Alpha-Tocopherol Acetate is a natural product found in Myriactis humilis, Senegalia polyacantha, and Senegalia catechu with data available.
Alpha-Tocopherol Acetate is a natural tocopherol and one of the most potent antioxidant tocopherols.
CAS Number: 7695-91-2
CAS Number: 58-95-7 RRR-α-isomer
EC Number: 231-710-0
MDL number: MFCD00072042
Chemical formula: C31H52O3
SYNONYMS:
Vitamin E acetate, alpha-Tocopherol acetate, 58-95-7, Tocopherol acetate, Alfacol, Tocopheryl acetate, D-alpha-tocopherol acetate, D-ALPHA-TOCOPHERYL ACETATE, Ecofrol, Contopheron, Tofaxin, Econ, Ephynal acetate, Tokoferol acetate, Evipherol, Fertilvit, Tocopherex, Tocophrin, Erevit, Gevex, (+)-alpha-Tocopherol acetate, Combinal E, Epsilan-M, E-Toplex, E-Ferol, Endo E Dompe, Ephynal, Spondyvit, Juvela, alpha-Tocopheryl acetate, Copherol 1250, Covitol 1100, Covitol 1360, Vitamin Ealpha acetate, Vitamin E acetate, d-, Nanotopes, Simmyungsaengmosu, NatAc, Tinoderm E, Natur-E granulate, DL-alpha-Tocopheryl acetate, Lutavit E 50, (+)-alpha-Tocopheryl acetate, CCRIS 4389, (R,R,R)-alpha-Tocopheryl acetate, C31H52O3, EINECS 200-405-4, UNII-A7E6112E4N, (+-)-alpha-Tocopherol acetate, 52225-20-4, D-alpha tocoferil acetate, alpha-Tocopherol acetate, all rac, (2R,4'R,8'R)-alpha-Tocopheryl acetate, A7E6112E4N, DL-alpha-Tocopherylacetate, d-Alpha Tocopheryl Acetate, .alpha.-Tocopherol acetate, alpha-Tocopherol acetate, (2R,4'R,8'R)-, EINECS 231-710-0, MFCD00072052, RRR-alpha-tocopheryl acetate, (+)-alfa-tocopherol acetate, alpha-tocopheryl acetate, D-, D-.alpha.-Tocopherol acetate, Tocopheryl acetate, D-alpha-, Vitamin E Acetate (D-form), UNII-9E8X80D2L0, Vectan (TN), BRN 0097512, CCRIS 6054, 54-22-8, DTXSID1031096, CHEBI:32321, 9E8X80D2L0, D-|A-Tocopherol acetate, Tocopherolacetate, alpha-, DL-alpha tocopheryl acetate, EINECS 257-757-7, MFCD00072042, T-3376, d-Vitamin E acetate, Tocopherol acetate [JAN], .alpha.-Tocopheryl acetate, Tocopherol acetate (JP17), Tocopheryl Acetate, d-Alpha, CHEMBL1047, NCGC00166253-02, SCHEMBL22298, 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-, 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-, 6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, MLS001335985, MLS001335986, DTXCID601356, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*))), 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]], 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*))), DTXSID3021356, (+)-.alpha.-Tocopherol acetate, (+)-.alpha.-Tocopheryl acetate, DL-alpha-Tocopherylacetate (Vitamin E acetate), EC 231-710-0, Syntopherol acetate, HMS2230C20, 5-17-04-00169 (Beilstein Handbook Reference), Tox21_111491, Tox21_111564, Tox21_113467, Tox21_303444, ALPHA-TOCOPHEROL ACETATE, D-, ALPHA-TOCOPHEROL ACETATE. D-, LS-245, Rovimix E 50SD, (R,R,R)-.alpha.-Tocopheryl acetate, 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, AKOS025117621, NSC 755840, NSC-755840, Tox21_113467_1, [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate, 1406-70-8, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-, .ALPHA.-TOCOPHEROL ACETATE, D-, CAS-58-95-7, NCGC00095255-08, NCGC00166253-01, NCGC00257504-01, DL--Tocopherol acetate, AS-13784, J24.807J, LS-39402, LS-53371, SMR000857327, CAS-52225-20-4, O-Acetyl-alpha-tocopherol, (2R,4'R,8'R)-.alpha.-Tocopheryl acetate, DL-alpha-Tocopherol acetate, >=96% (HPLC), Vitamin E acetate dl-form, 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, C13202, D01735, DL-alpha-Tocopherol acetate, analytical standard, [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] acetate, 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-b- enzopyran-6-ol, acetate, d,l-alpha-Tocopheryl acetate, Eusovit, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, 6-acetate, (2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-rel-, D-.alpha.-Tocopheryl acetate, Alpha-tocopherol acetate, dl-, Q-201933, vitamin E acetate, (2R-(2R*(4R*,8R*)))-isomer, W-109259, ECA8C22F-B5D3-4B88-A9B7-AF6C600001BB, vitamin E acetate, ((2R*(4R*,8R*))-(+-))-isomer, DL-alpha-Tocopherol acetate, tested according to Ph.Eur., DTXCID60196594, OptoVit E, SynAC, Rovimix E 50, Alpha Tocopheryl Acetate, United States Pharmacopeia (USP) Reference Standard, alpha-Tocopherol acetate, European Pharmacopoeia (EP) Reference Standard, DL-alpha-Tocopherol acetate, certified reference material, TraceCERT(R), DL-alpha-Tocopherylacetate (Vitamin E acetate) 10 microg/mL in Acetonitrile, (+)-alpha-Tocopherol acetate, BioReagent, suitable for insect cell culture, ~1360 IU/g, (R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate, 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate #, Tocopheryl Acetate, a, Pharmaceutical Secondary Standard; Certified Reference Material, (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate, (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate, (2R*(4R*,8R*))-(1)-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, [2R-[2R*(4R,8R*)]]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate, 2H-1-benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2R*(4R*,8R*))), 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate,(2R*(4R*,8R*))-(+-)-, All-rac-alpha-tocopheryl acetate for peak identification, European Pharmacopoeia (EP) Reference Standard, Tocopheryl acetate,alpha, Alpha Tocopheryl Acetate, D-ALPHA TOCOFERIL ACETATE (M), UNII-WR1WPI7EW8, Copherol 12250, d-|ATocopheryl Acetate, O-Acetyl-|A-tocopherol, alpha-Tocopherylis acetas, AC1L3BMH, DL-|A-Tocopheryl acetate, .alpha.-tocopherol acetate, dl-, AC1Q1PB2, (+)-|A-Tocopherol acetate, (+)-|A-Tocopheryl Acetate, all-rac-|A-Tocopheryl acetate, DL-ALPHA-TOCOPHEROLACETATE, C31-H52-O3, (R,R,R)-|A-Tocopheryl Acetate, (2R,4'R,8'R)-alpha-Tocopherol acetate, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-rel-, Tocopherol, acetate, Acetate, Tocopherol, ZINC4172337, alpha-tocopherylacetat, FT-0624407, a- tocopheryl acetate, D--Tocopherol acetate, (2R,4'R,8'R)-|A-Tocopherol Acetate, (2R,4'R,8'R)-|A-Tocopheryl Acetate, SC-16401, SC-18242, alpha Tocopherol Acetate, DSSTox_CID_1356, d alpha Tocopheryl Acetate, DL-alpha-Tocopherol acetate, 50% powder form, J10308, DL-alpha-Tocopherol acetate, EP/USP/FCC grade, DSSTox_RID_76104, DSSTox_RID_78863, DSSTox_GSID_21356, DSSTox_GSID_31096, Vitamin E acetate (unlabeled), VITAMIN E ALPHA ACETATE, (+)- alpha -Tocopherol acetate, TOCOPHERYL ACETATE,D-ALPHA, D-alpha-Tocopheryl acetate, 97%, MolPort-003-928-528, DL-alpha-Tocopheryl acetate, 98%, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl- 2-(4,8,12-trimethyltridecyl)-, acetate, 3, 4- dihydro- 2, 5, 7, 8- tetramethyl- 2- (4, 8, 12- trimethyltridecyl)- 2H- benzopyran- 6- yl acetate, HY-B1278, TOCOPHERYL ACETATE [WHO-DD], Vitamin E acetate, unspecified form, TOCOPHERYL ACETATE, alpha, D-, s3681, Vitamin E (alpha tocopherol acetate), 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate, CCG-269474, CS-O-00415, DB14002, .ALPHA.-TOCOPHEROL ACETATE. D-, (+-)-alpha-Tocopherol Acetateacid ester, .ALPHA.-TOCOPHEROL ACETATE [MI], TOCOPHERYL ACETATE, .ALPHA., D-, (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol 6-Acetate, [2R*(4R*,8R*)]-()-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, 133-80-2, 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,6-acetate, (2R)-, AK176402, all-rac-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate, ALPHA TOCOPHERYL ACETATE (USP-RS), RRR-ALPHA-TOCOPHERYL ACETATE [FCC], TOCOPHERYL ACETATE,D-ALPHA [VANDF], CS-0013056, T2322, VITAMIN E (ALPHA-TOCOPHERYL ACETATE), A11606, D70796, alpha-TOCOPHEROL ACETATE, UNSPECIFIED FORM, EN300-7398027, A865381, Q364160, Z2681891483, UNII-WR1WPI7EW8 component ZAKOWWREFLAJOT-CEFNRUSXSA-N, Vitamin E acetate (dimethyl-13C2, acetyl-13C2, 99%; dimethyl-D6, 98%), (+)-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL ACETATE, (2R-(2R*(4R*,8R*)))-3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRI-DECYL)-2H-1-BENZOPYRAN-6-OL ACETATE, [2R*(4R*,8R*)]-(+-)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, 12741-00-3, 1407-18-7, 26243-95-8, 2H-1-Benzopiran-6-ol, 3,4-dihidro-2,5,7,8-tetrametil-2-[(4R,8R)-4,8,12-trimetiltridecil]-, 6-acetato, (2R)-rel-, 2H-1-benzopirano-6-ol, 3,4-dihidro-2,5,7,8-tetrametil-2-[(4R, 8R)-4,8,12-trimetiltridecil]-, 6-acetato, ( 2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl- 2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R(4R,8R)]]-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R*(4R*,8R*)]-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R*(4R*,8R*)]-(.+.)-, 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,acetate, (2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-, Vitamin E acetate; 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-, α-Tocopherol acetate, (+)-α-Tocopherol acetate, (+)-α-Tocopheryl acetate, D-α-tocopherol acetate, D-α-tocopheryl acetate, Alfacol, Combinal E, Contopheron, E-Ferol, E-Toplex, Ecofrol, Econ, Endo E Dompe, Ephynal acetate, Eps, UNII-WR1WPI7EW8, Copherol 12250, d-|ATocopheryl Acetate, O-Acetyl-|A-tocopherol, alpha-Tocopherylis acetas, AC1L3BMH, DL-|A-Tocopheryl acetate, .alpha.-tocopherol acetate, dl-, AC1Q1PB2, (+)-|A-Tocopherol acetate, (+)-|A-Tocopheryl Acetate, all-rac-|A-Tocopheryl acetate, DL-ALPHA-TOCOPHEROLACETATE, C31-H52-O3, (R,R,R)-|A-Tocopheryl Acetate, (2R,4'R,8'R)-alpha-Tocopherol acetate, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-rel-, Tocopherol, acetate, Acetate, Tocopherol, ZINC4172337, alpha-tocopherylacetat, FT-0624407, a- tocopheryl acetate, D--Tocopherol acetate, (2R,4'R,8'R)-|A-Tocopherol Acetate, (2R,4'R,8'R)-|A-Tocopheryl Acetate, SC-16401, SC-18242, alpha Tocopherol Acetate, DSSTox_CID_1356, d alpha Tocopheryl Acetate, DL-alpha-Tocopherol acetate, 50% powder form, J10308, DL-alpha-Tocopherol acetate, EP/USP/FCC grade, DSSTox_RID_76104, DSSTox_RID_78863, DSSTox_GSID_21356, DSSTox_GSID_31096, Vitamin E acetate (unlabeled), VITAMIN E ALPHA ACETATE, (+)- alpha -Tocopherol acetate, TOCOPHERYL ACETATE,D-ALPHA, D-alpha-Tocopheryl acetate, 97%, MolPort-003-928-528, DL-alpha-Tocopheryl acetate, 98%, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl- 2-(4,8,12-trimethyltridecyl)-, acetate, 3, 4- dihydro- 2, 5, 7, 8- tetramethyl- 2- (4, 8, 12- trimethyltridecyl)- 2H- benzopyran- 6- yl acetate, HY-B1278, TOCOPHERYL ACETATE [WHO-DD], Vitamin E acetate, unspecified form, TOCOPHERYL ACETATE, alpha, D-, s3681, Vitamin E (alpha tocopherol acetate), 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate, CCG-269474, CS-O-00415, DB14002, .ALPHA.-TOCOPHEROL ACETATE. D-, (+/-)-alpha-Tocopherol Acetateacid ester, .ALPHA.-TOCOPHEROL ACETATE [MI], TOCOPHERYL ACETATE, .ALPHA., D-, (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol 6-Acetate, [2R*(4R*,8R*)]-()-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, 133-80-2, 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,6-acetate, (2R)-, AK176402, all-rac-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate, ALPHA TOCOPHERYL ACETATE (USP-RS), RRR-ALPHA-TOCOPHERYL ACETATE [FCC], TOCOPHERYL ACETATE,D-ALPHA [VANDF], CS-0013056, T2322, VITAMIN E (ALPHA-TOCOPHERYL ACETATE), A11606, D70796, alpha-TOCOPHEROL ACETATE, UNSPECIFIED FORM, EN300-7398027, A865381, Q364160, Z2681891483, UNII-WR1WPI7EW8 component ZAKOWWREFLAJOT-CEFNRUSXSA-N, Vitamin E acetate (dimethyl-13C2, acetyl-13C2, 99%; dimethyl-D6, 98%), (+)-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL ACETATE, (2R-(2R*(4R*,8R*)))-3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRI-DECYL)-2H-1-BENZOPYRAN-6-OL ACETATE, [2R*(4R*,8R*)]-(+-)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, 12741-00-3, 1407-18-7, 26243-95-8, 2H-1-Benzopiran-6-ol, 3,4-dihidro-2,5,7,8-tetrametil-2-[(4R,8R)-4,8,12-trimetiltridecil]-, 6-acetato, (2R)-rel-, 2H-1-benzopirano-6-ol, 3,4-dihidro-2,5,7,8-tetrametil-2-[(4R, 8R)-4,8,12-trimetiltridecil]-, 6-acetato, ( 2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R(4R,8R)]]-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R*(4R*,8R*)]-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R*(4R*,8R*)]-(.+.)-, 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,acetate, (2R)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-, Vitamin E acetate; 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-, α-Tocopherol acetate, (+)-α-Tocopherol acetate, (+)-α-Tocopheryl acetate, D-α-tocopherol acetate, D-α-tocopheryl acetate, Alfacol, Combinal E, Contopheron, E-Ferol, E-Toplex, Ecofrol, Econ, Endo E Dompe, Ephynal acetate, Epsilan,
Alpha-Tocopherol Acetate, also known as a-tocopherol acetic acid, belongs to the class of organic compounds known as vitamin e compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
Based on a literature review a significant number of articles have been published on alpha-Tocopherol acetate.
Alpha-Tocopherol Acetate belongs to the class of organic compounds known as vitamin e compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
Alpha-Tocopherol Acetate, also known as a-tocopherol acetic acid, belongs to the class of organic compounds known as vitamin e compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
Based on a literature review a significant number of articles have been published on Alpha-Tocopherol Acetate.
Alpha-Tocopherol Acetate is a natural product found in Myriactis humilis, Senegalia polyacantha, and Senegalia catechu with data available.
Alpha-Tocopherol Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties.
Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), Alpha-Tocopherol Acetate is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols).
Alpha-Tocopherol Acetate is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production.
Alpha-Tocopherol Acetate also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
Alpha-Tocopherol Acetate is a natural tocopherol and one of the most potent antioxidant tocopherols.
Alpha-Tocopherol Acetate exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus.
Alpha-Tocopherol Acetate has four methyl groups on the 6-chromanol nucleus.
The natural d form of Alpha-Tocopherol Acetate is more active than its synthetic dl-alpha-tocopherol racemic mixture.
Alpha-Tocopherol Acetate appears as odorless off-white crystals.
Alpha-Tocopherol Acetate is a tocol.
Alpha-Tocopherol Acetate, also known simply as tocopheryl acetate, is a synthetic form of vitamin E found in dietary supplements and skin care products.
Alpha-Tocopherol Acetate is considered the most stable and active form of vitamin E and the best option overall for treating vitamin E deficiency.
Alpha-Tocopherol Acetate is marketed to prevent several health conditions or diseases.
Yet, research on Alpha-Tocopherol Acetate and vitamin E supplementation, in general, has not proven many of these health claims.
Alpha-Tocopherol Acetate is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements.
Alpha-tocopherol acetate is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in vitamin E.
Alpha-Tocopherol Acetate itself is naturally found in various foods, added to others, or used in commercially available products as a dietary supplement.
The recommended dietary allowances (RDAs) for Alpha-Tocopherol Acetate are: males = 4 mg (6 IU) females = 4 mg (6 IU) in ages 0-6 months, males = 5 mg (7.5 IU) females = 5 mg (7.5 IU) in ages 7-12 months, males = 6 mg (9 IU) females = 6 mg (9 IU) in ages 1-3 years, males = 7 mg (10.4 IU) females = 7 mg (10.4 IU) in ages 4-8 years, males = 11 mg (16.4 IU) females = 11 mg (16.4 IU) in ages 9-13 years, males = 15 mg (22.4 IU) females = 15 mg (22.4 IU) pregnancy = 15 mg (22.4 IU) lactation = 19 mg (28.4 IU) in ages 14+ years 5.
Alpha-Tocopherol Acetate is also added to fortified foods, such as cereals, fruit juices, and many spreads.
You can check food labels to see if Alpha-Tocopherol Acetate has been added.
If you want to increase your Alpha-Tocopherol Acetate intake, you should start by first increasing your intake of these foods.
Alpha-Tocopherol Acetate is a specific form of vitamin E that’s often found in skin care products and dietary supplements.
Alpha-Tocopherol Acetate’s also known as tocopheryl acetate, tocopherol acetate, or vitamin E acetate.
Alpha-Tocopherol Acetate, also known as vitamin E acetate, is a form of vitamin E with D-Alpha Tocpheryl Acetate as the natural form and DL-Alpha Tocopheryl Acetate as the synthetic form.
Alpha-Tocopherol Acetate indicates the synthetic form where as D- indicates the natural form.
Alpha-Tocopherol Acetate is the ester of acetic acid and α-tocopherol.
Alpha-Tocopherol Acetate is known for its antioxidant properties.
Antioxidants help to protect your body from damaging compounds called free radicals.
Normally, free radicals form when your body converts food into energy.
However, free radicals can also come from UV light, cigarette smoke, and air pollution.
In nature, Alpha-Tocopherol Acetate comes in the form of tocopheryl or tocotrienol.
Both tocopheryl and tocotrienol have four forms, known as alpha, beta, gamma, and delta.
Alpha-tocopheryl (AT) is the most active form of vitamin E in humans.
Alpha-Tocopherol Acetate is more stable than Alpha-Tocopherol, meaning it can better withstand environmental stresses such as heat, air, and light.
This makes Alpha-Tocopherol Acetate ideal for use in supplements and fortified foods because it has a longer shelf life.
USES and APPLICATIONS of ALPHA-TOCOPHEROL ACETATE:
Alpha-Tocopherol Acetate has many proposed uses, primarily because of its antioxidant properties, which are thought to protect cells from free radicals.
In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of Alpha-Tocopherol Acetate and generally exhibits the greatest bioavailability out of all of the alpha-tocopherol stereoisomers.
Moreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed.
Alpha-tocopherol acetate is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in vitamin E.
Vitamin E itself is naturally found in various foods, added to others, or used in commercially available products as a dietary supplement.
In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the alpha-tocopherol stereoisomers.
Moreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed 2.
Although there is widespread use of Alpha-Tocopherol Acetate as a topical medication, with claims for improved wound healing and reduced scar tissue, reviews have repeatedly concluded that there is insufficient evidence to support these claims.
There are reports of Alpha-Tocopherol Acetate-induced allergic contact dermatitis from use of vitamin E derivatives such as tocopheryl linoleate and tocopherol acetate in skin care products.
Due to its higher stability, Alpha-Tocopherol Acetate is also used in vitamin E dietary supplements.
When taken orally, Alpha-Tocopherol Acetate is converted to AT within the intestine.
Alpha-Tocopherol Acetate is in most multi-vitamins, so be sure to check how much is in your multi-vitamin if you take one, before adding a supplement.
Alpha-Tocopherol Acetate usually needs to be used with other vitamins and minerals to have a beneficial effect.
Alpha-Tocopherol Acetate is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements.
-Use in cosmetics
Alpha-Tocopherol Acetate is often used in dermatological products such as skin creams.
Alpha-Tocopherol Acetate is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol.
Alpha-Tocopherol Acetate claims are made for beneficial antioxidant effects.
Alpha-Tocopherol Acetate is used as an alternative to tocopherol itself because the phenolic hydroxyl group is blocked, providing a less acidic product with a longer shelf life.
It is believed that the acetate is slowly hydrolyzed after Alpha-Tocopherol Acetate is absorbed into the skin, regenerating tocopherol and providing protection against the sun's ultraviolet rays.
Alpha-Tocopherol Acetate was first synthesized in 1963 by workers at Hoffmann-La Roche.
-Marketed but unproven uses of Alpha-Tocopherol Acetate include:
*Reducing inflammation,
*Preventing heart disease,
*Preventing cancer,
*Promoting wound healing,
*Slowing cognitive decline,
*Slowing the progression of macular degeneration (eye disease affecting central vision),
-Uses of Tocopheryl Acetate
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider.
No supplement is intended to treat, cure, or prevent disease.
WHERE CAN I FIND ALPHA-TOCOPHEROL ACETATE?
*Cosmetics and supplements
You’ll find Alpha-Tocopherol Acetate in a variety of skin care products.
The antioxidant properties of Alpha-Tocopherol Acetate can help to prevent damage to skin caused by free radicals from UV exposure.
Alpha-Tocopherol Acetate may also have an anti-inflammatory effect on the skin.
ALTERNATIVE PARENTS OF ALPHA-TOCOPHEROL ACETATE:
*Diterpenoids
*1-benzopyrans
*Alkyl aryl ethers
*Benzenoids
*Carboxylic acid esters
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds
SUBSTITUENTS OF ALPHA-TOCOPHEROL ACETATE:
*Diterpenoid
*Chromane
*Benzopyran
*1-benzopyran
*Alkyl aryl ether
*Benzenoid
*Carboxylic acid ester
*Carboxylic acid derivative
*Oxacycle
*Organoheterocyclic compound
*Ether
*Monocarboxylic acid or derivatives
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Carbonyl group
*Organooxygen compound
*Aromatic heteropolycyclic compound
FOODS, ALPHA-TOCOPHEROL ACETATE:
In addition to dietary supplements and cosmetic products, you can find Alpha-Tocopherol Acetate in the following foods:
**green leafy vegetables, such as broccoli and spinach
**oils, such as sunflower oil, wheat germ oil, and corn oil
**sunflower seeds
**nuts, such as almonds and peanuts
**whole grains
**fruits, such as kiwi and mango
POTENTIAL BENEFITS OF ALPHA-TOCOPHEROL ACETATE:
Using AT on the skin, especially with vitamin C, helps to prevent UV damage to the skin.
In a review of studies, the Linus Pauling Institute at Oregon State University found that using AT with vitamin C on the skin decreased sunburned cells, DNA damage, and skin pigmentation following UV exposure.
However, AT is less stable in the environment than Alpha-Tocopherol Acetate, which makes it harder to store.
While Alpha-Tocopherol Acetate is less sensitive to heat and light than AT is, there’s less conversion of ATA to the active AT form within the skin.
This is because the cells in the upper layer of your skin are much less metabolically active.
As a result, using cosmetic products containing Alpha-Tocopherol Acetate on your skin may not be very effective.
CHEMISTRY OF ALPHA-TOCOPHEROL ACETATE:
At room temperature, Alpha-Tocopherol Acetate is a fat-soluble liquid.
Alpha-Tocopherol Acetate has 3 chiral centers and thus 8 stereoisomers.
Alpha-Tocopherol Acetate is made by esterifying α-tocopherol with acetic acid.
2R,4R,8R-isomer, also known as RRR-α-tocopheryl acetate, is the most common isomer used for various purposes.
This is because α-tocopherol occurs in nature primarily as RRR-α-tocopherol.
Alpha-Tocopherol Acetate does not boil at atmospheric pressure and begins to degrade at 240 °C.
Alpha-Tocopherol Acetate can be vacuum distilled: it boils at 184 °C at 0.01 mmHg, at 194 °C (0.025 mmHg) and at 224 °C (0.3 mmHg).
In practice, Alpha-Tocopherol Acetate is not degraded notably by air, visible light or UV-radiation.
Alpha-Tocopherol Acetate has a refractive index of 1.4950–1.4972 at 20 °C.
Alpha-Tocopherol Acetate is hydrolyzed to α-tocopherol and acetic acid under suitable conditions or when ingested by people.
PHYSICAL and CHEMICAL PROPERTIES of ALPHA-TOCOPHEROL ACETATE:
Chemical formula: C31H52O3
Molar mass: 472.743 g/mol
Appearance: pale yellow, viscous liquid
Melting point: –27.5 °C
Boiling point: 240 °C decays without boiling
Solubility in water: insoluble
Solubility: soluble in acetone, chloroform, diethyl ether; poorly soluble in ethanol
Molecular Weight: 472.7 g/mol
XLogP3-AA: 10.8
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 14
Exact Mass: 472.39164552 g/mol
Monoisotopic Mass: 472.39164552 g/mol
Topological Polar Surface Area: 35.5Ų
Heavy Atom Count: 34
Formal Charge: 0
Complexity: 602
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Appearance Form: liquid
Odor: No data available
Odor Threshold: No data available
pH: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: 224 °C at 0,4 hPa
Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available
Density: No data available
Relative density: 0,95 - 0,964 at 25 °C
Water solubility: 0,0008 g/l at 20 °C slightly soluble
Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: 5706 mm2/s at 20 °C
Viscosity, dynamic: 701 mPa.s at 40 °C
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Water Solubility: 2.9e-06 g/L
logP: 9.19
logP: 10.42
logS: -8.2
pKa (Strongest Basic): -4.9
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 0
Polar Surface Area: 35.53 Ų
Rotatable Bond Count: 14
Refractivity: 144.53 m³·mol⁻¹
Polarizability: 60.23 ų
Number of Rings: 2
Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Chemical Formula: C31H52O3
IUPAC name: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
InChI Identifier: InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
InChI Key: ZAKOWWREFLAJOT-UHFFFAOYSA-N
Isomeric SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(C)=O)=C(C)C(C)=C2O1
Average Molecular Weight: 472.7428
Monoisotopic Molecular Weight: 472.39164553
IUPAC Name: [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate
Molecular Weight: 472.74
Molecular Formula: C31H52O3
Canonical SMILES: CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)C)C
InChI: InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1
InChIKey: ZAKOWWREFLAJOT-CEFNRUSXSA-N
Boiling Point: 224°C0.3mm Hg(lit.)
Melting Point: 28°C
Flash Point: >230 °F
Density: 0.953 g/mL at 25 °C(lit.)
Solubility: Soluble in Chloroform (Slightly), Ethanol (Slightly, Sonicated), Ethyl Acetate (Slightly)
Appearance: Colourless to Light Yellow Thick Oil to Low-Melting Solid
Application: anticoagulant
Storage: -20°C
Assay: 0.9999
EINECS: 200-405-4
MDL: MFCD00072052
Refractive Index: 1.494-1.498
Stability: Stable.
Chemical Formula: C31H52O3
Molar Mass: 472.743 g/mol
Appearance: Pale yellow, viscous liquid
Melting Point: –27.5 °C
Boiling Point: 240 °C (decays without boiling)
Solubility in Water: Insoluble
Solubility: Soluble in acetone, chloroform, diethyl ether; poorly soluble in ethanol
Chemical Formula: C31H52O3
Average Molecular Weight: 472.7428
Monoisotopic Molecular Weight: 472.39164553
IUPAC Name: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
Traditional Name: Tocopheryl acetate
CAS Registry Number: 58-95-7
SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(C)=O)=C(C)C(C)=C2O1
InChI Identifier: InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
InChI Key: ZAKOWWREFLAJOT-UHFFFAOYSA-N
Water Solubility: 2.9e-06 g/L
logP: 9.19
logP: 10.42
logS: -8.2
pKa (Strongest Basic): -4.9
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 0
Polar Surface Area: 35.53 Ų
Rotatable Bond Count: 14
Refractivity: 144.53 m³·mol⁻¹
Polarizability: 60.23 ų
Number of Rings: 2
Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Chemical Formula: C31H52O3
IUPAC Name: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
InChI Identifier: InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
InChI Key: ZAKOWWREFLAJOT-UHFFFAOYSA-N
Isomeric SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(C)=O)=C(C)C(C)=C2O1
Average Molecular Weight: 472.7428
Monoisotopic Molecular Weight: 472.39164553
FIRST AID MEASURES of ALPHA-TOCOPHEROL ACETATE:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of ALPHA-TOCOPHEROL ACETATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of ALPHA-TOCOPHEROL ACETATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of ALPHA-TOCOPHEROL ACETATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of ALPHA-TOCOPHEROL ACETATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
*Storage stability:
Recommended storage temperature: 2 - 8 °C
STABILITY and REACTIVITY of ALPHA-TOCOPHEROL ACETATE:
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available