personal protective equipment (PPE) during first aid response (gloves, safety goggles).

Medical Attention:
Always seek medical attention after any exposure, even if symptoms are not immediately apparent.

Symptom Management:
Treat symptoms based on the individual's condition and observed symptoms.

Emergency Contact: Have the product container or Safety Data Sheet (SDS) available for medical personnel, providing necessary information about the chemical and its potential health effects.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear suitable protective gloves, safety goggles, and clothing to prevent skin contact and eye exposure.
Use respiratory protection (e.g., NIOSH-approved respirator) if handling in an area with inadequate ventilation or potential for airborne exposure.

Handling Precautions:
Handle OBTS in a well-ventilated area or under local exhaust ventilation to minimize inhalation exposure.
Avoid contact with eyes, skin, and clothing.
In case of contact, follow first aid measures immediately (see previous response).
Prevent the formation of dust. Use appropriate containment measures (e.g., dust extraction, vacuum cleaning) if handling as a powder or granular form.

Avoidance of Incompatible Materials:
Keep OBTS away from strong oxidizing agents, acids, and bases, which may react with the compound and cause hazardous conditions.
Store OBTS separately from food and feedstuffs to prevent contamination.

Handling Procedures:
Use tools and equipment that are grounded to prevent static electricity buildup.
Minimize spills and leaks. In case of spillage, clean up immediately using suitable absorbent materials. Dispose of according to local regulations.


Storage:

Storage Conditions:
Store OBTS in a cool, dry, well-ventilated area away from direct sunlight and heat sources.
Maintain temperature control within recommended limits (typically room temperature).
Store in tightly closed containers to prevent contamination and moisture absorption.

Compatibility:
Store OBTS away from incompatible materials as mentioned earlier.
Ensure containers are labeled clearly with the product name, hazard symbols, and safety precautions.

Specific Storage Requirements:
Follow manufacturer's recommendations and guidelines specified in the Safety Data Sheet (SDS) for storage duration and conditions.
Periodically inspect containers for signs of damage or deterioration.
Replace damaged containers promptly.

Fire and Explosion Hazards:
OBTS is non-flammable and does not pose a fire hazard under normal storage conditions.
However, avoid exposure to open flames and high temperatures.

Emergency Planning:
Have appropriate spill control measures, personal protective equipment, and emergency response procedures in place.
Train personnel on safe handling practices, emergency procedures, and the use of PPE.

N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS)

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a high-performance rubber accelerator commonly used in the vulcanization process of rubber products.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is known for its ability to improve the physical properties of rubber, such as elasticity, tensile strength, and resistance to heat.
The chemical formula for N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is C11H14N2O2S2, and it is widely used in various industrial applications due to its effective properties.

CAS Number: 52343-17-2
EC Number: 257-477-7

Synonyms: OBTS, N-(2-(2-Hydroxyethoxy)ethyl)-2-benzothiazolesulfenamide, Oxydiethylene Benzothiazolesulfenamide, OBTS Accelerator, Vulcanization Accelerator OBTS, 2-Benzothiazolesulfenamide, Accelerator OBTS



APPLICATIONS


N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is extensively used as a primary accelerator in the vulcanization of natural and synthetic rubbers.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is particularly favored in the production of tires, offering excellent scorch safety and improved curing efficiency.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the manufacturing of industrial rubber products such as hoses, belts, and seals, enhancing their durability and flexibility.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is widely used in the production of automotive rubber components, including gaskets, weatherstrips, and vibration dampening products, ensuring optimal performance.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the formulation of rubber compounds for footwear, providing superior flexibility, wear resistance, and comfort.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is essential in the rubber industry for the production of conveyor belts, improving their tensile strength and longevity.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the creation of rubberized fabrics, offering improved elasticity and durability for industrial and consumer applications.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a key component in the manufacture of rubber-based adhesives and sealants, contributing to their strong bonding capabilities and long-term performance.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the formulation of specialty rubber compounds used in high-performance applications, ensuring consistent quality and durability.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is applied in the production of rubber products for the construction industry, such as rubber mats and protective coatings, enhancing their resistance to environmental factors.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the production of rubber sheets and films, improving their flexibility, tear resistance, and tensile strength.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the manufacturing of rubber insulation materials, providing enhanced thermal stability and resistance to aging.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is found in the production of rubber seals and O-rings, ensuring their durability and resistance to harsh environmental conditions.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the automotive industry for the production of high-performance rubber hoses, contributing to their heat resistance and long service life.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the formulation of rubber compounds for anti-vibration products, offering excellent shock absorption and resilience.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the production of specialty rubber compounds for the aerospace industry, ensuring high performance under extreme conditions.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the manufacturing of rubber components for marine applications, providing resistance to saltwater corrosion and UV exposure.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is found in the production of rubber grommets and bushings, enhancing their flexibility, wear resistance, and long-term performance.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the creation of rubber linings for industrial equipment, offering enhanced resistance to abrasion and chemical exposure.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the production of rubber components for mining applications, providing superior durability, impact resistance, and longevity.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the formulation of rubber compounds for high-pressure hydraulic seals, ensuring their long-term stability and performance under demanding conditions.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the production of rubber profiles for construction joints, providing enhanced sealing properties and durability.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the manufacturing of rubber components for railway applications, contributing to their wear resistance and durability under heavy loads.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the production of rubber components for oil and gas exploration, ensuring their performance and resistance to high-pressure environments.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is found in the formulation of rubber compounds for industrial rollers, offering improved wear resistance, load-bearing capacity, and longevity.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the creation of specialty rubber compounds for high-temperature applications, ensuring their stability and performance in extreme conditions.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a key component in the production of rubber components for heavy machinery, enhancing their durability and resistance to harsh environments.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the production of rubber components for industrial valves, offering improved sealing properties, chemical resistance, and long-term reliability.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the formulation of rubber compounds for electrical insulation, ensuring their stability, safety, and long-term performance.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the production of rubber belts and drive systems, enhancing their flexibility, load-bearing capacity, and service life.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is found in the manufacturing of rubber components for the food and beverage industry, ensuring compliance with safety standards and long-term durability.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the formulation of rubber compounds for medical applications, offering biocompatibility, sterilizability, and performance under stringent conditions.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is employed in the creation of rubber linings for storage tanks, providing resistance to chemical corrosion and long-term durability.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is utilized in the production of rubber components for agricultural machinery, offering durability, resistance to wear, and performance in demanding conditions.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is used in the formulation of rubber compounds for high-performance automotive parts, providing enhanced heat resistance, wear resistance, and overall performance.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a key ingredient in the production of rubber components for the electronics industry, ensuring their stability, durability, and long-term performance.



DESCRIPTION


N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a high-performance rubber accelerator commonly used in the vulcanization process of rubber products.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is known for its ability to improve the physical properties of rubber, such as elasticity, tensile strength, and resistance to heat.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a versatile chemical compound used in various rubber applications.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) provides excellent scorch safety, allowing for extended processing times without compromising the quality of the final product.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is essential in the production of high-performance rubber products, contributing to their strength, resilience, and resistance to wear.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is widely used in the automotive industry, where it enhances the performance and durability of rubber components.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is also employed in the manufacturing of industrial rubber products, including hoses, seals, and gaskets, ensuring their long-term reliability and performance.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a critical accelerator in the vulcanization process, providing optimal curing and improving the overall quality of rubber compounds.

N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is recognized for its stability, effectiveness, and versatility in a wide range of rubber applications, from automotive components to industrial products.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is essential in the formulation of specialty rubber compounds, providing consistent performance and long-term reliability.
N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is a key ingredient in the production of rubber materials used in demanding environments, ensuring their resistance to extreme conditions and prolonged use.



PROPERTIES


Chemical Formula: C11H14N2O2S2
Common Name: N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS)
Molecular Structure:
Appearance: Light yellow powder
Density: 1.32 g/cm³
Melting Point: 130-135°C
Solubility: Insoluble in water; soluble in benzene, acetone, and chloroform
Flash Point: 225°C
Reactivity: Stable under normal conditions; decomposes at high temperatures
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store below 25°C in a dry, well-ventilated area
Vapor Pressure: Negligible at room temperature



FIRST AID


Inhalation:
If N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust or vapors.
Do not eat, drink, or smoke while handling N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS).
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Avoid generating dust. Sweep up and collect the material for disposal in a sealed container.

Storage:
Store N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) in a cool, dry, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust or aerosols.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust or vapors may be present.


Storage:

Temperature:
Store N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) away from incompatible materials, including strong acids, bases, and oxidizing agents.

Handling Equipment:
Use dedicated equipment for handling N-Oxydiethylene-2-Benzothiazole Sulfenamide (OBTS) to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS)
DESCRIPTION:


Accelerator N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is recommended as a primary accelerator for natural and synthetic rubbers.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) offers more processing safety than MBT, MBTS, BBTS, or CBTS. OBTS (sometimes referred to as MBS) can be compounded alone or in conjunction with many secondary accelerators

CAS Registry Number 102-77-2
Mol Weight 252.35 g/mol
Molecular Formula C11H12N2OS2
Exact Mass 252.039105 g/mol


SYNONYMS OF N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS):
OBTS,4-(2-BENZOTHIAZOLYLTHIO)MORPHOLINE,AKROCHEM OBTS,ACCELERATOR,MORPHOLINYLMERCAPTOBENZOTHIAZOLE,2-BENZOTHIAZOLYL N-MORPHOLINOSULFIDE,2-(MORPHOLINOTHIO)BENZOTHIAZOLE,2-(morpholinothio)benzothiazole;n-(oxydiethylene)-benzothiazole-2-sufenamide;n-oxydiethyl-2-benzthiazolsulfenamid;n-oxydiethylene-2-benzothiazole sulfonamide;2-(4-morpholinothio)benzothiazole;2-(4-morpholinothiobenzothiazole;2-(4-morpholinylmercapto)benzothiazole;2-(4-morpholinylsulfanyl)-1,3-benzothiazole;2-(4-morpholinylthio)benzothiazole;2(4-morpholinyl-thio)-benzothiazole;2-(morpholinothio)-benzothiazol;2-(morpholinthio)-benzothiazole;2-benzothiazolesulfenamide, n-morpholinyl-;2-benzothiazolesulfenemorpholide;2-benzothiazolylsufenylmorpholine;2-benzothiazolylsulfenyl morpholine;2-benzothiazolylsulfenylmorpholine;2-benzothiazyl-n-morpholine disulfide;4-(2-benzothiazolylthio)-morpholin;accelerator mf;accelns;amax no 1;benzothiazole, 2-(4-morpholinylthio)-;benzothiazole, 2-(morpholinothio;NOBS;2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole;N-(1,3-benzothiazol-2-ylsulfanyl)morpholin-2-amine;Acelerator NOBS;2-Benzothiazolyl-N-morpholinosulfide;Rubber Accelerator NOBS;Rubber Accelerator MBS;Accelerator NOBS;ACCELERATOR MOR;Accelerator MBS;ACCELERATOR NOBS(MBS,MOR);



N-Oxydiethylenebenzothiazole-2-sulfenamide is a sealant that has been shown to be effective in vitro against malignant cells.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) reacts with the cell nuclei and prevents the production of DNA by interfering with the formation of disulfide bonds.

In vivo studies have shown that N-oxydiethylenebenzothiazole-2-sulfenamide is not absorbed into the bloodstream and can be used as an agent for sealing brain lesions.
This drug has also been shown to inhibit epidermal growth factor (EGF) and reduce glioma growth in animal models.
N-Oxydiethylenebenzothiazole-2-sulfenamide may also have antiangiogenic effects, which may account for its inhibition of EGF.



Accelerator N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is a primary accelerator for natural- and synthetic rubber.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) offers more processing safety than MBT, MBTS, BBTS or CBTS.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is a masterbatch and can be used in combination with a secondary accelerator.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is designed for thick cross-section articles where delayed scorch and rapid cure is required.
Accelerator N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is suitable for injection molding.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is easy to handle polymer-bound dispersion providing better uniformity of mix at low temperature, upgrade plant safety and quality.
The recommended dosage is 0.5-3.5 phr depending on the length of time needed to prevent on-set of cures.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Light yellow prill with little odor of ammonia, no poison.
The density is 1.31-1.34.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Soluble in Chloroform, Benzene, Acetone.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Insoluble in water, gasoline, acid/alkali with lower concentration.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) will decompose step by step with temperature over 60’C



APPLICATIONS OF N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS):
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is recommended for applications where extended processing safety is required.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is particularly useful for thick cross section articles where delayed scorch and rapid cure completion are a must.
Typical dosages range from 0.5 to 3.5 PHR depending on the length of timed needed to prevent on-set of cure.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) provides an effective compounding tool to improve bin stability.
Its long scorch delay is also advantageous in injection molding allowing the safe use of high injection temperatures.


N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is a vulcanizing accelerator with delayed reaction and short cure time.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Widely used in NR, IR, SBR, NBR and EPDM.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) Can be used alone or with other vulcanization accelerators such as thiurams, guanidines and dithiocarbamates to improve activity.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) has high anti-scorching qualities and a processing safety.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is used in the manufacture of tires, rubber tubes, rubber footwear and hoses.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Especially suitable for synthetic rubber mixed with fine furnace carbon black.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Soluble in acetone organic liquids, including fats and oils of ether.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Insoluble in water.

N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is An excellent delayed accelerator.
The performance is similar to CBS with better scorch safety.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is recommended for applications where extended scorch safety such as thick extrusions, stocks with high loading of furnace blacks such as ISAF&SAF.


N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) Can be used alone or with other vulcanization accelerator such as thiurams, guanidiness and dithocarbamates to improve be activity.
N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is Mainly used in Manufacture of tires, tubes, foot wear, rubber belt and hose etc.




CHEMICAL DISPERSIONS:
Accelerator N-oxydiethylene-2-benzothiazole Sulfenamide (OBTS) is also available as a polymeric masterbatch.
Polymer bound or encapsulated dispersions are a proven means of upgrading plant safety, efficiency, quality & raw material control.



CHEMICAL AND PHYSICAL PROPERTIES OF N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS):

Density (Specific Gravity)= 1.337-1.343
Formula C11H12N2OS2
InChI InChI=1S/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2
InChIKey MHKLKWCYGIBEQF-UHFFFAOYSA-N
Melting Point 76-88C
Molecular Weight 252.36
Appearance. .. . buff pellet
Melting Point. . . 82°C min.
Ash. . . 0.30% max
Moisture. . .. 0.30% max
Specific Gravity. . . 1.36
Packaging. . . 55.1 pound bags
Density 1.34 - 1.40 g/cm3
Bulk Density 1360 kg/m3
Solubility in water INSOLUBLE
Other Solubility Soluble in acetone organic liquids, including fats and oils of ether
Melting Point 80°C
Molecular Weight 253.35
Molecular Formula C11H12N2S2O
Appearance Light yellow granules or crystals
Odour Mild Amine
Specific Gravity 1.40 @ 25°C



SAFETY INFORMATION ABOUT N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS)
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.



N-OXYDIETHYLENE-2-BENZOTHIAZOLE SULFENAMIDE (OBTS)
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is contained in the "mercapto mix".
As a corrosion inhibitor, N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) can be found in cutting fluids or in releasing fluids in the pottery industry.

CAS: 102-77-2
MF: C11H12N2OS2
MW: 252.36
EINECS: 203-052-4

N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) induces mainly delayed-type hypersensitivity, but a case of immediate-type hypersensitivity was reported in a dental assistant.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is a primary accelerator for natural- and synthetic rubber.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) offers more processing safety than MBT, MBTS, BBTS or CBTS.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is a masterbatch and can be used in combination with a secondary accelerator.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is designed for thick cross-section articles where delayed scorch and rapid cure is required.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is suitable for injection molding.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is easy to handle polymer-bound dispersion providing better uniformity of mix at low temperature, upgrade plant safety and quality.
The recommended dosage of N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is 0.5-3.5 phr depending on the length of time needed to prevent on-set of cures.

N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) Chemical Properties
Melting point: 78-80°C
Boiling point: 413.1±55.0 °C(Predicted)
Density: 1.34-1.40
Vapor pressure: 0.001Pa at 25℃
Refractive index: 1.5650 (estimate)
Storage temp.: Sealed in dry,2-8°C
Solubility: Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly)
Form: Solid
pka: 1.05±0.10(Predicted)
Color: White to Pale Yellow
Odor: buff to brn. flakes, sweet odor
LogP: 3.4 at 25℃ and pH7
Dissociation constant: -6.82-2.65 at 25℃
CAS DataBase Reference: 102-77-2(CAS DataBase Reference)
NIST Chemistry Reference: N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) (102-77-2)
EPA Substance Registry System: N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) (102-77-2)

Uses
Delayed-action vulcanization accelerator.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is recommended for applications where extended processing safety is required.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is particularlyuseful for thick cross section articles where delayed scorch and rapid cure completion are a must.
Typical dosages range from 0.5 to 3.5 PHR depending on the length of timed needed to prevent on-setof cure.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) provides an effective compounding tool to improve bin stability.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS)'s long scorch delay is also advantageous in injection molding allowing the safe use of high injection temperatures.

Contact allergens
This rubber vulcanization accelerator belongs to the mercaptobenzothiazole-sulfenamide group.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) is contained in “mercapto mix.”
As a corrosion inhibitor, N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) can be found in cutting fluids or in releasing fluids in the pottery industry.
N-oxydiethylene-2-benzothiazole sulfenamide ( OBTS) induces mainly delayed-type hypersensitivity, but a case of immediate-type hypersensitivity was reported in a dental assistant.

Synonyms
102-77-2
2-(Morpholinothio)benzothiazole
4-(Benzo[d]thiazol-2-ylthio)morpholine
Sulfenamide M
Morpholinylmercaptobenzothiazole
Santocure MOR
Sulfenax MOR
Vulcafor BSM
Vulkacit MOZ
NOBS Special
Usaf cy-7
AMAX
Accel NS
4-(1,3-benzothiazol-2-ylsulfanyl)morpholine
Meramide M
2-(4-Morpholinothio)benzothiazole
Delac MOR
Morpholine, 4-(2-benzothiazolylthio)-
2-(4-Morpholinylthio)benzothiazole
2-(4-Morpholinylmercapto)benzothiazole
N-Oxydiethylene-2-benzothiazylsulfenamide
4-(2-Benzothiazolylthio)morpholine
N-Oxydiethylenebenzothiazole-2-sulfenamide
2-Benzothiazolesulfenemorpholide
N-(Oxydiethylene)benzothiazole-2-sulfenamide
Benzothiazolyl-2-sulfenmorpholide
Benzothiazole, 2-(4-morpholinylthio)-
2-(4-Morpholino)thiobenzothiazole
2-Benzothiazolylsulfenyl morpholine
2-Morpholinothiobenzothiazole
BENZOTHIAZOLE, 2-(MORPHOLINOTHIO)-
2-Benzothiazolyl N-morpholino sulfide
N-(Oxydiethylene)benzothiazylsulfenamide
2-Benzothiazolylsulfenylmorpholine
2-Benzothiazolesulfenamide, N-morpholinyl-
N-Oxydiethylene-2-benzothiazole sulfenamide
N-(Oxodiethylene)-2-benzothiazolesulfenamide
N,N-(Oxydiethylene)-2-benzothiazylsulfenamide
NSC 70078
N,N-(Oxydiethylene)benzothiazole-2-sulfenamide
NSC-70078
VCD7623F3K
(2-Morpholinothio)benzothiazole
DTXSID0021096
Morpholinylmercapto-benzo-thiazole
NSC70078
NCGC00042523-02
NCGC00042523-03
2-(morpholin-4-ylthio)-1,3-benzothiazole
N-(Oxydiethylene)-2-benzothiazolesulfenamide
Vulcafor SSM
2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
N,N-(Oxydiethylene)-2-benzothiazolesulfenamide
Cure-rite OBTS
DTXCID201096
Meramid M
CAS-102-77-2
CCRIS 4911
HSDB 2867
EINECS 203-052-4
BRN 0191684
UNII-VCD7623F3K
AI3-27134
Accelerator NC
2-(Morpholinthio)-benzothiazole
4-(2-Benzothiazolylthio)-morpholine
NOBS
OBTS
2-(4-Morpholino)thiobenzothiazole [HSDB]
EC 203-052-4
NCIOpen2_003384
SCHEMBL79658
4-27-00-01868 (Beilstein Handbook Reference)
MLS000055410
CHEMBL1530581
MHKLKWCYGIBEQF-UHFFFAOYSA-
2-morpholinosulphenyl-benzothiazole
HMS1760H22
HMS2163A20
HMS3323A19
2-(4-morpholinothio)-benzothiazole
4-(2-benzothiazolylthio)-morpholin
Tox21_110976
2-morpholin-4-ylsulfanylbenzothiazole
MFCD00022870
2-Benzothiazolesulfenamide, N-morphol
AKOS001025507
Tox21_110976_1
DB14202
2-(MORPHOLINOTHIO)-BENZOTHIAZOLE
WLN: T56 BN DSJ CS-AT6N DOTJ
BS-42257
N-Oxydiethylene-2-benzothiazolesulfenamide
SMR000066103
2-(4-Morpholinylthio)-1,3-benzothiazole
CS-0201154
FT-0608683
M0532
E78169
2-(4-Morpholinylsulfanyl)-1,3-benzothiazole #
EN300-1726082
A896704
Q-200146
BRD-K97360717-001-07-6
Q27291760
Z56821717
InChI=1/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2
N-OXYDIETHYLENE-2-BENZOTHIAZOLE-SULFENAMIDE

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a high-performance rubber accelerator widely used in the rubber industry to enhance the vulcanization process.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is recognized for its ability to improve the physical properties of rubber products, including elasticity, tensile strength, and heat resistance.
The chemical formula for N-Oxydiethylene-2-Benzothiazole-Sulfenamide is C11H14N2O2S2, and it is commonly used in various industrial applications due to its effective properties.

CAS Number: 52343-17-2
EC Number: 257-477-7

Synonyms: N-Oxydiethylene-2-benzothiazolesulfenamide, OBTS, Accelerator OBTS, N-Oxydiethylene-2-benzothiazole sulfenamide, OBTS Accelerator, 2-Benzothiazolesulfenamide, N-(2-(2-Hydroxyethoxy)ethyl)-2-benzothiazolesulfenamide, Vulcanization Accelerator OBTS, Oxydiethylene benzothiazolesulfenamide, Rubber Accelerator OBTS



APPLICATIONS


N-Oxydiethylene-2-Benzothiazole-Sulfenamide is extensively used as a primary accelerator in the vulcanization of natural and synthetic rubbers.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is particularly favored in the production of tires, offering excellent scorch safety and improved curing efficiency.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the manufacturing of industrial rubber products such as hoses, belts, and seals, enhancing their durability and flexibility.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is widely used in the production of automotive rubber components, including gaskets, weatherstrips, and vibration dampening products, ensuring optimal performance.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the formulation of rubber compounds for footwear, providing superior flexibility, wear resistance, and comfort.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is essential in the rubber industry for the production of conveyor belts, improving their tensile strength and longevity.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the creation of rubberized fabrics, offering improved elasticity and durability for industrial and consumer applications.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a key component in the manufacture of rubber-based adhesives and sealants, contributing to their strong bonding capabilities and long-term performance.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the formulation of specialty rubber compounds used in high-performance applications, ensuring consistent quality and durability.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is applied in the production of rubber products for the construction industry, such as rubber mats and protective coatings, enhancing their resistance to environmental factors.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the production of rubber sheets and films, improving their flexibility, tear resistance, and tensile strength.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the manufacturing of rubber insulation materials, providing enhanced thermal stability and resistance to aging.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is found in the production of rubber seals and O-rings, ensuring their durability and resistance to harsh environmental conditions.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the automotive industry for the production of high-performance rubber hoses, contributing to their heat resistance and long service life.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the formulation of rubber compounds for anti-vibration products, offering excellent shock absorption and resilience.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the production of specialty rubber compounds for the aerospace industry, ensuring high performance under extreme conditions.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the manufacturing of rubber components for marine applications, providing resistance to saltwater corrosion and UV exposure.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is found in the production of rubber grommets and bushings, enhancing their flexibility, wear resistance, and long-term performance.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the creation of rubber linings for industrial equipment, offering enhanced resistance to abrasion and chemical exposure.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the production of rubber components for mining applications, providing superior durability, impact resistance, and longevity.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the formulation of rubber compounds for high-pressure hydraulic seals, ensuring their long-term stability and performance under demanding conditions.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the production of rubber profiles for construction joints, providing enhanced sealing properties and durability.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the manufacturing of rubber components for railway applications, contributing to their wear resistance and durability under heavy loads.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the production of rubber components for oil and gas exploration, ensuring their performance and resistance to high-pressure environments.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is found in the formulation of rubber compounds for industrial rollers, offering improved wear resistance, load-bearing capacity, and longevity.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the creation of specialty rubber compounds for high-temperature applications, ensuring their stability and performance in extreme conditions.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a key component in the production of rubber components for heavy machinery, enhancing their durability and resistance to harsh environments.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the production of rubber components for industrial valves, offering improved sealing properties, chemical resistance, and long-term reliability.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the formulation of rubber compounds for electrical insulation, ensuring their stability, safety, and long-term performance.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the production of rubber belts and drive systems, enhancing their flexibility, load-bearing capacity, and service life.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is found in the manufacturing of rubber components for the food and beverage industry, ensuring compliance with safety standards and long-term durability.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the formulation of rubber compounds for medical applications, offering biocompatibility, sterilizability, and performance under stringent conditions.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is employed in the creation of rubber linings for storage tanks, providing resistance to chemical corrosion and long-term durability.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is utilized in the production of rubber components for agricultural machinery, offering durability, resistance to wear, and performance in demanding conditions.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is used in the formulation of rubber compounds for high-performance automotive parts, providing enhanced heat resistance, wear resistance, and overall performance.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a key ingredient in the production of rubber components for the electronics industry, ensuring their stability, durability, and long-term performance.



DESCRIPTION


N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a high-performance rubber accelerator widely used in the rubber industry to enhance the vulcanization process.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is recognized for its ability to improve the physical properties of rubber products, including elasticity, tensile strength, and heat resistance.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a versatile chemical compound used in various rubber applications.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide provides excellent scorch safety, allowing for extended processing times without compromising the quality of the final product.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is essential in the production of high-performance rubber products, contributing to their strength, resilience, and resistance to wear.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is widely used in the automotive industry, where it enhances the performance and durability of rubber components.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is also employed in the manufacturing of industrial rubber products, including hoses, seals, and gaskets, ensuring their long-term reliability and performance.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a critical accelerator in the vulcanization process, providing optimal curing and improving the overall quality of rubber compounds.

N-Oxydiethylene-2-Benzothiazole-Sulfenamide is recognized for its stability, effectiveness, and versatility in a wide range of rubber applications, from automotive components to industrial products.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is essential in the formulation of specialty rubber compounds, providing consistent performance and long-term reliability.
N-Oxydiethylene-2-Benzothiazole-Sulfenamide is a key ingredient in the production of rubber materials used in demanding environments, ensuring their resistance to extreme conditions and prolonged use.



PROPERTIES


Chemical Formula: C11H14N2O2S2
Common Name: N-Oxydiethylene-2-Benzothiazole-Sulfenamide
Molecular Structure:
Appearance: Light yellow powder
Density: 1.32 g/cm³
Melting Point: 130-135°C
Solubility: Insoluble in water; soluble in benzene, acetone, and chloroform
Flash Point: 225°C
Reactivity: Stable under normal conditions; decomposes at high temperatures
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store below 25°C in a dry, well-ventilated area
Vapor Pressure: Negligible at room temperature



FIRST AID


Inhalation:
If N-Oxydiethylene-2-Benzothiazole-Sulfenamide is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust or vapors.
Do not eat, drink, or smoke while handling N-Oxydiethylene-2-Benzothiazole-Sulfenamide.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Avoid generating dust. Sweep up and collect the material for disposal in a sealed container.

Storage:
Store N-Oxydiethylene-2-Benzothiazole-Sulfenamide in a cool, dry, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust or aerosols.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust or vapors may be present.


Storage:

Temperature:
Store N-Oxydiethylene-2-Benzothiazole-Sulfenamide at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store N-Oxydiethylene-2-Benzothiazole-Sulfenamide away from incompatible materials, including strong acids, bases, and oxidizing agents.

Handling Equipment:
Use dedicated equipment for handling N-Oxydiethylene-2-Benzothiazole-Sulfenamide to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
NP 10 ( Arkopal N 100 )
Nonylphenol 10; Nonylphenol ethoxylate; Polyethoxylate; Polyoxyethylene nonylphenol; Polyoxyethylene nonyl phenyl ether; Triton; Tergitol; 4-(2,4-dimethylheptan-3-yl)phenol; TERGITOL NP-10; Nonylphenol Ethoxylate; CAS NO: 26027-38-3
NP 13 ( Arkopal N 130)
Novoperm Bordeaux HF3R PIGMENT VIOLET 32 Novoperm Bordeaux HF3R is a blue shade benzimidazolone pigment. It exhibits excellent fastness properties. It is recommended for paste inks and for solvent- and water based packaging gravure and flexographic printing inks. Benefits Excellent fastness properties
NP 15 ( Arkopal N 150)
Novoperm Bordeaux HF3R PIGMENT VIOLET 32 Novoperm Bordeaux HF3R is a blue shade benzimidazolone pigment. It exhibits excellent fastness properties. It is recommended for paste inks and for solvent- and water based packaging gravure and flexographic printing inks. Benefits Excellent fastness properties
NP 20 ( Arkopal N 208 )
Novoperm Red BLS 02 for Paints and Coatings PIGMENT RED 48:4 Novoperm Red BLS 02 is a strong transparent manganese-laked monoazo pigment. The manganese content of this pigment can have a negative influence on the drying behavior of oxidative drying, alkyd resin systems. Benefits High weather fastness High overspray fastness High tinting strength and brilliace
NP 23 ( Arkopal N 238 )
Novoperm Red F3RK 70 for Paints and Coatings PIGMENT RED 170 Novoperm Red F3RK 70 is a blue shade, brilliant and very opaque Naphthol AS pigment. Benefits High weather fastness High overspray fastness High tinting strength and brilliace
NP 3 APEO FREE
NP 3 APEO FREE is a nonionic surfactant which can be used to extract estrogens.
NP 3 APEO FREE is phenol derivatives.
NP 3 APEO FREE are members of the alkylphenol class and primarily used to manufacture cleaning agents and surfactants due to their wetting properties.

CAS Number: 127087-87-0
Molecular Formula: C17H28O2
Molecular Weight: 264.40302
EINECS Number: 500-315-8

Synonyms: Nonoxinol, 2-(4-nonylphenoxy)ethanol, 26027-38-3, 104-35-8, 2-(p-Nonylphenoxy)ethanol, Nonoxynols, 127087-87-0, 4-Nonyl Phenol Monoethoxylate, Ethanol, 2-(4-nonylphenoxy)-, NONOXYNOL, 4-Nonylphenol-mono-ethoxylate, 68131-40-8, 4-Nonylphenol Monoethoxylate, 2-(4-nonylphenoxy)ethan-1-ol, 4-nonylphenol ethoxylate, ZMD36H3ESX, 96827-63-3, Nonidet P 40 Substitute, 4-Nonyl Phenol Monoethoxylate-d4, Nonoxynol 10, Delfen (TN), Nonoxynol 9 (USP), Type NP-7, Nonoxynol 4 (USAN), ETHYLENE GLYCOL P-NONYLPHENYL ETHER, NPEO1, Nonylphenol-1-ethoxylate, Nonoxynol 15 (USAN), Nonoxynol 30 (USAN), UNII-ZMD36H3ESX, SCHEMBL198140, 4-n-Nonylphenol-mono-ethoxylate, CHEMBL1797943, DTXSID4058601, (oxyeth-ylene) nonylphenyl ether, CHEBI:53774, 4-Nonylphenol branched ethoxylated, AKOS026749958, ETHANOL, 2-(P-NONYLPHENOXY)-, FT-0673037, NS00005486, D06490, F85204, J-001157, 4-n-Nonylphenol-mono-ethoxylate 10 microg/mL in Acetone, 4-n-Nonylphenol-mono-ethoxylate 10 microg/mL in Methanol

NP 3 APEO FREE macoromolecule comprising a branched nonyl group bonded to one of the ring positions in 2-[phenoxypoly(ethoxy)]ethanol.
A commericially available detergent, NP 3 APEO FREE is used to help crystallise proteins and extract the cytoplasmic contents of cellula culture.
NP 3 APEO FREE is are having endocrine effects and substance which is used as industrial chemicals and produced in volumes over 100 kilotons per annum in the Federal Republic of Germany.

NP 3 APEO FREE are starting substance for phenol resins but mainly for nonylphenol ethoxylates, emulsifiers with a surfactant effect.
NP 3 APEO FREE is imported and exported on a large scale, whether as feedstocks or as processed (semi-finished and final) products.
Like most environmental chemicals with endocrine effects, the NP 3 APEO FREE is aromatic compound.

NP 3 APEO FREE is a nonionic surfactant used in various industrial and commercial applications.
NP 3 APEO FREE is a type of ethoxylated alcohol made by reacting ethylene oxide with trimethylnonyl alcohol.
NP 3 APEO FREEs presence and toxicity highly arouse the public concern and Germany Authority has imposed stringent measures to control their exposure.

Increasing environmental regulations, among other factors, are motivating change in how surfactants are used.
Long a leader in surfactant manufacturing,
NP 3 APEO FREE is now at the forefront of developing alternative products that meet – or exceed – conventional surfactant performance requirements.

NP 3 APEO FREE can help meet changing global expectations and address new challenges with a diverse portfolio of effective alternatives to APE surfactants.
These surfactants meet the needs for a variety of applications, including cleaning product formulations, paints and coatings, agriculture, and emulsion polymerization.
NP 3 APEO FREE are surfactants which have an emulsifying and dispersing action, so they have good wetting, penetration, emulsification, dispertion, solubilizing and washing characteristics.

This makes them suitable for a very large variety of applications: they’ve been used for over 50 years in a wide variety of products.
In the textile industry, they are used in detergents and as a scouring, coating or waterproofing agents, in printing pastes and adhesives, and in dyeing.
The most important NP 3 APEO FREE or alkylphenol ethoxylates for the textile industry are NPEO (nonylphenol ethoxylates) and OPEO (octylphenol ethoxylates) due to their detergent properties, but there are a big family.

About 90% of the produced NP 3 APEO FREE are in fact NPEO.
NP 3 APEO FREE, is a nonionic surfactant commonly used in various industrial and research applications.
NP 3 APEO FREE belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in lotions, detergents and solubilizers.

NP 3 APEO FREE is particularly useful in protein chemistry, where it is used to solubilize and stabilize proteins, such as membrane proteins, for structural analysis techniques.
In addition, NP 3 APEO FREE has potential applications in drug delivery and other medical fields due to its ability to interact with and penetrate cell membranes.
NP 3 APEO FREE is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

NP 3 APEO FREE is used in household and industrial cleaning products due to its ability to emulsify oils and improve cleaning efficiency.
Found in shampoos, conditioners, and body washes as an emulsifier and solubilizer.
NP 3 APEO FREE is used in pesticide formulations to help disperse active ingredients evenly.

Employed in textile processing as a wetting agent and detergent.
Improves the spreadability and stability of paints and coatings.
NP 3 APEO FREE utilized in formulations to enhance the solubility of active ingredients.

May cause mild skin and eye irritation upon direct contact.
Avoid inhaling vapors or mist; use appropriate ventilation.
Not intended for ingestion; seek medical attention if ingested.

NP 3 APEO FREE use gloves and eye protection when handling the chemical.
Generally considered biodegradable, but it is always good practice to prevent large quantities from entering waterways.
Consult the MSDS for detailed safety, handling, and disposal information specific to the product.

Ensure proper labeling according to local regulations for hazardous substances.
NP 3 APEO FREE refers to a type of nonylphenol ethoxylate (NP) surfactant that is free from alkylphenol ethoxylates (APEOs), particularly those derived from nonylphenol (NP).
Does not contain NP 3 APEO FREE, reducing environmental and health risks associated with these compounds.

NP 3 APEO FREE, making it effective in a wide range of pH levels and water hardness conditions.
Retains excellent emulsifying, dispersing, and wetting properties, making it suitable for various cleaning and industrial applications.
Designed to be more biodegradable and environmentally friendly compared to traditional APEO surfactants.

NP 3 APEO FREE used in formulations for laundry detergents, dishwashing liquids, and all-purpose cleaners.
Employed in heavy-duty degreasers and surface cleaners for industrial maintenance.
NP 3 APEO FREE used in textile processing to remove natural oils, waxes, and impurities.

Improves wetting and dye penetration in textile dyeing processes.
Included as emulsifiers and solubilizers to enhance product performance and stability.
NP 3 APEO FREE used as an adjuvant in pesticide formulations to improve the distribution and adherence of active ingredients on plant surfaces.

Helps to stabilize paint formulations and improve application properties.
Enhances the performance of various coatings by improving wetting and dispersion of pigments.
Acts as a stabilizer in the emulsion polymerization process, ensuring consistent particle size and distribution.

NP 3 APEO FREE surfactants are designed to be less harmful to aquatic life and more readily biodegradable.
Meets stricter environmental regulations and standards, such as those set by the European Union's REACH regulation.
NP 3 APEO FREE use appropriate PPE, such as gloves and safety glasses, when handling surfactants to avoid skin and eye contact.

Store in a cool, dry place away from direct sunlight and sources of ignition.
In the event of a spill, contain and clean up using absorbent materials and dispose of according to local regulations.

Boiling point: 188.6℃[at 101 325 Pa]
Density: 1.04 g/mL at 20 °C
vapor pressure: 0Pa at 25℃
refractive index: n20/D 1.491(lit.)
Flash point: >230 °F
storage temp.: Store at RT.
solubility: Chloroform (Slightly), Methanol (Sparingly), Water (Sparingly)
form: Oil to Thick Oil
color: Colourless
Water Solubility: 1.104mg/L at 25℃
LogP: 5.669 at 25℃

They’re in receipts, canned foods and couches, paint and spot cleaners.
They’re in the dust in homes, blood and urine, in breast milk and in the cord blood of newborns.
Concentrations of NP 3 APEO FREE and its parent compound NPEO have been measured worldwide in surface waters, sediments, sewage, the atmosphere, aquatic organisms, and even in typical human food products.

And most disturbingly, these concentrations of NP 3 APEO FREE are on the rise.(1) The U.S.
NP 3 APEO FREE has noted rising levels of alkylphenols in water samples taken from streams and rivers throughout the U.S.
The life cycles indicate long term, continued environmental contamination.

NP 3 APEO FREE are slow to biodegrade and they tend to bioaccumulate. They also move up the food chain and ultimately to us.
Though NP 3 APEO FREE themselves are not carcinogenic, teratogenic or mutagenic, research has shown that when they do degrade, their byproducts have a higher toxicity, estrogenic activity, persistence and tendence to bioaccumulate than APEOs themselves.
They have been shown to be toxic to aquatic organisms and an endocrine disruptor in higher animals, and therefore they pose a risk to humans.

As an environmental hormone disruptor, these new NP 3 APEO FREEs can invade the human body through a variety of channels, with estrogen-like effects, and are harmful to normal hormone secretion, leading to reduced sperm count in men.
Research published in the September 2006 edition of Toxicological Sciences shows that the human placenta responds to alkylphenyls in the first trimester.
The result may be early termination of pregnancy and fetal growth defect.

NP 3 APEO FREE is part of a broader category of surfactants known as alkylphenol ethoxylates (APEs) or alkyl polyethoxylates.
Its specific properties and utility depend on the length of the polyethylene glycol chain, which can be varied to tailor the surfactant for particular applications.
Varies based on the degree of ethoxylation.

NP 3 APEO FREE typically neutral to slightly alkaline in aqueous solutions.
The temperature at which the surfactant solution becomes cloudy; this depends on the ethoxylate chain length.
Generally low to moderate viscosity, depending on concentration and temperature.

Enhances cleaning efficiency by breaking down oils and grease.
NP 3 APEO FREE is used in hard surface cleaners for kitchens and bathrooms.
Included in formulations to help lift dirt and stains from fabrics.

Generally considered biodegradable, but the rate and extent can vary.
May pose some risk to aquatic life; use caution to prevent large releases into waterways.
NP 3 APEO FREE typically low toxicity but can cause skin and eye irritation with direct contact.

Store in a cool, dry place in tightly sealed containers. Protect from direct sunlight and high temperatures.
In case of a spill, use absorbent materials to clean up and prevent the chemical from entering waterways.
Follow local regulations for the disposal of surfactants and chemical waste.

Ensure compliance with relevant regional regulations, such as REACH in Europe and TSCA in the United States.
Properly label containers with hazard information and handling instructions as per local regulations.
NP 3 APEO FREE's wide-ranging applications stem from its excellent surface-active properties.

NP 3 APEO FREE is used in formulations to break down heavy grease and oil deposits in industrial settings, such as machinery cleaning and maintenance.
Metal Cleaners: Incorporated into metal cleaning solutions to remove oils, dirt, and metalworking fluids, ensuring a clean surface for further processing or coating.
Utilized in drilling fluids and oil recovery processes to enhance the emulsification of oil in water, aiding in the extraction and transport of crude oil.

Applied in formulations for cleaning pipelines and tanks to remove residues and prevent blockages.
NP 3 APEO FREE is used in soil washing solutions to remove hydrophobic contaminants from soil, aiding in the remediation of polluted sites.
Helps in breaking down oil spills and other hydrophobic pollutants in water bodies, facilitating their removal.

Acts as a surfactant in emulsion polymerization processes, stabilizing polymer particles and improving the consistency and quality of the final product.
Added to formulations of lubricants and coolants to enhance their performance and stability, particularly in metalworking and machining processes.
NP 3 APEO FREE is used as a processing aid to improve the texture and stability of food products, ensuring even distribution of ingredients.

Included in cleaning formulations for food processing equipment to ensure hygienic conditions and prevent contamination.
NP 3 APEO FREE is used in the production of medical devices where biocompatibility and low toxicity are crucial.
Acts as an excipient in drug formulations to enhance the solubility and bioavailability of active pharmaceutical ingredients (APIs).

NP 3 APEO FREE improves the dispersion of softening agents in fabric softeners, ensuring even application and effectiveness.
Enhances the cleaning power of laundry detergents by emulsifying oils and suspending dirt, leading to better stain removal.
Provides superior grease-cutting ability in dishwashing liquids, making them more effective at cleaning greasy dishes.

Enhances the stability and consistency of water-based paints, preventing the separation of pigments and other components.
NP 3 APEO FREE is used in various coating formulations to improve wetting, spreading, and adhesion properties.
Enhances the performance of adhesives by improving their spreadability and bond strength.

NP 3 APEO FREE is used in the formulation of herbicides and pesticides to ensure even distribution and adherence to plant surfaces, enhancing their effectiveness.
Included in foliar spray formulations to improve the uptake of nutrients and protective agents by plants.
NP 3 APEO FREE is used in the pre-treatment of textiles to remove natural oils, waxes, and other impurities, preparing them for dyeing and finishing.

NP 3 APEO FREE is improves the evenness and quality of dye uptake, ensuring vibrant and consistent colors in textile products.
While generally considered biodegradable, its environmental impact depends on the specific formulation and degree of ethoxylation. Efforts should be made to minimize its release into waterways.
Ensure compliance with local and international regulations, such as the European REACH regulation and the U.S. TSCA (Toxic Substances Control Act).

When handling the NP 3 APEO FREE, use appropriate PPE such as gloves, safety glasses, and respirators if necessary.
Work in well-ventilated areas to avoid inhaling vapors or mist.
In case of a spill, contain and clean up using absorbent materials and dispose of according to local regulations.

Uses:
NP 3 APEO FREE, alpha-(4-nonylphenyl)-omega-hydroxy-, branched is a surfactant and emulsifying agent.
NP 3 APEO FREE is used as a non-ionic surface-active agent and as a dispersing agent in cosmetics.
NP 3 APEO FREE has been used in a study to assess the structural characterization and antimicrobial properties of silver nanoparticles.

NP 3 APEO FREE has also been used in a study to investigate the detection of Salmonella enterica serotype enteritidis in naturally contaminated environmental samples from integrated poultry houses.
Included in formulations for both liquid and powder detergents to enhance cleaning performance while being gentle on fabrics.
Improves grease-cutting ability and ensures thorough cleaning of dishes and utensils.

NP 3 APEO FREE is used in multi-surface cleaners for effective removal of dirt, grease, and grime.
Acts as an emulsifier and stabilizer to improve the consistency and performance of hair care products.
Provides mild cleansing and foaming properties for gentle yet effective skin cleansing.

NP 3 APEO FREE is used as a scouring agent to remove oils and impurities from fabrics before dyeing or finishing processes.
Enhances the wetting and dispersing of dyes and pigments, ensuring uniform and vibrant colors.
Helps in the formulation of pesticides by improving the dispersion and adherence of active ingredients on plant surfaces, enhancing efficacy.

Assists in the dispersion and absorption of nutrients in soil treatments.
NP 3 APEO FREE is used as a dispersing agent to stabilize pigments and improve the flow and leveling properties of paint formulations.
Enhances the adhesion and durability of coatings by improving wetting and spreading on substrates.

NP 3 APEO FREE included in formulations of cutting fluids and lubricants to improve the emulsification of oils and enhance machining operations.
Acts as a stabilizer to ensure uniform particle size and dispersion in polymer emulsions used in adhesives, coatings, and sealants.
Designed to be readily biodegradable, reducing environmental impact compared to traditional surfactants containing alkylphenol ethoxylates (APEOs).

Meets stringent environmental regulations, such as those set by REACH in the European Union, ensuring safe handling and disposal practices.
NP 3 APEO FREE use appropriate PPE, such as gloves and safety glasses, when handling surfactants to prevent skin and eye contact.
Store in a cool, dry place away from direct sunlight and heat sources to maintain stability and effectiveness.

In case of spills, contain and clean up using absorbent materials and dispose of according to local regulations to prevent environmental contamination.
NP 3 APEO FREE is used in formulations for cleaning food processing equipment and facilities to maintain hygiene and prevent contamination.
Included in sanitizing solutions for food contact surfaces to ensure safety and compliance with food safety standards.

Provides gentle cleansing while maintaining the skin's natural moisture balance.
NP 3 APEO FREE effectively removes makeup residues without drying out the skin.
Acts as an emulsifier to stabilize oil-in-water or water-in-oil formulations, improving texture and application.

NP 3 APEO FREE is used in the formulation of drilling muds to enhance lubricity and improve fluid performance in drilling operations.
Included in formulations for enhanced oil recovery (EOR) processes to improve the efficiency of oil extraction.
NP 3 APEO FREE is used in creams, ointments, and topical solutions as an emulsifier and solubilizer for active pharmaceutical ingredients (APIs).

Incorporated into medical device cleaning solutions to ensure sterility and safety.
Helps in the aggregation and settling of suspended particles in water treatment processes, aiding in purification.
NP 3 APEO FREE is used to disperse oils and contaminants in water bodies during environmental remediation efforts.

NP 3 APEO FREE is used in pulp and paper manufacturing processes for washing pulp fibers and improving paper quality.
Acts as a defoaming agent to control foam formation in papermaking.
NP 3 APEO FREE is used in formulations for cleaning automotive and aerospace components to remove oils, grease, and machining residues.

Effective in degreasing metal parts before coating or assembly.
Included in concrete admixtures to improve workability and reduce water requirements, enhancing concrete performance.
NP 3 APEO FREE is used as an emulsifier and stabilizer in sealant and adhesive formulations for improved bonding and durability.

NP 3 APEO FREE is used in cleaning solutions for electronic components and semiconductor manufacturing to remove flux residues and contaminants.
Included in formulations for stripping photoresists and other coatings from substrates in semiconductor fabrication.
Suitable for use in formulations intended for applications where biocompatibility and non-toxicity are critical, such as in cosmetics and medical devices.

Supports the development of eco-friendly products by replacing traditional APEO surfactants with safer alternatives.
Adheres to regulatory requirements and standards to ensure safe handling, disposal, and environmental impact.

Safety Profile:
NP 3 APEO FREE experimental reproductive effects.
When heated to decomposition it emits acrid smoke and irritating vapors.
Direct contact with concentrated solutions or undiluted surfactants may cause irritation to the skin and eyes.

NP 3 APEO FREE is advisable to wear gloves and safety goggles when handling.
Inhalation of vapors or mists, especially in concentrated forms or in poorly ventilated areas, may cause respiratory irritation.
Adequate ventilation is recommended during handling.

While NP 3 APEO FREE surfactants are designed to be more environmentally friendly than traditional APEO-containing surfactants, excessive discharge into waterways can still pose risks to aquatic life.
Proper disposal and adherence to environmental regulations are essential.
Some surfactants may be flammable under certain conditions.

Store away from sources of ignition and follow safety guidelines for handling flammable liquids.
Prolonged or repeated exposure to surfactants may potentially lead to adverse health effects, such as respiratory sensitization or dermatitis.
Ensure good hygiene practices and use appropriate personal protective equipment (PPE) to minimize exposure.
NP 30
NP 30 NP 30 Jump to navigationJump to search NP 30 NP 30es V.svg Names IUPAC name 4-(2,4-dimethylheptan-3-yl)phenol Other names Phenol, nonyl- Identifiers CAS Number 25154-52-3 (general class) check 104-40-5 (4-n-Nonyl phenol) check 84852-15-3 (branched 4-Nonyl phenols) check 11066-49-2 (isoNP 30s) ☒ 3D model (JSmol) Interactive image ChEMBL ChEMBL153062 ☒ ChemSpider 60628 check PubChem CID 67296 UNII 79F6A2ILP5 (general class) check I03GBV4WEL (4-n-Nonyl phenol) check JRW3Q994VG (branched 4-Nonyl phenols) check InChI[show] SMILES[show] Properties Chemical formula C15H24O Molar mass 220.35 g/mol Appearance Light yellow viscous liquid with phenolic smell [1] Density 0.953 Melting point −8 to 2 °C (18 to 36 °F; 265 to 275 K) Boiling point 293 to 297 °C (559 to 567 °F; 566 to 570 K) Solubility in water 6 mg/L (pH 7) Hazards Main hazards low level endrocrine disruptor Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references NP 30s are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail. NP 30s can come in numerous structures, all of which may be considered alkylphenols. They are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] These compounds are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and NP 30 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. NP 30 has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.[3] The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.[4][5][6] NP 30 has been found to act as an agonist of the GPER (GPR30).[7] Contents 1 Structure and basic properties 2 Production 3 Applications 4 Prevalence in the environment 4.1 Environmental hazards 5 Human health hazards 5.1 Effects in pregnant women 5.2 Effects on metabolism 5.3 Cancer 5.4 Human exposure and breakdown 5.4.1 Exposure 5.4.2 Breakdown 6 Analytics 7 Regulation 8 References Structure and basic properties NP 30s fall into the general chemical category of alkylphenols.[8] The structure of NPs may vary. The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear. A branched NP 30, 4-NP 30, is the most widely produced and marketed NP 30.[9] The mixture of NP 30 isomers is a pale yellow liquid, although the pure compounds are colorless. The NP 30s are moderately soluble in water [9] but soluble in alcohol. NP 30 arises from the environmental degradation of NP 30 ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates. NPEs are a clear to light orange color liquid. NP 30 ethoxylates are nonionic in water, which means that they have no charge. Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications. They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.[2] Production NP 30 can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates. Industrially, NP 30s are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes. This synthesis leads to a very complex mixture with diverse NP 30s.[10][11][12] Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.[4] To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.[9] Since its discovery in 1940, NP 30 production has increased exponentially, and between 100 and 500 million pounds of NP 30 are produced globally every year,[9][13] meeting the definition of High Production Volume Chemicals. NP 30s are also produced naturally in the environment. One organism, the velvet worm, produces NP 30 as a component of its defensive slime. The NP 30 coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted. It also prolongs the drying process long enough for the slime to reach its target.[14] Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free NP 30 when administered to lab animals.[8] Applications NP 30 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] It can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging. Barium and calcium salts of NP 30 are also used as heat stabilizers for polyvinyl chloride (PVC).[15] NP 30 is also often used an intermediate in the manufacture of the non-ionic surfactants NP 30 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. NP 30 and NP 30 ethoxylates are only used as components of household detergents outside of Europe.[2] Nonyl Phenol, is used in many epoxy formulations mainly in North America. Prevalence in the environment NP 30 persists in aquatic environments and is moderately bioaccumulative. It is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments. Nonbiological degradation is negligible.[3] NP 30 is partially removed during municipal wastewater treatment due to sorption to suspended solids and biotransformation.[16][17] Many products that contain NP 30 have "down-the-drain" applications, such as laundry and dish soap, so the contaminants are frequently introduced into the water supply. In sewage treatment plants, NP 30 ethoxylate degrades into NP 30, which is found in river water and sediments as well as soil and groundwater.[18] NP 30 photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years. Although the concentration of NP 30 in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.[2] A major concern is that contaminated sewage sludge is frequently recycled onto agricultural land. The degradation of NP 30 in soil depends on oxygen availability and other components in the soil. Mobility of NP 30 in soil is low.[2] Bioaccumulation is significant in water-dwelling organisms and birds, and NP 30 has been found in internal organs of certain animals at concentrations of 10 to 1,000 times greater than the surrounding environment.[3] Due to this bioaccumulation and persistence of NP 30, it has been suggested that NP 30 could be transported over long distances and have a global reach that stretches far from the site of contamination.[19] NP 30 is not persistent in air, as it is rapidly degraded by hydroxyl radicals.[3] Environmental hazards NP 30 is considered to be an endocrine disruptor due to its ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms.[4][5][6][20][21] The effect is weak because NP 30s are not very close structural mimics of estradiol, but the levels of NP 30 can be sufficiently high to compensate. Structure of the hormone estradiol and one of the NP 30s. The effects of NP 30 in the environment are most applicable to aquatic species. NP 30 can cause endocrine disruption in fish by interacting with estrogen receptors and androgen receptors. Studies report that NP 30 competitively displaces estrogen from its receptor site in rainbow trout.[22] It has much less affinity for the estrogen receptor than estrogen in trout (5 x 10−5 relative binding affinity compared to estradiol) making it 100,000 times less potent than estradiol.[22][23] NP 30 causes the feminization of aquatic organisms, decreases male fertility, and decreases survival in young fish.[2] Studies show that male fish exposed to NP 30 have lower testicular weight.[22] NP 30 can disrupt steroidogenesis in the liver. One function of endogenous estrogen in fish is to stimulate the liver to make vitellogenin, which is a phospholipoprotein.[22] Vitellogenin is released by the maturing female and sequestered by developing oocytes to produce the egg yolk.[22] Males do not normally produce vitellogenin, but when exposed to NP 30 they produce similar levels of vitellogenin to females.[22] The concentration needed to induce vitellogenin production in fish is 10 ug/L for NP in water.[22] NP 30 can also interfere with the level of FSH (follicle-stimulating hormone) being released from the pituitary gland. Concentrations of NP that inhibit reproductive development and function in fish also damages kidneys, decreases body weight, and induces stressed behavior.[24] Human health hazards Alkylphenols like NP 30 and bisphenol A have estrogenic effects in the body. They are known as xenoestrogens.[25] Estrogenic substances and other endocrine disruptors are compounds that have hormone-like effects in both wildlife and humans. Xenoestrogens usually function by binding to estrogen receptors and acting competitively against natural estrogens. NP 30 has been shown to mimic the natural hormone 17β-estradiol, and it competes with the endogeous hormone for binding with the estrogen receptors ERα and ERβ.[2] NP 30 was discovered to have hormone-like effects by accident because it contaminated other experiments in laboratories that were studying natural estrogens that were using polystyrene tubes.[8] Effects in pregnant women Subcutaneous injections of NP 30 in late pregnancy causes the expression of certain placental and uterine proteins, namely CaBP-9k, which suggest it can be transferred through the placenta to the fetus. It has also been shown to have a higher potency on the first trimester placenta than the endogenous estrogen 17β-estradiol. In addition, early prenatal exposure to low doses of NP 30 cause an increase in apoptosis (programmed cell death) in placental cells. These “low doses” ranged from 10−13-10−9 M, which is lower than what is generally found in the environment.[26] NP 30 has also been shown to affect cytokine signaling molecule secretions in the human placenta. In vitro cell cultures of human placenta during the first trimester were treated with NP 30, which increase the secretion of cytokines including interferon gamma, interleukin 4, and interleukin 10, and reduced the secretion of tumor necrosis factor alpha. This unbalanced cytokine profile at this part of pregnancy has been documented to result in implantation failure, pregnancy loss, and other complications.[26] Effects on metabolism NP 30 has been shown to act as an obesity enhancing chemical or obesogen, though it has paradoxically been shown to have anti-obesity properties.[27] Growing embryos and newborns are particularly vulnerable when exposed to NP 30 because low-doses can disrupt sensitive processes that occur during these important developmental periods.[28] Prenatal and perinatal exposure to NP 30 has been linked with developmental abnormalities in adipose tissue and therefore in metabolic hormone synthesis and release (Merrill 2011). Specifically, by acting as an estrogen mimic, NP 30 has generally been shown to interfere with hypothalamic appetite control.[27] The hypothalamus responds to the hormone leptin, which signals the feeling of fullness after eating, and NP 30 has been shown to both increase and decrease eating behavior by interfering with leptin signaling in the midbrain.[27] NP 30 has been shown mimic the action of leptin on neuropeptide Y and anorectic POMC neurons, which has an anti-obesity effect by decreasing eating behavior. This was seen when estrogen or estrogen mimics were injected into the ventromedial hypothalamus.[29] On the other hand, NP 30 has been shown to increase food intake and have obesity enhancing properties by lowering the expression of these anorexigenic neurons in the brain.[30] Additionally, NP 30 affects the expression of ghrelin: an enzyme produced by the stomach that stimulates appetite.[31] Ghrelin expression is positively regulated by estrogen signaling in the stomach, and it is also important in guiding the differentiation of stem cells into adipocytes (fat cells). Thus, acting as an estrogen mimic, prenatal and perinatal exposure to NP 30 has been shown to increase appetite and encourage the body to store fat later in life.[32] Finally, long-term exposure to NP 30 has been shown to affect insulin signaling in the liver of adult male rats.[33] Cancer NP 30 exposure has also been associated with breast cancer.[2] It has been shown to promote the proliferation of breast cancer cells, due to its agonistic activity on ERα (estrogen receptor α) in estrogen-dependent and estrogen-independent breast cancer cells. Some argue that NP 30's suggested estrogenic effect coupled with its widespread human exposure could potentially influence hormone-dependent breast cancer disease.[34] Human exposure and breakdown Exposure Diet seems the most significant source of exposure of NP 30 to humans. For example, food samples were found with concentrations ranging from 0.1 to 19.4 µg/kg in a diet survey in Germany and a daily intake for an adult were calculated to be 7.5 µg/day.[35] Another study calculated a daily intake for the more exposed group of infants in the range of 0.23-0.65 µg/ kg bodyweight/ day.[36] In Taiwan, NP 30 concentrations in food ranged from 5.8 to 235.8 µg/kg. Seafood in particular was found to have a high concentration of NP 30.[37] One study conducted in Italian women showed that NP 30 was one of the highest contaminants at a concentration of 32 ng/mL in breast milk when compared to other alkyl phenols, such as octylphenol, NP 30 monoethoxylate, and two octylphenol ethoxylates. The study also found a positive correlation between fish consumption and the concentration of NP 30 in breast milk.[37] This is a large problem because breast milk is the main source of nourishment for newborns, who are in early stages of development where hormones are very influential. Elevated levels of endocrine disruptors in breast milk have been associated with negative effects on neurological development, growth, and memory function. Drinking water does not represent a significant source of exposure in comparison to other sources such as food packing materials, cleaning products, and various skin care products. Concentrations of NP 30 in treated drinking water varied from 85 ng/L in Spain to 15 ng/L in Germany.[2] Microgram amounts of NP 30 have also been found in the saliva of patients with dental sealants.[34] Breakdown When humans orally ingest NP 30, it is rapidly absorbed in the gastrointestinal tract. The metabolic pathways involved in its degradation are thought to involve glucuronide and sulfate conjugation, and the metabolites are then concentrated in fat. There is inconsistent data on bioaccumulation in humans, but NP 30 has been shown to bioaccumulate in water-dwelling animals and birds. NP 30 is excreted in feces and in urine.[3] Analytics Since NP 30s are ubiquitous in different environmentally relevant matrices like food, drinking water and human tissue samples there are many possible analytical methods for their detection. Most common methods are the analysis with GC-MS. Also as special two-dimensional application with a GCxGC-ToF-MS.[38] Nevertheless, NP 30s are also separated via HPLC technics.[39] As the branching of the nonyl sidechain plays an important role because of their varying estrogen potential different NP 30s where synthesized and analyzed on GC-MS or GC-FID systems.[40][41][42][43] In these studies the scope was also on the enantioselective separation of different NP 30s since biological systems are usually enantioselective. Regulation The production and use of NP 30 and NP 30 ethoxylates is prohibited in the European Union due to its effects on health and the environment.[2][44] In Europe, due to environmental concerns, they also have been replaced by more expensive alcohol ethoxylates, which are less problematic for the environment due to their ability to degrade more quickly than NP 30s. The European Union has also included NP on the list of priority hazardous substances for surface water in the Water Framework Directive. They are now implementing a drastic reduction policy of NP's in surface waterways. The Environmental quality standard for NP was proposed to be 0.3 ug/l.[2] In 2013 NP 30s were registered on the REACH candidate list. In the US, the EPA set criteria which recommends that NP 30 concentration should not exceed 6.6 ug/l in fresh water and 1.7 ug/l in saltwater.[45] In order to do so, the EPA is supporting and encouraging a voluntary phase-out of NP 30 in industrial laundry detergents. Similarly, the EPA is documenting proposals for a "significant new use" rule, which would require companies to contact the EPA if they decided to add NP 30 to any new cleaning and detergent products. They also plan to do more risk assessments to ascertain the effects of NP 30 on human health and the environment. It was suggested that NP 30 could be added to the list of chemicals on the Toxic Substances Control Act of 1976, but this has yet to occur as of 2014.[3] In other Asian and South American countries NP 30 is still widely available in commercial detergents, and there is little regulation.[45] NP 30 Jump to navigationJump to search NP 30 NP 30es V.svg Names IUPAC name 4-(2,4-dimethylheptan-3-yl)phenol Other names Phenol, nonyl- Identifiers CAS Number 25154-52-3 (general class) check 104-40-5 (4-n-Nonyl phenol) check 84852-15-3 (branched 4-Nonyl phenols) check 11066-49-2 (isoNP 30s) ☒ 3D model (JSmol) Interactive image ChEMBL ChEMBL153062 ☒ ChemSpider 60628 check PubChem CID 67296 UNII 79F6A2ILP5 (general class) check I03GBV4WEL (4-n-Nonyl phenol) check JRW3Q994VG (branched 4-Nonyl phenols) check InChI[show] SMILES[show] Properties Chemical formula C15H24O Molar mass 220.35 g/mol Appearance Light yellow viscous liquid with phenolic smell [1] Density 0.953 Melting point −8 to 2 °C (18 to 36 °F; 265 to 275 K) Boiling point 293 to 297 °C (559 to 567 °F; 566 to 570 K) Solubility in water 6 mg/L (pH 7) Hazards Main hazards low level endrocrine disruptor Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references NP 30s are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail. NP 30s can come in numerous structures, all of which may be considered alkylphenols. They are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] These compounds are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and NP 30 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. NP 30 has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.[3] The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.[4][5][6] NP 30 has been found to act as an agonist of the GPER (GPR30).[7] Contents 1 Structure and basic properties 2 Production 3 Applications 4 Prevalence in the environment 4.1 Environmental hazards 5 Human health hazards 5.1 Effects in pregnant women 5.2 Effects on metabolism 5.3 Cancer 5.4 Human exposure and breakdown 5.4.1 Exposure 5.4.2 Breakdown 6 Analytics 7 Regulation 8 References Structure and basic properties NP 30s fall into the general chemical category of alkylphenols.[8] The structure of NPs may vary. The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear. A branched NP 30, 4-NP 30, is the most widely produced and marketed NP 30.[9] The mixture of NP 30 isomers is a pale yellow liquid, although the pure compounds are colorless. The NP 30s are moderately soluble in water [9] but soluble in alcohol. NP 30 arises from the environmental degradation of NP 30 ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates. NPEs are a clear to light orange color liquid. NP 30 ethoxylates are nonionic in water, which means that they have no charge. Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications. They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.[2] Production NP 30 can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates. Industrially, NP 30s are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes. This synthesis leads to a very complex mixture with diverse NP 30s.[10][11][12] Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.[4] To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.[9] Since its discovery in 1940, NP 30 production has increased exponentially, and between 100 and 500 million pounds of NP 30 are produced globally every year,[9][13] meeting the definition of High Production Volume Chemicals. NP 30s are also produced naturally in the environment. One organism, the velvet worm, produces NP 30 as a component of its defensive slime. The NP 30 coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted. It also prolongs the drying process long enough for the slime to reach its target.[14] Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free NP 30 when administered to lab animals.[8] Applications NP 30 is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] It can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging. Barium and calcium salts of NP 30 are also used as heat stabilizers for polyvinyl chloride (PVC).[15] NP 30 is also often used an intermediate in the manufacture of the non-ionic surfactants NP 30 ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. NP 30 and NP 30 ethoxylates are only used as components of household detergents outside of Europe.[2] Nonyl Phenol, is used in many epoxy formulations mainly in North America. Prevalence in the environment NP 30 persists in aquatic environments and is moderately bioaccumulative. It is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments. Nonbiological degradation is negligible.[3] NP 30 is partially removed during municipal wastewater treatment due to sorption to suspended solids and biotransformation.[16][17] Many products that contain NP 30 have "down-the-drain" applications, such as laundry and dish soap, so the contaminants are frequently introduced into the water supply. In sewage treatment plants, NP 30 ethoxylate degrades into NP 30, which is found in river water and sediments as well as soil and groundwater.[18] NP 30 photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years. Although the concentration of NP 30 in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.[2] A major concern is that contaminated sewage sludge is frequently recycled onto agricultural land. The degradation of NP 30 in soil depends on oxygen availability and other components in the soil. Mobility of NP 30 in soil is low.[2] Bioaccumulation is significant in water-dwelling organisms and birds, and NP 30 has been found in internal organs of certain animals at concentrations of 10 to 1,000 times greater than the surrounding environment.[3] Due to this bioaccumulation and persistence of NP 30, it has been suggested that NP 30 could be transported over long distances and have a global reach that stretches far from the site of contamination.[19] NP 30 is not persistent in air, as it is rapidly degraded by hydroxyl radicals.[3] Environmental hazards NP 30 is considered to be an endocrine disruptor due to its ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms.[4][5][6][20][21] The effect is weak because NP 30s are not very close structural mimics of estradiol, but the levels of NP 30 can be sufficiently high to compensate. Structure of the hormone estradiol and one of the NP 30s. The effects of NP 30 in the environment are most applicable to aquatic species. NP 30 can cause endocrine disruption in fish by interacting with estrogen receptors and androgen receptors. Studies report that NP 30 competitively displaces estrogen from its receptor site in rainbow trout.[22] It has much less affinity for the estrogen receptor than estrogen in trout (5 x 10−5 relative binding affinity compared to estradiol) making it 100,000 times less potent than estradiol.[22][23] NP 30 causes the feminization of aquatic organisms, decreases male fertility, and decreases survival in young fish.[2] Studies show that male fish exposed to NP 30 have lower testicular weight.[22] NP 30 can disrupt steroidogenesis in the liver. One function of endogenous estrogen in fish is to stimulate the liver to make vitellogenin, which is a phospholipoprotein.[22] Vitellogenin is released by the maturing female and sequestered by developing oocytes to produce the egg yolk.[22] Males do not normally produce vitellogenin, but when exposed to NP 30 they produce similar levels of vitellogenin to females.[22] The concentration needed to induce vitellogenin production in fish is 10 ug/L for NP in water.[22] NP 30 can also interfere with the level of FSH (follicle-stimulating hormone) being released from the pituitary gland. Concentrations of NP that inhibit reproductive development and function in fish also damages kidneys, decreases body weight, and induces stressed behavior.[24] Human health hazards Alkylphenols like NP 30 and bisphenol A have estrogenic effects in the body. They are known as xenoestrogens.[25] Estrogenic substances and other endocrine disruptors are compounds that have hormone-like effects in both wildlife and humans. Xenoestrogens usually function by binding to estrogen receptors and acting competitively against natural estrogens. NP 30 has been shown to mimic the natural hormone 17β-estradiol, and it competes with the endogeous hormone for binding with the estrogen receptors ERα and ERβ.[2] NP 30 was discovered to have hormone-like effects by accident because it contaminated other experiments in laboratories that were studying natural estrogens that were using polystyrene tubes.[8] Effects in pregnant women Subcutaneous injections of NP 30 in late pregnancy causes the expression of certain placental and uterine proteins, namely CaBP-9k, which suggest it can be transferred through the placenta to the fetus. It has also been shown to have a higher potency on the first trimester placenta than the endogenous estrogen 17β-estradiol. In addition, early prenatal exposure to low doses of NP 30 cause an increase in apoptosis (programmed cell death) in placental cells. These “low doses” ranged from 10−13-10−9 M, which is lower than what is generally found in the environment.[26] NP 30 has also been shown to affect cytokine signaling molecule secretions in the human placenta. In vitro cell cultures of human placenta during the first trimester were treated with NP 30, which increase the secretion of cytokines including interferon gamma, interleukin 4, and interleukin 10, and reduced the secretion of tumor necrosis factor alpha. This unbalanced cytokine profile at this part of pregnancy has been documented to result in implantation failure, pregnancy loss, and other complications.[26] Effects on metabolism NP 30 has been shown to act as an obesity enhancing chemical or obesogen, though it has paradoxically been shown to have anti-obesity properties.[27] Growing embryos and newborns are particularly vulnerable when exposed to NP 30 because low-doses can disrupt sensitive processes that occur during these important developmental periods.[28] Prenatal and perinatal exposure to NP 30 has been linked with developmental abnormalities in adipose tissue and therefore in metabolic hormone synthesis and release (Merrill 2011). Specifically, by acting as an estrogen mimic, NP 30 has generally been shown to interfere with hypothalamic appetite control.[27] The hypothalamus responds to the hormone leptin, which signals the feeling of fullness after eating, and NP 30 has been shown to both increase and decrease eating behavior by interfering with leptin signaling in the midbrain.[27] NP 30 has been shown mimic the action of leptin on neuropeptide Y and anorectic POMC neurons, which has an anti-obesity effect by decreasing eating behavior. This was seen when estrogen or estrogen mimics were injected into the ventromedial hypothalamus.[29] On the other hand, NP 30 has been shown to increase food intake and have obesity enhancing properties by lowering the expression of these anorexigenic neurons in the brain.[30] Additionally, NP 30 affects the expression of ghrelin: an enzyme produced by the stomach that stimulates appetite.[31] Ghrelin expression is positively regulated by estrogen signaling in the stomach, and it is also important in guiding the differentiation of stem cells into adipocytes (fat cells). Thus, acting as an estrogen mimic, prenatal and perinatal exposure to NP 30 has been shown to increase appetite and encourage the body to store fat later in life.[32] Finally, long-term exposure to NP 30 has been shown to affect insulin signaling in the liver of adult male rats.[33] Cancer NP 30 exposure has also been associated with breast cancer.[2] It has been shown to promote the proliferation of breast cancer cells, due to its agonistic activity on ERα (estrogen receptor α) in estrogen-dependent and estrogen-independent breast cancer cells. Some argue that NP 30's suggested estrogenic effect coupled with its widespread human exposure could potentially influence hormone-dependent breast cancer disease.[34] Human exposure and breakdown Exposure Diet seems the most significant source of exposure of NP 30 to humans. For example, food samples were found with concentrations ranging from 0.1 to 19.4 µg/kg in a diet survey in Germany and a daily intake for an adult were calculated to be 7.5 µg/day.[35] Another study calculated a daily intake for the more exposed group of infants in the range of 0.23-0.65 µg/ kg bodyweight/ day.[36] In Taiwan, NP 30 concentrations in food ranged from 5.8 to 235.8 µg/kg. Seafood in particular was found to have a high concentration of NP 30.[37] One study conducted in Italian women showed that NP 30 was one of the highest contaminants at a concentration of 32 ng/mL in breast milk when compared to other alkyl phenols, such as octylphenol, NP 30 monoethoxylate, and two octylphenol ethoxylates. The study also found a positive correlation between fish consumption and the concentration of NP 30 in breast milk.[37] This is a large problem because breast milk is the main source of nourishment for newborns, who are in early stages of development where hormones are very influential. Elevated levels of endocrine disruptors in breast milk have been associated with negative effects on neurological development, growth, and memory function. Drinking water does not represent a significant source of exposure in comparison to other sources such as
NP 30
Np 30 comprising a branched nonyl group bonded to one of the ring positions in 2-[phenoxypoly(ethoxy)]ethanol.
A commericially available detergent, Np 30 is used to help crystallise proteins and extract the cytoplasmic contents of cellula culture.
Np 30 is a nonionic surfactant which can be used to extract estrogens.

CAS: 127087-87-0
MF: C17H28O2
MW: 264.40302
EINECS: 500-315-8

Synonyms
2-ethanediyl),alpha-(4-nonylphenyl)-omega-hydroxy-poly(oxy-branched;2-ethanediyl)-poly(oxy-alpha-(4-nonylphenyl)-omega-hydroxy-poly(oxy-branched;nonyl phenoxypolyethoxylethanol;Tergitol NP-9 (NPE) Solution;Tergitol(R) NP-10;TergitolPOLYETHYLENE GLYCOL TRIMETHYLNONYL ETHER;FREE SAMPLE NCV TERGITAL TM NP 10 SURFACTANT;Poly(oxy,1,2-ethanediyl) α-(4-nonylphenyl)-omega-hydroxy- branched

NP 30, a powerful emulsifier and cleaning agent designed to tackle a wide range of industrial and household applications.
This nonylphenol-based surfactant is renowned for its exceptional emulsification and wetting properties, making Np 30 an ideal choice for various formulations where efficient mixing of oil and water-based components is essential.

Np 30 Chemical Properties
Boiling point: 188.6℃[at 101 325 Pa]
Density: 1.04 g/mL at 20 °C
Vapor pressure: 0Pa at 25℃
Refractive index: n20/D 1.491(lit.)
Fp: >230 °F
Storage temp.: Store at RT.
Solubility: Chloroform (Slightly), Methanol (Sparingly), Water (Sparingly)
Form: Oil to Thick Oil
Color: Colourless
Water Solubility: 1.104mg/L at 25℃
LogP: 5.669 at 25℃
CAS DataBase Reference: 127087-87-0
EPA Substance Registry System: Np 30 (127087-87-0)

Uses
Np 30 is a surfactant and emulsifying agent.
Np 30 is used as a non-ionic surface-active agent and as a dispersing agent in cosmetics.
Np 30 has been used in a study to assess the structural characterization and antimicrobial properties of silver nanoparticles.
Np 30 has also been used in a study to investigate the detection of Salmonella enterica serotype enteritidis in naturally contaminated environmental samples from integrated poultry houses.
NP 30 ( 70 %) Arkopal N 307
Novoperm Red F3RK 70 for Paints and Coatings PIGMENT RED 170 Novoperm Red F3RK 70 is a blue shade, brilliant and very opaque Naphthol AS pigment. Benefits High weather fastness High overspray fastness High tinting strength and brilliace
NP 30 ( 80 % ) Arkopal N 308
Novoperm Red F5RK for Paints and Coatings PIGMENT RED 170 Novoperm Red F5RK is a very strong, blue shade and semi transparent Naphthol AS pigment. Benefits High weather fastness High overspray fastness High tinting strength and brilliace
NP 30 ( Arkopal N 300)
Novoperm Yellow HR 02 PIGMENT YELLOW 83 Novoperm Yellow HR 02 is a very strong, red shade, transparent diarylide yellow pigment. It exhibits excellent light fastness properties as well as good overall fastness properties. Benefits Excellent fastness properties High tinctorial strength
NP 30 (NONYLPHENOL 30 EO)
Nonylphenol 30 EO Nonylphenol 30 EO (NP 30)s are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail. Nonylphenol 30 EO (NP 30)s can come in numerous structures, all of which may be considered alkylphenols. They are used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] These compounds are also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and Nonylphenol 30 EO (NP 30) ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. Nonylphenol 30 EO (NP 30) has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.[3] The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.[4][5][6] Nonylphenol 30 EO (NP 30) has been found to act as an agonist of the GPER (GPR30). Properties Chemical formula C15H24O Molar mass 220.35 g/mol Appearance Light yellow viscous liquid with phenolic smell [1] Density 0.953 Melting point −8 to 2 °C (18 to 36 °F; 265 to 275 K) Boiling point 293 to 297 °C (559 to 567 °F; 566 to 570 K) Solubility in water 6 mg/L (pH 7) Structure and basic properties Nonylphenol 30 EO (NP 30)s fall into the general chemical category of alkylphenols.[8] The structure of NPs may vary. The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear. A branched Nonylphenol 30 EO (NP 30), 4-Nonylphenol 30 EO (NP 30), is the most widely produced and marketed Nonylphenol 30 EO (NP 30).[9] The mixture of Nonylphenol 30 EO (NP 30) isomers is a pale yellow liquid, although the pure compounds are colorless. The Nonylphenol 30 EO (NP 30)s are moderately soluble in water [9] but soluble in alcohol. Nonylphenol 30 EO (NP 30) arises from the environmental degradation of Nonylphenol 30 EO (NP 30) ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates. NPEs are a clear to light orange color liquid. Nonylphenol 30 EO (NP 30) ethoxylates are nonionic in water, which means that they have no charge. Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications. They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.[2] Production Nonylphenol 30 EO (NP 30) can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates. Industrially, Nonylphenol 30 EO (NP 30)s are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes. This synthesis leads to a very complex mixture with diverse Nonylphenol 30 EO (NP 30)s.[10][11][12] Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.[4] To make NPEs, manufacturers treat NP with ethylene oxide under basic conditions.[9] Since its discovery in 1940, Nonylphenol 30 EO (NP 30) production has increased exponentially, and between 100 and 500 million pounds of Nonylphenol 30 EO (NP 30) are produced globally every year,[9][13] meeting the definition of High Production Volume Chemicals. Nonylphenol 30 EO (NP 30)s are also produced naturally in the environment. One organism, the velvet worm, produces Nonylphenol 30 EO (NP 30) as a component of its defensive slime. The Nonylphenol 30 EO (NP 30) coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted. It also prolongs the drying process long enough for the slime to reach its target.[14] Another surfactant called nonoxynol, which was once used as intravaginal spermicide and condom lubricant, was found to metabolize into free Nonylphenol 30 EO (NP 30) when administered to lab animals.[8] Applications Nonylphenol 30 EO (NP 30) is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.[2] It can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging. Barium and calcium salts of Nonylphenol 30 EO (NP 30) are also used as heat stabilizers for polyvinyl chloride (PVC).[15] Nonylphenol 30 EO (NP 30) is also often used an intermediate in the manufacture of the non-ionic surfactants Nonylphenol 30 EO (NP 30) ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics. Nonylphenol 30 EO (NP 30) and Nonylphenol 30 EO (NP 30) ethoxylates are only used as components of household detergents outside of Europe.[2] Nonyl Phenol, is used in many epoxy formulations mainly in North America. Prevalence in the environment Nonylphenol 30 EO (NP 30) persists in aquatic environments and is moderately bioaccumulative. It is not readily biodegradable, and it can take months or longer to degrade in surface waters, soils, and sediments. Nonbiological degradation is negligible.[3] Nonylphenol 30 EO (NP 30) is partially removed during municipal wastewater treatment due to sorption to suspended solids and biotransformation.[16][17] Many products that contain Nonylphenol 30 EO (NP 30) have "down-the-drain" applications, such as laundry and dish soap, so the contaminants are frequently introduced into the water supply. In sewage treatment plants, Nonylphenol 30 EO (NP 30) ethoxylate degrades into Nonylphenol 30 EO (NP 30), which is found in river water and sediments as well as soil and groundwater.[18] Nonylphenol 30 EO (NP 30) photodegrades in sunlight, but its half-life in sediment is estimated to be more than 60 years. Although the concentration of Nonylphenol 30 EO (NP 30) in the environment is decreasing, it is still found at concentrations of 4.1 μg/L in river waters and 1 mg/kg in sediments.[2] A major concern is that contaminated sewage sludge is frequently recycled onto agricultural land. The degradation of Nonylphenol 30 EO (NP 30) in soil depends on oxygen availability and other components in the soil. Mobility of Nonylphenol 30 EO (NP 30) in soil is low.[2] Bioaccumulation is significant in water-dwelling organisms and birds, and Nonylphenol 30 EO (NP 30) has been found in internal organs of certain animals at concentrations of 10 to 1,000 times greater than the surrounding environment.[3] Due to this bioaccumulation and persistence of Nonylphenol 30 EO (NP 30), it has been suggested that Nonylphenol 30 EO (NP 30) could be transported over long distances and have a global reach that stretches far from the site of contamination.[19] Nonylphenol 30 EO (NP 30) is not persistent in air, as it is rapidly degraded by hydroxyl radicals.[3] Environmental hazards Nonylphenol 30 EO (NP 30) is considered to be an endocrine disruptor due to its ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms.[4][5][6][20][21] The effect is weak because Nonylphenol 30 EO (NP 30)s are not very close structural mimics of estradiol, but the levels of Nonylphenol 30 EO (NP 30) can be sufficiently high to compensate. Structure of the hormone estradiol and one of the Nonylphenol 30 EO (NP 30)s. The effects of Nonylphenol 30 EO (NP 30) in the environment are most applicable to aquatic species. Nonylphenol 30 EO (NP 30) can cause endocrine disruption in fish by interacting with estrogen receptors and androgen receptors. Studies report that Nonylphenol 30 EO (NP 30) competitively displaces estrogen from its receptor site in rainbow trout.[22] It has much less affinity for the estrogen receptor than estrogen in trout (5 x 10−5 relative binding affinity compared to estradiol) making it 100,000 times less potent than estradiol.[22][23] Nonylphenol 30 EO (NP 30) causes the feminization of aquatic organisms, decreases male fertility, and decreases survival in young fish.[2] Studies show that male fish exposed to Nonylphenol 30 EO (NP 30) have lower testicular weight.[22] Nonylphenol 30 EO (NP 30) can disrupt steroidogenesis in the liver. One function of endogenous estrogen in fish is to stimulate the liver to make vitellogenin, which is a phospholipoprotein.[22] Vitellogenin is released by the maturing female and sequestered by developing oocytes to produce the egg yolk.[22] Males do not normally produce vitellogenin, but when exposed to Nonylphenol 30 EO (NP 30) they produce similar levels of vitellogenin to females.[22] The concentration needed to induce vitellogenin production in fish is 10 ug/L for NP in water.[22] Nonylphenol 30 EO (NP 30) can also interfere with the level of FSH (follicle-stimulating hormone) being released from the pituitary gland. Concentrations of NP that inhibit reproductive development and function in fish also damages kidneys, decreases body weight, and induces stressed behavior.[24] Human health hazards Alkylphenols like Nonylphenol 30 EO (NP 30) and bisphenol A have estrogenic effects in the body. They are known as xenoestrogens.[25] Estrogenic substances and other endocrine disruptors are compounds that have hormone-like effects in both wildlife and humans. Xenoestrogens usually function by binding to estrogen receptors and acting competitively against natural estrogens. Nonylphenol 30 EO (NP 30) has been shown to mimic the natural hormone 17β-estradiol, and it competes with the endogeous hormone for binding with the estrogen receptors ERα and ERβ.[2] Nonylphenol 30 EO (NP 30) was discovered to have hormone-like effects by accident because it contaminated other experiments in laboratories that were studying natural estrogens that were using polystyrene tubes.[8] Effects in pregnant women Subcutaneous injections of Nonylphenol 30 EO (NP 30) in late pregnancy causes the expression of certain placental and uterine proteins, namely CaBP-9k, which suggest it can be transferred through the placenta to the fetus. It has also been shown to have a higher potency on the first trimester placenta than the endogenous estrogen 17β-estradiol. In addition, early prenatal exposure to low doses of Nonylphenol 30 EO (NP 30) cause an increase in apoptosis (programmed cell death) in placental cells. These “low doses” ranged from 10−13-10−9 M, which is lower than what is generally found in the environment.[26] Nonylphenol 30 EO (NP 30) has also been shown to affect cytokine signaling molecule secretions in the human placenta. In vitro cell cultures of human placenta during the first trimester were treated with Nonylphenol 30 EO (NP 30), which increase the secretion of cytokines including interferon gamma, interleukin 4, and interleukin 10, and reduced the secretion of tumor necrosis factor alpha. This unbalanced cytokine profile at this part of pregnancy has been documented to result in implantation failure, pregnancy loss, and other complications.[26] Effects on metabolism Nonylphenol 30 EO (NP 30) has been shown to act as an obesity enhancing chemical or obesogen, though it has paradoxically been shown to have anti-obesity properties.[27] Growing embryos and newborns are particularly vulnerable when exposed to Nonylphenol 30 EO (NP 30) because low-doses can disrupt sensitive processes that occur during these important developmental periods.[28] Prenatal and perinatal exposure to Nonylphenol 30 EO (NP 30) has been linked with developmental abnormalities in adipose tissue and therefore in metabolic hormone synthesis and release (Merrill 2011). Specifically, by acting as an estrogen mimic, Nonylphenol 30 EO (NP 30) has generally been shown to interfere with hypothalamic appetite control.[27] The hypothalamus responds to the hormone leptin, which signals the feeling of fullness after eating, and Nonylphenol 30 EO (NP 30) has been shown to both increase and decrease eating behavior by interfering with leptin signaling in the midbrain.[27] Nonylphenol 30 EO (NP 30) has been shown mimic the action of leptin on neuropeptide Y and anorectic POMC neurons, which has an anti-obesity effect by decreasing eating behavior. This was seen when estrogen or estrogen mimics were injected into the ventromedial hypothalamus.[29] On the other hand, Nonylphenol 30 EO (NP 30) has been shown to increase food intake and have obesity enhancing properties by lowering the expression of these anorexigenic neurons in the brain.[30] Additionally, Nonylphenol 30 EO (NP 30) affects the expression of ghrelin: an enzyme produced by the stomach that stimulates appetite.[31] Ghrelin expression is positively regulated by estrogen signaling in the stomach, and it is also important in guiding the differentiation of stem cells into adipocytes (fat cells). Thus, acting as an estrogen mimic, prenatal and perinatal exposure to Nonylphenol 30 EO (NP 30) has been shown to increase appetite and encourage the body to store fat later in life.[32] Finally, long-term exposure to Nonylphenol 30 EO (NP 30) has been shown to affect insulin signaling in the liver of adult male rats.[33] Cancer Nonylphenol 30 EO (NP 30) exposure has also been associated with breast cancer.[2] It has been shown to promote the proliferation of breast cancer cells, due to its agonistic activity on ERα (estrogen receptor α) in estrogen-dependent and estrogen-independent breast cancer cells. Some argue that Nonylphenol 30 EO (NP 30)'s suggested estrogenic effect coupled with its widespread human exposure could potentially influence hormone-dependent breast cancer disease.[34] Human exposure and breakdown Exposure Diet seems the most significant source of exposure of Nonylphenol 30 EO (NP 30) to humans. For example, food samples were found with concentrations ranging from 0.1 to 19.4 µg/kg in a diet survey in Germany and a daily intake for an adult were calculated to be 7.5 µg/day.[35] Another study calculated a daily intake for the more exposed group of infants in the range of 0.23-0.65 µg/ kg bodyweight/ day.[36] In Taiwan, Nonylphenol 30 EO (NP 30) concentrations in food ranged from 5.8 to 235.8 µg/kg. Seafood in particular was found to have a high concentration of Nonylphenol 30 EO (NP 30).[37] One study conducted in Italian women showed that Nonylphenol 30 EO (NP 30) was one of the highest contaminants at a concentration of 32 ng/mL in breast milk when compared to other alkyl phenols, such as octylphenol, Nonylphenol 30 EO (NP 30) monoethoxylate, and two octylphenol ethoxylates. The study also found a positive correlation between fish consumption and the concentration of Nonylphenol 30 EO (NP 30) in breast milk.[37] This is a large problem because breast milk is the main source of nourishment for newborns, who are in early stages of development where hormones are very influential. Elevated levels of endocrine disruptors in breast milk have been associated with negative effects on neurological development, growth, and memory function. Drinking water does not represent a significant source of exposure in comparison to other sources such as food packing materials, cleaning products, and various skin care products. Concentrations of Nonylphenol 30 EO (NP 30) in treated drinking water varied from 85 ng/L in Spain to 15 ng/L in Germany.[2] Microgram amounts of Nonylphenol 30 EO (NP 30) have also been found in the saliva of patients with dental sealants.[34] Breakdown When humans orally ingest Nonylphenol 30 EO (NP 30), it is rapidly absorbed in the gastrointestinal tract. The metabolic pathways involved in its degradation are thought to involve glucuronide and sulfate conjugation, and the metabolites are then concentrated in fat. There is inconsistent data on bioaccumulation in humans, but Nonylphenol 30 EO (NP 30) has been shown to bioaccumulate in water-dwelling animals and birds. Nonylphenol 30 EO (NP 30) is excreted in feces and in urine.[3] Analytics Since Nonylphenol 30 EO (NP 30)s are ubiquitous in different environmentally relevant matrices like food, drinking water and human tissue samples there are many possible analytical methods for their detection. Most common methods are the analysis with GC-MS. Also as special two-dimensional application with a GCxGC-ToF-MS.[38] Nevertheless, Nonylphenol 30 EO (NP 30)s are also separated via HPLC technics.[39] As the branching of the nonyl sidechain plays an important role because of their varying estrogen potential different Nonylphenol 30 EO (NP 30)s where synthesized and analyzed on GC-MS or GC-FID systems.[40][41][42][43] In these studies the scope was also on the enantioselective separation of different Nonylphenol 30 EO (NP 30)s since biological systems are usually enantioselective. Regulation The production and use of Nonylphenol 30 EO (NP 30) and Nonylphenol 30 EO (NP 30) ethoxylates is prohibited in the European Union due to its effects on health and the environment.[2][44] In Europe, due to environmental concerns, they also have been replaced by more expensive alcohol ethoxylates, which are less problematic for the environment due to their ability to degrade more quickly than Nonylphenol 30 EO (NP 30)s. The European Union has also included NP on the list of priority hazardous substances for surface water in the Water Framework Directive. They are now implementing a drastic reduction policy of NP's in surface waterways. The Environmental quality standard for NP was proposed to be 0.3 ug/l.[2] In 2013 Nonylphenol 30 EO (NP 30)s were registered on the REACH candidate list. In the US, the EPA set criteria which recommends that Nonylphenol 30 EO (NP 30) concentration should not exceed 6.6 ug/l in fresh water and 1.7 ug/l in saltwater.[45] In order to do so, the EPA is supporting and encouraging a voluntary phase-out of Nonylphenol 30 EO (NP 30) in industrial laundry detergents. Similarly, the EPA is documenting proposals for a "significant new use" rule, which would require companies to contact the EPA if they decided to add Nonylphenol 30 EO (NP 30) to any new cleaning and detergent products. They also plan to do more risk assessments to ascertain the effects of Nonylphenol 30 EO (NP 30) on human health and the environment. It was suggested that Nonylphenol 30 EO (NP 30) could be added to the list of chemicals on the Toxic Substances Control Act of 1976, but this has yet to occur as of 2014.[3] In other Asian and South American countries Nonylphenol 30 EO (NP 30) is still widely available in commercial detergents, and there is little regulation. Uses Nonylphenol 30 EO (NP 30) is an alkylphenol and together with its derivatives, such as trisnonylphenol phosphite (TNP) and nonylphenol polyethoxylates (NPnEO), they are used as additives in the plastic industry, e.g., in polypropylene where nonylphenol ethoxylates are used as hydrophilic surface modifiers or as stabilizer during crystallization of polypropylene to enhance their mechanical properties. They are also used as antioxidant, antistatic agents, and plasticizer in polymers, and as stabilizer in plastic food packaging materials. Uses In the preparation of lubricating oil additives, resins, plasticizers, surface active agents. Uses Principal use as an intermediate in the production of nonionic ethoxylated surfactants; as an intermediate in the manufacture of phosphite antioxidants used for the plastics and rubber industries Definition A mixture of isomeric monoalkyl phenols, predominantly p-substituted. General Description A thick, yellowish liquid with a slight phenolic odor. Insoluble in water. Flash point 285°F. Burns although difficult to ignite. May irritate the skin. Used in the manufacture of oil additives, surfactants, fungicide preparations and plastics and rubber. Air & Water Reactions Insoluble in water. Reactivity Profile Nonylphenol 30 EO behaves as a very weak organic acid. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Likely to react exothermically with concentrated sulfuric acid and nitric acid. Health Hazard Moderately toxic if swallowed. Severely irritating to skin and eyes. Fire Hazard Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Chemical Reactivity Reactivity with Water: No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. Nonylphenol is a toxic xenobiotic compound classified as an endocrine disrupter capable of interfering with the hormonal system of numerous organisms. It originates principally from the degradation of nonylphenol ethoxylates which are widely used as industrial surfactants. Nonylphenol ethoxylates reach sewage treatment works in substantial quantities where they biodegrade into several by-products including nonylphenol. Due to its physical–chemical characteristics, such as low solubility and high hydrophobicity, nonylphenol accumulates in environmental compartments that are characterised by high organic content, typically sewage sludge and river sediments, where it persists. The occurrence of nonylphenol in the environment is clearly correlated with anthropogenic activities such as wastewater treatment, landfilling and sewage sludge recycling. Nonylphenol is found often in matrices such as sewage sludge, effluents from sewage treatment works, river water and sediments, soil and groundwater. The impacts of nonylphenol in the environment include feminization of aquatic organisms, decrease in male fertility and the survival of juveniles at concentrations as low as 8.2 μg/l. Due to the harmful effects of the degradation products of nonylphenol ethoxylates in the environment, the use and production of such compounds have been banned in EU countries and strictly monitored in many other countries such as Canada and Japan. Although it has been shown that the concentration of nonylphenol in the environment is decreasing, it is still found at concentrations of 4.1 μg/l in river waters and 1 mg/kg in sediments. Nonylphenol has been referred to in the list of priority substances in the Water Frame Directive and in the 3rd draft Working Document on Sludge of the EU. Consequently there is currently a concern within some industries about the possibility of future regulations that may impose the removal of trace contaminants from contaminated effluents. The significance of upgrading sewage treatment works with advanced treatment technologies for removal of trace contaminants is discussed. Alkylphenols are weak estrogenic environmental contaminants and have been implicated in the disruption of endocrine function in wildlife. The influence of biotransformation, tissue distribution, and elimination on biological activity was investigated in juvenile rainbow trout following a single iv dose of [(3)H]Nonylphenol 30 EO (NP 30). Distribution and elimination of [(3)H]Nonylphenol 30 EO (NP 30) residues in tissues sampled 1, 2, 4, 24, 48, 72, and 144 hr after dosing was determined by sample combustion and liquid scintillation counting (LSC). Total 3H-labeled residue concentrations in trout 144 hr after dosing were in order: bile >> feces >> liver > pyloric caeca > kidney > brain, gill, gonad, heart, plasma, skeletal muscle, and skin. The depletion kinetics of [(3)H]residues from tissues and plasma was biphasic with prolonged beta-phase half-lives in muscle and liver of 99 hr. Radio-HPLC analysis of metabolites in bile, liver, pyloric caeca, and feces samples demonstrated similar profiles and contrasted with muscle where only parent compound was found. The predominant metabolite in bile was a glucuronide conjugate of Nonylphenol 30 EO (NP 30). Other metabolites included glucuronide conjugates of ring or side chain hydroxylated Nonylphenol 30 EO (NP 30). Liver contained a low level (1.7%) of covalently bound residues. Metabolism studies using isolated trout hepatocytes produced a similar range of metabolites and a sulfate conjugate of hydroxylated Nonylphenol 30 EO (NP 30). Despite rapid metabolism and excretion, a substantial depot of parent compound remained in muscle which will have implications for the maintenance of Nonylphenol 30 EO (NP 30) residues and associated biological activity. IDENTIFICATION: Nonylphenol 30 EO (NP 30) is a thick, yellow liquid. It is very slightly to insoluble in water. USE: Nonylphenol 30 EO (NP 30) is used to make lubricating oil additives, resins, plasticizers, fungicides, rubbers and plastics. These products are used in industry, agriculture and in the home. Household products containing Nonylphenol 30 EO (NP 30) include food packaging and rubber items intended for repeated use in contact with food . Nonylphenol 30 EO (NP 30) is a mixture component of nonylphenol which is present in many household maintenance products such as epoxy. Nonylphenols are being phased out of use in consumer products. EXPOSURE: Workers that use Nonylphenol 30 EO (NP 30) may breathe in vapors or have direct skin contact. The general population may be exposed by ingestion of or dermal contact with contaminated water and dermal contact with products containing this compound. Nonylphenol 30 EO (NP 30) has been detected in human breast milk, blood and urine. If Nonylphenol 30 EO (NP 30) is released to the environment, it will be very persistent. It will be broken down in air but is not expected to be broken down by sunlight. It will move slowly into air from moist soil and water surfaces. It is not expected to move through soil. It will be broken down by microorganisms and is expected to build up in fish, animals and humans. RISK: Altered function has been observed in human immune cells exposed to Nonylphenol 30 EO (NP 30) in a laboratory setting. These studies suggest that exposure to Nonylphenol 30 EO (NP 30) may increase the risk of autoimmune diseases, where the body's immune system attacks healthy cells, such as inflammatory bowel disease. However, there are no studies evaluating potential associations between Nonylphenol 30 EO (NP 30) exposure levels in humans and immune function. No additional data on the potential toxic effects of Nonylphenol 30 EO (NP 30) in humans were available. Severe eye damage was observed in laboratory animals following direct exposure. Increased immune responses to known allergens were observed in laboratory animals exposed to Nonylphenol 30 EO (NP 30) via injection, indicating that Nonylphenol 30 EO (NP 30) may aggravate allergic diseases. Data on the potential for Nonylphenol 30 EO (NP 30) to cause infertility, abortion, or birth defects were not available. However, risk factors for obesity (increases in body weight, fat mass and serum cholesterol) were observed in both first and second generation offspring of laboratory animals exposed to oral doses of Nonylphenol 30 EO (NP 30) during pregnancy only. Obesity risk factors were also observed in young laboratory animals directly exposed to Nonylphenol 30 EO (NP 30) via injection. Data on the potential for Nonylphenol 30 EO (NP 30) to cause cancer in laboratory animals were not available. The potential for Nonylphenol 30 EO (NP 30) to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. The two commercial purity grades of Nonylphenol 30 EO (NP 30) are a technical grade which is composed of 10-12% 2-nonylphenol, 85-90% Nonylphenol 30 EO (NP 30), and up to 5% 2,4-dinonylphenol, and a high purity grade which contains 5% maximum 2-nonylphenol, 95% minimum Nonylphenol 30 EO (NP 30), and only a trace of 2,4-dinonylphenol. A method for the determination of alkylphenols in food using cold solvent extraction with methanol, followed by a two-stage chromatographic purification and GC-MS analysis, was developed. The method was validated and used to measure concentrations of 4-octylphenol and Nonylphenol 30 EO (NP 30) congener totals in UK duplicate diet samples. Individual 4-n-octylphenol and 4-n-nonylphenol congeners were also measured, although these were not detected in any sample. Only one sample showed 4-tert-octylphenol at 8.7 ug/kg, but levels of Nonylphenol 30 EO (NP 30) ranged from not detectable (<3.8 ug/kg) to 25 ug/kg. This concentration range is lower than that reported by others. Tests carried out on the stability of the octyl- and nonylphenol congeners in a duplicate diet matrix over 6 months suggest that some analyte depletion might have occurred during extended frozen storage, which in part may account for the relatively lower concentrations detected, although the extent of usage of these compounds also needs to be taken into consideration. A novel hyphenated method based on ultrasound-assisted dispersive liquid-liquid microextraction coupled to precolumn derivatization has been established for the simultaneous determination of bisphenol A, 4-octylphenol, and Nonylphenol 30 EO (NP 30) by high-performance liquid chromatography with fluorescence detection. Different parameters that influence microextraction and derivatization have been optimized. The quantitative linear range of analytes is 5.0-400.0 ng/L, and the correlation coefficients are more than 0.9998. Limits of detection for soft drinks and dairy products have been obtained in the range of 0.5-1.2 ng/kg and 0.01-0.04 ug/kg, respectively. Relative standard deviations of intra- and inter-day precision for retention time and peak area are in the range of 0.47-2.31 and 2.76-8.79%, respectively. Accuracy is satisfactory in the range of 81.5-118.7%. Relative standard deviations of repeatability are in the range of 0.35-1.43 and 2.36-4.75% for retention time and peak area, respectively. Enrichment factors for bisphenol A, 4-octylphenol, and Nonylphenol 30 EO (NP 30) are 170.5, 240.3, and 283.2, respectively. The results of recovery and matrix effect are in the range of 82.7-114.9 and 92.0-109.0%, respectively. The proposed method has been applied to the determination of bisphenol A, 4-octylphenol, and Nonylphenol 30 EO (NP 30) in soft drinks and dairy products with much higher sensitivity than many other methods. The pressurized liquid extraction (PLE) of Nonylphenol 30 EO (NP 30) (4-NP) with methanol (100 degrees C and 100 atm) from river sediments was compared with methanolic Soxhlet extraction, the standard method for the sediment analysis. The PLE method showed a precision (average RSD ranged from 6 to 33%) and an accuracy (average recovery 85 and 87% for 4-NP and 4-NPE, respectively) comparable to those of Soxhlet. The extraction was performed on river sediments and no organic carbon content influence was found. The comparative study presented in this paper demonstrates that PLE is an alternative suitable extraction method for Nonylphenol 30 EO (NP 30) and Nonylphenol 30 EO (NP 30) ethoxylate determination in sediments. By the combination of solid-phase extraction as well as isotope dilution gas chromatography with mass spectrometry, a sensitive and reliable method for the determination of endocrine-disrupting chemicals including bisphenol A, 4-octylphenol, and Nonylphenol 30 EO (NP 30) in vegetable oils was established. The application of a silica/N-(n-propyl)ethylenediamine mixed solid-phase extraction cartridge achieved relatively low matrix effects for bisphenol A, 4-octylphenol, and Nonylphenol 30 EO (NP 30) in vegetable oils. Experiments were designed to evaluate the effects of derivatization, and the extraction parameters were optimized. The estimated limits of detection and quantification for bisphenol A, 4-octylphenol, and Nonylphenol 30 EO (NP 30) were 0.83 and 2.5 ug/kg, respectively. In a spiked experiment in vegetable oils, the recovery of the added bisphenol A was 97.5-110.3%, recovery of the added 4-octylphenol was 64.4-87.4%, and that of Nonylphenol 30 EO (NP 30) was 68.2-89.3%. This sensitive method was then applied to real vegetable oil samples from Zhejiang Province of China, and none of the target compounds were detected.
NP 4
What is NP 4?

NP 4 is an oil-soluble surfactant with excellent emulsification properties at low HLB (HLB: 8.9)

NP 4 is a Nonyl Phenol Ethoxylate (NPE) Surfactant.

*The usage of NP 4 should always be discussed with local authorities.

Synonyms: Nonylphenol ethoxylate (NPE); NPE; APEO; Alkyl Phenol Ethoxylate; 4-Nonylphenol branched, ethoxylated; Nonylphenol branched, ethoxylated; Nonyl phenol polyglycol ether; Nonyl Phenol Ethoxylate; Nonylphenol Ethoxylate; 4 Nonyl Phenol Ethoxylate; Nonylphenol ethoxylate; Nonylphenol, ethoxylated; Nonylphenolethoxylat; Nonylphenolethoxylate; Nonylphenylpolyethylenglykol; Nonylphénylpolyéthylèneglycol; Tergitol NP 4, Arkopal N 40; NP-4; NP4;


CAS number: 9016-45-9


NP 4 is a nonionic surfactant that decreases the surface or interfacial tension between two liquids.

NP 4 is used in Private households and in many different industries.

NP 4 is a non-ionic surface active agent for use in paints and coatings, paper and textile processing, cleaners and detergents, agrochemicals, and metalworking fluids, with excellent detergency, outstanding wetting, versatile solubility characteristics, and exceptional handling properties.


NP 4 is used in large quantities as detergents and cleaning agents but also as emulsifiers, wetting agents, foaming agents, antistatic additives, or dispersants.

NP 4 Surface Active Agent can be used in oilfield drilling and production formulations as a dispersant for petroleum oil, in-process cleaning, cleaners and degreasers, and dry cleaning.

NP 4 is a nonionic surface active agent compatible with all other nonionic, anionic, or cationic substances.

Electrolytes, for example, neutral salts, alkalis, and – to a lesser extent – acids, reduce the water solubility of NP 4 and may lead to their salting out, especially at high concentrations and temperatures


NP 4 has excellent resistance to compounds that cause hard water to metal salts, including those of heavy metals, acids, alkalis, reductive agents, and oxidative agents based on peroxide.


Emulsifying action of NP 4: The excellent emulsifying action of NP 4 allows the preparation of stable emulsions.

NP 4 is the most suitable for the various oils and solvents:
NP 4 is ideal for mineral oils, petrolatum, and similar aliphatic hydrocarbons


*Application Areas of NP 4:

Agrochemicals
Cosmetics
Detergents
I&I
Metal Working
Paints and Coatings
Pesticides & Biocides
Pulp & Paper
Textiles & Leather

*Please check local and international regulations


Uses of NP 4:
Cleaning product formulations
Paints and coatings
Emulsion polymerization
Anywhere there is a need for increased surface activity


Benefits of NP 4:
Deliver a combination of economy and performance
Excellent detergency and wetting
Good solubilization and emulsification


Properties
Application Benefits

Compatibility: NP 4 is compatible with Quats


Product Use and Formulating
Bleach Stable: Not Recommended


Typical Properties of NP 4:

% Actives: 100 %

Active substance content: about 100 %

Appearance at 20 °C: viscous, slightly yellow liquid

Chemistry: Alkylphenol Ethoxylate (APE)

pH value (DIN EN 1262), 5 % as is in ethanol/water 1:1: about 6 – 8

Solubility at 20 °C in water: insoluble

Density (DIN 51757) at 50 °C: about 1.0 g/cm³

Viscosity (DIN 53015) at 50 °C: about 43 mPas

Cloud Point °C @1% Aqueous (ASTM D 2024): Insoluble

Cloud point (EN 1890): about 36 – 38 °C (5 g in 25 g 25 % BDG solution)

CMC (25°C) ppm: Insoluble PPM

Foam Height mm - Initial (0.1 wt% actives): Insoluble

Form: Liquid

HLB: 8.9

Moles EO: 4

Pour Point: -28 °C

Pour point (DIN/ISO 3016): < -10°C

Flashpoint (DIN/ISO 2592): ca. 220 °C

Lime-soap dispersion action (DIN 53903): --- (insoluble)

Surface tension (DIN 53914) at 20 °C: --- (insoluble)



Nonylphenol (NP) and nonylphenol ethoxylates (NPEs) are produced in large volumes, with uses that lead to widespread release to the aquatic environment.

NP is persistent in the aquatic environment, moderately bioaccumulative, and highly toxic to aquatic organisms.

NP’s primary use is in the manufacture of NPEs.

NPEs are nonionic surfactants that are used in a wide variety of industrial applications and consumer products.

NPEs, though less toxic than NP, are also highly toxic to aquatic organisms and, in the environment, degrade to more environmentally persistent NP.

NPEs were once commonly used in household laundry detergents.

EPA and the detergent manufacturers have cooperated to eliminate this use.
However, NPEs are still widely used in large quantities in industrial laundry detergents and have additional uses that lead to release into water.

Therefore, EPA intends to initiate action to address its concerns about potential ecological effects due to the manufacturing, processing, distribution in commerce, and uses of NP and NPEs.
Additionally, EPA continues to have some concerns about potential risks to human health.

EPA anticipates that the actions in this Action Plan will further reduce human exposure, thereby reducing concerns associated with NP and NPEs.








NP 4 ( Arkopal N 040 )
Nonylphenol ethoxylate with 10 EO; About 100 %; Liquid; Cloud point : 62 – 65 (1) ; HLB : About 13
NP 40 ( Arkopal N 407)
Nonylphenol ethoxylate with 13 EO ; About 100 %; Liquid paste; Cloud point : 83 – 86 (1); HLB : About 14
NP 6 ( Arkopal N 060)
Nonylphenol ethoxylate with 15 EO; About 100 % Pasty 92 – 95 (1); 61 – 63 (3); HLB : About 15
NP 8 ( Arkopal N 080)
Arkopal N 208; Nonylphenol ethoxylate with 20 EO; About 80 %; Liquid; Cloud point : 70 – 73 (3); HLB : About 16
NP 9 ( Arkopal N 090)
Nonylphenol ethoxylate with 23 EO; About 80 %; Liquid; Cloud point : 73 – 75 (3) ; HLB: About 16
NP-10 (NONYL PHENOL)
DESCRIPTION:

NP-10 (Nonyl phenol) is an alkyl sulphate belonging to the group of anionic surfactants
NP-10 (Nonyl phenol) is based on natural raw materials.
NP-10 (Nonyl phenol) is dedicated mainly for cosmetic applications.


CAS NUMBER: 26027-38-3

EC NUMBER: 212-175-2

MOLECULAR FORMULA: C9H19C6H4 (OCH2CH2) NOH



DESCRIPTION:

NP-10 (Nonyl phenol) is a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.
NP-10 (Nonyl phenol) can come in numerous structures, all of which may be considered alkylphenols.
NP-10 (Nonyl phenol) is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
NP-10 (Nonyl phenol) is also precursors to the commercially important non-ionic surfactants alkylphenol ethoxylates and nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.

NP-10 (Nonyl phenol) has attracted attention due to its prevalence in the environment and its potential role as an endocrine disruptor and xenoestrogen, due to its ability to act with estrogen-like activity.
The estrogenicity and biodegradation heavily depends on the branching of the nonyl sidechain.
NP-10 (Nonyl phenol) has been found to act as an agonist of the GPER (GPR30).
NP-10 (Nonyl phenol) is compounds in the alkylphenols chemical class.

The structure of NP-10 (Nonyl phenol) can vary.
NP-10 (Nonyl phenol) can be attached to the phenol ring at various positions, often at the 4 or 2 position.
NP-10 (Nonyl phenol) can be branched or linear.
Branched nonylphenol, 4-nonylphenol, is the most commonly produced and marketed nonylphenol.
Although pure NP-10 (Nonyl phenol) is colorless, the mixture of nonylphenol isomers is a light yellow liquid.
NP-10 (Nonyl phenol) is moderately soluble in water but soluble in alcohol.

NP-10 (Nonyl phenol) arises from the environmental degradation of nonylphenol ethoxylates, which are metabolites of commercial detergents called alkylphenol ethoxylates.
NP-10 (Nonyl phenol) is clear light orange colored liquids.
NP-10 (Nonyl phenol) is non-ionic in water, they have no charge.
Due to these properties, they are used in the synthesis of detergents, cleaners, emulsifiers and various other products.

They are amphipathic (having both hydrophilic and hydrophobic properties), which allows them to envelop non-polar substances such as oil and grease and isolate them from water.
NP-10 (Nonyl phenol) is used as additives in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
NP-10 (Nonyl phenol) is also precursors of alkylphenol ethoxylates and nonylphenol ethoxylates, which are commercially important nonionic surfactants used in detergents, paints, pesticides, personal care products and plastics.

NP-10 (Nonyl phenol) has been observed to act as an endocrine system disruptor and xenoestrogen due to its excess in the environment and its ability to act with estrogen-like activity.
Estrogenicity and biodegradation are largely dependent on the branching of the nonyl side chain.
In the agricultural field, NP-10 (Nonyl phenol) is used with colophon resin during adhesive production, as it reduces surface tension and acts as a good wetting agent.
NP-10 (Nonyl phenol) is forbidden to be used in the EU because its biological solubility is very low and does not decompose in nature.
NP-10 (Nonyl phenol) is used as an additive in formulations in many sectors, especially shampoo and soap.

NP-10 (Nonyl phenol) tends to dissolve in both aqueous phase and oil and reduce the surface tension of liquids.
NP-10 (Nonyl phenol) does not form any ions when dissolved in water.
They foam less compared to anion active substances.
NP-10 (Nonyl phenol) is a versatile chemical compound widely used as a nonionic surfactant in cleaning products, detergents, and industrial cleaners.
NP-10 (Nonyl phenol)'s emulsifying properties make it valuable in textiles for color enhancement, while its solubilizing capabilities aid in agricultural formulations for improved pesticide effectiveness.

NP-10 (Nonyl phenol) is a Nonylphenol Ethoxylate based wetting agent and surfactant.
NP-10 (Nonyl phenol) is not ionic.
NP-10 (Nonyl phenol) has high rinseability feature.
NP-10 (Nonyl phenol) has a low odor profile.
NP-10 (Nonyl phenol) is soluble in water and chlorinated solvents and most polar solvents.
Chemically stable in the presence of dilute acids, bases and salts.

NP-10 (Nonyl phenol) is compatible with soaps, anionic and other nonionic surfactants and many organic substances.
NP-10 (Nonyl phenol) can be used in cleaning product formulations where an increase in surface activity is required.
NP-10 (Nonyl phenol) has good solubilization and emulsification function.
NP-10 (Nonyl phenol) with 10 moles of ethylene oxide adducts.
NP-10 (Nonyl phenol) is used as an additive in the production of pesticides.

NP-10 (Nonyl phenol) is used as additives in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
NP-10 (Nonyl phenol) is also precursors of alkylphenol ethoxylates and nonylphenol ethoxylates, which are commercially important nonionic surfactants used in detergents, paints, pesticides, personal care products and plastics.
In the agricultural field, NP-10 (Nonyl phenol) is used together with rosin during adhesive production, as NP 10 reduces surface tension and acts as a good wetting agent.

NP-10 (Nonyl phenol) for use in paints and coatings, paper and textile processing, cleaners and detergents, agrochemicals, and metalworking fluids; with excellent detergency, outstanding wetting, versatile solubility characteristics, and exceptional handling properties.
NP-10 (Nonyl phenol) can also be used in oilfield drilling and production formulations.
NP-10 (Nonyl phenol) is used in the manufacture of antioxidants, lubricating oil additives, laundry and dishwashing detergents, emulsifiers and solubilizers.
NP-10 (Nonyl phenol) can also be used to produce tris (4-nonyl-phenyl) phosphide (TNPP), an antioxidant used to protect polymers such as rubber, vinyl polymers, polyolefins and polystyrene,

NP-10 (Nonyl phenol) is a stabilizer in plastic food packaging.
Barium and calcium salts of NP-10 (Nonyl phenol) are also used as heat stabilizers for polyvinyl chloride (PVC).
NP-10 (Nonyl phenol) is also often used as an intermediate in the manufacture of non-ionic surfactants nonylphenol exoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
NP-10 (Nonyl phenol) is only used as components of household detergents.
Auxiliary for washing and finishing of wool, cotton, viscose, rayon and synthetic fiber.

NP-10 (Nonyl phenol) is used for washing and soaking all natural and synthetic fibers.
NP-10 (Nonyl phenol) is used in open cotton cooking, as a wetting agent in the pre-cleaning of the fiber, in an enzyme desizing bath, and as a leveling agent in dyeing.
NP-10 (Nonyl phenol) is not affected by hard waters, acidic and basic environments.
NP-10 (Nonyl phenol) has high emulsifying feature.

NP-10 (Nonyl phenol) quickly removes the filth from the fibers and takes the wax and pectin from the fiber in cotton and allows it to be easily removed.
NP-10 (Nonyl phenol) is used as an additive in formulations in many sectors, mainly shampoo and soap.
NP-10 (Nonyl phenol) tends to dissolve in both the aqueous phase and oil and reduce the surface tension of liquids.
NP-10 (Nonyl phenol), which is easily soluble in hot water, does not form any ions when dissolved in water.

NP-10 (Nonyl phenol) foams less compared to anion active substances.
NP-10 (Nonyl phenol) is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.
NP-10 (Nonyl phenol) is a non-ionic surfactant .
NP-10 (Nonyl phenol) is also works as a detergent and wetting agent.
NP-10 (Nonyl phenol) is used in cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, metalworking fluids.

NP-10 (Nonyl phenol) Surfactant is a Nonylphenol Ethoxylate based surfactant.
NP-10 (Nonyl phenol) is nonionic and provides excellent detergency, rinse-ability, and low odor.
NP-10 (Nonyl phenol) is suggested for use in cleaners & degreasers, prewash spotters and metalworking fluids.
NP-10 (Nonyl phenol) is used as an additive in formulations in many sectors, especially shampoo and soap.
NP-10 (Nonyl phenol) is used as a surfactant cleaner and degreaser in many industrial areas, especially detergents.
NP-10 (Nonyl phenol) is also used as an emulsifier in some productions.



APPLICATIONS:

-Cleaners & degreasers
-Agrochemical
-Oil in water emulsion
-Metalworking fluid
-Paint & coatings



USAGE:

-In detergent production,
-antioxidants,
-in lubricating oil additives,
-in paint production,
-laundry and dishwashing detergents,
-in insecticides,
-in plastic,
-in emulsifiers and solubilizers,
-Used in the manufacture of personal care products



USES:

-Used as cleaners & detergents
-degreasers
-paper & textile processing
-paints
-prewash spotters
-agrochemicals
-metalworking fluids
-oil field chemicals.



APPLICATIONS:

NP-10 (Nonyl phenol) is used in manufacturing antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solubilizers.
NP-10 (Nonyl phenol) can also be used to produce tris(4-nonyl-phenyl) phosphite (TNPP), which is an antioxidant used to protect polymers, such as rubber, Vinyl polymers, polyolefins, and polystyrenics in addition to being a stabilizer in plastic food packaging.
Barium and calcium salts of nonylphenol are also used as heat stabilizers for polyvinyl chloride (PVC).
NP-10 (Nonyl phenol) is also often used an intermediate in the manufacture of the non-ionic surfactants nonylphenol exthoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
NP-10 (Nonyl phenol) is only used as components of household detergents outside of Europe.
NP-10 (Nonyl phenol) is used in many epoxy formulations mainly in North America.



TYPICAL PROPERTIES:

-Molecular Weight: 682
-pH-1% in 10/6 ISOP/H2O: 5.0 - 8.0
-Water: 0.3 Max
-Color: 50 Max
-Physical Appearance: Pale yellow
-Cloud Point in 1% aq.: 60 - 65
-Critical Micelle Concentration (1% aq): 61
-HLB (nominal): 13.2
-Average Moles of EO: 10
-Pour Point: 6
-Surface Tension (0.1% aq @ 25°C): 33




PHYSICAL AND CHEMICAL PROPERTIES:

-Molecular Formula: C7H9N3O4
-Molar Mass: 199.16
-Density: 1.60±0.1 g/cm3(Predicted)
-Melting Point: 175-176 °C
-Boling Point: 423.2±35.0 °C(Predicted)
-pKa: 13.44±0.10(Predicted)



STRUCTURE:

NP-10 (Nonyl phenol) falls into the general chemical category of alkylphenols.
The structure of NP-10 (Nonyl phenol) may vary.
The nonyl group can be attached to the phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear.
A branched nonylphenol, 4-nonylphenol, is the most widely produced and marketed nonylphenol.
The mixture of nonylphenol isomers is a pale yellow liquid, although the pure compounds are colorless.
NP-10 (Nonyl phenol) is moderately soluble in water but soluble in alcohol.

NP-10 (Nonyl phenol) arises from the environmental degradation of nonylphenol ethoxylates, which are the metabolites of commercial detergents called alkylphenol ethoxylates. NP-10 (Nonyl phenol) is a clear to light orange color liquid.
NP-10 (Nonyl phenol) is nonionic in water, which means that they have no charge.
Because of this property they are used as detergents, cleaners, emulsifiers, and a variety of other applications.
They are amphipathic, meaning they have both hydrophilic and hydrophobic properties, which allows them to surround non-polar substances like oil and grease, isolating them from water.



PRODUCTION:

NP-10 (Nonyl phenol) can be produced industrially, naturally, and by the environmental degradation of alkylphenol ethoxylates.
Industrially, NP-10 (Nonyl phenol) is produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes.
This synthesis leads to a very complex mixture with diverse nonylphenols.
Theoretically there are 211 constitutional isomers and this number rise to 550 isomers if we take the enantiomers into account.
To make NPEs, manufacturers treat NP-10 (Nonyl phenol) with ethylene oxide under basic conditions.

Since its discovery in 1940, NP-10 (Nonyl phenol) production has increased exponentially, and between 100 and 500 million pounds of nonylphenol are produced globally every year, meeting the definition of High Production Volume Chemicals.
NP-10 (Nonyl phenol) is also produced naturally in the environment. One organism, the velvet worm, produces nonylphenol as a component of its defensive slime.
NP-10 (Nonyl phenol) coats the ejection channel of the slime, stopping it from sticking to the organism when it is secreted.
NP-10 (Nonyl phenol) also prolongs the drying process long enough for the slime to reach its target.



FUNCTION:

-Additives for ceramics
-Additives for tight concrete
-Additives improving lubricity
-Additives to increase the strength of concrete
-Anti-stain agents
-Antifoam agents
-Antifoaming agents
-Antifogging agents
-Antifreezing agents
-Antioxidants
-Antiscalants
-Antistatics
-Antiwear Additives
-Base surfactants
-Bath salts
-Binders
-Biocides
-Disinfecting agents
-Bleaching agents
-Bleaches and whitening additives
-Coatings, adhesives, sealants, elastomers
-Chelators
-Cleaning agents
-Additives and formulations for cleaning
-Complexing agents
-Corrosion inhibitors
-Anticorrosive additives
-Cross-linking agents
-Defoamers
-Foam reducing agents
-Degreasing agents
-Grease removing agents
-Demulsifiers
-Emulsion breakers
-Descaling agents
-Preparations for limescale removal
-Detergents
-Disinfectants and biocides
-Disinfectants
-Dispersants
-Dispersing agents
-Drying agents
-Emollients
-Moisturizing agents
-Emulsifiers
-O/W and W/O emulsifying substances
-Equalizators
-Equalizing agents
-Extreme pressure additives
-EP additives for metalworking
-Filling agents
-Fillers for laundry detergents
-Film-forming additives in Li-Ion batteries
-Fire fighting
-Foam-forming extinguishing agents
-Flame retardants
-Fire retardants
-Flexible foams
-Elastic polyurethane foams (PUR)
-Flocculants
-Coagulating agents
-Fluidising agents
-Liquefying agents
-Foam stabiliser
-Foaming agents
-Foam generating substances
-Formulation stabilizers
-Fresheners
-Air and fabric refresher
-Functional fluids
-Hydraulic and heat transferring liquids
-Fungicides
-Gaseous silicon precursor
-Hair shampoos
-Hardeners
-Stabilization against dusting
-Heat stabilizers
-Substances preventing polymer degradation
-High-foaming agents
-Humectants
-Water-binding additives
-Hydrotropes
-Additives increasing solubility
-Impregnation agents
-Inreactor antistats
-Mold release agent
-Insulation
-Thermal and acoustic insulations
-Integral foams
-Integral polyurethane foams (PUR)
-Liquid silica precursors
-Liquid soaps
-Low foaming agent
-Low foaming surfactants
-Lubricants
-Industrial lubricating fluids
-Lubricants and fluids
-Industrial lubricants and greases
-Metal flotation
-Interceptors for separation of minerals
-Metal plating agents
-Electroplating bath additives
-Metal working fluids
-Substances for metalworking
-Neutral rust removers
-Rust removal agents
-One-component foams (OCF)
-Oxygen scavengers
-Preparations removing oxygen from systems
-Plastic bottles and canisters
-Pearlizing agents
-Products applying pearl effect
-pH regulators
-Substances regulating pH level
-Plasticizers



PROPERTIES:

-Chemical Formula: C15H24O
-pH: 6-7
-Melting point: 6 °C
-Boiling point: 270 °C
-Physical appearance: Liquid, clear colorless



SPECIFICATIONS:

-Cloud Point (1% aqueous solution): 63 °C
-Foam Height - Initial (0.1% active by weight): 115 mm
-Foam Height - 5 minutes (0.1% active by weight): 110 mm
-HLB: 13.2
-Pour Point: 6 °C
-Surface Tension (1% active, 25 °C): 33 dynes/cm
-Appearance: Slightly misted
-Color: Colorless to pale yellow
-pH: 5.0 - 8.0




PROPERTIES:

-CAS numarası : 26027-38-3
-Suda Çözünürlük: Çözünür (; kerosen içinde çözünmez, metanol içinde çözünür ksilen)
-Ph: 6.3 (10% çöz.)
-Vİskozite (EBM): C 25 240
-Flash noktası: 94 0C
-Moleküler formül: C9H19C6H4 (OCH2CH2) NOH
-Erime noktası: 1 0C
-Özgül ağırlık: 1.06



SYNONYM:

Nonyl Phenol On Ethoxy Silate
NONYL PHENOL 10EO
Nonylphenol 10EO
2-(p-Nonylphenoxy)ethanol
Nonoxinol
NONOXYNOL
2-(4-nonylphenoxy)ethanol
Nonoxynols
104-35-8
Nonoxynol-7
Nonoxynol 10
nonylphenol ethoxylate
Conceptrol
Egyptol
Intercept
Koromex
Semicid
Emko
Ethanol, 2-(4-nonylphenoxy)-
Encare oval
Today Sponge
Ortho-Creme
Nonoxynol 4
Nonoxynol 6
Liponox NCY
Gynol II
Advantage 24
Nonoxynol 13
Nonoxynol 14
Nonoxynol 15
Nonoxynol 30
Nonoxynol-14
Nonoxynol-18
Nonoxynol-50
Cremophor NP 10
Cremophor NP 14
Imbetin N 7A
Nonoxynol 8.5
4-Nonyl Phenol Monoethoxylate
Emulan 30
Emulan 40
K-Y Plus
NP-9
Akyporox NP 150
Newcol 565
Pannox 110
Pannox 111
Pannox 116
Amway APSA 80
Bion NE 9
Iconol NP 100
Monopol NP 1013
Monopol NP 1060
Hyoxyd X 100
Hyoxyd X 200
Hyoxyd X 400
Nonoxynol 4 [USAN]
Nonoxynol 15 [USAN]
Nonoxynol 30 [USAN]
Ethoxylated p-nonyl phenol
p-Nonylphenol, ethoxylated
PEG-7 Nonyl phenyl ether
NOP 8
PEG-14 Nonyl phenyl ether
PEG-18 Nonyl phenyl ether
PEG-50 Nonyl phenyl ether
2-(4-Nonylphenoxy) ethanol
APSA 80
4-Nonylphenol decaglycol ether
Polyethylene glycol 100 nonyl phenyl ether
Polyoxyethylated-p-nonyl phenol
NOP 17
Polyoxyethylene nonylphenyl ether
HSDB 7217
Amway All Purpose Spray Adjuvant
p-Nonylphenyl polyoxyethylene ether
Nonylphenoxypoly(ethyleneoxy)ethanol
NP 8.5
Decaethylene glycol p-nonylphenyl ether
p-Nonylphenol decaethylene glycol ether
Polyoxyethylene (7) nonyl phenyl ether
p-Nonylphenol-polyethylene glycol adduct
Polyoxyethylene (14) nonyl phenyl ether
Polyoxyethylene (18) nonyl phenyl ether
Polyoxyethylene (50) nonyl phenyl ether
Nonoxynol 4 (USAN)
Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-
Polyethylene glycol (7) nonyl phenyl ether
Nonoxynol 15 (USAN)
Nonoxynol 30 (USAN)
Decaethylene glycol mono(p-nonylphenyl) ether
N 100
Polyethylene glycol (14) nonyl phenyl ether
Polyethylene glycol (18) nonyl phenyl ether
Polyethylene glycol (50) nonyl phenyl ether
Polyethylene glycol mono(p-nonylphenyl) ether
Glycols, polyethylene, mono(p-nonylphenyl) ether
alpha-(p-Nonylphenyl)-omega-hydroxydeca(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxynona(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxypoly(oxyethylene)
Phenol, p-nonyl-, monoether with polyethylene glycol
alpha-(p-Nonylphenyl)-omega-hydroxytetra(oxyethylene)
4-n-Nonylphenol-mono-ethoxylate
alpha-(p-Nonylphenyl)-omega-hydroxypentadeca(oxyethylene)
alpha-(p-Nonylphenyl)-omega-hydroxytriaconta(oxyethylene)
Nonoxinols
C18H30O2
Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy
Emulgen 911
Emulgin 913
Nonylphenoxypolyethoxyethanols
127087-87-0
Nonoxinol [INN]
Delfen (TN)
Nonoxynol 9 (USP)
616.82 average
Nonoxynol 9 [USAN]
OSD2GAP7HY
UNII-OSD2GAP7HY
NONOXINOL 15
NONOXINOL 30
11096-42-7
PEG-2 Nonyl phenyl ether
UNII-1F75BOT2DZ
UNII-60ZT1XYO5N
UNII-HR8408HWGL
1F75BOT2DZ
60ZT1XYO5N
HR8408HWGL
Nonoxynol 9 [USAN:USP]
UNII-4867M0AEJI
UNII-ED8J5T817W
UNII-JJX07DG188
nonylphenoxy polyethoxy ethanol
SCHEMBL198140
UNII-3X709X44TE
UNII-48Q180SH9T
UNII-5V4827GL2O
UNII-6FW840C8W9
UNII-6NR43D77O6
UNII-8869L92EOT
UNII-E9AU396Z19
UNII-K7O76887AP
UNII-KND68343W4
UNII-M693M091RR
4867M0AEJI
CCRIS 8448
ED8J5T817W
JJX07DG188
CHEMBL1797943
DTXSID4058601
UNII-A906T4D368
UNII-BK168521Q8
(oxyeth-ylene) nonylphenyl ether
CHEBI:53774
CTK5H8961
KUXGUCNZFCVULO-UHFFFAOYSA-N
3X709X44TE
48Q180SH9T
5V4827GL2O
6FW840C8W9
6NR43D77O6
8869L92EOT
E9AU396Z19
K7O76887AP
KND68343W4
M693M091RR
KS-000014UE
ZINC1850508
C33H60O10
AKOS026749958
A906T4D368
BK168521Q8
Polyoxyethylene (2) nonyl phenyl ether
96827-63-3
LS-72940
FT-0673037
X7302
Polyethylene glycol mono(4-nonylphenyl) ether
D06490
alpha-(4-nonylphenyl)-omega-hydroxypoly(oxyethylene)
J-001157
4-Nonylphenol-mono-ethoxylate 10 microg/mL in Acetone
4-Nonylphenol-mono-ethoxylate 10 microg/mL in Methanol
1-(2-Hydroxyethyl)-5-nitro-1H-pyrrole-2-carboxamide
Np-10
Np-10 (Nonylphenol ethoxylate)
1-(2-hydroxyethyl)-5-nitropyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide, 1-(2-hydroxyethyl)-5-nitro-
1-(2-Hydroxyethyl)-2-carbamoyl-5-nitropyrrol
1-(2-Hydroxyethyl)-5-nitro-1H-pyrrole-2-carboxamide
1-(2-hydroxyethyl)-5-nitropyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide, 1-(2-hydroxyethyl)-5-nitro-
NP 10
NP 10 (Pharmaceutical)
Np-10 (Nonylphenol ethoxylate)
Pyrrole-2-carboxamide,1-(2-hydroxyethyl)-5-nitro


















NP-40 (ETHOXYLATED NONYLPHENOL)
NP-40 (ethoxylated nonylphenol) has a role as a nonionic surfactant.


CAS Number: 26027-38-3
EC Number: 500-024-6
Chemical formula: H(C2H4O)nO(C6H4)C9H19



Polyethylene glycol nonylphenyl ether, Nonyl phenoxypolyethoxylethanol, Nonoxynol-40, Igepal CA-630, T-DET O-series, ethoxylated octylphenol, T-DET O-9, Nonidet P40 substitute, Nonylphenol Ethoxylate, Tergitol NP-40 Surfactant, [Octylphenoxy]Polyethoxyethanol, branched, [Octylphenoxy]Polyethoxyethanol,
Polyoxyethylene (9) isooctylphenyl ether, Igepal CA-630, Anapoe-NID-P40, NP40 Alternative, Lissapol, TX100 CAS : 9002-93-1, n-9, IKD, np-9, N 100, NOP 8, NOP 17, Encare, Koromex, Egyptol, NP 1060, PONPE 10, PONPE 15, PONPE 20, FLJ20643, K-Y Plus, Gynol II, Emulan 30, Emulan 40, Novoxynol, Conceptol, PONPE 7.5, Intercept, Pannox 16, Pannox 18, Nonal 106, Nonal 202, Nonal 204, nonoxynol, Tergitol7, NONOXINOLS, Pannox 110, Pannox 111, Pannox 116, Pannox 140, Pannox 150, Newcol 565, Encare oval, Liponox NCY, NONOXYNOL-8, NONOXYNOL-3, NONOXYNOL-1, nonoxynol-2, nonoxynol-4, nonoxynol-6, nonoxynol-7, SURFONIC 95, NONOXYNOL-9, nonoxynol-40, nonoxynol-20, nonoxynol-10, nonoxynol-12, nonoxynol-13, nonoxynol-15, NONOXYNOL-14, NONOXYNOL-18, NONOXYNOL-23, NONOXYNOL-30, NONOXYNOL-35, NONOXYNOL-44, NONOXYNOL-50, Imbetin N 7A, Hyoxyd X 100, Hyoxyd X 200, Hyoxyd X 400, Iconol NP 100, Findet 9Q21.5, Neutronyx 611, Emulsogen ELN, Nonoxynol 8.5, NONOXYNOL-100, NONOXYNOL-120, igepal co-720, igepal co-890, igepal co-990, Igepal?CO-720, Igepal?CO-890, Igepal?CO-990, VANWET 9N9(R), IGEPAL CO-210, TERGITOL NO 7, TERGITOL NP-10, TERGITOL NP 35, TERGITOL NP 44, Nonoxynol, n=9, Monopol NP 1013, Monopol NP 1060, NONIDET(TM) P40, TERGITOL(R) NP-10, Nonyl phenol ether 9, Nonoxynol 9 (0.5 mL), Nonoxynol 10 (200 mg), PEG p-nonylphenyl ether, TERGITOLNP-6,SURFACTANT, TERGITOLNP-7,SURFACTANT, TERGITOLNP-8,SURFACTANT, TERGITOLNP-9,SURFACTANT, TERGITOLNP-10,SURFACTANT, TERGITOLNP-40,SURFACTANT, 4-NONYLPHENOL-ETHOXYLATE, NONYLPHENOLTRIETHOXYLATE, SODIUM HEPTADECYL SULFATE, p-nonylphenolglycolether, Ethoxylated p-nonyl phenol, Tergitol(R) NP-6, Surfactant, Tergitol(R) NP-8, Surfactant, 4-Nonylphenol polyethoxylate, Tergitol(R) NP-10, Surfactant, ethyleneoxideadductnonylphenol, Polyoxyethylated-p-nonylphenol, Polyoxyethylenenonylphenylether,
NONYLPHENYL-POLYETHYLENE GLYCOL, Polyoxyethylene-n-nonylphenyl ether, 4-nonylphenol-ethoxylate (technical), nonylphenoxyhydroxypoly(oxyethylene),
POLYOXYETHYLENE(10) NONYLPHENYL ETHER, EO-4)(ETHOXYLATED P-NONYLPHENOL (EO-4), Polyethylen Glycol Monononylphenol Ether, DIETHYLENE GLYCOL MONO(P-NONYLPHENYL) ETHER, POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER, POLYETHYLENE GLYCOL MONO-P-NONYLPHENYL ETHER, p-nonyl-henomonoetherwithpolyethyleneglycol, Polyethylene Glycol Mono-4-nonylphenyl Ester, glycols,polyethylene,mono(p-nonylphenyl)ether, Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)2, Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)5, Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)10, Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)15, Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)18, olyethylene Glycol Mono-4-nonylphenyl Ether n(=:)20, Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)7.5, OMEGA-HYDROXYPOLY-(OXYETHYLENE)-ALPHA-(4-NONYLPHENOL), Poly(oxy-1,2-ethanediyl),a-(4-nonylphenyl)-w-hydroxy-, Poly(oxy-1,2-ethanediyl), α-(4-nonylphenyl)-ω-hydroxy-, ALPHA-(PARA-NONYLPHENOL)-OMEGA-HYDROXYPOLY(OXYETHYLENE), alpha-(4-nonylphenyl)-omega-hydroxy-poly(oxy-2-ethanediyl), Polyethylene Glycol Mono-4-nonylphenyl Ether (n=approx. 2), Polyethylene Glycol Mono-4-nonylphenyl Ether (n=approx. 5), Polyethylene Glycol Mono-4-nonylphenyl Ether (n=approx. 20), Polyethylene Glycol Mono-4-nonylphenyl Ether (n=approx. 10), Polyethylene Glycol Mono-4-nonylphenyl Ether (n=approx. 15),
Polyethylene Glycol Mono-4-nonylphenyl Ether (n=approx. 18), .alpha.-(p-Nonylphenyl)-.omega.-hydroxypoly(n=100)(oxyethylene), Glycols, polyethylene, mono(p-nonylphenyl) ether: (Nonoxynol-9), 2-ethanediyl),.alpha.-(4-nonylphenyl)-.omega.-hydroxy-Poly(oxy-1, Poly(oxy-1,2-ethanediyl),.alpha.-(4-nonylphenyl)-.omega.-hydroxy-, Alkylphenol ethoxylates: Nonylphenol-ethylene oxide condensate (Nonoxynol-9),



NP-40 (ethoxylated nonylphenol) is a clear, colourless or light yellow, viscous liquid.
NP-40 (ethoxylated nonylphenol) is a poly(ethylene glycol) derivative that is poly(ethylene glycol) in which one of the terminal hydroxy groups has been converted into the corresponding p-nonylphenyl ether.


NP-40 (ethoxylated nonylphenol) has a role as a nonionic surfactant.
NP-40 (ethoxylated nonylphenol) is a poly(ethylene glycol) derivative and a hydroxypolyether.
NP-40 (ethoxylated nonylphenol) is registered under the REACH Regulation but is not currently being manufactured in and / or imported to the European Economic Area.


NP-40 (ethoxylated nonylphenol) is an anhydrous liquid nonionic surface- active agent produced by the reaction of octyl phenol with 8.5-9.5 moles of ethylene oxide.
NP-40 (ethoxylated nonylphenol) is a nonionic surfactant used in the isolation of membrane complexes.


NP-40 (ethoxylated nonylphenol) has been reformulated to be eco-friendly.
The only observable differences are that the viscosity and handling characteristics are somewhat modified.
Due to its nonionic structure, NP-40 (ethoxylated nonylphenol) is compatible with anionic surfactants and is stable in the presence of acids, bases, and salts.


NP-40 (ethoxylated nonylphenol) should not be mixed with concentrated oxidizing or reducing agents since the mixture of these compounds with organic compounds could form a potentially explosive mixture.
NP-40 (ethoxylated nonylphenol) is an effective emulsifier for solvents such as xylene.



USES and APPLICATIONS of NP-40 (ETHOXYLATED NONYLPHENOL):
NP-40 (ethoxylated nonylphenol) is used in formulation or re-packing.
NP-40 (ethoxylated nonylphenol) is used in the following products: washing & cleaning products.
Release to the environment of NP-40 (ethoxylated nonylphenol) can occur from industrial use: formulation of mixtures.


NP-40 (ethoxylated nonylphenol), a surfactant compound extensively utilized in diverse industrial and biomedical applications, is synthesized through a chemical process involving the reaction of nonylphenol with ethylene oxide.
The potential applications of NP-40 (ethoxylated nonylphenol) as a spermicide and microbicide have been the subject of extensive research.


NP-40 (ethoxylated nonylphenol)'s efficacy in combating a broad spectrum of microorganisms, including bacteria, fungi, and viruses, has been demonstrated.
Moreover, NP-40 (ethoxylated nonylphenol) finds utility as a detergent and emulsifying agent across various industrial sectors.
The mechanism of action employed by NP-40 (ethoxylated nonylphenol) involves the disruption of the cell membrane of microorganisms.


By inserting itself into the lipid bilayer of the cell membrane, NP-40 (ethoxylated nonylphenol) induces destabilization.
Consequently, the intracellular contents are released, leading to the eventual demise of the microorganism.
NP-40 (ethoxylated nonylphenol) is used at industrial sites.


NP-40 (ethoxylated nonylphenol) is used in the following products: metal surface treatment products.
Release to the environment of NP-40 (ethoxylated nonylphenol) can occur from industrial use: in processing aids at industrial sites and as processing aid.
NP-40 (ethoxylated nonylphenol) is used as emulsifier, washing agent, wetting agent, penetrating agent, dispersing agent, degreasing agent, refining agent and chemical intermediate in the industry .


NP-40 (ethoxylated nonylphenol) is used as cleaners & detergents, paper & textile processing, paints & coatings, agrochemicals, emulsifier, wetting agents and stabilizers. Possesses detergency.
NP-40 (ethoxylated nonylphenol) is used as a compounding agent with a higher water content than oil.


They are used in the manufacture of antioxidants, lubricating oil additives, laundry and dish detergents, emulsifiers, and solvents.
NP-40 (ethoxylated nonylphenol) functions as a wetting agent and cleaning mixture in making detergent.
Nonylphenols are a family of closely related organic compounds consisting of phenols containing 9 carbon tails.


Nonylphenols can come in a variety of structures, all of which can be considered alkylphenols.
Function of NP-40 (ethoxylated nonylphenol): as a wetting agent and cleaning mixture in making detergent.
NP-40 (ethoxylated nonylphenol) is used as nonionic surface-active agent.


Furthermore in Biochemistry, NP-40 (ethoxylated nonylphenol) is a nonionic surfactant used in the isolation of membrane complexes.
Due to its nonionic structure, NP-40 (ethoxylated nonylphenol) is compatible with anionic surfactants and is stable in the presence of acids, bases, and salts.


NP-40 (ethoxylated nonylphenol) should not be mixed with concentrated oxidizing or reducing agents since the mixture of these compounds with organic compounds could form a potentially explosive mixture.
NP-40 (ethoxylated nonylphenol) is used spermatocide, contraceptive.


NP-40 (ethoxylated nonylphenol) and nonyl phenoxypolyethoxylethanol) is a commercially available detergent with CAS Registry Number 9016-45-9.
NP-40 (ethoxylated nonylphenol) is an ethoxylated nonylphenol for non-ionic surfactants and can act as emulsifier and demulsifier agent.
NP-40 (ethoxylated nonylphenol) is often used to break open all membranes within a cell, including the nuclear membrane.


Nonionic surfactant for use in paper and textile processing, paints & coatings, and agrochemicals; featuring versatile solubility characteristics, high water solubility, suitability for use at higher temperatures​​​​​​​.
NP-40 (ethoxylated nonylphenol) is an effective emulsifier for solvents such as xylene.


Uses of NP-40 (ethoxylated nonylphenol): Cleaning product formulations, Paints and coatings, Emulsion polymerization, Anywhere there is a need for increased surface activity.
To break only the cytoplasmic membrane, other detergents such as digitonin can be used.
NP-40 (ethoxylated nonylphenol) has applications in paper and textile processing, in paints and coatings, and in agrochemical manufacturing.


-NP-40 (ethoxylated nonylphenol) is suitable for use in applications such as:
• Cleaners & detergents
• Paper & textile processing
• Laundry
• Paints & coatings
• Dust control
• Agrochemicals
• Metalworking fluids



BENEFITS OF NP-40 (ETHOXYLATED NONYLPHENOL):
*Deliver a combination of economy and performance
*Excellent detergency and wetting
*Good solubilization and emulsification
*Excellent detergency
*Outstanding wetting
*Versatile solubility characteristics
*Exceptional handling properties
*Low odor
*Good rinseability



PHYSICAL and CHEMICAL PROPERTIES of NP-40 (ETHOXYLATED NONYLPHENOL):
Chemical formula: H(C2H4O)nO(C6H4)C9H19
Molar mass: Variable
General Specifications:Appearance:
Colorless to pale yellow, clear, viscous liquid
pH (1% aqueous):5-7
Water:≤0.50%
Specific Gravity (25°C):1.065
Viscosity (cP, 25°C):~246
Surface Tension (0.1% aqueous, 25°C):~30 dynes/cm
Flash Point (PMCC):260°C
Pour Point:7°C
Cloud Point (1% aq):64-68°C
Surface Tension (1% aq):35 dynes/cm
Odor:Mild Aromatic
Boiling point: 30℃
Density: 1.00
vapor pressure: 0 Pa at 25℃
refractive index: 1.4950-1.4990

Flash point: >150℃
storage temp.: Sealed in dry,Room Temperature
solubility: Miscible with water, with ethanol (96 per cent) and with vegetable oils.
form: powder to lump to clear liquid
color: Almost colorless liquid
Water Solubility: 1 g/L
Merck: 14,6677
InChIKey: HNLXNOZHXNSSPN-UHFFFAOYSA-N
LogP: 4.48
Indirect Additives used in Food Contact Substances: NONOXYNOL
FDA 21 CFR: 175.105
EWG's Food Scores: 2-4
FDA UNII: NONOXYNOL-6 (1F75BOT2DZ)
NONOXYNOL-15 (5V4827GL2O)
NONOXYNOL-18 (3X709X44TE)
NONOXYNOL-40 (4867M0AEJI)
NONOXYNOL-9 (48Q180SH9T)

EPA Substance Registry System: p-Nonylphenol polyethylene glycol ether (26027-38-3)
Cosmetics Info: Nonoxynol-4
Chemical stability: The product is chemically stable under standard ambient conditions (room temperature) .
Physical state: liquid
Color: light yellow
Odor: No data available
Melting point/freezing point: 5 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: > 150 °C
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 6,0

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,05 g/cm3 at 25 °C
Relative density No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available



FIRST AID MEASURES of NP-40 (ETHOXYLATED NONYLPHENOL):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NP-40 (ETHOXYLATED NONYLPHENOL):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NP-40 (ETHOXYLATED NONYLPHENOL):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NP-40 (ETHOXYLATED NONYLPHENOL):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection:
Tightly fitting safety goggles
*Skin protection:
required
*Body Protection:
protective clothing
-Respiratory protection:
Recommended Filter type: Filter type ABEK
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NP-40 (ETHOXYLATED NONYLPHENOL):
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of NP-40 (ETHOXYLATED NONYLPHENOL):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions
No data available:
-Incompatible materials:
No data available


N-Phosphonomethyl Iminodiacetic Acid
N-(Carboxymethyl)-N-(phosphonomethyl)glycine; Phosphonomethyliminodiacetic acid; N-(phosphonomethyl)iminodiacetic acid; 2,2'-((Phosphonomethyl)azanediyl)diacetic acid; 2,2'-[(phosphonomethyl)imino]diacetic acid; Glycine, N-(carboxymethyl)-N-(phosphonomethyl)-; N-(Carboxymethyl)-N-(phosphonomethyl)-glycine cas no: 5994-61-6
n-PROPANOL
n-propanol is an important organic substance that is used in industry.
n-propanol is a colorless liquid with alcohol odor.
n-propanol is a byproduct obtained by hydroformylation of allyl alcohol with carbon monoxide and hydrogen, which is then followed by hydrogenation.


CAS Number: 71-23-8
EC Number: 200-746-9
MDL Number: MFCD00002941
Molecular Formula: C3H8O / CH3CH2CH2OH


n-propanol is a primary alcohol with the formula CH3CH2CH2OH.
This colorless liquid, n-propanol, is also known as propan-1-ol, 1-propyl alcohol, n-propyl alcohol, n-propanol, or simply propanol.
n-propanol is pure, clear liquid with a mild odour and medium volatility.


n-propanol is water soluble.
n-propanol acts as a clear, polar, non-HAP solvent.
n-propanol improves drying characteristics in coating applications.


n-propanol possesses a very mild odor.
n-propanol exhibits free miscibility with water and with all common solvents such as glycols, ketones, alcohols, aldehydes, ethers, aromatic & aliphatic hydrocarbons.


n-propanol, also known as propanol or ethylcarbinol, is a member of the class of compounds known as primary alcohols.
Primary alcohols are compounds comprising the primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl).
Thus, n-propanol is considered to be a fatty alcohol lipid molecule.


n-propanol is soluble (in water) and an extremely weak acidic compound (based on its pKa).
n-propanol can be found in a number of food items such as cashew nut, chinese mustard, greenthread tea, and chayote, which makes n-propanol a potential biomarker for the consumption of these food products.


n-propanol can be found primarily in blood, feces, and saliva, as well as in human fibroblasts tissue.
n-propanol exists in all eukaryotes, ranging from yeast to humans.
In humans, n-propanol is involved in the sulfate/sulfite metabolism.


n-propanol is also involved in sulfite oxidase deficiency, which is a metabolic disorder.
n-propanol or propan-1-ol : CH3CH2CH2OH, the most common meaning 2-Propanol, Isopropyl alcohol, isopropanol, or propan-2-ol : (CH3)2CHOH .
n-propanol belongs to the class of organic compounds known as primary alcohols.


Primary alcohols are compounds comprising the primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl).
n-propanol is three-carbon saturated aliphatic alcohol.
n-propanol is called 1-propanol.


Another name for n-propanol is propyl alcohol.
n-propanol has a structure very similar to ethyl alcohol in terms of n-propanol chemistry and properties.
n-propanol is colorless, and fluid.


n-propanol is used in the industry as an important organic substance, solvent and antifreeze.
n-propanol is a clear, colorless liquid at room temperature with an odor like that of rubbing alcohol (Isopropyl Alcohol).
n-propanol is miscible with water and is highly flammable.


n-propanol is used as a general solvent, fuel additive, degreasing agent, and component in antifreeze.
n-propanol is naturally formed in small amounts during fermentation processes.
n-propanol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


n-propanol, also known as 1-propanol, is an organic compound with the molecular formula C3H8O and molecular weight 60.10.
n-propanol is a colorless and transparent liquid with the odor of ethanol and is soluble in water, ethanol and ether.
n-propanol is obtained from ethylene by carbonyl synthesis of propionaldehyde, and then by reduction.


n-propanol is colorless liquid with a sweet, pleasant, mild alcoholic odor.
n-propanol is one of the most common types of alcohol.
n-propanol has the formula CH3CH2CH2OH.


Propan-1-ol, n-propyl alcohol, 1-propyl alcohol, or n-propanol are all names for this colourless oil.
Alcohols are those organic compounds which are characterised by the presence of one, two or more hydroxyl groups (−OH) that are attached to the carbon atom in an alkyl group or hydrocarbon chain.


n-propanol or propyl alcohol is the two isomeric forms of alcohol such as n-propyl alcohol or 1-propanol and isopropanol or isopropyl alcohol or 2-propanol.
The general molecular formula of n-propanol is written as C3H8O or C3H7OH.
Therefore, n-propanol molecule contains a carbon chain and a hydroxyl group in its structure.


n-propanol is an industrially important chemical compound which uses widely as a solvent in the chemical and pharmaceutical industries.
n-propanol is a byproduct obtained by hydroformylation of allyl alcohol with carbon monoxide and hydrogen, which is then followed by hydrogenation.
n-propanol is a colorless liquid with alcohol odor.


n-propanol is moderate volatilite and is soluble in water, alcohols, and ether.
n-propanol is a less toxic alcohol than methanol and ethanol with a high octane number.
Therefore, n-propanol is used as fuel in engines.


But the use of n-propanol in fuel engines is not enough popular due to its production cost and low energy density.
n-propanol, primary alcohol, 2-butanol, secondary alcohol, 2-methyl-2-propanol, tertiary alcohol, and phenol are the four known alcohols.
n-propanol is a primary alcohol and is a colourless liquid.


n-propanol has a distinctive alcohol odour and is of average volatility.
n-propanol is miscible with most organic solvents.
n-propanol is a colorless, weakly alcoholic (narcotic) smelling liquid.


n-propanol is miscible with water, alcohol and ether in any ratio.
n-propanol, a three-carbon straight chain oxo alcohol, is a medium boiling, colorless liquid that is widely used in flexographic and other printing ink applications.


n-propanol has a very mild odor, similar to that of ethanol and is completely soluble in water.
n-propanol is useful in organic synthesis, as a chemical intermediate, and as a coating solvent.
n-propanol helps balance the drying and flow characteristics in a variety of surface coating applications.


n-propanol (also propanol, n-propyl alcohol) is a primary alcohol with the formula CH3CH2CH2OH and sometimes represented as PrOH or n-PrOH.
n-propanol is a colourless liquid and an isomer of 2-propanol.
n-propanol appears as a clear colorless liquid with a sharp musty odor like rubbing alcohol.


The flash point of n-propanol is 53-77 °F.
Autoignites of n-propanol is at 700 °F.
n-propanol's vapors are heavier than air and mildly irritate the eyes, nose, and throat.


Density of n-propanol approximately 6.5 lb / gal.
n-propanol is the parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.
n-propanol has a role as a protic solvent and a metabolite.


n-propanol is a short-chain primary fatty alcohol and a member of propan-1-ols.
n-propanol is a colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
n-propanol is a natural product found in Aloe africana, Cichorium endivia, and other organisms with data available.


n-propanol is a metabolite found in or produced by Saccharomyces cerevisiae.
n-propanol (also known as 1-propanol, n-propanol alcohol, propan-1-ol, propyl alcohol) is a primary alcohol in which the OH entity is bonded to a primary carbon atom.


n-propanol (CH3CH2CH2OH) is one of two isomers of propanol (C3H8O); the other is 2-propanol ((CH3)2CHOH).
n-propanol is a clear, colourless transparent liquid that has a typical sharp musty odour that is comparable with the smell of rubbing alcohol.
n-propanol sits in the alcohol and polyol reactive groups.


n-propanol reacts with alkali metal, nitrides, oxoacids and carboxylic acids.
n-propanol is not reactive with strong oxidising agents.
n-propanol reacts the same way as primary alcohols.
n-propanol can be converted to alkyl halides (red phosphorus, iodine), acetic acid to give propyl acetate and chromic acids to give propionic acid.



USES and APPLICATIONS of n-PROPANOL:
n-propanol is a useful solvent that dissolves a wide range of non-polar chemical compounds.
n-propanol is also used for the production of various solvents such as antifreeze, lacquer, soap solutions, dye solutions, etc.
In medicine and healthcare, n-propanol is used for the production of disinfectants, rubbing alcohol, and hand sanitizers.


n-propanol is a very good solvent for resins and cellulose esters.
In some cases, n-propanol is used in medicine and disinfectant production.
n-propanol is also commonly used in acetone production.


n-propanol is also a very good fuel for preventing knocking in engines.
n-propanol is suitable for use due to its high octane and it is rarely used as fuel as it has high cost.
n-propanol is used industrially in organic synthesis, production of primary esters (n-propyl acetate), paints and varnishes, thinners, printing inks for flexible packaging.


n-propanol is also used in medicine as an anesthetic but due to toxicity, it is not safe for use for such purposes.
n-propanol is used for the production of is used as a chemical intermediate.
In biological laboratories, n-propanol is used for the preservation of biological specimens.


In chemical laboratories, n-propanol or isopropanol is used widely to dissolve many chemical compounds.
Cosmetic Uses of n-propanol: antifoaming agents, and solvents
Applications of n-propanol: Agriculture intermediates, Architectural coatings, Auto OEM, Auto plastics, Auto refinish, Commerical printing inks, Consumer printing inks, Flexographic printing inks, General industrial coatings, Graphic arts, Gravure printing inks, Marine, Packaging components non food contact,

Packaging inks non food contact, Paints & coatings, Pharmaceutical chemicals, Process solvents, Protective coatings, and Wood coatings.
n-propanol is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


n-propanol is approved for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, food and animals feeds.
n-propanol is used in the following products: lubricants and greases, anti-freeze products, coating products, finger paints, washing & cleaning products, adhesives and sealants, polishes and waxes and perfumes and fragrances.


Other release to the environment of n-propanol is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Other release to the environment of n-propanol is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).


n-propanol can be found in products with material based on: wood (e.g. floors, furniture, toys).
n-propanol is used in the following products: coating products, laboratory chemicals, washing & cleaning products, lubricants and greases, metal working fluids and plant protection products.


n-propanol is used in the following areas: scientific research and development and health services.
n-propanol is used for the manufacture of: fabricated metal products, electrical, electronic and optical equipment, machinery and vehicles and textile, leather or fur.


Other release to the environment of n-propanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


n-propanol is used in the following products: coating products and inks and toners.
Release to the environment of n-propanol can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials and in processing aids at industrial sites.


n-propanol is used in the following products: laboratory chemicals, coating products, pharmaceuticals, washing & cleaning products, lubricants and greases and metal working fluids.
n-propanol has an industrial use resulting in manufacture of another substance (use of intermediates).


n-propanol is used in the following areas: health services and formulation of mixtures and/or re-packaging.
n-propanol is used for the manufacture of: chemicals.
Release to the environment of n-propanol can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release and manufacturing of the substance.


Release to the environment of n-propanol can occur from industrial use: manufacturing of the substance, formulation of mixtures and in processing aids at industrial sites.
Coatinguses of n-propanol: Synthesis of propyl acetate, printing inks, and paint solvents.


Medicine uses of n-propanol: Probenecid, sodium valproate, erythromycin, valpromide, Butyl 2-cyanoacrylate (BCA), thiamine propyl disulfide.
n-propanol is an isomer of isopropanol (2-propanol, isopropyl alcohol).
n-propanol is formed naturally in small amounts during many fermentation processes and used as a solvent in the pharmaceutical industry mainly for resins and cellulose esters.


n-propanol has high octane numbers and it is suitable for engine fuel usage.
However, the production of propanol has been too expensive to make n-propanol a common fuel.
The research octane number (RON) of n-propanol is 118 and anti-knock index (AKI) is 108.


n-propanol is a mobile, polar solvent which is soluble in water and common organic solvents such as alcohols, ketones, aldehydes, ethers, glycols, aromatic and aliphatic hydrocarbons.
n-propanol is used as a starting material for a variety of chemical syntheses.


n-propanol is used as a building block for the production of esters, propyl amines and halides.
Due to its relatively low odour and inertness compared to other alcohols, n-propanol is frequently used in food packaging and other food contact applications.
n-propanol is widely used in the coatings industry due to its ability to improve the drying characteristics of resins and finishes.


n-propanol is used in a great many other applications due to its excellent solvent properties, such as printing ink, dispersing agents, pesticides and adhesives.
n-propanol is used as an additive in cleaners, floor polishes and degreasing fluids and as a component of de-icing agents.


n-propanol is used in coatings, flexographic and other printing inks.
n-propanol is used to obtain acetone.
n-propanol is mostly used as solvent and chemical intermediate.


n-propanol is found as an ingredient in many personal care products where it acts as a solvent and disinfectant.
n-propanol is used for Industrial and domestic cleaner, DNA Extraction, General solvent, Chemical manufacture as a reagent, Industries, Chemical, Cleaning, Paint And Ink, Automotive, Personal Care & Cosmetic, and Medical.


n-propanol is mainly used as a solvent, also can replace the lower boiling point of ethanol as a solvent, but also used in color layer analysis.
n-propanol is used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, rubbing alcohols, soaps, window cleaners, acetone and other chemicals and products.


Pharmaceuticals, floor polishes, dental lotions, lacquers, printing inks, natural gums, pigments, intermediates, dye solutions, antifreeze, gasoline additives, paint additives, and degreasing fluids all use n-propanol as a solvent.
n-propanol is easily metabolized and has no carcinogenic or mutagenic properties.


n-propanol is used as a solvent to manufacture personal care products.
n-propanol is used to manufacture herbicides and insecticides.
n-propanol is used as a solvent in flexographic and printing inks.


n-propanol is used to manufacture coatings and adhesives.
n-propanol is added to cleaners and floor polishes.
n-propanol is used in the pharmaceuticals industry.


n-propanol is used as ink solvent for inks used for food packaging.
n-propanol is used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, rubbing alcohols, soaps, window cleaners, acetone and other chemicals and products.


Propanol is used as a solvent or to make other solvents including antifreezes, lacquer formulas, soaps, dye solutions, and window cleaners.
In the printing industry and in printing ink, propanol compounds such as isopropanol or isopropyl alcohol are most widely used.
In pharmaceutics, hospitals, clean rooms, and electronics or medical device manufacturing, propanol is the most popular and widely used disinfectant.


Tremors, angina (chest pain), hypertension (high blood pressure), heart rhythm problems, and other heart or circulatory issues are treated with propranolol.
n-propanol’s also used to treat or avoid heart attacks, as well as to lessen the severity and frequency of migraines.
n-propanol, also known as n-propyl alcohol or 1-propanol, is one of two isomeric alcohols used in chemical processing as solvents and intermediates.


n-propanol is most commonly used as a solvent in cosmetics and pharmaceuticals, as well as in lacquer preparation.
n-propanol produces a variety of esters and ethers, some of which are commercially valuable.
n-propanol is used as a solvent and an intermediate.


The end user markets of n-propanol are the cosmetics, washing, motor, printing, coatings and chemical industries.
n-propanol is used in the cellulose, film, wax and paint industries as a solvent.
n-propanol is also used as fuel in engines due to its high-octane count.


However, due to its expensive nature and low energy gains, n-propanol is not commonly used.
n-propanol is used as a solvent in antifoaming in cosmetics, perfumes, flavours, fragrances, air care products, cleaning and furnishing products, paints, coatings, inks, personal care products, soaps and window cleaner.


n-propanol is formed naturally in small amounts during many fermentation processes and used as a solvent in the pharmaceutical industry, mainly for resins and cellulose esters, and, sometimes, as a disinfecting agent.


-Industry Uses of n-propanol:
n-propanol is used as a solvent in the manufacturing of pharmaceuticals, polishes, dental lotions, coatings, lacquers, printing inks, natural gums, pigments, intermediates, dye solutions, antifreeze, fuel additives, paint additives and de-greasing fluids.
n-propanol is also used as a chemical intermediate to create esters, halides, propyl amines and propyl acetate.
The end-user markets of n-propanol are the cosmetics, cleaning, motor, printing, coatings and chemical industries.


-n-propanol as fuel:
n-propanol has high octane number and is suitable for engine fuel usage.
However, n-propanol is too expensive to use as a motor fuel.
The research octane number (RON) of n-propanol is 118, and anti-knock index (AKI) is 108.



STRUCTURE OF n-PROPANOL:
n-propanol is one of the most common types of alcohol.
n-propanol has the formula CH3CH2CH2OH.
Propan-1-ol, n-propyl alcohol, 1-propyl alcohol, or n-propanol are all names of this colourless oil.



PREPARATION OF n-PROPANOL:
*From Propionaldehyde:
Propionaldehyde is catalytically hydrogenated to produce n-propanol. Propionaldehyde is made by hydroformylation ethylene with carbon monoxide and hydrogen in the presence of a catalyst like cobalt octacarbonyl or a rhodium complex in the oxo phase.
H2C=CH2 + CO + H2 → CH3CH2CH=O
CH3CH2CH=O + H2 → CH3CH2CH2OH

The synthesis of methanol (methyl alcohol) from carbon monoxide and hydrogen produces propyl alcohol as a by-product.
n-propanol can also be found in fusel oil.
n-propanol is most commonly used as a solvent in cosmetics and pharmaceuticals, as well as in lacquer preparation.
n-propanol is a colourless, flammable, and aromatic liquid that is miscible in all proportions with water and is moderately toxic.



GENERAL PROPERTIES OF n-PROPANOL:
n-propanol is a three-carboned, saturated, aliphatic alcohol.
n-propanol's features are very similar to ethyl alcohol.
n-propanol is a colorless, fluid and toxic liquid.
n-propanol is used as solvent in many different industries such as medicine and dye.
Chemically, n-propanol demonstrates characteristic reactions of primary alcohols and it is naturally formed in small amounts through fermentation.



PRODUCTION OF n-PROPANOL:
n-propanol is usually produced by hydrogenation of propionalehyde.
Oxo method is used in n-propanol's production.



ALTERNATIVE PARENTS OF n-PROPANOL:
*Hydrocarbon derivatives



SUBSTITUENTS OF n-PROPANOL:
*Hydrocarbon derivative
*Primary alcohol
*Aliphatic acyclic compound



STRUCTURE OF n-PROPANOL:
n-propanol molecule contains a carbon chain with three carbon atoms and a hydroxyl group.
The position of the hydroxyl group in n-propanol and isopropanol is different.
The chemical formula of n-propanol is written as CH3CH2CH2OH.
In an n-propanol molecule, the hydroxyl group is joined to the primary carbon atom to form the following structure.



CHEMICAL STRUCTURE OF n-PROPANOL:
n-propanol is miscible in water and freely miscible with all common solvents such as glycols, ketones, alcohols, aldehydes, ethers and aliphatic hydrocarbons, n-propanol is primarily used as a solvent in the manufacturing of pharmaceuticals, cosmetics, coatings and as a chemical intermediate.



CHEMICAL PROPERTIES OF n-PROPANOL:
n-propanol shows the normal reactions of a primary alcohol.
Thus it can be converted to alkyl halides; for example red phosphorus and iodine produce n-propyl iodide in 80% yield, while PCl3 with catalytic ZnCl2 gives n-propyl chloride.

Reaction with acetic acid in the presence of an H2SO4 catalyst under Fischer esterification conditions gives propyl acetate, while refluxing n-propanol overnight with formic acid alone can produce propyl formate in 65% yield.
Oxidation of n-propanol with Na2Cr2O7 and H2SO4 gives a 36% yield of propionaldehyde, and therefore for this type of reaction higher yielding methods using PCC or the Swern oxidation are recommended. Oxidation with chromic acid yields propionic acid.



KEY ATTRIBUTES OF n-PROPANOL:
*Complete water miscibility
*Excellent reactivity as an intermediate
*Inert - Food use with limitations
*Inert - Nonfood use
*Inherently biodegradable
*Medium evaporation rate
*Mild odor
*Non-HAP
*Non-SARA
*REACH compliant



PREPARATION OF n-PROPANOL:
n-propanol is manufactured by catalytic hydrogenation of propionaldehyde.
Propionaldehyde is produced via the oxo process by hydroformylation of ethylene using carbon monoxide and hydrogen in the presence of a catalyst such as cobalt octacarbonyl or a rhodium complex.

H2C=CH2 + CO + H2 → CH3CH2CH=O
CH3CH2CH=O + H2 → CH3CH2CH2OH
A traditional laboratory preparation of n-propanol involves treating n-propyl iodide with moist Ag2O.



STORAGE ANDD DISTRIBUTION OF n-PROPANOL:
n-propanol alcohol is typically bulk stored within a petrochemical storage facility for regulation.
Storage of n-propanol is normally in a cool, dry and well ventilated facility away from oxidising agents.
n-propanol should be kept out of direct sunlight, heat, and open flames.
n-propanol can be stored in drummed containers such as iso tanks made of stainless steel, aluminium or carbon steel.



HOW IS n-PROPANOL PRODUCED?
Normal n-propanol is manufactured by a catalytic hydrogenation of propionaldehyde.
The propionaldehyde is itself produced via the oxo process, by hydroformylation of ethylene using carbon monoxide and hydrogen in the presence of a catalyst such as cobalt octacarbonyl or a rhodium complex.

Hydrogenation is the process of adding pairs of hydrogen atoms to unsaturated compounds, with the aim of saturating these compounds.
H2C=CH2 + CO + H2 → CH3CH2CH=O
CH3CH2CH=O + H2 → CH3CH2CH2OH



BRIEF HISTORY OF n-PROPANOL:
Chancel discovered n-propanol in 1853.
He obtained it by fractional distillation of fusel oil.
This process is no longer used to prepare n-propanol



PRODUCTION PROCESS OF n-PROPANOL:
n-propanol is prepared by catalytic hydrogenation of propionaldehyde.
The propionaldehyde is produced through the oxo process, by hydroformylation of ethylene using carbon monoxide and hydrogen in the presence of a catalyst such as cobalt octacarbonyl or a rhodium complex.

H2C=CH2 + CO + H2 → CH3CH2CH=O
CH3CH2CH=O + H2 → CH3CH2CH2OH
n-propanol in labs is produced by treating n-propyl iodide with moist silver oxide (Ag2O).



DIFFERENCE BETWEEN n-PROPANOL AND ISOPROPYL ALCOHOL:
n-propanol, also known as n-propyl alcohol or 1-propanol, is one of two isomeric alcohols used in chemical processing as solvents and intermediates. Isopropyl alcohol is the second isomer (2-propanol).
Position isomerism can be seen in n-propanol and isopropyl alcohol.

Constitutional isomers have the same carbon skeleton and functional groups, but the functional groups are in different places.
The OH group is present on the first C atom in n-propanol.
The OH group is present on the second C atom in isopropyl alcohol.
When heated with I2 and NaOH solution, isopropyl alcohol produces a yellow iodoform precipitate, while n-propyl does not.



PHYSICAL and CHEMICAL PROPERTIES of n-PROPANOL:
Molecular Weight: 60.10 g/mol
XLogP3: 0.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 1
Exact Mass: 60.057514874 g/mol
Monoisotopic Mass: 60.057514874 g/mol
Topological Polar Surface Area: 20.2Ų
Heavy Atom Count: 4
Formal Charge: 0
Complexity: 7.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%

Density (g/ml) @ 20°C: 0.803-0.805
Refractive Index (20°C): 1.385-1.386
Boiling Range: 96-98°C
Non Volatile Matter: max. 0.002%
Acidity (C3H6O2): max. 0.001%
Water (KF): max. 0.005%
General Properties: Colorless, liquid
Odor: Light, spirituous
Intensity: 0,803 g/cm3
Boiling point: 98 °C
Melting point: -126 °C
Flash point: 22 °C
Vapor pressure: 1,99 kPa (20 °C)
Refraction index: 1.387 (20° C)
Solubility (aqueous): Completely miscible
Molecular Formula: CH3CH2CH2OH / n-PrOH
Cas Number: 71-23-8
Molecular Mass: 60.096 g/mol-1
Exact Mass: 60.057515 g/mol
Flashpoint: 77 °F / 22 °C
Boiling Point: 207 °F (at 760 mm Hg) / 97.2 °C

Melting Point: -195 °F / -126 °C
Vapour Pressure: 1.99 kPa (at 20 °C)
Water Solubility: miscible
Density: 0.803 g/mL
Log P: 0.329
Chemical formula: C3H8O
Molar mass: 60.096 g·mol−1
Appearance: Colorless liquid
Odor: mild, alcohol-like
Density: 0.803 g/mL
Melting point: −126 °C; −195 °F; 147 K
Boiling point: 97 to 98 °C; 206 to 208 °F; 370 to 371 K
Solubility in water: miscible
log P: 0.329
Vapor pressure: 1.99 kPa (at 20 °C)
Acidity (pKa): 16
Basicity (pKb): −2
Magnetic susceptibility (χ): −45.176·10−6 cm3/mol
Refractive index (nD): 1.387
Viscosity: 1.959 mPa·s (at 25 °C)
Dipole moment: 1.68 D

Thermochemistry:
Heat capacity (C): 143.96 J/(K·mol)
Std molar entropy (S⦵298): 192.8 J/(K·mol)
Std enthalpy of formation (ΔfH⦵298): −302.79…−302.29 kJ/mol
Std enthalpy of combustion (ΔcH⦵298): −2.02156…−2.02106 MJ/mol
Boiling point: 207°F
Molecular weight: 60.1
Freezing point/melting point: -196°F
Vapor pressure: 15 mmHg
Flash point: 72°F
Specific gravity: 0.81
Ionization potential: 10.15 eV
Lower explosive limit (LEL): 2.2%
Upper explosive limit (UEL): 13.7%
NFPA health rating: 1
NFPA fire rating: 3
NFPA reactivity rating: 0
CAS Number: 71-23-8
H.S. Code: 29051300.00
Chemical formula: CH3CH2CH2OH
Chemical Properties:
Melting point: -127 C
Boling point: 97 C

Specific gravity: 0.803
Solubility in water: Miscible
Vapour density: 2.07
Water Solubility: 391 g/L
logP: 0.21
logP: 0.36
logS: 0.81
pKa (Strongest Acidic): 16.85
pKa (Strongest Basic): -2
Physiological Charge: 0
Hydrogen Acceptor Count: 1
Hydrogen Donor Count: 1
Polar Surface Area: 20.23 Ų
Rotatable Bond Count: 1
Refractivity: 17.53 m³·mol⁻¹
Polarizability: 7.23 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: No
Veber's Rule: Yes
MDDR-like Rule: No

Formula: C3H8O
Formula mass: 60.10
Melting point, °C: -127
Boiling point, °C: 97
Vapor pressure, mmHg: 21 (25 C)
Vapor density (air=1): 2.07
Saturation Concentration: 1.97% (20 C)
Evaporization number: 1.3 (butyl acetate=1)
Critical temperature: 263
Critical pressure: 51.32
Density: 0.8053 g/cm3 (20 C)
Solubility in water: Miscible
Viscosity: 2.256 cp (20 C)
Surface tension: 23.75 g/s2 (20 C)
Refractive index: 1.3862 (20 C)
Dipole moment: 1.7 D (20 C)
Dielectric constant: 20.1 (25 C)
Partition coefficient, pKow: 0.25
Heat of fusion: 5.2 kJ/mol
Heat of vaporization: 47.5 kJ/mol
Heat of combustion: -2021.3 kJ/mol
Appearance: colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.80000 to 0.80500 @ 25.00 °C.
Pounds per Gallon - (est).: 6.657 to 6.698
Refractive Index: 1.38300 to 1.38800 @ 20.00 °C.

Melting Point: -127.00 to -126.00 °C. @ 760.00 mm Hg
Boiling Point: 97.00 to 98.00 °C. @ 760.00 mm Hg
Boiling Point: 52.00 to 53.00 °C. @ 100.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure: 26.316999 mmHg @ 25.00 °C. (est)
Vapor Density: 2.1 ( Air = 1 )
Flash Point: 59.00 °F. TCC ( 15.00 °C. )
logP (o/w): 0.250
Soluble in: alcohol, ether
water, 2.715e+005 mg/L @ 25 °C (est)
water, 1.00E+06 mg/L @ 25 °C (exp)
CAS Number: 71-23-8
Molecular Formula: C₃H₈O
Formula Weight: 60.09
Color (APHA): 15
Density 803 kg/m³
Boiling point: 206.6°F (97°C)
Melting point: -194.8°F (-126°C)
Molecular Formula: C3H8O
Molecular Weight: 60.0952 g/mol
Density: 6.5 lb / gal
Boiling Point: 207 °F at 760 mm Hg
Melting Point: -195.2 °F
Appearance : Colourless liquid
Odour: Similar to ethanol
Solubility: Miscible



FIRST AID MEASURES of n-PROPANOL:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of n-PROPANOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of n-PROPANOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of n-PROPANOL:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 120 min
*Body Protection:
Flame retardant antistatic protective clothing.
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of n-PROPANOL:
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
Take precautionaryNmeasures against static discharge.
*Hygiene measures:
Change contaminated clothing.
Wash hands after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of n-PROPANOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
1-propanol
propanol
Propan-1-ol
Propyl alcohol
n-propanol
71-23-8
n-Propyl alcohol
ethylcarbinol
Policosanol
optal
1-hydroxypropane
osmosol extra
Propylic alcohol
Propanol-1
1-Propyl alcohol
n-Propan-1-ol
Propanole
Propanolen
Alcohol, propyl
Propanoli
Ethyl carbinol
Alcool propilico
Alcool propylique
Propylowy alkohol
n-Propyl alkohol
Albacol
142583-61-7
propane-1-ol
1-PROPONOL
propylalcohol
Propyl alcohol, normal
Caswell No. 709A
FEMA No. 2928
FEMA Number 2928
Propyl alcohol (natural)
Propanol, 1-
Propyl alcohol, n-
Propyl-d7 alcohol
NSC 30300
CCRIS 3202
HSDB 115
n-Propylalkohol
EINECS 200-746-9
EPA Pesticide Chemical Code 047502
n-PrOH
UNII-96F264O9SV
BRN 1098242
DTXSID2021739
CHEBI:28831
AI3-16115
Propylan-propyl alcohol
96F264O9SV
Propyl-1,1-d2 alcohol
MFCD00002941
NSC-30300
UN1274
UN 1274
Propyl-3,3,3-d3 alcohol
DTXCID001739
PROPANOL-2,2-D2
62309-51-7
PROPYL ALCOHOL (PROPANOL)
EC 200-746-9
4-01-00-01413 (Beilstein Handbook Reference)
1-Propanol, anhydrous
1-Propanol-D1
Propanol; Propan-1-ol
POL
PROPANOL (EP MONOGRAPH)
PROPANOL [EP MONOGRAPH]
PROPYL ALCOHOL (MART.)
PROPYL ALCOHOL [MART.]
PROPYL-2-D1 ALCOHOL
1 Propanol
PROPANOL-1,1,2,2-D4
Ateromixol
Etilcarbinol
Hydroxypropane
ethyl methanol
n-propylalcohol
normal propanol
1-hidroxipropano
nPrOH
HOPr
PrOH
normal propyl alcohol
Caswell No 709A
Propan- 1- ol
70907-80-1
89603-83-8
N-Propanol ACS grade
PAL (CHRIS Code)
Propyl alcohol (8CI)
n-C3H7OH
1-Propanol, HPLC Grade
bmse000446
N-PROPANOL [HSDB]
PROPANOL [WHO-DD]
1-Propanol, >=99%
PROPYL ALCOHOL [MI]
Pesticide Code: 047502
PROPYL ALCOHOL [FCC]
WLN: Q3
CHEMBL14687
PROPYL ALCOHOL [FHFI]
PROPYL ALCOHOL [INCI]
1-PROPANOL [USP-RS]
n-Propanol (n-Propyl alcohol)
CCRIS 7209
1-Propanol, analytical standard
1-Propanol, JIS special grade
1-Propanol, >=99%, FG
1-Propanol, LR, >=99%
1-Propanol, >=99.80%
BDBM36153
1-Propanol, anhydrous, 99.7%
1-Propanol, p.a., 99.5%
Propanol [indefinite substitution]
1-Propanol, AR, >=99.5%
AMY11110
NSC30300
Tox21_302440
1-Propanol, Spectrophotometric Grade
LMFA05000101
n-Propanol or propyl alcohol, normal
NA1274
STL264225
1-Propanol, natural, >=98%, FG
Hydroxypropyl cellulose-SL (HPC-SL)
1-Propanol, >=99% (GC), purum
AKOS000249219
1-Propanol, for HPLC, >=99.5%
1-Propanol, for HPLC, >=99.9%
DB03175
LS-3067
1-Propanol, ACS reagent, >=99.5%
1-Propanol, HPLC grade, >=99.5%
CAS-71-23-8
1-Propanol, purum, >=99.0% (GC)
NCGC00255163-01
1-Propanol 100 microg/mL in Acetonitrile
PROPYL-1,1,3,3,3-D5 ALCOHOL
1-Propanol, SAJ first grade, >=99.0%
FT-0608280
FT-0608281
FT-0627482
P0491
1-Propanol, UV HPLC spectroscopic, 99.0%
EN300-19337
C05979
Q14985
A837125
InChI=1/C3H8O/c1-2-3-4/h4H,2-3H2,1H
J-505102
1-Propanol, for inorganic trace analysis, >=99.8%
VOC Mixture 669 500-5000 microg/mL in Triacetin
F0001-1829
5VQ
Propan-1-ol
n-Propyl alcohol
n-Propanol
n-PrOH
Ethyl carbinol
1-Hydroxypropane
Propionic alcohol
Propionyl alcohol
Propionylol
Propyl alcohol
Propylic alcohol
Propylol
Propyl alcohol
n-Propan-1-ol
n-Propanol
n-Propyl alcohol
Ethylcarbinol
Optal
Osmosol extra
Propanol
Propylic alcohol
1-Propyl alcohol
n-C3H7OH
1-Hydroxypropane
Propanol-1
Propan-1-ol
n-Propyl alkohol
Alcool propilico
Alcool propylique
Propanole
Propanolen
Propanoli
Propylowy alkohol
UN 1274
Propylan-propyl alcohol
NSC 30300
Alcohol, propyl
Propan-1-ol
n-Propyl alcohol
n-Propanol
n-PrOH
Ethylcarbinol
1-Hydroxypropane
Propionic alcohol
Propionyl alcohol
Propionylol
Propyl alcohol
Propylic alcohol
Propylol
CAS No. 71-23-8
n-Propyl alcohol
1-Propanol
Propanol
Propan-1-ol
Ethyl carbinol
1-Hydroxypropane
1 Propanol
1-Hydroxypropane
1-Propanol
1-Propyl alcohol
Alcohol, propyl
Ethyl carbinol
Ethylcarbinol
Hydroxypropane
N Propanol
N-Propan-1-ol
1-propanol
Propanol
Propan-1-ol
Propyl alcohol
n-propanol
n-Propyl alcohol
Ethylcarbinol
1-hydroxypropane
Optal
Propylic alcohol
Propanol-1
1-Propyl alcohol
n-Propyl alcohol
n-Propanol
Ethylcarbinol
1-Hydroxypropane
Propanol
Propionic alcohol
Propionyl alcohol
Propionylol
Propyl alcohol
Propylic alcohol
Propylol
1-Propanol
Propan-1-ol

N-PROPANOL
cas no 109-60-4 1-Propyl Acetate; Acetic acid, propyl ester; 1-Acetoxypropane; propyl acetate; n-Propyl ethanoate; Acetate de propyle normal; Octan propylu; Propyl ethanoate; Propylester kyseliny octove; Propylacetat; Acetato de propilo; Acétate de propyle;
N-PROPYL ACETATE
n-Propyl Acetate is an acetate ester obtained by the formal condensation of acetic acid with propanol.
n-Propyl Acetate has a role as a fragrance and a plant metabolite.
n-Propyl Acetate is functionally related to a propan-1-ol.


CAS Number: 109-60-4
EC Number: 203-686-1
MDL number: MFCD00009372
Molecular Formula: C5H10O2 / CH3COOCH2CH2CH3



SYNONYMS:
n-propyl acetate, acetic acid, propyl ester, propyl ethanoate, 1-acetoxypropane, n-propyl ethanoate, 1-propyl acetate, acetic acid n-propyl ester, octan propylu, propylacetate, acetic acid propyl ester, Acetic acid, propyl ester, Propyl acetate, 1-Acetoxypropane, 1-Propyl acetate, CH3COOCH2CH2CH3, Acetic acid n-propyl ester, n-Propyl ethanoate, Acetate de propyle normal, Octan propylu, Propyl ethanoate, Propylester kyseliny octove, UN 1276, Propyl ester of acetic acid, NSC 72025, n-Propanol acetate, n-propyl acetate, 1-propyl acetate, propyl acetate, npac, npa, np, normal propyl acetate, propyl ethanoate, n-propyl ethanoate, propyl ester, acetic acid, n-propyl ester, 1-acetoxypropane, Propyl acetate, n-Propyl ethanoate, n-Propyl acetate, Propylacetate, Acetic acid, propyl ester, n-Propyl ester of acetic acid, Normal propyl acetate, 1-propyl acetate, propyl acetate, 1-acetoxypropane, acetic acid propylacetate, n-propyl ester of acetic acid, 1-acetoxypropane, 1-propyl acetate, acetate of propyl, acetic acid normal-propyl ester, acetic acid n-propyl ester, acetic acid propyl ester, acetic acid, 1-propyl ester, acetic acid, propyl ester, normal propyl acetate, n-Propyl acetate, propylethanoate), Propyl acetate, n-Propyl ethanoate, n-Propyl acetate, Acetic acid, propyl ester, n-Propyl ester of acetic acid, propyl ethanoate, Propyl acetate, 109-60-4, N-PROPYL ACETATE, Acetic acid propyl ester, Propyl ethanoate, 1-Acetoxypropane, 1-Propyl acetate, n-Propyl ethanoate, Octan propylu, Acetic acid n-propyl ester, Acetate de propyle normal, n-Propyl acetate (natural), Acetic acid propyl ester, FEMA No. 2925, Propylester kyseliny octove, NSC 72025, HSDB 161, n-propanol acetate, EINECS 203-686-1, Acetic acid n-propyl ester, UNII-4AWM8C91G6, BRN 1740764, 4AWM8C91G6, DTXSID6021901, CHEBI:40116, AI3-24156, NSC-72025, DTXCID301901, ACETIC ACID,PROPYL ESTER, EC 203-686-1, 4-02-00-00138 (Beilstein Handbook Reference), PROPYL ACETATE (USP-RS), PROPYL ACETATE [USP-RS], UN1276, Propyl acetate, 99%, CH3COOCH2CH2CH3, Acetic acid-n-propyl ester, Propyl ester of acetic acid, PROPYL ACETATE [MI], FEMA NUMBER 2935, SCHEMBL14991, PROPYL ACETATE [FCC], WLN: 3OV1, CHEMBL44857, PROPYL ACETATE [FHFI], Propyl acetate, >=99.5%, Propyl acetate, >=98%, FG, N-PROPYL ACETATE [HSDB], N-Propyl acetate LBG-64752, Propyl acetate, analytical standard, ACETIC ACID, N-PROPYL ETHER, NSC72025, Tox21_202012, MFCD00009372, STL280317, AKOS008949448, DB01670, UN 1276, NCGC00249148-01, NCGC00259561-01, CAS-109-60-4, LS-13075, DB-040874, A0044, NS00003289, Propyl acetate, natural, >=97%, FCC, FG, n-Propyl acetate [UN1276] [Flammable liquid], Q415750, Analytical Reagent, inverted exclamation markY99.0%, J-002310, InChI=1/C5H10O2/c1-3-4-7-5(2)6/h3-4H2,1-2H, Propyl acetate, United States Pharmacopeia (USP) Reference Standard, Propyl Acetate, Pharmaceutical Secondary Standard; Certified Reference Material, Propyl acetate, Propyl ethanoate, Acetic acid propyl ester, n-Propyl ethanoate, n-Propyl acetate, n-Propyl ester of acetic acid, 1-Acetoxypropane, 1-Propyl acetate, Acetate de propyle normal, Acetic acid n-propyl ester, Acetic acid, propyl ester, CH3COOCH2CH2CH3, NSC 72025, Octan propylu, Propyl ester of acetic acid, Propyl ethanoate, Propylester kyseliny octove, UN 1276, ethanoic acid propyl ester, n-Propanol acetate, n-Propyl ethanoate



n-Propyl Acetate appears as a clear colorless liquid with a pleasant odor.
Flash point of n-Propyl Acetate is 58 °F.
n-Propyl Acetate's less dense than water, and Vapors are heavier than air.


n-Propyl Acetate is an acetate ester obtained by the formal condensation of acetic acid with propanol.
n-Propyl Acetate has a role as a fragrance and a plant metabolite.
n-Propyl Acetate is functionally related to a propan-1-ol.


n-Propyl Acetate is a natural product found in Zingiber mioga, Saussurea involucrata, and other organisms with data available.
n-Propyl Acetate is a metabolite found in or produced by Saccharomyces cerevisiae.
n-Propyl Acetate, also known as propyl ethanoate, is an organic compound. Nearly 20,000 tons are produced annually for use as a solvent.


This colorless liquid, n-Propyl Acetate, is known by its characteristic odor of pears.
Due to this fact, n-Propyl Acetate is commonly used in fragrances and as a flavor additive.
n-Propyl Acetate is formed by the esterification of acetic acid and propan-1-ol, often via Fischer–Speier esterification, with sulfuric acid as a catalyst and water produced as a byproduct


n-Propyl Acetate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
n-Propyl Acetate is a colorless, volatile solvent with an odor similar to acetone.


n-Propyl Acetate has good solvency power for many natural and synthetic resins.
n-Propyl Acetate is miscible with many organic solvents.
Applications of n-Propyl Acetate: Coatings, Wood lacquers, Aerosol sprays, Nail care, Cosmetic / personal care solvent, Fragrance solvent, Process solvent, and Printing inks (especially flexographic and special screen).


n-Propyl Acetate (also known as 1-propyl acetate, propyl acetate, 1-acetoxypropane, acetic acid) is an organic compound with a molecular formula of C5H10O2 / CH3COOCH2CH2CH3.
n-Propyl Acetate is a clear, colourless ester that has a distinguishable acetate odour, is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters) but only slightly miscible in water.


n-Propyl Acetate is a clear, colourless ester that has a distinguishable acetate odour, is highly miscible with all common organic solvents including alcohols, ketones, glycols and esters but only slightly miscible in water.
n-Propyl Acetate is an organic compound with a molecular formula of C5H10O2.


n-Propyl Acetate is a clear, colorless liquid that has a distinguishable acetate odor.
n-Propyl Acetate is highly flammable with a flash point of 14° C and a flammability rating of 3.
n-Propyl Acetate is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters) but has only slight miscibility in water.


n-Propyl Acetate is a clear, colourless liquid with a distinctive, pleasant fruity odour.
n-Propyl Acetate is readily miscible with most organic solvents such as alcohol, ketones, glycols and esters, but it has only limited miscibility with water.


n-Propyl Acetate is an ester with an average evaporation rate and high degree of solubility in the major resins on the market, such as nitrocellulose, and synthetic and natural resins.
n-Propyl Acetate is miscible with hydrocarbons, ketones, esters, alcohols and ethers, and it has low water solubility.


n-Propyl Acetate acts as a clear, colorless, volatile solvent for coatings, printing inks and chemical downstream industries.
n-Propyl Acetate possesses a characteristic odor reminiscent of acetone and a good solvent power for numerous natural and synthetic resins.
n-Propyl Acetate exhibits miscibility with many common solvents, e.g. alcohols, ketones, ethers, aldehydes, glycols and glycol ethers, but sparingly soluble in water.


n-Propyl Acetate, also known as propyl ethanoate, is a chemical compound used as a solvent and an example of an ester.
This clear, colorless liquid, n-Propyl Acetate, is known by its characteristic odor of pears.
n-Propyl Acetate is formed by the esterification of acetic acid and 1-propanol (known as a condensation reaction), often via Fischer–Speier esterification, with sulfuric acid as a catalyst and water produced as a byproduct.


Acetic acid propyl ester, also known as “propyl acetate” or “n-propyl acetate”, naturally exists in strawberries, bananas and tomatoes.
n-Propyl Acetate is synthetically produced by having acetic acid and 1-propanol undergoing esterification reaction.
n-Propyl Acetate is a colorless transparent liquid at room temperature with typical ester properties.


n-Propyl Acetate has a special fruity odor and can be dissolved in both ethanol and ethyl ether.
N-propyl acetate is a colorless, volatile solvent with an odor similar to acetone.
n-Propyl Acetate has good solvency power for many natural and synthetic resins.


n-Propyl Acetate is miscible with many organic solvents.
n-Propyl Acetate is an organic compound with a molecular formula of C5H10O2.
This product is a clear, colourless liquid, n-Propyl Acetate, that has a distinguishable acetate odor.


n-Propyl Acetate is highly flammable and it is abundantly miscible with all common organic solvents (alcohols, ketones, glycols,
esters) but has only slight miscibility in water.
n-Propyl Acetate is a highly flammable organic compound.


The main user end markets for n-Propyl Acetate are the printing, coatings, lacquers, cosmetic and flavouring industries.
n-Propyl Acetate is a colorless liquid with a mild, fruity odor.
n-Propyl Acetate is an active solvent for nitrocellulose, cellulose acetate butyrate, polyester, alkyd, and acrylic resins.


n-Propyl Acetate has a medium evaporation rate and is a non-HAP solvent.
n-Propyl Acetate promotes flow and leveling in a variety of formulations.



USES and APPLICATIONS of N-PROPYL ACETATE:
n-Propyl Acetate is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
n-Propyl Acetate is used as a solvent.
n-Propyl Acetate plays an important role in the printing inks industry are flexographic and special screen printing inks.


n-Propyl Acetate is widely used in fragrances and as a flavor additive due to its odor.
n-Propyl Acetate acts as a good solvent for cellulose nitrate, acrylates, alkyd resins, rosin, plasticizers, waxes, oils and fats.
n-Propyl Acetate is used in the following products: lubricants and greases, coating products, anti-freeze products, perfumes and fragrances, adhesives and sealants, washing & cleaning products, leather treatment products, cosmetics and personal care products and polishes and waxes.


Other release to the environment of n-Propyl Acetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).


n-Propyl Acetate is used in the following products: coating products, laboratory chemicals, lubricants and greases, washing & cleaning products, inks and toners and metal working fluids.
n-Propyl Acetate is used in the following areas: building & construction work and scientific research and development.


Other release to the environment of n-Propyl Acetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).


n-Propyl Acetate is used for the manufacture of: , fabricated metal products, electrical, electronic and optical equipment and machinery and vehicles.
n-Propyl Acetate is commonly used as a solvent, in fragrances and as a flavor additive.
n-Propyl Acetate is used as a solvent.


n-Propyl Acetate plays an important role in the printing inks industry are flexographic and special screen printing inks.
n-Propyl Acetate is widely used in fragrances and as a flavor additive due to its odor.
n-Propyl Acetate acts as a good solvent for cellulose nitrate, acrylates, alkyd resins, rosin, plasticizers, waxes, oils and fats.


n-Propyl Acetate is used in the following products: coating products, inks and toners and cosmetics and personal care products.
Release to the environment of n-Propyl Acetate can occur from industrial use: formulation of mixtures and manufacturing of the substance.
n-Propyl Acetate is used in the following products: coating products, washing & cleaning products, inks and toners, lubricants and greases and metal working fluids.


n-Propyl Acetate has an industrial use resulting in manufacture of another substance (use of intermediates).
n-Propyl Acetate is used for the manufacture of: chemicals.
Release to the environment of n-Propyl Acetate can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.


Release to the environment of n-Propyl Acetate can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
The major use of n-Propyl Acetate is as a solvent in the coatings and printing industries.


n-Propyl Acetate is a good solvent for these industries because it has the ability to thin many other organic compounds.
n-Propyl Acetate dissolves a host of resins which make it a suitable solvent for wood lacquers and industrial finishes.
Within the printing industry n-Propyl Acetate is mainly used in flexographic and special screening prints.


n-Propyl Acetate is also used in aerosol sprays, nail care and as a fragrance solvent.
n-Propyl Acetate can also be used as a flavouring additive due to its odour similar to pears. n-Propyl Acetate is used printing, coatings, lacquers, cosmetic and flavouring, solvent.


The main user end markets of n-Propyl Acetate are the printing, coatings, lacquers, cosmetic and flavouring industries.
n-Propyl Acetate is used Lacquer thinners, Wood lacquers, Coatings, Printing inks, Aerosol sprays, Personal care products, Fragrances, Cosmetics, Personal care, and Pharmaceuticals.


n-Propyl Acetate is commonly used as a solvent in coatings and printing inks.
n-Propyl Acetate is used in formulations for paints and thinners for different applications, including printing inks (rotogravure and flexography), industrial coatings , original automotive paints and car refinishing .


n-Propyl Acetate is used in fragrances and as a flavor additive.
n-Propyl Acetate is used for coatings applications like wood lacquers and industrial finishes and for printing inks applications like flexographic and special screen inks.


In printing inks, n-Propyl Acetate also stands out for its low retention in flexible polyethylene and polypropylene films.
n-Propyl Acetate is primarily used as a solvent in the manufacture of paints and coatings because of its ability to thin many other organic compounds.
n-Propyl Acetate has the power to dissolve a wide range of resins, which also makes it highly suitable as a solvent for wood lacquers and industrial finishes.


n-Propyl Acetate is widely used in the printing industry, mainly for flexographic and screen printing inks.
n-Propyl Acetate is also used as a solvent in perfumes and is found as an ingredient in aerosol sprays, nail care products and cosmetics.
n-Propyl Acetate is used as an intermediate in organic chemistry of pharmaceutical compounds.


n-Propyl Acetate is also used as a flavouring additive on account of its fruity odour, which is similar to pears.
Because n-Propyl Acetate has the ability to dissolve a host of resins, it is a particularly useful solvent for wood lacquers and industrial finishes.
Within the printing industry n-Propyl Acetate is mainly used in flexographic prints.


n-Propyl Acetate is also used in aerosol sprays, nail care and as a fragrance solvent.
n-Propyl Acetate has a pear-like odour which enables it to be used as a flavouring additive, too.
n-Propyl Acetate is used as a solvent and as a flavor additive and as an odorant in fragrances.


n-Propyl Acetate is commonly used as a solvent in coatings and printing inks.
n-Propyl Acetate is a compound often used in fragrances and as a flavor additive.
n-Propyl Acetate is used auto OEM, Auto refinish, Commerical printing inks, General industrial coatings, and Paints & coatings.



SOLUBILITY OF N-PROPYL ACETATE:
n-Propyl Acetate is miscible with alcohols, ketones, aldehydes, ethers, glycols and glycol ethers.
n-Propyl Acetate is slightly soluble in water.



STORAGE AND HANDLING OF N-PROPYL ACETATE:
n-Propyl Acetate should be stored in a tightly-closed containerin a cool, dry, well-ventilated place away from direct sunlight, heat, sources of ignition and incompatible materials such as strong oxidizers, acids and bases.



BENEFITS OF N-PROPYL ACETATE:
*ood solvency power
*Miscible with many common organic solvents.
*Clear and Colourless
*Acetate odour
*Flammable
*Miscible with common solvents
*Slightly miscible with water



HOW IS N-PROPYL ACETATE PRODUCED?
The primary and most common method for chemically manufacturing n-Propyl Acetate is the direct esterification of 1-propanol and acetic acid which are heated in the presence of a strong acid, such as sulfuric or methanesulfonic acid.
An alternate method involves the ester interchange of 1-propanol with ethyl acetate.



STORAGE AND DISTRIBUTION OF N-PROPYL ACETATE:
A chemical wholesaler would have a bulk petrochemical storage facility to regulate this product.
Storage is normally in a cool, dry and well ventilated facility away from oxidising agents.
n-Propyl Acetate should be kept out of direct sunlight, heat and open flames.
Solvents such as n-Propyl Acetate should be stored in drummed containers such as isotanks made of stainless steel, aluminium or carbon steel.



KEY ATTRIBUTES OF N-PROPYL ACETATE:
*Good solvent activity
*High electrical resistance
*Inert - Nonfood use
*Low MIR value
*Low surface tension
*Low water solubility
*Medium evaporation rate
*Mild odor
*Non-HAP
*Non-SARA
*Predicted to be readily biodegradable
*REACH compliant
*Urethane grade



PROPERTIES OF N-PROPYL ACETATE:
n-Propyl Acetate is a highly flammable, colourless liquid with a distinctive pear odour and a flash point of 11.8° C.
n-Propyl Acetate is completely miscible with water and miscible with most organic solvents, too.



PHYSICAL and CHEMICAL PROPERTIES of N-PROPYL ACETATE:
Molecular Weight: 102.13 g/mol
XLogP3: 1.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 3
Exact Mass: 102.068079557 g/mol
Monoisotopic Mass: 102.068079557 g/mol
Topological Polar Surface Area: 26.3 Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 59.1

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical Formula: C5H10O2
Molar Mass: 102.133 g·mol−1
Appearance: Colorless liquid
Odor: Mild, fruity
Density: 0.89 g/cm3
Melting Point: −95 °C (−139 °F; 178 K)

Boiling Point: 102 °C (216 °F; 375 K)
Solubility in water: 18.9 g/L
Vapor Pressure: 25 mmHg (20 °C)
Magnetic Susceptibility (χ): −65.91·10−6 cm3/mol
CAS Number: 109-60-4
Molecular Mass: 102.06808 g/mol
Flashpoint: 58 °F / 14.4 °C
Boiling Point: 214.9 °F at 760 mm Hg
Melting Point: -139 °F / -95 °C
Vapour Pressure: 67.21 mm Hg
Water Solubility: g/100ml at 16 °C: 1.6
Density: 0.886 at 68 °F
EC Index Number: 607-024-00-6

EC Number: 203-686-1
Hill Formula: C₅H₁₀O₂
Chemical Formula: CH₃COOCH₂CH₂CH₃
Molar Mass: 102.13 g/mol
HS Code: 2915 39 31
Boiling Point: 101.5 °C (1013 hPa)
Density: 0.89 g/cm3 (20 °C)
Explosion Limit: 1.7 - 8% (V)
Flash Point: 11.8 °C
Ignition Temperature: 430 °C
Melting Point: -95 °C
Vapor Pressure: 33 hPa (20 °C)
Solubility: 21.2 g/l
Physical State: Clear, liquid
Color: Colorless
Odor: Mild

Melting Point/Freezing Point: -95°C (lit.)
Initial Boiling Point and Boiling Range: 102°C (lit.)
Flammability (Solid, Gas): No data available
Upper/Lower Flammability or Explosive Limits:
Upper explosion limit: 8% (V),
Lower explosion limit: 1.7% (V)
Flash Point: 11.8°C - closed cup
Autoignition Temperature: No data available
Decomposition Temperature: No data available
pH: No data available
Viscosity: Kinematic viscosity - No data available,
Dynamic viscosity - 0.58 mPa.s at 20°C
Water Solubility: 18.9 g/L at 20°C - soluble
Partition Coefficient (n-octanol/water): log Pow: 1.4 (ECHA)

Vapor Pressure: 33 hPa at 20°C
Density: 0.888 g/cm3 at 25°C - lit.
Relative Vapor Density: 3.53 (Air = 1.0)
Particle Characteristics: No data available
Explosive Properties: No data available
Oxidizing Properties: None
Other Safety Information:
Surface tension - 67.5 mN/m at 20.1°C
CAS: 109-60-4
Molecular Formula: C5H10O2
Molecular Weight (g/mol): 102.13
MDL Number: MFCD00009372
InChI Key: YKYONYBAUNKHLG-UHFFFAOYSA-N
PubChem CID: 7997

ChEBI: CHEBI:40116
IUPAC Name: propyl acetate
SMILES: CCCOC(C)=O
Melting Point: -95°C
Boiling Point: 102°C
Vapor Density: 3.5
Formula Weight: 102.13 g/mol
Vapor Pressure: 33 mbar at 20°C
Physical Form: Liquid
Physical Description: Colorless liquid with a mild, fruity odor.
Boiling Point: 215°F
Molecular Weight: 102.2
Freezing Point/Melting Point: -134°F
Vapor Pressure: 25 mmHg
Flash Point: 55°F

Specific Gravity: 0.84
Ionization Potential: 10.04 eV
Lower Explosive Limit (LEL): 1.7% at 100°F
Upper Explosive Limit (UEL): 8%
NFPA Health Rating: 1
NFPA Fire Rating: 3
NFPA Reactivity Rating: 0
Assay: 98.5%
Appearance (Form): Liquid
Appearance (Color): Colorless
Melting Point: -95°C (lit.)
Density: 0.888 g/mL at 25°C (lit.)

Appearance: colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity: 0.88000 to 0.90000 @ 25.00 °C
Pounds per Gallon - (est): 7.322 to 7.489
Refractive Index: 1.37800 to 1.38800 @ 20.00 °C
Melting Point: -95.00 °C @ 760.00 mm Hg
Boiling Point: 101.00 to 102.00 °C @ 760.00 mm Hg; 32.00 to 33.00 °C @ 50.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure: 35.223000 mmHg @ 25.00 °C (est)
Vapor Density: 3.5 (Air = 1)
Flash Point: 55.00 °F TCC (12.78 °C)
logP (o/w): 1.240
Soluble in: alcohol; water, 18900 mg/L @ 20 °C (exp)
Insoluble in: water

Name: ACETIC ACID, PROPYL ESTER
Exact Mass: 102.068079560 u
Formula: C5H10O2
InChI: InChI=1S/C5H10O2/c1-3-4-7-5(2)6/h3-4H2,1-2H3
InChIKey: YKYONYBAUNKHLG-UHFFFAOYSA-N
Molecular Weight: 102.133 g/mol
Nominal Mass: 102 u
Number of Peaks: 11
SMILES: CC(OCCC)=O
SPLASH: splash10-0006-9000000000-e4cb064feb4370ff0b01



FIRST AID MEASURES of N-PROPYL ACETATE:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of N-PROPYL ACETATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of N-PROPYL ACETATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-PROPYL ACETATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment.
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 120 min
*Body Protection:
Flame retardant antistatic protective clothing.
*Respiratory protection:
Recommended Filter type: Filter A (acc. to DIN 3181)
-Control of environmental exposure:
Do not let product enter drains



HANDLING and STORAGE of N-PROPYL ACETATE:
-Precautions for safe handling:
Advice on safe handling
Work under hood.
*Advice on protection against fire and explosion:
Take precautionary measures against static discharge.
*Hygiene measures:
Change contaminated clothing.
Wash hands after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Keep away from heat and sources of ignition.



STABILITY and REACTIVITY of N-PROPYL ACETATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .


N-PROPYL ACETATE
N-Propyl Acetate, also known as propyl ethanoate, is an organic compound.
Nearly 20,000 tons are produced annually for use as a solvent.
This colorless liquid is known by its characteristic odor of pears.

CAS: 109-60-4
MF: C5H10O2
MW: 102.13
EINECS: 203-686-1

Synonyms
PROPYL ACETATE;PROPYL ETHANOATE;N-PROPYL ACETATE;1-Acetoxypropane;1-Propyl acetate;1-propylacetate;octanpropylu;octanpropylu(polish);Propyl acetate;109-60-4;N-PROPYL ACETATE;Aceticacid, propyl ester;Propyl ethanoate;1-Acetoxypropane;1-Propyl acetate;n-Propyl ethanoate;Octan propylu;Acetic acid n-propyl ester;Acetate de propyle normal;n-Propyl acetate (natural);Acetic acid propyl ester;FEMA No. 2925;Propylester kyseliny octove;NSC 72025;HSDB 161
;n-propanol acetate;EINECS 203-686-1;Acetic acid, n-propyl ester;UNII-4AWM8C91G6;BRN 1740764;4AWM8C91G6;DTXSID6021901;CHEBI:40116;AI3-24156;NSC-72025;DTXCID301901;ACETIC ACID,PROPYL ESTER;EC 203-686-1;4-02-00-00138 (Beilstein Handbook Reference);PROPYL ACETATE (USP-RS);PROPYL ACETATE [USP-RS];Octan propylu [Polish];Acetate de propyle normal [French];Propylester kyseliny octove [Czech];UN1276;Propyl acetate, 99%;CH3COOCH2CH2CH3;Acetic acid-n-propyl ester;Propyl ester of acetic acid;PROPYL ACETATE [MI];FEMA NUMBER 2935;SCHEMBL14991;PROPYL ACETATE [FCC];WLN: 3OV1;CHEMBL44857;PROPYL ACETATE [FHFI];Propyl acetate, >=99.5%;Propyl acetate, >=98%, FG;N-PROPYL ACETATE [HSDB];N-Propyl acetate LBG-64752;Propyl acetate, analytical standard;ACETIC ACID, N-PROPYL ETHER;NSC72025;Tox21_202012;MFCD00009372;STL280317;AKOS008949448;DB01670;UN 1276;NCGC00249148-01;NCGC00259561-01;CAS-109-60-4;LS-13075;DB-040874;A0044;NS00003289;Propyl acetate, natural, >=97%, FCC, FG;n-Propyl acetate [UN1276] [Flammable liquid];Q415750;Analytical Reagent, inverted exclamation markY99.0%;J-002310;InChI=1/C5H10O2/c1-3-4-7-5(2)6/h3-4H2,1-2H;Propyl acetate, United States Pharmacopeia (USP) Reference Standard;Propyl Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

Due to this fact, N-Propyl Acetate is commonly used in fragrances and as a flavor additive.
N-Propyl Acetate is formed by the esterification of acetic acid and propan-1-ol, often via Fischer–Speier esterification, with sulfuric acid as a catalyst and water produced as a byproduct.
N-Propyl Acetate, also known as propyl ethanoate, is an organic compound with a molecular formula of C5H10O2.
N-Propyl Acetate is a clear and colourless liquid with with a mild fruity odor.
N-Propyl Acetate is highly flammable with a flash point of 14°C and a flammability rating of 3.
N-Propyl Acetate is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters) but has only slight miscibility in water.
N-Propyl Acetate is found in apple and formed by the esterification of acetic acid and 1-propanol (known as acondensation reaction), often via Fischer–Speier esterification, with sulfuric acid as a catalyst and water produced as a byproduct.

N-Propyl Acetate is primarily intended as a solvent in the coatings and printing inks industries.
N-Propyl Acetate is widely used in fragrances and as a flavor additive due to its odor.
N-Propyl Acetate also acts as a good solvent for cellulose nitrate, acrylates, alkyd resins, rosin, plasticizers, waxes, oils and fats.
N-Propyl Acetate is an acetate ester obtained by the formal condensation of acetic acid with propanol.
N-Propyl Acetate has a role as a fragrance and a plant metabolite.
N-Propyl Acetate derives from a propan-1-ol.
Normal propyl acetate (also known as n-propyl acetate, 1-propyl acetate, propyl acetate, 1-acetoxypropane, acetic acid) is an organic compound with a molecular formula of C5H10O2 / CH3COOCH2CH2CH3.
N-Propyl Acetate is a clear, colourless ester that has a distinguishable acetate odour, is highly flammable, highly miscible with all common organic solvents (alcohols, ketones, glycols, esters) but only slightly miscible in water.

N-Propyl Acetate Chemical Properties
Melting point: -95 °C (lit.)
Boiling point: 102 °C (lit.)
Density: 0.888 55 °F
Storage temp.: Store below +30°C.
Solubility water: soluble
Form: Liquid
Specific Gravity: 0.889 (20/4℃)
Color: APHA: ≤15
Odor: Mild fruity.
Odor Type: fruity
Odor Threshold: 0.24ppm
Explosive limit: 1.7%, 37°F
Water Solubility: 2g/100 mL (20 ºC)
JECFA Number: 126
Merck: 14,7841
BRN: 1740764
Henry's Law Constant: 5.54 at 37 °C (static headspace-GC, van Ruth et al., 2001)
Exposure limits TLV-TWA 200 ppm (~840 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 250 ppm (~1050 mg/m3) (ACGIH); IDLH 8000 ppm (NIOSH).
Dielectric constant: 6.3(20℃)
Stability: Stable. Highly flammable.
May react violently with oxidizing agents.
May form explosive mixtures with air.
Incompatible with strong oxidizing agents, acids, bases.
LogP: 1.4 at 25℃
CAS DataBase Reference: 109-60-4(CAS DataBase Reference)
NIST Chemistry Reference: N-Propyl Acetate (109-60-4)
EPA Substance Registry System: N-Propyl Acetate (109-60-4)

N-Propyl Acetate has a fruity (pear–raspberry) odor with a pleasant, bittersweet flavor reminiscent of pear on dilution.
The Odor Threshold is 70 milligram per cubic meter and 2.8 milligram per cubic meter (New Jersey Fact Sheet).
Clear, colorless, flammable liquid with a pleasant, pear-like odor.
Experimentally determined detection and recognition odor threshold concentrations were 200 μg/m3 (48 ppbv) and 600 μg/m3 (140 ppbv), respectively.
An odor threshold concentration of 240 ppbv was determined by a triangular odor bag method.
Cometto-Muiz and Cain (1991) reported an average nasal pungency threshold concentration of 17,575 ppmv.

Uses
N-Propyl Acetate is used as a solvent for cellulose derivatives, plastics, and resins; in flavors and perfumes; and in organic synthesis.

Preparation
N-Propyl Acetate is formed by the esterification of acetic acid and 1-propanol with sulfuric acid as a catalyst and water produced as a byproduct or By direct acetylation of propyl alcohol.

Production Methods
N-Propyl Acetate is manufactured from acetic acid and a mixture of propene and propane in the presence of a zinc chloride catalyst.
N-Propyl Acetate is used as a solvent for nitrocellulose- based lacquers, waxes, polyamide inks, acrylic inks, and insecticide formulations.
Manufacturers include Eastman Chemical Company, Hoechst Celanese Corporation, and Union Carbide Corporation.

Health Hazard
The acute toxicity of N-Propyl Acetate is low in test animals.
The toxicity, however, is slightly greater than ethyl acetate andisopropyl acetate.
Exposure to its vaporsproduces irritation of the eyes, nose, andthroat and narcotic effects.
A 5-hour expo sure to 9000- and 6000-ppm concentrationsproduced narcotic symptoms in cats andmice, respectively.
A 4-hour exposure to 8000 ppm was lethalto rats.
Ingestion of the liquid can cause narcotic action.
A high dose can cause death.
Adose of 3000 mg/kg by subcutaneous admin istration was lethal to cats.
The liquid maycause mild irritation upon contact with skin.
N-PROPYL ALCOHOL (N-PROPANOL)

N-propyl alcohol, also known as n-propanol or 1-propanol, is a primary alcohol with the molecular formula C3H8O.
N-propyl alcohol (N-Propanol) is an isomer of isopropyl alcohol (2-propanol) and ethanol (ethyl alcohol).
The term "n" in N-propyl alcohol indicates that the propyl group is linear, meaning the carbon atoms are arranged in a straight chain.

CAS Number: 71-23-8
EC Number: 200-746-9

Chemical Formula: C3H8O
Structural Formula: CH3-CH2-CH2-OH

1-Propanol, Propyl alcohol, N-propyl alcohol, Propionic alcohol, Propylol, Ethylcarbinol, Primine alcohol, Propyl hydroxide, Propan-1-ol, NPA, Propylic alcohol, Normal propanol, Propyl alcohol, 1-Hydroxypropane, Propylic hydroxide, Propyl hydrate, Propanol-1, Propylicol, Propyl oxide, Propyl hydroxide, Propionic alcohol, Mono-propyl alcohol, 1-Aminoethane, Normal propyl alcohol, Propionic alcohol, Propylol, Ethyl methyl carbinol, Ethyl carbinol, Primine alcohol, Propylcarbinol, Alcool propylique, Propol, Ethylmethanol, Propanol, 1-Propyl alcohol, Propanol-1, Propyl alcohol, 1-Propanol, Propan-1-ol, 1-Hydroxypropane, Propyl hydrate, Propylic hydroxide, Propyl alcohol, normal, Propyl alcohol, straight, Propyl alcohol, linear, Propyl alcohol, normal, Propanol, Propyl carbinol, Propyl alcohol, primary, Propylol, 1-Aminoethane, N-Propyl alcohol, Propionic alcohol, 1-Hydroxypropane, Propyl hydrate, Propylol, 1-Aminoethanol, Propyl hydroxide, N-Propanol, Propylic hydroxide



APPLICATIONS


N-propyl alcohol (N-Propanol) is employed as a solvent in industries such as coatings, inks, and adhesives.
N-propyl alcohol (N-Propanol) plays a vital role in the printing industry, contributing to the formulation of inks.
Its solvency properties make it a key component in the production of adhesives.

N-propyl alcohol (N-Propanol) serves as a significant intermediate in the synthesis of various organic compounds.
As an effective cleaning agent, N-propyl alcohol (N-Propanol) is used to remove contaminants from surfaces.
In laboratories, it acts as a versatile solvent for reactions and extractions.

N-propyl alcohol (N-Propanol) may be utilized as a fuel additive or in the production of biodiesel.
Pharmaceutical industries use it as a solvent for preparing medications.

N-propyl alcohol (N-Propanol) is involved in the production of diverse chemicals and pharmaceuticals.
Its linear propyl chain sets it apart from isopropyl alcohol, influencing its chemical behavior.

N-propyl alcohol (N-Propanol) is crucial in the synthesis of flavor and fragrance compounds.
Contributing to the creation of plasticizers, it plays a role in plastics manufacturing.
In certain formulations, it serves as a fuel additive, impacting combustion characteristics.

Controlled evaporation is a desirable property in processes where 1-Propanol is used.
N-propyl alcohol (N-Propanol) may find application in the fuel industry for specific purposes, including fuel formulations.
As a chemical reduction reagent, it participates in certain chemical reactions.

N-propyl alcohol (N-Propanol) contributes to esterification processes, aiding in the synthesis of esters.
N-propyl alcohol (N-Propanol) is utilized in the production of biodiesel and other fuel formulations.
N-propyl alcohol (N-Propanol) can influence specific properties in the manufacturing of plastics.

Its properties make it suitable for use in personal care products such as lotions and creams.
In certain applications, N-propyl alcohol (N-Propanol) may serve as a flame retardant additive.
As a solvent for pharmaceutical formulations, it aids in drug delivery.

In the paint and coatings industry, it is used as a solvent to control viscosity.
Its versatility extends to surface cleaning in various industrial and commercial settings.
N-propyl alcohol (N-Propanol) contributes to the synthesis of diverse chemical derivatives used in various applications.

N-propyl alcohol (N-Propanol) is extensively utilized as a solvent in the formulation of coatings, adhesives, and printing inks.
Its solvency properties make it an essential component in the manufacturing of adhesives.
N-propyl alcohol (N-Propanol)'s role as a cleaning agent extends to various industrial and commercial applications, effectively removing contaminants from surfaces.
In laboratory settings, N-propyl alcohol (N-Propanol) acts as a versatile solvent, finding use in reactions and extractions.
Its effectiveness as a fuel additive or in the production of biodiesel contributes to the fuel industry.
The pharmaceutical sector relies on N-propyl alcohol (N-Propanol) as a solvent for the preparation of medications.

Its involvement in the production of diverse chemicals underscores its significance in chemical manufacturing.
The linear propyl chain distinguishes it from isopropyl alcohol, impacting its chemical behavior.
The synthesis of flavor and fragrance compounds benefits from 1-Propanol's versatile properties.

Contributing to the creation of plasticizers, it plays a role in plastics manufacturing.
In certain formulations, N-propyl alcohol (N-Propanol) serves as a fuel additive, influencing combustion characteristics.

Controlled evaporation is a valuable property in processes where 1-Propanol is employed.
N-propyl alcohol (N-Propanol) may find application in the fuel industry for specific purposes, including fuel formulations.

As a chemical reduction reagent, it participates in specific chemical reactions.
N-propyl alcohol (N-Propanol)'s contribution to esterification processes aids in the synthesis of esters.
N-propyl alcohol (N-Propanol)'s involvement in the production of biodiesel and other fuel formulations highlights its role in renewable energy sources.

Specific properties influenced by 1-Propanol play a role in the manufacturing of plastics.
Its suitability for personal care products, such as lotions and creams, is attributed to its beneficial properties.

In flame retardant applications, 1-Propanol may serve as an effective additive.
Its role as a pharmaceutical solvent aids in the efficient delivery of drugs.

The paint and coatings industry benefits from 1-Propanol as a solvent, enabling viscosity control.
Its versatility extends to surface cleaning in various industrial and commercial settings. N-propyl alcohol (N-Propanol)'s impact on the synthesis of diverse chemical derivatives underscores its importance in various applications.


N-propyl alcohol (N-Propanol) has many different uses:

Solvent in Coatings:
N-propyl alcohol (N-Propanol) is widely used as a solvent in the formulation of paints, varnishes, and coatings.

Ink Formulation:
N-propyl alcohol (N-Propanol) finds application in the printing industry for the formulation of inks.

Adhesive Manufacturing:
N-propyl alcohol (N-Propanol) is utilized in the production of adhesives due to its solvency properties.

Chemical Intermediate:
N-propyl alcohol (N-Propanol) serves as a crucial chemical intermediate in the synthesis of various organic compounds.

Cleaning Agent:
N-propyl alcohol (N-Propanol) is employed as an effective cleaning agent, removing contaminants from surfaces.

Laboratory Solvent:
In laboratories, it acts as a solvent for various reactions and extractions.

Fuel Additive:
N-propyl alcohol (N-Propanol) may be used as a fuel additive or in the production of biodiesel.

Pharmaceutical Synthesis:
In pharmaceutical industries, N-propyl alcohol (N-Propanol) is utilized as a solvent for the preparation of medications.


N-propyl alcohol (N-Propanol) plays a role in the production of diverse chemicals and pharmaceuticals.
Its linear propyl chain distinguishes it from isopropyl alcohol, influencing its chemical behavior.
N-propyl alcohol (N-Propanol) is involved in the synthesis of flavor and fragrance compounds.

As a propionic alcohol, it contributes to the creation of plasticizers for plastics.
N-propyl alcohol (N-Propanol) may find use in the fuel industry for specific applications, including fuel formulations.

Its volatility makes it useful in processes where controlled evaporation is desired.
In certain formulations, it can serve as a fuel additive, impacting combustion characteristics.
In chemical reactions, 1-Propanol may act as a reducing agent in certain processes.

N-propyl alcohol (N-Propanol) participates in esterification processes, contributing to the synthesis of esters.
N-propyl alcohol (N-Propanol) may be employed in the production of biodiesel or other fuel formulations.
N-propyl alcohol (N-Propanol) can play a role in the manufacturing of plastics, contributing to specific properties.

Its properties make it suitable for use in personal care products such as lotions and creams.
In certain applications, it may serve as a flame retardant additive.
N-propyl alcohol (N-Propanol) acts as a solvent for pharmaceutical formulations, aiding in drug delivery.

In the paint and coatings industry, 1-Propanol is used as a solvent to control viscosity.
N-propyl alcohol (N-Propanol) is utilized for cleaning surfaces in various industrial and commercial settings.
Its chemical structure contributes to the synthesis of diverse chemical derivatives used in various applications.



DESCRIPTION


N-propyl alcohol, also known as n-propanol or 1-propanol, is a primary alcohol with the molecular formula C3H8O.
N-propyl alcohol (N-Propanol) is an isomer of isopropyl alcohol (2-propanol) and ethanol (ethyl alcohol).
The term "n" in N-propyl alcohol indicates that the propyl group is linear, meaning the carbon atoms are arranged in a straight chain.

N-propyl alcohol (N-Propanol) is a colorless liquid with a characteristic alcoholic odor.
It is a primary alcohol with the chemical formula C3H8O, featuring a straight-chain propyl group.
N-propyl alcohol (N-Propanol) is miscible with water, making it a versatile solvent in various industries.

N-propyl alcohol exhibits good solvency, making it suitable for use in the formulation of coatings, inks, and adhesives.
With a molecular weight of approximately 60.10 g/mol, 1-propanol is relatively lightweight compared to other alcohols.
N-propyl alcohol (N-Propanol) is commonly used as a chemical intermediate in the synthesis of pharmaceuticals and other organic compounds.

As a cleaning agent, 1-propanol is effective in removing dirt, grease, and contaminants from surfaces.
In laboratories, N-propyl alcohol (N-Propanol) finds application as a solvent and reagent in various chemical reactions.
The odor of 1-propanol is distinctive, and proper ventilation is crucial when handling it in enclosed spaces.

Due to its flammable nature, precautions must be taken to avoid ignition sources and ensure safe storage.
N-propyl alcohol (N-Propanol) is used in the production of chemicals and pharmaceuticals, contributing to the synthesis of diverse products.

Its linear propyl chain distinguishes it from isopropyl alcohol, which has a branched propyl group.
N-propyl alcohol (N-Propanol) can be employed as a fuel additive or in the manufacturing of biodiesel.
In the pharmaceutical industry, it may serve as a solvent for the preparation of certain medications.
The volatility of n-propyl alcohol makes it useful in processes where controlled evaporation is desired.

As a propionic alcohol, it is involved in the creation of plasticizers and other chemical derivatives.
The chemical structure of 1-propanol includes a hydroxyl group attached to the first carbon atom in the propyl chain.

N-propyl alcohol (N-Propanol) has a boiling point of approximately 97.2 degrees Celsius under standard atmospheric pressure.
In certain chemical reactions, n-propyl alcohol may act as a reducing agent or participate in esterification processes.

N-propyl alcohol (N-Propanol) is classified as a primary alcohol, indicating that the hydroxyl group is attached to a primary carbon.
Its properties make it suitable for use in the formulation of personal care products, such as lotions and creams.

N-propyl alcohol (N-Propanol) is an important component in the synthesis of flavor and fragrance compounds.
In the paint and coatings industry, 1-propanol may be used as a solvent for achieving specific viscosity and drying characteristics.
Its physical and chemical properties contribute to its role in diverse applications, showcasing its versatility in various industrial processes.



PROPERTIES


Chemical Formula: C3H8O
Molecular Weight: Approximately 60.10 g/mol
Structure: CH3-CH2-CH2-OH
IUPAC Name: Propan-1-ol
Common Names: 1-Propanol, N-propyl alcohol, Propyl alcohol
Physical State: Colorless liquid
Odor: Characteristic alcoholic odor
Solubility in Water: Miscible
Boiling Point: Approximately 97.2 °C (207 °F)
Melting Point: −126 °C (−195 °F)
Density: 0.8038 g/cm³ at 20 °C
Flash Point: 26 °C (79 °F) - Flammable
Vapor Pressure: 9.2 mmHg at 20 °C
Refractive Index: 1.386
Autoignition Temperature: 365 °C (689 °F)
Viscosity: 2.46 mPa·s at 25 °C
Surface Tension: 23.7 mN/m at 25 °C
Heat of Combustion: 2,680 kJ/mol
Heat of Vaporization: 40.79 kJ/mol
Critical Temperature: 235 °C
Critical Pressure: 5.25 MPa
Critical Volume: 336 cm³/mol
Evaporation Rate: 3.3 (n-butyl acetate = 1)
Dielectric Constant (ε): 20.7
pH: Neutral



FIRST AID


Inhalation:

Move to Fresh Air:
If inhaled, immediately move the person to fresh air to avoid further exposure.

Provide Oxygen:
If breathing is difficult, provide oxygen if available, and seek medical attention.

Artificial Respiration:
If breathing has stopped, perform artificial respiration and seek emergency medical assistance.

Medical Attention:
Seek immediate medical attention, especially if symptoms persist or worsen.


Skin Contact:

Remove Contaminated Clothing:
Remove any contaminated clothing promptly.

Wash Skin:
Wash the affected skin area with plenty of water and mild soap for at least 15 minutes.

Seek Medical Attention:
If irritation or redness persists, seek medical attention.


Eye Contact:

Flush Eyes:
Immediately flush the eyes with gently flowing water for at least 15 minutes, lifting the upper and lower eyelids occasionally.

Seek Medical Attention:
Seek immediate medical attention if irritation or other symptoms persist.


Ingestion:

Do Not Induce Vomiting:
Do not induce vomiting unless instructed by medical personnel.

Rinse Mouth:
Rinse the mouth with water if the person is conscious.

Seek Medical Attention:
Seek immediate medical attention.
Provide medical personnel with information about the ingested substance.


First Aid for First Responders:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including gloves and protective clothing, when responding to spills or accidents involving 1-Propanol.

Ventilation:
Ensure proper ventilation in the affected area to minimize exposure.

Emergency Procedures:
Follow established emergency procedures and protocols.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles, and protective clothing, to minimize skin and eye contact.
Use respiratory protection, such as a mask or respirator, if handling the substance in an area with inadequate ventilation.

Ventilation:
Ensure adequate ventilation in the handling area to prevent the accumulation of vapors.
Use local exhaust ventilation or mechanical ventilation systems if working with larger quantities or in confined spaces.

Avoid Contact:
Avoid skin and eye contact.
In case of contact, follow first aid measures as outlined in the safety data sheet (SDS).

Preventive Measures:
Implement good industrial hygiene practices, including regular handwashing and avoiding unnecessary exposure.
Do not eat, drink, or smoke while handling the substance.

Static Electricity:
Take precautions to prevent the build-up of static electricity, which could lead to fire hazards. Ground equipment properly.

Spill and Leak Procedures:
Implement spill control measures to contain and clean up spills promptly.
Use absorbent materials to soak up spills, and dispose of waste according to local regulations.


Storage:

Container Selection:
Store 1-Propanol in containers made of materials compatible with the substance (e.g., high-density polyethylene, stainless steel).
Ensure containers are tightly sealed to prevent evaporation and contamination.

Storage Area:
Store in a cool, well-ventilated area away from direct sunlight, heat sources, and incompatible materials.
Keep away from ignition sources, open flames, and hot surfaces.

Temperature Control:
Maintain storage temperatures within recommended ranges to prevent potential hazards associated with temperature extremes.

Segregation:
Segregate from incompatible substances to prevent reactions or contamination.

Fire Prevention:
Implement fire prevention measures in the storage area, including the availability of fire extinguishing equipment.
Store away from oxidizing agents and strong acids.

Labeling:
Clearly label storage containers with the product name, hazard information, and appropriate safety symbols.

Handling Cautions:
Exercise caution during handling and storage to prevent spills, leaks, or accidents.


Emergency Response:

Emergency Contacts:
Ensure that emergency contact information is readily available.
Train personnel on emergency response procedures.

Training:
Provide training to personnel involved in handling, storage, and emergency response to ensure proper awareness and action in case of incidents.
n-Propylamine
PA;MNPA;AMINE C3;n-C3H7NH2;Propylamin;Propanamine;PROPYLAMINE;PROPANEAMINE;1-Aminopropan;1-Propylamine CAS No.107-10-8
N-Propylbromide
N-VINYL PYRROLIDONE, N° CAS : 88-12-0, 1-vinyl-2-pyrrolidone , CAS : 88-12-0. Synonymes : 1-vinyl-2-pyrrolidone;Vinylpyrrolidone;Éthényl-1 pyrrolidone-2;N-Vinyl pyrrolidinone-2;Vinylbutyrolactam;1-Ethenylpyrrolidin-2-one;N-Vinyl-2-pyrrolidinone;1-Ethenyl-2-pyrrolidinone;1-Vinyl-2-pyrrolidinone;1-vinyl-tetrahydropyrrol-2-one;1-vinylpyrrolidinone;2-Pyrrolidinone, 1-ethenyl-;2-Pyrrolidinone, 1-vinyl-;N-vinyl-2-pyrrolidone;N-vinylbutyrolactam;N-Vinylpyrrolidinone;N-vinylpyrrolidone;NSC 1022;NVP;povidone monomer;Nom INCI : N-VINYL PYRROLIDONE. Nom chimique : 2-Pyrrolidinone, 1-ethenyl-,1-Vinylpyrrolidinone,1-Vinylpyrrolidone. V-PYROL, Vinylbutyrolactam, Vinylpyrrolidone. N° EINECS/ELINCS : 201-800-4
n-tert. Butylacrylamide
Nonylphenol ethoxylate with 9 EO ; About 100 % ; Liquid ; Cloud point : 52 – 54 (1) ; HLB : About 13
N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS)
DESCRIPTION:
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a commonly used aftereffect accelerator.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is very safe at operating temperature, has good scorch resistance, and has high constant elongation strength, which can improve the use of synthetic glue proportion.


CAS Number: 95-31-8
European Community (EC) Number: 202-409-1
Molecular Formula: C11H14N2S2



SYNONYMS OF N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS):
Benzothiazolesulfenamide, n-(1,1-dimethylethyl)- Benzothiazolyl-2-tert-butylsulfenamide n-(1,1-Dimethylethyl)-2-benzothiazolesulfenamide n-Tert,-butyl-2-benzothiazolsulfenamide,N-tert-Butyl-2-benzothiazolesulfenamide,95-31-8,Santocure NS,Nocceler NS,Vulkacit NZ,Accel BNS,Pennac Tbbs,2-(TERT-BUTYLAMINOTHIO)BENZOTHIAZOLE,Vanax NS,2-Benzothiazolesulfenamide, N-(1,1-dimethylethyl)-,S-(Benzo[d]thiazol-2-yl)-N-(tert-butyl)thiohydroxylamine,2 Benzothiazolesulfenamide, N-tert-butyl-,Benzothiazolyl-2-tert-butylsulfenamide,N-tert-Butyl-2-benzothiazylsulfenamide,NSC 84176,Santocure NS vulcanization accelerator,N-(1,3-benzothiazol-2-ylsulfanyl)-2-methylpropan-2-amine,N-tert-Butyl-2-benzothiazolyl sulfenamide,W468IFJ99C,DTXSID7026572,Benzothiazolesulfenamide, N-(1,1-dimethylethyl)-,NSC-84176,NS-P; NSC 84176; NSG; Nocceler NS-P; Perkacit TBBS,S-(Benzo[d]thiazol-2-yl)-N-(tert-butyl)-thiohydroxylamine,N-tert-Butylbenzothiazole-2-sulphenamide,Akrochem BBTS,NTBBTS,TBBS,N-t-Butylbenzothiazylsulfenamide,HSDB 5288,C11H14N2S2,EINECS 202-409-1,N-t-Butyl-2-benzothiazolesulfenamide,S-(benzo[d]thiazol-2-yl)-N-tert-butylthiohydroxylamine,BRN 0158370,UNII-W468IFJ99C,N-(1,1-Dimethylethyl)benzothiazolesulfenamide,Santocure TBBS,Perkacit TBBS,Delac NS,Vanax TBSI,Vulkacit NZ/EG,N-tert-Butyl-2-benzothiazosulfenamide,BBTS,SULFENAMIDE TBBS,RHENOGRAN TBBS 80,EC 202-409-1,2-[(tert-Butylamino)sulfanyl]-1,3-benzothiazole,SCHEMBL80374,DTXCID506572,CHEMBL3182037,Butyl 2-benzothiazole sulfenamide,IUJLOAKJZQBENM-UHFFFAOYSA-N,HMS1675L02,NSC84176,Tox21_200895,MFCD00022873,n-t-butyl-2-benzothiazole sulfenamide,AKOS000520589,N-t-Butyl-2-benzothiazole-sulfenamide,N-tert-Butyl-2-benzothiazolesulfenamid,N-t-Butyl-2-benzothioazole sulfenamide,CAS-95-31-8,n-tert-butyl-2-benzothiazyl sulfenamide,N-t-Butyl-O-benzothiazole-2-sulfenamide,n-tert-butyl-2-benzothiazole sulfenamide,N-tert-Butyl-2-benzothiazolesulphenamide,N-tert-Butyl-2-benzothiazolylsulfenamide,NCGC00248869-01,NCGC00258449-01,WLN: T56 BN DSJ CSMX1&1&1,AS-15571,N-tert-butyl-2-(4-piperidyloxy)acetamide,2-Benzothiazolesulfenamide,1-dimethylethyl)-,EU-0002407,FT-0631485,D70664,BUTYL-2-BENZOTHIAZOLE SULFENAMIDE, N-TERT-,N-TERT- BUTYL-2-BENZOTHIAZOLE SULFENAMIDE,SR-01000408154,2-(TERT-BUTYLAMINOTHIO)BENZOTHIAZOLE [HSDB],2-[(tert-Butylamino)sulfanyl]-1,3-benzothiazole #,SR-01000408154-1,W-100166,Q27292283,(13-BENZOTHIAZOL-2-YLSULFANYL)(TERT-BUTYL)AMINE,N-(1,3-benzothiazol-2-ylthio)-2-methylpropan-2-amine, n-tert-butyl-2-benzothiazolesulphenamide; accelerator ns; 2-(tert-butylaminothio)benzothiazole; n-tertiarybutyl-2-benzothiazole sulfennamide; tbbs; 2-[(tert-butylamino)sulfanyl]-1,3-benzothiazole; 2-benzothiazolesulfenamide, n-tert-butyl-; accel bns; accelbns; accelerator(ns); acceleratorns; akrochem bbts; bbts; benzothiazolesulfenamide, n-(1,1-dimethylethyl)-; benzothiazolyl-2-tert-butylsulfenamide; butyl 2-benzothiazole sulfenamide; butylbenzothiazole sulfenamide; conacns,(dupont); delac ns; n-(1,1-dimethylethyl)-2-benzothiazolesulfenamid; n-(1,1-dimethylethyl)-2-benzothiazolesulfenamide; n-(1,1-dimethylethyl)-benzothiazolesulfenamid; n-(1,1-dimethylethyl)benzothiazolesulfenamide; n-t-butyl-2-benzothioazole sulfenamide; N-(1,3-benzothiazol-2-ylsulfanyl)-2-methylpropan-2-amine; NS; Acelerator NS; Rubber Accelerator TBBS; Rubber Accelerator NS; ACCELERATOR TBBS(NS); ACCELERATOR TBBS, 2-(tert-Butylaminothio)benzothiazole, 2-[[(1,1-Dimethylethyl)amino]thio]benzothiazole, Antioxidant NS, BBTS, Benzothiazolyl-2-tert-butylsulfenamide, N-(1,1-Dimethylethyl)-2-benzothiazolesulfenamide, n-tert-Butyl-2-benzothaiazole sulfonamide, N-tert-Butyl-2-benzothiazolylsulfenamide, N-tert-Butyl-2-benzothiazolylsulphenamide, N-tert-Butylbenzothiazolesulfenamide, TBBS





USES OF N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS):
N-Tert-butylbenzothiazole-2-sulphenamide is used as a vulcanization accelerator in the manufacture of tires, belts and other rubber products.
N-Tert-butylbenzothiazole-2-sulphenamide is a natural rubber, butadiene rubber, isoprene rubber, styrene butadiene rubber and reclaimed rubber aftereffect accelerator, especially suitable for carbon black rubber with strong alkaline content.

N-Tert-butylbenzothiazole-2-sulphenamide is safe at operating temperature, strong scorch resistance, fast vulcanization speed, high constant elongation strength, and can improve the use ratio of synthetic rubber.
Low toxicity and high efficiency, it is an ideal substitute for NOBS, has excellent comprehensive performance, and is called a standard accelerator. Widely used in the production of radial tires.

N-Tert-butylbenzothiazole-2-sulphenamide can be used with aldehydes, guanidines, and thiuram accelerators, and when combined with anti-scorch agent PVI, it forms a good vulcanization system.
N-Tert-butylbenzothiazole-2-sulphenamide is Mainly used in the manufacture of tires, rubber shoes, rubber hoses, tapes, and cables.



APPLICATIONS OF N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS):
N-Tert-butylbenzothiazole-2-sulphenamide is an amine organic substance, which can increase the amount of filler carbon black.
N-Tert-butylbenzothiazole-2-sulphenamide is called "standard accelerator" and is currently the dominant type of sulfamide vulcanization accelerator
One of the varieties is mainly used in natural rubber, cis-butadiene rubber, styrene butadiene rubber, isoprene rubber.
PRODUCTION METHOD OF N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS):

N-Tert-butylbenzothiazole-2-sulphenamide is obtained by the reaction of the sodium salt of 2-thiobenzothiazole (accelerator M) with tert-butylamine.
Slowly add 0.75mol of tert-butylamine to 0.5mol of sodium salt solution of 13% accelerator M, add 0.36mol of 25% sulfuric acid solution after half an hour, and react at 45-50 ℃ for 0.5h.
0.6mol 15% sodium hypochlorite was added within 2 hours.
After the reaction, it is cooled, filtered, washed, and dried below 50°C to obtain the product.



SAFETY INFORMATION ABOUT N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product







CHEMICAL AND PHYSICAL PROPERTIES OF N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS):
Molecular Weight
238.4 g/mol
XLogP3
3.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
238.05984080 g/mol
Monoisotopic Mass
238.05984080 g/mol
Topological Polar Surface Area
78.5Ų
Heavy Atom Count
15
Formal Charge
0
Complexity
215
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Molecular Formula, C11H14N2S2

Molar Mass, 238.37
Density, 1,29 g/cm3
Melting Point, 105°C
Boling Point, 344.1±25.0 °C(Predicted)
Flash Point, 165°C
Vapor Presure, 6.72E-05mmHg at 25°C
BRN, 158370
pKa, 1.25±0.70(Predicted)
Storage Condition, Keep in dark place,Sealed in dry,Room Temperature
Refractive Index, 1.5500 (estimate)
Physical and Chemical Properties, Chemical properties light yellow brown powder. Soluble in benzene, dichloromethane, carbon tetrachloride, ethyl acetate, acetone, ethanol, soluble in gasoline, insoluble in water.


Melting point, 105°C
Boiling point, 344.1±25.0 °C(Predicted)
Density, 1,29 g/cm3
vapor pressure, 0Pa at 25℃
refractive index, 1.5500 (estimate)
Flash point, 165°C
storage temp., Keep in dark place,Sealed in dry,Room Temperature
pka, 1.25±0.70(Predicted)
Water Solubility, 1.74mg/L at 20℃
BRN, 158370
LogP, 3.36 at 25℃
CAS RN.:, 95-31-8
EINECS:, 202-409-1
Molecular Weight:, 238.3723
Molecular Formula:, C11H14N2S2
Density:, 1.22g/cm3
Melting Point(℃):, 105℃
Boiling Point(℃):, 344.1°C at 760 mmHg
Flash Point(℃):, 161.9°C
refractive_index:, 1.642
























N-TERT-BUTYLBENZOTHIAZOLE-2- SULPHENAMIDE (BBTS)

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is a pale yellow to tan crystalline powder widely used as an accelerator in the rubber industry.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is known for its role in promoting the vulcanization process of rubber, enhancing its strength and durability.

Chemical Formula: C11H14N2S2
CAS Number: 95-31-8
EC Number: 202-409-1
Molecular Weight: Approximately 238.37 g/mol

Synonyms: BBTS, TBBTS, N-tert-Butyl-2-benzothiazolesulfenamide, N-(1,1-dimethylethyl)-2-benzothiazolesulfenamide, N-(1,1-dimethylethyl)-2-benzothiazolylsulfenamide, N-(1,1-dimethylethyl)benzothiazole-2-sulfenamide, N-(tert-butyl)-2-benzothiazolesulfenamide, 2-(tert-butylaminothio)benzothiazole, 2-Benzothiazolyl-N-tert-butylsulfenamide, 2-Benzothiazolyl-N-tert-butylsulfenimide, 2-Benzothiazolyl-N-tert-butylsulphenamide, Accel TBS, Accelerator BBTS, Accelerator TBS, Akrochem TBBS, Akrosperse TBBS, Albemarle TBBS, Altax TBBS, Altaax TBBS, Aulamine TBBS, Baysafe TBBS, Benzothiazyl-2-tert-butylsulfenamide, Captax TBBS, CBS-75, CBS-LG, CBS-LG (accelerator), CBS-TBBS, CBTS-TBBS, Conacure TBBS, Cusal TBBS, Cyclohexyl benzothiazole sulfenamide, Cyclotrac, Cyclotrac 4010NA, Cyrez TBBS, Delac NS/TBBS, Delac TBBS, Delac TBBS (accelerator), Ekagom TBBS, Flexzone TBBS, Flochex TBBS, Hekmaster TBBS, Kosmos TBBS, MBTS/TBBS, N-Butyl-2-benzothiazolesulfenamide, N-Cyclohexyl-2-benzothiazolesulfenamide, N-TBBTS, N-TBBTS (accelerator), Naugex TBBS, Naugex TBBS (accelerator), Nocceler TBBS, Nocceler TBBS (accelerator), Nocceler TBBS-75, NSC 83742, Pennac TBBS, Perkacit TBBS, Perkacit TBBS/C, Rhenogran TBBS, Royal TBBS, Sirantox TBBS, Sulfenax TBBS, Sulfenax TBBS (accelerator), Sulfenax TBBS (vulcanization accelerator), TBBS, TBBS (accelerator), TBBS (vulcanization accelerator), TBBS-CZ, TBBS-CZ (accelerator), TBBS/MBTS, TBBS/MBTS (accelerator), Thiozone TBBS, TMTD/TBBS, Vulkacit TBBS, Vulkacit TBBS (accelerator), Vulkacit TBBS-75, Vulkazon TBBS



APPLICATIONS


N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is extensively used as an accelerator in the vulcanization process of rubber, particularly in the production of tires.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) accelerates the cross-linking of rubber polymers, enhancing the mechanical strength and durability of tire treads.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is crucial in the manufacture of conveyor belts, where it improves abrasion resistance and longevity.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) accelerates the curing of rubber used in seals and gaskets, ensuring effective sealing in automotive applications.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the production of rubber hoses and tubing, providing flexibility and resistance to various fluids.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the elasticity and wear resistance of rubber components used in footwear, such as soles and heels.

In the construction industry, BBTS contributes to the production of weather-resistant rubber materials for roofing and sealing applications.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in industrial rubber rollers, ensuring smooth operation in printing and manufacturing machinery.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) plays a role in the formulation of rubber diaphragms and membranes for use in pumps and valves.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the production of rubberized fabrics used in protective clothing and industrial applications.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the manufacture of vibration-damping rubber mounts and bushings for automotive and machinery applications.
The chemical enhances the performance of rubber components in agricultural machinery, providing durability and reliability.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is utilized in the production of rubber seals and gaskets for mechanical and electrical equipment.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is an essential component in the formulation of rubber coatings and linings, offering corrosion resistance in industrial settings.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) aids in improving the heat aging properties of rubber, making it suitable for high-temperature applications.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS)'s compatibility with various rubber polymers makes it versatile in formulating customized rubber compounds.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of rubber products for the mining industry, where durability and resistance to wear are critical.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the manufacturing of rubber parts for marine applications, such as seals and gaskets for marine vessels.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the electrical insulation properties of rubber, making it essential in the production of cables and electrical components.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the production of rubber diaphragms and valves used in medical and pharmaceutical applications.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is crucial in the formulation of industrial rubber belts and hoses for conveying materials and fluids.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of rubber components for sports equipment, ensuring durability and performance.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) plays a role in the formulation of rubber compounds for aerospace applications, including seals and insulation materials.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS)'s role extends to the production of rubberized surfaces for playgrounds and recreational facilities.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is indispensable in industries where rubber products require superior mechanical properties, durability, and reliability.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of automotive rubber parts such as engine mounts, bushings, and vibration isolators.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the resilience and damping properties of rubber components in automotive suspension systems.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is crucial in the formulation of rubber seals and gaskets for HVAC (heating, ventilation, and air conditioning) systems.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the production of rubber conveyor belts used in mining and bulk material handling industries.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the manufacture of industrial rubber seals and o-rings for fluid and gas sealing applications.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of rubber expansion joints and couplings for piping systems, ensuring flexibility and leak resistance.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the performance of rubber belting used in agricultural equipment for conveying crops and materials.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is utilized in the formulation of rubber components for railroad infrastructure, including rail pads and crossings.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) plays a role in the production of rubber flooring and mats for commercial and industrial applications.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the manufacture of rubber dampers and shock absorbers for machinery and equipment.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the production of rubber components for the aerospace industry, including seals and gaskets for aircraft.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the formulation of specialty rubber compounds for military applications, ensuring reliability in extreme conditions.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the performance of rubber gloves used in medical and laboratory settings, providing flexibility and durability.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the production of rubber components for recreational vehicles (RVs), ensuring comfort and reliability during travel.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) plays a role in the formulation of rubber seals and gaskets for marine applications, including boats and offshore structures.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of rubberized rollers and wheels for material handling equipment and industrial machinery.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the manufacture of rubber seals and gaskets for hydraulic and pneumatic systems, ensuring efficient operation.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the durability and resistance of rubber components used in power transmission belts and automotive timing belts.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the production of rubberized surfaces for playgrounds, ensuring safety and comfort for children.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the formulation of rubber components for sporting goods such as balls, grips, and athletic footwear.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) plays a role in the production of rubber components for consumer electronics, providing shock absorption and insulation.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is employed in the manufacture of rubber parts for household appliances, ensuring reliability and longevity.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) the performance of rubber seals and gaskets used in food processing and pharmaceutical industries, ensuring hygiene and safety.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of rubber components for renewable energy applications, including solar panel mounting systems.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the formulation of rubber compounds for environmental sealing and containment systems, ensuring protection against leaks and contamination.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS)'s versatility extends to the production of rubber seals and gaskets used in mechanical and electrical equipment.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is known for its stability under normal storage conditions, maintaining its effectiveness over extended periods.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) enhances the heat aging properties of rubber, making it suitable for applications requiring resistance to high temperatures.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is used in the production of rubber diaphragms and membranes, crucial in industrial pumps and valves for their sealing properties.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS)'s compatibility with various rubber polymers makes it a preferred choice in formulating customized rubber compounds.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) aids in improving the performance of rubber components used in agricultural machinery and equipment.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) contributes to the production of rubberized fabrics used in protective clothing and industrial applications.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is integral in the formulation of rubber products for the mining industry, ensuring durability in demanding operational environments.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS)'s role in enhancing the electrical insulation properties of rubber makes it essential in manufacturing cables and wires.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is indispensable in modern industries where rubber products require superior mechanical properties and performance characteristics.



DESCRIPTION


N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is a pale yellow to tan crystalline powder widely used as an accelerator in the rubber industry.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is known for its role in promoting the vulcanization process of rubber, enhancing its strength and durability.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) belongs to the class of sulfenamide accelerators, which are crucial in achieving rapid and efficient cross-linking of rubber polymers.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) accelerates the formation of cross-links between rubber molecules, thereby improving the mechanical properties of rubber products.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is characterized by its ability to reduce curing time and optimize the production process of rubber goods.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is effective in enhancing the tensile strength, tear resistance, and abrasion resistance of vulcanized rubber.
The chemical structure of BBTS includes a benzothiazole ring and a tert-butyl group attached to the sulfur atom, imparting specific properties to the accelerator.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is sparingly soluble in water but dissolves readily in organic solvents such as acetone and benzene.
In rubber manufacturing, BBTS is used in the production of tires, conveyor belts, seals, gaskets, and various industrial rubber goods.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) plays a crucial role in the automotive industry, ensuring the performance and longevity of rubber components in vehicles.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) accelerates the curing of rubber compounds used in construction materials, contributing to their weather resistance and durability.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS)'s application extends to the production of footwear, where it enhances the elasticity and wear resistance of rubber soles and heels.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is utilized in the formulation of rubber coatings and linings for its ability to withstand harsh environmental conditions.

N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is an essential ingredient in the manufacture of rubber hoses and tubing, providing flexibility and resilience in fluid handling applications.
N-Tert-butylbenzothiazole-2- sulphenamide (BBTS) is valued for its contribution to the production of industrial rubber rollers, ensuring smooth operation and longevity in machinery.



PROPERTIES


Physical Properties:

Appearance: Pale yellow to tan crystalline powder
Odor: Slight characteristic odor
Melting Point: Approximately 105-108°C
Boiling Point: Decomposes before boiling
Density: 1.26 g/cm³ (at 20°C)
Solubility in Water: Sparingly soluble (negligible)
Solubility in Organic Solvents: Soluble in acetone, benzene, ethanol, and other organic solvents
Flash Point: Not applicable (non-flammable)
Vapor Pressure: Low


Chemical Properties:

Chemical Formula: C11H14N2S2
Molecular Weight: Approximately 238.37 g/mol
CAS Number: 95-31-8
EC Number: 202-409-1



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
Provide oxygen if breathing is difficult.


Skin Contact:

Remove contaminated clothing and shoes immediately.
Wash affected skin thoroughly with soap and water for at least 15 minutes.
Seek medical attention if irritation or rash develops.


Eye Contact:

Rinse eyes gently with water for at least 15 minutes, holding eyelids open to ensure thorough flushing.
Remove contact lenses if present and easily removable.
Seek immediate medical attention if irritation, redness, or pain persists.


Ingestion:

Do not induce vomiting unless directed by medical personnel.
Rinse mouth with water if the person is conscious and able to swallow.
Seek immediate medical attention. Provide the medical personnel with information about the chemical ingested.


General First Aid:

Personal Protection:
Wear appropriate personal protective equipment (PPE) during first aid response (gloves, safety goggles).

Medical Attention:
Always seek medical attention after any exposure, even if symptoms are not immediately apparent.

Symptom Management:
Treat symptoms based on the individual's condition and symptoms observed.

Emergency Contact:
Have the product container or Safety Data Sheet (SDS) available for medical personnel, providing necessary information about the chemical and its potential health effects.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing.
Use respiratory protection (e.g., NIOSH-approved respirator) if ventilation is inadequate and exposure levels are high.

Ventilation:
Use in a well-ventilated area to minimize exposure to airborne particles or vapors.
Implement local exhaust ventilation at points of generation to capture and remove BBTS dust or fumes.

Avoidance of Contact:
Avoid skin contact and inhalation of dust or vapors.
Prevent ingestion by not eating, drinking, or smoking in areas where BBTS is handled.

Handling Practices:
Handle BBTS with care to prevent spills and minimize dust generation.
Use equipment and tools that are grounded to prevent static electricity buildup.

Storage Compatibility:
Store BBTS in a cool, dry, well-ventilated area away from direct sunlight and sources of heat.
Keep containers tightly closed when not in use to prevent contamination and moisture absorption.

Separation from Incompatible Materials:
Store BBTS away from strong oxidizing agents, acids, and bases to prevent hazardous reactions.

Handling Containers:
Use appropriate containers made of compatible materials (e.g., stainless steel, polyethylene) to store and transport BBTS.
Ensure containers are labeled with the correct chemical name and hazard information.

Spill and Leak Procedures:
Clean up spills immediately using absorbent materials such as vermiculite or sand.
Avoid creating dust during cleanup. Collect spilled material in a suitable container for disposal according to local regulations.

Emergency Procedures:
Have spill control measures and personal protective equipment readily available.
In case of a large spill or release, evacuate the area and contact emergency response personnel.


Storage:

Storage Conditions:
Store BBTS in a tightly closed container in a cool, dry, and well-ventilated area.
Maintain storage temperature between 15°C to 30°C (59°F to 86°F) to prevent degradation.

Protection from Physical Damage:
Protect containers from physical damage and exposure to moisture.
Ensure stored materials are not subject to temperature extremes or direct sunlight.

Segregation and Compatibility:
Store BBTS separately from food, feedstuffs, and other chemicals to avoid contamination.
Segregate from incompatible materials to prevent potential reactions.

Fire Protection:
BBTS is non-flammable and not combustible under normal storage conditions.
However, avoid exposure to high temperatures and sources of ignition.

Handling of Empty Containers:
Empty containers may retain residues of BBTS. Handle empty containers with care and follow disposal guidelines.

Monitoring and Maintenance:
Regularly inspect storage areas and containers for leaks, damage, or signs of deterioration.
Implement proper inventory control and rotation to ensure older stock is used first.

Regulatory Compliance:
Comply with local regulations and guidelines for the storage, handling, and disposal of BBTS.
Maintain accurate records of storage and handling activities for regulatory reporting purposes.
N-TERT-BUTYLBENZOTHIAZOLE-2-SULPHENAMIDE (BBTS)

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a high-performance rubber accelerator commonly used in the rubber industry to improve the vulcanization process.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is recognized for its ability to enhance the physical properties of rubber products, including elasticity, tensile strength, and durability.
The chemical formula for N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is C11H14N2S2, and it is widely used in various industrial applications due to its effective properties.

CAS Number: 95-31-8
EC Number: 202-409-1

Synonyms: N-Tert-butyl-2-benzothiazolesulfenamide, TBBS, BBTS, N-Tert-butylbenzothiazole sulfenamide, Santocure TBBS, Accelerator TBBS, 2-Benzothiazolesulfenamide, N-Tert-butyl-, TBBS Accelerator, Vulcanization accelerator TBBS, N-Tert-butylbenzothiazol-2-ylsulfenamide



APPLICATIONS


N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is extensively used as a primary accelerator in the vulcanization of natural and synthetic rubbers.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is particularly favored in the production of tires, offering excellent scorch safety and fast curing times.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the manufacture of industrial rubber products such as hoses, belts, and seals, improving their durability and resilience.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is widely used in the production of automotive rubber components, including gaskets, weatherstrips, and vibration dampening products, ensuring optimal performance.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the formulation of rubber compounds for footwear, providing enhanced flexibility, wear resistance, and comfort.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is essential in the rubber industry for the production of conveyor belts, improving their tensile strength and longevity.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the creation of rubberized fabrics, offering improved elasticity and durability for industrial and consumer applications.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a key component in the manufacture of rubber-based adhesives and sealants, contributing to their strong bonding capabilities and long-term performance.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the formulation of specialty rubber compounds used in high-performance applications, ensuring consistent quality and durability.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is applied in the production of rubber products for the construction industry, such as rubber mats and protective coatings, enhancing their resistance to environmental factors.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the production of rubber sheets and films, improving their flexibility, tear resistance, and tensile strength.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the manufacturing of rubber insulation materials, providing enhanced thermal stability and resistance to aging.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is found in the production of rubber seals and O-rings, ensuring their durability and resistance to harsh environmental conditions.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the automotive industry for the production of high-performance rubber hoses, contributing to their heat resistance and long service life.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the formulation of rubber compounds for anti-vibration products, offering excellent shock absorption and resilience.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the production of specialty rubber compounds for the aerospace industry, ensuring high performance under extreme conditions.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the manufacturing of rubber components for marine applications, providing resistance to saltwater corrosion and UV exposure.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is found in the production of rubber grommets and bushings, enhancing their flexibility, wear resistance, and long-term performance.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the creation of rubber linings for industrial equipment, offering enhanced resistance to abrasion and chemical exposure.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the production of rubber components for mining applications, providing superior durability, impact resistance, and longevity.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the formulation of rubber compounds for high-pressure hydraulic seals, ensuring their long-term stability and performance under demanding conditions.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the production of rubber profiles for construction joints, providing enhanced sealing properties and durability.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the manufacturing of rubber components for railway applications, contributing to their wear resistance and durability under heavy loads.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the production of rubber components for oil and gas exploration, ensuring their performance and resistance to high-pressure environments.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is found in the formulation of rubber compounds for industrial rollers, offering improved wear resistance, load-bearing capacity, and longevity.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the creation of specialty rubber compounds for high-temperature applications, ensuring their stability and performance in extreme conditions.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a key component in the production of rubber components for heavy machinery, enhancing their durability and resistance to harsh environments.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the production of rubber components for industrial valves, offering improved sealing properties, chemical resistance, and long-term reliability.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the formulation of rubber compounds for electrical insulation, ensuring their stability, safety, and long-term performance.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the production of rubber belts and drive systems, enhancing their flexibility, load-bearing capacity, and service life.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is found in the manufacturing of rubber components for the food and beverage industry, ensuring compliance with safety standards and long-term durability.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the formulation of rubber compounds for medical applications, offering biocompatibility, sterilizability, and performance under stringent conditions.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is employed in the creation of rubber linings for storage tanks, providing resistance to chemical corrosion and long-term durability.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is utilized in the production of rubber components for agricultural machinery, offering durability, resistance to wear, and performance in demanding conditions.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is used in the formulation of rubber compounds for high-performance automotive parts, providing enhanced heat resistance, wear resistance, and overall performance.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a key ingredient in the production of rubber components for the electronics industry, ensuring their stability, durability, and long-term performance.



DESCRIPTION


N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a high-performance rubber accelerator commonly used in the rubber industry to improve the vulcanization process.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is recognized for its ability to enhance the physical properties of rubber products, including elasticity, tensile strength, and durability.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a versatile chemical compound used in various rubber applications.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) provides excellent scorch safety, allowing for extended processing times without compromising the quality of the final product.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is essential in the production of high-performance rubber products, contributing to their strength, resilience, and resistance to wear.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is widely used in the automotive industry, where it enhances the performance and durability of rubber components.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is also employed in the manufacturing of industrial rubber products, including hoses, seals, and gaskets, ensuring their long-term reliability and performance.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a critical accelerator in the vulcanization process, providing optimal curing and improving the overall quality of rubber compounds.

N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is recognized for its stability, effectiveness, and versatility in a wide range of rubber applications, from automotive components to industrial products.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is essential in the formulation of specialty rubber compounds, providing consistent performance and long-term reliability.
N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is a key ingredient in the production of rubber materials used in demanding environments, ensuring their resistance to extreme conditions and prolonged use.



PROPERTIES


Chemical Formula: C11H14N2S2
Common Name: N-Tert-butylbenzothiazole-2-sulphenamide (BBTS)
Molecular Structure:
Appearance: Pale yellow powder
Density: 1.27 g/cm³
Melting Point: 104-109°C
Solubility: Insoluble in water; soluble in benzene, acetone, and chloroform
Flash Point: 230°C
Reactivity: Stable under normal conditions; decomposes at high temperatures
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store below 25°C in a dry, well-ventilated area
Vapor Pressure: Negligible at room temperature



FIRST AID


Inhalation:
If N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust or vapors.
Do not eat, drink, or smoke while handling N-Tert-butylbenzothiazole-2-sulphenamide (BBTS).
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Avoid generating dust. Sweep up and collect the material for disposal in a sealed container.

Storage:
Store N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) in a cool, dry, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust or aerosols.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust or vapors may be present.


Storage:

Temperature:
Store N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) away from incompatible materials, including strong acids, bases, and oxidizing agents.

Handling Equipment:
Use dedicated equipment for handling N-Tert-butylbenzothiazole-2-sulphenamide (BBTS) to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
N-VINYL PYRROLIDONE
O-AMINOPHENOL, N° CAS : 95-55-6, Nom INCI : O-AMINOPHENOL, Nom chimique : 2-Aminophenol (CI 76520), N° EINECS/ELINCS : 202-431-1, Agent colorant pour cheveux : Colore les cheveux
NYNAS T 110
DESCRIPTION:
NYNAS T 110 is a high viscosity hydrotreated naphthenic base oil with excellent solvent power and very good low temperature properties.
NYNAS T 110 is used as a base oil in industrial and metalworking fluid formulations
In lubricating greases, the excellent solvent power of NYNAS T 110 positively affects production parameters, such as cooking temperature and soap consumption



USES OF NYNAS T 110:
The very good low temperature properties of NYNAS T 110 confer very good low temperature properties to the grease
NYNAS T 110 can be used in the production of lubricating greases, both in the cooking and cooling stage.
The oil can be used as well in drawing fluids, stamping fluids, extrusion fluids, steel rolling fluids, treating fluids, and cylinder oils.


In lubricating greases the excellent solvent power of NYNAS T 110 positively affects production parameters, such as cooking temperature, soap consumption, and response to oil dilution and some of the grease's end properties such as its structure and smoothness and the compatibility with elastomers.

Moreover, the very good low temperature properties of NYNAS T 110 confer very good low temperature properties to the grease.
NYNAS T 110 is a hydrotreated naphthenic base oil, classified as an API Group V base oil.

NYNAS T 110 US STANDARD is used as a base oil in industrial and metalworking fluid formulations.
In lubricating greases, the excellent solvent power of NYNAS T 110 US STANDARD positively affects production parameters, such as cooking temperature and soap consumption.

The very good low temperature properties of NYNAS T 110 US STANDARD confer very good low temperature properties to the grease.
NYNAS T 110 can be used in the production of lubricating greases, both in the cooking and cooling stage.


The oil can be used as well in drawing fluids, stamping fluids, extrusion fluids, steel rolling fluids, treating fluids, and cylinder oils.
In lubricating greases the excellent solvent power of NYNAS T 110 positively affects production parameters, such as cooking temperature, soap consumption, and response to oil dilution and some of the grease's end properties such as its structure and smoothness and the compatibility with elastomers.

Moreover, the very good low temperature properties of NYNAS T 110 confer very good low temperature properties to the grease.
NYNAS T 110 is a hydrotreated naphthenic base oil, classified as an API Group V base oil.


NYNAS T 110 NAPHTHENICS BASE OILS FOR INDUSTRIAL LUBRICANTS:
NYNAS T 110 naphthenic base oils are used as base fluids in the formulation of many types of industrial lubricants, alone or in blends with other base fluids

The solvency matches the requirements elastomeric materials used in seals and gaskets, improving the seal compatibility, which is of great importance in many lubricant applications, such as hydraulic fluids and gear oils
NYNAS T 110 naphthenic base oils are available in a wide range of viscosities, ranging from very low viscosity products, perfect for hydraulic fluids, to high viscosity products, more suitable for applications such as industrial gear oils

NYNAS T 110 naphthenic base oils are used as base fluids in the formulation of many types of industrial lubricants, alone or in blends with other base fluids.
Their high solvency power contributes not only to the good solubility of additives in these formulations, but also to dissolve deposits and oxidation products during the use phase of the lubricants.


The high solvency also allows them to improve the seal compatibility, something of great importance in many applications, such as hydraulic fluids and gear oils.
Their outstanding low temperature properties help naphthenic oils to improve the low temperature properties of the lubricant formulations where they are used.
Moreover, naphthenic base oils are available in a wide range of viscosities, ranging from very low viscosity products extensively used in aviation hydraulics, to high viscosity products more suitable for applications such as industrial gear oils.



SAFETY INFORMATION ABOUT NYNAS T 110:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product


O-AMINOPHENOL
OCTADECANE, N° CAS : 593-45-3. Nom INCI : OCTADECANE. Nom chimique : Octadecane. N° EINECS/ELINCS : 209-790-3. Ses fonctions (INCI) : Emollient : Adoucit et assouplit la peau, Agent d'entretien de la peau : Maintient la peau en bon état. Solvant : Dissout d'autres substances. Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques
o-Chloro Benzaldehyde
N-(Carboxymethyl)-N-(phosphonomethyl)glycine; Phosphonomethyliminodiacetic acid; N-(phosphonomethyl)iminodiacetic acid; Glycine, N-(carboxymethyl)-N-(phosphonomethyl) cas no : 5994-61-6
o-CHLOROBENZALDEHYDE
o-chlorobenzaldehyde is a chlorinated derivative of benzaldehyde that is used in production of CS gas.
o-chlorobenzaldehyde is a colorless or light yellow oily liquid.


CAS Number: 89-98-5
EC Number: 201-956-3
MDL number: MFCD00003304
Linear Formula: ClC6H4CHO
Chemical formula: C7H5ClO


o-Chlorobenzaldehyde is a clear colorless to yellowish liquid.
o-Chlorobenzaldehyde is a chlorinated derivative of benzaldehyde that is used in production of CS gas.
o-Chlorobenzaldehyde reacts with malononitrile to form CS


o-Chlorobenzaldehyde is a colorless or light yellow oily liquid.
The melting point of o-Chlorobenzaldehyde is 11.6℃, the boiling point is 212.5℃, the relative density is 1.2483(20/4℃), the refractive index is 1.5662, and the flash point is 87.7℃.


o-Chlorobenzaldehyde is slightly soluble in water, and soluble in ethanol, ether, acetone, and benzene.
o-Chlorobenzaldehyde has a strong aldehyde smell.
o-Chlorobenzaldehyde is a chlorinated derivative of benzaldehyde that is used in production of CS gas.


o-Chlorobenzaldehyde reacts with malononitrile to form CS.
o-Chlorobenzaldehyde is a colourless to brown liquid
o-Chlorobenzaldehyde is a clear colorless to yellowish liquid.


o-Chlorobenzaldehyde is soluble in water (1.8g/L), alcohol, ether, benzene, and acetone.
o-Chlorobenzaldehyde is an organic compound with a chlorinated benzene ring and an aldehyde functional group.
o-Chlorobenzaldehyde is a colorless or light yellow oily liquid.


o-Chlorobenzaldehyde is slightly soluble in water, soluble in ethanol, ether, acetone and benzene.
o-Chlorobenzaldehyde has a strong aldehyde smell.
Downstream can synthesize sodium o-benzaldehyde sulfonate, which is a very common dye intermediate.


o-Chlorobenzaldehyde can synthesize fluorescent brightener CBS.
O-chlorobenzoxime can be obtained by oximation of o-chlorobenzaldehyde, and o-chlorobenzoxime can be obtained by further chlorination, both of which are pharmaceutical intermediates.



USES and APPLICATIONS of o-CHLOROBENZALDEHYDE:
o-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas.
o-Chlorobenzaldehyde is a compound useful in organic synthesis used in the preparation and antimicrobial activity of indazolone derivatives.


o-Chlorobenzaldehyde is used Chemical synthesis, Crop Protection, Finishing of metals, Manufacturing of antibiotics, Manufacturing of dyestuffs, Manufacturing of insecticides / acaricides, Manufacturing of pharmaceutical agents, Manufacturing photochemical, Manufacturing of textile dyestuffs, Manufacturing textiles dyestuffs, Optical brighteners, and Textile dyestuffs.


o-Chlorobenzaldehyde is used as medicine, dye intermediates. Zinc brightener
o-Chlorobenzaldehyde is used as dye, pesticide, pharmaceutical intermediates
o-Chlorobenzaldehyde is used for synthesis.


o-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas.
o-Chlorobenzaldehyde can be used to make alcohols, acids, and dyes; used in the rubber, tanning, and paper industries.


o-Chlorobenzaldehyde can also be used to prepare triphenyl methane and related dyes, organic intermediate.
o-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas.


o-Chlorobenzaldehyde is used acid zinc plating brightener, also be used for organic synthesis, agricultural pesticide and pharmaceutical industries.
o-Chlorobenzaldehyde is used to synthesize the acaricides clofentezine and flutenzine.
o-Chlorobenzaldehyde undergoes alkynylation with phenylacetylene in the presence of catalytic ligands and dimethylzinc at 0°C to form binaphthyl-derived amino alcohols.


o-Chlorobenzaldehyde is used Agricultural Chemicals, Agriculture Intermediates, Industrial Chemicals, Pharmaceutical & Fine Chemicals, Pharmaceutical Intermediates, Pesticides
o-Chlorobenzaldehyde is mainly used in the manufacture of o-chlorobenzyl crotch, o-chlorobenzyl crotide chloride and chlorphenazol penicillin sodium and other main raw materials for pharmaceuticals.


o-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas.
o-Chlorobenzaldehyde can be used to make alcohols, acids, and dyes; used in the rubber, tanning, and paper industries.


o-Chlorobenzaldehyde used as an intermediate for optical brighteners, agricultural chemicals, and pharmaceuticals.
o-Chlorobenzaldehyde can also be used to prepare triphenyl methane and related dyes, organic intermediate.
o-Chlorobenzaldehyde is used as brightener in acid zinc electroplating baths at a concentration of 50-150mg/L.


o-Chlorobenzaldehyde can also be used for pharmaceutical industries.
o-Chlorobenzaldehyde can be used as organic synthesis, intermediate in pigment.
o-Chlorobenzaldehyde can also be used in agricultural pesticide.


o-Chlorobenzaldehyde is used as medicine and dye intermediate.
o-Chlorobenzaldehyde is used in the production of clofetezine, o-chlorobenzenealdoxime and DL-2-chlorophenylglycine
o-Chlorobenzaldehyde is the main inermediate of fluorescent brightening agent CBS, triphenyl methane and mothproofing agent.


o-Chlorobenzaldehyde is used acid zinc plating brightener, also be used for organic synthesis, agricultural pesticide and pharmaceutical industries.
o-Chlorobenzaldehyde is used to synthesize the acaricides clofentezine and flutenzine.
o-Chlorobenzaldehyde is mainly used to synthesize oxacillin in medicine.


o-Chlorobenzaldehyde is used as medicine and dye intermediate.
The pesticide Mithijing produced with o-chlorobenzaldehyde can control mites on dry crops and fruit trees.
o-Chlorobenzaldehyde is used to synthesize the pesticide Mizaojin, which can control the mites on dry crops and fruit trees, and can also be used as the intermediate of plant growth regulator indole ester.


Pharmaceutical use of o-Chlorobenzaldehyde: mainly used to synthesize o-chlorobenzoyl chloride, cloxacillin sodium and o-chlorobenzaldehyde oxime.
Fine chemical use of o-Chlorobenzaldehyde is applicable to brightener for zinc plating, that is, brightener for electroplating.
o-Chlorobenzaldehyde is used as medicine and dye intermediate.


The pesticide Mizijing produced with o-6 and chlorobenzaldehyde can control mites on dry crops and fruit trees.
O-chlorobenzoxime can be obtained by oximation of o-chlorobenzaldehyde, and o-chlorobenzoxime can be obtained by further chlorination, both of which are pharmaceutical intermediates.


o-Chlorobenzaldehyde is used as a dye intermediate, pesticide and pharmaceutical intermediate.
o-chlorobenzaldehyde is also used for organic synthesis.
o-Chlorobenzaldehyde is the raw material for the synthesis of acaricide tetrazine.


Galvanizing brightener, mainly used for manufacturing main raw materials of medical medicine such as o-chlorobenzoyl chloride, o-chlorobenzoyl chloride and cloxacillin sodium, and also widely used for manufacturing efficient acaricide on pesticides and raw materials of acaricide products.
o-Chlorobenzaldehyde is used Determination of sorbitol.


o-Chlorobenzaldehyde can also be used for the synthesis of another new acaricide, flutenzine, and can also be used as a pharmaceutical and dye intermediate.
o-Chlorobenzaldehyde is mainly used to synthesize Cloxacillin.
o-Chlorobenzaldehyde is used in preparation of triphenylmethane.


o-Chlorobenzaldehyde is used Dye intermediates.
o-chlorobenzaldehyde is mainly used in the manufacture of o-chlorobenzyl crotch, o-chlorobenzyl crotide chloride and chlorphenazol penicillin sodium and other main raw materials for pharmaceuticals.
o-Chlorobenzaldehyde is used as an intermediate for optical brighteners, agricultural chemicals, and pharmaceuticals.


CHEMICAL PROPERTIES OF o-CHLOROBENZALDEHYDE:
o-Chlorobenzaldehyde is a colorless to yellowish liquid with a penetrating odor.
o-Chlorobenzaldehyde is insoluble in water, soluble in benzene, alcohol and ether.
o-Chlorobenzaldehyde is considerably more resistant to oxidation than benzaldehyde.
When o-Chlorobenzaldehyde is heated with sodium sulfite solution under pressure, benzaldehyde-2-sulfonic acid forms.



MARKETS OF o-CHLOROBENZALDEHYDE:
Agriculture & Animal Care, Chemical & Materials Manufacturing, Personal Care & Pharmaceutical



PREPARATION OF o-CHLOROBENZALDEHYDE:
o-Chlorobenzaldehyde is produced mainly by chlorination of 2-chlorotoluene to form 2-chlorobenzal chloride, which is then subjected to acid hydrolysis.
Metal salts, such as iron(III) chloride, are used as catalysts.
The hydrolysis can also be accomplished using formic acid without a catalyst.
o-Chlorobenzaldehyde can also be produced by oxidation of 2-chlorobenzyl chloride with N-oxides of tertiary amines or with dilute nitric acid.



PHYSICAL AND CHEMICAL PROPERTIES OF o-CHLOROBENZALDEHYDE:
*Colorless or pale yellow oily liquid.
*Melting point 12.39 ℃(11 ℃), boiling point 211.9 ℃(213-214 ℃),84.3 ℃(1.33kPa), relative density 1.2483(20/4 ℃), refractive index 1.5662. *Flashpoint 87.
*Slightly soluble in water, soluble in ethanol, ether, acetone and benzene.
*There is a strong aldehyde odor.



AIR AND WATER REACTIONS OF o-CHLOROBENZALDEHYDE:
Air & Water Reactions
o-Chlorobenzaldehyde is moisture and light-sensitive.
o-Chlorobenzaldehyde is slightly water soluble.



REACTIVITY PROFILE OF o-CHLOROBENZALDEHYDE:
o-Chlorobenzaldehyde reacts with iron and strong oxidizers, strong bases, and strong reducing agents.



PURIFICATION METHODS OF o-CHLOROBENZALDEHYDE:
Wash it with 10% Na2CO3 solution, then fractionally distil o-Chlorobenzaldehyde in the presence of a small amount of catechol as stabiliser.



MANUFACTURING INFORMATION OF o-CHLOROBENZALDEHYDE:
o-Chlorobenzaldehyde has the following synthetic methods.
1. Chlorination and hydrolysis of o-chlorotoluene:
o-chlorobenzaldehyde is obtained by chlorination and hydrolysis of o-chlorotoluene.

① Chlorination: heat o-chlorotoluene, phosphorus trichloride and sulfoxide chloride to 150 ℃, and pass chlorine gas to theoretical amount under ultraviolet irradiation to obtain o-chlorobenzylidene dichloride.

② Hydrolysis: heat the mixture of o-chlorobenzylidene dichloride and zinc chloride at 120~130 ℃, stir and add 1% ferric chloride aqueous solution.
After the addition, heat the mixture and return with water.
The oil layer is refined o-chlorobenzaldehyde.

In addition, hydrolysis can also be carried out in the presence of sulfuric acid.
Stir o-chlorobenzylidene dichloride and industrial concentrated sulfuric acid together until the temperature automatically decreases and the hydrogen chloride escape slows down, and then slowly heat for 12h to keep the temperature at 30-40 ℃; After the reaction, the finished product is obtained by layering with cold water, separating the oily substance, washing and steam distillation.



PHYSICAL and CHEMICAL PROPERTIES of o-CHLOROBENZALDEHYDE:
Chemical formula: C7H5ClO
Molar mass: 140.57 g·mol−1
Density: 1.25
Melting point: 9–12 °C (48–54 °F; 282–285 K)
Boiling point: 209–215 °C (408–419 °F; 482–488 K)
Physical state: liquid
Color: clear, to, yellow
Odor: No data available
Melting point/freezing point:
Melting point/range: 9 - 11 °C - lit.
Initial boiling point and boiling range: 209 - 215 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 97 °C - closed cup - ISO 2719
Autoignition temperature: 360 °C at 1.000 hPa - DIN 51794
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 1,47 g/l at 20 °C

Partition coefficient: n-octanol/water:
log Pow: 2,44 at 25 °C - Bioaccumulation is not expected.
Vapor pressure: < 0,1 hPa at 20 °C
Density: 1,248 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Boiling point: 211.9°C
Melting point: 12.4°C
Relative density (water = 1): 1.25
Solubility in water: miscible
Vapour pressure, kPa at 25°C: 0.04
Flash point: 90°C c.c
Auto-ignition temperature: 385°C
CAS Number: 89-98-5
Molecular Formula: C₇H₅ClO
Appearance: Colourless Oil
Melting Point: No data available

Molecular Weight: 140.57
Storage: 4°C, Hygroscopic
Solubility: Acetonitrile (Slightly), DMSO (Soluble), Methanol (Slightly)
StabilityAir sensitive, Hygroscopic
Melting Point: 10°C to 11.5°C
Color: Colorless to Yellow
Density: 1.2500g/mL
Boiling Point: 209°C to 215°C
Flash Point: 87°C
Infrared Spectrum: Authentic
Assay Percent Range: 98.5% min. (GC)
Linear Formula: ClC6H4CHO
Refractive Index: 1.5650 to 1.567
Beilstein: 07, 233
Specific Gravity:1.25
Solubility Information:
Solubility in water: practically insoluble in water
Formula Weight: 140.57
Percent Purity: 99%
Physical Form: Liquid
Chemical Name or Material: 2-Chlorobenzaldehyde, 99%

Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.24800 @ 25.00 °C.
Melting Point: 12.40 °C. @ 760.00 mm Hg
Boiling Point: 211.90 °C. @ 760.00 mm Hg
Vapor Pressure: 0.178000 mmHg @ 25.00 °C. (est)
Flash Point: 190.00 °F. TCC ( 87.78 °C. )
logP (o/w): 2.330
Soluble in: water, 852.6 mg/L @ 25 °C (est)
CAS number: 89-98-5
EC index number: 605-011-00-X
EC number: 201-956-3
Hill Formula: C₇H₅ClO
Molar Mass: 140.6 g/mol
HS Code: 2913 00 00
Density: 1.248 g/cm3 (25 °C)
Flash point: 97 °C
Ignition temperature: 397 °C
Melting Point: 9 - 11 °C

pH value: 2.9 (H₂O) (saturated aqueous solution)
Vapor pressure: Solubility: 1.8 g/l
Molecular form: C7H5ClO
Appearance: Clear Colourless Oil
Mol. Weight: 140.57
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: NA
Physical State :Liquid
Solubility :Soluble in water (partly), alcohol, ether, benzene, and acetone.
Storage :Store at room temperature
Melting Point :9-11° C (lit.)
Boiling Point :209-215° C (lit.)
Density :1.25 g/mL at 25° C
Refractive Index :n20D 1.57 (lit.)
Molecular Weight: 140.57
Exact Mass: 140.57
BRN: 385877
EC Number: 201-956-3

UNII: QHR24X1LXK
ICSC Number: 0641
NSC Number: 15347
UN Number: 3265
DSSTox ID: DTXSID5024764
Color/Form: Colorless to yellowish liquid|Needles|Liquid or needles
HScode:29130000
PSA: 17.1
XLogP3: 2.33
Appearance: Clear colorless to light yellow Liquid
Density: 1.2483 g/cm3 @ Temp: 20 °C
Melting Point: 12.39 °C
Boiling Point: 211.9 °C @ Press: 760 Torr
Flash Point: 190 °F
Refractive Index: 1.585
Water Solubility: H2O: 0.1-0.5 g/100 mL at 24 ºC
Storage Conditions: -20°C Freezer
Vapor Pressure: 1.27 mm Hg ( 50 °C)
Vapor Density: 4.84 (vs air)
Odor: Penetrating odor
Henrys Law Constant: Henry's Law constant = 2.39X10-5 atm-cu m/mol at 25 °C (est)

Experimental Properties:
UV: 15920 /Benzaldehyde, 3-chloro/|Powder /p-Chlorobenzaldehyde/
Air and Water Reactions: This chemical is moisture and light sensitive.
Slightly water soluble.
Reactive Group: Aldehydes
Reactivity Profile: 2-CHLOROBENZALDEHYDE reacts with iron and strong oxidizers, strong bases and strong reducing agents.
Melting point: 9-11 °C (lit.)
Boiling point: 209-215 °C (lit.)
Density: 1.248 g/mL at 25 °C (lit.)
vapor density: 4.84 (vs air)
vapor pressure: 1.27 mm Hg ( 50 °C)
refractive index: n20/D 1.566(lit.)
Flash point: 190 °F
storage temp.: Store in RT
solubility: 1.8g/l
form: Liquid
color: Clear colorless to light yellow
PH: 2.9 (H2O)(saturated aqueous solution)
Water Solubility: 0.1-0.5 g/100 mL at 24 ºC
Sensitive: Air Sensitive

BRN: 385877
Stability: Stable.
LogP: 2.44 at 25℃
Autoignition Temperature: 743 °F (NTP, 1992)|385 °C
Molecular Formula: C7H5ClO
Molar Mass: 140.57
Density: 1.248 g/mL at 25 °C (lit.)
Melting Point: 9-11 °C (lit.)
Boling Point: 209-215 °C (lit.)
Flash Point: 190°F
Water Solubility: 0.1-0.5 g/100 mL at 24 ºC
Solubility: 1.8g/l
Vapor Presure: 1.27 mm Hg ( 50 °C)
Vapor Density: 4.84 (vs air)
Appearance: Liquid
Color: Clear colorless to light yellow
BRN: 385877
PH: 2.9 (H2O)(saturated aqueous solution)
Storage Condition: Store in RT
Stability: Stable.
Sensitive: Air Sensitive
Refractive Index: n20/D 1.566(lit.)

Density: 1.2±0.1 g/cm3
Boiling Point: 211.9±0.0 °C at 760 mmHg
Melting Point: 9-11 °C(lit.)
Molecular Formula: C7H5ClO
Molecular Weight: 140.567
Flash Point: 87.8±0.0 °C
Exact Mass: 140.002899
PSA: 17.07000
LogP: 2.33
Vapour density: 4.84 (vs air)
Vapour Pressure: 0.2±0.4 mmHg at 25°C
Index of Refraction: 1.585
Stability: Stable.
Water Solubility: 0.1-0.5 g/100 mL at 24 ºC
CAS Number: 89-98-5
EC Numberr: 201-956-3
PubChem CID: 6996
Chemical Name: 2-Chlorobenzaldehyde
IUPAC Name: 2-chlorobenzaldehyde
InChI: InChI=1S/C7H5ClO/c8-7-4-2-1-3-6(7)5-9/h1-5H
InChIKey: FPYUJUBAXZAQNL-UHFFFAOYSA-N
SMILES: Clc1ccccc1C=O
MDL Number: MFCD00003304
MW: 140.56
MF: C7H5ClO
Cat Number: OR12010



FIRST AID MEASURES of o-CHLOROBENZALDEHYDE:
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
*If inhaled:
After inhalation:
Fresh air.
Call in physician
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Call a physician immediately.
*In case of eye contact.
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Call a physician immediately.
Do not attempt to neutralise.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of o-CHLOROBENZALDEHYDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of o-CHLOROBENZALDEHYDE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of o-CHLOROBENZALDEHYDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 30 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type ABEK
-Control of environmental exposure
Do not let product enter drains.



HANDLING and STORAGE of o-CHLOROBENZALDEHYDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep locked up or in an area accessible only to qualified or authorized persons.



STABILITY and REACTIVITY of o-CHLOROBENZALDEHYDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available



SYNONYMS:
2-Chlorobenzaldehyde
o-Chlorobenzaldehyde
O-Chloro-benzaldehyde
2-Chlorobenzaldehyde
2-Chlorobenzoic Aldehyde
2-Chlorophenylcarboxaldehyde
NSC 15347
O-Chlorobenzaldehyde
O-Chlorobenzenecarboxaldehyde
O-Chloroformylbenzene
o-CBA
o-Chloroaldehyde
o-Chlorobenzaldehyde
2-Chlorobenzaldehyde
1-Chloro-2-formylbenzene
O-Chloro-benzaldehyde
2-Chlorobenzaldehyde
2-Chlorobenzoic Aldehyde
2-Chlorophenylcarboxaldehyde
NSC 15347
O-Chlorobenzaldehyde
O-Chlorobenzenecarboxaldehyde
O-Chloroformylbenzene
o-Chloroformylbenzene
Benzaldehyde, 2-chloro-
2-Chlorbenzaldehyd
o-chloro-benzaldehyde
ortho-chloro benzaldehyde
USAF m-7
2-Clorobenzaldeide
ORTHOCHLOROBENZALDEHYDE
O-CHLOROBENZALDEHYDE( OCBA)
2-CHLOROBENZALDEHYDE (1 LT )
o -Chlorobenzaldehyde
o-Chlor-benzaldehyd
O CHLOROBENZALDEHYDE
OCAD
o-chloro-benzaldehyd
2-chloro-benzaldehyde
o-Chlorobenzaldehyde
2-CHLOROBENZALDEHYDE FOR PHARMA SYNTHESIS
Benzaldehyde,2-chloro-
Benzaldehyde,o-chloro-
2-Chlorobenzaldehyde
o-Chlorobenzaldehyde
o-Chlorobenzenecarboxaldehyde
2-Chlorobenzoic aldehyde
o-Chloroformylbenzene
NSC 15347
2-Chlorophenylcarboxaldehyde
OCAD
OCBA
2-Chlorobenzaldehyde
O-CHLOROBENZALDEHYDE
Amlodipine Impurity T
2 chloro benzaldehyde
Chlorobenzaldehyde, 2-
ortho-chlorobenzaldehyde
ORTHO CHLORO BENZALDEHYDE
2-CHLOROBENZALDEHYDE, DIST
OCBA(2-Chlorobenzaldehyde )
2-chlorobenzaldehyde radical
O-chlorobenzenecarboxyaldehyde
2-ChlorobenzaldehydeForSynthesis
o-Chlorobenzaldehyde
2-Chlorobenzaldehyde
ORTHO CHLORO BENZALDEHYDE
OCBA
O-CHLOROBENZALDEHYDE
OCAD
2-Clorobenzaldeide
usafm-7
USAF m-7
NSC 15347
AKOS BBS-00003191
2-Chlorbenzaldehyd
benzaldehyde, 2-chloro-
2-chloro-benzaldehyde
o-chlorobenzaldehyde
ortho-chlorobenzaldehyde
ortho-chlorobenzenecarboxaldehyde
o-chlorobenzenecarboxyaldehyde
o-chloroformylbenzene
Benzaldehyde, o-chloro-
o-Chlorobenzaldehyde
2-Chlorobenzaldehyde
o-Chloorbenzaldehyde
USAF M-7
2-Chlorbenzaldehyd
2-Clorobenzaldeide
o-Chlorobenzenecarboxaldehyde
o-Chloroformylbenzene
NSC 15347


o-Chloro-p-nitroaniline
o-Chloro-p-Nitro Aniline; OCPNA; Ortho Chloro Para Nitro Aniline; 2-chloro-4-nitrobenzenamine; 2-chloro- 4-nitroaniline; OCPN; 1-amino-2-chloro-4-nitrobenzene; 4-NITRO-2-CHLOROANILINE; CAS NO:121-87-9
Octadecane
OCTADECENEDIOIC ACID, N° CAS : 20701-68-2. Nom INCI : OCTADECENEDIOIC ACID. Nom chimique : 9-Octadecenedioic acid. Ses fonctions (INCI) ; Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile)
Octadecanedioic Acid
propyl alcohol; propan-1-ol; propanol; 1- propanol; propanol natural; propylic alcohol cas no : 71-23-8
OCTADECANOIC ACID
Octadecanoic acid is widely utilized in pharmaceuticals and cosmetics due to its properties as a lubricant, release agent, and its ability to delay dissolution, making it an essential ingredient in tablet production.
In addition to its role in pharmaceuticals, Octadecanoic acid finds applications in various sectors such as cosmetics, food, polymer, rubber, and paint industries, where it serves multiple functions including gelling, stabilizing, antiadhesive, and plasticizing.
As a versatile additive, Octadecanoic acid serves as a flow agent in capsules and tablets, enhancing consistency and quality control, while also finding utility in the food industry as an emulsifier, binder, thickener, and anticaking agent.

CAS Number: 557-04-0
EC Number: 209-150-3
Molecular Formula: C36H70MgO4
Molecular Weight (g/mol): 591.257

Synonyms: 209-150-3 [EINECS], 3919702 [Beilstein], 557-04-0 [RN], 70097M6I30, Dibasic magnesium stearate, Dioctadécanoate de magnésium [French] [ACD/IUPAC Name], Magnesium dioctadecanoate [ACD/IUPAC Name], MAGNESIUM OCTADECANOATE, Magnesium stearate [JAN] [JP15] [NF] [USP], Magnesiumdioctadecanoat [German] [ACD/IUPAC Name], MFCD00036391 [MDL number], OCTADECANOIC ACID MAGNESIUM SALT, Octadecanoic acid, magnesium salt, Octadecanoic acid, magnesium salt (2:1) [ACD/Index Name], stearic acid magnesium salt, Stearic acid, magnesium salt, synpro 90, Synpro Magnesium Stearate 90, WI4390000, (OCTADECANOYLOXY)MAGNESIO OCTADECANOATE, [557-04-0] [RN], 212132-26-8 [RN], EINECS 209-150-3, Magnesium [ACD/Index Name] [ACD/IUPAC Name], magnesium distearate, Magnesium stearate (contain palmitic acid), Magnesium stearate (JP17/NF), Magnesium Stearate NF, Magnesium Stearate NF EP FCC Kosher, MAGNESIUM(2+) DIOCTADECANOATE, MAGNESIUM(2+) ION BIS(N-OCTADECANOATE), magnesium(2+) ion bis(octadecanoate), Magnesium(II) Stearate, magnesiumstearate, octadecanoate, PARTECK LUB MST, Petrac MG 20NF, SM-P, UNII:70097M6I30, UNII-70097M6I30, 硬脂酸镁 [Chinese], MAGNESIUM STEARATE, 557-04-0, Magnesium octadecanoate, Magnesium distearate, Dibasic magnesium stearate, Octadecanoic acid, magnesium salt, magnesium(ii) stearate, Synpro 90, Petrac MG 20NF, Stearic acid, magnesium salt, NS-M (salt), SM-P, Magnesium stearate g, Synpro Magnesium Stearate 90, HSDB 713, Magnesii stearas, Magnesium distearate, pure, EINECS 209-150-3, NP 1500, SM 1000, CHEBI:9254, AI3-01638, magnesium dioctadecanoate, UNII-70097M6I30, Octadecanoic acid, magnesium salt (2:1), 70097M6I30, DTXSID2027208, MAGNESIUM STEARATE (II), MAGNESIUM STEARATE [II], Magnesium stearate [JAN], C36H70MgO4, Magnesium stearate [JAN:NF], DAYCLING, Magnesium stearate, tech, SCHEMBL935, DTXCID307208, Magnesium stearate (JP17/NF), MAGNESIUM STEARATE [MI], CHEMBL2106633, MAGNESIUM STEARATE [HSDB], MAGNESIUM STEARATE [INCI], Stearic Acid Magnesium(II) Salt, MAGNESIUM STEARATE [VANDF], HY-Y1054, MAGNESIUM STEARATE [WHO-DD], AKOS015915201, DB14077, MAGNESII STEARAS [WHO-IP LATIN], CS-0016049, NS00080495, S0238, D02189, A830764, Q416713

Octadecanoic acid is the chemical compound with the formula Mg(C18H35O2)2.
Octadecanoic acid is a soap, consisting of salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+).

Octadecanoic acid is a white, water-insoluble powder.
Octadecanoic acid's applications exploit its softness, insolubility in many solvents, and low toxicity.
Octadecanoic acid is used as a release agent and as a component or lubricant in the production of pharmaceuticals and cosmetics.

Octadecanoic acid is the magnesium salt of stearic acid.
Octadecanoic acids anhydrate, dihydrate and trihydrate forms have been prepared.

The tabletting of the blends of Octadecanoic acid and lactose granules has been described.
The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined.

Octadecanoic acid is widely used lubricant in pharmaceutical industry.
Octadecanoic acid also plays a role in delaying the process of dissolution.
Octadecanoic acids detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Octadecanoic acid, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.

Octadecanoic acid is towards plastic applications.
Octadecanoic acid is used as gelling agent, stabilizer, antiadhesive and plasticizer as a lot of different functions in primary sectors ;cosmetics, pharmacy, food, polymer, rubber and paint.
Octadecanoic acid can be manufactured with demanded particular size and density, according to production process and industry.

Octadecanoic acid is involved in the production of medical tablets, capsules, powders and polymer formulation.
Octadecanoic acid is also used as a lubricant for tablets, anti-adherent, in dry coating and as a binding agent.
Octadecanoic acid is an important ingredient in baby formulas.

Further, Octadecanoic acid is used in the hydrogenation process.
In addition to this, Octadecanoic acid is used to bind the sugar in hard candies like mints.

Octadecanoic acid is a white, water-insoluble fine powder.
Octadecanoic acid is a simple salt made up of two substances, a saturated fat called stearic acid and the mineral magnesium.

Octadecanoic acid is the most common additive that is primarily used in capsules and tablets as it is considered a ‘flow agent’ so Octadecanoic acid prevents the individual ingredients in a capsule from sticking together.

Octadecanoic acid helps improves the consistency and quality control of capsules.
Octadecanoic acid is used in the food industry as an emulsifier, binder and thickener, as well as an anticaking, lubricant, and antifoaming agent.

Octadecanoic acid is the magnesium salt of stearic acid.
Octadecanoic acids anhydrate, dihydrate and trihydrate forms have been prepared.

The tabletting of the blends of Octadecanoic acid and lactose granules has been described.
The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined.

Octadecanoic acid is widely used lubricant in pharmaceutical industry.
Octadecanoic acid also plays a role in delaying the process of dissolution.
Octadecanoic acids detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Octadecanoic acid is a fine white powder that adds bulk to cosmetic and personal care products, while also providing them with a rich slippery feeling and adhesion.
Octadecanoic acid makes products feel good to the touch and enhances the spreadability.
Octadecanoic acid can also act as a lubricant and an anti-caking agent.

Octadecanoic acid is generally found in products like creams, lotions, and powders where Octadecanoic acid improves the overall performance and shelf life of the formulation.
Octadecanoic acid is soluble in hot water and has the formula Mg(C18H35O2)2.

Octadecanoic acid, a synthetic soap that consists of a mixture of magnesium salts of fatty acids, principally palmitic and stearic acid.
Octadecanoic acid is one of the most commonly used excipients and corresponds to the chemical formula, C36H70MgO4.

Octadecanoic acid is described in pharmacopoeia as a mixture of organic acids, chiefly Octadecanoic acid, and magnesium palmitate.
Octadecanoic acid is supplied as a very fine, light, white impalpable powder.
When touched, Octadecanoic acid feels greasy and readily adheres to the skin.

Octadecanoic acid is a solid, white powder at room temperature.
Octadecanoic acid is a FDA-approved inactive ingredient commonly used in the pharmaceutical industry as a lubricant and release agent in the manufacture of tablet, capsule, and powder dosage forms.

Octadecanoic acid is generally recognized as safe by the FDA.
Octadecanoic acid exists as a salt form and is useful for it's lubricating properties for capsules and tablets in industry.

Octadecanoic acid is used to help prevent pharmaceutical ingredients from adhering to industry equipment.
Octadecanoic acid may be derived from both plant and animal sources.

Octadecanoic acid is a common additive used in the pharmaceutical industry.
Octadecanoic acid is a white, odorless, and tasteless powder that is highly insoluble in water, but soluble in organic solvents.
The chemical formula for Octadecanoic acid is Mg(C18H35O2)2.

Have you ever wondered what that coating on your medications and vitamins is? It’s an additive made from Octadecanoic acid.

Octadecanoic acid is a fine white powder that sticks to your skin and is greasy to the touch.
Octadecanoic acid’s a simple salt made up of two substances, a saturated fat called stearic acid and the mineral magnesium.

Stearic acid can also be found in many foods, such as:
chicken
eggs
cheese
chocolate
walnuts
salmon
cotton seed oil
palm oil
coconut oil

Octadecanoic acid is commonly added to many foods, pharmaceuticals, and cosmetics.
In medications and vitamins, Octadecanoic acid's primary purpose is to act as a lubricant.

Uses of Octadecanoic acid:
Octadecanoic acid is often used as an anti-adherent in the manufacture of medical tablets, capsules and powders.
In this regard, the substance is also useful because Octadecanoic acid has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; Octadecanoic acid is the most commonly used lubricant for tablets.
However, Octadecanoic acid might cause lower wettability and slower disintegration of the tablets and slower and even lower dissolution of the drug.

Octadecanoic acid can also be used efficiently in dry coating processes.

In the production of pressed candies, Octadecanoic acid serves as a release agent.
Octadecanoic acid is also used to bind sugar in hard candies such as mints.

Octadecanoic acid is a common ingredient in baby formulas.
In the EU and EFTA Octadecanoic acid is listed as food additive E470b.

Uses of Octadecanoic acid as excipient in pharmaceuticals:
Octadecanoic acid is a widely used excipient in the pharmaceutical industry, serving a variety of purposes in drug formulation and manufacturing.

Here are some of the major uses of Octadecanoic acid in pharmaceutical products:

Lubricant:
One of the most common uses of Octadecanoic acid in pharmaceutical products is as a lubricant.
Octadecanoic acid is added to drug formulations to reduce friction between particles and facilitate their movement through manufacturing equipment, such as tablet presses and capsule filling machines.

This helps to ensure consistent and efficient production of drug products.
Octadecanoic acid is used as a lubricant for tablets and capsules in a range of 0.2 to 5%.

Anti-adherent:
Octadecanoic acid can also serve as an anti-adherent in pharmaceutical products.
Octadecanoic acid is added to prevent drug particles from sticking to the surfaces of manufacturing equipment, which can cause blockages or uneven dosing.

Flow agent:
In addition to lubrication, Octadecanoic acid can also improve the flow properties of drug powders.
Octadecanoic acid is added to reduce the cohesive forces between particles and improve their flowability, making Octadecanoic acid easier to handle and process them during manufacturing.

Octadecanoic acid has various uses in both cosmetics and skincare products.
Primarily, Octadecanoic acid enhances the texture and performance of formulations within the cosmetic industry.

Cosmetic products:
Octadecanoic acid is a good anti-caking agent that works wonders with cosmetic products.
Octadecanoic acid promotes a slippery texture that enhances the blend and spreadability of products like blushes, eyeshadows, and foundations.
Octadecanoic acid also aids with adherence to allow for long-lasting wear.

Skin care:
Octadecanoic acid is often utilized as a thickening agent and emulsifier.
Octadecanoic acid helps to stabilize and bind the ingredients in creams, lotions, and moisturizers, ensuring a consistent and smooth texture.
Octadecanoic acid also aids in the absorption of oils and active ingredients, facilitating their delivery into the skin for improved efficacy.

Applications of Octadecanoic acid:
Octadecanoic acid may be used as excipient in the formulations of diclofenac sodium tablets.
Octadecanoic acid may be used for the preparation of tramadol HCl matrix tablets.

Manufacturing of Octadecanoic acid:
Octadecanoic acid can be derived from various sources such as animal, vegetable, and synthetic materials.
Animal-derived Octadecanoic acid is usually sourced from beef or pork tallow, while vegetable-derived Octadecanoic acid is obtained from hydrogenated cottonseed or palm oil.
Synthetic Octadecanoic acid is produced by combining magnesium oxide or magnesium hydroxide with stearic acid.

Octadecanoic acid is produced by the reaction of sodium stearate with magnesium salts or by treating magnesium oxide with stearic acid.

Occurrence of Octadecanoic acid:
Octadecanoic acid is a major component of bathtub rings.
When produced by soap and hard water, Octadecanoic acid and calcium stearate both form a white solid insoluble in water, and are collectively known as soap scum.

Origin of Octadecanoic acid:
Octadecanoic acid is generally produced by the reaction between magnesium salts and stearic acid.
Stearic acid is neutralized with magnesium hydroxide or magnesium carbonate, resulting in the formation of Octadecanoic acid.
Octadecanoic acid is then purified, dried, and milled into a fine powder for use in cosmetics and other applications.

Handling and storage of Octadecanoic acid:

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and reactivity of Octadecanoic acid:

Reactivity:
No data available

Chemical stability:
Octadecanoic acid is chemically stable under standard ambient conditions (room temperature).

Possibility of hazardous reactions:
No data available

Conditions to avoid:
no information available

Incompatible materials:
Strong oxidizing agents

Safety of Octadecanoic acid:
Octadecanoic acid is generally considered safe for human consumption at levels below 2500 mg per kg of body weight per day and is classified in the United States as generally recognized as safe (GRAS).
In 1979, the FDA's Subcommittee on GRAS Substances (SCOGS) reported, "There is no evidence in the available information on Octadecanoic acid that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future."

Octadecanoic acid is generally safe for use and has no reported side effects.
Octadecanoic acid also does not clog pores or cause breakouts.

Patch testing of Octadecanoic acid with Octadecanoic acid can be done for sensitive skin, but is not typically required.
Depending on the source and manufacturing of this compound, Octadecanoic acid can be vegan and halal.

First aid measures of Octadecanoic acid:

If inhaled:

After inhalation:
Fresh air.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.

In case of eye contact:

After eye contact:
Rinse out with plenty of water.
Remove contact lenses.

If swallowed:

After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.

Indication of any immediate medical attention and special treatment needed:
No data available

Firefighting measures of Octadecanoic acid:

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture:
Carbon oxides
Magnesium oxide

Advice for firefighters:
In the event of fire, wear self-contained breathing apparatus.

Further information:
none

Accidental release measures of Octadecanoic acid:

Personal precautions, protective equipment and emergency procedures:

Advice for non-emergency personnel:
Avoid inhalation of dusts.
Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental precautions:
No special precautionary measures necessary.

Methods and materials for containment and cleaning up:
Observe possible material restrictions.
Take up dry.

Dispose of properly.
Clean up affected area.
Avoid generation of dusts.

Identifiers of Octadecanoic acid:
CAS Number: 557-04-0
ChEBI: CHEBI:9254
ChemSpider: 10704
ECHA InfoCard: 100.008.320
E number: E572 (acidity regulators, ...)
PubChem CID: 11177
UNII: 70097M6I30
CompTox Dashboard (EPA): DTXSID2027208
InChI: InChI=1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L
InChI=1/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
Key: HQKMJHAJHXVSDF-NUQVWONBAM
SMILES: [Mg+2].[O-]C(=O)CCCCCCCCCCCCCCCCC.[O-]C(=O)CCCCCCCCCCCCCCCCC

CAS: 557-04-0
Molecular Formula: C36H70MgO4
Molecular Weight (g/mol): 591.257
MDL Number: MFCD00036391
InChI Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L
PubChem CID: 11177
ChEBI: CHEBI:9254
IUPAC Name: magnesium;octadecanoate
SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]

Synonym(s): Stearic acid magnesium salt
Linear Formula: [CH3(CH2)16CO2]2Mg
CAS Number: 557-04-0
Molecular Weight: 591.24
Beilstein: 3919702
EC Number: 209-150-3
MDL number: MFCD00036391
PubChem Substance ID: 24865972
NACRES: NA.22

Compound Formula: [CH3(CH2)16CO2]2Mg
Molecular Weight: 591.24
Appearance: White Powder
Melting Point: 200°C
Boiling Point: N/A
Density: N/A
Solubility in H2O: N/A
Exact Mass: 590.512452 g/mol
Monoisotopic Mass: 590.512452 g/mol

Linear Formula: [CH3(CH2)16CO2]2Mg
MDL Number: MFCD00036391
EC No.: 209-150-3
Beilstein/Reaxys No.: 3919702
Pubchem CID: 11177
IUPAC Name: magnesium; octadecanoate
SMILES: CCCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
InchI Identifier: InChI=1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InchI Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Properties of Octadecanoic acid:
Chemical formula: Mg(C18H35O2)2
Molar mass: 591.27 g/mol
Appearance: light white powder
Odor: slight
Density: 1.026 g/cm3
Melting point: 88.5 °C (191.3 °F; 361.6 K)
Solubility in water: 0.003 g/100 mL (15 °C)
0.004 g/100 mL (25 °C)
0.008 g/100 mL (50 °C)
Solubility: negligible in ether and alcohol slightly soluble in benzene

grade: technical grade
Quality Level: 100
form: powder

composition:
palmitate salt, 25%
stearate salt, 65%

mp: 200 °C (lit.)
SMILES string: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InChI key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Specifications of Octadecanoic acid:
Melting Point: 148°C to 152°C
Quantity: 250 g
Solubility Information: Slightly soluble in benzene. Insoluble in water,alcohol and ether.
Formula Weight: 591.27
Chemical Name or Material: Octadecanoic acid

Names of Octadecanoic acid:

IUPAC name:
Magnesium octadecanoate
OCTADECENEDIOIC ACID
SYNONYMS Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecyl ester CAS NO:4813-57-4
OCTADECYL AMINE (ODA)
Octadecyl amine (ODA) is a chemical compound from the group of aliphatic amines.
Octadecyl amine (ODA) is a white solid.
Octadecyl amine (ODA) is an 18-carbon primary aliphatic amine.


CAS Number: 124-30-1
EC Number: 204-695-3
MDL number: MFCD00008159
Linear Formula: CH3(CH2)17NH2
Molecular Formula: C18H39N


Octadecyl amine (ODA) is a flammable white odorless solid which is practically insoluble in water
Octadecyl amine (ODA) is a kind of aliphatic amines compound being subject to industrial mass production.
At room temperature, Octadecyl amine (ODA) is as white crystals with the molecular weight being 269.5, melting point being 52.8612, boiling point being 232.12 (4.27 kPa), the flash point being 149 ℃, the relative density being 0.8618 and the refractive index being 1.4522.


Octadecyl amine (ODA) is slightly soluble in acetone, kerosene and methanol, easily soluble in carbon tetrachloride, chloroform, ethanol, isopropanol and toluene, soluble in alcohol, ether, benzene but insoluble in water.
Octadecyl amine (ODA) has alkaline property and can react with hydrochloric acid to generate adduct product.


Octadecyl amine (ODA), also known as N-stearylamine or 1-aminooctadecane, belongs to the class of organic compounds known as monoalkylamines.
These are organic compounds containing an primary aliphatic amine group.
Octadecyl amine (ODA) is a very strong basic compound (based on its pKa).


Octadecyl amine (ODA) is an 18-carbon primary aliphatic amine.
Octadecyl amine (ODA) appears as white waxy crystalline solid with alkalinity.
Octadecyl amine (ODA) is soluble in chloroform, soluble in alcohol, ether and benzene, slightly soluble in acetone and insoluble in water.


Octadecyl amine (ODA) is in 18-carbon primary aliphatic amine.
Octadecyl amine (ODA) is a white solid.
Octadecyl amine (ODA) is insoluble in water and less dense than water.


Octadecyl amine (ODA) is used to make other chemicals.
Octadecylamine appears as a white solid.
Octadecyl amine (ODA) is an 18-carbon primary aliphatic amine.


Octadecyl amine (ODA) has a role as a film-forming compound.
Octadecyl amine (ODA) appears as a white solid.
Octadecyl amine (ODA) is insoluble in water and less dense than water.


Octadecyl amine (ODA) hence floats on water.
Octadecan-1-amine is an 18-carbon primary aliphatic amine.
Octadecyl amine (ODA) appears as white waxy crystalline solid with alkalinity.


Octadecyl amine (ODA) is soluble in chloroform, soluble in alcohol, ether and benzene, slightly soluble in acetone and insoluble in water.
Combining Octadecyl amine (ODA) and ethylene oxide in a molar ratio of 1:2 and reacting at 150-190°C, octadecyldiethanolamine [10213-78-2] can be obtained in a yield of nearly 80%.


Octadecyldiethanolamine is a non-ionic antistatic agent that can be used in polypropylene, polystyrene, and ABS resins.
Octadecyl amine (ODA) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.


This primary alkyl amine, Octadecyl amine (ODA), with a precise molecular formula of CH3(CH2)17NH2, weighs approximately 269.50 g/mol, giving it a distinctly solid configuration.
Often characterized by its colorless to light-yellow appearance and a distinct amine odor, Octadecyl amine (ODA), also known as ODA, is a standout in the world of organic amines.


Octadecyl amine (ODA) (CAS Number: 124-30-1) is a versatile primary alkylamine, also known as 1-Aminooctadecane or stearylamine.
Octadecyl amine (ODA)'s key role as a hydrophobic surface modifier backs a spectrum of applications, enhancing its value across industries.
Octadecyl amine (ODA) is an 18-carbon primary aliphatic amine.


Octadecyl amine (ODA) is insoluble in water.
Octadecyl amine (ODA) is essentially a hydrophobic surface modifier, thanks to its unique composition of Carbon, Hydrogen, and Nitrogen.
This characteristic sets Octadecyl amine (ODA) aside from its peers, making it an invaluable addition to varied industrial processes.


Octadecyl amine (ODA) appears as a white solid.
Octadecyl amine (ODA) is insoluble in water and less dense than water.
Octadecyl amine (ODA) hence floats on water.



USES and APPLICATIONS of OCTADECYL AMINE (ODA):
Octadecyl amine (ODA) is used to make other chemicals.
Octadecyl amine (ODA) is used to make other chemicals.
Octadecyl amine (ODA) has a role as a film-forming compound.


Octadecyl amine (ODA) is used to induce hydrophobicity in nanodiamond (ND) powders.
Octadecyl amine (ODA) is used in the surface modification of graphite and fullerenes.
Octadecyl amine (ODA) is used as a dual source of carbon and nitrogen in the synthesis of N-doped carbon nanotubes (CNTs).


Octadecyl amine (ODA) can be used as the intermediate for organic syntheses such as for the production of octadecyl quaternary ammonium salts and various kinds of additives such as cationic thickening agent, mineral flotation agents, emulsifier of synthetic resins, pesticides and asphalt, antistatic agents, wetting agents, waterproofing agents, surfactants as well as biocides of fabric, color former of color photo and the corrosion inhibitor of the oil refining device.


Octadecyl amine (ODA) can be generated by the reaction of stearic acid and ammonia for generating octadecanitrile and further catalytic hydrogenation under pressure for further reduction of enamine.
To synthesize a single-chain cationic surfactant, bis(amidoethylcarbamoylethyl) Octadecyl amine (ODA).


Octadecyl amine (ODA) can be used as the intermediates of organic synthesis for the production of octadecyl quaternary ammonium salts and many kinds of additives such as cationic grease thickener, mineral flotation agents, pesticides and asphalt emulsifier, fabric antistatic agents, softeners, wetting agents and waterproofing agents, surfactants, biocides, color former of color photo and the corrosion inhibitor of the oil refining device.


Octadecyl amine (ODA) is used in biological studies for the formation of ion pairing as alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles.
Octadecyl amine (ODA) also forms films which can be used in ion exachnge systems.


Octadecyl amine (ODA) may also be used in the preparation of metal oxide nano crystals with controlled size and shape.
Octadecyl amine (ODA) is used to surface functionalize different carbon nanomaterials (graphene oxide, carbon nanotubes) for different applications which include thin film nanocomposite (TFN) nanofilteration and carbon fiber microelectrodes.


Octadecyl amine (ODA) can be used for the preparation of butyrylcholinesterase/stearylamine films (Langmuir-Blodgett films) for use in enzymatic field effect transistor (ENFET) based biosensors.
Octadecyl amine (ODA) has been used to grow nanocrystals.


Octadecyl amine (ODA) is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Octadecyl amine (ODA) has an industrial use resulting in manufacture of another substance (use of intermediates).


Other release to the environment of Octadecyl amine (ODA) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


Octadecyl amine (ODA) can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and electrical batteries and accumulators.
Octadecyl amine (ODA) is used for the manufacture of: chemicals, textile, leather or fur, rubber products and fabricated metal products.


Octadecyl amine (ODA) can be found in products with material based on: rubber (e.g. tyres, shoes, toys), rubber used for large surface area articles (e.g. construction and building materials for flooring), rubber used for articles with intense direct dermal (skin) contact during normal use (e.g. gloves, boots, clothing, rubber handles, gear lever, steering wheels) and plastic (e.g. food packaging and storage, toys, mobile phones).


Octadecyl amine (ODA) is used in the following products: hydraulic fluids, lubricants and greases, metal working fluids, fuels, fertilisers and heat transfer fluids.
Octadecyl amine (ODA) is used in the following areas: agriculture, forestry and fishing.


Other release to the environment of Octadecyl amine (ODA) is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use as processing aid and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Release to the environment of Octadecyl amine (ODA) can occur from industrial use: formulation of mixtures and formulation in materials.
Octadecyl amine (ODA) is used in the following products: fuels, hydraulic fluids, heat transfer fluids, polymers, lubricants and greases and metal working fluids.


Octadecyl amine (ODA) is used in the following products: fertilisers, fuels, hydraulic fluids, lubricants and greases and metal working fluids.
Octadecyl amine (ODA) is used in the following areas: mining.
Octadecyl amine (ODA) is used for the manufacture of: chemicals.


Release to the environment of Octadecyl amine (ODA) can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release and in processing aids at industrial sites.
Release to the environment of Octadecyl amine (ODA) can occur from industrial use: manufacturing of the substance.


Octadecyl amine (ODA) is used as an intermediate in organic synthesis, used in the production of octadecane quaternary ammonium salt and various additives, such as thickener for cationic grease, mineral processing agent, pesticide and asphalt emulsifier, fabric antistatic agent, softener, moisturizing agent.
Octadecyl amine (ODA) is used as an agent and water repellent, surfactant, fungicide, color formers for color films, and corrosion inhibitors for oil refining units.


Octadecyl amine (ODA) is a chemical compound that can be used as a raw material for the synthesis of colloidal gold.
Octadecyl amine (ODA) has been shown to have significant cytotoxicity and hypoglycemic effects, and is also used in the preparation of liposomes.
Octadecyl amine (ODA) is a component of polymer compositions that are used in the treatment of bowel disease.


Octadecyl amine (ODA) has been shown to increase water vapor permeability and has an electrochemical impedance spectroscopy profile with a rate constant of 0.4 s−1.
Octadecyl amine (ODA) also shows significant antimicrobial activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium difficile, but not against Gram-negative bacteria such as Escherichia coli or Pseudomonas aeruginosa.


Octadecyl amine (ODA) is used To induce hydrophobicity in nanodiamond (ND) powders.
Octadecyl amine (ODA) is used in the surface modification of graphite and fullerenes.
Octadecyl amine (ODA) is used as a dual source of carbon and nitrogen in the synthesis of N-doped carbon nanotubes (CNTs).


Octadecyl amine (ODA) is used to synthesize a single-chain cationic surfactant, bis(amidoethylcarbamoylethyl) octadecylamine.
Octadecyl amine (ODA) is used to grow nanocrystals
Principal Uses of Octadecyl amine (ODA): Creation of Langmuir-Blodgett films, reagents, and in varied chemical syntheses


Octadecyl amine (ODA) is a dependable solution for advanced intermediates, pharmaceutical production, and chemical synthesis, bolstering operational efficiency and outcome quality.
Octadecyl amine (ODA), having a CAS Number of 124-30-1, is highly recognized in the industrial sphere for its versatile applications and robust chemical structure.


Octadecyl amine (ODA)'s popular synonym, 1-Aminooctadecane, also echoes particularly in the circles dealing with raw materials, drugs, and specialty chemicals.
Octadecyl amine (ODA) is used to make other chemicals.



KEY APPLICATIONS OF HIGH-END OCTADECYL AMINE (ODA):
Octadecyl amine (ODA) finds itself an integral part of the paints and coatings industry, superbly augmenting moisture resistance and adhesion attributes.
In adhesives, Octadecyl amine (ODA) underlines its importance by bolstering bonding strength and adding resistance against water and other environmental impacts.

As a surfactant, Octadecyl amine (ODA)'s ability to lower surface tension and augment wetting properties is irreplaceable.
Octadecyl amine (ODA)'s role as a softening agent and additive in textile processes and dyeing units respectively denotes its relevance in the textile industry.
Octadecyl amine (ODA)’s positive imapct on processing and adhesion properties in rubber compound manufacturing is noteworthy.



REACTIVITY PROFILE OF OCTADECYL AMINE (ODA):
Octadecyl amine (ODA) neutralizes acids in exothermic reactions to form salts plus water.
Octadecyl amine (ODA) may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.



PHYSICAL and CHEMICAL PROPERTIES of OCTADECYL AMINE (ODA):
Molecular Weight: 269.5 g/mol
XLogP3: 8.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 16
Exact Mass: 269.308250248 g/mol
Monoisotopic Mass: 269.308250248 g/mol
Topological Polar Surface Area: 26Ų
Heavy Atom Count: 19
Formal Charge: 0
Complexity: 45
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CAS Number: 124-30-1
Molecular Weight: 269.51
Beilstein: 636111

EC Number: 204-695-3
MDL number: MFCD00008159
Melting point : 50-52 °C(lit.)
Boiling point : 232 °C32 mm Hg(lit.)
density: 0.862
vapor pressure : 10 mm Hg ( 72 °C)
refractive index: 1.4522
Fp: 300 °F
storage temp.: Store below +30°C.
form: Prills
pka: 10.6(at 25℃)
color: White
Water Solubility: practically insoluble
FreezingPoint: 53.1℃
BRN: 636111
InChIKey: REYJJPSVUYRZGE-UHFFFAOYSA-N
LogP: 4.33 at 25℃
Boiling point: 132 °C (43 hPa)
Density 0.94 g/cm3 (23.2 °C)
Flash point: 148 °C
Melting Point: 50 - 52 °C

pH value: 11.4 (H₂O, 20 °C)
Vapor pressure: 0.21 Pa (20 °C)
CAS number: 124-30-1
EC index number: 612-282-00-8
EC number: 204-695-3
Hill Formula: C₁₈H₃₉N
Molar Mass: 269.52 g/mol
HS Code: 2921 19 99
IUPAC Name: octadecan-1-amine
Molecular Weight: 269.5g/mol
Molecular Formula: C18H39N;C18H39N
InChI: InChI=1S/C18H39N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h2-19H2,1H3
InChIKey: REYJJPSVUYRZGE-UHFFFAOYSA-N
Boiling Point: 660 °F at 760 mm Hg
Melting Point: 120 to 126 °F
Flash Point: 300 °F
Density: 0.8618 at 68 °F
0.8618 @ 20 °C/4 °C;0.86 g/cm³
Solubility: less than 1 mg/mL at 72° F
Insol in water; sol in alcohol, ether, benzene;
very sol in chloroform; miscible in acetone;
Solubility in water: very poor
Complexity: 145
Covalently-Bonded Unit Count: 1

EC Number: 204-695-3;262-976-6
Exact Mass: 269.30825g/mol
Formal Charge: 0
Hazard Statements: H301
Heavy Atom Count: 19
ICSC Number: 1365
LogP: 7.7
Monoisotopic Mass: 269.30825g/mol
NSC Number: 9857
Refractive IndexIndex of refraction: 1.4522 @ 20 °C
Rotatable Bond Count: 16
RTECS Number: RG4150000
Status: 0
UNI: IFFV58UNY7O
UN Number: 1759
Vapor Density: 9.29 (NTP, 1992) (Relative to Air)
XLogP: 38.5
Physical state: powder
Color: white
Odor: amine-like
Melting point/freezing point
Melting point/range: 50 - 52 °C - lit.
Initial boiling point and boiling range: 232 °C at 43 hPa - lit.

Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 148 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 11,4 at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0,001 g/l - insoluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 0,00 hPa at 20 °C
Density: 0,94 g/cm3 at 23,2 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not explosive
Oxidizing properties: No data available

Other safety information: No data available
Melting point: 50-52 °C(lit.)
Boiling point: 232 °C32 mm Hg(lit.)
Density 0.862
vapor pressure: 10 mm Hg ( 72 °C)
refractive index: 1.4522
Flash point: 300 °F
storage temp.: Store below +30°C.
form: Prills
pka: 10.6(at 25℃)
color: White
Water Solubility: practically insoluble
FreezingPoint: 53.1℃
BRN: 636111
InChIKey: REYJJPSVUYRZGE-UHFFFAOYSA-N
LogP: 4.33 at 25℃
CAS DataBase Reference: 124-30-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS): OCTADECYLAMINE
FDA 21 CFR: 173.310
EWG's Food Scores: 1-3
FDA UNII: FFV58UNY7O



FIRST AID MEASURES of OCTADECYL AMINE (ODA):
-Description of first-aid measures:
*General advice:
Consult a physician.
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of OCTADECYL AMINE (ODA):
-Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
-Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of OCTADECYL AMINE (ODA):
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of OCTADECYL AMINE (ODA):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Face shield and safety glasses
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.



HANDLING and STORAGE of OCTADECYL AMINE (ODA):
-Precautions for safe handling:
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Air sensitive.
*Storage class:
Storage class (TRGS 510): 13:
Non Combustible Solids



STABILITY and REACTIVITY of OCTADECYL AMINE (ODA):
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
OCTADECYLAMINE
octadecan-1-amine
124-30-1
1-Octadecanamine
Octadecanamine
Stearamine
Stearylamine
1-Aminooctadecane
1-Octadecylamine
n-Octadecylamine
Stearyl amine
n-Stearylamine
Armofilm
Armeen 18D
Monooctadecylamine
Nissan amine AB
Alamine 7
Noram SH
Alamine 7D
Oktadecylamin
Adogenen 142
Armeen 18
Armeen 118D
Amine AB
Farmin 80
Crodamine 1.18D
61788-45-2
Kemamine P990
Kemamine P 990
NSC 9857
Armid HTD
Armeen 1180
FFV58UNY7O
OCTADECANE,1-AMINO
Octadecylamineadogenen 142
CHEMBL55860
CHEBI:63866
NSC-9857
Octadecyl amine
CCRIS 4688
HSDB 1194
C18H39N
EINECS 204-695-3
UNII-FFV58UNY7O
BRN 0636111
AI3-14661
Steamfilm FG
1-octadecyl amine
EINECS 262-976-6
Octadecylamine, 97%
1-Octadecanamine, 9CI
STEARAMINE [INCI]
Amine 18-90
EC 204-695-3
EC 262-976-6
NCIOpen2_007744
SCHEMBL12291
OCTADECYLAMINE
4-04-00-00825 (Beilstein Handbook Reference)
SCHEMBL2159903
SCHEMBL3868686
SCHEMBL6253291
WLN: Z18
DTXSID1025801
Kemamine P-990, P-990D
NSC9857
Octadecylamine, >=99.0% (GC)
STR09001
BDBM50147579
MFCD00008159
STK062786
AKOS000269090
Octadecylamine, technical grade, 90%
CS-W012394
NCGC00164134-01
FT-0608174
FT-0659903
O0014
EN300-18141
D70506
A833419
J-005064
Q2013790
Z57204689
F3145-0795
InChI=1/C18H39N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h2-19H2,1H
1-Aminooctadecane, Stearylamine
OCTADECYLAMINE
STEARYLAMINE
OctadecyL
1-OCTADECYLAMINE
N-OCTADECYLAMINE
A18
1-Octadecanamine
Stearamine
EighteenaMine
FENTAMINE A18
1-Octadecanamine
Stearylamine
Octadecanamine
1-Aminooctadecane
n-Stearylamine
octadecan-1-amine
4-04-00-00825
Octadecylamine
1-Octadecylamine
n-Octadecylamine
UNII-FFV58UNY7O
EINECS 204-695-3
MFCD00008159
Octadecylaminetech
stearylamine approx. 90%
1-Octadedecylamine
1-Octadecylamine
1-Aminooctadecane
Stearylamine
Octadecylamin
octadecan-1-amine
A18
A 86
Octadecyl amine
Octadecanamine

OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE
SYNONYMS Octadecyl 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propionate;Hydrocinnamic acid, 3,5-di-tert-butyl-4-hydroxy-, octadecyl ester;3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid octadecyl ester;Octadecyl 3,5-di-t-butyl-4-hydroxyhydrocinnamate;W-107592;Octadecyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate CAS NO:2082-79-3
OCTADECYL-3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)PROPIONATE)
1-Aminooctadecane, Stearylamine, Octadecylamine; n-Stearylamine; 1-Octadecanamine; 1-Octadecylamine; Monooctadecylamine; n-Octadecylamine; CAS NO: 124-30-1
OCTADECYLAMINE
Octadecylamine is a primary alkyl amine mainly used as a hydrophobic surface modifier.
Octadecylamine is a chemical compound from the group of aliphatic amines.


CAS Number: 124-30-1
EC Number: 204-695-3
MDL number: MFCD00008159
Linear Formula: CH3(CH2)17NH2
Molecular Formula : C18H39N



1-Aminooctadecane, Stearylamine, OCTADECYLAMINE, octadecan-1-amine, 124-30-1, 1-Octadecanamine, Octadecanamine, Stearamine, Stearylamine, 1-Aminooctadecane, 1-Octadecylamine, n-Octadecylamine, Stearyl amine, n-Stearylamine, Armofilm, Armeen 18D, Monooctadecylamine, Nissan amine AB, Alamine 7, Noram SH, Alamine 7D, Oktadecylamin, Adogenen 142, Armeen 18, Armeen 118D, Amine AB, Farmin 80, Crodamine 1.18D, 61788-45-2, Kemamine P990, Kemamine P 990, NSC 9857, Armid HTD, Armeen 1180, FFV58UNY7O, OCTADECANE,1-AMINO, Octadecylamineadogenen 142, CHEMBL55860, CHEBI:63866, NSC-9857, Octadecyl amine, CCRIS 4688, HSDB 1194, C18H39N, EINECS 204-695-3, UNII-FFV58UNY7O, BRN 0636111, AI3-14661, Steamfilm FG, 1-octadecyl amine, EINECS 262-976-6, Octadecylamine, 97%, 1-Octadecanamine, 9CI, STEARAMINE [INCI], Amine 18-90, EC 204-695-3, EC 262-976-6, NCIOpen2_007744, SCHEMBL12291, OCTADECYLAMINE [HSDB], 4-04-00-00825 (Beilstein Handbook Reference), SCHEMBL2159903, SCHEMBL3868686, SCHEMBL6253291, WLN: Z18, DTXSID1025801, Kemamine P-990, P-990D, NSC9857, Octadecylamine, >=99.0% (GC), STR09001, BDBM50147579, MFCD00008159, AKOS000269090, Octadecylamine, technical grade, 90%, CS-W012394, NCGC00164134-01, FT-0608174, FT-0659903, O0014, EN300-18141, D70506, A833419, J-005064, Q2013790, Z57204689, F3145-0795, InChI=1/C18H39N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h2-19H2,1H, 1-Octadecanamine, Octadecylamine, Adogenen 142, Alamine 7, n-Octadecylamine, Stearylamine, n-Stearylamine, Alamine 7D, 1-Octadecylamine, Kemamine P 990, 1-Aminooctadecane, Armofilm, Armeen 18D, Nissan Amine AB, Stearamine, Crodamine 1.18D, Amine AB, Monooctadecylamine, Farmin 80, Armeen 18, ODA, Genamin SH 100, Kemamine P 990D, Amine 18D, Armeen 18D-FLK, NSC 9857, 18D, Lipomin 18D, Farmin 80S, Farmin 86V, Farmin 80V, Lipomin HTD, Stearylamine, 1-Aminooctadecane, 1-Octadecanamine, Stearylamine, Octadecanamine, 1-Aminooctadecane, n-Stearylamine, octadecan-1-amine, 4-04-00-00825, Octadecylamine, 1-Octadecylamine, n-Octadecylamine, UNII-FFV58UNY7O, EINECS 204-695-3, MFCD00008159, 1-Aminooctadecane, 1-Octadecanamine, 1-Octadecylamine, Monooctadecylamine, N-Octadecylamine, N-Stearylamine, Stearamine, Stearyl amine, Stearylamine, 1-Octadecanamine, 9ci, Adogenen 142, Alamine 7, Alamine 7D, Amine ab, Amines, hydrogenated tallow alkyl, Armeen 1180, Armeen 118D, Armeen 18, Armeen 18D, Armid HTD, Armofilm, Crodamine 1.18D, Farmin 80, Hydrogenated tallowamine, Kemamine p 990, Kemamine p-990, p-990D, Kemamine P990, Nissan amine ab, Noram SH, Octadecan-1-amine, OCTADECANE,1-amino, Octadecylamineadogenen 142, Oktadecylamin, Steamfilm FG, Tallow amine, hydrogenated, 1-Octadecanamine, hydrochloride, Octadecyl ammonium chloride, Stearylamine hydrochloride, Octadecylamine hydrochloride, 1-Octadecanamine, hydrochloride (1:1) Stearylammonium chloride, Octadecylamine, Octadecylamine, n-Octadecylamine, n-Stearylamine, Adogenen 142, Alamine 7, Alamine 7D, Armeen 18D, Armofilm, Kemamine P 990, Nissan amine AB, Noram SH, Stearamine, Stearylamine, 1-Aminooctadecane, Armeen 118d, Oktadecylamin, 1-Octadecylamine, Crodamine 1.18D, Amine AB, Monooctadecylamine, Farmin 80, Armeen 18, Oda, Amine 18-90, Armeen 1180, Armid HTD, Octadecylamineadogenen 142, NSC 9857 Octadecylaminetech, stearylamine approx. 90%, 1-Octadedecylamine, 1-Octadecylamine, 1-Aminooctadecane, Stearylamine, Octadecylamin, octadecan-1-amine, A18, A 86, Octadecyl amine, Octadecanamine,



Octadecylamine is soluble in chloroform, alcohol, ether, benzene and acetone.
Octadecylamine is insoluble in water.
Octadecylamine is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.


Octadecylamine, also known as N-stearylamine or 1-aminooctadecane, belongs to the class of organic compounds known as monoalkylamines.
These are organic compounds containing an primary aliphatic amine group.
Based on a literature review a significant number of articles have been published on Octadecylamine.


Octadecylamine belongs to the class of organic compounds known as monoalkylamines.
These are organic compounds containing an primary aliphatic amine group.
Octadecylamine is a chemical compound from the group of aliphatic amines.


Octadecylamine is a white odorless solid which is practically insoluble in water.
Octadecylamine appears as a white solid. Insoluble in water and less dense than water.
Octadecylamine hence floats on water.


Octadecylamine is an 18-carbon primary aliphatic amine.
Octadecylamine has a role as a film-forming compound.
Octadecylamine is an industrial-grade chemical compound reputed for its vast array of applications.


Frequently referred to as 1-Aminooctadecane or Stearylamine, Octadecylamine is distinguished by its CAS No. 124-30-1.
The chemical stands superior due to its remarkable properties and features, making Octadecylamine valuable for a wide variety of industrial sectors.



USES and APPLICATIONS of OCTADECYLAMINE:
Octadecylamine is used as asphalt emulsifier, lubricant and dispersants.
Octadecylamine acts as a cationic surfactant and find applications is hair rinse bases, wood preservatives, textile softeners, dyeing auxiliaries and pigment grinding aids.


Octadecylamine is used in boiler as an additive, which prevents the corrosion arises due to steam.
Octadecylamine is a basic building block and used as an intermediate in the preparation of their amine derivatives, ethoxylates and amides.
Octadecylamine is used to surface functionalize different carbon nanomaterials (graphene oxide, carbon nanotubes) for different applications which include thin film nanocomposite (TFN) nanofilteration and carbon fiber microelectrodes.


Octadecylamine can be used for the preparation of butyrylcholinesterase/stearylamine films (Langmuir-Blodgett films) for use in enzymatic field effect transistor (ENFET) based biosensors.
Octadecylamine also forms films which can be used in ion exachnge systems.


Octadecylamine may also be used in the preparation of metal oxide nano crystals with controlled size and shape.
Octadecylamine is used to grow nanocrystals
Octadecylamine is used as asphalt emulsifier, lubricant and dispersants.


Octadecylamine acts as a cationic surfactant and find applications is hair rinse bases, wood preservatives, textile softeners, dyeing auxiliaries and pigment grinding aids.
Octadecylamine is used in boiler as an additive, which prevents the corrosion arises due to steam.


Octadecylamine is mainly used to make octadecyl ammonium salt and a variety of additives, such as cationic grease thickener, mineral flotation agent, asphalt emulsifier, antistatic agent, corrosion inhibitor for water treatment, surfactants, chemical fertilizer anti-caking agent, fungicide, color film forming agent, etc.


Octadecylamine is used as a corrosion inhibitor in steam pipes and boilers.
Octadecylamine is used to grow nanocrystals.
Octadecylamine is used to make other chemicals.


Octadecylamine is a basic building block and used as an intermediate in the preparation of their amine derivatives, ethoxylates and amides.
Metal oxide nano crystals having controlled size and shape are prepared by the thermal decomposition of metal nitrates with Octadecylamine.
Octadecylamine is used as asphalt emulsifier, lubricant and dispersants.


Octadecylamine acts as a cationic surfactant and find applications is hair rinse bases, wood preservatives, textile softeners, dyeing auxiliaries and pigment grinding aids.
Octadecylamine is used in boiler as an additive, which prevents the corrosion arises due to steam.


Octadecylamine is a basic building block and used as an intermediate in the preparation of their amine derivatives, ethoxylates and amides.
Metal oxide nano crystals having controlled size and shape are prepared by the thermal decomposition of metal nitrates with octadecylamine.
Octadecylamine is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.


Octadecylamine is used the important intermediate of cationic and amphoteric surfactants ,widely used in mineral flotation agent,waterproof softener of fiber, dyeing assistant, anti-static agent, pigment dispersant, antirusting agents, anti-caking agent of fertilizer,bitumen emulsifier additives of lubricating oil,etc..


Octadecylamine is used as an intermediate in organic synthesis, used in the production of octadecane quaternary ammonium salt and various auxiliary agents, such as thickener for cationic grease, mineral processing agent, pesticide and asphalt emulsifier, fabric antistatic agent, softener, moisturizing agent Agents and water repellents, surfactants, fungicides, color formers for color films, and corrosion inhibitors for oil refining units.


Combining Octadecylamine and ethylene oxide in a molar ratio of 1:2 and reacting at 150-190°C, octadecyldiethanolamine [10213-78-2] can be obtained in a yield of nearly 80%.
Octadecyldiethanolamine is a non-ionic antistatic agent that can be used in polypropylene, polystyrene, and ABS resins.


Surfactant: Due to its amphiphilic character, Octadecylamine acts as an excellent surfactant aiding in emulsification and solubilization of various chemical mixtures.
Corrosion Inhibitor: Its unique properties enable Octadecylamine to work as an effective corrosion inhibitor, protecting metallic surfaces from degradation.


Emulsifier uses of Octadecylamine: Thanks to its capacity for stabilizing heterogeneous liquids, Octadecylamine is frequently used as an emulsifier, enhancing the quality and appearance of numerous products.
Lubricant Additive uses of Octadecylamine: When used in lubricants, Octadecylamine serves as an effective additive, reducing the friction between mechanical components and thus extending their operational lifespan.


-Flotation Agent uses of Octadecylamine:
In the mining industry, Octadecylamine is utilized as a flotation agent, separating valuable minerals from gangue during the ore beneficiation process.
Produced through meticulous processes, Octadecylamine ensures consistent quality and purity.
However, Octadecylamine is beneficial to follow the recommended safety precautions detailed in the corresponding Material Safety Data Sheet during handling and usage.



ALTERNATIVE PARENTS OF OCTADECYLAMINE:
*Organopnictogen compounds
*Hydrocarbon derivatives



SUBSTITUENTS OF OCTADECYLAMINE:
*Organopnictogen compound
*Hydrocarbon derivative
*Primary aliphatic amine
*Aliphatic acyclic compound




RECOGNIZABLE BY MULTIPLE NAMES OF OCTADECYLAMINE:
Aside from its common name, Octadecylamine is known in various scientific realms under the aliases of 1-Aminooctadecane and Stearylamine.



STRUCTURAL CLARITY OF OCTADECYLAMINE:
The linear formula CH3(CH2)17NH2 offers a precise image of the compound's structural composition: a stearyl chain bonded to an amino group.



NAVIGABLE IDENTIFICATION OF OCTADECYLAMINE:
The distinct CAS No. 124-30-1 simplifies Octadecylamine's identification and cataloging in chemical databases.
The versatile applications of Octadecylamine are reflected in several industrial uses, including.



PHYSICAL and CHEMICAL PROPERTIES of OCTADECYLAMINE:
CAS Number: 124-30-1
Molecular Weight: 269.51
Beilstein: 636111
EC Number: 204-695-3
MDL number: MFCD00008159
Physical state: powder
Color: white
Odor: amine-like
Melting point/freezing point:
Melting point/range: 50 - 52 °C - lit.
Initial boiling point and boiling range: 232 °C at 43 hPa - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 148 °C - closed cup
Autoignition temperature: No data available

Decomposition temperature: No data available
pH: 11,4 at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility 0,001 g/l - insoluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 0,00 hPa at 20 °C
Density: 0,94 g/cm3 at 23,2 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not explosive
Oxidizing properties: No data available
Other safety information: No data available

Molecular Weight: 269.5 g/mol
XLogP3: 8.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 16
Exact Mass: 269.308250248 g/mol
Monoisotopic Mass: 269.308250248 g/mol
Topological Polar Surface Area: 26Ų
Heavy Atom Count: 19
Formal Charge: 0
Complexity: 145
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

CAS number: 124-30-1
EC index number: 612-282-00-8
EC number: 204-695-3
Hill Formula: C₁₈H₃₉N
Molar Mass: 269.52 g/mol
HS Code: 2921 19 99
Boiling point: 132 °C (43 hPa)
Density: 0.94 g/cm3 (23.2 °C)
Flash point: 148 °C
Melting Point: 50 - 52 °C
pH value: 11.4 (H₂O, 20 °C)
Vapor pressure: 0.21 Pa (20 °C)

Melting Point: 50-60ºC
Boiling Point: 348.9±5.0 °C at 760 mmHg
Flash Point: 154.1±13.6 °C
Molecular Formula: C18H39N
Molecular Weight: 269.509
Density: 0.8±0.1 g/cm3
Chemical Formula: C18H39N
Average Molecular Weight: 269.509
Monoisotopic Molecular Weight: 269.308250253
IUPAC Name: octadecan-1-amine
Traditional Name: octadecylamine
CAS Registry Number: 124-30-1
SMILES: CCCCCCCCCCCCCCCCCCN
InChI Identifier: InChI=1S/C18H39N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h2-19H2,1H3
InChI Key: REYJJPSVUYRZGE-UHFFFAOYSA-N

Formula: H₃C(CH₂)₁₆CH₂NH₂
MW: 269,51 g/mol
Boiling Pt: 349 °C (1013 hPa)
Melting Pt: 50…52 °C
Density: 0,8618 g/cm³ (20 °C)
Flash Pt: 110 °C
Storage Temperature: Ambient
MDL Number: MFCD00008159
CAS Number: 124-30-1
EINECS: 204-695-3
UN: 3077
ADR: 9,III
Solubility: (20 °C) practically insoluble
Melting Point: 50 - 52 °C
Molar Mass: 269.51 g/mol
Boiling Point: 349 °C
Vapor Pressure: - 100 hPa (20 °C)
Flash Point: 110 °C
Density: 0.86 g/cm3 (20 °C)

Molecular Formula / Molecular Weight: C20H43N = 297.57
Physical State (20 deg.C): Solid
Storage Temperature: 0-10°C
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Air Sensitive
CAS RN: 124-28-7
Reaxys Registry Number: 1763346
PubChem Substance ID: 87568090
SDBS (AIST Spectral DB): 17241
MDL Number: MFCD00048496
Molecular Formula / Molecular Weight: C18H39N = 269.52
Physical State (20 deg.C): Solid
CAS RN: 124-30-1
Reaxys Registry Number: 636111
PubChem Substance ID: 87574032
SDBS (AIST Spectral DB): 1639
MDL Number: MFCD00008159



FIRST AID MEASURES of OCTADECYLAMINE:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Do NOT induce vomiting.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of OCTADECYLAMINE:
-Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
-Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of OCTADECYLAMINE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available


EXPOSURE CONTROLS/PERSONAL PROTECTION of OCTADECYLAMINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Face shield and safety glasses.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Complete suit protecting against chemicals.
-Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.



HANDLING and STORAGE of OCTADECYLAMINE:
-Precautions for safe handling:
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Sensitive to carbon dioxide Handle and store under inert gas.
Air sensitive.
*Storage class:
Storage class (TRGS 510): 13:
Non Combustible Solids



STABILITY and REACTIVITY of OCTADECYLAMINE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available





Octadecylamine (ODA)
1-Aminooctadecane, Stearylamine, Octadecylamine; n-Stearylamine; 1-Octadecanamine; 1-Octadecylamine; Monooctadecylamine; n-Octadecylamine; CAS NO: 124-30-1
OCTANEDIOL
CETYL CAPRYLATE, N° CAS : 29710-31-4, Nom INCI : CETYL CAPRYLATE, Nom chimique : Hexadecyl octanoate, N° EINECS/ELINCS : 249-794-2, Emollient : Adoucit et assouplit la peau;Agent d'entretien de la peau : Maintient la peau en bon état. Hexadecyl octanoate. 249-794-2 [EINECS]; 29710-31-4 [RN]; CETYL CAPRYLATE; Octanoate de pentadécyle [French] ; Octanoic acid, pentadecyl ester [ACD/Index Name]; Pentadecyl octanoate ; Pentadecyl-octanoat [German] ; caprylic acid pentadecyl ester; Caprylic acid, cetyl ester; Caprylic acid, cetyl ester; Cetyl caprylate; Cetyl octanoate; Hexadecyl caprylate; Hexadecyl N-octanoate; Cetyl octanoate; Hexadecyl caprylate; Hexadecyl N-octanoate; Hexadecyl octanoate ; octanoic acid pentadecyl ester
Octanoate de pentadécyle ( CETYL CAPRYLATE)
SYNONYMS C-8 Acid; Neo-fat 8; n-Caprylic Acid; Capryloate; Octoic acid; Octic acid; 1-Heptanecarboxylic acid; n-Octanoic Acid; n-Octic acid; n-Octylic acid; Octanoic Acid; CAS NO. 124-07-2
OCTANOIC ACID
Octanoic acid, also known as potassium iso-octanoate, is a chemical used to convert the tert-butylammmonium salt of clavulanic acid into potassium clavulanate (clavulanate potassium).
Octanoic acid is a Potassium source that is soluble in organic solvents.
Octanoic acid is one of numerous organo-metallic compounds sold for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications.

CAS Number:764-71-6
EC Number: 212-130-7
Molecular Formula: C8H17KO2
Molecular Weight: 184.32

Octanoic acid is a salt of caproic acid and potassium that is used as a food additive.
Octanoic acid can be used to prevent the development of rancidity in oils made with unsaturated fatty acids.
Octanoic acid has also been shown to have beneficial effects on the heart, such as slowing the heart rate and reducing arrhythmias.

Octanoic acid has been shown to have physiological effects in humans, including lowering serum cholesterol and triglycerides levels.
Octanoic acid has also been shown to reduce inflammation by inhibiting prostaglandin synthesis.

Octanoic acid when combined with cobalt support the accelerating effect in unsaturated polyesters.
This results in a decrease of discoloration of UPS-Systems caused by Cobalt.
Further Octanoic acid is also capable of stabilizing the rheological and the pot life behavior of waterborne 2- components PUR systems and additionally Octanoic acid can positively affect the haze-values of these paint systems.

Octanoic acid, also known as potassium iso-octanoate, is a chemical used to convert the tert-butylammmonium salt of clavulanic acid into potassium clavulanate (clavulanate potassium).
Octanoic acid is also used as a corrosion inhibitor in automotive antifreeze and as a catalyst for polyurethane systems.

Octanoic acid is an organic compound of four elements: Carbon, Hydrogen, Potassium, and Oxygen.
The molecular weight of Octanoic acid is 182.3027 which can be calculated by adding up the total weight (atomic weight multiplied by their number) of Carbon, Hydrogen, Potassium, and Oxygen.

To calculate molecular weight of any compound, the first step is to know the constituent elements (atoms) and their number in that particular compound.
Then calculate the total atomic weight of each element by multiplying Octanoic acid atomic weight by Octanoic acid number.

The sum of total atomic weight of all constituent elements will be the molecular weight of Octanoic acid.
Note that the value of atomic weight may differ from different sources.

Octanoic acid is a Potassium source that is soluble in organic solvents.
Ethylhexanoates are carboxylates with many commercial applications.
They are commonly used in various catalysts for oxidation, hydrogenation and polymerization and as an adhesion promoter.

Octanoic acid is one of numerous organo-metallic compounds sold for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications.
Similar results can sometimes also be achieved with Nanoparticles and by thin film deposition.

Octanoic acid is otherwise known as potassium 2-ethylhexanoate.
Octanoic acid appears as a water white to clear, pale yellow liquid.

Octanoic acid can be used to promote cobalt soap catalysis and to reduce the dosage of cobalt during the polymerization of polyester resin paint.
The end product will become a light-colored polyester resin.

Octanoic acid is standard grade potassium-based metal carboxylate with 15% K, diluted in diethylene glycol.
Octanoic acid is used as co-catalyst to boost cobalt performance and reduce color in unsaturated polyester resins and gelcoats.

Further, Octanoic acid is also used as liquid trimerization catalyst for polyisocyanurate (PIR) foam.
Catalyst ensures a highly cross-linked polyisocyanurate foam structure, resulting in strong and durable insulation products.

Octanoic acid is a salt of caproic acid and potassium that is used as a food additive.
Octanoic acid can be used to prevent the development of rancidity in oils made with unsaturated fatty acids.

Octanoic acid is used to convert the tert-butylammmonium salt of clavulanic acid into potassium clavulanate or clavulanate potassium.
Octanoic acid is also used as a catalyst for polyurethane systems (foams) and for unsaturated polyester resin systems.

Octanoic acid is diethylene glycol solution mainly used as a trimerized catalyst for polyurethanes.
Octanoic acid offers strong catalysing properties, is odorless, reduces the 'demoulding' time in foams and promotes the 'cross-linking' and 'cure' process.
Octanoic acid is soluble in water, alcohol and other polar solvents.

Octanoic acid is an effective promoter with cobalt octoate used in low color applications.
Octanoic acid is soluble in organic solvents and oils, and Octanoic acid has a potassium metal content of 15% and a total solids content of 80%.

Octanoic acid is a potassium catalyst and is widely used in rigid isocyanate foam reaction.
Octanoic acid is an excellent and cost-effective isocyanate catalyst.
Because of Octanoic acid high conversion rate, Octanoic acid has become a catalyst for many rigid foams.

Octanoic acid exhibits solubility in numerous organic solvents.
Octanoic acid applications span a wide range of fields, serving as a catalyst in organic synthesis, an electrolyte in batteries, and an additive in lubricants and adhesives.

Moreover, Octanoic acid finds utility in polymer and plastic production.
In laboratory settings, Octanoic acid proves invaluable for a diverse array of chemical reactions, encompassing polymer synthesis and catalyst preparation.

An excellent candidate to consider for manufacturing polyisocyanurate rigid foam, Octanoic acid may be used in formulated systems or by direct metering.
Octanoic acid also can improve the foam isotropy for more dimensional stability and compressive strength.

Octanoic acid offers several advantages compared to other Niax catalyst K-Zero G additive catalysts.
In addition to minimizing the amount of isocyanate consumed, Octanoic acid also has a lower viscosity than typical Octanoic acid in DEG, which can improve both pumping and handling.

Octanoic acid has no odor and is not classified as flammable.
Octanoic acid also offers better formulation flexibility with Octanoic acid ability to raise the NCO index at a constant isocyanate-to-polyol rate.

Octanoic acid typically requires the same dosage level as the commonly used Niax catalyst K-Zero G additives it may replace.
In addition, Octanoic acid water content is essentially identical to the typical Niax catalyst K-Zero G additives, so MDI consumption is not significant.

Octanoic acid is a salt of caproic acid and potassium that is used as a food additive.
Octanoic acid can be used to prevent the development of rancidity in oils made with unsaturated fatty acids.
Octanoic acid has also been shown to have beneficial effects on the heart, such as slowing the heart rate and reducing arrhythmias.

Octanoic acid has been shown to have physiological effects in humans, including lowering serum cholesterol and triglycerides levels.
Octanoic acid has also been shown to reduce inflammation by inhibiting prostaglandin synthesis.

Octanoic acid Market Analysis:
Global Octanoic acid Market Report 2023 talks about crucial market insights with the help of segments and sub-segments analysis.
In this section, we reveal an in-depth analysis of the key factors influencing Octanoic acid Industry growth.

Octanoic acid market has been segmented with the help of Octanoic acid Type, Application , and others.
Octanoic acid market analysis helps to understand key industry segments, and their global, regional, and country-level insights.

Furthermore, this analysis also provides information pertaining to segments that are going to be most lucrative in the near future and their expected growth rate and future market opportunities.
The report also provides detailed insights into factors responsible for the positive or negative growth of each industry segment.

Type Segment Analysis of Octanoic acid Market:
Quality management is the major parameter to meet specific standards and specifications, reliability and consistency.
The chemical and material industry is full of various types of chemicals and Octanoic acid is necessary to focus on quality management because Octanoic acid may affect environment & other equipment.

Raw materials plays an important role in this industry.
The chemical industry converts these raw materials into primary, secondary, and tertiary products.

Fluctuations in raw material prices may impact the market growth in the near future.
This study includes the revenue generation of each type in each region for the year 2018 to 2030.
Additionally Octanoic acid also provides detailed supply chain analysis along with current trends in the market which are expected to propel the market growth in the coming year.

Application Segment Analysis of Octanoic acid Market:
Chemical and materials are one of the most important industries for other sectors including automotive, pharmaceutical, personal care, consumer goods and others.
The demand for high quality and environment friendly products is increasing in various end-use sectors.

Thus, key manufacturers are focusing on technological advancement in production of high-quality chemicals.
The segment analysis will help to understand which is the most attractive application/end use sector.

Octanoic acid also provides the year on year (Y-O-Y) growth rate for each segment.
Moreover, this study includes the detailed analysis of each segment to understand the key positive and negative factors which are impacting the growth of the Octanoic acid Market.

Some of the key Application of Octanoic acid are:
Dryer
Resin Catalyst
Fragrance & Flavor
Other

Applications of Octanoic acid:

Catalyst:
Octanoic acid is co-catalyst to boost cobalt performance in unsaturated polyester resins and gelcoats.
Octanoic acid is trimerization catalyst for polyisocyanurate foam.

Uses of Octanoic acid:
Octanoic acid can be used to promote cobalt soap catalysis and to reduce the dosage of cobalt during the polymerization of polyester resin paint.
Octanoic acid is used as co-catalyst to boost cobalt performance and reduce color in unsaturated polyester resins and gelcoats.

Industry Uses:
Cleaning agent
Corrosion inhibitor
Drier
Lubricating agent
Surface modifier
Surfactant (surface active agent)

Consumer Use:
Drier

Usage of Octanoic acid:
Octanoic acid is mainly used as salt-forming agent of potassium clavulanate, salt-forming agent of synthesizing cephalosporin antibiotics, cross-linking agent of macromolecule materials, heat stabilizer of plastic products, catalyst of polymerization, additive of lubricating oil and fuel oil, and can also be used in the fields of dyestuff, perfume and preservative.
Octanoic acid is mainly used as a salt forming agent for the synthesis of cephalosporin antibiotic potassium clavulanate, a heat stabilizer for plastic products, a catalyst for polymerization, and a crosslinking agent for polymer materials.

General Manufacturing Information of Octanoic acid:

Industry Processing Sectors:
Fabricated Metal Product Manufacturing
Paint and Coating Manufacturing
Soap, Cleaning Compound, and Toilet Preparation Manufacturing

Handling and Storage of Octanoic acid:
The use of Octanoic acid requires technical and professional knowledge.
For further information on handling, storage and toxicity consult the safety data sheet.
Octanoic acid must always be stored sealed, in a cool, ventilated place, protected from atmospheric agents.

Packaging:
The standard packaging of Octanoic acid is in 1000 kg IBCs.

Stability and Reactivity of Octanoic acid:

Chemical stability:

Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.

Incompatible materials:
No further relevant information available.

Hazardous decomposition products:
No dangerous decomposition products known.

Safety of Octanoic acid:

H Statements:

H315:
Causes skin irritation.

H319:
Causes serious eye irritation.

H335:
May cause respiratory irritation.

P Statements:

P158:
P158

P261:
Avoid breathing dust, fumes, gas, mist, vapours, spray.

P280:
Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:

IF ON SKIN:
Wash with plenty of soap and water.

P304+P340:

IF INHALED:
Remove person to fresh air and keep comfortable for breathing.

P305+P351+P338:

IF IN EYES:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do.
Continue rinsing.

P403+P233:
Store in a well ventilated place.
Keep container tightly closed.

P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.

Fire Fighting Procedures of Octanoic acid:

If material on fire or involved in fire:
Use water in flooding quantities as fog.
Solid streams of water may be ineffective.

Cool all affected containers with flooding quantities of water.
Apply water from as far a distance as possible.
Use "alcohol" foam, dry chemical or carbon dioxide. Use water spray to knock-down vapors.

Cleanup Methods of Octanoic acid:

Environmental considerations:

Land spill:
Dig a pit, pond, lagoon, holding area to contain liquid or solid material.
If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner.

Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete.
Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3).
Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Water spill:
Use natural barriers or oil spill control booms to limit spill travel.
Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3).
Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Air spill:
Apply water spray or mist to knock down vapors.
Vapor knockdown water is corrosive or toxic and should be diked for containment.

ENVIRONMENTAL HAZARDS (5 gallons or greater):
Do not discharge effluent containing Octanoic acid into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollutant Discharge Elimination System (NPDES) permit and permitting authority has been notified in writing prior to discharge.
Do not discharge effluent containing Octanoic acid to sewer systems without previously notifying the local sewage treatment plant authority.

Disposal Methods of Octanoic acid:
The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination.
Recycle any unused portion of Octanoic acid for Octanoic acid approved use or return Octanoic acid to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
Octanoic acid's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

For containers less than 1 gallon:
Do not reuse container.
Wrap container and discard in the trash. (1 gal. bladder in box) Remove empty bladder from outer corrugated box.
Do not reuse bladder. Wrap bladder and box and put in trash.

Pesticide Disposal:
Pesticide wastes are acutely hazardous.
Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal Law.
If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste Representative at the nearest EPA Regional Office for guidance.

Container Disposal:
Triple rinse (or equivalent).
Then offer for recycling or reconditioning, or puncture and dispose of in sanitary landfill, or incineration, or if allowed by state and local authorities, by burning.

If burned, stay out of smoke:
Remove empty bladder from outer corrugated box.
Triple rinse bladder (or equivalent).
Offer box and bladder for recycling or dispose of in a sanitary landfill or incineraVon, or if allowed by state and local authorities, by burning.

Identifiers of Octanoic acid:
EC / List no.: 212-130-7
CAS no.: 764-71-6
Mol. formula: C8H16O2.K

CAS No.: 764-71-6
Chemical Name: Octanoic acid
CBNumber: CB9106938
Molecular Formula: C8H17KO2
Molecular Weight: 184.32
MDL Number: MFCD00801112
MOL File: 764-71-6.mol

Formula: C8H15KO2
InChI: InChI=1S/C8H16O2.K/c1-2-3-4-5-6-7-8(9)10;/h2-7H2,1H3,(H,9,10);
InChI key: InChIKey=NEDCBCQYSIPIMC-UHFFFAOYSA-N
SMILES: [K].O=C(O)CCCCCCC

Product Name: Octanoic acid
CAS: 764-71-6
EICNECS: 212-130-7
Formula: C8H15KO2
Synonyms: Potassium Octanoate, Octanoic acid, Potassium Salt (1:1)
Suggested Industries: Construction & Building Materials

IUPAC Traditional: potassium octanoate
Molecular formula: C8H15KO2
Molecular weight: 182.304
SMILES: [K+].CCCCCCCC([O-])=O
Compound number: Molport-006-112-319

Linear Formula: K[OOCCH(C2H5)C4H9]
MDL Number: MFCD00045896
EC No.: 221-625-7
Beilstein/Reaxys No.: N/A
Pubchem CID: 23669619
IUPAC Name: potassium 2-ethylhexanoate
SMILES: [K+].[O-]C(=O)C(CC)CCCC
InchI Identifier: InChI=1S/C8H16O2.K/c1-3-5-6-7(4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InchI Key: ZUFQCVZBBNZMKD-UHFFFAOYSA-M

CAS Number: 3164-85-0
ChemSpider: 56266
ECHA InfoCard: 100.019.660
EC Number: 221-625-7
PubChem CID: 62486
UNII: P089X9A38X
CompTox Dashboard (EPA): DTXSID4027525
InChI: InChI=1S/C8H16O2.K/c1-3-5-6-7(4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
Key: ZUFQCVZBBNZMKD-UHFFFAOYSA-M
InChI=1/C8H16O2.K/c1-3-5-6-7(4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
Key: ZUFQCVZBBNZMKD-REWHXWOFAE
SMILES: [K+].[O-]C(=O)C(CC)CCCC

Properties of Octanoic acid:
Chemical formula: C8H15KO2
Molar mass: 182.304 g·mol−1

Molecular weight: 183.31 g/mol
Formula: C8H16O2•K
Purity: Min. 95%
Color/Form: Powder
MDL: MFCD00801112
HS code: 2915907098

Appearance: Liquid
Color Clear: Yellow
Content of Octanoic acid, % 75: ± 3
Viscosity @ 25°C, mPa s: 3500 - 4500
OH number, mg KOH / g (calculated): 470
Water content, %: 3.2 - 3.7

Molecular Weight: 182.30 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 6
Exact Mass: 182.07091120 g/mol
Monoisotopic Mass: 182.07091120 g/mol
Topological Polar Surface Area: 40.1Ų
Heavy Atom Count: 11
Complexity: 94.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Specifications of Octanoic acid:
Appearance: Liquid
Color: Yellow-orange
Metal Content: 15% potassium
Solvent: Diethylene glycol
Typical Viscosity (mPa.s, rt): 5 000
Viscosity 25°C (dPa.s): 50,5
Water Content (wt %): 4
Concentration (wt %): 71
OH Value (mg KOH/g): 254

Color: White
Quantity: 25 g
Formula Weight: 182.30
Percent Purity: ≥95.0% (T)
Physical Form: Crystalline Lumps
Chemical Name or Material: Potassium 2-Ethylhexanoate

Complementary Products of Octanoic acid:

Similar products that may enhance results or work well together:
Niax Silicone L-6633
Niax Catalyst A-1
Niax Catalyst C-41

Names of Octanoic acid:

Regulatory process names:
Caprylic acid, potassium salt
Octanoic acid, potassium salt
Octanoic acid, potassium salt (1:1)
Potassium caprylate
Potassium octanoate
Potassium octanoate
potassium octanoate

IUPAC names:
Octanoic acid, potassium salt
potassium caprylate ou octanoate
Potassium octanoate
potassium octanoate
potassium octanoic acid
Potassium Octoate
potassium;octanoate
Potassium 2-ethylhexanoate

Other identifiers:
146837-11-8
764-71-6

Synonyms of Octanoic acid:
Potassium octanoate
764-71-6
Potassium caprylate
Potassium octoate
potassium;octanoate
EINECS 212-130-7
Octanoic acid, potassium salt (1:1)
UNII-7CND0TX59N
7CND0TX59N
Caprylic acid, potassium salt
OCTANOIC ACID, POTASSIUM SALT
potassium n-octanoate
potassium octylate
SCHEMBL26223
CHEMBL3894810
DTXSID9052507
POTASSIUM CAPRYLATE [INCI]
CAPRYLIC ACID POTASSIUM SALT
EC 686
AKOS006220435
K 977
Q27268087
221-625-7 [EINECS]
2-Éthylhexanoate de potassium [French] [ACD/IUPAC Name]
2-Ethylhexanoic acid, potassium salt
3164-85-0 [RN]
Hexanoic acid, 2-ethyl-, potassium salt
Hexanoic acid, 2-ethyl-, potassium salt (1:1) [ACD/Index Name]
Kalium-2-ethylhexanoat [German] [ACD/IUPAC Name]
Potassium 2-ethylhexanoate [ACD/IUPAC Name]
[3164-85-0] [RN]
19766-89-3 [RN]
2-ETHYLHEXANOIC ACID POTASSIUM SALT
2-ETHYLHEXANOIC ACID POTASSIUM SALT, ANHYDROUS
764-71-6 [RN]
93357-97-2 [RN]
MFCD00045896 [MDL number]
MFCD00801112
Potassium 2-ethyl hexanoate
potassium and 2-ethylhexanoate
Potassium octoate
Potassium octoate/Potassium acetate
potassium2-ethylhexanoate
POTASSIUM-2-ETHYLHEXANOATE
POTASSIUMOCTOATE
OCTANOIC ACID
Octanoic acid has a mildly unpleasant odor and a burning, rancid taste.
Octanoic acid is also reported as having a faint, fruity–acid odor and slightly sour taste.
Octanoic acid appears as a colorless to light yellow liquid with a mild odor.

CAS Number: 124-07-2
Molecular Formula: C8H16O2
Molecular Weight: 144.21
EINECS Number: 204-677-5

As an eight-carbon compound, octanoic acid is among the fatty acids considered to be of short or medium chain length.
Burns, but may be difficult to ignite.
Octanoic acid, corrosive to metals and tissue.

Octanoic acid, CH3(CH2)6COOH, also known as hexylacetic acid,n-octanoic acid, octylie acid, and octic acid, is a colorless, oily liquid having a mildly unpleasant odor and a burning, rancid taste.
Octanoic acid is only slightly soluble in water (68 mg per 100 mL at 20°C).
Octanoic acid is a natural component of coconut and palm nut oils and butter fat.

Octanoic acid has also been identified in trace amounts in beer, brandy distillate, the essential oil of fermented Russian black tea leaves, and raw soybeans.
Octanoic acid is used in manufacturing drugs and dyes.

Octanoic acid (from Latin capra 'goat'), also known under the systematic name octanoic acid or C8 Acid, is a saturated fatty acid, medium-chain fatty acid (MCFA).
Octanoic acid has the structural formula H3C−(CH2)6−COOH, and is a colorless oily liquid that is minimally soluble in water with a slightly unpleasant rancid-like smell and taste.
Salts and esters of octanoic acid are known as octanoates or caprylates.

Octanoic acid is a common industrial chemical, which is produced by oxidation of the C8 aldehyde.
Octanoic acids compounds are found naturally in the milk of various mammals and as a minor constituent of coconut oil and palm kernel oil.
Octanoic acid is an eight carbon fatty acid, which is found in palm, coconut oil and milk.

Octanoic acid is used to treat candidiasis and bacterial infections. Octanoic acid has antibacterial and antifungal properties.
Octanoic acid is used in nutritional supplementation.
Octanoic acid is the common name for the eight-carbon straight-chain fatty acid known by the systematic name octanoic acid.

Octanoic acid is found naturally in coconuts and breast milk. It is an oily liquid with a slightly unpleasant rancid taste that is minimally soluble in water.
Octanoic acid is used commercially in the production of esters used in perfumery and also in the manufacture of dyes (Wikipedia ).
Octanoic acid can be found in numerous foods such as Prunus (Cherry, Plum), pineapple sages, black raspberries, and shallots.

Octanoic acid is found to be associated with medium-chain acyl-CoA dehydrogenase deficiency, which is an inborn error of metabolism.
Octanoic acid is used in the production of esters, which finds application in perfumery and also dyes manufacture.
Octanoic acid is used as a food contact surface sanitizer in commercial food handling, as a dietary supplement and as disinfectant in health care facilities, recreational facilities, livestock premises and industrial facilities.

Octanoic acid chloride is used in the synthesis of perfluorooctanoic acid.
Octanoic acid, also known as Octanoic acid, is a naturally occurring compound found in the milk of various mammals and present as a minor component in coconut oil and palm kernel oil.
As a straight-chain saturated fatty acid with eight carbon atoms, it takes the form of a white, waxy solid with a distinctive odor.

Octanoic acid possesses antimicrobial, pesticidal, algaecidal, bactericidal, and fungicidal properties.
Octanoic acid is widely distributed in animal fats and oils. This versatile compound plays a crucial role in the synthesis of various compounds and finds applications in both in vivo and in vitro research settings.
Octanoic acid exhibits its effects through multiple mechanisms.

Octanoic acid can hinder triglyceride synthesis, resulting in decreased levels of circulating free fatty acids.
Additionally, Octanoic acid influences the activity of enzymes like lipoprotein lipase and acyl-CoA synthetase.
Moreover, octanoic acid modulates the activity of transcription factors including NF-kB and AP-1.

Octanoic acid impacts several biochemical and physiological processes, affecting enzymes, transcription factors, and gene expression involved in apoptosis, cell proliferation, and inflammation.
Octanoic acid, also known as Octanoic acid, is a saturated fatty acid with the chemical formula C8H16O2.
Octanoic acid is a carboxylic acid, which means it has a carboxyl group (–COOH) at one end of its molecular structure.

Octanoic acid is classified as a medium-chain fatty acid due to its relatively short carbon chain length.
Two other acids are named after goats via the Latin word capra: caproic acid (C6) and Octanoic acid (C10).
Together, these three fatty acids comprise 15% of the fatty acids in goat milk fat.

Octanoic acid is a straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group.
Octanoic acid is also known as Octanoic acid.
Octanoic acid has a role as an antibacterial agent, a human metabolite and an Escherichia coli metabolite.

Octanoic acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
Octanoic acid is a conjugate acid of an octanoate.
Octanoic acid is found naturally in the milk of various mammals, and it is a minor constituent of coconut oil and palm kernel oil.

Octanoic acid has also been identified in trace amounts in beer, brandy distillate, the essential oil of fermented Russian black tea leaves and raw soybeans.
Octanoic acid reacts exothermically to neutralize bases.
Can react with active metals to form gaseous hydrogen and a metal salt.

Octanoic acid may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers.
Reacts with cyanide salts or solutions of cyanide salts to generate gaseous hydrogen cyanide.
Reacts exothermically with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases.

Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.
Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide) but still heat.

Can be oxidized exothermically by strong oxidizing agents and reduced by strong reducing agents.
A wide variety of products is possible.
Octanoic acid may initiate polymerization reactions or catalyze (increase the rate of) reactions among other materials.

Melting point: 16 °C
Boiling point:237 °C(lit.)
Density: 0.91 g/mL at 25 °C(lit.)
vapor density: 5 (vs air)
vapor pressure: 1 mm Hg ( 78 °C)
refractive index: n20/D 1.428(lit.)
FEMA: 2799 | OCTANOIC ACID
Flash point: >230 °F
storage temp.: 20-25°C
solubility: 0.68g/l
pka: 4.89(at 25℃)
form: Liquid
Specific Gravity: 0.910 (20/4℃)
color: Clear colorless to yellow
PH: 3.97(1 mM solution);3.45(10 mM solution);2.95(100 mM solution);
Odor: unpleasant odor
PH Range: 3.5
Odor Type: fatty
Viscosity: 6.6mm2/s
explosive limit: 1%(V)
Water Solubility: 0.68 g/L (20 ºC)
Merck: 14,1765
JECFA Number: 99
BRN: 1747180
Stability: Stable. Incompatible with bases, reducing agents, oxidizing agents. Flammable.
LogP: 3.05 at 20℃

Octanoic acid and its derivatives are used as components in lubricants and greases, especially in high-temperature applications.
They can help reduce friction and wear on mechanical components.
Octanoic acid esters, such as octyl acetate, are used as plasticizers in the production of plastics and polymers.

Octanoic acid improve the flexibility and durability of plastic materials.
In the manufacturing of polyurethane foams, octanoic acid can be used as a foaming agent to produce foam products like cushions and insulation materials.
Octanoic acid is sometimes employed in the leather industry for tanning and as a component in leather finishing agents.

Octanoic acid can be used as a feedstock in the production of biodiesel, a renewable alternative to traditional diesel fuel.
Octanoic acid is used in laboratory and research settings for various applications, including the study of lipid metabolism and microbial growth.

Octanoic acid and its salts can be used as flotation agents to separate valuable minerals from ore.
Some derivatives of octanoic acid are used as flame retardants in plastics and textiles to improve fire resistance.
Octanoic acid can be used in metal cleaning solutions to remove grease, oil, and other contaminants from metal surfaces.

Octanoic acid can be used in the production of adhesives and sealants, contributing to their adhesive properties.
Octanoic acid is a versatile chemical intermediate, serving as a starting point for the synthesis of various compounds used in different industries.
Octanoic acid is used in the flavor and fragrance industry to create specific scents and flavors, particularly those with creamy or buttery notes.

Octanoic acid is a key component in the production of artificial flavorings and fragrances.
Octanoic acid and its derivatives can be used in agriculture as pesticide synergists or as components of pesticide formulations to enhance their effectiveness in pest control.
Octanoic acid is used in animal feed formulations as a nutritional supplement.

Octanoic acid can be a source of energy for livestock and poultry and may contribute to better animal health.
Octanoic acid can be used in the production of biodegradable products, such as biodegradable plastics, which are environmentally friendly alternatives to traditional plastics.

Octanoic acid can be found in drilling fluids used in the oil and gas industry.
Octanoic acid helps control the viscosity of these fluids and assists in drilling operations.
Octanoic acid is used in wastewater treatment processes to help control odors and reduce the growth of algae and other microorganisms in water treatment facilities.

Octanoic acid and its salts can be used in cleaning and disinfection products for their antimicrobial properties.
In analytical chemistry, octanoic acid can be used as a reference material and as a standard for certain chemical analyses.
Octanoic acid can be employed as a corrosion inhibitor in various applications to protect metal surfaces from rust and corrosion.

In the automotive and aviation industries, octanoic acid and its derivatives can be used as fuel additives to improve combustion and reduce engine knocking.
Octanoic acid and its derivatives are used in biomedical research for various purposes, including cell culture, drug delivery systems, and as components in certain diagnostic reagents.

Octanoic acid can be used in the production of biofuels, such as biojet fuels, which are sustainable alternatives to conventional aviation fuels.
Octanoic acid can be used in the formulation of surface coatings, including paints and protective coatings, to enhance their adhesion and durability.
Some octanoic acid derivatives are used in the photographic industry as components of developer solutions for film and photographic paper.

Octanoic acid esters can be found in detergents and household cleaners, where they function as surfactants and emulsifying agents for effective cleaning.
Octanoic acid can be used as a component in animal repellent formulations to deter wildlife and pests from certain areas.
Octanoic acid is used in the control and prevention of biofilm formation in industrial and healthcare settings, where biofilms can lead to equipment fouling and infections.

In the electronics industry, octanoic acid can be used in the cleaning of electronic components and in the manufacturing of printed circuit boards.
Octanoic acid derivatives can be used to formulate emulsifiable concentrates (ECs) for agricultural pesticides, improving their dispersibility and effectiveness.
Octanoic acid can be used in the production of waxes and polishes for applications such as furniture, automotive, and floor care.

Certain octanoic acid derivatives can serve as fixatives in perfumes and fragrances, helping to prolong the scent's longevity.
Octanoic acid esters can be used in the production of construction materials, such as sealants and adhesives, to enhance their performance and durability.
Octanoic acid is used in some firefighting foams to create a stable foam blanket over flammable liquids, suppressing fires.

In the paper industry, octanoic acid can be used in paper sizing and coating processes to improve printability and water resistance.
Octanoic acid derivatives can be used as processing aids and accelerators in the rubber industry during the manufacturing of rubber products.

Uses
Octanoic acid is a flavoring agent considered to be a short or medium chain fatty acid.
Octanoic acid occurs normally in various foods and is commercially prepared by oxidation of n-octanol or by fermentation and fractional distillation of the volatile fatty acids present.
Octanoic acid is used in maximum levels, as served, of 0.13% for baked goods; 0.04% for cheeses; 0.005% for fats and oils, frozen dairy desserts, gelatins and puddings, meat products, and soft candy; 0.016% for snack foods; and 0.001% or less for all other food categories.

Octanoic acid is widely applied in various fields, It is an antimicrobial pesticide used as a food contact surface sanitizer in commercial food handling establishments on dairy equipment, food processing equipment, breweries, wineries, and beverage processing plants.
In addition, Octanoic acid is used as an algaecide, bactericide, and fungicide in nurseries, greenhouses, garden centers, and interiorscapes on ornamentals.
Products containing Octanoic acid are formulated as soluble concentrate/liquids and ready-to-use liquids.

Octanoic acid is also used in the treatment of some bacterial infections.
Due to its relatively short chain length it has no difficulty in penetrating fatty cell wall membranes, hence its effectiveness in combating certain lipid-coated bacteria, such as Staphylococcus aureus and various species of Streptococcus.
Octanoic acid is used commercially in the production of esters used in perfumery and also in the manufacture of dyes.

Some studies have shown that Octanoic acid is effective to excess calorie burning taken as a dietary supplement, resulting in weigh loss.
Octanoic acid is used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Octanoic acid is an antimicrobial pesticide used as a food contact surface sanitizer in commercial food handling establishments on dairy equipment, food processing equipment, breweries, wineries, and beverage processing plants.

Octanoic acid is also used as disinfectant in health care facilities and public places.
In addition, Octanoic acid is used as an algicide, bactericide, fungicide, and herbicide in nurseries, greenhouses, garden centers, and interiors, and on ornamentation.
Products containing Octanoic acid are formulated as soluble concentrate/liquids and ready-to-use liquids.

Octanoic acid plays an important role in the body's regulation of energy input and output, a function which is performed by the hormone ghrelin.
The sensation of hunger is a signal that the body requires an input of energy in the form of food consumption.
Ghrelin stimulates hunger by triggering receptors in the hypothalamus.

In order to activate these receptors, ghrelin must undergo a process called acylation in which it acquires an acyl group, and Octanoic acid provides this by linking at a specific serine site on ghrelin molecules. Other fatty acids in the same position have similar effects on hunger.
The acyl chloride of Octanoic acid is used in the synthesis of perfluorooctanoic acid.
Octanoic acid is taken as a dietary supplement.

In the body, Octanoic acid would be found as octanoate, or unprotonated Octanoic acid.
Some studies have shown that medium-chain triglycerides (MCTs) can help in the process of excess calorie burning, and thus weight loss; however, a systematic review of the evidence concluded that the overall results are inconclusive.
Also, interest in MCTs has been shown by endurance athletes and the bodybuilding community, but MCTs have not been found to be beneficial to improved exercise performance.

Octanoic acid has been studied as part of a ketogenic diet to treat children with intractable epilepsy.
Octanoic acid is currently being researched as a treatment for essential tremor.
Octanoic acid is used in the following products: polymers, pH regulators and water treatment products, textile treatment products and dyes, washing & cleaning products, leather treatment products, adhesives and sealants and lubricants and greases.

Octanoic acid is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and formulation of mixtures and/or re-packaging.
Octanoic acid is used for the manufacture of: textile, leather or fur.
Release to the environment of Octanoic acid can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and as processing aid.

Octanoic acid is found naturally in various foods, including coconut oil, palm oil, cow's milk, and certain animal fats.
Octanoic acid contributes to the flavor and aroma of some dairy products.
Octanoic acid is a colorless to light yellow liquid at room temperature with a pungent, rancid odor.

Octanoic acid is soluble in organic solvents like ethanol and ether but has limited solubility in water.
Octanoic acid and its salts, such as sodium octanoate, are used as food additives and flavoring agents in the food industry.
They are often used to impart a buttery or creamy flavor to various food products.

Octanoic acid can be found in cosmetics and personal care products, including soaps, shampoos, and lotions, where it functions as a surfactant and emulsifying agent.
Octanoic acid is used in the pharmaceutical industry for various purposes, including as a component in drug formulations and as an excipient in the production of capsules and tablets.

Octanoic acid serves as a starting material in the synthesis of various chemicals, including esters, which have applications in perfumery and flavoring.
Some forms of octanoic acid and its derivatives have antimicrobial properties and are used in medical and healthcare settings.
Octanoic acid is sometimes used as an ingredient in insect repellents and pesticides due to its repellent properties.

In the metalworking industry, octanoic acid can be used as a lubricant and coolant in the machining process.
Octanoic acid can be used in the construction industry as a surface treatment to improve the adhesion of coatings, paints, and sealants to concrete surfaces.
Octanoic acid is employed in water treatment processes to help control odors and inhibit the growth of algae and microorganisms in water treatment facilities, particularly in wastewater treatment.

Octanoic acid and its derivatives are used in the production of biofuels, including biodiesel and biogas, as a source of energy in renewable fuel sources.
Octanoic acid can serve as a reference material and a standard in analytical chemistry, particularly in gas chromatography (GC) and liquid chromatography (LC) techniques.

In agriculture, octanoic acid derivatives are used as components in pesticide formulations to enhance their dispersion and effectiveness.
Octanoic acid can be used in the textile industry as a finishing agent to improve the texture and durability of textiles.
Octanoic acid is used in drilling fluids in the oil and gas industry to control viscosity and aid in drilling operations.

Octanoic acid can be used as a flotation agent to separate valuable minerals from ore.
Octanoic acid can be employed in leather tanning processes to modify and stabilize leather properties.
Octanoic acid is used in candle manufacturing to modify the melting point and improve the burning characteristics of candles.

Octanoic acid derivatives can be used in wood finishes, varnishes, and coatings to enhance their performance and appearance.
In aerosol products, octanoic acid can serve as a propellant, allowing the product to be dispensed as a fine mist or spray.
Octanoic acid is used in the production of biodegradable products, such as biodegradable plastics and surfactants, to reduce environmental impact.

Octanoic acid can be used in metal cleaning solutions to remove grease, oil, and other contaminants from metal surfaces.
Certain octanoic acid derivatives are employed as fixatives in perfumes and fragrances to extend the longevity of the scent.
Octanoic acid can be used as a blowing agent in the production of foam rubber products.

Octanoic acid is used as a flavoring agent in food products.
Octanoic acid provides a pleasant, buttery flavor and is used in items like baked goods, dairy products, and confections.
Octanoic acid has antimicrobial properties and can be used as a preservative in certain food products to extend

Octanoic acid is utilized in cosmetics and personal care products, such as perfumes and lotions, to contribute to their fragrance.
Octanoic acid is used in the pharmaceutical industry as a chemical intermediate and may be incorporated into the formulation of certain drugs.
Octanoic acid can be used to synthesize various esters, which are valuable compounds used in perfumes, flavorings, and as solvents.

Octanoic acid serves as a reagent in various chemical reactions due to its carboxyl group (-COOH) and can be used in the synthesis of other compounds.
Octanoic acid is sometimes used as a dietary supplement in ketogenic diets.
Octanoic acid is metabolized into ketones by the body, which can be an energy source during ketosis.

In some industrial settings, octanoic acid may be used as a lubricant.
Octanoic acid can be included in metalworking fluids to improve lubricity and reduce friction during machining processes.
Octanoic acid is used in perfumery to create specific scents and fragrances.

Safety Profile:
Octanoic acid moderately toxic by intravenous route.
Octanoic acid mildly toxic by ingestion.
Mutation data reported.

Octanoic acid a skin irritant.
Octanoic acid yields irritating vapors that can cause coughmg.
When heated to decomposition it emits acrid smoke and irritating fumes.

Octanoic acid is an irritant to the skin, eyes, and mucous membranes.
Contact with the skin can lead to irritation, redness, and discomfort.
Contact with the eyes can cause irritation, tearing, and potentially more serious eye damage if not promptly rinsed.

Inhaling vapors or mists of octanoic acid can lead to respiratory irritation.
Proper ventilation is important when working with this chemical.
Swallowing octanoic acid can result in irritation of the gastrointestinal tract, leading to nausea, vomiting, and abdominal discomfort.

While octanoic acid itself is not highly flammable, it can still pose a fire hazard under certain conditions, especially when exposed to open flames or high temperatures.
Octanoic acid may react with certain chemicals or materials, potentially leading to hazardous situations.

Toxicity:
While octanoic acid is generally considered safe when used in food and cosmetics at approved levels, excessive consumption or exposure can be harmful.
Ingesting large amounts may cause digestive discomfort and, in rare cases, more severe health effects.

Environmental Impact:
Improper disposal or release of octanoic acid into the environment can have negative ecological consequences.
Octanoic acid is important to follow proper disposal and environmental regulations.

Synonyms
octanoic acid
Octanoic acid
124-07-2
n-octanoic acid
Octylic acid
n-Octanoic acid
octoic acid
n-octylic acid
n-Octoic acid
1-heptanecarboxylic acid
Enantic acid
Octic acid
C-8 acid
Caprylsaeure
FEMA No. 2799
Kaprylsaeure
Hexacid 898
Acido octanoico
0ctanoic acid
Acide octanoique
1-octanoic acid
Acidum octanocium
Kyselina kaprylova
capryloate
C8:0
octylate
Octansaeure
Octanoic acid (natural)
Acide octanoique [French]
Acido octanoico [Spanish]
Acidum octanocium [Latin]
Kyselina kaprylova [Czech]
NSC 5024
NSC-5024
Octanoic acid [USAN:INN]
OCTANOIC ACID (Octanoic acid)
CCRIS 4689
HSDB 821
Kortacid-0899
CHEBI:28837
Emery 657
Prifac 2901
Prifac-2901
Lunac 8-95
EDENOR C 8-98-100
Octanoic acid-8-13C
EINECS 204-677-5
Octanoic acid-7-13C
MFCD00004429
BRN 1747180
UNII-OBL58JN025
CH3-[CH2]6-COOH
AI3-04162
OBL58JN025
DTXSID3021645
NSC5024
n-caprylate
n-octoate
n-octylate
Octanoic acid (NF)
NCGC00090957-01
C8H16O2
Octanoic acid (USAN)
1-heptanecarboxylate
EC 204-677-5
Octanoic acid [NF]
OCTANOIC ACID [USAN]
287111-08-4
4-02-00-00982 (Beilstein Handbook Reference)
68937-74-6
DTXCID501645
287111-23-3
CAS-124-07-2
Acid C8
287111-06-2
caprylic-acid
n-octanoicacid
Acide octanoque
octanic acid
acidum octanoicum
Copper as octanoate
Kortacid 0899
n-heptanecarboxylic acid
OAA (CHRIS Code)
Octanoic acid, ?99%
Lunac 8-98
Heptane-1-carboxylic acid
Octanoic acid, >=98%
Octanoic acid, >=99%
bmse000502
D0XS4G
Octanoic acid [MI]
OCTANOIC ACID [II]
SCHEMBL3933
WLN: QV7
NCIOpen2_002902
NCIOpen2_009358
Octanoic acid (USAN/INN)
OCTANOIC ACID [INN]
Octanoic acid [INCI]
OCTANOIC ACID [FHFI]
OCTANOIC ACID [HSDB]
MLS002415762
Octanoic acid, >=96.0%
Octanoic acid (octanoic acid)
Octanoic acid [VANDF]
IS_D15-OCTANOIC ACID
OCTANOIC ACID [MART.]
CHEMBL324846
GTPL4585
Octanoic acid, >=98%, FG
QSPL 011
QSPL 184
Octanoic acid [USP-RS]
OCTANOIC ACID [WHO-DD]
Octanoic acid; (Octanoic acid)
HMS2270A23
Octanoic acid, analytical standard
Octanoic acid [EP IMPURITY]
STR10050
EINECS 273-085-7
Tox21_111045
Tox21_201279
Tox21_300345
BDBM50485608
Octanoic acid [EP MONOGRAPH]
CAPRYLIC-ACID, NATURAL (C8)
FA 8:0
LMFA01010008
LS-691
s6296
STL282742
AKOS000118802
Octanoic acid, natural, >=98%, FG
DB04519
FA(8:0)
Octanoic acid, for synthesis, 99.5%
NCGC00090957-02
NCGC00090957-03
NCGC00090957-04
NCGC00090957-05
NCGC00254446-01
NCGC00258831-01
BP-27909
HY-41417
SMR001252279
CS-0016549
FT-0660765
O0027
EN300-21305
C06423
D05220
Q409564
SR-01000865607
J-005040
SR-01000865607-2
BRD-K35170555-001-07-9
Z104495238
Octanoic acid (CONSTITUENT OF SAW PALMETTO) [DSC]
Octanoic acid, certified reference material, TraceCERT(R)
43FDA9D7-2300-41E7-A373-A34F25B81553
Octanoic acid, European Pharmacopoeia (EP) Reference Standard
Octanoic acid, United States Pharmacopeia (USP) Reference Standard
Octanoic acid (Octanoic Acid), Pharmaceutical Secondary Standard; Certified Reference Material
OCTANOIC ACID
Synonyms: emery 658 | edenor c 8-70 | c 810 | acypetacs | fettsuren, c8-10 | c 810l | c8-10 fatty acids | fatty acids-(c8-c10) | delspray | edenor v85 | emery 6358 | bfc-dry | edenor v 85kr | fatty acids, c8-10 ,(EDENOR C8-10)CAS No.:68937-75-7
OCTANOIC/DECANOIC ACID TRIGLYCERIDE
DESCRIPTION:


Octanoic/Decanoic Acid Triglyceride is a compound that comes from combining fatty acids with glycerin.
The fatty acids in the compound are medium-chain triglycerides (MCTs).
The Cosmetic Ingredient Review (CIR) note that these fatty acids come from rich oils, such as coconut or palm oil.


Molecular Formula: C21H44O7
Average mass: 408.570 Da
Monoisotopic mass: 408.308716 Da

Manufacturers remove and isolate fatty acids from the oil as caprylic acid.
They combine these pure fatty acids with glycerin to make capric or caprylic triglyceride.
The manufacturers then use several other processes to purify the compound.



The CIR suggest that the end product typically contains impurities at about 300 parts per million free fatty acids and up to 0.2% glycerol.
Some manufacturers may label caprylic triglyceride as a natural product, which is misleading.


Although the compound has natural origins, it takes several stages of processing to purify and stabilize the compound in the end product. Caprylic triglyceride is highly purified and refined.
Some manufacturers incorrectly refer to the compound as fractionated coconut oil or MCT oil, but these oils are from a different compound.


Octanoic/Decanoic Acid Triglyceride is an oily liquid derived from caprylic and capric fatty acids (typically sourced from coconut oil) and glycerin.
Octanoic/Decanoic Acid Triglyceride is saturated fatty acids found naturally in plant oils such as coconut and palm.

The Octanoic/Decanoic Acid Triglyceride we use is from plant (non-animal) origins.
Octanoic/Decanoic Acid Triglyceride can be produced by reacting coconut oil with glycerin, which separates or ‘fractionates’ the glycerides.
‘Caprylic’ and ‘Capric’ are names to describe the length of the resulting fatty acid molecules: 8 carbons long for caprylic and 10 for capric.


The fractionating process removes almost all the long chain triglycerides, leaving mostly medium chain triglycerides and making it a more saturated oil.
This saturation gives it a long shelf life and makes it more stable.
Fractionating the oil raises the comparative concentration of capric acid and caprylic acid, giving it greater antioxidant properties.


Octanoic/Decanoic Acid Triglyceride can be used in skin care products as a gentle, non-greasy emollient.
Octanoic/Decanoic Acid Triglyceride helps restore the skin's protective barrier while replenishing moisture, leaving skin soft and smooth.
Similarly, when used in hair care products Octanoic/Decanoic Acid Triglyceride creates a protective barrier on the hair surface, helping to retain moisture and prevent dryness.


Octanoic/Decanoic Acid Triglyceride is triglyceride derived from glycerol and 3 medium chain fatty acids (C8 - C10).

Properties of the natural ingredient makes Octanoic/Decanoic Acid Triglyceride suitable for use in various applications.
• Fast Spreading, light skin feel - personal care ingredient
• Oxidative stability, low viscosity, clean organoleptic quality - solvent for flavour, pharmaceautical, lubricant
• Lower caloric value, rapid available source of energy - health management

Octanoic/Decanoic Acid Triglyceride is a medium-chain triglyceride used as a component of ointments, creams, and liquid emulsions.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.



Octanoic/Decanoic Acid Triglyceride is obtained from fractionation of a lauric-type oil.
Octanoic/Decanoic Acid Triglyceride obtained has a melting point of about 7 ° C.
When in liquid form, Octanoic/Decanoic Acid Triglyceride is almost colourless and with a characteristic odour.

Also known as MCT (medium chain triglyceride).
Octanoic/Decanoic Acid Triglyceride has an almost equal composition of caprylic and capric acids.

Fractionated fatty acids are mainly applied to the manufacture of: Amines, esters, fatty alcohols, peroxides, fragrances, flavors, surface finishing, lubricants, metal soaps, cosmetics, animal feed, chemical, paper, plastics, detergents, chemicals, resins and coatings.


Octanoic/Decanoic Acid Triglyceride is a super smooth ingredient that locks in moisture on the skin and hair without leaving them greasy or oily.
Octanoic/Decanoic Acid Triglyceride is found in a large variety of cosmetic and skin care products such as lipstick, eyeliners, and moisturizers.
Octanoic/Decanoic Acid Triglyceride is also an antioxidant that protects the skin and preserves the product it is added in.
Even though Octanoic/Decanoic Acid Triglyceride is derived from oils, Caprylic/capric triglyceride is not comedogenic and does not cause acne or breakouts.








USES OF OCTANOIC/DECANOIC ACID TRIGLYCERIDE:
Caprylic triglyceride has various uses, including:
Skin care:
Octanoic/Decanoic Acid Triglyceride is a stable compound that has an oily texture.
Octanoic/Decanoic Acid Triglyceride can create a barrier on the skin’s surface to lock in moisture.

Several skin care products contain caprylic triglyceride, such as:
• face creams
• body moisturizers
• sunscreens
• eye creams
• anti-aging serums

Makeup:
Octanoic/Decanoic Acid Triglyceride is also a stable alternative to other oils.
Cosmetics and makeup containing fatty compounds may use caprylic triglyceride.
These products include:
• lip balm
• lip liner
• lipstick
• eyeliner
• liquid foundation or blush

Manufacturers may prefer the compound over other options because Octanoic/Decanoic Acid Triglyceride is smooth but not sticky or greasy.


Foods:
Caprylic acid, the base for caprylic triglyceride, may also be present in preprepared foods, such as:
• baked goods
• soft candies
• cheeses
• frozen dairy products
• gelatins and puddings
• meat products

BENEFITS OF OCTANOIC/DECANOIC ACID TRIGLYCERIDE:
Caprylic triglyceride is a compound of glycerin and naturally occurring fatty acids from coconut or palm oil.
Octanoic/Decanoic Acid Triglyceride may have some benefits for the skin or the products that contain it.

Emollient:
An emollient is an ingredient that softens the skin.
Emollients form a protective layer on the skin, locking in moisture to prevent the skin from drying out.
The oily texture of Octanoic/Decanoic Acid Triglyceride makes it a useful skin softener.


Antioxidants:
Antioxidants serve several purposes in the body.
For example, antioxidants can fight skin cell damage from the environment.
The fatty acids in caprylic acid are antioxidants.

Solvent:
Solvents help dissolve certain ingredients.
Octanoic/Decanoic Acid Triglyceride is an oily compound that can prevent ingredients from clumping together.
Due to this property, it could improve the texture of products that contain the compound.


Dispersing agent:
A dispersing agent stabilizes and binds ingredients in a product.
Octanoic/Decanoic Acid Triglyceride may help evenly distribute product ingredients, such as solid pigments, scents, or other compounds.
This even distribution can create a more consistent texture and stable blend.

Interrupts microbial growth:
Face products can change the microbial balance of the skin.
They feed or inhibit certain types of microbes, particularly those that affect fat compounds.



Octanoic/Decanoic Acid Triglyceride is used primarily in many industrial processes and as an additive to certain products.
Octanoic/Decanoic Acid Triglyceride is a chemical intermediate and lubricant, a solubilizer for mineral oils and a flotation aid frequently used in the oil and gas industry.
Octanoic/Decanoic Acid Triglyceride is also employed in the production of medium chain triglycerides (MCT), synthetic fats that are used medicinally by people unable to tolerate other types of fat.

Lubricants and Greases:
Octanoic/Decanoic Acid Triglyceride is Used in the Manufacture of Synthetic Lubricants, Hydraulic Fluids and Refrigerant Lubricant.
Octanoic/Decanoic Acid Triglyceride Acts as a Corrosion and Rust Inhibitor in Antifreeze

Food and Flavor:
Octanoic/Decanoic Acid Triglyceride is Intermediate to make MCT (Medium Chain Triglycerides)

Metal Working Fluids:
Octanoic/Decanoic Acid Triglyceride is Solubilizer for Mineral Oils Oil and Gas: Flotation Aid











CHEMICAL AND PHYSICAL PROPERTIES OF OCTANOIC/DECANOIC ACID TRIGLYCERIDE:
IUPAC Name
decanoic acid; octanoic acid; propane-1,2,3-triol
Molecular Weight
372.54
Molecular Formula
C21H40O5
InChI Key
STORWMDPIHOSMF-UHFFFAOYSA-N
Boiling Point
456ºC at 760 mmHg
Flash Point
142.6ºC
Density
0.94-0.96
Appearance
Transparent or yellowish clear liquid
Exact Mass
464.33500
H-Bond Acceptor
7
H-Bond Donor
5
APPEARANCE AT 20°C
Clear mobile liquid
COLOR
Colorless to pale yellow
ODOR
Odorless
OPTICAL ROTATION (°)
0 / 0
DENSITY AT 20°C (G/ML))
0,940 - 0,960
REFRACTIVE INDEX ND20
1,4400 - 1,4520
FLASHPOINT (°C)
250
SOLUBILITY
Insoluble in water
ASSAY (% GC)
Octanoic acid ester 50-65% and decanoic 30-45%
ACID VALUE (MG KOH/G)
< 0.2
Density, 0.94-0.96
vapor pressure, 0-0Pa at 20℃
solubility, Soluble in all proportions at 20°C in acetone, benzene, 2-butanone, carbon tetrachloride, chloroform, dichloromethane, ethanol, ethanol (95%), ether, ethyl acetate, petroleum ether, special petroleum spirit (boiling range 80–110°C), propan- 2-ol, toluene, and xylene. Miscible with long-chain hydrocarbons and triglycerides; practically insoluble in water.
form, Liquid
InChI, InChI=1S/C21H40O6/c1-2-3-4-10-13-18(21(26)27-17-19(23)16-22)14-11-8-6-5-7-9-12-15-20(24)25/h18-19,22-23H,2-17H2,1H3,(H,24,25)/p-1
InChIKey, YWHITOKQSMJXEA-UHFFFAOYSA-M
SMILES, C([O-])(=O)CCCCCCCCCC(C(OCC(O)CO)=O)CCCCCC
LogP, 8.2-10.9
Appearance, A colorless or slightly yellow oily liquid
Lodine Value (mgI2/100g), ≤1.0
Acid Value (KOH/g), ≤0.1
Saponification Value, 325~360
Specific Gravity, 0.940~0.955
Heavy Metal (Pb) mg/kg, ≤10
Arsenic (As) mg/kg, ≤2
Peroxide Value, ≤1.0




SAFETY INFORMATION ABOUT OCTANOIC/DECANOIC ACID TRIGLYCERIDE:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






SYNONYMS OF OCTANOIC/DECANOIC ACID TRIGLYCERIDE:
2-Hydroxy-3-(octanoyloxy)propyl decanoate [ACD/IUPAC Name]
72480-00-3 [RN]
97794-26-8 [RN]
CAPRIC ACID; CAPRYLIC ACID; GLYCEROL
Caprylic / Capric Triglyceride
Caprylic acid, capric acid triglyceride
caprylic capric triglycerride
Caprylic/capric triglyceride
Decanoic acid, ester with 1,2,3-propanetriol octanoate
decanoic acid;octanoic acid;propane-1,2,3-triol
Decanoyl/octanoyl-glycerides
Glycerides, C8-10
Medium Chain Triglyceride Oil
Octanoic/decanoic acid triglyceride
s24816




OCTANOIC-DECANOIC (CAPRYLIC-CAPRIC)
OCTENIDINE HCL, N° CAS : 70775-75-6. Origine(s) : Synthétique. Nom INCI : OCTENIDINE HCL. Nom chimique : 1-Octanamine, N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, dihydrochloride. N° EINECS/ELINCS : 274-861-8. Ses fonctions (INCI): Antimicrobien : Aide à ralentir la croissance de micro-organismes sur la peau et s'oppose au développement des microbes
OCTANOL
Octanol is a linear primary alcohol.
Octanol is an organic alcohol with a six-carbon chain and a condensed structural formula of CH3(CH2)5OH.
Octanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.

CAS Number: 111-27-3
EC Number: 203-852-3
Molecular Formula: C6H14O
Molecular Weight (g/mol): 102.177

Two additional straight chain isomers of Octanol, 2-Octanol and 3-Octanol, exist, both of which differing by the location of the hydroxyl group.
Many isomeric alcohols have the formula C6H13OH.
Octanol is used in the perfume industry.

Octanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.
Further, Octanol serves as a perturbing agent on actomyosin adenosine triphosphatease.
In addition to this, Octanol is used to modulate the function of actomyosin motor.

Octanol is an organic alcohol with a six carbon chain and a condensed structural formula of CH3(CH2)5OH.
This colorless liquid is slightly soluble in water, but miscible with ether and ethanol.

Two additional straight chain isomers of Octanol exist, 2-Octanol and 3-Octanol, both of which differ by the location of the hydroxyl group.
Many isomeric alcohols have the formula C6H13OH.

Octanol is an organic alcohol with a six-carbon chain and a condensed structural formula of CH3(CH2)5OH.
This colorless liquid is slightly soluble in water, but miscible with diethyl ether and ethanol.

Octanol is believed to be a component of the odour of freshly mown grass.
Octanol is used in the perfume industry.

Octanol is an organic alcohol with a six carbon chain and a condensed structural formula of CH3(CH2)5OH.
This colorless liquid is slightly soluble in water, but miscible with ether and ethanol.

Octanol is a linear primary alcohol.
Octanol is formed as an intermediate during the catalytic transformation of cellulose.

The ability of 1,1,3,3-tetramethylguanidine (TMG) in Octanol solvent system to capture carbon dioxide has been assessed.
The solubility of light fullerenes in Octanol as a function of temperature and pressure was studied.

Octanol is produced from coconut oil and palm oils.
Octanol is used in the production of antiseptics, fragrances and perfumes.
Octanol is also used as a solvent in the production of plasticizers.

Two additional straight chain isomers of Octanol exist, 2-Octanol and 3-Octanol, both of which differ by the location of the hydroxyl group.
Many isomeric alcohols have the formula C6H13OH.
Octanol is an alcohol extracted from yeast and produced during fermentation of alcoholic beverages.

Applications of Octanol:
Octanol is used to make plasticizers for polyvinyl chloride.
Reaction with phthalic anhydride gives bis(2-ethyl hexyl) phthalate (DOP, DEHP).

Reaction with adipic acid gives bis(2-ethyl hexyl) adipate.
Moreover, esterification with acrylic acid gives 2-ethyl hexyl acrylate for use in adhesives and paints.
On the other hand, because Octanol can dissolve many organic materials well, Octanol is widely used as a low-volatility solvent.

Octanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics.
Further, Octanol serves as a perturbing agent on actomyosin adenosine triphosphatease.
In addition to this, Octanol is used to modulate the function of actomyosin motor.

Uses of Octanol:
Octanol is used to produce plasticizers, antiseptics, fragrances, pharmaceuticals, and finishing agents for textile and leather.
Octanol is used as a flavoring agent and a solvent for fats, waxes, dyes, and paints.

Octanol is synthetic flavoring ingredient
Octanol is used in pharmaceuticals (introduction of hexyl group into hyponics, antiseptics, perfume esters, etc), solvent, plasticizer, intermediate for textile and leather finishing agents.

Industry Uses:
Aerating and deaerating agents
Fuel
Intermediate
Lubricating agent
Monomers
Solvent
Solvents (which become part of product formulation or mixture)
Surfactant (surface active agent)
Wetting agent (non-aqueous)

Consumer Uses:
Flavoring and nutrient
Fuel
Lubricating agent
Monomers
Solvent

Industrial Processes with risk of exposure:
Painting (Solvents)

Preparation of Octanol:
Octanol is produced industrially by the oligomerization of ethylene using triethylaluminium followed by oxidation of the alkylaluminium products.

An idealized synthesis is shown:
Al(C2H5)3 + 6C2H4 → Al(C6H13)3
Al(C6H13)3 + 1+1⁄2O2 + 3H2O → 3HOC6H13 + Al(OH)3

The process generates a range of oligomers that are separated by distillation.

Alternative methods:
Another method of preparation entails hydroformylation of 1-pentene followed by hydrogenation of the resulting aldehydes.
This method is practiced in industry to produce mixtures of isomeric C6-alcohols, which are precursors to plasticizers.

In principle, 1-hexene could be converted to Octanol by hydroboration (diborane in tetrahydrofuran followed by treatment with hydrogen peroxide and sodium hydroxide).
This method is instructive and useful in laboratory synthesis but of no practical relevance because of the commercial availability of inexpensive Octanol from ethylene.

Manufacturing Methods of Octanol:
Addition of ethylene to triethylaluminum followed by oxidation of the growth product, hydrolysis, and fractional distillation; from condensation of n-butyraldehyde and acetaldehyde, followed by dehydration and hydrogenation.

Laboratory preparation by action of butylmagnesium bromide on ethylene oxide 1,3-hexadienal with iron wire in presence of nickel acetate
Industrial preparation by reducing ethyl caproate with sodium in absolute alcohol.

Reaction of acetaldehyde and crotonaldehyde followed by hydrogenation.

General Manufacturing Information of Octanol:

Industry Processing Sectors:
Agriculture, Forestry, Fishing and Hunting
All Other Basic Organic Chemical Manufacturing
Mining (except Oil and Gas) and support activities
Oil and Gas Drilling, Extraction, and Support activities
Other (requires additional information)
Paint and Coating Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Petrochemical Manufacturing
Petroleum Lubricating Oil and Grease Manufacturing
Plastics Material and Resin Manufacturing
Plastics Product Manufacturing

Commercial products from the family of 6 to 11 carbon alcohols that make up the plasticizer range are available both as pure single carbon chain materials and as complex isomeric mixtures.
Commercial descriptions of plasticizer range alcohols are in general a pure material is called "-anol" /eg, Octanol/, and the mixtures are called "-yl alcohol /eg, hexyl alcohol/ or "iso...yl alcohol" /isohexyl alcohol/.

Occurrence in Nature of Octanol:
Octanol is believed to be a component of the odour of freshly mown grass.
Alarm pheromones emitted by the Koschevnikov gland of honey bees contain Octanol.
Octanol also is partly responsible for the fragrance of strawberries.

Characteristics of Octanol:
Octanol, also called octanol, is an 8-carbon higher alcohol species.
Octanol is hardly soluble in water, but is soluble in almost all organic solvents.
Our Octanol has very low-level impurities and may be used as a raw material for a wide variety of chemicals.

MeSH Pharmacological Classification of Octanol:

Nicotinic Antagonists:
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists.
Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.

Anesthetics:
Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain.
They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.

Action Mechanism of Octanol:
Ethanol and Octanol were found to have two competing concentration-dependent effects on the Ca(2+)- and phorbol ester- or diacylglycerol-dependent activities of PKCalpha associated with either RhoA or Cdc42, consisting of a potentiation at low alcohol levels and an attenuation of activity at higher levels.
Measurements of the Ca(2+), phorbol ester, and diacylglycerol concentration-response curves for Cdc42-induced activation indicated that the activating effect corresponded to a shift in the midpoints of each of the curves to lower activator concentrations, while the attenuating effect corresponded to a decrease in the level of activity induced by maximal activator levels.
The presence of ethanol enhanced the interaction of PKCalpha with Cdc42 within a concentration range corresponding to the potentiating effect, whereas the level of binding was unaffected by higher ethanol levels that were found to attenuate activity.

Human Metabolite Information of Octanol:

Cellular Locations:
Extracellular
Membrane

Reactivity Profile of Octanol:
Octanol is an alcohol.
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents.

They react with oxoacids and carboxylic acids to form esters plus water.
Oxidizing agents convert them to aldehydes or ketones.

Alcohols exhibit both weak acid and weak base behavior.
They may initiate the polymerization of isocyanates and epoxides.

Handling and Storage of Octanol:

Nonfire Spill Response:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
All equipment used when handling the product must be grounded.

Do not touch or walk through spilled material.
Stop leak if you can do Octanol without risk.

Prevent entry into waterways, sewers, basements or confined areas.
A vapor-suppressing foam may be used to reduce vapors.

Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL:
Dike far ahead of liquid spill for later disposal.
Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Safe Storage:
Separated from strong oxidants.

Storage Conditions:
Protect containers against physical damage.
Keep containers closed and store in well-ventilated, cool place.

Fire Fighting of Octanol:
The majority of these products have a very low flash point.
Use of water spray when fighting fire may be inefficient.

SMALL FIRE:
Dry chemical, CO2, water spray or alcohol-resistant foam.
Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE:
Water spray, fog or alcohol-resistant foam.
Avoid aiming straight or solid streams directly onto the product.
If Octanol can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS:
Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.

Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

For massive fire, use unmanned master stream devices or monitor nozzles.
If this is impossible, withdraw from area and let fire burn.

Use alcohol-resistant foam, dry powder, carbon dioxide.
In case of fire: keep drums, etc., cool by spraying with water.

Fire Fighting Procedures of Octanol:
Use carbon dioxide, dry chemical or "alcohol" foam extinguisher.
Water is ineffective to fire fighting, but is effective to keep fire-exposed containers cool.

If material on fire or involved in fire:
Do not extinguish fire unless flow can be stopped.
Use water in flooding quantities as fog.

Solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water.

Apply water from as far a distance as possible.
Use "alcohol" foam, carbon dioxide or dry chemical.
Keep run off water out of sewers and water sources.

Accidental Release Measures of Octanol:

IMMEDIATE PRECAUTIONARY MEASURE:
Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL:
Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE:
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions.
Also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Spillage Disposal of Octanol:

Personal protection:
Filter respirator for organic gases and vapours adapted to the airborne concentration of Octanol.
Collect leaking and spilled liquid in covered containers as far as possible.

Absorb remaining liquid in sand or inert absorbent.
Then store and dispose of according to local regulations.

Cleanup Methods of Octanol:
Absorb on paper.
Evaporate on a glass or iron dish in hood.
Burn the paper.

Disposal Methods of Octanol:
The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination.
Recycle any unused portion of the material for Octanol approved use or return it to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
The material's impact on air quality.
Potential migration in soil or water

Effects on animal, aquatic, and plant life.
Conformance with environmental and public health regulations.

Spray into the furnace.
Incineration will become easier by mixing with a more flammable solvent.

Preventive Measures of Octanol:

If material not on fire and not involved in fire:
Keep sparks, flames, and other sources of ignition away.
Keep material out of water sources and sewers.

Build dikes to contain flow as necessary.
Attempt to stop leak if without undue personnel hazard.
Use water spray to knock-down vapors.

Personnel protection:
Avoid breathing vapors.
Avoid bodily contact with the material.

Do not handle broken packages unless wearing appropriate personal protective equipment.
Wash away any material which may have contacted the body with copious amounts of water or soap and water.
If contact with the material anticipated, wear appropriate chemical protective clothing.

Identifiers of Octanol:
CAS Number: 111-27-3
Beilstein Reference 969167
ChEBI: CHEBI:87393
ChEMBL: ChEMBL14085
ChemSpider: 7812
ECHA InfoCard: 100.003.503
EC Number: 203-852-3
MeSH: 1-Octanol
PubChem CID: 8103
RTECS number: MQ4025000
UNII: 6CP2QER8GS
UN number: 2282
CompTox Dashboard (EPA): DTXSID8021931
InChI: InChI=1S/C6H14O/c1-2-3-4-5-6-7/h7H,2-6H2,1H3
Key: ZSIAUFGUXNUGDI-UHFFFAOYSA-N
SMILES: CCCCCCO

CAS number: 111-27-3
EC index number: 603-059-00-6
EC number: 203-852-3
Hill Formula: C₆H₁₄O
Molar Mass: 102.18 g/mol
HS Code: 2905 19 00

Synonym(s): Hexyl alcohol
Linear Formula: CH3(CH2)5OH
CAS Number: 111-27-3
Molecular Weight: 102.17
Beilstein: 969167
EC Number: 203-852-3
MDL number: MFCD00002982
PubChem Substance ID: 57650899
NACRES: NA.21

CAS: 111-27-3
Molecular Formula: C6H14O
Molecular Weight (g/mol): 102.177
MDL Number: MFCD00002982
InChI Key: ZSIAUFGUXNUGDI-UHFFFAOYSA-N
PubChem CID: 8103
ChEBI: CHEBI:87393
IUPAC Name: hexan-1-ol
SMILES: CCCCCCO

Properties of Octanol:
Chemical formula: C6H14O
Molar mass: 102.177 g·mol−1
Appearance colorless: liquid
Density: 0.82 g cm−3 (at 20 °C)[2]
Melting point: −45 °C (−49 °F; 228 K)
Boiling point: 157 °C (315 °F; 430 K)
Solubility in water: 5.9 g/L (at 20 °C)
log P: 1.858
Vapor pressure: 100 Pa (at 25.6 °C)
Refractive index (nD): 1.4178 (at 20 °C)

Density: 0.82 g/cm3 (20 °C)
Explosion limit: 1.2 - 7.7 %(V)
Flash point: 60 °C
Ignition temperature: 285 °C
Vapor pressure: 3.64 hPa (38 °C)
Viscosity kinematic: 3.64 mm2/s (40 °C)
Solubility: 1.3 g/l

Grade: anhydrous
Quality Level: 100
Vapor density: 4.5 (vs air)
Vapor pressure: 1 mmHg ( 25.6 °C)
Assay: ≥99%
Form: liquid
Autoignition temp.: 559 °F
Expl. lim.: 0.34-6.3 %
Impurities: <0.005% water
evapn. residue: <0.0005%
Refractive index: n20/D 1.418 (lit.)
bp: 156-157 °C (lit.)
mp: −52 °C (lit.)
Density: 0.814 g/mL at 25 °C (lit.)
SMILES string: CCCCCCO
InChI: 1S/C6H14O/c1-2-3-4-5-6-7/h7H,2-6H2,1H3
InChI key: ZSIAUFGUXNUGDI-UHFFFAOYSA-N

Molecular Weight: 102.17
XLogP3: 2
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 4
Exact Mass: 102.104465066
Monoisotopic Mass: 102.104465066
Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 7
Complexity: 27.4
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Octanol:
Assay (GC, area%): ≥ 98 %
Density (d 20 °C/ 4 °C): 0.818 - 0.819
Identity (IR): passes test

Melting Point: -52°C
Density: 0.814
Boiling Point: 157°C
Flash Point: 60°C (140°F)
Assay Percent Range: 99%
Linear Formula: CH3(CH2)5OH
UN Number: UN2282
Beilstein: 969167
Merck Index: 14,4697
Refractive: Index 1.418
Quantity: 2500 mL
Solubility Information: Miscible with ethanol, acetone, chloroform, ether, benzene. Slightly miscible with carbon tetrachloride and water.
Formula Weight: 102.18
Percent Purity: 99%
Chemical Name or Material: 1-Octanol

Thermochemistry of Octanol:
Heat capacity (C): 243.2 J K−1 mol−1
Std molar entropy (S⦵298): 287.4 J K−1 mol−1
Std enthalpy of formation (ΔfH⦵298): −377.5 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): −3.98437 MJ mol−1

Names of Octanol:

Preferred IUPAC name:
Hexan-1-ol

Other names:
amyl carbinol

Synonyms of Octanol:
1-Hexanol
Hexan-1-ol
Hexyl alcohol
111-27-3
HEXANOL
n-Hexanol
n-Hexyl alcohol
Amylcarbinol
1-Hydroxyhexane
1-Hexyl alcohol
Caproyl alcohol
Pentylcarbinol
Caproic alcohol
n-Hexan-1-ol
C6 alcohol
Alcohol(C6)
Hexanol (VAN)
EPAL 6
Hexyl alcohol (natural)
Alcohol C-6
FEMA No. 2567
NSC 9254
MFCD00002982
Hexanol-(1)
6CP2QER8GS
25917-35-5
CHEBI:87393
NSC-9254
Caswell No. 482E
Hydroxyhexane
Hexanols
FEMA Number 2567
CAS-111-27-3
HE2
HSDB 565
EINECS 203-852-3
UNII-6CP2QER8GS
EPA Pesticide Chemical Code 079047
BRN 0969167
Caproalcohol
Hexalcohol
HEXYL ALCOHOL, ACTIVE
n-hexylalcohol
AI3-08157
N-hexenol
Nat.Hexanol
Exxal 6
EINECS 247-346-0
HEXANOL-CMPD
Exxal 6 (Salt/Mix)
BDBM9
1-Hexanol, 98%
Hexyl alcohol, FCC, FG
1-HEXANOL [HSDB]
1-HEXANOL [MI]
EC 203-852-3
n-C6H13OH
SCHEMBL1877
HEXYL ALCOHOL [FCC]
NATURAL HEXYL ALCOHOL
C6H13OH
HEXYL ALCOHOL [FHFI]
HEXYL ALCOHOL [INCI]
WLN: Q6
4-01-00-01694 (Beilstein Handbook Reference)
MLS001055374
UN 2282 (Salt/Mix)
BIDD:ER0298
CHEMBL14085
1-Hexanol, analytical standard
DTXSID8021931
1-Hexanol, anhydrous, >=99%
NSC9254
1-Hexanol, reagent grade, 98%
DTXSID001022586
HMS3039L08
BCP29486
ZINC1699882
Tox21_201335
Tox21_302953
LMFA05000117
STL282713
UN2282
AKOS009031422
HY-W032022
Alcohol C-6, Natural, Natural Hexanol
1-Hexanol, purum, >=98.0% (GC)
1-Hexyl alcohol pound>>1-Hexylalcohol
NCGC00090949-01
NCGC00090949-02
NCGC00256385-01
NCGC00258887-01
Hexanols [UN2282] [Flammable liquid]
LS-13216
SMR000677945
1-Hexanol, SAJ special grade, >=99.0%
1-Hexanol, Vetec(TM) reagent grade, 98%
CS-0076046
FT-0607887
H0130
Hexyl alcohol, natural, >=98%, FCC, FG
EN300-19338
Q76933
1-Hexanol, ReagentPlus(R), >=99.5% (GC)
J-002549
F0001-0237
Z104473568
111-27-3 [RN]
1-Hexanol [ACD/Index Name] [ACD/IUPAC Name]
1-Hexanol [German] [ACD/Index Name] [ACD/IUPAC Name]
1-Hexanol [French] [ACD/Index Name] [ACD/IUPAC Name]
1-hexyl alcohol
1-Hydroxyhexane
203-852-3 [EINECS]
4-01-00-01694 [Beilstein]
Caproic alcohol
Caproyl alcohol
hexan-1-ol
hexanol [Wiki]
Hexyl alcohol
MFCD00002982 [MDL number]
n-Hexan-1-ol
n-hexanol
n-Hexyl alcohol
1-Hexan-d13-ol
1-hexanol [Portuguese] [ACD/Index Name] [ACD/IUPAC Name]
1-hexanol, purified
52598-04-6 [RN]
BNG
B-Nonylglucoside
C8E
decane, 1,3,5,7-Tetraazatricyclo(3.3.1.13,7)
Epal 6
Exxal 6
Hexalin
Hexane [ACD/Index Name] [ACD/IUPAC Name]
Hexyl alcohol203-852-3MFCD00002982
Hexylalcohol
n-C6H13OH [Formula]
OCTAQUEST E 30
DESCRIPTION:

Octaquest E 30 is a biodegradable chelating agent that is special in the fact that it is very selective towards problematic transition metals such as Cu and Fe compared to Ca and Mg.
This makes Octaquest E 30 ideal in personal care formulations as it is tackling these problematic transition metals first while in the formulation, but still giving hard water control when released into water.
This gives Octaquest E 30 the benefit of excellent anti-oxidant properties and foam preservation in shampoos and conditioners.



CAS NUMBER: 178949-82-1

EC NUMBER: 416-530-4

MOLECULAR FORMULA: C10H16N2O8.3Na

MOLECULAR WEIGHT: 292.24 g/mol.



DEFINITION:

Octaquest E 30 is a chelating agent that belongs to the class of aminopolycarboxylic acids.
Octaquest E 30 is a highly effective chelating agent for a wide range of metal ions, especially those with a high affinity for oxygen.
Octaquest E 30 forms stable complexes with metal ions, helping to prevent their undesired reactions and facilitating their controlled utilization in various applications.
Octaquest E 30 offers versatile metal ion control capabilities.

Octaquest E 30 can chelate and sequester metal ions, preventing them from causing undesired effects such as oxidation, precipitation, or catalysis of unwanted reactions.
This feature is particularly useful in industries where precise control of metal ions is essential, such as cleaning, detergent, and plating processes.
The chelation capacity of Octaquest E 30 is pH-dependent.
Octaquest E 30 exhibits high chelating efficiency and stability in slightly acidic to neutral pH ranges.

This pH sensitivity allows for tailored applications, as the chelation performance can be optimized within specific pH conditions.
Octaquest E 30 is known for its environmental friendliness.
Octaquest E 30 is biodegradable, meaning it can undergo natural decomposition over time.
This characteristic contributes to reducing potential environmental impact and aligns with sustainability goals.

Octaquest E 30 helps improve the stability of formulations by preventing metal-induced degradation or precipitation.
By chelating metal ions, Octaquest E 30 protects formulations from unwanted reactions and maintains their quality, appearance, and performance over time.
Octaquest E 30 is derived from ethylenediamine, a compound with two amino groups (-NH2) and two ethylene groups (-CH2CH2-).
Octaquest E 30 offers several benefits due to its chelating properties and other characteristics.
Octaquest E 30 is highly effective at chelating or sequestering metal ions, particularly those with a high affinity for oxygen, such as iron, copper, and zinc.

By forming stable complexes with these metal ions, Octaquest E 30 helps to prevent their undesirable reactions, such as oxidation or precipitation, which can lead to product degradation or performance issues.
Octaquest E 30 has good water solubility, which makes it easy to incorporate into various formulations, such as cleaning products, detergents, and industrial solutions.

Its solubility allows for effective metal ion control and chelation in aqueous systems.
Octaquest E 30 is biodegradable, which is a desirable characteristic for applications where environmental impact is a concern.
Octaquest E 30 can break down naturally into simpler compounds, reducing the potential for long-term accumulation in the environment.
Octaquest E 30 is particularly beneficial in soil remediation applications.

Octaquest E 30 helps to mobilize and chelate heavy metals in contaminated soil, making them more accessible for extraction or degradation.
This can aid in the remediation of metal-contaminated sites and promote environmental restoration.
As a chelating agent, EDDS can enhance the stability of formulations by preventing metal-induced degradation or precipitation.
Octaquest E 30 helps to maintain the effectiveness and shelf life of products by protecting against metal-catalyzed reactions or undesirable changes in color, odor, or texture.

Octaquest E 30 is used in metal plating processes, such as electroplating, to improve the quality and durability of the plated surface.
Octaquest E 30 helps to control metal ion concentrations and optimize deposition conditions, resulting in enhanced adhesion, corrosion resistance, and overall performance.
Octaquest E 30 is characterized by the presence of two carboxylic acid groups and two succinic acid moieties, which are attached to the amino groups of ethylenediamine.

Octaquest E 30 is a versatile chelating agent that forms stable complexes with metal ions.
Octaquest E 30 is known for its ability to bind and solubilize a variety of metal ions, particularly those with a high affinity for oxygen, such as iron (Fe), copper (Cu), and zinc (Zn).
The chelation process involves the formation of coordination bonds between the metal ion and the carboxylic acid groups of Octaquest E 30.




USAGE AREAS:

-Biodegradability:

Octaquest E 30 is biodegradable, which is advantageous from an environmental standpoint compared to some other chelating agents that may persist in the environment.


-Metal Chelation:

Octaquest E 30 has a high affinity for metal ions and is used as a chelating agent in various applications.
Octaquest E 30 finds use in cleaning formulations, detergents, and industrial processes where metal ion control is important.


-Soil Remediation:

Octaquest E 30 is employed in soil remediation processes to enhance the mobilization and removal of heavy metals from contaminated soil.
Octaquest E 30 can improve the bioavailability and extraction of metal pollutants, aiding in their remediation.


-Personal Care and Cosmetics:

Octaquest E 30 is utilized in some personal care products and cosmetics as a chelating agent to stabilize formulations and improve the efficacy of preservatives.


-Industrial Processes:

Octaquest E 30 finds application in various industrial processes, such as metal plating, textile dyeing, and water treatment, where metal ion control and complexation are required.



PHYSICAL AND CHEMICAL PROPERTIES:

Appearance: white crystalline powder or solid
Molecular Formula: C10H16N2O8
Molecular Weight: 292.24 g/mol
Melting Point: 160-190°C



CHEMICAL PROPERTIES:

-Chelating Properties:

Octaquest E 30 is primarily known for its chelating properties.
Octaquest E 30 forms stable complexes with various metal ions, particularly those with a high affinity for oxygen, such as iron (Fe), copper (Cu), and zinc (Zn).
The chelation occurs through coordination bonds between the metal ion and the carboxylic acid groups of Octaquest E 30.


-pH Sensitivity:

The chelating effectiveness of Octaquest E 30 is influenced by pH.
Octaquest E 30 shows higher chelating capacity and stability in slightly acidic to neutral pH ranges.


-Biodegradability:

Octaquest E 30 is considered biodegradable, which means it can be broken down by natural processes in the environment over time.
This characteristic is advantageous from an environmental perspective.



SYNONYM:

L-Aspartic acid, N,N′-1,2-ethanediylbis-, sodium salt (1:3)
L-Aspartic acid, N,N′-1,2-ethanediylbis-, trisodium salt
(S,S)-Ethylenediamine disuccinic acid trisodium salt
(S,S)-Ethylenediamine-N,N′-disuccinic acid trisodium salt
Trisodium ethylenediamine-N,N-disuccinate
Ethylenediaminedisuccinate, trisodium
Octaquest E 30
[S,S]-EDDS trisodium salt
Ethylenediamine disuccinic acid trisodium salt
Natrlquest E 30
Chelest EDDS 35
Enviomet C 140
Trisodium ethylenediaminedisuccinate
EDDS-S 35





















OCTENIDINE DIHYDROCHLORIDE
Octenidine dihydrochloride is an antimicrobial agent that inhibits the growth of bacteria by interfering with their cell membrane.
Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.


CAS Number: 70775-75-6
EC Number: 274-861-8
MDL Number: MFCD01938808
Molecular Formula: C36H62N4 • 2 HCl


Octenidine Dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.
Octenidine Dihydrochloride is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative used in concentrations of 0.1-2.0% for skin, mucous membrane and wound antisepsis.


Octenidine Dihydrochloride is similar in its action to quaternary ammonium compounds, but is of somewhat broader spectrum of activity.
Octenidine is currently increasingly used in continental Europe as a substitute for quats or chlorhexidine in water- or alcohol-based skin, mucosa and wound antiseptics. In aqueous formulations, it is often potentiated with addition of 2-phenoxyethanol.


Octenidine dihydrochloride is an antimicrobial agent that inhibits the growth of bacteria by interfering with their cell membrane.
The antimicrobial activity of Octenidine Dihydrochloride is maintained when applied to the skin of the hands and feet of cynomolgus monkeys.
Aqueous Octenidine Dihydrochloride, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%.


A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine.
Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.


Octenidine Dihydrochloride is an antiseptic (topical).
Octenidine Dihydrochloride is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative.
Octenidine dihydrochloride has been shown to be effective against a number of gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae.


Octenidine dihydrochloride belongs to the group of bispyridines.
The active substance, Octenidine Dihydrochloride, has non-specific antimicrobial, antifungal and antiviral properties.
Octenidine Dihydrochloride is a cationic surfactant, with a gemini-surfactant structure, derived from pyridine.


Octenidine Dihydrochloride is active against Gram-positive and Gram-negative bacteria.
Octenidine dihydrochloride is active against Gram-positive and Gram-negative bacteria.
Octenidine Dihydrochloride is soluble in dimethyl sulfoxide and methanol.


Octenidine Dihydrochloride, an active ingredient prominently utilized in numerous antiseptic, antibacterial, and antifungal products, holds significant importance.
This quaternary ammonium compound, Octenidine Dihydrochloride, serves as the salt derived from octenidine and hydrochloric acid.



USES and APPLICATIONS of OCTENIDINE DIHYDROCHLORIDE:
Octenidine dihydrochloride has been shown to be effective against a number of gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae.
Octenidine Dihydrochloride has synergistic effects when combined with eugenol and is used in dental hygiene products.


Octenidine dihydrochloride also has some antimicrobial activity against gram-positive bacteria, such as Lactobacillus acidophilus and Streptococcus mutans.
Octenidine Dihydrochloride can be used in agrochemical preparations for controlling growth of pathogenic fungi on plants.
Octenidine dihydrochloride is used as a antiseptic for skin, mucous Membranes and wounds.


Octenidine dihydrochloride is used 0,1% Phenoxyethanol 2% Antiseptic Disinfectant Antibacterial Antifungal Antiviral Indications - treatment of scrapes, minor cuts and wounds - disinfection of the skin and mucous membranes - disinfection of the oral region - in pediatric treatment (e.g. care of the umbilical stump) - postoperative stitch cleaning - antiseptic treatment of minor surgical, sore and burn wounds - prior, during and after operations in the anogenital regions - for time-limited supportive antiseptic treatment of interdigital dermophytosis.


Octenidine Dihydrochloride is used action - pain-free, does not burn the skin- helps to inhibit the growth of bacteria.
Octenidine Dihydrochloride is suitable for infants and children- easy to use (economy spray)- gently cleanses.
Octenidine Dihydrochloride helps to keep the skin hygienically clean- the broad spectrum of antiseptic efficacy.


Octenidine dihydrochloride is a cationic surfactant, with antimicrobial activity against Gram-positive and Gram-negative bacteria.
Octenidine Dihydrochloride approved as a medicinal substance in several European countries and used for skin antisepsis in combination with aliphatic alcohols, e.g. propan-1-ol and propan-2-ol, or with detergents such as antiseptic soap.


Octenidine Dihydrochloride is also used for antisepsis on wounds and mucosa either as a single substance, as an approved combination of Octenidine and Phenoxyethanol.
Octenidine Dihydrochloride is virtually not absorbed via the skin or mucous membranes.


Because Octenidine Dihydrochloride is only approved and used topically and is virtually not absorbed, no systemic effects are to be expected.
Therefore, no further pharmacokinetic studies or studies on behalf of metabolism have been conducted.
Octenidine Dihydrochloride is easy and safe to handle, chemically stable, not inflammable, without resistance development, and low toxicity to man and the environment alike.


Octenidine Dihydrochloride's popularity among therapists and wound care specialists is based on good clinical results, easy and pain-free application, and local tolerance.
Besides readily available combinations with phenoxyethanol, mouth rinses, and vaginal applications, semi-fluid preparations and dressings are described.


Octenidine Dihydrochloride is intended for pharmaceutical applications.
Octenidine Dihydrochloride is intended for laboratory use only, and it is not meant for human consumption.
Octenidine Dihydrochloride is used as a antiseptic for skin, mucous Membranes and wounds.


Since 1987, Octenidine Dihydrochloride has been used primarily in Europe as an antiseptic prior to medical procedures, including on neonates.
Octenidine Dihydrochloride is well used to produce disinfectant on skin, mucous membranes and open wounds.
Octenidine Dihydrochloride is used for the treatment of wound infections and for disinfecting the skin and mucous membrane.


Indications of Octenidine Dihydrochloride: Antiseptics and disinfectants, Gynecological anti-infectives and antiseptics
Octenidine Dihydrochloride is used as a antiseptic for skin, mucous Membranes and wounds.
Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.


Widely recognized for its exceptional antiseptic and antifungal properties, Octenidine Dihydrochloride finds extensive application in medical, industrial, and even food and cosmetic realms.
In-depth research into Octenidine Dihydrochloride has shed light on its remarkable biochemical and physiological effects.


Octenidine Dihydrochloride's efficacy in eradicating bacteria, fungi, and certain viruses has been demonstrated conclusively.
Acting as an antiseptic, Octenidine Dihydrochloride disrupts the microorganism′s cell membrane, impairs vital metabolic pathways, and interferes with essential protein synthesis.


Furthermore, Octenidine Dihydrochloride exhibits potent fungicidal activity and hampers the formation of biofilms.
Moreover, Octenidine Dihydrochloride exhibits anti-inflammatory and analgesic properties, providing relief from inflammation and pain.
Within the domain of scientific investigation, Octenidine Dihydrochloride has been subject to extensive in vitro studies.


Octenidine Dihydrochloride's efficacy in treating bacterial and fungal infections has been explored, showcasing its effectiveness against both gram-positive and gram-negative bacteria.
Moreover, researchers have evaluated Octenidine Dihydrochloride's potential as a combatant against viruses, revealing its favorable outcomes in combating select viral strains.


The versatile nature and proven efficacy of Octenidine Dihydrochloride have propelled its widespread utilization.
As a key component in various antiseptic, antibacterial, and antifungal formulations, Octenidine Dihydrochloride continues to pave the way for innovative applications and promising advancements in multiple fields.


-Medical uses of Octenidine Dihydrochloride:
Since 1987, Octenidine Dihydrochloride has been used in Europe as an antiseptic, in concentrations of 0.1 to 2.0%.
Octenidine Dihydrochloride is a substitute for chlorhexidine, with respect to its slow action and concerns about the carcinogenic impurity 4-chloroaniline.
Octenidine Dihydrochloride preparations are less expensive than chlorhexidine and no resistance had been observed as of 2007.
They may contain the antiseptic phenoxyethanol.



IN VITRO:
Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min.
Staphylococcus epidermidis is the most susceptible of the test organisms, and E. coli and C. albicans are the least susceptible.



IN VIVO:
The antimicrobial activity of Octenidine Dihydrochloride is maintained when applied to the skin of the hands and feet of cynomolgus monkeys.
Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%.
A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine.



OCTENIDINE DIHYDROCHLORIDE AND ITS IMPURITIES:
Since 1987, octenidine has been used in Europe as an antiseptic, in concentrations of 0.1 to 2.0%.
It is a substitute for chlorhexidine, with respect to its slow action and concerns about the carcinogenic impurity 4-chloroaniline.
It is a cationic surfactant.Reference standards of Octenidine Dihydrochloride API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.



PHYSICAL and CHEMICAL PROPERTIES of OCTENIDINE DIHYDROCHLORIDE:
Appearance: Light yellow to white powder
Content: ≥ 98%
Melting point: 215-217℃
Formula: C36H62N4 • 2 HCl
Molecular weight: 623.83 g/mol
Molecular size: small
Controlled Substance: no
Precursor: no
CAS Number: 70775-75-6
Weight Average: 623.84
Monoisotopic: 622.4508035
Chemical Formula: C36H64Cl2N4
InChI Key: SMGTYJPMKXNQFY-UHFFFAOYSA-N
InChI: InChI=1S/C36H62N4.2ClH/c1-3-5-7-9-15-19-27-37-35-23-31-39(32-24-35)29-21-17-13-11-12-14-18-22-30-40-33-25-36(26-34-40)38-28-20-16-10-8-6-4-2;;/h23-26,31-34H,3-22,27-30H2,1-2H3;2*1H
IUPAC Name: N-(1-{10-[4-(octylimino)-1,4-dihydropyridin-1-yl]decyl}-1,4-dihydropyridin-4-ylidene)octan-1-amine dihydrochloride
SMILES: Cl.Cl.CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1

Water Solubility: 2.6e-05 mg/mL
logP: 8.23
logP: 11.06
logS: -7.3
pKa (Strongest Basic): 10.89
Physiological Charge: 2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 0
Polar Surface Area: 31.2 Å2
Rotatable Bond Count: 25
Refractivity: 179.43 m3·mol-1
Polarizability: 75.45 Å3
Number of Rings: 2
Bioavailability: 0
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Molecular Weight: 623.83

Appearance: Solid
Formula: C36H64Cl2N4
CAS No.: 70775-75-6
SMILES: CCCCCCCC/N=C1C=CN(CCCCCCCCCCN(C=C/2)C=CC2=N/CCCCCCCC)C=C/1.Cl.Cl
Storage: Store at -20°C
M.Wt: 623.83
Cas No.: 70775-75-6
Formula: C36H64Cl2N4
Solubility: ≥41.9 mg/mL in EtOH; ≥8.29 mg/mL in H2O with ultrasonic; ≥9.06 mg/mL in DMSO with ultrasonic
Chemical Name: N,N'-(1,1'-(decane-1,10-diyl)bis(pyridin-1(1H)-yl-4(1H)-ylidene))bis(octan-1-amine) dihydrochloride
Chemical formula C36H64Cl2N4
Melting Point: 214°C
Quantity: 1 g
Merck Index: 14,6754
Solubility Information: Soluble in dimethyl sulfoxide and methanol.
Formula Weight: 623.83
Percent Purity: 98%
Chemical Name or Material: Octenidine dihydrochloride
Molecular Formula / Molecular Weight: C36H62N4·2HCl = 623.84

Physical State (20 deg.C): Solid
Reaxys Registry Number: 5696466
PubChem Substance ID: 135727346
Merck Index (14): 6754
MDL Number: MFCD01938808
Min. Purity Spec: 98%
Physical Form (at 20°C): Solid
Melting Point: 208-217°C
Long-Term Storage: Store long-term in a cool, dry place
Appearance: White to Off-White Solid
Melting Point: >207ºC (dec.)
Molecular Weight: 623.83
Storage: 4°C, Hygroscopic
Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
Stability: Hygroscopic
Formula: C₃₆H₆₂N₄
MW: 623.84 g/mol
Melting Pt: 214 °C
Storage Temperature: Ambient
MDL Number: MFCD01938808
CAS Number: 70775-75-6
EINECS: 274-861-8



FIRST AID MEASURES of OCTENIDINE DIHYDROCHLORIDE:
-Description of first-aid measures:
*After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.



ACCIDENTAL RELEASE MEASURES of OCTENIDINE DIHYDROCHLORIDE:
-Environmental precautions:
No special precautionary measures necessary.
-Methods and materials for containment and cleaning up:
Observe possible material restrictions.
Take up with liquidabsorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of OCTENIDINE DIHYDROCHLORIDE:
-Extinguishing media:
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.



EXPOSURE CONTROLS/PERSONAL PROTECTION of OCTENIDINE DIHYDROCHLORIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
not required
*Respiratory protection:
Not required.
-Control of environmental exposure:
No special precautionary measures necessary.



HANDLING and STORAGE of OCTENIDINE DIHYDROCHLORIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of OCTENIDINE DIHYDROCHLORIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
N,N’-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride
Octenidine Dihydrochloride
1,1′-(Decane-1,10-diyl)bis(N-octylpyridin-4(1H)-imine)—hydrogen chloride (1/2)
N,N′-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride
N,N′-[Decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene]bis(octylammonium) dichloride
N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanamine Hydrochloride



OCTENIDINE HCL ( Octenidine dihydrochloride)
N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine dihydrochloride; N,N'-(decane-1,10-diyldipyridin-1-yl-4-ylidene)dioctan-1-amine dihydrochloride; N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride CAS NO:70775-75-6; 71251-02-0 (Octenidine)
OCTENIDINE HYDROCHLORIDE
Octenidine hydrochloride is a cationic surfactant, with a gemini-surfactant structure, derived from pyridine.
Octenidine hydrochloride is active against Gram-positive and Gram-negative bacteria.
Since 1987, Octenidine hydrochloride has been used primarily in Europe as an antiseptic prior to medical procedures, including on neonates.

CAS: 70775-75-6
MF: C36H64Cl2N4
MW: 623.82616
EINECS: 274-861-8

Octenidine hydrochloride is absorbed neither through the skin, nor through mucous membranes, nor via wounds and does not pass the placental barrier.
However, cation-active compounds cause local irritation and are extremely poisonous when administered parenterally.
In a 2016 in vitro study of mouth rinses on gingival fibroblasts and epithelial cells Octenidine hydrochloride showed a less cytotoxic effect, especially on epithelial cells, compared to chlorhexidine after 15 min.
Wound irrigation with Octenidine hydrochloride has caused severe complications in dogs, aseptic necrosis and chronic inflammation in penetrating hand wounds in humans.

Octenidine hydrochloride is a cationic surfactant, with antimicrobial activity against Gram-positive and Gram-negative bacteria.
Octenidine hydrochloride approved as a medicinal substance in several European countries and used for skin antisepsis in combination with aliphatic alcohols, e.g. propan-1-ol and propan-2-ol, or with detergents such as antiseptic soap.
Octenidine hydrochloride is also used for antisepsis on wounds and mucosa either as a single substance, as an approved combination of Octenidine and phenoxyethanol.

Octenidine hydrochloride is virtually not absorbed via the skin or mucous membranes.
Because Octenidine hydrochloride is only approved and used topically and is virtually not absorbed, no systemic effects are to be expected.
Therefore, no further pharmacokinetic studies or studies on behalf of metabolism have been conducted.
Octenidine hydrochloride is easy and safe to handle, chemically stable, not inflammable, without resistance development and low toxicity to man and the environment alike.
Octenidine hydrochloride's popularity among therapists and wound care specialists is based on good clinical results, easy and pain-free application and local tolerance.
Beside readily available combinations with phenoxyethanol, mouth rinses, and vaginal applications, semi-fluid preparations and dressings are described.

Medical uses
Since 1987, Octenidine hydrochloride has been used in Europe as an antiseptic, in concentrations of 0.1 to 2.0%.
Octenidine hydrochloride is a substitute for chlorhexidine, with respect to its slow action and concerns about the carcinogenic impurity 4-chloroaniline.
Octenidine hydrochloride preparations are less expensive than chlorhexidine and no resistance had been observed as of 2007.
They may contain the antiseptic phenoxyethanol.
Octenidine hydrochloride is not listed in the Annex V of authorized preservatives of the European Cosmetic Regulation 1223/2009.

Efficacy
Octenidine hydrochloride is active against Gram-positive and Gram-negative bacteria.
In vitro suspension tests with 5 minute exposure time have shown that octenidine requires lower effective concentrations than chlorhexidine to kill common bacteria like Staphylococcus aureus, Escherichia coli, Proteus mirabilis and the yeast Candida albicans.
An observational study of using octenidine on the skin of patients in 17 intensive care units in Berlin in 2014 showed decreasing nosocomial infection rates.

In a survey of German neonatal intensive-care units Octenidine hydrochloride without phenoxyethanol and octenidine were the most common skin antiseptics used for intensive-care procedures.
Skin complications included blistering, necrosis and scarring, which has not been previously reported in this population.

In a 2016 study of pediatric cancer patients with long-term central venous access devices using octenidine/isopropanol for the disinfection of catheter hubs and 3-way stopcocks as part of a bundled intervention, the risk of bloodstream infections decreased.

Synonyms
OCTENIDINE HYDROCHLORIDE
70775-75-6
Octenidine HCl
Sensidin do
Win 41464-2
Octenidine hydrochloride [USAN]
U84956NU4B
LAS189962
LAS-189962
WIN-41464-2
1,1'-(Decane-1,10-diyl)bis(N-octylpyridin-4(1H)-imine) dihydrochloride
N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine;dihydrochloride
Octenidine hydrochloride (USAN)
1,1'-Decamethylenebis(1,4-dihydro-4-(octylimino)pyridine) dihydrochloride
1-Octanamine, N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, dihydrochloride
CHEMBL36342
OCTENIDINE HCL [INCI]
SCHEMBL126065
UNII-U84956NU4B
HY-B2170A
Octenidine dihydrochloride
OCTILE METOXY CINNAMATE; 2-Ethylhexyl 4-methoxycinnamate; OMC; 2-Ethylhexyl cinnamate; 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethylhexyl ester; Octyl 4-methoxycinnamate; Eusolex® 2292; 3-(4-Methoxyphenyl)-2-propenoate; Octinoxate; Ethylhexyl p-methoxycinnamate; (5-Methylheptyl) 3-(4-methoxyphenyl)-2-propenoate; Octyl methoxycinnamate; cas no: 5466-77-3
OCTHILINONE
Octhilinone IUPAC Name 2-octyl-1,2-thiazol-3-one Octhilinone InChI 1S/C11H19NOS/c1-2-3-4-5-6-7-9-12-11(13)8-10-14-12/h8,10H,2-7,9H2,1H3 Octhilinone InChI Key JPMIIZHYYWMHDT-UHFFFAOYSA-N Octhilinone Canonical SMILES CCCCCCCCN1C(=O)C=CS1 Octhilinone Molecular Formula C11H19NOS Octhilinone CAS 26530-20-1 Octhilinone Related CAS 68480-30-8 (hydrochloride) Octhilinone Deprecated CAS 122667-23-6, 12673-72-2 Octhilinone European Community (EC) Number 247-761-7 Octhilinone UN Number 2922 Octhilinone UNII 4LFS24GD0V Octhilinone DSSTox Substance ID DTXSID1025805 Octhilinone Physical Description 2-octyl-3-isothiazolone is a clear dark amber liquid. Used as a fungicide. Octhilinone Color/Form Liquid Octhilinone Odor Very weak, sharp smell Octhilinone Boiling Point 248 °F at 0.01 mm Hg (NTP, 1992) Octhilinone Melting Point 15 °C at 101.325 kPa Octhilinone Flash Point greater than 200 °F (NTP, 1992) Octhilinone Solubility less than 1 mg/mL at 66° F (NTP, 1992) Octhilinone Density 1.04 at 60.3 °F Octhilinone Vapor Pressure 2.98 mm Hg at 77 °F Octhilinone LogP 2.45 (LogP) Octhilinone Stability/Shelf Life Stable under recommended storage conditions Octhilinone Decomposition When heated to decomposition it emits very toxic fumes of /sulfur oxides and nitrogen oxides/. Octhilinone Viscosity 48.04 sq mm.s at 20 °C; 17.94 sq mm.s at 30 °C Octhilinone pH pH = 3.4 Octhilinone Other Experimental Properties BP: 120 °C at 0.01 mm Hg Octhilinone Molecular Weight 213.34 g/mol Octhilinone XLogP3-AA 3.5 Octhilinone Hydrogen Bond Donor Count 0 Octhilinone Hydrogen Bond Acceptor Count 2 Octhilinone Rotatable Bond Count 7 Octhilinone Exact Mass 213.118735 g/mol Octhilinone Monoisotopic Mass 213.118735 g/mol Octhilinone Topological Polar Surface Area 45.6 Ų Octhilinone Heavy Atom Count 14 Octhilinone Formal Charge 0 Octhilinone Complexity 204 Octhilinone Isotope Atom Count 0 Octhilinone Defined Atom Stereocenter Count 0 Octhilinone Undefined Atom Stereocenter Count 0 Octhilinone Defined Bond Stereocenter Count 0 Octhilinone Undefined Bond Stereocenter Count 0 Octhilinone Covalently-Bonded Unit Count 1 Octhilinone Compound Is Canonicalized Yes Octhilinone is a member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group. A fungicide and antibacterial agent, it is used for treatment of canker and other fungal and bacterial diseases in fruit trees. It is no longer approved for use within the European Union. It has a role as an environmental contaminant, a xenobiotic, an antifungal agrochemical and an antibacterial agent.Octhilinone is a light golden yellow clear liquid. It has a very faint but sharp odor. It is moderately soluble in water. USE: Octhilinone is used as a bactericide and fungicide in agriculture, cooling tower water, paints, and leather. Its use as a materials preservative include fabrics and textiles, sealants, adhesives and rubber and plastics. EXPOSURE: Workers who use octhilinone may breathe in mists or have direct skin contact. The general population may have direct skin contact when using paint products containing octhilinone. If octhilinone is released to the environment, it will be broken down in air. Octhilinone released to air will also be in or on particles that eventually fall to the ground. It is not expected to be broken down by sunlight. It will not move into air from moist soil and water surfaces. It is expected to move slowly through soil. It will be broken down by microorganisms under certain conditions, and is not expected to build up in fish. RISK: Severe allergic reactions have been reported in some workers handling octhilinone or products containing this chemical, characterized by severe itching and rash over arms, legs and upper back. Allergic skin reactions have also been reported in individuals following non-occupational contact with products containing octhilinone. Additional data on the potential for octhilinone to cause toxic effects in humans were not available. Octhilinone causes moderate to severe irritation to the eyes and skin of laboratory animals, and can cause severe skin damage with direct contact. It is considered moderately toxic to animals following exposure by any route. Data on the potential for octhilinone to cause infertility in laboratory animals were not available. Increased abortion was observed in laboratory animals exposed to octhilinone at moderate-to-high oral doses that cause mothers to be sick (decreased weight gain, decreased appetite). Some mothers died. No birth defects were observed in offspring. Data on the potential for octhilinone to cause cancer in laboratory animals were not available. The potential for octhilinone to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC)For octhilinone (USEPA/OPP Pesticide Code: 099901) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses.As a materials preservative, OIT is used in industrial premises. There are no residential use sites for octhilinone as an active ingredient. However, octhilinone is used as a materials preservative in various end-use products, some of which can be handled and used in residential settings.Octhilinone can be prepared by reaction of dithio-N-n-dioctylpropionamide and sulfuryl chloride.The National Pesticide Information Retrieval System (NPIRS) identifies 15 companies with active labels for products containing the chemical octhilinone. To view the complete list of companies, product names and percent octhilinone in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.Octhilinone is found on List B. Case No: 2475; Pesticide type: fungicide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): 2-n-octyl-4-isothiazolin-3-one; Data Call-in (DCI) Date(s): 06/05/91, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.Octhilinone is used as fungicide, and biocide in cooling-tower water, paints, cutting oils, cosmetics and shampoo, as well as for leather preservation. HUMAN STUDIES: Severe allergic contact dermatitis from a paint mildewcide, octhilinone, developed in a worker formulating latex paints within a paint manufacturing company. An outbreak of severe itching, erythematous and edematous dermatitis over the extremities and upper back developed in 8 of 17 workers in the raw-materials department of a paint manufacturing factory. ANIMAL STUDIES: Guinea pig maximization testing demonstrated this to be a moderate sensitizer. No teratogenic response reported in developmental studies in rats. Octhilinone induced chromosomal aberrations in Chinese hamster ovary cells with and without metabolic activation.Octhilinone was tested to > 50% toxicity. No individual cell data. No significant increase in net nuclear grains/cell reported.The screening revealed that 2-octyl-4-isothiazolin-3-one (octhilinone) inhibited purified rat recombinant MGL (IC(50)= 88 +/- 12 nM) through a partially reversible mechanism. Initial structure-activity relationship studies showed that substitution of the n-octyl group of octhilinone with a more lipophilic oleoyl group increased inhibitor potency (IC(50)= 43 +/- 8 nM), while substitution with a methyl group produced the opposite effect (IC(50)= 239 +/- 68 nM). The inhibitory potency of octhilinone was selectively decreased by mutating cysteine 208 in MGL to glycine (IC(50); wild-type, 151 +/- 17 nM; C208G, 722 +/- 74 nM), but not by mutation of other cysteine residues (C32, C55, C201, C208 and C242). The results indicated that cysteine 208 plays an important role in MGL function and identified a novel class of isothiazolinone-based MGL inhibitors with nanomolar potency in vitro.Ochilinone's production may result in its release to the environment through various waste streams; its use as a plant wound protectant, fungicide/bactericide and cooling-tower biocide will result in its direct release to the environment. Octhilinone's production and use as a biocide in paints, cutting oils, and for leather preservation may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 3.68X10-5 mm Hg at 25 °C indicates octhilinone will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase octhilinone will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 10 hrs. Particulate-phase octhilinone will be removed from the atmosphere by wet and dry deposition. Octhilinone absorbs UV light at wavelength 280 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight since sunlight consists of wavelengths above 290 nm. If released to soil, octhilinone is expected to have low mobility based upon an estimated Koc of 840. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 2.1X10-8 atm-cu m/mole. Octhilinone is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Octhilinone was confirmed to be biodegradable using activated sludge in the Japanese MITI test suggesting that biodegradation is an important environmental fate process in soil. If released into water, octhilinone is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Octhilinone was 40-100% biodegraded in 4 weeks using the river die-away test indictating that biodegradation may be an important environmental fate process in water. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 19 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to octhilinone may occur through inhalation and dermal contact with this compound at workplaces where octhilinone is produced or used. Use data indicate that the general population may be exposed to octhilinone via dermal contact with consumer products containing octhilinone.Ochilinone's production may result in its release to the environment through various waste streams; its use as a plant wound protectant, fungicide/bactericide(1) and cooling-tower biocide(2,3) will result in its direct release to the environment(SRC). Octhilinone's production and use as a biocide in paints, cutting oils and for leather preservation(1) may result in its release to the environment through various waste streams(SRC).Based on a classification scheme(1), an estimated Koc value of 840(SRC), determined from a structure estimation method(2), indicates that octhilinone is expected to have very low mobility in soil(SRC). Volatilization of octhilinone from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.1X10-8 atm-cu m/mole(SRC), based upon its vapor pressure, 3.68X10-5 mm Hg(3), and water solubility, 500 mg/L(3). Octhilinone is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Octhilinone was confirmed to be biodegradable using activated sludge in the Japanese MITI test(4) suggesting that biodegradation is an important environmental fate process in soil.According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), octhilinone, which has a vapor pressure of 2.68X10-5 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase octhilinone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10 hrs(SRC), calculated from its rate constant of 4.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase octhilinone may be removed from the air by wet and dry deposition(SRC). Octhilinone absorbs UV light at wavelength 280 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight since sunlight consists of wavelengths above 290 nm.Octhilinone was confirmed to be biodegradable according to the standard test of the Japanese Ministry of Industry and Trade (MITI) that employs an inoculum obtained from sludge(1). Octhilinone, present at 1 mg/L, was 40-100% biodegraded in 4 weeks using the river die-away test(2). Biodegradation half-lives of 30 days, 360 hrs and 3,240 hours at 20 °C have been reported in soil, water and sediment, respectively(3).The rate constant for the vapor-phase reaction of octhilinone with photochemically-produced hydroxyl radicals has been estimated as 4.0X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 10 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A half-life in air of 3.3 hours has also been reported(2). The rate constant for the vapor-phase reaction of octhilinone with ozone has been estimated as 1.8X10-18 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(3). Octhilinone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). Octhilinone absorbs UV light at wavelength 280 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight since sunlight consists of wavelengths above 290 nm(SRC).Using a structure estimation method based on molecular connectivity indices(1), the Koc of octhilinone can be estimated to be 850(SRC). According to a classification scheme(2), this estimated Koc value suggests that octhilinone is expected to have low mobility in soil(SRC). A Koc of 179.8 at 20 °C has also been reported(3). Octhilinone, at a concentration of 10 ug/L, was <90% absorbed over 6 hours using a German municipal waste water treatment plant activated sludge in a bench-scale test(4).Octhilinone is a light golden yellow clear liquid. It has a very faint but sharp odor. It is moderately soluble in water. USE: Octhilinone is used as a bactericide and fungicide in agriculture, cooling tower water, paints, and leather. Its use as a materials preservative include fabrics and textiles, sealants, adhesives and rubber and plastics. EXPOSURE: Workers who use octhilinone may breathe in mists or have direct skin contact. The general population may have direct skin contact when using paint products containing octhilinone. If octhilinone is released to the environment, it will be broken down in air. Octhilinone released to air will also be in or on particles that eventually fall to the ground. It is not expected to be broken down by sunlight. It will not move into air from moist soil and water surfaces. It is expected to move slowly through soil. It will be broken down by microorganisms under certain conditions, and is not expected to build up in fish. RISK: Severe allergic reactions have been reported in some workers handling octhilinone or products containing this chemical, characterized by severe itching and rash over arms, legs and upper back. Allergic skin reactions have also been reported in individuals following non-occupational contact with products containing octhilinone. Additional data on the potential for octhilinone to cause toxic effects in humans were not available. Octhilinone causes moderate to severe irritation to the eyes and skin of laboratory animals, and can cause severe skin damage with direct contact. It is considered moderately toxic to animals following exposure by any route. Data on the potential for octhilinone to cause infertility in laboratory animals were not available. Increased abortion was observed in laboratory animals exposed to octhilinone at moderate-to-high oral doses that cause mothers to be sick (decreased weight gain, decreased appetite). Some mothers died. No birth defects were observed in offspring. Data on the potential for octhilinone to cause cancer in laboratory animals were not available. The potential for octhilinone to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens.For octhilinone (USEPA/OPP Pesticide Code: 099901) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses.Control of apple and pear canker and other fungal and bacterial diseases of top fruit and citrus fruit. Also promotes rapid wound callousing of treated wounds and pruning cuts.Mildewcide, microbiocide, fungicide and bacteriocide.OIT is used to control sapstain and mold on wood via high pressure spray to logs that are processed to formulate plywood.As a materials preservative, OIT is used in industrial premises. There are no residential use sites for octhilinone as an active ingredient. However, octhilinone is used as a materials preservative in various end-use products, some of which can be handled and used in residential settings.Biocide in cooling-tower water, paints, cutting oils, cosmetics and shampoo; for leather preservation.Octhilinone can be prepared by reaction of dithio-N-n-dioctylpropionamide and sulfuryl chloride.The National Pesticide Information Retrieval System (NPIRS) identifies 15 companies with active labels for products containing the chemical octhilinone. To view the complete list of companies, product names and percent octhilinone in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.Densil ND Antimicrobial (Arch Chemicals, Inc.): Active ingredient: diuron 15.0%; zinc pyrithione 10.0%; and octhilinone 3.0%.This paper describes the development of a multi-residue method for the determination of 36 emerging organic pollutants (26 biocides, 5 UV-filters and 5 benzothiazoles) in raw and treated wastewater, activated sludge and surface water using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The target analytes were enriched from water samples adjusted to pH 6 by solid-phase extraction (SPE) on Oasis HLB 200 mg cartridges and eluted with a mixture of methanol and acetone (60/40, v/v). Extraction of freeze-dried sludge samples was accomplished by pressurized liquid extraction (PLE) using a mixture of methanol and water (50/50, v/v) as extraction solvent followed by SPE. LC-tandem MS detection was compared using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) in positive and negative ionization mode. ESI exhibited strong ion suppression for most target analytes, while APCI was generally less susceptible to ion suppression but partially leading to ion enhancement of up to a factor of 10. In general, matrix effects could be compensated using stable isotope-labeled surrogate standards, indicated by relative recoveries ranging from 70% to 130%. In wastewater, activated sludge and surface water up to 33 analytes were detected. Maximum concentrations up to 5.1 and 3.9 ug/L were found in raw wastewater for the water-soluble UV-filters benzophenone-4 (BZP-4) and phenylbenz-imidazole sulfonic acid (PBSA), respectively. For the first time, the anti-dandruff climbazole was detected in raw wastewater and in activated sludge with concentrations as high as 1.4 ug/L and 1.2 ug/gTSS, respectively. Activated sludge is obviously a sink for four benzothiazoles and two isothiazolones, as concentrations were detected in activated sludge between 120 ng/gTSS (2-n-octyl-4-isothiazolin-3-one, OIT) to 330 ng/gTSS (benzothiazole-2-sulfonic acid, BTSA).Symptoms of exposure to this compound include irritation of the skin and severe irritation of the eyes. Corrosion also occurs. ACUTE/CHRONIC HAZARDS: This compound is corrosive to tissues. It is moderately toxic by skin contact and ingestion. When heated to decomposition it emits toxic fumes IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital.Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. Splash proof safety goggles should be worn while handling this chemical. Alternatively, a full face respirator, equipped as above, may be used to provide simultaneous eye and respiratory protection.Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).2-OCTYL-3-ISOTHIAZOLONE reacts as an isothiocyanate. Isothiocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat.The Agency has completed its assessment of the dietary, occupational, drinking water, and ecological risks associated with the use of pesticide products containing the active ingredient OIT /2-Octyl-3(2H)-isothiazolone/. Based on a review of these data and on public comments on the Agency's assessments for the active ingredient OIT, the Agency has sufficient information on the human health and ecological effects of OIT to make decisions as part of the tolerance reassessment process under FFDCA and reregistration process under FIFRA, as amended by FQPA. The Agency has determined that OIT-containing products are eligible for reregistration provided that: (i) current data gaps and confirmatory data needs are addressed; (ii) the risk mitigation measure outlined in this document is adopted; and (iii) label amendments are made to reflect this measure. Label changes are described in Section V. ... Based on its evaluation of OIT, the Agency has determined that OIT products, unless labeled and used as specified in this document, would present risks inconsistent with FIFRA. Accordingly, should a registrant fail to implement the risk mitigation measures identified in this document, the Agency may take regulatory action to address the risk concerns from the use of OIT. If all changes outlined in this document are incorporated into the product labels, then all current risks for OIT will be substantially mitigated for the purposes of this determination. Once an Endangered Species assessment is completed, further changes to these registrations may be necessary as explained in Section III of this document.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Octhilinone is found on List B. Case No: 2475; Pesticide type: fungicide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): 2-n-octyl-4-isothiazolin-3-one; Data Call-in (DCI) Date(s): 06/05/91, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.
OCTILE METOXY CINNAMATE
cas no 6197-30-4 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate; 2-cyano-3,3-diphenyl-2-propanoic acid, 2-ethylhexyl ester; 2-ethylhexyl alpha-cyano-beta-phenylcinnamate; Octocrilene; Sanduvor 3039; Uvinul 3039; 2-Ethylhexyl alpha-cyano-beta,beta'-diphenylacrylate;