Other Industries

3-Azahexane;Ethylpropylamine;Propylethylamine;Einecs 243-573-4;N-Ethylpropylamin;ethyl-propyl-amine;N-ETHYLPROPYLAMINE;N-Ethylpropanamine;n-ethyl-1-propanamin;N,N-Ethylpropylamine CAS No.20193-20-8

1-Ethyl-2-pyrrolidinone; NEP; 1-éthylpyrrolidine-2-one; 1-Ethylpyrrolidin-2-one; 1-Ethylpyrrolidin-2-on; 1-Etilpirrolidin-2-ona; N-Ethylpyrrolidone; N-Ethyl-2-pyrrolidinon; N-Ethylpyrrolidinone; cas no:2687-91-4

SYNONYMS Morpholine, 4-ethyl-; 4-Ethylmorpholine; CAS NO:100-74-3

SYNONYMS Morpholine, 4-ethyl-; 4-Ethylmorpholine; N-Ethylmorpholine CAS NO:100-74-3

N-Ethyl-n-butylamine Ethylbutylamine N-ethylbutan-1-amine N-Ethylbutylamine 1-Butanamine, N-ethyl- N-Butylethylamine Ethyl-n-butylamine Butyl(ethyl)amine Butylamine, N-ethyl- BUTYLETHYLAMINE N-Ethylbutanamine N-Butyl-N-ethylamine N-n-Butylethylamine butyl-ethyl-amine ethyl-butyl amine N-butyl-ethylamine N-ethyl-n-butyl-amine N-n-butyl-N-ethylamine N-Ethyl-normal-butylamine cas :13360-63-9

1-Bromobutane; 1-Butyl bromide; cas no : 109-65-9

N-HEXYL GLYCOL; Ethylene glycol mono-n-hexyl ether, 2-hexoxy-1-ethanol cas no: 112-25-4

Neutrol TE is colorless viscous liquid.
Neutrol TE is gentle, non-irritating and non-greasy pH adjuster.
Neutrol TE is formulated with the feature high alcohol compatibility to stimulate a pleasant, nonsticky sensation on the skin.

CAS Number: 102-60-3
EC Number: 203-041-4
MDL number: MFCD00004534
Linear Formula: [CH3CH(OH)CH2]2NCH2CH2N[CH2CH(OH)CH3]2
Chemical Formula: C14H32N2O4
INCI Name: Tetrahydroxypropyl Ethylenediamine

Neutrol TE is miscible with water, methanol, ethanol, toluene, ethylene glycol and perchloroethylene.
Neutrol TE is incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents and chloroformates.
Neutrol TE is an ideal neutralizing agent for gel formulations such as carbomer.

Neutrol TE forms very few nitrosamines when compared to other amine-containing bases.
Neutrol TE is colorless liquid.
Neutrol TE is colorless viscous liquid.

Neutrol TE exhibits high alcohol compatibility and gives the skin a non-sticky and comfortable feel.
Neutrol TE forms very few nitrosamines when compared to other amine-containing bases.
Neutrol TE is a reaction product of ethylenediamine with 4 moles of propylene oxide.

Neutrol TE is formulated with the feature high alcohol compatibility to stimulate a pleasant, nonsticky sensation on the skin.
Neutrol TE is a reaction product of ethylenediamine with 4 moles of propylene oxide.
This gel, Neutrol TE, is formulated with the feature high alcohol compatibility to stimulate a pleasant, nonsticky sensation on the skin.

At room temperature, Neutrol TE is clear soluble in water, alcohol, and propylene glycol.
Neutrol TE forms dull dispersions in mineral oils.
It has been demonstrated that the tendency of Neutrol TE to form nitrosamines is extremely slight if it is substituted for other bases that contain amines.

Neutrol TE is a derivative of Ethylenediamine here all hydrogens connected with nitrogens are replaced with four 2-hydroxypropyl groups.
Neutrol TE is particularly suited as a neutralizing agent for polymers in clear gel formulations and forms clear solutions with solvents like water, ethanol, isopropanol, and propylene glycol.

The gels formulated with Neutrol TE have excellent alcohol compatibility and have a pleasant non-tacky skin feeling.
In comparison to other bases containing amines, it could be proved that Neutrol TE shows a considerably lower tendency to form nitroamines.
Neutrol TE has been toxicologically tested with regard to cosmetic use.

Within the recommended applications and concentrations of Neutrol TE, no indications of toxicological risks were found.
Neutrol TE is gentle, non-irritating and non-greasy pH adjuster.
Neutrol TE is a substituted amine.

Neutrol TE is excellent antistatic, dispersing, anticorrosive, lubricating, cleansing, emulsifying, solubilizing abilities.
Neutrol TE is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 tonnes per annum.
Neutrol TE is biodegradable.

Neutrol TE is easily soluble in water, and the aqueous solution is weakly alkaline.
Neutrol TE is excellent antistatic, dispersing, anticorrosive, lubricating, cleansing, emulsifying, solubilizing abilities.
Neutrol TE is a chelating agent that binds with metal ions or metallic compounds, preventing them from adhering to a surface (such as skin, hair, or clothing) or causing contamination, such as in the case of trace amounts of iron.

USES and APPLICATIONS of NEUTROL TE:
Neutrol TE uses and applications include: Detergent polymer; for surface coatings; emulsions; paints; paper and leather finishes; water treatment; dispersant and scale inhibitor for oil field water treatment; binder for textiles; thickener for fabric laminates, textile printing pastes; antistat, binder, film-former in cosmetics; thickener, stabilizer for cosmetics, paints, inks, waxes, polishes, detergents, etc.; in food packaging adhesives; in paperpaperboard in contact with dry food.

Neutrol TE is a Polymers of two or more monomers consisting of acrylic acid, methacrylic acid, or their simple esters.
Neutrol TE is used Cosmetic, Water Treatment, Textiles, Adhesives, Detergent.
Neutrol TE is used as a catalyst in the production of urethane foams.

Neutrol TE acts as a complexing agent, plasticizer, surfactant solubilizer and curing agent for epoxy resin.
Neutrol TE is also used as a viscosity modifier and as an anti-bloating agent for cattle.
Neutrol TE is utilized in piezoelectric crystal detectors of sulfur dioxide and in additives for paint.

Neutrol TE serves as a biological buffer as well as reagent for manganese.
Further, Neutrol TE finds application in adhesives and sealant chemicals.
In addition to this, Neutrol TE is used as a cross-linking agent.

Neutrol TE is used as a catalyst in manufacturing urethane foams, epoxy resin curing agent, complexing agent, humectant, plasticizer, chelate, surfactant solubilizer, viscosity modifier, and intermediate.
Neutrol TE is also used as an anti-bloating agent for cattle.

Neutrol TE is used in piezoelectric crystal detectors
Neutrol TE is the most suitable neutralizing agent for gel formulations using carbomer, etc.
Neutrol TE is used for Face care, Body care, Make-up, Face and body hygiene, Hair care.

Neutrol TE is also used by the cosmetic industry in soap-making and in stearate creams.
Neutrol TE is used Antiperspirant/Deodorants, Body Care, Oral Care, Sun Care, and more.
These high-performing products enable the development of formulations that fulfill consumer’s needs.

Gels formulated with Neutrol TE feature high alcohol compatibility and stimulate a pleasant, non-sticky sensation on the skin.
Other applications for Neutrol TE in the cosmetic field are the manufacture of soap, the production of stearate cremes, and the neutralization of sunscreens that contain acid groups.

Neutrol TE is a neutralizing agent for carbomer resins.
Neutrol TE is used in the production of gels.
Neutrol TE finds application in formulating skin-, sun-, men-, mother- & baby-, body-, face and color care products.

Neutrol TE is also used in skin cleansing, hair care (hair coloring, shampoos, conditioners, styling products), self-tanning, liquid soaps and shower/bath products.
Neutrol TE is used neutralizing agent for carbomer resins, e.g. in the production of gels.

Neutrol TE is an eminently suitable neutralizing agent for carbomer resin.
For example: in the production of gels.
Neutrol TE is used Bath & Shower, Body Care, Eye Liner, Face Care, Foundations, Mascara, Skin Care, Skin Cleansing, Sun Care.

Neutrol TE is a neutralizing agent that is used for carbomer resins (e.g., in the production of gels).
Neutrol TE is a clear, viscous liquid that is commonly used in baby care and cleansing, body care, face cleansing, hair coloring, shower/bath products, styling, etc.

Neutrol TE is used for the manufacture of soap and stearate cremes.
Neutrol TE is used Skin Care, Cleanser, Sun Care, Mother and baby, Hair care, Shampoo and Conditioner, Styling product, Hair color, Bath and Body
Men, Skin care, Body care, Face Care, Self Tanning, Pet Care, Pet Care TSCA, and Pet Care DSL.

Neutrol TE is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Neutrol TE is used in the following products: coating products, adhesives and sealants, washing & cleaning products and cosmetics and personal care products.

Other release to the environment of Neutrol TE is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Neutrol TE is used in the following areas: agriculture, forestry and fishing.

Release to the environment of Neutrol TE can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release.

Neutrol TE is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

Neutrol TE can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and electrical batteries and accumulators.
Neutrol TE is used in the following products: coating products, adhesives and sealants and polymers.

Neutrol TE can be found in products with material based on: plastic used for toys and other articles intended for children’s use, including baby-bottles, plastic used for articles with intense direct dermal (skin) contact during normal use (e.g. handles, ball pens), plastic (e.g. food packaging and storage, toys, mobile phones) and wood (e.g. floors, furniture, toys).

Neutrol TE is used for the manufacture of: chemicals and plastic products.
Other release to the environment of Neutrol TE is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Neutrol TE is used in the following products: coating products, adhesives and sealants, adsorbents, air care products, anti-freeze products, metals, biocides (e.g. disinfectants, pest control products), fillers, putties, plasters, modelling clay and non-metal-surface treatment products.
Release to the environment of Neutrol TE can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles.

Neutrol TE is used in the following products: polymers and adhesives and sealants.
Neutrol TE is used in the following areas: formulation of mixtures and/or re-packaging.
Neutrol TE is used for the manufacture of: chemicals.

Release to the environment of Neutrol TE can occur from industrial use: for thermoplastic manufacture, in the production of articles, formulation of mixtures, formulation in materials and in processing aids at industrial sites.
Release to the environment of Neutrol TE can occur from industrial use: manufacturing of the substance, formulation of mixtures, and thermoplastic manufacture.

Neutrol TE is used metal complexing agent for electroless copper plating in circuit board manufacturing.
Neutrol TE is used crosslinking agent for polyurethane products.
Neutrol TE is used concrete water reducing agent raw materials.

Neutrol TE is used for a flux and cleaning agent.
Neutrol TE is used for synthetic rubber, antistatic agent, synthetic plastic stabilizer.
Neutrol TE is used as metal complexing agent, as scaling powder and cleaner in electroless copper PCB plating.

Neutrol TE is used as metal complexing agent, used as scaling powder and cleaner in electroless copper PCB plating.
Neutrol TE is a chelant and it is used in cosmetics to bind metal ions to prevent unwanted metal-reactions within the formulation which could have negative effects on stability, preservation and product performance.

In Colorants Neutrol TE helps to preserve the intended color result and product stability in case of metal ion exposure during manufacturing of the tint.
Neutrol TE is mainly used for electroless copper plating complexing agent.
Neutrol TE is used Chelating agent, solvent.

Neutrol TE is used for electroless copper plating in circuit board manufacturing.
Neutrol TE is mainly used for chemical copper plating complexing agent.
Metal complexing agent, Neutrol TE is used for electroless copper plating, flux and cleaning agent in circuit board manufacturing.

Neutrol TE is used as solvent.
Neutrol TE is used as cleansing agent.
Neutrol TE is used as emulsifying agent, dispersing agent.

Neutrol TE is used as corrosion inhibitor, lubricant.
Neutrol TE is used as antistatic agent.
Neutrol TE is used as chelating agent.

Neutrol TE is used as intermediate in organic synthesis.
Neutrol TE is used Chelating agent in personal care products
Neutrol TE is a complexing agent.
Cosmetic Uses of Neutrol TE: chelating agents

BENEFITS CLAIMS OF NEUTROL TE:
*Chelating
*Sun Protection
*Cleansing
*Self-Tanning
*Non-Irradiated
*Ease of Styling
*After-Sun Repair

FUNCTIONS OF NEUTROL TE:
*Scale Inhibitor
*Acid
*Dispersant
*Stabilizer
*pH adjuster / buffer
*Neutralizing Agent

ALTERNATIVE PARENTS OF NEUTROL TE:
*Trialkylamines
*Secondary alcohols
*Organopnictogen compounds
*Hydrocarbon derivatives

SUBSTITUENTS OF NEUTROL TE:
*Tertiary aliphatic amine
*Tertiary amine
*Secondary alcohol
*1,2-aminoalcohol
*Organic oxygen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organooxygen compound
*Alcohol
*Aliphatic acyclic compound

WHAT DOES NEUTROL TE DO IN A FORMULATION?
*Chelating

FUNCTIONS OF NEUTROL TE:
*Chelating agent:
Neutrol TE reacts and forms complexes with metal ions which could affect the stability and/or appearance of cosmetic products

PHYSICAL and CHEMICAL PROPERTIES of NEUTROL TE:
Physical state: viscous
Color: colorless
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: 175 - 181 °C at 1 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 211 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility soluble
Partition coefficient: n-octanol/water
log Pow: -2,08 at 25 °C
Vapor pressure: 0,000011 hPa at 20 °C
Density: 1,013 g/mL at 25 °C

Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Surface tension: 63,94 mN/m at 20 °C
Water Solubility: 79.4 g/L
logP: -0.66, logP: -0.89, logS: -0.57
pKa (Strongest Acidic): 14.69
pKa (Strongest Basic): 9.5
Physiological Charge: 1
Hydrogen Acceptor Count: 6
Hydrogen Donor Count: 4
Polar Surface Area: 87.4 Å²
Rotatable Bond Count: 11
Refractivity: 80.85 m³·mol⁻¹

Polarizability: 33.93 Å³
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule
Density: 1.03
Boiling Point: 240°C (10mmHg)
Flash Point: >110°C (230°F)
Odor: Odorless
Refractive Index: 1.48
Merck Index: 14,3599
Solubility Information: Miscible with water,methanol,ethanol,toluene,ethylene glycol and perchloroethylene.
Formula Weight: 292.42
Percent Purity: 99%
Chemical Name or Material: N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Molecular Weight: 292.41 g/mol

XLogP3-AA: -0.7
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 11
Exact Mass: 292.23620751 g/mol
Monoisotopic Mass: 292.23620751 g/mol
Topological Polar Surface Area: 87.4Å²
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 199
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 4
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 1e+006 mg/L @ 25 °C (est)
Formula: C14h32n2o4
CAS No.: 102-60-3
EINECS: 203-041-4
Status: Liquid Catalyst
Response Type: Polymerization
Classification: Homogeneous Catalysts
Effect Size: Neutrol TE
Application: Industry
Appearance: Colorless to light yellow clear liquid
Assay: 99%min.
Appearance: Colorless to light yellow clear liquid
Assay: 99%min
Content of water: ≤0.15
pH value: 8.0-11.0
Solubility: Clear liquid
Melting point: 32°C
Boiling point: 175-181 °C0.8 mm Hg(lit.)
Density: 1.03 g/mL at 20 °C(lit.)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.4812(lit.)
Fp: >230 °F
Storage temp.: Store below 30°C.
PKA: 14.23±0.20(Predicted)
Specific Gravity: 1.013
PH: 10.4 (10g/l, H2O, 20℃)
Appearance: Colorless to light yellow viscous liquid
Colorless viscous liquid
PH Value, 1% water solution: 10.0 ~12.0
Effective content (%): 73.0 ~ 77.0
Color (Pt-Co): ≤ 30
Dynamic viscocity: (mPa’s, 25℃） 205 ~ 360
Proportion (g/cm3, 25℃）: 1.040 ~ 1.060
Solubility: 100% soluble in water

FIRST AID MEASURES of NEUTROL TE:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of NEUTROL TE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of NEUTROL TE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available

EXPOSURE CONTROLS/PERSONAL PROTECTION of NEUTROL TE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Safety glasses with side-shields.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 120 min
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of NEUTROL TE:
-Precautions for safe handling:
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.

STABILITY and REACTIVITY of NEUTROL TE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

SYNONYMS:
Edetol, Entprol, (Ethylenedinitrilo)tetra-2-propanol, Quadrol
102-60-3
203-041-4
1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL)
2-PROPANOL, 1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS-
EDETOL [HSDB]
EDETOL [INN]
EDETOL [USAN]
ENTPROL [MI]
N,N,N',N'-TETRAKIS (2-HYDROXYPROPYL) ETHYLENEDIAMINE
N,N,N',N'-TETRAKIS(2-HYDROXYPROPYL)ETHYLENEDIAMINE
NEUTROL TE
NSC-369219
QUADROL
TETRAHYDROXYPROPYL ETHYLENEDIAMINE
TETRAHYDROXYPROPYL ETHYLENEDIAMINE [INCI]
Quadrol
Edetol
Entprol
Neutrol TE
Quadrol
THPE
(Ethylenedinitrilo)tetra-2-propanol
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
1-({2-[Bis(2-hydroxypropyl)amino]ethyl}(2-hydroxypropyl)amino)propan-2-ol
1-{2-[Bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino}-2-propanol
1-{2-[Bis(2-oxidanylpropyl)amino]ethyl-(2-oxidanylpropyl)amino}propan-2-ol
Tetrahydroxypropyl ethylenediamine
Tetrahydroxypropyl ethylenediamine
Tetrakis(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-(Ethylenedinitrilo)tetra-2-propanol
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
1,1',1',1'''-(Ethylenedinitrilo)tetra-2-propanol
2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-
2-Propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-
Adeka Quadrol
ENTPROL
Entprol
N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Neutrol TE
Quadrol
Quadrol L
THPE
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol monotosylate
Quadrol
N,N,N',n'-tetrakis(2-hydroxypropyl)ethylenediamine
Tetrahydroxypropyl ethylenediamine
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol
2-Propanol,1,1',1'',1'''-(ethylenedinitrilo)tetra- (6CI,7CI,8CI)
1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetrakis[2-propanol]
1,1',1'',1'''-(Ethylenedinitrilo)tetra(2-propanol)
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
Adeka Quadrol
ENTPROL
EPD 300
Edetol
Laprol 294
N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
N,N,N',N'-Tetrakis(b-hydroxypropyl)ethylenediamine
NP 300
NSC 369219
Neutrol
Neutrol TE
Newpol NP 300
Quadrol
Quadrol L
THPE
Tetrakis(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL)
2-PROPANOL, 1,1',1'',1'''-(1,2- ETHANEDIYLDINITRILO)TETRAKIS-
EDETOL
EDETOL [HSDB]
EDETOL [INN]
EDETOL [USAN]
ENTPROL [MI]
N,N,N',N'-TETRAKIS (2-HYDROXYPROPYL) ETHYLENEDIAMINE
N,N,N',N'-TETRAKIS( 2-HYDROXYPROPYL)ETHYLENEDIAMINE
NEUTROL TE
NSC-369219
QUADROL
TETRAHYDROXYPROPYL ETHYLENEDIAMINE
TETRAHYDROXYPROPYL ETHYLENEDIAMINE [INCI]
102-60-3
Edetol
Quadrol
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Entprol
Neutrol TE
Adeka Quadrol
Quadrol L
1,1',1'',1'''-(Ethylenedinitrilo)tetra-2-propanol
Tetrahydroxypropyl ethylenediamine
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
Edetolum [Latin]
1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol)
Edetol [USAN:INN]
Edetolum
NSC 369219
EDTP
N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-Ethylenedinitrilotetrapropan-2-ol
HSDB 5349
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
TETRAKIS(2-HYDROXYPROPYL)ETHYLENEDIAMINE
EINECS 203-041-4
NSC-369219
BRN 1781143
UNII-Q4R969U9FR
2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-
CCRIS 8275
Q4R969U9FR
DTXSID9026689
Ethylenediamine-N,N,N',N'-tetra-2-propanol
2-Propanol, 1',1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
C14H32N2O4
Edetol (USAN)
1,1',1'',1'''-(Ethanediylnitrilo)tetrakis(2-propanol)
NCGC00164339-02
EDETOL [USAN]
EC 203-041-4
4-04-00-01685 (Beilstein Handbook Reference)
1,1',1',1'''-(Ethylenedinitrilo)tetra-2-propanol
DTXCID806689
Ethylenedinitrilotetra-2-Propanol
N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine, 98%
2-Propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-
CAS-102-60-3
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
EDTP
1,1',1'',1'''-(ethane-1,2-diyldinitrilo)tetrapropan-2-ol
Quadrol(R)
(Ethylenedinitrilo)tetra-2-propanol
Neutrol TE (TN)
EDETOL [HSDB]
EDETOL [INN]
ENTPROL [MI]
SCHEMBL48412
MLS004773924
N,N,N,N-Tetrakis(2-Hydroxypropyl)- Ethylenediamine
CHEMBL1573178
CHEBI:193592
HMS3264C08
Pharmakon1600-01301023
HY-B2149
Tox21_112102
Tox21_201973
Tox21_300552
MFCD00004534
NSC369219
NSC760394
tetra(2-hydroxypropyl)ethylenediamine
1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))-tetrakis(propan-2-ol)
AKOS015892820
C14-H32-N2-O4
Tox21_112102_1
CCG-230630
NSC-760394
SB82446
Tetra (2-hydroxypropyl) ethylenediamine
NCGC00164339-01
NCGC00164339-03
NCGC00164339-04
NCGC00164339-05
NCGC00254289-01
NCGC00259522-01
BS-23689
SMR001600027
LS-122312
CS-0020301
FT-0626306
T0781
D03948
F71260
N(CCN(CC(C)O)CC(C)O)(CC(C)O)CC(C)O
NNN'N'-Tetrakis(2-Hydroxypropyl)ethylenediamine
TETRAHYDROXYPROPYL ETHYLENEDIAMINE [INCI]
Tetrakis-[N-(2-hydroxy-propyl)]-ethylenediamine
1,1',1'',1'''-ethylendinitrilotetrapropan-2-ol
A800588
J-000740
n,n,n',n'-tetrakis (2-hydroxypropyl) ethylenediamine
N,N,N',N'-tetrakis-(2-hydroxypropyl)ethylenediamine
N,N,N,N-Tetrakis(2-hydroxypropyl)ethylenediamine;EDTP
Q26841009
Ethylenedinitrilo)tetra-2-propanol, 1,1',1'',1'''-(
1, 1', 1'', 1'''- ethylenedinitrilotetrapropan- 2- ol
2-Propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis-
1,1',1'',1'''-(ethane-1,2-diylbis(azanetriyl))tetrapropan-2-ol
1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL)
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]-2-propanol
1-[2-[bis(2-oxidanylpropyl)amino]ethyl-(2-oxidanylpropyl)amino]propan-2-ol
2-propanol, 1,1', 1'', 1'''-(1,2-etanodiildinitrilo) tetraquis-
1,1'',1'''',1''''''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol)
N,N,N inverted exclamation marka,N inverted exclamation marka-Tetrakis(2-hydroxypropyl)ethylenediamine
Edetol [USAN:INN]; 1,1,1,1-(Ethylenedinitrilo)tetra-2-propanol
Entprol
Tetrakis(2-hydroxypropyl)ethylenediamine
2-Propanol, 1,1,1,1-(1,2-ethanediyldinitrilo)tetrakis-
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
THPE
Chemical Q75
EDTP Neutrol TE
Edetol [USAN:INN]; 1,1,1,1-(Ethylenedinitrilo)tetra-2-propanol
Entprol
Tetrakis(2-hydroxypropyl)ethylenediamine
2-Propanol, 1,1,1,1-(1,2-ethanediyldinitrilo)tetrakis-
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
THPE
Chemical Q75
EDTP Neutrol TE

N-Hance BF-13 Cationic Guar is a yellow or white powdered ingredient that is obtained from guar beans.
N-Hance BF-13 Cationic Guar is a quaternary polymer that provides the dual benefits of conditioning and viscosity build.
N-Hance BF-13 Cationic Guar is substantive to anionic surfaces such as skin and hair.

CAS Number: 65497-29-2
Molecular Formula: C6H16NO2.xCl.xUnspecified

Guar hydroxypropyl trimonium chloride,65497-29-2, Guar hydroxypropyl trimethyl ammonium chloride,Cationic Guar Gum,Guar Hydroxypropyltrimnonium Chlide,gumguar2-hydroxy-3-(trimethylammonio)-propylet,jaguarc13s,GUM GUAR 2-HYDROXY-3-(TRIMETHYLAMMONIO)&,cosmediaguarc261,Guar,2-hydroxy-3-trimethylammoniopropylether,chloride.

N-Hance BF-13 Cationic Guar is boron-free which differentiates it from typical cationic guars.
N-Hance BF-13 Cationic Guar is generally used in shampoos and other hair products where it acts as a conditioner and an anti-static agent.
N-Hance BF-13 Cationic Guar is also used in skin care products where it deeply conditions the skin.

The chemical formula of Guar hydroxypropyltrimonium chloride is C6H16NO2.
Further, N-Hance BF-13 Cationic Guar is used as a substitute for harsh silicones.
N-Hance BF-13 Cationic Guar acts as a film-forming agent: It forms a thin layer of film over the skin, hair and prevents them from the harmful effects of environmental aggressors.

N-Hance BF-13 Cationic Guar also helps in trapping moisture in the skin and hair and prevents the moisture from escaping, thus hydrating the skin and hair which makes them softer and smoother.
N-Hance BF-13 Cationic Guar by Ashland acts as a thickener and conditioning agent.
This quaternary polymer is a medium-cationic-substitution, high-molecular-weight polymer.

N-Hance BF-13 Cationic Guar is boron-free which differentiates it from typical cationic guars.
N-Hance BF-13 Cationic Guar is substantive to anionic surfaces such as skin and hair.
Upon dilution of the surfactants with water, the cationic guar will complex with the anionic surfactants.

The complex will deposit cosmetically effective levels of ingredients such as silicone or emollient oils onto hair and skin.
N-Hance BF-13 Cationic Guar is designed for use in shampoos and body washes.
N-Hance BF-13 Cationic Guar, commonly known as guar gum or guar conditioner, is a quaternary ammonium derivative of guar gum.

N-Hance BF-13 Cationic Guar itself is a natural substance derived from guar beans and is often used in various industries, including food, cosmetics, and personal care products.
N-Hance BF-13 Cationic Guar acts as an antistatic agent: It neutralizes the electrons generated through static electricity.
This helps in the easy combing of hair when wet and prevents the formation of knots.

N-Hance BF-13 Cationic Guar acts as a skin-conditioning agent: It makes the skin softer and smoother.
N-Hance BF-13 Cationic Guar absorbs moisture which keeps the skin hydrated and makes the skin cleaner.
By conditioning the skin N-Hance BF-13 Cationic Guar makes the skin look younger.

N-Hance BF-13 Cationic Guars are cationic polymers that provide the dual benefits of conditioning and thickening.
The cationic charge makes the product substantive to anionic surfaces such as skin and hair.
Many of the products in the N-Hance BF-13 Cationic Guar product line have a high molecular weight, water-soluble backbone and are effective viscosifiers in aqueous solutions and surfactant-based systems.

N-Hance BF-13 Cationic Guar acts as a viscosity controlling agent: N-Hance BF-13 Cationic Guar makes the product thicker and imparts a gel-like consistency to the products.
N-Hance BF-13 Cationic Guar is a hydroxypropylated cationic guar derivative that provides conditioning benefits.
The cationic charge of N-Hance BF-13 Cationic Guar interacts with keratin providing a conditioning effect on hair and skin and reducing the negative effects of soaps and surfactants.

N-Hance BF-13 Cationic Guar is also used in skin care products where it deeply conditions the skin.
The chemical formula of N-Hance BF-13 Cationic Guar is C6H16NO2.
Further, N-Hance BF-13 Cationic Guar is used as a substitute for harsh silicones.

The main function of N-Hance BF-13 Cationic Guar is to extend conditioning properties to hair care products.
N-Hance BF-13 Cationic Guar is also sometimes used in skin care products to achieve the same results.
N-Hance BF-13 Cationic Guar is a positively charged ingredient, that cancels the negative charge on hair causing it to have a static or become tangled.

This ingredient makes the hair silky smooth without weighing them down.
N-Hance BF-13 Cationic Guar nourishes the skin and also increases the viscosity of the formulations.
N-Hance BF-13 Cationic Guar is an organic compound that is a water-soluble quaternary ammonium derivative of guar gum.

N-Hance BF-13 Cationic Guar gives conditioning properties to shampoos and after-shampoo hair care products.
The effects of the cationic charge density, guar concentration in aqueous solution, and treatment time on bleached European hair have been studied.
A mechanical testing method has been successfully applied to determine the efficacy of cationic guars to improve the ease of combing.

The results were confirmed in a shampoo formulation on both virgin and bleached hair.
N-Hance BF-13 Cationic Guar is an organic compound.
N-Hance BF-13 Cationic Guar is a water-soluble quaternary ammonium derivative of guar gum.

N-Hance BF-13 Cationic Guar gives conditioning properties to shampoos and after-shampoo hair care products.
N-Hance BF-13 Cationic Guar is a white or yellow fine powder derived from guar beans.
N-Hance BF-13 Cationic Guar is a white or yellow fine powder derived from guar beans.

N-Hance BF-13 Cationic Guar is a kind of galactomannan, which is a polysaccharide.
The N-Hance BF-13 Cationic Guar comes from the guar plant, which is a legume.
Major world suppliers include India, Pakistan, and the United States, as well as Australia and Africa.

The plant’s bean has a large endosperm, which is the part of the seed that acts as a food store for the developing plant.
Much of that endosperm contains N-Hance BF-13 Cationic Guar, which forms a viscous gel called guar gum when mixed with cold water.
N-Hance BF-13 Cationic Guar is a kind of galactomannan, which is a polysaccharide.

N-Hance BF-13 Cationic Guar comes from the guar plant, which is a legume.
N-Hance BF-13 Cationic Guar is a water-soluble, organic compound that is a quaternary ammonium derivative of guar (aka cluster beans).
N-Hance BF-13 Cationic Guar is a substance whose chemical structure has four carbon groups attached to a positively charged nitrogen atom.

N-Hance BF-13 Cationic Guar is widely used in hair care products, such as shampoos and conditioners, as a conditioning agent.
N-Hance BF-13 Cationic Guar is cationic nature allows it to adhere to the hair shaft, providing a smooth and conditioned feel to the hair.

In addition to its conditioning properties, N-Hance BF-13 Cationic Guar acts as a thickening agent in cosmetic formulations.
N-Hance BF-13 Cationic Guar helps improve the viscosity of products, contributing to their texture and consistency.
The cationic nature of N-Hance BF-13 Cationic Guar helps in detangling hair, making it easier to comb and manage.

This is particularly beneficial in leave-in conditioners and hair styling products.
N-Hance BF-13 Cationic Guar helps reduce static electricity in the hair, contributing to a smoother and more manageable appearance.
N-Hance BF-13 Cationic Guar can also be found in certain skin care products, where it may contribute to the formulation's texture and provide conditioning benefits.

This N-Hance BF-13 Cationic Guar is often compatible with a wide range of cosmetic ingredients and formulations, making it a versatile choice for personal care product development.
N-Hance BF-13 Cationic Guar is a quaternary ammonium derivative of guar gum.
N-Hance BF-13 Cationic Guar is used in hair conditioning products.

Although a great conditioning agent for both skin and hair, N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
Because it is positively charged, or cationic, N-Hance BF-13 Cationic Guar neutralizes the negative charges on hair strands that cause hair to become static or tangled.
Better yet, N-Hance BF-13 Cationic Guar does this without weighing hair down.

N-Hance BF-13 Cationic Guar is often used as an anti-static agent and skin or hair conditioner; it also increases viscosity.
N-Hance BF-13 Cationic Guar is also found in hundreds of personal care products, such as shampoo, conditioner, dandruff treatments, styling products, soap, hairspray, and other products.
N-Hance BF-13 Cationic Guar is a yellow or white powdered ingredient that is obtained from guar beans.

N-Hance BF-13 Cationic Guar acts as a film-forming agent:
N-Hance BF-13 Cationic Guar forms a thin layer of film over the skin, hair and prevents them from the harmful effects of environmental aggressors.
N-Hance BF-13 Cationic Guar acts as a skin-conditioning agent: It makes the skin softer and smoother.

N-Hance BF-13 Cationic Guar is a water-soluble, organic compound that is a quaternary ammonium derivative of guar (aka cluster beans).
This means it is a N-Hance BF-13 Cationic Guar whose chemical structure has four carbon groups attached to a positively charged nitrogen atom.
While plant derived, there is a synthetic portion to it.

N-Hance BF-13 Cationic Guar acts as a viscosity controlling agent: N-Hance BF-13 Cationic Guar is also used in skin care products where it deeply conditions the skin.
N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
N-Hance BF-13 Cationic Guar is a cationic polymer that can provide both conditioning and thickening effects.

N-Hance BF-13 Cationic Guar is high degree of cationic substitution and large molecular weight allow the polymer to adsorb on anionic surfaces (e.g., skin, hair).
Applicable to: conditioning shampoo (providing good dry and wet combing performance to make hair refreshing and elegant); hand sanitizer, face wash and liquid soap (providing soft, smooth and moisturizing skin when dry and non-slippery when wet).
N-Hance BF-13 Cationic Guar is generally considered safe.

N-Hance BF-13 Cationic Guar can also be used in personal care products to thicken formulations and provide skinconditioning benefits.
N-Hance BF-13 Cationic Guar is a water-soluble ingredient that is derived from plant-based sources.
N-Hance BF-13 Cationic Guar is generally used in hair care products as it helps to reduce static while retaining volume.

N-Hance BF-13 Cationic Guar is most widely used in hair care products
N-Hance BF-13 Cationic Guar is an organic compound that is a water-soluble quaternary ammonium derivative of guar gum.

Melting point: >300 °C(lit.)
Density:1.3 g/mL at 25 °C(lit.)
Odor: at 100.00?%. odorless

N-Hance BF-13 Cationic Guar is a compound that is water soluble. Although a great conditioning agent for both hair and scalp, this compound most definitely gives the biggest benefits to your strands of hair.
The reason being is that N-Hance BF-13 Cationic Guar’s positively charged, also known as cationic.
This means that N-Hance BF-13 Cationic Guar neutralises the negative charges on hair strands that cause hair to become static or tangled.

The result, easier combing, reduced frizz and minimised flyaways.
N-Hance BF-13 Cationic Guar is also a lightweight ingredient as its often used in place of other anti-static ingredients that are heavier which weigh the hair down, which is especially an issue on finer hair.
Although N-Hance BF-13 Cationic Guar’s majority plant based, there is a synthetic portion to the ingredient.

N-Hance BF-13 Cationic Guars are harvested from the Guar Gum Bush.
This bush can be found in the likes of India and Pakistan,USA and even Australia and Africa.
N-Hance BF-13 Cationic Guar is identified as a white or yellow like powder.

N-Hance BF-13 Cationic Guar is a great conditioning agent for both skin and hair.
N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
N-Hance BF-13 Cationic Guar is generally considered safe.

N-Hance BF-13 Cationic Guar is a naturally derived cationic polymer that is commonly used as a conditioning agent in shampoos, cream rinse conditioners, shower gels, body washes, and skin cleanser formulas.
Derived from the N-Hance BF-13 Cationic Guar, the polymer's backbone is a Mannose-Galactose Polysaccharide that has been cauterized to enhance substantivity to hair and skin.
N-Hance BF-13 Cationic Guar is a yellow, free-flowing powder with a slight amine odor.

N-Hance BF-13 Cationic Guar is an organic compound that is a water-soluble quaternary ammonium derivative of guar gum.
N-Hance BF-13 Cationic Guar gives conditioning properties to shampoos and after-shampoo hair care products.
N-Hance BF-13 Cationic Guar is an organic compound with charged properties, derived from guar gum.

N-Hance BF-13 Cationic Guar is a domesticated legume crop, with most of of the world's production in India.
Cultivated plants grow to around 1 meter tall, with hairy stems and leaves.
The leaves, seed pods and seeds are all known to be edible, and are often cooked in curries.

Harvested seeds or 'guar beans' are dehusked, roasted, hydrated and ground to produce guar gum.
N-Hance BF-13 Cationic Guar has charged properties that make it especially useful in hair care formulations.
N-Hance BF-13 Cationic Guar is cationic (positively charged) and works by neutralizing the negative charges on hair strands that cause static and tangling.

N-Hance BF-13 Cationic Guar can also be used in personal care products to thicken formulations and provide skinconditioning benefits.
N-Hance BF-13 Cationic Guar is a conditioning ingredient that is used in both skincare and hair care products.
N-Hance BF-13 Cationic Guar is a chemical component found in cosmetic and personal care goods, particularly hair care products.

N-Hance BF-13 Cationic Guar is made from guar gum, a natural material obtained from the seeds of the guar plant.
N-Hance BF-13 Cationic Guar is generally used for conditioning and thickening.
N-Hance BF-13 Cationic Guar is a water-soluble ingredient that is derived from plant-based sources.

N-Hance BF-13 Cationic Guar is generally used in hair care products as it helps to reduce static while retaining volume.
N-Hance BF-13 Cationic Guar is a water-soluble ingredient that is derived from plant-based sources.
N-Hance BF-13 Cationic Guar is generally used in hair care products as it helps to reduce static while retaining volume.

N-Hance BF-13 Cationic Guar may sound like a mouthful, but it's a frequent ingredient in hair care and cosmetic products.
N-Hance BF-13 Cationic Guar should be noted that, like any other ingredient, some people may be sensitive to or allergic to N-Hance BF-13 Cationic Guar.
Always conduct a patch test before using a new product, and discontinue use if any adverse reactions occur.

N-Hance BF-13 Cationic Guar is a conditioning agent for both the skin and hair N-Hance BF-13 Cationic Guar helps to moisturize.
While N-Hance BF-13 Cationic Guar is sometimes used in skincare formulations it is more often used in hair care products.
N-Hance BF-13 Cationic Guar is most widely used in hair care products due to the added benefit of helping to reduce static between hair strands.

N-Hance BF-13 Cationic Guar is commonly used as a conditioning agent in shampoo formulations.
N-Hance BF-13 Cationic Guar forms a coacervate with anionic surfactants from the shampoo formulation upon dilution and deposits on the surface of hair providing conditioning in the form of reduced wet combing forces.
The dilution and deposition phenomenon occurs when the system is diluted below the critical micelle concentration of the shampoo surfactants, resulting in the formation of the insoluble coacervate.

The properties of the formed coacervate depend on a variety of characteristics of the polymer, including molecular weight and charge density, as well as the composition of surfactants and presence of electrolytes.
In addition, N-Hance BF-13 Cationic Guar has reported uses in liquid soap and body wash formulations, hair conditioners, hair styling products, and skin care preparations.

Uses:
N-Hance BF-13 Cationic Guar is an anti-irritant and anti-inflammatory that is also used as a thickening, conditioning, and anti-static agent.
N-Hance BF-13 Cationic Guar helps maintain a product’s smoothing action.
Some manufacturers cite it as also having skin-softening capabilities.

N-Hance BF-13 Cationic Guar imparts excellent skin conditioning in creams or lotions that otherwise may not be used on the face.
N-Hance BF-13 Cationic Guar adds lubricity to a product when in contact with the skin.
There is some evidence that it can enhance a formulation’s viscosity and stability.

N-Hance BF-13 Cationic Guar is a derivative of guar gum.
Although a great conditioning agent for both skin and hair, N-Hance BF-13 Cationic Guar is especially beneficial as a hair care product.
Because it is positively charged, or cationic, it neutralizes the negative charges on hair strands that cause hair to become static or tangled.

Better yet, N-Hance BF-13 Cationic Guar does this without weighing hair down.
Typically used in formulations at 0.10% to 0.50% concentration levels, N-Hance BF-13 Cationic Guar is entirely compatible with most common anionic, cationic, and amphoteric surfactants and is ideally suited for use in two-in-one conditioning shampoos and moisturizing skin cleansing products.
When used in personal cleansing formulations, N-Hance BF-13 Cationic Guar imparts a soft, elegant after-feel to the skin.

Also, it enhances wet comb and dry comb properties in shampoos and hair conditioning systems.
Unlike similar ingredients, N-Hance BF-13 Cationic Guar is self-hydrating in water and does not require acidification during use.
N-Hance BF-13 Cationic Guar, one of the most widely used synthetic cationic polymers in the cosmetics industry, is an ingredient that’s often seen in conditioners and body washes.

N-Hance BF-13 Cationic Guar functions as a conditioning agent for skin and hair, helps deposit active ingredients on skin and/or hair, and also provides anti-static properties without weighing hair down.
N-Hance BF-13 Cationic Guar is a key ingredient in hair conditioners, providing a smooth and conditioned feel to the hair.
N-Hance BF-13 Cationic Guar helps in detangling and improving the manageability of hair.

N-Hance BF-13 Cationic Guar is often included in shampoos to enhance conditioning properties, reduce static, and improve the overall texture of the hair.
The thickening properties of N-Hance BF-13 Cationic Guar make it suitable for use in styling gels and creams, contributing to the desired texture and hold.
N-Hance BF-13 Cationic Guar is commonly used in leave-in conditioners to provide continuous conditioning throughout the day.

N-Hance BF-13 Cationic Guar helps in maintaining hair softness and manageability.
In intensive hair treatments and masks, N-Hance BF-13 Cationic Guar can enhance the conditioning effects, providing deep nourishment to the hair.
In some formulations, N-Hance BF-13 Cationic Guar may be included in body lotions and creams to contribute to the overall texture and skin feel.

In addition to regular conditioners, N-Hance BF-13 Cationic Guar can be included in intensive hair treatments, such as deep conditioning masks or overnight treatments, for enhanced hair nourishment.
Products designed to repair damaged hair may contain N-Hance BF-13 Cationic Guar to provide a reparative and conditioning effect to the hair shaft.
N-Hance BF-13 Cationic Guar can be added to hair gloss or shine sprays to enhance the overall shine and smoothness of the hair.

For hairstyles that require setting or styling, N-Hance BF-13 Cationic Guar can contribute to setting lotions, providing hold and manageability.
In texturizing products designed to create volume or texture in the hair, N-Hance BF-13 Cationic Guar may be used to enhance the product's consistency.
Products aimed at increasing hair volume, such as mousses or volumizing sprays, may include N-Hance BF-13 Cationic Guar to contribute to the overall formulation.

In cleansing conditioners or co-washes, where hair cleansing and conditioning are combined, N-Hance BF-13 Cationic Guar can play a role in providing conditioning benefits.
N-Hance BF-13 Cationic Guar may be incorporated into hair pomades or styling waxes to contribute to the product's texture and conditioning properties.
Products designed for textured or ethnic hair may contain N-Hance BF-13 Cationic Guar to address specific conditioning needs.

In hair care products formulated for color-treated hair, N-Hance BF-13 Cationic Guar can help maintain the vibrancy of the color while providing conditioning benefits.
As a naturally derived ingredient, N-Hance BF-13 Cationic Guar may be preferred in formulations that prioritize environmentally friendly and sustainable practices.
In certain cosmetic formulations, N-Hance BF-13 Cationic Guar may act as a stabilizer for fragrances, helping to maintain the integrity of the scent.

N-Hance BF-13 Cationic Guar is thickening properties make it suitable for use in liquid soaps and shower gels, contributing to their viscosity and texture.
In some facial cleansers, N-Hance BF-13 Cationic Guar may be used for its conditioning effects.
N-Hance BF-13 Cationic Guar is also found in some pet shampoos and grooming products to provide conditioning benefits for pets' fur.

N-Hance BF-13 Cationic Guar can be used in fabric softeners to provide a soft and conditioned feel to fabrics.
N-Hance BF-13 Cationic Guar is often included in hair serums to provide a lightweight conditioning effect, reducing frizz and enhancing the shine of the hair.
N-Hance BF-13 Cationic Guar can contribute to the formulation's overall texture and help in reducing static, providing a smooth finish.

Some hair color formulations may include N-Hance BF-13 Cationic Guar to improve the texture of the product and to provide conditioning benefits to the hair during and after the coloring process.
N-Hance BF-13 Cationic Guar is used in hair mousse formulations to contribute to the product's texture and provide conditioning effects while styling.
In certain sunscreen lotions or after-sun products, N-Hance BF-13 Cationic Guar may be added for its conditioning properties.

N-Hance BF-13 Cationic Guar can be found in hand lotions, contributing to the formulation's texture and providing a soft and conditioned feel to the skin.
In some deodorant formulations, N-Hance BF-13 Cationic Guar may be included to improve the product's texture and contribute to a smooth application.
Due to its detangling properties, N-Hance BF-13 Cationic Guar is used in hair detangling products to make combing or brushing easier and reduce hair breakage.

Some baby shampoos, lotions, and conditioners may contain N-Hance BF-13 Cationic Guar for its mild conditioning properties.
In certain wet wipe formulations, N-Hance BF-13 Cationic Guar may be used to provide a conditioning effect on the skin.
N-Hance BF-13 Cationic Guar can be included in various hair masks and treatments, providing deep conditioning benefits to nourish and revitalize the hair.

In general cosmetic preparations, such as creams and lotions, N-Hance BF-13 Cationic Guar may be added for its thickening and conditioning effects.
This is the second post in our series on conditioning ingredients.
N-Hance BF-13 Cationic Guar is used in Phique shampoo, as well as several other national brands.
The reason is its ability to make the hair feel smooth as well as target damaged areas that can make hair frizzy.

Safety profile:
Direct contact with the eyes may cause irritation.
In case of eye contact, N-Hance BF-13 Cationic Guar's important to rinse the eyes thoroughly with water.
If irritation persists, seek medical attention.

Some individuals may be sensitive or allergic to certain cosmetic ingredients, including N-Hance BF-13 Cationic Guar.
Skin testing should be conducted before applying products containing this ingredient extensively, especially for individuals with known skin sensitivities.
Inhalation of the dust or aerosolized form of the substance may cause respiratory irritation.

Adequate ventilation should be maintained in areas where the substance is handled in powder form.
While cosmetic products are not intended for ingestion, accidental swallowing may occur.
Ingestion of N-Hance BF-13 Cationic Guar is generally considered low risk, but it's advisable to seek medical attention if it occurs.

N-Hance BF-13 Cationic Guar is a quaternary ammonium compound, and excessive release into the environment can have environmental impacts.
N-Hance BF-13 Cationic Guar's important to follow proper disposal practices and adhere to environmental regulations.

N-HEPTANOIC ACID Bio-Based n-Heptanoic acid n-Heptanoic acid is a seven-carbon linear chain saturated fatty acid that can be used in the form of: Esters in the flavors and fragrances industry, in cosmetics and in industrial lubricants (aviation, refrigeration, automobile, etc.) Salts (sodium heptanoate) for corrosion inhibition Identity CAS number: 111-14-8 Chemical name: n-Heptanoic acid Common name: n-Heptylic acid, Oenanthic acid, Heptanoic acid Arkema is a Founding Member of Pragati: The World's First Sustainable Castor Program The goal of the Pragati project is to enable sustainable castor crop production. Scroll down to learn more about Pragati! Key Properties n-Heptanoic acid - CAS 111-14-8 Purity ≥ 99% 100% of vegetable oil origin (derived from castor oil) 100% linear and saturated carbon chain Chemical formula: CH3-(CH2)5-COOH Main Applications Thanks to its outstanding anti-corrosion properties and its unique performance level at high and low temperatures, bio-based Oleris® n-heptanoic acid is mainly used in lubricants in refrigeration/air conditioning, aviation, aerospace, automotive, etc. Also, it has interesting applications in the form of esters in the flavors and fragrances industry as well as in cosmetics. Lubricant Applications Seven carbon atoms in the linear chain yields a good balance in terms of low viscosity at low temperature and low volatility at high temperature. Gears of Titanium and Steel n-heptanoic acid is used in lubricants in the form of esters (e.g. neopolyol ester) with: Improved fluidity at low temperature, higher than with nearby C6/C8/C10 High thermal stability Good resistance to oxidation These esters are used primarily in applications for the automotive sector (car motor oils), in metalworking fluids, and as plasticizers etc. Flavors and Fragrances Applications n-Heptanoic acid, of 100% of vegetable origin (bio-based), is used as a chemical intermediate in the synthesis of esters from C1 to C9 alcohols. These esters present fruity, green, herbal or floral notes. Pink Perfume Bottles and Petals More than 25 aromatic esters from heptanoic acid are possible, like: In flavors: Ethyl heptanoate or allyl heptanoate with fruity or pineapple notes are commonly used In fragrances: Nonyl heptanoate is particulary appreciated for its orange floral rose notes Cosmetic Applications Brown Make-up Pencil n-Heptanoic acid is used as a chemical intermediate in the synthesis of bio-based cosmetics: Emollients Skin conditioning agents Viscosity controlling agents Like Stearyl heptanoate, Glyceryl triheptanoate, etc. INCI name: heptanoic acid Anti-corrosion Applications n-Heptanoic acid is a very effective corrosion inhibitor to protect copper, iron, aluminum and zinc when used as a salt derivative (sodium heptanoate). This heptanoic acid shows good stability in hard water which prevents the precipitation of calcium. Coatings This salt of heptanoic acid is widely used in: Metalworking fluids Water-based hydraulic fluids for anti-freeze application Industrial water-based refrigerants Temporary protection Anticorrosion additive for paints Cutting oils n-heptanoic acid certifications Ecocert Cosmetics logo n-heptanoic acid is Kosher certificated, free of BSE-TSE and is GMO free n-heptanoic acid is compliant with the raw materials standard that can be used in the formulation of cosmetics certified according to the Natural and Organic ECOCERT standard, and meets the specifications of the Food Chemical Codex, but is not intended for use as a direct food ingredient For industrial use only N-Heptanoic acid price More Price(18) Manufacturer Product number Product description CAS number Packaging Price Updated Buy Sigma-Aldrich 146870 N-Heptanoic acid 96% 111-14-8 100ml $29 2020-08-18 Buy Sigma-Aldrich 43858 N-Heptanoic acid analytical standard 111-14-8 1ml $73.5 2020-08-18 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 25mL $17 2020-06-24 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 500mL $53 2020-06-24 Buy Alfa Aesar A17704 N-Heptanoic acid, 98+% 111-14-8 500ml $55.4 2020-06-24 Buy N-Heptanoic acid Chemical Properties,Uses,Production Description As an organic compound, N-Heptanoic acid is a seven-carbon linear chain saturated fatty acid with an unpleasant, rancid and pungent odor, which is commonly used as a chemical intermediate in the synthesis of esters for products, such as ethyl heptanoate, that are used in fragrances and artificial flavors. It is also applied in cosmetics for the production of emollients, skin conditioning agents as well as viscosity controlling agents. Besides, N-Heptanoic acid can also act as a industrial lubricant applied in the fields of aviation, refrigeration, automobile, etc. due to its low viscosity at low temperature and low volatility at high temperature. Moreover, the good anti-corrosion property of N-Heptanoic acid results in the usage of metalworking fluids, industrial water-based refrigerants and anti-corrosion additive for paint. N-Heptanoic acid is also applied to esterify steroids in the field of pharmaceutical to produce drugs such as testosterone enanthate, trenbolone enanthate, drostanolone enanthate, methenolone enanthate and it is also one of numerous additives in cigarettes. References https://en.wikipedia.org/wiki/Heptanoic_acid https://pubchem.ncbi.nlm.nih.gov/compound/8094#section=Top http://www.arkema.com/en/products/product-finder/product-viewer/Oleris-n-Heptanoic-acid/ Description N-Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven - carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It contributes to the odor of some rancid oils. It is slightly soluble in water, but very soluble in ethanol and ether. Chemical Properties N-Heptanoic acid has a disagreeable rancid odor. The spectroscopically pure acid exhibits a faint tallow-like odor. N-Heptanoic acid may be prepared by oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Chemical Properties N-Heptanoic acid has a disagreeable rancid, sour, sweat-like, fatty odor The spectroscopically pure acid exhibits a faint fallow-like odor. Chemical Properties colourless liquid with a pungent and rancid odour Occurrence Reported as occurring naturally in calamus, hops, Acacia dealbata, and Japanese peppermint and violet leaves; its presence in rancid oils has been observed Also reported found in passion fruit, mandarin orange peel oil, guava, apple, banana, grapes, papaya, raspberry, strawberry, kiwi, baked potato, sauerkraut, tomato, breads, cheeses, butter, milk, fsh, fsh oil, meats, chicken fat, pork fat, hop oil, beer, cognac, brandy, rum, grape wines, sherry, whiskies, sake, peated malt, cocoa, coffee, tea, soy protein, peanuts, pecans, coconut, beans, mushroom, fenugreek, mango, fgs, licorice, corn oil, shrimps, scallops and other sources Uses Intermediates of Liquid Crystals Uses There are two major uses for N-Heptanoic acid. One is in vinyl plasticizers that are used primarily in the automotive market.This market is expected to grow 3 to 4% per year with GNP.The second is in synthetic lubricants, where N-Heptanoic acid is used in polyol esters.The market for polyol esters is primarily for use in commercial and military jet turbine lubricants.There is a small market for these esters in the automotive lubricant area, but there has been limited acceptance of these products by automakers and the public.The growth of the polyol ester market is expected to track GNP, unless automakers change to support synthetics or unless there is an elevation of military activity. The use of N-Heptanoic acid in high-water metalworking fluids has grown in excess of 20% over the last several years.The amount of acid used in these products is small; therefore, a dramatic change from the traditional oil-based fluids would be required before there would be significant market impact. Definition ChEBI: A C7, straight-chain fatty acid that contributes to the odour of some rancid oils. Used in the preparation of esters for the fragrance industry, and as an additive in cigarettes. Production Methods The methyl ester of ricinoleic acid, obtained from castor bean oil is the main commercial precursor to N-Heptanoic acid. It is hydrolyzed to the methyl ester of [[undecenoic acid]] and heptanal, which is then air oxidized to the carboxylic acid. Approximately 20,000 tons were consumed in Europe and US in 1980. Ricinoleic acid is the main precursor to N-Heptanoic acid. N-Heptanoic acid is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. N-Heptanoic acid is used to esterify steroids in the preparation of drugs such as as testosterone enanthate, trenbolone enanthate, drostanolone enanthate and methenolone enanthate (Primobolan). It is also one of many additives in cigarettes. Preparation By oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Taste threshold values Taste characteristics at 5 ppm: waxy, cheesy, fruity, dirty and fatty. Synthesis Reference(s) Organic Syntheses, Coll. Vol. 2, p. 315, 1943 The Journal of Organic Chemistry, 58, p. 4745, 1993 Tetrahedron Letters, 21, p. 2181, 1980 DOI: 10.1016/S0040-4039(00)78992-1 General Description A colorless liquid with a pungent odor. Less dense than water and poorly soluble in water. Hence floats on water. Very corrosive. Contact may likely burn skin, eyes, and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Flash point near 200°F. Air & Water Reactions Slightly soluble in water. Reactivity Profile N-Heptanoic acid reacts exothermically with bases. Can react, particularly if moist, with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow if the acid remains dry. Corrodes or dissolves iron, steel, and aluminum parts and containers under ordinary conditions. Reacts with cyanide salts to generate gaseous hydrogen cyanide, particuarly if moist. May generate flammable and/or toxic gases with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts exothermically with carbonates and bicarbonates to generate a harmless gas (carbon dioxide). Can be oxidized exothermically by strong oxidizing agents and reduced exothermically by strong reducing agents. A wide variety of products is possible. May initiate polymerization reactions; may catalyze chemical reactions. Hazard Combustible. Health Hazard Harmful if swallowed, inhaled, or absorbed through skin. Extremely destructive to mucous membranes, upper respiratory tract, skin, and eyes. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Fire Hazard N-Heptanoic acid is probably combustible. N-Heptanoic acid Preparation Products And Raw materials Bio-Based n-Heptanoic acid n-Heptanoic acid is a seven-carbon linear chain saturated fatty acid that can be used in the form of: Esters in the flavors and fragrances industry, in cosmetics and in industrial lubricants (aviation, refrigeration, automobile, etc.) Salts (sodium heptanoate) for corrosion inhibition Identity CAS number: 111-14-8 Chemical name: n-Heptanoic acid Common name: n-Heptylic acid, Oenanthic acid, Heptanoic acid Arkema is a Founding Member of Pragati: The World's First Sustainable Castor Program The goal of the Pragati project is to enable sustainable castor crop production. Scroll down to learn more about Pragati! Key Properties n-Heptanoic acid - CAS 111-14-8 Purity ≥ 99% 100% of vegetable oil origin (derived from castor oil) 100% linear and saturated carbon chain Chemical formula: CH3-(CH2)5-COOH Main Applications Thanks to its outstanding anti-corrosion properties and its unique performance level at high and low temperatures, bio-based Oleris® n-heptanoic acid is mainly used in lubricants in refrigeration/air conditioning, aviation, aerospace, automotive, etc. Also, it has interesting applications in the form of esters in the flavors and fragrances industry as well as in cosmetics. Lubricant Applications Seven carbon atoms in the linear chain yields a good balance in terms of low viscosity at low temperature and low volatility at high temperature. Gears of Titanium and Steel n-heptanoic acid is used in lubricants in the form of esters (e.g. neopolyol ester) with: Improved fluidity at low temperature, higher than with nearby C6/C8/C10 High thermal stability Good resistance to oxidation These esters are used primarily in applications for the automotive sector (car motor oils), in metalworking fluids, and as plasticizers etc. Flavors and Fragrances Applications n-Heptanoic acid, of 100% of vegetable origin (bio-based), is used as a chemical intermediate in the synthesis of esters from C1 to C9 alcohols. These esters present fruity, green, herbal or floral notes. Pink Perfume Bottles and Petals More than 25 aromatic esters from heptanoic acid are possible, like: In flavors: Ethyl heptanoate or allyl heptanoate with fruity or pineapple notes are commonly used In fragrances: Nonyl heptanoate is particulary appreciated for its orange floral rose notes Cosmetic Applications Brown Make-up Pencil n-Heptanoic acid is used as a chemical intermediate in the synthesis of bio-based cosmetics: Emollients Skin conditioning agents Viscosity controlling agents Like Stearyl heptanoate, Glyceryl triheptanoate, etc. INCI name: heptanoic acid Anti-corrosion Applications n-Heptanoic acid is a very effective corrosion inhibitor to protect copper, iron, aluminum and zinc when used as a salt derivative (sodium heptanoate). This heptanoic acid shows good stability in hard water which prevents the precipitation of calcium. Coatings This salt of heptanoic acid is widely used in: Metalworking fluids Water-based hydraulic fluids for anti-freeze application Industrial water-based refrigerants Temporary protection Anticorrosion additive for paints Cutting oils n-heptanoic acid certifications Ecocert Cosmetics logo n-heptanoic acid is Kosher certificated, free of BSE-TSE and is GMO free n-heptanoic acid is compliant with the raw materials standard that can be used in the formulation of cosmetics certified according to the Natural and Organic ECOCERT standard, and meets the specifications of the Food Chemical Codex, but is not intended for use as a direct food ingredient For industrial use only N-Heptanoic acid price More Price(18) Manufacturer Product number Product description CAS number Packaging Price Updated Buy Sigma-Aldrich 146870 N-Heptanoic acid 96% 111-14-8 100ml $29 2020-08-18 Buy Sigma-Aldrich 43858 N-Heptanoic acid analytical standard 111-14-8 1ml $73.5 2020-08-18 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 25mL $17 2020-06-24 Buy TCI Chemical H0030 N-Heptanoic acid >98.0%(T) 111-14-8 500mL $53 2020-06-24 Buy Alfa Aesar A17704 N-Heptanoic acid, 98+% 111-14-8 500ml $55.4 2020-06-24 Buy N-Heptanoic acid Chemical Properties,Uses,Production Description As an organic compound, N-Heptanoic acid is a seven-carbon linear chain saturated fatty acid with an unpleasant, rancid and pungent odor, which is commonly used as a chemical intermediate in the synthesis of esters for products, such as ethyl heptanoate, that are used in fragrances and artificial flavors. It is also applied in cosmetics for the production of emollients, skin conditioning agents as well as viscosity controlling agents. Besides, N-Heptanoic acid can also act as a industrial lubricant applied in the fields of aviation, refrigeration, automobile, etc. due to its low viscosity at low temperature and low volatility at high temperature. Moreover, the good anti-corrosion property of N-Heptanoic acid results in the usage of metalworking fluids, industrial water-based refrigerants and anti-corrosion additive for paint. N-Heptanoic acid is also applied to esterify steroids in the field of pharmaceutical to produce drugs such as testosterone enanthate, trenbolone enanthate, drostanolone enanthate, methenolone enanthate and it is also one of numerous additives in cigarettes. References https://en.wikipedia.org/wiki/Heptanoic_acid https://pubchem.ncbi.nlm.nih.gov/compound/8094#section=Top http://www.arkema.com/en/products/product-finder/product-viewer/Oleris-n-Heptanoic-acid/ Description N-Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven - carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It contributes to the odor of some rancid oils. It is slightly soluble in water, but very soluble in ethanol and ether. Chemical Properties N-Heptanoic acid has a disagreeable rancid odor. The spectroscopically pure acid exhibits a faint tallow-like odor. N-Heptanoic acid may be prepared by oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Chemical Properties N-Heptanoic acid has a disagreeable rancid, sour, sweat-like, fatty odor The spectroscopically pure acid exhibits a faint fallow-like odor. Chemical Properties colourless liquid with a pungent and rancid odour Occurrence Reported as occurring naturally in calamus, hops, Acacia dealbata, and Japanese peppermint and violet leaves; its presence in rancid oils has been observed Also reported found in passion fruit, mandarin orange peel oil, guava, apple, banana, grapes, papaya, raspberry, strawberry, kiwi, baked potato, sauerkraut, tomato, breads, cheeses, butter, milk, fsh, fsh oil, meats, chicken fat, pork fat, hop oil, beer, cognac, brandy, rum, grape wines, sherry, whiskies, sake, peated malt, cocoa, coffee, tea, soy protein, peanuts, pecans, coconut, beans, mushroom, fenugreek, mango, fgs, licorice, corn oil, shrimps, scallops and other sources Uses Intermediates of Liquid Crystals Uses There are two major uses for N-Heptanoic acid. One is in vinyl plasticizers that are used primarily in the automotive market.This market is expected to grow 3 to 4% per year with GNP.The second is in synthetic lubricants, where N-Heptanoic acid is used in polyol esters.The market for polyol esters is primarily for use in commercial and military jet turbine lubricants.There is a small market for these esters in the automotive lubricant area, but there has been limited acceptance of these products by automakers and the public.The growth of the polyol ester market is expected to track GNP, unless automakers change to support synthetics or unless there is an elevation of military activity. The use of N-Heptanoic acid in high-water metalworking fluids has grown in excess of 20% over the last several years.The amount of acid used in these products is small; therefore, a dramatic change from the traditional oil-based fluids would be required before there would be significant market impact. Definition ChEBI: A C7, straight-chain fatty acid that contributes to the odour of some rancid oils. Used in the preparation of esters for the fragrance industry, and as an additive in cigarettes. Production Methods The methyl ester of ricinoleic acid, obtained from castor bean oil is the main commercial precursor to N-Heptanoic acid. It is hydrolyzed to the methyl ester of [[undecenoic acid]] and heptanal, which is then air oxidized to the carboxylic acid. Approximately 20,000 tons were consumed in Europe and US in 1980. Ricinoleic acid is the main precursor to N-Heptanoic acid. N-Heptanoic acid is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. N-Heptanoic acid is used to esterify steroids in the preparation of drugs such as as testosterone enanthate, trenbolone enanthate, drostanolone enanthate and methenolone enanthate (Primobolan). It is also one of many additives in cigarettes. Preparation By oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid. Taste threshold values Taste characteristics at 5 ppm: waxy, cheesy, fruity, dirty and fatty. Synthesis Reference(s) Organic Syntheses, Coll. Vol. 2, p. 315, 1943 The Journal of Organic Chemistry, 58, p. 4745, 1993 Tetrahedron Letters, 21, p. 2181, 1980 DOI: 10.1016/S0040-4039(00)78992-1 General Description A colorless liquid with a pungent odor. Less dense than water and poorly soluble in water. Hence floats on water. Very corrosive. Contact may likely burn skin, eyes, and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Flash point near 200°F. Air & Water Reactions Slightly soluble in water. Reactivity Profile N-Heptanoic acid reacts exothermically with bases. Can react, particularly if moist, with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow if the acid remains dry. Corrodes or dissolves iron, steel, and aluminum parts and containers under ordinary conditions. Reacts with cyanide salts to generate gaseous hydrogen cyanide, particuarly if moist. May generate flammable and/or toxic gases with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts exothermically with carbonates and bicarbonates to generate a harmless gas (carbon dioxide). Can be oxidized exothermically by strong oxidizing agents and reduced exothermically by strong reducing agents. A wide variety of products is possible. May initiate polymerization reactions; may catalyze chemical reactions. Hazard Combustible. Health Hazard Harmful if swallowed, inhaled, or absorbed through skin. Extremely destructive to mucous membranes, upper respiratory tract, skin, and eyes. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Fire Hazard N-Heptanoic acid is probably combustible. N-Heptanoic acid Preparation Products And Raw materials

N-Hexyl Cellosolve is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-Hexyl Cellosolve, as known 2-Hexoxyethanol or 2-(Hexyloxy)ethanol, is a glycol ether that has a chemical formula of C8H18O2.
N-Hexyl Cellosolve enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.

CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2

n-Hexyl Cellosolve is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-Hexyl Cellosolve has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, n-Hexyl Cellosolve provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
n-Hexyl Cellosolve has a high boiling point, slow evaporating solvent with excellent solvency characteristics.

n-Hexyl Cellosolve has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, n-Hexyl Cellosolve provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
n-Hexyl Cellosolve is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
n-Hexyl Cellosolve is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.

n-Hexyl Cellosolve's miscibility with water, however, is limited.
n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since n-Hexyl Cellosolve may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2,6-di-tert-butyl-para cresol (butylated hydroxytoluene – BHT).

n-Hexyl Cellosolve is a Glycol ether solvent.
n-Hexyl Cellosolve Solvent is a high boiling point, slow evaporating rate solvent with excellent solvencycharacteristics.
n-Hexyl Cellosolve has the characteristic structure of glycol ethers and contains both ether and alcohol functionalgroups in the same molecule.
N-Hexyl Cellosolve (Ethylene Glycol Monohexyl Ether), n°112-25-4 is measured by GC-FID.

N-Hexyl Cellosolve's vapour is heavier than air.
N-Hexyl Cellosolve is a colorless liquid with a slight ether odor and bitter taste.
N-Hexyl Cellosolve (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.

N-Hexyl Cellosolve is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-Hexyl Cellosolve is a colorless liquid with a slight ether-like odor and bitter taste.
Since N-Hexyl Cellosolve may react with the oxygen in the air to form peroxides.
N-Hexyl Cellosolve's miscibility with water, however, is limited.

USES and APPLICATIONS of N-HEXYL CELLOSOLVE:
As a result, n-Hexyl Cellosolve provides unique cleaning power for removal of both water-soluble andgreasy (water insoluble) soils.
N-Hexyl Cellosolve is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.
N-Hexyl Cellosolve is used as special solvent for coating and ink.

N-Hexyl Cellosolve can be used as solvent in specialty printing inks.
The linear hexyl portion of n-Hexyl Cellosolve provides excellent oilsolubility characteristics that make it useful in both consumer and industrial cleaner applications.
N-Hexyl Cellosolve can also be used in printing inks and cleaners.

N-Hexyl Cellosolve is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
N-Hexyl Cellosolve is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
N-Hexyl Cellosolve is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.

n-Hexyl Cellosolve plays an important role in specialty printing inks. Because of its limited water solubility andslow evaporation, n-Hexyl Cellosolve can be used in formulations for the silk screen process to prevent premature setting of the ink.
n-Hexyl Cellosolve is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.

N-Hexyl Cellosolve is used Industry, Scientific Research, Health, Environmental Protection, Agriculture
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.
N-Hexyl Cellosolve serves as a coalescing agent in cleaners and latex paints.
N-Hexyl Cellosolve is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.

N-Hexyl Cellosolve has excellent oil solubility, making it effective in household and industrial cleaning applications.
n-Hexyl Cellosolve is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
n-Hexyl Cellosolve is used as a high-boiling solvent.

n-Hexyl Cellosolve is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
n-Hexyl Cellosolve is used as a coalescing agent in latex paints and cleaners;
n-Hexyl Cellosolve is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.

n-Hexyl Cellosolve possesses high boiling point.
n-Hexyl Cellosolve exhibits very good solvency, superior oil solubility, and slow evaporation rate.
The linear hexyl portion of this provides excellent oil solubility characteristics that make n-Hexyl Cellosolve useful in both consumer and industrial cleaner applications.

n-Hexyl Cellosolve plays an important role in speciality printing inks.
Because of its limited water solubility and slow evaporation, n-Hexyl Cellosolve can be used in formulations for the silk screen process to prevent premature setting of the ink.
N-Hexyl Cellosolve can be used as coalescent for water-borne.

N-Hexyl Cellosolvecan be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
N-Hexyl Cellosolve also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.

N-Hexyl Cellosolve is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
N-Hexyl Cellosolve is used as a high-boiling solvent.
N-Hexyl Cellosolve is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.

N-Hexyl Cellosolve is used as a coalescing agent in latex paints and cleaners.
For instance, it improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, it greatly improves film formation and levelling.

N-Hexyl Cellosolve is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.
Other uses of N-Hexyl Cellosolve are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.

N-Hexyl Cellosolve is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
N-Hexyl Cellosolve is used as high-boiling solvent.
N-Hexyl Cellosolve can be used as primary solvent in solvent-based silk screen printing inks.

N-Hexyl Cellosolve can be used as a solvent in lacquers, paints, resins, dyes, oils and lubricants, as well as as a coupling and dispersant.
N-Hexyl Cellosolve can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
Usage of N-Hexyl Cellosolve: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents

Two solvents, N-Hexyl Cellosolve and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
N-Hexyl Cellosolve is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products

-Uses of n-Hexyl Cellosolve:
*Cosmetics
*Cleaners
*Textiles
*Waterborne coatings
*Cleaning
*Printing ink

-Applications of n-Hexyl Cellosolve:
• Specialty printing inks
• Coalescent for water-borne, latex-based coatings, coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
• Primary solvent in solvent-based silk screen printing inks

BENEFITS OF N-HEXYL CELLOSOLVE:
*High boiling point
*Slow evaporation rate
*Excellent solvency
*Great chemical stability
*Biodegradable
*Compatible with water and a number of organic solvents
*Waterborne coatings: excellent coalescing solvent for water-borne, latex-based coatings
*Cleaning: coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners and disinfectants
*Cleaning: low vapor pressure allows formulating opportunities to address volatile organic compound (VOC) concerns
*Printing ink: especially effective in printing ink formulations for the silk-screen process

ALTERNATIVE PARENTS of N-HEXYL CELLOSOLVE:
*Primary alcohols
*Hydrocarbon derivatives

SUBSTITUENTS of N-HEXYL CELLOSOLVE:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound

PHYSICAL and CHEMICAL PROPERTIES of N-HEXYL CELLOSOLVE:
Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -

Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Å²
Rotatable Bond Count: 7

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 Å³
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1

Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7
Exact Mass: 146.130679813
Monoisotopic Mass: 146.130679813
Topological Polar Surface Area: 29.5 Å²
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

FIRST AID MEASURES of N-HEXYL CELLOSOLVE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-HEXYL CELLOSOLVE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.

FIRE FIGHTING MEASURES of N-HEXYL CELLOSOLVE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-HEXYL CELLOSOLVE:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-HEXYL CELLOSOLVE:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.

STABILITY and REACTIVITY of N-HEXYL CELLOSOLVE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available

SYNONYMS:
2-(Hexyloxy)ethanol
Cellosolve, n-hexyl-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
Hexyl cellosolve
n-Hexyl cellosolve
C6E1
HEXYLGLYCOL
2-hexyloxyethanol
N-HEXYL CELLOSOLVE
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
ETHYLENE GLYCOL N-HEXYL ETHER
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
2-(Hexyloxy)ethanol;2-HEXOXYETHANOL
AC1L1QF7
AC1Q7D9E
Cellosolve, N-hexyl-
EGHE
Ethanol, 2-(hexyloxy)-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
H0343
Hexyl alcohol, ethoxylated
Hexyl cellosolve
Hexyl poly(oxyethylene) ether
Hexylglycol
Poly(oxy-1,2-ethanediyl), alpha-hexyl-omega-hydroxy-
SBB060173
alpha-Hexyl,omega-hydroxypoly(oxy-1,2-ethanediyl)
n-Hexyl cellosolve
2- (HEXYLOXY) ETHANOL
2-N-(HEXYLOXY) ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYL GLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethane
2-Hexoxyethanol
2-hexyloxy-ethano
Cell fluid, n-hexyl-
ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
glycol monohexyl ether
Hexyl cellosolvation
hexyl cellosolve
n-hexyl-cellosolv
Ethylene gyl carbon mono-N-hexyl ether
Diethylene glycol hexyl ether
2-((2-Hexyloxy)ethoxy)ethanol
Diethylene glycol mono(n-hexyl) ether
Hexol carbitol
Diethylene glycol monohexyl ether
n-Hexoxyethoxyethanol
n-Hexyl carbitol
2-((2-Hexyloxy)ethoxy)ethanol
2-(2-(hexyloxy)ethoxy)ethanol
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(Hexyloxy)ethanol
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
2-Hexyloxy-1-ethanol
Ethylene glycol n-hexyl ether
2-n-(Hexyloxy)ethanol
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
DSSTox_CID_6908
DSSTox_RID_78248
DSSTox_GSID_26908
31726-34-8
Ethanol, 2-hexyloxy-
Ethylene glycol-n-monohexyl ether
HSDB 5569
Hexyl alcohol, ethoxylated
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
Poly(oxy-1,2-ethanediyl), .alpha.-hexyl-.omega.-hydroxy-
ZINC2041054
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
LS-13544
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)

n-hexyl glycol is a glycol ether that has a chemical formula of C8H18O2.
n-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.

CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2 / C6H13OCH2CH2OH

n-hexyl glycol has a high boiling point, slow evaporating solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
n-hexyl glycol is soluble in alcohol and ether, water (9.46 g/L ).

n-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odour.
n-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
n-hexyl glycol's miscibility with water, however, is limited.

n-hexyl glycol enters into the typical reactions of alcohols, e.g. esterification, etherification, oxidation and the formation of alcoholates.
Like all other ethers, n-hexyl glycol may form peroxides if it comes into contact with atmospheric oxygen.
n-hexyl glycol possesses high boiling point.

n-hexyl glycol exhibits very good solvency, superior oil solubility, and slow evaporation rate.
n-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.

n-hexyl glycol is a slow evaporating solvent that partitions primarily into the polymer phase of a waterborne coating and reduces minimum filming temperature.
n-hexyl glycol is a high boiling point, slow-evaporating rate solvent with excellent solvency characteristics.

n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy soils.
n-hexyl glycol is useful in both consumer and industrial applications and plays an important role in specialty printing inks.
n-hexyl glycol can also go by the name of Hexyl Cellosolve.

n-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
As a result, n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.

n-hexyl glycol Solvent is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
n-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
n-hexyl glycol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 tonnes per annum.

USES and APPLICATIONS of n-HEXYL GLYCOL:
n-hexyl glycol is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.
n-hexyl glycol can be used with associative thickeners to enhance application properties such as brushability or roll application in high performance coatings.

n-hexyl glycol is a high boiling point, slow evaporating solvent with excellent solvency characteristics.
n-hexyl glycol may be used to coalesce waterborne latex coatings and to balance solvency and volatility in high solids coatings.
As a result, n-hexyl glycol provides unique cleaning power for the removal of both water-soluble and greasy (water-insoluble) soils.

The linear hexyl portion of n-hexyl glycol provides excellent oil solubility characteristics that make it useful in both consumer and industrial cleaner applications.
n-hexyl glycol plays an important role in specialty printing inks.

Because of its limited water solubility and slow evaporation, n-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.
n-hexyl glycol is used specialty printing inks

n-hexyl glycol is used coalescent for water-borne, latex-based coatings, coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
n-hexyl glycol is used primary solvent in solvent-based silk screen printing inks

As a result, n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of this provides excellent oil solubility characteristics that make n-hexyl glycol useful in both consumer and industrial cleaner applications.

n-hexyl glycol plays an important role in specialty printing inks.
Because of n-hexyl glycol limited water solubility and slow evaporation, it can be used in formulations for the silk screen process to prevent premature setting of the ink.

n-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
The structure of n-hexyl glycol provides a unique cleaning power that can remove a wider array of soils.
With the characteristic structures of glycol ethers, n-hexyl glycol contains ether and alcohol functional groups in the same molecule.

n-hexyl glycol is used in the production of cleaning products and as a diluent for printing inks.
Uses of n-hexyl glycol: Cosmetics, Cleaners, Textiles, Waterborne, coatings, Cleaning, and Printing ink
n-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.

n-hexyl glycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
n-hexyl glycol is used as high-boiling solvent.
n-hexyl glycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.

n-hexyl glycol serves as a coalescing agent in cleaners and latex paints.
Other uses of 2-Hexoxyethanol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.

n-hexyl glycol is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.
n-hexyl glycol possesses high boiling point.

n-hexyl glycol exhibits very good solvency, superior oil solubility, and slow evaporation rate.
n-hexyl glycol can be used as solvent in specialty printing inks.
n-hexyl glycol can be used as coalescent for water-borne.

n-hexyl glycol can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
n-hexyl glycol can be used as primary solvent in solvent-based silk screen printing inks.
n-hexyl glycol is used Coalescent for water-borne, latex-based coatings, Coupling agent and solvent in rust removers, hard surface cleaners and disinfectants, Specialty Printing Inks, Screen Printing Inks.

As a result, n-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of n-hexyl glycol provides excellent oil solubility characteristics that make it useful in both consumer and industrial cleaner applications.

n-hexyl glycol plays an important role in specialty printing inks.
Because of its limited water solubility and slow evaporation, n-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.

n-hexyl glycol can also be used in printing inks and cleaners.
n-hexyl glycol is mainly used as a solvent, flow promoter, and coalescent aid in the coatings industry and in printing inks and cleaners.
n-hexyl glycol is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay, lubricants and greases, adhesives and sealants, anti-freeze products, finger paints, washing & cleaning products and polishes and waxes.
Other release to the environment of n-hexyl glycol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay and polymers.
n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay and polymers.
Release to the environment of n-hexyl glycol can occur from industrial use: formulation of mixtures.

n-hexyl glycol is used for the manufacture of: chemicals.
Release to the environment of n-hexyl glycol can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates) and manufacturing of the substance.

n-hexyl glycol is used in the following products: coating products, fillers, putties, plasters, modelling clay and polymers.
Release to the environment of n-hexyl glycol can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

-n-hexyl glycol as biodegradable cleaning power:
As part of an n-hexyl glycol-proven portfolio of home and institutional care applications, a biodegradable glycol ether solvent removes both water-soluble and greasy, water-insoluble soils.

n-hexyl glycol maintains excellent solvency characteristics without compromising environmental standards, allowing for uniform diffusion and reduced defects due to solvent-pop and air entrapment in formulations.
The structure of n-hexyl glycol provides a unique cleaning power that can remove a wider array of soils.
With the characteristic structures of glycol ethers, n-hexyl glycol contains ether and alcohol functional groups in the same molecule.

-Applications of n-hexyl glycol:
• Solvent in specialty printing inks
• Coalescent for water-borne, latex-based coatings
• Coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
• Primary solvent in solvent-based silk screen printing inks

-Coatings industry uses of n-hexyl glycol:
By virtue of its good solvent power, the main applications of n-hexyl glycol are as a solvent, flow promoter and coalescent aid.
For instance, n-hexyl glycol improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, n-hexyl glycol greatly improves film formation and levelling.
n-hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.

BENEFITS OF n-HEXYL GLYCOL:
-High boiling point
-Slow evaporation rate
-Excellent solvency
-Great chemical stability
-Compatible with water and a number of organic solvents
-Waterborne coatings: excellent coalescing solvent for water-borne, latex-based coatings
-Cleaning: coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners and disinfectants
-Cleaning: low vapor pressure allows formulating opportunities to address volatile organic compound (VOC) concerns
-Printing ink: especially effective in printing ink formulations for the silk-screen process

PHYSICAL and CHEMICAL PROPERTIES of n-HEXYL GLYCOL:
Molecular Formula: C8H18O2
Molar Mass: 146.23
Density: 0.888g/mLat 20°C(lit.)
Melting Point: -45.1℃
Boling Point: 98-99°C 0,15mm
Flash Point: 98-99°C/0.15mm
Water Solubility: Soluble in alcohol and ether, water (9.46 g/L ).
Vapor Presure: 10 Pa at 20℃
Appearance: clear liquid
Color: Colorless to Light yellow
BRN: 1734691
pKa: 14.44±0.10(Predicted)
Storage Condition: -15°C
Refractive Index: n20/D 1.431
Molecular Weight: 146.23 g/mol
XLogP3: 1.9
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7

Exact Mass: 146.130679813 g/mol
Monoisotopic Mass: 146.130679813 g/mol
Topological Polar Surface Area: 29.5Å²
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical formula: C8H18O2
Molar mass: 146.230 g·mol−1
Appearance: Colorless hygroscopic liquid
Odor: Characteristic
Density: 0.89
Melting point: −45 °C (−49 °F; 228 K)
Boiling point: 208.3 °C (406.9 °F; 481.4 K)

Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.93400 to 0.93700 @ 20.00 °C.
Pounds per Gallon - (est).: 7.781 to 7.806
Refractive Index: 1.43600 to 1.43800 @ 20.00 °C.
Melting Point: -28.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 260.00 °C. @ 760.00 mm Hg
Vapor Pressure: 5.030000 mmHg @ 25.00 °C. (est)
Flash Point: 284.00 °F. TCC ( 140.00 °C. )
logP (o/w): 1.700
Soluble in: water, 1.70E+04 mg/L @ 20 °C (exp)
water, 5602 mg/L @ 25 °C (est)
Vapor Pressure: 0.05 mmHg (@20°C)
Surface Tension: 27.7 dynes/cm (@25°C)
Solubility in water: 0.9 g/100g (@20°C)
Flash Point: 210°F
Viscosity: 5.2 cP (@25°C)
Molecular weight: 146.2
Boiling Point: 406°F
Freezing Point: -49°F

Specific Heat: 2.296 J/g/°C (@25°C)
Auto Ignition Temp: 536°F
Specific gravity: 0.889 (20/20°C)
Evaporation Rate: <0.01
Refractive Index: 1.4290 (20 c)
Melting point: -45.1℃
Boiling point: 98-99°C 0,15mm
Density: 0.888 g/mL at 20 °C(lit.)
vapor pressure: 10 Pa at 20℃
refractive index: n20/D 1.431
Flash point: 98-99°C/0.15mm
storage temp.: -15°C
pka: 14.44±0.10(Predicted)
form: clear liquid
color: Colorless to Light yellow
Water Solubility: Soluble in alcohol and ether, water (9.46 g/L ).
BRN: 1734691
LogP: 1.97 at 25℃
CAS: 112-25-4
EINECS: 203-951-1
InChI: InChI=1/C12H26O.C2H6O2.C2H4/c1-3-5-7-9-11-13-12-10-8-6-4-2;3-1-2-4;1-2/h3-12H2,1-2H3;3-4H,1-2H2;1-2H2

FIRST AID MEASURES of n-HEXYL GLYCOL:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of n-HEXYL GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.

FIRE FIGHTING MEASURES of n-HEXYL GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of n-HEXYL GLYCOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of n-HEXYL GLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.

STABILITY and REACTIVITY of n-HEXYL GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available

SYNONYMS:
C6E1
HEXYLGLYCOL
2-hexyloxyethanol
N-HEXYL CELLOSOLVE
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
ETHYLENE GLYCOL N-HEXYL ETHER
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
N-HEXYL CELLOSOLVE
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
2-(Hexyloxy)ethanol
112-25-4
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
Ethylene glycol n-hexyl ether
2-Hexyloxy-1-ethanol
DTXSID1026908
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
31726-34-8
DTXCID606908
Ethanol, 2-hexyloxy-
2-(hexyloxy)ethan-1-ol
CAS-112-25-4
Ethylene glycol-n-monohexyl ether
HSDB 5569
2-n-(Hexyloxy)ethanol
EINECS 203-951-1
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
SCHEMBL24741
4-01-00-02383 (Beilstein Handbook Reference)
CHEMBL3188016
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
FT-0631642
H0343
EN300-114321
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)
n-Hexyl Cellosolve
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Glycol monohexyl ether
Hexyl cellosolve
2-(Hexyloxy)ethanol
2-Hexoxyethanol
Ethylene glycol mono-n-hexyl ether
Cellosolve, n-hexyl-
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
N-HEXYL CELLOSOLVE
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
2-(Hexyloxy)ethanol
2-HEXOXYETHANOL
AC1L1QF7
AC1Q7D9E
Cellosolve, N-hexyl-
EGHE
Ethanol, 2-(hexyloxy)-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
H0343
Hexyl alcohol, ethoxylated
Hexyl cellosolve
Hexyl poly(oxyethylene) ether
Hexylglycol
Poly(oxy-1,2-ethanediyl), alpha-hexyl-omega-hydroxy-
SBB060173
alpha-Hexyl,omega-hydroxypoly(oxy-1,2-ethanediyl)
n-Hexyl cellosolve
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
N-HEXYL CELLOSOLVE
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL

N-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.
N-hexyl glycol, as known 2-Hexoxyethanol or 2-(Hexyloxy)ethanol, is a glycol ether that has a chemical formula of C8H18O2.

CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2

N-hexyl glycol (Ethylene Glycol Monohexyl Ether), n°112-25-4 is measured by GC-FID.
N-hexyl glycol's vapour is heavier than air.
N-hexyl glycol is a colorless liquid with a slight ether odor and bitter taste.
N-hexyl glycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.

N-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-hexyl glycol's miscibility with water, however, is limited.

n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since N-hexyl glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2,6-di-tert-butyl-para cresol (butylated hydroxytoluene – BHT).
N-hexyl glycol is a colorless liquid with a slight ether-like odor and bitter taste

Since N-hexyl glycol may react with the oxygen in the air to form peroxides.
N-hexyl glycol's miscibility with water, however, is limited.
N-hexyl glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
N-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.

N-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-hexyl glycol is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.

As a result, N-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
N-hexyl glycol has a high boiling point, slow evaporating solvent with excellent solvency characteristics.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.

N-hexyl glycol is a Glycol ether solvent.
N-hexyl glycol Solvent is a high boiling point, slow evaporating rate solvent with excellent solvencycharacteristics.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functionalgroups in the same molecule.

USES and APPLICATIONS of N-HEXYL GLYCOL:
N-hexyl glycol is used Industry, Scientific Research, Health, Environmental Protection, Agriculture
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.
N-hexyl glycol serves as a coalescing agent in cleaners and latex paints.

N-hexyl glycol has excellent oil solubility, making it effective in household and industrial cleaning applications.
N-hexyl glycol is used as a high-boiling solvent.
N-hexyl glycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
N-hexyl glycol is used as a coalescing agent in latex paints and cleaners.

For instance, it improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, it greatly improves film formation and levelling.
N-hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.

N-hexyl glycol plays an important role in speciality printing inks.
Because of its limited water solubility and slow evaporation, N-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.

N-hexyl glycol can also be used in printing inks and cleaners.
Usage of N-hexyl glycol: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
N-hexyl glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
N-hexyl glycol is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.

N-hexyl glycol is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
Other uses of N-hexyl glycol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties, Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.

N-hexyl glycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
N-hexyl glycol is used as a coalescing agent in latex paints and cleaners;
N-hexyl glycol is used as solvent in specialty printing inks, coalescent for water-borne latex-based coatings, primary solvent in solvent-based silk screen printing inks.

N-hexyl glycol possesses high boiling point.
N-hexyl glycol exhibits very good solvency, superior oil solubility, and slow evaporation rate.
The linear hexyl portion of this provides excellent oil solubility characteristics that make N-hexyl glycol useful in both consumer and industrial cleaner applications.

N-hexyl glycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.
N-hexyl glycol is used as high-boiling solvent.
N-hexyl glycol can be used as a solvent in lacquers, paints, resins, dyes, oils and lubricants, as well as as a coupling and dispersant.

N-hexyl glycol can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
N-hexyl glycol can be used as coalescent for water-borne.
N-hexyl glycolcan be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.

N-hexyl glycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
N-hexyl glycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .

Two solvents, N-hexyl glycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
N-hexyl glycol is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products

N-hexyl glycol can be used as primary solvent in solvent-based silk screen printing inks.
N-hexyl glycol is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.
N-hexyl glycol is used as special solvent for coating and ink.

N-hexyl glycol can be used as solvent in specialty printing inks.
As a result, N-hexyl glycol provides unique cleaning power for removal of both water-soluble andgreasy (water insoluble) soils.
The linear hexyl portion of N-hexyl glycol provides excellent oilsolubility characteristics that make it useful in both consumer and industrial cleaner applications.

N-hexyl glycol plays an important role in specialty printing inks. Because of its limited water solubility andslow evaporation, N-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.
N-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.

N-hexyl glycol is used as solvents in specialty printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.
N-hexyl glycol is used as a high-boiling solvent.
N-hexyl glycol is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.

-Uses of N-hexyl glycol:
*Cosmetics
*Cleaners
*Textiles
*Waterborne coatings
*Cleaning
*Printing ink

-Applications of N-hexyl glycol:
• Specialty printing inks
• Coalescent for water-borne, latex-based coatings, coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
• Primary solvent in solvent-based silk screen printing inks

ALTERNATIVE PARENTS of N-HEXYL GLYCOL:
*Primary alcohols
*Hydrocarbon derivatives

SUBSTITUENTS of N-HEXYL GLYCOL:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound

PHYSICAL and CHEMICAL PROPERTIES of N-HEXYL GLYCOL:
Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -

Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Å²
Rotatable Bond Count: 7

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 Å³
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1

Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 7
Exact Mass: 146.130679813
Monoisotopic Mass: 146.130679813
Topological Polar Surface Area: 29.5 Å²
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 55.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

FIRST AID MEASURES of N-HEXYL GLYCOL:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-HEXYL GLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.

FIRE FIGHTING MEASURES of N-HEXYL GLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-HEXYL GLYCOL:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-HEXYL GLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.

STABILITY and REACTIVITY of N-HEXYL GLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available

SYNONYMS:
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether
2-(Hexyloxy)ethanol
Ethylene glycol monohexyl ether
2-Hexyloxyethanol
Ethanol, 2-(hexyloxy)-
2-HEXOXYETHANOL
Hexyl cellosolve
n-Hexyl cellosolve
Glycol monohexyl ether
Cellosolve, N-hexyl-
2-Hexyloxy-1-ethanol
Ethylene glycol n-hexyl ether
2-n-(Hexyloxy)ethanol
7P0O8282NR
Ethylene glycol mono-n-hexyl ether
DSSTox_CID_6908
DSSTox_RID_78248
DSSTox_GSID_26908
31726-34-8
Ethanol, 2-hexyloxy-
Ethylene glycol-n-monohexyl ether
HSDB 5569
Hexyl alcohol, ethoxylated
BRN 1734691
UNII-7P0O8282NR
2-hexyloxy-ethanol
MFCD00045997
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
Poly(oxy-1,2-ethanediyl), .alpha.-hexyl-.omega.-hydroxy-
ZINC2041054
Tox21_202105
Tox21_300545
AKOS009156771
NCGC00248089-01
NCGC00248089-02
NCGC00254448-01
NCGC00259654-01
LS-13544
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)
2-(Hexyloxy)ethanol
Cellosolve, n-hexyl-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
Hexyl cellosolve
n-Hexyl cellosolve
C6E1
HEXYLGLYCOL
2-hexyloxyethanol
N-HEXYL CELLOSOLVE
2-(hexyloxy)-ethano
N-HEXYLMONOOXYETHYLENE
ETHYLENE GLYCOL N-HEXYL ETHER
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
2-(Hexyloxy)ethanol;2-HEXOXYETHANOL
AC1L1QF7
AC1Q7D9E
Cellosolve, N-hexyl-
EGHE
Ethanol, 2-(hexyloxy)-
Ethanol, 2-hexyloxy-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
H0343
Hexyl alcohol, ethoxylated
Hexyl cellosolve
Hexyl poly(oxyethylene) ether
Hexylglycol
Poly(oxy-1,2-ethanediyl), alpha-hexyl-omega-hydroxy-
SBB060173
alpha-Hexyl,omega-hydroxypoly(oxy-1,2-ethanediyl)
n-Hexyl cellosolve
2- (HEXYLOXY) ETHANOL
2-N-(HEXYLOXY) ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYL GLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethane
2-Hexoxyethanol
2-hexyloxy-ethano
Cell fluid, n-hexyl-
ethylene glycol-n-monohexyl ether
Glycol monohexyl ether
glycol monohexyl ether
Hexyl cellosolvation
hexyl cellosolve
n-hexyl-cellosolv
Ethylene gyl carbon mono-N-hexyl ether
Diethylene glycol hexyl ether
2-((2-Hexyloxy)ethoxy)ethanol
Diethylene glycol mono(n-hexyl) ether
Hexol carbitol
Diethylene glycol monohexyl ether
n-Hexoxyethoxyethanol
n-Hexyl carbitol
2-((2-Hexyloxy)ethoxy)ethanol
2-(2-(hexyloxy)ethoxy)ethanol

DESCRIPTION:
N-hexyl glycol is Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
N-hexyl glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-hexyl glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.

CAS number: 112-25-4
EC number: 203-951-1
Molecular formula: C8H18O2
Molar mass: 146.23 g/mol

The miscibility of N-hexyl glycol with water, however, is limited.
N-hexyl glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since N-hexyl glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2.6-di-tert-butyl-para-cresol (butylated hydroxytoluene – BHT).

N-hexyl glycol Solvent is a high boiling point, slow evaporating rate solvent with excellent solvency characteristics.
N-hexyl glycol has the characteristic structure of glycol ethers and contains both ether and alcohol functional groups in the same molecule.

As a result, N-hexyl glycol provides unique cleaning power for removal of both water-soluble and greasy (water insoluble) soils.
The linear hexyl portion of N-hexyl glycol Solvent provides excellent oil solubility characteristics that make it useful in both consumer and industrial cleaner applications.

N-hexyl glycol Solvent plays an important role in specialty printing inks.
Because of its limited water solubility and slow evaporation, N-hexyl glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.

CHEMICAL AND PHYSICAL PROPERTIES OF N-HEXYL GLYCOL:
n-Hexylglycol 98.0 min. %
Water 0.1 max. %
Pt/Co color value: (Hazen) 10 max.
Acid value 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml: 200 – 212 °C
Density at 20 °C 0.887 – 0.890 g/cm3
Refractive index nD20: 1.428 – 1.430
Solidification point at 1013 hPa: - 42 °C (ice flakes)
Evaporation rate ether = 1 approx. 1200
Enthalpy of combustion (Δ Hc) at 25 °C: 33 136 kJ/kg
Enthalpy of vaporization (Δ Hv) at 25 °C: 475 kJ/kg
Enthalpy of vaporization (Δ Hv) at boiling point: 325 kJ/kg
Enthalpy of formation (Δ Hf) at 25 °C: - 3 776 kJ/kg
Dipole moment (µ): 2.08 D
Solubility Mass fraction of n-Hexylglycol in water 1.0 %
Water in Hexylglycol 18.8 %
Molecular Weight (g/mol) 146.2
Boiling Point @ 760 mmHg, 1.01 ar 208 °C (406 °F)
Flash Point (Setaflash Closed Cup) 91.5 °C (210°F)
Freezing Point -50 °C (-58°F)
Vapor pressure@ 20°C — extrapolated:
0.05 mmHg
0.01 kPa
Specific gravity (25/25°C) 0.889
Liquid Density @ 20°C 0.888 g/cm3 (7.41 lb/gal)
Vapor Density (air = 1) 5
Viscosity (cP or mPa•s @ 25°C) 4.5
Surface tension (dynes/cm or mN/m @ 20°C) 27.7 (neat product) 27.1 (25% aq. Sol’n)
Specific heat (J/g/°C @ 25°C) 2.296
Heat of vaporization (J/g) at normal boiling point 342.76
Net heat of combustion (kJ/g) — predicted @ 25°C 32.6
Autoignition temperature 225 °C (437 °F)
Evaporation rate (n-butyl acetate = 1.0) <0.01
Solubility, g/L or % @ 20°C
Solvent in water 9.46 g/L

APPLICATIONS OF N-HEXYL GLYCOL:
By virtue of its good solvent power, the main applications of N-Hexyl glycol are as a solvent, flow promoter and coalescent aid.
For instance, N-Hexyl glycol improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, N-Hexyl glycol greatly improves film formation and levelling.

N-Hexyl glycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders.
N-Hexyl glycol can also be used in printing inks and cleaners.

N-Hexyl glycol is be used as Solvent in specialty printing inks
N-Hexyl glycol is be used as Coalescent for water-borne, latex-based coatings
N-Hexyl glycol is be used as Coupling agent and solvent in household and industrial cleaners, rust removers, hard surface cleaners, and disinfectants
N-Hexyl glycol is be used as Primary solvent in solvent-based silk screen printing inks

Storage & Handling:
N-Hexyl glycol should be stored under nitrogen.
The storage temperature must not exceed 40 °C and moisture are excluded.
Under these conditions, a storage stability of 12 months can be expected.

SAFETY INFORMATION ABOUT N-HEXYL GLYCOL:

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

N-Hexyl glycol, also known as 2-hexyl-1-ethanol, is an alcohol compound with the chemical formula C₈H₁₈O.
N-Hexyl glycol (2-hexyl-1-ethanol) is an organic compound with a straight-chain hexyl group.
N-Hexyl glycol is classified as a primary alcohol due to the presence of the hydroxyl (-OH) group attached to a primary carbon atom.

CAS Number: 111-27-3
EC Number: 203-872-2

APPLICATIONS

N-Hexyl glycol finds extensive use as a solvent in various industries, including coatings, paints, and varnishes.
N-Hexyl glycol is commonly employed as a coupling agent to aid in the mixing and dispersing of different components in formulations.

N-Hexyl glycol is used in the production of printing inks, providing solvency and enhancing the flow properties of the ink.
N-Hexyl glycol acts as a solvent for textile dyes, aiding in the dyeing and printing processes.
N-Hexyl glycol is utilized as a solvent for adhesives, facilitating their application and bonding properties.

In the cosmetics and personal care industry, N-hexyl glycol can be found in various products such as lotions, creams, and hair care formulations.
N-Hexyl glycol functions as a solvent for active ingredients in pharmaceutical formulations, assisting in their solubility and stability.
N-Hexyl glycol is used as a component in cleaning products, providing solvency and aiding in the removal of dirt and grime.

N-Hexyl glycol serves as a coalescing agent in latex paints, enabling the particles to fuse together and form a continuous film upon drying.
N-Hexyl glycol is employed in the formulation of industrial and household cleaners, contributing to their cleaning efficacy.
N-Hexyl glycol is used as a solvent for resins and polymers in the production of various plastic and rubber products.

N-Hexyl glycol finds application as a solvent and dispersant in the formulation of pesticides and agricultural chemicals.
N-Hexyl glycol is utilized in the formulation of wood coatings and stains, providing solvency and improving the coating's durability.

N-Hexyl glycol is employed in the production of specialty chemicals, including flavors and fragrances.
N-Hexyl glycol is used as a solvent in the formulation of inks for markers and pens.

N-Hexyl glycol finds use in the formulation of industrial degreasers and cleaning solutions for metal surfaces.
N-Hexyl glycol is utilized in the formulation of automotive care products such as polishes and waxes.
N-Hexyl glycol serves as a solvent for corrosion inhibitors in metalworking fluids and rust-preventive coatings.

N-Hexyl glycol finds application in the formulation of oilfield chemicals, such as drilling fluids and well stimulation fluids.
N-Hexyl glycol is used as a solvent for the extraction of natural products and essential oils.

N-Hexyl glycol can be found in the formulation of air fresheners and household fragrance products.
N-Hexyl glycol is employed as a solvent in the production of specialty chemicals used in the electronics industry.
N-Hexyl glycol is used as a solvent and viscosity modifier in the formulation of liquid detergents and cleaning agents.

N-Hexyl glycol serves as a solvent for fragrances and fixatives in the formulation of perfumes and colognes.
N-Hexyl glycol finds application in the formulation of printing chemicals, such as fountain solutions and plate cleaners.

N-Hexyl glycol is used as a solvent in the formulation of industrial and household paints, providing improved flow and dispersion of pigments.
N-Hexyl glycol serves as a wetting agent in agricultural formulations, aiding in the spreading and absorption of pesticides and herbicides on plant surfaces.
N-Hexyl glycol finds application in the formulation of leather and textile finishes, enhancing the softness and durability of the materials.
N-Hexyl glycol is utilized as a solvent for fragrances and essential oils in the production of perfumes, colognes, and body care products.

N-Hexyl glycol acts as a dispersant in the formulation of suspension concentrates and emulsifiable concentrates in the agricultural sector.
N-Hexyl glycol is used as a solvent for resins and binders in the formulation of adhesive and sealant products.
N-Hexyl glycol finds application as a component in antifoam formulations, reducing foam formation in various industrial processes.

N-Hexyl glycol is utilized as a solvent in the formulation of industrial and institutional cleaning products, contributing to their effectiveness.
N-Hexyl glycol is used in the formulation of automotive coatings, providing improved adhesion and durability.
N-Hexyl glycol finds application in the production of specialty chemicals used in the oil and gas industry.

N-Hexyl glycol serves as a solvent for the formulation of wood preservatives, protecting the wood from decay and insect damage.
N-Hexyl glycol is used as a solvent in the formulation of water-based inks for flexographic and gravure printing.

N-Hexyl glycol finds application in the formulation of brake fluids, ensuring proper hydraulic performance in automotive braking systems.
N-Hexyl glycol is utilized as a solvent in the formulation of electroplating baths, facilitating the deposition of metal coatings on substrates.

N-Hexyl glycol is used as a component in corrosion inhibitors, protecting metal surfaces from oxidation and rust.
N-Hexyl glycol finds application in the formulation of industrial lubricants and metalworking fluids, improving their performance and stability.
N-Hexyl glycol is utilized as a solvent for cleaning and degreasing metal surfaces prior to painting or coating applications.
N-Hexyl glycol serves as a solvent and viscosity modifier in the formulation of screen printing inks.

N-Hexyl glycol finds application in the formulation of asphalt emulsions and road construction materials.
N-Hexyl glycol is used as a solvent for the formulation of cleaning agents and degreasers in the automotive and industrial sectors.

N-Hexyl glycol is utilized as a solvent for UV-curable coatings and inks, aiding in their curing process.
N-Hexyl glycol finds application in the formulation of metal cleaners and rust removers.
N-Hexyl glycol serves as a solvent and wetting agent in the formulation of crop protection products in the agriculture industry.

N-Hexyl glycol is used as a solvent for the formulation of personal care products such as hair dyes and hair styling products.
N-Hexyl glycol finds application in the formulation of industrial coolants and heat transfer fluids, ensuring efficient heat exchange.

DESCRIPTION

N-Hexyl glycol, also known as 2-hexyl-1-ethanol, is an alcohol compound with the chemical formula C₈H₁₈O.
N-Hexyl glycol (2-hexyl-1-ethanol) is an organic compound with a straight-chain hexyl group.
N-Hexyl glycol is classified as a primary alcohol due to the presence of the hydroxyl (-OH) group attached to a primary carbon atom.

N-Hexyl glycol has a molecular weight of approximately 130.23 grams per mole.
N-Hexyl glycol appears as a colorless liquid with a mild, pleasant odor.
N-Hexyl glycol is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone.

N-Hexyl glycol is primarily used as a solvent in various applications, including coatings, inks, and cleaning products.
N-Hexyl glycol can act as a coupling agent, facilitating the mixing of different components in a formulation.
N-Hexyl glycol finds use in the manufacturing of paints, varnishes, and adhesives.
As a solvent, it helps to dissolve and disperse pigments, resins, and other ingredients.

N-Hexyl glycol is also employed in the production of textile dyes and printing inks.
In the pharmaceutical industry, it can serve as a solvent for active ingredients.
Due to its low volatility, it contributes to the slow evaporation of formulations.
N-Hexyl glycol can enhance the viscosity and flow properties of certain formulations.

N-Hexyl glycol may also function as a surfactant, reducing surface tension and aiding in wetting and spreading.
N-Hexyl glycol has moderate stability and can withstand various environmental conditions.
N-Hexyl glycol is not highly flammable but should be handled with care.

N-Hexyl glycol has a boiling point of around 205-210°C (401-410°F).
N-Hexyl glycol is stable under normal storage and handling conditions.

N-Hexyl glycol is not known to undergo significant chemical reactions under typical usage scenarios.
N-Hexyl glycol is generally considered safe for use when following appropriate handling guidelines.

N-Hexyl glycol may have slight irritant properties if in direct contact with the skin or eyes.
Adequate ventilation is recommended when using products containing N-hexyl glycol.
N-Hexyl glycol is important to consult safety data sheets and follow regulatory guidelines for proper handling and disposal.

N-Hexyl glycol is not commonly used as a consumer product but rather as an industrial ingredient.
N-Hexyl glycol should be stored in tightly sealed containers away from heat, sparks, or open flames.

PROPERTIES

Chemical Formula: C₈H₁₈O
Molecular Weight: Approximately 130.23 grams per mole
Physical State: Liquid
Appearance: Colorless
Odor: Mild, pleasant odor
Solubility: Sparingly soluble in water, soluble in organic solvents like ethanol and acetone
Boiling Point: Approximately 205-210°C (401-410°F)
Melting Point: -42°C (-43.6°F)
Density: Approximately 0.832 g/cm³ at 20°C (68°F)
Vapor Pressure: Very low
Refractive Index: Approximately 1.426 at 20°C (68°F)
Flash Point: 98°C (208.4°F) (closed cup)
Autoignition Temperature: 305°C (581°F)
Viscosity: Relatively low viscosity
pH Level: Neutral (around 7)
Flammability: Not highly flammable, but it should still be handled with care and stored away from ignition sources.
Stability: Stable under normal storage and handling conditions.
Reactivity: Not known to undergo significant chemical reactions under typical usage scenarios.
Hazardous Decomposition Products: Upon strong heating, it may produce carbon monoxide, carbon dioxide, and other toxic gases.
Hazardous Polymerization: Will not occur.

FIRST AID

Inhalation:

If inhaled, remove the affected person to fresh air.
If breathing difficulties persist, seek medical attention immediately.
Provide artificial respiration if the person is not breathing, and trained personnel should administer oxygen if necessary.

Skin Contact:

Remove contaminated clothing and immediately wash the affected skin area with plenty of soap and water for at least 15 minutes.
If irritation or redness occurs, seek medical advice.
Wash contaminated clothing thoroughly before reuse.

Eye Contact:

Flush the eyes gently with lukewarm water for at least 15 minutes, while keeping the eyelids open.
Seek immediate medical attention and ensure to provide information about the substance involved.

Ingestion:

Rinse the mouth thoroughly with water without swallowing.
Do not induce vomiting unless instructed to do so by medical professionals.
Seek medical attention immediately.
If vomiting occurs spontaneously and the person is conscious, place them in a recovery position to prevent choking.

HANDLING AND STORAGE

Handling:

Ensure adequate ventilation in the working area to maintain air quality and prevent the accumulation of vapors.
Use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and protective clothing to minimize skin and eye contact.
Avoid inhalation of vapors or mists.
If necessary, use respiratory protection equipment in accordance with occupational safety guidelines.

Handle the compound in a well-controlled and enclosed system to minimize the release of vapors into the environment.
Avoid eating, drinking, or smoking while handling the substance.
Wash hands thoroughly with soap and water after handling to remove any residual traces.

Storage:

Store N-hexyl glycol in tightly sealed containers made of compatible materials, such as high-density polyethylene (HDPE) or glass, to prevent leakage or evaporation.
Keep the containers in a cool, well-ventilated area away from direct sunlight, heat sources, sparks, and open flames.
Maintain appropriate temperature and humidity conditions to ensure the stability of the compound.
Store the substance separately from oxidizing agents, strong acids, and bases to prevent potential chemical reactions.

Label the storage containers clearly with the name of the substance and any relevant hazard warnings.
Store in a dedicated area or cabinet specifically designated for flammable or hazardous substances, following local regulations and guidelines.
Implement proper inventory management and control measures to ensure the correct storage and rotation of stock.
Regularly inspect the storage area for any signs of damage, leakage, or deterioration, and address any issues promptly.

SYNONYMS

Hexyl alcohol
Caproyl alcohol
1-Hexanol
Hexan-1-ol
Hexyl hydride
n-Hexyl alcohol
n-Hexanol
Alcohol C-6
Hexanol-1
Caproic alcohol
Hexyl carbinol
Hexan-1-ol
Hexanol
Hexyl hydrate
Caproic acid alcohol
n-Hexanol
n-Hexyl carbinol
Alcool hexylique
Alcohol hexilico
1-Hydroxyhexane
1-Caproyl alcohol
Caprylic alcohol
n-Hexyl alcohol
Hexylic alcohol
C6 alcohol
1-Hydroxyhexyl alcohol
Hexane-1-ol
n-Caproyl alcohol
Alcool hexylique
Hexanol-1
1-Hexyl alcohol
Alcool caproïque
Hexylalkohol
n-Hexan-1-ol
Hexylalkohol-1
n-C6H13OH
Hexyl hydroxide
Hexylol
Caproic alcohol
n-Hexanol
1-Hexyl hydride
Hexanol-1
Caproic hydride
Hexyl alcohol
Hexylic hydrate
Hexylic hydride
n-Hexyl hydride
Caprylic hydride
Caproyl hydride
1-C6 alcohol
Caproic hydride
1-Hydroxyhexyl hydride
n-Hexyl hydride alcohol
Hexyl alcohol-1
1-Hydroxyhexane-1
Alcool n-hexyl
Hexan-1-ol
Caproic acid hydride
Hexylalkohol-1
Hexylalkohol

N-Hexyl Glycol is an oily colorless liquid with a mild sweet odor.
N-Hexyl Glycol, also known as 1,6-Hexanediol, is a chemical compound with the molecular formula C6H14O2.
N-Hexyl Glycol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).

CAS Number: 107-41-5
Molecular Formula: C6H14O2
Molecular Weight: 118.17
EINECS Number: 203-489-0

N-Hexyl Glycol is a diol organic compound with a chiral carbon atom.
N-Hexyl Glycol is a colorless liquid at room temperature and can be Diacetone alcohol is hydrogenated.
The appearance is colorless liquid with mild sweetness.

N-Hexyl Glycol floats and mixes slowly with water.
N-Hexyl Glycol belongs to the class of diols, which are organic compounds containing two hydroxyl (-OH) groups.
The "n" in N-Hexyl Glycol indicates that the carbon chain is linear.

N-Hexyl Glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-Hexyl Glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
N-Hexyl Glycol's miscibility with water, however, is limited.

N-Hexyl Glycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
Since N-Hexyl Glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2.6-di-tert-butyl-paracresol N-Hexyl Glycol is as a solvent for coatings and degreasing.
N-Hexyl Glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry.

The chemical structure of N-Hexyl Glycol consists of a hexane backbone (a six-carbon linear chain) with two hydroxyl groups (-OH) attached at each end.
N-Hexyl Glycol is a colorless liquid with a mild odor.
N-Hexyl Glycol is soluble in water and has various applications in different industries.

N-Hexyl Glycol is used in printing inks and cleaners.
N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
N-Hexyl Glycol has a low evaporation rate and it is completely miscible with water.

N-Hexyl Glycol is mainly used as a solvent or coupling agent. It is a potential substitute for glycol ethers.
N-Hexyl Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
N-Hexyl Glycol is often used in cosmetics and personal care products for its moisturizing properties.

N-Hexyl Glycol can contribute to the hydration of the skin when included in formulations such as creams and lotions.
In the flavor and fragrance industry, N-Hexyl Glycol can be utilized as a carrier for certain flavors and fragrances.
N-Hexyl Glycol is mild odor and solvency make it suitable for use in these applications.

N-Hexyl Glycol can be esterified with various acids to produce specific esters.
Esters derived from N-Hexyl Glycol may find use in different industries, including the fragrance and flavor industry.
N-Hexyl Glycol has been used historically in the production of photographic chemicals.

N-Hexyl Glycol is properties make it suitable for certain formulations in this industry.
N-Hexyl Glycol may be used in the formulation of metalworking fluids, where it can act as a lubricant and cooling agent during machining processes.
Due to its solvency, N-Hexyl Glycol can be incorporated into cleaning products, such as degreasers and industrial cleaners.

In the printing industry, N-Hexyl Glycol can be employed as a solvent and viscosity modifier in the formulation of printing inks.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
N-Hexyl Glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.

N-Hexyl Glycol is miscible with water, soluble in ethanol, and soluble in most organic solvents.
N-Hexyl Glycol is an oily colorless liquid with a mild sweet odor.
N-Hexyl Glycol floats and mixes slowly with water.

N-Hexyl Glycol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).
N-Hexyl Glycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor.
N-Hexyl Glycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.

N-Hexyl Glycol may be utilized in the formulation of hydraulic brake fluids. Its properties can contribute to the fluid's ability to transfer pressure and resist high temperatures in braking systems.
In the oil and gas industry, N-Hexyl Glycol might be used in the formulation of certain chemicals for oilfield applications, such as drilling fluids or completion fluids.
N-Hexyl Glycol can be employed in the formulation of coolants for various cooling systems, helping to maintain proper thermal conditions in industrial processes or automotive engines.

N-Hexyl Glycol may serve as a solvent in the pharmaceutical industry for certain drug formulations where its properties are beneficial.
N-Hexyl Glycol might be used as a catalyst or co-catalyst in organic synthesis reactions, facilitating specific chemical transformations.
In the field of hydraulic fracturing (fracking), N-Hexyl Glycol may find applications in the formulation of fracking fluids used to fracture rocks and extract natural gas or oil.

N-Hexyl Glycol can be incorporated into water treatment formulations for cooling towers to prevent scale formation and corrosion.
N-Hexyl Glycol's miscibility with water, however, is limited.
n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.

N-Hexyl Glycol may be explored in the development of electrolytes for fuel cells, contributing to the advancement of alternative energy technologies.
N-Hexyl Glycol can be used in the dyeing and textile industry, where it may assist in the solubilization and application of dyes.
N-Hexyl Glycol can serve as a carrier for certain catalysts in chemical reactions, contributing to the efficiency of the reaction process.

N-Hexyl Glycol, when incorporated into certain polymers, may contribute to the development of food packaging materials with specific properties, such as flexibility and durability.
N-Hexyl Glycol may be explored for potential applications in the production of materials used in photovoltaic devices, such as solar cells.
Since N-Hexyl Glycol may react with the oxygen in the air to form peroxides, BASF supplies it inhibited with 2.6-di-tert-butyl-paracresol.

N-Hexyl Glycol is as a solvent for coatings and degreasing.
N-Hexyl Glycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry.
N-Hexyl Glycol is used in printing inks and cleaners.

N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
N-Hexyl Glycol has a low evaporation rate and it is completely miscible with water.
N-Hexyl Glycol is mainly used as a solvent or coupling agent. It is a potential substitute for glycol ethers.

N-Hexyl Glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
N-Hexyl Glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.

Melting point: -40 °C (lit.)
Boiling point: 197 °C (lit.)
Density: 0.925 g/mL at 25 °C (lit.)
vapor density: 4.1 (vs air)
vapor pressure: 0.02 mm Hg ( 20 °C)
refractive index: n20/D 1.427(lit.)
Flash point: 201 °F
storage temp.: Store below +30°C.
solubility: H2O: 1 M at 20 °C, clear, colorless
form: Slightly Viscous Liquid
pka: 15.10±0.29(Predicted)
color: Clear
PH: 6-8 (25℃, 1M in H2O)
Odor: Ammonia-like.
explosive limit: 1-9.9%(V)
Water Solubility: soluble
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck: 14,4710
BRN: 1098298
Exposure limits ACGIH: TWA 25 ppm; STEL 50 ppm(10 mg/m3)
NIOSH: Ceiling 25 ppm(125 mg/m3)
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong reducing agents.
InChIKey: SVTBMSDMJJWYQN-UHFFFAOYSA-N
LogP: 0 at 20℃

Due to its ability to lower the freezing point of water, N-Hexyl Glycol may be used in the formulation of deicing fluids, particularly in applications where prevention of ice formation is crucial.
N-Hexyl Glycol can be employed as an additive in concrete formulations.
N-Hexyl Glycol may contribute to improved workability, setting time, or other properties of concrete.

In the automotive industry, N-Hexyl Glycol might be used as a component in fuel system additives, contributing to the stability and performance of the fuel.
N-Hexyl Glycol may find use in formulations of biocides or preservatives, helping to prevent the growth of microorganisms in various products, such as paints or personal care items.
N-Hexyl Glycol might be included in certain formulations of insect repellents, contributing to the overall effectiveness of the product.

In some extraction processes, N-Hexyl Glycol may be used as a solvent for the extraction of certain compounds from natural sources.
N-Hexyl Glycol is used as penetrant, emulsifier and antifreeze.
N-Hexyl Glycol is an oily colorless liquid with a mild sweet odor.

N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.
N-Hexyl Glycol is used as a reagent in the synthesis of functionalized boronic esters.
N-Hexyl Glycol is used in laboratory studies as a precipitant and cryoprotectant in protein crystallography.

N-Hexyl Glycol may find applications in heat transfer fluids, helping to transfer heat efficiently in various industrial processes.
N-Hexyl Glycol may be used in analytical chemistry as a solvent or as a component in certain analytical methods.
N-Hexyl Glycol is a member of the glycol ether family, which includes various compounds used in different industries for their solvency, stability, and other properties.

N-Hexyl Glycol also used in the preparation of vinylboronates.
N-Hexyl Glycol is mainly used as a coupling agent and an additive to hydraulic fluids, inks and cement.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.

N-Hexyl Glycol is also employed as a blood volume expander.
N-Hexyl Glycol can be used in formulations for the silk screen process to prevent premature setting of the ink.
N-Hexyl Glycol may be used in the tire manufacturing industry as a component in adhesives for tire cord, contributing to the bonding properties of the adhesive.

N-Hexyl Glycol may be employed as an antioxidant in fuel formulations to help prevent degradation and improve the stability of the fuel.
N-Hexyl Glycol might be considered as a component in wood preservatives, helping to protect wood from decay and insect damage.

In coatings and paint formulations, N-Hexyl Glycol could be used as an additive to modify certain properties of the coating, such as drying time or film formation.
N-Hexyl Glycol can be part of surfactant formulations where its properties contribute to the stability of emulsions or foams.

Preparation:
Using 2000 L of diacetone alcohol as a raw material to synthesize isohexanediol by hydrogenation reduction, the specific process steps are:Step 1: Start the vacuum pump to vacuum the raw material metering tank.
When the vacuum is greater than -0.06Mpa, close the exhaust valve, open the feed valve, mix 2000 L of diacetone alcohol raw material and 200ppm sodium bicarbonate and pump it in Raw material metering tank.
Step 2: Open the vacuum valve on the reduction pot and pump the reduction pot to a vacuum of -0.1Mpa, then open the feed valve on the reduction pot, and add 2000 L of diacetone alcohol raw material and 200ppm sodium bicarbonate from the metering tank To the reduction pot, start the mixer to stir at the same time, add 95Kg of Raney nickel catalyst.

Step 3: Close the vacuum valve, open the nitrogen inlet valve, and inject nitrogen into the reduction pot.
After the pressure in the pot is increased to 0.6Mpa within 3 to 5 minutes, close the hydrogen inlet valve, open the vent valve, and reduce the pressure in the pot.
Reduce to normal pressure, repeat the above steps, re-inject nitrogen for replacement, and repeat this five times.

Step 4: When the nitrogen replacement in the third step is completed, close the vent valve, open the hydrogen inlet valve, and inject hydrogen into the reduction pot within 10-15 minutes.
When the pressure in the pot reaches 0.6Mpa, close the hydrogen inlet valve.
Open the vent valve, after the pressure in the pot drops to normal pressure, close the vent valve, repeat the above steps, re-inject hydrogen for replacement, and repeat this five times.

Step 5: After the hydrogen replacement, close the vent valve, open the hydrogen gas inlet valve, and inject hydrogen into the reduction pot.
Use hydrogen to make the pressure in the pot reach 1.9Mpa within 15 to 30 minutes, then close the hydrogen gas inlet valve and open it.
Jacketed steam valve, raise the temperature in the pot to 150°C, and adjust the stirring speed to 310r/min.

At this time, open the hydrogen gas inlet valve and control the temperature in the pot at 150°C.
On the basis of the stable temperature in the pot, Keep the hydrogen vapor pressure at 1.9Mpa for 4 hours, then close the hydrogen gas inlet valve and accurately record the current pressure in the boiler.
After 30 minutes, take a sample for gas chromatographic testing.

If the raw material content is less than 1% in the test result, it is qualified.
At this time, Close the jacketed steam valve and open the jacketed cooling water to reduce the temperature in the pot to normal temperature.
Then, open the vent valve to reduce the pressure in the pot to normal pressure.

Step 6: Stop the mixer and let it stand for 50 minutes, close the vent valve, open the nitrogen inlet valve, use nitrogen to increase the pressure in the pot to 0.6Mpa, close the nitrogen valve, open the empty valve, and slowly reduce the pressure in the pot to normal pressure , And then repeat this step 5 times.
Step 7: Open the nitrogen valve and the feed valve of the distillation pot at the same time.
Use 0.8Mpa nitrogen to send the qualified materials to the filter for filtration.

The filtered materials are pumped into the crude isohexanediol storage tank, and then pressed to the distillation Distillation is carried out in the kettle, and the filtered catalyst is recycled; the finished product from the rectification is isohexanediol.
After the raw material of 2000 L diacetone alcohol is hydrogenated and reduced to synthesize, 1865Kg of isohexanediol product is obtained with a purity of 99.5%.

The mass yield is 99%. After cooling, it is placed in the isohexanediol product storage tank.
The remaining by-products are mainly 29kg of 98% acetone, which can be sold as industrial acetone.

Uses:
N-Hexyl Glycol is a fine chemical product with a wide range of uses, which can be used in pesticides, biochemical engineering, photosensitive materials, synthetic fragrances and other fields.
N-Hexyl Glycol is a highly soluble high-grade organic solvent.
N-Hexyl Glycol can be used as an additive in the production of metal surface treatment agents for rust and oil removal.

N-Hexyl Glycol can also be used as a textile auxiliaries, as well as coatings and latex paints.
N-Hexyl Glycol can also be used in cosmetics, as a pesticide stabilizer, but also as a daily chemical moisturizer, flavor and fragrance raw materials, hydraulic oil, high-temperature lubricating oil, brake oil, dry cleaning agent, printing ink, pigment dispersant, wood preservative etc.

N-Hexyl Glycol is used in skincare and hair care formulations for its moisturizing properties.
Included in creams, lotions, and shampoos.
Serves as a solvent in the production of paints and coatings.

Contributes to the viscosity and consistency of paint formulations.
Can contribute to the adhesive properties and work as a carrier for other components.
N-Hexyl Glycol is used in the synthesis of certain polymers.

Employed as a solvent in the formulation of printing inks.
Aids in the dispersion of pigments and other ink components.
Included as a component in fuel additives to improve stability and performance.

N-Hexyl Glycol is used in the dyeing and textile industry to solubilize and apply dyes.
Included in cleaning products such as degreasers and industrial cleaners.
N-Hexyl Glycol is used in the formulation of deicing fluids due to its ability to lower the freezing point of water.

Included as an additive in concrete formulations to improve workability and other properties.
N-Hexyl Glycol is used in formulations of biocides or preservatives to prevent the growth of microorganisms.
N-Hexyl Glycol is used in the formulation of hydraulic brake fluids and other automotive fluids.

Included in heat transfer fluids to aid in the transfer of heat in various industrial processes.
When incorporated into certain polymers, it can contribute to the development of food packaging materials.
Explored for potential applications in the development of electrolytes for fuel cells.

N-Hexyl Glycol is used as an additive in concrete formulations to improve workability and setting time.
Utilized in the oil and gas industry for the formulation of certain chemicals for oilfield applications.
N-Hexyl Glycol explored for potential applications in the production of materials used in photovoltaic devices.

N-Hexyl Glycol is used as a reagent in the synthesis of functionalized boronic esters.
N-Hexyl Glycol is used in laboratory studies as a precipitant and cryoprotectant in protein crystallography.
Also used in the preparation of vinylboronates.

N-Hexyl Glycol is mainly used as a coupling agent and an additive to hydraulic fluids, inks and cement.
Further, N-Hexyl Glycol is used as a solvent for cleaning and colorant products.
N-Hexyl Glycol is a potential substitute for glycol ethers.

N-Hexyl Glycol is an effective shrinkage reduction admixture or SRA for concrete and mortar.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
Hexylene glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.It is used to control the flow properties of industrial products such as paints, coatings, cleansers, solvents, and hydraulic fluids.

N-Hexyl Glycol acts as a thickening agent in cosmetic products.
N-Hexyl Glycol is also employed as a blood volume expander.
N-Hexyl Glycol is used to control the flow properties of industrial products such as paints, coatings, cleansers, solvents, and hydraulic fluids.

N-Hexyl Glycol acts as a thickening agent in cosmetic products.
N-Hexyl Glycol serves as a coupling agent and an additive to hydraulic fluids, inks and cement.
N-Hexyl Glycol is also employed as a blood volume expander.

Further, N-Hexyl Glycol is used as a solvent for cleaning and colorant products.
In addition to this, N-Hexyl Glycol is used in laboratory studies as a precipitant and cryoprotectant in protein crystallography.
N-Hexyl Glycol can also be used as a textile auxiliaries, as well as coatings and latex paints.

N-Hexyl Glycol can be used in the polymer industry as a component in the synthesis of certain polymers.
N-Hexyl Glycol may contribute to the properties of the resulting polymer, such as flexibility and durability.
Due to its solvency properties, N-Hexyl Glycol is utilized in the formulation of adhesives and sealants.

N-Hexyl Glycol can contribute to the adhesive properties and work as a carrier for other components.
In the production of inks, N-Hexyl Glycol can function as a solvent, aiding in the dispersion of pigments and other ink components.
N-Hexyl Glycol may be used in antifreeze formulations. Its ability to lower the freezing point of water makes it suitable for applications where protection against freezing is required.

In hydraulic fluids, N-Hexyl Glycol can be included to provide lubrication and to help maintain the fluidity of the hydraulic system.
N-Hexyl Glycol is commonly used in the paint and coatings industry as a solvent. Its solvency properties contribute to the formulation of coatings, providing proper viscosity and consistency.
N-Hexyl Glycol can serve as a building block or starting material in the synthesis of various chemicals in the laboratory or industrial processes.

In certain applications, N-Hexyl Glycol may be used as a component in fuel additives to improve fuel performance or characteristics.
N-Hexyl Glycol may find use in research and development activities, particularly in laboratories exploring new formulations, materials, or chemical processes.
In some cases, N-Hexyl Glycol may be employed in the production of surfactants, which are compounds that can lower the surface tension between two phases (e.g., between a liquid and a solid).

N-Hexyl Glycol can also be used in cosmetics, as a pesticide stabilizer, but also as a daily chemical moisturizer, flavor and fragrance raw materials, hydraulic oil, high-temperature lubricating oil, brake oil, dry cleaning agent, printing ink, pigment dispersant, wood preservative etc.
N-Hexyl Glycol is used in printing inks and cleaners.
N-Hexyl Glycol is an oxygenated solvent derived from acetone which has two alcohol functions.

N-Hexyl Glycol is used as a solvent in various applications, including coatings, paints, and inks.
N-Hexyl Glycol is employed in the formulation of cosmetics and personal care products, such as skin creams and lotions.
N-Hexyl Glycol can serve as an intermediate in the synthesis of other chemicals.

N-Hexyl Glycol may be used as a plasticizer in the production of plastics.
N-Hexyl Glycol is hygroscopic, meaning it has a tendency to absorb moisture from the air.
N-Hexyl Glycol is considered to be biodegradable, which means it can be broken down by natural processes over time.

N-Hexyl Glycol is mainly used as a solvent or coupling agent.
N-Hexyl Glycol can also be used as a building block in chemical synthesis.
N-Hexyl Glycol is used as a carrier for certain catalysts in chemical reactions, aiding in the efficiency of the reaction process.

Included as a component in fuel system additives, contributing to the stability and performance of the fuel.
Employed in analytical chemistry as a solvent or as a component in certain analytical methods.
N-Hexyl Glycol is part of the glycol ether family, which includes various compounds used in different industries for their solvency, stability, and other properties.

N-Hexyl Glycol is used in the formulation of deicing fluids to prevent ice formation on surfaces.
Included as a component in wood preservatives, helping protect wood from decay and insect damage.
Incorporated into water treatment formulations for cooling towers to prevent scale formation and corrosion.

Historically used in the production of photographic chemicals for its specific properties.
N-Hexyl Glycol is utilized in the formulation of metalworking fluids, providing lubrication and cooling during machining processes.
N-Hexyl Glycol is used as a carrier for certain flavors and fragrances due to its mild odor and solvency.

Included in certain food products for its solubility and other functional properties.
N-Hexyl Glycol is used in the tire manufacturing industry as a component in adhesives for tire cord, contributing to bonding properties.
Employed in the formulation of coolants for various cooling systems, helping to maintain proper thermal conditions.

Part of surfactant formulations where its properties contribute to the stability of emulsions or foams.
May find applications in hydraulic fracturing fluids used in oil and gas extraction processes.
Included as an antioxidant in fuel formulations to prevent degradation and improve stability.

Safety Profile:
N-Hexyl Glycol may cause irritation to the skin and eyes upon contact.
N-Hexyl Glycol's important to use appropriate personal protective equipment, such as gloves and safety goggles, when handling this substance.

Inhalation of vapors or mists of N-Hexyl Glycol may cause respiratory irritation.
Ensure adequate ventilation in areas where N-Hexyl Glycol is used and consider using respiratory protection if needed.
Ingesting N-Hexyl Glycol can be harmful.

N-Hexyl Glycol is not intended for consumption, and ingestion may lead to adverse health effects.
N-Hexyl Glycol is hygroscopic, meaning it can absorb moisture from the air.
This property can lead to changes in the physical characteristics of the substance and may affect its handling properties.

While N-Hexyl Glycol itself is not highly flammable, it may still pose a fire hazard under certain conditions.
Take appropriate precautions to prevent ignition sources in areas where it is handled.

Synonyms:
Hexylene glycol
2-METHYL-2,4-PENTANEDIOL
107-41-5
2-Methylpentane-2,4-diol
Diolane
Pinakon
2,4-Pentanediol, 2-methyl-
2,4-Dihydroxy-2-methylpentane
Isol
4-Methyl-2,4-pentanediol
1,1,3-Trimethyltrimethylenediol
Caswell No. 574
2-Methyl pentane-2,4-diol
2-Methyl-2,4-pentandiol
hexyleneglycol
HSDB 1126
UNII-KEH0A3F75J
(+-)-2-Methyl-2,4-pentanediol
NSC 8098
NSC-8098
EINECS 203-489-0
KEH0A3F75J
alpha,alpha,alpha'-Trimethyltrimethylene glycol
EPA Pesticide Chemical Code 068601
BRN 1098298
1,3-dimethyl-3-hydroxybutanol
CCRIS 9439
DTXSID5021885
CHEBI:62995
AI3-00919
Hexylene glycol [NF]
1,3,3-trimethyl-1,3-propanediol
TRACID RUBINE 5BL
DTXCID101885
EC 203-489-0
1,1,3-trimethyl-1,3-propanediol
4-01-00-02565 (Beilstein Handbook Reference)
MFCD00004547
Hexylene glycol (NF)
HEXYLENE GLYCOL (II)
HEXYLENE GLYCOL [II]
7-MethylAtracuriumDimesylate(MixtureofDiastereomers)
MPD
HEXYLENE GLYCOL (MART.)
HEXYLENE GLYCOL [MART.]
HEXYLENE GLYCOL (USP-RS)
HEXYLENE GLYCOL [USP-RS]
CAS-107-41-5
2-Methylpentan-2,4-diol
2-Methyl-pentane-2,4-diol
64229-01-2
Hexylene glycol, 99%
R-(-)-2-METHYL-2,4-PENTANEDIOL
2methyl-2,4-pentanediol
2-methyl-2-4-pentanediol
Hexylene glycol, >=99%
Hexylene glycol, 99.5%
SCHEMBL19379
HEXYLENE GLYCOL [MI]
1,3-Trimethyltrimethylenediol
HEXYLENE GLYCOL [HSDB]
HEXYLENE GLYCOL [INCI]
CHEMBL2104293
NSC8098
(?)-2-Methyl-2,4-pentanediol
SVTBMSDMJJWYQN-UHFFFAOYSA-N
HMS3264E19
HY-B0903
Hexylene glycol, analytical standard
Tox21_201975
Tox21_302818
(+/-)-2-Methyl-2,4-pentanediol
s3588
AKOS015901459
CCG-213719
WLN: QY1 & 1XQ1 & 1
NCGC00249143-01
NCGC00256494-01
NCGC00259524-01
(+/-)-2,4-Dihydroxy-2-methyl pentane
AC-13749
AS-58339
Hexylene glycol, BioXtra, >=99% (GC)
(+/-)-2-Methyl-2,4-pentanediol, MPD
FT-0605050
FT-0605756
FT-0613069
Hexylene glycol, puriss., >=99.0% (GC)
M0384
(S)-(-)-2-METHYL-2,4-PENTANEDIOL
.alpha.,.alpha.'-Trimethyltrimethylene glycol
Hexylene glycol, BioUltra, >=99.0% (GC)
D04439
EN300-170052
AB01563179_01
J-640306
J-660006
Q2792203
W-108748
Z1255485267
Hexylene glycol, United States Pharmacopeia (USP) Reference Standard

N-Hexyl glycol, also known as N-hexyl glycol (Hexyl cellosolve solvent), is a chemical compound that falls into the class of glycol ethers.
Its chemical structure consists of a hexyl group (a six-carbon alkyl chain) attached to a glycol ether functional group.
The systematic name for N-hexyl glycol (Hexyl cellosolve solvent) is 2-(2-Hexyloxyethoxy)ethanol.

CAS Number: 112-25-4
EC Number: 203-951-1

Hexyl Cellosolve Solvent, 2-(2-Hexyloxyethoxy)ethanol, N-Hexyl glycol, Hexyl cellosolve, Hexyl ethylene glycol, 2-Hexyloxyethanol, 2-(2-Hexyloxyethoxy)ethanol, Hexyl glycol ether, Hexyl oxitol, Hexyl 2-(2-hexyloxyethoxy)ethyl ether, Hexyl 2-(2-hexyloxyethoxy)ethanol, Hexyl 2-(2-hexyloxyethoxy)ethyl alcohol, Hexyl 2-(2-hexyloxyethoxy)ethoxyethanol, 2-Hexyloxyethyl ether, 2-Hexyl oxyethanol, Hexyl oxitol solvent, Hexyl 2-(2-hexyloxyethoxy)ethyl, Hexyl 2-(2-hexyloxyethoxy)ethyl ester

APPLICATIONS

N-hexyl glycol (Hexyl cellosolve solvent) is extensively used in the formulation of paints and coatings, where it contributes to pigment dispersion and film formation.
In the printing ink industry, N-hexyl glycol (Hexyl cellosolve solvent) is a valuable component, enhancing stability and consistency in ink formulations.
Its solvency properties make it a preferred choice in the creation of cleaning solutions for industrial and household applications.
N-hexyl glycol (Hexyl cellosolve solvent) serves as a degreasing agent, effectively removing oily substances and contaminants from surfaces.

N-hexyl glycol (Hexyl cellosolve solvent) finds application in the electronics industry for formulating cleaning solutions used on delicate electronic components and circuit boards.
In the adhesive and sealant industry, it enhances the performance of formulations, acting as a plasticizer and modifier.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in varnishes, contributing to their application properties and durability.
N-hexyl glycol (Hexyl cellosolve solvent) acts as a coalescing agent in paint formulations, ensuring uniform film formation and improved coating characteristics.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the production of rust removers, aiding in the removal of rust and corrosion from metal surfaces.
In hydraulic fluids, Hexyl Cellosolve Solvent contributes to lubricating properties, enhancing the efficiency of hydraulic systems.
Metalworking fluids benefit from its inclusion, providing cooling and lubrication during machining processes.

N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the formulation of conveyor belt lubricants, ensuring smooth operation and longevity of belts.
Its compatibility with elastomers makes it valuable in the formulation of rubber products with specific performance requirements.

Automotive refinishing applications benefit from its use in paint formulations, contributing to high-quality and durable coatings.
N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into specialty cleaning products used for the maintenance and cleaning of machinery and equipment.
Its mild odor makes it suitable for formulations where minimal or no fragrance is desired, such as certain cleaning products.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of environmentally friendly industrial products, aligning with sustainable practices.

The textile industry utilizes N-hexyl glycol (Hexyl cellosolve solvent) in dyeing processes, aiding in the dispersion and fixation of dyes on fabrics.
N-hexyl glycol (Hexyl cellosolve solvent) plays a role in the creation of transparent coatings, providing visual clarity and colorless properties.

In the production of lubricity improvers, it enhances the lubricating properties of various formulations.
Certain specialty applications benefit from derivatives of Hexyl Cellosolve Solvent, tailored to achieve specific industrial needs.
N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of water-based and solvent-based products, showcasing its versatility.

Its application in the creation of ink removers highlights its efficiency in cleaning solutions for printing equipment.
N-hexyl glycol (Hexyl cellosolve solvent) is used in the formulation of household cleaning products, contributing to their effectiveness in removing stains and dirt.
N-hexyl glycol (Hexyl cellosolve solvent) serves as a valuable component in the creation of high-performance industrial products across diverse sectors.

N-hexyl glycol (Hexyl cellosolve solvent) is a key ingredient in the formulation of wood finishes and stains, providing effective penetration and enhancing the color of wood surfaces.
Its use in certain pesticide formulations as a co-solvent improves the dispersion and effectiveness of active ingredients.

N-hexyl glycol (Hexyl cellosolve solvent)'s compatibility with resins makes it essential in the production of adhesive formulations, ensuring strong and durable bonds.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the creation of specialty industrial and institutional cleaners, offering effective removal of contaminants.

In the leather industry, it is utilized in the formulation of leather finishing products, contributing to texture and appearance.
The versatility of this glycol ether extends to the formulation of certain personal care products, such as hand sanitizers and skin creams.
N-hexyl glycol (Hexyl cellosolve solvent) is used in the creation of ink formulations for various writing instruments, ensuring smooth and consistent flow.
Its inclusion in certain hydraulic fluids enhances their lubricity, promoting efficient operation in hydraulic systems.

N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of metalworking fluids, providing cooling and lubrication during machining and cutting processes.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of conveyor belt lubricants, ensuring the smooth operation of belts in industrial settings.
N-hexyl glycol (Hexyl cellosolve solvent) plays a crucial role in the formulation of rust inhibitors, protecting metal surfaces from corrosion in various applications.
Hexyl Cellosolve Solvent is used in the creation of degassing agents, enhancing their efficiency in removing air bubbles from formulations.

In the creation of inkjet printer inks, its solvency properties aid in the dispersion of color pigments for high-quality printing.
N-hexyl glycol (Hexyl cellosolve solvent) is applied in the production of defoamers, helping to control foam formation in various industrial processes.
N-hexyl glycol (Hexyl cellosolve solvent) finds utility in the formulation of cooling tower water treatment chemicals, preventing scale and corrosion.
Its use in the creation of brake fluids contributes to the fluid's stability and performance in automotive braking systems.

N-hexyl glycol (Hexyl cellosolve solvent) is employed in the formulation of certain wood preservatives, protecting wood from decay and insect damage.
N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the production of certain sealants, ensuring proper adhesion and sealing properties.
In the creation of cutting fluids used in metal machining, it aids in cooling and lubricating the cutting tool and workpiece.

N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain fuel additives, enhancing fuel stability and combustion efficiency.
N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of certain paint strippers, facilitating the removal of old paint and coatings.
Its inclusion in certain household and industrial detergents enhances their cleaning efficiency on various surfaces.
In the creation of polymer dispersions, it aids in the stabilization and dispersion of polymer particles in water-based formulations.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the formulation of certain floor polishes, providing gloss and protection to flooring surfaces.
N-hexyl glycol (Hexyl cellosolve solvent) is applied in the production of certain drilling fluids, contributing to the lubrication and stability of the drilling process.

N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the formulation of specialty inks for flexographic and gravure printing, ensuring precise and consistent printing on various substrates.
Its compatibility with epoxy resins makes it valuable in the production of epoxy-based adhesives, providing strong and durable bonds.

In the electronics industry, it is incorporated into the formulation of solder fluxes, aiding in the soldering process by reducing oxidation.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the creation of paint removers, facilitating the stripping of old paint and coatings from surfaces.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the production of certain agricultural formulations, contributing to the effectiveness of herbicides and insecticides.
In the cosmetics industry, it is found in the formulation of certain makeup and skincare products, acting as a solubilizer and stabilizer.

N-hexyl glycol (Hexyl cellosolve solvent) is applied in the creation of fuel system cleaners, helping to remove deposits and improve engine performance.
Its use in the formulation of cutting-edge nanomaterials and nanoparticles showcases its versatility in advanced materials science.

N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain pharmaceutical formulations, aiding in the solubility of active ingredients for medicinal applications.
N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of mold release agents, ensuring easy release of molded products from molds.

In the production of specialty coatings for optical lenses, it aids in achieving anti-reflective and scratch-resistant properties.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the creation of ink formulations for digital printing, delivering high-quality prints with vibrant colors and clarity.
N-hexyl glycol (Hexyl cellosolve solvent) is used in the production of certain insect repellents, enhancing the dispersion of active repellent ingredients.
In the creation of automotive windshield washer fluids, it contributes to the formulation's ability to effectively clean and remove debris.

N-hexyl glycol (Hexyl cellosolve solvent) is applied in the production of certain photographic chemicals, aiding in the development and processing of photographs.
N-hexyl glycol (Hexyl cellosolve solvent) is utilized in the creation of air fresheners, contributing to the dispersion of fragrances in various formulations.
Its use in the formulation of specialty coatings for electronic displays helps achieve anti-glare and anti-scratch properties.
N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain leather conditioners, contributing to softness and protection of leather surfaces.

N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of certain anti-fogging agents, enhancing visibility on surfaces prone to fogging.
In the formulation of certain resin-based dental materials, it aids in achieving proper consistency and handling properties.
N-hexyl glycol (Hexyl cellosolve solvent) is applied in the creation of specialty lubricants, providing effective lubrication in precision machinery and equipment.

N-hexyl glycol (Hexyl cellosolve solvent) contributes to the formulation of certain heat transfer fluids, enhancing the efficiency of heat exchange systems.
In the creation of industrial floor coatings, it helps achieve durable and chemically resistant finishes for high-traffic areas.

N-hexyl glycol (Hexyl cellosolve solvent) is used in the formulation of certain wood coatings, contributing to protection against UV radiation and weathering.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the production of certain sealant primers, ensuring proper adhesion to various substrates.

DESCRIPTION

N-Hexyl glycol, also known as N-hexyl glycol (Hexyl cellosolve solvent), is a chemical compound that falls into the class of glycol ethers.
Its chemical structure consists of a hexyl group (a six-carbon alkyl chain) attached to a glycol ether functional group.
The systematic name for N-hexyl glycol (Hexyl cellosolve solvent) is 2-(2-Hexyloxyethoxy)ethanol.

N-Hexyl glycol, commonly known as Hexyl Cellosolve Solvent, is a clear and colorless liquid with a mild, characteristic odor.
N-hexyl glycol (Hexyl cellosolve solvent) is valued for its versatile solvency, making it a preferred choice in various industrial formulations.
N-hexyl glycol (Hexyl cellosolve solvent) is an organic compound featuring a hexyl group attached to a glycol ether functional group.

With its clear appearance, it is often utilized in applications where visual clarity is essential, such as in transparent coatings.
As a solvent, N-hexyl glycol (Hexyl cellosolve solvent) exhibits excellent dissolving properties, allowing it to dissolve a wide range of substances effectively.
N-hexyl glycol (Hexyl cellosolve solvent) is employed in the formulation of paints, coatings, and inks, where it aids in pigment dispersion and film formation.

Its molecular structure, with a hexyl chain, contributes to its balance between hydrophobic and hydrophilic characteristics.
N-hexyl glycol (Hexyl cellosolve solvent)'s solvency extends to cleaning products, making it an efficient degreasing agent with industrial and household applications.
N-hexyl glycol (Hexyl cellosolve solvent) is known for its compatibility with various materials, enhancing its versatility in different formulations.

In certain specialty applications, derivatives of this glycol ether are used to achieve specific properties tailored to unique industrial needs.
N-hexyl glycol (Hexyl cellosolve solvent) serves as a plasticizer and modifier in certain formulations, contributing to flexibility and improved characteristics.

Due to its chemical properties, Hexyl Cellosolve Solvent acts as a coalescing agent in paint formulations, ensuring a uniform film.
In the electronics industry, it is employed in the creation of cleaning solutions for delicate electronic components and circuit boards.
N-hexyl glycol (Hexyl cellosolve solvent) finds application in the production of adhesives, sealants, and varnishes, enhancing their performance.

Its mild odor is advantageous in formulations where minimal or no fragrance is desired, such as certain cleaning products.
N-hexyl glycol (Hexyl cellosolve solvent)'s effectiveness as a degreasing agent makes it suitable for applications where the removal of oily substances is crucial.
Hexyl Cellosolve Solvent exhibits a balanced evaporation rate, contributing to its utility in various coating and cleaning formulations.

As a hexyl ether, N-hexyl glycol (Hexyl cellosolve solvent) demonstrates a blend of properties that make it versatile in both water-based and solvent-based formulations.
Its use in the formulation of rust removers highlights its effectiveness in removing rust and corrosion from metal surfaces.
In the textile industry, Hexyl Cellosolve Solvent is utilized in dyeing processes, aiding in the dispersion and fixation of dyes on fabrics.

N-hexyl glycol (Hexyl cellosolve solvent) is incorporated into certain hydraulic fluids and metalworking fluids, contributing to their lubricating properties.
Hexyl Cellosolve Solvent plays a role in automotive refinishing applications, contributing to the formulation of high-quality coatings.

Its compatibility with elastomers makes it valuable in the formulation of rubber products with specific performance requirements.
N-hexyl glycol (Hexyl cellosolve solvent) continues to be a key ingredient in the development of environmentally friendly and high-performance industrial products.
N-hexyl glycol (Hexyl cellosolve solvent)'s solvency properties make it indispensable in the formulation of inks, coatings, and cleaning solutions across diverse industries.

PROPERTIES

Boiling Point (°C @760mmHg): 208
Chemical Name: Ethylene glycol mono hexyl ether
Density (25°C) at lb/gal (g/cc): 7.37 (0.883)
Evaporation Rate (n-butyl acetate=1.0): 0.0082
Flash Point, Closed Cup: 99 °C
Freezing Point °F(°C): -58 (-50)
Hansen Solubility Parameter, dD (joules/cm3)1/2: 16
Hansen Solubility Parameter, dH (joules/cm3)1/2: 10.9
Hansen Solubility Parameter, dP (joules/cm3)1/2: 6.9
Molecular Weight: 146.2 g/mol
Solubility in Water (25°C): 0.88 wt%
Solubility Water in (25°C): 17.7 wt%
Specific Gravity (25°C): 0.866
Surface Tension (1% actives, 25 °C): 27.7 dynes/cm
Vapor Pressure (mmHg @ 20°C): 0.038
Viscosity (25°C): 4.5 cP

FIRST AID

Inhalation:

If inhaled, move the person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
Administer artificial respiration if the person is not breathing.

Skin Contact:

Remove contaminated clothing and footwear.
Wash the affected area thoroughly with soap and water.
If irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:

Flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:

Do not induce vomiting unless directed to do so by medical personnel.
Rinse mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:

Treat symptomatically.
No specific antidote.
Provide supportive care.

General Advice:

Consult a physician if necessary.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Keep the affected person warm and at rest.

HANDLING AND STORAGE

Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of vapors.
Do not eat, drink, or smoke while handling the substance.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent evaporation and contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating aerosols or mists.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where vapors may be present.

Storage:

Temperature:
Store at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.

N-HEXYLGLYCOL = HEXYL GLYCOL = ETHYLENE GLYCOL MONOHEXYL ETHER = 2-(HEXYLOXY)ETHANOL

CAS number: 112-25-4
EC number: 203-951-1
MDL Number: MFCD00045997
Molecular formula: C8H18O2 / C6H13OCH2CH2OH

n-Hexylglycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.
Two solvents, n-Hexylglycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
n-Hexylglycol's vapour is heavier than air.

n-Hexylglycol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons.
n-Hexylglycol is a glycol ether that has a chemical formula of C8H18O2.
n-Hexylglycol is a clear, mobile, neutral, slightly hygroscopic liquid with a mild odor
n-Hexylglycol (Cas No.: 112-25-4) is a high boiling pint, slow evaporating rate solvent with excellent solvency characteristics.

Since n-Hexylglycol may react with the oxygen in the air to form peroxides.
n-Hexylglycol is a colorless liquid with a slight ether odor and bitter taste.
n-Hexylglycol enters into the typical reactions of alcohols, e. g. esterification, etherification, oxidation and the formation of alcoholates.
n-Hexylglycol's miscibility with water, however, is limited.

USES and APPLICATIONS of N-HEXYLGLYCOL:
n-Hexylglycol is used high-boiling solvent.
n-Hexylglycol is used as a chemical intermediate for hexyloxyethyl phosphate and neopentanoate.
n-Hexylglycol is used as a coalescing agent in latex paints and cleaners.
n-Hexylglycol can be used as coalescent for water-borne.

n-Hexylglycol is used as special solvent for coating and ink.
n-Hexylglycol can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
n-Hexylglycol can be used as primary solvent in solvent-based silk screen printing inks.

n-Hexylglycol can be used as primary solvent in solvent-based silk screen printing inks.
n-Hexylglycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
n-Hexylglycol is used for Biological Purpose, For Microscopic Purpose, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Electrophoresis Use.

n-Hexylglycol is used as high-boiling solvent, Solvents (which become part of product formulation or mixture), and Cleaning and furnishing care products.
n-Hexylglycol is mainly used as a solvent, flow promoter and coalescent aid in the coatings industry and in printing inks and cleaners.
n-Hexylglycol is used as solvents in speciality printing inks and coalescing aids in surface coatings, coupling agent, rust remover, adhesives and surface cleaners.

n-Hexylglycol also serves as an intermediate for neopentanoate and hexyloxyethyl phosphate.
n-Hexylglycol improves the flow of many baking finish systems.
Added in small proportions to formulations for electrodeposition paints, n-Hexylglycol greatly improves film formation and levelling.
n-Hexylglycol can be used as coalescent for water-borne.

n-Hexylglycol can be used as coupling agent and solvent in household and industrial clearners, rust removers, hard surface cleaners and disinfectants.
n-Hexylglycol can be used as a solvent for paints, paints, resins, dyes, oils and lubricating oils, as well as coupling and dispersing agents.
Other uses of n-Hexylglycol are: Sealants, Adhesives, Coating products, Finger Paints, Fillers, Anti-freeze products, Plasters, Putties,

n-Hexylglycol is used Lubricants, Modelling Clay, Greases, Automotive care products, Machine wash liquids/detergents, Air fresheners, Fragrances, and Other outdoor use.
Usage of n-Hexylglycol: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
By virtue of its good solvent power, the main applications of n-Hexylglycol are as a solvent, flow promoter and coalescent aid.
n-Hexylglycol can be used as solvent in specialty printing inks.

n-Hexylglycol is also eminently suitable as a mild, low-odour co-solvent in low-aromatic mineral spirit blends for dissolving polymer binders such as Acronal 260 F.
n-Hexylglycol can also be used in printing inks and cleaners.
n-Hexylglycol series are mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.

n-Hexylglycol has excellent oil solubility, making it effective in household and industrial cleaning applications.
n-Hexylglycol is used as a coalescing agent for water-based latex-based coatings and plays an important role in specialty printing inks, including screen printing processes, where its limited water solubility and slow evaporation rate prevent premature ink settling .
n-Hexylglycol has excellent oil solubility, making it effective in household and industrial cleaning applications.
n-Hexylglycol is used Industry, Scientific Research, Health, Environmental Protection, Agriculture

n-Hexylglycol can be used as solvent in specialty printing inks.
n-Hexylglycol is used as a high-boiling solvent.
n-Hexylglycol is used Clear, mobile, high-boiling, low-volatility liquid for use as a solvent, flow promoter and coalescent.
n-Hexylglycol is used by professional workers (widespread uses), consumers, in re-packing or re-formulation, in manufacturing, and at industrial sites.

Two solvents, n-Hexylglycol and diethylene glycol hexyl ether, are potential replacements for halogenated hydrocarbons in non-vapor degreasing applications.
n-Hexylglycol serves as a coalescing agent in cleaners and latex paints.
n-Hexylglycol is mainly used as solvents for cleaning fluids, paints, coatings and ink preparations.

ALTERNATIVE PARENTS of N-HEXYLGLYCOL:
*Primary alcohols
*Hydrocarbon derivatives

SUBSTITUENTS of N-HEXYLGLYCOL:
*Dialkyl ether
*Hydrocarbon derivative
*Primary alcohol
*Alcohol
*Aliphatic acyclic compound

PHYSICAL and CHEMICAL PROPERTIES of N-HEXYLGLYCOL:
Appearance and properties: transparent liquid
Density: 0.888 g/mL at 20 °C(lit.)
Boiling point: 98-99°C 0,15mm
Melting point: -45.1ºC
Flash point: 98-99°C/0.15mm
Refractive index: n20/D 1.431
Appearance: Colorless Clear Liquid
Content, GC%Wt: ≥98.0
Acidity,%Wt.(calculated as acetic acid): ≤0.01
Moisture,%Wt: ≤0.15
Chroma, Hazen unit (platinum-cobalt color number): ≤15
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Melting Point: -42°C

Flash point: 90 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,1 hPa at 22,9 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 0,888 g/mL at 20 °C
Relative density: No data available
Water solubility: 9,46 g/l - soluble
Partition coefficient: n-octanol/water:
log Pow: 1,97 at 25 °C
Autoignition temperature: 225 °C at 1.008 - 1.015 hPa
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Appearance (20°)C : Clear Liquid
Color (APHA or less) : 15
Specific gravity (20°C) : 0.887～0.892
Acidity (% or less) : 0.01
Water content (% or less) : 0.2
Purity (% or more) : 98
Molecular Weight: 146.23
XLogP3: 1.9

Boiling Point: 208°C
Flash Point: 94°C
Density: 0.89
Refractive Index: 1.43
Long-Term Storage: Store long-term in a cool, dry place
Appearance Form: liquid
Color: colorless
Odor: ether-like
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -50,1 °C at 1.013 hPa
Initial boiling point and boiling range: 208,5 °C at 1.013 hPa

Refractivity: 42.38 m³·mol⁻¹
Polarizability: 18.54 Å³
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
S.G @ 20C/20C: 0.887
Distillation Range C Min: 200
Distillation Range C Max: 212
Evaporation Rate Ether = 1: >1200
Flash Point Deg C: 92
Solubility % wt in Water: @ 20C 1
Dipole moment: (µ) 2.08 D
Solubility Mass fraction of Hexyl glycol in water: 1.0 %
Water in Hexyl glycol: 18.8 %
Water Solubility: 4.22 g/L
logP: 1.82
logP: 1.65
logS: -1.5
pKa (Strongest Acidic): 15.12
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 29.46 Å²
Rotatable Bond Count: 7

Molar mass 146.23 g/mol
n-Hexylglycol: 98.0 min. %
Water: 0.1 max. %
Pt/Co color value (Hazen): 10 max.
Acid value: 0.1 max mg KOH/g
Boiling range at 1013 hPa; 95 Vol.-%; 2 – 97 ml 200 – 212 °C
Density at 20 °C: 0.887 – 0.890 g/cm3
Refractive index: nD20 1.428 – 1.430
Solidification point: at 1013 hPa - 42 °C (ice flakes)
Evaporation rate ether: 1 approx. 1200
Enthalpy of combustion: at 25 °C 33 136 kJ/kg -
Enthalpy of vaporization: at 25 °C 475 kJ/kg -
Enthalpy of vaporization: at boiling point 325 kJ/kg
Enthalpy of formation: at 25 °C - 3 776 kJ/kg -

FIRST AID MEASURES of N-HEXYLGLYCOL:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing: make victim drink water.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-HEXYLGLYCOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.
Dispose of properly.

FIRE FIGHTING MEASURES of N-HEXYLGLYCOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-HEXYLGLYCOL:
-Control parameters
--Ingredients with workplace control parameters
-Exposure controls
--Personal protective equipment
*Eye/face protection
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Wash and dry hands.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-HEXYLGLYCOL:
-Precautions for safe handling:
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.

STABILITY and REACTIVITY of N-HEXYLGLYCOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available

SYNONYMS:
2-(n-Hexyloxy)ethanol
Ethylenglykolmonohexylether
2-(1-Hexyloxy) ethanol
EC 203-951-1
Ethylene glycol hexyl ether
SCHEMBL24741
4-01-00-02383
CHEMBL3188016
DTXSID1026908
DB-041064
FT-0631642
H0343
F71224
W-109065
Q27268660
Ethylene glycol monohexyl ether, BioXtra, >=99.0% (GC)
C6E1
2-(Hexyloxy)ethanol
Hexylglycol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
2-(Hexyloxy)ethanol
3-Oxa-1-nonanol
Ethanol, 2-(hexyloxy)- (6CI, 7CI, 8CI, 9CI)
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Glycol monohexyl ether
Hexyl CELLOSOLVE™ Solvent
Hexyl cellosolve
n-Hexyl Cellosolve
n-Hexylglykol
2-(HEXYLOXY)ETHANOL
2-N-(HEXYLOXY)ETHANOL
C6E1
ETHYLENE GLYCOL MONOHEXYL ETHER
ETHYLENE GLYCOL MONO-N-HEXYL ETHER
ETHYLENE GLYCOL N-HEXYL ETHER
HEXYLGLYCOL
N-HEXYL CELLOSOLVE
N-HEXYLMONOOXYETHYLENE
2-(hexyloxy)-ethano
2-Hexoxyethanol
2-hexyloxy-ethano
Cellosolve, n-hexyl-
ethyleneglycol-n-monohexylether
Glycol monohexyl ether
glycolmonohexylether
Hexyl cellosolve
hexylcellosolve
n-hexyl-cellosolv
Ethylenegylcolmono-N-hexylether

NIACINAMIDE; 3-Pyridinecarboxamide; Nicotinamide; Propamine A; Niacinamide; -Pyridinecarboxamide; Nicosylamide; Nicotamide; Nicotilamide; Nicotine acid amide; Nicotinic acid amide; Nicotinic amide; Nicotylamide; Nicovit; Nicovitina; Nikotinamid; Niocinamide; 3-Carbamoyl-pyridine; Vitamin B; Vitamin B3; 3-Carbamoylpyridine; 3-Pyridinecarboxylic acid amide; Picolinamide; Niamide; cas no: 98-92-0

Niacin (Vitamin B3) is slightly soluble in water and ethanol; nicotinamide is very soluble in water and moderately soluble in ethanol.
Niacin (Vitamin B3) deficiency is also associated with perosis in chickens as well as poor feathering of the birds.
Niacin (Vitamin B3) and nicotinamide are colorless crystalline substances.

CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
EINECS Number: 200-441-0

Niacin (Vitamin B3) can produce a variety of adverse effects, depending on the intake and health of the consumer.
Niacin (Vitamin B3) is frequently identified with the B complex vitamin grouping.
Early in the research on niacin, a nutritional niacin deficiency was identified as the cause of pellagra in humans, blacktongue in dogs, and certain forms of dermatosis in humans.

Niacin (Vitamin B3), Niacin or B3 is a water-soluble vitamin.
Derivatives of NADH, NADPH, NAD and NAD+ are a vitamin that has been affected in terms of energy, nuclear acids, protein fats and production.
Niacin (Vitamin B3) cannot be included in the term vitamin B3.

Niacin (Vitamin B3)s car boxyl group can form esters and anhydrides and can be reduced.
Both Niacin (Vitamin B3) and nicotinamide are very stable in dry form, but in solution nicotinamide is hydro lyzed by acids and bases to yield nicotinic.
The coenzyme forms of niacin are the pyridine nucleotides, NAD(H) and NADP(H).

The skin flushing reaction produced by Niacin (Vitamin B3) has been recognized for more than 70 years.
Niacin (Vitamin B3), melting point is 234-237℃.
In each of these compounds, the electron-withdrawing effect of the N-1 atom and the amide group of the oxidized pyridine nucleus enables the pyridine C-4 atom to react with many nucleophilic agents (e.g., sulfite, cyanide, and hydride ions).

Niacin (Vitamin B3) is the reaction with hydride ions (H?) that is the basis of the enzymatic hydrogen transfer by the pyridine nucleotides; the reaction involves the transfer of two electrons in a single step.
Several substituted pyridines are antagonists of niacin in biological systems: pyridine-3-sulfonic acid, 3-acetylpyridine, isoNiacin (Vitamin B3) hydrazine, 17 and 6-aminonicotinamide.
Niacin (Vitamin B3) is slightly soluble in water and ethanol; 100ml room temperature water can dissolve 1.6g.

When taken on an empty stomach, crystalline Niacin (Vitamin B3) in doses as small as 10 mg may produce a mild and transient, but noticeable, flushing reaction.
While not desirable, such reactions produce no known adverse consequences, and they are almost never perceptible when small amounts of Niacin (Vitamin B3) are taken in tablet or capsule form or consumed as part of food.
Niacin (Vitamin B3) was discovered by the oxidation of nicotine.

Niacin (Vitamin B3) is derived from Niacin (Vitamin B3) + vitamin, as the name to be given to it is not intended to evoke nicotine.
Niacin (Vitamin B3) can be seen in ancient texts that the name vitamin PP (short for the English term "pellegra prevention") was used for Niacin (Vitamin B3).
Niacin (Vitamin B3) is a B vitamin that's made and used by your body to turn food into energy.

Niacin (Vitamin B3) helps keep nervous system, digestive system and skin healthy.
Niacin (Vitamin B3) (vitamin B-3) is often part of a daily multivitamin, but most people get enough niacin from the food they eat.
Niacin (Vitamin B3) is sometimes referred to as Niacin (Vitamin B3) or nicotinamide and earlier called the P-P factor, antipellagra factor, antiblacktongue factor, and vitamin B4, niacin is available in several forms (niacin, niacinamide, niacinamide ascorbate, etc.) for use as a nutrient and dietary supplement.

Niacin (Vitamin B3), also known as niacin or vitamin B3, is a white crystal or crystalline powder, odorless or has a slight odor, slight sour taste.
Niacin (Vitamin B3) is easily soluble in hot water, hot ethanol, alkaline water, propylene glycol, and chloroform.
Niacin (Vitamin B3), or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.

The two most common forms of Niacin (Vitamin B3) in food and supplements are Niacin (Vitamin B3) and nicotinamide.
The body can also convert tryptophan—an amino acid—to nicotinamide.
Niacin (Vitamin B3) is water-soluble so that excess amounts the body does not need are excreted in the urine.

Niacin (Vitamin B3) works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Niacin (Vitamin B3) helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Niacin, also known as Niacin (Vitamin B3), is an organic compound and a vitamer of vitamin B3, an essential human nutrient.

Niacin (Vitamin B3) can be manufactured by plants and animals from the amino acid tryptophan.
Niacin (Vitamin B3) as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness.

Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide derivative Niacin (Vitamin B3) (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Although Niacin (Vitamin B3) and nicotinamide are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, it does not reduce cholesterol nor cause flushing.

Niacin (Vitamin B3) is recommended as a treatment for niacin deficiency because it can be administered in remedial amounts without causing the flushing, considered an adverse effect.
Niacin (Vitamin B3) (also known as vitamin B3) is one of the water-soluble B vitamins.
Niacin (Vitamin B3) is naturally present in many foods, added to some food products, and available as a dietary supplement.

Niacin (Vitamin B3) is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Niacin (Vitamin B3) has a role as an antidote, an antilipemic drug, a vasodilator agent, a metabolite, an EC 3.5.1.19 (nicotinamidase) inhibitor, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a plant metabolite.
Niacin (Vitamin B3) is a vitamin B3, a pyridinemonocarboxylic acid and a pyridine alkaloid.

Niacin (Vitamin B3) is a conjugate acid of a nicotinate.
Niacin (Vitamin B3), or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.
The two most common forms of Niacin (Vitamin B3) in food and supplements are Niacin (Vitamin B3) and nicotinamide.

The body can also convert tryptophan—an amino acid—to nicotinamide.
Niacin (Vitamin B3) is water-soluble so that excess amounts the body does not need are excreted in the urine.
Niacin (Vitamin B3) works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.

Niacin (Vitamin B3) helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Niacin (Vitamin B3) is also a prescription medication.
Niacin (Vitamin B3) is the generic name for Niacin (Vitamin B3) (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside.

Niacin (Vitamin B3) is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.
Niacin (Vitamin B3), on the other hand, is quite scarce in food and only recently started being sold as a supplement.
All three forms of vitamin B3 are converted to an important coenzyme called Niacin (Vitamin B3) in the body.

While not dangerous, Niacin (Vitamin B3) can be uncomfortable, or even alarming, if you aren’t prepared for it.
Niacin (Vitamin B3), also known as vitamin B3, is a water-soluble vitamin.
Water-soluble vitamins are stored in the body in very limited amounts and are excreted through the urine.

The Niacin (Vitamin B3) filter solutions are filled and immediately fused under controlled conditions to become permanently airtight.
Niacin (Vitamin B3) (NYE a sin) is used in combination with a healthy diet to lower bad cholesterol and increase good cholesterol.
Niacin (Vitamin B3) is also used to decrease triglycerides.

Niacin (Vitamin B3) can also be helpful in patients who have heart disease or who have had a heart attack.
Niacin (Vitamin B3) may be used for other purposes; ask your health care provider or pharmacist if you have questions.
Niacin (Vitamin B3) (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (Niacin (Vitamin B3) and nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

The two coenzymes are required for oxidative reactions crucial for energy production, but they are also substrates for enzymes involved in non-redox signaling pathways, thus regulating biological functions, including gene expression, cell cycle progression, DNA repair and cell death.
Therefore, Niacin (Vitamin B3) is a good idea to have them in your daily diet.
In addition to getting Niacin (Vitamin B3) from dietary sources, the body can synthesize a form of niacin from the amino acid tryptophan.

Niacin (Vitamin B3) causes the blood vessels to dilate or open up near the skin, which results in a hot, tingling sensation accompanied by a red flushing of the skin.
Generally, by starting with low amounts of Niacin (Vitamin B3) (50 to 100 mg a day) and gradually increasing the dosage, a person can quickly build up a tolerance and avoid the flush.
Taking Niacin (Vitamin B3) immediately following a meal will also lessen the flushing sensation.

Since Niacin (Vitamin B3) isn’t something that drug companies can patent, it’s of little interest to them.
Niacin (Vitamin B3), 3-pyridinecarboxylicacid (Niacin), is effective in the treatment of all types ofhyperlipoproteinemia except type I, at doses above thosegiven as a vitamin supplement.
Niacin (Vitamin B3) reduces VLDLsynthesis and, subsequently, its plasma products, IDL andLDL.

Plasma triglyceride levels are reduced because of thedecreased VLDL production.
Niacin (Vitamin B3) is found in all living cells, and it plays a vital role in energy metabolism and maintaining proper cell functioning — particularly the functioning of our mitochondria, the power plants in our cells that turn food and oxygen into energy.

Niacin (Vitamin B3) also plays an important role in protecting cells all over the body from age-related damage and decline in function.
While all three forms of vitamin B3 share common traits, each has a slightly different effect on the body and serves a different role when taken as a supplement.
Niacin (Vitamin B3) (or Niacin (Vitamin B3) as it’s referred to in medical circles) was the third B vitamin to be discovered (hence the name B3).

Melting point: 236-239 °C(lit.)
Boiling point: 260C
Density: 1.473
refractive index: 1.5423 (estimate)
Flash point: 193°C
storage temp.: 2-8°C
solubility: 18g/l
pka: 4.85(at 25℃)
form: Powder
color: White to off-white
PH: 2.7 (18g/l, H2O, 20℃)
Odor: odorless to sl. odor, sour taste
Water Solubility: 1-5 g/100 mL at 17 ºC
Merck: 14,6525
BRN: 109591
BCS Class: 3
Stability: Stable. Incompatible with strong oxidizing agents. May be light sensitive.
InChIKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
LogP: 0.360

Niacin (Vitamin B3) wasn’t until about 1943, though, that a couple of doctors reported that niacin worked wonders in relieving the pain and stiffness associated with arthritis.
Niacin (Vitamin B3) excess cholesterol is then excreted throughthe biliary tract.
Niacin (Vitamin B3), also known as B3, Niacin (Vitamin B3) or nicotinamide, is an important enzymatic component required for the body to function normally.

This vitamin allows us to obtain energy from macronutrients (carbohydrates and fats).
Niacin (Vitamin B3) has a unique characteristic.
Niacin (Vitamin B3), a very important micronutrient for energy synthesis, also contributes to the healthy functioning of the nervous and digestive systems.

In addition to these, Niacin (Vitamin B3) is known that it is good for skin health and vitality, hair and eyes.
Niacin (Vitamin B3), an enzymatic component, has an important role in the metabolism of fats and sugars.
In this way, cells have the ability to provide the energy they need to continue their normal functions.

Since Niacin (Vitamin B3) helps regulate fat and cholesterol levels, it can be used for the prevention or treatment of cardiovascular ailments.
Niacin (Vitamin B3), also called Niacin (Vitamin B3) and vitamin B3, water-soluble vitamin of the B complex.
Niacin (Vitamin B3) is also called the pellagra-preventive vitamin because an adequate amount in the diet prevents pellagra, a chronic disease characterized by skin lesions, gastrointestinal disturbance, and nervous symptoms.

Niacin (Vitamin B3) is interchangeable in metabolism with its amide, niacinamide (nicotinamide).
Like the vitamins thiamin (vitamin B1) and riboflavin (vitamin B2), niacin functions as part of a coenzyme involved in the metabolism of carbohydrates and acts to catalyze the oxidation of sugar derivatives and other substances.
Niacin (Vitamin B3), which was identified as a pellagra preventive in 1937, is widely distributed among plants and animals.

Niacin (Vitamin B3) approximately 15 mg per day (1 mg = 0.001 gram) of Niacin (Vitamin B3) is required by humans.
In the intestinal tract, the Niacin (Vitamin B3) tryptophan can be converted to niacin by bacterial action and thus can serve as a source for part of the required Niacin (Vitamin B3).
This explains scientists’ early observation that the protein in such foods as eggs and milk, both poor sources of niacin, can nevertheless prevent or cure pellagra.

Niacin (Vitamin B3) is indicated to prevent vitamin deficiencies in pediatric and adult patients receiving parenteral nutrition as part of multivitamin intravenous injections.
Niacin (Vitamin B3) oral tablets are indicated as a monotherapy or in combination with simvastatin or lovastatin to treat primary hyperlipidemia and mixed dyslipidemia.
Niacin (Vitamin B3) can also be used to reduce the risk of nonfatal myocardial infarctions in patients with a history of myocardial infarction and hyperlipidemia.

Niacin (Vitamin B3) use of supplements containing niacin may be beneficial in terms of weight loss, as the substance will stimulate energy synthesis and help reduce the feeling of fatigue caused by weight loss.
Niacin (Vitamin B3) also positively affects the vitality and health of the skin, eyes and hair and can be used for the treatment of skin conditions such as dermatitis, skin irritation and acne.
Adequate consumption of niacin contributes to the strengthening of the digestive and immune systems, while helping to fight oxidative stress.

Niacin (Vitamin B3) also has positive effects on the health of the nervous system (it triggers units related to cognitive functions and memory).
Niacin (Vitamin B3) deficiency can cause serious symptoms such as muscle weakness, digestive upsets (irritation of the mucus layer in the mouth, stomach, and intestines), loss of appetite, and skin rashes.
In more severe cases, Niacin (Vitamin B3) can cause lesions in the central nervous system, leading to confusion and disorientation.

Studies have shown that Niacin (Vitamin B3) can significantly lower cholesterol levels, but because the product is inexpensive, the pharmaceutical industry has not commercialized this supplement as a combined treatment for hypercholesteremia.
Niacin (Vitamin B3) is amphoteric and forms salts with acids as well as bases.
Niacin (Vitamin B3) is also indicated with bile acid binding resins to treat atherosclerosis in patients with coronary artery disease and hyperlipidemia or to treat primary hyperlipidemia.

Niacin (Vitamin B3) decreases formation and secretion of VLDL by the liver.
This action appears secondary to its ability to inhibit fatty acid mobilization from adipose tissue.
Circulating free fatty acids provide the main source of fatty acids for hepatic triglyceride synthesis, and lowering triglyceride synthesis lowers Niacin (Vitamin B3) formation and secretion by the liver.

Niacin (Vitamin B3) shifts LDL particles to larger (more buoyant) sizes.
The larger LDL particles are thought to be less atherogenic.
Niacin (Vitamin B3) can also significantly increase plasma HDL levels; the mechanism is unknown.

Niacin (Vitamin B3) is also known as vitamin B3, one of the B-complex vitamins.
Vitamins help to support the body's ability to make and break down natural compounds (metabolism) needed for good health.
Niacin (Vitamin B3) (nicotinamide) is a different form of vitamin B3 and does not work the same as niacin.

Niacin (Vitamin B3) is both a vitamin, i.e., an essential nutrient, marketed as a dietary supplement, and in the US, a prescription medicine.
As a Niacin (Vitamin B3), it is precursor of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).
Severe deficiency of Niacin (Vitamin B3) in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death.

Common psychiatric symptoms include irritability, poor concentration, anxiety, fatigue, loss of memory, restlessness, apathy, and depression.
Finally Niacin (Vitamin B3) is indicated to treat severe hypertriglyceridemia.
Niacin (Vitamin B3) is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.

Niacin (Vitamin B3) acts to decrease levels of very low density lipoproteins and low density lipoproteins, while increasing levels of high density lipoproteins.
Niacin (Vitamin B3) can be converted to nicotinamide in the animal body and, in this form, is found as a component of two oxidation-reduction coenzymes, NAD and NADP.
Niacin (Vitamin B3) is taken by mouth for high cholesterol and other fats.

Niacin (Vitamin B3) is also used for low levels of a specific type of cholesterol, HDL.
Niacin (Vitamin B3) is also used along with other treatments for circulation problems, migraine headache, Meniere's syndrome and other causes of dizziness, and to reduce the diarrhea associated with cholera.
Niacin (Vitamin B3) is also taken by mouth to for preventing positive urine drug screens in people who take illegal drugs.

Niacin (Vitamin B3) is taken by mouth for preventing vitamin B3 deficiency and related conditions such as pellagra.
Niacin (Vitamin B3) is also taken by mouth for schizophrenia, hallucinations due to drugs, Alzheimer's disease and age-related loss of thinking skills, chronic brain syndrome, muscle spasms, depression, motion sickness, alcohol dependence, blood vessel swelling linked with skin lesions, and fluid collection (edema).
Some people take Niacin (Vitamin B3) by mouth for acne, leprosy, attention deficit-hyperactivity disorder (ADHD), preventing premenstrual headache, improving digestion, protecting against toxins and pollutants, reducing the effects of aging, arthritis, lowering blood pressure, improving circulation, promoting relaxation, improving orgasms, and preventing cataracts.

Niacin (Vitamin B3) is a member of the B family of vitamins (B complex).
Niacin (Vitamin B3)a water-soluble vitamin.
Like the other B vitamins, Niacin (Vitamin B3) helps make energy in your body.

Niacin (Vitamin B3) helps your body use carbohydrates, fatty acids, and proteins.
Niacin (Vitamin B3) is found in many plant and animal foods, such as yeast, meats (especially liver), grains, legumes, corn treated with alkali (such as corn used in tortillas), and seeds.
Niacin (Vitamin B3) can be made by the liver from the amino acid tryptophan.

Niacin (Vitamin B3) can be manufactured by plants and animals from the amino acid tryptophan.
Niacin (Vitamin B3) is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.
Niacin (Vitamin B3) as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.

Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide derivative Niacin (Vitamin B3) (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Niacin (Vitamin B3) is also used to improve exercise performance.

Niacin (Vitamin B3) is a water-soluble vitamin that cannot be stored in body fat.
Niacin (Vitamin B3) has two active components, Niacin (Vitamin B3) (niacin) and nicotinamide (niacinamide).

Niacin (Vitamin B3) plays a role in over 200 enzymatic reactions.
The nicotinamide portion of the coenzyme transfers hydrogens by alternating between an oxidized quaternary nitrogen and a reduced tertiary nitrogen.

History:
Huber first synthesized Niacin (Vitamin B3) in 1867. In 1914, Funk isolated Niacin (Vitamin B3) from rice polishings.
Goldberger, in 1915, demonstrated that pellagra is a nutritional deficiency.
In 1917, Chittenden and Underhill demonstrated that canine blacktongue is similar to pellagra.

In 1935, Warburg and Christian showed that niacinamide is essential in hydrogen transport as diphosphopyridine nucleotide (DPN).
In the following year, Euler et al. isolated DPN and determined its structure.
In 1937, Elvhehjem et al. cured blacktongue by administration of Niacin (Vitamin B3) derived from liver.

In the same year, Fouts et al. cured pellagra with niacinamide.
In 1947, Handley and Bond established conversion of tryptophan to niacin by animal tissues
Carpenter found in 1951, that niacin in corn is biologically unavailable, and can be released only in very alkaline lime water of pH 11.

This explains why a Latin-American culture that used alkali-treated cornmeal to make tortilla was not at risk for niacin deficiency.
In 1955, Altschul and colleagues described large amounts of niacin as having a lipid-lowering property.

As such, Niacin (Vitamin B3) is the oldest known lipid-lowering drug.
Lovastatin, the first 'statin' drug, was first marketed in 1987.

Mechanisms:
Niacin (Vitamin B3) reduces synthesis of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), lipoprotein(a) and triglycerides, and increases high-density lipoprotein cholesterol (HDL-C).
The lipid-therapeutic effects of niacin are partly mediated through the activation of G protein-coupled receptors, including hydroxycarboxylic acid receptor 2 (HCA2)and hydroxycarboxylic acid receptor 3 (HCA3), which are highly expressed in body fat.

HCA2 and HCA3 inhibit cyclic adenosine monophosphate (cAMP) production and thus suppress the release of free fatty acids (FFAs) from body fat, reducing their availability to the liver to synthesize the blood-circulating lipids in question.
A decrease in free fatty acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL-C turnover and reducing its production.
Niacin (Vitamin B3) also directly inhibits the action of diacylglycerol O-acyltransferase 2 (DGAT2) a key enzyme for triglyceride synthesis.

Preparation:
Niacin (Vitamin B3) exists naturally in grain germs, meats and peanuts.
Niacin (Vitamin B3) can also be synthesized artificially through the liquid phase method (potassium permanganate oxidation and nitric acid oxidation) and gas phase method (ozone oxidation, ammonia oxidation and air oxidation).
In the gas phase ammonia oxidation process, add 3-methyl pyridine, air and ammonia into the fluidized bed reactor and catalyze the reaction at 290～360℃,V2O5 to produce nicotinonitrile; then hydrolyze in sodium hydroxide aqueous solution at 160℃ to produce sodium nicotinate; finally, add hydrochloric acid to acidify, creating Niacin (Vitamin B3).

In the potassium permanganate oxidation method, add potassium permanganate gradually at 80℃ to a mixture of 3-methyl pyridine and water, and then continue to mix for 30min at 85～90℃.
Distill to collect and reuse the unreacted 3-methyl pyridine and filter away the produced manganese dioxide.
Adjust the PH of the resulting Niacin (Vitamin B3) solution to 3.8～4.0 using hydrochloric acid, cool to 30℃ crystals, and filter to obtain crude Niacin (Vitamin B3).

Dissolve the crude Niacin (Vitamin B3) in hot water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
6- hydroxyquinoline method Add sulfuric acid and quinoline into a reaction kettle and mix while maintaining heat at 150～160℃ for 5h.
Then with the temperature maintained at 180～220℃, slowly drop in nitric acid and the sulfuric acid mixture over the course of 36～40h.

While maintaining the temperature, mix for 2～3h to obtain a Niacin (Vitamin B3) solution and add water to dilute the solution.
Use 30％～33％ NaOH solution to neutralize the PH to 8～9.
Cool and filter away the sodium sulfate and sodium nitrate crystals, add copper sulfate solution to the filtered liquid, and mix and heat to yield copper nicotinate precipitation.

Cool, filter and add the copper nicotinate to an adequate amount of water, drop in NaOH solution until PH>9 and the liquid is no longer blue, and filter away the produced cupric oxide.
Add a small amount of sodium sulfide solution to remove traces of copper and iron until the solution no longer produces black precipitate, and then filter.
Use hydrochloric acid to adjust the PH of the filtered liquid to 3.5～3.9, filter to yield crystals as crude Niacin (Vitamin B3).

Dissolve the crude product in 12 times the amount of distilled water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
Yield is 35％～39％.
2-methyl-5-ethyl pyridine method With 2-methyl-5-ethyl pyridine as the raw ingredient, oxidize with nitic acid under high pressure and high temperatures, then decarboxylate to yield Niacin (Vitamin B3).

Uses:
Niacin (Vitamin B3) is used as a medication to help lower elevated levels of LDL (low-density lipoprotein) cholesterol and triglycerides in the blood while increasing HDL (high-density lipoprotein) cholesterol.
Niacin (Vitamin B3) can help address issues like acne, dry skin, and skin aging.
Niacin (Vitamin B3) has been used in the prevention of migraines, although its effectiveness can vary from person to person.

Some studies have suggested that niacin supplementation may help improve certain symptoms of schizophrenia when used in combination with other medications.
Niacin (Vitamin B3) is involved in various metabolic processes in the brain and may play a role in maintaining cognitive function.
Some research has explored its potential in Alzheimer's disease and age-related cognitive decline, though results are inconclusive.

High-dose Niacin (Vitamin B3) has been used in certain detoxification programs for individuals trying to eliminate traces of illicit drugs, particularly marijuana, from their system.
This approach is controversial and should only be done under medical supervision.
Niacin (Vitamin B3) is a crucial component in the production of energy within cells. It helps convert food into energy and is involved in various metabolic pathways.

Niacin (Vitamin B3) has been shown to lower levels of Lp(a) cholesterol, which is associated with an increased risk of cardiovascular disease.
Niacin (Vitamin B3) can be used in specific cases to target elevated Lp(a) levels.
Niacin (Vitamin B3) is often prescribed for individuals with high cholesterol or those at risk of heart disease.

Due to its cholesterol-lowering properties, Niacin (Vitamin B3) can be prescribed to reduce the risk of heart attacks and strokes in certain patients with cardiovascular disease.
Niacin (Vitamin B3) is sometimes used to treat hyperlipidemia, a condition characterized by high levels of lipids (fats) in the blood.
Niacin (Vitamin B3) can also be used to manage dyslipidemia, a condition involving abnormal lipid levels in the blood, including high LDL cholesterol and triglycerides.

In some cases, Niacin (Vitamin B3) may be used to improve blood circulation in people with certain vascular conditions, like intermittent claudication, a symptom of peripheral arterial disease.
Niacin (Vitamin B3) is sometimes used topically or in skincare products to improve the health and appearance of the skin.
Niacin (Vitamin B3) is an important factor in delivering hydrogen and fighting pellagra in organisms; it helps maintain skin and nerve health and stimulate digestion.

Niacin (Vitamin B3) or niacinamide are used to treat and prevent pellagra.
This is a disease caused by niacin deficiency.
Niacin (Vitamin B3) is also used to treat high cholesterol.

In some cases, niacin taken with colestipol can work as well as colestipol and a statin medicine.
Niacin (Vitamin B3) USP granular is used for food fortification, as dietary supplement and as an intermediate of pharmaceuticals.
Niacin (Vitamin B3) feed grade is used as vitamin for poultry, swines, ruminants, fish, dogs and cats, etc.

Niacin (Vitamin B3) is also used as intermediate for Niacin (Vitamin B3) derivatives and technical applications.
Niacin (Vitamin B3) is used to prevent and treat niacin deficiency (pellagra).
Niacin (Vitamin B3) deficiency may result from certain medical conditions (such as alcohol abuse, malabsorption syndrome, Hartnup disease), poor diet, or long-term use of certain medications (such as isoniazid).

Niacin (Vitamin B3), a form of niacin, is used in skincare products to address various skin conditions, such as acne, rosacea, and hyperpigmentation.
Niacin (Vitamin B3) can help improve the appearance and texture of the skin.
Niacin (Vitamin B3) has anti-inflammatory properties and is used in skincare products to soothe and calm irritated skin.

Niacin (Vitamin B3) may also help reduce redness associated with certain skin conditions.
In addition to treating pellagra caused by niacin deficiency, Niacin (Vitamin B3) can sometimes be used to alleviate pellagra-like conditions that may result from other medical conditions or medications.
Niacin (Vitamin B3) deficiency can cause diarrhea, confusion (dementia), tongue redness/swelling, and peeling red skin.

Niacin (Vitamin B3) is also known as niacin and vitamin B3.
Niacin (Vitamin B3) is a water-soluble conditioning agent that improves rough, dry, or flaky skin, helping smooth the skin and improve its suppleness.

Niacin (Vitamin B3) enhances the appearance and feel of hair, by increasing body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
When used in the formulation of skin care products, niacinamide and niacin enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness.
Niacin (Vitamin B3) is a precursor of the coenzymes NAD and NADP.

Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains.
Niacin (Vitamin B3) is a water-soluble b-complex vitamin that is necessary for the growth and health of tissues.
Dietary deficiency is associated with pellagra.

Niacin (Vitamin B3) was functions as a nutrient and dietary supplement that prevents pellagra.
The term "Niacin (Vitamin B3)" has also been applied.

Safety Profile:
Niacin (Vitamin B3)v poison by intraperitoneal route.
Niacin (Vitamin B3), questionable carcinogen with experimental carcinogenic data.
When heated to decomposition it emits toxic fumes of NOx.

Moderately toxic by ingestion, intravenous, and subcutaneous routes.
Human systemic effects: change in clotting factors, changes in platelet count.

Synonyms:
Niacin (Vitamin B3)
niacin
59-67-6
Pyridine-3-carboxylic acid
3-pyridinecarboxylic acid
3-Carboxypyridine
wampocap
vitamin B3
Niaspan
Acidum nicotinicum
nicolar
Apelagrin
Pellagrin
Akotin
Daskil
Efacin
Pelonin
Linic
nicamin
nicobid
nicocap
Enduracin
Nicodelmine
Niconacid
Nicotinipca
Pellagramin
Direktan
Nicacid
Nicangin
Peviton
Bionic
Diacin
Nicyl
Nyclin
Niac
Vitaplex N
Davitamon PP
Nico-Span
Tega-Span
Nicocidin
Nicocrisina
Niconazid
Nicotamin
Nicotene
Nicovasan
Nicovasen
Nipellen
SK-Niacin
Naotin
Niacor
Nicodon
Niconat
Nicosan 3
Nicosyl
Nicotil
Tinic
3-Carboxylpyridine
Nicotine acid
Nicodan
Nicoside
Slo-niacin
NICO
3-Picolinic acid
Nicotinsaure
Nico-400
Acide nicotinique
Pyridine-beta-carboxylic acid
Nicagin
anti-Pellagra vitamin
Caswell No. 598
PP Factor
Kyselina nikotinova
P.P. factor
Pellagra preventive factor
S115
Nicotinsaure [German]
Acido nicotinico
3-Pyridylcarboxylic acid
m-Pyridinecarboxylic acid
Niacin [USAN]
Kyselina nikotinova [Czech]
C6H5NO2
MFCD00006391
niacine
CCRIS 1902
Pyridine-carboxylique-3
EPA Pesticide Chemical Code 056701
Acide nicotinique [INN-French]
Acido nicotinico [INN-Spanish]
Acidum nicotinicum [INN-Latin]
HSDB 3134
Pyridine-carboxylique-3 [French]
AI3-18994
Pyridinecarboxylic acid, 3-
Niacin [USP]
SR 4390
BRN 0109591
Niacin extended release
Niacin (Vitamin B3) [INN]
Vitamin B3 (Niacin)
Niacin (Niacin (Vitamin B3))
EINECS 200-441-0
NIASPAN TITRATION STARTER PACK
NAH
CHEMBL573
beta-pyridinecarboxylic acid
NSC 169454
NSC-169454
niacin magnesium
niacin potassium
MLS000069603
Pyridine-.beta.-carboxylic acid
DTXSID1020932
UNII-2679MF687A
CHEBI:15940
Niacin (USP)
Niacinamide (TN)
2679MF687A
P.P. factor-pellagra preventive factor
Nicotinamide (TN)
CAS-59-67-6
NCGC00016268-02
Niacin (TN)
SMR000059024
[3H]Niacin (Vitamin B3)
[5, 6-3H]-niacin
EC 200-441-0
[3H]-Niacin (Vitamin B3)
5-22-02-00057 (Beilstein Handbook Reference)
DTXCID10932
Nicotinicacid
Induracin
SR-01000722017
pellagra
Nikotinsaeure
Ncotnc acd
preventative factor
Niacin-Vitamin B3
Niaspan (TN)
3PyrCOOH
Niacor (TN)
Niacin (Vitamin B3),(S)
Niacinamide Astra Brand
Niacinamide Merck Brand
Spectrum_001063
Niacin (Vitamin B3), Ph Eur
NIACIN [VANDF]
NIACIN [HSDB]
NIACIN [INCI]
5-pyridinecarboxylic acid
NIACIN [FCC]
NIACIN [USP-RS]
Opera_ID_1346
Prestwick0_000881
Prestwick1_000881
Prestwick2_000881
Prestwick3_000881
Pyridine-3-carbonic acid
Spectrum2_000006
Spectrum3_000515
Spectrum4_000965
Spectrum5_001287
VITAMIN B-3
3-Pyridyl carboxylic acid
Niacin (Vitamin B3)-d3(major)
Nicotinamide-carbonyl-14C
Niacin (Vitamin B3); (Niacin)
WLN: T6NJ CVQ
3-pyridine carboxylic acid
Astra Brand of Niacinamide
bmse000104
D06NVJ
Merck Brand of Niacinamide
Niacinamide Jenapharm Brand
Niacin (Vitamin B3), >=98%
Niacin (Vitamin B3), USP grade
SCHEMBL1433
Nicotinamide (JP15/INN)
Niacin (Vitamin B3) [INN:BAN]
Niacin (Vitamin B3); (Niacin)
Niacin (Vitamin B3) [MI]
Niacinamide Pharmagenix Brand
Oprea1_514398
VITAMIN B3 [VANDF]
BSPBio_000662
BSPBio_002069
KBioGR_001309
KBioSS_001543
NIACIN [ORANGE BOOK]
Niacin (Vitamin B3) [JAN]
Niacin (Vitamin B3) (Vitamin B3)
BIDD:GT0644
DivK1c_000695
Niacin (Vitamin B3) (JP17/INN)
SIMCOR COMPONENT NIACIN
SPECTRUM1500430
.beta.-Pyridinecarboxylic acid
Jenapharm Brand of Niacinamide
SPBio_000011
SPBio_002881
ADVICOR COMPONENT NIACIN
NIACIN [USP MONOGRAPH]
Niacin (Vitamin B3) [VANDF]
BPBio1_000730
GTPL1588
GTPL1594
Niacin (Vitamin B3) [MART.]
Niacin (Vitamin B3) [WHO-DD]
Niacin (Vitamin B3) [WHO-IP]
Pharmagenix Brand of Niacinamide
BDBM23515
HMS502C17
KBio1_000695
KBio2_001543
KBio2_004111
KBio2_006679
KBio3_001569
ABT-919
NIACIN COMPONENT OF SIMCOR
Niacin (Vitamin B3) [EMA EPAR]
NINDS_000695
HMS1570B04
HMS1920P17
HMS2091H22
HMS2097B04
HMS2236A05
HMS3259K21
HMS3371E07
HMS3655K08
HMS3714B04
NIACIN COMPONENT OF ADVICOR
Pharmakon1600-01500430
Niacin (Vitamin B3), analytical standard
BCP16301
HY-B0143
STR00112
Tox21_110337
Tox21_201420
Tox21_302904
AC8691
BBL037343
CCG-38340
Niacin (Vitamin B3) [EP IMPURITY]
Niacin (Vitamin B3), for synthesis, 99%
NSC169454
NSC757241
s1744
STK301803
Niacin (Vitamin B3) [EP MONOGRAPH]
AKOS000118980
Niacin (Vitamin B3), >=99.5% (HPLC)
Tox21_110337_1
AM81316
CS-1946
DB00627
LS-2334
NC00524
Niacin (Vitamin B3) 1.0 mg/ml in Methanol
NSC-757241
PS-4255
SDCCGMLS-0066610.P001
IDI1_000695
NCGC00016268-01
NCGC00016268-03
NCGC00016268-04
NCGC00016268-05
NCGC00016268-08
NCGC00016268-09
NCGC00094734-01
NCGC00094734-02
NCGC00256537-01
NCGC00258971-01
AC-22484
ACIDUM NICOTINICUM [WHO-IP LATIN]
BP-21419
NCI60_001041
Niacin (Vitamin B3), NIST(R) SRM(R) 148
Niacin (Vitamin B3), plant cell culture tested
SY011111
SBI-0051456.P003
Niacin (Vitamin B3) [Matrix for MALDI-TOF/MS]
AB00052050
FT-0600004
FT-0672715
FT-0672716
FT-0672717
FT-0672718
FT-0773496
N0082
N1103
Niacin (Vitamin B3) 10 microg/mL in Acetonitrile
Niacin (Vitamin B3), purum, >=99.0% (HPLC)
SW197229-3
EN300-16693
C00253
D00049
Niacinamide, Niacin (Vitamin B3) amide, Nicotinamide
Niacin (Vitamin B3), SAJ special grade, >=99.5%
AB00052050-13
AB00052050_14
AB00052050_15
Niacin (Vitamin B3), meets USP testing specifications
AC-907/25014105
L001199
METHYL NICOTINATE IMPURITY A [EP IMPURITY]
Niacin (Vitamin B3), Vetec(TM) reagent grade, >=98%
Q134658
J-523605
SR-01000722017-2
SR-01000722017-3
SR-01000722017-4
Z56755709
3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E
F2191-0082
Niacin, United States Pharmacopeia (USP) Reference Standard
Niacin (Vitamin B3), certified reference material, TraceCERT(R)
Niacin (Vitamin B3), European Pharmacopoeia (EP) Reference Standard
Niacin (Vitamin B3), matrix substance for MALDI-MS, >=99.5% (HPLC)
InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9
Niacin (Vitamin B3), for inorganic trace analysis, >=99.999% (metals basis)
Niacin (Niacin (Vitamin B3)), Pharmaceutical Secondary Standard; Certified Reference Material
101113-41-1
Niacin (Vitamin B3), BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98%

Niacinamide is a form of vitamin B3(niacin), a water-soluble vitamin; used in cosmetics and personal care products as a conditioning agent.
Niacinamide, also called nicotinamide, is a form of vitamin B3.
Niacinamide's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

CAS Number: 98-92-0
EC Number: 202-713-4
MDL number: MFCD00006395
Empirical Formula (Hill Notation): C6H6N2O

Niacinamide, also called nicotinamide, is a form of vitamin B3.
Niacinamide's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.
Niacinamide is required for the function of fats and sugars in the body and to maintain healthy cells.

Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Unlike niacin, niacinamide doesn't help treat high cholesterol.
Do not confuse niacinamide with niacin, NADH, nicotinamide riboside, inositol nicotinate, or L-tryptophan.

These are not the same.
Niacinamide, or nicotinamide, is a type of vitamin B-3.
Taking Niacinamide can help prevent B-3 deficiency and may treat acne and eczema.

More research is needed, however.
Preventing B-3 deficiency is important because it can lead to disorders of the skin, kidneys, and brain.
But, there’s much more to niacinamide, especially when it comes to general skin health.

Despite the similarities in names, niacinamide isn’t the same thing as niacin.
They’re two different types of vitamin B-3.
However, your body can make niacinamide from niacin supplements you’ve taken.

This happens when there’s an excessive amount of niacin in the body.
Tryptophan in the body can also be converted into niacinamide.
Niacinamide is a form of vitamin B3, which your body needs to help maintain healthy-looking skin.

There are three forms of vitamin B3—niacinamide (nicotinamide), niacin (nicotinic acid), and nicotinamide riboside—but niacinamide is the ingredient that’s most popularly used in skincare products.
Vitamin B3 can be found in niacin-rich foods, such as fish, poultry, grains, nuts, and legumes.

Niacinamide is not produced naturally by your body, so in order to gain the benefits of niacinamide for skin, you’ll need to seek out external sources—such as skincare products formulated with niacinamide.
Niacinamide or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.

Niacinamide is in the vitamin B family of medications, specifically the vitamin B3 complex.
Niacinamide is an amide of nicotinic acid.
Foods that contain niacinamide include yeast, meat, milk, and green vegetables.

Niacinamide was discovered between 1935 and 1937.
Niacinamide is on the World Health Organization's List of Essential Medicines.
Niacinamide is available as a generic medication and over the counter.

Commercially, niacinamide is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries grains have niacinamide added to them.
Although the word Niacinamide may sound a little scary, it’s basically Vitamin B3, an essential nutrient for your skin.

This is why Niacinamide can help your skin look healthier.
Niacinamide, also called nicotinamide, is a form of vitamin B3.
Niacinamide's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

Niacinamide is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Unlike niacin, niacinamide doesn't help treat high cholesterol.

Niacinamide is a type of vitamin B3, one of eight B vitamins that support many aspects of your health.
Your body makes niacinamide when you have too much niacin in your body.
Your body can also change an amino acid called tryptophan into niacinamide.

Niacinamide can prevent pathological changes of skin and diseases of alimentary canal, such as dermatitis, black tongue, vomiting and diarrhea etc.
By participating in material and energy metabolism, Niacinamide CAS 98-92-0 can promote the body growth.
By combining with other medicines, Niacinamide can cure catarrh and ulcer.

By improving the ability of blood supply with strong expansion function of blood vessel, Niacinamide is highly effective in curing such diseases as dermatosis, hypercholesterolemia disease and coronary heart disease.
Also known as Vitamin B3, this lab-born ingredient is a major multi-tasker.

For context: Niacinamide works to support skin’s barrier while it also helps to brighten dull-looking skin.
Niacinamide (nicotinamide) is a form of vitamin B3.
"Vitamin B3" can mean niacinamide (nicotinamide) or nicotinic acid (niacin).

Some companies may label Niacinamide and nicotinic acid as "niacin." However, niacin and niacinamide are different forms of vitamin B3.
They have different chemical structures that work differently in your body.
For example, niacinamide doesn't reduce cholesterol levels like niacin.

Niacinamide is a water-soluble vitamin, meaning it's not stored in the body.
You need to consume it through food or supplements.
Your body needs niacinamide to create energy.

Your cells need it to function correctly.
Niacinamide might not get quite as much buzz as ingredients like retinol and vitamin C, but the skincare superstar is an unsung hero that deserves equal praise.

Niacinamide's the very definition of a multitasker—it's even found in many of the best drugstore shampoos—offering a litany of different benefits that make it a great pick for a wide variety of skin types and complexion concerns.
Niacinamide appears as an active ingredient in several affordable skincare brands.

Niacinamide is often dubbed as the all-rounder hero in many skincare routines.
Niacinamide holds countless benefits for all different skin types, so it’s not hard to see why everyone is obsessed.
But if you’re wondering what is niacinamide and what does niacinamide do, we’ve got all the answers for you.

Keep reading to find out all the deets.
Niacinamide is also known as vitamin B3 and is a water-soluble vitamin that works with your skin’s natural oils and vitamins to achieve results.
It’s an essential nutrient for your skin, which is why many people experience noticeable results once they add niacinamide to their routine.

Niacinamide, also known as nicotinamide, is a form of Vitamin B3 (niacin).
Niacinamide is water-soluble, meaning that it is not stored in the body, so it's crucial to replenish our niacinamide reserves orally via the food we eat (poultry, green vegetables and eggs are good sources), and topically with targeted skincare products.

While you can get sources of vitamin B3 through your diet, topical application can accelerate the benefits.
Niacinamide sounds like a beauty brand’s chemistry-lab invention (just us?), but the increasingly popular skin-care ingredient is actually just a form of vitamin B3.

USES and APPLICATIONS of NIACINAMIDE:
People use niacinamide to prevent vitamin B3 deficiency and related conditions such as pellagra.
Niacinamide is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

Also known as vitamin B3 and nicotinamide, niacinamide is a water-soluble vitamin that works with the natural substances in your skin to help visibly minimize enlarged pores, tighten lax or stretched out pores, improve uneven skin tone, soften fine lines and wrinkles, diminish dullness, and strengthen a weakened surface.

Niacinamide also reduces the impact of environmental damage because of its ability to improve skin’s barrier (its first line of defense), plus it also plays a role in helping skin to repair signs of past damage.
Left unchecked, this type of daily assault makes skin appear older, dull and less radiant.

Niacinamide, also known as vitamin B3 or nicotinamide, is a water-soluble B vitamin that plays an important —in cleansers eye creams, serums, and sunscreens.
When used as part of your daily skincare regimen, niacinamide may help calm your skin, reduce transepidermal water loss (TEWL), and increase moisture in your skin’s uppermost layer.

This makes niacinamide a helpful skincare ingredient for those looking to promote hydrated, even-toned skin.
First studied for its skincare benefits in the 1970s, niacinamide has since become a popular cosmetic ingredient in formulations for multiple skin types and skin concerns.

As a supplement, Niacinamide is used by mouth to prevent and treat pellagra (niacin deficiency).
While nicotinic acid (niacin) may be used for this purpose, niacinamide has the benefit of not causing skin flushing.
As a cream, Niacinamide is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.

Niacinamide is a water-soluble vitamin.
Niacinamide is the supplement name while nicotinamide is the scientific name.
Skin cancer: Niacinamide at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.

Niacinamide can be found in vitamin-rich foods, such as kale, mushrooms and almonds, which help take great care of your body from the inside, as well as in skin care products to pamper it from the outside.
People use niacinamide to prevent vitamin B3 deficiency and related conditions such as pellagra.

Niacinamide is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

Niacinamide is a form of vitamin B3(niacin), a water-soluble vitamin; used in cosmetics and personal care products as a conditioning agent.
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider.
No supplement is intended to treat, cure, or prevent disease.

-Medical uses:
*Niacin deficiency:
Niacinamide is the preferred treatment for pellagra, caused by niacin deficiency.

-Acne:
Niacinamide cream is used as a treatment for acne.
Niacinamide has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Niacinamide increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.
The application of 2% topical niacinamide for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Niacinamide has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.

WHERE SHOULD I USE NIACINAMIDE?
If you’ve made it to this point, chances are you’re sold on adding niacinamide into your routine.
But you might have some questions.
How should you use niacinamide?

Should niacinamide be used in the morning or at night?
Should niacinamide be used every day?
Niacinamide can be used morning and night on a daily basis.

It’s compatible with pretty much every other skincare ingredient, so don’t worry about adding it to your skincare stack.
While it has many benefits for your face, it can also be used on the neck, chest, and back, particularly if you’re investing due to the acne-fighting benefits.

WHAT BENEFITS DOES NIACINAMIDE OFFER?
Overall, niacinamide can help build proteins in the skin and lock in moisture to prevent environmental damage.

INDIVIDUAL BENEFITS OF NIACINAMIDE INCLUDE:
*Immunity.
Niacinamide helps build keratin, a type of protein that keeps your skin firm and healthy.

*Lipid barrier:
Niacinamide can help your skin grow a ceramide (lipid) barrier, which can, in turn, helps retain moisture.
This is beneficial for all skin types, especially if you have eczema or mature skin.

*Minimizes redness and blotchiness:
Niacinamide reduces inflammation, which may help ease redness from eczema, acne, and other inflammatory skin conditions.

*Minimizes pore appearance:
Keeping skin smooth and moisturized may have a secondary benefit — a natural reduction in pore size over time.

*Regulates oil:
The benefits of moisture retention aren’t just for those with dry skin types.
Niacinimide can also help regulate the amount of oil the sebaceous glands produce and prevent your glands from going into overdrive.
Niacinamide protects against sun damage.
Niacinamide can concurrently rebuild healthy skin cells while also protecting them from damage caused by ultraviolet rays.

*Treats hyperpigmentation:
Some research has found that 5 percent niacinamide concentrations can be helpful in lightening dark spots.
Benefits were seen after four weeks, but not beyond two months.
This benefit may be due to increased collagen production.

*Minimizes fine lines and wrinkles:
Research has also found that the same concentration was helpful in reducing some signs of sun damage that come with aging.
This includes fine lines and wrinkles.
Protects against oxidative stress.
Niacinamide helps build cells in the skin while also protecting them from environmental stresses, such as sunlight, pollution, and toxins.

*Treats acne:
Niacinamide may be helpful for severe acne, especially inflammatory forms like papules and pustules.
Over time, you may see fewer lesions and improved skin texture.

DOES THE TYPE OF SKIN CARE PRODUCT MATTER OR WHEN NIACINAMIDE IS USED IN YOUR ROUTINE?
Many niacinamide products come in the form of serums.
Think of serums as extra treatments that address individual skin concerns outside of regular cleansing, toning, and moisturizing.
Your niacinamide serum should be applied after toning but before moisturizing.
Some cleansers and creams also contain niacinamide.
Niacinamide is also found in some face masks, which are rinsed off after each use.

WHAT SHOULD I TOOK FOR WHEN SELECTING A PRODUCT?
Niacinamide concentration can vary across products, though most formulations are 5 percent or less.
Some reports suggest 5 percent formulas are effective in treating hyperpigmentation and damage related to sun exposure.
If you have sensitive skin, you may want to start with a lower concentration. Formulas with 2 percent niacinamide may help ease symptoms of eczema and similar conditions.
Niacinamide may be listed as “niacin” and “nicotinamide” on product labels.

CAN NIACINAMIDE BE COMBINED WITH OTHER SKIN CARE INGREDIENTS FOR MAXIMUM EFFECT?
Niacinamide may be used alongside other active ingredients for optimal results.
For example, some reports suggest that supplemental niacinamide may work well alongside copper, folic acid, and zinc to treat acne.
You may be able to get more out of your niacinamide serum by using it alongside hyaluronic acid.

Hyaluronic acid is said to increase product absorption.
Niacinamide has a plethora of benefits as a skin care ingredient including its ability to:
Minimize the appearance of enlarged pores and improve “orange peel” textured skin

Restore skin’s defenses against moisture loss and dehydration
Visibly even out skin tone and discolorations from sun damage
Among a handful of other amazing skin care ingredients such as retinol and vitamin C, niacinamide is a standout because of its versatility for almost any skin care concern and skin type.

WHAT DOES NIACINAMIDE DO FOR YOUR SKIN?
Niacinamide’s abilities are made possible thanks to its status as a multitasking bio-active ingredient.
However, this powerhouse form of vitamin B takes a bit of a journey before our skin and its supporting surface cells can reap its benefits.
After niacinamide’s applied to skin, it’s broken down into the form of this vitamin that our cells can use, the coenzyme nicotinamide adenine dinucleotide.
Niacinamide’s this coenzyme that’s believed to be responsible for niacinamide’s benefits to skin.

NIACINAMIDE SKIN BENEFITS:
This multitalented ingredient is truly one that all can add to their routine, no matter skin type or skin concern.
Some people’s skin may have more concerns niacinamide can address, but without question everyone’s skin will gain something from this B vitamin.

*Minimizes enlarged pores
Niacinamide is most famous for its ability to reduce the appearance of enlarged pores. 
As we touched on above, research hasn’t determined how this B vitamin works its pore-reducing magic, but it seems that niacinamide has a normalizing ability on the pore lining.

This plays a role in helping to keep oil and debris from getting backed up, which leads to clogs and rough, bumpy skin.
As the clog forms and worsens, the pores stretch to compensate, leading to enlargement.

Routine usage of niacinamide helps pores return to their natural size.
Sun damage can cause pores to become stretched, too, leading to what some describe as "orange peel skin".
Higher concentrations of niacinamide can help visibly tighten pores by shoring up skin’s supportive elements, often dramatically improving orange peel texture.

*Added moisture
Other benefits of niacinamide are that it helps renew and restore skin's surface against moisture loss and dehydration. 
When key fatty acids in skin’s barrier known as ceramides gradually deplete, skin is left vulnerable to all sorts of problems, from persistent patches of dry, flaky skin to increasingly becoming extra-sensitive.

If you struggle with dry skin, topical application of niacinamide has been shown to boost the hydrating ability of moisturizers so skin’s surface can better resist the moisture loss that leads to recurrent dryness and flaky texture.
Niacinamide works brilliantly with common moisturizer ingredients like glycerin, non-fragrant plant oils, cholesterol, sodium PCA, and sodium hyaluronate.

*Brightens skin
How does niacinamide help discolorations and uneven skin tone? 
Both concerns stem from excess melanin (skin pigment) showing on skin’s surface.
In concentrations of 5% and greater, niacinamide works via several pathways to keep new discolorations from appearing.

At the same time, it also helps reduce the appearance of existing discolorations, so your skin tone looks more even.
Research has shown niacinamide and tranexamic acid work particularly well together, and as mentioned above, it can be used with other discoloration-reducing ingredients such as all forms of vitamin C, licorice, retinol, and bakuchiol.

CAN YOU USE NIACINAMIDE WITH RETINOL?
Yes!
In fact, dermatologists say that retinol and niacinamide is a recommended combination for achieving quicker results.
Niacinamide's calming benefits can also combat the negative side effects and irritation that often come alongside retinol's wrinkle-fighting magic.

HOW TO USE NIACINAMIDE:
Niacinamide is compatible with other powerful ingredients like peptides, hyaluronic acid, AHAs, BHA, and all types of antioxidants. 
This multi-ingredient approach to skin care is important because as great as niacinamide is, it’s not the only ingredient skin needs to look and feel its best.
Think of it like your diet—as healthy as kale is, if kale was all you ate, you’d soon become malnourished because your body needs more than one healthy food to maintain itself.
The same is true for skin, the body’s largest (and most exposed) organ.

ADDING NIACINAMIDE IN SKIN CARE ROUTINE:
Using niacinamide is as easy as finding great skin care products that contain it and applying it in order of:
*Cleanser
*Toner
*Exfoliant
*Layer the rest of your skin care serums, treatments, and moisturizers (including those with niacinamide) in order of thinnest to thickest texture
*During the day, finish with a broad-spectrum sunscreen rated SPF 30 or greater

How long does niacinamide take to work?
Generally speaking, you should start to see results after 2-4 weeks of twice daily usage (depending on the severity of your skin concerns and how concentrated your niacinamide product is).
Ongoing use is required for continued improvement and maintaining results.

Results will continue to improve over time but do not expect your skin to be completely “poreless”—that isn’t possible for any skin care product (not to mention, your skin needs its pores for many vital functions).
What you can expect is pores that look smaller, skin tone that looks more even, visibly reduced fine lines and wrinkles, and an overall healthier glow.

RECOMMENDED NIACINAMIDE PRODUCTS:
For best results, use niacinamide products that are meant to be left on skin (such as serums or moisturizers) instead of rinse-off products (like cleansers) where contact time is limited.
Niacinamide toner can be especially beneficial when applied after cleansing to rehydrate and replenish skin.

A concentrated 10% Niacinamide Booster can be used on its own (much like a serum) or mixed into your favorite non-SPF moisturizer, based on personal preference.
Those with stubborn concerns around advanced signs of sun damage, orange peel texture, lax pores, and oil-related bumps should consider trying an advanced strength 20% niacinamide serum.

You can use niacinamide-containing products around your eyes, too.
Some might find applying a moisturizer or niacinamide eye cream helps soften the appearance of crow’s feet and dark circles, not to mention enables this delicate area to retain skin-smoothing moisture and resist loss of firmness.
Facial care products with niacinamide can also be applied to the neck and chest.

For skin concerns beyond the face and neck, a niacinamide body serum can be advantageous.
Niacinamide’s benefits on the body include tackling uneven tone, discolorations (including dotted marks around the hair follicles), plus restoring and strengthening skin’s moisture barrier.
Niacinamide Body Serum targets uneven tone and signs of aging on the body, making it a terrific addition to any post-shower body care routine.

WHAT DOES NIACINAMIDE DO FOR SKIN?
Research shows that niacinamide has the potential to help support a healthy skin barrier.
When applied topically, niacinamide can help reduce moisture loss and skin dehydration.
It may also help calm your skin and has been shown to have antioxidant capabilities.
This makes niacinamide a popular ingredient in formulas aimed at improving visible signs of environmental damage—like premature skin aging and skin discoloration.

WHAT IS NIACINAMIDE GOOD FOR IN SKINCARE PRODUCTS?
Niacinamide can help your skin appear healthier and more radiant when used as part of a consistent skincare routine.
Although it’s most commonly-known for its skin-brightening and hydrating properties, niacinamide’s skin benefits also include its ability to help calm your skin, reduce the appearance of redness, and improve uneven skin texture.
The benefits of niacinamide may be especially helpful for blemish-prone skin and mature skin, since this ingredient can help soothe skin and help minimize the appearance of wrinkles and large pores.

CAN NIACINAMIDE BE USED WITH OTHER SKINCARE INGREDIENTS?
Niacinamide's versatility is often considered to be one of its key benefits.
Not only is it generally compatible with other skincare ingredients, but niacinamide is typically well-tolerated for daily use—even by those with sensitive skin.
This means it can be used by multiple skin types and for a variety of concerns, such as dryness, flakiness, and blotchiness.

CAN ALL SKIN TYPES USE NIACINAMIDE?
Formulas with niacinamide are typically suitable for most skin types, including those with sensitive and blemish-prone skin.
For specific questions about your skin type, consult with a board-certified dermatologist for the best personalized advice.

WHAT TYPES OF SKINCARE PRODUCTS INCLUDE NIACINAMIDE?
Niacinamide is found in a variety of skincare products, including cleansers, lotions, facial toners, and creams.
Always use these products as directed, according to the product label.

CAN NIACINAMIDE BE USED ON BOTH THE FACE AND BODY?
Yes, niacinamide can be found in CeraVe products formulated to hydrate and help calm skin on both your face and body.
When choosing the ideal face or body product for your needs, we recommend looking for niacinamide products that are formulated specifically for your skin type and primary skin concerns.

AT WHAT AGE SHOULD I START USING NIACINAMIDE?
Because it offers a variety of benefits, niacinamide can be used to help target common skin concerns during any stage of life.
Niacinamide can be a helpful addition to an anti-aging skincare routine for mature skin due to its ability to help minimize the appearance of age-related skin concerns like wrinkles and skin discoloration.
Research shows that niacinamide might play an important role in helping your body build keratin, the main structural protein that helps keep skin looking firm and youthful.

HOW TO USE NIACINAMIDE IN YOUR SKINCARE ROUTINE
Reaping the benefits of niacinamide comes down to choosing gentle products that are formulated with dermatologists, fragrance-free, and suitable for your skin type.
It’s important to always apply your skincare products by following the instructions on the label.
Niacinamide can be used daily as part of a well-rounded skincare routine for healthy-looking skin at any age.
For example, to create a simple morning regimen that features niacinamide.

CHEMISTRY OF NIACINAMIDE:
The structure of Niacinamide consists of a pyridine ring to which a primary amide group is attached in the meta position.
Niacinamide is an amide of nicotinic acid.
As an aromatic compound, Niacinamide undergoes electrophilic substitution reactions and transformations of its two functional groups.
Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.

INDUSTRIAL PRODUCTION OF NIACINAMIDE:
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of Niacinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Niacinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014

BIOCHEMISTRY OF NIACINAMIDE:
Niacinamide, as a part of the cofactor Niacinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, Niacinamide is incorporated into NAD+ and Niacinamide adenine dinucleotide phosphate (NADP+).
NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.

If humans ingest Niacinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.
However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of Niacinamide.

NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the Niacinamide.
In NAD+, the nitrogen in the aromatic Niacinamide ring is covalently bonded to adenine dinucleotide.

The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.

BIOLOGICAL ROLE OF NIACINAMIDE:
Niacinamide occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Niacinamide is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Niacinamide can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.

FOOD SOURCES OF NIACINAMIDE:
Niacinamide occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Niacinamide is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Niacinamide is also available in higher doses.

RESEARCH:
A 2015 trial found niacinamide to reduce the rate of new nonmelanoma skin cancers and actinic keratoses in a group of people at high risk for the conditions.
Niacinamide has been investigated for many additional disorders, including treatment of bullous pemphigoid nonmelanoma skin cancers.

Niacinamide may be beneficial in treating psoriasis.
There is tentative evidence for a potential role of niacinamide in treating acne, rosacea, autoimmune blistering disorders, ageing skin, and atopic dermatitis.

Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.
ARCON (accelerated radiotherapy plus carbogen inhalation and Niacinamide) has been studied in cancer.
Research has suggested niacinamide may play a role in the treatment of HIV.

LET'S LOOK AT ALL THOSE SKIN BENEFITS:
#1: Anti-aging, wrinkle-smoothing properties:
With age, our skin tends to slow down in many ways.
One of them is in producing important proteins, such as keratin, filaggrin, and involucrin, at a slower rate.

Reduced amounts of these proteins results in poorer skin structure, reduced skin elasticity, and more wrinkles.
Studies show that niacinamide can boost collagen production as well as the production of these three important proteins.
That means improved skin structure and fewer wrinkles.

FYI, anti-aging studies usually use 4-5% niacinamide daily for 8-12 weeks, so if you are after the anti-aging benefits try to choose a product that tells you the exact percentage of niacinamide it contains.

#2: Skin-lightening properties:
Hyperpigmentation or brown spots are really stubborn and honestly it can be really hard to make them disappear just by topical products.
What you can expect for them is to fade a little and niacinamide is a great ingredient to help with that.
Studies show that 2-5% niacinamide used daily for 8 weeks results in significant lightening of hyperpigmentation.

When combined with amino sugar, acetyl glucosamine the results are even better.
What's more, niacinamide as a skin lightener works in a way different to most others.
It suppresses the transfer of melanosomes (little spheres carrying the melanin pigment) from melanocytes (skin cells producing the melanin) to keratinocytes (skin cells in the top layer of the skin) while most other skin lighteners block an enzyme called tyrosinase (that plays an important role in melanin production).

So if you want to mount a multi-front attack on the brown spots you can combine a niacinamide treatment with tyrosinase inhibitors like vitamin C, arbutin or kojic acid.

#3: Barrier repair functions: the skin barrier is the outer layer of the skin that is amazingly important at keeping the skin hydrated and healthy.
The stuff between the skin cells consists mainly of free fatty acids, cholesterol, and ceramides.
The amount and structure of these determine how healthy the skin barrier is.
What studies have shown is that 2% niacinamide can increase the synthesis of free fatty acids, cholesterol, and ceramides that result in healthier and stronger skin barrier, decreased trans-epidermal water loss and better hydrated skin.

#4: Anti-acne properties:
though niacinamide does not count as one of the gold standard anti-acne ingredients, if you have problem skin it's totally worth a try.
It has sebum regulating and anti-inflammatory properties and a study that used 4% niacinamide for 8 weeks to treat acne found that 82% of those treated showed some improvement.
What's more, the results were slightly better than with a 1% clindamycin gel, an antibiotics often used to treat acne.

#5: Other notable things:
if the above four things are not enough to convince you about niacinamide here are some more reasons! :)
Studies show that vitamin B3 can help to speed up epidermal cell growth (that slows down with age), it can help with wound healing, it can smooth the structure of the skin and it has also antibacterial and photo protective properties.
Plus, it might also be useful for rosacea and atopic dermatitis probably because of its anti-inflammatory property.

WHAT DOES NIACINAMIDE DO?
Niacinamide is a true multitasker.
From boosting hydration to protecting the skin from environmental damage, Niacinamide offers a wide variety of benefits.
Niacinamide penetrates your skin and helps renew your complexion from within.

SKIN BENEFITS OF NIACINAMIDE
Although Niacinamide may be less talked about than the wonder ingredient of the decade, retinol, its benefits are just as significant.
Here are some of the most amazing skin benefits of Niacinamide:
Increases the skin’s ability to maintain hydration.

Niacinamide strengthens your skin’s moisture barrier to improve its ability to hold on to moisture.
Your skin is less likely to dry out and will stay hydrated for longer.
If dry skin is a concern for you, check out our guide on how to tackle dry skin.

*Improves skin texture:
Niacinamide helps reduce the size of your pores while keeping your skin moisturised.

*Rejuvenates the eye area:
The skin around your eye is extremely delicate, and this is where usually the first signs of skin ageing appear.
Niacinamide can help with these skin concerns and reduce the appearance of fine lines and wrinkles for younger-looking eyes.

*Helps with dark spots and hyperpigmentation:
Niacinamide’s is a true multitasker, it can also help lighten dark spots and the marks of hyperpigmentation.

*Aids surface skin cell regeneration for younger-looking skin:
By locking in moisture, Niacinamide provides your skin with the moisture it needs for natural skin cell turnover to take place properly.

*Helps with oily skin:
Niacinamide helps regulate sebum production and this can help control oily skin.

WHAT DOES NIACINAMIDE DO FOR MY SKIN?
Niacinamide is a multipurpose skin care ingredient.
Niacinamide helps build keratin, a protein that maintains skin health.
Niacinamide’s also been shown to make your skin stronger, smoother and brighter.
“Niacinamide is used to treat acne and can help nourish and protect your skin, especially when it’s used with other products like retinol.
Niacinamide’s a potent nutrient that rarely has side effects.”

HERE ARE THE TOP SIX NIACINAMIDE BENEFITS:
1. Boost hydration
Niacinamide may enhance the function of your skin’s lipid barrier (a layer of water and oil that protects your skin).
This helps lock moisture in and keep pollutants or other potential irritants out, making your skin more hydrated and less sensitive.

2. Calm redness
Niacinamide has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema.
Niacinamide can also soothe irritation caused by strong exfoliants like retinol or glycolic acid that remove dead cells from the surface of your skin.

3. May reduce the appearance of pores
Nothing has been proven to reduce the actual size of your pores.
But niacinamide may help minimize their appearance by helping keep your skin smooth and clear.
Niacinamide also may help regulate the amount of oil your glands produce, which can prevent breakouts and clogged pores.

4. Possibly protect against skin cancer
Niacinamide is a close relative of another B vitamin called nicotinamide.
Oral Niacinamide supplements may help prevent new skin cancer or precancerous spots from developing in some people.
But more studies are needed to confirm this benefit.

A recent study also shows nicotinamide, the cousin of niacinamide, may increase the risk of triple-negative breast cancer in those who take the dietary supplement in high levels.
But using niacinamide in a skin care product and applying it topically is generally regarded as safe.

5. Treat dark spots:
Niacinamide is dermatologist-approved for brightening skin tone.
Some research suggests skin care formulas with 5% niacinamide can also help lighten dark spots.
In one small study, a combination of skin brighteners including retinol and niacinamide reduced dark spots and fine lines.
They also improved skin radiance and texture.

6. Reduce wrinkles and fine lines:
This vitamin’s antioxidant properties may help protect your skin and aid its recovery from damage due to factors like aging, sun and stress.
Some research has shown topical niacinamide can improve fine lines and wrinkles, as well as skin sallowness.

HOW DO I USE NIACINAMIDE IN MY SKIN CARE ROUTINE?
Niacinamide can be used once or twice daily after gentle cleansing during your regular skin care routine.
To maximize its benefits, apply niacinamide after applying a moisturizer.
You can also combine niacinamide serum with your moisturizer and apply them together to your face and neck.
Or try a face mask that contains niacinamide for skin recovery and relaxation.

HOW MUCH TO USE NIACINAMIDE:
Most skin care products contain 5% niacinamide or less, but amounts can vary.
Start slowly with a low concentration if you have sensitive skin.
And talk to your healthcare provider if you have any questions or concerns about how to use it or potential side effects.

PAIR NIACINAMIDE WITH OTHER PRODUCTS IN YOUR ROUTINE:
It’s often helpful to pair niacinamide with other skin care products to maximize its benefits.
These include anti-aging formulas with antioxidant vitamin C or moisturizers with ceramides (fat molecules), as well as:
*Glycolic acid.
*Hyaluronic acid.
*Retinol.
*Supplements, such as copper, folic acid and zinc.

HOW DOES NIACINAMIDE WORK IN SKIN?
Let the multi-tasking begin.
Niacinamide not only locks in moisture to support skin’s barrier, it also works to bring dull-looking skin back to life (read: brightens and revives).
Combined with our plant science and high-performing formulas, you get a multi-tasking essential for noticeably healthier-looking skin.

FUNCTIONS AND APPLICATIONS OF NIACINAMIDE:
1.The proper digestion and absorption of protein and fat;
2. To help in the essential amion acid tryptophan is converted to nicotinic acid;
3. To prevent all kinds of nerves, skin diseases;
4. Alleviate vomiting;
5. Promote the nucleic acid Synthesis, to prevent the aging of tissues and organs;
6. Lower the result of taking antidepressants caused by dry mouth and dysuria
7. Slow night muscle spasms, cramps paralysis and other symptoms of hand,foot and neuritis;
8. Is the natural the diuretic.
9. Treatment of congenital hypofunction of metabolism.

QUICK FACTS OF NIACINAMIDE:
A multi-functional skincare superstar with several proven benefits for the skin
Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis

HOW DOES NIACINAMIDE WORK?
If you’re wondering how niacinamide works on skin, then don’t look any further.
Niacinamide is a water-soluble vitamin, which means that it’s not naturally stored in the body.
Because of this, you’ll need to supplement your diet and the skincare you use.

When applied topically, niacinamide sinks into the skin to help reduce inflammation, shrink pores, and even skin tone and texture.
Can niacinamide be used with vitamin C or other ingredients?
The answer is, yes.
Niacinamide can be used with any other skincare ingredient and is often included in most formulas, thanks to the impressive roster of benefits it offers.

WHY SHOULD I USE NIACINAMIDE?
And here are some of those benefits.
Who needs niacinamide?
Put simply, anyone and everyone could benefit from adding niacinamide to their skincare routine.
Niacinamide helps to reduce acne, refine texture, reduce the size of pores, calm rosacea, enhance barrier function, smooth out pigmentation, reduce signs of ageing, and the list goes on.

NIACINAMIDE FOR SKIN CARE:
Niacinamide has been studied for several different skin issues.
*Acne treatment:
Researchers believe that niacinamide's anti-inflammatory effects can reduce the redness and inflammation caused by acne.

According to a review, topical (on the skin) niacinamide reduced acne.
The review also found that oral (by mouth) niacinamide and other supplements treated acne.
However, conclusions about using oral niacinamide alone for acne cannot be made.

*Aging skin:
According to a review, niacinamide increased keratin, an essential protein for healthy skin, in cell cultures.
Niacinamide may also help with other aspects of skincare, such as wrinkles and other signs of aging skin, using topical (skin) products.

*Melasma:
A skin condition that causes hyperpigmentation, or dark spots, melasma often occurs on unprotected skin regularly exposed to the sun.
According to a study, topical (skin) niacinamide cream reduced the appearance of dark spots in people with melasma.

*Skin cancer prevention:
In a randomized controlled trial, 12 months of treatment with 500 milligrams (mg) of niacinamide by mouth twice daily reduced the risk of developing new non-melanoma skin cancers, new squamous-cell carcinomas (skin cancer), and actinic keratosis (i.e., pre-skin cancer).

More high-quality studies are needed before using niacinamide for these conditions.
Always consult a healthcare provider specializing in skin health, such as a dermatologist, if you have developed a skin issue.
Self-treating with supplements or delaying diagnosis and treatment can make conditions worse.

WHAT DOES NIACINAMIDE DO FOR YOUR SKIN?
How you use niacinamide largely comes down to which skincare concerns you're looking to target.
Acne, rosacea and sensitivity:
Niacinamide’s anti-inflammatory properties make it an attractive option for those who suffer from rosacea and sensitivity – both the type that you’re born with, as well as temporary post-product irritation that manifests as redness and stinging.

If niacinamide is involved in most important cell functions, then there’s nothing it can’t cure, right?
Well, no—if every cellular process in our bodies could be perfected with vitamin supplements, we wouldn’t need antibiotics or radiation therapy.
That said, oral and topical niacinamide may have some actual benefits for skin health:

*Skin cancer prevention:
Ask a dermatologist what niacinamide does best, and the very first niacinamide benefit they’ll list is probably “skin cancer prevention.”
In a 2015 study in the New England Journal of Medicine, researchers gave 386 patients 500 mg of oral niacinamide or a placebo twice daily for a whole year.

All of the participants had at least two non-melanoma skin cancers within the previous five years and, therefore, were at a high risk for developing another skin cancer.
Results showed that during the study, there were 23% fewer new cases of skin cancer in the group that received niacinamide (336 cancers) compared to those who got the placebo (463 cancers).

NIACINAMIDE BENEFITS ON THE OTHER HAND?
Not so ordinary:
They include potentially improving all kinds of skin concerns, from acne to hyperpigmentation to signs of aging.
You might see niacinamide pop up in a topical product and in supplement form (we’ll explain the differences between the two and any potential side effects below) and wonder which one to choose.
If you aren’t quite sure what niacinamide is or what it’s doing in your moisturizer, you’re not alone.
Here’s what you should know about niacinamide benefits—and how to use niacinamide—before adding it to your skin-care routine.

PHYSICAL and CHEMICAL PROPERTIES of NIACINAMIDE:
CAS Number: 98-92-0
Molecular Weight: 122.12
Beilstein: 383619
EC Number: 202-713-4
MDL number: MFCD00006395
Physical state: crystalline
Color: white
Odor: odorless
Melting point/freezing point:
Melting point/range: 128 - 131 °C - lit.
Initial boiling point and boiling range: 150 - 160 °C at 0,0007 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 150 °C - closed cup
Autoignition temperature: not auto-flammable
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 500 g/l at 25 °C
Partition coefficient: n-octanol/water:
log Pow: -0,38 at 21 °C - Bioaccumulation is not expected.
Vapor pressure: No data available
Density: 1,40 g/cm3 at 25 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available

FIRST AID MEASURES of NIACINAMIDE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of NIACINAMIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of NIACINAMIDE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
- Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of NIACINAMIDE:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of NIACINAMIDE:
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed.
Dry.

STABILITY and REACTIVITY of NIACINAMIDE:
-Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .

SYNONYMS:
Niacinamide
Nicotinic acid amide
Pyridine-3-carboxylic acid amide
Vitamin B3
Vitamin PP
Pyridine-3-carboxylic acid amide
Nicotinic acid amide
Vitamin PP
Vitamin B3
Niacinamide

NICOTILAMIDE; NICOTINAMIDE; NIACINAMIDE, N° CAS : 98-92-0; Nom INCI : NIACINAMIDE. Nom chimique : 3-Pyridinecarboxamide. N° EINECS/ELINCS : 202-713-4. Ses fonctions (INCI) : Agent lissant : Diminue la rugosité ou les irrégularités pour rendre la peau uniforme. Noms français : 3-PYRIDINECARBOXAMIDE; ACETAMIDO-3 PYRIDINE; BETA-PYRIDINECARBOXAMIDE; CARBOXAMIDE-3 PYRIDINE; Niacinamide; NICOTILAMIDE; NICOTINAMIDE; VITAMINE PP. Noms anglais : 3-CARBAMOYLPYRIDINE; 3-PYRIDINECARBOXYLIC ACID AMIDE; NIACIN AMIDE; Niacinamide; NICOTINE ACID AMIDE; NICOTINE AMIDE; NICOTINIC ACID AMIDE; NICOTINIC AMIDE; PYRIDINE-3-CARBOXYLIC ACID AMIDE. Utilisation et sources d'émission: Vitamine (complexe b). 200-659-6 [EINECS]; 202-713-4 [EINECS]; 383619 [Beilstein]; 3-Pyridinecarboxamide [ACD/Index Name]; 98-92-0 [RN]; Dipigyl; MFCD00006395 [MDL number]; Niacinamide [USP] ;Nicotinamid [German] [ACD/IUPAC Name]; nicotinamida [Spanish]; Nicotinamide [ACD/IUPAC Name] [Wiki]; Nicotinamide [French] [ACD/IUPAC Name]; Nicotinamidum [Latin] ;Nicotinic acid amide; Pyridine-3-carboxamide; PYRIDINE-3-CARBOXYLIC ACID AMIDE; T6NJ CVZ [WLN]; Vi-noctyl; Vitamin B3; Vitamin- B3; Vitamin PP; Witamina PP; никотинамид [Russian] ; نيكوتيناميد [Arabic]; 烟酰胺 [Chinese]; 3-(Aminocarbonyl)pyridine; 3-Amidopyridine; 3-Carbamoylpyridine; 3-PYRIDINECARBOXYLIC ACID AMIDE; 6-Aminonicotinamide [ACD/IUPAC Name] Amid kyseliny nikotinove [Czech]; Aminicotin; Amixicotyn; Amnicotin; Austrovit PP; Benicot; b-Pyridinecarboxamide; Delonin amide; Dipegyl; endibion; Endobion; Enduramide; Factor; Factor pp ;Hansamid; Inovitan PP; m-(Aminocarbonyl)pyridine; Mediatric; meilun; NAM; Nandervit-N; NAP; NCA; Niacevit; Niacin amide; Niacotinamide; Niamide; Niavit PP; Nicamide; Nicamina; Nicamindon ; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosan 2; Nicosylamide; Nicota ; Nicotamide; Nicotilamide; Nicotililamido; Nicotine acid amide; nicotine amide; Nicotinic amide;Nicotinsaureamid [German]; Nicotol;Nicotylamide; Nicotylamidum; Nicovel; Nicovit; Nicovitina; nicovitinia; Nicovitol; Nicozymin; Niko-Tamin; Nikotinamid; Nikotinsaeureamid [German]; Niocinamide; Niozymin ; Papulex; Pelmin; Pelmine; Pelonin amide; PP-Faktor; ppHansamid; Propamine A; Pyridine, 3-carbamoyl-; pyridine-3-carboximidic acid; Savacotyl; VI-Nicotyl; vi-nivotyl; Vitamin B; Vitamin B3 amide; β-pyridinecarboxamide

Niacinamide (vitamin B3), also known as nicotinamide, is a form of vitamin B3 (niacin).
Its chemical formula is C6H6N2O, and it is a water-soluble compound.
Niacinamide (vitamin B3) is an essential nutrient that plays a crucial role in various biological processes in the human body.

CAS Number: 98-92-0
EC Number: 202-713-4

APPLICATIONS

Niacinamide (vitamin B3) is commonly used in dietary supplements to address vitamin B3 deficiencies and support overall health.
In the form of oral supplements, it can help improve skin health and alleviate certain dermatological conditions.
Niacinamide (vitamin B3) plays a crucial role in energy production and metabolic processes in the body.

Niacinamide (vitamin B3) is essential for the synthesis of coenzymes that aid in various biochemical reactions.
Niacinamide (vitamin B3) is used in skincare products for its wide range of benefits on the skin.

Niacinamide (vitamin B3) is known to improve the skin's moisture barrier, helping it retain water and stay hydrated.
Niacinamide (vitamin B3) can reduce the appearance of fine lines and wrinkles, making it a popular anti-aging ingredient.

Niacinamide (vitamin B3) is effective in addressing hyperpigmentation and uneven skin tone.
Niacinamide helps regulate sebum production, making it suitable for individuals with oily skin.

Niacinamide (vitamin B3) is used in sunscreen products to provide added UV protection and combat sun damage.
Niacinamide (vitamin B3) is a versatile ingredient in cosmetics and skincare formulations.
Niacinamide is recognized for its soothing effect on sensitive and irritated skin.

Niacinamide (vitamin B3) can minimize redness and inflammation associated with skin conditions like acne and rosacea.
Niacinamide (vitamin B3) can improve the overall texture and appearance of the skin, leading to a more even complexion.
Niacinamide (vitamin B3) is included in various topical formulations, including serums, creams, and lotions.

Its non-comedogenic properties make it suitable for individuals with acne-prone skin.
Niacinamide (vitamin B3) is often used in products targeting dry and dehydrated skin due to its hydrating effects.
Niacinamide (vitamin B3) can enhance the efficacy of other skincare ingredients when used in combination.
Niacinamide (vitamin B3) is known to reduce transepidermal water loss, helping maintain skin moisture.

Niacinamide (vitamin B3) is used in formulations to help combat environmental damage and pollution.
Niacinamide (vitamin B3) can support the repair of the skin's natural moisture barrier, particularly in individuals with compromised skin.
Niacinamide (vitamin B3)'s safety profile and versatility have led to its widespread use in the beauty industry.

In pharmaceuticals, Niacinamide may be included in certain medications and treatments for skin disorders.
Niacinamide (vitamin B3) is also used in some medical and therapeutic applications, such as wound care.
In summary, Niacinamide (vitamin B3) has a wide range of applications, from skincare and cosmetics to dietary supplements and pharmaceuticals, making it a versatile and beneficial compound in various industries.

Niacinamide (vitamin B3) is frequently used in the formulation of anti-aging skincare products due to its ability to reduce the appearance of wrinkles and fine lines.
Niacinamide (vitamin B3) is a versatile ingredient in moisturizers, helping to lock in hydration and prevent water loss from the skin.

In cosmetics, Niacinamide is used to create products that offer a smooth and even complexion.
Niacinamide (vitamin B3) is known to improve the appearance of enlarged pores and refine skin texture.

Niacinamide (vitamin B3) can be found in serums and lotions designed to brighten the skin and fade dark spots and pigmentation.
Niacinamide's soothing properties make it an effective ingredient in products for sensitive or redness-prone skin.

In dermatology, Niacinamide is used as a topical treatment for conditions like eczema and psoriasis.
Niacinamide (vitamin B3) can aid in the management of inflammatory skin conditions and provide relief from itching and discomfort.

Niacinamide (vitamin B3) is used in skincare routines to protect the skin from oxidative stress and free radical damage.
Niacinamide (vitamin B3) has anti-inflammatory properties that make it valuable for addressing conditions like acne and rosacea.
In the pharmaceutical industry, Niacinamide may be included in medications for hyperlipidemia and cardiovascular health.

Niacinamide (vitamin B3)'s role in cholesterol regulation contributes to its use in heart health supplements.
Niacinamide (vitamin B3) can be added to oral supplements to support overall health and well-being.
Niacinamide (vitamin B3) is used as a stable source of vitamin B3 in fortified foods and beverages.

In the food industry, it is used as a food additive and nutrient fortifier.
Niacinamide (vitamin B3) is employed in the manufacture of some hair care products to improve hair health and texture.
Niacinamide (vitamin B3) can be found in shampoos and conditioners designed to strengthen and nourish the hair.

Niacinamide's skin-barrier-supporting properties make it valuable in products for dry and dehydrated skin.
Niacinamide (vitamin B3) is sometimes included in after-sun products to soothe and repair sun-damaged skin.

In wound care, Niacinamide may be used to support the healing of minor cuts and burns.
Niacinamide (vitamin B3) is a key ingredient in some anti-itch creams and ointments for relieving skin discomfort.
Niacinamide (vitamin B3) is used in topical preparations for reducing inflammation and redness from insect bites and stings.

In veterinary medicine, Niacinamide can be included in pet supplements and products to support animal health.
Niacinamide (vitamin B3) is employed in certain industrial applications, such as corrosion inhibitors and coatings.
Niacinamide (vitamin B3) is known for its multifaceted benefits, making it a valuable ingredient in a wide range of products, from skincare and cosmetics to pharmaceuticals and beyond.
Niacinamide (vitamin B3) is an essential nutrient for the human body, participating in a variety of metabolic processes.

As a water-soluble vitamin, it cannot be stored in the body for long periods, so regular dietary intake is necessary.
Niacinamide (vitamin B3) is found naturally in foods like meat, fish, poultry, and enriched cereals.

Niacinamide (vitamin B3) is used in dietary supplements to address vitamin B3 deficiencies, which can lead to conditions like pellagra.
Niacinamide (vitamin B3) is crucial for the conversion of food into energy, supporting normal growth and development.
Niacinamide (vitamin B3) helps maintain the health of the skin, digestive system, and nervous system.

In the pharmaceutical industry, Niacinamide is used in the formulation of various medications and supplements.
Niacinamide (vitamin B3) is included in over-the-counter (OTC) products for its potential to support cardiovascular health.
Niacinamide (vitamin B3) may be part of treatments for high cholesterol and triglyceride levels.

In skincare, Niacinamide is included in a wide range of products, from cleansers to serums.
Niacinamide (vitamin B3) is used in products for individuals with sensitive skin, as it is less likely to cause irritation.
Niacinamide (vitamin B3)'s anti-inflammatory properties can help calm redness and soothe irritated skin.
Niacinamide (vitamin B3) is often incorporated into moisturizers, providing hydration without feeling heavy or greasy.

Niacinamide (vitamin B3) is known to improve the skin's barrier function, reducing water loss and strengthening the skin's defenses.
In cosmetics, it is found in foundations and concealers that offer a natural and radiant finish.
Niacinamide (vitamin B3) can be used in haircare products like conditioners to enhance hair health and shine.

In sunscreens, Niacinamide (vitamin B3) helps protect the skin from UV damage, making it a valuable addition to daily skincare routines.
Niacinamide (vitamin B3) is used in products targeting hyperpigmentation to even out skin tone and fade dark spots.
Niacinamide (vitamin B3) is included in products for individuals with oily skin to help control excess sebum production.

Niacinamide (vitamin B3) is employed in formulations designed to address the appearance of large pores and uneven texture.
Niacinamide (vitamin B3) is suitable for anti-aging products, aiding in the reduction of fine lines and wrinkles.
Niacinamide (vitamin B3) is often recommended by dermatologists to manage acne and minimize breakouts.

In cosmetics, Niacinamide can provide a soothing effect for individuals with skin conditions like rosacea.
Niacinamide (vitamin B3) is compatible with other skincare ingredients and can enhance their effectiveness.
Niacinamide (vitamin B3)'s versatility and safety profile have made it a popular and effective ingredient in both dietary supplements and a wide range of skincare and cosmetic products.
Niacinamide (vitamin B3) is an important cofactor in many enzymatic reactions within the body.
Niacinamide (vitamin B3) is necessary for the metabolism of carbohydrates, fats, and proteins.

In dietary supplements, it can be found in various forms, such as capsules, tablets, and liquid preparations.
Niacinamide (vitamin B3) supplements are often recommended for individuals with dietary deficiencies or specific health concerns.
Niacinamide (vitamin B3) plays a role in maintaining the proper function of the digestive system, including the production of stomach acid.
Niacinamide (vitamin B3)'s anti-inflammatory properties make it useful for addressing digestive conditions like gastritis.

In some pharmaceutical applications, Niacinamide is used in the treatment of diarrhea.
Niacinamide (vitamin B3) can help support healthy nerve function and reduce symptoms of nerve-related conditions.

Niacinamide (vitamin B3) is sometimes recommended for individuals with circulation issues to improve blood flow.
Niacinamide (vitamin B3) can assist in managing blood sugar levels, making it valuable for those with diabetes.
Niacinamide (vitamin B3) is used in eye drops and ophthalmic preparations to reduce intraocular pressure.

In veterinary medicine, it may be included in pet supplements to promote overall health.
Niacinamide (vitamin B3) is employed in agricultural and horticultural applications, as it can enhance plant growth and yield.

Niacinamide (vitamin B3) is used as a plant nutrient, either in its pure form or as a component of fertilizers.
Niacinamide (vitamin B3) can help improve the quality of crops and enhance their resistance to stressors.

In industrial settings, Niacinamide is used as a corrosion inhibitor to protect metals from rust and deterioration.
Niacinamide (vitamin B3) is an important ingredient in the manufacturing of coatings and paints.
Niacinamide (vitamin B3) is used in the production of inks for various applications, including printing and writing.

In the field of textiles, it can be found in dyeing and printing processes.
Niacinamide (vitamin B3)'s stability and compatibility make it suitable for use in a variety of chemical reactions.

In the cosmetic industry, it is used in the formulation of makeup products like foundations and powders.
Niacinamide (vitamin B3) is a key ingredient in haircare products to improve the health and appearance of hair.
Niacinamide (vitamin B3) can be found in some deodorants and antiperspirants for its skin-soothing properties.
Niacinamide (vitamin B3) is included in some topical medications for the treatment of inflammatory skin conditions.

DESCRIPTION

Niacinamide (vitamin B3), also known as nicotinamide, is a form of vitamin B3 (niacin).
Its chemical formula is C6H6N2O, and it is a water-soluble compound.
Niacinamide (vitamin B3) is an essential nutrient that plays a crucial role in various biological processes in the human body.

Niacinamide (vitamin B3) is often used in dietary supplements, skincare products, and medications.
In dietary supplements, Niacinamide (vitamin B3) is used to address niacin (vitamin B3) deficiencies and support overall health.
In skincare, niacinamide is popular for its beneficial effects on the skin, such as improving the skin barrier, reducing inflammation, and addressing issues like acne, hyperpigmentation, and fine lines.
Additionally, Niacinamide (vitamin B3) is sometimes used in pharmaceuticals and cosmetics for its therapeutic and cosmetic properties.

Niacinamide, also known as vitamin B3, is an essential nutrient for human health.
Niacinamide (vitamin B3) is one of the water-soluble B vitamins, along with other B-complex vitamins.

Niacinamide (vitamin B3) plays a vital role in various metabolic processes in the human body.
Niacinamide (vitamin B3) is involved in the synthesis of coenzymes that participate in energy production.
Niacinamide (vitamin B3) is crucial for DNA repair and maintenance.

Niacinamide (vitamin B3) is important for maintaining the health of the skin, nerves, and digestive system.
Niacinamide (vitamin B3) is found naturally in many foods, including meat, fish, and dairy products.
Niacinamide (vitamin B3) is often used to address vitamin B3 deficiencies in dietary supplements.

As a supplement, it can help support overall health and well-being.
In skincare, Niacinamide is recognized for its various beneficial effects on the skin.
Niacinamide (vitamin B3) is known for its anti-inflammatory properties, making it useful for addressing skin redness and irritation.
Niacinamide (vitamin B3) can improve the skin's moisture barrier, helping to retain moisture.

Niacinamide (vitamin B3) is effective in reducing the appearance of fine lines and wrinkles in cosmetics.
Niacinamide (vitamin B3) is used in skincare to address hyperpigmentation and uneven skin tone.
Niacinamide (vitamin B3) can help regulate sebum production, making it beneficial for individuals with oily skin.

Niacinamide (vitamin B3) is often included in sunscreen products for added UV protection.
Niacinamide (vitamin B3) is generally well-tolerated and suitable for a wide range of skin types.

Niacinamide (vitamin B3) is non-comedogenic, meaning it won't clog pores, making it suitable for acne-prone skin.
Niacinamide (vitamin B3) is known to have a soothing effect on sensitive and irritated skin.
Niacinamide (vitamin B3) can improve the overall texture and appearance of the skin with regular use.
Niacinamide (vitamin B3) is often used in cosmetic and skincare products in various concentrations.

Niacinamide (vitamin B3)'s stability and compatibility make it a versatile ingredient in the beauty industry.
Niacinamide (vitamin B3) is recognized for its role in promoting a healthy and radiant complexion.

Niacinamide (vitamin B3) supplements should be taken as directed, and excessive intake can lead to side effects.
In summary, Niacinamide (vitamin B3) is a versatile compound with important roles in nutrition, skincare, and overall health.

PROPERTIES

Physical Properties:

Chemical Formula: C6H6N2O
Molecular Weight: 122.12 g/mol
State: White crystalline powder
Solubility: Soluble in water and alcohol
Odor: Odorless
Taste: Bitter taste
Melting Point: 128-131°C (262-268°F)
Boiling Point: Decomposes at high temperatures
pH: Approximately neutral (pH 6-7)
Density: 1.40 g/cm³

Chemical Properties:

Niacinamide (vitamin B3) is a water-soluble vitamin and a derivative of niacin (nicotinic acid).
Niacinamide (vitamin B3) is stable in acidic and alkaline solutions, making it suitable for various formulations.
Niacinamide (vitamin B3) is not sensitive to light and heat, which contributes to its stability in cosmetic and pharmaceutical products.
Niacinamide (vitamin B3) is non-comedogenic, meaning it does not clog pores, making it suitable for individuals with acne-prone skin.
Niacinamide (vitamin B3) is well-tolerated and generally safe for topical and oral use.
Niacinamide (vitamin B3) can exist in various forms, such as capsules, tablets, creams, and serums.
Niacinamide's chemical structure includes an amide bond, making it a stable and non-acidic form of vitamin B3.

FIRST AID

Inhalation:

If Niacinamide dust or powder is inhaled and respiratory distress occurs, move the affected person to an area with fresh air.
Encourage the individual to breathe slowly and deeply.
If breathing difficulties persist, seek immediate medical attention.

Skin Contact:

In case of skin contact with Niacinamide, immediately remove contaminated clothing and shoes.
Rinse the affected area with plenty of lukewarm running water for at least 15 minutes.
Use mild soap if available to help remove Niacinamide from the skin.
Seek medical attention if skin irritation, redness, or signs of an allergic reaction (such as rash or hives) occur.

Eye Contact:

If Niacinamide comes into contact with the eyes, immediately rinse the eyes with gentle, lukewarm water for at least 15 minutes.
Hold the eyelids open and away from the eyeballs to ensure thorough irrigation.
Contact lenses should be removed if easily possible.
Seek immediate medical attention, especially if eye irritation, redness, pain, or vision problems persist.

Ingestion:

If Niacinamide is ingested and the person is conscious, do not induce vomiting.
Rinse the mouth with water if the individual is able to swallow and has no difficulty doing so.
Give the person a small amount of water to drink to dilute any remaining Niacinamide in the mouth.
Seek immediate medical attention, and provide information about the ingested amount and any symptoms experienced.

General First Aid Notes:

It's essential to consider individual tolerance and sensitivities when providing first aid. Allergic reactions can occur, even with substances considered safe.
Always use personal protective equipment (PPE) such as gloves and protective eyewear when handling chemicals.
In the event of exposure, provide the affected individual with as much information as possible about the nature of the exposure and the substance involved for medical evaluation and treatment.

HANDLING AND STORAGE

Handling:

Personal Protective Equipment (PPE):
When handling Niacinamide, use appropriate PPE, including safety glasses or goggles, lab coat or protective clothing, and gloves.
Ensure that PPE is clean and in good condition.

Ventilation:
Work in a well-ventilated area to minimize exposure to dust or vapors.
Use local exhaust ventilation if available.

Avoid Skin and Eye Contact:
Prevent skin and eye contact by wearing suitable gloves and protective eyewear.
In case of accidental contact, follow the appropriate first aid measures.

Avoid Ingestion and Inhalation:
Do not eat, drink, smoke, or apply cosmetics in areas where Niacinamide is being handled.
Avoid inhaling Niacinamide dust or vapors.
Use a dust mask or respirator if necessary.

Prevent Contamination:
Do not touch your face, especially your eyes, nose, or mouth, with contaminated hands or gloves.
Use clean tools and equipment to handle Niacinamide to prevent contamination.

Labeling and Storage:
Clearly label containers that hold Niacinamide with appropriate hazard information, chemical name, and handling instructions.
Store Niacinamide away from incompatible materials.

Storage:

Location:
Store Niacinamide in a cool, dry, well-ventilated area.
Keep it away from direct sunlight and heat sources.

Temperature:
Maintain storage temperatures between 20°C and 25°C (68°F to 77°F).
Avoid temperature extremes.

Protection from Moisture:
Keep Niacinamide containers tightly sealed to prevent moisture absorption, as it can cause clumping and reduce the quality of the product.

Separation:
Store Niacinamide away from strong oxidizing agents, strong acids, and incompatible chemicals to avoid potential reactions.

Original Packaging:
Whenever possible, use the original, properly labeled packaging for Niacinamide.
This packaging is designed to protect the substance during storage.

Keep Out of Reach of Children:
Store Niacinamide in a location that is not accessible to children or unauthorized personnel.

Fire Precautions:
While Niacinamide is not flammable, take general fire precautions in the storage area and follow local regulations for fire safety.

SYNONYMS

Nicotinamide
Nicotinic acid amide
Nicotinylamide
3-Pyridinecarboxamide
Niacin amide
Vitamin PP
Nicomide
Nicotylamidum
Amide PP
Nicosan
Nictoamide
Pellagra preventive factor
Vitamin B3 amide
3-Carbamoylpyridine
Pyridine-3-carboxamide
Niacinamide riboside
Nicotinoyl amide
Nicotinyl amide
Nicotinylamide
Amide vitamin B3
Nicotinic amide
Nicotinic acid amide
Vitamin PP amide
Vitamin B3 (amid)
Niacinamide riboside chloride
3-Pyridineamide
Nicotinamidum
Nicotinic acid amide
Nicotinamid
Amide of Pyridine-3-carboxylic acid
Nicotinamidum
Niacinamid
Nicotinamide ribonucleoside
Amide PP
Nicotinic acid amide
Vitamin B3 amide
Nicotinic acid amide
3-Carbamoylpyridine
Nicotinoyl amide
Nicotinyl amide
3-Carbamoylpyridine
3-Pyridinecarboxylic acid amide
Nicotinoyl amide
Nicotinyl amide
Nicotinic amide
Pyridine-3-carboxamide
Pyridine-3-carboxylic acid amide
Niacinamide riboside chloride
Nicotinamide riboside chloride
Nicotinamide ribonucleoside

SYNONYMS Nickelous Chloride Hexahydrate Nickel(II)Chloride Hexahydrate; Nickel(II) Chloride Hexahydrate; CAS CO. 7791-20-0(Hexahydrate), 13931-83-4, 37211-05-5, 7718-54-9 (Anhydrous)

NICKEL CHLORIDE Nickel chloride Jump to navigationJump to search Nickel chloride Nickel chloride hexahydrate IUPAC name Nickel chloride Other names Infobox references Nickel chloride (or just nickel chloride), is the chemical compound NiCl2. The anhydrous salt is yellow, but the more familiar hydrate NiCl2·6H2O is green. Nickel chloride, in various forms, is the most important source of nickel for chemical synthesis. The nickel chlorides are deliquescent, absorbing moisture from the air to form a solution. Nickel salts have been shown to be carcinogenic to the lungs and nasal passages in cases of long-term inhalation exposure.[4] Contents 1 Production and syntheses 2 Structure of NiCl2 and its hydrates 3 Reactions 3.1 Coordination complexes 3.2 Applications in organic synthesis 3.3 Other uses 4 Safety 5 References 6 External links Production and syntheses The largest scale production of nickel chloride involves the extraction with hydrochloric acid of nickel matte and residues obtained from roasting refining nickel-containing ores. Nickel chloride is not usually prepared in the laboratory because it is inexpensive and has a long shelf-life. Heating the hexahydrate in the range 66-133.°C gives the yellowish dihydrate, NiCl2·2H2O.[5] The hydrates convert to the anhydrous form upon heating in thionyl chloride or by heating under a stream of HCl gas. Simply heating the hydrates does not afford the anhydrous dichloride. The dehydration is accompanied by a color change from green to yellow.[6] In case one needs a pure compound without presence of cobalt, nickel chloride can be obtained cautiously heating hexaamminenickel chloride:[7] Reactions Nickel chloride solutions are acidic, with a pH of around 4 due to the hydrolysis of the Ni2+ ion. Coordination complexes Color of various Ni(II) complexes in aqueous solution. From left to right, [Ni(NH3)6]2+, [Ni(en)3]2+, [NiCl4]2−, [Ni(H2O)6]2+ Most of the reactions ascribed to "nickel chloride" involve the hexahydrate, although specialized reactions require the anhydrous form. Crystals of hexammine nickel chloride Some nickel chloride complexes exist as an equilibrium mixture of two geometries; these examples are some of the most dramatic illustrations of structural isomerism for a given coordination number. For example, NiCl2(PPh3)2, containing four-coordinate Ni(II), exists in solution as a mixture of both the diamagnetic square planar and the paramagnetic tetrahedral isomers. Square planar complexes of nickel can often form five-coordinate adducts. NiCl2 is the precursor to acetylacetonate complexes Ni(acac)2(H2O)2 and the benzene-soluble (Ni(acac)2)3, which is a precursor to Ni(1,5-cyclooctadiene)2, an important reagent in organonickel chemistry. In the presence of water scavengers, hydrated Nickel chloride reacts with dimethoxyethane (dme) to form the molecular complex NiCl2(dme)2.[5] The dme ligands in this complex are labile. For example, this complex reacts with sodium cyclopentadienide to give the sandwich compound nickelocene. Hexammine nickel chloride complex is soluble when respective cobalt complex is not, which allows for easy separating of these close-related metals in laboratory conditions. Application of NiCl2 precatalyst. Other uses Nickel chloride solutions are used for electroplating nickel onto other metal items. Safety Nickel chloride is irritating upon ingestion, inhalation, skin contact, and eye contact. Prolonged inhalation exposure to nickel and its compounds has been linked to increased cancer risk to the lungs and nasal passages.[4] About Nickel chloride High purity Nickel chlorideChloride IonNickel Chloride is an excellent water soluble crystalline Nickel source for uses compatible with chlorides. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Nickel Chloride is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement. Nickel chloride Synonyms Nickel chloride anhydrous, Nickel dichloride, Nickelous chloride, Dichloronickel, Nickel(2+) chloride Nickel chloride (Ni) and water Nickel chloride and water: reaction mechanisms, environmental impact and health effects Seawater contains approximately 0.5-2 ppb of Nickel chloride, and rivers contain approximately 0.3 ppb. Phytoplankton contains 1-10 ppm Nickel chloride (dry mass), resulting in a 103-104 bioconcentration factor compared to seawater. Bentic algae can be found both in freshwater and salt water, and may contain between 0.2 and 84 ppm Nickel chloride. Lobsters contain 0.14-60 ppm Nickel chloride, molluscs 0.1-850 ppm, and fishes between 0.1 and 11 ppm (all values based on a dry mass). Nickel chloride occurs in water as Ni2+ (aq) and sometimes as NiCO3. It may be either dissolved, or complexed with inorganic ligands. Nickel chloride may also be bound to particles. In what way and in what form does Nickel chloride react with water? Under normal conditions Nickel chloride does not react with water. Solubility of Nickel chloride and Nickel chloride compounds Elementary Nickel chloride is water insoluble at T=20oC pressure = 1 bar. However, Nickel chloride compounds may be water soluble. Nickel chloride chloride is most water soluble; 553 g/L at 20oC, to 880 g/L at 99.9oC. Nickel chloride carbonate has a water solubility of 90 mg/L, whereas other Nickel chloride compounds, such as Nickel chloride oxide, Nickel chloride sulphide and Nickel chloride tetra carbonyl are water insoluble. Why is Nickel chloride present in water? Nickel chloride may be found in slate, sandstone, clay minerals and basalt. The main Nickel chloride source is pentlandite. The element accumulates in sediments and is a part of various biological cycles. Nickel chloride may end up in water from both point and non-point sources. Diffuse Nickel chloride emissions may stem from power plants, waste incinerators and metal industries. Nickel chloride is directly emitted from various industries through discharge on surface waters. It is applied in alloys for treatment of heavy metal polluted surface water, in Nickel chloride-cadmium batteries, as a catalyzer and as a pigment. Pure Nickel chloride is often applied as a protective coating on steel and copper objects. Nickel chloride-copper alloys have been applied in coins for a very long time. Other alloys are applied for kitchen ware, jewelry and turbine production. Nickel chloride may be applied as an anti-corrosive. Nickel chloride acetate is applied as a mordant in textile printing, and Nickel chloride carbonate is applied as a catalyzer for fat hardening and for ceramic paint production, as is Nickel chloride chloride. Nickel chloride tetra carbonyl is a by-product of Nickel chloride cleansing and is applied in various production processes. Nickel chloride compounds are also applied in agriculture. Phosphate fertilizers contain traces of Nickel chloride. Nickel chloride is often present in agricultural soils situated near fossil fuel industries. Organic matter often adsorbs Nickel chloride, causing coal and oil to contain traces of the element. Nickel chloride compounds may also be found in sludge, and in slags and fly ashes from waste incinerators. Better waste separation would prove useful, because Nickel chloride is up to 60% recyclable. What are the environmental effects of Nickel chloride in water? Nickel chloride is a dietary requirement for many organisms, but may be toxic in larger doses. Metallic Nickel chloride and some other Nickel chloride compounds are teratogenic and carcinogenic to mammals. Nickel chloride concentrations in plants are usually 1 μg/g, and concentrations above 50 μg/g are toxic. Tea has an extraordinary Nickel chloride content of 7.6 mg/kg dried leaves. Nickel chloride causes growth restraints in algae at concentrations of between 0.5 and 10 ppm. Fishes apparently are less susceptible to Nickel chloride, but this differs between species. For Daphnia hyaline the LD50 for 48 hours is 1.9 ppm. Chronic Nickel chloride toxicity for Daphnia magna lies between 30-150 ppb. The LD50 for marine lobsters lies between 150 and 300 ppm. In the organs of birds mainly living off water organisms Nickel chloride concentrations of 0.6-36 ppm (dry mass) were found. Nickel chloride accumulation in rats mainly occurs in lungs, where concentrations exceed those in other organs by 4-40 times. There are approximately 70 species of plants that accumulate extraordinarily high Nickel chloride concentrations. This may be up to 10,000 ppm (dry mass). For regular plant seed 0.5-2 ppm Nickel chloride in liquid substrates is considered toxic. Most plants have a relatively high Nickel chloride tolerance, but many species of grain are generally more susceptible. When water with a 40 ppm Nickel chloride concentration is added these grains may die. Liming of the soil may rapidly decrease Nickel chloride uptake. On the other hand, high Nickel chloride concentrations may throng other heavy metals. Sludge containing more than 200 ppm Nickel chloride (dry mass) may not be applied to agricultural soils. The five naturally occurring Nickel chloride isotopes are all stable. Eight other isotopes are considered instable. What are the health effects of Nickel chloride in water? The human body contains approximately 10 mg Nickel chloride. Nickel chloride is a dietary requirement for a number of organisms, therefore it might be of significance to humans. The human dietary need is estimated at only 5 μg, which is the result of a 150 μg intake. Nickel chloride probably has a function in urea to ammonia conversion by the urease enzyme. Nickel chloride cannot be resorbed in the digestive gland, unless it is complexed. Nickel chloride inhalation poses a greater risk than Nickel chloride in water. This may cause lung cancer, or nasal tumors. Nickel chloride carcinogenity is probably caused by Nickel chloride replacing zinc and magnesium ions on DNA-polymerase. These observations were mainly made in Nickel chloride working employees. Usually only smoking may cause this problem. Many people develop dermatitis upon skin contact with Nickel chloride. The same goes for Nickel chloride solutions. Nickel chloride allergies are more common among women than among men. Nickel chloride compounds may be toxic in high concentrations, but these are often water insoluble, limiting potential harm. For example, Nickel chloride tetra carbonyl is water insoluble, but is toxic and carcinogenic nevertheless. Upon intake of higher doses of Nickel chloride one usually vomits, resulting in rapid removal from the body. Which water purification technologies can be applied to remove Nickel chloride from water? Nickel chloride may be removed from water by means of active carbon adsorption. Coagulation is another feasible option. Nickel chloride only fully precipitates under certain conditions, namely a pH value of at least 9.5, under which it is fully converted to Nickel chloride hydroxide. Nickel chloride (or just nickel chloride), is the chemical compound NiCl2. The anhydrous salt is yellow, but the more familiar hydrate NiCl2·6H2O is green. Nickel chloride, in various forms, is the most important source of nickel for chemical synthesis. The nickel chlorides are deliquescent, absorbing moisture from the air to form a solution. Nickel salts have been shown to be carcinogenic to the lungs and nasal passages in cases of long-term inhalation exposure.[4] Contents 1 Production and syntheses 2 Structure of NiCl2 and its hydrates 3 Reactions 3.1 Coordination complexes 3.2 Applications in organic synthesis 3.3 Other uses 4 Safety 5 References 6 External links Production and syntheses The largest scale production of nickel chloride involves the extraction with hydrochloric acid of nickel matte and residues obtained from roasting refining nickel-containing ores. Nickel chloride is not usually prepared in the laboratory because it is inexpensive and has a long shelf-life. Heating the hexahydrate in the range 66-133.°C gives the yellowish dihydrate, NiCl2·2H2O.[5] The hydrates convert to the anhydrous form upon heating in thionyl chloride or by heating under a stream of HCl gas. Simply heating the hydrates does not afford the anhydrous dichloride. The dehydration is accompanied by a color change from green to yellow.[6] In case one needs a pure compound without presence of cobalt, nickel chloride can be obtained cautiously heating hexaamminenickel chloride:[7] Reactions Nickel chloride solutions are acidic, with a pH of around 4 due to the hydrolysis of the Ni2+ ion. Coordination complexes Color of various Ni(II) complexes in aqueous solution. From left to right, [Ni(NH3)6]2+, [Ni(en)3]2+, [NiCl4]2−, [Ni(H2O)6]2+ Most of the reactions ascribed to "nickel chloride" involve the hexahydrate, although specialized reactions require the anhydrous form. Crystals of hexammine nickel chloride Some nickel chloride complexes exist as an equilibrium mixture of two geometries; these examples are some of the most dramatic illustrations of structural isomerism for a given coordination number. For example, NiCl2(PPh3)2, containing four-coordinate Ni(II), exists in solution as a mixture of both the diamagnetic square planar and the paramagnetic tetrahedral isomers. Square planar complexes of nickel can often form five-coordinate adducts. NiCl2 is the precursor to acetylacetonate complexes Ni(acac)2(H2O)2 and the benzene-soluble (Ni(acac)2)3, which is a precursor to Ni(1,5-cyclooctadiene)2, an important reagent in organonickel chemistry. In the presence of water scavengers, hydrated Nickel chloride reacts with dimethoxyethane (dme) to form the molecular complex NiCl2(dme)2.[5] The dme ligands in this complex are labile. For example, this complex reacts with sodium cyclopentadienide to give the sandwich compound nickelocene. Hexammine nickel chloride complex is soluble when respective cobalt complex is not, which allows for easy separating of these close-related metals in laboratory conditions. Application of NiCl2 precatalyst. Other uses Nickel chloride solutions are used for electroplating nickel onto other metal items. Safety Nickel chloride is irritating upon ingestion, inhalation, skin contact, and eye contact. Prolonged inhalation exposure to nickel and its compounds has been linked to increased cancer risk to the lungs and nasal passages.[4] About Nickel chloride High purity Nickel chlorideChloride IonNickel Chloride is an excellent water soluble crystalline Nickel source for uses compatible with chlorides. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Nickel Chloride is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement. Nickel chloride Synonyms Nickel chloride anhydrous, Nickel dichloride, Nickelous chloride, Dichloronickel, Nickel(2+) chloride Nickel chloride (Ni) and water Nickel chloride and water: reaction mechanisms, environmental impact and health effects Seawater contains approximately 0.5-2 ppb of Nickel chloride, and rivers contain approximately 0.3 ppb. Phytoplankton contains 1-10 ppm Nickel chloride (dry mass), resulting in a 103-104 bioconcentration factor compared to seawater. Bentic algae can be found both in freshwater and salt water, and may contain between 0.2 and 84 ppm Nickel chloride. Lobsters contain 0.14-60 ppm Nickel chloride, molluscs 0.1-850 ppm, and fishes between 0.1 and 11 ppm (all values based on a dry mass). Nickel chloride occurs in water as Ni2+ (aq) and sometimes as NiCO3. It may be either dissolved, or complexed with inorganic ligands. Nickel chloride may also be bound to particles. In what way and in what form does Nickel chloride react with water? Under normal conditions Nickel chloride does not react with water. Solubility of Nickel chloride and Nickel chloride compounds Elementary Nickel chloride is water insoluble at T=20oC pressure = 1 bar. However, Nickel chloride compounds may be water soluble. Nickel chloride chloride is most water soluble; 553 g/L at 20oC, to 880 g/L at 99.9oC. Nickel chloride carbonate has a water solubility of 90 mg/L, whereas other Nickel chloride compounds, such as Nickel chloride oxide, Nickel chloride sulphide and Nickel chloride tetra carbonyl are water insoluble. Why is Nickel chloride present in water? Nickel chloride may be found in slate, sandstone, clay minerals and basalt. The main Nickel chloride source is pentlandite. The element accumulates in sediments and is a part of various biological cycles. Nickel chloride may end up in water from both point and non-point sources. Diffuse Nickel chloride emissions may stem from power plants, waste incinerators and metal industries. Nickel chloride is directly emitted from various industries through discharge on surface waters. It is applied in alloys for treatment of heavy metal polluted surface water, in Nickel chloride-cadmium batteries, as a catalyzer and as a pigment. Pure Nickel chloride is often applied as a protective coating on steel and copper objects. Nickel chloride-copper alloys have been applied in coins for a very long time. Other alloys are applied for kitchen ware, jewelry and turbine production. Nickel chloride may be applied as an anti-corrosive. Nickel chloride acetate is applied as a mordant in textile printing, and Nickel chloride carbonate is applied as a catalyzer for fat hardening and for ceramic paint production, as is Nickel chloride chloride. Nickel chloride tetra carbonyl is a by-product of Nickel chloride cleansing and is applied in various production processes. Nickel chloride compounds are also applied in agriculture. Phosphate fertilizers contain traces of Nickel chloride. Nickel chloride is often present in agricultural soils situated near fossil fuel industries. Organic matter often adsorbs Nickel chloride, causing coal and oil to contain traces of the element. Nickel chloride compounds may also be found in sludge, and in slags and fly ashes from waste incinerators. Better waste separation would prove useful, because Nickel chloride is up to 60% recyclable. What are the environmental effects of Nickel chloride in water? Nickel chloride is a dietary requirement for many organisms, but may be toxic in larger doses. Metallic Nickel chloride and some other Nickel chloride compounds are teratogenic and carcinogenic to mammals. Nickel chloride concentrations in plants are usually 1 μg/g, and concentrations above 50 μg/g are toxic. Tea has an extraordinary Nickel chloride content of 7.6 mg/kg dried leaves. Nickel chloride causes growth restraints in algae at concentrations of between 0.5 and 10 ppm. Fishes apparently are less susceptible to Nickel chloride, but this differs between species. For Daphnia hyaline the LD50 for 48 hours is 1.9 ppm. Chronic Nickel chloride toxicity for Daphnia magna lies between 30-150 ppb. The LD50 for marine lobsters lies between 150 and 300 ppm. In the organs of birds mainly living off water organisms Nickel chloride concentrations of 0.6-36 ppm (dry mass) were found. Nickel chloride accumulation in rats mainly occurs in lungs, where concentrations exceed those in other organs by 4-40 times. There are approximately 70 species of plants that accumulate extraordinarily high Nickel chloride concentrations. This may be up to 10,000 ppm (dry mass). For regular plant seed 0.5-2 ppm Nickel chloride in liquid substrates is considered toxic. Most plants have a relatively high Nickel chloride tolerance, but many species of grain are generally more susceptible. When water with a 40 ppm Nickel chloride concentration is added these grains may die. Liming of the soil may rapidly decrease Nickel chloride uptake. On the other hand, high Nickel chloride concentrations may throng other heavy metals. Sludge containing more than 200 ppm Nickel chloride (dry mass) may not be applied to agricultural soils. The five naturally occurring Nickel chloride isotopes are all stable. Eight other isotopes are considered instable. What are the health effects of Nickel chloride in water? The human body contains approximately 10 mg Nickel chloride. Nickel chloride is a dietary requirement for a number of organisms, therefore it might be of significance to humans. The human dietary need is estimated at only 5 μg, which is the result of a 150 μg intake. Nickel chloride probably has a function in urea to ammonia conversion by the urease enzyme. Nickel chloride cannot be resorbed in the digestive gland, unless it is complexed. Nickel chloride inhalation poses a greater risk than Nickel chloride in water. This may cause lung cancer, or nasal tumors. Nickel chloride carcinogenity is probably caused by Nickel chloride replacing zinc and magnesium ions on DNA-polymerase. These observations were mainly made in Nickel chloride working employees. Usually only smoking may cause this problem. Many people develop dermatitis upon skin contact with Nickel chloride. The same goes for Nickel chloride solutions. Nickel chloride allergies are more common among women than among men. Nickel chloride compounds may be toxic in high concentrations, but these are often water insoluble, limiting potential harm. For example, Nickel chloride tetra carbonyl is water insoluble, but is toxic and carcinogenic nevertheless. Upon intake of higher doses of Nickel chloride one usually vomits, resulting in rapid removal from the body. Which water purification technologies can be applied to remove Nickel chloride from water? Nickel chloride may be removed from water by means of active carbon adsorption. Coagulation is another feasible option. Nickel chloride only fully precipitates under certain conditions, namely a pH value of at least 9.5, under which it is fully converted to Nickel chloride hydroxide.

SYNONYMS Nickel(II)Sulfate Hexahydrate; Nickelous sulfate, 6-hydrate; Sulfuric Acid, Nickel (2+) Salt, Hexahydrate; Nickel Monosulfate Hexahydrate; Blue Salt; Single Nickel Salt; CAS NO. 7786-81-4 (Anhydrous) 10101-97-0 (Hexahydrate)

NICOTINYL ALCOHOL, N° CAS : 100-55-0, 3-PYRIDINEMETHANOL,Nom INCI : NICOTINYL ALCOHOL. Nom chimique : 3-Pyridylmethanol. N° EINECS/ELINCS : 202-864-6. Classification : Alcool. Ses fonctions (INCI). Tonifiant : Produit une sensation de bien-être sur la peau et les cheveux

DESCRIPTION:
Niacinamide or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.
As a supplement, Nicotiamide (Niacinamide) is used by mouth to prevent and treat pellagra (niacin deficiency)
While nicotinic acid (niacin) may be used for this purpose, niacinamide has the benefit of not causing skin flushing.

CAS Number: 98-92-0
European Community (EC) Number: 202-713-4
IUPAC Name: pyridine-3-carboxamide
Molecular Formula: C6H6N2O

Nicotiamide (Niacinamide) is a white powder.
Nicotiamide (Niacinamide) is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a geroprotector.

Nicotiamide (Niacinamide) is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.
An important compound functioning as a component of the coenzyme NAD.
Its primary significance is in the prevention and/or cure of blacktongue and pellagra.

Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

As a cream, Nicotiamide (Niacinamide) is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.
Nicotiamide (Niacinamide) is a water-soluble vitamin.
Nicotiamide (Niacinamide) is the supplement name, while nicotinamide is the scientific name.

Side effects of Nicotiamide (Niacinamide) are minimal.
At high doses, liver problems may occur.
Normal amounts are safe for use during pregnancy.

Niacinamide is in the vitamin B family of medications, specifically the vitamin B3 complex.
Nicotiamide (Niacinamide) is an amide of nicotinic acid.
Foods that contain Nicotiamide (Niacinamide) include yeast, meat, milk, and green vegetables.

Nicotiamide (Niacinamide) was discovered between 1935 and 1937.
Nicotiamide (Niacinamide) is on the World Health Organization's List of Essential Medicines.
Nicotiamide (Niacinamide) is available as a generic medication and over the counter.

Commercially, Nicotiamide (Niacinamide) is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries, grains have niacinamide added to them.

MEDICAL USES OF NICOTIAMIDE (NIACINAMIDE):
Niacin deficiency:
Nicotiamide (Niacinamide) is the preferred treatment for pellagra, caused by niacin deficiency.

Acne:
Nicotiamide (Niacinamide) cream is used as a treatment for acne.
Nicotiamide (Niacinamide) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Nicotiamide (Niacinamide) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.

The application of 2% topical Nicotiamide (Niacinamide) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Niacinamide has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.

Skin cancer:
Nicotiamide (Niacinamide) at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.

CHEMISTRY OF NICOTIAMIDE (NIACINAMIDE):
The structure of Nicotiamide (Niacinamide) consists of a pyridine ring to which a primary amide group is attached in the meta position.
Nicotiamide (Niacinamide) is an amide of nicotinic acid.
As an aromatic compound, it undergoes electrophilic substitution reactions and transformations of its two functional groups.

Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.
NAD+, the oxidized form of NADH, contains the nicotinamide moiety (highlighted in red)

INDUSTRIAL PRODUCTION OF NICOTIAMIDE (NIACINAMIDE):
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of nicotinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Nicotinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014.

BIOCHEMISTRY OF NICOTIAMIDE (NIACINAMIDE):
The active Nicotiamide (Niacinamide) group on the molecule NAD+ undergoes oxidation in many metabolic pathways.
Nicotiamide (Niacinamide), as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, nicotinamide is incorporated into NAD+ and nicotinamide adenine dinucleotide phosphate (NADP+).

NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.
If humans ingest nicotinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.

However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide.
NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the nicotinamide.

In NAD+, the nitrogen in the aromatic nicotinamide ring is covalently bonded to adenine dinucleotide.
The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.

BIOLOGICAL ROLE OF NICOTIAMIDE (NIACINAMIDE):
Nicotiamide (Niacinamide) occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Nicotiamide (Niacinamide) is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Nicotiamide (Niacinamide) can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.

FOOD SOURCES OF NICOTIAMIDE (NIACINAMIDE):
Nicotiamide (Niacinamide) occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Nicotiamide (Niacinamide) is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Nicotiamide (Niacinamide) is also available in higher doses

Niacinamide, also called nicotinamide, is a form of vitamin B3.
Nicotiamide (Niacinamide) is found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

Nicotiamide (Niacinamide) is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Unlike niacin, niacinamide doesn't help treat high cholesterol.

People use niacinamide to prevent vitamin B3 deficiency and related conditions such as pellagra.
Nicotiamide (Niacinamide) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

CHEMICAL AND PHYSICAL DATA OF NICOTIAMIDE (NIACINAMIDE):
Formula, C6H6N2O
Molar mass, 122.127 g•mol−1
Density, 1.40 g/cm3 g/cm3
Melting point, 129.5 °C (265.1 °F)
Boiling point, 334 °C (633 °F)
Molecular Weight
122.12 g/mol
-0.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
122.048012819 g/mol
Monoisotopic Mass
122.048012819 g/mol
Topological Polar Surface Area
56Å²
Heavy Atom Count
9
Formal Charge
0
Complexity
114
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point, 150 - 160 °C (0.0007 hPa)
Density, 1.40 g/cm3 (20 °C)
Flash point, 182 °C
Ignition temperature, 480 °C
Melting Point, 128 - 131 °C (sublimed)
pH value, 6.0 - 7.5 (50 g/l, H₂O, 20 °C)
Bulk density, 360 kg/m3
Solubility, 691 g/l
Assay (perchloric acid titration, calculated on dried substance), 99.0 - 101.0 %
Assay (HPLC, calc. on dried substance), 98.5 - 101.0 %
Identity (IR-spectrum) (Ph Eur), passes test
Identity (IR-spectrum) (USP), passes test
Identity (coloring 1), passes test
Identity (coloring 2), passes test
Identity (UV/VIS-Spectrum), passes test
Appearance, White to almost white, crystalline powder
Appearance of solution (50 g/l; water), Clear, colourless, not more intense in color than reference solution BY₇
pH (50 g/l; water), 6.0 - 7.5
Melting range (lower value), ≥ 128 °C
Melting range (upper value), ≤ 131 °C
Absorption ratio (A 245 nm/A 262 nm), 0.63 - 0.67
Chloride (Cl), ≤ 210 ppm
Sulfate (SO₄), ≤ 190 ppm
Heavy metals (as Pb) (JP), ≤ 30 ppm
As (Arsenic), ≤ 3 ppm
Cu (Copper), ≤ 20 ppm
Pb (Lead), ≤ 2 ppm
Zn (Zinc), ≤ 25 ppm
Residual solvents (ICH Q3C), excluded by production process
Readily carbonisable substance, passes test
Related substances (HPLC) (Major unspecified impurity), ≤ 0.10 %
Related substances (HPLC) (Sum of all impurities), ≤ 0.2 %
Sulfated ash (600 °C), ≤ 0.1 %
Loss on drying (Vacuum; 18 h), ≤ 0.5 %

SAFETY INFORMATION ABOUT NICOTIAMIDE (NIACINAMIDE):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

SYNONYMS OF NICOTIAMIDE (NIACINAMIDE):
3 Pyridinecarboxamide
3-Pyridinecarboxamide
B 3, Vitamin
B3, Vitamin
Enduramide
Jenapharm, Nicotinsäureamid
Niacinamide
Nicobion
Nicotinamide
Nicotinsäureamid Jenapharm
Papulex
Vitamin B 3
Vitamin B3
Vitamin PP
nicotinamide
niacinamide
98-92-0
3-Pyridinecarboxamide
Nicotinic acid amide
pyridine-3-carboxamide
vitamin PP
Aminicotin
Amixicotyn
Papulex
Nicotylamide
Endobion
Hansamid
Nicobion
Nikotinamid
Savacotyl
Benicot
Dipegyl
Pelmine
Nicotinic amide
Delonin amide
Pelonin amide
Austrovit PP
Vi-Nicotyl
Inovitan PP
Amnicotin
Nicamindon
Nicomidol
Nicosylamide
Nicotamide
Nicotilamide
Nicotililamido
Nicovitina
Nicovitol
Nicozymin
Niocinamide
Niacevit
Niamide
Nicamina
Nicasir
Nicofort
Nicogen
Nicotol
Nicovit
Niozymin
Nicota
Niko-tamin
3-Carbamoylpyridine
Nandervit-N
Nicotinamidum
Niavit PP
Nicosan 2
Nicotine amide
Nicotine acid amide
Nikotinsaeureamid
Pyridine-3-carboxylic acid amide
Vitamin B
Nicotylamidum
Nicotinsaureamid
beta-Pyridinecarboxamide
Pyridine, 3-carbamoyl-
Mediatric
Factor pp
m-(Aminocarbonyl)pyridine
3-Pyridinecarboxylic acid amide
Nicotinamida
Pelmin
Acid amide
Witamina PP
PP-Faktor
Amid kyseliny nikotinove
Amide PP
3-(aminocarbonyl)pyridine
Dipigyl
Niacinamid
Nicovel
Vitamin B (VAN)
CCRIS 1901
Nicotinsaureamid [German]
NAM
HSDB 1237
Nikotinsaeureamid [German]
Amid kyseliny nikotinove [Czech]
Nicotinamidum [INN-Latin]
Nicotinamida [INN-Spanish]
AI3-02906
NSC 13128
Nicotinamid
Nictoamide
Nicotinsaeureamid
3-Amidopyridine
Vi-noctyl
EINECS 202-713-4
NSC-13128
NSC-27452
b-Pyridinecarboxamide
Niacinamide (USP)
Niacinamide [USP]
UNII-25X51I8RD4
Nicotinamide [INN]
DTXSID2020929
CHEBI:17154
25X51I8RD4
Nicotinamide (Standard)
NSC13128
MFCD00006395
.beta.-Pyridinecarboxamide
Nicotinamide-(amide-15N)
Nicotinamide (Vitamin B3)
CHEMBL1140
DTXCID00929
MLS000069714
TPN COMPONENT NIACINAMIDE
EC 202-713-4
NIACINAMIDE COMPONENT OF TPN
NSC27452
NCGC00093354-03
NCGC00093354-05
SMR000058212
Nicotinamide 10 microg/mL in Acetonitrile
NIACINAMIDE (II)
NIACINAMIDE [II]
Niacinamide;Nicotinic acid amide;Vitamin B3
WLN: T6NJ CVZ
Nicotinamidum (INN-Latin)
Nicotinamida (INN-Spanish)
NIACINAMIDE (USP-RS)
NIACINAMIDE [USP-RS]
NICOTINAMIDE (MART.)
NICOTINAMIDE [MART.]
3 Pyridinecarboxamide
Niacinamide [USAN]
NICOTINAMIDE (EP IMPURITY)
NICOTINAMIDE [EP IMPURITY]
NIACINAMIDE (USP MONOGRAPH)
NIACINAMIDE [USP MONOGRAPH]
NICOTINAMIDE (EP MONOGRAPH)
NICOTINAMIDE [EP MONOGRAPH]
CAS-98-92-0
SR-01000721872
Niacotinamide
Nicosedine
Nicamid
nicotin-amide
Pahaba Control
Ultra Whitening
CellExosome HR
CellExosome SB
DEA No. 1405
Celonia CM
Ginseng Whitening
Dr. Cellmo
Royal GinsengCream
TOAS Rejuvenation
Nicotinamide,(S)
Vitamin B3 amide
Costem cell 5 N
Royal GinsengLotion
AAPE Skin Ampoule
CellExosome HE HR
Fantastic LightCream
Royal Ginseng Toner
Vita C Bright Serum
Vita C Bright Toner
Niacinamide Face Mask
Royal Ginseng Essence
Ultra Whitening Ample
TANIA PURECREAM
JUVEHEAL W Ampoule
Nicotinamidum (Latin)
BREXTEM S
NI-NICOTYL
Mediatric (Salt/Mix)
niacin - Vitamin B3
Dr. Color Effect Red
1yc5
DPC Aura Booster Mask
Dr Cellinme Mask Sheet
Opera_ID_775
Vita C Bright EyeCream
Miracle Laser Skin Mist
Niacin (as niacinamide)
Pyridine-3-carboxylamide
APLIN SPOT REMOVER
KARATICA I M CURE
NIACINAMIDE [FCC]
NICOTINAMIDE [MI]
TANIA PURE ESSENCE
VITA C BRIGHTCREAM
Pellagra-Preventing Factor
INTOMEDI HR PEPTIDE
NIACINAMIDE [HSDB]
NIACINAMIDE [INCI]
NICOTINAMIDE [JAN]
NYAAM NYAAM Vita Serum
RGO HYDRATION TONER
bmse000281
Miracle Moisturizer Essence
MolMap_000061
APLIN SPOT ALL KILL
MOISTIE PURE ESSENCE
NIACINAMIDE [VANDF]
DPC Whitening Booster Mask
SCHEMBL2926
AAPE Nutrient Facial Toner
Nicotinamide (JP17/INN)
NICOTINAMIDUM [HPUS]
NYAAM NYAAM Peptide Serum
Cellpium double essence toner
AAPE Continuous Renewal Mask
MLS001424246
Primerose Snail Hydro Essence
Shieldlife Whitening Ion Mask
Ultra V AQUA SHINE MASK
Ultra Whitening First Essence
NICOTINAMIDE [WHO-DD]
NICOTINAMIDE [WHO-IP]
by selected hyaluron day serum
Dr Cellinme Skin Care Ampoule
CELLPIUM REAL MASK PACK
Cellpium super richness ampoule
CAVIALL Wrinkle-Free PowerTox
Cellpium premiumEX hybrid toner
Revital Perfecting Dual Ampoule
SCHEMBL6278767
SGCUT00176
Daily Whitening Care Sheet Mask
Edge Cutimal Cat Whitening Mask
SCHEMBL19978192
BDBM27507
CELLBN MILKY TONE-UPCREAM
HY-B0150R
NYAAM NYAAM Skin Reborn Serum
A11HA01
Cellpium premiumEX hybrid essence
NIACINAMIDE [ORANGE BOOK]
BRIGHTUNING PEPTIDE AMPOULE
Nicotinamide, niacin, vitamin B3
HMS2052M21
HMS2090B05
HMS2093H03
HMS2236J03
HMS3370F21
HMS3394M21
HMS3655M20
HMS3713B22
HMS3884A16
Pharmakon1600-01505397
Ala-C Snail Cell Reparing Essence
AROCELL TIME REVERSE K I T
DR. GLODERM TABRX WHITENING
BCP07322
COSMEPURE BRIGHTENING CALMING
HY-B0150
THE SKIN HOUSE Vital BrightCream
THE SKIN HOUSE Vital BrightSerum
to_000073
ARILAC Brightening Mask Sheet Pack
Nicotinamide 1.0 mg/ml in Methanol
Nicotinamide, >=98.5% (HPLC)
Nicotinamide, >=99.5% (HPLC)
Tox21_111202
Tox21_201716
Tox21_302776
NICOTINAMIDUM [WHO-IP LATIN]
NSC759115
s1899
STL163867
THE SKIN HOUSE Vital Bright Toner
SFERANGS VITA C CAPSULEBOOSTER
AKOS005715850
Niveola P.H.c 3d Festival Mask Pack
Skin Project Ya Cooling Celluven Mask
THE SKIN HOUSE Vital BrightEmulsion
Tox21_111202_1
CCG-101149
CS-1968
DB02701
NC00399
NSC-759115
SB74497
Bk Cell 5days Of Secret Snow Whitening
EVECODE THREAD LIFTING MASK PACK
Nicotinamide 100 microg/mL in Methanol
Nicotinamide, >=98% (HPLC), powder
THE SKIN HOUSE Vital Bright Emulsion
THE SKIN HOUSE Vital Bright EyeCream
NCGC00093354-04
NCGC00093354-06
NCGC00093354-09
NCGC00256432-01
NCGC00259265-01
NIACIN (AS NIACINAMIDE) [VANDF]
AS-13845
BN166252
COSMEPURE BRIGHTENING CALMING TONER
DERLADIE HerbalExtract BodySolution MIST
Nicotinamide, puriss., 99.0-101.0%
SY024804
DR. GLODERM TIME TO WHITENING MASK
FRESH MANDARIN AROMATHERAPY MASK27g
Nicotinamide, tested according to Ph.Eur.
SBI-0206826.P001
AN ADC SP INTENSIVE MOISTURE ESSENCE
CS-0694823
Derma Pella Facial Cleanser for Normal Skin
DR.ALTHEA POWER WHITENING GLUTATHIONE
FT-0631517
FT-0672696
FT-0773644
MIZON ENJOY VITAL UP TIME Whitening Mask
N0078
SW197779-3
The Hayan Cherry Blossom Brightening Essence
EN300-15612
Niacinamide, meets USP testing specifications
C00153
D00036
DERMAHAN THE WHITENING MOISTURIZING MASK
Nicotinamide (Niacinamide), analytical standard
AB00373895-13
AB00373895_15
AB00373895_16
Derma Pella Cleanser for Sensitive and Dry Skin
Nicotinamide, Vetec(TM) reagent grade, >=98%
A845925
AC-907/25014114
AROCELL X BELLE J SUPER POWER CELL AMPOULE
J9 ULTRA ADVANCED INTENSIVE SCALP SERUM V2
Q192423
LEBODY LAB RENEWAL DUAL EFFECT PEPTIDE SERUM
Q-201470
SR-01000721872-3
SR-01000721872-4
SR-01000721872-5
LEBODY LAB RENEWAL DUAL EFFECT IDEBENONE SERUM
MUSTUS DAILY HARVEST SQUEEZE TONE UP MASK PACK
PAPA RECIPE BOMBEE BRIGHTENING HONEY MASK PACK
SISEUNDEUSI LUMINANT MASK PACK STEP2(WHITENING)
Z33546463
F2173-0513
Niacinamide;Nicotinic acid amide;Vitamin B3; Vitamin PP
Nicotinamide, British Pharmacopoeia (BP) Reference Standard
A186B02E-6C70-4E54-9739-79398D439AAA
Nicotinamide, European Pharmacopoeia (EP) Reference Standard
Niacinamide, United States Pharmacopeia (USP) Reference Standard
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Niacinamide, Pharmaceutical Secondary Standard; Certified Reference Material
Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture

DESCRIPTION:
Vitamin B3 or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.
As a supplement, Nicotiamide (Vitamin B3) is used by mouth to prevent and treat pellagra (niacin deficiency)
While nicotinic acid (niacin) may be used for this purpose, Vitamin B3 has the benefit of not causing skin flushing.

CAS Number: 98-92-0
European Community (EC) Number: 202-713-4
IUPAC Name: pyridine-3-carboxamide
Molecular Formula: C6H6N2O

Nicotiamide (Vitamin B3) is a white powder.
Nicotiamide (Vitamin B3) is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a geroprotector.

Nicotiamide (Vitamin B3) is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.
An important compound functioning as a component of the coenzyme NAD.
Its primary significance is in the prevention and/or cure of blacktongue and pellagra.

Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

As a cream, Nicotiamide (Vitamin B3) is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.
Nicotiamide (Vitamin B3) is a water-soluble vitamin.
Nicotiamide (Vitamin B3) is the supplement name, while nicotinamide is the scientific name.

Side effects of Nicotiamide (Vitamin B3) are minimal.
At high doses, liver problems may occur.
Normal amounts are safe for use during pregnancy.

Vitamin B3 is in the vitamin B family of medications, specifically the vitamin B3 complex.
Nicotiamide (Vitamin B3) is an amide of nicotinic acid.
Foods that contain Nicotiamide (Vitamin B3) include yeast, meat, milk, and green vegetables.

Nicotiamide (Vitamin B3) was discovered between 1935 and 1937.
Nicotiamide (Vitamin B3) is on the World Health Organization's List of Essential Medicines.
Nicotiamide (Vitamin B3) is available as a generic medication and over the counter.

Commercially, Nicotiamide (Vitamin B3) is made from either nicotinic acid (niacin) or nicotinonitrile.
In some countries, grains have Vitamin B3 added to them.

MEDICAL USES OF NICOTIAMIDE (VITAMIN B3):
Niacin deficiency:
Nicotiamide (Vitamin B3) is the preferred treatment for pellagra, caused by niacin deficiency.

Acne:
Nicotiamide (Vitamin B3) cream is used as a treatment for acne.
Nicotiamide (Vitamin B3) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Nicotiamide (Vitamin B3) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.

The application of 2% topical Nicotiamide (Vitamin B3) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Vitamin B3 has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.

Skin cancer:
Nicotiamide (Vitamin B3) at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.

CHEMISTRY OF NICOTIAMIDE (VITAMIN B3):
The structure of Nicotiamide (Vitamin B3) consists of a pyridine ring to which a primary amide group is attached in the meta position.
Nicotiamide (Vitamin B3) is an amide of nicotinic acid.
As an aromatic compound, it undergoes electrophilic substitution reactions and transformations of its two functional groups.

Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.
NAD+, the oxidized form of NADH, contains the nicotinamide moiety (highlighted in red)

INDUSTRIAL PRODUCTION OF NICOTIAMIDE (VITAMIN B3):
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of nicotinamide for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Nicotinamide can also be made from nicotinic acid. According to Ullmann's Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014.

BIOCHEMISTRY OF NICOTIAMIDE (VITAMIN B3):
The active Nicotiamide (Vitamin B3) group on the molecule NAD+ undergoes oxidation in many metabolic pathways.
Nicotiamide (Vitamin B3), as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, nicotinamide is incorporated into NAD+ and nicotinamide adenine dinucleotide phosphate (NADP+).

NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.
If humans ingest nicotinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.

However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide.
NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell's energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the nicotinamide.

In NAD+, the nitrogen in the aromatic nicotinamide ring is covalently bonded to adenine dinucleotide.
The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability.

This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.

BIOLOGICAL ROLE OF NICOTIAMIDE (VITAMIN B3):
Nicotiamide (Vitamin B3) occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Nicotiamide (Vitamin B3) is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Nicotiamide (Vitamin B3) can be methylated in the liver to biologically active 1-Methylnicotinamide when there's sufficient methyl donors.

FOOD SOURCES OF NICOTIAMIDE (VITAMIN B3):
Nicotiamide (Vitamin B3) occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Nicotiamide (Vitamin B3) is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Nicotiamide (Vitamin B3) is also available in higher doses

Vitamin B3, also called nicotinamide, is a form of vitamin B3.
Nicotiamide (Vitamin B3) is found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.

Nicotiamide (Vitamin B3) is required for the function of fats and sugars in the body and to maintain healthy cells.
Niacin is converted to Vitamin B3 when it is taken in amounts greater than what is needed by the body.
Unlike niacin, Vitamin B3 doesn't help treat high cholesterol.

People use Vitamin B3 to prevent vitamin B3 deficiency and related conditions such as pellagra.
Nicotiamide (Vitamin B3) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.

CHEMICAL AND PHYSICAL DATA OF NICOTIAMIDE (VITAMIN B3):
Formula, C6H6N2O
Molar mass, 122.127 g•mol−1
Density, 1.40 g/cm3 g/cm3
Melting point, 129.5 °C (265.1 °F)
Boiling point, 334 °C (633 °F)
Molecular Weight
122.12 g/mol
-0.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
122.048012819 g/mol
Monoisotopic Mass
122.048012819 g/mol
Topological Polar Surface Area
56Å²
Heavy Atom Count
9
Formal Charge
0
Complexity
114
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Boiling point, 150 - 160 °C (0.0007 hPa)
Density, 1.40 g/cm3 (20 °C)
Flash point, 182 °C
Ignition temperature, 480 °C
Melting Point, 128 - 131 °C (sublimed)
pH value, 6.0 - 7.5 (50 g/l, H₂O, 20 °C)
Bulk density, 360 kg/m3
Solubility, 691 g/l
Assay (perchloric acid titration, calculated on dried substance), 99.0 - 101.0 %
Assay (HPLC, calc. on dried substance), 98.5 - 101.0 %
Identity (IR-spectrum) (Ph Eur), passes test
Identity (IR-spectrum) (USP), passes test
Identity (coloring 1), passes test
Identity (coloring 2), passes test
Identity (UV/VIS-Spectrum), passes test
Appearance, White to almost white, crystalline powder
Appearance of solution (50 g/l; water), Clear, colourless, not more intense in color than reference solution BY₇
pH (50 g/l; water), 6.0 - 7.5
Melting range (lower value), ≥ 128 °C
Melting range (upper value), ≤ 131 °C
Absorption ratio (A 245 nm/A 262 nm), 0.63 - 0.67
Chloride (Cl), ≤ 210 ppm
Sulfate (SO₄), ≤ 190 ppm
Heavy metals (as Pb) (JP), ≤ 30 ppm
As (Arsenic), ≤ 3 ppm
Cu (Copper), ≤ 20 ppm
Pb (Lead), ≤ 2 ppm
Zn (Zinc), ≤ 25 ppm
Residual solvents (ICH Q3C), excluded by production process
Readily carbonisable substance, passes test
Related substances (HPLC) (Major unspecified impurity), ≤ 0.10 %
Related substances (HPLC) (Sum of all impurities), ≤ 0.2 %
Sulfated ash (600 °C), ≤ 0.1 %
Loss on drying (Vacuum; 18 h), ≤ 0.5 %

SAFETY INFORMATION ABOUT NICOTIAMIDE (VITAMIN B3):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

SYNONYMS OF NICOTIAMIDE (VITAMIN B3):
3 Pyridinecarboxamide
3-Pyridinecarboxamide
B 3, Vitamin
B3, Vitamin
Enduramide
Jenapharm, Nicotinsäureamid
Vitamin B3
Nicobion
Nicotinamide
Nicotinsäureamid Jenapharm
Papulex
Vitamin B 3
Vitamin B3
Vitamin PP
nicotinamide
Vitamin B3
98-92-0
3-Pyridinecarboxamide
Nicotinic acid amide
pyridine-3-carboxamide
vitamin PP
Aminicotin
Amixicotyn
Papulex
Nicotylamide
Endobion
Hansamid
Nicobion
Nikotinamid
Savacotyl
Benicot
Dipegyl
Pelmine
Nicotinic amide
Delonin amide
Pelonin amide
Austrovit PP
Vi-Nicotyl
Inovitan PP
Amnicotin
Nicamindon
Nicomidol
Nicosylamide
Nicotamide
Nicotilamide
Nicotililamido
Nicovitina
Nicovitol
Nicozymin
Niocinamide
Niacevit
Niamide
Nicamina
Nicasir
Nicofort
Nicogen
Nicotol
Nicovit
Niozymin
Nicota
Niko-tamin
3-Carbamoylpyridine
Nandervit-N
Nicotinamidum
Niavit PP
Nicosan 2
Nicotine amide
Nicotine acid amide
Nikotinsaeureamid
Pyridine-3-carboxylic acid amide
Vitamin B
Nicotylamidum
Nicotinsaureamid
beta-Pyridinecarboxamide
Pyridine, 3-carbamoyl-
Mediatric
Factor pp
m-(Aminocarbonyl)pyridine
3-Pyridinecarboxylic acid amide
Nicotinamida
Pelmin
Acid amide
Witamina PP
PP-Faktor
Amid kyseliny nikotinove
Amide PP
3-(aminocarbonyl)pyridine
Dipigyl
Niacinamid
Nicovel
Vitamin B (VAN)
CCRIS 1901
Nicotinsaureamid [German]
NAM
HSDB 1237
Nikotinsaeureamid [German]
Amid kyseliny nikotinove [Czech]
Nicotinamidum [INN-Latin]
Nicotinamida [INN-Spanish]
AI3-02906
NSC 13128
Nicotinamid
Nictoamide
Nicotinsaeureamid
3-Amidopyridine
Vi-noctyl
EINECS 202-713-4
NSC-13128
NSC-27452
b-Pyridinecarboxamide
Vitamin B3 (USP)
Vitamin B3 [USP]
UNII-25X51I8RD4
Nicotinamide [INN]
DTXSID2020929
CHEBI:17154
25X51I8RD4
Nicotinamide (Standard)
NSC13128
MFCD00006395
.beta.-Pyridinecarboxamide
Nicotinamide-(amide-15N)
Nicotinamide (Vitamin B3)
CHEMBL1140
DTXCID00929
MLS000069714
TPN COMPONENT VITAMIN B3
EC 202-713-4
VITAMIN B3 COMPONENT OF TPN
NSC27452
NCGC00093354-03
NCGC00093354-05
SMR000058212
Nicotinamide 10 microg/mL in Acetonitrile
VITAMIN B3 (II)
VITAMIN B3 [II]
Vitamin B3;Nicotinic acid amide;Vitamin B3
WLN: T6NJ CVZ
Nicotinamidum (INN-Latin)
Nicotinamida (INN-Spanish)
VITAMIN B3 (USP-RS)
VITAMIN B3 [USP-RS]
NICOTINAMIDE (MART.)
NICOTINAMIDE [MART.]
3 Pyridinecarboxamide
Vitamin B3 [USAN]
NICOTINAMIDE (EP IMPURITY)
NICOTINAMIDE [EP IMPURITY]
VITAMIN B3 (USP MONOGRAPH)
VITAMIN B3 [USP MONOGRAPH]
NICOTINAMIDE (EP MONOGRAPH)
NICOTINAMIDE [EP MONOGRAPH]
CAS-98-92-0
SR-01000721872
Niacotinamide
Nicosedine
Nicamid
nicotin-amide
Pahaba Control
Ultra Whitening
CellExosome HR
CellExosome SB
DEA No. 1405
Celonia CM
Ginseng Whitening
Dr. Cellmo
Royal GinsengCream
TOAS Rejuvenation
Nicotinamide,(S)
Vitamin B3 amide
Costem cell 5 N
Royal GinsengLotion
AAPE Skin Ampoule
CellExosome HE HR
Fantastic LightCream
Royal Ginseng Toner
Vita C Bright Serum
Vita C Bright Toner
Vitamin B3 Face Mask
Royal Ginseng Essence
Ultra Whitening Ample
TANIA PURECREAM
JUVEHEAL W Ampoule
Nicotinamidum (Latin)
BREXTEM S
NI-NICOTYL
Mediatric (Salt/Mix)
niacin - Vitamin B3
Dr. Color Effect Red
1yc5
DPC Aura Booster Mask
Dr Cellinme Mask Sheet
Opera_ID_775
Vita C Bright EyeCream
Miracle Laser Skin Mist
Niacin (as Vitamin B3)
Pyridine-3-carboxylamide
APLIN SPOT REMOVER
KARATICA I M CURE
VITAMIN B3 [FCC]
NICOTINAMIDE [MI]
TANIA PURE ESSENCE
VITA C BRIGHTCREAM
Pellagra-Preventing Factor
INTOMEDI HR PEPTIDE
VITAMIN B3 [HSDB]
VITAMIN B3 [INCI]
NICOTINAMIDE [JAN]
NYAAM NYAAM Vita Serum
RGO HYDRATION TONER
bmse000281
Miracle Moisturizer Essence
MolMap_000061
APLIN SPOT ALL KILL
MOISTIE PURE ESSENCE
VITAMIN B3 [VANDF]
DPC Whitening Booster Mask
SCHEMBL2926
AAPE Nutrient Facial Toner
Nicotinamide (JP17/INN)
NICOTINAMIDUM [HPUS]
NYAAM NYAAM Peptide Serum
Cellpium double essence toner
AAPE Continuous Renewal Mask
MLS001424246
Primerose Snail Hydro Essence
Shieldlife Whitening Ion Mask
Ultra V AQUA SHINE MASK
Ultra Whitening First Essence
NICOTINAMIDE [WHO-DD]
NICOTINAMIDE [WHO-IP]
by selected hyaluron day serum
Dr Cellinme Skin Care Ampoule
CELLPIUM REAL MASK PACK
Cellpium super richness ampoule
CAVIALL Wrinkle-Free PowerTox
Cellpium premiumEX hybrid toner
Revital Perfecting Dual Ampoule
SCHEMBL6278767
SGCUT00176
Daily Whitening Care Sheet Mask
Edge Cutimal Cat Whitening Mask
SCHEMBL19978192
BDBM27507
CELLBN MILKY TONE-UPCREAM
HY-B0150R
NYAAM NYAAM Skin Reborn Serum
A11HA01
Cellpium premiumEX hybrid essence
VITAMIN B3 [ORANGE BOOK]
BRIGHTUNING PEPTIDE AMPOULE
Nicotinamide, niacin, vitamin B3
HMS2052M21
HMS2090B05
HMS2093H03
HMS2236J03
HMS3370F21
HMS3394M21
HMS3655M20
HMS3713B22
HMS3884A16
Pharmakon1600-01505397
Ala-C Snail Cell Reparing Essence
AROCELL TIME REVERSE K I T
DR. GLODERM TABRX WHITENING
BCP07322
COSMEPURE BRIGHTENING CALMING
HY-B0150
THE SKIN HOUSE Vital BrightCream
THE SKIN HOUSE Vital BrightSerum
to_000073
ARILAC Brightening Mask Sheet Pack
Nicotinamide 1.0 mg/ml in Methanol
Nicotinamide, >=98.5% (HPLC)
Nicotinamide, >=99.5% (HPLC)
Tox21_111202
Tox21_201716
Tox21_302776
NICOTINAMIDUM [WHO-IP LATIN]
NSC759115
s1899
STL163867
THE SKIN HOUSE Vital Bright Toner
SFERANGS VITA C CAPSULEBOOSTER
AKOS005715850
Niveola P.H.c 3d Festival Mask Pack
Skin Project Ya Cooling Celluven Mask
THE SKIN HOUSE Vital BrightEmulsion
Tox21_111202_1
CCG-101149
CS-1968
DB02701
NC00399
NSC-759115
SB74497
Bk Cell 5days Of Secret Snow Whitening
EVECODE THREAD LIFTING MASK PACK
Nicotinamide 100 microg/mL in Methanol
Nicotinamide, >=98% (HPLC), powder
THE SKIN HOUSE Vital Bright Emulsion
THE SKIN HOUSE Vital Bright EyeCream
NCGC00093354-04
NCGC00093354-06
NCGC00093354-09
NCGC00256432-01
NCGC00259265-01
NIACIN (AS VITAMIN B3) [VANDF]
AS-13845
BN166252
COSMEPURE BRIGHTENING CALMING TONER
DERLADIE HerbalExtract BodySolution MIST
Nicotinamide, puriss., 99.0-101.0%
SY024804
DR. GLODERM TIME TO WHITENING MASK
FRESH MANDARIN AROMATHERAPY MASK27g
Nicotinamide, tested according to Ph.Eur.
SBI-0206826.P001
AN ADC SP INTENSIVE MOISTURE ESSENCE
CS-0694823
Derma Pella Facial Cleanser for Normal Skin
DR.ALTHEA POWER WHITENING GLUTATHIONE
FT-0631517
FT-0672696
FT-0773644
MIZON ENJOY VITAL UP TIME Whitening Mask
N0078
SW197779-3
The Hayan Cherry Blossom Brightening Essence
EN300-15612
Vitamin B3, meets USP testing specifications
C00153
D00036
DERMAHAN THE WHITENING MOISTURIZING MASK
Nicotinamide (Vitamin B3), analytical standard
AB00373895-13
AB00373895_15
AB00373895_16
Derma Pella Cleanser for Sensitive and Dry Skin
Nicotinamide, Vetec(TM) reagent grade, >=98%
A845925
AC-907/25014114
AROCELL X BELLE J SUPER POWER CELL AMPOULE
J9 ULTRA ADVANCED INTENSIVE SCALP SERUM V2
Q192423
LEBODY LAB RENEWAL DUAL EFFECT PEPTIDE SERUM
Q-201470
SR-01000721872-3
SR-01000721872-4
SR-01000721872-5
LEBODY LAB RENEWAL DUAL EFFECT IDEBENONE SERUM
MUSTUS DAILY HARVEST SQUEEZE TONE UP MASK PACK
PAPA RECIPE BOMBEE BRIGHTENING HONEY MASK PACK
SISEUNDEUSI LUMINANT MASK PACK STEP2(WHITENING)
Z33546463
F2173-0513
Vitamin B3;Nicotinic acid amide;Vitamin B3; Vitamin PP
Nicotinamide, British Pharmacopoeia (BP) Reference Standard
A186B02E-6C70-4E54-9739-79398D439AAA
Nicotinamide, European Pharmacopoeia (EP) Reference Standard
Vitamin B3, United States Pharmacopeia (USP) Reference Standard
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Vitamin B3, Pharmaceutical Secondary Standard; Certified Reference Material
Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture

Nicotinic acid, also known as niacin or vitamin B3, is a white crystal or crystalline powder, odorless or has a slight odor, slight sour taste.
Nicotinic acid is easily soluble in hot water, hot ethanol, alkaline water, propylene glycol, and chloroform.
Nicotinic acid is amphoteric and forms salts with acids as well as bases.

CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
EINECS Number: 200-441-0

Nicotinic acid can produce a variety of adverse effects, depending on the intake and health of the consumer.
The skin flushing reaction produced by nicotinic acid has been recognized for more than 70 years.
Nicotinic acid, melting point is 234-237℃.

Nicotinic acid is slightly soluble in water and ethanol; 100ml room temperature water can dissolve 1.6g.
When taken on an empty stomach, crystalline nicotinic acid in doses as small as 10 mg may produce a mild and transient, but noticeable, flushing reaction.

While not desirable, such reactions produce no known adverse consequences, and they are almost never perceptible when small amounts of nicotinic acid are taken in tablet or capsule form or consumed as part of food.
Nicotinic acid is sometimes referred to as nicotinic acid or nicotinamide and earlier called the P-P factor, antipellagra factor, antiblacktongue factor, and vitamin B4, niacin is available in several forms (niacin, niacinamide, niacinamide ascorbate, etc.) for use as a nutrient and dietary supplement.

Nicotinic acid is frequently identified with the B complex vitamin grouping.
Early in the research on niacin, a nutritional niacin deficiency was identified as the cause of pellagra in humans, blacktongue in dogs, and certain forms of dermatosis in humans.
Nicotinic acid deficiency is also associated with perosis in chickens as well as poor feathering of the birds.

Nicotinic acid and nicotinamide are colorless crystalline substances.
Nicotinic acid is slightly soluble in water and ethanol; nicotinamide is very soluble in water and moderately soluble in ethanol.

Nicotinic acids car boxyl group can form esters and anhydrides and can be reduced.
Both nicotinic acid and nicotinamide are very stable in dry form, but in solution nicotinamide is hydro lyzed by acids and bases to yield nicotinic.
The coenzyme forms of niacin are the pyridine nucleotides, NAD(H) and NADP(H).

In each of these compounds, the electron-withdrawing effect of the N-1 atom and the amide group of the oxidized pyridine nucleus enables the pyridine C-4 atom to react with many nucleophilic agents (e.g., sulfite, cyanide, and hydride ions).
It is the reaction with hydride ions (H?) that is the basis of the enzymatic hydrogen transfer by the pyridine nucleotides; the reaction involves the transfer of two electrons in a single step
Several substituted pyridines are antagonists of niacin in biological systems: pyridine-3-sulfonic acid, 3-acetylpyridine, isonicotinic acid hydrazine, 17 and 6-aminonicotinamide.

Nicotinic acid, Niacin or B3 is a water-soluble vitamin.
Derivatives of NADH, NADPH, NAD and NAD+ are a vitamin that has been affected in terms of energy, nuclear acids, protein fats and production.
Nicotinic acid cannot be included in the term vitamin B3.

Nicotinic acid was discovered by the oxidation of nicotine.
Nicotinic acid is derived from nicotinic acid + vitamin, as the name to be given to it is not intended to evoke nicotine.
Nicotinic acid can be seen in ancient texts that the name vitamin PP (short for the English term "pellegra prevention") was used for Nicotinic acid.

Nicotinic acid is a B vitamin that's made and used by your body to turn food into energy.
Nicotinic acid helps keep your nervous system, digestive system and skin healthy.
Nicotinic acid (vitamin B-3) is often part of a daily multivitamin, but most people get enough niacin from the food they eat.

Foods rich in Nicotinic acid include yeast, milk, meat, tortillas and cereal grains.
People use prescription Nicotinic acid (Niacor, Niaspan) to help control their cholesterol.
The recommended daily amount of Nicotinic acid for adult males is 16 milligrams (mg) a day and for adult women who aren't pregnant, 14 mg a day.

Nicotinic acid, or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.
The two most common forms of Nicotinic acid in food and supplements are nicotinic acid and nicotinamide.
The body can also convert tryptophan—an amino acid—to nicotinamide.

Nicotinic acid is water-soluble so that excess amounts the body does not need are excreted in the urine.
Nicotinic acid works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Nicotinic acid helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.

Niacin, also known as nicotinic acid, is an organic compound and a vitamer of vitamin B3, an essential human nutrient.
Nicotinic acid can be manufactured by plants and animals from the amino acid tryptophan.
Nicotinic acid is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.

Nicotinic acid as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness.
Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.

The amide derivative Nicotinic acid (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Although Nicotinic acid and nicotinamide are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, it does not reduce cholesterol nor cause flushing.

Nicotinic acid is recommended as a treatment for niacin deficiency because it can be administered in remedial amounts without causing the flushing, considered an adverse effect.
Nicotinic acid (also known as vitamin B3) is one of the water-soluble B vitamins.
Nicotinic acid is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside.

Nicotinic acid is naturally present in many foods, added to some food products, and available as a dietary supplement.
Nicotinic acid is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Nicotinic acid has a role as an antidote, an antilipemic drug, a vasodilator agent, a metabolite, an EC 3.5.1.19 (nicotinamidase) inhibitor, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a plant metabolite.

Nicotinic acid is a vitamin B3, a pyridinemonocarboxylic acid and a pyridine alkaloid.
Nicotinic acid is a conjugate acid of a nicotinate.
Nicotinic acid, or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.

The two most common forms of Nicotinic acid in food and supplements are nicotinic acid and nicotinamide.
The body can also convert tryptophan—an amino acid—to nicotinamide.
Nicotinic acid is water-soluble so that excess amounts the body does not need are excreted in the urine.

Nicotinic acid works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Nicotinic acid helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Nicotinic acid is also a prescription medication.

Amounts far in excess of the recommended dietary intake for vitamin functions will lower blood triglycerides and low density lipoprotein cholesterol (LDL-C), and raise blood high density lipoprotein cholesterol (HDL-C, often referred to as "good" cholesterol).
There are two forms: immediate-release and sustained-release Nicotinic acid.

Initial prescription amounts are 500 mg/day, increased over time until a therapeutic effect is achieved.
Immediate-release doses can be as high as 3,000 mg/day; sustained-release as high as 2,000 mg/day.
Despite the proven lipid changes, Nicotinic acid has not been found useful for decreasing the risk of cardiovascular disease in those already on a statin.

Nicotinic acid, on the other hand, is quite scarce in food and only recently started being sold as a supplement.
All three forms of vitamin B3 are converted to an important coenzyme called Nicotinic acid in the body.
Nicotinic acid is found in all living cells, and it plays a vital role in energy metabolism and maintaining proper cell functioning — particularly the functioning of our mitochondria, the power plants in our cells that turn food and oxygen into energy.

Nicotinic acid also plays an important role in protecting cells all over the body from age-related damage and decline in function.
While all three forms of vitamin B3 share common traits, each has a slightly different effect on the body and serves a different role when taken as a supplement.

Nicotinic acid (or nicotinic acid as it’s referred to in medical circles) was the third B vitamin to be discovered (hence the name B3).
Nicotinic acid wasn’t until about 1943, though, that a couple of doctors reported that niacin worked wonders in relieving the pain and stiffness associated with arthritis.
Nicotinic acid has a unique characteristic.

While not dangerous, Nicotinic acid can be uncomfortable, or even alarming, if you aren’t prepared for it.
Nicotinic acid, also known as vitamin B3, is a water-soluble vitamin.
Water-soluble vitamins are stored in the body in very limited amounts and are excreted through the urine.

Therefore, Nicotinic acid is a good idea to have them in your daily diet.
In addition to getting Nicotinic acid from dietary sources, the body can synthesize a form of niacin from the amino acid tryptophan.
Nicotinic acid causes the blood vessels to dilate or open up near the skin, which results in a hot, tingling sensation accompanied by a red flushing of the skin.

Generally, by starting with low amounts of Nicotinic acid (50 to 100 mg a day) and gradually increasing the dosage, a person can quickly build up a tolerance and avoid the flush.
Taking Nicotinic acid immediately following a meal will also lessen the flushing sensation.
Since Nicotinic acid isn’t something that drug companies can patent, it’s of little interest to them.

In fact, Nicotinic acid and niacinamide work on different circulatory systems and have their own unique benefits, making it important to take both.
Nicotinic acid in hydrochloric acid is highly suitable for checking the photometric accuracy of spectrometers in the UV range.
The Nicotinic acid spectrum shows a relatively broad maximum at the wavelengths 213 nm and 261 nm.

The Nicotinic acid filter solutions are filled and immediately fused under controlled conditions to become permanently airtight.
Nicotinic acid (NYE a sin) is used in combination with a healthy diet to lower bad cholesterol and increase good cholesterol.
Nicotinic acid is also used to decrease triglycerides.

Nicotinic acid can also be helpful in patients who have heart disease or who have had a heart attack.
Nicotinic acid may be used for other purposes; ask your health care provider or pharmacist if you have questions.
Nicotinic acid (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

The two coenzymes are required for oxidative reactions crucial for energy production, but they are also substrates for enzymes involved in non-redox signaling pathways, thus regulating biological functions, including gene expression, cell cycle progression, DNA repair and cell death.

Melting point: 236-239 °C(lit.)
Boiling point: 260C
Density: 1.473
refractive index: 1.5423 (estimate)
Flash point: 193°C
storage temp.: 2-8°C
solubility: 18g/l
pka: 4.85(at 25℃)
form: Powder
color: White to off-white
PH: 2.7 (18g/l, H2O, 20℃)
Odor: odorless to sl. odor, sour taste
Water Solubility: 1-5 g/100 mL at 17 ºC
Merck: 14,6525
BRN: 109591
BCS Class: 3
Stability: Stable. Incompatible with strong oxidizing agents. May be light sensitive.
InChIKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
LogP: 0.360

Nicotinic acid, 3-pyridinecarboxylicacid (Niacin), is effective in the treatment of all types ofhyperlipoproteinemia except type I, at doses above thosegiven as a vitamin supplement.
Nicotinic acid reduces VLDLsynthesis and, subsequently, its plasma products, IDL andLDL.
Plasma triglyceride levels are reduced because of thedecreased VLDL production.

Cholesterol levels are lowered,in turn, because of the decreased rate of LDL formationfrom VLDL.
Although niacin is the drug of choicefor type II hyperlipoproteinemias, Nicotinic acids use is limited becauseof the vasodilating side effects.
Flushing occurs inpractically all patients but generally subsides when thedrug is discontinued.

The hypolipidemic effects of Nicotinic acid may be caused byits ability to inhibit lipolysis (i.e., prevent the release ofFFAs and glycerol from fatty tissues).
Therefore, there is areduced reserve of FFA in the liver and diminution oflipoprotein biosynthesis, which reduces the production ofVLDL.
The decreased formation of lipoproteins leads to apool of unused cholesterol normally incorporated inVLDL.

Nicotinic acid excess cholesterol is then excreted throughthe biliary tract.
Nicotinic acid, also known as B3, nicotinic acid or nicotinamide, is an important enzymatic component required for the body to function normally.
This vitamin allows us to obtain energy from macronutrients (carbohydrates and fats).

Nicotinic acid, a very important micronutrient for energy synthesis, also contributes to the healthy functioning of the nervous and digestive systems.
In addition to these, Nicotinic acid is known that it is good for skin health and vitality, hair and eyes.
Nicotinic acid, an enzymatic component, has an important role in the metabolism of fats and sugars.

In this way, cells have the ability to provide the energy they need to continue their normal functions.
Nicotinic acid use of supplements containing niacin may be beneficial in terms of weight loss, as the substance will stimulate energy synthesis and help reduce the feeling of fatigue caused by weight loss.

Nicotinic acid also positively affects the vitality and health of the skin, eyes and hair and can be used for the treatment of skin conditions such as dermatitis, skin irritation and acne.
Adequate consumption of niacin contributes to the strengthening of the digestive and immune systems, while helping to fight oxidative stress.
Nicotinic acid also has positive effects on the health of the nervous system (it triggers units related to cognitive functions and memory).

Nicotinic acid deficiency can cause serious symptoms such as muscle weakness, digestive upsets (irritation of the mucus layer in the mouth, stomach, and intestines), loss of appetite, and skin rashes.
In more severe cases, Nicotinic acid can cause lesions in the central nervous system, leading to confusion and disorientation.
Studies have shown that Nicotinic acid can significantly lower cholesterol levels, but because the product is inexpensive, the pharmaceutical industry has not commercialized this supplement as a combined treatment for hypercholesteremia.

Since Nicotinic acid helps regulate fat and cholesterol levels, it can be used for the prevention or treatment of cardiovascular ailments.
Nicotinic acid, also called nicotinic acid and vitamin B3, water-soluble vitamin of the B complex.
Nicotinic acid is also called the pellagra-preventive vitamin because an adequate amount in the diet prevents pellagra, a chronic disease characterized by skin lesions, gastrointestinal disturbance, and nervous symptoms.

Nicotinic acid is interchangeable in metabolism with its amide, niacinamide (nicotinamide).
Like the vitamins thiamin (vitamin B1) and riboflavin (vitamin B2), niacin functions as part of a coenzyme involved in the metabolism of carbohydrates and acts to catalyze the oxidation of sugar derivatives and other substances.
Nicotinic acid, which was identified as a pellagra preventive in 1937, is widely distributed among plants and animals.

Nicotinic acid approximately 15 mg per day (1 mg = 0.001 gram) of nicotinic acid is required by humans.
In the intestinal tract, the Nicotinic acid tryptophan can be converted to niacin by bacterial action and thus can serve as a source for part of the required Nicotinic acid.
This explains scientists’ early observation that the protein in such foods as eggs and milk, both poor sources of niacin, can nevertheless prevent or cure pellagra.

Nicotinic acid is indicated to prevent vitamin deficiencies in pediatric and adult patients receiving parenteral nutrition as part of multivitamin intravenous injections.
Nicotinic acid oral tablets are indicated as a monotherapy or in combination with simvastatin or lovastatin to treat primary hyperlipidemia and mixed dyslipidemia
Nicotinic acid can also be used to reduce the risk of nonfatal myocardial infarctions in patients with a history of myocardial infarction and hyperlipidemia.

Nicotinic acid is also indicated with bile acid binding resins to treat atherosclerosis in patients with coronary artery disease and hyperlipidemia or to treat primary hyperlipidemia.
Finally Nicotinic acid is indicated to treat severe hypertriglyceridemia.
Nicotinic acid is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.

Nicotinic acid acts to decrease levels of very low density lipoproteins and low density lipoproteins, while increasing levels of high density lipoproteins.
Nicotinic acid can be converted to nicotinamide in the animal body and, in this form, is found as a component of two oxidation-reduction coenzymes, NAD and NADP.
The nicotinamide portion of the coenzyme transfers hydrogens by alternating between an oxidized quaternary nitrogen and a reduced tertiary nitrogen.

Enzymes that contain Nicotinic acid or NADP are usually called dehydrogenases.
They participate in many biochemical reactions of lipid, carbohydrate, and protein metabolism.
An example of an Nicotinic acid-requiring system is lactic dehydrogenase which catalyzes the conversion of lactic acid to pyruvic acid.

Nicotinic acid decreases formation and secretion of VLDL by the liver.
This action appears secondary to its ability to inhibit fatty acid mobilization from adipose tissue.
Circulating free fatty acids provide the main source of fatty acids for hepatic triglyceride synthesis, and lowering triglyceride synthesis lowers Nicotinic acid formation and secretion by the liver.

Since plasma VLDL is the source of Nicotinic acid, lowering VLDL can ultimately lower LDL.
In addition, nicotinic acid shifts LDL particles to larger (more buoyant) sizes.
The larger LDL particles are thought to be less atherogenic.

Nicotinic acid can also significantly increase plasma HDL levels; the mechanism is unknown.
Nicotinic acid is also known as vitamin B3, one of the B-complex vitamins.
Vitamins help to support the body's ability to make and break down natural compounds (metabolism) needed for good health.

Nicotinic acid (nicotinamide) is a different form of vitamin B3 and does not work the same as niacin.
Nicotinic acid is both a vitamin, i.e., an essential nutrient, marketed as a dietary supplement, and in the US, a prescription medicine.
As a Nicotinic acid, it is precursor of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

Severe deficiency of Nicotinic acid in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death.
Common psychiatric symptoms include irritability, poor concentration, anxiety, fatigue, loss of memory, restlessness, apathy, and depression.

Nicotinic acid is taken by mouth for high cholesterol and other fats.
Nicotinic acid is also used for low levels of a specific type of cholesterol, HDL.
Nicotinic acid is also used along with other treatments for circulation problems, migraine headache, Meniere's syndrome and other causes of dizziness, and to reduce the diarrhea associated with cholera.

Nicotinic acid is also taken by mouth to for preventing positive urine drug screens in people who take illegal drugs.
Nicotinic acid is taken by mouth for preventing vitamin B3 deficiency and related conditions such as pellagra.
Nicotinic acid is also taken by mouth for schizophrenia, hallucinations due to drugs, Alzheimer's disease and age-related loss of thinking skills, chronic brain syndrome, muscle spasms, depression, motion sickness, alcohol dependence, blood vessel swelling linked with skin lesions, and fluid collection (edema).

Some people take Nicotinic acid by mouth for acne, leprosy, attention deficit-hyperactivity disorder (ADHD), preventing premenstrual headache, improving digestion, protecting against toxins and pollutants, reducing the effects of aging, arthritis, lowering blood pressure, improving circulation, promoting relaxation, improving orgasms, and preventing cataracts.
Nicotinic acid is also used to improve exercise performance.

Nicotinic acid is a water-soluble vitamin that cannot be stored in body fat.
Nicotinic acid has two active components, nicotinic acid (niacin) and nicotinamide (niacinamide).
This vitamin plays a role in over 200 enzymatic reactions.

The body can synthesize Nicotinic acid in small amounts, provided it has sufficient stores of magnesium, vitamins B6 and B2, and tryptophan.
The latter is an essential amino acid (part of a protein)—that is, it is not produced by the body and must be obtained from food sources.
Nicotinic acid is a member of the B family of vitamins (B complex).

Nicotinic acida water-soluble vitamin.
Like the other B vitamins, Nicotinic acid helps make energy in your body.
Nicotinic acid helps your body use carbohydrates, fatty acids, and proteins.
Nicotinic acid is found in many plant and animal foods, such as yeast, meats (especially liver), grains, legumes, corn treated with alkali (such as corn used in tortillas), and seeds.

Nicotinic acid can be made by the liver from the amino acid tryptophan.
Nicotinic acid can be manufactured by plants and animals from the amino acid tryptophan.
Nicotinic acid is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.

Nicotinic acid as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide derivative Nicotinic acid (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).

Preparation
Nicotinic acid exists naturally in grain germs, meats and peanuts. It can also be synthesized artificially through the liquid phase method (potassium permanganate oxidation and nitric acid oxidation) and gas phase method (ozone oxidation, ammonia oxidation and air oxidation).
In the gas phase ammonia oxidation process, add 3-methyl pyridine, air and ammonia into the fluidized bed reactor and catalyze the reaction at 290～360℃,V2O5 to produce nicotinonitrile; then hydrolyze in sodium hydroxide aqueous solution at 160℃ to produce sodium nicotinate; finally, add hydrochloric acid to acidify, creating nicotinic acid.

In the potassium permanganate oxidation method, add potassium permanganate gradually at 80℃ to a mixture of 3-methyl pyridine and water, and then continue to mix for 30min at 85～90℃.
Distill to collect and reuse the unreacted 3-methyl pyridine and filter away the produced manganese dioxide.
Adjust the PH of the resulting nicotinic acid solution to 3.8～4.0 using hydrochloric acid, cool to 30℃ crystals, and filter to obtain crude nicotinic acid.

Dissolve the crude nicotinic acid in hot water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
6- hydroxyquinoline method Add sulfuric acid and quinoline into a reaction kettle and mix while maintaining heat at 150～160℃ for 5h.
Then with the temperature maintained at 180～220℃, slowly drop in nitric acid and the sulfuric acid mixture over the course of 36～40h.

While maintaining the temperature, mix for 2～3h to obtain a nicotinic acid solution and add water to dilute the solution.
Use 30％～33％ NaOH solution to neutralize the PH to 8～9. Cool and filter away the sodium sulfate and sodium nitrate crystals, add copper sulfate solution to the filtered liquid, and mix and heat to yield copper nicotinate precipitation.
Cool, filter and add the copper nicotinate to an adequate amount of water, drop in NaOH solution until PH>9 and the liquid is no longer blue, and filter away the produced cupric oxide.

Add a small amount of sodium sulfide solution to remove traces of copper and iron until the solution no longer produces black precipitate, and then filter.
Use hydrochloric acid to adjust the PH of the filtered liquid to 3.5～3.9, filter to yield crystals as crude nicotinic acid.

Dissolve the crude product in 12 times the amount of distilled water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product.
Yield is 35％～39％.
2-methyl-5-ethyl pyridine method With 2-methyl-5-ethyl pyridine as the raw ingredient, oxidize with nitic acid under high pressure and high temperatures, then decarboxylate to yield nicotinic acid.

Mechanisms:
Nicotinic acid reduces synthesis of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), lipoprotein(a) and triglycerides, and increases high-density lipoprotein cholesterol (HDL-C).[47] The lipid-therapeutic effects of niacin are partly mediated through the activation of G protein-coupled receptors, including hydroxycarboxylic acid receptor 2 (HCA2)and hydroxycarboxylic acid receptor 3 (HCA3), which are highly expressed in body fat.

HCA2 and HCA3 inhibit cyclic adenosine monophosphate (cAMP) production and thus suppress the release of free fatty acids (FFAs) from body fat, reducing their availability to the liver to synthesize the blood-circulating lipids in question.
A decrease in free fatty acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL-C turnover and reducing its production. Nicotinic acid also directly inhibits the action of diacylglycerol O-acyltransferase 2 (DGAT2) a key enzyme for triglyceride synthesis.

History
Huber first synthesized nicotinic acid in 1867. In 1914, Funk isolated nicotinic acid from rice polishings.
Goldberger, in 1915, demonstrated that pellagra is a nutritional deficiency.
In 1917, Chittenden and Underhill demonstrated that canine blacktongue is similar to pellagra.

In 1935, Warburg and Christian showed that niacinamide is essential in hydrogen transport as diphosphopyridine nucleotide (DPN).
In the following year, Euler et al. isolated DPN and determined its structure.
In 1937, Elvhehjem et al. cured blacktongue by administration of Nicotinic acid derived from liver.

In the same year, Fouts et al. cured pellagra with niacinamide.
In 1947, Handley and Bond established conversion of tryptophan to niacin by animal tissues
Carpenter found in 1951, that niacin in corn is biologically unavailable, and can be released only in very alkaline lime water of pH 11.

This explains why a Latin-American culture that used alkali-treated cornmeal to make tortilla was not at risk for niacin deficiency.
In 1955, Altschul and colleagues described large amounts of niacin as having a lipid-lowering property.
As such, Nicotinic acid is the oldest known lipid-lowering drug.[111] Lovastatin, the first 'statin' drug, was first marketed in 1987.

Uses
Nicotinic acid is an important factor in delivering hydrogen and fighting pellagra in organisms; it helps maintain skin and nerve health and stimulate digestion.
Nicotinic acid or niacinamide are used to treat and prevent pellagra.
This is a disease caused by niacin deficiency.

Nicotinic acid is also used to treat high cholesterol.
In some cases, niacin taken with colestipol can work as well as colestipol and a statin medicine.
Nicotinic acid USP granular is used for food fortification, as dietary supplement and as an intermediate of pharmaceuticals.

Nicotinic acid feed grade is used as vitamin for poultry, swines, ruminants, fish, dogs and cats, etc.
Nicotinic acid is also used as intermediate for nicotinic acid derivatives and technical applications.
Nicotinic acid is used to prevent and treat niacin deficiency (pellagra).

Nicotinic acid deficiency may result from certain medical conditions (such as alcohol abuse, malabsorption syndrome, Hartnup disease), poor diet, or long-term use of certain medications (such as isoniazid).
Nicotinic acid deficiency can cause diarrhea, confusion (dementia), tongue redness/swelling, and peeling red skin.

Nicotinic acid is also known as niacin and vitamin B3.
Nicotinic acid is a water-soluble conditioning agent that improves rough, dry, or flaky skin, helping smooth the skin and improve its suppleness.

Nicotinic acid enhances the appearance and feel of hair, by increasing body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
When used in the formulation of skin care products, niacinamide and niacin enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness.

Nicotinic acid is a precursor of the coenzymes NAD and NADP.
Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains.
Nicotinic acid is a water-soluble b-complex vitamin that is necessary for the growth and health of tissues.

Dietary deficiency is associated with pellagra.
Nicotinic acid was functions as a nutrient and dietary supplement that prevents pellagra.
The term "Nicotinic acid" has also been applied.

The term “Nicotinic acid” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid.
Nicotinic acid is essential for the proper functioning of the body, and a deficiency can lead to a condition called pellagra.
Supplementing with niacin can effectively treat and prevent pellagra.

Nicotinic acid is used as a medication to help lower elevated levels of LDL (low-density lipoprotein) cholesterol and triglycerides in the blood while increasing HDL (high-density lipoprotein) cholesterol.
Nicotinic acid is often prescribed for individuals with high cholesterol or those at risk of heart disease.

Due to its cholesterol-lowering properties, nicotinic acid can be prescribed to reduce the risk of heart attacks and strokes in certain patients with cardiovascular disease.
Nicotinic acid is sometimes used to treat hyperlipidemia, a condition characterized by high levels of lipids (fats) in the blood.
Nicotinic acid can also be used to manage dyslipidemia, a condition involving abnormal lipid levels in the blood, including high LDL cholesterol and triglycerides.

In some cases, nicotinic acid may be used to improve blood circulation in people with certain vascular conditions, like intermittent claudication, a symptom of peripheral arterial disease.
Nicotinic acid is sometimes used topically or in skincare products to improve the health and appearance of the skin.

Nicotinic acid can help address issues like acne, dry skin, and skin aging.
Nicotinic acid has been used in the prevention of migraines, although its effectiveness can vary from person to person.

Some studies have suggested that niacin supplementation may help improve certain symptoms of schizophrenia when used in combination with other medications.
Nicotinic acid is involved in various metabolic processes in the brain and may play a role in maintaining cognitive function.

Some research has explored its potential in Alzheimer's disease and age-related cognitive decline, though results are inconclusive.
High-dose Nicotinic acid has been used in certain detoxification programs for individuals trying to eliminate traces of illicit drugs, particularly marijuana, from their system.
This approach is controversial and should only be done under medical supervision.

Nicotinic acid is a crucial component in the production of energy within cells. It helps convert food into energy and is involved in various metabolic pathways.
Nicotinic acid has been shown to lower levels of Lp(a) cholesterol, which is associated with an increased risk of cardiovascular disease.
Nicotinic acid can be used in specific cases to target elevated Lp(a) levels.

Nicotinic acid, a form of niacin, is used in skincare products to address various skin conditions, such as acne, rosacea, and hyperpigmentation.
Nicotinic acid can help improve the appearance and texture of the skin.
Nicotinic acid has anti-inflammatory properties and is used in skincare products to soothe and calm irritated skin.

Nicotinic acid may also help reduce redness associated with certain skin conditions.
In addition to treating pellagra caused by niacin deficiency, nicotinic acid can sometimes be used to alleviate pellagra-like conditions that may result from other medical conditions or medications.

Safety Profile
Nicotinic acidv poison by intraperitoneal route.
Moderately toxic by ingestion, intravenous, and subcutaneous routes.
Human systemic effects: change in clotting factors, changes in platelet count.

Nicotinic acid, questionable carcinogen with experimental carcinogenic data.
When heated to decomposition it emits toxic fumes of NOx.

Synonyms
nicotinic acid
niacin
59-67-6
Pyridine-3-carboxylic acid
3-pyridinecarboxylic acid
3-Carboxypyridine
wampocap
vitamin B3
Niaspan
Acidum nicotinicum
nicolar
Apelagrin
Pellagrin
Akotin
Daskil
Efacin
Pelonin
Linic
nicamin
nicobid
nicocap
Enduracin
Nicodelmine
Niconacid
Nicotinipca
Pellagramin
Direktan
Nicacid
Nicangin
Peviton
Bionic
Diacin
Nicyl
Nyclin
Niac
Vitaplex N
Davitamon PP
Nico-Span
Tega-Span
Nicocidin
Nicocrisina
Niconazid
Nicotamin
Nicotene
Nicovasan
Nicovasen
Nipellen
SK-Niacin
Naotin
Niacor
Nicodon
Niconat
Nicosan 3
Nicosyl
Nicotil
Tinic
3-Carboxylpyridine
Nicotine acid
Nicodan
Nicoside
Slo-niacin
NICO
3-Picolinic acid
Nicotinsaure
Nico-400
Acide nicotinique
Pyridine-beta-carboxylic acid
Nicagin
anti-Pellagra vitamin
Caswell No. 598
PP Factor
Kyselina nikotinova
P.P. factor
Pellagra preventive factor
S115
Nicotinsaure [German]
Acido nicotinico
3-Pyridylcarboxylic acid
m-Pyridinecarboxylic acid
Niacin [USAN]
Kyselina nikotinova [Czech]
C6H5NO2
MFCD00006391
niacine
CCRIS 1902
Pyridine-carboxylique-3
EPA Pesticide Chemical Code 056701
Acide nicotinique [INN-French]
Acido nicotinico [INN-Spanish]
Acidum nicotinicum [INN-Latin]
HSDB 3134
Pyridine-carboxylique-3 [French]
AI3-18994
Pyridinecarboxylic acid, 3-
Niacin [USP]
SR 4390
BRN 0109591
Niacin extended release
Nicotinic acid [INN]
Vitamin B3 (Niacin)
Niacin (nicotinic acid)
EINECS 200-441-0
NIASPAN TITRATION STARTER PACK
NAH
CHEMBL573
beta-pyridinecarboxylic acid
NSC 169454
NSC-169454
niacin magnesium
niacin potassium
MLS000069603
Pyridine-.beta.-carboxylic acid
DTXSID1020932
UNII-2679MF687A
CHEBI:15940
Niacin (USP)
Niacinamide (TN)
2679MF687A
P.P. factor-pellagra preventive factor
Nicotinamide (TN)
CAS-59-67-6
NCGC00016268-02
Niacin (TN)
SMR000059024
[3H]nicotinic acid
[5, 6-3H]-niacin
EC 200-441-0
[3H]-Nicotinic acid
5-22-02-00057 (Beilstein Handbook Reference)
DTXCID10932
Nicotinicacid
Induracin
SR-01000722017
pellagra
Nikotinsaeure
Ncotnc acd
preventative factor
Niacin-Vitamin B3
Niaspan (TN)
3PyrCOOH
Niacor (TN)
Nicotinic Acid,(S)
Niacinamide Astra Brand
Niacinamide Merck Brand
Spectrum_001063
Nicotinic acid, Ph Eur
NIACIN [VANDF]
NIACIN [HSDB]
NIACIN [INCI]
5-pyridinecarboxylic acid
NIACIN [FCC]
NIACIN [USP-RS]
Opera_ID_1346
Prestwick0_000881
Prestwick1_000881
Prestwick2_000881
Prestwick3_000881
Pyridine-3-carbonic acid
Spectrum2_000006
Spectrum3_000515
Spectrum4_000965
Spectrum5_001287
VITAMIN B-3
3-Pyridyl carboxylic acid
Nicotinic acid-d3(major)
Nicotinamide-carbonyl-14C
Nicotinic acid; (Niacin)
WLN: T6NJ CVQ
3-pyridine carboxylic acid
Astra Brand of Niacinamide
bmse000104
D06NVJ
Merck Brand of Niacinamide
Niacinamide Jenapharm Brand
Nicotinic acid, >=98%
Nicotinic acid, USP grade
SCHEMBL1433
Nicotinamide (JP15/INN)
Nicotinic acid [INN:BAN]
Nicotinic acid; (Niacin)
NICOTINIC ACID [MI]
Niacinamide Pharmagenix Brand
Oprea1_514398
VITAMIN B3 [VANDF]
BSPBio_000662
BSPBio_002069
KBioGR_001309
KBioSS_001543
NIACIN [ORANGE BOOK]
NICOTINIC ACID [JAN]
Nicotinic acid (Vitamin B3)
BIDD:GT0644
DivK1c_000695
Nicotinic acid (JP17/INN)
SIMCOR COMPONENT NIACIN
SPECTRUM1500430
.beta.-Pyridinecarboxylic acid
Jenapharm Brand of Niacinamide
SPBio_000011
SPBio_002881
ADVICOR COMPONENT NIACIN
NIACIN [USP MONOGRAPH]
NICOTINIC ACID [VANDF]
BPBio1_000730
GTPL1588
GTPL1594
NICOTINIC ACID [MART.]
NICOTINIC ACID [WHO-DD]
NICOTINIC ACID [WHO-IP]
Pharmagenix Brand of Niacinamide
BDBM23515
HMS502C17
KBio1_000695
KBio2_001543
KBio2_004111
KBio2_006679
KBio3_001569
ABT-919
NIACIN COMPONENT OF SIMCOR
NICOTINIC ACID [EMA EPAR]
NINDS_000695
HMS1570B04
HMS1920P17
HMS2091H22
HMS2097B04
HMS2236A05
HMS3259K21
HMS3371E07
HMS3655K08
HMS3714B04
NIACIN COMPONENT OF ADVICOR
Pharmakon1600-01500430
Nicotinic acid, analytical standard
BCP16301
HY-B0143
STR00112
Tox21_110337
Tox21_201420
Tox21_302904
AC8691
BBL037343
CCG-38340
NICOTINIC ACID [EP IMPURITY]
Nicotinic acid, for synthesis, 99%
NSC169454
NSC757241
s1744
STK301803
NICOTINIC ACID [EP MONOGRAPH]
AKOS000118980
Nicotinic acid, >=99.5% (HPLC)
Tox21_110337_1
AM81316
CS-1946
DB00627
LS-2334
NC00524
Nicotinic Acid 1.0 mg/ml in Methanol
NSC-757241
PS-4255
SDCCGMLS-0066610.P001
IDI1_000695
NCGC00016268-01
NCGC00016268-03
NCGC00016268-04
NCGC00016268-05
NCGC00016268-08
NCGC00016268-09
NCGC00094734-01
NCGC00094734-02
NCGC00256537-01
NCGC00258971-01
AC-22484
ACIDUM NICOTINICUM [WHO-IP LATIN]
BP-21419
NCI60_001041
Nicotinic acid, NIST(R) SRM(R) 148
Nicotinic acid, plant cell culture tested
SY011111
SBI-0051456.P003
Nicotinic Acid [Matrix for MALDI-TOF/MS]
AB00052050
FT-0600004
FT-0672715
FT-0672716
FT-0672717
FT-0672718
FT-0773496
N0082
N1103
Nicotinic acid 10 microg/mL in Acetonitrile
Nicotinic acid, purum, >=99.0% (HPLC)
SW197229-3
EN300-16693
C00253
D00049
Niacinamide, Nicotinic acid amide, Nicotinamide
Nicotinic acid, SAJ special grade, >=99.5%
AB00052050-13
AB00052050_14
AB00052050_15
Nicotinic acid, meets USP testing specifications
AC-907/25014105
L001199
METHYL NICOTINATE IMPURITY A [EP IMPURITY]
Nicotinic acid, Vetec(TM) reagent grade, >=98%
Q134658
J-523605
SR-01000722017-2
SR-01000722017-3
SR-01000722017-4
Z56755709
3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E
F2191-0082
Niacin, United States Pharmacopeia (USP) Reference Standard
Nicotinic acid, certified reference material, TraceCERT(R)
Nicotinic acid, European Pharmacopoeia (EP) Reference Standard
Nicotinic acid, matrix substance for MALDI-MS, >=99.5% (HPLC)
InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9
Nicotinic acid, for inorganic trace analysis, >=99.999% (metals basis)
Niacin (Nicotinic Acid), Pharmaceutical Secondary Standard; Certified Reference Material
101113-41-1
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98%

NICOTINYL ALCOHOL HF N° CAS : 62756-44-9 Nom INCI : NICOTINYL ALCOHOL HF Nom chimique : 3-Pyridinemethanol, hydrofluoride (1:1) N° EINECS/ELINCS : 700-352-1 (L) Antiplaque : Aide à protéger contre la formation de plaque dentaire

NIPACIDE BIT 20; Exocide 20, 1,2-benzisothiazol-3(2H)-one, Benzisothiazolinone, Benzisothiazolin-3-one, Cas No: 2634-33-5

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a polyethylene glycol derivative of hydrogenated castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is produced by the ethoxylation of hydrogenated castor oil, which involves treating the oil with ethylene oxide.

CAS Number: 61788-85-0
Molecular Formula: C57H110O9 (C2H4O)n
EINECS number: 500-147-5

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can be used to emulsify and solubilize oil-in-water (o/w) emulsions.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)0 is a commercial product name for PEG-40 Hydrogenated Castor Oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a specific formulation or brand of PEG-40 Hydrogenated Castor Oil that is manufactured by NIKKOL Group, a company specializing in the production of cosmetic and personal care ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is commonly used in the cosmetic and personal care industry as an emulsifier, surfactant, solubilizer, and fragrance ingredient.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) has surfactant properties, allowing it to help stabilize and emulsify oil and water-based formulations.
It can enhance the texture and spreadability of cosmetic products and improve the solubility of certain ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can act as a fragrance carrier, aiding in the dispersion of fragrances throughout formulations.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is primarily used as an emulsifier, surfactant, and solubilizer in cosmetic and personal care formulations.
It helps to stabilize emulsions, allowing the blending of oil and water-based ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) also aids in the dispersion of insoluble substances in water-based products and improves the solubility of certain ingredients.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can contribute to the texture and sensory attributes of cosmetic products.
It can enhance the spreadability, smoothness, and overall feel of formulations, making them easier to apply and providing a pleasant sensory experience to the user.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is compatible with a wide range of ingredients commonly used in cosmetic and personal care products.
It can be used in various formulations, including creams, lotions, serums, shampoos, conditioners, and bath products.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)n is a process that involves adding hydrogen to castor oil, resulting in a more stable and solid form.

This process alters the properties of castor oil, making it more suitable for certain applications.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a company specializing in the development, production, and distribution of cosmetic and personal care ingredients.
They offer a wide range of ingredients, including emulsifiers, surfactants, moisturizers, and active ingredients.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is typically an amber-colored liquid with a slightly thick consistency.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) may have a mild fatty or waxy odor.
The product is generally miscible in both water and oil, which allows it to be easily incorporated into various cosmetic formulations.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) acts as an effective emulsifier, helping to create stable emulsions by reducing the surface tension between oil and water phases. It assists in the formation and stabilization of oil-in-water (o/w) emulsions, where oil droplets are dispersed in a continuous water phase.
As a surfactant, NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) reduces the interfacial tension between two immiscible substances, such as oil and water.

This property enables it to enhance the wetting, dispersing, and foaming capabilities of cosmetic products.
NIKKOL HCO-40 can act as a solubilizer, aiding in the dispersion and solubilization of lipophilic (oil-soluble) ingredients in water-based formulations.
It helps to improve the transparency and stability of solutions containing oil-soluble substances.

When stored under proper conditions, NIKKOL HCO-40 has good stability and a reasonably long shelf life.
However, it is recommended to follow the manufacturer's guidelines for storage temperature and conditions to ensure product quality and efficacy over time.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil), including NIKKOL HCO-40, is typically considered safe for use in cosmetics and personal care products.
It is approved by regulatory authorities such as the U.S. Food and Drug Administration (FDA) and is widely used in the industry.
However, it is important to comply with relevant regulations and guidelines specific to the intended market and ensure that the product meets all necessary safety standards.

As with any cosmetic ingredient, it is important to ensure the quality and safety of NIKKOL HCO-40.
The manufacturer should provide information on the specifications, handling guidelines, recommended usage levels, and potential safety considerations associated with their product.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is advisable to consult the manufacturer's documentation or contact them directly for specific technical details and safety information.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) in the name refers to the polyethylene glycol chain length, indicating the number of ethylene oxide units that are attached to the hydrogenated castor oil molecule.
Different chain lengths can result in variations in the properties and performance of the ingredient.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is utilized in various cosmetic and personal care products, including creams, lotions, serums, shampoos, conditioners, and bath products.
It provides formulation stability, emulsification, and enhances product sensory attributes.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) acts as a solubilizer for systems with much alcohol.
It is a white to pale yellow liquid, petrolatum-like or waxy substance. NIKKOL HCO-40 is used in cosmetics.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is used in cosmetics as a solubiliser, emulsifier, surfactant and emollient.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is derived from Castor oil and is useful in producing products that disperse in water whilst offering good moisturising properties.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is an emollient and emulsifying agent created from a mixture of synthetic polyethylene glycol (PEG) + natural castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) also helps other ingredients solubilize in a formula which improves both aesthetics and performance.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) or liquid raw material, this vegetable-based solubiliser is also used as a surfactant and cleanser in cosmetic preparations, and was designed for use as an emulsifier in aqueous formulations containing a large water phase.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) has a yellow colour with a mild odour.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a combination of polyethylene glycol and hydrogenated castor oil.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is naturally occurring oil extracted from castor beans from plant Ricinus communis.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a colorless to pale yellow liquid with a distinct taste and odor.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is rich in triglycerides and fatty acids like oleic acid, ricinoleic acid, and linoleic acid.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is used in many cosmetic products.
A combination of both PEG-40 and castor oil makes it contain the benefits of both the molecules in a single molecule.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)’s mostly used as an emulsifier and surfactant but most often it is used to solubilize fragrances into water-based formulas.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil)l is a synthetic ingredient used in a variety of cosmetics and skincare products to help improve the texture and effectiveness of the formulation.
The main functions of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) are as a surfactant, emulsifier, and emollient.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil), Crouret 40 is a vegetable-derived nonionic surfactant which finds widespread use as an emollient, oil-in water emulsifier, lubricant and effective solubiliser.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can act as a wetting agent in styling waxes and imparts superfatting benefits in detergent systems.

Boiling point: 348℃[at 101 325 Pa]
Density: 0.983[at 20℃]
vapor pressure: 0Pa at 25℃
Flash point: 242℃
storage temp.: 4°C, protect from light
Odor: at 100.00?%. bland
Water Solubility: 500μg/L at 20℃
LogP: 8 at 25℃

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a derivative of hydrogenated castor oil that is commonly used in cosmetics as an emulsifying agent and fragrance ingredient. It has been approved by the FDA for external use and is generally considered safe in concentrations up to 100%.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) and other similar compounds are typically not known to cause skin irritation.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is a softening and emulsifying agent created from a mixture of synthetic polyethylene glycol (PEG) + natural castor oil.
It also helps dissolve other ingredients into a formula that improves both aesthetics and performance.
Basically, it combines water and oil substances and allows the other ingredients to dissolve in a sticky way for a pleasant result.

The weight and size of this ingredient is too large to penetrate beyond the skin surface, but that's okay - this type of emollient is required on the surface to minimize moisture loss and give it a soft feel.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is considered non-sensitizing and safe for use in cosmetics, with defined concentrations ranging from 0.00007% to 22% (based on a 2015 report).

However, there is some debate regarding the safety of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil).
While it has received FDA approval for external use, the Cosmetics Database has classified it as potentially hazardous.
According to the database, there is a chance of contamination with potentially harmful impurities.

The potential toxicity of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is related to the manufacturing process known as ethoxylation.
During this process, NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is treated with ethylene oxide, which is derived from petroleum.
This process may introduce a contaminant called 1,4-dioxane, which is known to be a carcinogen.

However, the presence of 1,4-dioxane is not guaranteed in every batch.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is an amber-colored liquid with a slightly thick consistency and a mild natural fatty scent.
It is commonly used as an emulsifier, surfactant, and fragrance ingredient in various cosmetic products.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) and PEG Hydrogenated Castor Oils, including PEG 40, belong to a group of polyethylene glycol derivatives derived from castor oil.
They are widely used in the cosmetic industry, serving as skin conditioning agents and surfactants in over 500 formulations.
The length of the polymer chain varies depending on the amount of ethylene oxide used during synthesis.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is important to note that the maximum concentration used in animal sensitization studies was 50% for PEG Castor Oils and 100% for PEG Hydrogenated Castor Oils.
Therefore, it is generally considered safe to use PEG Castor Oils in cosmetic formulations at concentrations up to 50%, and PEG Hydrogenated Castor Oils as intended for cosmetic use.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil), which include PEG Castor Oils, are nonionic surfactants with a wide range of applications in industrial and household formulations.
They are used as cleaning agents, antistatic agents, dispersants, emulsifiers, defoamers, and softeners in textile, home care, personal care, and agricultural products.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) are derived from castor oil and contain traditional fatty acids along with the unique ricinoleic acid.

Uses
NIKKOL HCO-40 is widely used as an emulsifier in cosmetic formulations.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to create stable emulsions by allowing the blending of oil and water-based ingredients.
This is particularly useful in the production of creams, lotions, and other emulsion-based products.

As a surfactant, NIKKOL HCO-40 reduces the surface tension between different substances, such as oil and water.
It helps to improve the wetting, dispersing, and foaming properties of cosmetic products.
This makes it suitable for use in shampoos, body washes, and other cleansing formulations.

NIKKOL HCO-40 acts as a solubilizer, aiding in the dispersion and solubilization of lipophilic (oil-soluble) ingredients in water-based formulations.
It helps to improve the transparency and stability of solutions containing oil-soluble substances.
This is beneficial in products such as serums, toners, and sprays.

NIKKOL HCO-40 can also be used as a fragrance ingredient.
It helps to disperse and carry fragrances throughout cosmetic formulations, ensuring their even distribution and enhancing the scent of the final product.
Due to its emulsifying properties, NIKKOL HCO-40 can contribute to the texture and sensory attributes of cosmetic products.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can improve the spreadability, smoothness, and overall feel of formulations, making them easier to apply and providing a pleasant user experience.
NIKKOL HCO-40 finds application in a wide range of cosmetic and personal care products, including creams, lotions, serums, moisturizers, cleansers, shampoos, conditioners, body washes, and various other skincare and haircare formulations.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is used to solubilize vitamins, water insoluble active substances and essential oils in water or mixtures of water and alcohol.
NIKKOL HCO-40 is often used in moisturizing creams and lotions.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to emulsify water and oil-based ingredients, allowing for a smooth and creamy texture.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) also contributes to the spreadability and absorption of the product, leaving the skin feeling moisturized and hydrated.
NIKKOL HCO-40 is utilized in various haircare formulations, such as shampoos, conditioners, and hair styling products.
It helps to create a stable emulsion, ensuring the even distribution of ingredients and enhancing the efficacy of the product.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) can also improve the texture of haircare products, making them easier to apply and rinse off.
Due to its surfactant properties, NIKKOL HCO-40 is commonly used in body washes, shower gels, and bath products.
It helps to create a luxurious lather, improving the cleansing and foaming properties of the formulation.

NIKKOL HCO-40 is commonly used as a key ingredient in cleansing oils.
It helps to emulsify and lift away dirt, impurities, and makeup from the skin.
It provides a gentle and effective cleansing experience, leaving the skin clean and refreshed.

Due to its emulsifying properties, NIKKOL HCO-40 is utilized in makeup removers.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) assists in breaking down and removing makeup, including waterproof formulations.
It helps to dissolve and lift away makeup without excessive rubbing or irritation.

NIKKOL HCO-40 is incorporated into body lotions and body butters to enhance their emollient and moisturizing properties.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to create a smooth and creamy texture that spreads easily on the skin.
It contributes to the long-lasting hydration and nourishment of the skin.

NIKKOL HCO-40 finds application in lip balms and lipsticks. It helps to create a soft and smooth texture, ensuring easy application on the lips.
It contributes to the moisturizing and conditioning properties of lip products, keeping the lips hydrated and protected.
NIKKOL HCO-40 is sometimes incorporated into anti-aging formulations, such as serums and creams.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) helps to deliver active ingredients, such as antioxidants and peptides, to the skin effectively.
It enhances the absorption and penetration of these ingredients, promoting their efficacy in reducing the signs of aging.
NIKKOL HCO-40 is used in the formulation of personal care wipes, including makeup wipes and baby wipes.

NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) aids in the dispersion of cleansing agents and moisturizing ingredients on the wipe, ensuring their efficient release when in contact with the skin.
NIKKOL HCO-40 is sometimes included in sunscreen formulations.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) assists in the even distribution of sun-protective ingredients, such as UV filters, ensuring their effective coverage on the skin.

NIKKOL HCO-40 is used in various decorative cosmetics, including foundations, BB creams, and liquid lipsticks.
It helps to create smooth and lightweight formulations, improving the blendability and application of the product.
It can also enhance the dispersibility of pigments, ensuring even color distribution.

NIKKOL HCO-40 is utilized as a fragrance ingredient in perfumes, colognes, and body sprays.
It helps to solubilize and disperse the fragrance oils, allowing for a well-rounded and long-lasting scent experience.
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) may cause skin irritation, especially in individuals with sensitive or compromised skin.

Safety
Prolonged or repeated contact with concentrated forms of the ingredient may increase the risk of irritation.
Contact with the eyes can lead to irritation, redness, and discomfort.
Avoid direct contact with the eyes and flush with water if it occurs.

Some individuals may develop an allergic or sensitization reaction to NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil).
If you experience any signs of allergic reaction, such as itching, redness, rash, or swelling, discontinue use and consult a healthcare professional.

Inhalation
Inhalation of aerosolized forms or fine particles of NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) may irritate the respiratory system.
Adequate ventilation should be maintained when working with powdered or aerosol forms of the ingredient.

Environmental Impact
NIKKOL HCO-40 (PEG-40 Hydrogenated Castor Oil) is considered to have low environmental toxicity.
However, it is important to handle and dispose of the ingredient in accordance with local regulations to prevent any potential harm to aquatic life or the environment.

Synonyms
NIKKOL HCO 60
HYDROGENATED CASTOR OIL
ETHOXYLATED
POLYETHYLENE GLYCOL 2000 HYDROGENATED CASTOR OIL
POLYOXYETHYLENE (40) HYDROGENATED CASTOR OIL
CREMOPHOR RH 40
CREMOPHOR RH 40/6
HCO 40 HCO 50 HCO 60
akypo rox CO400
alkamuls CRH/40-C;castor oil (ricinus communis)
hydrogenated, ethoxylated (40 mol
EO average molar ratio)
cremophor RH 40;croduret 40
emanon CH-40
findet ARH-52; lipocol HCO-40;nikkol HCO-40
nikkol HCO-40 pharm;polyethylene glycol40 hydrogenated castor oil
polyoxyethylene (40) hydrogenated castor oil
Polyoxyl 40 hydrogenated castor oil [NF]
7YC686GQ8F
02NG325BQG
0ZNO9PJJ9J
R07D3A9614
0WZF1506N9
MH590ECD4O
WE09129TH5
43SW2U113W
61788-85-0
Ethoxylated hydrogenated castor oil
UNII-02NG325BQG
UNII-7YC686GQ8F
Polyethylene glycol (25) hydrogenated castor oil
Polyethylene glycol (30) hydrogenated castor oil
Polyethylene glycol (35) hydrogenated castor oil
Polyethylene glycol (45) hydrogenated castor oil
Polyethylene glycol (5) hydrogenated castor oil
Polyethylene glycol (50) hydrogenated castor oil
Polyethylene glycol (54) hydrogenated castor oil
PEG-100 Hydrogenated castor oil
PEG-16 Hydrogenated castor oil
PEG-20 Hydrogenated castor oil
PEG-200 Hydrogenated castor oil
PEG-25 Hydrogenated castor oil
PEG-30 Hydrogenated castor oil
PEG-35 Hydrogenated castor oil
Polyethylene glycol (55) hydrogenated castor oil
Polyethylene glycol (60) hydrogenated castor oil
Polyethylene glycol (7) hydrogenated castor oil
Polyethylene glycol (80) hydrogenated castor oil
PEG-40 Hydrogenated castor oil
PEG-45 Hydrogenated castor oil
PEG-5 Hydrogenated castor oil
Polyethylene glycol 2000 hydrogenated castor oil
PEG-50 Hydrogenated castor oil
PEG-54 Hydrogenated castor oil
PEG-55 Hydrogenated castor oil
PEG-60 Hydrogenated castor oil
PEG-7 Hydrogenated castor oil
PEG-80 Hydrogenated castor oil
Polyethylene glycol (100) hydrogenated castor oil
Polyethylene glycol (16) hydrogenated castor oil
Polyethylene glycol (200) hydrogenated castor oil
Castor oil, hydrogenated, ethoxylated, HCO 50
Polyoxyethylene (5) hydrogenated castor oil
Polyoxyethylene (50) hydrogenated castor oil
Polyoxyethylene (54) hydrogenated castor oil
Polyoxyethylene (55) hydrogenated castor oil
Polyoxyethylene (100) hydrogenated castor oil
Polyoxyethylene (16) hydrogenated castor oil
Polyoxyethylene (200) hydrogenated castor oil
Polyoxyethylene (25) hydrogenated castor oil
Polyoxyethylene (30) hydrogenated castor oil
Polyoxyethylene (35) hydrogenated castor oil
Polyoxyethylene (40) hydrogenated castor oil
Polyoxyethylene (45) hydrogenated castor oil
Castor oil, hydrogenated, ethoxylated, HCO 60
Polyoxyethylene hydrogenated castor oil 60
CCRIS 6926
Cremophor RH 40
Cremophor RH 40/60
HCO 40
HCO 50
HCO 60
Hydrogenated castor oil, ethoxylated
Nikkol HCO 60
Polyoxyethylene (80) hydrogenated castor oil
Castor oil, hydrogenated, ethoxylated
Castor oil, hydrogenated, ethoxylated, HCO 40
Polyoxyethylene (60) hydrogenated castor oil
Polyoxyethylene (7) hydrogenated castor oil
Cremophor RH40
UNII-0ZNO9PJJ9J
UNII-MH590ECD4O
UNII-R07D3A9614
UNII-WE09129TH5
UNII-43SW2U113W
UNII-0WZF1506N9
Polyoxyl 40 hydrogenated castor oil

SYNONYMS Methylparaben; 4-Hydroxybenzoic Acid Methyl Ester; methyl 4-hydroxybenzoate; Benzoic acid, 4-hydroxy-, methyl ester; CAS NO:99-76-3

SYNONYMS Methylparaben;nıpagin sodium ; sodium nipajin;4-Hydroxybenzoic Acid Methyl Ester; methyl 4-hydroxybenzoate; Benzoic acid, 4-hydroxy, methyl ester; CAS NO:5026-62-0

N-isopropylhydroxylamine; 5080-22-8; 2-Propanamine, N-hydroxy-; N-(propan-2-yl)hydroxylamine; N-hydroxypropan-2-amine; N-Isopropylhydroxylamine oxalate salt; N-hydroxypropan-2-amine; N-hydroxypropan-2-amine sulfate (2:1) CAS NO.: 5080-22-8

N-Isopropyl Hydroxylamine is a colorless to light yellow liquid with a characteristic odor.
N-Isopropyl Hydroxylamine is soluble in water, alcohol, and ether.
N-Isopropyl Hydroxylamine is a weak base and reacts with acids to form salts.

CAS Number: 7681-93-8

APPLICATIONS

N-Isopropyl Hydroxylamine is used as an intermediate in the production of pharmaceuticals and agrochemicals.
N-Isopropyl Hydroxylamine is used as a reducing agent in organic synthesis.
N-Isopropyl Hydroxylamine is used as a stabilizer for rubber and polymers.

N-Isopropyl Hydroxylamine is used in the synthesis of nitroso compounds.
N-Isopropyl Hydroxylamine is used in the production of antioxidants and corrosion inhibitors.

N-Isopropyl Hydroxylamine is used as an inhibitor in the polymerization of vinyl monomers.
N-Isopropyl Hydroxylamine is used in the synthesis of oximes.

N-Isopropyl Hydroxylamine is used in the purification of aldehydes and ketones.
N-Isopropyl Hydroxylamine is used as an intermediate in the production of dyestuffs.

N-Isopropyl Hydroxylamine is used as an antioxidant in fuels and lubricants.
N-Isopropyl Hydroxylamine is used as a polymerization inhibitor in the production of acrylics and methacrylics.
N-Isopropyl Hydroxylamine is used as a corrosion inhibitor in cooling water systems.

N-Isopropyl Hydroxylamine is used as a reducing agent in the synthesis of hydrazones.
N-Isopropyl Hydroxylamine is used in the production of biocides and fungicides.

N-Isopropyl Hydroxylamine is used as a reagent in the determination of aldehydes and ketones.
N-Isopropyl Hydroxylamine is used in the synthesis of heterocyclic compounds.

N-Isopropyl Hydroxylamine is used as an antioxidant in food packaging materials.
N-Isopropyl Hydroxylamine is used as a chelating agent in the production of metal ions.
N-Isopropyl Hydroxylamine is used as an inhibitor in the synthesis of ethylene oxide.

N-Isopropyl Hydroxylamine is used as an intermediate in the production of perfume ingredients.
N-Isopropyl Hydroxylamine can be used as an antioxidant in the polymerization of styrene.

N-Isopropyl Hydroxylamine is used as a reducing agent in organic synthesis reactions.
N-Isopropyl Hydroxylamine is used in the synthesis of pharmaceutical compounds.

N-Isopropyl Hydroxylamine can be used as an oxygen scavenger in the corrosion protection of metals.
N-Isopropyl Hydroxylamine can be used to remove iron oxide deposits in industrial equipment.
N-Isopropyl Hydroxylamine is used in the manufacture of rubber accelerators.

N-Isopropyl Hydroxylamine can be used to reduce nitro compounds to amines.
N-Isopropyl Hydroxylamine is used as a blocking agent for the protection of carbonyl groups in organic synthesis.

N-Isopropyl Hydroxylamine is used as an intermediate in the production of agrochemicals.
N-Isopropyl Hydroxylamine can be used as an initiator in the polymerization of vinyl monomers.

N-Isopropyl Hydroxylamine is used in the synthesis of N-hydroxylamines.
N-Isopropyl Hydroxylamine can be used as a stabilizer for nitroxyl radicals in the formation of free radicals.

N-Isopropyl Hydroxylamine is used in the production of antioxidants for the prevention of degradation of polymers.
N-Isopropyl Hydroxylamine can be used in the synthesis of anti-inflammatory drugs.
N-Isopropyl Hydroxylamine is used in the preparation of benzyl oxime derivatives.

N-Isopropyl Hydroxylamine can be used in the preparation of 1,2,3,4-tetrahydroquinolines.
N-Isopropyl Hydroxylamine is used in the synthesis of isoxazole derivatives.

N-Isopropyl Hydroxylamine can be used in the preparation of imidazole derivatives.
N-Isopropyl Hydroxylamine is used in the synthesis of heterocyclic compounds.

N-Isopropyl Hydroxylamine can be used as a reducing agent for the synthesis of organophosphorus compounds.
N-Isopropyl Hydroxylamine is used in the production of corrosion inhibitors for the protection of metals.

N-Isopropyl Hydroxylamine can be used as an intermediate in the synthesis of pesticides.
N-Isopropyl Hydroxylamine is used in the synthesis of biologically active molecules.

N-Isopropyl Hydroxylamine can be used in the production of antioxidants for food preservation.
N-Isopropyl Hydroxylamine is used in the synthesis of inhibitors for the treatment of Alzheimer's disease.

N-Isopropyl Hydroxylamine is used as a reagent in organic synthesis.
N-Isopropyl Hydroxylamine is an important intermediate in the production of pharmaceuticals and agrochemicals.

N-Isopropyl Hydroxylamine is used in the preparation of anti-tumor agents.
N-Isopropyl Hydroxylamine is used as a reducing agent in the synthesis of various compounds.
N-Isopropyl Hydroxylamine is used in the manufacture of rubber antioxidants.

N-Isopropyl Hydroxylamine is used as a stabilizer for emulsion polymerization.
N-Isopropyl Hydroxylamine is used as an antioxidant in the production of synthetic rubber.

N-Isopropyl Hydroxylamine is used as a corrosion inhibitor in cooling water systems.
N-Isopropyl Hydroxylamine is used in the manufacture of electronic chemicals.

N-Isopropyl Hydroxylamine is used in the production of photographic chemicals.
N-Isopropyl Hydroxylamine is used in the synthesis of dyes and pigments.

N-Isopropyl Hydroxylamine is used in the production of high-performance coatings.
N-Isopropyl Hydroxylamine is used as a polymerization inhibitor.
N-Isopropyl Hydroxylamine is used as a stabilizer for polyurethane foams.

N-Isopropyl Hydroxylamine is used as a flame retardant in plastics.
N-Isopropyl Hydroxylamine is used in the production of epoxy resins.

N-Isopropyl Hydroxylamine is used in the synthesis of specialty chemicals.
N-Isopropyl Hydroxylamine is used as an intermediate in the manufacture of surfactants.

N-Isopropyl Hydroxylamine is used in the production of adhesives and sealants.
N-Isopropyl Hydroxylamine is used as a curing agent in the production of composites.

N-Isopropyl Hydroxylamine is used in the manufacture of flavor and fragrance compounds.
N-Isopropyl Hydroxylamine is used as a chelating agent in the production of detergents.
N-Isopropyl Hydroxylamine is used in the synthesis of biologically active compounds.

N-Isopropyl Hydroxylamine is used in the production of ion exchange resins.
N-Isopropyl Hydroxylamine is used in the manufacture of lubricants and fuels.

N-Isopropyl Hydroxylamine is commonly used as a reducing agent in organic chemistry reactions.
N-Isopropyl Hydroxylamine is used as an oxygen scavenger in boiler water treatment.
N-Isopropyl Hydroxylamine is used as an intermediate in the production of pharmaceuticals.

N-Isopropyl Hydroxylamine can be used to reduce nitro compounds to amines.
N-Isopropyl Hydroxylamine is used as a polymerization inhibitor in the production of monomers.
N-Isopropyl Hydroxylamine is used in the synthesis of hydroxylamine derivatives.

N-Isopropyl Hydroxylamine is used as an antioxidant in the production of plastics and rubber.
N-Isopropyl Hydroxylamine is used as an intermediate in the production of agrochemicals.

N-Isopropyl Hydroxylamine can be used to synthesize oximes from carbonyl compounds.
N-Isopropyl Hydroxylamine is used in the synthesis of organosilicon compounds.

N-Isopropyl Hydroxylamine is used as a reducing agent in the preparation of metal nanoparticles.
N-Isopropyl Hydroxylamine is used as a stabilizer in the production of emulsion polymers.

N-Isopropyl Hydroxylamine is used in the manufacture of paper and pulp products.
N-Isopropyl Hydroxylamine can be used as a precursor to synthesize amides from carboxylic acids.

N-Isopropyl Hydroxylamine is used in the production of detergents and surfactants.
N-Isopropyl Hydroxylamine is used as a stabilizer in the production of polyurethane foams.
N-Isopropyl Hydroxylamine can be used to reduce aromatic nitro compounds to amino compounds.

N-Isopropyl Hydroxylamine is used as a reducing agent in the synthesis of heterocyclic compounds.
N-Isopropyl Hydroxylamine is used in the manufacture of coatings and paints.

N-Isopropyl Hydroxylamine is used as a stabilizer in the production of vinyl acetate polymers.
N-Isopropyl Hydroxylamine can be used to reduce aldehydes and ketones to alcohols.

N-Isopropyl Hydroxylamine is used in the synthesis of chiral compounds.
N-Isopropyl Hydroxylamine is used as a reducing agent in the preparation of carboxylic acids.

N-Isopropyl Hydroxylamine is used in the production of synthetic fibers.
N-Isopropyl Hydroxylamine is used as a stabilizer in the production of synthetic resins.

DESCRIPTION

N-Isopropyl Hydroxylamine is a chemical compound with the molecular formula C3H9NO, and its IUPAC name is N-(propan-2-yl)oxime.
N-Isopropyl Hydroxylamine is an organic compound with the chemical formula (CH3)2CHNH(OH).

N-Isopropyl Hydroxylamine is a colorless to light yellow liquid with a characteristic odor.
N-Isopropyl Hydroxylamine is soluble in water, alcohol, and ether.
N-Isopropyl Hydroxylamine is a weak base and reacts with acids to form salts.

N-Isopropyl Hydroxylamine is used as a reducing agent in various chemical reactions.
N-Isopropyl Hydroxylamine is commonly used in the synthesis of pharmaceuticals and agrochemicals.

N-Isopropyl Hydroxylamine can also be used as a polymerization inhibitor.
N-Isopropyl Hydroxylamine is often used in the preparation of nitrones, which are important intermediates in organic synthesis.

N-Isopropyl Hydroxylamine is a useful reagent for the preparation of oximes from carbonyl compounds.
N-Isopropyl Hydroxylamine can also be used to prepare hydroxamic acids from esters and amides.

N-Isopropyl Hydroxylamine has been shown to be an effective corrosion inhibitor in acidic media.
N-Isopropyl Hydroxylamine can be used to prevent corrosion of steel and other metals.
N-Isopropyl Hydroxylamine has been investigated as a potential antitumor agent.

N-Isopropyl Hydroxylamine has been found to be effective against certain types of cancer cells.
N-Isopropyl Hydroxylamine has also been investigated as a potential treatment for Alzheimer's disease.

N-Isopropyl Hydroxylamine has been shown to inhibit the formation of beta-amyloid fibrils, which are a hallmark of Alzheimer's disease.
N-Isopropyl Hydroxylamine has also been investigated as a potential treatment for Parkinson's disease.

N-Isopropyl Hydroxylamine has been found to protect dopaminergic neurons from oxidative stress.
N-Isopropyl Hydroxylamine has been used in the production of surfactants and other specialty chemicals.
N-Isopropyl Hydroxylamine is a versatile compound with a wide range of applications in various fields of chemistry.

PROPERTIES

Chemical formula: C3H9NO
Molecular weight: 75.11 g/mol
Appearance: Colorless to light yellow liquid
Odor: Ammonia-like odor
Melting point: -30 °C (-22 °F; 243 K)
Boiling point: 82-83 °C (180-181 °F; 355-356 K)
Density: 0.90 g/cm3
Solubility: Soluble in water, ethanol, and diethyl ether
Flash point: 16 °C (61 °F; 289 K)
Autoignition temperature: 400 °C (752 °F; 673 K)
Vapor pressure: 78.4 hPa (20 °C)
Refractive index: 1.4175 (20 °C)
Viscosity: 0.5 mPa·s (20 °C)
pH: 6-8 (10% aqueous solution)
Explosive limits: 1.3%-9.5% (in air)
Stability: Stable under normal conditions
Hazard identification: Flammable liquid and vapor, may be harmful if inhaled, swallowed, or absorbed through the skin
Molecular structure: Consists of an isopropyl group (-CH(CH3)2) attached to a hydroxylamine group (-NH2OH) via an N atom
Reactivity: Reacts with strong oxidizing agents, strong acids, and metals
Storage: Store in a cool, dry, well-ventilated area, away from heat, sparks, flames, and incompatible materials
Handling: Use personal protective equipment, such as gloves and goggles, when handling N-Isopropyl Hydroxylamine, and avoid skin contact and inhalation of vapors
Incompatibility: Incompatible with strong oxidizing agents, strong acids, and metals
Corrosivity: Non-corrosive to metals and tissues
Biodegradability: Readily biodegradable under aerobic conditions
Ecotoxicity: Low toxicity to aquatic organisms
Waste disposal: Dispose of N-Isopropyl Hydroxylamine and its solutions in accordance with local regulations and approved procedures.

FIRST AID

If N-Isopropyl Hydroxylamine comes into contact with the eyes, skin, or is inhaled or ingested, immediate first aid measures should be taken.
Here are some general guidelines:

Eye contact:

Rinse the eyes thoroughly with water for at least 15 minutes, lifting the upper and lower lids occasionally.
Seek medical attention if irritation persists.

Skin contact:

Remove any contaminated clothing and wash the affected skin with soap and water.
Seek medical attention if irritation or rash develops.

Inhalation:

Move the affected person to fresh air immediately.
If the person is having difficulty breathing, seek medical attention immediately.

Ingestion:

If ingested, do not induce vomiting.
Rinse the mouth with water and seek medical attention immediately.

If N-Isopropyl Hydroxylamine is spilled, contain the spill and prevent it from spreading.
Clean up the spill with absorbent materials and dispose of them properly.
Wear protective clothing and gloves when handling N-Isopropyl Hydroxylamine.

Store N-Isopropyl Hydroxylamine in a cool, dry, well-ventilated area away from incompatible materials.
Always follow proper safety procedures when handling N-Isopropyl Hydroxylamine.

HANDLING AND STORAGE

N-Isopropyl Hydroxylamine should be stored in a cool, dry, and well-ventilated area.
Keep the container tightly closed when not in use.
N-Isopropyl Hydroxylamine should be stored away from sources of heat, ignition, and strong oxidizing agents.

The storage area should be free from incompatible materials and substances.
Store N-Isopropyl Hydroxylamine in a fire-resistant storage area.

Keep away from children and pets.
Avoid skin contact, inhalation, or ingestion of N-Isopropyl Hydroxylamine.
Wear appropriate personal protective equipment when handling N-Isopropyl Hydroxylamine, including gloves, safety glasses, and a lab coat.

Do not eat, drink, or smoke when working with N-Isopropyl Hydroxylamine.
Do not allow N-Isopropyl Hydroxylamine to come into contact with water.

Store N-Isopropyl Hydroxylamine in a container made of a compatible material, such as glass or stainless steel.
Label all containers of N-Isopropyl Hydroxylamine with the appropriate hazard warning and safety information.

Avoid storing N-Isopropyl Hydroxylamine near food, feed, or pharmaceuticals.
Do not reuse containers that previously held N-Isopropyl Hydroxylamine without proper cleaning and decontamination.

Ensure that the storage area for N-Isopropyl Hydroxylamine is equipped with appropriate fire suppression and emergency response equipment.
Store N-Isopropyl Hydroxylamine away from direct sunlight and other sources of ultraviolet radiation.
Store N-Isopropyl Hydroxylamine away from acids, bases, and other incompatible materials.

Do not store N-Isopropyl Hydroxylamine in poorly ventilated areas.
Ensure that the storage area for N-Isopropyl Hydroxylamine is well-marked and clearly labeled.
Store N-Isopropyl Hydroxylamine in a way that prevents accidental spills or leaks.

SYNONYMS

N-Isoxylhydroxylamine
N-Isopropylhydroxylamine
NIPH
IPHA
Isopropylhydroxylamine
2-Hydroxy-2-methylpropylamine
Isopropyl 2-hydroxy-2-methylpropylamine
2-Hydroxy-2-methylpropyl-N-hydroxylamine
2-(Hydroxy)-2-methyl-1-propanamine-N-oxide
N-Isopropyl-2-hydroxy-2-methylpropylamine
N-(1-Methylethyl)-2-(hydroxy)-2-methylpropylamine
2-Methyl-2-(hydroxy)-1-propylamine
NSC 5352
BRN 1745973
AC1L1TE2
AI3-52221
18924-01-1
IPA-HA
N-isopropylhydroxylamine
N-Isopropylhydroxylamin
Isopropylhydroxylamine
N-Isopropylhydroxylamine
2-Hydroxy-2-methylpropan-N-amine
Isonitroso-2-propanol
N-Isopropoxyamine
2-Amino-2-methylpropanol oxime
Hydroxyamine, N-isopropyl-
Isopropyl-N-hydroxyamine
N-hydroxyisopropylamine
N-Isopropylhydroxyammonium
N-(1-Methylethyl)hydroxylamine
2-Hydroxy-2-methylpropylamine N-oxide
N-Isopropylhydroxylammonium
2-Amino-2-methyl-1-propanol N-oxide
N-Isopropylhydroxyaminium
N-Isopropyl-2-hydroxy-2-methylpropanamine
Hydroxylamine, N-(1-methylethyl)-
2-Hydroxy-2-methylpropan-1-aminium
N-Isopropylhydroxyamine hydrochloride
N-isopropyl-N-hydroxy-amine
Hydroxyamine, isopropyl-
2-Amino-2-methyl-1-propanol N,N-dimethyl-N-oxide.

NIACIN, N° CAS : 59-67-6 - Niacine (Vitamine B3).acide nicotinique; CAS : 59-67-6; Synonymes : nicotinic acid;3-Pyridinecarboxylic acid;3-Carboxypyridine;Pyridine-beta-carboxylic;Niacin;3-CARBOXYLPYRIDINE;Acide nicotinique;ACIDUM NICOTINICUM;AKOTIN;Anti-pellagra vitamin;ANTIPELLAGRA VITAMIN;APELAGRIN;BIONIC;DASKIL;DAVITAMON PP;DIREKTAN;EFACIN;Kyselina nikotinova;LINIC;NAH, NAOTIN; Niacin; Niacinamide;Niaspan;NICACID;NICAGIN;NICAMIN;NICANGIN;Nico-400;NICO-SPAN;Nicobid;Nicocap;NICOCIDIN NICOCRISINA;NICODAN;NICODELMINE;NICODON;NICOLAR;NICONACID;NICONAT;NICONAZID;NICOROL;NICOSAN 3;NICOSIDE;NICOSYL;NICOTAMIN;NICOTENE;Nicotil;NICOTINE ACID;nicotinic acid;NICOTINIPCA;Nicotinoylhydrazine; Nicotinsaure; Nicovasan;Nicovasen;NICYL;Nipellen;NYCLIN;P.P. factor-pellagra preventive; factor; Pellagramin; PELLAGRIN; PELONIN; Peviton; PP FACTOR; Pyridine-3-carbonic acid; Pyridine-3-carboxylic acid; Pyridine-beta-carboxylic; PYRIDINE-BETA-CARBOXYLIC ACID;Pyridine-carboxylique-3; S115; SK-Niacin; SR 4390; VITAPLEX N; WAMPOCAP Nom INCI : NIACIN, Nom chimique : 3-Pyridinecarboxylic acid. N° EINECS/ELINCS : 200-441-0. Additif alimentaire : E375. Ses fonctions (INCI); Antistatique : Réduit l'électricité statique en neutralisant la charge électrique sur une surface. Agent lissant : Diminue la rugosité ou les irrégularités pour rendre la peau uniforme. Noms français : 3-CARBOXYLPYRIDINE; 3-CARBOXYPYRIDINE; 3-PYRIDINECARBOXYLIC ACID; ACIDE NICOTINIQUE; ACIDE PYRIDINECARBOXYLIQUE-3; NICOTINE ACID; NICOTINIC ACID; PYRIDINE-3-CARBONIC ACID; PYRIDINE-3-CARBOXYLIC ACID; PYRIDINE-BETA-CARBOXYLIC ACID. Utilisation et sources d'émission: Médicament

Niacin; 3-Pyridinecarboxylic acid; Nicotinic acid; Nicotinipca; Pyridin-carboxylic acid; Vitamin B; 3-Carboxylpyridine; 3-Carboxypyridine; anti-Pellagra vitamin; Acidum nicotinicum; Nicotine acid; Pyridine-3-carbonic acid; Pyridine-3-carboxylic acid; Kyselina nikotinova; Nicotinoylhydrazine; Nicotinsaure; Pyridine-carboxylique-3; M-pyridinecarboxylic Acid; Acide Nicotinique; Pyridine-carboxylique-3 cas no: 59-67-6

Nickel Carbonate; Nickel(II) carbonate (1:1); Nickel monocarbonate; nickelous carbonate; carbonic acid nickel salt; C.I. 77779; cas no: 3333-67-3

SYNONYMS Nickel(II) carbonate (1:1); Nickel monocarbonate; nickelous carbonate; carbonic acid nickel salt; C.I. 77779; AS CO. 3333-67-3

Nickel Sulfate; Nickel(II)Sulfate Hexahydrate; Nickelous sulfate, 6-hydrate; Sulfuric Acid, Nickel (2+) Salt, Hexahydrate; Nickel Monosulfate Hexahydrate; Blue Salt; Single Nickel Salt; Nickelsulfat (German); Sulfato de níquel (Spanish); Sulfate de nickel cas no: 7786-81-4

Synonyms: L-Isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L-methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto-D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl-L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl-L-lysine cyclic (3->7),(8->11),(13->19),(23->26),(25->28)-pentakis(sulfide);NISIN;nsc-112903;Nisin Ready Made Solution;Streptococcus element (element);Nisin from Lactococcus lactis Vetec(TM) reagent grade, 2.5% (balance sodium chloride and denatured milk solids);Nisin from Lactococcus lactis;NISINSTREPTOCOCCUS LACTIS CAS: 1414-45-5

Nickel sponge; nickel element cas no:7440-02-0

Ethylparaben. Nipagin® A is a water-soluble preservative. It offers broad spectrum of activity against bacteria and fungi. It is a short-chain paraben for higher water solubility. It exhibits low order of toxicity and effectiveness at low concentrations. It has stability over a broad pH-range and global acceptance in personal care applications. Nipagin® A shows good biodegradability at environmental concentrations. It is used in syndets & bar soaps, shampoos & showers products, liquid soaps, wet wipes, hair conditioners, antiperspirants & deodorants, hair styling products, creams, lotions and decorative cosmetics.Nipagin™ A is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals. it is suitable for both rinse-off and leave-on formulations. This product is supplied as a white, or almost white crystalline powder.Almost odourless, small, colourless crystals or a white, crystalline powder.Small, colorless crystals or powder at room temperature.Crystals from dilute alcohol.Nipagin A is a broad spectrum antimicrobial agent de signed for preservation of a wide range of cosmetics,toiletries and topical pharmaceuticals. Nipagin A is suitable to preserve both rinse- off and leave- on formu lations.Typical use concentrations of Nipagin A is 0.1 – 0.3 %. Combinations of p- Hydroxybenzoic acid esters, e.g. with Nipasol M, Nipagin M or Nipabutyl exhibit in creased activity compared with individual esters.Nipagin A is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in water. The low aqueous solubility does not affect the microbi ological efficacy of the esters. Most formulations requiring preservation contain a significant amount of water. This may mean that Nipagin A cannot readily be added directly to the formulation. Other methods of incorporation are quite straightfor ward however, and are listed below.The solubility of Nipagin A increases greatly as the temperature of the water rises. Therefore a concentrate may be made up by heating an appropriate quantity of water to 60- 100 °C prior to addition of Nipagin A. This concentrate may then be added to the formulation, pro vided that the ester concentration does not exceed its solubility in the formulation at normal ambient tem peratures. Nipagin A is readily soluble in polar organic solvents. Where such a solvent is already part of a formulation an Nipagin A concentrate may be made up prior to addi tion. If a suitable solvent is not already part of thefor mulation, a highly concentrated solution may be made up e.g. 32 % in Ethanol, which would give insignificant residual levels of ethanol in the end product. Nipagin A is readily soluble in lipophilic ingredients and may be introduced to a formulation by adding to the oil phase with some warming before any emulsifica tion stage. In multiphase systems, such as emulsions, it is often advisable to use a combination of aqueous dis solution with either of the other methods to ensure ade quate preservation. The ester may be incorporated in the water to its maximum solubility and any further quanti ties may be dissolved in the oil phase, or solvent, as appropriate. Nipagin A remains fully stable over a wide pH range from 4- 8. In general the lower the pH of the formula tion, the more active is Nipagin A. That can result in a lower use concentration when the pH of the formulation is more acidic. Nipagin A is a short-chain paraben for higher water solubility. Benefits Broad spectrum of activity against bacteria and fungi Low order of toxicity Effectiveness at low concentrations Stability over a broad pH-range Water-soluble Biodegradability at environmental concentrations Global acceptance in personal care applications Chemical name Ethyl 4-Hydroxybenzoate INCI designation Ethylparaben Product properties *) Appearance (20°C): White, or almost white crystalline powder. Chemical and physical data Melting point: 115 - 118 oC Assayacc. BP/PH.Eur: 98.0 - 102.0 % IUPAC name Ethyl 4-hydroxybenzoate Other names Ethyl paraben; Ethyl parahydroxybenzoate; Ethyl para-hydroxybenzoate; Ethyl p-hydroxybenzoate; 4-Hydroxybenzoic acid ethyl ester Identifiers CAS Number: 120-47-8 Ethylparaben is an ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol, It has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen. It is a paraben and an ethyl ester. Antimicrobial Preservative Used in Cosmetics and Personal Care. Uses Nipagin A is a broad spectrum antimicrobial agent designedfor preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals.Nipagin A is suitable to preserve both rinse- off and leave- on formulations. Applications Typical use concentrations of Nipagin A is 0.1 – 0.3 %.Combinations of p- Hydroxybenzoic acid esters, e.g. with Nipasol M, Nipagin M or Nipabutyl exhibit increased activity compared with individual esters. Incorporation Nipagin A is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in water.The low aqueous solubility does not affect the microbiological efficacy of the esters.Most formulations requiring preservation contain a significant amount of water.This may mean that Nipagin A cannot readily be added directly to the formulation.Other methods of incorporation are quite straightforward however, and are listed below.Ethylparaben (ethyl para-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid. Its formula is HO-C6H4-CO-O-CH2CH3. It is a member of the class of compounds known as parabens.It is used as an antifungal preservative. As a food additive, it has E number E214.Sodium ethyl para-hydroxybenzoate, the sodium salt of ethylparaben, has the same uses and is given the E number E215. Dissolving in water The solubility of Nipagin A increases greatly as the temperature of the water rises. Therefore a concentrate may be made up by heating an appropriate quantity of water to 60- 100 °C prior to addition of Nipagin A. This concentrate may then be added to the formulation, provided that the ester concentration does not exceed its solubility in the formulation at normal ambient temperatures. Dissolving in organic solvents Nipagin A is readily soluble in polar organic solvents. Where such a solvent is already part of a formulation an Nipagin A concentrate may be made up prior to addition. If a suitable solvent is not already part of the formulation,a highly concentrated solution may be madeup e.g. 32 % in Ethanol, which would give insignificant residual levels of ethanol in the end product. Solubilisation in oils, emulsifiers etc. Nipagin A is readily soluble in lipophilic ingredients and may be introduced to a formulation by adding to the oil phase with some warming before any emulsification stage. In multiphase systems, such as emulsions, it is often advisable to use a combination of aqueous dissolution with either of the other methods to ensure adequate preservation. The ester may be incorporated in the water to its maximum solubility and any further quantities may be dissolved in the oil phase, or solvent, as appropriate. pH stability Nipagin A remains fully stable over a wide pH range from 4- 8. In general the lower the pH of the formulation, the more active is Nipagin A. That can result in a lower use concentration when the pH of the formulation is more acidic. Temperature stability Nipagin A is stable up to 80 °C Solubility The solubility of Nipagin A in different solvents is illustrated in the following table. Solvent % (w/w) Water 10 °C 0.06 Water 25 °C 0.11 Water 80 °C 0.86 Water 100 °C 1.7 Acetone 46 Methanol 45 Ethanol 41 Propylene Glycol 20 Glycerol 0.5 Vegetable oils (arachis) 1.0 Liquid paraffin 0.025 Microbial Activity Nipagin A exhibits microbiostatic activity against a wide range of bacteria, yeast and mould. This is illustrated by the following table which shows the minimum inhibitory concentration (MIC) of Nipagin A against examples of different groups of microorganisms. Microorganisms MIC level (%) Gram Negative Bacteria Pseudomonas aeruginosa 0.10 Escherichia coli 0.05 Klebsiella aerogenes 0.05 Klebsiella pneumoniae 0.05 Serratia marcescens 0.05 Proteus vulgaris 0.06 Salmonella enteritidis 0.05 Salmonella typhi 0.10 Microorganisms MIC level (%) Gram Positive Bacteria Stpahylococcus aureus 0.07 Streptococcus haemolyticus 0.06 Bacillus cereus 0.025 Bacillus subtilis 0.10 Lactobacillus buchneri 0.06 Yeasts Candida albicans 0.07 Saccharomyces cerevisiae 0.05 Molds Aspergillus niger 0.04 Penicillium digitatum 0.025 Rhizopus nigricans 0.025 Chemical Properties white crystalline powder Chemical Properties Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder. Uses An antimicrobial Uses bronchodilator, tocolytic Uses Preservative for pharmaceuticals. Production Methods Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%). Synthesis Reference(s) The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007 Pharmaceutical Applications Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations. It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives. The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline. Contact allergens This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin. Safety Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight. LD50 (mouse, IP): 0.52 g/kg LD50 (mouse, oral): 3.0 g/kg storage Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature). Ethylparaben should be stored in a well-closed container in a cool, dry place. Incompatibilities The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy. Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids. Regulatory Status Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Ethylparaben * A preservative found in skin care products, often used to treat dry skin through essential oils such as eucalyptus and primrose oil * Read the following TIA articles concerning ethylparaben and its link to cancer: Preservatives and Parabens and Are They Safe? and What Is It: Estrogen in my Shampoo Ethylparaben is a paraben and preservative found in many skin care products, ranging from skin cream to body lotion to deodorant. It can be found in essential oils used to treat dry skin and in primrose oil serving as an anti-septic. Although parabens are generally considered safe when used in low percentages (.04% - .08%), a study claimed to have found a link between parabens and breast cancer. According to the Cosmetic Ingredient Review (CIR) Expert Panel, however, "the available acute, subchronic, and chronic toxicity tests, using a range of exposure routes, demonstrate a low order of parabens' toxicity at concentrations that would be used in cosmetics" (source). After testing different levels of exposure to parabens in women, men, and children, the CIR Expert Panel found that these "determinations are conservative and likely represent an overestimate of the possibility of an adverse effect (e.g., use concentrations may be lower, penetration may be less) and support the safety of cosmetic products in which parabens preservatives are used." * A preservative found in skin care products, often used to treat dry skin through essential oils such as eucalyptus and primrose oil * Read the following TIA articles concerning ethylparaben and its link to cancer: Preservatives and Parabens and Are They Safe? and What Is It: Estrogen in my Shampoo Functions: Ethylparaben is a paraben and preservative found in many skin care products, ranging from skin cream to body lotion to deodorant. It can be found in essential oils used to treat dry skin and in primrose oil serving as an anti-septic. Although parabens are generally considered safe when used in low percentages (.04% - .08%), a study claimed to have found a link between parabens and breast cancer. According to the Cosmetic Ingredient Review (CIR) Expert Panel, however, "the available acute, subchronic, and chronic toxicity tests, using a range of exposure routes, demonstrate a low order of parabens' toxicity at concentrations that would be used in cosmetics" (source). After testing different levels of exposure to parabens in women, men, and children, the CIR Expert Panel found that these "determinations are conservative and likely represent an overestimate of the possibility of an adverse effect (e.g., use concentrations may be lower, penetration may be less) and support the safety of cosmetic products in which parabens preservatives are used." Ultimately, the cosmetics industry has found the low levels of parabens in cosmetics to be safe and the connection between parabens and breast cancer to be weak. The FDA finds that although parabens can mimic estrogen, the actual effects of this low level of activity on the body do not cause cancer in a higher incidence than naturally occurring estrogen. Nonetheless, many paraben-free products are being created to avoid the possible dangers of ethylparaben and other paraben-based preservatives. Roles Classification Biological Role(s): antimicrobial food preservative A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. phytoestrogen Any compound produced by a plant that happens to have estrogenic activity. Application(s): antimicrobial food preservative A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). Ethylparaben provides the good performance against Gram positive bacteria exhibited by all the parabens and has the same limitations regarding pH range (acidic only), system compatibility (avoid high levels of ethoxylates) and water solubility (limited). Ethylparaben has been used in combination with Propylparaben in oral preparations for controlling fermentative action. It can be used alone, but is generally used at 0.10 to 0.25% levels with other CoSepts as the antifungal portion of the preservative system. Use: Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives and antiseptic for bacteria. Use: Preservative, Cosmetics, Feed, Pharmaceutical, Soft Drink, Alcohol Beverage, Beverage Powder, Fruit Juice, Puddings, Sauces, Baking Food, Sauage, Flavoring Agent. Other names: Benzoic acid, 4-hydroxy-, ethyl ester; Benzoic acid, p-hydroxy-, ethyl ester; p-Carbethoxyphenol; p-Hydroxybenzoate ethyl ester; p-Hydroxybenzoic acid ethyl ester; Aseptoform E; Bonomold OE; Easeptol; Ethyl p-hydroxybenzoate; Ethyl parasept; Ethyl Butex; Ethyl 4-hydroxybenzoate; Mycocten; Napagin A; Nipagin A; Nipazin A; Sobrol A; Solbrol A; Tegosept E; 4-Hydroxybenzoic acid, ethyl ester; Ethyl para-hydroxybenzoate; Ester etylowykwasu p-hydroksybenzoesowego; Ethylester kyseliny p-hydroxybenzoove; Ethyl p-oxybenzoate; Nipagina A; p-Oxybenzoesaeureaethylester; 4-(Ethoxycarbonyl)phenol; 4-Carbethoxyphenol; Aseptin A; Aseptine A; Para-hydroxybenzoic acid ethyl ester; Mekkings E; NSC 23514 Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive Storage instructions The product must be stored in tighly closed container in a cool, well- ventilated, dry place. Further information on handling, storage and dispatch isgiven in the EC safety data sheet.

SILVER NITRATE, N° CAS : 7761-88-8 - Nitrate d'argent. Nom INCI : SILVER NITRATE. Nom chimique : Silver nitrate. N° EINECS/ELINCS : 231-853-9. Classification : Règlementé, Colorant capillaire. Ses fonctions (INCI). Agent colorant pour cheveux : Colore les cheveux. Noms français : Nitrate d'argent. Noms anglais : LUNAR CAUSTIC; NITRIC ACID SILVER(1+) SALT; SILVER MONONITRATE; Silver nitrate; SILVER(1+) NITRATE. Utilisation: Le nitrate d'argent trouve plusieurs applications, notamment: en photographie, dans la manufacture de miroirs, dans les encres indélébiles, en teinture de cheveux, comme antiseptique, en chromatographie, comme agent titrimétrique en chimie analytique. Argenti nitras; Argerol, gümüş nitrat, Lunar caustic, Nitric acid , silver(1+) salt (1:1), Nitric acid silver(I) salt, Nitric acid, silver(1+) salt, Silver mononitrate, Silver nitrate(DOT), Silver(1+) nitrate, Silver(I) nitrate (1:1), Azotan srebra (pl), azotan(V) srebra (pl) ; azotat de argint (ro); dusičnan strieborný (sk); dusičnan stříbrný (cs); ezüst-nitrát (hu); Ezüstnitrát (hu); Hopeanitraatti (fi); Hõbenitraat (et); Nitrat de argint (ro); Nitrat tal-fidda (mt); Nitrate d'argent (fr); Nitrato d'argento (it); Nitrato de plata (es); Nitrato de prata (pt); nitrato di argento (it); Sidabro nitratas (lt); Silbernitrat (de); Silver nitrate (no); Silvernitrat (sv); Srebrov nitrat (hr); Sudraba nitrāts (lv); sølvnitrat (da); Zilvernitraat (nl); Νιτρικός άργυρος (el); Сребърен нитрат (bg). gümüş nitrat, gümüşnitrat, : Silver Nitrate; Nitric acid silver(I) salt, Argenti nitras ;Silver nitrate concentrate; silver(1+) ion nitrate; silver(1+) ion nitrooxidane; Silver(I) nitrate; silver(I)nitrate; silver;nitrate; identifiers231-853-9 [EINECS]; 7761-88-8 [RN]; Argenti nitras [Latin]; Argenti nitras; Lunar caustic; MFCD00003414 ; [MDL number]; Nitrate d'argent [French]; Nitrate d'argent(1+) [French] [ACD/IUPAC Name]; Nitrato de plata [Spanish]; Nitric acid silver (1+) salt; nitric acid silver(I) salt; Nitric acid, silver(1+) salt ;Silber(1+)nitrat [German]; Silver nitrate ; Silver(1+) nitrate [ACD/IUPAC Name]; silver(i) nitrate; Silver(I) nitrate (1:1); Argerol; Nitric acid silver(1+) salt; Silbernitrat; silver mononitrate; Silver nitrate ACS grade; 硝酸银 [Chinese]

farin; amidon ;starch food; sorghum gum; starch; potato starch cas no:9005-25-8

nitric acid; Aqua Fortis; Azotic Acid; Hydrogen nitrate; nitrous fumes; Acid Nitrique, Acido Nitroco, Acido Nitrico, Aqua Fortis, Azotic Acid, Azotowy Kwas, Engraver's Acid, Hydrogen Nitrate, Kyselina Dusicne, Nital, Nitrous Fumes, Nitryl Hydroxide, Salpetersaure, Salpeterzuuroplossingen cas no: 7697-37-2

Mononitromethane; Nitrocarbol; NM; Nitrometan (Polish); NMT; nitrometano (Spanish); Nitrométhane (French) CAS NO:75-52-5

In-can biocide for comprehensive wet state protection of household products. Formaldehyde free product. Blend of 5-chloro-2- methyl-4-isothiazolin-3- one and 2-methyl-4- isothiazolin-3-one (3:1) ; 55965-84-9 ; Liquid; 1,5%

In-can biocide for comprehensive wet state protection of household products. Provides headspace protection. Good pH and temperature stability. 1,6-dihydroxy-2,5- dioxahexane 3586-55-8 Liquid 100%

Mononitromethane; Nitrocarbol; NM; Nitrometan (Polish); NMT; nitrometano (Spanish); Nitrométhane (French) CAS NO:75-52-5

N-Lauroylsarcosine sodium salt is a white Powder.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.

CAS Number: 137-16-6
EC Number: 205-281-5
MDL number: MFCD00042728
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Molecular Formula: C₁₅H₂₈NNaO₃

N-Lauroylsarcosine sodium salt also decreases transcription efficiency.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.
N-Lauroylsarcosine sodium salt is a white Powder

N-Lauroylsarcosine sodium salt is a sodium salt of an acyl derivative of sarcosine, which is a natural amino acid found in muscles and other body tissues.
Acyl sarcosines are considered modifiŽed fatty acids in which the hydrocarbon chains are interrupted by an amidomethyl group in the alpha position.
They are used as hair-conditioning agents and surfactant-cleansing agents in cosmetics, as well as to improve wetting and penetration of topical pharmaceutical products.

Acyl sarcosines and their sodium salts are also used in the metal finishing and processing industries for their crystal modifying, anti-rust, and anti-corrosion properties.
N-Lauroylsarcosine sodium salt is an amino acid surfactant.

A powerful anionic surfactant, N-Lauroylsarcosine sodium salt, that confers mild detergency, excellent foaming and lathering characteristics.
N-Lauroylsarcosine sodium salt displays synergy with other detergents.
N-Lauroylsarcosine sodium salt also decreases transcription efficiency.

N-Lauroylsarcosine sodium salt is an inhibitor of HXK.
N-Lauroylsarcosine sodium salt, also known as sarkosyl, is an ionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.

In molecular biology experiments, N-Lauroylsarcosine sodium salt is used to inhibit the initiation of DNA transcription.
N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH.

Addition of an mixture of equal parts of sodium lauroyl sarcosinate and the non-ionic surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone. Such aggregates can help carry other small molecules, such as drugs, through the skin.

N-Lauroylsarcosine sodium salt is a sodium salt that belongs to the group of sodium salts.
The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.

N-Lauroylsarcosine sodium salt has been shown to have biological properties such as permeability through human serum and biodegradability.
The salt form of N-Lauroylsarcosine sodium salt has an electrochemical impedance spectrum which can be used to identify it.
N-Lauroylsarcosine sodium salt is a Suggested storage of Sodium lauroyl sarcosinate: Store in tightly closed containers in a cool, dry, and well-ventilated area away from oxidizing agents and sources of ignition; ground all equip. containing this material 25 C

N-Lauroylsarcosine sodium salt is an anionic surfactant with an ability to denature proteins.
Due to its microbicidal property, N-Lauroylsarcosine sodium salt is being considered as a potent anti-microbicide in topical formulations, especially against sexually transmitted diseases (STDs).

N-Lauroylsarcosine sodium salt is non flammable.
N-Lauroylsarcosine sodium salt, also known as sarkosyl, is a white powder derived from sarcosine, which make it is fate-free and biodegradable.
N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.

N-Lauroylsarcosine sodium salt, the English name is SODIUMLAUROYLSARCOSINATE, alias: sodium lauroyl-N-methylaminoacetate, sodium dodecanoyl-N-methyl glycinate.
N-Lauroylsarcosine sodium salt is safe to use and generally has no effect on pregnant women.

N-Lauroylsarcosine sodium salt is a white powder.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.
N-Lauroylsarcosine sodium salt is an anionic detergent.

N-Lauroylsarcosine sodium salt, also known as sarkosyl, is an ionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.
N-Lauroylsarcosine sodium salt is an anionic surfactant which also has protein denaturant potency.

USES and APPLICATIONS of N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt is used as a detergent, foaming agent, and antienzyme for dentifrices.
N-Lauroylsarcosine sodium salt is permitted for use as an inert ingredient in non-food pesticide products.
N-Lauroylsarcosine sodium salt, also known as sarkosyl, is an ionic surfactant derived from sarcosine, used as a foaming and cleansing agent in shampoo, shaving foam and foam wash products.

In molecular biology experiments, N-Lauroylsarcosine sodium salt is used to inhibit the initiation of DNA transcription.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.
N-Lauroylsarcosine sodium salt is a high quality research product used as multipurpose anionic surfactant widely used in the biochemistry of protein extraction and purification.

N-Lauroylsarcosine sodium salt has been especially used with membrane proteins.
N-Lauroylsarcosine sodium salt is used multipurpose anionic surfactant widely used in the biochemistry of protein extraction and purification.
N-Lauroylsarcosine sodium salt has been especially used with membrane proteins.

N-Lauroylsarcosine sodium salt (stabilised) is used for synthesis.
In addition to its excellent surface activity, N-Lauroylsarcosine sodium salt also has antibacterial and bactericidal properties, corrosion and rust resistance, and good biodegradability.

N-Lauroylsarcosine sodium salt is used Food and beverage, metal rust prevention, mineral flotation, pesticides and biomedicine and many other fields.
In terms of mineral flotation, N-Lauroylsarcosine sodium salt has a good synergy with cationic surfactants to achieve higher flotation efficiency, and is a new type of amino acid anionic surfactant.

N-Lauroylsarcosine sodium salt has the characteristics of washing, emulsifying, penetrating and solubilizing;
Excellent foamability, and the foam is delicate and long-lasting.
N-Lauroylsarcosine sodium salt is suitable as a raw material for toothpaste and cosmetic foam, shampoo, shaving cream;

N-Lauroylsarcosine sodium salt is used Foaming and cleansing agent for shampoos; mild to skin and hair.
N-Lauroylsarcosine sodium salt is used Wetting agent.
N-Lauroylsarcosine sodium salt is used enzyme inhibitor in oral care.

N-Lauroylsarcosine sodium salt is used Corrosion inhibitor.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.

N-Lauroylsarcosine sodium salt uses and applications include: Foam builderstabilizer, wetting agent, detergent, lubricant, antistat, corrosion inhibitor, bacteriostat, penetrant in dentals, pharmaceuticals, surgical scrubs, shampoos, depilatories, shaving preparations, food packaging, householdindustrial cleaners, froth flotation, textileleather processing, emulsion polymerization; antistat, surfactant, viscous control agent in cosmetics.

N-Lauroylsarcosine sodium salt is used anti-enzyme for dentifrices; in food packaging adhesives; and in vinylidene coatings for food-contact cellophane.
N-Lauroylsarcosine sodium salt is used Paint, ink additives, increase compatibility and stability.
N-Lauroylsarcosine sodium salt is used Corrosion inhibitor and rust remover in metal processing.

N-Lauroylsarcosine sodium salt is used in medicine as a solvent for cell purification.
N-Lauroylsarcosine sodium salt is an anionic surfactant, especially suitable for the preparation of shampoo, bath liquid, cleansing milk, baby detergent, tableware detergent and so on.

N-Lauroylsarcosine sodium salt is used in medicine as a solvent for cell purification.
N-Lauroylsarcosine sodium salt is a surfactant that is used in water treatment, wastewater treatment, and as a detergent.
N-Lauroylsarcosine sodium salt is also used as an analytical tool for the titration calorimetry of sodium salts.

N-Lauroylsarcosine sodium salt is personal care products as well as in household and industrial applications, and it is used as a co-surfactant in cleanser formulations such as shampoos and body washes.
N-Lauroylsarcosine sodium salt can also be used in oral care applications such as toothpastes and incorporated into syndet and combo bars.

The typical usage levels range of N-Lauroylsarcosine sodium salt from 1-5% on an active basis.
N-Lauroylsarcosine sodium salt is mild, biodegradable anionic surfactants derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products. N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.

N-Lauroylsarcosine sodium salt is a high foam, eco-friendly surfactant.
N-Lauroylsarcosine sodium salt has good chlorine stability with anti-corrosion properties.
N-Lauroylsarcosine sodium salt has excellent ocular tolerance and gentleness.

N-Lauroylsarcosine sodium salt is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent.
N-Lauroylsarcosine sodium salt has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged.

N-Lauroylsarcosine sodium salt also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away.
As a modified fatty acid, N-Lauroylsarcosine sodium salt is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.

N-Lauroylsarcosine sodium salt is used Detergent, foaming agent, and antienzyme for dentifrices.
N-Lauroylsarcosine sodium salt is suitable for solubilization and separation of membrane proteins, lysis of cells during the isolation of RNA, and inhibition of hexokinase.

N-Lauroylsarcosine sodium salt is mainly used in cosmetics and skincare products as an anti-static, foaming agent, detergent, and surfactant.
N-Lauroylsarcosine sodium salt is an amino acid surfactant with excellent surface activity, antibacterial and bactericidal properties, corrosion and rust inhibition and good biodegradability, etc.

N-Lauroylsarcosine sodium salt is therefore widely used in many fields such as detergents, cosmetics, food and beverage, metal rust prevention, mineral flotation, pesticides, and biological medicine.
N-Lauroylsarcosine sodium salt is used usage Biochemical research.

N-Lauroylsarcosine sodium salt is used anionic surfactants.
N-Lauroylsarcosine sodium salt is used hexokinase inhibitor.
N-Lauroylsarcosine sodium salt is used Anionic detergent.

N-Lauroylsarcosine sodium salt is used Separation of yeast ribonucleic acid.
N-Lauroylsarcosine sodium salt can be used for RNA and DNA isolation, as a lysing agent in cell purification, as an additive in the isolation of DNA from human serum, and to increase the nitrogen fixation capacity of legume rhizobia by adding this product, and has many applications in immunochemistry.

N-Lauroylsarcosine sodium salt can be used in RNA extraction protocols for cell lysis because it does not produce excessive foam.
N-Lauroylsarcosine sodium salt, also known as sarcosyl, is an anionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.

N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).

N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.
N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungistatic agent in aqueous dispersion (1%).
N-Lauroylsarcosine sodium salt is used Cell Lysis Reagent | Electrophoresis Chromatography | Detergents.

N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.

N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungistatic agent in aqueous dispersion (1%).
N-Lauroylsarcosine sodium salt, Ultrapure is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt has been used as one of the components of the lysing solution in the cornet assay.

N-Lauroylsarcosine sodium salt has been used for lysing protoplasts in the process of chromosomal DNA isolation form Streptococcus mutans.
In molecular biology experiments, N-Lauroylsarcosine sodium salt is used to inhibit the initiation of DNA transcription.
N-Lauroylsarcosine sodium salt is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.

Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH.
The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.

Addition of an mixture of equal parts of N-Lauroylsarcosine sodium salt and the non-ionic surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone.
Such aggregates can help carry other small molecules, such as drugs, through the skin.

Cosmetic Uses of N-Lauroylsarcosine sodium salt: antistatic agents, cleansing agents, foaming agents, hair conditioning, skin conditioning, surfactants, surfactant - emulsifying, and viscosity controlling agents.

BIOCHEM/PHYSIOL ACTIONS OF N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt is an anionic surfactant which also has protein denaturant potency.
In addition, N-Lauroylsarcosine sodium salt has been shown as a microbicide for sexually transmitted diseases.

IN CULTURE, N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt was sold as a special ingredient called "Gardol" in Colgate "Dental Cream", as toothpaste was then called, during the 1950s through the mid-1960s in the US and the mid-1970s in France.
N-Lauroylsarcosine sodium salt's current use as a preventive dentifrice is in Arm & Hammer Baking Soda Toothpaste, a Church & Dwight product, where it is used as a surfactant.

PHYSICAL and CHEMICAL PROPERTIES of N-LAUROYLSARCOSINE SODIUM SALT:
Molecular Formula: C₁₅H₂₈NNaO₃
Appearance: White to Off-White Solid
Melting Point:147-150°C
Molecular Weight: 293.38
Storage: 4°C
Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
Molecular Weight: 294.39
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 12
Exact Mass: 294.20451307
Monoisotopic Mass: 294.20451307
Topological Polar Surface Area: 57.6 Å²
Heavy Atom Count: 20
CAS ID: 137-16-6
Density: 1.14 g/cm3 (20 °C)
Flash point: 267 °C
Melting Point: 146 °C
pH value: 8 (30 g/l, H₂O, 20 °C)
Vapor pressure: 0.02 hPa (20 °C)
Bulk density: 400 kg/m3

IUPAC Name: sodium;2-[dodecanoyl(methyl)amino]acetate
Molecular Weight: 293.38 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 12
Exact Mass: 293.19668804 g/mol
Monoisotopic Mass: 293.19668804 g/mol
Topological Polar Surface Area: 60.4Å²
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 260
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
Molecular Formula: C15H28NNaO3
Molecular Weight: 293.3827693
SMILES: CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
CAS Min %: 94
CAS Max %: 100

Melting Point: 45.0°C to 47.0°C
Color: White
pH: 7.0 to 9.0
Loss on Drying: 7% max. ()
Infrared Spectrum: Authentic
Linear Formula: NaCO2CH2N(CH3)CO(CH2)10CH3
Merck Index: 154401
Solubility Information: (10% in water) Almost clear colorless to light yellow
Formula Weight: 293.39
Percent Purity: 95%
Physical Form: Solid
Chemical Name or Material: N-Lauroylsarcosine sodium salt
Formal Charge: 0
Complexity: 254
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
IUPAC Name: sodium2-[dodecanoyl(methyl)amino]acetate
Canonical SMILES: CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
InChI: InChI=1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)/q+1/p-1
InChI Key: KSAVQLQVUXSOCR-UHFFFAOYSA-M

Boiling Point: 100ºC
Melting Point: 140ºC
Flash Point: 94ºC (30%)
Purity: 95%
Density: 1.033 g/mL at 20 °C
Solubility: water, 6490 mg/L @ 25 °C (est)
Appearance: Clear liquid
pH: 7.0-8.5
Assay: ≥95.0%
Appearance: White crystalline powder
Volatility: ≤5.0%
Color: White
Melting Point: 44°C to 47°C
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Beilstein: 5322974
Merck Index: 14,4368
Solubility Information: Soluble in water (293g/L).
Sensitivity: Hygroscopic
Formula Weight: 293.38
Physical Form: Crystalline Powder
Beilstein Registry Number: 5322974
CAS #: 137-16-6
Critical Micelle Concentration: 14.57 mM at 30 °C(Lit.)

EC Number: 205-281-5
Extinction Coefficient: EM = 3 (280 nm)(Lit.)
Flash Point: 267 °C / 512.6 °F (lit.)
Format: Powder
Hazard Statements: H315-H318-H330
Molecular Formula: C15H28NO3 • Na
Molecular Weight: 293.4
pH: 7.5 - 8.5 (10% aqueous solution)
Purity: >95.5%
Safety Symbol: GHS05, GHS06
Solubility: Soluble in water (100 mg/mL - clear to slightly hazy, colorless solution).
Density: 1.033 g/mL at 20 °C
Boiling Point: 100ºC
Melting Point: 46 °C
Molecular Formula: C15H28NNaO3
Molecular Weight: 293.378
Exact Mass: 293.196686
PSA: 60.44000
LogP: 2.11560
Storage condition: room temp
Stability: Stable.
Water Solubility: H2O: 1 M at 20 °C, clear, colorless
Appearance Form: powder

Colour: white
Odour: No data available
Odour Threshold: No data available
pH: 7,0 - 9 at 293 g/l at 25 °C
Melting point/freezing point: 146,1 °C at 1.013 hPa
Initial boiling point and boiling range: 350 - 410 °C at 1.013 hPa
CAS NUMBER: 137-16-6
MOLECULAR FORMULA: C15H28NO3 • Na
MOLECULAR WEIGHT: 293.4
BEILSTEIN REGISTRY NUMBER: 5322974
EC NUMBER: 205-281-5
MDL NUMBER: MFCD00042728
Molecular Weight: 293.4
Molecular Formula: C15H28NO3Na
InChI: InChI=1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1
InChI Key: KSAVQLQVUXSOCR-UHFFFAOYSA-M
Melting Point: 46 °C
Flash Point: 267 °C
Density: 1.033 g/mL at 20 °C
Solubility: Ethanol: slightly soluble; Methanol: slightly soluble; PBS (pH 7.2): slightly soluble
Appearance: Solid
Complexity: 260
EC Number: 205-281-5

Exact Mass: 293.19668804
Formal Charge: 0
Hazard Statements: Xi,T
Heavy Atom Count: 20
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 0
Isomeric SMILES: CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
MDL Number: MFCD00042728
Monoisotopic Mass: 293.19668804
pH: 7.0-9.0 (1M in H₂O, 25 °C)
Rotatable Bond Count: 12
Safty Description: 22-24/25-36/37/39-27-26-45-38-37/39
Shipping: Room temperature
Stability: ≥2 years
Supplemental Hazard Statements: H315-H318-H330-H319-H332
Symbol: GHS05,GHS06,GHS07
Topological Polar Surface Area: 60.4 Å²
Flash point: 267 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapour pressure: 0,02 hPa at 20 °C
Vapour density: No data available
Relative density: 1,141 g/cm3 at 20 °C

Water solubility: 293 g/l at 20 °C - completely soluble
Melting point: 46 °C
Density: 1.033 g/mL at 20 °C
vapor pressure: 0.02 hPa (20 °C)
RTECS: MC0598960
Flash point: 267℃
storage temp.: room temp
solubility: H2O: 1 M at 20 °C, clear, colorless
form: Powder
Specific Gravity: 1.03 (20/4℃)
color: White
Odor: at 100.00?%. bland
PH: 7.0-9.0 (25℃, 1M in H2O)
Water Solubility: Soluble in water (293 g/L).
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.06
Merck: 14,4368
BRN: 5322974
Stability: Stable.
LogP: 0.37
UN Number: 2811
Formula Weight: 293.38
Physical Form: Crystal-Powder at 20°C
Percent Purity: ≥98.0% (N)

Color: White
Melting Point: 46°C
pH: 8.0 to 9.5 (50g/L H2O 25°C)
Chemical Name or Material: Sodium N-Lauroylsarcosinate
Molecular Formula / Molecular Weight: C15H28NNaO3 = 293.38
Physical State (20 deg.C): Solid
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Hygroscopic
CAS RN: 137-16-6
Reaxys Registry Number: 5322974
PubChem Substance ID: 87571989
Merck Index (14): 4368
MDL Number: MFCD00042728
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 46.00 °C. @ 760.00 mm Hg
Boiling Point: 413.00 to 414.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 399.00 °F. TCC ( 203.70 °C. ) (est)
logP (o/w): 4.328 (est)
Soluble in: water, 6490 mg/L @ 25 °C (est)

FIRST AID MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Description of first aid measures:
*General advice:
Consult a physician.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.

ACCIDENTAL RELEASE MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-LAUROYLSARCOSINE SODIUM SALT:
-Control parameters:
--Components with workplace control parameters:
-Exposure controls:
--Appropriate engineering controls:
Avoid contact with skin, eyes and clothing.
Wash hands before breaks and immediately after handling the product.
--Personal protective equipment:
*Eye/face protection:
Face shield and safety glasses.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.

HANDLING and STORAGE of N-LAUROYLSARCOSINE SODIUM SALT:
-Precautions for safe handling:
Ensure all equipment is electrically grounded before beginning transfer operations.
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
-Specific end use(s):
No other specific uses are stipulated

STABILITY and REACTIVITY of N-LAUROYLSARCOSINE SODIUM SALT:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.

SYNONYMS:
Sodium N-Lauroyl Sarcosinate
N-Lauroylsarcosine Sodium Salt
Sodium 2-(N-Methyldodecanamido)acetate
Sodium Lauroylsarcosinate
N-Dodecanoyl-N-methylglycine Sodium Salt
N-Dodecanoylsarcosine Sodium Salt
N-Lauroyl-N-methylglycine Sodium Salt
Lauroylsarcosine (sodium)
n-Lauroylsarcosine sodium salt hydrate
SCHEMBL23450
AKOS024386303
N-Lauroylsarcosine sodium salt, >=94%
2-[dodecanoyl(methyl)amino]ethanoic acid; sodium
2-[methyl(1-oxododecyl)amino]acetic acid; sodium
A807204
N-Lauroylsarcosine sodium salt, >=97.0% (HPLC)
N-Lauroylsarcosine sodium salt, BioXtra, >=97% (TLC)
N-Lauroylsarcosine sodium salt, SAJ first grade, >=96.0%
N-Lauroylsarcosine sodium salt, detergent for use in cell lysis
N-Lauroylsarcosine sodium salt, Vetec(TM) reagent grade, 94%
N-Lauroylsarcosine sodium salt solution, 20%, for molecular biology
Sodium lauroylsarcosinate, EuropePharmacopoeia (EP) Reference Standard
N-Lauroylsarcosine sodium salt solution, 30% aqueous solution, >=97.0% (HPLC)
N-Lauroylsarcosine sodium salt, BioUltra, for molecular biology, >=99.0% (HPLC)
N-Lauroylsarcosine sodium salt
Glycine, N-methyl-N- (1-oxododecyl)-, sodium salt
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
N-Dodecanoyl-N-methylglycine sodium salt
N-Methyl-N-(1-oxododecyl)glycine Sodium Salt
Sarcosine, N-lauroyl-, sodium salt
Sarcosyl
Sarcosyl NL
Sarkosyl NL
Sodium [dodecanoyl(methyl)amino]acetate
Sodium 2-(N-methyldodecanamido)acetate
SODIUM LAUROYL SARCOSINATE
Sodium lauroylsarcosinate
Sodium N-dodecanoyl-N-methylglycinate
SODIUM N-LAUROYL SARCOSINATE
Sodium N-lauroylsarcosinate
[137-16-6] [RN]
2-(N-methyldodecanoylamino)acetic acid, sodium salt
EINECS 205-281-5
Gardol
Gardol?
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Hamposyl L-30
Lauroylsarcosine sodium salt
Lauroylsarcosine, Sodium Salt - CAS 137-16-6 - Calbiochem
Maprosyl 30
Medialan LL-99
N-Dodecanoyl-N-methylglycine, sodium salt
N-Dodecanoyl-N-methylglycinesodium salt
N-Dodecanoylsarcosine Sodium Salt
N-LAUROYL-N-METHYLGLYCINE SODIUM SALT
N-Lauroylsarcosine sodium saltmissing
N-Lauroylsarcosine, sodium
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosinesodium salt
N-Lauryl sarcosine sodium salt
N-Methyl-N-(1-oxododecyl)glycine, sodium salt
Sarcosine, N-lauroyl-, sodium salt (8CI)
Sarcosyl, Sodium lauroylsarcosinate
Sarkosyl
sodium 2-(dodecanoyl-methylamino)acetate
sodium 2-(dodecanoyl-methyl-amino)acetate
sodium 2-(dodecanoyl-methyl-amino)ethanoate
sodium 2-(lauroyl-methyl-amino)acetate
sodium 2-(methyl-(1-oxododecyl)amino)acetate
Sodium lauroylsarcosine
Sodium N-Lauroylsarcosinate
N-Dodecanoylsarcosine Sodium Salt
N-Lauroylsarcosine Sodium Salt
SODIUM N-LAUROYLSARCOSINE
sodium[dodecanoyl(methyl)amino]acetate
Sarkosyl NL-97
Sodium N-Lauroyl Sarcosinate
N-Methyl-N-(1-oxododecyl) glycine sodium salt
N-Dodecanoyl-N-methylglycine sodium salt
Sarkosyl NL
N-Dodecanoylsarcosine Sodium Salt
N-Lauroylsarcosine Sodium Salt
Sodium N-Dodecanoylsarcosinate
Sodium N-Dodecanoyl-N-methyl-glycinate
Sarcosyl
Sodium N-Lauroyl Sarcosinate
Sarkosyl NL
Sarcosyl
Sarcosyl NL-30
Sodium N-Lauroylsarcosinate
Sodium N-Dodecanoylsarcosinate
N-Dodecanoylsarcosine Sodium Salt
137-16-6
Sodium lauroylsarcosinate
Sodium N-lauroylsarcosinate
N-Lauroylsarcosine sodium salt
Sarkosyl NL
Sodium lauroyl sarcosinate
Sarkosyl
Gardol
Medialan LL-99
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Sarcosyl NL
Maprosyl 30
Compound 105
Hamposyl L-30
Sarcosyl NL 30
Sarkosyl NL 30
Sarkosyl NL 35
Sarkosyl NL 97
Sarkosyl NL 100
Sodium lauroylsarcosine
MFCD00042728
Sodium N-dodecanoyl-N-methylglycinate
Sodium N-lauroylsarcosine
N-Lauroylsarcosine, sodium
Lauroylsarcosine sodium salt
sodium lauroyl sarcosine
N-Lauroylsarcosine, sodium salt
n-lauryl sarcosine sodium salt
Lauroylsarcosine (sodium)
DTXSID0027066
N-Dodecanoyl-N-methylglycine, sodium salt
sodium 2-(N-methyldodecanamido)acetate
sodium [dodecanoyl(methyl)amino]acetate
632GS99618
Sarcosine, N-lauroyl-, sodium salt
Sodium N-Dodecanoylsarcosinate
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
N-Dodecanoylsarcosine Sodium Salt
Caswell No. 778B
Lauroylsarcosine (sodium salt)
NSC-117874
SODIUM N-LAUROYL SARCOSINATE
EINECS 205-281-5
EPA Pesticide Chemical Code 000174
NSC 117874
N-Dodecanoyl-N-methylglycine sodium salt
UNII-632GS99618
starbld0009501
GARDOL [MI]
MEDIALAN LL-33
N-Lauroylsarcosine-S-salt
EC 205-281-5
N-Methyl-N-(1-oxododecyl)glycine, sodium salt
SCHEMBL23451
Lauroylsarcosine, Sodium Salt
DTXCID907066
N-Methyl-N-(1-oxododecyl)glycine sodium salt (1:1)
CHEMBL1903482
KSAVQLQVUXSOCR-UHFFFAOYSA-M
SODIUM LAUROYL SARCOSINE 1KG
Tox21_202996
AKOS015901704
SODIUM LAUROYL SARCOSINATE [II]
NCGC00164323-01
NCGC00260541-01
SODIUM LAUROYL SARCOSINATE [INCI]
AS-81025
CAS-137-16-6
SODIUM LAUROYL SARCOSINATE [VANDF]
sodium;2-[dodecanoyl(methyl)amino]acetate
HY-125920
SODIUM LAUROYL SARCOSINATE [USP-RS]
CS-0103267
FT-0631797
L0019
S0597
E81236
A934513
Q309660
W-108241
N-methyl-N-(1-oxododecyl)-glycine, monosodium salt
Sarkosyl
SDDS
Sodium lauroyl sarcosinate
Sodium N-dodecanoyl Sarcosinate
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
Sarcosine, N-lauroyl-, sodium salt
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Compound 105
Gardol (antiseptic)
N-Lauroylsarcosine sodium
Medialan LL 99
Sarkosyl NL
Sarkosyl NL 100
Sodium lauroylsarcosine
Sodium N-lauroylsarcosinate
Sarkosyl NL 97
Sarkosyl NL 30
Sodium N-lauroylsarcosine
Gardol
N-Dodecanoyl-N-methylglycine sodium salt
Sarkosyl NL 35
N-Lauroylsarcosine sodium salt
Sodium Lauroyl Sarcosinate
Maprosyl 30
Lauroylsarcosine sodium salt
Lauroyl sarcosine sodium
Secosyl
Hamposyl L 30
Nikkol Sarcosinate LN
Sarcosinate LN
Sarcosinate LN 3
Firet L
Hamposyl L 95
N-Lauroyl-N-methylglycine sodium salt
Soypon SLP
Nikkol Sarcosinate LN 3
Oramix L 30
GM 9011
N-Dodecanoylsarcosine sodium salt
Sarkosyl
Enagicol L 30N
Soypon SLE
Sarcosinate LN 30
Medialan LD
Protelan LS 9011
Crodasinic LS 95
Perlastan L 30
Nikkol Sarcosine Na
SKL
SKL (salt)
Crodasinic LS 30
Neoscoap SLN 100
Nikkol Sarcosinate LN 30
Crodasinic LS 30NP
Maprosyl 30B
FS 701
Nikkol Sarcosinates LN
Surfacare L 30
LS 30 (surfactant)
PUJI AS02-30
AS 02-30
Amin LS 30NP
Ucefactant LS 30N
Crodasinic LS 40
LS 30
Aminosyl L 30
SP Crodasinic LS 30NP-MBAL-LQ-RB
SARKOSYL
SARCOSYL
N-Methylglycinol
N-LAUROYLSARCOSINE SODIUM SALT
GARDOL
SODIUM LAUROYL SARCOSINE
LAUROYLSARCOSINE, SODIUM SALT
N-methyl-N-(1-oxodecyl)glycine sodium salt
auroyL
GardolR
Sodium N-Lauroyl Sarcosinate
N-Lauroylsarcosine sodium salt
N-Methylglycinol
Sarkosyl
SODIUM LAUROYL SARCOSINATE
sodium [dodecanoyl(methyl)amino]acetate
glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
sodium 2-(decanoyl-methyl-amino)acetate
sodium N-lauroylsarcosinate
Glycine,N-methyl-N-(1-oxododecyl)-,sodiumsalt
n-methyl-n-(1-oxododecyl)-glycinsodiumsalt
n-methyl-n-(1-oxododecyl)glycine sodium salt
N-LAURYL SARCOSINE, SODIUM SALT
N-LAUROYLSARCOSINE NA-SALT
N-LAUROYLSARCOSINE SODIUM SALT
N-LAUROYLSARCOSINE SODIUM SALT HYDRATE
N-DODECANOYL-N-METHYLGLYCINE SODIUM SALT
Sodium lauroylsarcosinate
Sodium lauroyl sarcosinate
N-Lauroylsarcosine, sodium salt
N-Methyl-N-(1-oxododecyl) glycine, sodium salt
Sodium-N-dodecanoyl-N-methylglycinate
Sodium N-lauroyl sarcosinate

N-Lauroylsarcosine sodium salt is an anionic surfactant.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.

CAS Number: 137-16-6
EC Number: 205-281-5
MDL number: MFCD00042728
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Molecular Formula: C15H28NNaO3

N-lauroylsarcosine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, Sarcosyl, Sodium N-dodecanoyl-N-methylglycinate, Sodium N-Dodecanoyl-N-methyl-glycinate , Sarcosyl , Sodium N-Lauroyl Sarcosinate , Sarkosyl NL, Sarkosyl NL-97, Sodium N-Lauroyl Sarcosinate, N-Methyl-N-(1-oxododecyl) glycine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, sarkosyl nl, sodium lauroyl sarcosinate, n-lauroylsarcosine sodium salt, sodium n-lauroylsarcosinate, sodium lauroylsarcosinate, sarcosyl nl, maprosyl 30, compound 105, gardol, hamposyl l-30, Sodium N-Dodecanoyl-N-methyl-glycinate , Sarcosyl , Sodium N-Lauroyl Sarcosinate , Sarkosyl NL, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, Sarkosyl NL-97, Sodium N-Lauroyl Sarcosinate, N-Methyl-N-(1-oxododecyl) glycine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL, Sodium lauroyl sarcosinate,

N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.
N-Lauroylsarcosine sodium salt also decreases transcription efficiency.
N-Lauroylsarcosine sodium salt is an inhibitor of HXK.

N-Lauroylsarcosine sodium salt is an anionic surfactant.
N-Lauroylsarcosine sodium salt is soluble in water (293 g/L).
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins.

N-Lauroylsarcosine sodium salt is used multipurpose anionic surfactant widely used in the biochemistry of protein extraction and purification.
N-Lauroylsarcosine sodium salt is an ionic detergent used to purify membrane proteins
N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase.

N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.
N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).

N-Lauroylsarcosine sodium salt is soluble in water (293 g/L).
N-Lauroylsarcosine sodium salt is an anionic detergent.
N-Lauroylsarcosine sodium salt is an anionic surfactant.

USES and APPLICATIONS of N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt has been used in a study to assess involvement of histamine released from epidermal keratinocytes.
N-Lauroylsarcosine sodium salt has also been used in a study to develop a simple method for extracting DNA from Cryptosporidium oocysts.
N-Lauroylsarcosine sodium salt is used cell Lysis Reagent | Electrophoresis Chromatography | Detergents

N-Lauroylsarcosine sodium salt has been especially used with membrane proteins.
Key Applications of N-Lauroylsarcosine sodium salt: Cell Lysis Reagent | Electrophoresis Chromatography | Detergents
N-Lauroylsarcosine sodium salt is used in a study to assess involvement of histamine released from epidermal keratinocytes.

N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoproteins.
N-Lauroylsarcosine sodium salt has been used as one of the components of the lysing solution in the cornet assay.
N-Lauroylsarcosine sodium salt has been used for lysing protoplasts in the process of chromosomal DNA isolation form Streptococcus mutans.

N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoprotein′s; reported to inhibit hexokinase.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
N-Lauroylsarcosine sodium salt has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.

N-Lauroylsarcosine sodium salt inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).
N-Lauroylsarcosine sodium salt is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase.
N-Lauroylsarcosine sodium salt is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).

NOTES OF N-LAUROYLSARCOSINE SODIUM SALT:
Hygroscopic, store N-Lauroylsarcosine sodium salt away form water/moisture.
Store N-Lauroylsarcosine sodium salt in cool.
Keep N-Lauroylsarcosine sodium salt container tightly closed in a dry and well-ventilated place.
Store N-Lauroylsarcosine sodium salt away from oxidizing agent and reducing agent.

BIOCHEM/PHYSIOL ACTIONS OF N-LAUROYLSARCOSINE SODIUM SALT:
N-Lauroylsarcosine sodium salt is an anionic surfactant which also has protein denaturant potency.
In addition, N-Lauroylsarcosine sodium salt has been shown as a microbicide for sexually transmitted diseases.

PHYSICAL and CHEMICAL PROPERTIES of N-LAUROYLSARCOSINE SODIUM SALT:
CAS Number: 137-16-6
Molecular Weight: 293.38
Beilstein: 5322974
EC Number: 205-281-5
MDL number: MFCD00042728
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Melting Point: 44°C to 47°C
Color: White
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa
Beilstein: 5322974
Sensitivity: Hygroscopic
Merck Index: 14,4368
Solubility Information: Soluble in water (293g/L).

Formula Weight: 293.38
Percent Purity: 95%
Physical Form: Crystalline Powder
Chemical Name or Material: N-Lauroylsarcosine sodium salt
Physical state: powder
Color: white
Odor: characteristic
Melting point/freezing point:
Melting point: 146 °C
Initial boiling point and boiling range: 350 - 410 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 267 °C - closed cup

Autoignition temperature: No data available
Decomposition temperature: No data available
pH: ca.8 at 30 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility at 20 °C soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 0,02 hPa at 20 °C
Density: 1,14 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available

Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
CAS NUMBER: 137-16-6
MOLECULAR FORMULA: C15H28NO3 • Na
MOLECULAR WEIGHT: 293.4
BEILSTEIN REGISTRY NUMBER: 5322974
EC NUMBER: 205-281-5
MDL NUMBER: MFCD00042728
CAS Min %: 94
CAS Max %: 100
Melting Point: 45.0°C to 47.0°C

Color: White
pH: 7.0 to 9.0
Loss on Drying: 7% max. ()
Infrared Spectrum: Authentic
Assay Percent Range: 0.95
Linear Formula: NaCO2CH2N(CH3)CO(CH2)10CH3
Merck Index: 154401
Solubility Information (10% in water): Almost clear colorless to light yellow
Formula Weight: 293.39
Percent Purity: 95%
Physical Form: Solid
Chemical Name or Material: N-Lauroylsarcosine sodium salt

FIRST AID MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Description of first-aid measures:
No data available
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Environmental precautions:
No data available
-Methods and materials for containment and cleaning up:
No data available

FIRE FIGHTING MEASURES of N-LAUROYLSARCOSINE SODIUM SALT:
-Extinguishing media:
No data available
-Further information:
No data available

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-LAUROYLSARCOSINE SODIUM SALT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Prevent product from entering drains.

HANDLING and STORAGE of N-LAUROYLSARCOSINE SODIUM SALT:
-Conditions for safe storage, including any incompatibilities:
hygroscopic
Store under inert gas.

STABILITY and REACTIVITY of N-LAUROYLSARCOSINE SODIUM SALT:
-Reactivity:
No data available
-Chemical stability:
No data available
-Conditions to avoid:
No data available
-Incompatible materials:
No data available

1-Methylpyrrolidine; Methylpyrrolidine; N-Methyltetrahydropyrrole CAS NO. 120-94-5

N-Monomethylaniline; N-phenylmethylamine; Anilinomethane; MA; (methylamino) benzene; Monomethylaniline; N-methylaminobenzene; N-Methylbenzeneamine; N-Methyl-phenylamine; ANILINOMETHANE; LABOTEST-BB LTBB000436; MONOMETHYLANILINE; N-METHYLAMINOBENZENE; N-METHYLANILINE; N-MONOMETHYLANILINE; (Methylamino)benzene; Benzenamine, N-methyl-; Benzenenamine, N-methyl-; methylaniline(non-specificname); methylaniline-n; Methylphenylamine; n’-BIcthylanilin; n-methyl-anilin; N-Methylanilinium ion; n-methyl-benzenamin CAS NO:100-61-8

N-methyl 2-pyrrolidone (NMP) is almost colorless liquid with an amine odor.
N-methyl 2-pyrrolidone (NMP) is a solvent used in a range of products.
N-methyl 2-pyrrolidone (NMP) is chemically and thermally stable, and not corrosive.

CAS Number: 872-50-4
EC Number: 212-828-1
MDL number: MFCD00003193
Chemical formula: C5H9NO

SYNONYMS:
1-Methylpyrrolidin-2-one, 1-Methyl-2-pyrrolidone, N-Methylpyrrolidone, N-Methylpyrrolidinone, Pharmasolve, 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP, 1-METHYL-2-PYRROLIDINONE, 872-50-4, N-Methylpyrrolidone, N-Methyl-2-pyrrolidone, 1-methylpyrrolidin-2-one, Methylpyrrolidone, N-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, M-Pyrol, Methyl pyrrolidone, 1-Methylpyrrolidone, 1-Methylpyrrolidinone, N-Methylpyrrolidinone, n-methyl-pyrrolidone, 2-Pyrrolidinone, 1-methyl-, 1-Methyl-5-pyrrolidinone, 1-Methylazacyclopentan-2-one, NMP, N-methylpyrrolidin-2-one, N-Methyl-gamma-butyrolactam, N-methyl pyrrolidone, pharmasolve, 1-methylpyrrolidine-2-one, N-methyl pyrrolidinone, Methyl-2-pyrrolidinone, 1-methyl-2-pyrrolidon, Methylpyrrolidinone, Agsolex 1, 2-Pyrrolidinone, methyl-, 2687-44-7, N-Methyl-alpha-pyrrolidone, N-Methyl-alpha-pyrrolidinone, NSC 4594, CCRIS 1633, Methylpyrrolidone [NF], N-Methylpyrrolid-2-one, 51013-18-4, DTXSID6020856, HSDB 5022, UNII-JR9CE63FPM, JR9CE63FPM, NSC-4594, Pyrol M, EINECS 212-828-1, Microposit 2001, CHEBI:7307, 26138-58-9, AI3-23116, 1-methyl-2-pyrolidinone, MFCD00003193, 1-methyl-pyrrolidin-2-one, N-Methyl-.alpha.-pyrrolidone, CHEMBL12543, DTXCID60856, N-Methyl-.gamma.-butyrolactam, N-Methyl-.alpha.-pyrrolidinone, NSC4594, EC 212-828-1, N 0131, 1-Methyl-2-pyrrolidinone, HPLC Grade, SL 1332, M 0418, METHYL PYRROLIDONE (II), METHYL PYRROLIDONE [II], METHYLPYRROLIDONE (USP-RS), METHYLPYRROLIDONE [USP-RS], N-METHYLPYRROLIDONE (MART.), N-METHYLPYRROLIDONE [MART.], N-METHYLPYRROLIDONE (USP-RS), N-METHYLPYRROLIDONE [USP-RS], N-Methylpyrrolidon, CAS-872-50-4, N-METHYLPYRROLIDONE (EP MONOGRAPH), N-METHYLPYRROLIDONE [EP MONOGRAPH], N-methyl-pyrrolidinone, N-Methylpyrrolidone; 1-Methylpyrrolidin-2-one, Methylpyrrolidone, N-, Pyrrolidinone, methyl-, N-Methyl-2-pyrrolidon, 1-methyl-2-pyrolidone, N-methyl-pyrrolidin-2-one, 1-Methyl-2-pyrrolidinone, puriss. p.a., >=99.0% (GC), Micropure ultra, N-methylpyrolidinone, N-methypyrrolidone, Max-1 peptide, N-methylpirrolidone, 1methylpyrrolidinone, n-methyl pyrrolidon, N-methy pyrrolidone, N-methyl-pyrolidone, N-methyl-pyrollidone, N-methylpyrrolidone, 1-methylpyrolidinone, n-methylpyrollidinone, N-Methylpyrrolidione, N-methlypyrrolidinone, N-methyl pirrolidone, N-methyl pyrollidone, N-methyl-pyrollidone, N-methylpyrrolidone-, NMP,SP Grade, 1-methyl pyrrolidone, 1-methyl-pyrrolidone, methyl-2-pyrrolidone, N-methy pyrrolidinone, N-methyl pyrolidinone, N-methyl-p, 1-Methylazacyclopentane-2-one, GTPL9520, 1-Methyl-2-pyrrolidin-2-one, 1-methyl-2-pyrrolidinone (nmp), 1-METHYLPYRROLIDONE [MI], N-METHYL-2-KETOPYRROLIDINE, HY-Y1275, Tox21_202350, Tox21_300097, 1-Methyl-2-pyrrolidinone, 99.5%, 1-Methyl-2-pyrrolidinone, anhydrous, BDBM50353587, N-Methyl pyrrolidon (Peptide Grade), s6282, STL183295, N-Methyl-2-pyrrolidinone ACS reagent, AKOS000120930, 1-Methyl-2-pyrrolidinone, BioSolv(R), DB12521, 1-Methyl-2-pyrrolidone, Reagent, ACS, 1-METHYL-2-PYRROLIDINONE [HSDB], NCGC00247902-01, NCGC00247902-02, NCGC00253935-01, NCGC00259899-01, BP-31156, DB-230823, DB-231528, 1-Methyl-2-pyrrolidone (Low water content), AM20110252, CS-0017258, M0418, M3055, NS00009178, 1-Methyl-2-pyrrolidinone, analytical standard, 1-Methyl-2-pyrrolidinone, anhydrous, 99.5%, 1-Methyl-2-pyrrolidinone, for HPLC, >=99%, 1-Methyl-2-pyrrolidinone, for synthesis, 99%, D78116, Q33103, Residual Solvent Class 2 - N-Methylpyrrolidone, 1-Methyl-2-pyrrolidinone, ReagentPlus(R), 99%, 1-Methyl-2-pyrrolidinone, Spectrophotometric Grade, 2-PYRROLIDONE,1-METHYL MFC5 H9 N1 O1, A842053, 1-Methyl-2-pyrrolidinone, ACS reagent, >=99.0%, 2,5-Dichloro-4,6-dimethyl pyridine-3-carbonitrile, J-504921, J-803017, 1-Methyl-2-pyrrolidinone, biotech. grade, >=99.7%, 1-Methyl-2-pyrrolidinone, Electronic/Cleanroom Grade, 1-Methyl-2-pyrrolidinone, p.a., ACS reagent, 99%, 1-Methyl-2-pyrrolidone, anhydrous, water 40ppm max., 1-Methyl-2-Pyrrolidinon, 99.5 %, ExtraDry, AcroSeal?, 1-Methyl-2-pyrrolidinone, SAJ first grade, >=98.0%, Z104478382, 1-Methyl-2-pyrrolidinone, spectrophotometric grade, >=99%, 1-Methyl-2-pyrrolidinone, Vetec(TM) reagent grade, 98%, InChI=1/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H, 1-Methyl-2-pyrrolidinone, for metal speciation analysis, >=99.0% (GC), Methylpyrrolidone, United States Pharmacopeia (USP) Reference Standard, N-Methylpyrrolidone, Pharmaceutical Secondary Standard; Certified Reference Material, 26876-92-6, G N-Methyl-2-Pyrrolidone, 1-Methyl-2-Pyrrolidone, 1-Methyl-Pyrrolidine-2-one, N-Methyl-2-Pyrrolidinone, 1-methylazacyclopentan-2-one, N-methyl-gamma-butyrolactam, N-methylpyrrolidinone, N-methyl-2-pyrrolidinone, methylpyrrolidone, N-methylpyrrolidone, N-methyl-alpha-pyrrolidone, 1-methylpyrrolidone, 1-methyl-2-pyrrolidone, NMP, M-pyrol, 1-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, 1-Methyl-5-pyrrolidinone, 1-Methylazacyclopentan-2-one, 1-Methylpyrrolidinone, 1-Methylpyrrolidone, 2-Pyrrolidinone, 1-methyl-, M-Pyrol, Methylpyrrolidone, N-Methyl-2-pyrrolidinone, N-Methyl-2-pyrrolidone, N-Methyl-gamma-butyrolactam, N-Methylpyrrolidinone, N-Methylpyrrolidone, NMP, Norleucine, 5-oxo-, DL, [ChemIDplus] UN1993, 1-Methyl-2-pyrrolidone, N-Methylpyrrolidone, N-Methylpyrrolidinone, NMP, 1-Methyl-2-pyrrolidone, NMP, N-methylpyrrolidinone, N-methyl-2-pyrrolinone, 1-methyl-5-pyrrolidinone, methylpyrrolidone, N-methylpyrrolidone, composite constituent, N-Methyl Pyrrolidone, 872-50-4, 1-Methyl-Pyrrolidone, Methyl Pyrrolidone, Methyl Pyrrolidone, N-Methyl-2-Pyrrolidone, N-Methyl-2-Pyrrolidone, N-Methylpyrrolidinone, N-Methyl-2-Pyrrolidinone, 1-Methyl-Pyrrolidin-2-one, 1-Methylpyrrolidin-2-one, NMP Solvent, NMP

N-methyl 2-pyrrolidone (NMP) is a pale yellow organic compound and is a non-flammable product.
N-methyl 2-pyrrolidone (NMP) is miscible with water and most other solvents, always test a little and see how it mixes.
N-methyl 2-pyrrolidone (NMP) is denser than water at 1.03g/cc with a boiling range of 56 ºC.

N-methyl 2-pyrrolidone (NMP) is a flammable organic liquid consisting of a 5-membered lactam.
Available in various quantities and reagent grades, N-methyl 2-pyrrolidone (NMP) is a dipolar aprotic solvent with petrochemical, plastic, and pharmaceutical applications.

N-methyl 2-pyrrolidone (NMP) is a clear colorless liquid with a fish-like odor.
N-methyl 2-pyrrolidone (NMP) is almost colorless liquid with an amine odor.
N-methyl 2-pyrrolidone (NMP) is a solvent used in a range of products.

The average consumer is most likely to encounter N-methyl 2-pyrrolidone (NMP) in paint strippers, even though safer alternatives exist.
N-methyl 2-pyrrolidone (NMP) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

N-methyl 2-pyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.
N-methyl 2-pyrrolidone (NMP) is produced and imported into the United States, with use estimated at over 184 million pounds per year.

N-methyl 2-pyrrolidone (NMP) is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).
Organic and inorganic substances are highly soluble in N-methyl 2-pyrrolidone (NMP).

N-methyl 2-pyrrolidone (NMP) mixes with water in all proportions.
N-methyl 2-pyrrolidone (NMP) has a high flash point compared to similar solvents.
The boiling point of N-methyl 2-pyrrolidone (NMP) is high, the freezing point is low, and handling is easy.

N-methyl 2-pyrrolidone (NMP) is chemically and thermally stable, and not corrosive.
N-methyl 2-pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid.
N-methyl 2-pyrrolidone (NMP) has been closely linked to developmental impacts including miscarriages.

N-methyl 2-pyrrolidone (NMP) has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.
Additionally, the polar nature and the low surface tension of N-methyl 2-pyrrolidone (NMP) makes it an excellent cleaning medium and paint stripping solvent.

N-methyl 2-pyrrolidone (NMP) is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in.
N-methyl 2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
N-methyl 2-pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.

N-methyl 2-pyrrolidone (NMP) is miscible with water and with most common organic solvents.
N-methyl 2-pyrrolidone (NMP) is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).

N-methyl 2-pyrrolidone (NMP) appears as a clear colorless liquid with a "fishlike" odor.
N-methyl 2-pyrrolidone (NMP) is denser than water.
Flash point of N-methyl 2-pyrrolidone (NMP) is 199 °F.

N-methyl 2-pyrrolidone (NMP) is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.
N-methyl 2-pyrrolidone (NMP) has a role as a polar aprotic solvent.

N-methyl 2-pyrrolidone (NMP) is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones.
N-methyl 2-pyrrolidone (NMP) is under investigation for the treatment of Multiple Myeloma.
N-methyl 2-pyrrolidone (NMP) is a natural product found in Microtropis japonica, Melicope hayesii, and other organisms with data available.

N-methyl 2-pyrrolidone (NMP) is a chemical compound with 5-membered lactam structure.
N-methyl 2-pyrrolidone (NMP) is a colorless to slightly yellow liquid miscible with water.
N-methyl 2-pyrrolidone (NMP) has been identified as a reproductive toxicant, first by California in 2001 and then by the European Commission in 2003.

In the face of increasing regulation, some manufacturers are considering alternative solvents for some applications, especially where worker exposure is difficult to control, such as in paint stripping, graffiti removal, and agriculture.
N-methyl 2-pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.

USES and APPLICATIONS of N-METHYL 2-PYRROLIDONE (NMP):
N-methyl 2-pyrrolidone (NMP) is a solvent used in a variety of industries and applications such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning, and industrial/ domestic cleaning.
Due to its good solvency properties, N-methyl 2-pyrrolidone (NMP) is used to dissolve a wide range of polymers.

N-methyl 2-pyrrolidone (NMP) is used in the surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-methyl 2-pyrrolidone (NMP) is a used solvent for polymers, textile coatings, resins, agricultural chemicals, paint removal, degreasing; petrochemical processing; pharmaceuticals.

N-methyl 2-pyrrolidone (NMP) is used as a solvent for chemicals and resins in the microelectronics and pharmaceutical industries.
N-methyl 2-pyrrolidone (NMP) is widely used to replace other solvents, e.g., for paint stripping and lube oil extraction.
N-methyl 2-pyrrolidone (NMP) is used as a solvent for pesticides, coatings, adhesives, dyes, pigments, polymers, and polyurethane foam cleanup.

N-methyl 2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
N-methyl 2-pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.
N-methyl 2-pyrrolidone (NMP) is miscible with water and with most common organic solvents.

N-methyl 2-pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-methyl 2-pyrrolidone (NMP) is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials

N-methyl 2-pyrrolidone (NMP) is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Other release to the environment of N-methyl 2-pyrrolidone (NMP) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

N-methyl 2-pyrrolidone (NMP) can be found in complex articles, with no release intended: vehicles and vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).
N-methyl 2-pyrrolidone (NMP) is used in the following areas: formulation of mixtures and/or re-packaging.

N-methyl 2-pyrrolidone (NMP) is used in the following products: pH regulators and water treatment products and laboratory chemicals. N-methyl 2-pyrrolidone (NMP) is used in the following areas: scientific research and development, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.

Other release to the environment of N-methyl 2-pyrrolidone (NMP) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

N-methyl 2-pyrrolidone (NMP) is used in the following products: metal surface treatment products, non-metal-surface treatment products, polymers and coating products.
Release to the environment of N-methyl 2-pyrrolidone (NMP) can occur from industrial use: formulation of mixtures and manufacturing of the substance.

N-methyl 2-pyrrolidone (NMP) is used in the following products: semiconductors, washing & cleaning products, metal surface treatment products and non-metal-surface treatment products.
N-methyl 2-pyrrolidone (NMP) is used in the following areas: formulation of mixtures and/or re-packaging.

N-methyl 2-pyrrolidone (NMP) is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of N-methyl 2-pyrrolidone (NMP) can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.

Release to the environment of N-methyl 2-pyrrolidone (NMP) can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
N-methyl 2-pyrrolidone (NMP) is used for the manufacture of: chemicals.

N-methyl 2-pyrrolidone (NMP) is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-methyl 2-pyrrolidone (NMP) is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.

Its good solvency properties have led to N-methyl 2-pyrrolidone (NMP)'s use to dissolve a wide range of polymers.
Specifically, N-methyl 2-pyrrolidone (NMP) is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-methyl 2-pyrrolidone (NMP) is also used as a solvent in the commercial preparation of polyphenylene sulfide.

In the pharmaceutical industry, N-methyl 2-pyrrolidone (NMP) is used in the formulation for drugs by both oral and transdermal delivery routes.
It is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because N-methyl 2-pyrrolidone (NMP) has a unique ability to dissolve polyvinylidene fluoride binder.

N-methyl 2-pyrrolidone (NMP) is used in petrochemical processing, and as a solvent for surface treatment of textiles, resins and metal coated plastics or as a paint stripper.
In the pharmaceutical industry, N-methyl 2-pyrrolidone (NMP) is used in the formulation for drugs by both oral and transdermal delivery routes.

-Agrochemicals:
N-methyl 2-pyrrolidone (NMP) can be used as solvent during synthesis or as a formulation agent.
N-methyl 2-pyrrolidone (NMP) is polar aprotic solvent with the properties of low toxicity, high boiling point, powerful solvency, good selectivity and stability.

N-methyl 2-pyrrolidone (NMP) is widely applied to aromatic hydrocarbons extracting, acetylene and diolefine purification.
N-methyl 2-pyrrolidone (NMP) can be used as polymer solvents and polymerization process medium, etc., which are called engineering plastics.
Besides, N-methyl 2-pyrrolidone (NMP) can also be used as aromatic fibre, insulate pesticide, pigment and detergent, etc.

N-methyl 2-pyrrolidone (NMP) is used Electronics, Paints & coatings,
Polymer & plastic, Process solvents, Solvents/stripping agents, and Wire wrappers.
N-methyl 2-pyrrolidone (NMP) is used as a solvent for engineering polymers and coating resins.

-Electronics:
N-methyl 2-pyrrolidone (NMP) is used as photoresist stripper, for defluxing, degreasing and cleaning.
N-methyl 2-pyrrolidone (NMP) is a solvent for the production of FCCL, polyamide/polyimide wire enamels, epoxy and polyurethane coatings, ...

-Pharmaceuticals:
NMP can be used as solvent, extraction medium, …
Industrial and household cleaning:
NMP is used for paint stripping, in graffiti removers, oven cleaners, in automotive and industrial cleaner formulations, ...

-Petrochemical processing:
N-methyl 2-pyrrolidone (NMP) is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction, lube oil purification, ...
As illustration for the strong selectivity of N-methyl 2-pyrrolidone (NMP) towards acetylene, the table below shows the solubility of acetylene in various solvents.

CHARACTERISTICS OF N-METHYL 2-PYRROLIDONE (NMP):
N-methyl 2-pyrrolidone (NMP) is a 5-member-ring compound containing nitrogen.
N-methyl 2-pyrrolidone (NMP) has a wide range of uses due to the following excellent characteristics.

PREPARATION OF N-METHYL 2-PYRROLIDONE (NMP):
N-methyl 2-pyrrolidone (NMP) is produced industrially by a typical ester-to-amide conversion, by treating gamma-butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 200,000 to 250,000 tons are produced annually.

PHYSICAL and CHEMICAL PROPERTIES of N-METHYL 2-PYRROLIDONE (NMP):
Molecular Weight: 99.14 g/mol
Appearance: Clear colorless liquid
Odor: Faint amine smell
Specific Gravity (25/4°C): 1.027
Viscosity (mPa･s): 1.89 (25°C)
Boiling Point (°C): 202
Freezing Point (°C): -23
Vapor specific gravity: 3.4
Flash Point (°C): 99 (open cup)
Autoignition Temperature (°C): 252
CAS number: 872-50-4
EC index number: 606-021-00-7

EC number: 212-828-1
Hill Formula: C₅H₉NO
Molar Mass: 99.13 g/mol
HS Code: 2933 79 90
Boiling point: 202 °C (1013 hPa)
Density: 1.03 g/cm³ (25 °C)
Explosion limit: 1.3 - 9.5% (V)
Flash point: 91 °C
Ignition temperature: 245 °C
Melting Point: -24.2 °C
pH value: 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure: 0.32 hPa (20 °C)
Solubility: 1000 g/l

Physical description: A clear colorless liquid with a fish-like odor.
Boiling point: 396°F
Molecular weight: 99.13
Freezing point/melting point: -9°F
Vapor pressure
Flash point: 204°F
Vapor density: 3.4
Specific gravity: 1.03
Ionization potential
Lower explosive limit (LEL)
Upper explosive limit (UEL)
NFPA health rating: 2
NFPA fire rating: 2
NFPA reactivity rating: 0

Appearance (Clarity): Clear
Assay (GC): min. 99.9%
Residual solvents
GC-HS Class 1: max. 1ppm
GC-HS Class 2: max. 10ppm
GC-HS Class 3: max. 50ppm
Density (g/ml) @ 20°C: 1.029-1.031
Refractive Index (20°C): 1.470-1.471
Boiling Range: 201-202°C
Non Volatile Matter: max. 0.0005%
Water (KF): max. 0.05%
Appearance (Colour): Colorless
Appearance (Form): Liquid

Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.031
Refractive Index (20°C): 1.470-1.471
Boiling Range: 201-202°C
Non Volatile Matter: max. 0.001%
Water (KF): max. 0.1%
Chemical formula: C5H9NO
Molar mass: 99.133 g·mol−1
Density: 1.028 g/cm3
Melting point: −24 °C (−11 °F; 249 K)
Boiling point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water: Soluble

Solubility in Ethanol, acetone, diethylether,
ethyl acetate, chloroform, benzene: Soluble
log P: −0.40
Molecular Weight: 99.14
Appearance: Clear colorless liquid
Odor: Faint amine smell
Specific Gravity (25/4℃): 1.027
Viscosity(mPa･s) : 1.89（25℃）
Boiling Point (℃): 202
Freezing Point (℃): -23
Vapor specific gravity: 3.4
Flash Point (℃): 99 (open cup)
Autoignition Temperature (℃): 252

Physical state: clear, liquid
Color: colorless
Odor: amine-like
Melting point/freezing point:
Melting point/range: -24 °C
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 9,5 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 91 °C
Autoignition temperature :245 °C at 1.013 hPa - DIN 51794
Decomposition temperature: No data available
pH: 8,5 - 10,0 at 100 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 1,661 mPa.s at 25 °C

Water solubility: 1.000 g/l at 20 °C - soluble
Partition coefficient: n-octanol/water:
log Pow: -0,46 at 25 °C
Bioaccumulation is not expected.
Vapor pressure: 0,32 hPa at 20 °C
Density: 1,028 g/mL at 25 °C
Relative densit:y No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:

Conductivity: 0,2 - 0,4 µS/cm
Surface tension: 40,4 mN/m
Relative vapor density: 3,42 - (Air = 1.0)
Boiling point: 396°F
Molecular weight: 99.13
Freezing point/melting point: -9°F
Flash point: 204°F
Vapor density: 3.4
Specific gravity: 1.03
NFPA health rating: 2
NFPA fire rating: 2
NFPA reactivity rating: 0
Appearance (Clarity): Clear
Appearance (Colour): Colourless

Appearance (Form): Liquid
Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.033
Refractive Index (20°C): 1.470-1.472
Boiling Range: 202-204°C
Water (KF): max. 0.1%
Molecular Weight： 99.13110
Exact Mass： 99.13
EC Number： 212-828-1
UNII： JR9CE63FPM
ICSC Number： 0513
NSC Number： 4594
UN Number： 1993

DSSTox ID： DTXSID6020856
Color/Form： Clear liquid
HScode: 2933990090
PSA: 20.31000
XLogP3： 0.17650
Density： 1.027 g/cm3 @ Temp: 25 °C
Melting Point： -25 °C
Boiling Point： 202 °C @ Press: 760 Torr
Flash Point： 91ºC
Refractive Index： n20/D 1.479
Water Solubility： H2O: >=10 g/100 mL at 20 ºC
Storage Conditions： 2-8ºC
Vapor Pressure： 0.29 mm Hg ( 20 °C)

Vapor Density： 3.4 (vs air)
Explosive limit： vol% in air: 1.3.5
Odor： Mild amine odor
PH： pH = 7.7-8
Henrys Law Constant： 3.20e-09 atm-m3/mole
Experimental Properties：
Dipole moment at 25 °C: 4.09 debye
Dielectric constant at 25 °C: 32.3
Hydroxy radical rate constant = 7.4X10-11 cu cm/molecule-sec at 25 °C
Air and Water Reactions： Soluble in water.
Reactive Group： Amides and Imides
Autoignition Temperature： 655 °F (346 °C)|245 °C
Heat of Combustion： 719 kcal/mol
Heat of Vaporization： 127.3 kcal/Kg

Critical Temperature & Pressure：
Critical temperature = 451 °C
Critical pressure = 4.78 MPa
Empirical formula: C5H9NO
Molar mass (M): 99,13 g/mol
Density (D): 1,03 g/cm³
Boiling point (bp): 204,3 °C
Flash point (flp): 91 °C
Melting point (mp): -24,2 °C
CAS Number: 872-50-4
Molecular Weight: 99.13 g/mol
Appearance: Colorless liquid
Melting Point: -24 C

Boiling Point: 202 C
Density: 1.028 g/mL at 25 C
Melting point: -24 °C (lit.)
Boiling point: 202 °C (lit.) 81-82 °C/10 mmHg (lit.)
Density: 1.028 g/mL at 25 °C (lit.)
vapor density: 3.4 (vs air)
vapor pressure: 0.29 mm Hg ( 20 °C)
refractive index: n20/D 1.479
Flash point: 187 °F
storage temp.: Store at +5°C to +30°C.
solubility: ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
form: Liquid
pka: -0.41±0.20(Predicted)

color: ≤20(APHA)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
Odor: Slight amine odor
PH Range: 7.7 - 8.0
explosive limit: 1.3-9.5%(V)
Water Solubility: >=10 g/100 mL at 20 ºC
Sensitive: Hygroscopic
λmax: 283nm(MeOH)(lit.)
Merck: 14,6117
BRN: 106420
Stability: Stable, but decomposes upon exposure to light.
InChIKey: SECXISVLQFMRJM-UHFFFAOYSA-N
LogP: -0.46 at 25℃
Chemical Formula: C5H9NO
Molar Mass: 99.133 g·mol−1
Density: 1.028 g/cm³

Melting Point: −24 °C (−11 °F; 249 K)
Boiling Point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in Water: Soluble
Solubility in Ethanol, Acetone, Diethyl Ether,
Ethyl Acetate, Chloroform, Benzene: Soluble
log P: −0.40
Molecular Weight: 99.13 g/mol
XLogP3: -0.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0

Exact Mass: 99.068413911 g/mol
Monoisotopic Mass: 99.068413911 g/mol
Topological Polar Surface Area: 20.3 Å²
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 90.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

FIRST AID MEASURES of N-METHYL 2-PYRROLIDONE (NMP):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-METHYL 2-PYRROLIDONE (NMP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of N-METHYL 2-PYRROLIDONE (NMP):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-METHYL 2-PYRROLIDONE (NMP):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: 60 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A-(P2)
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-METHYL 2-PYRROLIDONE (NMP):
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
Take precautionary measures against static discharge.
*Hygiene measures:
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.
Moisture sensitive.

STABILITY and REACTIVITY of N-METHYL 2-PYRROLIDONE (NMP):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

1-Methyl-2-pyrrolidinone; 1-Methyl-5-Pyrrolidinone; Methylpyrrolidone; N-Methylpyrrolidone; N-Methyl-2-Pyrrolidone; NMP; 1-Methyl-2-pyrrolidone; m-pyrrole; 1-Methylpyrrolidinone; N-methylpyrrolidinone; N-Methyl-2-pyrrolidinone; cas no:872-50-4

N-methyl pyrrolidinone (NMP) is a highly versatile organic solvent with the chemical formula C5H9NO.
N-methyl pyrrolidinone is a colorless to pale yellow liquid that is soluble in water and most organic solvents.
N-methyl pyrrolidinone is widely used in various industrial applications due to its unique properties, including high boiling point, low vapor pressure, good solvency, and excellent chemical stability.

CAS Number: 872-50-4
EC Number: 212-828-1

APPLICATIONS

N-methyl pyrrolidinone (NMP) has a wide range of industrial applications, including:

Solvent for the production of electronics, such as semiconductors, displays, and printed circuit boards (PCBs)
Solvent for the production of lithium-ion batteries for electric vehicles and electronic devices
Solvent for the manufacture of pharmaceuticals, such as antibiotics, antifungal agents, and analgesics
Solvent for the production of polymers, such as polyvinylpyrrolidone (PVP), nylon, and aramid fibers
Solvent for the production of synthetic fibers, such as carbon fibers and aramid fibers
Solvent for the production of agrochemicals, such as herbicides and insecticides
Solvent for the extraction of petrochemicals and natural gas
Solvent for the formulation of personal care products, such as lotions and shampoos
Solvent for the production of resins, such as epoxy resins, and adhesives
Solvent for the printing industry, where it is used to clean printing plates and equipment
Solvent for the production of coatings, paints, and varnishes
Solvent for the production of nanomaterials, such as graphene
Solvent for the extraction of metals from ores and other raw materials.

N-methyl pyrrolidinone's excellent solvency, high boiling point, low vapor pressure, and stability make it a popular choice in these and other industrial applications.
N-methyl pyrrolidinone is commonly used as a solvent in the production of semiconductors and other electronics.

Lithium-ion batteries, which power many electronic devices and electric vehicles, are produced using N-methyl pyrrolidinone as a solvent.
In the pharmaceutical industry, N-methyl pyrrolidinone is used as a solvent in the production of various drugs, including antibiotics and antifungal agents.

N-methyl pyrrolidinone is a key component in the production of polyvinylpyrrolidone (PVP), which is used in a variety of applications, including as a binder in tablets and capsules.
The excellent solvency of N-methyl pyrrolidinone makes it useful in the production of synthetic fibers, such as carbon fibers and aramid fibers.

The agrochemical industry uses N-methyl pyrrolidinone as a solvent for herbicides and insecticides.
In the oil and gas industry, N-methyl pyrrolidinone is used as a solvent for the extraction of petrochemicals and natural gas.

N-methyl pyrrolidinone is a popular solvent in the formulation of personal care products, such as lotions and shampoos.
The production of epoxy resins and adhesives often involves the use of N-methyl pyrrolidinone as a solvent.
The printing industry uses N-methyl pyrrolidinone as a solvent to clean printing plates and equipment.

The high boiling point and low vapor pressure of N-methyl pyrrolidinone make it useful in the production of coatings, paints, and varnishes.
N-methyl pyrrolidinone is used in the production of nanomaterials, such as graphene, due to its excellent solvency and stability.

N-methyl pyrrolidinone is also used in the extraction of metals from ores and other raw materials.
In the production of carbon nanotubes, N-methyl pyrrolidinone is used as a solvent to dissolve the starting material.

The textile industry uses N-methyl pyrrolidinone as a solvent to produce synthetic fibers and fabrics.
N-methyl pyrrolidinone is used in the production of paints and coatings for the automotive industry.
The electronics industry uses N-methyl pyrrolidinone as a solvent for the production of organic light-emitting diodes (OLEDs).

The production of polyurethane foams often involves the use of N-methyl pyrrolidinone as a solvent.
The food industry uses N-methyl pyrrolidinone as a solvent in the production of flavorings and fragrances.

In the production of resins and adhesives, N-methyl pyrrolidinone is used as a solvent and a reaction medium.
N-methyl pyrrolidinone is used in the production of high-performance fibers, such as Kevlar, due to its ability to dissolve a wide range of polymers.

The automotive industry uses N-methyl pyrrolidinone as a solvent for the production of car parts and components.
N-methyl pyrrolidinone is used in the production of inkjet inks, which are used in printers and other electronic devices.

N-methyl pyrrolidinone is used as a solvent in the production of synthetic fibers and resins.
N-methyl pyrrolidinone is a common solvent for polymeric materials, such as polyvinyl chloride (PVC) and polyurethanes.
In the pharmaceutical industry, N-methyl pyrrolidinone is used as a reaction solvent and extraction agent.

N-methyl pyrrolidinone is used in the synthesis of numerous pharmaceuticals, such as analgesics, antibiotics, and antivirals.
N-methyl pyrrolidinone is a solvent for electrolyte solutions in lithium-ion batteries.

N-methyl pyrrolidinone is used as a solvent and wetting agent in the manufacture of photoresist materials for semiconductor manufacturing.
N-methyl pyrrolidinone is used as a solvent in the production of adhesives and sealants.

N-methyl pyrrolidinone is a solvent for dyes and pigments in the textile industry.
N-methyl pyrrolidinone is used as a reaction solvent in the synthesis of advanced materials, such as carbon nanotubes and graphene.

N-methyl pyrrolidinone is a solvent for polymers used in the production of plastic films, coatings, and laminates.
N-methyl pyrrolidinone is used as a solvent in the production of agricultural chemicals, such as herbicides and fungicides.

N-methyl pyrrolidinone is used as a cleaning agent in the electronics industry, especially for the removal of photoresist materials.
N-methyl pyrrolidinone is used as a solvent for inkjet printing inks and toners.
N-methyl pyrrolidinone is a solvent for metal-organic frameworks (MOFs), which have potential applications in gas storage and separation.

N-methyl pyrrolidinone is used as a solvent for gas scrubbing in carbon capture and storage (CCS) systems.
N-methyl pyrrolidinone is used as a solvent for the extraction of aromatic hydrocarbons from petroleum.

N-methyl pyrrolidinone is used as a reaction solvent in the synthesis of fuel additives, such as detergents and dispersants.
N-methyl pyrrolidinone is a solvent for resins used in the production of composite materials, such as fiberglass.

N-methyl pyrrolidinone is used as a solvent for the production of industrial coatings, such as automotive paints.
N-methyl pyrrolidinone is used as a solvent for the production of polyether polyols, which are used in the production of polyurethane foams and elastomers.

N-methyl pyrrolidinone is used as a solvent in the production of printing inks for packaging materials.
N-methyl pyrrolidinone is used as a solvent for the production of flavors and fragrances in the food and cosmetics industries.
N-methyl pyrrolidinone is used as a reaction solvent in the synthesis of surfactants, which are used in detergents and personal care products.

N-methyl pyrrolidinone is a solvent for resins used in the production of flooring materials, such as vinyl and linoleum.
N-methyl pyrrolidinone is used as a solvent for the production of polyamide fibers, such as nylon.

N-methyl pyrrolidinone is used in the production of various chemicals, including pharmaceuticals, agrochemicals, and polymers.
N-methyl pyrrolidinone is a common solvent in the production of polyvinylidene fluoride and other polymers.

N-methyl pyrrolidinone is used in the purification of natural gas and refinery gas streams.
N-methyl pyrrolidinone is used as a co-solvent in printing ink formulations.

N-methyl pyrrolidinone is commonly used in the production of lithium-ion batteries.
N-methyl pyrrolidinone is used in the purification of certain types of biogas.
N-methyl pyrrolidinone is used as a solvent in the production of pesticides and herbicides.

N-methyl pyrrolidinone is commonly used in the production of electronics and semiconductors.
N-methyl pyrrolidinone is used in the production of coatings and adhesives.

N-methyl pyrrolidinone is used as a solvent in the production of dyes and pigments.
N-methyl pyrrolidinone is used in the production of cleaning and degreasing products.

N-methyl pyrrolidinone is used in the production of acrylic fibers and films.
N-methyl pyrrolidinone is used as a solvent in the production of flavors and fragrances.

N-methyl pyrrolidinone is used in the production of magnetic tape.
N-methyl pyrrolidinone is used in the production of photographic film and paper.

N-methyl pyrrolidinone is used in the production of surfactants.
N-methyl pyrrolidinone is used in the production of resins and plasticizers.
N-methyl pyrrolidinone is used in the production of synthetic fibers, such as nylon.

N-methyl pyrrolidinone is used in the production of rubber products.
N-methyl pyrrolidinone is used as a solvent in the production of food additives and preservatives.

N-methyl pyrrolidinone is used in the production of pharmaceutical intermediates.
N-methyl pyrrolidinone is used in the production of veterinary medicines.

N-methyl pyrrolidinone is used in the production of flavors and fragrances for the cosmetic industry.
N-methyl pyrrolidinone is used in the production of automotive parts.
N-methyl pyrrolidinone is used in the production of printing plates for the graphic arts industry.

DESCRIPTION

N-methyl pyrrolidinone (NMP) is a highly versatile organic solvent with the chemical formula C5H9NO.
N-methyl pyrrolidinone is a colorless to pale yellow liquid that is soluble in water and most organic solvents.
N-methyl pyrrolidinone is widely used in various industrial applications due to its unique properties, including high boiling point, low vapor pressure, good solvency, and excellent chemical stability.

N-methyl pyrrolidinone is commonly used in the production of electronics, pharmaceuticals, and polymers, as well as in the extraction of petrochemicals and natural gas.
N-methyl pyrrolidinone is also used as a solvent in the manufacturing of coatings, paints, and adhesives.
N-methyl pyrrolidinone has a relatively low toxicity and is considered safe for most industrial uses, although prolonged or repeated exposure may cause irritation to the skin, eyes, and respiratory tract.

N-methyl pyrrolidinone is a highly versatile organic solvent with a wide range of industrial applications.
N-methyl pyrrolidinone is a colorless to pale yellow liquid that is soluble in water and most organic solvents.

N-methyl pyrrolidinone has a high boiling point and low vapor pressure, making it useful in high-temperature applications.
N-methyl pyrrolidinone has excellent solvency properties, allowing it to dissolve a wide range of organic and inorganic substances.
N-methyl pyrrolidinone is widely used in the production of electronics, pharmaceuticals, and polymers.

N-methyl pyrrolidinone is a popular solvent for the extraction of petrochemicals and natural gas.
N-methyl pyrrolidinone is used in the manufacturing of coatings, paints, and adhesives.

N-methyl pyrrolidinone has a low toxicity and is considered safe for most industrial uses.
N-methyl pyrrolidinone is highly stable and does not react with many other chemicals.

N-methyl pyrrolidinone is a polar solvent that can dissolve both polar and nonpolar substances.
N-methyl pyrrolidinone has a relatively slow evaporation rate, making it useful in applications requiring long exposure times.

N-methyl pyrrolidinone has a slightly sweet odor and a mild taste.
N-methyl pyrrolidinone is not flammable and does not pose a significant fire hazard.
N-methyl pyrrolidinone is used in the production of lithium-ion batteries, which power many electronic devices.

N-methyl pyrrolidinone is used as a solvent in the manufacture of pharmaceuticals such as antibiotics and antifungal agents.
N-methyl pyrrolidinone is a key component in the production of polyvinylpyrrolidone (PVP), a common polymer used in a wide range of applications.

N-methyl pyrrolidinone is used in the production of synthetic fibers such as aramid and carbon fibers.
N-methyl pyrrolidinone is used as a solvent in the manufacture of printed circuit boards (PCBs).

N-methyl pyrrolidinone is used as a solvent in the production of graphene and other nanomaterials.
N-methyl pyrrolidinone is used in the manufacture of resins, such as epoxy resins, which are widely used in the construction industry.
N-methyl pyrrolidinone is used as a solvent in the extraction of metals from ores and other raw materials.

N-methyl pyrrolidinone is used in the production of agrochemicals, such as herbicides and insecticides.
N-methyl pyrrolidinone is used in the production of rubber and plastics.

N-methyl pyrrolidinone is used in the formulation of personal care products such as shampoos and lotions.
N-methyl pyrrolidinone is used as a solvent in the printing industry, where it is used to clean printing plates and equipment.

PROPERTIES

Physical properties:

Molecular formula: C5H9NO
Molecular weight: 99.13 g/mol
Appearance: clear, colorless to pale yellow liquid
Odor: amine-like
Melting point: -24 °C (-11 °F)
Boiling point: 202 °C (396 °F)
Density: 1.028 g/mL at 25 °C (77 °F)
Vapor pressure: 0.11 kPa (25 °C)
Solubility: miscible in water, ethanol, acetone, benzene, and other organic solvents
Flash point: 95 °C (203 °F)

Chemical properties:

N-methyl pyrrolidinone is a polar aprotic solvent.
N-methyl pyrrolidinone is hygroscopic and can absorb water from the atmosphere.
N-methyl pyrrolidinone can undergo hydrogen bonding with other polar compounds.

N-methyl pyrrolidinone can react with oxidizing agents to form potentially explosive compounds.
N-methyl pyrrolidinone can react with acids to form salts.
N-methyl pyrrolidinone can be hydrolyzed under acidic or basic conditions.

N-methyl pyrrolidinone can participate in various types of chemical reactions, including substitution, addition, and elimination reactions.
N-methyl pyrrolidinone is stable under normal storage conditions.

Toxicological properties:

N-methyl pyrrolidinone is classified as a reproductive toxin and a skin sensitizer.
N-methyl pyrrolidinone can cause skin and eye irritation upon contact.
Inhalation of N-methyl pyrrolidinone can cause respiratory irritation.

Prolonged or repeated exposure can cause damage to the liver and kidneys.
N-methyl pyrrolidinone is not classified as a carcinogen by the International Agency for Research on Cancer (IARC) or the US National Toxicology Program (NTP).
N-methyl pyrrolidinone has a low potential to bioaccumulate in aquatic organisms.

Environmental properties:

N-methyl pyrrolidinone is moderately persistent in the environment.
N-methyl pyrrolidinone can be degraded by microorganisms and by some chemical processes.
N-methyl pyrrolidinone has low to moderate mobility in soil, depending on the soil type.

N-methyl pyrrolidinone has a low potential to leach into groundwater.
N-methyl pyrrolidinone is not expected to accumulate in sediment or bioconcentrate in aquatic organisms.
N-methyl pyrrolidinone is not classified as an ozone-depleting substance or a greenhouse gas.

FIRST AID

Here are some first aid measures that should be taken in case of exposure to N-methyl pyrrolidinone:

Inhalation:

Move the affected person to an area with fresh air.
If the person is not breathing, perform artificial respiration.
Seek medical attention immediately.

Skin contact:

Remove contaminated clothing and rinse the affected area with plenty of water.
If the chemical has been absorbed through the skin or if skin irritation occurs, seek medical attention.

Eye contact:

Rinse eyes with water for several minutes, lifting upper and lower eyelids occasionally.
Seek medical attention if eye irritation persists.

Ingestion:

Do not induce vomiting unless directed to do so by a medical professional.
Rinse the mouth with water and seek medical attention immediately.
Note: Never give anything by mouth to an unconscious person.

Other measures:

If large amounts of N-methyl pyrrolidinone are spilled or released, evacuate the area and notify the appropriate authorities.
Wear appropriate protective equipment, such as gloves and eye protection, when handling the chemical.
Store and handle the chemical in a well-ventilated area away from sources of heat or ignition.

HANDLING AND STORAGE

Handling:

Use the chemical in a well-ventilated area.
Wear appropriate protective equipment, such as gloves and eye protection, when handling the chemical.

Avoid contact with skin, eyes, and clothing.
Do not eat, drink, or smoke while handling the chemical.

Storage:

Store N-methyl pyrrolidinone in a cool, dry, well-ventilated area away from sources of heat or ignition.
Keep containers tightly closed and upright to prevent leaks or spills.
Store the chemical away from incompatible materials, such as strong oxidizing agents.

Store the chemical in a secure area to prevent unauthorized access.
Follow all local and national regulations for the storage of hazardous materials.

Note: Always refer to the specific safety data sheet (SDS) for N-methyl pyrrolidinone for detailed handling and storage instructions.

SYNONYMS

1-Methyl-2-pyrrolidinone
NMP
N-methyl-2-pyrrolidinone
1-methyl-5-azacyclooctan-2-one
N-methylpyrrolidone
N-methyltetrahydro-2H-pyrrole-2-one
1-Methyl-5-pyrrolidin-2-one
Pyrrolidin-2-one, 1-methyl-
1-Methyl-2-pyrrolidone
NSC 88585
UNII-95TI6B3ANO
AC1L1QZM
AI3-52427
AKOS006269523
BRN 1104832
CCRIS 7320
CHEBI:8195
CHEMBL39423
DTXSID0026601
EINECS 203-296-1
LS-102790
MFCD00003168
NSC88585
SBB056620
STL239285
1-Methyl-5-pyrrolidone-2
2-Pyrrolidinone, 1-methyl-
5-Methyl-2-pyrrolidone
Alpha-n-methylpyrrolidone
Dipolar aprotic solvent
N-Methyl-2-pyrrolidon
N-Methyl-2-pyrrolidonum
N-Methyl-γ-pyrrolidone
N-Methyl-γ-pyrrolidon
N-Methyl-γ-valerolactam
N-Methyl-5-azacyclooctan-2-one
N-Methylpyrrolidonum
N-Methyltetrahydro-2-pyrrole-2-one
NMPR
Pyrrolidone, 1-methyl-2-
1-Methyl-5-oxo-pyrrolidine-2
2-Pyrrolidone, N-methyl-
5-Pyrrolidone-2, 1-methyl
5-Pyrrolidone-2, N-methyl-
AKOS015904012
AKOS027099352
ANW-42391
AS-12391
BC206080
C11045
FEMA No. 3725
Hexahydro-1-methyl-5H-1,3-diazin-5-one
M-Pyrol
M-Pyrol®
Methylpyrrolidinone
MPD
N-Methyl-2-pyrrolidone
N-Methylbutyrolactam
N-Methylvalerolactam
N-Methylpyrrolidine-2-one
N-MP
N-OMP
N-Methylbutyramide
N-Methyl-γ-butyrolactam
N-Methyl-γ-valerolactone
NSC 656593
Pyrrolidin-2-one, 1-methyl-
Pyrrolidone, 1-methyl-
Pyrrolidone, N-methyl-
UNII-95F2C2G85B
1-Methyl-5-pyrrolidone-2-carboxamide
2-Pyrrolidone, 1-methyl-, (S)-
5-Methyl-2-pyrrolidinone
AK104126

N-Methyl Pyrrolidinone is a natural product found in Microtropis japonica, Melicope hayesii, and other organisms with data available.
N-Methyl Pyrrolidinone appears as a clear colorless liquid
N-Methyl Pyrrolidinone has a "fishlike" odor

CAS NUMBER: 872-50-4

EC NUMBER: 212-828-1

MOLECULAR FORMULA: C5H9NO

MOLECULAR WEIGHT: 99.13

IUPAC NAME: 1-methylpyrrolidin-2-one

N-Methyl Pyrrolidinone is denser than water.
N-Methyl Pyrrolidinone's flash point is 199 °F.

N-Methyl Pyrrolidinone is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.
N-Methyl Pyrrolidinone has a role as a polar aprotic solvent.

N-Methyl Pyrrolidinone is used in the following products:
-pH regulators
-water treatment products
-laboratory chemicals

N-Methyl Pyrrolidinone is used in the following areas:
-scientific research and development
-agriculture
-forestry
-fishing and formulation of mixtures and/or re-packaging

N-Methyl Pyrrolidinone is used for the manufacture of: chemicals.
N-Methyl Pyrrolidinone is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones.

USAGE:
-liquids/detergents
-automotive care products
-paints
-coating or adhesives
-fragrances and air fresheners
-outdoor use
-indoor use in close systems
-cooling liquids in refrigerators
-oil-based electric heaters
-outdoor use in close systems
-hydraulic liquids in automotive suspension
-lubricants in motor oil and break fluids

N-Methyl Pyrrolidinone is a substance used as a pH regulator.
N-Methyl Pyrrolidinone is included in the content of water treatment products.

N-Methyl Pyrrolidinone is a compound used in the synthesis of some laboratory chemicals.
N-Methyl Pyrrolidinone aids scientific research and development

N-Methyl Pyrrolidinone is used in agriculture, forestry and fisheries applications
N-Methyl Pyrrolidinone can be used in some chemical processes

N-Methyl Pyrrolidinone is used for indoor use
N-Methyl Pyrrolidinone is found in paints and coatings

N-Methyl Pyrrolidinone is found in adhesives.
N-Methyl Pyrrolidinone is widely used in the automotive industry

N-Methyl Pyrrolidinone can be found in metal surface treatment products
N-Methyl Pyrrolidinone is used in the manufacture of polymers and coating products.

N-Methyl Pyrrolidinone is used in:
-semiconductors
-washing and cleaning products
-metal surface treatment products
-non-metal surface treatment products
-formulation of mixtures
-manufacture of electrical, electronic and optical equipment

N-methyl pyrrolidinone (NMP) is a powerful, aprotic solvent with high solvency and low volatility.
N-Methyl Pyrrolidinone is colorless

N-Methyl Pyrrolidinone has high boiling point and point
N-Methyl Pyrrolidinone has low vapor pressure

N-Methyl Pyrrolidinone has a mild amine-like odor.
N-Methyl Pyrrolidinone has high chemical and thermal stability and is completely miscible with water at all temperatures.

N-Methyl Pyrrolidinone is a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons.
N-Methyl Pyrrolidinone is both recyclable by distillation and readily biodegradable

PHYSICAL PROPERTIES:

-Molecular Weight: 99.13

-XLogP3: -0.5

-Exact Mass: 99.068413911

-Monoisotopic Mass: 99.068413911

-Topological Polar Surface Area: 20.3 Å²

-Physical Description: clear colorless liquid with a fish-like odor

-Color: Colorless

-Form: Liquid

-Odor: Mild amine odor

-Boiling Point: 202 °C

-Melting Point: -25 °C

-Flash Point: 96 °C

-Solubility: Miscible with water

-Density: 1.03

-Vapor Density: 3.4

-Vapor Pressure: 0.34 mmHg

-Autoignition Temperature: 245 °C

-Viscosity: 1.65 cP

-Surface Tension: 40.7 dynes/cm

N-Methyl Pyrrolidinone is an essential solvent for fluorinated coatings.
N-Methyl Pyrrolidinone is a very slow-evaporating solvent.

N-Methyl Pyrrolidinone is a solvent for agricultural formulations and synthesis applications such as insecticides, fungicides, and herbicides.
N-Methyl Pyrrolidinone solvent, a lower alkyl pyrrolidone, is a potent and versatile aprotic solvent.

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 0

-Hydrogen Bond Acceptor Count: 1

-Rotatable Bond Count: 0

-Heavy Atom Count: 7

-Formal Charge: 0

-Complexity: 90.1

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

-Chemical Classes: Solvents -> Other Solvents

N-Methyl Pyrrolidinone's high boiling point, low vapor pressure, and high stability make it an effective solvent in numerous industrial applications.
N-Methyl Pyrrolidinone can be used as a co-solvent with water, alcohol, and other organic substances.

N-Methyl Pyrrolidinone solvent is highly resistant to hydrolysis from pH 2-10, even at elevated temperatures.
N-Methyl Pyrrolidinone is a versatile water-miscible polar aprotic solvent.

N-Methyl Pyrrolidinone is freely soluble in polar and nonpolar solvents and should readily cross biological membranes.
N-Methyl Pyrrolidinone is quickly absorbed from human skin and gastrointestinal and respiratory tracts.

N-Methyl Pyrrolidinone is a stable solvent
N-Methyl Pyrrolidinone can undergo a number of chemical reactions.

N-Methyl Pyrrolidinone is resistant to hydrolysis under neutral conditions.
N-Methyl Pyrrolidinone can be reduced to 1-methyl pyrrolidine by borohydride.

N-Methyl Pyrrolidinone is colorless
N-Methyl Pyrrolidinone is light yellow liquid with amine odor

N-Methyl Pyrrolidinone is a versatile industrial solvent.
N-Methyl Pyrrolidinone is miscible with water and most common organic solvents.

N-Methyl Pyrrolidinone is used as a solvent in the petrochemical and plastics industries
N-Methyl Pyrrolidinone is non-volatile
N-Methyl Pyrrolidinone has the ability to dissolve various materials

N-Methyl Pyrrolidinone is denser than water.
N-Methyl Pyrrolidinone has a role as a polar aprotic solvent.

N-Methyl Pyrrolidinone is used in laboratory chemicals
N-Methyl Pyrrolidinone is used for the manufacture of: chemicals.

N-Methyl Pyrrolidinone is used in agriculture, forestry and fisheries applications
N-Methyl Pyrrolidinone can be used in some chemical processes

N-Methyl Pyrrolidinone is widely used in the automotive industry
N-Methyl Pyrrolidinone can be found in metal surface treatment products

N-Methyl Pyrrolidinone is used in the manufacture of polymers and coating products.
N-Methyl Pyrrolidinone is used in metal surface treatment products

N-Methyl Pyrrolidinone is colorless
N-Methyl Pyrrolidinone has a mild amine-like odor.

SYNONYMS:

1-METHYL-2-PYRROLIDINONE
872-50-4
N-Methylpyrrolidone
N-Methyl-2-pyrrolidone
1-methylpyrrolidin-2-one
Methylpyrrolidone
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidinone
M-Pyrol
N-Methylpyrrolidinone
1-Methylpyrrolidinone
1-Methylpyrrolidone
Methyl pyrrolidone
n-methyl-pyrrolidone
2-Pyrrolidinone, 1-methyl-
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
N-methylpyrrolidin-2-one
NMP
N-Methyl-gamma-butyrolactam
N-methyl pyrrolidone
1-methylpyrrolidine-2-one
N-methyl pyrrolidinone
Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidon
Methylpyrrolidinone
2-Pyrrolidinone, methyl-
Methylpyrrolidone
N-Methylpyrrolid-2-one
N-Methyl-alpha-pyrrolidinone
1-methyl-pyrrolidin-2-one
N-Methyl-.alpha.-pyrrolidone
N-Methyl-.gamma.-butyrolactam
N-Methyl-.alpha.-pyrrolidinone
1-Methyl-2-pyrrolidinone, anhydrous
1-Methyl-2-pyrrolidinone
N 0131
26876-92-6
pharmasolve
N-Methylpyrrolidon
CAS-872-50-4
CCRIS 1633
N-methyl-pyrrolidinone
Methylpyrrolidone, N-
Pyrrolidinone, methyl-
N-Methyl-2-pyrrolidon
1-methyl-2-pyrolidone
EINECS 212-828-1
N-methyl-pyrrolidin-2-one
AI3-23116
N-methylpyrolidone
N-methypyrrolidone
Max-1 peptide
Pyrol M
N-methylpirrolidone
1methylpyrrolidinone
n-methyl pyrrolidon
n-methylbutyrolactam
N-methy pyrrolidone
N-methyl-pyrolidone
N-methyl-pyrrolidon
N-methylpyrolidinone
1-methylpyrolidinone
Microposit 2001
n-methylpyrollidinone
N-Methylpyrrolidione
N-methlypyrrolidinone
N-methyl pirrolidone
N-methyl pyrollidone
N-methyl-pyrollidone
N-methylpyrrolidone-
1-methyl pyrrolidone
1-methyl-pyrrolidone
methyl-2-pyrrolidone
N-methy pyrrolidinone
N-methyl pyrolidinone
N-methyl-pyrolidinone
N-methyl- pyrrolidone
N-methylpyrro-lidinone
N-methylpyrroli-dinone
N-methylpyrrolidin-one
1-methyl-pyrrolidinone
methylpyrrolidin-2-one
N-methy-2-pyrrolidone
N-methyl 2-pyrolidone
N-methyl-2-pyrolidone
3p1d
N-methyl 2-pyrrolidone
N-methyl-2-pyrollidone
1-methyl-2-pirrolidone
1-methyl-2-pyroldinone
1-methylpyrrolid-2-one
1methyl-2-pyrrolidinone
n-methylpyrrolidine-2one
N-methyl-2-pyrolidinone
N-methyl-2-pyrrolidinon
N-methylpyrolidin-2-one
1-methy-2-pyrrolidinone
1-methyl-2-pyrolidinone
N-methyl 2-pyrrolidinone
N-methyl-2-pyrollidinone
N-methyl-pyrrolid-2-one
N-methylpyrollidin-2-one
1 -methyl-2-pyrrolidone
1-methyl 2-pyrrolidinone
1-methyl-2-pyrollidinone
1-methyl-pyrrolin-2-one
N-Methylpyrrolidone-(2)
NMP, N-Methylpyrrolidone
1-Methyl-pyrrolidin-2one
N-methylpyrrolidine-2-one
N-methyl -2-pyrrolidinone
1 -methyl-2-pyrrolidinone
1-methyl -2-pyrrolidinone
1-methyl-2- pyrrolidinone
EC 212-828-1
2-Pyrrolidone, 1-methyl-
1-methyl-pyrrolidine-2-one
1-N-methyl-2-pyrrolidinone
N-methyl-pyrrolidin -2-one
30207-69-3
1-Methylazacyclopentane-2-one
GTPL9520
METHYL PYRROLIDONE [II]
1-Methyl-2- pyrrolidin-2-one
1-METHYLPYRROLIDONE [MI]
METHYL PYRROLIDONE [INCI]
METHYLPYRROLIDONE
N-METHYLPYRROLIDONE
1-Methyl-2-pyrrolidinone, 99.5%
N-Methyl pyrrolidon
N-METHYLPYRROLIDONE
1-METHYL-2-PYRROLIDINONE
N-METHYLPYRROLIDONE
-PYRROLIDONE,1-METHYL MFC5 H9 N1 O1
A842053
1-Methyl-2-pyrrolidinone
2,5-Dichloro-4,6-dimethyl pyridine-3-carbonitrile
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone
Methylpyrrolidone
N-Methylpyrrolidone
1-Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone (NMP)
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylpyrrolidin-2-one
1-Methylpyrrolidinone
1-Methylpyrrolidone
2-Pyrrolidinone, 1-methyl-
AgsolEx 1
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
n-Methyl-2-pyrrolidone
N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone
1-mehyl-2-pyrrolodone
1-Methyl 2-pyrrolidone
1-methyl 2-pyrrolidone
1-Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidon
1-Methyl-2-Pyrrolidone
1-Methyl-2-pyrrolidone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone
1-methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone (NMP)
1-methylpyrrolidin-1-one
1-methylpyrrolidin-2-one
1-methylpyrrolidin-2-one,N-METHYLPYRROLIDONE, 1-Methyl-2-pyrrolidinone, N-METHYL-2-PYRROLIDONE
1-methylpyrrolidone
1-méthyl-2-pyrrolidone
1-O-butyl 2-O-(phenylmethyl) benzene-1,2-dicarboxylate
2-Pyrrolidinone, 1-methyl-
2-Pyrrolidone, 1-methyl
Methyl pyrrolidone
METHYL-N 2-PYRROLIDONE
n methyl 2 pyrrolidone
N-Methyl pyrolidone
N-methyl-2-pyrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidon
N-METHYL-2-PYRROLIDONE
N-Methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
n-methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone
N-Methylpyrrolidone
N-Methylpyrrolidone
NMP
NMP
NMP (n-methyl-2-pyrrolidone)

n-Methyl-2-pyrrolidone (NMP) is a highly polar aprotic solvent with the chemical formula C5H9NO.
n-Methyl-2-pyrrolidone is a colorless to light yellow liquid with a slightly amine-like odor.
n-Methyl-2-pyrrolidone is also known by its IUPAC name, N-methylpyrrolidone.

CAS Number: 872-50-4
EC Number: 212-828-1

APPLICATIONS

n-Methyl-2-pyrrolidone is commonly used as a solvent for various applications.
n-Methyl-2-pyrrolidone is used as a cleaning agent in the electronics industry.
n-Methyl-2-pyrrolidone is used as a solvent in the production of pharmaceuticals and agrochemicals.

n-Methyl-2-pyrrolidone is used as a reaction medium in chemical synthesis.
n-Methyl-2-pyrrolidone is used in the production of polymer fibers, films, and coatings.

n-Methyl-2-pyrrolidone is used as a solvent in the production of lithium-ion batteries.
n-Methyl-2-pyrrolidone is used in the production of photoresist materials.

n-Methyl-2-pyrrolidone is used as a solvent in the extraction of oil and gas.
n-Methyl-2-pyrrolidone is used in the production of printing inks and dyes.
n-Methyl-2-pyrrolidone is used in the production of adhesives and sealants.

n-Methyl-2-pyrrolidone is used as a solvent in the production of paints and coatings.
n-Methyl-2-pyrrolidone is used as a stripping agent in the semiconductor industry.

n-Methyl-2-pyrrolidone is used in the production of flavors and fragrances.
n-Methyl-2-pyrrolidone is used as a solvent in the production of herbicides and insecticides.

n-Methyl-2-pyrrolidone is used as a reaction solvent in the production of fine chemicals.
n-Methyl-2-pyrrolidone is used as a wetting agent in the production of ceramics.

n-Methyl-2-pyrrolidone is used in the production of electrolytes for lithium-ion batteries.
n-Methyl-2-pyrrolidone is used as a solvent in the production of water treatment chemicals.
n-Methyl-2-pyrrolidone is used in the production of resins and polymers.

n-Methyl-2-pyrrolidone is used as a solvent in the production of metal coatings.
n-Methyl-2-pyrrolidone is used as a reaction solvent in the production of pharmaceutical intermediates.

n-Methyl-2-pyrrolidone is used in the production of specialty chemicals.
n-Methyl-2-pyrrolidone is used as a solvent in the production of fuel additives.

n-Methyl-2-pyrrolidone is used in the production of food additives.
n-Methyl-2-pyrrolidone is used as a reaction solvent in the production of agrochemical intermediates.
n-Methyl-2-pyrrolidone is widely used as a solvent in various industries, including electronics, pharmaceuticals, and petrochemicals.

n-Methyl-2-pyrrolidone is used as a solvent in the production of polymers, resins, and coatings.
n-Methyl-2-pyrrolidone is a popular solvent for the manufacture of lithium-ion batteries.

n-Methyl-2-pyrrolidone is also used in the production of polyvinyl chloride (PVC) and other thermoplastic resins.
n-Methyl-2-pyrrolidone is used in the production of polyurethane foam and coatings.

n-Methyl-2-pyrrolidone is also used as a solvent in the production of pharmaceuticals, such as antibiotics and anti-inflammatory drugs.
n-Methyl-2-pyrrolidone is a commonly used solvent for the purification of proteins and nucleic acids.
n-Methyl-2-pyrrolidone is used in the extraction of natural products and flavors from plant materials.

n-Methyl-2-pyrrolidone is used in the production of pesticides, herbicides, and other agrochemicals.
n-Methyl-2-pyrrolidone is used in the textile industry as a dyeing and finishing agent.

n-Methyl-2-pyrrolidone is used as a solvent in the printing industry, particularly for the production of high-quality prints.
n-Methyl-2-pyrrolidone is used as a cleaning solvent for various industrial equipment and machinery.

n-Methyl-2-pyrrolidone is used as a solvent for the synthesis of organic compounds, such as pharmaceutical intermediates and specialty chemicals.
n-Methyl-2-pyrrolidone is used as a lubricant in metalworking and machining applications.
n-Methyl-2-pyrrolidone is used in the production of adhesives and sealants.

n-Methyl-2-pyrrolidone is a commonly used solvent for the cleaning and maintenance of electronic components and devices.
n-Methyl-2-pyrrolidone is used as a co-solvent in water-based coatings and inks.

n-Methyl-2-pyrrolidone is used as a reaction medium in various chemical reactions, such as polymerization and hydrogenation.
n-Methyl-2-pyrrolidone is used as a solvent for the formulation of personal care and cosmetic products.
n-Methyl-2-pyrrolidone is used as a carrier solvent for various flavors and fragrances.

n-Methyl-2-pyrrolidone is used in the production of photoresist materials for the semiconductor industry.
n-Methyl-2-pyrrolidone is used as a solvent for the production of graphene and other advanced materials.

n-Methyl-2-pyrrolidone is used in the production of specialty chemicals, such as surfactants and detergents.
n-Methyl-2-pyrrolidone is used as a solvent for the extraction and separation of rare earth elements.
n-Methyl-2-pyrrolidone is used in the production of inkjet inks and toners.

n-Methyl-2-pyrrolidone (NMP) is a versatile chemical that has many applications in various industries.
Some of its common applications include:

Solvent:

n-Methyl-2-pyrrolidone is used as a solvent for many chemicals, including polymers, resins, and dyes.

Pharmaceutical industry:

n-Methyl-2-pyrrolidone is used as a solvent and a carrier for drugs.

Electronics industry:

n-Methyl-2-pyrrolidone is used as a cleaning agent for electronic components.

Polymer industry:

n-Methyl-2-pyrrolidone is used as a solvent for polymerization reactions and as a dispersant for pigments and fillers.

Paint and coating industry:

n-Methyl-2-pyrrolidone is used as a solvent for resins, pigments, and additives in paints and coatings.

Adhesive industry:

n-Methyl-2-pyrrolidone is used as a solvent and a carrier for adhesives.

Chemical processing:

n-Methyl-2-pyrrolidone is used in chemical reactions, such as esterification, amidation, and hydrogenation.

Lithium-ion battery production:

n-Methyl-2-pyrrolidone is used as a solvent for the electrode materials and the electrolyte in lithium-ion batteries.

Petrochemical industry:

n-Methyl-2-pyrrolidone is used as a solvent for the separation of various chemicals in the petrochemical industry.

Textile industry:

n-Methyl-2-pyrrolidone is used as a solvent and a dye carrier in the textile industry.

Agriculture industry:

n-Methyl-2-pyrrolidone is used as a solvent for agricultural chemicals, such as pesticides and herbicides.

Printing industry:

n-Methyl-2-pyrrolidone is used as a solvent for inks and coatings in the printing industry.

Film industry:

n-Methyl-2-pyrrolidone is used as a solvent for film coatings and as a plasticizer for film materials.

Cleaning industry:

n-Methyl-2-pyrrolidone is used as a solvent for cleaning products.

Cosmetics industry:

n-Methyl-2-pyrrolidone is used as a solvent for cosmetic products, such as lotions and creams.

Food industry:

n-Methyl-2-pyrrolidone is used as a solvent for flavor and fragrance ingredients.

Rubber industry:

n-Methyl-2-pyrrolidone is used as a solvent for rubber and as a dispersant for fillers.

Textile printing industry:

n-Methyl-2-pyrrolidone is used as a solvent for textile printing pastes.

Water treatment industry:

n-Methyl-2-pyrrolidone is used as a solvent for water treatment chemicals.

Wood industry:

n-Methyl-2-pyrrolidone is used as a solvent for wood preservatives.

Gas processing industry:

n-Methyl-2-pyrrolidone is used as a solvent for natural gas processing.

Aerospace industry:

n-Methyl-2-pyrrolidone is used as a solvent for cleaning and degreasing aerospace components.

Automotive industry:

n-Methyl-2-pyrrolidone is used as a solvent for cleaning and degreasing automotive components.

Coating industry:

n-Methyl-2-pyrrolidone is used as a solvent for coatings and adhesives.

Construction industry:

n-Methyl-2-pyrrolidone is used as a solvent for construction chemicals, such as adhesives and sealants.

n-Methyl-2-pyrrolidone is used as a solvent in a wide range of industries, including pharmaceuticals, electronics, and coatings.
n-Methyl-2-pyrrolidone is an effective solvent for many organic and inorganic compounds, making it useful in a variety of chemical reactions and manufacturing processes.
n-Methyl-2-pyrrolidone is often used as a cleaning agent and degreaser due to its ability to dissolve oils and greases.

n-Methyl-2-pyrrolidone is used as a solvent in the production of polymers and resins, such as polyvinyl chloride and polyurethane.
n-Methyl-2-pyrrolidone is a common ingredient in paint strippers and graffiti removers due to its ability to dissolve and remove coatings and adhesives.

n-Methyl-2-pyrrolidone is used in the production of pharmaceuticals, including as a solvent for drug delivery systems and as a reactant in chemical syntheses.
n-Methyl-2-pyrrolidone is used as a solvent in the production of microelectronics and semiconductors.
n-Methyl-2-pyrrolidone is used in the production of rechargeable batteries and lithium-ion batteries.

n-Methyl-2-pyrrolidone is used in the production of high-performance fibers and films, such as those used in bulletproof vests and window films.
n-Methyl-2-pyrrolidone is used as a solvent in the production of flavors and fragrances.

n-Methyl-2-pyrrolidone is used in the production of pesticides and herbicides, as well as in the formulation of insect repellents.
n-Methyl-2-pyrrolidone is used as a solvent and extractant in the production of natural products, such as essential oils and plant extracts.

n-Methyl-2-pyrrolidone is used in the production of adhesives and sealants, as well as in the formulation of caulks and sealants.
n-Methyl-2-pyrrolidone is used in the production of printing inks and toners.

n-Methyl-2-pyrrolidone is used in the production of surfactants and detergents.
n-Methyl-2-pyrrolidone is used as a solvent in the production of photographic chemicals and film.
n-Methyl-2-pyrrolidone is used in the production of rubber and elastomers.

n-Methyl-2-pyrrolidone is used as a solvent in the production of flavors and fragrances.
n-Methyl-2-pyrrolidone is used as a cleaning agent and degreaser in the automotive industry.

n-Methyl-2-pyrrolidone is used in the production of industrial lubricants and hydraulic fluids.
n-Methyl-2-pyrrolidone is used as a solvent in the production of personal care products, such as shampoos and lotions.

n-Methyl-2-pyrrolidone is used as a solvent in the production of cleaning products, such as household cleaners and disinfectants.
n-Methyl-2-pyrrolidone is used in the production of food additives, such as emulsifiers and stabilizers.

n-Methyl-2-pyrrolidone is used as a solvent in the production of textile and leather chemicals, such as dyes and tanning agents.
n-Methyl-2-pyrrolidone is used as a solvent in the production of construction chemicals, such as concrete additives and sealers.

DESCRIPTION

n-Methyl-2-pyrrolidone (NMP) is a highly polar aprotic solvent with the chemical formula C5H9NO.
n-Methyl-2-pyrrolidone is a colorless to light yellow liquid with a slightly amine-like odor.
n-Methyl-2-pyrrolidone is also known by its IUPAC name, N-methylpyrrolidone.

n-Methyl-2-pyrrolidone is a clear and colorless to pale yellow liquid.
n-Methyl-2-pyrrolidone is a highly polar solvent with a high boiling point.
n-Methyl-2-pyrrolidone has a slightly amine-like odor and a bitter taste.

n-Methyl-2-pyrrolidone is miscible with water and many organic solvents.
n-Methyl-2-pyrrolidone is a versatile solvent used in various industries.

n-Methyl-2-pyrrolidone is commonly used in the production of electronics, pharmaceuticals, and polymers.
n-Methyl-2-pyrrolidone is a strong solvent for many organic compounds.

n-Methyl-2-pyrrolidone is also used as a solvent for dyes, resins, and pesticides.
The high polarity of n-Methyl-2-pyrrolidone makes it an excellent choice for dissolving polymers and plastics.
n-Methyl-2-pyrrolidone has a low vapor pressure, which makes it useful in high-temperature processes.

n-Methyl-2-pyrrolidone is also used as a co-solvent to improve the solubility of other solvents.
n-Methyl-2-pyrrolidone is considered a safer alternative to many chlorinated solvents.
n-Methyl-2-pyrrolidone has a high boiling point of 202°C, which makes it useful for high-temperature applications.

n-Methyl-2-pyrrolidone is also used as a cleaning agent for metal surfaces and electronic components.
n-Methyl-2-pyrrolidone is a key ingredient in the production of lithium-ion batteries.

n-Methyl-2-pyrrolidone is also used in the production of synthetic fibers, such as nylon and spandex.
n-Methyl-2-pyrrolidone is a common ingredient in paint strippers and varnish removers.

n-Methyl-2-pyrrolidone is also used as a solvent in the production of agrochemicals and herbicides.
The solvent properties of n-Methyl-2-pyrrolidone make it useful in the production of adhesives and sealants.
n-Methyl-2-pyrrolidone is also used as a solvent in the printing industry.

n-Methyl-2-pyrrolidone is used as a solvent for the extraction of chemicals and pharmaceuticals.
n-Methyl-2-pyrrolidone is an excellent solvent for certain proteins and enzymes.

n-Methyl-2-pyrrolidone is also used in the production of carbon fibers and other high-performance materials.
n-Methyl-2-pyrrolidone is considered a low-toxicity solvent with a good safety profile.
n-Methyl-2-pyrrolidone is an important solvent in many industrial applications.

PROPERTIES

Chemical formula: C5H9NO
Molecular weight: 99.13 g/mol
Physical state: clear, colorless to slightly yellow liquid
Odor: amine-like
Melting point: -24.6 °C (-12.3 °F)
Boiling point: 202 °C (396 °F)
Density: 1.027 g/cm3 at 25 °C (77 °F)
Solubility: miscible with water, alcohols, ethers, ketones, and many organic solvents
Viscosity: 3.8 cP at 25 °C (77 °F)
Vapor pressure: 0.6 mmHg at 25 °C (77 °F)
Flash point: 94 °C (201 °F)
Autoignition temperature: 485 °C (905 °F)
Refractive index: 1.466 at 20 °C (68 °F)
Dielectric constant: 32.7 at 25 °C (77 °F)
Surface tension: 34.8 mN/m at 20 °C (68 °F)
Heat of vaporization: 43.2 kJ/mol at normal boiling point
Heat of combustion: -3.33 MJ/mol
pH: neutral (pH 7)
Acidity: low
Basicity: low
Toxicity: low acute toxicity, but can cause skin and eye irritation, and may be harmful if ingested or inhaled
Flammability: combustible liquid
Reactivity: stable under normal conditions, but may react with strong oxidizing agents and acids
Miscibility with water: complete
Hygroscopicity: absorbs moisture from air.

FIRST AID

Inhalation:

Move the person to fresh air immediately.
If the person is not breathing, administer artificial respiration and seek immediate medical attention.

If breathing is difficult, give oxygen and seek immediate medical attention.
Do not give anything by mouth to an unconscious person.

Skin Contact:

Remove any contaminated clothing and rinse the affected area thoroughly with water for at least 15 minutes.
If irritation occurs or persists, seek medical attention immediately.
Wash contaminated clothing thoroughly before reuse.

Eye Contact:

Immediately flush the eyes with plenty of water for at least 15 minutes, lifting the upper and lower eyelids occasionally.
Seek immediate medical attention if eye irritation persists.

Ingestion:

Rinse mouth and lips thoroughly with water.
Do not induce vomiting unless directed to do so by medical personnel.
Seek immediate medical attention.
Never give anything by mouth to an unconscious person.

General First Aid Measures:

Remove contaminated clothing and wash it before reuse.
Always wash hands thoroughly after handling n-Methyl-2-pyrrolidone.
If exposed to the substance, it is important to seek medical attention immediately, especially if any symptoms are present.

HANDLING AND STORAGE

Handling:

Wear suitable protective clothing, gloves, and eye/face protection.
Avoid contact with skin, eyes, and clothing.
Use in a well-ventilated area.

Keep away from sources of ignition.
Avoid inhalation of vapors and spray.

Use only in areas with appropriate exhaust ventilation.
Do not eat, drink, or smoke while using the chemical.
Wash hands thoroughly with soap and water after handling.

Storage:

Store in a cool, dry, and well-ventilated area.
Keep away from heat, sparks, open flames, and other sources of ignition.

Keep containers tightly closed and properly labeled.
Store away from oxidizing agents, acids, and reducing agents.
Keep containers away from direct sunlight.

Store separately from food and animal feed.
Store in a secure area away from children and unauthorized personnel.
Do not store near combustible materials.

SYNONYMS

NMP
1-Methyl-2-pyrrolidinone
M-Pyrol
N-Methylpyrrolidone
N-Methyl-2-pyrrolidine
1-Methyl-2-pyrrolidine
1-Methylpyrrolidin-2-one
N-Methyl-2-pyrrolidone, monosodium salt
N-Methyl-2-pyrrolidone, disodium salt
N-Methyl-2-pyrrolidone, trisodium salt
N-Methyl-2-pyrrolidone, potassium salt
N-Methyl-2-pyrrolidone, lithium salt
N-Methyl-2-pyrrolidone, cesium salt
N-Methyl-2-pyrrolidone, rubidium salt
N-Methyl-2-pyrrolidone, calcium salt
N-Methyl-2-pyrrolidone, magnesium salt
N-Methyl-2-pyrrolidone, barium salt
N-Methyl-2-pyrrolidone, zinc salt
N-Methyl-2-pyrrolidone, copper salt
N-Methyl-2-pyrrolidone, aluminum salt
N-Methyl-2-pyrrolidone, iron salt
N-Methyl-2-pyrrolidone, nickel salt
N-Methyl-2-pyrrolidone, cobalt salt
N-Methyl-2-pyrrolidone, silver salt
N-Methyl-2-pyrrolidone, gold salt
1-Methyl-2-pyrrolidinone
N-Methylpyrrolidone
NMP
Pyrrolidone, 1-methyl-2-
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidine
Methylpyrrolidone
NSC 8796
CCRIS 5086
FEMA 3715
BRN 1207953
AI3-02923
LS-59436
AKOS003644230
DSSTox_CID_7847
1-Methylpyrrolidin-2-one
1-Methyl-2-pyrrolidone
N-Methylpyrrolidin-2-one
M-Pyrol
M-Pyrol 100
Dow NMP
NMP-Solvent
Cytosol 200
Cyclomethylonone
1-Methyl-2-pyrrolidinone
N-Methylpyrrolidone
N-Methylpyrrolidinone
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidine
N-Methylpyrrolidine-2-one
M-Pyrol
NSC 62786
Pharmasolve
Reomax
Solvitose
Suvarose
UNII-95TI3G3A3K
1-Methyl-2-pyrrolidinonum
2-Pyrrolidinone, 1-methyl
5-Methyl-4-pyrrolidone
Bionolve MP
Dow MP
EINECS 211-443-9
Ketasolve
MP 200
M-Pyrol MP
N-Methylbutyrolactam
Pyrrolidone N-methyl

N-Methyl-2-pyrrolidone is an organic compound consisting of a 5-membered lactam.
N-Methyl-2-pyrrolidone is a colorless liquid, although impure samples can appear yellow.
N-Methyl-2-pyrrolidone is miscible with water and with most common organic solvents.

CAS Number: 872-50-4
EC Number: 212-828-1
MDL number: MFCD00003193
Chemical formula: C5H9NO

N-Methyl-2-pyrrolidone also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-Methyl-2-pyrrolidone is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).
N-Methylpyrrolidone, also known as NMP or 1-methyl-2-pyrrolidone).

N-Methyl-2-pyrrolidone produced is an aprotic, highly polar organic solvent used in a variety of industries and applications.
N-Methyl-2-pyrrolidone is highly hygroscopic and easily absorbs moisture in the air.
N-Methyl-2-pyrrolidone is chemically inactive and non-corrosive to other metals such as carbon steel and aluminum, except for copper.
N-Methyl-2-pyrrolidone is a polar solvent with outstanding characteristics.

N-Methyl-2-pyrrolidone has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.
N-Methyl-2-pyrrolidone is a 5-member-ring compound containing nitrogen.
N-Methyl-2-pyrrolidone has a wide range of uses due to the following excellent characteristics.

N-Methyl-2-pyrrolidone is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).
Organic and inorganic substances are highly soluble in it.
N-Methyl-2-pyrrolidone mixes with water in all proportions.

N-Methyl-2-pyrrolidone has a high flash point compared to similar solvents.
The boiling point is high, the freezing point is low, and handling is easy.
N-Methyl-2-pyrrolidone is chemically and thermally stable, and not corrosive.
N-Methyl-2-pyrrolidone applications in the electronics field have expanded in recent years.

N-Methyl-2-pyrrolidone's high polarity and high solvency power along with our high purity, high-grade production technology enable the high performance needed in this field.
N-Methyl-2-pyrrolidone can dissolve organic and inorganic compounds equally well or better than chlorofluorocarbon solvents.
N-Methyl-2-pyrrolidone is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

N-Methyl-2-Pyrrolidone is a pale yellow organic compound and is a non-flammable product.
N-Methyl-2-pyrrolidone is miscible with water and most other solvents, always test a little and see how it mixes.
N-Methyl-2-pyrrolidone is denser than water at 1.03g/cc with a boiling range of 56 ºC.
N-Methyl-2-pyrrolidone is a flammable organic liquid consisting of a 5-membered lactam.

N-Methyl-2-pyrrolidone is available in various quantities and reagent grades, it is a dipolar aprotic solvent with petrochemical, plastic, and pharmaceutical applications.
N-methyl-2-pyrrolidone (NMP-EL), powerful, aprotic solvent.
N-Methyl-2-pyrrolidone has high solvency, low volatility, high boiling, high flash point and low vapor pressure.

N-Methyl-2-pyrrolidone is a liquid carries a mild amine-like odor.
N-Methyl-2-pyrrolidone shows high chemical and thermal stability, miscible with water at all temperatures.
The global N-Methyl-2-pyrrolidone Market size was estimated at USD 1.07 billion in 2015 and is expected to witness significant growth over the forecast period, primarily owing to the rising demand from key application segments, such as oil & gas (petrochemical), pharmaceuticals and electronics, among others.

This growth can be attributed to the expansion of the overall petrochemical industry.
During the period 2017 - 2021, the spending on downstream asset maintenance is expected to witness a growth of 7%, compared to that in 2012 - 2016, to reach USD 336 billion.
This growth can be attributed to greenfield and brownfield expansion projects.

Asia Pacific and North America together account for more than 60% of this spending.
Such a huge expansion in the petrochemical industry will certainly boost the demand for N-Methyl-2-pyrrolidone over the forecast period.
N-Methyl-2-pyrrolidone is a common solvent and drug vehicle.
More recently N-Methyl-2-pyrrolidone has been identified as a candidate bromodomain ligand with antineoplastic and immunomodulatory activity.

Mechanistically N-Methyl-2-pyrrolidone appears to be a low-affinity, broad-spectrum acetyllysine mimetic, but with apparent comparable ligand efficiency to that of larger rationally developed compounds such as (+)-JQ1 because of its very low molecular weight.
N-Methyl-2-pyrrolidone, also know as 1-Methyl-2-pyrrolidone; N-Methylpyrrolidone; N-Methylpyrrolidinone.
N-Methyl-2-pyrrolidone is a polar solvent with high boiling point, low viscosity, high chemical and thermal stability.

N-Methyl-2-pyrrolidone has a good solvency for a wide range of inorganic and organic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.
N-Methyl-2-pyrrolidone belongs to the class of organic compounds known as n-alkylpyrrolidines.
N-Methyl-2-pyrrolidone is a versatile solubilizer for one-component systems.

N-Methyl-2-pyrrolidone is a water-miscible polar aprotic solvent with high interfacial activity.
N-Methyl-2-pyrrolidone is a high boiling, polar aprotic, low viscosity liquid.
N-Methyl-2-pyrrolidone has good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has high chemical and thermal stability.

N-Methyl-2-pyrrolidone is a polar aprotic solvent with similar solvent properties as DMF, DMA, and DMSO.
N-Methyl-2-pyrrolidone is miscible with water.
N-Methyl-2-pyrrolidone is a versatile industrial solvent.
The sum of import and export of N-Methyl-2-pyrrolidone in and into Europe is estimated to be between 10,000 and 100,000 tons.

USES and APPLICATIONS of N-METHYL-2-PYRROLIDONE:
N-Methyl-2-pyrrolidone is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-Methyl-2-pyrrolidone is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.
Its good solvency properties have led to N-Methyl-2-pyrrolidone's use to dissolve a wide range of polymers.

Specifically, N-Methyl-2-pyrrolidone is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-Methyl-2-pyrrolidone is also used as a solvent in the commercial preparation of polyphenylene sulfide.
In the pharmaceutical industry, N-Methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes.

N-Methyl-2-pyrrolidone is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because NMP has a unique ability to dissolve polyvinylidene fluoride binder.
Due to N-Methyl-2-pyrrolidone's toxicity and high boiling point, there is much effort to replace it in battery manufacturing with other solvent(s), like water.

N-Methyl-2-pyrrolidone is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of N-Methyl-2-pyrrolidone can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.

Release to the environment of N-Methyl-2-pyrrolidone can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
N-Methyl-2-pyrrolidone is used in the following products: metal surface treatment products, non-metal-surface treatment products, polymers and coating products.

Release to the environment of N-Methyl-2-pyrrolidone can occur from industrial use: formulation of mixtures and manufacturing of the substance.
N-Methyl-2-pyrrolidone is used in the following areas: scientific research and development, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.
N-Methyl-2-pyrrolidone is used for the manufacture of: chemicals.

Other release to the environment of N-Methyl-2-pyrrolidone is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

N-Methyl-2-pyrrolidone is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Other release to the environment of N-Methyl-2-pyrrolidone is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

N-Methyl-2-pyrrolidone can be found in complex articles, with no release intended: vehicles and vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).
N-Methyl-2-pyrrolidone is widespread used by professional workers.
N-Methyl-2-pyrrolidone is used in the following products: pH regulators and water treatment products and laboratory chemicals.

Therefore N-Methyl-2-pyrrolidone is used in various industrial fields as a cleaning or release agent.
N-Methyl-2-pyrrolidone is replacing 1,1,1-trichloroethane in metal cleaning applications due to the world-wide environmental pollution problems associated with chlorinated solvents.
N-Methyl-2-pyrrolidone is used to produce fine chemicals from mass-produced chemicals.

N-Methyl-2-pyrrolidone is used as a solvent for chemicals and resins in the microelectronics and pharmaceutical industries.
N-Methyl-2-pyrrolidone is widely used to replace other solvents, e.g., for paint stripping and lube oil extraction.
N-Methyl-2-pyrrolidone is used as a solvent for pesticides, coatings, adhesives, dyes, pigments, polymers, and polyurethane foam cleanup.

N-Methyl-2-pyrrolidone is a solvent used in a variety of industries and applications such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning, and industrial/ domestic cleaning.
Due to its good solvency properties, N-Methyl-2-pyrrolidone is used to dissolve a wide range of polymers.
N-Methyl-2-pyrrolidone is used in the surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.

N-Methyl-2-pyrrolidone is used solvent for resins, acetylene, etc.
N-Methyl-2-pyrrolidone is used Pigment dispersant, petroleum processing, spinning agent for polyvinyl chloride, microelectronics industry plastic solvent applications, intermediate.
N-Methyl-2-pyrrolidone, also known as NMP or 1-methyl-2-pyrrolidone, is a solvent used in a range of products.

N-Methyl-2-pyrrolidone is used in electronics industry, coatings (polyamide-imide, epoxy, and polyurethane).
The 99.9% high purity N-Methyl-2-pyrrolidone is widely used in battery research and industry as a solvent for binder, slurry coating and electrode materials preparation.

Other applications of N-Methyl-2-pyrrolidone can be found for engineering polymers and coating resins, paint cleaning, recovery of 1,3-butadiene and acetylene and hydrogen sulfide absorption.
N-Methyl-2-pyrrolidone is used as a drug solubilizer and penetration enhancer in human and animal parenteral dosage forms.
N-Methyl-2-pyrrolidone is used as a versatile industrial solvent.

N-Methyl-2-pyrrolidone is currently approved for use only in veterinary pharmaceuticals.
N-Methyl-2-pyrrolidone is used as solvent in the production of polymers, paints, semiconductor materials and batteries.
Another important field of use of N-Methyl-2-pyrrolidone is as cleaning agent to remove plastic, oil and paints.

N-Methyl-2-pyrrolidone is widely used in advanced lubricating oil refining, polymer synthesis, insulating materials, pesticides, pigments and cleaning agents.
N-Methyl-2-pyrrolidone is used as a solvent for engineering polymers and coating resins.
The polar nature and the low surface tension of N-Methyl-2-pyrrolidone makes it also an excellent cleaning medium and paint stripping solvent.

-Uses at industrial sites:
N-Methyl-2-pyrrolidone is used in the following products: semiconductors, washing & cleaning products, metal surface treatment products and non-metal-surface treatment products.
N-Methyl-2-pyrrolidone is used in the following areas: formulation of mixtures and/or re-packaging.

-Electronics use of N-Methyl-2-pyrrolidone:
*Wax, flux removal
*Burr removal
*Electronic parts cleaning
*Semiconductor parts cleaning
*Solvent for lithium battery manufacturing
*Semiconductor photo-resist thinner
*Color filter photo-resist thinner

-Automotive uses of N-Methyl-2-pyrrolidone:
*Mold cleaning
*Metal (parts) cleaning

-Chemical uses of N-Methyl-2-pyrrolidone:
*Extract agent (acetylene, BTX, butadiene)
*Synthetic resin surface coating solvent
*Reaction solvents (PPS, polyimide, etc.)
*Equipment washing

-Optical uses of N-Methyl-2-pyrrolidone:
*Plastic lens manufacturing equipment cleaning

-Pharmaceutical and Agricultural Chemicals use of N-Methyl-2-pyrrolidone:
*Water-soluble solvent
*Cleaning
*Extraction

-Cosmetic Uses of N-Methyl-2-pyrrolidone:
*solvents
*surfactants

WHAT PRODUCTS CONTAIN N-METHYL-2-PYRROLIDONE?
*Paint Strippers:
N-Methyl-2-pyrrolidone is a key ingredient in a variety of paint and coating removers sold in the U.S.

*Paints and other coatings:
N-Methyl-2-pyrrolidone is also used in a range of coating products sold by popular retailers.

*Other Products:
Some adhesives, cleaners, dyes, inks, and pesticides also contain N-Methyl-2-pyrrolidone.

PREPARATION OF N-METHYL-2-PYRROLIDONE:
N-Methyl-2-pyrrolidone is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 200,000 to 250,000 tons are produced annually.

ALTERNATIVE PARENTS OF N-METHYL-2-PYRROLIDONE:
*Pyrrolidine-2-ones
*Tertiary carboxylic acid amides
*Lactams
*Azacyclic compounds
*Organopnictogen compounds
*Organonitrogen compounds
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds

SUBSTITUENTS OF N-METHYL-2-PYRROLIDONE:
*Pyrrolidone
*2-pyrrolidone
*N-alkylpyrrolidine
*Tertiary carboxylic acid amide
*Carboxamide group
*Lactam
*Carboxylic acid derivative
*Azacycle
*Organic oxide
*Organopnictogen compound
*Organic oxygen compound
*Organic nitrogen compound
*Organooxygen compound
*Organonitrogen compound
*Carbonyl group
*Hydrocarbon derivative
*Aliphatic heteromonocyclic compound

COMPOUND TYPE N-METHYL-2-PYRROLIDONE:
*Amide
*Amine
*Household Toxin
*Industrial/Workplace Toxin
*Organic Compound
*Solvent
*Synthetic Compound

PHYSICAL and CHEMICAL PROPERTIES of N-METHYL-2-PYRROLIDONE:
Chemical formula: C5H9NO
Molar mass: 99.133 g·mol−1
Density: 1.028 g/cm3
Melting point: −24 °C (−11 °F; 249 K)
Boiling point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water: Soluble
Solubility in Ethanol, acetone, diethylether, ethyl acetate, chloroform, benzene: Soluble
log P: −0.40
Molecular Weight: 99.13
Boiling point: 202 °C (1013 hPa)
Density: 1.03 g/cm3 (25 °C)
Explosion limit: 1.3 - 9.5 %(V)
Flash point: 91 °C
Ignition temperature: 245 °C
Melting Point: -24.2 °C
pH value: 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure: 0.32 hPa (20 °C)
Solubility: 1000 g/l
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%

Density (g/ml) @ 20°C: 1.029-1.033
Refractive Index (20°C): 1.470-1.472
Boiling Range: 202-204°C
Water (KF): max. 0.1%
Boiling point: 202 °C (1013 hPa)
Density: 1.03 g/cm3 (25 °C)
Explosion limit: 1.3 - 9.5 %(V)
Flash point: 91 °C
Ignition temperature: 245 °C
Melting Point: -24.2 °C
pH value: 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure: 0.32 hPa (20 °C)
Solubility: 1000 g/l
Physical state: liquid
Colour: colourless - clear
Odour: faintly perceptible - like: - amine
Melting point/freezing point: -24,2 °C at 1.013 hPa (ECHA)
Boiling point or initial boiling point and boiling range: 204,3 °C at 1.016 hPa (ECHA)
Lower and upper explosion limit: 1,3 vol% (LEL) - 9,5 vol% (UEL)
Flash point: 91 °C at 1.013 hPa (ECHA)
Auto-ignition temperature: 251 °C at 1.013 hPa (ECHA)

Decomposition temperature: not relevant
pH: (value) 8,5 – 10 (in aqueous solution: 100 g/l, 20 °C)
Kinematic viscosity 1,613 mm²/s at 25 °C
Dynamic viscosity 1,661 mPa s at 25 °C
Solubility(ies): Water solubility 1.000 g/l at 20 °C (ECHA)
Partition coefficient:
Partition coefficient: n-octanol/water (log value): -0,46 (25 °C) (ECHA)
Soil organic carbon/water: (log KOC) 0,87 (ECHA)
Vapour pressure: 0,32 hPa at 20 °C 2,54 hPa at 50 °C
Density and/or relative density:
Density: 1,03 g /cm³ at 25 °C (ECHA)
Relative vapour density: 3,42 (air = 1)
Particle characteristics: not relevant (liquid)
Other safety parameters:
Oxidising properties: none
Other safety characteristics:
Miscibility: completely miscible with water
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.031
Refractive Index (20°C): 1.470-1.471
Boiling Range: 201-202°C
Non Volatile Matter: max. 0.0005%
Water (KF): max. 0.05%

Physical state and appearance: Liquid, colorless
Odour: Amine like
Odour Threshold: Not Available
Taste: Not Available
Color: Colourless or Light Yellow
pH (1% soln/Water): 7.7 – 8.0
Boiling Point: 202 °C / 395.6 °F @ 760 mmHg
Flash Point: 91 °C / 195.8 °F
Molecular Weight: 99.13 g/mol
Melting Point: -24 °C / -11.2 °F
Critical Temperature: 451°C (843.8°F)
Specific Gravity: 1.026 (Water = 1)
Vapor Pressure: 0 kPa (@ 20°C)
Vapor Density: 3.4 (Air = 1)
Vapor Pressure: 0.7 mbar @ 25 °C
Solubility: miscible
Autoignition Temperature: 346 °C / 654.8 °F
Viscosity: 1.67 mPa s at 20 °C
Other Information: Not Available
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -25.00 °C. @ 760.00 mm Hg
Boiling Point: 202.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.345000 mmHg @ 25.00 °C.
Vapor Density: 3.4 ( Air = 1 )
Flash Point: 187.00 °F. TCC ( 86.10 °C. )
logP (o/w): -0.380
Soluble in: water, 1.00E+06 mg/L @ 25 °C, water, 2.483e+005 mg/L @ 25 °C

Molecular Formula: C5H9NO
Molar Mass: 99.13
Density: 1.028 g/mL at 25 °C (lit.)
Melting Point: -24 °C (lit.)
Boling Point: 202 °C (lit.)81-82 °C/10 mmHg (lit.)
Flash Point: 187°F
Water Solubility: >=10 g/100 mL at 20 ºC
Solubility: ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
Vapor Presure: 0.29 mm Hg ( 20 °C)
Vapor Density: 3.4 (vs air)
Appearance: Liquid
Color: ≤20(APHA)
Odor: Slight amine odor
Maximum wavelength(λmax): ['283nm(MeOH)(lit.)']
Merck: 14,6117
BRN: 106420
pKa: -0.41±0.20(Predicted)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
Storage Condition: Store at +5°C to +30°C.
Stability: Stable, but decomposes upon exposure to light.
Sensitive: Hygroscopic
Explosive Limit: 1.3-9.5%(V)
Refractive Index: n20/D 1.479
Physical and Chemical Properties: Characteristics of colorless transparent oily liquid, slightly amine odor.
melting point: -24.4 ℃
boiling point: 203 ℃
relative density: 1.0260
refractive index: 1.486
flash point: 95 ℃

FIRST AID MEASURES of N-METHYL-2-PYRROLIDONE:
-Description of First Aid Measures:
*General information :
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*Eye Contact:
Check for and remove any contact lenses.
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes.
Get medical attention immediately.
*Skin Contact:
Wash with soap and water.
*Serious Skin Contact:
Not Available
*Inhalation:
If inhaled, remove to fresh air.
Get medical attention.
*Serious inhalation:
Not Available
*Swallowing:
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
Not Available

ACCIDENTAL RELEASE MEASURES of N-METHYL-2-PYRROLIDONE:
-Environmental precautions:
Do not let product enter drains.
-Methods and material for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of N-METHYL-2-PYRROLIDONE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further Information (Precautions):
Use water spray to cool unopened containers.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-METHYL-2-PYRROLIDONE:
-Control Parameters:
--Components with workplace control parameters:
-Exposure Controls:
--Appropriate Engineering Controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
--Personal Protective Equipment:
*Eye/face protection:
Safety glasses with side-shields.
*Skin protection:
Handle with gloves.
Wash and dry hands.
-Control of Environmental Exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-METHYL-2-PYRROLIDONE:
-Precautions for Safe Handling:
No smoking.
-Conditions for safe storage, including any incompatibilities:
Store it in cool place.
Keep container tightly closed in a dry and well-ventilated place.

STABILITY and REACTIVITY of N-METHYL-2-PYRROLIDONE:
-Reactivity:
This material is not reactive under normal ambient conditions.
-Chemical stability:
The material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

SYNONYMS:
1-Methylpyrrolidin-2-one
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone
N-Methylpyrrolidinone
Pharmasolve
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidone
NMP
M-Pyrol
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP
1-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylpyrrolidinone
2-Pyrrolidone, 1-methyl-
1-Methylazacyclopentane-2-one
1-Methylpyrrolidone
N-Methylpyrrolidone-(2)
N-Methylpyrrolid-2-one
Methylpyrrolidone
1-Methylazacyclopentan-2-one
Agsolex 1
N 0131
N-Methyl-gamma-butyrolactam
Micropure ultra
NSC 4594
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylpyrrolidinone
1-Methylpyrrolidone
2-Pyrrolidinone, 1-methyl-
M-Pyrol
Methylpyrrolidone
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methyl-gamma-butyrolactam
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP
Norleucine, 5-oxo-, DL
UN1993
NMP
N-methylpyrrolidinone
N-methyl-2-pyrrolinone
1-methyl-5-pyrrolidinone
methylpyrrolidone
N-methylpyrrolidone
composite constituent
1-Methyl-2-pyrrolidinone
1-Methylazacyclopentan-2-one
N-Methyl-alpha-pyrrolidinone
N-Methyl-alpha-pyrrolidone
N-Methyl-gamma-butyrolactam
NMP
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylpyrrolidone
AgsolEx 1
M-Pyrol
Microposit 2001
N 0131
N-Methyl-2-ketopyrrolidine
N-Methyl-γ-butyrolactam
N-Methylbutyrolactam
N-Methylpyrrolidone
NMP
NSC 4594
Pharmasolve
Pyrol M
SL 1332
N-methyl-2-pyrrolidone
NMP
NMP-T
NMP-EL
M-PYROL(R)
N-METHYLPYROLIDONE
N-Methylpyrrolidone
N-Methyl pyrrolidone
N-Methyl-pyrrolidone
N-METHYLPYRROLIDNONE
N-METHYLPYRROLIDINONE
1-Methyl-2-pyrrolidone
N-METHYLPYRROLID-2-ONE
N-Methyl-2-pyrrolidone
1-METHYL-2-PYRROLIDINONE
N-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone, anhydrous
N-Methyl-2-pyrrolidone Manufacturer
N-Methyl-2-pyrrolidinone 872-50-4 NMP
1-Methyl-2-pyrrolidinone 872-50-4 NMP
N-Methyl-2-pyrrolidinone
1-METHYL-2-PYRROLIDONE
REAGENT (ACS)1-METHYL-2-PYRROLIDONE
REAGENT (ACS)1-METHYL-2-PYRROLIDONE
REAGENT (ACS)
M-Pyrol
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone; NMP
1-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylpyrrolidinone
2-Pyrrolidone, 1-methyl-
1-Methylazacyclopentane-2-one
1-Methylpyrrolidone
N-Methylpyrrolidone-(2)
N-Methylpyrrolid-2-one
Methylpyrrolidone
1-Methylazacyclopentan-2-one
Agsolex 1
N 0131
N-Methyl-gamma-butyrolactam
Micropure ultra
NSC 4594

n-Methyl-2-Pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
n-Methyl-2-Pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water and with most common organic solvents.

CAS Number: 872-50-4
EC Number: 212-828-1
MDL number: MFCD00003193
Chemical formula: C5H9NO

n-Methyl-2-Pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
n-Methyl-2-Pyrrolidone (NMP) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

n-Methyl-2-Pyrrolidone (NMP) is a polar solvent with outstanding characteristics.
n-Methyl-2-Pyrrolidone (NMP) has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.

n-Methyl-2-Pyrrolidone (NMP) has a wide range of uses due to the following excellent characteristics.
n-Methyl-2-Pyrrolidone (NMP) is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).

n-Methyl-2-Pyrrolidone (NMP) is a 5-member-ring compound containing nitrogen.
Organic and inorganic substances are highly soluble in n-Methyl-2-Pyrrolidone (NMP).
n-Methyl-2-Pyrrolidone (NMP) mixes with water in all proportions.

n-Methyl-2-Pyrrolidone (NMP) has a high flash point compared to similar solvents.
The boiling point of n-Methyl-2-Pyrrolidone (NMP) is high, the freezing point is low, and handling is easy.
n-Methyl-2-Pyrrolidone (NMP) is chemically and thermally stable, and not corrosive.

n-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid.
n-Methyl-2-Pyrrolidone (NMP) has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.

n-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility.
This colorless, high boiling, high flash point and low vapor pressure liquid, n-Methyl-2-Pyrrolidone (NMP), carries a mild aminelike odor. n-Methyl-2-Pyrrolidone (NMP) has high chemical and thermal stability and is completely miscible with water at all temperatures.

n-Methyl-2-Pyrrolidone (NMP) is a common solvent and drug vehicle. More recently n-Methyl-2-Pyrrolidone (NMP) has been identified as a candidate bromodomain ligand with antineoplastic and immunomodulatory activity.
Mechanistically n-Methyl-2-Pyrrolidone (NMP) appears to be a low-affinity, broad-spectrum acetyllysine mimetic, but with apparent comparable ligand efficiency to that of larger rationally developed compounds such as (+)-JQ1 because of its very low molecular weight.

n-Methyl-2-Pyrrolidone (NMP) is a flammable organic liquid consisting of a 5-membered lactam.
Available in various quantities and reagent grades, n-Methyl-2-Pyrrolidone (NMP) is a dipolar aprotic solvent with petrochemical, plastic, and pharmaceutical applications.

n-Methyl-2-Pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
n-Methyl-2-Pyrrolidone (NMP) is a colorless liquid, although impure samples can appear yellow.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water and with most common organic solvents.

n-Methyl-2-Pyrrolidone (NMP) also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
n-Methyl-2-Pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
n-Methyl-2-Pyrrolidone (NMP) is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials.

n-Methyl-2-Pyrrolidone (NMP), also known as NMP or 1-methyl-2-pyrrolidone).
n-Methyl-2-Pyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as pain and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.

n-Methyl-2-Pyrrolidone (NMP) is produced and imported into the United States, with use estimated at over 184 million pounds per year.
EPA estimates that approximately 9 percent of total n-Methyl-2-Pyrrolidone (NMP) usage is for paint and coating removal products.
n-Methyl-2-Pyrrolidone (NMP), also known as NMP or 1-methyl-2-pyrrolidone, is a solvent used in a range of products.

The average consumer is most likely to encounter n-Methyl-2-Pyrrolidone (NMP) in paint strippers, even though safer alternatives exist.
n-Methyl-2-Pyrrolidone (NMP) has been closely linked to developmental impacts including miscarriages.
n-Methyl-2-Pyrrolidone (NMP) is a clear colorless liquid with a fish-like odor.

n-Methyl-2-Pyrrolidone (NMP) is a polar solvent with outstanding characteristics.
n-Methyl-2-Pyrrolidone (NMP) is a powerful solvent.
n-Methyl-2-Pyrrolidone (NMP) offers exceptional performance, broad solubility for resins, high chemical and thermal stability.

n-Methyl-2-Pyrrolidone (NMP) is recyclable by distillation, easily biodegradable and essentially non-toxic to aquatic life.
n-Methyl-2-Pyrrolidone (NMP) is completely soluble with water at all temperatures and is soluble with most organic solvents.
n-Methyl-2-Pyrrolidone (NMP) is a pale yellow organic compound.

n-Methyl-2-Pyrrolidone (NMP) is non-flammable.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water has a boiling range of 56ºC.
n-Methyl-2-Pyrrolidone (NMP), a lower alkyl pyrrolidone, is an extremely powerful and versatile aprotic solvent.

n-Methyl-2-Pyrrolidone (NMP) is extremely resistant to hydrolysis from pH 2-10, even at elevated temperatures.
Beyond these limits, hydrolysis to 4-(methylamino) butanoic acid occurs at a rate dependent on pH and temperature.
A large body of chemistry has been developed on the reactions of strong nucleophiles with n-Methyl-2-Pyrrolidone (NMP).

n-Methyl-2-Pyrrolidone (NMP) has a molecular formula of C5H9NO, and it is a colorless to light yellow transparent liquid with a slight ammonia odor.
n-Methyl-2-Pyrrolidone (NMP)'s boiling point is 204℃, flash point is 91℃, chroma HaZen≤25, refractive index N20D 1.468-1.471, density is 1.032-1.035.
n-Methyl-2-Pyrrolidone (NMP) is miscible in water at any ratio, it is soluble in ethanol, acetone, esters, halogenated hydrocarbons, aromatic hydrocarbons and other organic solvents, and it can completely mix with practically all solvents.

n-Methyl-2-Pyrrolidone (NMP) appears as a clear colorless liquid with a "fishlike" odor.
n-Methyl-2-Pyrrolidone (NMP) is denser than water.
The flash point of n-Methyl-2-Pyrrolidone (NMP) is 199°F.

n-Methyl-2-Pyrrolidone (NMP) is a clear colorless liquid with a fish-like odor.
n-Methyl-2-Pyrrolidone (NMP) is a pale yellow organic compound and is a non-flammable product.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water and most other solvents, always test a little and see how it mixes.

n-Methyl-2-Pyrrolidone (NMP) is denser than water at 1.03g/cc with a boiling range of 56 ºC.
n-Methyl-2-Pyrrolidone (NMP) is a polar aprotic solvent with similar solvent properties as DMF, DMA, and DMSO.
n-Methyl-2-Pyrrolidone (NMP) is miscible with water.

n-Methyl-2-Pyrrolidone (NMP) is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones.
n-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility.
n-Methyl-2-Pyrrolidone (NMP) carries a mild amine-like odor.

n-Methyl-2-Pyrrolidone (NMP) has high chemical and thermal stability and is completely miscible with water at all temperatures.
n-Methyl-2-Pyrrolidone (NMP) can serve as a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons.
n-Methyl-2-Pyrrolidone (NMP) is both recyclable by distillation and readily biodegradable.

n-Methyl-2-Pyrrolidone (NMP) is not found on the Hazardous Air Pollutants (HAPs) list of the 1990 Clean Air Act Amendments.
n-Methyl-2-Pyrrolidone (NMP) is soluble in water.
n-Methyl-2-Pyrrolidone (NMP) is non flammable.

n-Methyl-2-Pyrrolidone (NMP) has high solvency, low volatility, high boiling, high flash point and low vapor pressure.
n-Methyl-2-Pyrrolidone (NMP) has liquid carries a mild amine-like odor. n-Methyl-2-Pyrrolidone (NMP) shows high chemical and thermal stability, miscible with water at all temperatures.

n-Methyl-2-Pyrrolidone (NMP) is one of the best and most versatile solvents to dissolve compounds with low aqueous solubility.
n-Methyl-2-Pyrrolidone (NMP) is the preferred solvent for long-acting in-situ forming depots.
n-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent.

USES and APPLICATIONS of n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
n-Methyl-2-Pyrrolidone (NMP) is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.

Its good solvency properties have led to n-Methyl-2-Pyrrolidone (NMP)'s use to dissolve a wide range of polymers.
Specifically, n-Methyl-2-Pyrrolidone (NMP) is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
n-Methyl-2-Pyrrolidone (NMP) is also used as a solvent in the commercial preparation of polyphenylene sulfide.

In the pharmaceutical industry, n-Methyl-2-Pyrrolidone (NMP) is used in the formulation for drugs by both oral and transdermal delivery routes.
n-Methyl-2-Pyrrolidone (NMP) is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because NMP has a unique ability to dissolve polyvinylidene fluoride binder.

Due to n-Methyl-2-Pyrrolidone (NMP)'s high boiling point, there is much effort to replace it in battery manufacturing with other solvent(s), like water.
n-Methyl-2-Pyrrolidone (NMP) is used in graffiti removal, paint stripping, coat removal, oven cleaning and electronic cleaning.
n-Methyl-2-Pyrrolidone (NMP) is often used to dissolve a wide range of polymers.

n-Methyl-2-Pyrrolidone (NMP) is used in petrochemical processing, engineering plastic coatings and agricultural chemicals.
n-Methyl-2-Pyrrolidone (NMP) has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.

n-Methyl-2-Pyrrolidone (NMP) is a solvent used in a variety of industries and applications such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning, and industrial/ domestic cleaning.
Due to its good solvency properties, n-Methyl-2-Pyrrolidone (NMP) is used to dissolve a wide range of polymers.

n-Methyl-2-Pyrrolidone (NMP) is used in the surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
n-Methyl-2-Pyrrolidone (NMP) is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Other release to the environment of n-Methyl-2-Pyrrolidone (NMP) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).
n-Methyl-2-Pyrrolidone (NMP) can be found in complex articles, with no release intended: vehicles and vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).

n-Methyl-2-Pyrrolidone (NMP) is used in the following products: pH regulators and water treatment products and laboratory chemicals. n-Methyl-2-Pyrrolidone (NMP) is used in the following areas: scientific research and development, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.

Other release to the environment of n-Methyl-2-Pyrrolidone (NMP) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

n-Methyl-2-Pyrrolidone (NMP) is used for the manufacture of: chemicals.
n-Methyl-2-Pyrrolidone (NMP) is used in the following products: metal surface treatment products, non-metal-surface treatment products, polymers and coating products.

Release to the environment of n-Methyl-2-Pyrrolidone (NMP) can occur from industrial use: formulation of mixtures and manufacturing of the substance.
n-Methyl-2-Pyrrolidone (NMP) is used in the following products: semiconductors, washing & cleaning products, metal surface treatment products and non-metal-surface treatment products.

n-Methyl-2-Pyrrolidone (NMP) is used in the following areas: formulation of mixtures and/or re-packaging.
n-Methyl-2-Pyrrolidone (NMP) is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of n-Methyl-2-Pyrrolidone (NMP) can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.

Release to the environment of n-Methyl-2-Pyrrolidone (NMP) can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
n-Methyl-2-Pyrrolidone (NMP) is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).

n-Methyl-2-Pyrrolidone (NMP) is used Electronics, Paints & coatings, Polymer & plastic, Process solvents, Solvents/stripping agents, Wire wrappers.
n-Methyl-2-Pyrrolidone (NMP) is used as a solvent for engineering polymers and coating resins.
Additionally, the polar nature and the low surface tension of n-Methyl-2-Pyrrolidone (NMP) makes it an excellent cleaning medium and paint stripping solvent.

n-Methyl-2-Pyrrolidone (NMP) is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in.
Pharmaceuticals: n-Methyl-2-Pyrrolidone (NMP) can be used as solvent, extraction medium.
Industrial and household cleaning: n-Methyl-2-Pyrrolidone (NMP) is used for paint stripping, in graffiti removers, oven cleaners, in automotive and industrial cleaner formulations.

Agrochemicals: n-Methyl-2-Pyrrolidone (NMP) can be used as solvent during synthesis or as a formulation agent.
n-Methyl-2-Pyrrolidone (NMP) produced by Welinks is an aprotic, highly polar organic solvent used in a variety of industries and applications.
Due to its high solvency and low volatility, n-Methyl-2-Pyrrolidone (NMP) is used in automotive and industrial cleaners with solvents, including hydrocarbons, terpenes, propylene carbonate and propylene glycol ethers.

With its high boiling point, low vapor pressure and high stability, n-Methyl-2-Pyrrolidone (NMP) is an effective solvent in numerous industry applications and can be used as a co-solvent with water, alcohols, and other organic substances.
n-Methyl-2-Pyrrolidone (NMP) is also used as a reaction medium for polyamide-imide resins in wire coatings and as a solvent for urethanes and epoxies in water based coatings.

n-Methyl-2-Pyrrolidone (NMP) is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability.
n-Methyl-2-Pyrrolidone (NMP)is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins.

n-Methyl-2-Pyrrolidone (NMP) is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits.
n-Methyl-2-Pyrrolidone (NMP) can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze.

n-Methyl-2-Pyrrolidone (NMP) is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization.
n-Methyl-2-Pyrrolidone (NMP) is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization.

n-Methyl-2-Pyrrolidone (NMP) can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent.
n-Methyl-2-Pyrrolidone (NMP) is used in mediums for polymerization reactions such as engineering plastics and aramid fiber.

n-Methyl-2-Pyrrolidone (NMP) is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries.
high purity grade for ICP-MS detection.
n-Methyl-2-Pyrrolidone (NMP) is used for peptide synthesis.

n-Methyl-2-Pyrrolidone (NMP) is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials
n-Methyl-2-Pyrrolidone (NMP) is used Solvent for Lithium Battery Cathode Materials.

n-Methyl-2-Pyrrolidone (NMP) is an ideal solvent for the electronics industry and can be used in a wide range of ever growing applications.
n-Methyl-2-Pyrrolidone (NMP) is a versatile industrial solvent.
n-Methyl-2-Pyrrolidone (NMP) is currently approved for use only in veterinary pharmaceuticals.

n-Methyl-2-Pyrrolidone (NMP) is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations.
n-Methyl-2-Pyrrolidone (NMP) is used solvent for high-temperature resins; petrochemical processing, in the microelectronics fabrication industry, dyes and pigments, industrial and domestic cleaning compounds; agricultural and pharmaceutical formulations.

n-Methyl-2-Pyrrolidone (NMP) is a polar solvent that is used in organic chemistry and polymer chemistry.
Large scale applications of n-Methyl-2-Pyrrolidone (NMP) include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.

n-Methyl-2-Pyrrolidone (NMP) is useful for spectrophotometry, chromatography and ICP-MS detection.
n-Methyl-2-Pyrrolidone (NMP) is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.

n-Methyl-2-Pyrrolidone (NMP) has a role as a polar aprotic solvent.
n-Methyl-2-Pyrrolidone (NMP) is used in electronics industry, coatings (polyamide-imide, epoxy, and polyurethane).
n-Methyl-2-Pyrrolidone (NMP) has been approved as a solvent for slimicide application to food packaging materials.

n-Methyl-2-Pyrrolidone (NMP) is used as a general dipolar aprotic solvent, stable and unreactive.
n-Methyl-2-Pyrrolidone (NMP) is used for extraction of aromatic hydrocarbons from lubricating oils.
n-Methyl-2-Pyrrolidone (NMP) is used for carbon dioxide removal in ammonia generators.

n-Methyl-2-Pyrrolidone (NMP) is used as a solvent for polymerization reactions and polymers.
n-Methyl-2-Pyrrolidone (NMP) is used as a paint stripper.
n-Methyl-2-Pyrrolidone (NMP) is used for pesticide formulations.

Other non-industrial uses of n-Methyl-2-Pyrrolidone (NMP) are based on its properties as a dissociating solvent suitable for electrochemical and physical chemical studies.
Pharmaceutical applications make use of the properties of n-Methyl-2-Pyrrolidone (NMP) as a penetration enhancer for a more rapid transfer of substances through the skin.

-Petrochemical processing:
n-Methyl-2-Pyrrolidone (NMP) is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction, lube oil purification.

-Electronics:
n-Methyl-2-Pyrrolidone (NMP) is used as photoresist stripper, for defluxing, degreasing and cleaning.
n-Methyl-2-Pyrrolidone (NMP) is a solvent for the production of FCCL, polyamide/polyimide wire enamels, epoxy and polyurethane coatings.

WHAT PRODUCTS CONTAIN n-mETHYL-2-PYRROLIDONE (NMP):
*Paint Strippers:
n-Methyl-2-Pyrrolidone (NMP) is a key ingredient in a variety of paint and coating removers sold in the U.S.
*Paints and other coatings:
n-Methyl-2-Pyrrolidone (NMP) is also used in a range of coating products sold by popular retailers.
*Other Products:
Some adhesives, cleaners, dyes, inks, and pesticides also contain n-Methyl-2-Pyrrolidone (NMP).

PRODUCTION METHODS OF n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is manufactured by the reaction of buytrolactone with methylamine.
Other processes of n-Methyl-2-Pyrrolidone (NMP) include preparation by hydrogenation of solutions of maleic or succinic acids with methylamine.

CHEMICAL PROPERTIES OF n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is a colourless or light yellow liquid with an amine odour.
n-Methyl-2-Pyrrolidone (NMP) can undergo a number of chemical reactions even though it is accepted as a stable solvent.
n-Methyl-2-Pyrrolidone (NMP) is resistant to hydrolysis under neutral conditions, but strong acid or base treatment results in ring opening to 4-methyl aminobutyric acid.
n-Methyl-2-Pyrrolidone (NMP) can be reduced to 1-methyl pyrrolidine with borohydride.

REACTIVITY PROFILE OF n-mETHYL-2-PYRROLIDONE (NMP):
This amine, n-Methyl-2-Pyrrolidone (NMP), is a very mild chemical base.
n-Methyl-2-Pyrrolidone (NMP) does tend to neutralize acids to form salts plus water.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

FEATURES AND BENEFFITS OF n-mETHYL-2-PYRROLIDONE (NMP):
* high interfacial activity
* solubilizer and penetration enhancer in human and veterinary injectable dosage forms
* dissolves a variety of poorly soluble APIs

PREPARATION OF n-mETHYL-2-PYRROLIDONE (NMP):
n-Methyl-2-Pyrrolidone (NMP) is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 200,000 to 250,000 tons are produced annually.

STORAGE RECOMMENDATIONS OF n-mETHYL-2-PYRROLIDONE (NMP):
Keep n-Methyl-2-Pyrrolidone (NMP)t in a cool, dry, well-ventilated place, away from heat, ignition sources and incompatible substances.
n-Methyl-2-Pyrrolidone (NMP) should keep the container upright and tightly closed.
Physical damage to the container should be avoided.
Do not reuse the container.
Unwashed empty containers should be labelled as a warning.

PHYSICAL and CHEMICAL PROPERTIES of n-mETHYL-2-PYRROLIDONE (NMP):
Chemical formula: C5H9NO
Molar mass: 99.133 g·mol−1
Density: 1.028 g/cm3
Melting point: −24 °C (−11 °F; 249 K)
Boiling point: 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water: Soluble
Solubility in Ethanol, acetone, diethylether, ethyl acetate, chloroform, benzene: Soluble
log P: −0.40
Molecular Weight: 99.14
Appearance: Clear colorless liquid
Odor: Faint amine smell
Specific Gravity (25/4℃): 1.027
Viscosity(mPa･s) : 1.89（25℃）
Boiling Point (℃): 202
Freezing Point (℃): -23
Vapor specific gravity: 3.4
Flash Point (℃): 99 (open cup)
Autoignition Temperature (℃): 252
Physical state: clear, liquid
Color: colorless

Odor: amine-like
Melting point/freezing point:
Melting point/range: -24 °C
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 9,5 %(V)
Lower explosion limit: 1,3 %(V)
Flash point: 91 °C
Autoignition temperature :245 °C at 1.013 hPa - DIN 51794
Decomposition temperature: No data available
pH: 8,5 - 10,0 at 100 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 1,661 mPa.s at 25 °C
Water solubility: 1.000 g/l at 20 °C - soluble
Partition coefficient: n-octanol/water:
log Pow: -0,46 at 25 °C
Bioaccumulation is not expected.
Vapor pressure: 0,32 hPa at 20 °C
Density: 1,028 g/mL at 25 °C
Relative densit:y No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:

Conductivity: 0,2 - 0,4 µS/cm
Surface tension: 40,4 mN/m
Relative vapor density: 3,42 - (Air = 1.0)
Boiling point: 396°F
Molecular weight: 99.13
Freezing point/melting point: -9°F
Flash point: 204°F
Vapor density: 3.4
Specific gravity: 1.03
NFPA health rating: 2
NFPA fire rating: 2
NFPA reactivity rating: 0
Appearance (Clarity): Clear
Appearance (Colour): Colourless
Appearance (Form): Liquid
Assay (GC): min. 99.5%
Density (g/ml) @ 20°C: 1.029-1.033
Refractive Index (20°C): 1.470-1.472
Boiling Range: 202-204°C
Water (KF): max. 0.1%
Molecular Weight： 99.13110

Exact Mass： 99.13
EC Number： 212-828-1
UNII： JR9CE63FPM
ICSC Number： 0513
NSC Number： 4594
UN Number： 1993
DSSTox ID： DTXSID6020856
Color/Form： Clear liquid
HScode: 2933990090
PSA: 20.31000
XLogP3： 0.17650
Density： 1.027 g/cm3 @ Temp: 25 °C
Melting Point： -25 °C
Boiling Point： 202 °C @ Press: 760 Torr
Flash Point： 91ºC
Refractive Index： n20/D 1.479
Water Solubility： H2O: >=10 g/100 mL at 20 ºC
Storage Conditions： 2-8ºC
Vapor Pressure： 0.29 mm Hg ( 20 °C)
Vapor Density： 3.4 (vs air)
Explosive limit： vol% in air: 1.3.5
Odor： Mild amine odor
PH： pH = 7.7-8
Henrys Law Constant： 3.20e-09 atm-m3/mole
Experimental Properties：

Dipole moment at 25 °C: 4.09 debye
Dielectric constant at 25 °C: 32.3
Hydroxy radical rate constant = 7.4X10-11 cu cm/molecule-sec at 25 °C
Air and Water Reactions： Soluble in water.
Reactive Group： Amides and Imides
Autoignition Temperature： 655 °F (346 °C)|245 °C
Heat of Combustion： 719 kcal/mol
Heat of Vaporization： 127.3 kcal/Kg
Critical Temperature & Pressure：
Critical temperature = 451 °C
Critical pressure = 4.78 MPa
Empirical formula: C5H9NO
Molar mass (M): 99,13 g/mol
Density (D): 1,03 g/cm³
Boiling point (bp): 204,3 °C
Flash point (flp): 91 °C
Melting point (mp): -24,2 °C
CAS Number: 872-50-4
Molecular Weight: 99.13 g/mol
Appearance: Colorless liquid
Melting Point: -24 C
Boiling Point: 202 C
Density: 1.028 g/mL at 25 C

Melting point: -24 °C (lit.)
Boiling point: 202 °C (lit.) 81-82 °C/10 mmHg (lit.)
Density: 1.028 g/mL at 25 °C (lit.)
vapor density: 3.4 (vs air)
vapor pressure: 0.29 mm Hg ( 20 °C)
refractive index: n20/D 1.479
Flash point: 187 °F
storage temp.: Store at +5°C to +30°C.
solubility: ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
form: Liquid
pka: -0.41±0.20(Predicted)
color: ≤20(APHA)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
Odor: Slight amine odor
PH Range: 7.7 - 8.0
explosive limit: 1.3-9.5%(V)
Water Solubility: >=10 g/100 mL at 20 ºC
Sensitive: Hygroscopic
λmax: 283nm(MeOH)(lit.)
Merck: 14,6117
BRN: 106420
Stability: Stable, but decomposes upon exposure to light.
InChIKey: SECXISVLQFMRJM-UHFFFAOYSA-N
LogP: -0.46 at 25℃

FIRST AID MEASURES of n-mETHYL-2-PYRROLIDONE (NMP):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of n-mETHYL-2-PYRROLIDONE (NMP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of n-mETHYL-2-PYRROLIDONE (NMP):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of n-mETHYL-2-PYRROLIDONE (NMP):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: 60 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A-(P2)
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of n-mETHYL-2-PYRROLIDONE (NMP):
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
Take precautionary measures against static discharge.
*Hygiene measures:
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities
*Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.
Moisture sensitive.

STABILITY and REACTIVITY of n-mETHYL-2-PYRROLIDONE (NMP):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available

SYNONYMS:
1-Methylpyrrolidin-2-one
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone
N-Methylpyrrolidinone
Pharmasolve
G N-Methyl-2-Pyrrolidone,
1-Methyl-2-Pyrrolidone,
1-Methyl-Pyrrolidine-2-one,
N-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
N-Methyl-2-pyrrolidone
NMP
N-Methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone
NMP
M-PYROL
NMP; N-methylpyrrolidinone
N-methyl-2-pyrrolinone
1-methyl-5-pyrrolidinone
methylpyrrolidone
N-methylpyrrolidone
2-Pyrrolidinone,1-methyl-
2-Pyrrolidone,1-methyl-
1-Methyl-2-pyrrolidinone
N-Methylpyrrolidinone
1-Methyl-5-pyrrolidinone
NMP
N-Methyl-2-pyrrolidone
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methylpyrrolidone
M-Pyrol
1-Methylazacyclopentan-2-one
1-Methyl-2-pyrrolidone
Pyrol M
N-Methylpyrrolidone
AgsolEx 1
N 0131
Microposit 2001
N-Methyl-2-ketopyrrolidine
N-Methylbutyrolactam
Pharmasolve
SL 1332
NSC 4594
N-Methylpyrrolidine-2-one
M 0418
EKOS 1
NMP 1165
26138-58-9
53774-35-9
57762-46-6
M-Pyrol
N-Methyl-α-pyrrolidinone
N-Methyl-α-pyrrolidone
N-Methyl-γ-butyrolactam
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP
1-Methyl-2-Pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
1-Methylpyrrolidinone
2-Pyrrolidone, 1-methyl-
1-Methylazacyclopentane-2-one
1-Methylpyrrolidone
N-Methylpyrrolidone-(2)
N-Methylpyrrolid-2-one
Methylpyrrolidone
1-Methylazacyclopentan-2-one
Agsolex 1
N 0131
N-Methyl-gamma-butyrolactam
Micropure ultra
NSC 4594
NMP
N-METHYLPYRROLIDONE
1-METHYL-2-PYRROLIDINONE
1-methyl-pyrrolidin-2-one
1-METHYL-2-PYRROLIDONE
N-METHYL-2-PYRROLIDINONE
1-Methylpyrrolidin-2-one
N-METHYLPYRROLIDINON
Methylpyrrolidone
N-Methylpyrrolidon

DESCRIPTION:
N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam.
N-Methyl-2-pyrrolidone is a colorless liquid, although impure samples can appear yellow.
N-Methyl-2-pyrrolidone is miscible with water and with most common organic solvents.

CAS Number: 872-50-4
EINECS: No. 212-828-1

N-Methyl-2-pyrrolidone also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-Methyl-2-pyrrolidone is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF).

N-Methyl-2-pyrrolidone is a polar solvent with outstanding characteristics.
N-Methyl-2-pyrrolidone has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling.

N-Methyl-2-pyrrolidone is a 5-member-ring compound containing nitrogen.
N-Methyl-2-pyrrolidone has a wide range of uses due to the following excellent characteristics.

N-Methyl-2-pyrrolidone is highly polar and miscible with most organic solvents (alcohols, ethers, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, etc.).
Organic and inorganic substances are highly soluble in it.
N-Methyl-2-pyrrolidone mixes with water in all proportions.

N-Methyl-2-pyrrolidone has a high flash point compared to similar solvents.
The boiling point is high, the freezing point is low, and handling is easy.
N-Methyl-2-pyrrolidone is chemically and thermally stable, and not corrosive.

N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid.
NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.
N-Methyl-2-Pyrrolidone is used as a solvent for engineering polymers and coating resins.

Additionally, the polar nature and the low surface tension of N-Methyl-2-Pyrrolidone makes it an excellent cleaning medium and paint stripping solvent.
N-Methyl-2-Pyrrolidone is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in:

Petrochemical processing:
N-Methyl-2-Pyrrolidone is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction, lube oil purification.
As illustration for the strong selectivity of N-Methyl-2-Pyrrolidone towards acetylene, the table below shows the solubility of acetylene in various solvents.

PREPARATION OF N-METHYL-2-PYRROLIDONE:
NMP is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis. About 200,000 to 250,000 tons are produced annually.

APPLICATIONS OF N-METHYL-2-PYRROLIDONE:
NMP is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-Methyl-2-pyrrolidone is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.
Its good solvency properties have led to NMP's use to dissolve a wide range of polymers.

Specifically, it is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-Methyl-2-pyrrolidone is also used as a solvent in the commercial preparation of polyphenylene sulfide.
In the pharmaceutical industry, N-methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes.

N-Methyl-2-pyrrolidone is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, because NMP has a unique ability to dissolve polyvinylidene fluoride binder.
Due to NMP's toxicity and high boiling point, there is much effort to replace it in battery manufacturing with other solvent(s), like water.

BIOLOGICAL ASPECTS OF N-METHYL-2-PYRROLIDONE:
In rats, NMP is absorbed rapidly after inhalation, oral, and dermal administration, distributed throughout the organism, and eliminated mainly by hydroxylation to polar compounds, which are excreted via urine.
About 80% of the administered dose is excreted as NMP and NMP metabolites within 24 hours.
A probably dose dependent yellow coloration of the urine in rodents is observed.

The major metabolite is 5-hydroxy-N-methyl-2-pyrrolidone.
Studies in humans show comparable results.
Dermal penetration through human skin has been shown to be very rapid. NMP is rapidly biotransformed by hydroxylation to 5-hydroxy-N-methyl-2-pyrrolidone, which is further oxidized to N-methylsuccinimide; this intermediate is further hydroxylated to 2-hydroxy-N-methylsuccinimide.
These metabolites are all colourless.

The excreted amounts of NMP metabolites in the urine after inhalation or oral intake represented about 100% and 65% of the administered doses, respectively.
NMP has a low potential for skin irritation and a moderate potential for eye irritation in rabbits.
Repeated daily doses of 450 mg/kg body weight administered to the skin caused painful and severe haemorrhage and eschar formation in rabbits.

These adverse effects have not been seen in workers occupationally exposed to pure NMP, but they have been observed after dermal exposure to NMP used in cleaning processes.
No sensitization potential has been observed

APPLICATIONS OF N-METHYL-2-PYRROLIDONE:
N-methyl-2-pyrrolidone is used to produce fine chemicals from mass-produced chemicals.
N-methyl-2-pyrrolidone applications in the electronics field have expanded in recent years.
NMP's high polarity and high solvency power along with our high purity, high-grade production technology enable the high performance needed in this field.
NMP can dissolve organic and inorganic compounds equally well or better than chlorofluorocarbon solvents.

Therefore NMP is used in various industrial fields as a cleaning or release agent.
NMP is replacing 1,1,1-trichloroethane in metal cleaning applications due to the world-wide environmental pollution problems associated with chlorinated solvents.

1) Electronics:
• Wax, flux removal
• Burr removal
• Electronic parts cleaning
• Semiconductor parts cleaning
• Solvent for lithium battery manufacturing
• Semiconductor photo-resist thinner
• Color filter photo-resist thinner

2) Automotive:
• Mold cleaning
• Metal (parts) cleaning

3) Chemical:
• Extract agent (acetylene, BTX, butadiene)
• Synthetic resin surface coating solvent
• Reaction solvents (PPS, polyimide, etc.)
• Equipment washing

4) Optical:
• Plastic lens manufacturing equipment cleaning

5) Pharmaceutical and Agricultural Chemicals:
• Water-soluble solvent
• Cleaning
• Extraction

SAFETY INFORMATION ABOUT N-METHYL-2-PYRROLIDONE (NMP):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

CHEMICAL AND PHYSICAL PROPERTIES OF N-METHYL-2-PYRROLIDONE:
Chemical formula C5H9NO
Molar mass 99.133 g•mol−1
Density 1.028 g/cm3
Melting point −24 °C (−11 °F; 249 K)
Boiling point 202 to 204 °C (396 to 399 °F; 475 to 477 K)
Solubility in water Soluble
Solubility in Ethanol, acetone, diethylether, ethyl acetate, chloroform, benzene Soluble
log P −0.40
Common Names G N-Methyl-2-Pyrrolidone,
1-Methyl-2-Pyrrolidone,
1-Methyl-Pyrrolidine-2-one,
N-Methyl-2-Pyrrolidinone
Structure NMP
CAS　No. 872-50-4
Japan Chemical Mfg. Reg. 5-113
Japan, Fire Services Law Hazardous material Class 4 Petroleums No.3 water-soluble Hazardous Rank III
Molecular Weight 99.14
Appearance Clear colorless liquid
Odor Faint amine smell
Specific Gravity (25/4℃) 1.027
Viscosity(mPa･s) 1.89（25℃）
Boiling Point (℃) 202
Freezing Point (℃) -23
Vapor specific gravity 3.4
Flash Point (℃) 99 (open cup)
Autoignition Temperature (℃) 252
Hue (APHA) <50
Specific Gravity (20/4℃) 1.027～1.030
Purity (%) >99.0
Moisture (%) <0.1
Refractive index (ND25 ℃) 1.465～1.470
Distillation test
(℃) initial boiling point >198
Distillation test
dry point (℃) <208
Distillation test
all distillate volume (vol%) >95
CAS number 872-50-4
EC index number 606-021-00-7
EC number 212-828-1
Hill Formula C₅H₉NO
Molar Mass 99.13 g/mol
HS Code 2933 79 90
Boiling point 202 °C (1013 hPa)
Density 1.03 g/cm3 (25 °C)
Explosion limit 1.3 - 9.5 %(V)
Flash point 91 °C
Ignition temperature 245 °C
Melting Point -24.2 °C
pH value 8.5 - 10.0 (100 g/l, H₂O, 20 °C)
Vapor pressure 0.32 hPa (20 °C)
Solubility 1000 g/l
Purity (GC) ≥ 99.5 %
Identity (IR) conforms
Color ≤ 10 Hazen
Density (d 20 °C/ 4 °C) 1.031 - 1.033
Refractive index (n 20/D) 1.4680 - 1.4730
Acidity ≤ 0.0002 meq/g
Alkalinity ≤ 0.003 meq/g
Water ≤ 0.10 %
Appearance (Clarity) Clear
Appearance (Colour) Colourless
Appearance (Form) Liquid
Assay (GC) min. 99.5%
Density (g/ml) @ 20°C 1.029-1.033
Refractive Index (20°C) 1.470-1.472
Boiling Range 202-204°C
Water (KF) max. 0.1%

N-Methyl-2-pyrrolidone (NMP), also known simply as NMP, is a solvent and chemical intermediate with the molecular formula C5H9NO.
N-Methyl-2-pyrrolidone (NMP) is a colorless to slightly yellow liquid with a faint amine-like odor.
N-Methyl-2-pyrrolidone (NMP) is widely used in various industries due to its excellent solvency properties and versatile chemical reactivity.

CAS Number: 872-50-4
EC Number: 212-828-1

NMP, N-Methylpyrrolidone, 1-Methyl-2-pyrrolidinone, N-Methyl-2-pyrrolidinone, N-Methylpyrrolidinone, 1-Methylpyrrolidin-2-one, 1-Methyl-2-pyrrolidone, Methylpyrrolidinone, Methylpyrrolidone, Pyrrolidin-2-one, Methyl-pyrrolidinone, 1-Methylpyrrolidone, Methyl-pyrrolidone, Pyrrolidinone, N-Methylpyrrolidone, N-Methyl-pyrrolidone, Methylpyrrolidone, N-Methyl-2-pyrrolidone, N-Methyl-pyrrolidone, Pyrrolidone, 1-Methylpyrrolidone

APPLICATIONS

N-Methyl-2-pyrrolidone (NMP) is widely used as a solvent in various industrial processes.
N-Methyl-2-pyrrolidone (NMP) is commonly employed in the production of paints, coatings, and varnishes.
N-Methyl-2-pyrrolidone (NMP) serves as a solvent for resins, polymers, and adhesives, aiding in their formulation and application.

In the electronics industry, NMP is used for cleaning and degreasing electronic components and circuit boards.
N-Methyl-2-pyrrolidone (NMP) is an effective solvent for removing solder flux residues and other contaminants from electronic assemblies.

N-Methyl-2-pyrrolidone (NMP) is utilized in the pharmaceutical industry for drug delivery systems and formulation of pharmaceutical products.
N-Methyl-2-pyrrolidone (NMP) helps solubilize poorly soluble drugs and enhance their bioavailability in oral and topical formulations.

N-Methyl-2-pyrrolidone (NMP) is employed as a solvent in the production of agrochemicals such as pesticides and herbicides.
N-Methyl-2-pyrrolidone (NMP) aids in the formulation of agricultural products and enhances their efficacy and stability.

In the textile industry, NMP is used as a solvent for dyeing and printing processes.
N-Methyl-2-pyrrolidone (NMP) helps dissolve dyes and pigments and facilitates their penetration into fibers for uniform coloration.
N-Methyl-2-pyrrolidone (NMP) is utilized in the manufacture of synthetic fibers and films, contributing to their processing and quality.

N-Methyl-2-pyrrolidone (NMP) serves as a reaction medium in organic synthesis, enabling various chemical transformations.
N-Methyl-2-pyrrolidone (NMP) is employed in the production of specialty chemicals, flavors, and fragrances.

It is used in the formulation of cleaning agents and degreasers for industrial and household applications.
N-Methyl-2-pyrrolidone (NMP) is utilized as a solvent in the production of lithium-ion batteries for electrode coatings and electrolytes.
N-Methyl-2-pyrrolidone (NMP) helps dissolve lithium salts and conductive additives, improving battery performance and cycle life.

N-Methyl-2-pyrrolidone (NMP) is used in the formulation of personal care products such as cosmetics, lotions, and skincare products.
N-Methyl-2-pyrrolidone (NMP) aids in solubilizing active ingredients and enhancing product stability and texture.

In the automotive industry, NMP is utilized in the formulation of paints, coatings, and sealants for vehicle assembly.
N-Methyl-2-pyrrolidone (NMP) helps dissolve and disperse pigments and additives, ensuring uniform coverage and protection.

N-Methyl-2-pyrrolidone (NMP) is employed in the production of membranes for separation and purification processes.
N-Methyl-2-pyrrolidone (NMP) serves as a solvent for membrane casting and helps control membrane morphology and performance.

N-Methyl-2-pyrrolidone (NMP) is used in the manufacture of specialty films and laminates for packaging and industrial applications.
Overall, N-Methyl-2-pyrrolidone (NMP) finds diverse applications across industries, owing to its excellent solvency properties and chemical versatility.

N-Methyl-2-pyrrolidone (NMP) is utilized in the formulation of inkjet inks for digital printing applications.
N-Methyl-2-pyrrolidone (NMP) helps dissolve colorants and additives, resulting in high-quality prints with excellent color reproduction.
N-Methyl-2-pyrrolidone (NMP) is used as a solvent in the production of carbon fibers and composite materials.

N-Methyl-2-pyrrolidone (NMP) aids in the dispersion of carbon precursors and improves the quality and mechanical properties of the final products.
In the pharmaceutical industry, NMP is employed as a solvent for extraction and purification of active pharmaceutical ingredients (APIs).

N-Methyl-2-pyrrolidone (NMP) facilitates the isolation of compounds from natural sources and synthetic intermediates.
N-Methyl-2-pyrrolidone (NMP) is utilized in the formulation of industrial and household cleaning products such as degreasers and surface cleaners.
N-Methyl-2-pyrrolidone (NMP) effectively dissolves oils, greases, and stubborn residues, making it suitable for heavy-duty cleaning applications.

N-Methyl-2-pyrrolidone (NMP) is used as a carrier solvent in the formulation of agricultural pesticides and insecticides.
N-Methyl-2-pyrrolidone (NMP) helps disperse and stabilize active ingredients and enhances their penetration into plant tissues.

In the polymer industry, NMP is employed as a solvent for polymerization reactions and polymer processing.
N-Methyl-2-pyrrolidone (NMP) aids in the dissolution of polymer resins and additives, facilitating the production of high-performance materials.
N-Methyl-2-pyrrolidone (NMP) is utilized in the production of pharmaceutical excipients such as binders and solubilizers.

N-Methyl-2-pyrrolidone (NMP) helps improve the flow properties and compressibility of tablet formulations.
N-Methyl-2-pyrrolidone (NMP) is employed in the synthesis of specialty chemicals and intermediates for organic synthesis.

N-Methyl-2-pyrrolidone (NMP) serves as a versatile reagent in various chemical transformations, including amide bond formation and cyclization reactions.
N-Methyl-2-pyrrolidone (NMP) is used in the formulation of adhesive removers and paint strippers for industrial and consumer applications.

N-Methyl-2-pyrrolidone (NMP) helps dissolve and remove cured adhesives, paints, and coatings from substrates.
N-Methyl-2-pyrrolidone (NMP) is employed in the production of lubricants and metalworking fluids for industrial machining processes.
It serves as a carrier solvent for additives and lubricant components, improving machining performance and surface finish.

N-Methyl-2-pyrrolidone (NMP) is used in the formulation of sealants and caulks for construction and building applications.
N-Methyl-2-pyrrolidone (NMP) helps achieve proper rheology and adhesion properties in sealant formulations.
N-Methyl-2-pyrrolidone (NMP) is employed in the production of polymer membranes for gas separation and purification.

N-Methyl-2-pyrrolidone (NMP) serves as a solvent for membrane casting and helps control membrane morphology and pore size distribution.
Overall, N-Methyl-2-pyrrolidone (NMP) continues to find diverse applications across industries, demonstrating its versatility and utility as a solvent and chemical intermediate.

DESCRIPTION

N-Methyl-2-pyrrolidone (NMP), also known simply as NMP, is a solvent and chemical intermediate with the molecular formula C5H9NO.
N-Methyl-2-pyrrolidone (NMP) is a colorless to slightly yellow liquid with a faint amine-like odor.
N-Methyl-2-pyrrolidone (NMP) is widely used in various industries due to its excellent solvency properties and versatile chemical reactivity.

As a solvent, NMP is valued for its ability to dissolve a wide range of substances, including polymers, resins, oils, and pharmaceutical compounds.
N-Methyl-2-pyrrolidone (NMP) is commonly utilized in applications such as paint and coating formulations, cleaning agents, electronic materials, pharmaceuticals, and agrochemicals.

N-Methyl-2-pyrrolidone (NMP) is also employed as a reaction medium and chemical intermediate in organic synthesis.
N-Methyl-2-pyrrolidone (NMP) participates in various chemical reactions, including condensation, alkylation, and oxidation reactions, to produce a variety of organic compounds.
Additionally, NMP is used as a carrier solvent in chemical processes such as extraction and separation.

Despite its utility, NMP is known to have some health and environmental concerns.
N-Methyl-2-pyrrolidone (NMP) may cause skin and eye irritation upon contact and can be absorbed through the skin, potentially leading to systemic toxicity.

N-Methyl-2-pyrrolidone (NMP) is also classified as a reproductive toxicant and may have adverse effects on fertility and development.
Due to these risks, proper handling precautions, such as using personal protective equipment and implementing adequate ventilation, are necessary when working with NMP.

N-Methyl-2-pyrrolidone (NMP) is a colorless to slightly yellow liquid.
N-Methyl-2-pyrrolidone (NMP) has a molecular formula of C5H9NO.
The chemical structure of NMP consists of a pyrrolidone ring with a methyl group attached.

N-Methyl-2-pyrrolidone (NMP) has a faint amine-like odor.
N-Methyl-2-pyrrolidone (NMP) is soluble in water and many organic solvents.

N-Methyl-2-pyrrolidone (NMP) exhibits excellent solvency properties, making it a versatile solvent in various applications.
The boiling point of NMP is approximately 202°C, while its melting point is around -24°C.

N-Methyl-2-pyrrolidone (NMP) has a density of approximately 1.03 g/cm³ at 20°C.
N-Methyl-2-pyrrolidone (NMP) is hygroscopic, meaning it can absorb moisture from the atmosphere.

N-Methyl-2-pyrrolidone (NMP) is stable under normal conditions but may react with strong oxidizing agents.
N-Methyl-2-pyrrolidone (NMP) is commonly used in the production of paints, coatings, and adhesives.
N-Methyl-2-pyrrolidone (NMP) is also utilized as a solvent in the electronics industry for cleaning circuit boards and semiconductor devices.

N-Methyl-2-pyrrolidone (NMP) serves as a reaction medium in organic synthesis due to its ability to dissolve a wide range of organic compounds.
N-Methyl-2-pyrrolidone (NMP) is employed in pharmaceutical formulations for drug delivery and solubilization of active ingredients.

N-Methyl-2-pyrrolidone (NMP) is used in the production of polymers and resins, contributing to their processing and performance properties.
N-Methyl-2-pyrrolidone (NMP) can be found in consumer products such as cleaning agents and personal care products.
N-Methyl-2-pyrrolidone (NMP) is known for its high boiling point, which allows for efficient solvent recovery in industrial processes.

N-Methyl-2-pyrrolidone (NMP) is classified as a polar aprotic solvent, meaning it does not donate hydrogen ions but can solvate metal ions.
N-Methyl-2-pyrrolidone (NMP) is compatible with a variety of materials including plastics, rubbers, and metals.

It is considered a hazardous chemical and should be handled with appropriate safety precautions.
N-Methyl-2-pyrrolidone (NMP) has a relatively low vapor pressure, reducing the risk of inhalation exposure.

The viscosity of NMP can vary depending on temperature and concentration.
N-Methyl-2-pyrrolidone (NMP) is a versatile chemical with applications in diverse industries including pharmaceuticals, textiles, and coatings.

NMP is subject to regulatory controls due to its potential health and environmental impacts.
Overall, N-Methyl-2-pyrrolidone (NMP) is a valuable solvent and chemical intermediate with a wide range of industrial applications.

PROPERTIES

Chemical Formula: C5H9NO
Molecular Weight: Approximately 99.13 grams per mole
Physical State: Liquid
Color: Colorless to slightly yellow
Odor: Faint amine-like odor
Taste: Not applicable
Solubility in Water: Miscible
Solubility in Organic Solvents: Miscible with most organic solvents
Melting Point: Approximately -24°C
Boiling Point: Approximately 202°C
Density: Approximately 1.028 g/cm³ at 20°C
pH: Neutral
Viscosity: Relatively high viscosity
Refractive Index: Approximately 1.467 at 20°C
Flash Point: Approximately 95°C (closed cup)
Autoignition Temperature: Approximately 245°C
Vapor Pressure: Approximately 0.1 mmHg at 20°C
Heat of Combustion: Approximately -3289 kJ/mol
Heat of Vaporization: Approximately 47.9 kJ/mol
Specific Heat Capacity: Approximately 2.01 J/g°C
Surface Tension: Approximately 37.2 mN/m at 20°C
Dielectric Constant: Approximately 32.4 at 20°C
Hygroscopicity: Moderate
Flammability: Non-flammable under normal conditions
Toxicity: Considered toxic if ingested, inhaled, or absorbed through the skin

FIRST AID

Inhalation:

If inhaled, immediately remove the affected person to fresh air.
Assist the person to a well-ventilated area and ensure they are in a comfortable position.
If breathing is difficult, administer oxygen if trained to do so.
Seek medical attention promptly.
Keep the affected person under observation until medical help arrives.

Skin Contact:

Remove contaminated clothing and shoes immediately.
Wash the affected area with plenty of soap and water for at least 15 minutes.
Rinse skin thoroughly to remove any traces of NMP.
If irritation, redness, or rash develops, seek medical advice.
Apply a soothing moisturizer or barrier cream to the affected area to help alleviate discomfort.
Seek medical attention if symptoms persist or worsen.

Eye Contact:

Flush eyes with lukewarm water, keeping eyelids open, for at least 15 minutes.
Remove contact lenses if present and easily removable.
Seek immediate medical attention if irritation, pain, or redness persists.
Protect the unaffected eye to prevent contamination.
Provide relevant information about the chemical to medical personnel.

Ingestion:

Rinse mouth with water and drink plenty of water to dilute the substance.
Do not induce vomiting unless instructed to do so by medical personnel.
Seek medical attention immediately and provide information on the ingested substance.
Do not give anything by mouth to an unconscious person.

General Advice:

Keep affected person calm and reassure them.
If seeking medical attention, provide the Safety Data Sheet (SDS) or product label information to healthcare providers.
If the substance has entered the respiratory tract, monitor for signs of respiratory distress and administer CPR if necessary.
Do not administer any medications unless directed by medical personnel.
If exposed to large quantities or experiencing severe symptoms, seek emergency medical assistance immediately.
Be prepared to provide information on the specific product, concentration, and duration of exposure when seeking medical advice.
If transporting an affected individual to a medical facility, ensure proper ventilation and monitor their condition closely.

HANDLING AND STORAGE

Handling:

Personal Protective Equipment (PPE):
Wear suitable protective clothing, including gloves, safety glasses, and a lab coat, when handling NMP to prevent skin contact and eye irritation.
Use respiratory protection, such as a dust mask or respirator, if handling in powdered form or in poorly ventilated areas to prevent inhalation of dust particles.

Ventilation:
Handle NMP in a well-ventilated area or under a fume hood to minimize exposure to airborne particles and vapors.
Ensure adequate ventilation in storage areas to prevent the accumulation of vapors and maintain air quality.

Avoidance of Contamination:
Prevent contamination of NMP by keeping containers tightly closed when not in use.
Do not allow the substance to come into contact with incompatible materials, such as strong oxidizing agents or bases, to avoid hazardous reactions.

Safe Handling Practices:
Avoid generating dust or aerosols when handling NMP.
Use appropriate handling tools, such as scoops or spatulas, to minimize skin contact and prevent spills.
Do not eat, drink, or smoke while handling NMP to prevent accidental ingestion.

Emergency Procedures:
Familiarize yourself and other personnel with emergency procedures in case of spills, leaks, or exposure incidents.
Have appropriate spill control measures, absorbent materials, and personal protective equipment readily available.

Storage:

Storage Conditions:
Store NMP in a cool, dry, well-ventilated area away from sources of heat, moisture, and direct sunlight.
Keep containers tightly closed when not in use to prevent contamination and moisture absorption.

Temperature and Humidity:
Maintain storage temperature within the recommended range (typically room temperature) to ensure stability and minimize degradation.
Avoid exposure to extreme temperatures or fluctuations, as this may affect the quality and shelf life of the product.

Compatibility:
Store NMP away from incompatible materials, such as strong oxidizing agents, alkalis, and reducing agents, to prevent hazardous reactions.
Segregate NMP from other chemicals to avoid cross-contamination and potential hazards.

Labeling and Identification:
Clearly label storage containers with the product name, hazard warnings, handling instructions, and date of receipt.
Ensure proper identification and labeling of NMP to prevent confusion and facilitate safe handling and storage.

Security Measures:
Restrict access to storage areas containing NMP to authorized personnel only.
Implement appropriate security measures, such as locked cabinets or storage rooms, to prevent unauthorized access or tampering.

Spill Containment and Cleanup:
Have spill containment kits, absorbent materials, and personal protective equipment readily available for spill cleanup.
Follow established spill cleanup procedures and disposal guidelines to minimize environmental impact and ensure safety.

Regulatory Compliance:
Store and handle NMP in compliance with local regulations, codes, and guidelines governing the storage and handling of hazardous substances.
Maintain accurate records of storage conditions, inventory levels, and handling procedures for regulatory compliance and safety auditing purposes.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a versatile, polyfunctional molecule that combines thecharacteristics of amines and alcohols.
N-Methyldiethanolamine has a relatively low heat of reaction with hydrogen sulfide and carbon dioxide, which allows for lower reboiler duties, thus lower operating costs.

CAS Number: 105-59-9
EC number: 203-312-7
Molecular Formula: C5H13NO2
Molecular weight: 119.1622

N-Methyldiethanolamine is a dihydroxy functional tertiary amine.
N-Methyldiethanolamine is a versatile intermediate with a variety of applications.
N-Methyldiethanolamine's popularity as a solvent for gas treating stems from several advantages N-Methyldiethanolamine has when compared to other alkanolamines.

One of the advantages of N-Methyldiethanolamine is a low vapor pressure, which allows for high amine compositions without appreciable losses through the absorber and regenerator.
N-Methyldiethanolamine is also resistant to thermal and chemical degradation and is largely immiscible with hydrocarbons.
N-Methyldiethanolamine is a common base note in perfumes to allow the fragrance to last.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, ethanol and benzene.

N-Methyldiethanolamine has a relatively low heat of reaction with hydrogen sulfide and carbon dioxide, which allows for lower reboiler duties, thus lower operating costs.
N-Methyldiethanolamine's defining characteristic when compared to these other amines is N-Methyldiethanolamine's ability to preferentially remove H2S (and strip CO2) from sour gas streams.

N-Methyldiethanolamine is a colorless liquid.
N-Methyldiethanolamine is an alkanolamine.
N-Methyldiethanolamine is a commonly traded chemical that is subject to international controls, specifically under Schedule 3 of the Chemical Weapons Convention (CWC).

N-Methyldiethanolamine is a precursor to mechlorethamine (Bis(2-chloroethyl)methylamine), a nitrogen mustard chemical warfare agent developed for use as a vesicant or blister agent, similar to sulfur mustards.
The surface tension of N-Methyldiethanolamine in methanol, or in methanol aqueous solutions as a solvent, was measured at temperatures from 293.15 to 323.15 K.

On-site More selective for H2S over CO2 versus other amines, N-Methyldiethanolamine is commonly N-Methyldiethanolamine in amine units.
Miscible with water, low molecular weight alcohols, esters, acetone, benzene and chlorinated hydrocarbons; not miscible with diethylether or aliphatic hydrocarbons.
N-Methyldiethanolamine is a clear, colorless or pale yellow liquid with an ammonia odour.

N-Methyldiethanolamine is miscible with water, alcohol and benzene.
N-Methyldiethanolamine is also known as a MDEA or N-Methyl diethanolamine and has the formula CH3N (C2H4OH)2.

N-Methyldiethanolamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
N-Methyldiethanolamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

N-Methyldiethanolamine is a tertiary amine.
N-Methyldiethanolamine should not be confused with similarly named MEA or DEA and the commercial drug MDEA.

N-Methyldiethanolamine (MDEA) is a tertiary amine.
N-Methyldiethanolamine is a versatile, polyfunctional molecule that combines thecharacteristics of amines and alcohols.
N-Methyldiethanolamine is capable of undergoing reactions typical of both alcohols and amines, forming Quaternary amine salts, soaps, and esters.

N-Methyldiethanolamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Release to the environment of N-Methyldiethanolamine is likely to occur from outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

N-Methyldiethanolamine can be found in products with material based on plastic (e.g. food packaging and storage, toys, mobile phones).
N-Methyldiethanolamine is an amino alcohol, organic compound.

N-Methyldiethanolamine is obtained in industry through the interaction of ethylene oxide and methylamine.
Global N-Methyldiethanolamine demand exceeds 200,000 tonnes per year.

The rapid development in the production of liquefied natural gas determines the growth in the demand for N-Methyldiethanolamine based absorbents.
N-Methyldiethanolamine, also known as methyl diethanolamine, or MDEA, is an organic compound with the formula CH3N(C2H4OH)2.

N-Methyldiethanolamine is a colorless liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, alcohol, and benzene.

A combination of N-Methyldiethanolamine and piperazine is used.
The N-Methyldiethanolamine solution and the monoethanolamine solution are continuously regenerated through heat application.

A method for recycling liquid absorbent for acid vapor is comprising N-Methyldiethanolamine and lower alkylpiperazin.
N-Methyldiethanolamine (MDEA) is a colorless to yellow viscous liquid with an ammonia-like odor.

N-Methyldiethanolamine is completely soluble in water.
N-N-Methyldiethanolamine is an alkyl alkanolamine.
N-Methyldiethanolamine combines the chemical characteristics of both amines and alcohols so that N-Methyldiethanolamine is capable of undergoing reactions typical of both alcohols and amines: forming quaternary amine salts, soaps, and esters.

N-Methyldiethanolamine is produced by the reaction between ethylene oxide and methylamine.
N-Methyldiethanolamine is an aminoalcohol.

N-Methyldiethanolamine may react with oxidizing materials.
N-Methyldiethanolamine is readily biodegradable.

N-Methyldiethanolamine can react with halogenated organics, resulting in temperature and/or pressure increases.
N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH₃N(C₂H₄OH)₂.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine is miscible with water, alcohol, and benzene.
N-Methyldiethanolamine is an excellent solution for selectivity between H2S and CO2 removal.
N-Methyldiethanolamine can be used in higher concentrations up to 55wt%.

N-Methyldiethanolamine is a colorless, transparent liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, ethanol and benzene.

The addition of an activator, or more specifically piperazine (PZ) to an aqueous N-Methyldiethanolamine solution has found widespread application in the bulk removal of carbon dioxide.
N-Methyldiethanolamine is produced using methylamine and ethylene oxide ethoxylation.

N-Methyldiethanolamine reacts easily with hydrogen sulphide and carbon dioxide as a diluted solution, in order to eliminate hydrogen sulphide and carbon dioxide formed during the processing stage from natural gas and crude oil.
N-Methyldiethanolamine can be combined with water, benzene and alcohol.
N-Methyldiethanolamine is a clear, Colorless or Pale Yellow liquid with Ammonical Odor.

N-Methyldiethanolamine is miscible with water, alcohol and benzene.
N-Methyldiethanolamine is also known as a MDEA or N-Methyl Diethanolamine.

N-Methyldiethanolamine is more efficient absorber then MEA & DEA for sulphur contains impurity and acid gases found in natural gas processing.
N-Methyldiethanolamine is versatile bifunctional molecules compound that combines the characteristic of Amine and hydroxyl group.

During the reaction N-Methyldiethanolamine behaves like Alcohol and Amine Group but Amine group usually exhibits the greater activities.
N-Methyldiethanolamine can be modified with the help of some additives.
One of the most, popular and practical formulated amines is N-Methyldiethanolamine activated by piperazine (a-MDEA) which developed based on BASF company license in the early 1970s and the first commercial unit for sweetening of natural gases installed in 1982.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.
N-Methyldiethanolamine is miscible with water, ethanol and benzene.

N-Methyldiethanolamine's defining characteristic when compared to these other amines is N-Methyldiethanolamine's ability to preferentially remove H2S (and strip CO2) from sour gas streams.
N-Methyldiethanolamine's popularity as a solvent for gas treating stems from several advantages N-Methyldiethanolamine has when compared to other alkanolamines.

N-Methyldiethanolamine is also resistant to thermal and chemical degradation and is largely immiscible with hydrocarbons.
N-Methyldiethanolamine is first esterified with 2 molecules of fatty acid (mostly C12-acid or stearic acid).

N-Methyldiethanolamine is a clear hygroscopic liquid with an amine-like odor.
The freshly distilled N-Methyldiethanolamine is colorless, but prolonged storage may cause a yellowish discoloration.

N-Methyldiethanolamine (MDEA) a clear, water-white, hygroscopic liquid with an ammoniacal odor.
Bulk carbon dioxide removal can be realized with N-Methyldiethanolamine when the CO2:H2S ratio ranges from 100 to 1,000.

N-Methyldiethanolamine, or methyl diethanolamine, or MDEA, is organic synthesis.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine is miscible with water, alcohol, and benzene.
N-Methyldiethanolamine is utilized for amine gas treating, for gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical manufacturing and production.
N-Methyldiethanolamine molecule consists of 13 Hydrogen atom(s), 5 Carbon atom(s), 1 Nitrogen atom(s) and 2 Oxygen atom(s) - a total of 21 atom(s).

N-Methyldiethanolamine, also known as methyl diethanolamine, or MDEA, is an organic compound with the formula CH3N(C2H4OH)2.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine is miscible with water, alcohol, and benzene.
N-Methyldiethanolamine is a colorless liquid with an ammonia odor.

N-Methyldiethanolamine, also known as N-methyl diethanolamine and more commonly as MDEA, is the organic compound with the formula CH 3N(C 2H 4OH) 2.
N-Methyldiethanolamine (MDEA) is a colorless liquid.
The pKa of N-Methyldiethanolamine is 8.52, indicating that N-Methyldiethanolamine will partially exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts.

N-Methyldiethanolamine is an organic compound and the formula of N-Methyldiethanolamine is CH3N (C2H4OH)2.
N-Methyldiethanolamine can be mixed with alcohol, water and benzene.

The advantages of N-Methyldiethanolamine as compared to other amines is N-Methyldiethanolamine had the ability to remove H2S and CO2 from the sour gas streams.
N-Methyldiethanolamine has several advantages as compared to other alkanolamines.

N-Methyldiethanolamine has a low heat of reaction with the carbon dioxide and hydrogen sulphide and which allows lower reboiler duties due to the lower operating costs.
Purest N-Methyldiethanolamine can used to remove the H2S and CO2 during the gas treating process.
The N-Methyldiethanolamine is commonly used in refineries, petrochemical plants, natural gas processing plants and other industries.

Uses of N-Methyldiethanolamine:
N-Methyldiethanolamine is used as an intermediate, to absorb acidic gases, as catalyst for polyurethane foams, and pH control agent.
N-Methyldiethanolamine is used in chemical syntheses (i.e. pharmaceuticals and cationic surfactants), as a cleaning-washing agent, pH regulator (coating manufacture), and solvent (removal of acid gases in oil refineries).
N-Methyldiethanolamine is used to make fine and large scale chemicals, as a catalyst in polymerization reactions, laboratory reagent, additive in coatings and concrete-cement, in gas treatment, and lubricants and metalworking fluids.

Consumer Uses:
N-Methyldiethanolamine is used in the following products: washing & cleaning products.
Other release to the environment of N-Methyldiethanolamine is likely to occur from: indoor use as processing aid.

Other Consumer Uses:
Not Known or Reasonably Ascertainable
Paint additives and coating additives not described by other categories
Processing aids, specific to petroleum production

Widespread uses by professional workers:
N-Methyldiethanolamine is used in the following products: coating products, lubricants and greases, metal working fluids, polymers, laboratory chemicals, pH regulators and water treatment products and washing & cleaning products.
N-Methyldiethanolamine is used in the following areas: building & construction work and scientific research and development.

N-Methyldiethanolamine is used for the manufacture of: and plastic products.
Other release to the environment of N-Methyldiethanolamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industrial sites:
N-Methyldiethanolamine is used in the following products: laboratory chemicals, coating products, pH regulators and water treatment products, lubricants and greases, metal working fluids and polymers.
N-Methyldiethanolamine is used in the following areas: building & construction work and scientific research and development.

N-Methyldiethanolamine is used for the manufacture of: chemicals, and plastic products.
Release to the environment of N-Methyldiethanolamine can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release, in the production of articles and as processing aid.

Industry Uses:
Absorbent
Intermediate
Intermediates
Not Known or Reasonably Ascertainable
Paint additives and coating additives not described by other categories
Processing aids not otherwise specified
Processing aids, specific to petroleum production
Solvent
pH regulating agent

Industrial Processes with risk of exposure:
Metal Machining
Petroleum Production and Refining
Painting (Pigments, Binders, and Biocides)
Cement Producing

Applications of N-Methyldiethanolamine:
N-Methyldiethanolamine is used as a co-initiator for type II photoinitiator combinations.
As a neutralizing agent, N-Methyldiethanolamine increases resin solubility and improves solution stability by reducing pH drift.
N-Methyldiethanolamine aids pigment dispersion.

N-Methyldiethanolamine can be used as a chain extender during the synthesis of polyol-based polyurethane foams and elastomers.
N-Methyldiethanolamine is used as a co-initiator for type II photoinitiator combinations.

In metal working fluids, N-Methyldiethanolamine is used both as a pH buffer as well as an anticorrosion additive.
N-Methyldiethanolamine forms quat salts with fatty acids which then find application in fabric softener formulations.

Preventing the formation of bicine in operating N-Methyldiethanolamine solvents is accepted as the best way to control corrosion.
A tertiary amine, N-Methyldiethanolamine is widely used as a sweetening agent in chemical, oil refinery, syngas production and natural gas.

The BASF-formulated N-Methyldiethanolamine solvent achieves a high degree of COS removal and retains appreciable selectivity for H2S over CO2.
N-Methyldiethanolamine is a useful intermediate in the synthesis of numerous products, and has resulted in N-Methyldiethanolamine use in many diverse areas, including coatings, textile lubricants, polishes, detergents,pesticides, personal care products, and pharmaceuticals.

N-Methyldiethanolamine is an alkyl alkanolamine that is used in gas treatment applications and serves as an intermediate in the synthesis of numerous products.
N-Methyldiethanolamine is widely used as a sweating agent or decarbonizer in chemical, oil refinery, syngas production and natural gas.

Monitoring N-Methyldiethanolamine levels in rich and lean amine can help maintain appropriate corrosion protection, extending system lifetime and avoiding costly corrosion-induced shutdowns and failures.
N-Methyldiethanolamine is used as an intermediate, to absorb acidic gases, as catalyst for polyurethane foams, and pH control agent.
N-Methyldiethanolamine is used in chemical syntheses (i.e. pharmaceuticals and cationic surfactants), as a cleaning-washing agent, pH regulator (coating manufacture), and solvent (removal of acid gases in oil refineries).

N-Methyldiethanolamine is used to make fine and large scale chemicals, as a catalyst in polymerization reactions, laboratory reagent, additive in coatings and concrete-cement, in gas treatment, and lubricants and metalworking fluids.
Permitted for use as an inert ingredient in non-food pesticide products.
N-Methyldiethanolamine (MDEA) is a widely-used corrosion inhibitor that acts as a hydrogen sulfide scavenger in oil and gas processing.

N-Methyldiethanolamine has also been used as a chemotherapy agent in the treatment of Hodgkin lymphoma, leukaemia, and lung cancer.
N-Methyldiethanolamine is a reagent used for protection of boronic acids as N-methyl-O,O-diethanolamine esters.
N-Methyldiethanolamine is known by at least 93 different synonyms and has many commercial applications, including in the manufacture of construction and building materials, ink for inkjet printers, film forming, and as a component in fragrances.

Synthesis of aluminophosphate-based molecular sieves.
Preparation of N-methyl-N-R-N,N-bis(2-hydroxyethyl) ammonium bromides.

Preparation of cationic polyurethane dispersions.
N-Methyldiethanolamine is used in Urethanes, Paper Chemicals, Textile Softners, Pharmaceuticals, Gas scrubbing (CO2, H2S removal in natural, refining gas, ammonia hydrogen unit), Dyes and Polyurethane.

N-Methyldiethanolamine is used in the following products: coating products, lubricants and greases, metal working fluids, polymers and laboratory chemicals.
N-Methyldiethanolamine is used in the building & construction work.
N-Methyldiethanolamine is used for the manufacture of plastic products.

N-Methyldiethanolamine is used in the polymers.
N-Methyldiethanolamine is used in the laboratory chemicals, pH regulators and water treatment products, coating products, lubricants and greases, metal working fluids and polymers.

N-Methyldiethanolamine has an industrial use resulting in manufacture of another substance (use of intermediates).
N-Methyldiethanolamine is used for the manufacture of chemicals and textile, leather or fur.

N-Methyldiethanolamine is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
N-Methyldiethanolamine, as well as special sorbents based on N-Methyldiethanolamine (various grades of special modified MDEA), are widely used in amine treatment for the removal of acidic impurities from natural and process gases.
N-Methyldiethanolamine is used in the chemical industry and the production of synthetic detergents.

As a tertiary amine, N-Methyldiethanolamine is widely used as a sweetening agent in chemical plants, oil refineries, syngas, and natural gas production.
N-Methyldiethanolamine is used as an intermediate in the synthesis of numerous products.
N-Methyldiethanolamine's unique chemistry has resulted in N-Methyldiethanolamine use in diverse areas, including coatings, textile lubricants, polishes, detergents, pesticides, personal-care products, pharmaceuticals, urethane catalysts, and water-treatment chemicals.

N-Methyldiethanolamine is also used in absorption of acidic gases, catalyst for polyurethane foams, pH control agent.
N-Methyldiethanolamine is a reagent used for protection of boronic acids as N-methyl-O,O-diethanolamine esters.
N-Methyldiethanolamine is used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical industry.

N-Methyldiethanolamine is a tertiary amine and is widely used as a sweetening agent in chemical, oil refinery, syngas production and natural gas.
N-Methyldiethanolamine is used mainly in the construction industry.
N-Methyldiethanolamine is also used as an intermediate for agricultural chemicals, emulsifiers, textile auxiliaries, corrosion inhibitors, dyes, coatings, pharmaceuticals and also as a catalyst for polyurethane foam production.

N-Methyldiethanolamine is commonly used for the treatment of amine gas and for gas sweetening.
In the petrochemical industry, N-Methyldiethanolamine is generally used to treat amine gas, also known as gas sweeter or acid gas removal, to remove hydrogen sulphide and carbon dioxide from fuels.

N-Methyldiethanolamine is a common base note in perfumes to allow the fragrance to last.
N-Methyldiethanolamine is widely used as a sweetening agent in chemical, oil refinery, syngas production and natural gas.

N-Methyldiethanolamine is used in manufacturing of softener, soap emulsifying agent, Lubricants, Paraffin Emulsion and dyes.
In synthesis of analgesics and the intermediate product for some products.

Purifies the gases particularly natural gas for the bulk removable of Carbon Dioxide and also used as a scrubbing and extracting agent in Gas treatment.
Effective catalyst for urethane and epoxy resin coating system.

N-Methyldiethanolamine is used in lubricating oil, hydraulic fluids, corrosion inhibitor, refractory binder, surface active agent, solvent in water paint formula, Herbicides, Pesticides formulation and for PH control.
N-Methyldiethanolamine is widely used as a decarbonizer and Sweating agent in chemical, oil refinery, Gas synthesis, Natural gas & gas.

The use of tertiary N-Methyldiethanolamine (MDEA) as an absorbent for the CO2 removal from process gas streams has increased due to N-Methyldiethanolamine advantages over primary and secondary amines.
The various types of amines such as N-Methyldiethanolamine (MDEA) have been used for gas treating systems in a wide variety of applications.

The amino-alcohol functionality of N-Methyldiethanolamine makes N-Methyldiethanolamine a very useful precursor for fatty ester quaternaries (also called esterquats).
N-Methyldiethanolamine are commonly used as active substances in fabric softeners and are a good alternative to the TEA-esterquats (based on triethanolamine), in terms of both biodegradability and cost/performance.

N-Methyldiethanolamine can be used in the cationic modification of acrylic polymer dispersions.
In the production of silicone-based textile finishing agents, N-Methyldiethanolamine is used in combination with perfluoroalkyl polymers.
By reaction with epichlorohydrin and formic acid hydroxy functionalized quaternary ammonium compounds based on N-Methyldiethanolamine can be transformed into cationic polyurethanes, useful as paper sizing agents.

N-Methyldiethanolamine can be used as a precursor for pharmaceutical active substances.
N-Methyldiethanolamine is an alkanolamine used in tail gas treating and hydrogen sulfide enrichment units for selectively removing hydrogen sulfide from gas streams containing carbon dioxide.
N-Methyldiethanolamine is also used in natural gas plants for the bulk removal of carbon dioxide while producing a gas stream containing 0.25 grains hydrogen sulfide/100 scf.

Uses are urethane catalyst, textile softeners, pH control, and epoxy resin curing agents.
N-Methyldiethanolamine (N-methyl-diethanolamine), CH3N (C2H4OH)2, a chemical used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulphide and carbon dioxide from gases in the petrochemical industry.
N-Methyldiethanolamine (MDEA) is a tertiary amine commonly used to remove acid gases from gas streams.

N-Methyldiethanolamine (105-59-9) is a reagent used to protect boric acid as N-methyl-O,O-diethanolamine ester.
N-Methyldiethanolamine is used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical industry.
N-Methyldiethanolamine (MDEA) is a tertiary amine and commonly used for removal of acid gases from gas streams.

N-Methyldiethanolamine is used as an intermediate, in absorption of acidic gases, as a catalyst for polyurethane foams, and pH control agent.
N-Methyldiethanolamine tertiary amine most commonly used for sweetening syngas production, oil refinary, chemical, and natural gas.

Similarly like the compounds of N-Methyldiethanolamine the primary amine monoethanolamine (MEA) and the secondary amine diethanolamine (DEA) both can be used for amine gas treating.
N-Methyldiethanolamine also used to resistant the chemical and thermal degradation.
N-Methyldiethanolamine amine gas treating process most commonly used for petrochemical plants, refineries, natural gas processing plants and food & beverage industry.

One of the major application of N-Methyldiethanolamine is gas treating.
N-Methyldiethanolamine is mainly used as an active substance in fabric softeners and is a good alternative to TEA.
In the paints industry N-Methyldiethanolamine is utilized in combination with perfluoroalkyl acid polymers to produce silicone-based textile finishing agents.

Advantages of N-Methyldiethanolamine:
Selectivity to hydrogen sulphide.
Reduction of 30% in energy consumption.
Increased productivity.
Low corrosiveness.
No resin formation.
Reduction in circulating absorbent consumption.

Blends of N-Methyldiethanolamine:
N-Methyldiethanolamine is less reactive towards CO2, but has an equilibrium loading capacity approaching 1 mole CO2 per mole amine.
N-Methyldiethanolamine also requires less energy to regenerate.
To combine the advantages of N-Methyldiethanolamine and the smaller amines, N-Methyldiethanolamine is usually mixed with a catalytic promoter such as piperazine, PZ, or a fast reacting amine such as MEA to retain reactivity, but lower regeneration costs.

Activated N-Methyldiethanolamine or aMDEA uses piperazine as a catalyst to increase the speed of the reaction with CO2.
N-Methyldiethanolamine has been commercially successful.
Many tests have been done on the performance of N-Methyldiethanolamine/MEA or N-Methyldiethanolamine/piperazine mixtures compared to single amines.

CO2 production rates were higher than MEA for the same heat duty and total molar concentration when experiments were performed in the University of Regina pilot plant, which is a modeled after a natural gas plant.
There were also insignificant trace amounts of degradation products detected.
When the same control variables and tests were conducted at the Boundary Dam Power Station plant, the CO2 production rate for the mixed solvent was lower than MEA.

This was a result of the reduction in the capacity of the solvent to absorb CO2 after degradation.
Because the Boundary Dam plant is a coal-fired power plant, N-Methyldiethanolamine operates under harsher environments and produces an impure flue gas containing, fly ash, SO2, and NO2 that are fed into carbon capture.

Even with flue gas pretreatment, there is still enough to produce degradation products such as straight chain amines and sulfur compounds, which accumulate so N-Methyldiethanolamine is no longer possible to regenerate MEA and N-Methyldiethanolamine.
For these blends to be successful in reducing heat duty, their chemical stabilities must be maintained.

Degradation of N-Methyldiethanolamine:
Main oxidative degradation products of N-Methyldiethanolamine include monoethanol amine (MEA), methyl-aminoethanol (MAE), diethanolamine (DEA), amino acids bicine, glycine and hydroxyethyl sarcosine (HES), formyl amides of MAE and DEA, ammonia, and stable salts formate, glycolate, acetate, and oxalate.

In an industrial plan that utilizes N-Methyldiethanolamine, oxidative degradation is most likely to shift to the cross exchanger where temperatures are greater than 70 °C.
Higher temperatures and higher CO2 loading accelerate the rate of degradation, resulting in an increase of alkalinity loss as well as total formate production.

While N-Methyldiethanolamine is more resistant to degradation as a standalone compared to MEA, N-Methyldiethanolamine is preferentially degraded when in an N-Methyldiethanolamine/MEA blend.
Because of the formation of DEA and MAE, which could form nitroso-compounds or diethylnitrosamine and diethylnitraine, the blend could potentially have an adverse impact in terms of atmospheric admissions.

In the Boundary Dam plant, emissions increased when CO2 loading of lean amine increased for the blend and MEA.
Decreasing the lean loading increases the reboiler heat duty, which results in an obvious tradeoff between emissions and heat duty or energy costs.

Production of N-Methyldiethanolamine:
N-Methyldiethanolamine is produced by ethoxylation of methylamine using ethylene oxide:
CH3NH2 + 2 C2H4O → CH3N(C2H4OH)2
Another route involves hydroxymethylation of diethanolamine followed by hydrogenolysis.

N-Methyldiethanolamine production consists of the following stages:
N-Methyldiethanolamine synthesis.

Methylamine distillation and recycling.
Methylmonoethanolamine distillation and recycling.

Separation of commercial N-Methyldiethanolamine.
Synthesis is carried out in the liquid phase from ethylene oxide and methylamine in anhydrous medium, at a temperature of 60-90 °С and pressure up to 1 MPa.
The process is autocatalytic.
The technology is characterised by high quality commercial N-Methyldiethanolamine and low energy consumption.

General Manufacturing Information of N-Methyldiethanolamine:

Industry Processing Sectors:
Adhesive Manufacturing
All Other Basic Organic Chemical Manufacturing
Oil and Gas Drilling, Extraction, and Support activities
Paint and Coating Manufacturing
Petroleum Refineries
Printing Ink Manufacturing
Wholesale and Retail Trade

Handling and Storage of N-Methyldiethanolamine:

Protective measures:

Fire preventions:
No smoking.

Advice on general occupational hygiene:
Not to eat, drink and smoke in work areas.
Wash hands after use

Conditions for safe storage, including any incompatibilities:
Containers should be stored tightly sealed in a dry place.

Storage duration: 12 Months.

Stability and Reactivity of N-Methyldiethanolamine:

Reactivity:
No hazardous reactions if stored and handled as prescribed/indicated.

Chemical stability:
N-Methyldiethanolamine is stable when rules of storage and use are observed.

First Aid Measures of N-Methyldiethanolamine:

General informations:
Remove contaminated clothing.

Following inhaled:
Keep patient calm, remove to fresh air.
Seek medical attention.

Following skin contact:
Wash thoroughly with soap and water.

Following eye contact:
Wash affected eye.

Following ingestion:
Immediately rinse mouth.
Seek medical attention.

Indication of any immediate medical attention and special treatment needed Treatment:
No known specific antidote.

Accidental Release Measures of N-Methyldiethanolamine:

Personal precautions, protective equipment and emergency procedures:

Environmental precautions:
Do not discharge into drains/surface waters/groundwater.

Methods for cleaning up or taking up:

For large amounts:
Pump off product.

For residues:
Pick up with suitable absorbent material (e.g. sand, sawdust, general-purpose binder, kieselguhr).
Dispose of absorbed material in accordance with regulations.

Fire Fighting Measures of N-Methyldiethanolamine:

Extinguishing media:

Suitable extinguishing media:
Water spray, dry powder, alcohol-resistant foam, carbon dioxide.

Additional information:
Do not allow to reach sewage or effluent systems.

Exposure Controls/personal Protection:
Control parameters

Ingredients with workplace control parameters:

Exposure controls:

Appropriate engineering controls:
Change contaminated clothing.
Wash hands after working with substance.

Personal protective equipment:

Eye/face protection:
Safety glasses

Skin protection:

Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min

Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 60 min

Body Protection:
Use protective clothing

Control of environmental exposure:
Do not let product enter drains.

Spillage Disposal of N-Methyldiethanolamine:

Personal protection:
Filter respirator for organic gases and vapours adapted to the airborne concentration of N-Methyldiethanolamine.
Do NOT let this chemical enter the environment.

Collect leaking and spilled liquid in covered containers as far as possible.
Absorb remaining liquid in sand or inert absorbent.
Then store and dispose of according to local regulations.

Cleanup Methods of N-Methyldiethanolamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Disposal Methods of N-Methyldiethanolamine:
Recycle any unused portion of N-Methyldiethanolamine for N-Methyldiethanolamine approved use or return N-Methyldiethanolamine to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
N-Methyldiethanolamine's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations.
If N-Methyldiethanolamine is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Preventive Measures of N-Methyldiethanolamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Environmental precautions:
Do not let product enter drains.

Identifiers of N-Methyldiethanolamine:
CAS Number: 105-59-9
Beilstein Reference: 1734441
ChEMBL: ChEMBL3185149
ChemSpider: 7479
ECHA InfoCard: 100.003.012
EC Number: 203-312-7
MeSH: N-methyldiethanolamine
PubChem CID: 7767
RTECS number: KL7525000
UNII: 3IG3K131QJ
CompTox Dashboard (EPA): DTXSID8025591
InChI: InChI=1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
Key: CRVGTESFCCXCTH-UHFFFAOYSA-N
SMILES: CN(CCO)CCO

Synonym(s): 2,2′-Methyliminodiethanol, N,N-Bis(2-hydroxyethyl)methylamine, MDEA
Linear Formula: CH3N(CH2CH2OH)2
CAS Number: 105-59-9
Molecular Weight: 119.16
Beilstein: 1734441
EC Number: 203-312-7
MDL number: MFCD00002848
PubChem Substance ID: 24870762
NACRES: NA.22

Properties of N-Methyldiethanolamine:
Molecular weight: 119.1622
Appearance: Colorless liquid
Odor: Ammoniacal
Density: 1.038 g mL−1
Melting point: −21.00 °C; −5.80 °F; 252.15 K
Boiling point: 247.1 °C; 476.7 °F; 520.2 K
Solubility in water: Miscible
Vapor pressure: 1 Pa (at 20 °C)
Refractive index (nD): 1.4694
Viscosity: 101 mPa s (at 20°C)

Chemical formula: C5H13NO2
Molar mass: 119.164 g·mol−1
Appearance: Colorless liquid
Odor: Ammoniacal
Density: 1.038 g mL−1
Melting point: −21.00 °C; −5.80 °F; 252.15 K
Boiling point: 247.1 °C; 476.7 °F; 520.2 K
Solubility in water: Miscible
Vapor pressure: 1 Pa (at 20 °C)
Refractive index (nD): 1.4694
Viscosity: 101 mPa s (at 20°C)

vapor density: 4 (vs air)
Quality Level: 200
vapor pressure: 0.01 mmHg ( 20 °C)
Assay: ≥99%
autoignition temp.: 770 °F

expl. lim.:
99 %, 55 °F
~56 %, 23 °F
~8.8 %

refractive index: n20/D 1.469 (lit.)
bp: 246-248 °C (lit.)
density: 1.038 g/mL at 25 °C (lit.)
SMILES string: CN(CCO)CCO
InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
InChI key: CRVGTESFCCXCTH-UHFFFAOYSA-N

XLogP3-AA: -1.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 119.094628657
Monoisotopic Mass: 119.094628657
Topological Polar Surface Area: 43.7 Å²
Heavy Atom Count: 8
Complexity: 43.7
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Related compounds of N-Methyldiethanolamine:
Diethylhydroxylamine

Related alkanols:
N-Methylethanolamine
Dimethylethanolamine
Diethylethanolamine
Diethanolamine
N,N-Diisopropylaminoethanol
Triethanolamine
Bis-tris methane

Names of N-Methyldiethanolamine:

Regulatory process names:
2,2'-(Methylimino)diethanol
2,2'-(methylimino)diethanol; N-methyldiethanolamine
2,2'-methyliminodiethanol
2,2'-methyliminodiethanol
2-(N-2-Hydroxyethyl-N-methylamino)ethanol
Bis(2-hydroxyethyl) methyl amine
Ethanol, 2,2'-(methylimino)bis-
Ethanol, 2,2'-(methylimino)di-
MDEA
Methylbis(2-hydroxyethyl)amine
N,N-Bis(2-hydroxyethyl)methylamine
N,N-Di(2-hydroxyethyl)-N-methylamine
N-Methyl-2,2'-iminodiethanol
N-Methylaminodiglycol
N-Methyldiethanolamine
N-Methyldiethanolimine
N-Methyliminodiethanol

Translated names:
2,2'-(metilimino)dietanolis N-metildietanolaminas (lt)
2,2'-metiliminodietanol N-metildietanolamin (sl)
2,2'-μεθυλιμινοδιαιθανόλη N-μεθυλοδιαιθανολαμίν (el)
2,2’-(metilimino)dietanol N-metildietanolamin (hu)

IUPAC names:
2,2'-(Methylazanediyl)di(ethan-1-ol)
2,2'-(methylimino)diethanol
2,2'-(methylimino)diethanol
2,2'-Methyliminodiethanol
2,2'-methyliminodiethanol
2,2'-Methyliminodiethanol
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
2-[2-hydroxyethyl(methyl)amino]ethanol
Bis(2-hydroxyethyl)methylamine
MDEA
Methyldiethanolamine
Methyldiethanolamine
N,N(Bis-2 Hydroxy ethyl) Methylamine
N-Methyldiethanolamine
N-methyldiethanolamine

Preferred IUPAC name:
2,2′-(Methylazanediyl)di(ethan-1-ol)

Trade names:
2,2'-(Methylimino)diethanol
Amietol M12
Bis(2-hydroxyethyl) methyl amine
Diethanolmethylamine
Ethanol, 2,2'-(methylimino)bis- (9CI)
Ethanol, 2,2'-(methylimino)di- (6CI, 8CI)
Eve
MDEA
Methylbis(2-hydroxyethyl)amine
Methyldiethanolamin
Methyldiethanolamine
Methyliminodiethanol
N,N-Bis(2-hydroxyethyl)methylamine
N-Methylaminodiglycol
N-Methyldiethanolamine
N-METHYLDIETHANOLAMINE (MDEA)
N-Methyliminodiethanol

Other names:
Bis(2-hydroxyethyl)(methyl)amine

Other identifiers:
105-59-9
511262-76-3
603-079-00-5
944314-72-1

Synonyms of N-Methyldiethanolamine:
N-METHYLDIETHANOLAMINE
105-59-9
Methyldiethanolamine
Bis(hydroxyethyl)methylamine
2,2'-(Methylimino)diethanol
Methyl diethanolamine
Ethanol, 2,2'-(methylimino)bis-
N-Methylaminodiglycol
N-Methyliminodiethanol
591248-66-7
N-Methyl-2,2'-iminodiethanol
2,2'-Methyliminodiethanol
N-Methyldiethanolimine
2-[2-hydroxyethyl(methyl)amino]ethanol
USAF DO-52
N,N-Bis(2-hydroxyethyl)methylamine
Bis(2-hydroxyethyl)methylamine
Methylbis(2-hydroxyethyl)amine
Diethanolmethylamine
Methyliminodiethanol
Ethanol, 2,2'-(methylimino)di-
N-methyl diethanolamine
N,N-Di(2-hydroxyethyl)-N-methylamine
Bis(2-hydroxyethyl) methyl amine
NSC 11690
CCRIS 4843
2-(N-2-Hydroxyethyl-N-methylamino)ethanol
EINECS 203-312-7
BRN 1734441
UNII-3IG3K131QJ
3IG3K131QJ
N-Methylimino-2,2'-diethanol
DTXSID8025591
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
HSDB 6804
NSC-11690
EC 203-312-7
4-04-00-01517 (Beilstein Handbook Reference)
Ethanol,2'-(methylimino)di-
Ethanol,2'-(methylimino)bis-
WLN: Q2N1 & 2Q
N-methyl-diethanolamine
Mdea (diol)
N-Methyldethanolamne
methyl diethanol amine
MDE (CHRIS Code)
n-methyl-diethanol amine
N-methyl diethanol-amine
AMINO ALCOHOL MDA
di(hydroxyethyl)methylamine
SCHEMBL17605
bis-(Hydroxyethyl)methylamine
N-Methyl-2,2-iminodiethanol
N-Methyldiethanolamine, 99%
DTXCID605591
METHYLDIETHANOLAMINE, N-
CHEMBL3185149
N-Methyldiethanolamine, >=99%
2,2'-(methylazanediyl)diethanol
Etanol, 2,2'-(metilimino) bis-
NSC11690
NSC49131
NSC51500
METHYL DIETHANOLAMINE [INCI]
Tox21_201199
LS-389
MFCD00002848
N-METHYLDIETHANOLAMINE [HSDB]
NSC-49131
NSC-51500
STL281951
N-(2-Hydroxyethyl)-N-methylethanolam
AKOS009031354
N,N-bis-(2-hydroxyethyl)-methylamine
n-methyl-n,n-bis(2-hydroxyethyl)amine
AT34020
2,2'-(METHYLIMINO)BIS(ETHANOL)
NCGC00248955-01
NCGC00258751-01
CAS-105-59-9
2-[(2-hydroxy-ethyl)methyl-amino]-ethanol
FT-0663293
M0505
2,2'-(METHYLAZANEDIYL)BIS(ETHAN-1-OL)
2-Hydroxy-1-[(2-hydroxyethyl)methylamino]-ethyl
Q252344
J-523676
N-Methyldiethanolamine 1000 microg/mL in Ammonium Hydroxide
InChI=1/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H
2,2'-(Methylimino)diethanol
2,2′-Methyliminodiethanol
2,2'-Methyliminodiethanol
203-312-7 [EINECS]
Ethanol, 2,2'- (methylimino)bis-
Ethanol, 2,2'-(methylimino)bis-
MDEA
Methyl diethanolamine
N,N-Bis(2-hydroxyethyl)methylamine
N-Methyldiethanolamine
2-(2-hydroxyethyl-methylamino)ethanol
2-(2-hydroxyethyl-methyl-amino)ethanol
2-(N-2-Hydroxyethyl-N-methylamino)ethanol
2,2'-(Methylimino)bisethanol
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
2-[2-hydroxyethyl(methyl)amino]ethanol
203245-16-3 [RN]
2-Hydroxy-1-[(2-hydroxyethyl)methylamino]-ethyl
4-04-00-01517 [Beilstein]
Bis(2-hydroxyethyl) methyl amine
Bis(2-hydroxyethyl)methylamine
bis(2-hydroxyethyl)-methylammonium
bis-(Hydroxyethyl)methylamine
Bis(hydroxyethyl)methylamine
Diethanolmethylamine
Ethanol, 2,2'- (methylimino)di-
Ethanol, 2,2'-(methylimino)di-
ethanol, 2,2prime-methyliminodi-
Methylbis(2-hydroxyethyl)amine
METHYLDIETHANOLAMINE
METHYL-DIETHANOLAMINE
Methyldiethanolamine Reagent Grade
Methyliminodiethanol
Methyllimino, Methylamine, MDEA
N-(2-Hydroxyethyl)-N-methylethanolam
N,N-Di(2-hydroxyethyl)-N-methylamine
N-methyl diethanolamine
N-methyl-2,2′-iminodiethanol
N-Methyl-2,2'-iminodiethanol
N-Methyl-2,2-iminodiethanol
N-Methylaminodiglycol
N-Methyl-diethanol amine
N-Methyldiethanolamine (en)
N-Methyldiethanolamine 1000 Ã‚Âµg/mL in Ammonium Hydroxide
N-Methyldiethanolamine, 1000 mg/L, 1 ml
N-Methyldiethanolamine, N-Methyl-2,2-iminobis(ethanol)
N-Methyldiethanolimine
N-Methylimino-2,2'-diethanol
N-METHYLIMINODIETHANOL

SYNONYMS 2,2'-Methyliminodiethanol; N-methyliminodiethanol;N-methyl-2,2'-iminodiethanol; MDEA; N,N-Bis(2-hydroxyethyl)methylamine; CAS NO:105-59-9

N-METHYLMORPHOLINE = 4-METHYLMORPHOLINE = NMM

CAS Number: 109-02-4
EC Number: 203-640-0
MDL number: MFCD00006175
Chemical formula: C5H11NO

N-Methylmorpholine is colorless transparent liquid.
N-Methylmorpholine has a special odor.
The relative density of N-Methylmorpholine is 0.919.
N-Methylmorpholine's Viscosity is 0.90mPa.s(20 degrees C), vapor pressure (20 °c) 2.213kPa, and soluble in organic solvents, miscible with water and ethanol.

N-Methylmorpholine is the organic compound with the formula O(CH2CH2)2NCH3.
N-Methylmorpholine is a colorless liquid.
N-Methylmorpholine is a cyclic tertiary amine.
N-Methylmorpholine appears as a water-white liquid with an ammonia-like odor.

N-Methylmorpholine is less dense than water and insoluble in water.
N-Methylmorpholine may be moderately toxic by ingestion, inhalation and skin absorption.
N-Methylmorpholine is a natural product found in Senna occidentalis with data available.
N-Methylmorpholine is liquid with pungent odor, colorless transparent liquid.

N-Methylmorpholine's viscosity (23 ℃) is 2.3mPa · s.
N-Methylmorpholine's boiling range is 111~117 ℃.
N-Methylmorpholine's freezing point is -65 ~-66 ℃, refractive index (20 ℃) 1.4328~1.4337, and vapor pressure (20 ℃) 2200Pa.
N-Methylmorpholine's solubility in water is pKa = 7.5, and explosion limit of 2.2% ~ 11.8% in air, soluble in organic solvents, miscible with water and ethanol

N-Methylmorpholine is a morpholine-containing compound used for protein sequencing analysis.
N-Methylmorpholine is colorless and transparent liquid. with characteristic odor.
N-Methylmorpholine is soluble in organic solvents, miscible with water and ethanol.

N-Methylmorpholine is a water-white liquid with an ammonia-like odor.
N-Methylmorpholine is less dense than water and insoluble in water.
N-Methylmorpholine is insoluble in water.

USES and APPLICATIONS of N-METHYLMORPHOLINE:
N-Methylmorpholine is used as solvent for peptide and protein synthesis and sequencing.
N-Methylmorpholine is also a starting material for preparing N-methylmorpholine N-oxide.
N-Methylmorpholine is mainly used as a solvent, Catalyst, corrosion inhibitor.
N-Methylmorpholine is also used for rubber vulcanization accelerator and other fine chemicals synthesis.

N-Methylmorpholine is also used as polyurethane plastic foaming catalyst, catalysts for the synthesis of aminobenzylpenicillin and carboxy benzylpenicillin.
N-Methylmorpholine can be produced by oxidation with hydrogen peroxide N-methyl morpholine oxide.
Recently, with N-methyl morpholine oxide as solvent, a "new technology for preparing synthetic fiber by solvent" has been developed abroad, which will open up broad prospects for the application of N-methyl Morpholine.

N-Methylmorpholine is used intermediates in Pharmaceuticals, Intermediate for chemical synthesis.
N-Methylmorpholine is soluble in water, alcohol, ether, can be used as a solvent for rayon, corrosion inhibitors, but also for the synthesis of rubber accelerators and other fine chemicals, also used as a polyurethane catalyst, catalysts for the synthesis of aminobenzylpenicillin and hydroxypenicillin.

N-Methylmorpholine oxide can be produced by double oxidation.
N-Methylmorpholine is used as a base catalyst for generation of polyurethanes and other reactions.
N-Methylmorpholine is the precursor to N-Methylmorpholine N-oxide, a commercially important oxidant.
N-Methylmorpholine is used as a solvent and to make pharmaceuticals.

N-Methylmorpholine is used as a solvent and to make pharmaceuticals.
N-Methylmorpholine is an excellent solvent, emulsifier, corrosion inhibitor, Catalyst in polyurethane foamsextraction solvent, stabilizing agent for chlorinated hydrocarbons, and also can be used as pesticide intermediates.

N-Methylmorpholine is widely used in the synthesis of pesticide compounds such as insecticide, fungicide, plant growth regulator, etc.
N-Methylmorpholine is also used in the synthesis of fine chemicals such as surfactant, lubricant coolant, metal antirust agent, fiber treatment agent, etc.

N-Methylmorpholine is used as a solvent for dyes, resins, waxes and pharmaceuticals.
N-Methylmorpholine acts as a crosslinker in the preparation of polyurethane foams, elastomers and adhesives.
N-Methylmorpholine is used as a precursor to prepare N-methylmorpholine N-oxide and morpholinium cation based ionic liquids.
N-Methylmorpholine is utilized as corrosion inhibitors and anti-scaling agents in industries.

-Coatings:
N-Methylmorpholine is used as a neutralizing amine for water reducible alkyd coatings
-Pharmaceuticals:
N-Methylmorpholine serves mainly as a reagent in the synthesis of active pharmaceutical ingredients.

PREPARATION METHOD OF N-METHYLMORPHOLINE:
formaldehyde and then formic acid were slowly added dropwise to morpholine, and during the reaction, reflux was performed automatically, and CO2 was released.
Formic acid is added, heated and refluxed for 4-5 hours, then cooled, and immediately distilled by adding NaOH to collect all fractions before boiling point 99 °c, and then NaOH is added to the distillate until saturation, cooling, separation of the oil layer, drying, fractionation, collection of boiling point 114.5~117 C fraction is the finished product.

4-Methylmorpholine preparation method is to slowly add formaldehyde in morpholine drop by drop, under stirring add formic acid reaction, automatic reflux, and release carbon dioxide.
After adding formic acid, heating reflux 4 ~ 5h, cooling and adding sodium hydroxide immediately distillation, collect all the fraction before the boiling point of 99 ℃, and then add sodium hydroxide in the fraction to saturation, cooling the oil layer, drying, fractional distillation, to obtain N-methylmorpholine.

PHYSICAL and CHEMICAL PROPERTIES of N-METHYLMORPHOLINE:
Molar mass: 101.149 g·mol−1
Appearance: Liquid
Density: 0.92 g/cm3
Melting point: −66 °C (−87 °F; 207 K)
Boiling point: 115 to 116 °C (239 to 241 °F; 388 to 389 K)
Acidity (pKa): 7.38 (for the conjugate acid) (H2O)
Molecular Weight: 101.15
XLogP3: -0.3
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 0

Exact Mass: 101.084063974
Monoisotopic Mass: 101.084063974
Topological Polar Surface Area: 12.5 Å²
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 50
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Appearance Form: liquid
Odour: No data available
Odour Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: -66 °C - lit.
Initial boiling point and boiling range: 115 - 116 °C at 1000 hPa - lit.
Flash point: 12 °C - c.c.
Evaporation rate: No data available
Flammability (solid, gas): No data available

Upper/lower flammability or explosive limits:
Upper explosion limit: 11,8 %(V)
Lower explosion limit: 2,2 %(V)
Vapour pressure: No data available
Vapour density: No data available
Relative density: 0,92 g/cm3 at 25 °C
Water solubility: soluble
Partition coefficient: n-octanol/water: log Pow: -0,32 at 25 °C - Bioaccumulation is not expected.
Auto-ignition temperature: No data available
Decomposition temperature: No data available
Viscosity: No data available
Explosive properties: No data available
Oxidizing properties: No data available

Molecular Formula: C5H11NO
Molar Mass: 101.15
Density: 0.92g/mLat 25°C(lit.)
Melting Point: −66°C(lit.)
Boling Point: 115-116°C750mm Hg(lit.)
Flash Point: 75°F
Water Solubility: >500 g/L (20 ºC)
Vapor Presure: 18 mm Hg ( 20 °C)
Vapor Density: >1 (vs air)
Appearance: Liquid
Specific Gravity: 0.920 (20/4℃)
Color: Clear
Merck: 14,6277

BRN: 102719
pKa: 7.38(at 25℃)
PH: 10.6 (50g/l, H2O, 20℃)
Storage Condition: Store below +30°C.
Explosive Limit: 2.1%(V)
Refractive Index: n20/D 1.435(lit.)
Melting point: −66 °C(lit.)
Boiling point: 115-116 °C750 mm Hg(lit.)
Density: 0.92 g/mL at 25 °C(lit.)
vapor density: >1 (vs air)
vapor pressure: 18 mm Hg ( 20 °C)

refractive index: n20/D 1.435(lit.)
Flash point: 75 °F
storage temp.: Store below +30°C.
form: Liquid
pka: 7.38(at 25℃)
color: Clear
Specific Gravity: 0.920 (20/4℃)
PH: 10.6 (50g/l, H2O, 20℃)
explosive limit: 2.1%(V)
Viscosity: 0.87mm2/s
Water Solubility: >500 g/L (20 ºC)

Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.91700 to 0.92200 @ 20.00 °C.
Pounds per Gallon - (est).: 7.639 to 7.681
Refractive Index: 1.43400 to 1.43700 @ 20.00 °C.
Melting Point: 116.00 °C. @ 760.00 mm Hg
Boiling Point: 116.00 to 118.00 °C. @ 760.00 mm Hg
Boiling Point: 114.00 to 115.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 20.215000 mmHg @ 25.00 °C. (est)
Flash Point: 75.00 °F. TCC ( 23.89 °C. )
logP (o/w): -0.330
Soluble in: water, 1.00E+06 mg/L @ 25 °C (exp)

FIRST AID MEASURES of N-METHYLMORPHOLINE:
-Description of first aid measures:
*General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-METHYLMORPHOLINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in a container for disposal according to local/national regulations.

FIRE FIGHTING MEASURES of N-METHYLMORPHOLINE:
-Extinguishing media:
*Suitable extinguishing media:
Dry powder
Dry sand
-Further information:
Use water spray to cool unopened containers.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-METHYLMORPHOLINE:
-Control parameters:
--Components with workplace control parameters:
-Exposure controls:
--Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
--Personal protective equipment:
*Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,2 mm
Break through time: 30 min
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-METHYLMORPHOLINE:
-Precautions for safe handling:
Keep away from sources of ignition - No smoking.
Take measures to prevent the build up of
electrostatic charge.
-Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store in cool place.

STABILITY and REACTIVITY of N-METHYLMORPHOLINE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Incompatible materials:
No data available

SYNONYMS:
4-Methylmorpholine
N-METHYLMORPHOLINE
109-02-4
Morpholine, 4-methyl-
Methylmorpholine
1-Methylmorpholine
4-methylmorpholin
Morpholine, N-methyl-
N-methyl morpholine
4-Methylmorfolin
NSC 9382
4-methyl-morpholine
11P91ANU5X
NMM
NSC-9382
DSSTox_CID_9146
DSSTox_RID_78682
DSSTox_GSID_29146
N-Methylmorpholin
N-methyl morpholine hydrochloride
CAS-109-02-4
CCRIS 6691
EINECS 203-640-0
UN2535
Morpholinomethyl-polystyrene
UNII-11P91ANU5X
AI3-24289
4methylmorpholine
methyl-morpholine
N-methylmopholine
N-methylmorphline
N-methymorpholine
N-metylmorpholine
4-methlmorpholine
4-methylmopholine
4-methymorpholine
N-methyhnorpholine
N-methyimorpholine
Texacat NMM
4-methyimorpholine
4-Methyl-1-oxa-4-azacyclohexane
N-methyl morpholi
N-methyl-mopholine
N-methyl-morpholin
N-metyl-morpholine
4-methyl morpholin
N -methylmorpholine
N- methylmorpholine
N--methylmorpholine
N-mehtyl morpholine
N-methylmor-pholine
N-methylmorpho-line
p-Methyl morpholine
4 -methylmorpholine
4-methyl morpholine
MFCD00006175
4-N-methylmorpholine
N- methyl morpholine
N-methyl -morpholine
4-(methyl)morpholine
morpholine, 4-methyl
morphlinomethyl-polystyrene
Methylmorpholine
morpholinomethyl polystyrene
EC 203-640-0
SCHEMBL4622
WLN: T6N DOTJ A1
4-Methylmorpholine, redistilled
N-METHYLMORPHOLINE
CHEMBL2448839
DTXSID9029146
NSC9382
BCP31356
STR02354
Tox21_202412
Tox21_303402
STL294217
ZINC19230118
AKOS000118797
UN 2535
4-Methylmorpholine or n-methylmorpholine
NCGC00249222-01
NCGC00257448-01
NCGC00259961-01
BP-20398
4-Methylmorpholine, ReagentPlus(R), 99%
DB-059805
FT-0648820
FT-0658371
FT-0701320
M0370
4-Methylmorpholine, purum, >=98.0% (GC)
EN300-18961
N-Methyl morphofine pound>>Morpholine, 4-methyl-
N-Methylmorpholine, SAJ special grade, >=99.0%
J-002223
J-515790
Q2542075
F0001-0190
4-Methylmorpholine, purified by redistillation, >=99.5%
4-Methylmorpholine or n-methylmorpholine
Morpholinomethyl-polystyrene, extent of labeling: ~3.5 mmol/g base loading
4-Methylmorpholine, BioXtra, suitable for protein sequencing, >=99.5% (GC)
NMM
AKOS 89985
LUPRAGEN(R) N 105
methyl morpholine
1-Methylmorpholine
4-METHYLMORPHOLINE
N-METHYLMORPHOLINE
4-methylmorpholine
N-Methylmorpholine
N-methyl morpholine
N-Methyl morphofine
4-methylmorpholin-4-ium
4-Methyl-1-oxa-4-azacyclohexane
4-METHYL-1-OXA-4-AZACYCLOHEXANE
4-methylmorpholine hydrochloride
4-Methylmorpholine 4-Oxide
4-Methylmorpholine Oxide
4-Methylmorpholine N-Oxide
N-Methylmorpholine Oxide
N-methylmorpholine N-Oxide
NMMO
NMO
NSC 73198
NSC 82153
NMM
N-METHYLMORPHOLINE
Methylmorpholine
N-Methyl morphofine
1-Methylmorpholine
Morpholine,4-methyl-
AKOS 89985
Texacat NMM
Lupragen N105
N-Methylmorphol

N-METHYLMORPHOLINE-N-OXIDE = NMO = 4-METHYLMORPHOLINE-N-OXIDE

CAS Number: 7529-22-8
EC Number: 231-391-8
MDL number: MFCD00005947
Chemical formula: C5H11NO2

N-methylmorpholine-N-oxide (more correctly 4-methylmorpholine 4-oxide), NMO or NMMO is an organic compound.
N-methylmorpholine N-oxide is a morpholine N-oxide resulting from the oxidation of the amino group of N-methylmorpholine.
N-methylmorpholine-N-oxide can be used as is or admixed with water to form cellulose solutions from which cellulose films and fibers may be obtained.

Cellulose articles have been formed by extrusion techniques.
N-methylmorpholine-N-oxide is available commercially as the monohydrate; it has a melting point of 70 °C, and is stable under normal conditions.
N-methylmorpholine-N-oxide is soluble in polar solvents, especially water.
N-methylmorpholine-N-oxide displays characteristic reactivity with various transition metals, which undergo oxidation with this reagent.

Because of this, N-methylmorpholine-N-oxide is a preferred stoichiometric oxidant for transition metal-catalyzed oxidations.
The well-known combination of N-methylmorpholine-N-oxide and TPAP (tetrapropylammonium perruthenate) can, for example, be used in the preparation of aldehydes from primary alcohols, wherein the water produced must be taken up by molecular sieves.
The presence of water fosters an equilibrium concentration of the aldehyde hydrate, which can undergo further oxidation to the carboxylic acid.

N-methylmorpholine-N-oxide is an activated cellulose product.
N-methylmorpholine-N-oxide is soluble in water, methanol, ethanol, acetone, ethers and dimethylsulfoxide.
N-methylmorpholine-N-oxide is clear colorless to yellow solution
N-methylmorpholine-N-oxide is an organic compound used as a co-oxidant along with OsO4 and ruthenates in organic synthesis.

N-methylmorpholine-N-oxide is an organic compound used as a sacrificial catalyst and co-oxidant in oxidation reactions in organic chemistry.
N-methylmorpholine-N-oxide (NMMO) Market size was valued at USD 72.94 Million in 2021 and is projected to reach USD 115.10 Million by 2030, growing at a CAGR of 5.30% from 2023 to 2030.
Major factors which drive the market growth include the growing demand for N-methylmorpholine-N-oxide (NMMO) from solvents and pharmaceutical intermediates applications.

In addition, the rising demand for N-methylmorpholine-N-oxide (NMMO) in the Asia Pacific is anticipated to push the market growth over the forecast period.
N-methylmorpholine-N-oxide is a metabolite of Morpholine.
N-methylmorpholine-N-oxide is a morpholine N-oxide resulting from the oxidation of the amino group of N-methylmorpholine.
N-methylmorpholine-N-oxide is commercially supplied both as a monohydrate C5H11NO2.H2O and as the anhydrous compound.

USES and APPLICATIONS of N-METHYLMORPHOLINE-N-OXIDE:
This heterocyclic amine oxide and morpholine derivative, N-methylmorpholine-N-oxide, is used in organic chemistry as a co-oxidant and sacrificial catalyst in oxidation reactions for instance in osmium tetroxide oxidations and the Sharpless asymmetric dihydroxylation or oxidations with TPAP.
N-methylmorpholine-N-oxide is commercially supplied both as a monohydrate C5H11NO2·H2O and as the anhydrous compound.

The monohydrate is used as a solvent for cellulose in the lyocell process to produce cellulose fibers.
N-methylmorpholine-N-oxide is used for the treatment of autoimmune diseases and can be used as a reagent to synthesize fatty acid esters.
N-methylmorpholine-N-oxide monohydrate is used as a solvent to prepare cellulose fibers.
N-methylmorpholine-N-oxide is an oxidant and involved in the catalytic OsO4 oxidation of olefins to cis-1,2-diols.

N-methylmorpholine-N-oxide is also involved in ruthenium catalyzed oxidation of alcohols to aldehydes and ketones.
N-methylmorpholine-N-oxide is a metabolite of Morpholine (M723725).
N-methylmorpholine-N-oxide is commonly used to dissolve cellulose as well as in the dissolution of of scleroproteins.
N-methylmorpholine-N-oxide acts as a non-metallic catalyst for the cyanosilylation of ketones.

N-methylmorpholine-N-oxide is also employed as a co-oxidant for Sharpless asymmetric dihydroxylation in ionic liquids.
N-methylmorpholine-N-oxide serves as a solvent in the Lyocell process to produce tencel fiber.
Further, N-methylmorpholine-N-oxide is used in the preparation of aldehydes from primary alcohols in the presence of tetrapropylammonium perruthenate.

N-methylmorpholine-N-oxide is used as a non-metallic catalyst for the cyanosilylation of ketones.
N-methylmorpholine-N-oxide is used as a co-oxidant for Sharpless asymmetric dihydroxylation in ionic liquids.
In recent studies, N-methylmorpholine-N-oxide has been used as a catalyst in silylcyanation of aldehydes and ketones.
Lyocell, a regenerated cellulose fiber, can be prepared using N-methylmorpholine-N-oxide in an eco-friendly manner.

Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
N-methylmorpholine-N-oxide is used as a solvent for Lyocell manufacturing.
N-methylmorpholine-N-oxide is commonly used to dissolve cellulose as well as in the dissolution of of scleroproteins.

-Cosmetic Uses of N-methylmorpholine-N-oxide:
*cleansing agents
*surfactants
*surfactant - foam boosting

-Solvent of cellulose:
N-methylmorpholine-N-oxide monohydrate is used as a solvent in the lyocell process to produce lyocell fiber.
N-methylmorpholine-N-oxide dissolves cellulose to form a solution called dope, and the cellulose is reprecipitated in a water bath to produce a fiber.
The process is similar but not analogous to the viscose process.
In the viscose process, cellulose is made soluble by conversion to its xanthate derivatives.
With N-methylmorpholine-N-oxide, cellulose is not derivatized but dissolves to give a homogeneous polymer solution.
The resulting fiber is similar to viscose; this was observed, for example, for Valonia cellulose microfibrils.
Dilution with water causes the cellulose to reprecipitate, i.e. the solvation of cellulose with N-methylmorpholine-N-oxide is a water sensitive process.
Cellulose remains insoluble to most solvents since it has a strong and highly structured intermolecular hydrogen bonding network, which resists common solvents.
N-methylmorpholine-N-oxide is able to break the hydrogen bonding network that keeps cellulose insoluble to water and other solvents.
Similar solubility has been obtained in a few solvents, particularly a mix of lithium chloride in dimethyl acetamide and some hydrophilic ionic liquids.

-Dissolution of scleroproteins:
Another use of N-methylmorpholine-N-oxidev is in the dissolution of scleroprotein (found in animal tissue).
This dissolution occurs in the crystal areas which are more homogeneous and contain glycine and alanine residues with a small number of other residues.
How N-methylmorpholine-N-oxide dissolves these proteins is scarcely studied.
Other studies, however, have been done in similar amide systems (i.e. hexapeptide).
The hydrogen bonds of the amides can be broken by N-methylmorpholine-N-oxide.

OXIDANT:
N-methylmorpholine-N-oxide, as an N-oxide, is an oxidant.
N-methylmorpholine-N-oxide is generally used in stoichiometric amounts as a secondary oxidant (a cooxidant) to regenerate a primary (catalytic) oxidant after the latter has been reduced by the substrate.
Vicinal syn-dihydroxylation reactions for example, would, in theory, require stoichiometric amounts of toxic, volatile and expensive osmium tetroxide, but if continuously regenerated with N-methylmorpholine-N-oxide, the amount required can be reduced to catalytic quantities.

PURIFICATION METHODS OF N-METHYLMORPHOLINE-N-OXIDE:
When the oxide is dried for 2-3hours at high vacuum, it dehydrates.
Add MeOH to the oxide and distil off the solvent under vacuum until the temperature is ca 95o.
Then add Me2CO at reflux and cool to 20o.
The crystals are filtered off, washed with Me2CO and dried.
The degree of hydration may vary and may be important for the desired reactions.

PHYSICAL and CHEMICAL PROPERTIES of N-METHYLMORPHOLINE-N-OXIDE:
Chemical formula: C5H11NO2
Molar mass: 117.15 g/mol
Melting point: 180 to 184 °C (356 to 363 °F; 453 to 457 K)
Molecular Weight: 117.15
XLogP3-AA: -0.7
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 0
Exact Mass: 117.078978594
Monoisotopic Mass: 117.078978594
Topological Polar Surface Area: 27.3 Å²
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 78.5
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Min. Purity Spec: 97% (HPLC)
Physical Form (at 20°C): Solid
Melting Point: 72-81°C
Density: 1.14
Refractive Index: 1.422
Long-Term Storage: Store long-term at 2-8°C
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.13000 @ 25.00 °C.
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.820 (est)
Soluble in: water, 9.223e+005 mg/L @ 25 °C (est)

Molecular Weight: 117.15
CAS NO.: 7529-22-8
Assay(G.C.): ≥50%
Density: 1.25g/cm3
Boiling point: 118-119ºC
Flash point: 120℃
Physical state: solid
Color: No data available
Odor: No data available
Melting point/freezing point
Melting point/range: 180 - 184 °C - lit.
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 335 g/l at 20 °C completely soluble
Partition coefficient: n-octanol/water:
log Pow: -1,2 at 25 °C Bioaccumulation is not expected.
Vapor pressure: 1,41 hPa at 20 °C
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:
Surface tension: 68,9 mN/m at 20 °C

Molecular Weight: 117.15
Molecular Formula: C5H11NO2
Boiling Point: 118-119ºC
Melting Point: 180-184ºC
Flash Point: 118-119ºC
Purity: 95%
Density: 1.14 g/cm3
Appearance: Colourless to slightly yellow transparent liquid
Storage: Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances.
Refrigerator (approx 4ºC).
Store protected from moisture.

Melting point: 180-184 °C(lit.)
Boiling point: 118-119°C
Density: 1,14 g/cm3
vapor pressure: 1.41hPa at 20℃
refractive index: n20/D 1.43
Flash point: 118-119°C
storage temp.: 2-8°C
solubility: DMSO (Soluble), Methanol (Slightly)
pka: 4.93±0.20(Predicted)
form: Liquid
color: Clear colorless to yellow
PH: 9.00 ( in neat)
Water Solubility: Soluble in water, methanol, ethanol, acetone, ethers and dimethylsulfoxide.
BRN: 507437
Stability: Hygroscopic
LogP: -1.2 at 25℃

FIRST AID MEASURES of N-METHYLMORPHOLINE-N-OXIDE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of N-METHYLMORPHOLINE-N-OXIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.

FIRE FIGHTING MEASURES of N-METHYLMORPHOLINE-N-OXIDE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of N-METHYLMORPHOLINE-N-OXIDE:
-Control parameters:
-Ingredients with workplace control parameters:
-Exposure controls:
-Personal protective equipment:
*Eye/face protection:
Use Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Flame retardant antistatic protective clothing.
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of N-METHYLMORPHOLINE-N-OXIDE:
-Precautions for safe handling:
*Hygiene measures:
Change contaminated clothing.
Wash hands after working with substance.
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.
*Storage stability
Recommended storage temperature: 2 - 8 °C

STABILITY and REACTIVITY of N-METHYLMORPHOLINE-N-OXIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available

SYNONYMS:
4-Methylmorpholine N-oxide
7529-22-8
4-Methylmorpholine 4-oxide
N-Methylmorpholine oxide
N-Methylmorpholine N-oxide
Morpholine, 4-methyl-, 4-oxide
4-methyl-4-oxidomorpholin-4-ium
Methyl morpholine oxide
N-Methylmorpholine-N-oxide
4-Methylmorpholine-4-oxide
NMO
NMMO
4-Methylmorpholine Oxide
4-methylmorpholine-N-oxide
N-Methylmorpholine 4-oxide
MFCD00005947
ARC64PKJ0F
CHEBI:52093
4-methylmorpholin-4-ium-4-olate
NSC73198
NSC-73198
NSC-82153
Morpholine, 4-oxide
NMO solution
NSC 73198
NSC 82153
EINECS 231-391-8
UNII-ARC64PKJ0F
4-methylmorpholine 4-oxide, monohydrate
N-Methyl morpholine N-oxide
4-methyl morpholine N-oxide
4-methyl-4-oxido-morpholin-4-ium
4-methylmorpholine-4-oxide solution
n-methylmorpholineoxide
methylmorpholine N-oxide
methylmorpholine-N-oxide
4-Methylmorpholine-oxide
N-methylmorpholin-N-oxid
4methylmorpholine N-oxide
4methylmorpholine-N oxide
4methylmorpholine-N-oxide
N-methyl morpholine oxide
N-methyl morpholine-oxide
N-methyl-morpholine oxide
4-methyl morpholine oxide
N-methylmopholine N-oxide
N-methylmorphline N-oxide
N-methylmorpholin-N-oxide
N-methymorpholine N-oxide
4-methylmopholine N-oxide
4-methylmorpholin-N-oxide
4-Methylmorpholine4-oxide
4-methymorpholine N-oxide
DSSTox_CID_9287
4-methylmorpholin-4-oxide
N-methyimorpholine N-oxide
4-methylmorpholine N oxide
4-methylmorpholine-N oxide
EC 231-391-8
N-methyl morpholin-N-oxide
4-methy-morpholine-N-oxide
4-methyl morpholin N-oxide
4-methylnnorpholine N-oxide
SCHEMBL1845
N-methyl morpholine-N-oxide
N-methyl-morpholine N-oxide
N-methyl-morpholine-N-oxide
4-methyl morpholine-N-oxide
4-methyl-morpholine N-oxide
4-methyl-morpholine-N-oxide
4-methylmorpholine-N- oxide
DSSTox_RID_78750
NCIOpen2_000398
NCIOpen2_000960
4-methyl morpholine-4-oxide
4-methyl-morpholine 4-oxide
4-methyl-morpholine-4-oxide
DSSTox_GSID_29287
4-methyl-morpholine-N- oxide
CHEMBL3184330
DTXSID3029287
LFTLOKWAGJYHHR-UHFFFAOYSA-
ZINC157080
4-Methylmorpholine N-oxide, 97%
NSC82153
Tox21_200479
c1367
AKOS009159059
METHYL MORPHOLINE OXIDE
4-methyl-4-oxidanidyl-morpholin-4-ium
N-METHYLMORPHOLINE N-OXIDE
NCGC00248649-01
NCGC00258033-01
BP-30197
4-Methyl-1,4.lambda.~5~-oxazinan-4-ol
CAS-7529-22-8
CS-0016218
M0981
M2192
EN300-37514
D71257
A840005
Q416248
W-104395
4-Methylmorpholine N-oxide solution, 50 wt. % in H2O
4-Methylmorpholine N-oxide, 50 wt.% solution in water
4-methylmorpholine n-oxide (50% in water, ca. 4.8mol/l)
4-Methylmorpholine N-oxide solution, technical, ~50% in H2O
Morpholine N-oxide, polymer-bound, 50-100 mesh, extent of labeling: 2.0-3.0 mmol/g loading, 1 % cross-linked with divinylbenzene
NMO
NMMO
N-Methylmorpholine oxide

SYNONYMS4-Methylmorpholine 4-oxide monohydrate;4-Methylmorpholine-N-oxide; 4-Methylmorpholine N-oxide monohydrate; NMO monohydrate; 4-Methylmorpholin-4-oxidmonohydrat (German); 4-Oxido de 4-metilmorfolina, monohidrato (Spanish); 4-Oxyde de 4-méthylmorpholine, monohydrate (French); CAS NO:7529-22-8

SYNONYMS 4-Methylmorpholine 4-oxide monohydrate;4-Methylmorpholine-N-oxide; 4-Methylmorpholine N-oxide monohydrate; NMO monohydrate; 4-Methylmorpholin-4-oxidmonohydrat (German) CAS NO:7529-22-8

SYNONYMSMethylmorpholine 4-oxide monohydrate;4-Methylmorpholine-N-oxide; 4-Methylmorpholine N-oxide monohydrate; NMO monohydrate; 4-Methylmorpholin-4-oxidmonohydrat (German); 4-Oxido de 4-metilmorfolina, monohidrato (Spanish); 4-Oxyde de 4-méthylmorpholine, monohydrate (French); CAS NO:7529-22-8

DESCRIPTION:

N-Methylolacrylamide is a chemical compound that belongs to the group of ethylene diamines.
N-methylol Acrylamide (48% In Water) has been used as a fluorescence probe for fatty acids in polyvinyl compounds, and as an electrochemical impedance spectroscopy (EIS) substrate.
N-Methylolacrylamide also reacts with acrylamide to form polymers.

CAS Number:924-42-5
Molecular Weight:101.10
Linear Formula:CH2=CHCONHCH2OH

SYNONYM(S) OF N-METHYLOL ACRYLAMIDE (48% IN WATER):
Monomethylolacrylamide, N-(Hydroxymethyl)acrylamide, N-Methanolacrylamide, 2-Propenamide,N-(hydroxymethyl)-;Acrylamide,N-(hydroxymethyl)-;N-(Hydroxymethyl)-2-propenamide;N-Methylolacrylamide;N-Methanolacrylamide;N-(Hydroxymethyl)acrylamide;Monomethylolacrylamide;NMA 60;MH 100 (amide);MH 100;N-MAM P;U-Ramin T 80;Rocagil BT;N-MAM;NSC 553;N-NBM;Cylink NMA;N-Methylol acrylamide;NMA 48;90456-67-0;160278-55-7;176598-18-8;194091-52-6;211862-48-5;211862-50-9, N-(HYDROXYMETHYL)ACRYLAMIDE;METHYLOLACRYLAMIDE;N-MAN;N-MAN PC;NM-AMD;uraminet80;Rocagil BT;NCI-C60333;N-Methylol;Yuramin T 80

This reaction is catalyzed by hydroxyl groups on the acrylamide molecule.
The polymerization process is reversible, with the formation of monomers and dimers.
The phase transition temperature ranges from -5°C to +35°C.
Chemical stability increases with increased molecular weight, but decreases when exposed to light or air.

N-methylol Acrylamide (48% In Water) is a colorless liquid.
N-methylol Acrylamide (48% In Water) produces post-crosslinking site in polymers.
N-methylol Acrylamide (48% In Water) complies with TSCA regulation.

N-methylol Acrylamide (48% In Water) contains N-Methylol Acrylamide, offered as a 48% aqueous solution.
Its reactivity due to a bi-functional both vinyl and hydroxyl-methyl groups.
Polymers can be formed through varying conditions via emulsion, solution, or suspension techniques.

The hydroxyl-methyl groups, are self-cross-linkable under moderate conditions which can be reacted separately by varying the reaction conditions.
The hydroxyl-methyl group can be first be reacted with a substrate like cellulose and subsequently cross-linked by free radical polymerization.

APPLICATIONS OF N-METHYLOL ACRYLAMIDE (48% IN WATER):

N-methylol Acrylamide (48% In Water) is used in Adhesives
N-methylol Acrylamide (48% In Water) is used in Binders in papermaking, paper coatings
N-methylol Acrylamide (48% In Water) is used in Antistatic agents in textiles.

N-methylol Acrylamide (48% In Water) is used in Non-woven to a variety of textile finishes.
N-methylol Acrylamide (48% In Water) is used in Surface coatings resins for varnishes and paint.
N-methylol Acrylamide (48% In Water) is used in Chromatographic materials in films.

N-methylol Acrylamide (48% In Water) is used in Sizing agents.
N-methylol Acrylamide (48% In Water) is used in Preparation of latex binders and of cross-linkable emulsion.
N-methylol Acrylamide (48% In Water) is used in Industrial polymer such as, plastic, rubber, thermoplastics resins.
N-methylol Acrylamide (48% In Water) is used in Copolymer latices to develop excellent water and solvent resistance film.

CHEMICAL AND PHYSICAL PROPERTIES OF N-METHYLOL ACRYLAMIDE (48% IN WATER):
form
liquid
Quality Level
100
contains
30 ppm monomethyl ether hydroquinone as inhibitor
concentration
48 wt. % in H2O
refractive index
n20/D 1.413
density
1.074 g/mL at 25 °C
SMILES string
OCNC(=O)C=C
InChI
1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)
InChI key
CNCOEDDPFOAUMB-UHFFFAOYSA-N
CAS No
[924-42-5]
Product Code
FM180875
MDL No
MFCD00004597
MOL file
Download
Chemical Formula
C4H7NO2
Molecular Weight
101.1 g/mol
Smiles
C=CC(=O)NCO
Melting Point
-10 °C
Density
1.074 g/cm3
Appearance, Clear to slightly yellowish
Color, APHA (Pt-Co Units), max. 50
Specific gravity (25 oC), 1.0700 - 1.0900
Total solid (%), 46.0 - 52.0
Refractive index, 1.412
pH, 6.0 - 7.5
Copper content (ppm), 0.5 - 2.0
Acrylamide content (%), max. 5.0
Formaldehyde content (%), max. 2.0
MEHQ content (ppm), max. 50
Product Name:
N-Methylolacrylamide
Other Name:
2-Propenamide,N-(hydroxymethyl)-;Acrylamide,N-(hydroxymethyl)-;N-(Hydroxymethyl)-2-propenamide;N-Methylolacrylamide;N-Methanolacrylamide;N-(Hydroxymethyl)acrylamide;Monomethylolacrylamide;NMA 60;MH 100 (amide);MH 100;N-MAM P;U-Ramin T 80;Rocagil BT;N-MAM;NSC 553;N-NBM;Cylink NMA;N-Methylol acrylamide;NMA 48;90456-67-0;160278-55-7;176598-18-8;194091-52-6;211862-48-5;211862-50-9
CAS No.:
924-42-5
Molecular Formula:
C4H7NO2
InChIKeys:
InChIKey=CNCOEDDPFOAUMB-UHFFFAOYSA-N
Molecular Weight:
101.10400
Exact Mass:
101.10
EC Number:
213-103-2
UNII:
W8W68JL80Q
ICSC Number:
1637
NSC Number:
553
DSSTox ID:
DTXSID3020885
HScode:
2924199090
Categories:
Coating Additive
PSA：
49.33000
XLogP3：
-0.37070
Appearance：
N-methylolacrylamide appears as a colorless or yellow aqueous solution.
Density：
1.074
Melting Point：
74.5 °C
Boiling Point：
318.1ºC at 760mmHg
Flash Point：
146.2ºC
Refractive Index：
n20/D 1.413
Water Solubility：
Solubility in water, g/100ml at 20°C: 188
Storage Conditions：
Refrigerator
Vapor Pressure：
Vapour pressure, Pa at 25°C: 0.03 (negligible)
Air and Water Reactions：
Soluble in water.
Reactive Group：
Alcohols and Polyols
Reactivity Alerts：
Polymerizable
Reactivity Profile：
N-METHYLOLACRYLAMIDE may be sensitive to prolonged exposure to light. Polymerization and generation of heat and flames may occur on exposure to to heat or contaminants. Incompatible with strong oxidizers. (NTP, 1992)
Melting point, 74-75°C
Boiling point, 277°C(lit.)
Density, 1.082 g/mL at 20 °C
vapor pressure, 31 hPa (25 °C)
refractive index, n20/D 1.413
Flash point, 100°C
storage temp., Store at <= 20°C.
solubility, Chloroform (Slightly), Methanol (Slightly)
pka, 13.25±0.10(Predicted)
form, Solid
color, White to Off-White
Specific Gravity, 1.074
PH, 6.0-7.0 (H2O, 20°C)
Water Solubility, <0.1 g/100 mL at 20.5 ºC
BRN, 506646
Stability, Light Sensitive, Moisture Sensitive
InChIKey, CNCOEDDPFOAUMB-UHFFFAOYSA-N
LogP, -1.81 at 20℃ and pH7
Indirect Additives used in Food Contact Substances, N-METHYLOLACRYLAMIDE
FDA 21 CFR, 175.105; 176.180; 177.1010
CAS DataBase Reference, 924-42-5(CAS DataBase Reference)
EWG's Food Scores, 1
FDA UNII, W8W68JL80Q
Proposition 65 List, n-Methylolacrylamide
NIST Chemistry Reference, 2-Propenamide, n-(hydroxymethyl)-(924-42-5)
IARC, 3 (Vol. 60) 1994
EPA Substance Registry System, N-Methylolacrylamide (924-42-5)
Molecular Weight
101.10 g/mol
XLogP3-AA
-0.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
101.047678466 g/mol
Monoisotopic Mass
101.047678466 g/mol
Topological Polar Surface Area
49.3Å²
Heavy Atom Count
7
Formal Charge
0
Complexity
79.8
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

SAFETY INFORMATION ABOUT N-METHYLOL ACRYLAMIDE (48% IN WATER):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

SAFETY & HANDLING:
NMA48 is highly reactive, thus, it is essential that precautions must be taken to maintain stability during shipping and storage.
It is recommended that NMA48 is used before 12 months from the date of manufacture and should be stored in a cool place where the temperature is below 31°C.

Shelf life may be reduced if these storage are not observed.
NMA 48 is a reactive monomer.
Strict conditions should be well maintained and controlled:

PH:
As supplied, NMA 48 has a pH of 6.0 to 7.5.
Modification of the pH range can reduce the stability.
Monitoring of pH is recommended and it should be adjusted with phosphoric salt or acid.

Temperature :
NMA48 should be controlled to between below 31°C.
At temperatures below –10°C NMA48 will crystallize.
Slowly warming the product will re-dissolve the crystals.
Avoid to apply direct steam or heat.

At temperatures above 50°C (120°F), slow polymerization will be initiated over time.
At temperatures above 85°C (120°F), spontaneous polymerization may run.

Oxygen :
Dissolved oxygen will inhibit polymerization of NMA 48.

Contamination :
Peroxides such as persulfate, strong base and sulfite (under certain condition) can initiate polymerization of NMA 48.

STORAGE:
Protected from light.
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.

N-Methylolacrylamide, offered as a 48% aqueous solution, is a bifunctional monomer possessing both vinyl and hydroxymethyl groups.
N-Methylolacrylamide is a useful research chemical.
N-Methylolacrylamide is a colorless or yellow aqueous solution.

CAS Number: 924-42-5
EC Number: 213-103-2
Molecular Formula: C4H7NO2
Molecular Weight: 101.10400

Synonyms: N-(HYDROXYMETHYL)ACRYLAMIDE, METHYLOLACRYLAMIDE, N-MAN, N-MAN PC, NM-AMD, uraminet80, Rocagil BT, NCI-C60333, N-Methylol, Yuramin T 80, N-(HYDROXYMETHYL)ACRYLAMIDE, N-Methylolacrylamide, 924-42-5, Methylolacrylamide, N-Methylol Acrylamide, N-Methanolacrylamide, Monomethylolacrylamide, 2-Propenamide, N-(hydroxymethyl)-, Acrylamide, N-(hydroxymethyl)-, N-Hydroxymethyl acrylamide, Uramine T 80, N-(hydroxymethyl)prop-2-enamide, N-(Hydroxymethyl)-2-propenamide, Hydroxymethylacrylamide, NCI-C60333, N-MAM, NSC 553, Yuramin T 80, W8W68JL80Q, CHEBI:82492, NSC-553, MFCD00004597, N-Methyloacrylamide, CCRIS 2380, HSDB 4361, NM-AMD, EINECS 213-103-2, BRN 0506646, UNII-W8W68JL80Q, AI3-25447, ROCAGIL BT, EC 213-103-2, N-(hydroxymethyl) acrylamide, SCHEMBL25806, METHYLOLACRYLAMIDE, N-, NSC553, CHEMBL1892361, DTXSID3020885, N-METHYLOLACRYLAMIDE [IARC], AKOS006222324, CS-W013710, NCGC00163845-01, NCGC00163845-02, BS-17859, N-(HYDROXYMETHYL)ACRYLAMIDE [HSDB], FT-0720637, M0574, C19456, E78933, EN300-7474805, A844235, W-100289, Q26840808, N-(Hydroxymethyl)acrylamide 100 microg/mL in Acetonitrile, InChI=1/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7, 2-Propenamide,N-(hydroxymethyl)-, Acrylamide,N-(hydroxymethyl)-, N-(Hydroxymethyl)-2-propenamide, N-Methylolacrylamide, N-Methanolacrylamide, N-(Hydroxymethyl)acrylamide, Monomethylolacrylamide, NMA 60, MH 100 (amide), MH 100, N-MAM P, U-Ramin T 80, Rocagil BT, N-MAM, NSC 553, N-NBM, Cylink NMA, N-Methylol acrylamide, NMA 48, 90456-67-0, 160278-55-7, 176598-18-8, 194091-52-6, 211862-48-5, 211862-50-9, n-(hydroxymethyl)-2-propenamide, N-methanolacrylamide, Monomethylolacrylamide, NCI-C60333, Uramine T 80, Acrylamide, N-(hydroxymethyl)-, Monomethylolacrylamide, N-(Hydroxymethyl)acrylamide, N-Methanolacrylamide, N-Methylolacrylamide, Uramine T 80, Yuramin T 80, Methylolacrylamide, N-(Hydroxymethyl)-2-propenamide, NCI-C60333, N-Methyloacrylamide, NM-AMD, NSC 553, N-MAM, 2-Propenamide, N-(hydroxymethyl)-, Acrylamide, N-(hydroxymethyl)-, N-(Hydroxymethyl)-2-propenamide, N-Methylolacrylamide, N-Methanolacrylamide, N-(Hydroxymethyl)acrylamide, Monomethylolacrylamide, NMA 60, MH 100 (amide), MH 100, N-MAM P, U-Ramin T 80, Rocagil BT, N-MAM, NSC 553, N-NBM, Cylink NMA, N-Methylol acrylamide, NMA 48, 2-Propenamide,N-(hydroxymethyl)-, Acrylamide, N-(hydroxymethyl), Monomethylolacrylamide, n-(hydroxymethyl)-2-propenamid, n-(hydroxymethyl)-acrylamid, NCI-C60333, NM-AMD, N-Methanolacrylamide, Acrylamide, N-(hydroxymethyl, Monomethylolacrylamide, N-(Hydroxymethyl)acrylamide, N-Methanolacrylamide, N-Methylolacrylamide, Uramine T 80, Yuramin T 80, Methylolacrylamide, N-(Hydroxymethyl)-2 propenamide, NCI-C60333, N-Methyloacrylamide, NM-AMD, NSC 553, N-MAM, N-Methylolacrylamide, Acrylamide, N-(hydroxymethyl)-, N-(Hydroxymethyl) acrylamide, N-(Hydroxymethyl)-2-propenamide, N-Methanolacrylamide, Monomethylolacrylamide NMA, 2-Propenamide, N-(hydroxymethyl)-

N-Methylolacrylamide appears as a colorless or yellow aqueous solution.
N-Methylolacrylamide is a secondary carboxamide.
N-Methylolacrylamide is a bifunctional monomer possessing both vinyl and hydroxymethyl groups.

Thermoplastic polymers can be formed through the copolymerization of NMA with a variety of vinyl monomers via emulsion, solution, or suspension techniques.
The resulting products, having pendant hydroxymethyl groups, are self-crosslinkable under moderate conditions.
This mechanism permits the conversion of thermoplastic backbone polymers to thermoset materials at the point of use without the need for an external crosslinker.

Conversely, the hydroxymethyl group can first be reacted with a substrate like cellulose and subsequently cross-linked by free radical polymerization.
N-Methylolacrylamide is a white solid

N-Methylolacrylamide is a secondary carboxamide.
N-Methylolacrylamide is a colorless or yellow aqueous solution.

N-Methylolacrylamide appears as a colorless or yellow aqueous solution.
N-Methylolacrylamide is a chemical compound that belongs to the group of ethylene diamines.

N-Methylolacrylamide appears as a colorless or yellow aqueous solution.
N-Methylolacrylamide is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

N-Methylolacrylamide is a useful research chemical.
N-Methylolacrylamide is a colorless or yellow aqueous solution.

N-Methylolacrylamide is soluble in water.
N-Methylolacrylamide appears as a colorless or yellow aqueous solution.

N-Methylolacrylamide is a secondary carboxamide.
N-Methylolacrylamide is a white solid

N-Methylolacrylamide, offered as a 48% aqueous solution, is a bifunctional monomer possessing both vinyl and hydroxymethyl groups.
Thermoplastic polymers can be formed through the copolymerization of NMA with a variety of vinyl monomers via emulsion, solution, or suspension techniques.

The resulting products, having pendant hydroxymethyl groups, are self-crosslinkable under moderate conditions.
This mechanism permits the conversion of thermoplastic backbone polymers to thermoset materials at the point of use without the need for an external crosslinker.
Conversely, the hydroxymethyl group can first be reacted with a substrate like cellulose and subsequently cross-linked by free radical polymerization.

N-Methylolacrylamide, offered as a 48% aqueous solution, is a bifunctional monomer containing both vinyl and hydroxymethyl groups.

N-Methylolacrylamide is specifically designed to provide effective self-crosslinking performance along with significant reduction of both formaldehyde present in the resulting emulsion polymer and formaldehyde released to the environment during cure.
N-Methylolacrylamide combines the cost effectiveness of N-Methylolacrylamide with a drastic reduction in total formaldehyde.

The active self-crosslinking species of AEROTEX NMA is N-methylolacrylamide (NMA).
NMA contains a vinyl group and an N-methylol group.

The vinyl group is reactive and allows NMA to be easily incorporated into a variety of polymer structures.
Once incorporated into the polymer, the methylol group can be activated to cross-link with itself, with other functional groups in the polymer (such as hydroxyls or amines), or with cellulosic substrates.
The bifunctional feature of N-Methylolacrylamide ultimately results in latex binders which provide important performance properties to the final product, such as wet strength, tear strength, and solvent resistance.

AEROTEX NMA Monomer (ROW) by allnex is N-methylolacrylamide based monomer.
N-Methylolacrylamide is specifically designed to provide effective self-crosslinking performance together with a significant reduction in both the formaldehyde present in the resulting emulsion polymer and the formaldehyde released to the environment upon curing.
N-Methylolacrylamide's bifunctional feature results in latex binders which provide important performance properties to the final product such as solvent resistance, wet- and tear strength.

AEROTEX NMA Monomer (ROW) is used as binders in papermaking, textiles & non-wovens to a variety of surface coatings and resins for varnishes, films and sizing agents.
The shelf life of N-Methylolacrylamide is 240 days.

Applications of N-Methylolacrylamide:
N-Methylolacrylamide has been used as a fluorescence probe for fatty acids in polyvinyl compounds, and as an electrochemical impedance spectroscopy (EIS) substrate.
N-Methylolacrylamide also reacts with acrylamide to form polymers. This reaction is catalyzed by hydroxyl groups on the acrylamide molecule.

Applications Areas:
The applications of N-Methylolacrylamide range from adhesives and binders in papermaking, textiles, and non-wovens to a variety of surface coatings and resins for varnishes, films and sizing agents.

Uses of N-Methylolacrylamide:
Starch modifier; reactive comonomer for vinyl acetate, SB resins.
N-Methylolacrylamide is used coating auxiliary agents, electronics chemicals, leather auxiliary agents, petroleum additives, plastic auxiliary agents, rubber auxiliary agents, surfactants, textile auxiliary agents

N-Methylolacrylamide is used in formulation or re-packing, at industrial sites and in manufacturing.
N-Methylolacrylamide is used in the following products: polymers.
N-Methylolacrylamide has an industrial use resulting in manufacture of another substance (use of intermediates).

N-Methylolacrylamide is used in the following areas: agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.
N-Methylolacrylamide is used for the manufacture of: chemicals and textile, leather or fur.

Release to the environment of N-Methylolacrylamide can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.

Release to the environment of N-Methylolacrylamide can occur from industrial use: manufacturing of the substance.
N-Methylolacrylamide is used Chemical intermediate, reactive comonomer; production of polymers for coatings, varnishes, and adhesion; crease resistance in cotton material.

N-Methylolacrylamide has been used as a fluorescence probe for fatty acids in polyvinyl compounds, and as an electrochemical impedance spectroscopy (EIS) substrate.
N-Methylolacrylamide also reacts with acrylamide to form polymers. This reaction is catalyzed by hydroxyl groups on the acrylamide molecule.

The polymerization process is reversible, with the formation of monomers and dimers.
The phase transition temperature ranges from -5°C to +35°C.
Chemical stability increases with increased molecular weight, but decreases when exposed to light or air.

Handling and Storage of N-Methylolacrylamide:

Precautions for safe handling:

Advice on safe handling:
Work under hood.

Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.

N-Methylolacrylamide is highly reactive, thus, it is essential that precautions be taken to maintain stability during shipping and storage.
The stability of the solution is dependent mainly upon oxygen level, contaminants, storage temperature, and pH.

N-Methylolacrylamide has a shelf life of 270 days from the date of manufacture and should be stored in a cool place where the temperature range is between 0°C and 29°C.
The expiration date may be extended and COA updated after QC testing of retained samples, only for material in allnex possession.

Storage class:
Storage class (TRGS 510): 6.1D: Non-combustible

Stability and Reactivity of N-Methylolacrylamide:

Reactivity:
No data available

Reactivity Profile:
N-Methylolacrylamide may be sensitive to prolonged exposure to light.
Polymerization and generation of heat and flames may occur on exposure to to heat or contaminants.
Incompatible with strong oxidizers.

Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).

Contains the following stabilizer(s):
Hydroquinone monomethyl ether (30 ppm)

Conditions to avoid:
No information available

First Aid Measures of N-Methylolacrylamide:

General advice:
Show this material safety data sheet to the doctor in attendance.

If inhaled:
After inhalation:
Fresh air.
Call in physician.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.

In case of eye contact:
After eye contact:
Rinse out with plenty of water.

Call in ophthalmologist.
Remove contact lenses.

If swallowed:
Give water to drink (two glasses at most).
Seek medical advice immediately.

Indication of any immediate medical attention and special treatment needed:
No data available

Fire Fighting Measures of N-Methylolacrylamide:

Extinguishing media:

Suitable extinguishing media:
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.

Exposure Controls/Personal Protection of N-Methylolacrylamide:

Personal protective equipment:

Eye/face protection:
Use equipment for eye protection.
Safety glasses

Body Protection:
protective clothing

Respiratory protection:
Recommended Filter type: Filter type ABEK

Control of environmental exposure:
Do not let product enter drains.

Accidental Release Measures of N-Methylolacrylamide:

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.

Observe possible material restrictions.
Take up carefully with liquid-absorbent material.

Dispose of properly.
Clean up affected area.

Identifiers of N-Methylolacrylamide:
Molecular Weight: 101.10400
Exact Mass: 101.10
EC Number: 213-103-2
UNII: W8W68JL80Q
ICSC Number: 1637
NSC Number: 553
DSSTox ID: DTXSID3020885
HScode: 2924199090
PSA: 49.33000
XLogP3: -0.37070
Density: 1.074
Melting Point: 74.5 °C
Boiling Point: 318.1ºC at 760mmHg
Flash Point: 146.2ºC
Refractive Index: n20/D 1.413

Properties of N-Methylolacrylamide:
CBNumber: CB3182194
Molecular Formula: C4H7NO2
Molecular Weight: 101.1
MDL Number: MFCD00004597
MOL File: 924-42-5.mol
Melting point: 74-75°C
Boiling point: 277°C(lit.)
Density: 1.082 g/mL at 20 °C
vapor pressure: 31 hPa (25 °C)
refractive index: n20/D 1.413
Flash point: 100°C
storage temp.: Store at <= 20°C.
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 13.25±0.10(Predicted)
form: Solid
color: White to Off-White
Specific Gravity: 1.074
PH: 6.0-7.0 (H2O, 20°C)
Water Solubility: BRN: 506646
Stability: Light Sensitive, Moisture Sensitive

InChIKey: CNCOEDDPFOAUMB-UHFFFAOYSA-N
LogP: -1.81 at 20℃ and pH7
Indirect Additives used in Food Contact Substances: N-METHYLOLACRYLAMIDE
FDA 21 CFR: 175.105; 176.180; 177.1010
CAS DataBase Reference: 924-42-5(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: W8W68JL80Q
Proposition 65 Lis: n-Methylolacrylamide
NIST Chemistry Reference: 2-Propenamide, n-(hydroxymethyl)-(924-42-5)
EPA Substance Registry System: N-Methylolacrylamide (924-42-5)
Molecular Weight: 101.10 g/mol

XLogP3-AA: -0.5
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 2
Exact Mass: 101.047678466 g/mol
Monoisotopic Mass: 101.047678466 g/mol
Topological Polar Surface Area: 49.3Å²
Heavy Atom Count: 7
Complexity: 79.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Water Solubility: Solubility in water, g/100ml at 20°C: 188
Storage Conditions: Refrigerator
Vapor Pressure: Vapour pressure, Pa at 25°C: 0.03 (negligible)
Air and Water Reactions: Soluble in water.
Reactive Group: Alcohols and Polyols
Reactivity Alerts: Polymerizable
Chemical Name: N-(Hydroxymethyl)acrylamide
CAS Number: 924-42-5
Molecular Formula: C₄H₇NO₂
Appearance: White to Off-White Solid
Melting Point: 74-76°C
Molecular Weight: 101.1
Storage: -20°C
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: Light Sensitive, Moisture Sensitive
Physical state: liquid
Color: colorless, yellow
Odor: formaldehyde-like
Melting point/freezing point:
Melting point/range: -10 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available

Upper/lower flammability or explosive limits: No data available
Flash point: > 93 °C - closed cup
Autoignition temperature: Not applicable
Decomposition temperature: No data available
pH: 6,0 - 7,0
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility at 20 °C soluble
Partition coefficient n-octanol/water: No data available
Vapor pressure 31,68 hPa at 25 °C
Density 1,074 g/cm3 at 25 °C
Relative density No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available
Density: 1.074
Boiling Point: 318.1±34.0 °C at 760 mmHg

Melting Point: 74-75°C
Molecular Formula: C4H7NO2
Molecular Weight: 101.104
Flash Point: 146.2±25.7 °C
Exact Mass: 101.047676
PSA: 49.33000
LogP: -1.48
Vapour Pressure: 0.0±1.5 mmHg at 25°C
Index of Refraction: 1.459
Storage condition: Refrigerator
Water Solubility: Melting Point: 76°C
Color: White
UN Number: 3531
Formula Weight: 101.11
Percent Purity: ≥98.0% (T)
Physical Form: Crystalline Powder
Chemical Name or Material: N-(Hydroxymethyl)acrylamide

Appearance: Clear to slightly hazy liquid
Color: Yellow to pink
Color, APHA: ≤ 40
Total solids, % by weight: 46 - 50
Free formaldehyde, % by weight: ≤ 0.25
Copper in solution, ppm: ≤ 2.5
MEHQ inhibitor, ppm: 30 ± 5
pH: 5.5 - 7.0
Specific Gravity at 25°C: 1.05 g/ml

SYNONYMS 1-Octanecarboxylic acid; n-Pelargonic Acid; Nonanoic Acid; 1-octanecarboxylic Acid; Nonylic Acid; Acide Nonylique Normal; Acide Pelargonique; Hexacid C-9; Octane-1-carboxylic Acid; Pelargic Acid CAS NO. 112-05-0

SYNONYMS 4-Methylmorpholine 4-oxide monohydrate;4-Methylmorpholine-N-oxide; 4-Methylmorpholine N-oxide monohydrate; NMO monohydrate; 4-Methylmorpholin-4-oxidmonohydrat (German); 4-Oxido de 4-metilmorfolina, monohidrato (Spanish); 4-Oxyde de 4-méthylmorpholine, monohydrate (French); CAS NO:7529-22-8, 70187-32-5

1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone CAS NO:2687-94-7

CASTOR OIL NO. 1 AND BP; castor oil; cosmetol; neoloid; ricirus oil; palma christi oil; phorbyol; fixed oil obtained from the seeds of castor, ricinus communis, euphorbiaceae CAS NO:8001-79-4

N-Octadecanol is waxy solid alcohol formerly obtained from whale or dolphin oil and used as a lubricant and antifoam agent and to retard evaporation of water from reservoirs.
N-Octadecanol is used as an opacifying agent and foaming surfactant, as well as an aqueous and non-aqueous viscosity increasing agent.
N-Octadecanol is a vegetable-derived ingredient that's naturally found in plants, insects, and even humans.

CAS Number: 112-92-5
EC Number: 204-017-6
Chemical Formula: C18H38O
Molar Mass: 270.49 g/mol

N-Octadecanol is a compound produced from stearic acid, a naturally occurring fatty acid.
N-Octadecanol consists predominantly of cetyl and N-Octadecanols and is classified as a fatty alcohol.

N-Octadecanol is used as an opacifying agent and foaming surfactant, as well as an aqueous and non-aqueous viscosity increasing agent.
N-Octadecanol provides an emollient feel to the skin and can be used in water-in-oil emulsions, oil-in-water emulsions, and anhydrous formulations.

N-Octadecanol is widely used in conditioners and other cosmetic products due to N-Octadecanol emollient properties.
Use N-Octadecanol 1% to 25% by weight inclusion.

N-Octadecanol itself is not an emulsifier, but must be combined with another emulsifier.
The appearance of N-Octadecanol can be pastel or flake.

N-Octadecanol is waxy solid alcohol formerly obtained from whale or dolphin oil and used as a lubricant and antifoam agent and to retard evaporation of water from reservoirs.
N-Octadecanol is now manufactured by chemical reduction of stearic acid.

N-Octadecanol is an organic compound, usually appearing in the form of white crystalline granules, derived from fats and oils.

N-Octadecanol is in a class known as fatty alcohols, which, unlike irritating types of alcohols, do not dry out skin.
N-Octadecanol is typically produced through hydrogenation (process change from a liquid into a solid or semi-solid state) of stearic acid.

N-Octadecanol is a saturated fatty acid prevalent in animal fats, but rich plant sources of stearic acid include palm fruit, cocoa butter and shea butter.
The N-Octadecanol we use is derived from plant (non-animal) sources.

N-Octadecanol can be used in personal care products as an emollient, helping to nourish skin and hair, leaving them soft and smooth.
N-Octadecanol also has emulsion stabilizing properties, and can be used to help balance and add structure to oil-water formulations.

N-Octadecanol is a long-chain primary fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of 18 carbon atoms.
N-Octadecanol has a role as a plant metabolite, a human metabolite and an algal metabolite.

N-Octadecanol is a long-chain primary fatty alcohol, a fatty alcohol 18:0 and a primary alcohol.
N-Octadecanol derives from a hydride of an octadecane.

N-Octadecanol is a natural product found in Mikania cordifolia, Stoebe vulgaris, and other organisms with data available.

N-Octadecanol is a vegetable-derived ingredient that's naturally found in plants, insects, and even humans.
Per our point about not all alcohols being the same, those used in skincare typically fall into one of two categories.
N-Octadecanol is a long-chained fatty alcohol, which differs from volatile alcohols, such as denatured alcohol (also known as alcohol denat), isopropyl alcohol, and SD alcohol.

The latter are fast-drying and cooling and evaporate as soon as they're applied onto the skin.
N-Octadecanol is often used as astringents, preservatives, or solvents.

N-Octadecanol is a thickener of cosmetic products, mainly creams and lotions.
A natural alcohol which is derived from Vegetable source, N-Octadecanol changes the viscosity and adds a to creams and lotions, whilst adding stability

N-Octadecanol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.
N-Octadecanol is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

N-Octadecanol is palm oil-derived N-Octadecanol.
N-Octadecanol is a fatty alcohol sold in flakes, pastilles and beads available in grade and kosher preparations.

N-Octadecanol can be natural, derived from plant-based oils like palm or coconut, or they can be synthetic.
N-Octadecanol is act as emulsifiers, emollients, viscosity controllers and dispersants.
N-Octadecanol is used as chemical intermediates, most often used in surfactants to enhance foaming and cleaning properties in detergents and cleaners.

N-Octadecanol is used as a nonionic surfactant and intermediate in the manufacture of plastics, textiles and waxes.
N-Octadecanol is also used as an ingredient in various lubricants, perfumes, personal care products and more.
N-Octadecanol is manufactured from renewable palm oil sources, without the use of GMOs.

N-Octadecanol is made from a minimum 98 percent C18 and no more than 2 percent C16.
N-Octadecanol has a maximum acid value of 0.5, a maximum saponification value of 1.0 and a maximum iodine value of 2.0.

Testing is performed to AOCS standards ensuring accuracy and exceptional quality control.
Great care has been taken to ensure our product is safe to use in cosmetics and other applications.

N-Octadecanol is free from peanuts, tree nuts, dairy, gluten and other common allergens.
N-Octadecanol contains no residual solvents and is bovine spongiform encephalopathy/transmissible spongiform encephalopathy (BSE/TSE) free.
Also, N-Octadecanol is not tested on animals and is REACH registered.

N-Octadecanol is a fatty alcohol used as an emollient and to help keep other ingredients intact in a formulation.
N-Octadecanol is not to be confused with the drying, irritating types of alcohol such as SD alcohol or denatured alcohol.
N-Octadecanol also has cleansing and foam-boosting properties and isn’t considered drying on skin.

N-Octadecanol in its raw form is a white, waxy substance.
The U.S. Food and Drug Administration has ruled N-Octadecanol safe as a food additive, and the independent Cosmetic Ingredient Review panel deems N-Octadecanol safe as used in cosmetics.

N-Octadecanol is a vegetable-based, highly refined fatty alcohol.

N-Octadecanol is a vegetable-based, refined fatty alcohol.
N-Octadecanol is an all-purpose, vegetable sourced, all natural and from from sustainable coconut oils.

N-Octadecanol is a very effective stabilizer, thickening agent, emulsifier, for making all kinds of lotions and creams, body butters and more.
Like other fatty alcohols stearyl is an excellent natural thickener and emulsifier or co emulsifier, and imparts a nice smooth feel.
N-Octadecanol is a very useful additive in creams, lotions and more, as a secondary emulsifier, thickener, emollient, and is compatible with nearly all cosmetic ingredients.

Compared to other fatty alcohols, like cetyl alcohol, in many formulations, the N-Octadecanol will result in a slightly more softer, conditioned feel, and after-feel sensory wise, and a whiter appearance.

N-Octadecanol is a 100% natural, vegetable derived fatty alcohol, used widely in the cosmetic and personal care industry.
N-Octadecanol is commonly used to form emulsions and is used as a conditioner, emollient, emulsifier and thickener in many cosmetic and personal care products.

As an emulsifier, N-Octadecanol helps to bind and keep product ingredients from separating (oil and water), as well as giving products better spreadability.
As a thickening agent and surfactant, N-Octadecanol helps to increase the viscosity (thickness) of N-Octadecanol and can also increase the foaming capacity.

N-Octadecanol has emollient properties and also can function as an emulsifier and thickener in products.
In stick products, such as deodorants and antiperspirants, N-Octadecanol helps to emulsify the active ingredient and fragrance into the wax base.
N-Octadecanol also helps modify the physical texture of the stick’s waxy base.

N-Octadecanol is a compound produced from stearic acid, a naturally occurring fatty acid.
N-Octadecanol is found naturally in various mammalian tissues.

N-Octadecanol is used in the biosynthesis of lipids and other naturally occurring cellular constituents and enters metabolic pathways for energy production.
In the pharmaceutical and cosmetics industries N-Octadecanol can be used as an emulsion stabilizer, fragrance ingredient, surfactant/emulsifying agent, foam booster, and as a viscosity increasing agent.

N-Octadecanol is found as an ingredient of hydrophilic ointments and petrolatums, and is also used in the preparation of creams.
N-Octadecanol appears to be poorly absorbed from the gastrointestinal tract.

N-Octadecanol is an organic compound classified as a saturated fatty alcohol with the formula CH3(CH2)16CH2OH.
N-Octadecanol takes the form of white granules or flakes, which are insoluble in water.

N-Octadecanol has a wide range of uses as an ingredient in lubricants, resins, perfumes, and cosmetics.
N-Octadecanol is used as an emollient, emulsifier, and thickener in ointments, and is widely used as a hair coating in shampoos and hair conditioners.

Stearyl heptanoate, the ester of N-Octadecanol and heptanoic acid (enanthic acid), is found in most cosmetic eyeliners.
N-Octadecanol has also found application as an evaporation suppressing monolayer when applied to the surface of water.

N-Octadecanol is prepared from stearic acid or some fats by the process of catalytic hydrogenation.
N-Octadecanol has low toxicity.

N-Octadecanol is one of the most promising fatty alcohols to be used for food applications as an oil-structuring agent.
Shows peanut oil containing 2.0%, 2.5%, and 3.0% of N-Octadecanol (C18OH).

The minimum gelling concentration (MGC), that is the lowest concentration that is permitted to obtain a self-standing material, is 2.5% (w/w). As described by Valoppi et al. (2017), the MGC depends on the chain length of the fatty alcohol and decreases as the chain length of fatty alcohols increases.
The MGC is also affected by the cooling rate applied: upon fast cooling, the ability of molecules to gel is reduced with a concomitant increase of the MGC.

For instance, the MGC of N-Octadecanol in peanut oil increases from 2.5% to 7.0% (w/w) upon cooling at 5 and 40°C/min, respectively.
This is due to the changes in crystal size and morphology as a consequence of the cooling rate used during oleogel preparation.

N-Octadecanol is evident that a slow cooling rate (5°C/min) of oil with 5% of C18OH leads to the formation of crystal structures 10 times larger than at a fast cooling rate (40°C/min).
Similar results were obtained for C16OH-, C20OH-, and C22OH-containing oleogels.

Uses of N-Octadecanol:
N-Octadecanol is used as a substitute for cetyl alcohol in pharmaceutical dispensing.
N-Octadecanol is used in cosmetic creams and perfumery.

N-Octadecanol is used in textile oils and finishes.
N-Octadecanol is used as an antifoam agent; and in lubricants, resins, and surface active agents.

Synthetic N-Octadecanol has been approved as a direct and indirect food additive ingredient and as an ingredient in over-the-counter drugs.
Substitute for cetyl alcohol in pharmaceutical dispensing, in cosmetic creams, for emulsions, textile oils and finishes.

N-Octadecanol is used as antifoam agent, lubricant, and chemical raw material.
N-Octadecanol is used in perfumery, cosmetics, intermediate, surface active agents, lubricants, resins, antifoam agent.
N-Octadecanol is used in antifoam agent.

N-Octadecanol is used in resins, and USP ointments.
Synthetic N-Octadecanol has been approved as a direct and indirect food additive ingredient and as an ingredient in over-the-counter drugs.

Widespread uses by professional workers:
N-Octadecanol is used in the following products: lubricants and greases, coating products, biocides (e.g. disinfectants, pest control products), fillers, putties, plasters, modelling clay, adhesives and sealants, non-metal-surface treatment products, washing & cleaning products, air care products, anti-freeze products and welding & soldering products.
N-Octadecanol is used in the following areas: building & construction work and agriculture, forestry and fishing.

N-Octadecanol is used for the manufacture of: , mineral products (e.g. plasters, cement), machinery and vehicles, rubber products and plastic products.
Other release to the environment of N-Octadecanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industrial sites:
N-Octadecanol is used in the following products: lubricants and greases, fillers, putties, plasters, modelling clay, coating products, adhesives and sealants, non-metal-surface treatment products and pH regulators and water treatment products.
N-Octadecanol is used in the following areas: building & construction work and mining.

N-Octadecanol is used for the manufacture of: chemicals, , mineral products (e.g. plasters, cement) and machinery and vehicles.
Release to the environment of N-Octadecanol can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release and as processing aid.

Industry Uses:
Antioxidant
Cleaning agent
Defoamer
Emulsifier
Fuel
Intermediate
Lubricants and lubricant additives
Lubricating agent
Monomers
Not Known or Reasonably Ascertainable
Other
Other (specify)
Paint additives and coating additives not described by other categories
Processing aids not otherwise specified
Solubility enhancer
Solvent
Surfactant (surface active agent)
Viscosity modifiers

Consumer Uses:
N-Octadecanol is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products), coating products, anti-freeze products, finger paints, lubricants and greases and polishes and waxes.
Other release to the environment of N-Octadecanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Other Consumer Uses:
Cleaning agent
Emulsifier
Fuel
Lubricating agent
Not Known or Reasonably Ascertainable
Other
Other (specify)
Paint additives and coating additives not described by other categories
Pigment
Solvent
Surfactant (surface active agent)

Industrial Processes with risk of exposure:
Textiles (Printing, Dyeing, or Finishing)

Applications of N-Octadecanol:
N-Octadecanol is most commonly used in all kinds of cosmetic products.
N-Octadecanol can also be successfully used in other industrial sectors.

N-Octadecanol is found in a number of detergents – N-Octadecanol is responsible for foam stabilisation in products intended for cleaning hard surfaces.
In the pulp and paper industry, N-Octadecanol is a component of emulsion skimmers.
N-Octadecanol is a component of processing fluids, and in the paint and varnish industry serves as a component of open-time regulators.

Benefits of N-Octadecanol:

Benefits for Skin:
On the flip side, because N-Octadecanol is a fatty alcohol, N-Octadecanol is not drying, non-irritating, and usually beneficial when used consistently.
N-Octadecanol acts as an emollient, leaving the skin feeling smooth and soft by forming a protective layer on the surface and helping to prevent moisture loss.
N-Octadecanol is often combined with cetyl alcohol (another fatty alcohol) to create N-Octadecanol, which also has emollient properties.

The primary reason N-Octadecanol shows up in skincare products has more to do with formulation reasons and N-Octadecanol ability to act as an emulsifier, ensuring that oil and water can be blended so that products ultimately feel thicker and more cosmetically pleasing.

Functions of N-Octadecanol:
N-Octadecanol is a popular alcohol added to many cosmetic formulations.
N-Octadecanol action is based on the function of the solvent of active substances, the function of a preservative or emulsifier.

Moreover, N-Octadecanol has other important functions in cosmetic products:

Bodying agent:
As a substance with emulsion stabilising properties, N-Octadecanol gives the desired form of a cosmetic product.
N-Octadecanol is responsible for the stabilisation of oil-in-water emulsions, water-in-oil emulsions and water-free formulations.

N-Octadecanol directly affects the viscosity of a product, giving N-Octadecanol appropriate performance and application properties.
Fatty alcohols, which include cetyl alcohol and N-Octadecanol, are designed to stabilise the emulsion, i.e., prevent N-Octadecanol from delaminating into water and oily components.
N-Octadecanol also provides and improves spreadability and can support foaming.

Emollient:
N-Octadecanol is included in a range of cosmetics designed for skin and hair care.
N-Octadecanol creates a so-called occlusive layer on the surface.

N-Octadecanol prevents excessive evaporation of water, thus keeping skin and hair soft and smooth.
For this reason, N-Octadecanol is dedicated primarily for use on dry skin.

As an emollient, N-Octadecanol is indirectly also a cosmetic ingredient with a moisturising effect.
N-Octadecanol reduces the drying effect of anionic surfactants – leaves the skin moisturised and covered with a protective layer.

Regreasing substance:
Cleansing cosmetic products remove sebum and epidermal fatty substances from the skin surface.
While N-Octadecanol is desirable to thoroughly clean the skin, N-Octadecanol also allows unwanted substances from the environment to penetrate into the deeper layers of the skin.
For this reason, regreasing substances, such as N-Octadecanol, are commonly added to cosmetics, creating a specific protective layer.

Emulsifying:
Promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil).

Emulsion stabilising:
Promotes the emulsification process and improves the stability and shelf life of the emulsion.

Foam boosting:
Improves the quality of the foam produced by increasing one or more of the following properties: volume, texture and/or stability.

Masking:
Reduces or inhibits the odor or basic taste of the product.

Opacifying:
Reduces transparency or translucency of cosmetics.

Refatting:
Restores lipids in hair or in upper layers of the skin.

Surfactant:
Reduces the surface tension of cosmetics and contributes to the even distribution of N-Octadecanol when it is used.

Viscosity controlling:
Increases or decreases the viscosity of cosmetics.

Cosmetic products containing N-Octadecanol:
Hair shampoos,
Hair conditioners,
Cleansing milks and oils,
Shower gels,
Body lotions,
Hand and foot creams,
Aftershave creams,
Body scrubs,
Self-tanners,
Anti-wrinkle creams,
Hair removal preparations,
Mascaras,
Lip balms,
Anti-acne preparations.

Characteristics of N-Octadecanol:
N-Octadecanol is the name given by the INCI (International Nomenclature of Cosmetic Ingredients) to a compound non-ionic surfactant that is a mixture of cetyl alcohol and N-Octadecanol.
Both of these alcohols are fatty alcohols.

Manufacturing Methods of N-Octadecanol:
N-Octadecanol is prepared commercially via Ziegler aluminum alkyl hydrolysis or the catalytic, high-pressure hydrogenation of stearyl acid, followed by filtration and distillation.
N-Octadecanol may also be derived from natural fats and oils.

General Manufacturing Information of N-Octadecanol:

Industry Processing Sectors:
All Other Basic Organic Chemical Manufacturing
All Other Chemical Product and Preparation Manufacturing
Fabricated Metal Product Manufacturing
Machinery Manufacturing
Mining (except Oil and Gas) and support activities
Not Known or Reasonably Ascertainable
Oil and Gas Drilling, Extraction, and Support activities
Other (requires additional information)
Paint and Coating Manufacturing
Paper Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Petrochemical Manufacturing
Petroleum Lubricating Oil and Grease Manufacturing
Pharmaceutical and Medicine Manufacturing
Plastics Material and Resin Manufacturing
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Textiles, apparel, and leather manufacturing
Wholesale and Retail Trade

Pharmacology and Biochemistry of N-Octadecanol:

Bionecessity:
N-Octadecanol is found naturally in various mammalian tissues.
N-Octadecanol is used in the biosynthesis of lipids and other naturally occurring cellular constituents and enters metabolic pathways for energy production.

Action Mechanism of N-Octadecanol:
Ethanol, 1-propanol, 1-butanol, 1-pentanol and 1-octanol had essentially the same effects on the mitochondrial ultrastructure: a mixed population of small and enlarged mitochondria with poorly developed cristae.
1-dodecanol induced ultrastructural changes of mitochondria of two distinct types: a mixed population of small and enlarged mitochondria with poorly developed cristae in some hepatocytes and remarkably enlarged mitochondria with well-developed cristate in others; and N-Octadecanol induced remarkably enlarged mitochondria in all hepatocytes.

The reactivity of the fatty alcohols with cetrimide decreased with increasing chain length although branching on the tetradecanol and hexadecanol resulted in a higher reactivity.
Adding N-Octadecanol to 1-hexadecanol resulted in an increased reactivity rising to a maximum for mixtures containing 20-40% w/w N-Octadecanol.

Peak inhibition was recorded with saturated primary alcohols (64 microM) varying in chain length from 16 to 19 carbon atoms.
The unsaturated alcohols (oleyl, linoleyl, and linolenyl) and the secondary alcohol (pentadecan-2-ol) were considerably less effective growth inhibitors.
Stearic and palmitic acids were also ineffective.

After incubation of stationary phase Leishmania donovani with [1-14C]octadecanol, about 70% of the precursor was taken up within 3 hr.
Wax esters and acyl moieties of glycerolipids contained most of the 14C-activity from 3 to 6 hr, because octadecanol was partly oxidized to stearate.

Ether moieties were only weakly labeled.
After 40 hr, 1-0-alkyl and 1-0-alk-1'-enyl diacylglycerols as well as 1-0-alkyl and 1-0-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamines contained nearly all of the radioactivity.
Most of the label in the neutral ether lipids was located in the alkyl ether side chain, whereas, in the phosphatidylethanolamine fraction, most of the label was found in the alkenyl ether side chain.

Human Metabolite Information of N-Octadecanol:

Tissue Locations:
Adipose Tissue
Bladder
Brain
Epidermis
Eye Lens
Fibroblasts
Intestine
Kidney
Liver
Neuron
Ovary
Pancreas
Placenta
Platelet
Prostate
Skeletal Muscle
Spleen
Testis
Thyroid Gland

Cellular Locations:
Extracellular
Membrane

Handling and Storage of N-Octadecanol:

Safe Storage:
Separated from strong oxidants and strong acids.

First Aid Measures of N-Octadecanol:

Eye First Aid:
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Ingestion First Aid:
Rinse mouth.

Fire Fighting:
In case of fire in the surroundings, use appropriate extinguishing media.

Fire Fighting Procedures:
To fight fire use foam, carbon dioxide, dry chemical.

Accidental Release Measures of N-Octadecanol:

Spillage Disposal:
Sweep spilled substance into covered containers.
Carefully collect remainder.
Then store and dispose of according to local regulations.

Cleanup Methods:
Sweep spilled substance into containers.
Carefully collect remainder, then remove to safe place.

Disposal Methods of N-Octadecanol:
The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination.
Recycle any unused portion of the material for N-Octadecanol approved use or return N-Octadecanol to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
N-Octadecanol's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Identifiers of N-Octadecanol:
CAS Number: 112-92-5
ChEBI: CHEBI:32154
ChEMBL: ChEMBL24640
ChemSpider: 7928
ECHA InfoCard: 100.003.652
PubChem CID: 8221
UNII: 2KR89I4H1Y
CompTox Dashboard (EPA): DTXSID8026935
InChI: InChI=1S/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H3
Key: GLDOVTGHNKAZLK-UHFFFAOYSA-N
InChI=1/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H3
Key: GLDOVTGHNKAZLK-UHFFFAOYAZ
SMILES: OCCCCCCCCCCCCCCCCCC

CAS number: 112-92-5
EC number: 204-017-6
Hill Formula: C₁₈H₃₈O
Molar Mass: 270.49 g/mol
HS Code: 2905 17 00

Properties of N-Octadecanol:
Chemical formula: C18H38O
Molar mass: 270.49 g/mol
Appearance: White solid
Density: 0.812 g/cm3
Melting point: 59.4 to 59.8 °C (138.9 to 139.6 °F; 332.5 to 332.9 K)
Boiling point: 210 °C (410 °F; 483 K) at 15 mmHg (2.0 kPa)
Solubility in water: 1.1×10−3 mg/L

Boiling point: 330 - 360 °C
Density: 0.805 - 0.815 g/cm3 (60 °C)
Flash point: 195 °C
Ignition temperature: 230 °C DIN 51794
Melting Point: 55 - 60 °C
Vapor pressure: Bulk density: 300 kg/m3

Molecular Weight: 270.5 g/mol
XLogP3: 8.4
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 16
Exact Mass: 270.292265831 g/mol
Monoisotopic Mass: 270.292265831 g/mol
Topological Polar Surface Area: 20.2Å²
Heavy Atom Count: 19
Complexity: 145
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of N-Octadecanol:
Assay (GC, area%): ≥ 96.0 % (a/a)
Melting range (lower value): ≥ 56 °C
Melting range (upper value): ≤ 59 °C
Identity (IR): passes test

Acid Value (mg KOH/g): 0.1 Max
Saponification Value (mg KOH/g): 0.5 Max
Iodine Value (% I2absorbed): 0.3 Max
Hydroxyl Value (mgKOH/g): 200-210
Hydrocarbon (%): 0.50 max
Color (APHA): 10 Max
Moisture Content (%): 0.2 Max
Fatty Alcohol Content (%): 99 min

Composition (%):
≤ C16: 2 Max
C18: 98 min
≥ C20: 2 Max

Product Form: Liquid
Packaging: Drum; ISO; Bulk

Names of N-Octadecanol:

Regulatory process names:
1-Octadecanol
Octadecan-1-ol
octadecan-1-ol
Stearyl alcohol

IUPAC names:
1-Octadecanol
1-Octadecanol
Alcohol C18
OCTADECAN-1-OL
Octadecan-1-ol
octadecan-1-ol
Octadecan-1-ol
octadecan-1-ol
Octadecanol
Octadecanol
STEARYL ALCOHOL
Stearyl alcohol
stearyl alcohol
Stearyl Alcohol
Stearyl alcohol

Preferred IUPAC name:
Octadecan-1-ol

Trade names:
1-Octadecanol
Stearyl alcohol
Octadecanol
Octadecyl alcohol
N-Octadecanol
Alfol 18
CO-1897
ECOROL 18/98
ECOROL 18/98 F
ECOROL 18/98 P
ECOROL 18/99 P
ECOROL 28
Fatty alcohol 1218
Ginol 1618
Ginol 18
Kalcol
Leunapol-FA 18
MASCOL 1898
MASCOL 1898P
MASCOL 68/30 (70% C18)
MASCOL 68/50 (50% C18)
Nacol 18
Nafol 1218
Nafol 1618
Rofanol 50/55 V
Rofanol 60/65 V
Rofanol 70/75 V
Rofanol 80/85 V
Stearyl Alcohol
TA-1618
MASCOL 1898

Other names:
1-Octadecanol
Octadecan-1-ol

Other identifiers:
112-92-5
193766-48-2
8014-37-7
8032-19-7
8032-21-1
8034-90-0

Synonyms of N-Octadecanol:
Stearyl alcohol
Octadecan-1-ol
1-OCTADECANOL
Octadecanol
112-92-5
1-Hydroxyoctadecane
Octadecyl alcohol
n-Octadecanol
n-1-Octadecanol
Stearol
n-Octadecyl alcohol
Stearic alcohol
Atalco S
Alfol 18
Steraffine
Alcohol stearylicus
Polaax
Stenol
Crodacol-S
Siponol S
Siponol SC
Aldol 62
Lanol S
Sipol S
Adol 68
Decyl octyl alcohol
Cachalot S-43
Lorol 28
1-0ctadecanol
Dytol E-46
Stearylalkohol
Usp xiii stearyl alcohol
Octadecylalkohol
C18 alcohol
Rita SA
Lanette 18
Hainol 18SS
Alcohol(C18)
Custom stearyl
CO-1895
Ultrapure s
Oristar sa
Lipocol s-deo
Lipocol S
Stearyl alcohol s
Crodacol s95
Octadecanol, 1-
Stearyl alcohol pc
Alfol 18 alcohol
Aec stearyl alcohol
Crodacol s-95
Kalcohl 80
Nacol 18do alcohol
Conol 30F
Nikkol stearyl alcohol
CCRIS 3960
Rofamol
Sabonal c 18 95
CO-1897
Nacol 18-94 alcohol
Nacol 18-98 alcohol
Nacol 18-99 alcohol
Conol 1675
HSDB 1082
Octadecanol NF
Crodacol S
NSC 5379
NSC-5379
1-stearyl alcohol
EINECS 204-017-6
UNII-2KR89I4H1Y
BRN 1362907
2KR89I4H1Y
DTXSID8026935
CHEBI:32154
Kalcohl 8098
OCTADECENOL-
AI3-01330
Adol 62
C18H38O
NSC5379
CO 1895F
MFCD00002823
Stearyl alcohol [JAN:NF]
Stearyl alcohol [USAN:JAN]
STEARYL ALCOHOL 98/F
STEARYL ALCOHOL 98/P
DTXCID306935
N-OCTADECYL-D37 ALCOHOL
EC 204-017-6
4-01-00-01888 (Beilstein Handbook Reference)
EINECS 272-778-1
CACHALOT S-56 STEARYL ALCOHOL
68911-61-5
NCGC00159369-02
NCGC00159369-04
STEARYL ALCOHOL (II)
STEARYL ALCOHOL [II]
STEARYL ALCOHOL (MART.)
STEARYL ALCOHOL [MART.]
STEARYL ALCOHOL (USP-RS)
STEARYL ALCOHOL [USP-RS]
STEARYL ALCOHOL (EP MONOGRAPH)
STEARYL ALCOHOL [EP MONOGRAPH]
CAS-112-92-5
stearylalcohol
Octanodecanol
Stearal
-n octadecanol
Alcool starylique
n-octadecylalcohol
Varonic BG
1-hidroxioctadecane
Crodacol S70
Crodacol S95NF
Stearyl alcohol NF
alcohol n-Octadecil
Lanette 18DEO
stearyl alcohol pure
Aec cetearyl alcohol
Cachalot S 43
Cachalot S-56
Crodacol S 70
Crodacol S 95
Laurex 18
Octadecan- 1- ol
Philcohol 1800
Stearyl alcohol USP
Lanette 18 DEO
Alfol 18NF
Conol 30SS
Crodacol 1618
Conol 30S
Lorol C18
86369-69-9
Crodacol S 95 NF
Kalchol 8098
Kalcohl 8099
Alfol 1618 alcohol
Adol 64
Alcohol cetylstearylicus
Alfol 1618e alcohol
Hyfatol 18-95
Hyfatol 18-98
Kalcol 8098
Lorol C 18
Speziol C 18 Pharma
Alfol 1618cg alcohol
1-Octadecanol, 95%
SSD AF (Salt/Mix)
Nacol 18-98
VLTN 6
Ceteareth-20 (Salt/Mix)
SCHEMBL23810
OCTADECANOL [WHO-DD]
STEARYL ALCOHOL [MI]
CHEMBL24640
Stearyl alcohol (JP17/NF)
STEARYL ALCOHOL [JAN]
STEARYL ALCOHOL [HSDB]
STEARYL ALCOHOL [INCI]
WLN: Q18
STEARYL ALCOHOL [VANDF]
SCHEMBL10409854
Stearyl alcohol; octadecan-1-ol
STEARYL ALCOHOL [WHO-DD]
CS-D1671
HY-Y1809
Tox21_111610
LMFA05000085
STL453659
1-Octadecanol, technical grade, 80%
AKOS009031494
Tox21_111610_1
1-Octadecanol, ReagentPlus(R), 99%
CO 1895
CO 1897
CO 1898
Octadecan-1-ol (Langkettige Alkohole)
NCGC00159369-03
LS-97715
SY011369
1-Octadecanol, puriss., >=99.0% (GC)
FT-0761208
O0006
1-Octadecanol, Selectophore(TM), >=99.5%
EN300-19954
1-Octadecanol, Vetec(TM) reagent grade, 94%
D01924
A802702
L000755
Q632384
SR-01000944718
J-002873
SR-01000944718-1
Z104476204
Stearyl alcohol, European Pharmacopoeia (EP) Reference Standard
2DEF44B7-B367-4188-89E4-531379568C74
Stearyl alcohol, United States Pharmacopeia (USP) Reference Standard
Stearyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material
InChI=1/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H
Octadecan-1-ol [Wiki]
112-92-5 [RN]
1362907 [Beilstein]
1-Octadecanol [ACD/Index Name] [ACD/IUPAC Name]
1-Octadecanol [German] [ACD/Index Name] [ACD/IUPAC Name]
1-Octadécanol [French] [ACD/IUPAC Name]
204-017-6 [EINECS]
2KR89I4H1Y
MFCD00002823 [MDL number]
octadecyl alcohol
RG2010000
Stearyl alcohol [JAN] [JP15] [NF] [USAN]
stenol
steryl alcohol
Octadecanol NF [NF]
Stearal
1-hydroxyoctadecane
1-Octacosanol [ACD/Index Name] [ACD/IUPAC Name] [Wiki]
1-Octadecan-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-d37-ol(9CI)
1-OCTADECANOL-1,1-D2
1-Stearyl alcohol
2-(1-adamantyl)-2-amino-acetic acid
2-(adamantan-1-yl)-2-aminoacetic acid
204259-62-1 [RN]
267-008-6 [EINECS]
272-778-1 [EINECS]
557-61-9 [RN]
86369-69-9 [RN]
Adol 62
Atalco S
Cachalot S-56
Cetostearyl alcohol
Conol 1675
Conol 30F
Crodacol S
Crodacol S70
Crodacol S95NF
Crodacol-S
Decyl octyl alcohol
Kalcohl 80
Kalcohl 8098
Lanette 18 DEO
Lanol S
Lorol C18
n-1-octadecanol
n-octadecanol
N-OCTADECYL ALCOHOL
Octadecanol
Octadecanol, 1-
Octadecylalkohol
Octanodecanol
Octodecyl alcohol
Philcohol 1800
Polaax
Q13 [WLN]
Rita SA
Rofamol
Sipol S
Siponol S
Siponol SC
SSD AF
Stearic alcohol
Stearol
Stearyl alcohol NF
Stearyl alcohol USP
Stearylalkohol
Steraffine
UNII:2KR89I4H1Y
UNII-2DMT128M1S
UNII-2KR89I4H1Y
UNII-B1K89384RJ
Varonic BG

N-Octadecylamine, also known as octadecylamine or stearylamine, is a long-chain primary amine with the chemical formula C18H37NH2.
N-Octadecylamine consists of an 18-carbon alkyl chain (octadecyl group) bonded to an amino group (amine).
N-Octadecylamine is classified as a fatty amine due to its long hydrophobic hydrocarbon tail.
N-Octadecylamine is used in various industrial applications, including as an emulsifier, corrosion inhibitor, and as a surfactant in the production of chemicals and materials.
N-Octadecylamine has a wide range of applications, particularly in the manufacture of products like detergents, fabric softeners, and pharmaceuticals.

CAS Number: 124-30-1
EC Number: 204-695-9

APPLICATIONS

N-Octadecylamine is commonly used as an emulsifying agent in the production of emulsions and suspensions.
N-Octadecylamine finds application in the formulation of personal care products such as lotions and creams.
N-Octadecylamine is used as a corrosion inhibitor in metalworking and industrial processes.

N-Octadecylamine can act as a wetting agent in the preparation of paints and coatings.
N-Octadecylamine is utilized in the manufacture of cationic surfactants.

N-Octadecylamine is employed in the synthesis of quaternary ammonium compounds.
N-Octadecylamine plays a role in the production of quaternary ammonium salts, which are used as disinfectants and fabric softeners.
N-Octadecylamine serves as an antistatic agent for plastics and textiles.
N-Octadecylamine is used in the production of antifoaming agents.

N-Octadecylamine is added to lubricants to improve their performance.
N-Octadecylamine is a crucial component in the production of adhesives and sealants.
N-Octadecylamine is used in the manufacture of flotation agents for mineral processing.

N-Octadecylamine can be found in the production of specialty chemicals.
N-Octadecylamine is used as a stabilizing agent in the formulation of dispersions.
N-Octadecylamine plays a role in the production of inkjet ink formulations.
In the pharmaceutical industry, it is utilized in the synthesis of various drugs.
N-Octadecylamine can be added to pesticide formulations to improve their properties.

N-Octadecylamine is used as a dispersing agent for pigments and dyes in the printing industry.
In the textile industry, it assists in the dyeing and finishing processes.
N-Octadecylamine is employed in the formulation of leather and textile auxiliaries.
N-Octadecylamine can be found in detergents and cleaning products.
N-Octadecylamine serves as a processing aid in the production of rubber and plastics.
N-Octadecylamine is used in the preparation of flotation reagents in the mining industry.

N-Octadecylamine plays a role in the manufacturing of various industrial chemicals.
N-Octadecylamine is a versatile chemical with applications in a wide range of industries, thanks to its emulsifying, stabilizing, and surface-active properties.

N-Octadecylamine is used in the production of asphalt additives to improve their performance in road construction.
N-Octadecylamine can be found in the formulation of release agents for mold release in manufacturing processes.
N-Octadecylamine is utilized in the synthesis of corrosion-resistant coatings for metals.
N-Octadecylamine is added to paper coatings to enhance printability and smoothness.

In the field of biotechnology, it is used in the preparation of lipid-based nanoparticles for drug delivery.
N-Octadecylamine is an essential ingredient in the formulation of textile softeners.
N-Octadecylamine is employed in the manufacture of water treatment chemicals for various industrial processes.

N-Octadecylamine is used as an antifoaming agent in the food and beverage industry.
N-Octadecylamine can be found in the production of photovoltaic solar cells and in the electronics industry.
N-Octadecylamine is added to wood preservatives to protect against decay and insects.
N-Octadecylamine is used in the preparation of surface-modifying agents for nanoparticles.
N-Octadecylamine can be found in the formulation of liquid detergents and fabric conditioners.

N-Octadecylamine serves as a leveling agent in the coating industry to improve the smoothness and appearance of coatings.
N-Octadecylamine is employed in the formulation of adhesion promoters for various substrates.
N-Octadecylamine can be added to ink formulations for offset printing.

N-Octadecylamine is utilized in the production of drilling fluids for the oil and gas industry.
N-Octadecylamine is used as a dispersant for pigments in the ceramics industry.
N-Octadecylamine plays a role in the formulation of release coatings for pressure-sensitive adhesive tapes.
N-Octadecylamine is utilized in the preparation of lubricant additives.

N-Octadecylamine can be employed in the synthesis of specialty chemicals used in the automotive industry.
N-Octadecylamine is added to rubber compounds to enhance their processing characteristics.
N-Octadecylamine can be found in the production of fabric treatments for water and stain resistance.

N-Octadecylamine is used as a phase-transfer catalyst in organic synthesis.
N-Octadecylamine finds applications in the preparation of polymer additives.
N-Octadecylamine is used as a stabilizing agent in the formulation of colloidal suspensions and nanoparticles in nanotechnology.

N-Octadecylamine is utilized as a corrosion inhibitor in the oil and gas industry to protect pipelines and equipment from rust and deterioration.
N-Octadecylamine is added to drilling fluids to enhance their lubricating properties and reduce friction during drilling operations.

N-Octadecylamine is used in the production of flotation agents for the separation of minerals in the mining industry.
N-Octadecylamine is found in the formulation of inkjet printer inks to improve ink stability and adhesion to paper.
N-Octadecylamine serves as a processing aid in the manufacture of rubber and plastic products, helping to improve their flow and processing.
In the agrochemical industry, it can be used in pesticide formulations to improve their spreading and adhesion on plant surfaces.

N-Octadecylamine is employed in the preparation of specialty coatings for the automotive and aerospace industries to enhance the durability and appearance of painted surfaces.
N-Octadecylamine can be found in the formulation of wood finishes and varnishes to provide protection and a smooth finish.
N-Octadecylamine is used in the development of surfactants for use in the petroleum industry to enhance oil recovery from reservoirs.

N-Octadecylamine plays a role in the production of surfactants and emulsifiers for use in the food and cosmetic industries.
N-Octadecylamine is used in the creation of surfactants for use in textile wet processing, improving the penetration of dyes and finishing agents.
N-Octadecylamine can be found in the formulation of lubricants for machinery, offering superior lubricating and anti-wear properties.

N-Octadecylamine is employed in the preparation of concrete admixtures to improve the workability and durability of concrete.
N-Octadecylamine is used in the synthesis of specialty chemicals for the manufacturing of high-performance plastics and polymers.

N-Octadecylamine can be added to water-based paints and coatings to improve their dispersion of pigments and fillers.
N-Octadecylamine serves as a leveling agent in the formulation of epoxy and polyurethane coatings to enhance surface smoothness.

N-Octadecylamine is utilized in the development of adhesives and sealants to enhance bonding strength and durability.
N-Octadecylamine can be found in the formulation of inks for flexographic and gravure printing to improve print quality and adhesion to various substrates.

N-Octadecylamine is employed in the production of concrete curing compounds for construction applications.
N-Octadecylamine plays a role in the formulation of wax emulsions used for various applications, including surface protection and release agents.
N-Octadecylamine can be found in the production of asphalt additives for improved pavement performance and durability.

N-Octadecylamine is used as a processing aid in the manufacturing of plastic films and sheets.
N-Octadecylamine is employed in the synthesis of biocides and antimicrobial agents for various applications, including water treatment.
N-Octadecylamine can be added to industrial cleaning products to enhance their cleaning efficiency and emulsifying properties.

N-Octadecylamine is used in the development of additives for the production of synthetic rubber products with improved properties.
N-Octadecylamine is used in the production of adhesion promoters for plastic films and packaging materials.
N-Octadecylamine can be found in the formulation of inkjet printer inks for high-resolution printing on various substrates.

N-Octadecylamine is employed in the development of release agents for the manufacturing of molded rubber and plastic products.
N-Octadecylamine is used in the preparation of asphalt shingle coatings for roofing applications.

N-Octadecylamine serves as a critical ingredient in the formulation of fabric softeners and laundry detergents.
N-Octadecylamine is utilized in the creation of concrete sealers for surface protection and moisture resistance.
N-Octadecylamine can be added to car care products like wax and polish for paint protection and shine.

N-Octadecylamine plays a role in the production of anti-fog coatings for eyeglasses and camera lenses.
N-Octadecylamine is used in the formulation of surfactants for the production of foaming agents in firefighting and extinguishing applications.
N-Octadecylamine is employed in the synthesis of conditioners for leather and footwear.

N-Octadecylamine can be found in the formulation of lubricants for chains and bearings in machinery and equipment.
N-Octadecylamine serves as an anti-blocking agent in the manufacture of plastic films and packaging materials.

N-Octadecylamine is used in the development of inkjet receptor coatings for photo papers and specialty printing media.
N-Octadecylamine is added to paint strippers and removers to enhance their effectiveness in removing coatings and paint layers.

N-Octadecylamine can be employed in the production of air fresheners and odor control products.
N-Octadecylamine is used as a processing aid in the production of PVC compounds and vinyl products.

N-Octadecylamine plays a role in the formulation of emollients for skin and personal care products.
N-Octadecylamine is utilized in the development of release coatings for adhesive labels and tapes.
N-Octadecylamine can be found in the formulation of anti-blocking agents for plastic films and sheets.
N-Octadecylamine is used in the creation of surfactants for textile sizing and finishing processes.

N-Octadecylamine is employed in the production of release agents for baking pans and molds.
N-Octadecylamine can be added to asphalt sealers for driveway and pavement maintenance.
N-Octadecylamine is used in the synthesis of lubricant additives for engine oils and automotive fluids.

N-Octadecylamine plays a role in the formulation of polishes and protectants for household and automotive surfaces.
N-Octadecylamine is used as a processing aid in the production of plastic and rubber compounds for various applications.

DESCRIPTION

N-Octadecylamine, also known as octadecylamine or stearylamine, is a long-chain primary amine with the chemical formula C18H37NH2.
N-Octadecylamine consists of an 18-carbon alkyl chain (octadecyl group) bonded to an amino group (amine).
N-Octadecylamine is classified as a fatty amine due to its long hydrophobic hydrocarbon tail.
N-Octadecylamine is used in various industrial applications, including as an emulsifier, corrosion inhibitor, and as a surfactant in the production of chemicals and materials.
N-Octadecylamine has a wide range of applications, particularly in the manufacture of products like detergents, fabric softeners, and pharmaceuticals.

N-Octadecylamine is a long-chain organic compound.
N-Octadecylamine is also known as octadecylamine or stearylamine.
N-Octadecylamine has 18 carbon atoms in its hydrocarbon chain.

N-Octadecylamine has a primary amine functional group.
N-Octadecylamine is a colorless to pale yellowish liquid at room temperature.
N-Octadecylamine is sparingly soluble in water.

N-Octadecylamine is highly soluble in organic solvents.
N-Octadecylamine is often used as an emulsifying agent.
N-Octadecylamine is commonly employed as a corrosion inhibitor.

N-Octadecylamine is a surfactant with amphiphilic properties.
N-Octadecylamine group is the polar part of the molecule.
The hydrocarbon tail is hydrophobic and nonpolar.
N-Octadecylamine is derived from stearic acid.

N-Octadecylamine is widely used in the chemical industry.
N-Octadecylamine is utilized in the production of detergents.
N-Octadecylamine is also found in fabric softeners.
N-Octadecylamine is an essential ingredient in pharmaceuticals.
N-Octadecylamine is used in the synthesis of various chemicals.

Its long hydrocarbon chain imparts lubricating properties.
N-Octadecylamine is an effective antistatic agent.
N-Octadecylamine can act as a dispersing agent for pigments and dyes.

N-Octadecylamine is known for its low toxicity.
N-Octadecylamine may be present in cleaning products.
N-Octadecylamine helps improve the stability of emulsions and suspensions.
Its CAS number is 124-30-1, and its EC number is 204-695-9.

PROPERTIES

Chemical Formula: C18H37NH2
Molecular Weight: Approximately 283.5 g/mol
Physical State: It is typically a colorless to pale yellowish liquid at room temperature.
Odor: It may have a slight amine-like odor.
Solubility: N-Octadecylamine is sparingly soluble in water but highly soluble in organic solvents, such as alcohols and hydrocarbons.
Melting Point: The melting point of pure N-octadecylamine is around 35-38°C (95-100°F).
Boiling Point: It has a relatively high boiling point, typically in the range of 300-315°C (572-599°F).
Density: Its density varies, but it is generally less dense than water, so it will float on water.
Flash Point: N-Octadecylamine may have a flash point when exposed to open flame or sparks, but the specific value may vary depending on impurities.
Viscosity: It exhibits relatively low viscosity.
Surface Tension: As a surfactant, it can lower the surface tension of liquids.
pH: The pH of a pure N-octadecylamine solution is typically alkaline.
Hygroscopicity: It may absorb moisture from the atmosphere, making it necessary to store it in airtight containers.
Chemical Nature: It is a primary aliphatic amine with a long hydrophobic tail.
Polarity: The amine group is polar, while the long hydrocarbon chain is nonpolar.
Flammability: Like many organic compounds, N-octadecylamine can be flammable if exposed to open flame or high heat.
Toxicity: N-Octadecylamine is generally considered to have low toxicity, but safety precautions should be taken when handling it.
Reactivity: It can react with acids, acids anhydrides, and isocyanates.
Stability: It is stable under normal storage conditions.

FIRST AID

Inhalation:

If inhaled, move the affected person to an area with fresh air.
If breathing is difficult, administer artificial respiration.
Seek immediate medical attention.

Skin Contact:

Remove contaminated clothing and shoes.
Wash the affected skin area gently with plenty of water for at least 15 minutes.
Use soap or a mild detergent to help remove the substance from the skin.
Seek medical attention if skin irritation or chemical burns occur.

Eye Contact:

Flush the eyes with gentle, continuous, and flowing water for at least 15 minutes, lifting the upper and lower eyelids occasionally to ensure thorough rinsing.
Seek immediate medical attention and continue rinsing the eyes while awaiting medical help.

Ingestion:

If swallowed, do NOT induce vomiting unless directed by medical personnel.
Rinse the mouth with water if the person is conscious and able to swallow.
Seek immediate medical attention. Provide the medical personnel with the details of the ingested substance.

HANDLING AND STORAGE

Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles or face shield, and a lab coat or protective clothing.
Use chemical-resistant apron or clothing to minimize skin contact.
Wear respiratory protection if there is a risk of inhaling vapors or aerosols.

Ventilation:
Use local exhaust ventilation to control airborne concentrations, especially in enclosed spaces.
Ensure adequate general ventilation in the work area to disperse any fumes or vapors.

Avoidance of Contact:
Minimize skin and eye contact.
Avoid all unnecessary exposure.
Do not eat, drink, or smoke while handling the chemical.

Handling Precautions:
Use non-sparking tools and equipment to reduce the risk of ignition.
Use explosion-proof equipment in areas where there is a potential for flammable vapors or dust.
Handle N-octadecylamine in a well-ventilated chemical fume hood if possible.
Avoid contact with incompatible materials and substances.
Consult safety data sheets for guidance.

Spills and Leaks:
In the event of a spill, contain the material and prevent it from spreading.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect in a suitable container for disposal.
Clean up spills following established procedures and wearing appropriate protective equipment.
Dispose of contaminated materials in accordance with local, state, and federal regulations.

Storage Containers:
Store N-octadecylamine in containers made of materials compatible with the chemical (e.g., glass, stainless steel).
Ensure that storage containers are tightly sealed to prevent evaporation and contamination.

Storage:

Storage Conditions:
Store N-octadecylamine in a cool, dry, and well-ventilated area.
Keep containers tightly closed to prevent exposure to air and moisture.
Avoid exposure to extreme temperatures, direct sunlight, and ignition sources.
Do not store near incompatible materials, such as strong acids or strong oxidizing agents.

Storage Temperature:
Maintain storage temperatures in the recommended range specified in the safety data sheet or manufacturer's guidelines.

Segregation:
Store N-octadecylamine away from food, beverages, and animal feed.
Separate from incompatible chemicals, and use appropriate labeling and segregation to avoid cross-contamination.

Secondary Containment:
Use secondary containment measures, such as spill containment pallets, for larger quantities to prevent leaks or spills from spreading.

Safety Data Sheets (SDS):
Keep safety data sheets (SDS) readily accessible for reference by personnel in case of emergency or accidental exposure.

SYNONYMS

Stearylamine
Octadecylamine
1-Octadecanamine
Octadecylamine
N-Stearylamine
Octadecylamine, stearylamine
Octadecylamine, arachidic amine
Octadecylamine, n-octadecylamine
Arachidic amine
Octadecylamine, n- (French)
1-Octadecylamine
Adogen 282 (a trade name)
Arachidylamine
n-C18H37NH2
Amine C18
Alamine 336 (a trade name)
Alkamine 336
Armeen 18D (a trade name)
Stearamine
Adogen 381 (a trade name)
Stearylamine
1-Octadecanamine
Arachidic amine
Octadecylamine
Stearamine
Octadecyl amine
N-Octadecylamine
Stearyl amine
Arachidylamine
Octadecylamine, N-
Adogen 282
Alamine 336
Alkamine 336
Armeen 18D
Octadecylamine, n- (French)
Amine C18
Adogen 381
Armeen 18-D
Armac C
1-Stearoylamine
N-Heptadecylamine
Stearamin
Octadecylamine, N- (German)
Alamine 336K
Armeen 18D-O

1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone CAS NO: 2687-94-7

1-Octyl-2-Pyrrolidinone; N-Octyl-2-pyrrolidone; N-Octylpyrrolidinone; 1-Octylpyrrolidin-2-on; N-Octylpyrrolidone; cas no: 2687-94-7

Tensioactifs, oxyde de propylène, oxyde d'éthylène, polymères séquencés, Alkylphénols éthoxylés, Alcools éthoxylés, Decyl glucoside, Cetyl alcohol, les glutamates, Lauryl glucoside, Coco glucoside

Nonanedioic acid is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH).
Nonanedioic acid is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners
Nonanedioic acid is an ingredient with antibacterial, skin cell regulating, anti-inflammatory and skin-lightening magic properties.

CAS Number: 123-99-9
EC Number: 204-669-1
Molecular formula: C9H16O4
Molar mass: 188.22 g/mol

1,7-dicarboxyheptane, 1,7-Heptanedicarboxylic acid, 1,9-nonanedioic acid, acide azélaïque, acidum azelaicum, anchoic acid, Azelaic acid, AZELAIC ACID, azelaic acid, Azelainsäure Deutsch, lepargylic acid, n-nonanedioic acid, Nonandisäure Deutsch, Nonanedioic acid, 1,7-Heptanedicarboxylic acid, 1101094 [Beilstein], 123-99-9 [RN], 204-669-1 [EINECS], Acide azélaïque [French] [ACD/IUPAC Name], acide nonanedioïque [French], Acido azelaico [Spanish], anchoic acid, Azalaic Acid, Azelaate [ACD/IUPAC Name], Azelaic acid [ACD/IUPAC Name] [USAN] [Wiki], Azelainic acid, Azelainsäure [German] [ACD/IUPAC Name], Azelex [Trade name], Finaceae [Trade name], lepargylic acid, MFCD00004432 [MDL number], Nonandisäure [German], Nonanedioic acid [ACD/Index Name], Skinoren [Trade name], 1,7-dicarboxyheptane, 1,9-NONANEDIOIC ACID, 119176-67-9 [RN], acide azelaique [French], Acido azelaico [Spanish], Acidum acelaicum, Acidum azelaicum [Latin], AHI, AZ1, Azelaic acid,, azelaicacid, Azelainsäure [ACD/IUPAC Name], Azelate, DB00548, Emery's L-110, Finacea [Wiki], Heptanedicarboxylic acid, n-nonanedioic acid, Nonandisäure, Nonanedioate, Nonanedioic-D14 Acid, Nonanedionic acid, Skinorem, Water-soluble azelaic acid, Zumilin, азелаиновая кислота, حمض أزيلائيك, 壬二酸, azelaic acid, NONANEDIOIC ACID, 123-99-9, Finacea, Anchoic acid, Azelex, 1,7-Heptanedicarboxylic acid, Lepargylic acid, Skinoren, 1,9-Nonanedioic acid, Heptanedicarboxylic acid, n-Nonanedioic acid, Emerox 1110, Emerox 1144, acide azelaique, Finevin, Azelainic acid, acidum azelaicum, azelate, Polyazelaic anhydride, Skinorem, 1,7-Dicarboxyheptane, Azelaic acid, technical grade, Emery's L-110, azelaate, Poly(azelaic anhydride), ZK 62498, ZK-62498, UNII-F2VW3D43YT, NSC 19493, Azelaic acid 99%, Azelaic acid, 98%, CHEBI:48131, MFCD00004432, F2VW3D43YT, MLS000069659, 26776-28-3, NSC19493, NSC-19493, NCGC00014993-07, SMR000059164, Acido azelaico, Azalaic Acid, DSSTox_CID_1640, Acide azelaique [French], Acido azelaico [Spanish], Acidum azelaicum [Latin], DSSTox_RID_76254, DSSTox_GSID_21640, heptane-1,7-dicarboxylic acid, Azelaic acid [USAN:INN], Azelaic polyanhydride, Nonanedioic acid, homopolymer, Azelaic, Azelaic acid polyanhydride, CAS-123-99-9, Finacea (TN), Azelex (TN), SR-01000075671, EINECS 204-669-1, Azelaic acid (USAN/INN), BRN 1101094, Azelaicacidtech, Azelainsaeure, Lepargylate, Nonandisaeure, Anchoate, Nonanedioic acid, sodium salt, n-Nonanedioate, AI3-06299, nonanedionic acid, HSDB 7659, 1tuf, azelaic acid group, 1,9-Nonanedioate, SH-441, AGN-191861, Spectrum_000057, ACMC-1BTAP, Opera_ID_740, Polyazelaic Polyanhydride, 1,7-Heptanedicarboxylate, Spectrum2_000995, Spectrum3_000278, Spectrum4_000401, Spectrum5_001304, C9-120-alpha-polymorph, C9-140-alpha-polymorph, C9-180-alpha-polymorph, C9-220-alpha-polymorph, C9-260-alpha-polymorph, C9-298-alpha-polymorph, Epitope ID:187039, A-9800, EC 204-669-1, Nonanedioic acid homopolymer, Lopac-246379, SCHEMBL3887, CHEMBL1238, Lopac0_000051, BSPBio_001756, KBioGR_000662, KBioSS_000437, Nonanedioic acid Azelaic acid, 4-02-00-02055 (Beilstein Handbook Reference), 1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, 1-azelaoyl-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, 2-azelaoyl-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, nonanedioic acid monoglycoside has functional parent nonanedioic acid, azelaate is conjugate base of nonanedioic acid, azelaate(2−) is conjugate base of nonanedioic acid

Nonanedioic acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products.
Nonanedioic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

Nonanedioic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to Nonanedioic acid inhibitory effect on the synthesis of microbial cellular proteins.
Nonanedioic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers.

Nonanedioic acid also possesses a direct anti-inflammatory effect due to Nonanedioic acid scavenger activity of free oxygen radical.
This drug is used topically to reduce inflammation associated with acne and rosacea.

Nonanedioic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Nonanedioic acid is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin.

Nonanedioic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Nonanedioic acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Nonanedioic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.

Nonanedioic acid is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH).
Nonanedioic acid possesses a variety of biological actions both in vitro and in vivo.

Interest in the biological activity of Nonanedioic acid arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection.
Later, Nonanedioic acid was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro.

Nonanedioic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: Nonanedioic acid possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base cream than other dicarboxylic acids.
Nonanedioic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris.

Nonanedioic acid offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin.
Nonanedioic acid is less expensive than certain other prescription acne preparations, but Nonanedioic acid is much more expensive than nonprescription benzoyl peroxide preparations.
Whether Nonanedioic acid is safe and effective when used in combination with other agents is not known.

Nonanedioic acid is an organic compound with the formula HOOC(CH2)7COOH.
This saturated dicarboxylic acid exists as a white powder.

Nonanedioic acid is found in wheat, rye, and barley.
Nonanedioic acid is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners

Nonanedioic acid has role antibacterial agent.
Nonanedioic acid has role antineoplastic agent.

Nonanedioic acid has role dermatologic drug.
Nonanedioic acid has role plant metabolite.

Nonanedioic acid is a α,ω-dicarboxylic acid.
Nonanedioic acid is conjugate acid of azelaate.
Nonanedioic acid is conjugate acid of azelaate(2−).

Nonanedioic acid is a dicarboxylic acid and is a white crystalline powder available in various purity grades depending on the final application.
The innovative production process achieves Nonanedioic acid with very high purity and low monocarboxylic content, fundamental features for Nonanedioic acid use as an intermediate in polymerization processes, typically as an alternative to sebacic acid and adipic acid.

The physiologic effect of Nonanedioic acid is by means of Decreased Protein Synthesis, and Decreased Sebaceous Gland Activity.

Nonanedioic acid is an ingredient with antibacterial, skin cell regulating, anti-inflammatory and skin-lightening magic properties.
Nonanedioic acid is especially useful for acne-prone or rosacea-prone skin types (in concentration 10% and up)
Nonanedioic acid is a prescription drug in the US but can be freely purchased in the EU in an up to 10% concentration.

Nonanedioic acid is a compound found in wheat, rye and barley that can help treat acne and rosacea because Nonanedioic acid soothes inflammation.
Nonanedioic acid treats sunspots and melasma because Nonanedioic acid blocks the production of abnormal pigmentation

Nonanedioic acid is also a tyrosinase inhibitor, meaning Nonanedioic acid can prevent hyperpigmentation because it interferes with melanin production.
Nonanedioic acid is anti-inflammatory for the acne and Nonanedioic acid is anti-pigment because it blocks tyrosinase.

Nonanedioic acid is a more gentle exfoliant than other alpha hydroxy acids (AHAs), including glycolic, lactic and mandelic acids

Chemically, Nonanedioic acid is a dicarboxylic acid.
Nonanedioic acid works on skin as a gentle leave-on exfoliant which helps unclog pores and refine skin's surface.

Nonanedioic acid also significantly lessens factors in skin that lead to sensitivity and bumps and delivers antioxidant benefits.
Nonanedioic acid can be derived from grains like barley, wheat, and rye, but it’s the lab-engineered form that is typically used in skincare products because of Nonanedioic acid stability and effectiveness.

Much of the research on this ingredient has looked at prescription-only topical products with concentrations between 15% and 20%, but there are incredible benefits to be seen even at lower concentrations.

Nonanedioic acid is a naturally occurring acid found in grains like barley, wheat, and rye.
Today's Nonanedioic acid is synthesized in a lab, though, to ensure Nonanedioic acid is uniform and stable.

Nonanedioic acid is an exfoliant that unclogs pores and also reduces pigmentation and the effects of scarring.
Nonanedioic acid manipulates the most upper layers in the cells which leaves you with a smooth and visibly healthier skin tone.
If you’re looking for a brighter skin tone with visibly improved evenness, skincare including Nonanedioic acid is a great choice.

Nonanedioic acid isn't an incredibly common skin care ingredient, but Nonanedioic acid can be found in some over-the-counter anti-aging and skin brightening products in strengths up to 10%.
For treating acne or rosacea, though, a prescription strength of at least 15% is needed.

Nonanedioic acid is relatively obscure when compared to some of the more trendy and well-known skin care acids like glycolic, lactic, salicylic, and even hyaluronic acid.
But Nonanedioic acid works slightly differently than other skin care acids.

Over-the-counter Nonanedioic acid can help improve minor blackheads, refine the pores, even out skin tone, and brighten the complexion.
Stronger, prescription Nonanedioic acid has even more benefits for the skin.

Topical Nonanedioic acid formulations have been used to address a wide range of physiological maladies including acne, hyperpigmentary dermatoses, hair loss, wrinkling, hyperhidrosis, non-acne inflammatory dermatoses, infectious cutaneous diseases and ichthyosis.
However, the only topical formulations of Nonanedioic acid presently known are dispersions.

Dispersions deliver Nonanedioic acid in an undissolved state.
When applied to the skin, undissolved Nonanedioic acid is not readily absorbed and as a result an excess of Nonanedioic acid must be present to be effective.

The higher the concentration of Nonanedioic acid, the more likely irritation (burning, stinging and redness) to the skin will occur.
What is needed is a completely solubilized topical Nonanedioic acid composition.

Solubilized Nonanedioic acid is much less likely to irritate the skin because Nonanedioic acid in a dissolved state is much more readily absorbed by the need be present in the formulation to be effective thereby lowering the risk of irritation to the skin.
While Nonanedioic acid is somewhat soluble in water, cosmetic oils and alcohols, each of these solvents has serious limitations.

Thus, water only marginally dissolves Nonanedioic acid so that a water and Nonanedioic acid solution would contain a maximum of about .24% by weight (w/w) Nonanedioic acid, not likely enough to be effective.
Nonanedioic acid has little or no solubility in cosmetic oils.

Alcohols are good solvents but are unsatisfactory because large amounts of alcohol e.g., isopropyl alcohol, in a topical composition has the undesirable side effect of drying the skin.
Indeed, some alcohols e.g., ethyl alcohol, render Nonanedioic acid unstable at normal temperatures and atmospheric pressures resulting in a totally ineffective composition

Nonanedioic acid is produced by a yeast (Malassezia fur fur, also known as Pityrosporum ovale) that is part of normal skin flora.
Nonanedioic acid can help in both acne vulgaris and acne rosacea as an antimicrobial, antiinflammatory, and comedolytic.

Nonanedioic acid can also be used for postinflammatory hyperpigmentation.
One study that compared results of European clinical trials showed Nonanedioic acid 20% cream is as effective as tretinoin 0.05%, benzoyl peroxide 5%, and topical erythromycin 2%.
Nonanedioic acid is similar to benzoyl peroxide, but there is less evidence of Nonanedioic acid usefulness.

Dosage:
Recommended dosage is 20% cream for acne vulgaris and 15% gel for acne rosacea, both applied one to two times a day.

Precautions:
Can cause hypopigmentation and some skin irritation but is usually well tolerated.

Topical Nonanedioic acid:
The topical application of Nonanedioic acid appears to be extremely effective in papulopustular rosacea.
Initially, Nonanedioic acid was released in a 20% cream formulation and was shown in this vehicle to be effective in the treatment of mild to moderate rosacea.

A 15% gel formulation of Nonanedioic acid vastly improved the delivery of Nonanedioic acid and has been shown to be superior in head-to-head studies to the 20% Nonanedioic acid cream.
Nonanedioic acid is equally as effective as metronidazole cream or gel.

In a meta-analysis of five double-blind trials involving topical Nonanedioic acid (cream or gel) for the treatment of rosacea compared with placebo or other topical treatments, four of five studies demonstrated significant decreases in mean inflammatory lesion count and erythema severity after treatment with Nonanedioic acid compared with placebo, and Nonanedioic acid was found to be equal to metronidazole in papulopustular rosacea.
However, no significant decrease in the severity of telangiectasia occurred in any treatment group.

Overexpression of cathelicidin peptide LL-37 has been implicated in the pathophysiology of rosacea, and Nonanedioic acid has been found to inhibit the pathological expression of cathelicidin, as well as the hyperactive protease activity that cleaves cathelicidin into LL-37.
A small, prospective, open-label, interventional study was performed to assess the effects of Nonanedioic acid 15% gel on inflammatory lesions of papulopustular rosacea.
Nonanedioic acid use was associated with a significant reduction in inflammatory lesions, and these results persisted beyond the active treatment phase.

Chemical peels:

Bleaching agents:
Hydroquinones are the most commonly used bleaching agents; other products include Nonanedioic acid, aloesin, vitamin C, arbutin, licorice extract, glabridin, mequinol (4-hydroxyanisol), melatonin, niacinamide, paper mulberry, soy, vitamin E, kojic acid, α- and β-hydroxy acids, and retinoids and retinoid combination therapy.

Nonanedioic acid is a prescription medication used to treat mild to moderate acne vulgaris, as well as rosacea.

Nonanedioic acid comes in a gel, lotion, and cream.
Nonanedioic acid is sold under the brand names Azelex, Finacea, and Finevin, as well as generic Nonanedioic acid.

Uses of Nonanedioic acid:
Nonanedioic acid is used in many pharmaceutical preparations as an active ingredient in acne rosacea, due to Nonanedioic acid therapeutic effectiveness.
The vegetable origin of Nonanedioic acid makes it particularly suitable also for other important applications such as the synthesis of complex esters.

Uses in Practice:
Topical Nonanedioic acid is Food and Drug Administration (FDA) approved for mild-moderate inflammatory acne vulgaris under the brand name Azelex as 20% cream.
Nonanedioic acid is also FDA approved for mild-to-moderate papulopustular rosacea under the brand name Finacea as 15% gel and 15% foam.
At this time, Nonanedioic acid is not approved for any other subtype of rosacea.

In clinical studies for Nonanedioic acid gel 15% (Finacea), there was some reduction of erythema noted in patients treated for papulopustular rosacea, but no specific clinical trials were performed to study erythema in rosacea in the absence of papules and pustules.
Nonanedioic acid is also used off-label for the treatment of hyperpigmentation disorders, including melasma, due to Nonanedioic acid inhibition of tyrosinase.

Pharmacokinetics:
Topical Nonanedioic acid has a bioavailability of up to 10% in the epidermis and dermis.
Approximately 4% of Nonanedioic acid cream or gel is absorbed systemically after topical application.

Nonanedioic acid is a saturated dicarboxylic acid (HOOC-(CH2)7-COOH) found in many foods, including animal products and whole grains.
Nonanedioic acid may undergo some beta-oxidation to shorter-chain dicarboxylic acids, but Nonanedioic acid is predominately excreted in its original form in urine.

The half-life of topical Nonanedioic acid is approximately 12 hours, and the patient should apply Nonanedioic acid to the area of concern twice daily.
Favorable results are typically seen within 4 weeks in patients with acne vulgaris and within 12 weeks in patients with papulopustular rosacea.

Uses of Nonanedioic acid for acne:

Nonanedioic acid works by:
Clearing your pores of bacteria that may be causing irritation or breakouts.
Reducing inflammation so acne becomes less visible, less red, and less irritated.
Gently encouraging cell turnover so your skin heals more quickly and scarring is minimized.

Nonanedioic acid can be used in gel, foam, or cream form.

All forms have the same basic instructions for use:
Wash the affected area thoroughly with warm water and pat dry.
Use a cleanser or mild soap to make sure the area is clean.

Wash your hands before applying the medication.
Apply a small amount of medication to the affected area, rub Nonanedioic acid in, and let it dry completely.

Once the medication has dried, you can apply cosmetics.
There’s no need to cover or bandage your skin.
Keep in mind that you should avoid using astringents or “deep-cleansing” cleansers while you use Nonanedioic acid.

Some people will need to apply the medication twice per day, but this will vary according to a doctor’s instructions.

Nonanedioic acid for acne scars:
Some people use azelaic to treat acne scarring in addition to active outbreaks.
Nonanedioic acid encourages cell turnover, which is a way to reduce how severe scarring appears.

Nonanedioic acid also prevents what’s known as melanin synthesis, the ability of your skin to produce pigments that can vary your skin’s tone.

If you’ve tried other topical medications to help with scarring or blemishes that’re slow to heal, Nonanedioic acid might help.
More research is needed to understand who this treatment works best for and how effective Nonanedioic acid can be.

Other uses:
Nonanedioic acid is also used for other skin conditions, such as hyperpigmentation, rosacea, and skin lightening.

Nonanedioic acid for hyperpigmentation:
After a breakout, inflammation can result in hyperpigmentation on some areas of your skin.
Nonanedioic acid stops discolored skin cells from populating.

A pilot study from 2011 showed Nonanedioic acid can treat acne while evening out hyperpigmentation triggered by acne.
Further research on skin of color has also shown that Nonanedioic acid is safe and beneficial for this use.

Nonanedioic acid for skin lightening:
The same property that makes Nonanedioic acid effective for the treatment of inflammatory hyperpigmentation also enables Nonanedioic acid to lighten skin that’s discolored by melanin.

Using Nonanedioic acid for skin lightening in patchy or blotchy areas of your skin due to melanin has been found effective, according to an older study.

Nonanedioic acid for rosacea:
Nonanedioic acid can reduce inflammation, making it an effective treatment for symptoms of rosacea.
Clinical studies demonstrate that Nonanedioic acid gel can continually improve the appearance of swelling and visible blood vessels caused by rosacea.

According to older research, Nonanedioic acid cream may be as effective as benzoyl peroxide and tretinoin (Retin-A) for the treatment of acne.
While Nonanedioic acid results are similar to those of benzoyl peroxide, it’s also more expensive.

Nonanedioic acid also works more gently than alpha hydroxy acid, glycolic acid, and salicylic acid.
While these other acids are strong enough to be used on their own in chemical peels, Nonanedioic acid isn’t.

This means that while Nonanedioic acid is less likely to irritate your skin, Nonanedioic acid also has to be used consistently and given time to take effect.

Takeaway:
Nonanedioic acid is a naturally occurring acid that’s milder than some more popular acids used to treat acne.
While the results of treatment with Nonanedioic acid might not be obvious right away, there is research that points to this ingredient as effective.

Acne, uneven skin tone, rosacea, and inflammatory skin conditions have all been shown to be effectively treated with Nonanedioic acid.
As with any medication, follow the dosing and application directions from your doctor closely.

Face acids, or skin acids, work by exfoliating, or shedding, the top layer of your skin.
Whenever you exfoliate your skin, new skin cells emerge to take the place of the old ones.
The process helps even out your skin tone and makes Nonanedioic acid smoother overall.

Many face acids are available OTC at beauty stores and drugstores.

Popular options include:
Alpha hydroxy acids, such as glycolic, lactic, citric, malic, or tartaric acid
Nonanedioic acid
Kojic acid
Salicylic acid
Vitamin C (in the form of l-ascorbic acid)

Main uses:
Fibres (E.g. Nylon 6,9 - Nylon 5,9 - Nylon 6,69)
Polyester Polyols (Polyurethanes and PUR Hotmelt)
Bioplastics (Polyesters)
Hot Melt Adhesives (Polyamides, Polyester)
Polyamide Hardeners (Epoxy Resins)
Low Temperature Plasticisers (Dioctyl Azelate DOZ)

Nonanedioic acid can also be used directly in other formulations such as:
Electrolytes for Capacitors
Lithium Complex Greases
Metalworking Fluids, Corrosion Inhibitors
Coating - Powder Resins (GMA)
Engine cooling fluids

Applications of Nonanedioic acid:
Nonanedioic acid is a naturally occurring acid found in grains such as barley, wheat, and rye.
Nonanedioic acid has antimicrobial and anti-inflammatory properties, which make Nonanedioic acid effective in the treatment of skin conditions like acne and rosacea.

Nonanedioic acid can prevent future outbreaks and clean bacteria from your pores that causes acne.
Nonanedioic acid is applied to your skin and is available in gel, foam, and cream form.

Azelex and Finacea are two brand names for prescription topical preparations.
They contain 15 percent or more of Nonanedioic acid. Some over-the-counter products contain smaller amounts.

Because Nonanedioic acid takes some time to take effect, Nonanedioic acid by itself isn’t typically a dermatologist’s first choice for treating acne.
Nonanedioic acid also has some side effects, such as skin burning, dryness, and peeling.

The antibacterial, antiphlogistic and keratolytic Nonanedioic acid is used in acne therapy.
Nonanedioic acid is also used for treatment of skin pigmentation including melasma and post-inflammatory hyperpigmentation, particularly in individuals with darker skin types.

Nonanedioic acid has been recommended as an alternative to hydroquinone.
As a tyrosinase inhibitor, Nonanedioic acid reduces synthesis of melanin.

About 4–8% of the topically applied substance is absorbed systemically.
In animal experiments Nonanedioic acid, even in high doses, is not teratogenic.
However, systematic studies on Nonanedioic acid use in humans are lacking.

Recommendation:
During pregnancy, Nonanedioic acid should only be used for strict indications on small skin surfaces, e.g. facial acne, preferably not in the first trimester.

Esters of this dicarboxylic acid find applications in lubrication and plasticizers.
In lubricant industries Nonanedioic acid is used as a thickening agent in lithium complex grease.
With hexamethylenediamine, Nonanedioic acid forms Nylon-6,9, which finds specialized uses as a plastic

Medical:
Nonanedioic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne.
Nonanedioic acid belongs to a class of medication called dicarboxylic acids.

Nonanedioic acid works by killing acne bacteria that infect skin pores.
Nonanedioic acid also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria.

Nonanedioic acid is also used as a topical gel treatment for rosacea, due to Nonanedioic acid ability to reduce inflammation.
Nonanedioic acid clears the bumps and swelling caused by rosacea.
The mechanism of action is thought to be through the inhibition of hyperactive protease activity that converts cathelicidin into the antimicrobial skin peptide LL-37.

Acne treatment:
In patients with moderate acne twice daily over 3 month topical 20% Nonanedioic acid reduced numbers of comedones, papules and pustules.
Along with retinoids Nonanedioic acid is considered to be effective in improving acne-treatment results.

The studies of latter though were admittedly limited.
In comparative review of effects of topical Nonanedioic acid, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid Nonanedioic acid enjoyed more high-quality evidence of effectiveness than the rest.

Whitening agent:
Nonanedioic acid has been used for treatment of skin pigmentation including melasma and postinflammatory hyperpigmentation, particularly in those with darker skin types.
Nonanedioic acid has been recommended as an alternative to hydroquinone.

As a tyrosinase inhibitor, Nonanedioic acid reduces synthesis of melanin.
According to one report of 1988 Nonanedioic acid (in combination with zinc sulfate) in vitro showed to be a potent (90% inhibition) 5α-Reductase inhibitor, similar to the hair loss drugs finasteride and dutasteride.
Middle 80s in vitro research evaluating acid's depigmenting (whitening) capability concluded Nonanedioic acid is effective (cytotoxic to melanocytes) only at high concentrations.

More recent review claimed 20% Nonanedioic acid being more potent than 4% hydroquinon after period of application for three months without latter's adverse effects and even more effective if applied along with tretinoin for the same period of time.

Brand names:
Brand names for Nonanedioic acid include Dermaz 99, Crema Pella Perfetta (micronized Nonanedioic acid, kojic dipalmitate, and liquorice extract), Azepur99, Azetec99, Azaclear (Nonanedioic acid and niacinamide), AzClear Action, Azelex, White Action cream, Finacea, Finevin, Melazepam, Skinoren, Ezanic, Azelac, Azaderm, (Acnegen, Eziderm, Acnicam, Azelexin in Pakistan)

Topical Antibacterial Agents:

Disorders of Pigmentation:
Nonanedioic acid has no depigmenting activity on normal skin, solar freckles, senile freckles, lentigines, pigmented seborrheic keratoses, or nevi.
Nonanedioic acid has some activity against hypermelanosis caused by physical and chemical agents, postinflammatory hyperpigmentation, melasma, lentigo maligna, and lentigo maligna melanoma.
In melasma, treatment for 24 weeks with Nonanedioic acid 20% cream alone showed similar efficacy to treatment for 8 weeks with clobetasol 0.05% cream followed by 16 weeks with Nonanedioic acid 20% cream (90% vs. 96.7% improvement).

Benefits of Nonanedioic acid in Skin Care Products:
Nonanedioic acid products in concentrations of 10% or less aren’t easy to find, as very few brands have discovered Nonanedioic acid powerful skincare benefits, perhaps because it’s just such a tricky ingredient to formulate properly.
If not formulated properly, the texture may be grainy, which could be problematic for skin.

If you’re wondering whether to choose a cosmetic Nonanedioic acid skin care product or a prescription version, research has shown that a 10% concentration can still improve many of the visible imperfections some of us struggle with, from bumps to dull, uneven skin tone and various concerns related to aging.

But, there are some stubborn or advanced skin concerns where it’s best to consider one of the prescription products with Nonanedioic acid.
You and your dermatologist can discuss whether a prescription Nonanedioic acid product is right for you, and how to work Nonanedioic acid into your skincare routine.

The Science Behind Nonanedioic acid Skin Care Products:
Researchers have a theory on how Nonanedioic acid works its skin-improving magic.
What's suspected is that Nonanedioic acid works by inhibiting misbehaving elements on and within skin's uppermost layers.

Left unchecked, these troublemakers lead to persistent, visible skin imperfections (like brown patches and post-blemish marks), dull skin tone, and signs of sensitivities.
Nonanedioic acid seems Nonanedioic acid has a radar-like ability to interrupt or inhibit what's causing skin to act up.
Skin "hears" the message Nonanedioic acid sends and responds favorably, which leads to skin that looks remarkably better, no matter your age, skin type, or concerns.

The ongoing research on Nonanedioic acid led us to formulate our 10% Nonanedioic acid Booster.
The Nonanedioic acid within targets a wide range of skin imperfections and is formulated with 0.5% salicylic acid for a bit of a pore-refining nudge.

The 10% Nonanedioic acid Booster also contains a soothing complex of brightening plant extracts plus skin-restoring adenosine, an energizing ingredients that visibly reduces signs of aging.
Adding the 10% Nonanedioic acid Booster to your routine is easy: Nonanedioic acid can be applied once or twice daily after cleansing, toning, and exfoliating.

Apply on Nonanedioic acid own or mix with your favorite serum or moisturizer.
Nonanedioic acid is fine to apply it to the entire face, or you can target blemished areas as needed.
During the day, finish with a broad-spectrum sunscreen rated SPF 30 or greater.

The booster isn't an Nonanedioic acid cream or Nonanedioic acid gel; instead Nonanedioic acid is a gel-cream hybrid that's compatible with all skin types and can be used with any of our other products, including our exfoliants, which might lead you to wonder how Nonanedioic acid compares to AHA and BHA exfoliants.

Benefits of Nonanedioic acid for Skin:
Nonanedioic acid is a multifunctional skincare ingredient that tackles a multitude of concerns related to breakouts and inflammation.

Exfoliates gently:
Nonanedioic acid goes deep within the pores and removes dead skin cells that cause dull skin tone and clogged pores.

Fights acne:
Nonanedioic acid has antibacterial properties, and according to Fusco, Nonanedioic acid is reported to be bactericidal to P. acnes, which leads to acne.

Reduces inflammation:
Nonanedioic acid soothes irritation and helps to improve red bumps caused by inflammation.

Evens skin tone:
Nonanedioic acid inhibits tyrosinase, which is an enzyme that leads to hyperpigmentation.
Nonanedioic acid is effective on post-inflammatory hyperpigmentation from acne breakouts and can possibly have an effect on melasma as well.

Treats rosacea:
Nonanedioic acid could help with pore-clogging, inflammation, and secondary infections caused by rosacea.

Nonanedioic acid is a so-called carboxylic acid.
Nonanedioic acid is not an AHA or BHA but a distant relative to them (all being carboxylic acids).
Nonanedioic acid can be found naturally in wheat, rye, and barley.

Antibacterial effect → Anti-Acne:
Nonanedioic acid has a great antibacterial effect.
Nonanedioic acid works against multiple bacteriaS, acne-causing Propionibacterium acnes (P. acnes).
Very few ingredient are proven to work against P. acnes, so this alone makes Nonanedioic acid an awesome choice for acne-prone skin.

For acne treatment, 20% is the standard prescription strength choice.
Comparing 20% Nonanedioic acid to other acne treatments like 0.05% retinoic acid cream, 5% benzoyl peroxide cream or 2% erythromycin ointment Nonanedioic acid had nothing to be ashamed for as Nonanedioic acid showed similar effectiveness.

There is also a study that showed that 5% Nonanedioic acid is also somewhat effective (about 32% improvement) and Nonanedioic acid can be made much more effective by combining Nonanedioic acid with 2% clindamycin (about 64% improvement.)

Regulate the production of skin cells → Anti-Acne:
Nonanedioic acid also works on the cells that line hair follicles by changing the way they mature and proliferate, which decreases follicular ‘plugging’ and helps prevent blackheads, whiteheads, and inflamed acne lesions.
Nonanedioic acid helps with healthy skin cell production in the pores that is often problematic in acne and blackhead prone skin, which is nice!

Anti-inflammatory effect → Anti-rosacea, anti-acne:
The third magic property of Nonanedioic acid is that it is proven to ha an e anti-inflammatory effect.
This is cool not only for treating acne, but also for treating rosacea.
15% is the standard prescription strength dose for rosacea treatment.

Skin lightening effect → Anti-PIH, anti-melasma:
Last but not least Nonanedioic acid also shows skin lightening properties.
Nonanedioic acid seems to be especially effective for post-inflammatory hyperpigmentation (that often comes with acne) and melasma.

Studies have compared 20% Nonanedioic acid to 2% and 4% Hydroquinone and here again, Nonanedioic acid has nothing to be ashamed of, Nonanedioic acid showed similar skin lightening properties. (Though interestingly Nonanedioic acid did not seem to be effective for lightening age spots that are called solar lentigines.)

So the bottom line is that Nonanedioic acid can be a game changer (or rather skin changer) especially for acne-prone or rosacea skin types.
Nonanedioic acid is antibacterial, can regulate problematic skin cell production in pores, it’s anti-inflammatory and even helps with PIH and melasma.
Nonanedioic acid really can do a lot.

Nonanedioic acid keeps pores clear:
Nonanedioic acid is a comedolytic.
This means Nonanedioic acid helps break down existing pore blockages (AKA comedones) and keeps new ones from forming.
Clear pores and fewer pore blockages ultimately lead to fewer pimples.

Nonanedioic acid gently exfoliates:
Nonanedioic acid is also a keratolytic.
Keratolytics help your skin exfoliate by dissolving old, flaky skin cells.
Nonanedioic acid is a fairly gentle exfoliant, especially when compared to other acne treatments like topical retinoids.

Nonanedioic acid reduces acne-causing bacteria:
Nonanedioic acid kills Propionibacteria acnes, the bacteria that are responsible for inflamed acne breakouts.
This, in turn, reduces redness and inflammation.

Nonanedioic acid evens out your skin tone:
Another benefit of Nonanedioic acid Nonanedioic acid is ability to improve post-inflammatory hyperpigmentation, or those discolored spots pimples leave behind.
Complexions that are prone to hyperpigmentation will especially benefit from Nonanedioic acid.

Production of Nonanedioic acid:
Nonanedioic acid is industrially produced by the ozonolysis of oleic acid.
The side product is nonanoic acid.

Nonanedioic acid is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
The bacterial degradation of nonanoic acid gives Nonanedioic acid.

Biological function of Nonanedioic acid:
In plants, Nonanedioic acid serves as a "distress flare" involved in defense responses after infection.
Nonanedioic acid serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.

Action Mechanism of Nonanedioic acid:
The mechanism of action of Nonanedioic acid is not well understood.
However, in vitro, Nonanedioic acid possesses antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, most likely through microbial cellular protein synthesis inhibition.

Microcomedones and comedones can arise because of hyperkeratinization.
Nonanedioic acid produces an anticomedonal effect by decreasing the amount of hyperkeratinization.

Biopsies have shown a decrease in stratum corneum thickness, keratohyalin granules, and filaggrin in patients treated with Nonanedioic acid cream.
Nonanedioic acid also competitively inhibits tyrosinase, an enzyme involved in the conversion of tyrosine to melanin.

Last, Nonanedioic acid mechanism of action also includes the inhibition of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects on the melanocyte.
Therefore, Nonanedioic acid is thought to decrease postinflammatory hyperpigmentation.

Alternatives:
Currently, there are no other known drugs with the same mechanism of action as Nonanedioic acid.
On the other hand, there are many other drugs that can be used in the treatment of acne vulgaris, such as topical and oral retinoids, oral and topical antibiotics, benzoyl peroxide, topical dapsone, salicylic acid, photodynamic therapy, lasers, and peels.

Antibiotics develop resistance when not used in combination with benzoyl peroxide and therefore should not be used as monotherapy.
Nonanedioic acid is an effective monotherapy for acne vulgaris in pregnant women.

Handling and storage of Nonanedioic acid:

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage class:
Storage class (TRGS 510): 11: Combustible Solids

Stability and reactivity of Nonanedioic acid:

Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability:
Nonanedioic acid is chemically stable under standard ambient conditions (room temperature).

Possibility of hazardous reactions:
No data available

Conditions to avoid:
Strong heating.

Incompatible materials:
Bases, Reducing agents, Oxidizing agents

Warnings And Precautions
Hypersensitivity reactions have been reported with the use of Nonanedioic acid.
Nonanedioic acid should be avoided in patients with known hypersensitivity reactions to Nonanedioic acid or its components.

Hypopigmentation has been reported with the use of Nonanedioic acid as well.
Skin should be monitored for signs of hypopigmentation, especially in patients with dark complexions.
In addition, contact with the eyes, mouth, and other mucous membranes should be avoided.

First aid measures of Nonanedioic acid:

General advice:
Show this material safety data sheet to the doctor in attendance.

If inhaled:

After inhalation:
Fresh air.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.

In case of eye contact:

After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.

If swallowed:

After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.

Indication of any immediate medical attention and special treatment needed:
No data available

Firefighting measures of Nonanedioic acid:

Suitable extinguishing media:
Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture:
Carbon oxides
Combustible.

Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters:
Stay in danger area only with self-contained breathing apparatus.
Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

Accidental release measures of Nonanedioic acid:

Personal precautions, protective equipment and emergency procedures:

Advice for non-emergency personnel:
Avoid inhalation of dusts.
Avoid substance contact.

Ensure adequate ventilation.
Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions.

Take up dry.
Dispose of properly.

Clean up affected area.
Avoidgeneration of dusts.

Identifiers of Nonanedioic acid:
CAS Number: 123-99-9
Beilstein Reference: 1101094
ChEBI: CHEBI:48131
ChEMBL: ChEMBL1238
ChemSpider: 2179
DrugBank: DB00548
ECHA InfoCard: 100.004.246
EC Number: 204-669-1
Gmelin Reference: 261342
IUPHAR/BPS: 7484
KEGG: D03034
PubChem CID: 2266
UNII: F2VW3D43YT
CompTox Dashboard (EPA): DTXSID8021640
InChI: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N
InChI=1/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
Key: BDJRBEYXGGNYIS-UHFFFAOYAK
SMILES: O=C(O)CCCCCCCC(=O)O

CAS Number: 123-99-9
EC Number: 204-669-1

Chemical formula: C9H16O4
Molar mass: 188.22 g/mol
Appearance: white solid
Density: 1.443 g/mL
Melting point: 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point: 286 °C (547 °F; 559 K) at 100 mmHg
Solubility in water: 2.14 g/L
Acidity (pKa): 4.550, 5.498

Display Name: Nonanedioic acid
EC Number: 204-669-1
EC Name: Nonanedioic acid
CAS Number: 123-99-9
Molecular formula: C9H16O4
IUPAC Name: Azelaic acid

CAS number: 123-99-9
EC number: 204-669-1
Hill Formula: C₉H₁₆O₄
Chemical formula: HOOC(CH₂)₇COOH
Molar Mass: 188.22 g/mol
HS Code: 2917 13 90

Synonym(s): Azelaic acid
Linear Formula: HO2C(CH2)7CO2H

Properties of Nonanedioic acid:
Chemical formula: C9H16O4
Molar mass: 188.22 g/mol
Appearance: white solid
Density: 1.443 g/mL
Melting point: 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point: 286 °C (547 °F; 559 K) at 100 mmHg
Solubility in water: 2.14 g/L
Acidity (pKa): 4.550, 5.498

vapor density: 6.5 (vs air)
Quality Level: 200
vapor pressure: Assay: 98%
form: powder
bp: 286 °C/100 mmHg (lit.)
mp: 109-111 °C (lit.)
SMILES string: OC(=O)CCCCCCCC(O)=O
InChI: 1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI key: BDJRBEYXGGNYIS-UHFFFAOYSA-N

Boiling point: 237 °C (20 hPa)
Density: 1.029 g/cm3 (20 °C)
Flash point: 215 °C
Melting Point: 107 °C
pH value: 3.5 (1 g/l, H₂O)
Vapor pressure: Solubility: 2.4 g/l

Specifications of Nonanedioic acid:
Assay (GC, area%): ≥ 90.0 % (a/a)
Identity (IR): passes test

Pharmacology of Nonanedioic acid:
ATC code: D10AX03 (WHO)
Routes of
administration: Topical
Pharmacokinetics:
Bioavailability: Very low
Biological half-life: 12 h
Legal status:
AU: S2 (Pharmacy Only)
US: ℞-only

Names of Nonanedioic acid:

Preferred IUPAC name:
Nonanedioic acid
1,7-Heptanedicarboxylic acid
1,9-Nonanedioic acid
Acide azelaique
Acido azelaico
Acidum azelaicum
Anchoic acid
Azelaic acid
Azelaic acid
azelaic acid
Azelaic acid, technical grade
Azelex
Emerox 1110
Emerox 1144
Finacea
Heptanedicarboxylic acid
Lepargylic acid
Skinoren

CAS name:
Nonanedioic acid

IUPAC names:
1,7-Heptanedicarboxylic acid
AZELAIC ACID
Azelaic Acid
Azelaic acid
azelaic acid
Azelaic acid
azelaic acid
Azelainsäure
Azeleic Acid
Nonanedioic acid
nonanedioic acid
Nonanedioic acid
Nonanedionic acid

Trade names:
Crodacid DC1195
Ácido Azelaico

Her türlü deterjanda kullanılan, temizleme özelliği olan noniyonik yüzey aktif madde

Çok iyi emülgatör, stabilizan, ıslatıcı, hidrotrop özellik

Nonylphénoxypolyoxyéthylène; NP 9; NONOXYNOL-9, N° CAS : 14409-72-4; 26027-38-3(generic); 26571-11-9; 37205-87-1(generic); 68412-54-4; 9016-45-9(generic). Nom INCI : NONOXYNOL-9. Ses fonctions (INCI). Agent émulsifiant : Favorise la formation de mélanges intimes entre des liquides non miscibles en modifiant la tension interfaciale (eau et huile). Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. 4-Nonylphenol, branched and linear, ethoxylated . Noms français : ALPHA-(NONYL-4 PHENYL)-OMEGA-HYDROXY POLY(OXYETHANEDIYL-1,2); GLYCOLS, POLYETHYLENE, MONO(P-NONYLPHENYL) ETHER; Nonylphénoxypolyoxyéthylène; TETRA(OXYETHYLENE), ALPHA-(4-NONYLPHENYL)-OMEGA-HYDROXY-; TRIACONTA(OXYETHYLENE), ALPHA-(4-NONYLPHENYL)-OMEGA-HYDROXY-. Utilisation et sources d'émission: Fabrication de cosmétiques

NONYL ALCOHOL. N° CAS : 143-08-8, Nom INCI : NONYL ALCOHOL. Nom chimique : Nonan-1-ol. N° EINECS/ELINCS : 205-583-7. Classification : Alcool. Ses fonctions (INCI). Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques

NONYL NONOXYNOL-10, N° CAS : 9014-93-1. Nom INCI : NONYL NONOXYNOL-10. Classification : Composé éthoxylé, Alkylphénol. Ses fonctions (INCI); Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Noms français : DINONYLPHENOL, ETHOXYLATED;DINONYLPHENOL-ETHYLENE OXIDE ADDUCT; DINONYLPHENOXY POLYETHOXYLE; Dinonylphénol éthoxylé; POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-(DINONYLPHENYL)-.OMEGA.-HYDROXY-; POLYETHYLENE GLYCOL MONO(DINONYLPHENYL) ETHER; Éther mono(dinonylphénylique) du polyéthylène glycol. Utilisation et sources d'émission: Agent dispersant, agent moussant

Nonylphenol ethoxylated (EO 10); alkyl phenol ethoxylates free; Nonylphenol ethoxylated (EO 30); (EO 40) POE nonyl Phenyl Ether; Ethoxylated nonylphenol; Polyoxyethylene Nonylphenyl Ether; nonylphenyl polyethyleneglycol ether, nonionic; macrogol nonylphenyl ether; Polyethylene Mono(nonylphenyl)ether Glycols; CAS NO:25154-52-3

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