Detergents, Cosmetics, Disinfectants, Pharma Chemicals

Maltodextrine
MALTODEXTRIN, N° CAS : 9050-36-6 - Maltodextrine, Origine(s) : Végétale. Autres langues : Maltodestrina, Maltodextrina. Nom INCI : MALTODEXTRIN. N° EINECS/ELINCS : 232-940-4. La maltodextrine est un sucre obtenu par l'hydrolyse de l'amidon de maïs, de l'amidon de riz ou de fécule de pomme de terre. Elle le plus souvent utilisée en alimentaire, pour apporter des suppléments en glucide aux aliments. On en trouve dans les boissons énergisantes dédiées les athlètes. En cosmétique, elle est utilisée comme stabilisateur de formule ou encore comme agent filmogène. Ses fonctions (INCI) Agent Absorbant : Absorbe l'eau (ou l'huile) sous forme dissoute ou en fines particules Agent fixant : Permet la cohésion de différents ingrédients cosmétiques Stabilisateur d'émulsion : Favorise le processus d'émulsification et améliore la stabilité et la durée de conservation de l'émulsion Agent filmogène : Produit un film continu sur la peau, les cheveux ou les ongles Conditionneur capillaire : Laisse les cheveux faciles à coiffer, souples, doux et brillants et / ou confèrent volume, légèreté et brillance Agent d'entretien de la peau : Maintient la peau en bon état
Malus domestica
malus domestica fruit water; aqueous solution of the steam distillates derived from the fruit of malus domestica; malus pumila fruit water; apple fruit water CAS NO:89957-48-2
m-Aminophenol
SYNONYM :3-Aminophenol , 3-Amino-1-hydroxybenzene m-hydroxyaminobenzene 3-Hydroxyaniline m-hydroxyphenylamine M-Aminophenol m-amino phenol Meta Aminophenol Aminophenol, 3- cas :591-27-5
Mandalina Yağı
MANDARIN OIL ; oil expressed from the peel of the mandarin, citrus nobilis, rutaceae; oil mandarin rectified; mandarin red oil organic ; mandarin oil green; mandarin deco CAS NO:8008-31-9
MANDELIC ACID
MANDELIC ACID = 2-HYDROXY-2-PHENYLACETIC ACID = PHENYLGLYCOLIC ACID


CAS Number: 90-64-2
EC Number: 202-007-6
MDL Number: MFCD00064250
Chemical formula: C8H8O3


Mandelic acid is chiral.
Mandelic acid is an alpha hydroxy acid (AHA) derived from bitter almonds.
Mandelic acid is even aptly named after the German word for almond: mandel, board-certified dermatologist Adeline Kikam, DO, tells Allure.
Among its fellow AHAs, like glycolic and lactic acids, mandelic acid has one of the largest particle sizes, allowing it to absorb into skin more "slowly, uniformly, and superficially,".


Mandelic acid also stays on the surface of skin longer.
Mandelic acid is also one of the best acid selections for those with darker complexions because Mandelic acid isn't melanotoxic.
In other words, Mandelic acid doesn't kill melanocytes and won't exacerbate discoloration.
Instead, Mandelic acid will decrease the appearance of dark spots due to acne, sun exposure, or otherwise in all the right ways


Mandelic acid peels are considered well-tolerated in patients of color with less risk of hyperpigmentation, photosensitivity, and scarring compared to other AHAs, like glycolic acid.
Despite Mandelic acid's larger particle size, mandelic acid also delves deeper into skin than other AHAs because it's oil-soluble.
Mandelic acid is an aromatic alpha hydroxy acid with the molecular formula C6H5CH(OH)CO2H.


Mandelic acid is a white crystalline solid that is soluble in water and polar organic solvents.
Mandelic acid is one of beneficial ingredients.
While there's not a lot of research on this alpha hydroxy acid (AHA), Mandelic acid is thought to be gentle on the skin and may help with acne, skin texture, hyperpigmentation, and the effects of aging.


Mandelic acid is derived from bitter almonds.
Mandelic acid is an AHA that's been mostly studied for use with acne.
Other types of AHAs found in skin care lines include glycolic acid and citric acid.


Mandelic acid is a 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups.
Mandelic acid has a role as an antibacterial agent and a human xenobiotic metabolite.
Mandelic acid is a 2-hydroxy monocarboxylic acid and a member of benzenes.


Mandelic acid is functionally related to an acetic acid.
Mandelic acid is a conjugate acid of a mandelate.
Mandelic acid is an approved aromatic, alpha hydroxy acid.


Mandelic acid is an aromatic AHA with the molecular formula C8H8O3.
Mandelic acid is a white crystalline solid that is soluble in water and most common organic solvents.
Mandelic acid can be combined with SA for the treatment of acne vulgaris.


Naturally derived from bitter almonds, Mandelic Acid is a gentler alpha hydroxy acid (AHA) that targets acne, age spots, discoloration and wrinkles without the typical irritation that can trigger post-inflammatory hyperpigmentation especially in darker skin tones.
Mandelic acid undergoes resolution to form (+)- and (-)-enantiomers that are widely used as chiral resolving agents in enantioseparation of various other racemates via salt formation.


Mandelic acid is also known as amygdalic acid
An alpha hydroxy acid (AHA) that can exfoliate skin.
Generally more tolerable for those with sensitive skin.
Must be in opaque packaging to maintain Mandelic acid's effectiveness.


Mandelic acid is a type of alpha hydroxy acid (AHA).
There’s some research showing mandelic acid is an effective exfoliant, although it’s not as effective as glycolic acid due to its larger size (it’s twice as big as glycolic acid) and slower penetration into skin.
These traits can also make mandelic acid more tolerable for those with sensitive skin.
Unlike glycolic acid, mandelic acid is light-sensitive and must be packaged in an opaque container to remain effective.


Mandelic acid may be synthetic or derived from almonds.
Like other AHAs, mandelic acid is most effective in leave-on products that are within a 3-4 pH range.
Mandelic acid and salicylic acid worked well together in a higher-strength peel for use on darker skin tones struggling with discolorations, including post-acne marks.
Mandelic acid can increase sebum (oil) production, which isn’t great for oily skin but would be a benefit for dry skin.


Mandelic acid is a superficial chemical peel that typically has comparatively fewer side effects and less downtime than other chemical peels and can be both safe and effective for several skin conditions.
Mandelic acid is an alpha hydroxy acid (AHA) derived from bitter almonds, but is more gentle than some of the other AHAs like glycolic acid and lactic acid.


AHAs work by exfoliating the layers of dead skin away by breaking the bonds between cells to reveal brighter, clearer skin as well as help to clear pores and create a more even tone.
Mandelic acid has a unique chemical structure, which results in a more uniform penetration through lipid-rich areas of the skin.
The desired effects of mandelic acid tend to be subtler than those of glycolic acid chemical peels.


Mandelic acid chemical peels are easier to recover from — and their side effects tend to be less pronounced — than their glycolic acid counterparts.
Additionally, mandelic acid chemical peels are just as useful for treating acne as salicylic acid chemical peels while being much less likely to cause side effects.
A salicylic-mandelic acid-based peel showed significant improvements in acne lesions.


Along with other acid-based chemical peels, mandelic acid chemical peels do not penetrate very deeply into the skin to achieve their effects.
Chemical peels of this variety are known as superficial peels.
Mandelic acid has a larger molecular structure than other acids, such as glycolic and salicylic, so it does not penetrate as deeply.
Mandelic acid is not some new, top-secret ingredient we've never heard before.


Mandelic acid is another form of an ingredient we've come to know and love for our skin.
Mandelic acid is an alpha hydroxy acid (AHA).
AHAs are good for the skin, as they work to loosen connections between impacted surface skin cells (called desmosomes) to allow the cells to shed naturally leading to a fresher, brighter complexion.
Mandelic acid is an alpha hydroxy acid derived from almonds.


All AHAs function to exfoliate the skin (and increase sun sensitivity, so sunscreen is a key part of using any AHA regimen).
Mandelic acid is usually found in combination with other products, and functions to improve skin texture via exfoliation.
Mandelic acid's molecular structure is what makes it so unique.
Larger in molecular weight compared to glycolic acid (another type of AHA) so Mandelic acid may be gentler on skin as it penetrates more slowly.


Mandelic acid belongs to a group of alpha hydroxyl acids (AHA). It has exfoliating, antibacterial and anti-aging effects.
Works to accelerate cell turnover for a youthful complexion.
Mandelic acid has a higher molecular mass in comparison to glycolic acid, Mandelic acid has considerably milder effect and is safe.


Mandelic acid does not make the skin sensitive to sun.
Mandelic is an aromatic alpha hydroxy acid (AHA).
Although originally derived from amygdalin, an extract from almonds, most mandelic acid today is synthetically produced.


Because of Mandelic acid's larger molecular structure relative to other AHAs like glycolic acid, mandelic acid is known to have slower penetration into the skin, which in part moderates its irritation potential to the skin.
By implication, the speed of action from a mandelic acid application may be slower or more gradual than some other AHA acids, and its use may be more appropriate for sensitive skin applications.


Mandelic acid is naturally derived from bitter almonds, and it works by gently exfoliating the skin.
Mandelic acid loosens the bonds that hold dead cells on the surface of the skin allowing, them to shed more effectively.
What sets mandelic acid apart from its AHA cousins is the size of its molecules.
Mandelic acid's molecules are larger than any of the other alpha hydroxy acids used in skincare.


Mandelic acid's molecules are twice the size compared to glycolic acid.
Mandelic acid's larger molecules penetrate the skin much more slowly than smaller molecule counterparts.
This slow absorption means Mandelic acid is much more gentle and much less likely to cause skin irritation.
Just because mandelic acid is slow-absorbing doesn't mean that you'll feel Mandelic acid "sitting" on your skin.


It just means Mandelic acid will penetrate the skin's layers at a much slower pace than glycolic acid will, for instance.
The slow absorption is all happening at the molecular level.
The biggest benefit of mandelic acid is Mandelic acid's gentle nature.
Other AHAs and topical retinoids may work faster, and generally be more effective, but not all skin types can handle these products.


For more sensitive skin types, mandelic acid is a very good option.
Derived from the bitter almond, Mandelic acid is a gentle yet highly effective alpha hydroxy acid (AHA).
Mandelic Acid is an alpha hydroxy acid, or AHA, derived from bitter almonds but Mandelic acid is more gentle than some other AHAs like Lactic and

Glycolic because its molecules are much bigger, meaning they don’t penetrate the skin quite as quickly or as deeply.
AHAs work by exfoliating the layers of dead skin away by breaking the bonds between cells to reveal a clearer and brighter complexion while improving the skin’s overall tone and texture.


If you’re new to acids and don’t want to deal with any flakiness, redness or irritation, then Mandelic Acid is a great one to start with.
Mandelic Acid is an Alpha Hydroxy Acid (AHA found naturally in almonds).
Mandelic acid is more oil soluble compared with most AHAs so it’s ideal for oily, acne-prone skin.
Mandelic acid is an AHA that comes from bitter almond


An optically active crystalline hydroxy acid C8H8O3 that is obtainable in the levorotatory D-form from amygdalin by hydrolysis but is usually made in the racemic form by reaction of benzaldehyde with hydrocyanic acid and then hydrochloric acid and that is used chiefly in the form of its salts as a bacteriostatic agent for genitourinary tract infections.
Mandelic acid is a type of alpha hydroxy acid (AHA) that’s derived from bitter almonds.
Mandelic acid is a powerful ingredient which can help to supercharge your skincare routine when it needs a boost.
Like other types of AHAs Mandelic acid works by exfoliating the skin.


Mandelic acid is gentler compared to glycolic acid because its molecule size is twice as big, so Mandelic acid takes longer to penetrate the skin.
Finally, like all acids, mandelic has the tendency to make skin sensitive to UVA rays, so wearing an SPF during the day is non-negotiable if you want to keep hold of your glow.
Mandelic acid also especially good for those with darker skintones who are genetically prone to pigmentation and melasma.
Mandelic acid works really well when paired with vitamin C.


Encapsulated retinaldehyde are also a good match, along with peptides and antioxidants.
Mandelic acid belongs to the alpha hydroxy acid (AHA) family.
Extracted from bitter almonds, this naturally derived acid has been shown to improve all skin types from oily and acne prone to mature, sensitive and everything in between.
Best known for its exfoliation capability, mandelic acid is gentler than its fellow AHAs, glycolic and lactic acids.


Mandelic acid is soluble which allows it to not only exfoliate the surface of your skin but work deeper down on your pores as well.
The molecular weight of mandelic acid is 152.1 daltons which is larger than other alpha hydroxy acids (glycolic acid is 76.0 daltons, for example).
This larger size allows mandelic acid to penetrate the skin more slowly which in turn makes it very gentle and suitable for all skin types including the most sensitive skin.


You don't need a concentration of more than 10%, because then you would simply be achieving an indirect peeling strength that is more easily offered through lower percentages of glycolic acid.
Mandelic acid is an alpha hydroxyl acid derived from bitter almonds but is less irritating to the skin compared to Glycolic acid.
Mandelic acid has a larger molecular weight that sits on the surface of the skin and gently exfoliates without irritating the skin.


Mandelic acid helps to exfoliate dead skin cells and promotes skin cell turnover, lightens blemishes and dark spots, fights skin ageing and results in brighter, even-toned and healthier, radiant skin.
Additional key ingredients like Panthenol, Centella Asiatica Extract and Beta-Glucan soothes and moisturizes the skin even after exfoliation.


Mandelic Acid is a water-soluble alpha hydroxy acid derived from bitter almonds.
This gentle exfoliant is rich in antioxidants and has antibacterial properties.
Mandelic Acid helps even out textured skin from hyperpigmentation, and fights against free-radical damage.
Mandelic acid is a powerful ally and the best acid for acne.


Mandelic Acid works wonderfully bringing peace to problematic skin.
This alpha-hydroxy-acid, Mandelic Acid, is a larger molecule than its close relative, glycolic acid.
Due to the larger molecule size, Mandelic Acid is drastically less irritative to the skin.
Mandelic acid is a lipophilic alpha hydroxyacid (AHA) with known antibacterial properties.


Mandelic acid is an increasingly popular alpha hydroxy acid derived from the hydrolysis of an extract of bitter almonds.
Mandelic acid is naturally derived from bitter almonds.
Mandelic acid is an alpha hydroxy acid (AHA) that is used to exfoliate the skin.
Mandelic acid designed to treat acne, hyperpigmentation, and fight the signs of ageing.


If you’re a newbie to the world of exfoliants Mandelic acid’s probably the best one to try first since it is the most gentle of all the alpha-hydroxy acids.
The biggest benefit of mandelic acid is its gentle nature.
Other AHAs and topical Retinoids may work faster but not all skin types and skin conditions can handle these products.
Remember that in order to achieve great results you need to be consistent with your skin care routine and most of all patience.



USES and APPLICATIONS of MANDELIC ACID:
Mandelic acid has a long history of use in the medical community as an antibacterial, particularly in the treatment of urinary tract infections.
Mandelic acid has also been used as an oral antibiotic, and as a component of chemical face peels analogous to other alpha hydroxy acids.
The drugs cyclandelate and homatropine are esters of mandelic acid.
Mandelic Acid is a versatile AHA that targets visible redness, blemishes, uneven skin tone and fine lines & wrinkles.


AHAs are natural and synthetic ingredients that provide skin care benefits ranging from exfoliation to increasing hydration and firmness.
Mandelic acid has a long history of use in the medical community as an antibacterial agent, particularly in the treatment of urinary tract infections.
Mandelic acid has also been used as an oral antibiotic.
Lately, mandelic acid has gained popularity as a topical skin care treatment for adult acne.


Mandelic acid is also used as an alternative to glycolic acid in skin care products.
Mandelic acid is a larger molecule than glycolic acid, which makes it better tolerated on the skin.
Mandelic acid is also advantageous in that it possesses antibacterial properties, whereas glycolic acid does not.
Mandelic acid is used as a skin care modality.


Dermatologists now suggest mandelic acid as an appropriate treatment for a wide variety of skin pathologies, from acne to wrinkles.
Mandelic acid is especially good in the treatment of adult acne because Mandelic acid addresses both of these concerns.
Mandelic acid is also recommended as a prelaser and postlaser resurfacing treatment, reducing the amount and length of irritation.
Mandelic acid peels are commercialized nowadays as gels with a specific viscosity, which make them user friendly for beginners.


Mandelic acid is a large-molecule alpha-hydroxy acid with slow epidermal penetration.
Similar to the other alpha-hydroxy acids described, Mandelic acid decreases corneocyte adhesion and is keratolytic.
Aside from acne treatment,Mandelic acid is often used for skin rejuvenation and lightening.
Mandelic acid is used as an ingredient in cosmetics and drug products applied topically.


Mandelic Acid is an aromatic alpha hydroxy acid used in the treatment of urinary tract infections and as an oral antibiotic.
Mandelic acid is a useful precursor to various drugs.
Vivant’s synergistic formulations feature Mandelic Acid in a range of transformative products for dramatic difference.
Mandelic acid can assist with brightening the skin, lightening melasma, and fading dark spots.


Mandelic acid should be applied as part of your nighttime skincare routine, after cleansing and before moisturizing.
Mandelic acid is beneficial for those with oily skin, as it helps to control excess sebum production.
Because of its smaller molecular size (compared to other chemical exfoliants), mandelic acid does not absorb as deeply and is, therefore, more suited for sensitive skin types.


There is evidence to suggest mandelic acid peels are effective and safe to treat skin conditions, such as acne.
Mandelic acid is an acidic chemical that has become popular for its use in skin cosmetics.
Mandelic acid chemical peels are common forms of single-ingredient chemical peels, alongside glycolic acid, glycolic acid, and lactic acid chemical peels.


The goal of Mandelic acid is to remove a predictable, uniform thickness of damaged skin.
A chemical peel can help with: inflammatory and noninflammatory acne lesions, scarring, rosacea, wrinkles.
Mandelic acid can be helpful for some people with skin conditions.
Mandelic acid can increase skin firmness and elasticity.


Mandelic acid chemical peels may be useful for: dyspigmentation — an abnormality in the skin pigment; skin redness — erythema
oily skin or excess sebum.
Best for oily, normal, dry, or combination skin types, this product works to balance excess oil, refine pores, and even tone and texture and can be used both morning and night.


If you have super-sensitive skin, a mandelic peel might be the best option for you.
Mandelic acid has shown some benefits for brightening the skin as well, so it can help support a regimen to clear photo damage.
Mandelic acid is generally used as a pharmaceutical component due to its analgesic, antirheumatic, and spasmolytic effects.
Mandelic acid is an exfoliant, antimicrobial/antibacterial


Used in Agriculture & Animal Care, CASE - Coatings, Adhesives, Sealants & Elastomers, Chemical & Materials Manufacturing, Food & Beverage, Personal Care & Pharmaceutical, Surface Treatment - Fluids, Lubricants & Metalworking
Mandelic acid can gently lift off dead surface skin cells and make the skin more smooth and even
Mandelic acid has antibacterial properties


Mandelic acid is promising against acne and post inflammatory hyperpigmentation
Mandelic acid is antimicrobial, regulates sebum production to help prevent breakouts, clears pores, exfoliates, and stimulates cell turnover.
Mandelic acid is used to treat hyperpigmentation and melasma.
Mandelic acid works by breaking up discoloration produced by sun exposure, post-inflammatory hyperpigmentation (PIH), and hormones.


As an exfoliant, Mandelic Acid helps diminish fine lines and wrinkles, reducing the visible effects of photoaging and improving skin texture.
Because of its larger molecule size, Mandelic Acid penetrates the epidermis more gently, making it an ideal AHA for sensitive skin types.
Mandelic Acid is used on people with excess sebum due to its oil targeting properties, making it beneficial in the treatment of oily skin and acne-prone skin.


Mandelic Acid is ideal for oily and acne-prone skin.
Mandelic acid is also naturally anti-fungal, anti-inflammatory, anti-bacterial, and suppresses overactive melanin production.
Mandelic Acid is also amazing for aging concerns, as it speeds up cell turnover.
In turn, this process brings young skin cells to the surface faster.


Mandelic acid increases collagen production in the skin, leading to plumper, healthier skin.
Mandelic acid accelerates the biological process of peeling the skin and helps control skin care concerns.
The molecular structure of Mandelic acid is larger than alternative alpha hydroxy acids such as glycolic acid, meaning it takes longer to penetrate into the skin’s surface and is much less irritating.


The notable difference between Glycolic acid and Mandelic acid based products is the lack of skin irritation and erythema that often accompany skin treatments with Mandelic acid.
This is one of many positive differences between the two different forms of acid, making Mandelic acid a safer medium to work with both professionally and when recommended for at home use.
Mandelic acid is a medicinally important chiral molecule that is widely used as a vital component in antibiotics, antiseptics and cosmetics.


Mandelic acid has been studied extensively for its uses in treating common skin problems such as photo-ageing, irregular pigmentation and acne.
Mandelic acid is a fruit acid that exfoliates the skin and removes dead skin cells.
Mandelic acid is also antimicrobial, meaning it inhibits the growth of bacteria on your skin, which helps prevent acne.
Mandelic acid is often used as an alternative to salicylic acid because it can be less irritating to the skin and more effective at treating blemishes.


Mandelic acid works by dissolving the “glue” that holds dead skin cells together.
This allows them to shed more easily, which means that your face will feel smoother after treatment.
Mandelic acid also helps to stimulate collagen production, which results in younger-looking skin over time.
Mandelic acid is safely used by a wide range of skin types.


-Acne:
Mandelic Acid is antibacterial and this means it’s perfect for treating existing acne and preventing future breakouts.
Because it’s also oil-soluble, Mandelic acid penetrates the skin’s surface to help regulate sebum production and keeps the pores free of dead skin cells that can all lead to breakouts and excess oil.


-Wrinkles and fine lines:
This multitasking ingredient works to accelerate cell turnover by dissolving the bonds that hold the cells together, helping to slough away dead skin on the surface that can lead to dullness and premature signs of ageing.
Mandelic acid also works hard to boost the production of collagen and elastin, the two ingredients which naturally occur in the skin and are responsible for keeping it smooth and plump.


-Pigmentation:
Breakouts can leave behind dark marks and scars that can be tricky to get rid of but, fortunately, Mandelic Acid is a key player when it comes to discoloration and pigmentation.
Mandelic acid is so effective at doing this that it’s often found in professional chemical peels.
Mandelic acid works by dissolving the dead skin cells at the surface to fade the appearance of marks until they completely disappear.
Mandelic acid can also reduce the severity of melasma, resulting in a clear, more even complexion.


-Dullness:
Dead skin accumulates over time and clogs the pores causing the skin to look dull and lacklustre.
Because of its ability to dissolve these dead cells, Mandelic Acid will leave your skin looking brighter, more radiant and even when used regularly.


-Acne:
Skin oils, bacteria, dead skin cells, and inflammation can trigger acne.
Using skin care products containing mandelic acid help regulate sebum production, unclog pores, and reduce inflammation.
This can result in fewer acne breakouts.
A chemical peel with 45 percent mandelic acid was equally effective as a chemical peel with 30 percent salicylic acid in mild to moderate acne.
Mandelic acid may have an edge over salicylic acid when treating inflammatory acne (papules and pustules), and mandelic acid may also have fewer adverse effects.


-Skin texture::
The exfoliating action of mandelic acid removes dead skin cells, which may leave your skin firmer and smoother.


-Hyperpigmentation:
Mandelic acid may also have some lightening properties for dark spots, such as those seen in melasma.
Mandelic acid may reduce hyperpigmentation in melasma by as much as 50 percent in about 4 weeks.


-Wrinkles and fine lines:
Chemical peels with mandelic acid may help stimulate collagen production, which tends to decrease with age.
This can help soften the appearance of wrinkles and fine lines, resulting in a more vibrant, youthful appearance.



GENTLE ENOUGH FOR EVERYDAY USE, MANDELIC ACID:
*Refines skin texture and tone
*Reduces the appearance of fine lines and wrinkles
*Helps unclog pores and remove blackheads
*Inhibits dark spots and helps uneven skin tone
Mandelic acid can be used as a daily treatment that promotes cellular turnover, which addresses photo-aging, fine lines, acne, dark spots and overall skin texture.



TIPS FOR USING MANDELIC ACID:
Whether you're going with OTC products or pro peels, there are a few things you can do to get the most from your treatments.
Start off with a low concentration and increase over time.
Jumping in with a high-percentage product or peel can cause irritation, even with generally gentle mandelic acid.

Start with a lower percentage and work your way up slowly to allow your skin to get used to the AHA.
Don't go with high-strength peels for at-home use.
Through online retailers, you can now get high-percentage mandelic acid peels delivered to your door.

But just because you can buy a high-strength peel doesn't mean you should.
The higher the percentage of mandelic acid in your peel, the greater the risk of side effects.
You can still get good results with lower-strength peels if used consistently.
Leave the stronger peels for those who have been trained.

Wear sunscreen daily.
Any AHA peel or product can make your skin more sensitive to the sun.
When you're using any type of exfoliating product or having peels done, you should use SPF 30 or higher every day to protect your skin from the damaging effects of the sun.



MANDELIC ACID VS. GLYCOLIC ACID:
Glycolic acid is another AHA that's widely used in many skin care products.
It's derived from sugar cane and is effective at exfoliating skin, reducing fine lines, and preventing acne.
Glycolic has the smallest molecular weight amongst all the AHAs, and thus penetrates the skin more easily.
For this reason, glycolic acid may be more irritating to the skin than mandelic acid.

Due to Mandelic acid's larger molecular structure, mandelic acid doesn't penetrate the skin as deeply as glycolic acid, so Mandelic acid is gentler on the skin.
Mandelic acid has been found to be effective for inflammatory acne and some forms of hyperpigmentation, as well as treating sun damage and evening out pigmentation.

The key difference here is molecule size.
While glycolic acid and mandelic acid are both chemical exfoliants, the molecular size of glycolic acid is much smaller, which means it penetrates the skin more deeply and, subsequently, can produce a more dramatic effect.
Both mandelic acid and glycolic acid are alpha-hydroxy acids.

However, mandelic is derived from almonds while glycolic is derived from sugar cane (or a couple of other sources).
Mandelic is oil soluble, glycolic is not.
Perfect for sensitive skin types, The Ordinary's Mandelic Acid works to target hyperpigmentation, uneven skin tone, and fine lines.
In addition to the brand being wallet-friendly, its products are also cruelty-free and vegan.

Mandelic acid can be used to treat three major skin concerns: signs of ageing, acne and enlarged pores, as well as pigmentation that is the result of excess sun exposure, acne scarring, taking hormonal contraceptives and pregnancy.
Mandelic acid targets these concerns by speeding up cell turnover that slows with age.
Very gently Mandelic acid dissolves the tiny glue-like bonds that bind skin cells together, helping to remove dead skin build on the surface.

Mandelic acid also strengthens collagen, one of the building blocks of the skin’s support network that gives skin its bounce.
Widely used as an anti-aging treatment, mandelic acid provides a multitude of benefits ranging from lightening discoloration and signs of hyperpigmentation to softening lines and wrinkles and treating acne.

When added to skin care, mandelic acid accelerates cell turnover to strengthen collagen and reverse damage caused from aging and sun exposure.
Mandelic acid also helps to regulate sebum production to prevent future blemishes.
Mandelic acid is anti-septic and antibacterial qualities also help reduce inflammation, lighten pigmentation, improve texture and tone

Mandelic acid has been found useful to improve various skin conditions including UV-driven lentigenes, darkening of skin seen with melasma, inflammatory acne, wrinkles, and fine lines.
Mandelic Acid peel for the treatment of moderate skin aging, superficial pigmentations, and open pores.
Mandelic acid actives renew the epidermis and even the skin tone.
The action of the Mandelic acid helps to clear and control mild inflammatory acne.

Mandelic acid is an alpha hydroxy acid (AHA) that is used to exfoliate the skin.
Mandelic acid is used to treat acne, hyperpigmentation, and aging skin.
Mandelic acid is used in over-the-counter skincare products and in professional chemical peels.
Mandelic acid is the most gentle of all the alpha-hydroxy acids, so it can be safely used by a wide range of skin types.



BENEFITS OF MANDELIC ACID:
*Gently Exfoliates
*Provides Superficial Peeling
*Clarifies Pores
*Lightens Hyperpigmentation
*Reduces Fine Lines
*Gentle on the skin:
One main benefit of mandelic acid is that Mandelic acid may be more gentle on the skin compared to other AHAs.
This makes Mandelic acid an ideal choice for those with sensitive skin.
This gentleness seems to be due to mandelic acid being one of the largest AHAs, and as a result, Mandelic acid penetrates the skin at a slower rate.

*Accelerates cell turnover:
Mandelic acid accelerates cell turnover and functions as a powerful exfoliate to remove dead skin cells.
For this reason, mandelic acid is found in some chemical peels.

*Promotes collagen production
Mandelic acid also improves skin appearance because Mandelic acid promotes collagen production, which is the main protein found in skin and connective tissue.
Results from using mandelic acid vary from person to person, but some people anecdotally notice a difference in their complexion and appearance after a couple of weeks.

*Exfoliates:
Mandelic acid is a chemical exfoliant, meaning it removes layers of older skin cells through a reaction with the skin (rather than exfoliating via abrasive scrubs).
*Promotes cell turnover:
By releasing skin cells attached to the surface of the skin, mandelic acid works to increase cell turnover, reducing the appearance of skin damage or acne.

*Brightens skin:
Exfoliated skin appears brighter and mandelic acid goes a step further, strengthening the skin so it stays bright with continued use.
*Reduces hyperpigmentation:
Increased cell turnover and exfoliating properties mean the acid reduces the look of dark marks and sun damage.

*Wrinkles and fine lines:
Mandelic acid is a go-to anti-ageing ingredient in the world of skincare.
Mandelic acid works to accelerate cell turnover by dissolving the tiny bonds that hold skin cells together, helping to remove dead skin on the surface that can lead to dull complexions, as well as fine lines.
Mandelic acid also strengthens collagen, one of the building blocks of the skin’s support network that gives it youthful firmness.

*Hyperpigmentation and discolouration:
Malesma is a common skin condition in which light to dark brown or greyish pigmentation develops on the face.
Mandelic acid has been shown to reduce melasma by as much as 50% in four weeks, resulting in a more evenly coloured complexion.

*Acne:
Mandelic acid’s antibacterial properties are extremely helpful in treating acne.
Mandelic acid also helps to regulate sebum production and in turn decrease the occurrence of breakouts.
Mandelic acid has even been shown to benefit those who suffer from cystic acne.
Using mandelic acid regularly can help improve many skin issues.

*Brightens Your Complexion:
As an exfoliator, mandelic acid refines your complexion.
Exfoliated skin feels softer and smoother, and looks brighter.
*Fades Hyperpigmentation and Melasma:
Mandelic acid can help fade hyperpigmentation of all types: sun spots or age spots, freckles, post-inflammatory hyperpigmentation, and melasma.

*Helps Improve Acne Blemishes and Marks:
Although Mandelic acid is not used alone to treat acne, it can be incorporated into an acne treatment routine to help clear pores and reduce comedones.
Mandelic acid has antibacterial effects, so it can be especially helpful in reducing inflammatory acne.
Mandelic acid can also help fade dark marks left by pimples.

*Softens Signs of Aging:
Mandelic acid is also a gentle treatment for aging skin.
Mandelic acid can help soften fine lines, and long-term use may help with firmness and elasticity.
Mandelic acid won't really reduce expression lines, though, such as the lines between your eyebrows.
But if your skin is on the dry side, mandelic acid can help your dry skin produce more of its own sebum or natural oil.

*Gentle Exfoliator for All Skin Types:
Mandelic acid is the gentlest of all alpha hydroxy acids so Mandelic acid can be used by a wider array of skin types, including those with sensitive skin and rosacea.
Even people who can't use other AHAs can often use mandelic acid without any irritation.
Mandelic acid is especially good for skin that is prone to discoloration because Mandelic acid won't trigger inflammation and hyperpigmentation as other AHAs can.

*For darker skin types, particularly where pigmentation from other AHAs may occur.
*Antibacterial with benefits for the reduction in the appearance of skin blemishes.
*Skin exfoliation benefits, which promote a renewed skin appearance.
*Less irritating than conventional AHAs.
*Stimulates new skin cells for long-term health
*Exfoliates dead skin cells for immediate clarity

*Promotes younger-looking skin by diminishing wrinkles
*Improves skin elasticity, hydration, and texture
*Reduces the appearance of pore size and prevents breakouts
*Menthol and Cucumber Flower Extract soothes and cools
*Mandelic acid has a wide range of benefits.

*Mandelic acid helps regulate oil production and can be effective against acne and acne scars.
*When applied to your skin, mandelic acid exfoliates the top layer, encouraging new skin cells to come to the surface for a fresh and smooth appearance.
*Thirdly, mandelic acid exfoliates the upper skin layer without causing inflammation or irritation on your skin, and it can promote collagen growth.
*Finally, mandelic acid fights hyperpigmentation caused by age spots, sun damage, and melasma.
*Overall, there are plenty of reasons to use citric acid daily on your skin.



WHAT ARE THE SKIN BENEFITS OF USING MANDELIC ACID?
By removing the build-up of dead skin cells it thins out the very top layer of the skin so that it becomes smoother is able to reflect the light better.
As a result, you can expect improvement in skin texture and a brighter, more luminous complexion.
It’s even been shown to reduce melasma by as much as 50 percent in four weeks.
Acne suffers can also look forward to a reduction in breakouts. Mandelic acid has antibacterial properties which help to regulate sebum production.
It’s even been shown to benefit those cystic acne sufferers.



HOW DOES MANDELIC ACID BENEFIT SKIN?
Mandelic acid's powerful antibacterial properties team up with its gentle exfoliating, cell-turnover-activating abilities team up to defeat acne, dull skin, uneven texture, hyperpigmentation, and fine lines and wrinkles.
Mandelic acid does the latter by boosting collagen production.
After about one to three weeks of use, mandelic acid is making your skin smoother, brighter, plumper, and clearer, she adds.
Mandelic acid sucks up acne-causing bacteria and oil clogging up your pores, as well as dead, discolored skin cells on the surface of your skin — leaving your floors, I mean complexion, cleaner and sparklier than ever.



THINGS TO CONSIDER AFTER MANDELIC ACID TREATMENT:
After your mandelic acid peel treatment, you’ll want to take some time to consider your next steps in order to ensure the best results possible.
Here are three things you should consider after your mandelic acid peel treatment:

1. Don’t Use Any Other Peels While Your Skin Is Healing:
Some people like to use weekly glycolic or salicylic acid treatments after their mandelic acid peel to help speed the recovery process, but I personally don’t recommend it.
Use an only moisturizer for 3-4 days after your treatment, and then slowly introduce other products back into your routine one at a time (like toner and serum) until you’re back up to full strength again.

2. Don’t Pick at Your Skin! :
This is especially important right after the peel has been applied.
Because that’s when it’s most vulnerable to picking off any dead skin cells that are ready to shed anyway.
Picking at your face can cause scarring and damage your skin’s natural barrier function — which is exactly what we want our peels doing for us!

3. Avoid Products with Alcohol and Retinol:
After treatment, avoid products that contain alcohol or retinol (vitamin A).
These ingredients can cause irritation and increase redness on your skin, which could lead to breakouts and hyperpigmentation (dark spots).
The same goes for products that have high levels of glycolic acid; these are also known as alpha-hydroxy acids (AHAs) and can cause sensitivity after this type of procedure.

4. Moisturize Your Skin Regularly:
A properly moisturized skin surface helps prevent dryness and flaking after any chemical peel procedure.
Mandelic acid peels can cause slight irritation of the skin’s surface due to their mild exfoliating properties.
To avoid this irritation from becoming problematic, make sure you use a moisturizing cream regularly after your treatment.

5. Avoid Tanning Beds:
If you want to maintain your results from this procedure, avoid tanning beds at all costs!
Tanning beds are known to accelerate aging and cause damage to the DNA within cells called melanocytes, which produce melanin — the pigment responsible for giving skin its coloration.



ISOLATION, SYNTHESIS, OCCURRENCE OF MANDELIC ACID:
Mandelic acid was discovered in 1831 by the German pharmacist Ferdinand Ludwig Winckler (1801–1868) while heating amygdalin, an extract of bitter almonds, with diluted hydrochloric acid.
The name is derived from the German "Mandel" for "almond".
Mandelic acid is usually prepared by the acid-catalysed hydrolysis of mandelonitrile, which is the cyanohydrin of benzaldehyde.

Mandelic acid can also be prepared by reacting benzaldehyde with sodium bisulfite to give the corresponding adduct, forming mandelonitrile with sodium cyanide.
Alternative, Mandelic acid can be prepared by base hydrolysis of phenylchloroacetic acid as well as dibromacetophenone.
Mandelic acid also arises by heating phenylglyoxal with alkalis.



BIOSYNTHESIS OF MANDELIC ACID:
Mandelic acid is a substrate or product of several biochemical processes called the mandelate pathway.
Mandelic acid interconverts the two enantiomers via a pathway that involves cleavage of the alpha-CH bond.
Mandelate dehydrogenase is yet another enzyme on this pathway.

Mandelate also arises from trans-cinnamate via phenylacetic acid, which is hydroxylated.Phenylpyruvic acid is another precursor to mandelic acid.
Derivatives of mandelic acid are formed as a result of metabolism of adrenaline and noradrenaline by monoamine oxidase and catechol-O-methyl transferase.

The biotechnological production of 4-hydroxy-mandelic acid and mandelic acid on the basis of glucose was demonstrated with a genetically modified yeast Saccharomyces cerevisiae, in which the hydroxymandelate synthase naturally occurring in the bacterium Amycolatopsis was incorporated into a wild-type strain of yeast, partially altered by the exchange of a gene sequence and expressed.
Mandelic acid also arises from the biodegradation of styrene and ethylbenzene, as detected in urine.



TYPES OF MANDELIC ACID:
Not all mandelic acid products are created equal.
If you’re looking for an effective treatment for acne or folliculitis, make sure you choose a product containing L-mandelic acid.
Regular mandelic acid, while still effective, is less concentrated and therefore less potent.
L-mandelic acid is the chirally correct version of the molecule and creates all of the skin-positive effects we love mandelic acid for!



HOW DOES MANDELIC ACID WORK?
Due to the natural process of cell turnover, dead skin cells accumulate on the surface of the skin.
Without regular exfoliation, dull skin and signs of premature aging will begin to make an appearance.
Mandelic acid works as a potent exfoliator, dissolving the intercellular glue that binds dead skin cells to the surface.
Through a mild exfoliation, mandelic acid removes the top layer of dead epidermal cells.
The result is fresh skin and a dewy glow.



THE BEST ACID FOR DEEP SKIN TONES, MANDELIC ACID:
Mandelic acid is the best choice for deeper skin tones, as it does not trigger an inflammatory response within the skin like other acids (glycolic).
At the same time, Mandelic acid actually inhibits melanin overproduction within the skin, effectively stopping new pigmentation at the source!



6 WAYS MANDELIC ACID CORRECTS YOUR TOP SKIN CONCERNS:
Here are some of the most common skin concerns and how mandelic acid can bring relief:
*Acne prone skin:
The antimicrobial, antibacterial, and anti-inflammatory properties of mandelic acid make it an ideal acne busting ingredient.
Mandelic acid regulates sebum production, removes skin clogging dead skin cells, and reduces blemishes.
You can find our entire glossary of acne treatment tips here.

*Fine lines and wrinkles:
Mandelic acid softens the appearance of fine lines and wrinkles by stimulating the production of collagen and elastin.
These two components of our skin naturally decline with age.
You’ll see continued, ongoing improvement with consistent use of mandelic skincare products.

*Melasma and hyperpigmentation:
Mandelic acid can lighten and brighten skin, fade unwanted sun spots, banish acne scars, and minimize age spots.
With continued use, you’ll see damage from aging and sun exposure slowly reverse.
Mandelic acid also reduces brown spots from melasma by as much as 50% in only four weeks!

*Enlarged pores:
Experience immediate pore-refining benefits as mandelic acid works to exfoliate, unclog, and reduce the appearance of large pores.
The anti-inflammatory properties of mandelic acid further serve to minimize facial pore size.

*Folliculitis:
Fungal infections of the hair follicles is also easily cleared with Mandelic Acid.
Those who deal with shaving bumps will see great results from using a mandelic cleanser.

*Rosacea:
Mandelic acid is both safe and beneficial for those suffering from redness and rosacea, an inflammatory skin disease characterized by burning, stinging, sensitive skin.
The calming and exfoliating properties of mandelic acid make it a powerful ally for healing rosacea.



WHAT PERCENTAGE OF MANDELIC ACID IS EFFECTIVE?
Mandelic acid is an alpha hydroxy acid that is used in cosmetic surgery.
Mandelic acid is a naturally occurring substance that is derived from bitter almonds.
Mandelic acid has been used as a skin-bleaching agent for over centuries, and it is still used today for this purpose.

Mandelic acid works by reducing hyperpigmentation and hyperkeratosis (thickening of the skin).
Mandelic acid also increases collagen production and elastin which makes the skin smoother.
Mandelic acid has been shown to be effective in treating melasma, acne, and psoriasis.

Mandelic acid also reduces fine lines and wrinkles by removing dead skin cells from the surface of the skin.
The success rate of mandelic acid depends on what kind of treatment you’re having. For example:
For wrinkles — 15% – 20% reduction in fine lines after four months of twice-weekly treatment.
For acne — 80% reduction in acne breakouts after three months of twice-weekly treatment.



WHEN DO PEOPLE NEED TO USE MANDELIC ACID TREATMENT?
-Skin Types:
All types of skin can benefit from mandelic acid treatment.
However, since Mandelic acid is an exfoliant, oily or acne-prone skin types may require more frequent use at lower concentrations.
When selecting your mandelic acid skincare product, consider whether you have dry or sensitive skin that reacts poorly to exfoliants (products or procedures).
If so, look for formulations with lower concentrations of 10% or less.

-Acne:
Mandelic acid has been shown to be effective in reducing sebum production by up to 40%.
This makes Mandelic acid an ideal choice for those with oily or acne-prone skin who are looking for something other than benzoyl peroxide or salicylic acids which can cause photosensitivity reactions.



HOW LONG DOES MANDELIC ACID TAKE TO WORK?
Mandelic acid is a chemical exfoliant that you can find in skincare products like cleansers and toners.
Mandelic acid’s one of the gentlest and most effective ingredients for exfoliating the skin.
Mandelic acid works by dissolving dead skin cells and unclogging pores, allowing new skin to grow.

Mandelic acid also helps even out your complexion and reduces acne breakouts.
The exact time it takes for mandelic acid to work depends on how many times you use it and how long you’ve been using it.
Some people see results after just one use, while others need several applications before they start seeing results!
If you’re new to using mandelic acid, start out once or twice a week until your skin adjusts.
Once your skin has acclimated to the product, you can increase its frequency if needed.



HOW TO USE MANDELIC ACID?
Start slowly, using just once per day at first and working up to twice per day if needed.
Percentage of strength is also important.
Never start with a concentration higher than 8%.
Skin always needs time to adjust to new skincare products, particularly exfoliants.

You can expect to experience light flaking for the first few weeks.
So plan to accommodate this by applying extra moisturizer during this time.
Mandelic serum can be applied to clean, dry skin or added to your favorite moisturizer.
Sensitive skin should begin with 5% strength while normal skin can begin with 8% strength.

Most people begin to see a transformation in their skin within two weeks of regular use.
However you should stick to using it for at least 8 weeks for full results.
If you’ve never used an alpha-hydroxy acid product on your skin before or if other acid treatments have caused irritation for you, mandelic acid is a gentle ingredient for you to get started with.



HOW TO ADD MANDELIC ACID TO YOUR SKIN CARE ROUTINE FOR GLOWING SKIN?
Whenever we’re looking for that natural glow we typically turn to exfoliants.
But there’s one you may have been ignoring, one that is loved by those who have sensitive skin.



HOW IS MANDELIC ACID DIFFERENT FROM OTHER AHA'S?
What sets mandelic acid apart from its AHA cousins is the size of its molecules.
Mandelic acid's molecules are larger than any of the other alpha hydroxy acids used in skincare.
Mandelic acid's molecules are twice the size of the ones in glycolic acid.



WHY IS MANDELIC ACID GREAT FOR SENSITIVE SKIN?
Mandelic acid's larger molecules penetrate the skin much more slowly than its smaller molecule counterparts.
This slow absorption means Mandelic acid's much gentler and much less likely to cause skin irritation.



POWERFUL SKIN BENEFITS OF MANDELIC ACID:
The beautiful thing about mandelic acid is the longer you use it, the better results you will see.
Here are the skin benefits you can look forward to:
1. Mandelic acid brightens the skin:
Exfoliated skin feels softer and smoother, and looks brighter.

2. Fades hyperpigmentation and dark spots:
Helps fade hyperpigmentation of all types: sun spots or age spots, freckles, post-inflammatory hyperpigmentation, and melasma.

3. Mandelic acid helps Acne Blemishes and Marks:
Although Mandelic acid's not a stand- alone acne treatment, incorporating it in your skin care routine can help clear pores and reduce comedones.
And because Mandelic acid has antibacterial effects, it’s helpful in reducing inflammatory acne.
Mandelic acid can also improve fade dark spots caused by breakouts.

4. Anti-aging:
Mandelic acid can help soften fine lines, and long-term use may help with firmness and elasticity.
Studies have shown that mandelic acid can help your dry skin produce more of its own sebum or natural oil.

5. Great for sensitive skin:
People who are sensitive to other AHAs can often use mandelic acid without any irritation.
Mandelic acid's especially good for skin that is prone to discoloration because it won't trigger inflammation and hyperpigmentation as other AHAs can.



TIPS FOR USING MANDELIC ACID:
1.Here’s why it’s so effective for achieving clear, radiant skin:
Glycolic - The holy grail of exfoliation; effectively removes the outermost layer of dead skin cells from the complexion, revealing brighter, fresher skin.
Mandelic Acid is a powerful alpha hydroxy acid (AHA) that works to accelerate cell turnover and remove dead skin cells.
Strengthens collagen, assists with evening skin tone, reduces hyperpigmentation and combats acne through its antibacterial properties.

Niacinamide (Vitamin B3) - A highly effective, versatile ingredient that renews and restores moistureless, dehydrated skin by helping improve the natural production of skin strengthening ceramides.
Visibly improves and minimizes enlarged pores, uneven skin tone, fine lines and wrinkles.
It also helps fight free radicals, acne and congestion and reduces redness.

Lepidium Sativum Sprout Extract - High in antioxidants; this ingredient prevents photo-ageing, targets and lightens age/dark spots, prevents their appearance and creates an even skin tone.
Galactoarabinan (GA) - A natural plant collagen that boosts the skins natural ability to retain moisture, improves the skin’s texture and diminishes the appearance of fine lines and wrinkles.

2. Avoid high-strength peels when using it at home.
Leave that to the professionals.
The higher the percentage of mandelic acid in your peel the greater the risk of side effects.
3. As always wear sunscreen daily.
Any AHA peel or product can make your skin more sensitive to the sun.
4. Never combine mandelic acid with prescription topical medications or other types of peels.



ALTERNATIVE PARENTS OF MANDELIC ACID:
*Alpha hydroxy acids and derivatives
*Secondary alcohols
*Monocarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds
*Aromatic alcohols



SUBSTITUENTS OF MANDELIC ACID:
*Hydroxy acid
*Monocyclic benzene moiety
*Alpha-hydroxy acid
*Secondary alcohol
*Monocarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Aromatic alcohol
*Organooxygen compound
*Carbonyl group
*Alcohol
*Aromatic homomonocyclic compound



PHYSICAL and CHEMICAL PROPERTIES of MANDELIC ACID:
Molar mass: 152.149 g·mol−1
Appearance: White crystalline powder
Density: 1.30 g/cm3
Melting point: 119 °C (246 °F; 392 K) optically pure: 132 to 135 °C (270 to 275 °F; 405 to 408 K)
Boiling point: 321.8 °C (611.2 °F; 595.0 K)
Solubility in water: 15.87 g/100 mL
Solubility: soluble in diethyl ether, ethanol, isopropanol
Acidity (pKa): 3.41
Refractive index (nD): 1.5204
Molecular Weight: 152.15
XLogP3: 0.6
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 2
Exact Mass: 152.047344113
Monoisotopic Mass: 152.047344113

Topological Polar Surface Area: 57.5 Ų
Heavy Atom Count: 11
Formal Charge: 0
Complexity: 138
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Appearance Form: solid
Color: white
Odor: weakly aromatic
Odor Threshold: No data available

pH: 2,3 at 10 g/l
Melting point/range: 119 - 121 °C - lit.
Initial boiling point and boiling range: 255 - 340 °C at ca.1.013 hPa
Flash point: Not applicable
Evaporation rate: No data available
Flammability (solid, gas): The product is not flammable.)
Upper/lower flammability or explosive limits: No data available
Vapor pressure: < 0,1 hPa at 25 °C - OECD Test Guideline 104
Vapor density: No data available
Density: 1,31 g/cm3 at 20 °C
Relative density: 1,31 at 20 °C
Water solubility: 139 g/l at 20 °C
Partition coefficient: n-octanol/water: log Pow: 0,5 at 23 °C
Autoignition temperature: does not ignite
Decomposition temperature: No data available



FIRST AID MEASURES of MANDELIC ACID:
-If inhaled
Fresh air.
-In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
-After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
-After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.



ACCIDENTAL RELEASE MEASURES of MANDELIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of MANDELIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MANDELIC ACID:
-Control parameters:
*Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MANDELIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
Light sensitive.
*Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids



STABILITY and REACTIVITY of MANDELIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
Hydroxy(phenyl)acetic acid
2-Hydroxy-2-phenylacetic acid
Mandelic acid
Phenylglycolic acid
α-Hydroxyphenylacetic acid
MANDELIC ACID
dl-Mandelic acid90-64-2
2-hydroxy-2-phenylacetic acid
611-72-3
Phenylglycolic acid
Amygdalic acid
Paramandelic acid
Racemic mandelic acid
Almond acid
Uromaline
p-Mandelic acid
(RS)-Mandelic acid
2-Phenylglycolic acid
Hydroxy(phenyl)acetic acid
Phenylhydroxyacetic acid
Glycolic acid, phenyl-
alpha-Hydroxyphenylacetic acid
Kyselina mandlova
2-Phenyl-2-hydroxyacetic acid
DL-Hydroxy(phenyl)acetic acid
(+/-)-mandelic acid
2-hydroxy-2-phenyl-acetic acid
Benzeneacetic acid, alpha-hydroxy-
NSC 7925
Benzeneacetic acid, .alpha.-hydroxy-
(+/-)-alpha-Hydroxyphenylacetic acid
.alpha.-Hydroxyphenylacetic acid
alpha-Hydroxy-alpha-toluic acid
NSC-7925
NH496X0UJX
CHEBI:35825
(+-)-alpha-Hydroxybenzeneacetic acid
alpha-Hydroxybenzeneacetic acid
.alpha.-Hydroxy-.alpha.-toluic acid
.alpha.-Toluic acid, .alpha.-hydroxy-
Ammonium mandelate
(+)-Mandelate, XXI
Acido mandelico
(+-)-Mandelic acid
Benzeneacetic acid, alpha-hydroxy-, homopolymer
32518-00-6
Benzeneacetic acid, .alpha.-hydroxy-, (.+/-.)-
mandelic-acid
2-Hydroy-2-phenylacetic acid
Mandelic acid
DL-Amygdalic Acid
DL-Mandelicacid
DL-2-Hydroxy-2-phenylacetic acid
Kyselina mandlova [Czech]
(+-)-2-Hydroxy-2-phenylethanoic acid
alpha-Toluic acid, alpha-hydroxy-
(+-)-alpha-Hydroxyphenylacetic acid
EINECS 202-007-6
EINECS 210-277-1
UNII-NH496X0UJX
2-Hydroxy-2-phenylethanoic acid
acidomandelico
alpha-Hydroxybenzeneacetic acid, (+-)-
AI3-06293
Kyselina 2-fenyl-2-hydroxyethanova [Czech]
MFCD00004495
MFCD00064251
Benzoglycolic acid
Phenylacetic acid, alpha-hydroxy-
NCGC00166022-01
l(+)mandelic acid
(+) mandelic acid
(+)-mandelic acid
PPCM
SAMMA
hyroxyphenylacetic acid
Pregabalin Impurity C
(+/-)-alpha-Hydroxybenzeneacetic acid
Mandelic acid, 99%
(-)-Mandelate, XX
hydroxyphenyl acetic acid
81432-25-9
Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)-
Pregabalin EP Impurity C
WLN: QYR&VQ
hydroxy-phenyl-acetic acid
Mandelic acid, >=99%
DL-Mandelic acid, 99%
MANDELIC ACID
SCHEMBL1050
(.+/-.)-Mandelic acid
CHEMBL1609
(+)-Phenylhydroxyacetic acid
(?)-Phenylhydroxyacetic acid
2-Hydroxy-2-phenylaceticacid
MLS001074208
.alpha.-Phenylhydroxyacetic acid
DTXSID6023234
BDBM92715
NSC7925
Mandelic acid condensation polymer
2-oxidanyl-2-phenyl-ethanoic acid
HMS2230F19
HMS3371M20
HMS3373A03
(2rs)-hydroxy(phenyl)ethanoic acid
BBL028097
MFCD00064250
s3363
STL283951
AKOS000118795
AKOS016050628
CS-W016307
DB13218
HY-W015591
KS-1423
NCGC00166023-01
NCGC00166269-01
(.+/-.)-alpha-Hydroxybenzeneacetic acid
AC-12228
SMR000653543
SY001645
SY001670
DB-016128
DB-016158
DS-000887
AM20060842
FT-0600010
FT-0601504
FT-0625487
FT-0628148
M0038
Benzeneacetic acid, .alpha.-hydroxy-, ( )-
Benzeneacetic acid, .alpha.-hydroxy-, (S)-
EN300-19482
PHENYLACETIC ACID, .ALPHA.--HYDROXY-
A19434
DL-Mandelic acid, analytical reference material
MLS-0090887.0001
A833072
AE-562/40233036
Q412293
(2RS)-2-Hydroxy-2-phenylacetic Acid (Mandelic Acid)
GLYCOPYRRONIUM BROMIDE IMPURITY C
Mandelic Acid ((2RS)-2-Hydroxy-2-phenylacetic Acid)
14A53E4A-8315-42A7-9D60-DE06CCBB1AF9
F2191-0202
HOMATROPINE HYDROBROMIDE IMPURITY C
Z104473974
HOMATROPINE METHYLBROMIDE IMPURITY C
Mandelic acid, United States Pharmacopeia (USP)
Mandelic acid
(2RS)-2-Hydroxy-2-phenylacetic acid
?-Hydroxy-Benzeneacetic acid





mangane sulfate
MANGANE SULPHATE MONOHYDRATE; manganous(II)sulfate monohydrate; Sulfuric Acid Manganese Salt (1:1) Monohydrate cas no: 10034-96-5
MANGANE SULPHATE MONOHYDRATE
MANGANE SULPHATE MONOHYDRATE Manganese sulphate monohydrate A widely used nutrient that finds a major application as a soil supplement and also as a feed additive for animals. Industry: Agriculture, Animal Feed Application: Feed additives, Fertilisers, Micronutrients, Premixes Synonyms: Manganese(II) sulfate monohydrate; Manganous sulfate monohydrate CAS number: 10034-96-5 Molecular Weight of Mangane sulfate monohydrate :169.02 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Hydrogen Bond Donor Count of Mangane sulfate monohydrate : 1 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Hydrogen Bond Acceptor Count of Mangane sulfate monohydrate : 5 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Rotatable Bond Count of Mangane sulfate monohydrate : 0 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Exact Mass of Mangane sulfate monohydrate : 168.900338 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Monoisotopic Mass of Mangane sulfate monohydrate : 168.900338 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Topological Polar Surface Area of Mangane sulfate monohydrate : 89.6 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Heavy Atom Count of Mangane sulfate monohydrate : 7 Computed by PubChem Formal Charge of Mangane sulfate monohydrate : 0 Computed by PubChem Complexity of Mangane sulfate monohydrate : 62.2 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Isotope Atom Count of Mangane sulfate monohydrate : 0 Computed by PubChem Defined Atom Stereocenter Count of Mangane sulfate monohydrate : 0 Computed by PubChem Undefined Atom Stereocenter Count of Mangane sulfate monohydrate : 0 Computed by PubChem Defined Bond Stereocenter Count of Mangane sulfate monohydrate : 0 Computed by PubChem Undefined Bond Stereocenter Count of Mangane sulfate monohydrate : 0 Computed by PubChem Covalently-Bonded Unit Count of Mangane sulfate monohydrate : 3 Computed by PubChem Compound of Mangane sulfate monohydrate Is Canonicalized Yes Manganese sulfate monohydrate appears as odorless pale red slightly efflorescent crystals or light pink powder. pH (5% solution) 3.7. (NTP, 1992) Manganese sulfate monohydrate is a hydrate that is the monohydrate form of manganese(II) sulfate. It has a role as a nutraceutical. It is a hydrate, a manganese molecular entity and a metal sulfate. It contains a manganese(II) sulfate. Manganese(II) sulfate From Wikipedia, the free encyclopedia Jump to navigationJump to search Manganese(II) sulfate Manganese(II) sulfate close-up.jpg Manganese sulfate monohydrate Manganese(II)-sulfate-tetrahydrate-sample.jpg Manganese(II) sulfate tetrahydrate Names IUPAC name Manganese(II) sulfate Identifiers CAS Number 7785-87-7 check 10034-96-5 (monohydrate) ☒ 10101-68-5 (tetrahydrate) ☒ 3D model (JSmol) Interactive image ChEMBL ChEMBL1200557 ☒ ChemSpider 22984 check ECHA InfoCard 100.029.172 Edit this at Wikidata EC Number 232-089-9 PubChem CID 24580 RTECS number OP1050000 (anhydrous) OP0893500 (tetrahydrate) UNII IGA15S9H40 Properties Chemical formula MnSO4 Molar mass 151.001 g/mol (anhydrous) 169.02 g/mol (monohydrate) 223.07 g/mol (tetrahydrate) 277.11 g/mol (heptahydrate) Appearance white crystals (anhydrous) pale pink solid (hydrates) Density 3.25 g/cm3 (anhydrous) 2.95 g/cm3 (monohydrate) 2.107 g/cm3 (tetrahydrate) Melting point 710 °C (1,310 °F; 983 K) (anhydrous) 27 °C (tetrahydrate) Boiling point 850 °C (1,560 °F; 1,120 K) (anhydrous) Solubility in water 52 g/100 mL (5 °C) 70 g/100 mL (70 °C) Solubility Very slightly soluble in methanol insoluble in ether and ethanol. Magnetic susceptibility (χ) 1.3660×10−2 cm3/mol Structure Crystal structure orthogonal (anhydrous) monoclinic (monohydrate) monoclinic (tetrahydrate) Hazards Safety data sheet ICSC 0290 EU classification (DSD) (outdated) Harmful (Xn) Dangerous for the environment (N) R-phrases (outdated) R48/20/22, R51/53 S-phrases (outdated) (S2), S22, S61 NFPA 704 (fire diamond) NFPA 704 four-colored diamond 011 Related compounds Other cations Chromium(III) sulfate Iron(II) sulfate Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references Manganese sulfate usually refers to the inorganic compound with the formula MnSO4·H2O. This pale pink deliquescent solid is a commercially significant manganese(II) salt. Approximately 260,000 tonnes of manganese sulfate were produced worldwide in 2005. It is the precursor to manganese metal and many other chemical compounds. Manganese-deficient soil is remediated with this salt.[1] Structure Coordination sphere for Mn and S in the monohydrate. The O6 coordination sphere is provided by four separate sulfate groups and a pair of mutually trans bridging aquo ligands.[2] The structure of MnSO4·H2O has been determined by X-ray crystallography. Like many metal sulfates, manganese sulfate forms a variety of hydrates: monohydrate, tetrahydrate, pentahydrate, and heptahydrate. All of these salts dissolve in water to give faintly pink solutions of the aquo complex [Mn(H2O)6]2+. Applications and production Typically, manganese ores are purified by their conversion to manganese(II) sulfate. Treatment of aqueous solutions of the sulfate with sodium carbonate leads to precipitation of manganese carbonate, which can be calcined to give the oxides MnOx. In the laboratory, manganese sulfate can be made by treating manganese dioxide with sulfur dioxide:[3] MnO2 + SO2 + H2O → MnSO4(H2O) It can also be made by mixing potassium permanganate with sodium bisulfate and hydrogen peroxide. Manganese sulfate is a by-product of various industrially significant oxidations that use manganese dioxide, including the manufacture of hydroquinone and anisaldehyde.[1] Electrolysis of manganese sulfate yields manganese dioxide, which is called EMD for electrolytic manganese dioxide. Alternatively oxidation of manganese sulfate with potassium permanganate yields the so-called chemical manganese dioxide (CMD). These materials, especially EMD, are used in dry-cell batteries.[1] Natural occurrence Manganese sulfate minerals are very rare in nature and always occur as hydrates. The monohydrate is called szmikite; tetrahydrate = ilesite; hexahydrate (the most rare) = chvaleticeite; pentahydrate = jōkokuite; heptahydrate = mallardite. Product Information CAS number 10034-96-5 EC index number 025-003-00-4 EC number 232-089-9 Grade Ph Eur,USP,FCC Hill Formula MnO₄S * H₂O Chemical formula MnSO₄ * H₂O Molar Mass 169.02 g/mol HS Code 2833 29 80 PHYSICAL & CHEMICAL INFORMATION Physical State; Appearance PINK HYGROSCOPIC CRYSTALS. Physical dangers Chemical dangers Decomposes on heating. This produces sulfur oxides and manganese oxides. This generates toxic hazard. Formula: MnSO4.H2O Molecular mass: 169.0 Relative density (water = 1): 2.95 Solubility in water, g/100ml: 76.2 (freely soluble) Melting point: 400-450°C EXPOSURE & HEALTH EFFECTS Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Effects of short-term exposure The substance is irritating to the eyes. Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the central nervous system. Animal tests show that this substance possibly causes toxicity to human reproduction or development. Manganese Sulfate Monohydrate is a moderately water and acid soluble Manganese source for uses compatible with sulfates. Sulfate compounds are salts or esters of sulfuric acid formed by replacing one or both of the hydrogens with a metal. Most metal sulfate compounds are readily soluble in water for uses such as water treatment, unlike fluorides and oxides which tend to be insoluble. Organometallic forms are soluble in organic solutions and sometimes in both aqueous and organic solutions. Metallic ions can also be dispersed utilizing suspended or coated nanoparticles and deposited utilizing sputtering targets and evaporation materials for uses such as solar cells and fuel cells. Manganese Sulfate is generally immediately available in most volumes. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Nanoscale elemental powders and suspensions, as alternative high surface area forms, may be considered. We produce to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.
MANGANESE CARBONATE
Manganese Carbonate is a water-insoluble manganese source which occurs naturally in the form of mineral rhodochrosite.
Manganese carbonate can easily be converted to other manganese compounds, such as the oxide by heating.
Manganese carbonate can be widely applied in various fields.

CAS: 598-62-9
MF: CMnO3
MW: 114.95
EINECS: 209-942-9

In the field of agriculture, Manganese Carbonate is commonly used as an additive to plant fertilizers, which is effective to cure the crops with manganese deficiency.
Manganese Carbonate can also be applied in ceramics as a porcelain glaze, glaze colorant and flux and it serves as a catalyst in viscose process.
Besides, Manganese Carbonate has been proved to be used as a hematinic in the field of medicine.
Other applications of manganese carbonate involve in health foods, chemical industry and etc.
Manganese carbonate is a chemical compound that has a structure similar to calcite, with octahedral co-ordination symmetry.

Manganese Carbonate is a carbonate that is insoluble in water and on treatment with acid it gives water soluble salts.
Manganese Carbonate is a widely used material in plant fertilization as an additive that cures the magnesium deficiency in crops.
Manganese carbonate is a compound with the chemical formula MnCO3.
Manganese carbonate occurs naturally as the mineral rhodochrosite but it is typically produced industrially.
Manganese Carbonate is a pale pink, water-insoluble solid.
Approximately 20,000 metric tonnes were produced in 2005.

Manganese carbonate is a compound that consists of manganese and carbonate ions.
Manganese Carbonate has a redox potential of 0.38 V, which is higher than that of anhydrous sodium (0.28 V) and can be used as an oxidation catalyst to treat wastewater.
Manganese carbonate can be synthesized by the reaction between magnesium salt and particle or zirconium oxide in the presence of oxygen gas.
Manganese Carbonate is usually white in color and has a particle size of about 3 μm.
Manganese carbonate has been used for the treatment of liver lesions caused by manganism, which is a disorder resulting from excessive exposure to manganese compounds.
Manganese carbonate also finds use in electrochemical impedance spectroscopy (EIS), as it has been shown to have good electrical conductivity properties with low dielectric constant values.

Manganese carbonate Chemical Properties
Melting point: 350°C (dec.)
Density: 3.12 g/mL at 25 °C(lit.)
Solubility: dilute aqueous acid: slightly soluble(lit.)
Form: Powder
Specific Gravity: 3.125
Color: Light brown to violet
Water Solubility: Soluble in water(0.065g/L), dilute inorganic acids. Insoluble alcohol.
Merck: 14,5726
Solubility Product Constant (Ksp): pKsp: 10.63
Exposure limits ACGIH: TWA 0.02 mg/m3; TWA 0.1 mg/m3
OSHA: Ceiling 5 mg/m3
NIOSH: IDLH 500 mg/m3; TWA 1 mg/m3; STEL 3 mg/m3
Stability: Stable. Incompatible with strong acids, strong oxidizing agents. May be moisture senstive.
LogP: -0.809 (est)
CAS DataBase Reference: 598-62-9(CAS DataBase Reference)
EPA Substance Registry System: Manganese carbonate (598-62-9)

Characters rose-colored triangular rhomboid crystals or amorphous bright white brown powder.
Relative density 3.125 solubility is almost insoluble in water, slightly soluble in water containing carbon dioxide.
Soluble in dilute inorganic acid, slightly soluble in common organic acids, insoluble in alcohol and liquid ammonia.

Structure and production
MnCO3 adopts a structure like calcite, consisting of manganese ions in an octahedral coordination geometry.
Treatment of aqueous solutions of manganese nitrate with ammonia and carbon dioxide leads to precipitation of this faintly pink solid.
The side product, ammonium nitrate is used as fertilizer.

Reactions
Manganese carbonate is insoluble in water but, like most carbonates, hydrolyses upon treatment with acids to give water-soluble salts.
Manganese carbonate decomposes with release of carbon dioxide, i.e. calcining, at 200 °C to give MnO1.88:
MnCO3 + 0.44 O2 → MnO1.8 + CO2
This method is sometimes employed in the production of manganese dioxide, which is used in dry-cell batteries and for ferrites.
Manganese carbonate is widely used as an additive to plant fertilizers to cure manganese deficient crops.
Manganese carbonate is also used in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.
Manganese carbonate is used in medicine as a hematinic.

Uses
The material of the telecommunication equipment component is used as a raw material for the production of ferrite.
Manganese carbonate is widely used as a catalyst for desulfurization, enamel pigment, Varnish drier, manganese salt and raw material for catalyst manufacturing.
Widely used as desulfurization catalyst, enamel pigment, manganese salt raw materials, also used in fertilizer, medicine, feed additives, electrode accessories.
Manganese carbonate (MnCO3) is used in the production of iron ore and as a chemical reagent.
Manganese carbonate occurs in nature as the mineral rhodochrosite (manganese spar).
This ore also is used to produce manganese dioxide (by electrolytic process).
Manganese carbonate is used as gemstones; and as a pigment (manganese white).

Manganese carbonate is extensively utilized as an additive to plant fertilizers to treat manganese deficient crops.
Manganese carbonate is also employed in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.
Manganese carbonate is utilized in medicine as a hematinic (a nutrient required for the formation of blood cells in the process of haematopoiesis.
The main hematinics are iron, B12, and folate).

Metallurgy: Manganese carbonate is an important source of manganese for the production of ferroalloys, which are alloys of iron and manganese.
Ferroalloys are used in the steel industry to improve the strength and hardness of steel.

Fertilizers: Manganese carbonate is an essential nutrient for plants, and manganese carbonate is used as a fertilizer to supply this nutrient to the soil.
Manganese carbonate helps in the synthesis of chlorophyll and plays a vital role in photosynthesis and overall plant growth.

Ceramics and Glass: Manganese carbonate is employed in the production of ceramics and glass.
Manganese carbonate acts as a colorant, imparting various shades of pink, purple, or brown to the final products.

Pigments and Paints: Manganese carbonate is employed as a pigment in various applications, including paints, coatings, and dyes.
Manganese carbonate can produce shades of pink, purple, and brown, depending on the concentration and the specific application.

Chemical Industry: Manganese carbonate serves as a precursor for the production of other manganese compounds.
Manganese carbonate is used in the synthesis of manganese oxide, manganese sulfate, and other manganese-based chemicals.

Health Supplements: Manganese carbonate can also be found in certain dietary supplements and multivitamins.
Manganese carbonate is an essential trace mineral required for normal growth, development, and overall health.

Preparation
Manganese carbonate is mined from its naturally occurring mineral rhodochrosite.
Manganese carbonate may be prepared in the laboratory as a palepink precipitate by adding sodium bicarbonate to a solution of manganese salt saturated with carbon dioxide.
Manganese carbonate obtained is monohydrate, MnCO3•H2O.
However, if the carbon dioxide-saturated solution, together with the above monohydrate precipitate, is heated in the absence of atmosphere oxygen, the monohydrate MnCO3•H2O is converted into the anhydrous MnCO3.

In the reactor, manganese sulfate is dissolved with water or steam, insoluble matters are removed by filtration, and purification is carried out with hydrogen sulfide to remove impurities such as heavy metals.
After heating and boiling, the mixture is filtered.
The obtained manganese sulfate solution and ammonium bicarbonate solution are subjected to metathesis reaction at 25~30 ℃ to generate manganese carbonate, which is then subjected to Suction filtration, washing and dehydration, drying may be performed at 80 to 90 °c.
Alternatively, the soft manganese ore powder is mixed with coal powder, and the manganese sulfate solution is obtained by reduction roasting and sulfuric acid leaching.
After filtration, the solution is neutralized with ammonium bicarbonate, and then vacuum filtered, dehydrated and dried.

Synonyms
MANGANESE CARBONATE
598-62-9
Manganese(II) carbonate
Manganous carbonate
Rhodochrosite
Manganese(2+) carbonate
Natural rhodochrosite
Manganese carbonate (1:1)
Manganese carbonate (MnCO3)
Carbonic acid, manganese salt
CCRIS 3660
HSDB 790
Manganese(2+) carbonate (1:1)
EINECS 209-942-9
NSC 83512
UNII-9ZV57512ZM
17375-37-0
9ZV57512ZM
manganese(2+);carbonate
MANGANUM CARBONICUM
EC 209-942-9
NSC-83512
manganese(ii)carbonate
Carbonic acid, manganese(2+) salt (1:1)
MFCD00011116
EINECS 241-414-3
RHODOCHROSITE [INCI]
SCHEMBL32918
DTXSID1042108
MANGANESE CARBONATE [MI]
XMWCXZJXESXBBY-UHFFFAOYSA-L
MANGANESE CARBONATE [HSDB]
MANGANUM CARBONICUM [HPUS]
CARBONIC ACID,MANGANESE SALT
Manganese(II) carbonate, Mn 44%
MANGANESE CARBONATE [WHO-DD]
Manganese Carbonate, Powder, Reagent
Manganese(II) carbonate, min. 90%
AKOS015903237
Manganese(II) carbonate, p.a., 44%
Q414659
J-521674
Manganese(II) carbonate, 99.985% (metals basis)
Manganese(II) carbonate, >=99.9% trace metals basis
Manganese(II) carbonate hydrate, 44-46% Mn basis (KT)
11-((5-Dimethylaminonaphthalene-1-sulfonyl) amino)undecanoic
MANGANESE CARBONATE
Manganese Carbonate is a pale pink, water-insoluble solid.
Manganese Carbonate is mostly pink to light brown and odorless.
Manganese Carbonate is a compound with the chemical formula MnCO3.


CAS Number: 598-62-9
EC Number: 209-942-9
MDL number: MFCD00011116
Chemical formula: MnCO3



SYNONYMS:
Carbonic acid (acd/name 4.0), Carbonic acid, manganese(2+) salt (1:1), Manganese carbonate (1:1), Manganese carbonate (MnCO3), Manganese carbonate, MnCO3, Manganese carbonic acid, Manganese(2+) carbonate, Manganese(2+) carbonate (1:1), Manganese(II) carbonate, Manganous carbonate, RHODOCHROSITE, Manganous carbonate, Manganese carbonate, ManganeseCarbonateAr, Manganese(Ⅱ)carbonate, MANGANESE(+2)CARBONATE, Manganese(II) carbonate, Manganese(II) carbonate, tech., MANGANESE CARBONATE, FOR ANALYTICAL PURPOSE, Manganese(II) carbonate, MANGANESE CARBONATE, 598-62-9, Manganese(II) carbonate, Manganous carbonate, Rhodochrosite, Manganese(2+) carbonate, Natural rhodochrosite, Carbonic acid, manganese salt, Manganese carbonate (1:1), Manganese carbonate (MnCO3), CCRIS 3660, HSDB 790, 17375-37-0, manganese(2+);carbonate, Manganese(2+) carbonate (1:1), EINECS 209-942-9, NSC 83512, UNII-9ZV57512ZM, 9ZV57512ZM, MANGANUM CARBONICUM, EC 209-942-9, NSC-83512, manganese(ii)carbonate, Carbonic acid, manganese(2+) salt (1:1), MFCD00011116, Manganesecarbonate, EINECS 241-414-3, SCHEMBL32918, DTXSID1042108, MANGANESE CARBONATE [MI], MANGANESE CARBONATE [HSDB], MANGANUM CARBONICUM [HPUS], CARBONIC ACID,MANGANESE SALT, Manganese(II) carbonate, Mn 44%, MANGANESE CARBONATE [WHO-DD], Manganese(II) carbonate, min. 90%, AKOS015903237, Manganese(II) carbonate, p.a., 44%, NS00080594, Q414659, J-521674, Manganese(II) carbonate, 99.985% (metals basis), Manganese(II) carbonate, >=99.9% trace metals basis, Manganese(II) carbonate hydrate, 44-46% Mn basis (KT), Manganese carbonate, Manganese(2+) carbonate, Manganous carbonate, Manganese (II) carbonate, manganese carbonate, rhodochromite, Manganese(2+) carbonate, Manganese (2+) carbonate (1:1), Manganese(II) carbonate, Manganese(2+) carbonate, carbonic acid, manganese(2+) salt (1:1) manganese carbonate, manganese ii carbonate, manganous carbonate, manganese 2+ carbonate, natural rhodochrosite, manganese carbonate 1:1, rhodochrosite, manganese carbonate mnco3, unii-9zv57512zm, ccris 3660, RHODOCHROSITE, MANGANESE(+2)CARBONATE, mangane carbonate, MANGANESE(II) CARBONATE, 99.9+%, MANGANESE(II) CARBONATE, 99.99%, MANGANESE(II) CARBONATE TECHNICAL, MANGANESE(II) CARBONATE EXTRA PURE, MANGANESE CARBONATE 44+% MN TECH GARDE RHODOCHROSITE, MANGANESE(II) CARBONATE, tansuanm, mangane carbonate, MANGANOUS CARBONATE, MANGANESE CARBONATE, anese(II) carbonate, naturalrhodochrosite, ManganeseCarbonateAr, Manganese(Ⅱ)carbonate, Carbonic acid, manganese(2+) salt (1:1), Manganese carbonate (1:1), Manganese carbonate (MnCO3), Manganese(2+) carbonate, Manganese(2+) carbonate (1:1), Manganous carbonate, Natural rhodochrosite,



Manganese Carbonate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Manganese Carbonate is a compound with the chemical formula MnCO3.


Manganese Carbonate occurs naturally as the mineral rhodochrosite but it is typically produced industrially.
Manganese Carbonate is a pale pink, water-insoluble solid.
Approximately 20,000 metric tonnes were produced in 2005.
Manganese Carbonate is a compound with the chemical formula MnCO3.


Manganese Carbonate occurs naturally as the mineral rhodochrosite, but it is usually produced industrially.
Manganese Carbonate is a pale pink, water-insoluble solid.
Manganese Carbonate is mostly pink to light brown and odorless.


In nature, Manganese Carbonate also occurs as the mineral rhodochrosite.
Manganese Carbonate is basically insoluble in water and generally readily convertible to other manganese compounds.
Manganese Carbonate is a water-insoluble manganese source which occurs naturally in the form of mineral rhodochrosite.


Manganese Carbonate can easily be converted to other manganese compounds, such as the oxide by heating.
Manganese Carbonate can be widely applied in various fields.
In the field of agriculture, Manganese Carbonate is commonly used as an additive to plant fertilizers, which is effective to cure the crops with manganese deficiency.


Manganese Carbonate can also be applied in ceramics as a porcelain glaze, glaze colorant and flux and it serves as a catalyst in viscose process.
Besides, Manganese Carbonate has been proved to be used as a hematinic in the field of medicine.
Other applications of Manganese Carbonate involve in health foods, chemical industry and etc.


Manganese Carbonate is a brown powder.
Manganese Carbonate is a chemical compound that has a structure similar to calcite, with octahedral co-ordination symmetry.
Manganese Carbonate is a carbonate that is insoluble in water and on treatment with acid it gives water soluble salts.


Manganese Carbonate is a widely used material in plant fertilization as an additive that cures the magnesium deficiency in crops.
Manganese Carbonate is a compound with the chemical formula MnCO3.
Manganese Carbonate occurs naturally as the mineral rhodochrosite.


Manganese Carbonate is a water insoluble Manganese source that can easily be converted to other Manganese compounds, such as the oxide by heating (calcination).
Carbonate compounds also give off carbon dioxide when treated with dilute acids.


Manganese Carbonate is generally immediately available in most volumes.
Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards.
Manganese Carbonate is a compound with the chemical formula MnCO3.


Manganese Carbonate occurs naturally as the mineral rhodochrosite.
Manganese Carbonate is a chemical compound with the formula MnCO3.
Manganese Carbonate is a pink-colored solid that occurs naturally as the mineral rhodochrosite.


Manganese Carbonate is primarily composed of manganese (Mn), carbon (C), and oxygen (O).
Manganese Carbonate, also known as manganese(II) carbonate, is a chemical compound.
Manganese Carbonate is a brownish powder with a chemical formula of MnCO3.


Manganese Carbonate can be heated to produce manganese(II) oxide and carbon dioxide.
Manganese Carbonate is made by reacting a soluble manganese compound such as manganese(II) chloride with sodium carbonate.
Manganese Carbonate is a rose colored crystal, sometimes white when precipitated.
Manganese Carbonate is soluble in inorganic acids, and almost insoluble in organic acids and water.



USES and APPLICATIONS of MANGANESE CARBONATE:
Manganese Carbonate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Manganese Carbonate is used in the following products: fertilisers.


Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Release to the environment of Manganese Carbonate can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).


Other release to the environment of Manganese Carbonate is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)).


Manganese Carbonate can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and vehicles.
Manganese Carbonate can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), plastic used for large surface area articles (e.g. construction and building materials for flooring, insulation) and rubber (e.g. tyres, shoes, toys).


Manganese Carbonate is used in the following products: fertilisers, metal surface treatment products, laboratory chemicals and pH regulators and water treatment products.
Manganese Carbonate has an industrial use resulting in manufacture of another substance (use of intermediates).


Manganese Carbonate is used in the following areas: agriculture, forestry and fishing, formulation of mixtures and/or re-packaging and scientific research and development.
Manganese Carbonate is used for the manufacture of: chemicals, , metals and fabricated metal products.


Other release to the environment of Manganese Carbonate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Manganese Carbonate is used in the following products: fertilisers, metals and pH regulators and water treatment products.


Release to the environment of Manganese Carbonate can occur from industrial use: formulation of mixtures and formulation in materials.
Manganese Carbonate is used in the following products: metal surface treatment products, pH regulators and water treatment products and fertilisers.
Manganese Carbonate has an industrial use resulting in manufacture of another substance (use of intermediates).


Release to the environment of Manganese Carbonate can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, in the production of articles, in processing aids at industrial sites, of substances in closed systems with minimal release and as processing aid.


Release to the environment of Manganese Carbonate can occur from industrial use: manufacturing of the substance.
Manganese Carbonate is used in fertilizers, metal surface treatment products, pH regulators, water treatment products, machine wash liquids/detergents, automotive care products, paints and coatings or adhesives, fragrances and air fresheners.


Manganese Carbonate has an industrial use that results in the production of another substance (use of intermediates).
Manganese Carbonate is used in agriculture, forestry and fisheries, and blend formulations and/or repackaging.
Manganese Carbonate is used in the manufacture of chemicals, metals and fabricated metal products.


Manganese Carbonate is the compound containing manganese (II) ion and carbonic acid components. Widely used in articles, formulation or repackaging, industrial sites and manufacturing.
Manganese Carbonate is used in the following areas: agriculture, forestry and fishing.


Manganese Carbonate is used for the manufacture of: chemicals, fabricated metal products and metals.
In the construction industry, Manganese Carbonate is used in cementitious mixtures to accelerate the curing process and to give cementitious mixtures a higher hardness.


Manganese Carbonate, also known as manganous carbonate, is found in numerous metals and is used in the preparation of other manganese salts.
In Manganese Carbonate's pure form is used in medicine for treating anaemia.
Manganese Carbonate is also applied for metal surface treatment and in the welding industry.


In agriculture Manganese Carbonate is used for manganese deficiency or prophylaxis.
Manganese Carbonate is ideal as a long-term source of manganese because it is insoluble in water and therefore does not leach out of the soil, and the acids and bacteria in the compound make the manganese available to the plants.


Manganese (Mn) deficiency is a plant disorder that is often confused with, and occurs in conjunction with, iron deficiency.
It is most common in swampy soils and where organic matter content is high.
Manganese may be unavailable to plants with high pH.


Onions, apples, peas, French beans, cherries and raspberries may be affected by deficiency, with symptoms including yellowing leaves with small areas of green.
The plant may appear healthy as new leaf growth may appear normal.


Brown spots on the leaf surfaces may occur and severely affected leaves will turn brown and die back.
Manganese Carbonate is used in the production of iron ore and as a chemical reagent.
Manganese Carbonate occurs in nature as the mineral rhodochrosite [14476-12-1] (manganese spar).


Manganese Carbonate ore also is used to produce manganese dioxide (by electrolytic process).
Manganese Carbonate is used as gemstones; and as a pigment (manganese white).
Manganese Carbonate is used as pigment"manganese white"; drier for varnishes; in feeds.


Manganese Carbonate is extensively utilized as an additive to plant fertilizers to treat manganese deficient crops.
Manganese Carbonate is also employed in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.
Manganese Carbonate is utilized in medicine as a hematinic (a nutrient required for the formation of blood cells in the process of hematopoiesis.


The main hematinics are iron, B12, and folate).
Manganese Carbonate is used for Pigment, Varnish Drier.
Pigment, varnish drier Manganese Carbonate is used as an additive to plant fertilizers, glaze colorant in ceramics, pigment and drier for varnishes.


Manganese Carbonate is also used as an ingredient in welding rod, animal feed additive as well as to prepare other manganese salts and pharmaceuticals.
Manganese Carbonate is also used in medicine as a hematinic and in health foods, in flux and in concrete stains.
Manganese Carbonate is used as an additive to plant fertilizers to cure manganese deficient crops.


Manganese Carbonate is used in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.
Manganese Carbonate has many grades: Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP Grade (European Pharmacopoeia/British Pharmacopoeia).


Other Uses other than pharmaceutical usage: Manganese Carbonate is used for metal surface treatment, for preparation of other manganese salts and in the welding industry.
Manganese Carbonate is used as an additive to plant fertilizers, glaze colorant in ceramics, pigment and drier for varnishes.


Manganese Carbonate is also used as an ingredient in welding rod, animal feed additive as well as to prepare other manganese salts and pharmaceuticals.
Manganese Carbonate is also used in medicine as a hematinic and in health foods, in flux and in concrete stains.
Manganese Carbonate is mainly used for producing magnetic materials.


Manganese Carbonate is used synthetic manganese dioxide.
Manganese Carbonate is used manufacturing organic manganous salts.
Manganese Carbonate is used paint dryer


Manganese Carbonate is used stocks or desulfurate cataluzer. Manganese Carbonate is used porcelain/ceramic glaze and electrode
Manganese Carbonate is extensively applied as an additive to plant fertilizers to cure manganese deficient crops.
Manganese Carbonate is also used in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.


Pharmaceutically, Manganese Carbonate is utilized in medicines as a hematinic.
Manganese Carbonate is widely used as desulfurization catalyst, enamel pigment, manganese salt raw materials, also used in fertilizer, medicine, feed additives, electrode accessories


Manganese Carbonate is widely used as an additive to plant fertilizers, in clay and ceramics, concrete, and occasionally in dry-cell batteries.
Manganese Carbonate is used as a pigment (manganese white), drier for varnishes, animal feed additive, welding rod ingredient, and to make other manganese salts and pharmaceuticals.


-In ceramics, Manganese Carbonate is used to create metallic, black, brown or purple/plum glazes.
Manganese Carbonate decomposes on heating to MnO2 and CO2; must be heated above 1080 C to decompose MnO2 to MnO.
Source of manganese in glazes.

Carbonate is weaker but better dispersed than oxide or dioxide.
The result is a brown color.
Purple colors are obtained with alkaline flux or lead.

Flux with aluminum oxide is used to give a pink color (which is fire resistant).
A metallic tint can be produced by mixing in larger quantities with copper, e.g. Reynolds Gold Metallic glaze.


-In cosmetics, Manganese Carbonate is used in the form of white dyes, in this case listed as CI 77713.
As an active substance, Manganese Carbonate is used as a binder or absorbent.
Manganese Carbonate also allows the PH of products to be regulated.

Manganese Carbonate has a restriction of use in Europe: IV/139.
Main functions of Manganese Carbonate: Absorbent: Absorbs water (or oil) in dissolved or fine form.

Binding agent: Manganese Carbonate allows the combination of various cosmetic ingredients.
Volumetric: Manganese Carbonate veduces the apparent density of cosmetics.
Cosmetic coloring: coloring of cosmetics and/or coloring of the skin.

Transparency regulator: Manganese Carbonate reduces the transparency or opacity of cosmetics.
Most common concentrations of Manganese Carbonate in cosmetics is 0,65%.


-Metallurgy uses of Manganese Carbonate:
Manganese Carbonate is an important source of manganese for the production of ferroalloys, which are alloys of iron and manganese.
Ferroalloys are used in the steel industry to improve the strength and hardness of steel.


-Fertilizers uses of Manganese Carbonate:
Manganese is an essential nutrient for plants, and Manganese Carbonate is used as a fertilizer to supply this nutrient to the soil.
Manganese Carbonate helps in the synthesis of chlorophyll and plays a vital role in photosynthesis and overall plant growth.


-Ceramics and Glass uses of Manganese Carbonate:
Manganese Carbonate is employed in the production of ceramics and glass.
Manganese Carbonate acts as a colorant, imparting various shades of pink, purple, or brown to the final products.


-Pigments and Paints uses of Manganese Carbonate:
Manganese Carbonate is employed as a pigment in various applications, including paints, coatings, and dyes.
Manganese Carbonate can produce shades of pink, purple, and brown, depending on the concentration and the specific application.


-Chemical Industry uses of Manganese Carbonate:
Manganese Carbonate serves as a precursor for the production of other manganese compounds.
Manganese Carbonate is used in the synthesis of manganese oxide, manganese sulfate, and other manganese-based chemicals.


-Health Supplements uses of Manganese Carbonate:
Manganese Carbonate can also be found in certain dietary supplements and multivitamins.
Manganese is an essential trace mineral required for normal growth, development, and overall health.



COMPOUND TYPE OF MANGANESE CARBONATE:
*Food Toxin
*Inorganic Compound
*Manganese Compound
*Natural Compound
*Organic Compound
*Pollutant



PREPARATION OF MANGANESE CARBONATE:
Manganese Carbonate is mined from its naturally occurring mineral rhodochrosite.
Manganese Carbonate may be prepared in the laboratory as a palepink precipitate by adding sodium bicarbonate to a solution of manganese(II) salt saturated with carbon dioxide.

Manganese Carbonate obtained is monohydrate, MnCO3•H2O.
However, if the carbon dioxide-saturated solution, together with the above monohydrate precipitate, is heated in the absence of atmosphere oxygen, the monohydrate MnCO3•H2O is converted into the anhydrous MnCO3.



ALTERNATIVE PARENTS OF MANGANESE CARBONATE:
*Organic transition metal salts
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF MANGANESE CARBONATE:
*Carbonic acid
*Organic transition metal salt
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organic salt
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



SOLUBILITY OF MANGANESE CARBONATE:
Manganese Carbonate is almost insoluble in water, slightly soluble in water containing carbon dioxide.
Manganese Carbonate is soluble in dilute inorganic acid, slightly soluble in ordinary organic acid, insoluble in alcohol and liquid ammonia.



PHYSICAL AND CHEMICAL PROPERTIES OF MANGANESE CARBONATE:
*Characters rose-colored triangular rhomboid crystals or amorphous bright white brown powder.
*relative density 3.125
*solubility is almost insoluble in water, slightly soluble in water *containing carbon dioxide.
*Soluble in dilute inorganic acid, slightly soluble in common organic acids, insoluble in alcohol and liquid ammonia.



PRODUCTION AND USES OF MANGANESE CARBONATE:
Treatment of aqueous solutions of manganese(II) salts with alkali metal carbonates leads to precipitation of this faintly pink solid.
The carbonate is insoluble in water but, like most carbonates, hydrolyses upon treatment with acids to give water-soluble salts.
Manganese Carbonate decomposes with release of carbon dioxide at 200 °C to give manganese(II) oxide:

MnCO3 → MnO + CO2
This method is sometimes employed in the production of manganese dioxide for dry-cell batteries and for ferrites.

Manganese Carbonate is widely used as an additive to plant fertilizers to cure manganese deficient crops.
Manganese Carbonate is also used in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.



PHYSICAL AND CHEMICAL PROPERTIES OF MANGANESE CARBONATE:
» Pink to almost white powder when freshly precipitated; It is in the form of a rhombus, calcite structure.
Manganese Carbonate is a water insoluble Manganese source that can easily be converted to other Manganese compounds, such as the oxide by heating (calcination).

Carbonate compounds also give off carbon dioxide when treated with dilute acids.
Manganese Carbonate is generally immediately available in most volumes.
Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards.

Nanoscale elemental powders and suspensions, as alternative high surface area forms, may be considered.
American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.

Typical and custom packaging is available.
Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.



PRODUCTION AND USES OF MANGANESE CARBONATE:
Treatment of aqueous solutions of manganese(II) salts with alkali metal carbonates leads to precipitation of this faintly pink solid.
Manganese Carbonate is insoluble in water but, like most carbonates, hydrolyses upon treatment with acids to give water-soluble salts.
Manganese Carbonate will decompose, releasing CO2 at 200 °C to give manganese(II) oxide:

Here is the reaction formula:
MnCO3 → MnO + CO2
This method is sometimes used in the production of manganese dioxide for dry-cell batteries and for ferrites.



REACTIONS AND USES OF MANGANESE CARBONATE:
The carbonate is insoluble in water but, like most carbonates, hydrolyses upon treatment with acids to give water-soluble salts.
Manganese Carbonate decomposes with release of carbon dioxide, i.e. calcining, at 200 °C to give MnO1.88:

MnCO3 + 0.44 O2 → MnO1.8 + CO2
This method is sometimes employed in the production of manganese dioxide, which is used in dry-cell batteries and for ferrites.

Manganese Carbonate is widely used as an additive to plant fertilizers to cure manganese deficient crops.
Manganese Carbonate is also used in health foods, in ceramics as a glaze colorant and flux, and in concrete stains.

Manganese Carbonate is used in medicine as a hematinic.
Rhodochrosite is a mineral with formula of Mn2+CO3 or Mn(CO3).
The corresponding IMA (International Mineralogical Association) number is IMA1962 s.p..
The IMA symbol is Rds.



STRUCTURE AND PRODUCTION OF MANGANESE CARBONATE:
Manganese Carbonate adopts a structure like calcite, consisting of manganese(II) ions in an octahedral coordination geometry.
Treatment of aqueous solutions of manganese(II) nitrate with ammonia and carbon dioxide leads to precipitation of this faintly pink solid.
The side product, ammonium nitrate is used as fertilizer.



PHYSICAL and CHEMICAL PROPERTIES of MANGANESE CARBONATE:
Chemical Formula: CH2MnO3
Average Molecular Mass: 116.963 g/mol
Monoisotopic Mass: 116.938 g/mol
CAS Registry Number: 598-62-9
IUPAC Name: carbonic acid manganese
Traditional Name: carbonic acid manganese
SMILES: [Mn].OC(O)=O
InChI Identifier: InChI=1S/CH2O3.Mn/c2-1(3)4;/h(H2,2,3,4);
InChI Key: SDPBZSAJSUJVAT-UHFFFAOYSA-N
Melting Point: 350°C (decomposition)
Color: Brown to Violet
Physical Form: Powder
Assay Percent Range: 99.99% (metals basis)
Solubility Information: Soluble in water (0.065 g/L),
dilute inorganic acids.

Insoluble in alcohol.
Formula Weight: 114.95
Odor: Odorless
Appearance: Light brown to violet powder
Density: 3.125
Chemical Name or Material: Manganese(II) carbonate
CAS: 598-62-9
EINECS: 209-942-9
InChI: InChI=1/CH2O3.Mn/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
Molecular Formula: CMnO3
Molar Mass: 114.95
Density: 3.12 g/mL at 25°C (lit.)
Melting Point: 350°C (dec.)
Water Solubility: Soluble in water (0.065 g/L),
dilute inorganic acids.
Insoluble in alcohol.

Appearance: Pink to white-like powder
Specific Gravity: 3.125
Color: Light brown to violet
Solubility Product Constant (Ksp): pKsp: 10.63
Merck: 14,5726
Storage Condition: Room Temperature
Stability: Stable.
Incompatible with strong acids, strong oxidizing agents.
May be moisture sensitive.
Sensitive: Easily absorbing moisture
MDL: MFCD00011116
Density: 3.12 g/mL at 25 °C (lit.)
Boiling Point: 333.6°C at 760 mmHg

Melting Point: 350°C (dec.)
Molecular Formula: CMnO3
Molecular Weight: 114.947
Flash Point: 169.8°C
Exact Mass: 114.922791
PSA: 63.19000
Stability: Stable.
Incompatible with strong acids, strong oxidizing agents.
May be moisture sensitive
Chemical formula: MnCO3
Molar mass: 114.95 g/mol
Appearance: White to faint pink solid
Density: 3.12 g/cm³
Melting point: 200–300 °C (392–572 °F; 473–573 K), decomposes

Solubility in water: negligible
Solubility product (Ksp): 2.24 x 10⁻¹¹
Solubility: soluble in dilute acid, CO₂; insoluble in alcohol, ammonia
Magnetic susceptibility (χ): +11,400·10⁻⁶ cm³/mol
Refractive index (nD): 1.597 (20 °C, 589 nm)
Crystal structure: hexagonal-rhombohedral
Heat capacity (C): 94.8 J/mol·K
Std molar entropy (S⦵298): 109.5 J/mol·K
Std enthalpy of formation (ΔfH⦵298): -881.7 kJ/mol
Gibbs free energy (ΔfG⦵): -811.4 kJ/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 0

Exact Mass: 114.922787 g/mol
Monoisotopic Mass: 114.922787 g/mol
Topological Polar Surface Area: 63.2Ų
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 18.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
Appearance Form: powder

Color: light brown
Odor: No data available
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: > 450 °C
Initial boiling point and boiling range: No data available
Flash point: Not applicable
Evaporation rate: No data available
Flammability (solid, gas): The product is not flammable.
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available

Relative density: 3.27 at 22 °C
Water solubility: 0.00363 g/L at 20 °C - slightly soluble
Partition coefficient: n-octanol/water:
Not applicable for inorganic substances
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity:
Viscosity, kinematic: No data available;
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available

Molecular Formula: MnCO3
EC / List no.: 209-942-9
CAS no.: 598-62-9
Molecular weight: 114.947 g/mol
Compound Formula: CMnO3
Molecular Weight: 114.95
Appearance: Light brown powder
Melting Point: >200 °C
Boiling Point: N/A
Density: 3.12 g/cm³
Solubility in H2O: N/A
Exact Mass: 114.922793
Monoisotopic Mass: 114.922791 Da
Linear Formula: MnCO3
MDL Number: MFCD00011116

EC No.: 209-942-9
Beilstein/Reaxys No.: N/A
Pubchem CID: 11726
IUPAC Name: manganese(2+) carbonate
SMILES: [Mn+2].[O-]C([O-])=O
InchI Identifier: InChI=1S/CH2O3.Mn/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
InchI Key: XMWCXZJXESXBBY-UHFFFAOYSA-L
CBNumber: CB5135235
Molecular Formula: CMnO3
Molecular Weight: 114.95
MDL Number: MFCD00011116
MOL File: 598-62-9.mol
Melting point: 350°C (dec.)
Density: 3.12 g/mL at 25 °C (lit.)

Solubility: dilute aqueous acid: slightly soluble (lit.)
Form: Powder
Specific Gravity: 3.125
Color: Light brown to violet
Water Solubility: Soluble in water (0.065 g/L), dilute inorganic acids.
Insoluble in alcohol.
Merck: 14,5726
Solubility Product Constant (Ksp): pKsp: 10.63
Exposure limits: ACGIH: TWA 0.02 mg/m³; TWA 0.1 mg/m³ OSHA:
Ceiling 5 mg/m³ NIOSH: IDLH 500 mg/m³; TWA 1 mg/m³; STEL 3 mg/m³
Stability: Stable.
Incompatible with strong acids, strong oxidizing agents.
May be moisture sensitive.

LogP: -0.809 (est)
FDA 21 CFR: 582.80
CAS DataBase Reference: 598-62-9 (CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 9ZV57512ZM
EPA Substance Registry System: Manganese carbonate (1:1) (598-62-9)
CAS: 598-62-9
Molecular Formula: CMnO3
Molecular Weight (g/mol): 114.946
MDL Number: MFCD00011116
InChI Key: XMWCXZJXESXBBY-UHFFFAOYSA-L
PubChem CID: 11726
IUPAC Name: manganese(2+); carbonate
SMILES: C(=O)([O-])[O-].[Mn+2]



FIRST AID MEASURES of MANGANESE CARBONATE:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of MANGANESE CARBONATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of MANGANESE CARBONATE:
-Extinguishing media:
*Suitable extinguishing media:
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MANGANESE CARBONATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MANGANESE CARBONATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
Hygroscopic.



STABILITY and REACTIVITY of MANGANESE CARBONATE:
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
no information available

MANGANESE DIOXIDE
MANGANESE DIOXIDE Manganese dioxide Manganese dioxide Manganese(IV) oxideMn4O2 Rutile-unit-cell-3D-balls.png Names IUPAC names Manganese oxide Manganese(IV) oxide Other names Pyrolusite, hyperoxide of manganese, black oxide of manganese, manganic oxide Identifiers CAS Number 1313-13-9 check 3D model (JSmol) Interactive image ChEBI CHEBI:136511 ☒ ChemSpider 14117 check ECHA InfoCard 100.013.821 Edit this at Wikidata EC Number 215-202-6 PubChem CID 14801 RTECS number OP0350000 UNII TF219GU161 check CompTox Dashboard (EPA) DTXSID6042109 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula MnO 2 Molar mass 86.9368 g/mol Appearance Brown-black solid Density 5.026 g/cm3 Melting point 535 °C (995 °F; 808 K) (decomposes) Solubility in water insoluble Magnetic susceptibility (χ) +2280.0·10−6 cm3/mol[1] Structure[2] Crystal structure Tetragonal, tP6, No. 136 Space group P42/mnm Lattice constant a = 0.44008 nm, b = 0.44008 nm, c = 0.28745 nm Formula units (Z) 2 Thermochemistry[3] Heat capacity (C) 54.1 J·mol−1·K−1 Std molar entropy (So298) 53.1 J·mol−1·K−1 Std enthalpy of formation (ΔfH⦵298) −520.0 kJ·mol−1 Gibbs free energy (ΔfG˚) −465.1 kJ·mol−1 Hazards Safety data sheet ICSC 0175 EU classification (DSD) (outdated) Harmful (Xn) Oxidizer (O) R-phrases (outdated) R20/22 S-phrases (outdated) (S2), S25 NFPA 704 (fire diamond) NFPA 704 four-colored diamond 112OX Flash point 535 °C (995 °F; 808 K) Related compounds Other anions Manganese disulfide Other cations Technetium dioxide Rhenium dioxide Related manganese oxides Manganese(II) oxide Manganese(II,III) oxide Manganese(III) oxide Manganese heptoxide Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references Manganese(IV) oxide is the inorganic compound with the formula MnO 2. This blackish or brown solid occurs naturally as the mineral pyrolusite, which is the main ore of manganese and a component of manganese nodules. The principal use for MnO2 is for dry-cell batteries, such as the alkaline battery and the zinc-carbon battery.[4] MnO2 is also used as a pigment and as a precursor to other manganese compounds, such as KMnO4. It is used as a reagent in organic synthesis, for example, for the oxidation of allylic alcohols. MnO2 in the α polymorph can incorporate a variety of atoms (as well as water molecules) in the "tunnels" or "channels" between the manganese oxide octahedra. There is considerable interest in α-MnO2 as a possible cathode for lithium ion batteries.[5][6] Structure Several polymorphs of MnO 2 are claimed, as well as a hydrated form. Like many other dioxides, MnO 2 crystallizes in the rutile crystal structure (this polymorph is called pyrolusite or β-MnO 2), with three-coordinate oxide and octahedral metal centres.[4] MnO 2 is characteristically nonstoichiometric, being deficient in oxygen. The complicated solid-state chemistry of this material is relevant to the lore of "freshly prepared" MnO 2 in organic synthesis.[citation needed] The α-polymorph of MnO 2 has a very open structure with "channels" which can accommodate metal atoms such as silver or barium. α-MnO 2 is often called hollandite, after a closely related mineral. Production Naturally occurring manganese dioxide contains impurities and a considerable amount of manganese(III) oxide. Only a limited number of deposits contain the γ modification in purity sufficient for the battery industry. Production of batteries and ferrite (two of the primary uses of manganese dioxide) requires high purity manganese dioxide. Batteries require "electrolytic manganese dioxide" while ferrites require "chemical manganese dioxide".[7] Chemical manganese dioxide One method starts with natural manganese dioxide and converts it using dinitrogen tetroxide and water to a manganese(II) nitrate solution. Evaporation of the water leaves the crystalline nitrate salt. At temperatures of 400 °C, the salt decomposes, releasing N 2O 4 and leaving a residue of purified manganese dioxide.[7] These two steps can be summarized as: MnO 2 + N 2O 4 ⇌ Mn(NO 3) 2 In another process manganese dioxide is carbothermically reduced to manganese(II) oxide which is dissolved in sulfuric acid. The filtered solution is treated with ammonium carbonate to precipitate MnCO 3. The carbonate is calcined in air to give a mixture of manganese(II) and manganese(IV) oxides. To complete the process, a suspension of this material in sulfuric acid is treated with sodium chlorate. Chloric acid, which forms in situ, converts any Mn(III) and Mn(II) oxides to the dioxide, releasing chlorine as a by-product.[7] A third process involves manganese heptoxide and manganese monoxide. The two reagents combine with a 1:3 ratio to form manganese dioxide: Mn 2O 7 + 3 MnO → 5 MnO 2 Lastly, the action of potassium permanganate over manganese sulfate crystals produces the desired oxide.[8] 2 KMnO 4 + 3 MnSO 4 + 2 H 2O→ 5 MnO 2 + K 2SO 4 + 2 H 2SO 4 Electrolytic manganese dioxide Electrolytic manganese dioxide (EMD) is used in zinc–carbon batteries together with zinc chloride and ammonium chloride. EMD is commonly used in zinc manganese dioxide rechargeable alkaline (Zn RAM) cells also. For these applications, purity is extremely important. EMD is produced in a similar fashion as electrolytic tough pitch (ETP) copper: The manganese dioxide is dissolved in sulfuric acid (sometimes mixed with manganese sulfate) and subjected to a current between two electrodes. The MnO2 dissolves, enters solution as the sulfate, and is deposited on the anode. Reactions The important reactions of MnO 2 are associated with its redox, both oxidation and reduction. Reduction MnO 2 is the principal precursor to ferromanganese and related alloys, which are widely used in the steel industry. The conversions involve carbothermal reduction using coke:[citation needed] MnO 2 + 2 C → Mn + 2 CO The key reactions of MnO 2 in batteries is the one-electron reduction: MnO 2 + e− + H+ → MnO(OH) MnO 2 catalyses several reactions that form O 2. In a classical laboratory demonstration, heating a mixture of potassium chlorate and manganese dioxide produces oxygen gas. Manganese dioxide also catalyses the decomposition of hydrogen peroxide to oxygen and water: 2 H 2O 2 → 2 H 2O + O 2 Manganese dioxide decomposes above about 530 °C to manganese(III) oxide and oxygen. At temperatures close to 1000 °C, the mixed-valence compound Mn 3O 4 forms. Higher temperatures give MnO. Hot concentrated sulfuric acid reduces the MnO 2 to manganese(II) sulfate:[4] 2 MnO 2 + 2 H 2SO 4 → 2 MnSO 4 + O 2 + 2 H 2O The reaction of hydrogen chloride with MnO 2 was used by Carl Wilhelm Scheele in the original isolation of chlorine gas in 1774: MnO 2 + 4 HCl → MnCl 2 + Cl 2 + 2 H 2O As a source of hydrogen chloride, Scheele treated sodium chloride with concentrated sulfuric acid.[4] Eo (MnO 2(s) + 4 H+ + 2 e− ⇌ Mn2+ + 2 H 2O) = +1.23 V Eo (Cl 2(g) + 2 e− ⇌ 2 Cl−) = +1.36 V The standard electrode potentials for the half reactions indicate that the reaction is endothermic at pH = 0 (1 M [H+ ]), but it is favoured by the lower pH as well as the evolution (and removal) of gaseous chlorine. This reaction is also a convenient way to remove the manganese dioxide precipitate from the ground glass joints after running a reaction (i. e., an oxidation with potassium permanganate). Oxidation Heating a mixture of KOH and MnO 2 in air gives green potassium manganate: 2 MnO 2 + 4 KOH + O 2 → 2 K 2MnO 4 + 2 H 2O Potassium manganate is the precursor to potassium permanganate, a common oxidant. Applications The predominant application of MnO 2 is as a component of dry cell batteries: alkaline batteries and so called Leclanché cell, or zinc–carbon batteries. Approximately 500,000 tonnes are consumed for this application annually.[9] Other industrial applications include the use of MnO 2 as an inorganic pigment in ceramics and in glassmaking. Organic synthesis A specialized use of manganese dioxide is as oxidant in organic synthesis.[10] The effectiveness of the reagent depends on the method of preparation, a problem that is typical for other heterogeneous reagents where surface area, among other variables, is a significant factor.[11] The mineral pyrolusite makes a poor reagent. Usually, however, the reagent is generated in situ by treatment of an aqueous solution KMnO 4 with a Mn(II) salt, typically the sulfate. MnO 2 oxidizes allylic alcohols to the corresponding aldehydes or ketones:[12] cis-RCH=CHCH 2OH + MnO 2 → cis-RCH=CHCHO + MnO + H 2O The configuration of the double bond is conserved in the reaction. The corresponding acetylenic alcohols are also suitable substrates, although the resulting propargylic aldehydes can be quite reactive. Benzylic and even unactivated alcohols are also good substrates. 1,2-Diols are cleaved by MnO 2 to dialdehydes or diketones. Otherwise, the applications of MnO 2 are numerous, being applicable to many kinds of reactions including amine oxidation, aromatization, oxidative coupling, and thiol oxidation. See also List of inorganic pigments Manganese dioxide is a manganese molecular entity with formula MnO2. It is a manganese molecular entity and a metal oxide. Molecular Weight of Manganese dioxide: 86.937 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Hydrogen Bond Donor Count of Manganese dioxide: 0 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Hydrogen Bond Acceptor Count of Manganese dioxide: 2 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Rotatable Bond Count of Manganese dioxide: 0 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Exact Mass of Manganese dioxide: 86.927872 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Monoisotopic Mass of Manganese dioxide: 86.927872 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18) Topological Polar Surface Area of Manganese dioxide: 34.1 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Heavy Atom Count of Manganese dioxide: 3 Computed by PubChem Formal Charge of Manganese dioxide: 0 Computed by PubChem Complexity of Manganese dioxide: 18.3 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18) Isotope Atom Count of Manganese dioxide: 0 Computed by PubChem Defined Atom Stereocenter Count of Manganese dioxide: 0 Computed by PubChem Undefined Atom Stereocenter Count of Manganese dioxide: 0 Computed by PubChem Defined Bond Stereocenter Count of Manganese dioxide: 0 Computed by PubChem Undefined Bond Stereocenter Count of Manganese dioxide: 0 Computed by PubChem Covalently-Bonded Unit Count of Manganese dioxide: 1 Computed by PubChem Compound of Manganese dioxide is Canonicalized : Yes sites in France have yielded large numbers of small black blocs. The usual interpretation is that these ‘manganese oxides’ were collected for their colouring properties and used in body decoration, potentially for symbolic expression. Neanderthals habitually used fire and if they needed black material for decoration, soot and charcoal were readily available, whereas obtaining manganese oxides would have incurred considerably higher costs. Compositional analyses lead us to infer that late Neanderthals at Pech-de-l’Azé I were deliberately selecting manganese dioxide. Combustion experiments and thermo-gravimetric measurements demonstrate that manganese dioxide reduces wood’s auto-ignition temperature and substantially increases the rate of char combustion, leading us to conclude that the most beneficial use for manganese dioxide was in fire-making. With archaeological evidence for fire places and the conversion of the manganese dioxide to powder, we argue that Neanderthals at Pech-de-l’Azé I used manganese dioxide in fire-making and produced fire on demand. Combustion Experiments Starting from the chemical properties of manganese dioxide, a series of statistically-designed combustion experiments were used to assess whether fire making could be facilitated using wood and either commercial manganese dioxides (coded MD4 to MD6) or powdered material from the Pech-de-l’Azé I blocs (coded MD1 to MD3). Mixtures of wood ‘turnings’ and either manganese dioxide or powdered material from Pech-de-l’Azé I blocs were either heated or contacted with spark-lit tinder; the effects were monitored on video; thermal imaging camera temperature monitoring and XRD of the residues were used in selected cases (Methods). When heated on their own, the wood turnings released volatiles and produced a small amount of char but neither the volatiles nor the char ignited and no fire resulted (Supplementary Information 3). Similarly, spark-lit tinder did not ignite the wood. By contrast, mixtures of manganese dioxide with wood ignited, both when heated and when in contact with spark-lit tinder. Ignition produced glowing combustion and, in some cases, small red flames; the volatiles did not ignite and no yellow flames were produced (Fig. 2 and Supplementary Information 3). As little as 6% by weight of manganese dioxide MD6 was sufficient to facilitate combustion. Infrared thermal imaging data showed that whilst the wood turnings did not ignite at 350 oC, the mixtures of wood turnings with manganese dioxide could ignite at temperatures from around 250 oC and sustain combustion over a surprisingly wide range of temperatures (Supplementary Information 4). In identical experiments, powdered material from the Pech-de-l’Azé I blocs (MD1, MD2 and MD3) all facilitated the ignition of wood, although one bloc (MD1) was somewhat less effective. he composition of the black blocs at Pech-de-l’Azé I potentially provides evidence for their probable use. The blocs are predominantly manganese dioxide, not romanèchite and the combustion experiments and TGA have shown that only compositions predominantly containing manganese dioxide would be useful in fire-making. Both manganese dioxide and romanèchite would be useful in decoration32, although whether either would be preferred for decoration over the less ‘costly’ soot or charcoal is debatable. Whether Neanderthals at Pech-de-l’Azé were simply collecting black blocs from one source location or were selecting manganese dioxide in preference to other black materials and from multiple sources is important to our hypothesis that they were deliberately selecting and using manganese dioxide in fire making. Although the quantities and availabilities of different manganese oxides in the Middle Palaeolithic Dordogne region are unknown, there is evidence from both modern sources and from materials collected in the Palaeolithic, for a range of ‘manganese oxide’ materials that were available within reach of Pech-de-l’Azé. Manganese ore outcrops are numerous on the edges of the Massif Central38 and whilst most of the regional manganese ores had been extracted by the early twentieth century32, an original manganese ore source exists in the limestone within a few kilometres of Pech-de-l’Azé. The source contains traces of both manganese dioxide and romanèchite32. Discovery of pyrolusite and romanèchite in a Châtelperronian context at Roc-de-Combe7, thirteen kilometres from Pech-de-l’Azé, also indicates that both materials were available to late Middle Palaeolithic Neanderthals. Pyrolusite, romanèchite, todorokite, hollandite and other black manganese oxide ores were all used in the production of Upper Palaeolithic cave wall images in the vicinity, for example at Lascaux, approximately thirty kilometres from Pech-de-l’Azé19,32,33,34, implying their availability to Palaeolithic foragers. Without appropriate data on the variation of ‘manganese oxide’ compositions within and between geological sources in the region, the full implications of the Pech-de-l’Azé I bloc compositions for provenance are unknown. Whilst it might be argued that paragenesis might have produced a very variable single source, the relative uniformity of the manganese dioxide content of the blocs contrasts with the between-sample variation in arsenic, barium, cobalt and manganite contents and suggests that the blocs were not collected from one location. Equally, the availability of a range of ‘manganese oxides’ in the region suggests that the blocs were preferentially selected, implying both a capability to recognize the characteristics of these materials - although how this was accomplished is not clear - and an end-use that required the specific properties of manganese dioxide. Pech-de-l’Azé I is not unique and active selection rather than simple collection is supported by the presence of manganese dioxide apparently associated with fire places in the Châtelperronian layers at the Grotte-du-Renne, Arcy-sur-Cure15. The black materials said to be of manganese ores at other Mousterian sites (Supplementary Information 1, Table S1) may provide further evidence when the compositions are published. Our combustion experiments have shown that manganese dioxide promotes the ignition and combustion of wood and that this is not the case with romanèchite. The Pech-de-l’Azé I blocs would have had to have been ground to powder for use in facilitating fire lighting and there is archaeological evidence for grinding in the form of a grindstone and abraded blocs at Pech-de-l’Azé I27 and at Grotte-du-Renne, Arcy-sur-Cure15. Spark-lit tinder with manganese dioxide powder is one simple yet effective means of starting wood fires with substantially lower wood auto-ignition temperatures and high rate of combustion. Other methods may be envisaged. The clear benefits for fire-promotion and the presence of manganese dioxide at Neanderthal sites are not evidence that Neanderthals sourced and used manganese dioxide for fire making purposes nor that they did not use the black material for decorative purposes. However, if different ores have similar decorative properties and Neanderthals selected black manganese oxides that have pronounced oxidizing properties compared to others, we might infer that the choices reflect a fire-related end-use and vice-versa. Chalmin32 has shown that specifically for wall ‘painting’, romanèchite produces a more consistent streak than pyrolusite and both are considerably better than manganite; if powdered and dispersed in water, these particular materials are equally effective in decoration. There is apparently no decorative reason for Neanderthals to have favoured manganese oxides over soot and charcoal, or manganese dioxide over other manganese oxides. In contrast to the “low cost” fire residues, manganese dioxides would have had to have been sourced and transported, at considerably higher costs, which calls for an explanation of such investments outside of body decoration. Our preferred hypothesis is that Neanderthals sourced, selected and transported manganese dioxide for fire making at Pech-de-l’Azé I. Whilst the emphasis here has been on the benefits in fire making, the properties of manganese dioxide could have been exploited in other ways, including improved hafting adhesives16. It is not suggested that manganese dioxide was necessary for fire making or used by Neanderthals all over their geographical range. How Neanderthals developed the innovation is unclear. In fact, the methods of fire production in the Middle Palaeolithic have not been identified39 and Neanderthals may only have collected fire from wild fires. However, the fact that fire was used as a tool to produce birch-bark pitch already from the early Middle Palaeolithic onward40,41,42 shows that Neanderthals had the capability to control fire from minimally 200,000 years ago. Such a considerable time depth of fire use would be important to a later recognition of the value of manganese dioxide in fire making. In reviewing the significance of the Female Cosmetic Coalitions (FCC) model in the context of the European Middle Palaeolithic archaeological record, Power, Sommer and Watts8 argue that black “manganese” materials were first present at Pech-de-l’Azé IV and Combe Grenal in the glacial conditions of Marine Isotope Stage (MIS) 4. If analyses shows they are indeed manganese dioxide, these black materials would lend support to an origin in the use of manganese dioxide for fire making in the subsistence challenges of the prolonged cold conditions of MIS 4. Whilst we can envisage substantial subsistence benefits in the ability to better start, promote and control fire, fire use also comes with a wide range of social benefits and implications43. If Neanderthal engagement with materials and processes held subsistence advantages, it may also have been important in the development of complexity in social relationships. Representing fire promotion by manganese dioxide exclusively as a subsistence benefit, no matter how important, risks understating its possible social and symbolic implications43,44, even though these are notoriously difficult to study in the deep past. The selection and use of manganese dioxide for fire making is unknown from the ethnographic record of recent hunter gatherers. This unusual behaviour holds potential significance for our understanding of Neanderthal cognitive capabilities through the extent of their knowledge and insights. The actions involved in the preferential selection of a specific, non-combustible material and its use to make fire are not obvious, not intuitive and unlikely to be discovered by repetitive simple trials as might be expected for lithic fracturing, tool forming and tool use. The knowledge and insights suggested by Neanderthal selection of manganese dioxide and use in fire-making are surprising and qualitatively different from the expertise we associate with Neanderthal subsistence patterns from the archaeological record. We conclude, based on the compositions of the Pech-de-l’Azé I blocs and the availability of different black manganese oxides in the Dordogne region, that Neanderthals were preferentially selecting specifically manganese dioxide blocs. However manganese dioxide does not have clearly evident advantages in decoration over the carbon-rich materials or the other manganese oxides available to Neanderthals. From the combustion and TGA experiments, it is clear that manganese dioxide is an effective facilitator in fire making, reducing the auto-ignition temperature of wood and substantially increasing the rate of combustion. The archaeological evidence of bloc abrasion and grinding stone is consistent with the conversion to powder necessary for use in fire-starting. The intimate association of fire places and manganese dioxide blocs at Pech-de-l’Azé I suggest a use in fire making. We hypothesise that fire-making was manganese dioxide’s most beneficial distinguishing attribute available to Neanderthals. Although we should not exclude the possibility that manganese dioxide was used for decoration and social communication, the combustion, compositional and archaeological strands of evidence lead us to the conclusion that late Neanderthals at Pech-de-l’Azé I were using manganese dioxide in fire-making and by implication were producing fire on demand. Methods Materials Three commercially available manganese dioxide materials were used in the combustion experiments; two reagent grades from Sigma-Aldrich (product reference 310700, coded MD4 and product reference 217646, coded MD6) and a less pure material supplied by Minerals Water Ltd. (coded MD5). A romanèchite, hydrated barium manganese oxide material (coded MD7) from the Schneeberg mine in Saxony, Germany was also used. Its elemental composition is not inconsistent with romanèchite and the XRD-determined structure has close similarities with a romanèchite XRD reference (Supplementary Information 2). This material may not have had precisely the same properties and behaviour as romanèchite material from the Dordogne region. Three metal oxides were chosen for comparative experiments, all thermally stable oxides, aluminium oxide, zinc oxide and titanium dioxide. All the oxide materials were reagent-grade materials from the Gorlaeus Laboratorium, University of Leiden. Elemental compositions and crystal structures of the manganese oxides are given in Supplementary Information 2. Three small blackish coloured blocs from the ‘spoil’ of early twentieth century excavations at Pech-de-l’Azé I were studied (coded MD1, MD2 and MD3). These blocs were recovered during the 2004–5 fieldwork season led by M. Soressi; they were in the excavation spoil at the entrance of the cave along with artefacts left by previous excavators, mostly in L. Capitan and D. Peyrony’s 1912 excavation. Two were grey-black pebble-like materials and the third (MD3) had a more slab-like appearance with a reddish colour overlying the grey-black material on one side. Each bloc was examined by optical and scanning electron microscopy (SEM) with EDX and analyzed by XRD and XRF; approximately two grams in total were used in the combustion experiments. Ten blocs from recorded archaeological contexts in Bordes’ 1970–1 excavations and eleven from Soressi’s 2004–5 excavations were non-destructively analyzed for their XRF compositions and XRD structures. The measured sample set constitutes approximately 5% of the population of blocs when MD1 to MD3 are included. The Bordes’ blocs appeared to have facets or striations suggesting that they had been deliberately abraded. There were no clearly abraded facets on the eleven blocs selected from Soressi’s excavation contexts but there were striations on one bloc. The differences confound two variables, recovery location and apparent use, rendering the interpretation of differences more difficult. The combustible material was untreated beech wood free from bark, converted into turnings using a hand-held electric drill and 22 mm steel bit. Cotton wool and Ulmus sp. seed were used as tinder materials. Combustion Experiments In the combustion experiments, small amounts of the beech wood turnings (1.5 g) or mixtures of beech (1.5 g) with manganese dioxide (0.1 g to 0.5 g) or powdered materials from the Pech-de-l’Azé I blocs or other oxides were placed on a fine steel gauze on a stand within a fume cupboard in a gentle air stream (see Fig. 2). The mixture was heated from below by the flame of a 9.5 cm Sakerhets Tandstickor for fifteen seconds; in some cases the heating time was extended to thirty seconds with a second match. The flame was unable to penetrate the gauze and served to heat the wood via the gauze. For some experiments a Swedish Firesteel 2.0 was used as a source of sparks to light a 0.1 g piece of tinder placed on the surface of the beech turnings. Wherever possible, multiple replication runs were used to validate the outcomes, control runs of beech alone or beech mixed with MD4 or MD6 were used in each phase. In total 120 experimental runs were completed. The effects were recorded on high definition video. In some experiments the whole combustion process of approximately ten minutes was monitored using either a FLIR A35 or a FLIR T450 thermal imaging camera and combustion temperatures recorded. The temperature data were analyzed using FLIR ResearchIR version 3.4 software (Supplementary Information 4). Thermo-gravimetric Analysis Methodology Thermo-gravimetric differential thermal analysis was performed in nitrogen or air atmospheres using a TA-Instruments SDTQ600. A typical sample mass of 12–15 mg was heated to the desired temperature at a ramp rate of 5 °C/min in a total flow rate of 100 ml/min. Beech wood used for the impregnations was ground and sieved to 90 μm. The ground wood (200 mg) was mixed with manganese dioxide to yield 1% by weight, 9% by weight and 23% by weight of manganese dioxide and wood samples. After addition of manganese dioxide the sample was moistened by 1 ml of de-ionized water mixed and oven dried at 60 °C for five hours.
Manganese Sulfate Monohydrate
malic acid; D-Apple Acid; (+-)-Hydroxysuccinic acid; (+-)-Malic acid; Deoxytetraric Acid; Malic acid; 2-Hydroxyethane-1,2-dicarboxylic acid; Deoxytetraric acid; Hydroxybutandisaeure; Hydroxybutanedioic acid; (+-)-Hydroxybutanedioic acid; Hydroxysuccinic acid; Kyselina hydroxybutandiova; Monohydroxybernsteinsaeure; Pomalus acid; R,S(+-)-Malic acid; alpha-Hydroxysuccinic acid; (+-)-1-Hydroxy-1,2-ethanedicarboxylic acid; CAS NO: 6915-15-7
Manganese(II) oxalate dihydrate (MnOx)
mango butter, Mangifera indica seed butter, Cas : 90063-86-8 , EC : 290-045-4
MANGANESE(II) SULFATE
Manganese(II) sulfate is composed of manganese (Mn) in its +2 oxidation state and sulfate ions (SO4^2-).
Manganese(II) sulfate is commonly encountered as the monohydrate MnSO4·H2O, but it can also exist as the anhydrous form (MnSO4) or as other hydrates.
Manganese(II) sulfate is a pale pink, crystalline solid that dissolves readily in water.

CAS Number: 7785-87-7
Molecular Formula: MnO4S
Molecular Weight: 151
EINECS Number: 232-089-9

Manganese sulphate, Manganese(II) sulfate, 7785-87-7, Manganous sulfate, Manganese sulfate anhydrous, Sorba-spray Mn, Man-Gro, Manganese(2+) sulfate, Manganese monosulfate, MnSO4, Sorba-Spray Manganese, 10124-55-7, Manganese(2+) sulfate (1:1), Manganese sulfate (1:1), Manganese sulfate (MnSO4), manganese(2+);sulfate, CCRIS 6916, HSDB 2187, NCI C61143, EINECS 232-089-9, UNII-IGA15S9H40, IGA15S9H40, Manganese(II) sulfate (1:1), EC 232-089-9, MANGANOUS SULFATE ANHYDROUS, MANGANESE SULPHATE ANHYDROUS, MANGANESE SULFATE, ANHYDROUS, MANGANESE SULFATE (ANHYDROUS), MANGANI(II) SULFAS ANHYDRICUS, MANGANESE(2+) SULPHATE (1:1), Sulfuric acid, manganese salt, Sulfato de manganeso, Sulfuric acid, manganese (II) salt (1:1), EINECS 233-342-6, Manganese(II)sulfate, manganese(II) sulphate, manganese(2+) sulphate, MANGANESE (AS SULFATE), MANGANESE SULFATE [MI], DTXSID9044160, CHEBI:86360, Manganese(II) sulfate (MnSO4), DTXSID901015429, MANGANESE SULFATE [WHO-DD], AKOS015904462, MANGANESE (AS SULFATE) [VANDF], MANGANESE SULFATE ANHYDROUS [HSDB], PD077813, M3394, NS00075699.

Manganese(II) sulfate is a moderately water and acid soluble Manganese source for uses compatible with sulfates.
Sulfate compounds are salts or esters of sulfuric acid formed by replacing one or both of the hydrogens with a metal.
Most metal sulfate compounds are readily soluble in water for uses such as water treatment, unlike fluorides and oxides which tend to be insoluble.

Manganese(II) sulfate forms are soluble in organic solutions and sometimes in both aqueous and organic solutions.
Metallic ions can also be dispersed utilizing suspended or coated nanoparticles and deposited utilizing sputtering targets and evaporation materials for uses such as solar cells and fuel cells.
Manganese(II) sulfate is generally immediately available in most volumes.

Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards.
Nanoscale elemental powders and suspensions, as alternative high surface area forms, may be considered.
Typical and custom packaging is available.

Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.
Manganese(II) sulfate is a chemical compound with the formula MnSO4.
Manganese(II) sulfate is also known as manganese sulfate or manganous sulfate.

Manganese(II) sulfate is the manganese salt of sulfate.
Manganese(II) sulfate is an important precursor for the preparation of other manganese metal (e.g. manganese dioxide used in dry-cell batteries) and other chemical compounds.
Manganese(II) sulfate is also an essential trace element which can be supplemented to the soils for plants as well as the feed for animals and livestock.

Manganese(II) sulfate is also a useful trace element for medium of microbes.
Manganese(II) sulfate can be manufactured through the reaction between manganese dioxide and sulfur dioxide or between potassium permanganate with sodium hydrogen sulfate and hydrogen peroxide.
Manganese(II) sulfate is a pink crystalline solid.

Manganese(II) sulfate occurs in nature as several mineral forms, jokokuite, pentahydrite, szmikite, and mallardite.
Manganese(II) sulfate is used in industrial applications such as dyeing, porcelain glazing, and the manufacture of fertilizers and boiling oils.
In biochemistry, Manganese(II) sulfate is found in various superoxide dismutases.

Manganese(II) sulfate is used as a source of manganese ion in biological research, such as in culturing of Bacillus licheniformis and the induction of chromosomal abnormalities in plants.
Manganese(II) sulfate tetrahydrate is an essential mineral used in capsule, tablet and liquid form, which provides essential nutrients like vitamin, protein and in similar nutritional substance.
Manganese(II) sulfate undergoes electrolysis to give manganese dioxide.

Upon oxidation, it gives chemical manganese dioxide (CMD) and finds application in dry- cell batteries.
Manganese(II) sulfate usually refers to the inorganic compound with the formula MnSO4·H2O.
This pale pink deliquescent solid is a commercially significant manganese(II) salt.

Approximately 260,000 tonnes of manganese(II) sulfate were produced worldwide in 2005.
Manganese(II) sulfate is the precursor to manganese metal and many other chemical compounds.
Manganese(II) sulfate soil is remediated with this salt.

Like many metal sulfates, manganese sulfate forms a variety of hydrates: monohydrate, tetrahydrate, pentahydrate, and heptahydrate.
All of these salts dissolve in water to give faintly pink solutions of the aquo complex [Mn(H2O)6]2+.
The structure of MnSO4·H2O has been determined by X-ray crystallography (see figure).

The tetrahydrate also features Manganese(II) sulfate in an O6 coordination sphere provided by bridging two sulfate anions and four aquo ligands.
Typically, Manganese(II) sulfate ores are purified by their conversion to manganese(II) sulfate.
Treatment of aqueous solutions of the sulfate with sodium carbonate leads to precipitation of manganese carbonate, which can be calcined to give the oxides MnOx.

In the laboratory, manganese sulfate can be made by treating manganese dioxide with sulfur dioxide:[4]
MnO2 + SO2 + H2O → MnSO4(H2O)
Manganese(II) sulfate can also be made by mixing potassium permanganate with sodium bisulfate and hydrogen peroxide.

Manganese(II) sulfate is a by-product of various industrially significant oxidations that use manganese dioxide, including the manufacture of hydroquinone and anisaldehyde.
Electrolysis of Manganese(II) sulfate reverses the above reaction yielding manganese dioxide, which is called EMD for electrolytic manganese dioxide.
Alternatively oxidation of manganese sulfate with potassium permanganate yields the so-called chemical manganese dioxide (CMD).

These materials, especially EMD, are used in dry-cell batteries.
Manganese(II) sulfate is the inorganic compound with the formula MnSO4.
This colourless deliquescent solid is a commercially significant manganese(II) salt.

Approximately 260M kg/y were produced worldwide in 2005.
Manganese(II) sulfate is the precursor to manganese metal and many chemical compounds.
Manganese(II) sulfate soil is remediated with this salt.

Manganese(II) sulfate is the sulfate salt of manganese, with the formula MnSO4.
Although the anhydrous salt is white, its hydrates are pinkish in color.
Manganese(II) sulfate will precipitate as manganese hydroxide when mixed with a strong base, such as sodium hydroxide.

Manganese(II) sulfate is a pinkish crystalline salt, soluble in water, as well as primary alcohols, though insoluble in aprotic solvents, such as benzene or diethyl ether.
Manganese(II) sulfate is most often encountered as monohydrate form, though other hydrates, like tetrahydrate, pentahydrate, and heptahydrate also exist.
Manganese(II) sulfate is sold by various chemical suppliers.

Manganese(II) sulfate monohydrate is available as fertilizer and can be found in many gardening stores, or online.
Manganese(II) sulfate tetrahydrate is an essential mineral used in capsule, tablet and liquid form, which provides essential nutrients like vitamin, protein and in similar nutritional substance.
Manganese(II) sulfate undergoes electrolysis to give manganese dioxide.

Upon oxidation, it gives chemical manganese dioxide (CMD) and finds application in dry- cell batteries.
Manganese(II) sulfate, also known as manganous sulfate, is a chemical compound.
Manganese(II) sulfate contains manganese in its +2 oxidation state.

Manganese(II) sulfate contains manganese and sulfate ions.
Its chemical formula is MnSO4.
Manganese(II) sulfate is a pink crystalline solid.

Manganese(II) sulfate normally is bonded with some water molecules.
Manganese(II) sulfate is part of a process to make manganese metal.
Manganese(II) sulfate can be made separately though.

If sulfur dioxide and manganese dioxide are reacted, it produces manganese(II) sulfate.
Manganese(II) sulfate reacts with potassium permanganate to make manganese dioxide.
Manganese(II) sulfate is used to add manganese to soil.

Manganese(II) sulfate is a chemical compound with the formula MnSO4.
Manganese(II) sulfate appears as a white crystalline solid that can be dissolved in water to form a blue solution.
Manganese(II) sulfate is used as an experimental solubility data for other compounds and it has been shown to have antimicrobial properties.

Manganese(II) sulfate is also used in the production of phosphate fertilizers, as it has been shown to inhibit enzymes that catalyze the conversion of phosphates into orthophosphates.
Manganese(II) sulfate reacts with citrate ions to produce manganous citrate, which can then react with hydrogen peroxide to form manganous peroxide.
This reaction mechanism may be responsible for the formation of manganese oxide, which is used in the manufacture of zirconium oxide.

Manganese(II) sulfate usually refers to the inorganic compound with the formula MnSO4-H2O.
This pale pink solid is a commercially important salt of manganese (II).
Manganese(II) sulfate is the precursor of manganese metal and many other chemical compounds.

In dry type batteries, Manganese(II) sulfate is produced from manganese sulfate by electrolysis, called electrolytic manganese dioxide (EMD).
When Manganese(II) sulfate is oxidized with potassium permanganate, so-called chemical manganese dioxide (CMD) is produced.
These materials, in particular EMD, are used in dry cell batteries.

In agriculture, Manganese(II) sulfate is used for manganese deficiency or prophylaxis.
Manganese(II) sulfate deficiency is a plant disorder that is often confused with, and occurs in association with, iron deficiency.
Manganese(II) sulfate is most common in swampy soils and where organic matter content is high.

Manganese(II) sulfate may be unavailable to plants with high pH.
Onions, apples, peas, French beans, cherries and raspberries may be affected by deficiency, with symptoms including yellowing leaves with small areas of green.
The plant may appear healthy as new leaf growth may appear normal.

Brown spots on the leaf surfaces may occur and severely affected leaves will turn brown and die back.
Manganese(II) sulfate is a salt that is typically produced by the reaction of manganese dioxide (MnO2) with sulfuric acid (H2SO4).
Manganese(II) sulfate is soluble in water, and its aqueous solution is acidic.

Manganese(II) sulfate can form various hydrates, with the monohydrate (MnSO4·H2O) being the most common form.
Manganese(II) sulfate is primarily used in industrial processes such as metal finishing, textile dyeing, and the production of fertilizers and animal feed supplements.
Manganese(II) sulfate is also employed in the manufacturing of ceramics, paints, inks, and other chemical products.

In agriculture, manganese(II) sulfate is utilized as a micronutrient fertilizer to address manganese deficiency in soils.
Manganese(II) sulfate is an essential trace element for plants, playing a vital role in photosynthesis, enzyme activation, and overall plant growth and development.
Manganese(II) sulfate is commonly used as a reagent in laboratory experiments and chemical analyses.

Manganese(II) sulfate can serve as a source of manganese ions in various reactions and synthesis processes, particularly those involving coordination chemistry and redox reactions.
Manganese(II) sulfate solutions are employed in electroplating processes to deposit manganese coatings onto metal surfaces.
These coatings provide corrosion resistance, improve surface hardness, and enhance the aesthetic appearance of the plated materials.

Manganese(II) sulfate is a key component in the production of dry-cell batteries, such as alkaline batteries and lithium-ion batteries.
Manganese(II) sulfate is utilized as an electrolyte additive to enhance battery performance and longevity.
Manganese(II) sulfate is an essential nutrient for human health, playing roles in metabolism, bone formation, and antioxidant defense.

While manganese sulfate itself is not typically consumed directly as a nutritional supplement, it contributes to the manganese content in food and feed products.
Like other metal sulfates, manganese(II) sulfate can pose environmental risks if released into the environment in large quantities.
Proper handling, storage, and disposal practices are necessary to prevent contamination of soil, water, and air.

Manganese(II) sulfate is subject to regulations and guidelines governing its production, handling, transportation, and use.
Regulatory agencies such as the Environmental Protection Agency (EPA) and the Occupational Safety and Health Administration (OSHA) establish standards to ensure its safe manufacture and application.

Melting point: 700°C
Boiling point: decomposes at 850℃ [HAW93]
Density: 3.250
vapor pressure: 0Pa at 20℃
form: white orthorhombic crystals
color: white orthorhombic crystals, crystalline
Water Solubility: g/100g solution H2O: 34.6 (0°C), 39.2 (25°C), 26.1 (100.7°C); solid phase, MnSO4 · 7H2O (0°C), MnSO4 ·H2O (25°C, 100.7°C) [KRU93]
LogP: -1.031 (est)

Manganese(II) sulfate minerals are very rare in nature and always occur as hydrates.
The monohydrate is called szmikite; the tetrahydrate is called ilesite; the pentahydrate is called jōkokuite; the hexahydrate, the most rare, is called chvaleticeite; and the heptahydrate is called mallardite.
A metal sulfate in which the metal component is manganese in the +2 oxidation state.

Also known as manganous sulfate, MnS04,4H20 is water-soluble, translucent, efflorescent rose-red prisms which melt at 30°C.
Manganese(II) sulfate is used in medicine,textile printing,and ceramics,as a fungicide and fertilizer, and in paint manufacture.
Manganese(II) sulfate usually refers to the inorganic compound with the formula MnSO4·H2O.

This pale pink deliquescent solid is a commercially significant manganese(II) salt.
Approximately 260,000 tonnes of manganese(II) sulfate were produced worldwide in 2005.
Manganese(II) sulfate is the precursor to manganese metal and many other chemical compounds.

Manganese-deficient soil is remediated with this salt.
Manganese(II) sulfate usually refers to the inorganic compound with the formula MnSO4·H2O.
This pale pink deliquescent solid is a commercially significant manganese(II) salt.

Approximately 260,000 tonnes of manganese(II) sulfate were produced worldwide in 2005.
Manganese(II) sulfate is the precursor to manganese metal and many other chemical compounds.
Manganese-deficient soil is remediated with this salt.

Manganese(II) sulfate monohydrate acts as a colorant in dyes.
Manganese(II) sulfate is used in the preparation of manganese and manganese dioxide.
Manganese(II) sulfate finds application for remediation of manganese-deficient soil.

Manganese(II) sulfate is also used in dry-cell batteries.
Manganese(II) sulfate contains one Manganese (Mn), one Sulfur (S), and four Oxygen (O) atoms.
Manganese(II) sulfate is a chemical compound with atomic number 25 in the periodic table.

Sulfur (S) is a chemical element with the atomic number 16 in the periodic table.
Oxygen (O) is the chemical element with atomic number 8 in the periodic table.
The chemical formula of Manganese(II) sulfate is MnSO4.

Manganese(II) sulfate contains one Manganese (Mn), one Sulfur (S), and four Oxygen (O) atoms.
This chemical compound is a metal sulfate.
Manganese(II) sulfate is also called Manganese Sulfate or Manganous Sulfate.

In this, manganese has a +2 oxidation state.
Manganese(II) sulfate looks like white crystals in its anhydrous form, and it is pale pink color solid in its hydrate form.
Manganese(II) sulfate is a hydrated manganese salt.

The neurological response caused in rhesus monkeys due to MnSO4 exposure have been studied.
The limiting molar conductance and association constant of MnSO4 dissolved in aqueous Manganese(II) sulfate have been determined.
The solubility, binary interaction parameters and solubility parameters were obtained for aqueous solution containing manganese sulfate monohydrate and magnesium sulfate.

Manganese Sulfate is generally considered unsafe because the chemical is toxic.
Exposure to this chemical can have acute health effects.
According to the MSDS of Manganese Sulfate, it can cause serious eye infection.

Manganese(II) sulfate may cause damage to organs through prolonged or repeated exposure.
Manganese(II) sulfate is toxic to aquatic life with long lasting effects.
Proper storage and disposal of Manganese(II) sulfate needs to be taken into consideration in order to avoid any unwanted effects.

Manganese(II) sulfate is involved in various oxidation-reduction reactions due to the ability of manganese ions to change oxidation states.
Manganese(II) sulfate can undergo oxidation to form higher oxidation states of manganese, such as manganese(III) and manganese(IV), in chemical processes and reactions.
In analytical chemistry, manganese(II) sulfate is used as a standard reference material and as a reagent for qualitative and quantitative analysis.

Manganese(II) sulfate can be employed in titration methods, colorimetric assays, and spectroscopic techniques to determine the concentration of specific substances in solution.
Manganese(II) sulfate crystals have been studied for their crystallographic properties and growth patterns.
Understanding the crystallization behavior of manganese(II) sulfate and related compounds is important for crystallography research and materials science applications.

While manganese(II) sulfate itself is not commonly used as a therapeutic agent, manganese compounds have been investigated for potential medicinal properties.
Research suggests that manganese may play a role in certain biological processes and could have applications in pharmaceutical formulations and medical treatments.
Manganese(II) sulfate is sometimes used in water treatment processes, particularly for the removal of certain contaminants and impurities.

Manganese(II) sulfate can aid in the precipitation and removal of metals, such as iron and arsenic, from water sources through chemical precipitation or coagulation.
In the dyeing and textile industry, manganese(II) sulfate is utilized as a mordant—a substance that helps fix dyes to fabrics and enhances their colorfastness.
Manganese mordants can impart vibrant and long-lasting colors to textiles, contributing to the production of dyed fabrics and garments.

Manganese(II) sulfate is added to animal feed formulations as a nutritional supplement to address manganese deficiency in livestock and poultry.
Adequate manganese intake is essential for the health and growth of animals, and manganese sulfate serves as a cost-effective source of this essential mineral in feed additives.
Manganese(II) sulfate is used in biological and environmental research studies to investigate the behavior of manganese ions in biological systems, soil chemistry, and aquatic environments.

These studies help elucidate the role of manganese in ecosystems and its impact on living organisms.
Manganese(II) sulfate solutions are employed in electrochemical studies and experiments to investigate the electrochemical behavior of manganese ions and their applications in batteries, fuel cells, and electroplating processes.
Such studies contribute to the advancement of electrochemistry and energy storage technologies.

Uses:
Manganese(II) sulfate is used primarily as a fertilizer and as livestock supplement where soils are deficient in manganese, then in some glazes, varnishes, ceramics, and fungicides.
Manganese(II) sulfate is a granulated manganese fertiliser for dry application to the soil.
Manganese(II) sulfate is also used as an ingredient in blended fertilisers.

Manganese(II) sulfate is primarily intended for use in South Australia in planting fertilisers in crops grown on calcareous soils.
Manganese deficiency most commonly occurs on alkaline (high pH) soils.
Manganese is quite abundant in the soil.

Deficiency occurs because manganese is tied up or fixed in the soil in forms not available for plant uptake, i.e. at high pH, not because the soil is low in manganese.
Manganese applied as fertiliser can be rapidly converted to plant-unavailable forms.
For this reason, Manganese(II) sulfate is recommended that manganese be applied as foliar sprays where practicable, rather than to the soil.

In horticultural crops, manganese can be applied with routine crop protection sprays.
Manganese(II) sulfate is used in the production of dry-cell batteries, such as alkaline batteries and lithium-ion batteries.
Manganese(II) sulfate serves as an electrolyte additive to improve battery performance and longevity. Manganese compounds contribute to the electrochemical processes within the battery, enhancing its efficiency and energy storage capacity.

Manganese(II) sulfate crystals have applications in crystallography research and materials science.
Understanding the crystallization behavior of manganese(II) sulfate and related compounds is important for studying crystal growth mechanisms, crystal structure determination, and crystallographic analysis techniques.
Manganese(II) sulfate is employed as a reagent in analytical chemistry for qualitative and quantitative analysis.

Manganese(II) sulfate can be used in titration methods, colorimetric assays, and spectroscopic techniques to determine the concentration of specific substances in solution.
Manganese(II) sulfate solutions may also serve as standard reference materials in analytical laboratories.
Manganese is an essential trace element for human health, and manganese(II) sulfate contributes to manganese intake in food and dietary supplements.

Adequate manganese intake supports various biological functions, including metabolism, bone formation, and antioxidant defense.
While manganese(II) sulfate is not typically consumed directly as a nutritional supplement, it contributes to overall manganese levels in the diet.
Manganese(II) sulfate may be used in environmental remediation efforts to treat contaminated soil and groundwater.

Manganese(II) sulfate can assist in the removal of heavy metals and other pollutants through precipitation or adsorption processes.
Manganese compounds can help mitigate the environmental impact of industrial activities and pollution sources.
Manganese(II) sulfate has historical significance in photography as a component of certain developing solutions.

While its use in photography has diminished with the advent of digital imaging technologies, manganese compounds were once used in the processing of photographic film and prints.
Manganese(II) sulfates, including manganese(II) sulfate, have applications as catalysts in chemical reactions.
They can facilitate various organic transformations, such as oxidation, reduction, and carbon-carbon bond formation.

Manganese-based catalysts are studied for their potential use in industrial processes and green chemistry applications.
Manganese(II) sulfate has been used as a micronutrient for preparation of nutritive medium for growth of sugarcane plantlets.
Manganese(II) sulfate has also been used as a trace element in the preparation of N6 complete nutrient liquid medium for growing mycelia of H. cylindrosporum.

Manganese(II) sulfate is an essential mineral used in capsule, tablet and liquid form, which provides essential nutrients like vitamin, protein and in similar nutritional substance.
Manganese(II) sulfate undergoes electrolysis to give manganese dioxide.
Upon oxidation, Manganese(II) sulfate gives chemical manganese dioxide (CMD) and finds application in dry- cell batteries.

Manganese(II) sulfate is used to produce manganese by an electrolytic process.
The compound is used for dyeing textiles; for producing red glazes on porcelain; in varnish driers; in fertilizers; and in animal feeds to provide manganese as an essential trace element.
Manganese(II) sulfate is a source of manganese that functions as a nutrient and dietary supplement.

Manganese(II) sulfate exists as a powder which is readily soluble in water.
Manganese(II) sulfate monohydrate is used as a colorant in dyes, fertilizers, animal feeds and red glazes on porcelain.
Further, Manganese(II) sulfate is used in paints, ceramics, nutrient and dietary supplement.

Manganese(II) sulfate is involved in the preparation of manganese dioxide.
In addition, Manganese(II) sulfate serves as a precursor to manganese metal and other manganese compounds.
In medicine, Manganese(II) sulfate is used to regulate plasma manganese concentrations and the depletion of endogenous stores.

In laboratories, Manganese(II) sulfate is used in the reduction reaction by mixing ethanol and hydrogen peroxide together.
Manganese(II) sulfate decomposes hydrogen peroxide into oxygen and water, which vaporizes ethanol. When the vapor is ignited, it produces a very effective flame because the ethanol vapor no longer needs to mix with the air.
Manganese(II) sulfate is commonly used as a micronutrient fertilizer to correct manganese deficiency in crops and soils.

Manganese(II) sulfate is an essential element for plant growth and development, playing a crucial role in photosynthesis, enzyme activation, and nutrient uptake.
In industrial settings, manganese(II) sulfate is utilized in processes such as metal finishing, textile dyeing, and the production of ceramics and batteries.
Manganese(II) sulfate serves as a source of manganese ions for various chemical reactions and synthesis processes.

Manganese(II) sulfate solutions are used in electroplating processes to deposit manganese coatings onto metal surfaces.
These coatings provide corrosion resistance, improve surface hardness, and enhance the aesthetic appearance of the plated materials.
Manganese(II) sulfate is employed as a reagent in laboratory experiments and chemical analyses, particularly in coordination chemistry and redox reactions.

Manganese(II) sulfate can serve as a source of manganese ions for various research purposes.
Manganese(II) sulfate is added to animal feed formulations as a nutritional supplement to address manganese deficiency in livestock and poultry.
Adequate manganese intake is essential for animal health, growth, and reproduction.

Manganese(II) sulfate may be used in water treatment processes to remove certain contaminants and impurities, such as iron and arsenic, from water sources.
Manganese(II) sulfate can aid in the precipitation and removal of metals through chemical precipitation or coagulation.
In the dyeing and textile industry, manganese(II) sulfate is employed as a mordant—a substance that helps fix dyes to fabrics and enhances their colorfastness.

Manganese mordants contribute to vibrant and long-lasting colors in dyed textiles.
While not a direct application, manganese compounds, including manganese(II) sulfate, are studied in medicinal research for potential therapeutic properties.
Research suggests that manganese may play a role in certain biological processes and could have applications in pharmaceutical formulations and medical treatments.

Safety Profile:
Poison by intraperitoneal route.
Questionable carcinogen with experimental neoplas tigenic data.
An experimental teratogen.

Experimental reproductive effects.
Mutation data reported.
When heated to decomposition it emits toxic fumes of SO2, so3, and Mn oxides.

Direct contact with manganese(II) sulfate may cause skin irritation, especially in individuals with sensitive skin or prolonged exposure.
This can result in redness, itching, or dermatitis.
Manganese(II) sulfate is important to wear appropriate protective clothing, such as gloves and long sleeves, when handling manganese(II) sulfate to prevent skin contact.

Manganese(II) sulfate can cause irritation and damage to the eyes upon contact.
This may result in redness, pain, and blurred vision.
In case of eye contact, it is crucial to immediately flush the eyes with plenty of water for at least 15 minutes while keeping the eyelids open.

Seek medical attention if irritation persists.
Inhalation of manganese(II) sulfate dust or aerosols may irritate the respiratory tract and cause respiratory discomfort.

Prolonged or repeated exposure to airborne manganese(II) sulfate particles may lead to respiratory irritation, coughing, or difficulty breathing.
Adequate ventilation and respiratory protection, such as dust masks, should be used to minimize inhalation exposure.



Mangifera indica
mangifera indica fruit extract; mango fruit extract; extrapone mango milk ; extract of the fruit of the mango, mangifera indica l., anacardiaceae CAS NO: 90063-86-8
mango butter ( Beurre de mangue)
MANNITOL; D-(+)-Mannitol; Isotol; 1,2,3,4,5,6-Hexanehexol; Diosmol; Cordycepic acid; D-mannite; Osmosal; Hexitol; Mannazucker (German); D-mannitol; Manicol; Manita; Manna sugar; Mannidex; Mannite; Osmitrol; cas no: 87-78-5, 69-65-8
MANNITOL
MANNITOL = d-MANNITOL, MANNITE, MANNA SUGAR


CAS Number: 69-65-8
EC Number: 200-711-8
MDL Number: MFCD00064287
E number: E421
Molecular Formula: C6H14O6


Mannitol is in the form of white crystalline powder in physical appearance.
Mannitol can also be found in the form of granules.
Mannitol has a sweet characteristic in taste.
Mannitol has scent.


Mannitol's melting point is 168 °C.
Mannitol's boiling point is between 290 °C and 295 °C.
Mannitol solubility is 216 g/Lt at 25 °C.
The solubility of Mannitol increases as the temperature increases.


Mannitol's density is 1.52 gr/cm³ at 20 °C.
Mannitol is a diuretic.
Mannitol has 50% more sweetness than sucrose.
Mannitol is a naturally occurring substance in fruits and vegetables.


Mannitol does not have caryonegic properties.
Mannitol is a hexahydric alcohol derivative.
Mannitol is also found in mushrooms.
Mannitol's task in such areas is as sugar and carbohydrate reserves.


Mannitol is a derivative of the sorbitol compound.
Mannitol's E Code is E 421.
Mannitol’s safety has been reviewed and confirmed by health authorities around the world, including the World Health Organization, the European Union, and the countries Australia, Canada and Japan. The U.S. Food and Drug Administration (FDA) also recognizes mannitol as safe.


Mannitol is a sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables.


Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma.
As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced.
The discovery of mannitol is attributed to Joseph Louis Proust in 1806.


It is on the World Health Organization's List of Essential Medicines.
Mannitol was originally made from the flowering ash and called manna due to its supposed resemblance to the Biblical food.
Mannitol is a naturally occurring alcohol found in fruits and vegetables and used as an osmotic diuretic.
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables.


Mannitol appears as odorless white crystalline powder or free-flowing granules.
Mannitol is an osmotic diuretic.
Mannitol is a sugar alcohol that is easily soluble in water and is a white crystalline powder with a sweet taste similar to sucrose.
Mannitol is a type of carbohydrate called a sugar alcohol, or polyol.


Mannitol contains about 60 percent fewer calories than sugar and is half as sweet.
Mannitol occurs naturally in fresh mushrooms, brown algae, tree bark and most fruits and vegetables.
Mannitol is commercially produced for use in chocolate coatings, confections and chewing gum.
Mannitol’s safety has been confirmed by global health authorities.


Mannitol (pronounced ma-nuh-tall) is a type of carbohydrate called a sugar alcohol, or polyol, which are water-soluble compounds that occur naturally in many fruits and vegetables. Mannitol is also commercially produced for use in chocolate coatings, confections, chewing gums, powders and tablets to provide body, sweetness, cooling taste and texture.
Mannitol’s also useful as an anti-caking agent due to its minimal ability to absorb water.



USES and APPLICATIONS of MANNITOL:
In the pharmaceutical industry, Mannitol is used as a basic ingredient in the manufacture of chewable tablets due to its non-hygroscopic properties.
Mannitol is used in the manufacture of drug-containing chewing gums.
Mannitol is used as a sweetening agent.


Mannitol is used in the manufacture of drugs produced to treat swelling around the brain and inside the eyes.
Some people have trouble producing urine in their body. Mannitol is used in the manufacture of drugs used to make the body produce urine.
Medicines containing this chemical are given to treat patients with kidney failure.
Thanks to these drugs, excess water and toxic substances in the body are eliminated.


Mannitol is used in the manufacture of these drugs.
Mannitol is used as an anti-caking agent in the food industry.
Mannitol is used as a flavoring agent in the production of nuts.
Sugar alcohols used in the production of antifreeze, namely alcohols such as Mannitol, dextrose, maltitol, sorbitol.


With the increase of Dextrose Equivalent, Mannitol will increase water activity and inhibition of water crystallization.
This will lower the freezing point.
Mannitol is used as a flavor enhancer.
In vehicle engines , Mannitol is used in very small amounts together with Mono Ethylene Glycol as an anti-wear chemical.


Mannitol is a diuretic that is used to reduce swelling and pressure inside the eye or around the brain.
Mannitol is also used to help your body produce more urine.
Mannitol is used in people with kidney failure, to remove excess water and toxins from the body.
Mannitol is sometimes given so that your body will produce enough urine to be collected and tested.


This helps your doctor determine if your kidneys are working properly.
Mannitol may also be used for purposes not listed in this medication guide.
Mannitol is a diuretic.
Mannitol helps you make more urine and to lose salt and excess water from your body.


Mannitol treats swelling from heart, kidney, or liver disease.
Mannitol also treats swelling around the brain or in the eyes.
Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid.


Mannitol is used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
Mannitol causes an osmotic shift of water into the vascular space, decreases blood viscosity, and increases cerebral blood flow and oxygen delivery.


Mannitol is a diuretic used to force urine production in people with acute (sudden) kidney failure.
Mannitol injection is also used to reduce swelling and pressure inside the eye or around the brain.
Mannitol inhalation is used in patients 6 years of age and older to help diagnose asthma.
Mannitol is used in a procedure called bronchial challenge test to help your doctor measure the effect of this medicine on your lungs and check if you have difficulty with breathing.


Mannitol inhalation is also used as an add-on maintenance treatment to improve lung function in patients with cystic fibrosis.
Mannitol is also indicated as add-on maintenance therapy for improving pulmonary function in cystic fibrosis patients aged 18 and over who have passed the BRONCHITOL tolerance test (BTT).
Mannitol is recommended that patients take an orally inhaled short-acting bronchodilator 5-15 minutes prior to every inhaled mannitol dose.


Mannitol acts as an osmotic laxative in oral doses larger than 20 g, and is sometimes sold as a laxative for children.
Mannitol is commonly used in the circuit prime of a heart lung machine during cardiopulmonary bypass.
The presence of mannitol preserves renal function during the times of low blood flow and pressure, while the patient is on bypass.


Mannitol can also be used to temporarily encapsulate a sharp object (such as a helix on a lead for an artificial pacemaker) while it passes through the venous system.
Because the mannitol dissolves readily in blood, the sharp point becomes exposed at its destination.


Mannitol is also the first drug of choice to treat acute glaucoma in veterinary medicine.
Mannitol is administered as a 20% solution intravenously.
Mannitol dehydrates the vitreous humor and, therefore, lowers the intraocular pressure.
However, Mannitol requires an intact blood-ocular barrier to work.


Mannitol is a type of sugar alcohol used as a sweetener and medication.
Mannitol is used as a low calorie sweetener as it is poorly absorbed by the intestines.
As a medication, it is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure.
Medically, Mannitol is given by injection or inhalation.


Effects typically begin within 15 minutes and last up to 8 hours.
Mannitol is the primary ingredient of mannitol salt agar, a bacterial growth medium, and is used in others.
Mannitol is used as a cutting agent in various drugs that are used intranasally (snorted), such as cocaine.
A mixture of mannitol and fentanyl (or fentanyl analogs) in ratio 1:10 is labeled and sold as "China white", a popular heroin substitute.


Mannitol is freely filtered by the glomerulus and poorly reabsorbed from the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate.
An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis.


In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow of water from tissues into interstitial fluid and plasma.
Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma.
As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced.


Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid.
Mannitol, a hypertonic and hyperosmolar diuretic, increases the osmolarity of the plasma when administered intravenously, increasing the passage of water into the plasma from tissues including the brain, cerebrospinal fluid and eye.


In this way, Mannitol reduces the fluid volume and pressure in the tissues.
Therefore, Mannitol is widely used as an osmotic diuretic in neurosurgical operations, as well as in clinical situations where intracranial pressure is increased.
Mannitol is a sugar alcohol that can be used as an anti-caking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer, thickener and nutritive sweetener in food industry.


Mannitol is a type of sugar alcohol which is also used as a medication.
As a sugar, Mannitol is often used as a sweetener in diabetic food, as it is poorly absorbed from the intestines.
As a medication, Mannitol is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure.
Medically, Mannitol is given by injection.
Effects typically begin within 15 minutes and last up to 8 hours.


-Therapeutic Use:
*Increasing urine output for the prevention or treatment of the oliguric phase of acute renal failure without the occurrence of irreversible renal failure.
*Reduction of intracranial pressure and treatment of cerebral edema,
*Pressure reduction when increased intraocular pressure cannot be reduced by other means
*To increase the urinary excretion of toxic substances and in the irrigation of the urinary tract.
*It is appropriate to use Mannitol only in patients with CIBAS.


-Contraindications:
Mannitol is contraindicated in people with anuria, severe hypovolemia, pre-existing severe pulmonary vascular congestion or pulmonary edema, irritable bowel syndrome (IBS), and active intracranial bleeding except during craniotomy.


-Chemistry:
Mannitol is an isomer of sorbitol, another sugar alcohol; the two differ only in the orientation of the hydroxyl group on carbon 2.
While similar, the two sugar alcohols have very different sources in nature, melting points, and uses.


-Food:
Mannitol increases blood glucose to a lesser extent than sucrose (thus having a relatively low glycemic index) so is used as a sweetener for people with diabetes, and in chewing gums.
Although mannitol has a higher heat of solution than most sugar alcohols, its comparatively low solubility reduces the cooling effect usually found in mint candies and gums.
However, when mannitol is completely dissolved in a product, it induces a strong cooling effect.
Also, it has a very low hygroscopicity – it does not pick up water from the air until the humidity level is 98%.
This makes mannitol very useful as a coating for hard candies, dried fruits, and chewing gums, and it is often included as an ingredient in candies and chewing gum.
The pleasant taste and mouthfeel of mannitol also makes it a popular excipient for chewable tablets.


-Medical uses:
In the United States, mannitol is indicated for the reduction of intracranial pressure and treatment of cerebral edema and elevated intraocular pressure.
In the European Union, mannitol is indicated for the treatment of cystic fibrosis (CF) in adults aged 18 years and above as an add-on therapy to best standard of care.
Mannitol is used intravenously to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., after head trauma.
While mannitol injection is the mainstay for treating high pressure in the skull after a bad brain injury, it is no better than hypertonic saline as a first-line treatment.
In treatment-resistant cases, hypertonic saline works better.
Mannitol may also be used for certain cases of kidney failure with low urine output, decreasing pressure in the eye, to increase the elimination of certain toxins, and to treat fluid build up.
Intraoperative mannitol prior to vessel clamp release during renal transplant has been shown to reduce post-transplant kidney injury, but has not been shown to reduce graft rejection.


-Analytical chemistry:
Mannitol can be used to form a complex with boric acid.
This increases the acid strength of the boric acid, permitting better precision in volumetric analysis of this acid.



FUNCTIONS OF MANNITOL:
1.Pharmaceutical Industry: Antihypertensive reagent,diuretic,dehydrating reagent,laxative lapactic;Excipient and filler for tablets.Synthesize mannitol oleic ester.
2. Food Industry:
Sweetener in sugar free chewing gum Chlcolate coat of ice cream and sugar Beverage,sytup and other food"
3. Toothpaste industry instead of glycerol
4. Synthesize mannitol rigid poly urethane foam
5. Synthesize mannitol oleate
6. Electronic solution for electrolytic capacitor



HOW IS MANNITOL PRODUCED?
There are several methods for the production of Mannitol. Among them, Mannitol is obtained by reduction of glucose by electrolytic method or by hydrogenation of invert sugar, monosaccharides or sucrose.
Mannitol's commercial production is produced by the catalytic or electrolytic reduction of monosaccharides such as glucose or mannose.

Mannitol is the chemical 1,2,3,4,5,6,-hexanehexol (C6H14O6) a hexahydric alcohol, differing from sorbitol principally by having a different optical rotation.
Mannitol is produced by one of the following processes:

(1) The electrolytic reduction or transition metal catalytic hydrogenation of sugar solutions containing glucose or fructose.
(2) The fermentation of sugars or sugar alcohols such as glucose, sucrose, fructose, or sorbitol using the yeast Zygosaccharomyces rouxii.
(3) A pure culture fermentation of sugars such as fructose, glucose, or maltose using the nonpathogenic, nontoxicogenic bacterium Lactobacillus intermedius (fermentum).

Mannitol is classified as a sugar alcohol; that is, it can be derived from a sugar (mannose) by reduction.
Other sugar alcohols include xylitol and sorbitol.
Mannitol and sorbitol are isomers, the only difference being the orientation of the hydroxyl group on carbon 2.



PHARMACODYNAMICS OF MANNITOL:
Chemically, Mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol.
However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic.
For this reason, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate.
Mannitol is commonly used to increase urine production (diuretic).
Mannitol is also used to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure).
Mannitol is frequently given along with other diuretics (e.g., furosemide, chlorothiazide) and/or IV fluid replacement.



MECHANISM OF ACTION OF MANNITOL:
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables.
Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma.

As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced.
As a diurectic mannitol induces diuresis because it is not reabsorbed in the renal tubule, thereby increasing the osmolality of the glomerular filtrate, facilitating excretion of water, and inhibiting the renal tubular reabsorption of sodium, chloride, and other solutes.

Mannitol promotes the urinary excretion of toxic materials and protects against nephrotoxicity by preventing the concentration of toxic substances in the tubular fluid.
As an Antiglaucoma agent mannitol levates blood plasma osmolarity, resulting in enhanced flow of water from the eye into plasma and a consequent reduction in intraocular pressure.
As a renal function diagnostic aid mannitol is freely filtered by the glomeruli with less than 10% tubular reabsorption. Therefore, its urinary excretion rate may serve as a measurement of glomerular filtration rate (GFR).

*increases the osmolarity of the glomerular filtrate -> *increasing urinary volume
*decreases CSF volume and pressure by
*decreasing rate of CSF production
*withdrawing brain extracellular water across the BBB into plasma



INDUSTRIAL SYNTHESIS OF MANNITOL:
Mannitol is commonly produced via the hydrogenation of fructose, which is formed from either starch or sucrose (common table sugar).
Although starch is a cheaper source than sucrose, the transformation of starch is much more complicated.
Eventually, it yields a syrup containing about 42% fructose, 52% glucose, and 6% maltose.
Sucrose is simply hydrolyzed into an invert sugar syrup, which contains about 50% fructose.
In both cases, the syrups are chromatographically purified to contain 90–95% fructose.
The fructose is then hydrogenated over a nickel catalyst into a mixture of isomers sorbitol and mannitol.
Yield is typically 50%:50%, although slightly alkaline reaction conditions can slightly increase mannitol yields.



BIOSYNTHESES OF MANNITOL:
Mannitol is one of the most abundant energy and carbon storage molecules in nature, produced by a plethora of organisms, including bacteria, yeasts, fungi, algae, lichens, and many plants.
Fermentation by microorganisms is an alternative to the traditional industrial synthesis.

A fructose to mannitol metabolic pathway, known as the mannitol cycle in fungi, has been discovered in a type of red algae (Caloglossa leprieurii), and it is highly possible that other microorganisms employ similar such pathways.
A class of lactic acid bacteria, labeled heterofermentive because of their multiple fermentation pathways, convert either three fructose molecules or two fructose and one glucose molecule into two mannitol molecules, and one molecule each of lactic acid, acetic acid, and carbon dioxide.

Feedstock syrups containing medium to large concentrations of fructose (for example, cashew apple juice, containing 55% fructose: 45% glucose) can produce yields 200 g (7.1 oz) mannitol per liter of feedstock.
Further research is being conducted, studying ways to engineer even more efficient mannitol pathways in lactic acid bacteria, as well as the use of other microorganisms such as yeast and E. coli in mannitol production.
When food-grade strains of any of the aforementioned microorganisms are used, the mannitol and the organism itself are directly applicable to food products, avoiding the need for careful separation of microorganism and mannitol crystals.
Although this is a promising method, steps are needed to scale it up to industrially needed quantities.



NATURAL EXTRACTION OF MANNITOL:
Since mannitol is found in a wide variety of natural products, including almost all plants, it can be directly extracted from natural products, rather than chemical or biological syntheses.
In fact, in China, isolation from seaweed is the most common form of mannitol production.
Mannitol concentrations of plant exudates can range from 20% in seaweeds to 90% in the plane tree.
Mannitol is a constituent of saw palmetto (Serenoa).
Traditionally, mannitol is extracted by the Soxhlet extraction, using ethanol, water, and methanol to steam and then hydrolysis of the crude material.

The mannitol is then recrystallized from the extract, generally resulting in yields of about 18% of the original natural product.
Another method of extraction is using supercritical and subcritical fluids.
These fluids are at such a stage that no difference exists between the liquid and gas stages, so are more diffusive than normal fluids.
This is considered to make them much more effective mass transfer agents than normal liquids.
The super- or subcritical fluid is pumped through the natural product, and the mostly mannitol product is easily separated from the solvent and minute amount of byproduct.



MANNITOL AND HEALTH:
Like most sugar alcohols, mannitol is neither as sweet as nor as calorie–dense as sugar.
Mannitol is about half as sweet as sugar and has about 60 percent fewer calories per gram (1.6 calories for mannitol compared to 4 calories for sugar).
But mannitol’s contributions to health go beyond calories.
Two areas in which sugar alcohols are known for their positive effects are oral health and impact on blood sugar.



ORAL HEALTH:
Sugar alcohols, including mannitol, have been shown to benefit oral health in several ways.
Primarily, they are considered “tooth-friendly” because they are noncariogenic: in other words, they don’t contribute to cavity formation.
The act of chewing also protects teeth from cavity-causing bacteria by promoting the flow of saliva.
The increased saliva and noncariogenic properties (along with sweetness and cool taste) are why sugar alcohols like maltitol, mannitol, sorbitol and xylitol are used in sugar-free chewing gum.
Because of these attributes, the FDA recognizes mannitol and other sugar alcohols as beneficial to oral health.



BLOOD SUGAR:
Like other sugar alcohols (with the exception of erythritol), mannitol contains calories in the form of carbohydrate.
Mannitol is slowly and incompletely absorbed from our small intestine.
The remaining mannitol continues to the large intestine, where its metabolism yields fewer calories.
Because of this, mannitol consumption (compared with an equal amount of sugar) reduces insulin secretion, which helps keep blood glucose levels lower as a result.



PHYSICAL and CHEMICAL PROPERTIES of MANNITOL:
Molar mass: 182.172 g·mol−1
Molecular Weight: 182.17
XLogP3: -3.1
Hydrogen Bond Donor Count: 6
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 5
Exact Mass: 182.07903816
Monoisotopic Mass: 182.07903816
Topological Polar Surface Area: 121 Ų
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 105
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Appearance Form: powder
Color: white
Odor: No data available
Odor Threshold: No data available
pH: 5,0 - 6,5 at 182 g/l at 25 °C
Melting point/freezing point:
Melting point/range: 167 - 170 °C
Initial boiling point and boiling range: 290 - 295 °C at 4,67 hPa
Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available
Relative density: No data available
Water solubility: 182 g/l at 20 °C - completely soluble
Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Appearance: White crystalline powder
Assay (%): 98.0-102.0
Loss on drying (%): ≤0.5
Specific rotation: +23~+25°
Heavy metal (Pb) (%): <10ppm
Arsenic (%): ≤0.0002
Nickel (%): ≤ 0.30
Oxalate (%): <0.02
Sulfate (SO4) (%): ≤0.01
Chloride (Cl) (%): ≤0.003
Melting point ( ℃): 166-170 °C
Acidity: Conform
Residue on ignition: (%) <0.1
Storage in the shade

Synonyms: D-mannitol; Mannite; Osmitrol
IUPAC Name: (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Molecular Weight: 182.17
Molecular Formula: C6H14O6
Canonical SMILES: C(C(C(C(C(CO)O)O)O)O)O
InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChIKey: FBPFZTCFMRRESA-KVTDHHQDSA-N
Boiling Point: 295°C
Melting Point: 165-167°C
Flash Point: 100°C
Purity: 98%
Density: 1.52
Solubility: Soluble in DMSO (slightly), methanol (slightly), water.
Appearance: White Solid
Storage: Freezer
Assay: 0.99



FIRST AID MEASURES of MANNITOL:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of MANNITOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of MANNITOL:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MANNITOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains



HANDLING and STORAGE of MANNITOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of MANNITOL:
-Conditions to avoid:
no information available
-Incompatible materials:
No data available



SYNONYMS:
Aridol
Bronchitol
Cystosol
Osmitrol
Sag-M
D-mannitol
mannitol
69-65-8
Mannite
Osmitrol
Manna sugar
87-78-5
Cordycepic acid
Osmofundin
Resectisol
D-(-)-Mannitol
Mannit
Osmosal
Mannazucker
Mannidex
Mannigen
Mannistol
Diosmol
Invenex
Isotol
Mannitol, D-
Marine Crystal
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Maniton-S
Mannogem 2080
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
Bronchitol
Mannitol (VAN)
Aridol
Hexahydroxyhexane
DL-Mannitol
NCI-C50362
Mannitol (USP)
Mannitol [USP]
BRN 1721898
CHEBI:16899
MFCD00064287
3OWL53L36A
INS NO.421
133-43-7
E-421
mannitol-d
INS-421
Mannitol 5%
NSC-407017
Mannitol
1,2,3,4,5,6-Hexanehexol
Mannitol 10%
Mannitol 15%
Mannitol 20%
NCGC00164246-01
E421
Mannidex 16700
DSSTox_CID_3235
Osmitrol 5% In Water
DSSTox_RID_76936
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
DSSTox_GSID_23235
287100-73-6
MTL
MANNITOL 25%
Resectisol In Plastic Container
Mannitol 5% In Plastic Container
Mannitol 10% In Plastic Container
Mannitol 15% In Plastic Container
Mannitol 20% In Plastic Container
CAS-69-65-8
Osmitrol (TN)
SMR000857324
CCRIS 369
HSDB 714
SR-01000838849
NSC 9256
EINECS 200-711-8
EINECS 201-770-2
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
NSC 407017
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
UNII-3OWL53L36A
Cordycepate
Mannitolum
Manitol
D-mitobronitol
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
AI3-19511
Maniton s
Mannit p
D-Mannit
D-?Mannitol
Bronchitol (TN)
(D)-mannitol
Mannitol 25
Mannitol 35
Mannitol 60
D(-)Mannitol
Mannitol,(S)
Pearlitol 25 c
Pearlitol 50 c
Mannitol m300
Pearlitol 160 c
Mannitol 200
Mannitol 300
Pearlitol 200 sd
Pearlitol 300 dc
Mannitol 2080
D-Mannitol
D-Mannitol
MANNITOL
MANNITOL
MANNITOL
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
Crystalline mannitol fine
MANNITOL
D-[2-13C]Glucitol
MANNITOL
D-Mannitol, ACS reagent
D-Mannitol, >=98%
M0044
D-MANNITOL
MANNITOL
SCHEMBL919
bmse000099
CHEMBL689
Epitope ID:114705
Isomalt impurity, mannitol-
Crystalline mannitol standard
D-MANNITOL
4-01-00-02841
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
MLS001335977
MLS001335978
D-Mannitol, Biochemical grade
Crystalline mannitol extra-fine
D-Mannitol, AR, >=99%
D-Mannitol, LR, >=99%
DTXSID1023235
DTXSID30858955
MANNITOLUM
HMS2230N11
AMY33410
HY-N0378
ZINC2041302
Tox21_112092
Tox21_201487
Tox21_300483
POTASSIUMNONAFLUORO-T-BUTOXIDE
AKOS006280947
D-Mannitol, plant cell culture tested
Tox21_112092_1
BCP9000575
CCG-266445
D-Mannit 1000 microg/mL in Methanol
D-Mannitol, BioXtra, >=98% (GC)
DB00742
D-Mannitol, NIST(R) SRM(R) 920
ISOMALT IMPURITY B
NCGC00164246-03
NCGC00164246-04
NCGC00164246-05
NCGC00254277-01
NCGC00259038-01
85085-15-0
AC-12776
AC-14054
AS-30501
D-Mannitol, tested according to Ph.Eur.
D-Mannitol, p.a., 96.0-101.5%
D-Mannitol, SAJ first grade, >=99.0%
SORBITOL-MANNITOL COMPONENT MANNITOL
B2090
D-Mannitol, SAJ special grade, >=99.0%
E 421
S2381
SW220287-1
MANNITOL COMPONENT OF SORBITOL-MANNITOL
C00392
D00062
EN300-212188
AB00443917_06
065M361
ISOMALT IMPURITY, MANNITOL
Q407646
WURCS=2.0/1,1,0/[h1122h]/1/
Q-101039
SR-01000838849-3
SR-01000838849-4
D-Mannitol, ACS reagent, for microbiology, >=99.0%
LACTITOL MONOHYDRATE IMPURITY C [EP IMPURITY]
D-Mannitol, meets EP, FCC, USP testing specifications
Mannitol, European Pharmacopoeia (EP) Reference Standard
Z1198149813
D-Mannitol, BioUltra, >=99.0% (sum of enantiomers, HPLC)
Mannitol, United States Pharmacopeia (USP) Reference Standard
D-Mannitol, >=99.9999% (metals basis), for boron determination
Mannitol, Pharmaceutical Secondary Standard; Certified Reference Material
Mannitol, D-
Cordycepic acid
D-(-)-Mannitol
Diosmol
Isotol
Manicol
Maniton-S
Manna sugar
Mannidex
Mannigen
Mannistol
Mannit
Mannite
Osmitrol
Osmosal
Mannazucker
NCI-C50362
Resectisol
1,2,3,4,5,6-Hexanehexol
Mannitol
Mannogem 2080
Marine Crystal
Partek M
Pearlitol 25C
Osmitrol
87-78-5
Manna Candy
Cordycepic Acid
Sea Crystal
Maniton-S
Osmofundin

MAP (MONO AMONNIUM PHOSPHATE)
SYNONYMS Dodecyl sodium sulfate; SLS;Sulfuric Acid Monododecyl Ester Sodium Salt; Sodium Dodecanesulfate; Dodecyl Alcohol,Hydrogen Sulfate,Sodium Salt; Akyposal SDS; CAS NO:151-21-3
MARIGOLD HYDROGLYCERINED EXTRACT
Synonyms: Calendula officinalis, ext.;CALENDULA OFFICINALIS FLOWER EXTRACT;Calendulaofficinalisextract;MARIGOLDEXTRACT(CALENDULA;ENGLISHMARIGOLD;CALENDULAOFFICINALISFLOWEREXTRACTS;calendula officinalis linn., extract;phyteleneofmarigold CAS: 84776-23-8
MASESTER GMS 40
MASESTER GMS 40 is a versatile ingredient embraced for its roles as a conditioning agent, emollient, emulsifying agent, emulsion stabilizer, and skin conditioning agent across various applications.
Experience key benefits, including consistency and formula stability.
MASESTER GMS 402s versatility shines in beauty and care, skin care, and sun care.

CAS: 22610-63-5
MF: C21H42O4
MW: 358.56
EINECS: 245-121-1

MASESTER GMS 40 is a 1-monoglyceride that has stearoyl as the acyl group.
MASESTER GMS 40 has a role as an algal metabolite and a Caenorhabditis elegans metabolite.
MASESTER GMS 40 is a natural wax that is derived from the fats and oils of plants, animals, and insects.
MASESTER GMS 40 is a white, waxy, solid substance that is composed of long-chain fatty acids.
MASESTER GMS 40 is a widely used chemical in many industries, including the food, cosmetics, and pharmaceutical industries.
MASESTER GMS 40 is also used in the manufacture of candles and soaps.
MASESTER GMS 40 is an important chemical for its many beneficial properties, including its ability to act as an emulsifier, a lubricant, and a preservative.

MASESTER GMS 40 Chemical Properties
Melting point: 78-81 °C
Boiling point: 410.96°C (rough estimate)
Density: 0.9841
refractive index: 1.4400 (estimate)
storage temp.: −20°C
Yellow, waxy solid. Soluble in alcohol, hot ether, and acetone; insoluble in water. Combustible.

Synthesis Method
MASESTER GMS 40 is typically produced by the hydrogenation of vegetable oils, such as soybean oil, cottonseed oil, and palm oil.
This process involves adding hydrogen to the oil molecules in order to form a solid wax.
This process is known as hydrogenation and is typically done in the presence of a catalyst, such as nickel.
MASESTER GMS 40 is a white, waxy solid that is composed of long-chain fatty acids.

Uses
Stearin is used in a variety of scientific research applications, including biochemistry, pharmacology, and toxicology.
In biochemistry, stearin is used to study the structure and function of proteins and lipids.
In pharmacology, MASESTER GMS 40 is used to study the action of drugs on the body.
In toxicology, MASESTER GMS 40 is used to study the effects of toxins on the body.

Biochemical and Physiological Effects
MASESTER GMS 40 has a variety of biochemical and physiological effects on the body.
MASESTER GMS 40 can act as an emulsifier, which means that it can help to mix two substances that would otherwise not mix together.
MASESTER GMS 40 can also act as a lubricant, which means that it can help to reduce the friction between two surfaces.
Additionally, MASESTER GMS 40 can act as a preservative, which means that it can help to prevent the growth of bacteria and other microorganisms.

Synonyms
Glyceryl monostearate
123-94-4
Monostearin
GLYCEROL MONOSTEARATE
31566-31-1
Glyceryl stearate
Tegin
1-Stearoyl-rac-glycerol
1-MONOSTEARIN
Glycerin 1-monostearate
Stearin, 1-mono-
Stearic acid 1-monoglyceride
2,3-dihydroxypropyl octadecanoate
Glycerol 1-monostearate
1-Glyceryl stearate
Glycerin 1-stearate
Sandin EU
1-Monostearoylglycerol
Octadecanoic acid, 2,3-dihydroxypropyl ester
Aldo MSD
Aldo MSLG
Glyceryl 1-monostearate
Stearoylglycerol
Glycerol 1-stearate
alpha-Monostearin
Tegin 55G
Emerest 2407
Aldo 33
Aldo 75
Glycerin monostearate
Arlacel 165
3-Stearoyloxy-1,2-propanediol
Cerasynt SD
Stearin, mono-
2,3-Dihydroxypropyl stearate
.alpha.-Monostearin
Monoglyceryl stearate
Glycerol alpha-monostearate
Cefatin
Dermagine
Monelgin
Sedetine
Admul
Orbon
Citomulgan M
Drewmulse V
Cerasynt S
Drewmulse TP
Tegin 515
Cerasynt SE
Cerasynt WM
Cyclochem GMS
Drumulse AA
Protachem GMS
Witconol MS
Witconol MST
FEMA No. 2527
Glyceryl stearates
Monostearate (glyceride)
Unimate GMS
Glyceryl monooctadecanoate
Ogeen M
Emcol CA
Emcol MSK
Hodag GMS
Ogeen GRB
Ogeen MAV
Aldo MS
Aldo HMS
Armostat 801
Kessco 40
Stearic monoglyceride
Abracol S.L.G.
Arlacel 161
Arlacel 169
Imwitor 191
Imwitor 900K
NSC 3875
11099-07-3
Atmul 67
Atmul 84
Starfol GMS 450
Starfol GMS 600
Starfol GMS 900
Cerasynt 1000-D
Emerest 2401
Aldo-28
Aldo-72
Atmos 150
Atmul 124
Estol 603
Ogeen 515
Tegin 503
Grocor 5500
Grocor 6000
Glycerol stearate, pure
Stearic acid alpha-monoglyceride
Cremophor gmsk
Glyceryl 1-octadecanoate
Cerasynt-sd
Lonzest gms
Cutina gms
Lipo GMS 410
Lipo GMS 450
Lipo GMS 600
glycerol stearate
1-MONOSTEAROYL-rac-GLYCEROL
Nikkol mgs-a
Glyceryl monopalmitostearate
USAF KE-7
1-octadecanoyl-rac-glycerol
EMUL P.7
EINECS 204-664-4
EINECS 245-121-1
UNII-230OU9XXE4
Stearic acid, monoester with glycerol
Glycerol .alpha.-monostearate
Glyceroli monostearas
Glycerol monostearate, purified
Imwitor 491
Matricaria Extract
Synonyms: Matricaria recutita, ext.;CHAMOMILLA RECUTITA (MATRICARIA) EXTRACT;CHRYSANTCHRYSANTHELLUM INDICUM EXTRACTHELLUM INDICUM EXTRACT;CHAMOMILLA RECUTITA (MATRICARIA) LEAF EXTRACT;Matricariarecutitaextract;CHAMOMILLA RECUTITA (MATRICARIA) FLOWER EXTRACT;KAMILLEN-AUSZUG;Matricaria recutita, Extrakt CAS: 84082-60-0
Matricaria oily Extract
kamillenoel;CAMOMILE OIL;OIL, CAMOMILE;Matricaria Oil;Oils,chamomile;CHAMOMILE, MOROC;bluechamomileoil;OLEUMMATRICARIAE;camomileoilgerman;CHAMOMILE FLOWERS cas :8002-66-2
Matricaria recutita
matricaria chamomilla extract; chamomile extract hungarian; chamomile (blue) extract natural; chamomile extract hungarian; chamomile extract, apigenin 1.2%, 98%; matricaria recutita extract CAS NO:84082-60-0
MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE)
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a non-greasy, natural emollient that provides a silky skin feel.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is triglycerides with two or three fatty acids having an aliphatic tail of 6–12 carbon atoms, i.e. medium-chain fatty acids (MCFAs).


CAS Number: 65381-09-1 [Caprylic/ Capric triglycerides];
73398-61-5 [mixed glycerides – decanoyl and octanoyl]
EC Number: 265-724-3 (Caprylic/ Capric triglycerides);
277-452-2 (mixed glycerides – decanoyl and octanoyl)
CHEMICAL NAME: Octanoic/Decanoic Acid Triglyceride


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is fast drying and is an excellent wetting agent and binder in color cosmetics.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) also serves as a dispersing agent for inorganic UV filters and helps to form an occlusive barrier in skin and sun care formulations.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is highly versatile and suitable for all skin types and a wide variety of products.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) also known as Caprylic/Capric Triglycerides, Fractionated Coconut Oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is derived from the distilled fatty acid fractions of Palm Kernel Oil.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) esterified with USP high purity glycerin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is refined, Bleached and Deodorized.
Due to the large number of short chain fatty acids (C8 and C10s), MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is liquid at low temperatures.


Generally made from combining coconut oil and glycerine, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a soothing ingredient rich in fatty acids that works to neutralise toxins in the skin caused by environmental damage.
Utilized for MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s binding and preservative qualities in cosmetic products, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) promotes the skins’ healing abilities whilst locking in moisture and adding a light sheen.


Despite the word oil in its name, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is actually an ester, not a true oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) primarily contains Caprylic Acid and Capric Acid, medium chain triglycerides that are fluid at room temperature.


Medium-chain triglycerides (MCTs) are triglycerides made up of a glycerol backbone and three fatty acids with an aliphatic tail of six to 12 carbon atoms.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are found in natural foods, such as coconut oil, palm kernel oil, and raw coconut meat.
In the body, MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are broken down into glycerol and free fatty acids, which are directly absorbed into the blood stream and transported to the target organs to exert a range of biological and metabolic effects.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), in combination with other compounds like fish oils, soya oil, and olive oil, is indicated in adult and pediatric patients, including term and preterm neonates, as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are used in parenteral nutrition therapy: they serve as a source of calories and essential fatty acids in conditions associated with malnutrition and malabsorption.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are also available as over-the-counter natural products and health supplements.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a blend of isolated caprylic and capric triglycerides.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is usually isolated from coconut oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) functions as a carrier oil in our products.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is triglycerides with two or three fatty acids having an aliphatic tail of 6–12 carbon atoms, i.e. medium-chain fatty acids (MCFAs).
Rich food sources for commercial extraction of MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) include palm kernel oil and coconut oil.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a commonly used component in soaps and also cosmetics.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)’s normally made with a mix of coconut oil as well as glycerin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is sometimes called capric triglyceride and also is often inaccurately called fractionated coconut oil.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), alternatively known as Octanoic/Decanoic Acid Triglyceride or MCT Coconut Oil, is a specialized esterification of coconut oil extracted from the kernel of matured coconuts.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is obtained from fractionation of a lauric-type oil.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) obtained has a melting point of about 7 ° C.
When in liquid form, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is almost colourless and with a characteristic odour.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also known as MCT (medium chain triglyceride).


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has an almost equal composition of caprylic and capric acids.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a natural product derived from vegetables (coconut or palm kernels).
Is a natural neutral oil, also called MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a mixture of medium-chain fatty acids (triglycerides) of natural origin.
Neutral oil, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), is non-irritant, easy to apply and is quickly absorbed.
As a component of cosmetic products, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) improves their application properties and prevents excessive lipid replenishment.


As such, any imbalance present in irritated and overprotected skin can quickly be restored.
Cosmetic properties of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): absolutely non-irritant, ideal for irritated skineasy to apply & rapidly absorbedpromotes the application properties of other ingredientsprevents excessive lipid replenishment.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), or capric triglyceride, is a compound that combines fatty acids from natural oils, such as coconut oil, with glycerin.
Soaps and cosmetics sometimes include MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) as an ingredient.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a compound that comes from combining fatty acids with glycerin.
The fatty acids in MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) are medium-chain triglycerides (MCTs).
The Cosmetic Ingredient Review (CIR) note that these fatty acids come from rich oils, such as coconut or palm oil.


Manufacturers remove and isolate fatty acids from the oil as caprylic acid.
They combine these pure fatty acids with glycerin to make MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) – also known as MCT Oil – is a classic emollient derived from renewable natural raw materials.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is produced from vegetable Glycerine and fractionated vegetable Fatty Acids, mainly Caprylic and Capric Acids.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a clear and colourless liquid, neutral in odour and taste.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is fully saturated and therefore highly resistant to oxidation.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is triglyceride derived from glycerol and 3 medium chain fatty acids (C8 – C10).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a liquid oil manufactured through the esterification of glycerol using medium-chain fatty acids isolated from natural sources (Coconut Oil, Palm Oil, or a combination of the two).


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a lightweight and nourishing oil that exhibits unique sensory and chemical characteristics.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is colorless (or a very pale yellow in color) with a mild characteristic odor and remains in a liquid state at room temperature, making it highly convenient to use.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) also shows high resistance to oxidation.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a type of oil synthesized from pure Coconut Oil (and sometimes Palm Oil).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is composed predominantly of Medium Chain Triglycerides (MCTs).


This causes MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) to display special qualities and properties including high stability, lightweight texture, fast absorption, colorless or very pale-colored appearance, and an extremely light odor while retaining the skin-replenishing and moisturizing benefits of the source fatty acids.


The term 'triglyceride' refers to a type of lipid that is made up of the elements carbon (C), hydrogen (H), and oxygen (O).
These elements are arranged in the form of a glycerol unit (the structural 'backbone' of the triglyceride compound), alongside three chains of fatty acids attached to it.


Due to the varying chemical composition of fatty acids, they come in different sizes and can be classified according to the number of carbon atoms they have.
Short-chain fatty acids have less than 6 carbon atoms, medium-chain fatty acids have 6-12 carbon atoms, while long-chain fatty acids have 13-21 carbon atoms.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are naturally-occurring triglyceride compounds that consist of a glycerol component with fatty acid chains that are medium-sized in length; in other words, they are composed of medium-chain fatty acids.


These could be any one of the following:
C6 (having 6 Carbon atoms) - Caproic Acid
C8 (having 8 Carbon atoms) - Caprylic Acid
C10 (having 10 Carbon atoms) - Capric Acid
C12 (having 12 Carbon atoms) - Lauric Acid


MCTs can be found in vegetable oils and animal dairy products such as milk, butter, clarified butter, and cheese.
Coconut Oil and Palm Oil are both rich sources of MCTs, and MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is therefore made from these natural oils.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), also known as Caprylic Capric Triglycerides, is gaining widespread attention within the beauty, cosmetic and personal care industries due to its impressive silky, oil-free texture and oxidative stability.
Despite the word oil in its name, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is actually an ester, not a true oil.


It primarily contains Caprylic Acid and Capric Acid, medium chain triglycerides that are fluid at room temperature.
Not all commercially available MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are produced solely from coconuts.
Some MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) products may be produced using unsustainable rapeseed and/or palm oils.


To produce MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), a process called esterification is used.
Coconut oil is first hydrolyzed to yield the medium chain fatty acids and glycerol.
The glycerol is reserved, and the fatty acids undergo distillation to separate them into fractions of different chain lengths.


The C8 Caprylic Acid and C10 Capric Acid fractions are then re-esterified with glycerol to form MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is then filtered and deodorized.


Unlike pure Virgin Coconut Oil that has a characteristic coconut aroma and that is solid and opaque at room temperature, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a clear, colorless and virtually odorless fluid that pours easily at room temperature.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a fraction of the coconut oil from which almost all the long chain triglycerides are removed, thus leaving mainly the medium-chain triglycerides and making it an absolutely saturated oil.


This saturation gives MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) great stability and resistance to oxidation, in fact, that it has an almost indefinite shelf life.
In addition, fractionating raises the comparative concentration of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), thus giving it more of antioxidant and disinfecting effect, hence the INCI Name: MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), also known as Caprylic Capric Triglycerides (CCTG), is gaining widespread attention within the beauty, cosmetic and personal care industries due to its impressive silky, oil-free texture and oxidative stability.
Despite the word oil in its name, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is actually an ester, not a true oil.


Uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): All kinds of personal care products (e.g. soaps, face/ body oils, creams, lotions, cleansers, shampoos, shower gels, conditioners, bath bombs, bath salts).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is added to the formula to the oil phase.


The typical use level of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is 1-100%.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is used for external use only.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is both similar to and different from fractionated coconut oil.


While fractionated coconut oil takes whole coconut oil and seperates out the light-weight, liquid triglycerides (C8-C10), MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is made by starting with Glycerin then building C8 and C10 triglycerides in an ordered and controlled way.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is soluble in mineral oil, vegetable oil and alcohol.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is insoluble in water.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), is a liquid form of oil, obtained by separating Capric and Caprylic fatty acids (Medium Chain Triglycerides) from hard oil.


Unlike hard oils, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) stays liquid at room temperature.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has a smooth, silky feeling, and is easily absorbed into the skin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) gives products a lighter, more luxurious finish.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is fats found in foods like coconut oil.
They’re metabolized differently than the long-chain triglycerides (LCT) found in most other foods.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a supplement that contains a lot of these fats and is claimed to have many health benefits.


Triglyceride is simply the technical term for fat.
Triglycerides have two main purposes.
They’re either burned for energy or stored as body fat.


Triglycerides are named after their chemical structure, specifically the length of their fatty acid chains.
All triglycerides consist of a glycerol molecule and three fatty acids.
The majority of fat in your diet is made up of long-chain fatty acids, which contain 13–21 carbons.
Short-chain fatty acids have fewer than 6 carbon atoms.


In contrast, MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) have 6–12 carbon atoms.
The following are the main MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride):
*C6: caproic acid or hexanoic acid
*C8: caprylic acid or octanoic acid
*C10: capric acid or decanoic acid
*C12: lauric acid or dodecanoic acid


Some experts argue that C6, C8, and C10, which are referred to as the “capra fatty acids,” reflect the definition of MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) more accurately than C12 (lauric acid).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an oily compound that can prevent ingredients from clumping together.


Due to this property, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) could improve the texture of products that contain the compound.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a dispersing agent stabilizes and binds ingredients in a product.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) may help evenly distribute product ingredients, such as solid pigments, scents, or other compounds.


This even distribution can create a more consistent texture and stable blend.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are fats that are naturally found in coconut oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)’s are more easily and rapidly digested than other types of fats and provide energy, support the metabolism and are burned by the body for energy and fuel.


In conjunction with a balanced diet and exercise, consuming MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can support weight management.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), more commonly referred to as MCTs, have made quite a splash in the nutrition world, and with good reason—they are pretty amazing fats.


To understand what a medium chain triglyceride is, it is helpful to first understand the chemical structure of fats.
The fats we find in nature are generally triglycerides, which consist of three fatty acids attached to a glycerol backbone.
The fatty acids themselves are chains of carbon atoms varying in length from 4 carbons to 26 or more, commonly classified as short, medium and long chain.

In nature the fatty acids that make up a triglyceride are usually a combination of different length fatty acids and not three of the same length.
So a naturally occurring triglyceride is some combination of short, medium and long chain fatty acids.
When we talk about the benefits of MCTs, we are mostly talking about the benefits of the individual medium chain fatty acid tails, or MCFAs, defined as fatty acids that are 6-12 carbons long.


These fatty acids are caprioc acid (6 carbons), caprylic acid (8 carbons), capric acid (10 carbons) and lauric acid (12 carbons).
There is some debate whether lauric acid is a true medium chain fatty acid, but we’ll cover that more in a minute.
MCFAs are unique because they are digested by the body differently than other length fatty acids (such as the omega-3 and -6 fatty acids and oleic acid from olive oil).


Their shorter structure makes them easier to break down in the intestines and they require little to no bile.
Once absorbed, MCFAs are transported directly to the liver, where they are preferentially metabolized to create energy.
MCFAs can also easily enter the cells where they fuel energy production.


Because medium-chain fatty acids are so easily used for energy, they are not readily stored as fat.
While MCFAs are found in many foods, including coconut oil, palm oil, butter, and full-fat dairy (and in particular goat dairy), the amounts available from these foods tend to be pretty low.


So to concentrate the beneficial MCFAs, manufacturers use a process called fractionation to separate the fatty acids from the glycerol backbone and then recombine them into triglycerides that are comprised only of MCFAs.
These are the MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) you’ll find on our shelves.


Generally the original sources of the MCFAs are coconut and/or palm oils.
Caprylic and capric acid are usually the main MCFAs found in MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), and their proportions vary from manufacturer to manufacturer.


Caproic acid is usually left out because it has a strong taste and can cause a burning sensation in the throat and stomach.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a mixed ester composed of caprylic and capric fatty acids attached to a glycerin backbone.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are sometimes erroneously referred to as fractionated coconut oil, which is similar in composition but typically refers to coconut oil that has had its longer chain triglycerides removed.
Chemically speaking, fats and oils are made up mostly of triglycerides whose fatty acids are chains ranging from 6–12 carbon atoms, in this case the ester is comprised of capric (10 carbon atoms) and caprylic (8 carbon atoms).


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are a specialized esterification of Coconut Oil using just the Caprylic and Capric Fatty Acids, while Fractionated Coconut Oil is a standard, distillation of Coconut Oil which results in a combination of all of the fatty acids, pulled through the distillation process.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is non-greasy and light weight.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) comes in the form of an oily liquid and mainly works as an emollient, dispersing agent and solvent.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are partially man-made fats.
The name of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) refers to the way the carbon atoms are arranged in their chemical structure.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are generally made by processing coconut and palm kernel oils in the laboratory.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are fats that are naturally found in coconut and palm kernel oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s are more easily and rapidly digested than other types of fats, as they require lower amounts of enzymes and bile acids for intestinal absorption.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s are metabolized very quickly in the liver and are reported to encourage an increase in energy expenditure, while decreasing fat storage. Numerous studies suggest that substituting MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) for other fats in a healthy diet may therefore help to support healthy weight and body composition.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a clear that is highly stable and resistant to oxidation for use in creams, lotions, and many other cosmetic preparations for skin and hair.
Because it is chemically indifferent to other cosmetic ingredients, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) acts as a viscosity regulator and assists in the dispersion of pigments and other additives.


Further, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) penetrates the skin readily, thus acting as a carrier for transdermal therapeutic ingredients.
This ability to transport Essential Oils and actives makes MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) an oil of choice among medical practitioners and massage therapists.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are a specific fraction of coconut / palm oil fatty acids resulting in only the more stable, and skin loving oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also known as MCT OIL.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is massage oil, perfume carrier, general carrier oil, light weight, and moisturizer for all skin types.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also known as Fractionated Coconut Oil.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are fats that are naturally found in coconut and palm kernel oils.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride), including caprylic acid and capric acid.
With normal use, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) oil is not converted to body fat.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is made of naturally occurring fatty acids found in coconut oil and glycerine.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s smooth texture and super moisturizing properties make it extremely useful in making soaps and myriads of cosmetic products.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is valued as a natural alternative to synthetic chemicals found in topical skin products.
Companies which claim that their products are “all natural” or “organic” usually contain CCTG (also known as MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)).


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) creates a barrier on the skin’s surface, which helps reduce skin dryness by reducing loss of moisture.
The oily texture helps to thicken and provides a slipperiness, which helps make lotions and natural strength deodorants easy to apply and leaves a non-greasy after-touch.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) functions as an emollient, dispersing agent, carrier or base, & also has anti-oxidant properties.



USES and APPLICATIONS of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Due to their ability to be absorbed rapidly by the body, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has found use in the treatment of a variety of malabsorption ailments.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) supplementation with a low-fat diet has been described as the cornerstone of treatment for Waldmann disease.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an ingredient in some specialised parenteral nutritional emulsions in some countries.
Studies have also shown promising results for epilepsy through the use of ketogenic dieting.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is highly versatile and is suitable for all skin types.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is gentle enough for sensitive skin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is especially attractive for incorporation into oil-free cosmetic and personal care formulations intended for oily, combination or problem skin types.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also an exceptional substitute for mineral oil. Within aromatherapy and fragrancing applications, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) serves as a virtually odorless carrier for essential oils and other aromatics.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) absorbs rapidly and possesses a highly desirable, silky, powdery feel. MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can be incorporated into massage formulations or used on its own as a very light, non-greasy massage oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is especially attractive for incorporation into oil-free cosmetic and personal care formulations intended for oily, combination or problem skin types.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) absorbs rapidly and possesses a highly desirable, silky, powdery feel.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can be incorporated into massage formulations or used on its own as a very light, non-greasy massage oil.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also an exceptional substitute for mineral oil.
Within aromatherapy and fragrancing applications, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) serves as a virtually
odorless carrier for essential oils and other aromatics.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), also known as Caprylic Capric Triglycerides, is gaining widespread attention within the beauty, cosmetic, and personal care industries due to its impressive silky, oil-free texture and oxidative stability.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is highly versatile and is suitable for all skin types.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is gentle enough for sensitive skin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is considered Sustainable, Vegan, Lactose Free, Gluten Free, Glutamate Free, BSE Free, No Hydrogenated or Partially Hydrogenated Oils, No Preservatives.


Derived from coconut oil (and commonly used in cosmetic products to help bind ingredients together), MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) creates a breathable layer on the skin, locking moisture in.
Common Uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Creams, Lotions, Soaps, and Moisturisers


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) stands for Medium Chain Triglycerides and is also commonly known by its INCI name Capric Caprylic Triglyceride (CCT).
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can be derived from Palm or Coconut oil (when it is usually referred to as Fractionated Coconut Oil).


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is widely used in cosmetics as a dispersing agent but also functions as a solvent for fat-soluble vitamins and other active nutrients.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an excellent emollient and rapidly penetrates the skin.


Once MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has penetrated it slows the loss of water from the skin by forming a barrier on the skin’s surface.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also used to alter the thickness of liquid products, improving the spread and providing a silky and even application that promotes dispersion of other ingredients in finished products.


This provides and maintains a beautifully smooth and lustrous after-touch when applied to the skin.
Cosmetic manufacturers highly value MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) as well for it possesses great stability and resistance to oxidation, hence its long natural shelf life.


Skin: Emollient: MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) improves skin feel of formulations.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is intended for external use only.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is found in topical skin care items, including facial moisturizers, anti-aging lotions, sun blocks, eye creams, and so on.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can expand the service life of cosmetics, make your skin better and also not oily, and enhance the antioxidant impact in items.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also a common component in cosmetics as well as other aesthetic items.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) uniformly distributes ingredients in aesthetic solutions without leaving your skin feeling greasy.
You’ll see MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) frequently in the adhering to cosmetic products: lipstick, lip balm, lip lining, primer, structure.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has been made used for over 50 years.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)
has a smoothing result on the skin as well as great anti-oxidant activity.


Additionally, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has the result of binding various other components with each other and serves as a chemical, assisting the energetic components in cosmetics to last much longer.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is considered a natural option to various other synthetic chemicals located in topical products.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is used mines, esters, fatty alcohols, peroxides, fragrances, flavors, surface finishing, lubricants, metal soaps, cosmetics, animal feed, chemical, paper, plastics, detergents, chemicals, resins and coatings.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is commonly used as an emollient and enhancer for the performance of cosmetic actives, additives and other cosmetic products.


Also, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is beneficial in preventing moisture loss in formulations.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) applications span across a variety of industries.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is silky and light to the touch, absorbing into the skin easily.


This means when MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)’s used in cosmetic and skincare products, organic MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) oil leaves no greasy feeling on the skin.
With a long shelf life, low color, minimal odor and low to no hazard, this carrier oil is an ideal selection for sensitive skin and oil free products.


This oil uses only the MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride), namely Caprylic Acid and Capric Fatty Acid, contained in raw coconut oil.
The result is an ideal carrier oil that can be used in a variety of applications.


Acme-Hardesty provides quality MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), produced using ethically sourced supplies.
Aerosols uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Antiperspirants, Deodorants, Perfumes
Hair Care uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Oils, Masks


Skin Care uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Facial Creams & Masks, Body Lotions & Oils, Nail Care, and Hand & Foot Care
Oils uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Massage, Bath & Shower, and Shaving


Sun Care uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Sunscreens, After Sun, and Self-Tanning
Colour Cosmetics uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Eyeshadow, Blush Powder, Primers, Lipsticks, and Make-up-remover
Lip Care uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Balms, Creams, and Sticks


Baby Care uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Creams, Lotions, Cleansing, and Wet Wipes
Men’ Grooming uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Shaving Creams & Oils, After Shave Oils & Lotions, and Beard Oils & Balms.
Usual dietary fats, by comparison, are long-chain triglycerides.


People use MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) as medicine.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are used along with usual medications for treating food absorption disorders including diarrhea, steatorrhea (fat indigestion), celiac disease, liver disease, and digestion problems due to partial surgical removal of the stomach (gastrectomy) or the intestine (short bowel syndrome).


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are also used for “milky urine” (chyluria) and a rare lung condition called chylothorax.
Other uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) include treatment of gallbladder disease, AIDS, cystic fibrosis, Alzheimer's disease, and seizures in children.


Athletes sometimes use MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) for nutritional support during training, as well as for decreasing body fat and increasing lean muscle mass.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are sometimes used as a source of fat in total parenteral nutrition (TPN).
In TPN, all food is delivered intravenously (by IV).


This type of feeding is necessary in people whose gastrointestinal (GI) tract is no longer working.
Intravenous MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are also given to prevent muscle breakdown in critically ill patients.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is popular in aromatherapy and massage therapy as a carrier oil as it does not interfere with the scent of aromatic blends, absorbs rapidly, does not stain clothing, and leaves behind a silky but non-greasy feeling to the skin.


In cosmetic formulations, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is ideal in emulsions or when a soothing and non-greasy emollient is required with neutral sensory characteristics and a long shelf life.
Apart from aromatherapy and cosmetics, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is widely featured in the food industry as well as in nutritional, pharmaceutical, weight loss, and other health applications.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) in general are employed extensively across a wide range of sectors, including cosmetics, personal care, aromatherapy, nutrition, pharmaceuticals, and medicine.
Applications of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride): Skin Care, Lip Care, Hair Care, Nail Care, Cosmetics, Aromatherapy, and Massage


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is considered to be an excellent emollient and skin-repairing ingredient.
As an emollient, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) both quickly penetrates the surface to condition the skin/hair, and provides a lightweight and non-greasy barrier of lubrication.


As a dispersing agent, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) helps enhance the delivery of vitamins, pigments and other active ingredients contained in a solution so that they become evenly spread out and fully absorbed by the epidermis.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s oily texture helps thicken cosmetic formulations and is slippery which in turn allows for the easy spreadability of solutions and a smooth after-touch.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)’s included in cosmetics due to its mix of fatty acids that skin can use to repair its surface and resist moisture loss.
Also MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is thought to have an anti-inflammatory effect on the skin.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is used to enhanse the performance of flavour, fragrance and/or colour additives helping boost their solubility and efficacy through a formula.
In addition MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) provides emollience to formulations and can help enhanse the performance of skin care actives.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is used as a natural solvent in many formulations and can also help prevent moisture loss in a formulation.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can be used in all skin and hair formulations.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are medium-chain (6 to 12 carbons) fatty-acid esters of glycerol most frequently used in nutraceutical foods and beverages and cosmeceutical personal care products.
In the human body, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) passively diffuse from the GI tract into the portal vein without requirement for modification that long-chain fatty acids or very-long-chain fatty acids require.


Since MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are bland compared to other fats and do not generate flavor or fragrance off-notes, they are also used in personal care products and pharmaceuticals.
In foods, beverages and nutraceutical applications, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) ingredients rapidly absorb into the body and are a potentially good energy sources for everyday exercise enthusiasts as well as athletes and bodybuilders.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride)are often incorporated into beverages, mixes, nutritional bars or energy foods.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are also used as high quality carriers and emollients in the formulation of cosmetics to be certified according to the Natural and Organic Ecocert Standards.


MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are frequently found in topical aerosols, foams, creams, ointments and lotions, and are regularly used in flavorings and fragrances because of their bland taste profiles and low natural odor.
Organic MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) acts as an excellent emollient. Used in body-, face-, hair- and sun care.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is of vegetable origin and consists of a mixture of vegetable fatty acids, mainly caprylic and capric acid and glycerine.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is particularly kind to the skin and does not leave an oily shine.


MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is used Emollient, Hydrating Agent, Non-Greasy Oil Base.
Due to its remarkable versatility and appealing sensory characteristics, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is incorporated in a wide range of applications in the personal care, cosmetic, and aromatherapy sectors.


On its own, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) may be used as a cosmetic, massage, and carrier oil, or it can be incorporated in the manufacturing of creams, lotions, cleansing oils, salves, body butter, bath scrubs, makeup, and many other nourishing products.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is particularly popular amongst massage therapists as it is easy to use, lightweight, and dries quickly without being greasy.


Unlike other oils, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) also does not typically stain clothing. MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s reputed antimicrobial and anti-inflammatory effects further help improve the skin's complexion and facilitate massage therapy by improving the absorption of essential oils and other therapeutic constituents.


-Skin care:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a stable compound that has an oily texture.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can create a barrier on the skin’s surface to lock in moisture.
Several skin care products contain MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), such as:
*face creams
*body moisturizers
*sunscreens
*eye creams
*anti-aging serums
*Makeup


-MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also a stable alternative to other oils.
Cosmetics and makeup containing fatty compounds may use MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).
These products include:
*lip balm
*lip liner
*lipstick
*eyeliner
*liquid foundation or blush


-Foods:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) may also be present in preprepared foods, such as:
*baked goods
*soft candies
*cheeses
*frozen dairy products
*gelatins and puddings
*meat products


-Technical uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is bland compared to other fats and do not generate off-notes (dissonant tastes) as quickly as LCTs.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also more polar than LCTs.
Because of these attributes, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is widely used as carrier oils or solvents for flavours and oral medicines and vitamins.


-Pharma relevance:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can be used in solutions, liquid suspensions and lipid-based drug delivery systems for emulsions, self-emulsifying drug delivery systems, creams, ointments, gels and foams as well as suppositories.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are also suitable for use as solvent and liquid oily lubricant in soft gels.


-Medical relevance:
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) passively diffuse from the GI tract to the portal system (longer fatty acids are absorbed into the lymphatic system) without requirement for modification like long-chain fatty acids or very-long-chain fatty acids.
In addition, MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) do not require bile salts for digestion.

Patients who have malnutrition, malabsorption or particular fatty-acid metabolism disorders are treated with MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) because MCTs do not require energy for absorption, use, or storage.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are generally considered a good biologically inert source of energy that the human body finds reasonably easy to metabolize.

MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) have potentially beneficial attributes in protein metabolism but may be contraindicated in some situations due to a reported tendency to induce ketogenesis and metabolic acidosis.
However, there is other evidence demonstrating no risk of ketoacidosis or ketonemia with MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) at levels associated with normal consumption, and that the moderately elevated blood ketones can be an effective treatment for epilepsy.


-Calorie restriction:
A 2020 systematic review and meta-analysis by Critical Reviews in Food Science and Nutrition supported evidence that MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) decreases subsequent energy intake.
Despite this, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) does not appear to affect appetite, and thus the authors stated that further research is required to elucidate the mechanism by which this occurs.


-Dietary relevance:
Molecular weight analysis of milk from different species showed that while milk fats from all studied species were primarily composed of long-chain fatty acids (16 and 18 carbons long), approximately 10–20% of the fatty acids in milk from horses, cows, sheep, and goats were medium-chain fatty acids.
Some studies have shown that MCTs can help in the process of excess calorie burning, thus weight loss.

MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are also seen as promoting fat oxidation and reduced food intake.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) have been recommended by some endurance athletes and the bodybuilding community.
While health benefits from MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) seem to occur, a link to improved exercise performance is inconclusive.

A number of studies back the use of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) oil as a weight loss supplement, but these claims are not without conflict, as about an equal number found inconclusive results.


-Personal Care uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride):
Commonly used as an emollient, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) serves as a replacement for White Oils and Petrolatum in makeup, moisturizers, skin care and sunscreen products and perfumes.
Within this application, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) serves as an excellent choice for sensitive skin products due to its lightweight nature and compatibility with most skin types.


-Pet Food uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) coconut oil can be used as an ingredient in pet foods, and research does suggest the inclusion of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) oil has positive effects on feline metabolism and canine cognitive function.


-Pharmaceuticals:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an efficient solvent and excellent excipient, meaning it can act as a carrier or suspension medium for oil soluble antibiotics, drugs and vitamins.


-Food and Beverages uses of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is promoted as an energy supplement and digestive agent in the food industry.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)’s commonly used as a food emulsifier.


-Flavor and Fragrance:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an excellent carrier for both fragrances and flavors, as it’s a low-odor oil.


-Nutraceuticals:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is itself an energy supplement and digestive agent, promoting metabolism boosts.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)’s also an excellent emulsifier and solvent and can act as a carrier or suspension medium for oil-soluble vitamins and minerals.


-Pharmacodynamics:
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) contained in injectable lipid emulsions serve as a source of calories and essential fatty acids, which are important substrate for energy production.

MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) exert several metabolic effects: they were shown to reduce weight, metabolic syndrome, abdominal obesity, and inflammation in animal studies.
It is proposed that MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) induces weight loss through increasing energy expenditure and fat oxidation, and altering body composition.4

However, it is unknown whether the effects of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) on energy expenditure and body weight are long-lasting and sustainable.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can also play a role in food intake and satiety, as some studies showed that MCT consumption led to reduced food intake.

While MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) was shown to reduce energy intake, it was not shown to affect appetite.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)may facilitate the absorption of calcium.


-Applications of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride):
*All Skin Care Creams and Lotions - Both cleansers and moisturisers
especially for sensitive skin and oily skin
*Bath and Body Care Creams and Lotions: especially for sensitive skin and oily skin
*Bath and Body Oils
*Make Up: especially lipsticks and balms
*Natural Perfumes
*Shampoos and Cleansers



FUNCTIONS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) mainly works as an emollient, dispersing agent and solvent.
Cosmetic manufacturers highly value MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) for its lack of colour and odour, as well as for its stability.



BENEFITS AND USES OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
*This is the most effective skin-softening ingredient, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride), that is used worldwide.
*MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) creates a barrier on the skin's surface, which helps to reduce skin dryness by decreasing the loss of moisture. *MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s oily texture helps to thicken and provides a slipperiness, which helps make our lotions and natural strength deodorants easy to apply and leaves a non-greasy after-touch.

*MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a brilliant storehouse of antioxidants that will enrich your skin to make it healthy.
*MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is used to boost the shelf life of your products.
*MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) helps soften dead skin and repair cracked and broken skin.

*When used in eyeliners or kohls MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) makes them smooth and their application easy.
*Carrier for flavours, fragrance (including essential oils) or colours, light-weight emollient, high stability, crystal clear.



USES & EFFECTIVENESS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Possibly Effective for...
*Certain types of seizures in children.
*Preventing muscle breakdown in critically ill patients, when given intravenously (by IV).
*MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can provide calories in critically ill patients, but doesn't seem to offer any advantages over normal dietary fats (long chain triglycerides).

-Possibly Ineffective for...
Weight loss associated with AIDS.
Some research shows that taking MCTs does not seem to be any more effective than taking multivitamins and minerals alone for prevention of weight loss associated with AIDS.

Insufficient Evidence to Rate Effectiveness for...
*Alzheimer's disease.
There is interest in using MCT - Medium Chain TriglycerideS (Caprylic / Capric Triglyceride) to treat Alzheimer’s disease because MCTs might provide extra energy to the brain and might also protect the brain against damage from beta-amyloid protein plaques.

These plaques are the structures that form in Alzheimer’s disease and cause symptoms.
Some research shows that a specific MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) product (AC-1202) does not significantly improve learning, memory and information processing (cognitive thinking) in people with mild to moderate Alzheimer's disease, except in people with a particular genetic make-up (change in the APOE4 gene).

In the people with the APEO4 gene change, a single dose of the MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) product seems to improve cognitive thinking skills.

*Chylothorax (a rare lung disorder). Taking MCTs by mouth or intravenously (by IV) might prevent malnutrition and a weakened ability to fight infection in children and adults with chylothorax.
*Nutritional support of athletic training.

*Decreasing body fat and increasing lean muscle.
*Improving the absorption of calcium and magnesium.



PROPERTIES OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
• Palm-Free
• Oil-Free
• Highly Stable
• Light
• Clear, Colorless to Yellow
• Virtually Odorless
• Fluid at Room Temperature
• Rapid Absorption
• Non-Greasy
• Smooth, Silky Texture When Applied to Skin
• Minimal to No Sheen Upon Application
• Suitable for All Skin Types
• Emulsifi es Easily
• See Spec Sheet for Fatty Acid Composition



HOW MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) WORKS:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) helps bind moisture to the skin and prevents its loss from the skin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) works by enhancing dispersion in the formulations.



CONCENTRATION AND SOLUBILITY OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
The recommended concentration of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) for use is 2% to 100%.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is soluble in all proportions in acetone, benzene, chloroform, and insoluble in water.



HOW TO USE MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Heat MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) phase to 70o
Add MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)to the oil phase while constantly stirring it.
Add MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) phase to the water phase.
Stir until a homogenous solution is formed.



BENEFITS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
*An effective emollient that absorbs quickly
*Minimal to No Sheen Upon Application
*Emulsifies Easily
*Suitable for All Skin Types



FUNCTIONS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
*Dispersing agent
*Emollient Moisturiser
*Oil Substitute
*Solubiliser
*Solvent
*Spreading Agent
*Viscosity Modifier



BENEFITS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) originates from all-natural fats.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is clear liquids with a somewhat wonderful taste.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride)'s high fat web content, appearance, and also antioxidant capacity make them widely made use of in skin care items and also soaps.

-Emollients:
Moisturizers make your skin softer.
Moisturizers work by securing wetness in the skin and also creating a safety layer to make sure that wetness can not run away.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a commonly utilized emollient active ingredient in cosmetics.

-Dispersants maintain the active ingredients in a formulation with each other.
Mixing active ingredients, colorants or fragrances in a great dispersant keeps the ingredients from clumping or sinking to the bottom of the blend.

-Solvents:
A solvent is a component that dissolves or damages some other active ingredient or bond in a substance.
An ingredient is taken into consideration a solvent based upon its molecular structure and form as well as exactly how it interacts with other materials.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) liquifies the compounds, enabling them to mix together. While some solvents contain hazardous ingredients, caprylic triglyceride is relatively risk-free.

-Anti-oxidants:
Antioxidants are substances that counteract cost-free radicals or harmful materials that you are subjected to daily.
Antioxidants assist prevent oxidation, which ages your skin and problems your body.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is rich in antioxidants, so they play a vital duty in safeguarding your skin and aiding you really feel more youthful.



BENEFITS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Benefits of Fractionated Coconut Oil:
*Defends chapped and cracked lips from further damage
*Moisturises and cleanses skin with a light oil consistency
*Provides antioxidant based antibacterial support to the skin and face



PROPERTIES OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) MAKES IT SUITABLE FOR USE IN VARIOUS APPLICATIONS:
*Fast Spreading, light skin feel – personal care ingredient
*Oxidative stability, low viscosity, clean organoleptic quality – solvent for flavour, pharmaceautical, lubricant
*Lower caloric value, rapid available source of energy – health management



SOURCES OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) is found in palm kernel oil and coconut oil and can be separated by fractionation.
They can also be produced by interesterification.
Retail MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) powder is MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) oil embedded in starch and thus contains carbohydrates in addition to fats.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is manufactured by spray drying.



BENEFITS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is a compound of glycerin and naturally occurring fatty acids from coconut or palm oil.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) may have some benefits for the skin or the products that contain it.
*Emollient:
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an emollient is an ingredient that softens the skin.
Emollients form a protective layer on the skin, locking in moisture to prevent the skin from drying out.
The oily texture of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) makes it a useful skin softener.



BENEFITS & COMPOSITION OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Due to its uniquely customized chemical make-up, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) displays wide-ranging benefits that relate to its appealing sensory and physicochemical characteristics.

The main chemical constituents responsible for these characteristics are Caprylic Acid (C8) and Capric Acid (C10), which makes up roughly 60% and 40% of the oil, respectively.
These fatty acids also contribute to the nourishing cosmetic and health benefits observed with MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).

The beneficial physio-chemical properties of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) include:
*Colorless or very pale yellow in appearance
*Emits a mild characteristic odor
*Remains in a liquid state at room temperature
*Low viscosity and lightweight texture
*Absorbs rapidly into the skin
*Non-greasy and non-staining
*Excellent heat stability (can be heated or frozen)
*Excellent oxidative stability, contributing to the lifespan of products
*Acts as a versatile solvent, as it is soluble in lipids and oils, in addition to acids and alcohols


In addition to these characteristics, Caprylic Acid (C8) and Capric Acid (C10) fatty acids are believed to have extensive benefits for skincare and health:
*Reputed antibacterial, antiviral, and antifungal properties
*Powerful anti-inflammatory properties
*Powerful antioxidant properties
*Provides a fast-releasing source of energy
*Used as a natural treatment for acne and inflammatory skin conditions such as eczema
*Helps regulate cholesterol
*Helps with weight management



THE FOLLOWING SUMMARY HIGHLIGHTS THE THERAPEUTIC PROPERTIES AND ACTIVITIES THAT MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) IS BELIEVED TO SHOW:
*COSMETIC: Emollient (Soothing/Softening), Conditioning, Hydrating, Revitalizing, Strengthening, Protective, Clarifying, Anti-Aging, Anti-Acne, Anti-Irritant

*MEDICINAL: Anti-Microbial, Anti-Inflammatory, Anti-Oxidant, Regulative, Preventative, Energy Aid, Digestive Aid, Weight Reduction.
Used in aromatherapy and massage applications, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) functions as an ideal carrier oil for essential oils due to its easy-to-use liquid state and mild odor.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is popular amongst massage therapists due to its quick-absorbing, non-greasy, and non-staining properties.

Used in skincare, haircare, and cosmetic products, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) provides a light and highly stable moisturizing base that carries neutral sensory characteristics (odor and color), thus contributing to a positive consumer experience.
Formulators who wish to avoid the 'heavy' or 'nutty' smells associated with virgin or unprocessed botanical oils will find the very light characteristic scent of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) highly desirable, and it also provides a good alternative for Mineral Oil.

In addition, due to its non-oily, more powdery texture, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can enhance the consistency of an emulsion which can add to the performance perception by the consumer and is also ideal in rinse-off products.
Similarly, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is excellent in volumizing hair care formulations as the use of 'heavier' oils often tend to weigh the hair down and counteract the volumizing effect.

Unlike Coconut Oil, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is also non-comedogenic, suitable for all skin types, and can be used in applications such as oil cleansing.
Used in medicine and nutrition, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) has built a reputation of being a more potent, easily absorbed, rapidly digested dietary product that can be useful for those with nutritional or lipid metabolism disorders.

Unlike other fats, MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) display an unconventional metabolic pathway. Through the portal vein, they reach the liver directly and undergo oxidation to eventually produce ketones.
This rapidly occurring process, bypassing the natural, more time-consuming digestive process, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is regarded to be highly beneficial for energy, fitness, and weight loss.



HOW IS MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) MADE?
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can be made from both Coconut or Palm Oil, as they are both rich sources of the required medium-chain fatty acids.
Crude Coconut Oil or Palm Oil first undergoes hydrolysis, which essentially separates the fatty acids from the glycerol 'backbone' within their fat compounds.

The fatty acids can then be separated based on their boiling points through fractional distillation.
As medium-chain fatty acids have lower boiling points than long-chain fatty acids, they can be collected by heating and allowing to cool at appropriate temperatures.

Once the medium-chain fatty acids are isolated, they are combined with glycerol once again to form MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) in a process known as esterification.
This is a dehydration synthesis reaction, in which two compounds fuse together to produce water as a by-product.

A catalyst may be used, although it is not necessary.
As this is a highly targeted process, the desired ratios of C8 and C10 can be used in esterification.

Thus, in an MCT 60/40 oil, 60% of the fatty acids used will be Caprylic Acid (C8) and 40% will be Capric Acid (C10).
Finally, filtering and deodorization take place to clean and improve the sensorial characteristics of the resulting MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).



WHY DO WE USE MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) IN FORMULATIONS?
Why do we use it in formulations?
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are inexpensive and lightweight with little to no scent.
I like MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) in products like cleansing oils and balms, which are wash-off products.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can also be a good base for massage products, and works well as a simple base for blends of more expensive oils in facial serums.



DO YOU NEED MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE)?
No, but I really like it—MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is versatile and inexpensive.



MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE), REFINED OR UNREFINED?
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) only exists as a refined product



STRENGHTS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is inexpensive, lightweight.



WEAKNESSES OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is possibly not considered totally “natural”.



ALTERNATIVES AND SUBSTITUTIONS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Other lightweight, inexpensive oils like fractionated coconut oil, grapeseed oil, safflower oil, or sunflower oil would be good choices.



HOW TO WORK WITH MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Include in the oil phase of your products; if can be hot or cold processed, as needed.



STORAGE AND SHELF LIFE OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Stored somewhere cool, dark, and dry, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) should last at least two years.



TIPS, TRICKS, AND QUIRKS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Fractionated coconut oil and MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) are not the same thing.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are just the medium chain triglycerides found in coconut oil (caprylic/capric triglyceride while fractionated coconut oil is coconut oil without the long chain triglycerides, but still containing short and medium chain triglycerides.

This distinction is rarely important, though it is very important to anyone who suffers from fungal acne.
Despite the “not-the-same-thing” thing, you will very often find them sold as if they are.
This usually takes the form of MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) being sold as fractionated coconut oil (they’re often both listed on the label as if they are synonyms).



MECHANISM OF ACTION OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are broken down into glycerol and medium-chain fatty acids, which are directly absorbed into the blood stream and transported to the target organs, where they undergo β-oxidation to form acetyl-CoA.
The β-oxidation is the most common mechanism of action for energy production derived from fatty acid metabolism.

Because medium-chain fatty acids are rapidly oxidized, it leads to greater energy expenditure
Fatty acids are important substrates for energy production and also play a critical role in membrane structure and function.
Additionally, fatty acids act as precursors for bioactive molecules (such as prostaglandins) and as regulators of gene expression.

Fatty acids may mediate their effects on energy expenditure, food consumption, and fat deposition by upregulating the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism via activating Akt and AMPK signaling pathways and inhibiting the TGF-β signaling pathway.
It is proposed that the promotion of weight loss by MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) may be due to sympathetic activation of brown fat thermogenesis.



ABSORPTION, MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are rapidly absorbed.
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) passively and directly diffuse across the gastrointestinal tract into the portal system then to liver, where they are oxidized.



VOLUME OF DISTRIBUTION, MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
The apparent volumes of distribution have been researched as approximately 4.5 L for MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) and 19 L for medium chain fatty acids in a typical 70-kg subject.



PROTEIN BINDING, MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) bind weakly to serum albumin.
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) can readily cross the blood-brain barrier



METABOLISM OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are hydrolyzed by lipoprotein lipase to glycerol and medium-chain free fatty acids such as alpha-linolenic acid and linoleic acid.
Free fatty acids then undergo β-oxidation in the organs such as the liver, kidneys, and heart.

Alpha-linolenic acid and linoleic acid are metabolized within a common biochemical pathway through a series of desaturation and elongation steps.
Downstream products of alpha-linolenic acid are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and linoleic acid is converted to arachidonic acid.



IS THERE A DIFFERENCE BETWEEN MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) AND FRACTIONATED COCONUT OIL?
MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) derived from Coconut Oil may be called Fractionated Coconut Oil.
However, MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is important to note that the term 'Fractionated Coconut Oil' can also refer to a product in which Coconut Oil has undergone simple fractionation to remove its long-chain fatty acids; in other words, there is no esterification involved.

Thus, in this case, Fractionated Coconut Oil can be defined as simply a fraction of the fixed oil, but MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is in fact an ester and no longer carries an 'oily' feel.
This difference is reflected in their INCI names: Fractionated Coconut Oil remains 'Cocos Nucifera (Coconut) Oil' while MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) (both Palm or Coconut-derived) becomes 'Caprylic/Capric Triglycerides'.

As Fractionated Coconut Oil (Cocos Nucifera Oil) is also high in MCTs, its physical and chemical characteristics can be very similar to MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride).
However, as MCT - Medium Chain Triglyceride (Caprylic / Capric Triglyceride) is an ester, it has an even lighter, more powdery, non-oily texture and has a faster absorbency speed compared to Fractionated Coconut Oil.



HEALTH BENEFITS OF MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
Because MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are so easily absorbed, they have been used clinically since the 1950s in cases of pancreatic insufficiency, fat malabsorption and in total parenteral nutrition.
Later MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) were added to preterm infant formulas.
More recently, MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) have drawn the attention of athletes and those looking to enhance their production of ketones.



HOW DOES MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE) WORK?
MCT - Medium Chain Triglycerides (Caprylic / Capric Triglyceride) are a fat source for patients who cannot tolerate other types of fats.
Researchers also think that these fats produce chemicals in the body that might help fight Alzheimer's disease.



PHYSICAL and CHEMICAL PROPERTIES of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
density: 0.94-0.96
vapor pressure: 0-0Pa at 20℃
solubility: Soluble in all proportions at 20°C in acetone, benzene, 2-butanone, carbon tetrachloride, chloroform, dichloromethane, ethanol, ethanol (95%), ether, ethyl acetate, petroleum ether, special petroleum spirit (boiling range 80–110°C), propan- 2-ol, toluene, and xylene. Miscible with long-chain hydrocarbons and triglycerides; practically insoluble in water.
form: Liquid
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 269.00 to 270.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.003550 mmHg @ 25.00 °C. (est)
Flash Point: 251.00 °F. TCC ( 121.80 °C. ) (est)
logP (o/w): 3.965 (est)
Soluble in: water, 0.06951 mg/L @ 25 °C (est)
Insoluble in: water



FIRST AID MEASURES of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Rresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available



SYNONYMS:
1,2,3-Propanetriol Trioctanoate
AC-1202
Acide Caprique
Acide Caprylique
Acide Laurique
Capric Acid
Caproic Acid
Caprylic Acid
Caprylic Triglycerides
Lauric Acid
MCT
MCT's
MCTs
Medium-Chain Triacylglycerols
Medium-Chain Triglycerides, TCM
Tricaprylin
Trioctanoin
Medium chain triglycerides powder
MCT powder



MEA LAURYL SULFATE
MEA-LAURYL SULFATE, N° CAS : 4722-98-9, Nom INCI : MEA-LAURYL SULFATE, Nom chimique : (2-Hydroxyethyl)ammonium dodecylsulphate, N° EINECS/ELINCS : 225-214-3, Classification : ,Sulfate, Règlementé, MEA. Restriction en Europe : III/61. Ses fonctions (INCI). Agent nettoyant : Aide à garder une surface propre. Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation
Meadowfoam Delta-Lactone
6-pentadecyltetrahydropyran-2-one; cyclic ester formed from meadowfoam (limnanthes alba) seed oil fatty acids; Meadowlactone CAS NO:110071-67-5
Meadowfoam estolide
5-(5-eicosenoyloxy)eicosanoic acid; Meadowfoam Seed Oil; Fatty acids, vegetable-oil, polymd., unreacted fraction CAS NO:68937-92-8
Meadowfoamamidopropyl Betaine
BETAFAN M; MEADOWFOAMAMIDOPROPYL BETAINE; betaine; meadowfoamamido proylbetain; 2-[(3-Dodecanamidopropyl)dimethylaminio]acetate CAS NO:61789-40-0
MEDIALAN LD
Anionic surfactant for the cosmetic industry MEDIALAN LD Composition Lauroyl sarcoside sodium salt MEDIALAN LD INCI name Sodium Lauroyl Sarcosinate MEDIALAN LD PRODUCT PROPERTIES1 MEDIALAN LD Appearance (20 °C) clear, liquid MEDIALAN LD Iodine colour number max. 1.0 MEDIALAN LD pH-value (1 % water solution) 7.0 – 8.5 MEDIALAN LD solid content 29.0 – 31.0 % MEDIALAN LD Average molecular weight 293 g/mol MEDIALAN LD Manufacture Reaction of coconut fatty acid chloride with sarcosin (Schotten Baumann). Neutralisation with NaOH. MEDIALAN LD Profile Because of its excellent physiological properties and neutral taste MEDIALAN LD is widely used as a foaming agent in dental care preparations, especially in toothpastes. The concentration of MEDIALAN LD in toothpastes is usually in the range of 1 % to 6 %. As a liquid, MEDIALAN LD does not cause troublesome dusting in processing. MEDIALAN LD combines a good cleansing action with relatively weak degreasing. Thus for the manufacture of hair shampoos and body cleansing products MEDIALAN LD is often best combined as mild co-surfactant with alkyl ether sulphates. MEDIALAN LD Foaming behaviour MEDIALAN LD has very good foaming properties especially in soft water and displays interesting synergistic and foam-stabilising properties when combined with other surfactants, e.g. alkyl ether sulphates. The foaming behaviour of MEDIALAN LD also depends on the pH of the finished product. It is usually worthwhile to adjust the formulations to a slightly acid pH of between 5.5 and 6.5, for instance with citric acid. Foam stability in relation to time is also considerably better in the weakly acid than in the alkaline pH range. Compared with some other surfactants, MEDIALAN LD has excellent foaming power in electrolyte-containing solutions.
MEDIALAN LD PF10
DESCRIPTION:
Medialan LD PF 10 is the perfect choice for cleaning products without harsh labelling and high cleaning performance.
Medialan LD PF 10 is mild to both skin and the environment.
Medialan LD PF 10 is an anionic surfactant for the cosmetic industry.


CAS Number: 137-16-6, 7732-18-5, 55965-84-9
EINECS/ELINCS No: 205-281-5, 231-791-2, 611-341-5


CHEMICAL AND PHYSICAL PROPERTIES OF MEDIALAN LD PF10:
Chemical name: Sodium Lauroyl Sarcosinate
Claims:
Surfactants / Cleansing Agents > Anionics > Alkyl Sarcosinates
foam booster
INCI Names:
SODIUM LAUROYL SARCOSINATE
AQUA
METHYLCHLOROISOTHIAZOLINONE
Chemical Composition: Fatty acid sarcoside sodium salt
CAS Number: 137-16-6, 7732-18-5, 55965-84-9
Use Level: 1-6%
EINECS/ELINCS No: 205-281-5, 231-791-2, 611-341-5
Appearance: Liquid, clear
Odor: Characteristic
Color: Yellow
Product Status: COMMERCIAL


APPLICATIONS OF MEDIALAN LD PF10:
Medialan LD PF 10 is widely used as a foaming agent in dental care preparations, especially in toothpastes.
Medialan LD PF 10 combines a good cleansing action with relatively weak degreasing.
Therefore, when manufacturing hair shampoos and body cleansing products, Medialan LD PF 10 is best combined as mild co-surfactant with alkyl ether suphates.

Medialan LD PF 10 is Sodium Lauroyl Sarcosinate (and) Aqua (and) Methylchloroisothiazolinone.
Medialan LD PF 10 is a plant-based, anionic, mild surfactant.
Medialan LD PF 10 Exhibits good cleansing action with relatively weak degreasing.

Medialan LD PF 10 is best combined as mild co-surfactant with alkyl ether suphates.
Medialan LD PF 10 is Used as a foaming agent in dental care preparations especially in toothpastes.
Medialan LD PF 10 Also exhibits good skin and mucous membrane compatibility, good odor, taste neutrality and interesting synergistic properties.

Medialan LD PF 10 depends on the pH of the finished product and is cold processable, easy to use, electrolyte tolerant and foam booster.
Medialan LD PF 10 is suitable for clear formulations.
Medialan LD PF 10 is Also used in shower, liquid soap, shampoo, wet wipe and hair styling products.

Medialan LD PF 10 is used as Hard surface cleaning
Medialan LD PF 10 is used as Hand dishwashing
Medialan LD PF 10 is used as Laundry pre-treatment
Medialan LD PF 10 is used as Laundry liquid detergents


PERFORMANCE CLAIMS:
Detergency booster
Highly biodegradable
Superior ecological profile
Mild to skin


SAFETY INFORMATION ABOUT MEDIALAN LD PF10:

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.





MEDIALAN LD PF10 (SODIUM LAUROYL SARCOSINATE)


Medialan LD PF10 is a chemical ingredient that is also known by its common name, Sodium Lauroyl Sarcosinate.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a water-soluble, anionic surfactant that belongs to the class of sarcosinates.
Sarcosinates are derived from sarcosine, an amino acid. Sodium Lauroyl Sarcosinate is widely used in personal care and cosmetic products for its surfactant properties.

CAS Number: 137-16-6
EC Number: 205-290-4

Sodium Lauroyl Sarcosinate, Medialan LD PF10, Sarcosinate de Sodium Lauroyl, N-Lauroylsarcosinate de sodium, Sodio Lauroil Sarkozinat, Natriumlauroylsarkosinat, Nátrium-lauril-szarkozinát, Lauriinsarkosiininatrium, Laurilsarkozinaat Natrium, Sodium Lauroyl Sarcosinato, Sodio Lauril Sarkozinato, Sodium Lauroylsarkosinaat, Sodium Lauroylsarkosinate, Nátrium-laurylszarkoszinát, Natrium Lauroyl Sarcosinat, Sodium Lauroylsarkosinaatti, Sodium Lauroylsarkosinat, Sodium Lauryl Sarcosinate, Sodium N-Lauroylsarcosinate, Sodium Sarcosinate Lauroyl, Sodiu Lauroylsarcosinat, Nátrium-lauril-szarkozinát, Sodná soľ lauroylsarkosinátu, Nátrium-sarcosinate laurylu, Sarcosinato de Sodio Lauroilo, Sodium N-Lauroylsarcosinate, Sodium Lauroylsarkosinat, Sodium Lauroylsarkosinate, Sodium Lauryl Sarcosinate, Sodium Laurylsarcosinate, Sodium N-Lauroylsarcosinate, Sodium Sarcosinate Lauroyl, Sodiu Lauroylsarcosinat, Nátrium-lauril-szarkozinát, Sodná soľ lauroylsarkosinátu, Nátrium-sarcosinate laurylu, Sarcosinato de Sodio Lauroilo, Sodium N-Lauroylsarcosinate, Sodium Lauroylsarkosinat, Sodium Lauroylsarkosinate, Sodium Lauryl Sarcosinate, Sodium Laurylsarcosinate, Sodium N-Lauroylsarcosinate, Sodium Sarcosinate Lauroyl, Sodiu Lauroylsarcosinat, Nátrium-lauril-szarkozinát, Sodná soľ lauroylsarkosinátu, Nátrium-sarcosinate laurylu, Sarcosinato de Sodio Lauroilo, Sodium N-Lauroylsarcosinate, Sodium Lauroylsarkosinat, Sodium Lauroylsarkosinate, Sodium Lauryl Sarcosinate, Sodium Laurylsarcosinate, Sodium N-Lauroylsarcosinate, Sodium Sarcosinate Lauroyl.



APPLICATIONS


Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is extensively used in shampoos for its ability to create a rich and stable lather during hair cleansing.
In facial cleansers, Medialan LD PF10 (Sodium Lauroyl Sarcosinate) contributes to the formulation by providing effective cleansing without causing irritation to the skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a key ingredient in body washes, where it ensures a mild and pleasant cleansing experience.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is commonly found in toothpaste formulations, where it aids in the even distribution of active ingredients for thorough cleaning.
Its mild cleansing properties make it suitable for baby care products such as gentle shampoos and body washes.
In shaving creams and foams, it helps in creating a creamy texture and enhancing the overall shaving experience.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in facial scrubs and exfoliating products to improve the spreadability and effectiveness of exfoliating particles.
In hand soaps and liquid hand washes, it contributes to foaming and cleansing properties, leaving hands feeling clean and refreshed.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is employed in intimate washes, providing mild and non-irritating cleansing for sensitive areas.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a common ingredient in mild and hypoallergenic formulations designed for individuals with sensitive or reactive skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in personal care formulations targeting individuals with skin conditions such as eczema or dermatitis.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate)'s compatibility with other surfactants makes it valuable in the formulation of complex emulsions and cream-based products.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in cosmetic wipes and towelettes for its contribution to effective and gentle makeup removal.
In sunscreen formulations, it aids in the dispersion of UV-filtering agents, ensuring even coverage on the skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) finds application in antiperspirant and deodorant formulations, contributing to the spreadability of active ingredients.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is employed in formulations for color-treated hair products, providing mild cleansing without stripping away color.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in formulations targeting oily or acne-prone skin, as it helps in balancing sebum production without causing excessive dryness.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is incorporated into mouthwash formulations to enhance the overall cleansing and refreshing effect.
In bath products such as bath foams and bubble baths, it contributes to a luxurious and foamy bathing experience.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in pet shampoos, ensuring a gentle cleansing experience for animals with sensitive skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is found in certain pharmaceutical formulations, providing a mild surfactant for oral care and dermatological products.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in intimate hygiene products, contributing to formulations that prioritize mildness and skin comfort.
In cosmetic emulsions such as creams and lotions, it acts as an emulsifying agent to ensure proper dispersion of water and oil phases.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is employed in natural and organic formulations as a preferred mild surfactant option.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in various personal care and cosmetic products where a balance between effective cleansing and skin-friendliness is essential.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a crucial component in gentle facial cleansing wipes, ensuring effective makeup removal without causing irritation.
In acne treatment formulations, it is utilized for its ability to cleanse excess oils and impurities without aggravating acne-prone skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is incorporated into micellar water formulations, enhancing the product's ability to lift away dirt and makeup with ease.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) finds application in men's grooming products, contributing to the creamy lather and smooth texture of shaving creams.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in exfoliating scrubs to aid in the even distribution of exfoliating particles, promoting a smoother and more refined skin texture.
In natural and organic personal care products, it serves as a preferred surfactant option due to its mild and eco-friendly properties.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is added to facial masks, enhancing their cleansing and purifying effects while maintaining a gentle touch on the skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in clarifying shampoos, effectively removing product buildup and excess oils from the hair and scalp.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) contributes to the formulation of baby wipes, ensuring a mild and non-irritating solution for delicate baby skin.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is employed in sulfate-free formulations, providing a gentle alternative to traditional sulfate-based surfactants.
In hand sanitizers, it enhances the cleansing efficacy and contributes to the product's overall skin feel.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in pre-shave and post-shave products, contributing to a smooth and comfortable shaving experience.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is added to foam cleansers, generating a luxurious foam that effectively lifts away impurities.
In anti-dandruff shampoos, it aids in cleansing the scalp and controlling dandruff without causing excessive dryness.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is found in certain pharmaceutical formulations, providing a mild surfactant for oral care products such as mouthwashes and toothpaste.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in gentle eye makeup removers, ensuring effective removal of eye makeup without stinging or irritation.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is added to bath oils, contributing to a soothing and foamy bath experience while maintaining skin-friendly properties.
In cream-based makeup formulations, it acts as an emulsifying agent, ensuring a smooth and uniform texture.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is employed in color cosmetics, contributing to the formulation of creamy and easy-to-apply products.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in sensitive skin formulations, providing effective cleansing in products designed for individuals with reactive or delicate skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is included in formulations for intimate hygiene products, maintaining a gentle and pH-balanced solution.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) contributes to the creation of mild and tear-free baby shampoos, prioritizing the comfort of infants.

In natural deodorant formulations, it assists in the even distribution of active ingredients for effective odor control.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in facial toners, aiding in the removal of residual impurities while maintaining a refreshing sensation.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is found in microneedling aftercare products, providing a gentle cleansing solution for treated skin.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a key ingredient in sulfate-free baby shampoos, ensuring a gentle and tear-free cleansing experience for infants.
In natural and organic facial cleansers, it serves as a mild surfactant option that aligns with clean beauty formulations.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in anti-aging skincare products, contributing to the effectiveness of cleansers and exfoliating solutions.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is incorporated into liquid soaps for hand hygiene, providing an effective and pleasant handwashing experience.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is added to clarifying hair masks to enhance their cleansing properties and maintain a soft and manageable texture for the hair.
In hair color removal products, the surfactant aids in breaking down and removing residual color without excessive damage to the hair.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is found in mild facial peels, contributing to the even application and removal of the peel solution.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in body exfoliating scrubs, helping to disperse exfoliating particles for thorough skin renewal without causing irritation.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is included in micellar cleansing waters, providing an effective and gentle solution for removing impurities from the skin.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) contributes to the formulation of sulfate-free body washes, ensuring a mild and refreshing shower experience.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in facial serums and toners, aiding in the removal of residual impurities and preparing the skin for further skincare products.
In natural deodorant sticks, the surfactant assists in the even distribution of odor-controlling ingredients for long-lasting freshness.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is added to bath salts, contributing to a luxurious bath experience while maintaining skin-friendly properties.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is found in mild exfoliating foot scrubs, promoting the removal of dead skin cells without harsh abrasion.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in men's grooming products such as facial cleansers and scrubs for a thorough yet gentle skincare routine.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) contributes to the formulation of sulfate-free hand creams, ensuring effective moisturization without greasiness.
In intimate wash gels, the surfactant provides a mild and non-irritating solution for maintaining intimate hygiene.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is included in sulfate-free hair conditioners, contributing to the overall conditioning effect while preserving hair color.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in pre-waxing cleansers, preparing the skin for hair removal procedures without causing irritation.

In gentle microneedling solutions, the surfactant aids in the preparation and cleansing of the skin before microneedling treatments.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in sulfate-free hair styling gels, contributing to the formulation's ability to provide hold without residue buildup.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is added to sulfate-free leave-in hair conditioners, ensuring easy application and effective detangling.
In facial mists and toning sprays, the surfactant aids in maintaining a balanced skin pH and refreshing the skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is included in sulfate-free facial masks, contributing to the formulation's ability to cleanse and purify the skin.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is utilized in sulfate-free acne treatment cleansers, providing an effective solution without aggravating sensitive or acne-prone skin.



DESCRIPTION


Medialan LD PF10 is a chemical ingredient that is also known by its common name, Sodium Lauroyl Sarcosinate.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a water-soluble, anionic surfactant that belongs to the class of sarcosinates.
Sarcosinates are derived from sarcosine, an amino acid. Sodium Lauroyl Sarcosinate is widely used in personal care and cosmetic products for its surfactant properties.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a water-soluble surfactant commonly used in personal care products.
This chemical, also known as Medialan LD PF10, belongs to the family of sarcosinates.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is characterized by its mild cleansing properties, making it suitable for gentle formulations.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is derived from sarcosine, an amino acid.
As a surfactant, it reduces the surface tension of liquids, aiding in effective cleansing.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is widely employed in the cosmetic and personal care industry for its foaming capabilities.
Medialan LD PF10 contributes to the formation of stable and creamy lather in cleansing products.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is known for providing a gentle cleansing experience without causing excessive dryness.

Sodium Lauroyl Sarcosinate is often used in shampoos, body washes, facial cleansers, and toothpaste.
With its biodegradable nature, it aligns with environmentally friendly formulation practices.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is compatible with a range of other surfactants, enhancing overall product performance.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) exhibits good solubility in water, contributing to its ease of formulation.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is a favored choice in products requiring mild and non-irritating cleansing.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is commonly used in formulations targeting sensitive skin due to its gentle nature.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is effective in creating stable emulsions and maintaining product stability.
Its versatility allows for application in a variety of cosmetic and personal care formulations.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) acts as an emulsifying agent, ensuring proper mixing of ingredients.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used to enhance the spreadability and foam quality in cosmetic and personal care products.
Known for its compatibility with various materials, it contributes to the overall formulation integrity.

In toothpaste formulations, it aids in the even distribution of ingredients for effective cleaning.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) undergoes thorough testing to ensure its safety and efficacy in personal care products.

Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is used in products where a balance between cleansing efficacy and skin-friendliness is crucial.
Medialan LD PF10 (Sodium Lauroyl Sarcosinate) is often included in formulations targeting both adult and baby care products.
With its stable properties, Sodium Lauroyl Sarcosinate helps maintain the quality of cosmetic formulations over time.
Medialan LD PF10 is valued for its contribution to the creation of cosmetic and personal care products that prioritize a mild and enjoyable user experience.



PROPERTIES


Chemical Name: Sodium Lauroyl Sarcosinate
Common Name: Medialan LD PF10
Chemical Formula: C₁₃H₂₅NO₃Na (sodium salt of lauroyl sarcosine)
CAS Number: 137-16-6
EC Number: 205-290-4


Physical Properties:

Physical State: Solid (powder or flakes) or liquid (depending on formulation)
Color: White to light yellow
Odor: Characteristic
Solubility: Highly soluble in water



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air.
If respiratory distress persists, seek medical attention.


Skin Contact:

In case of skin contact, immediately remove contaminated clothing.
Wash the affected area with plenty of soap and water.
If irritation or redness persists, seek medical advice.


Eye Contact:

In case of eye contact, immediately flush eyes with plenty of water for at least 15 minutes, lifting the upper and lower eyelids.
Seek medical attention if irritation persists.


Ingestion:

If swallowed, do not induce vomiting unless directed by medical personnel.
Rinse the mouth with water and seek medical attention.
If the person is conscious, provide small sips of water.


Note to Physicians:

No specific antidote is known.
Treat symptomatically based on the individual's presentation and clinical condition.
Provide supportive care as necessary.


General Advice:

Keep the affected person calm.
Obtain medical attention if any adverse effects occur.
Do not administer anything orally unless directed by medical personnel.


Extinguishing Media:

Use suitable extinguishing media based on the surrounding fire conditions (water spray, foam, dry chemical, or carbon dioxide).



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear suitable protective clothing, including chemical-resistant gloves and safety goggles, to prevent skin and eye contact.
Use respiratory protection, such as a mask, if handling the substance in an environment with inadequate ventilation.

Ventilation:
Ensure adequate ventilation in the handling area to prevent the accumulation of vapors or dust.
Implement local exhaust systems if necessary.

Avoidance of Contact:
Avoid direct skin contact and inhalation of vapors or dust.
Use appropriate engineering controls, such as closed systems or local exhaust, to minimize exposure.

Hygiene Practices:
Wash hands thoroughly after handling.
Do not eat, drink, or smoke while working with the substance.
Implement good industrial hygiene practices in the workplace.

Storage Compatibility:
Store Sodium Lauroyl Sarcosinate away from incompatible substances, including strong acids, strong bases, and oxidizing agents.
Keep away from sources of heat and direct sunlight.


Storage:

Storage Conditions:
Store Sodium Lauroyl Sarcosinate in a cool, dry, and well-ventilated area.
Keep the substance in its original container or a suitable, tightly closed container.

Temperature Control:
Avoid exposure to extreme temperatures.
Maintain storage temperatures within the specified range provided by the manufacturer.

Container Material:
Use containers made of materials compatible with the substance (e.g., high-density polyethylene or glass).
Ensure containers are tightly closed when not in use.

Preventive Measures:
Implement measures to prevent accidental releases and spills.
Provide suitable containment measures, such as spill kits, in the storage area.

Segregation:
Store Sodium Lauroyl Sarcosinate away from food and feedstuffs.
Segregate from incompatible substances to prevent potential reactions.

Labeling:
Ensure proper labeling of containers with relevant hazard information.
Clearly mark storage areas with appropriate signage.

Security Measures:
Implement security measures to prevent unauthorized access to the storage area.

Handling Equipment:
Use handling equipment, such as pumps or scoops, designed for the safe transfer of the substance.

Monitoring:
Regularly monitor storage conditions and inspect containers for damage or leaks.

MEDIUM CHAIN TRIGLYCERIDES
MEDIUM CHAIN TRIGLYCERIDES


CAS Number: 65381-09-1/73398-61-5
EC Number : 277-452-2


Medium-chain triglycerides (MCTs) are triglycerides with two or three fatty acids having an aliphatic tail of 6–12 carbon atoms, i.e. medium-chain fatty acids (MCFAs).
Medium-chain triglycerides are a class of fatty acids.
Their chemical composition is of a shorter length than the long-chain fatty acids present in most other fats and oils, which accounts for their name.


Medium Chain Triglycerides are also different from other fats in that they have a slightly lower calorie content and they are more rapidly absorbed and burned as energy, resembling carbohydrate more than fat.
Medium Chain Triglycerides, more commonly referred to as MCTs, have made quite a splash in the nutrition world and with good reason—they are pretty amazing fats.
To understand what a medium chain triglyceride is, it is helpful to first understand the chemical structure of fats.


The fats we find in nature are generally triglycerides, which consist of three fatty acids attached to a glycerol backbone.
The fatty acids themselves are chains of carbon atoms varying in length from 4 carbons to 26 or more, commonly classified as short, medium and long chain.
In nature the fatty acids that make up a triglyceride are usually a combination of different length fatty acids and not three of the same length.


So a naturally occurring triglyceride is some combination of short, medium and long chain fatty acids.
Medium Chain Triglycerides are a class of fatty acids.
Medium Chain Triglycerides's chemical composition is of a shorter length than the long-chain fatty acids present in most other fats and oils, which accounts for their name.


Medium Chain Triglycerides are also different from other fats in that they have a slightly lower calorie content1 and they are more rapidly absorbed and burned as energy, resembling carbohydrate more than fat.
Rich food sources for commercial extraction of Medium Chain Triglycerides include palm kernel oil and coconut oil.
Medium Chain Triglycerides are metabolized differently


Given the shorter chain length of Medium Chain Triglycerides, they’re rapidly broken down and absorbed into the body.
Unlike longer-chain fatty acids, Medium Chain Triglycerides go straight to your liver, where they can be used as an instant energy source or turned into ketones.
Ketones are substances produced when the liver breaks down large amounts of fat.


Medium Chain Triglycerides are naturally occurring fatty acids that can be very easily used by the body for energy.
Medium Chain Triglycerides work much like a carbohydrate in that they’re a readily available energy source but unlike carbs, MCTS can also aid in fat loss and lean muscle growth.
Medium Chain Triglycerides are a popular supplement for those opting for higher fat diets such as keto.


Medium Chain Triglycerides are fats that are naturally found in coconut and palm kernel oil.
Medium Chain Triglycerides are more easily and rapidly digested than other types of fats, as they require lower amounts of enzymes and bile acids for intestinal absorption.
Medium Chain Triglyceridesare metabolized very quickly in the liver and are reported to encourage an increase in energy expenditure, while decreasing fat storage.


Numerous studies suggest that substituting Medium Chain Triglycerides Oil for other fats in a healthy diet may therefore help to support healthy weight and body composition.
Medium chain triglycerides is a medical food derived from fatty acids and safflower oil, a polyunsaturated fat.
Medium chain triglycerides does not contain protein or carbohydrates.


Store medium chain triglycerides at room temperature away from moisture and heat.
Medium-chain triglycerides are partially man-made fats.
The name refers to the way the carbon atoms are arranged in their chemical structure.
Medium Chain Triglycerides are generally made by processing coconut and palm kernel oils in the laboratory.


Medium Chain Triglycerides contain fatty acids that have a chain length of 6-12 carbon atoms.
The name refers to the way the carbon atoms are arranged in their chemical structure.
Medium Chain Triglycerides are generally made by processing coconut and palm kernel oils.
Medium Chain Triglycerides oil is a concentrated source of medium-chain triglycerides.


Medium‐chain triglycerides are a type of fat which contain medium chain fatty acids.
Medium‐chain fatty acids contain between 8 to 12 carbon atoms in their fatty acid chains and are typically saturated.
Medium Chain Triglycerides are usually very limited in western diets with coconut and palm being the only rich sources.
The predominant form of fat in western diets is long‐chain triglyceride (LCT) which contain at least 14 carbon atoms in their fatty acid chains and can be saturated, polyunsaturated or monounsaturated.


Furthermore, one of the benefits of supplementing with Medium Chain Triglycerides oil is that it can easily be incorporated into a person’s daily diet.
Since Medium Chain Triglycerides comes in liquid form and is virtually odorless and tasteless, it can be easily added to other foods, such as shakes, coffee or broth, that are already part of typical meals.


Substituting it for other oils in homemade salad dressings is another simple way to ingest Medium Chain Triglycerides oil without the need for specialized recipes.
While it can be used as a cooking oil, it’s best to avoid doing so as Medium Chain Triglycerides oil has a low smoke point.
Medium Chain Triglycerides are triglycerides made up of a glycerol backbone and three fatty acids with an aliphatic tail of six to 12 carbon atoms.


Medium Chain Triglyceridesare found in natural foods, such as coconut oil, palm kernel oil, and raw coconut meat.
In the body, Medium Chain Triglyceridesare broken down into glycerol and free fatty acids, which are directly absorbed into the blood stream and transported to the target organs to exert a range of biological and metabolic effects.
Medium-chain triglycerides (MCTs), in combination with other compounds like fish oils, soya oil, and olive oil, is indicated in adult and pediatric patients, including term and preterm neonates, as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.


Medium Chain Triglycerides are actually types of saturated fat; therefore they contribute to the saturated fat content of a food as labeled, despite not being treated like other saturated fats in the body.
As Medium Chain Triglycerides are saturated fats, they are not oxidized.
Medium Chain Triglycerides are a versatile single or blend of saturated medium-chain-length fatty acids derived from renewable natural sources.
It can be easily absorbed and transported throughout the human body compared to long-chain triglycerides (LCTs).


Medium Chain Triglycerides are naturally occurring fatty acids that can be very easily used by the body for energy.
Medium Chain Triglycerides are generally considered a good biologically inert source of energy that the human body finds reasonably easy to metabolize.
Medium Chain Triglycerides have potentially beneficial attributes in protein metabolism, but may be contraindicated in some situations due to a reported tendency to induce ketogenesis and metabolic acidosis.


However, there is other evidence demonstrating no risk of ketoacidosis or ketonemia with Medium Chain Triglycerides at levels associated with normal consumption, and that the moderately elevated blood ketones can be an effective treatment for epilepsy.
Medium Chain Triglycerides are an ingredient in some specialised parenteral nutritional emulsions in some countries.
Medium Chain Triglycerides are fats that are made in a lab from coconut and palm kernel oils.


Typical dietary fats are called long-chain triglycerides.
In coconut oil, about half of the fatty acids are lauric acid.
Dairy products, on the other hand, contain primarily caprylic and capric acid and have lower concentrations of lauric acid.
However, palm and coconut oil still contain more Medium Chain Triglycerides than dairy products.


This is why they are the primary source for Medium Chain Triglycerides oil even though they contain a lower concentration of the caprylic and capric acid used for MCT oil.
Medium Chain Triglycerides are a fat source for people who cannot tolerate other types of fats.
These fats might also improve weight loss because the body can more easily break them down into molecules called ketone bodies.
These ketone bodies can be used for energy.


Because the calories contained in Medium Chain Triglycerides are more efficiently turned into energy and used by the body, they’re less likely to be stored as fat.
If there’s an excess of Medium Chain Triglycerides, they too will eventually be stored as fat.
Medium-chain triglycerides are a type of saturated fat composed of fatty acids with 6–10 carbons in their acyl chain.


Medium Chain Triglycerides are found primarily in coconut oil, palm kernel oil, and dairy fat, and they appear to benefit fat loss to a minor extent when consumed in place of other dietary fat.
Medium-chain triglycerides (MCTs) are a type of fat found in oils, such as coconut and palm oil.
In recent years, Medium Chain Triglycerides oil gained popularity as a supplement, with research suggesting health benefits ranging from increased energy to appetite control.


Increased interest in Medium Chain Triglycerides oil’s benefits is partially due to the rise of the ketogenic diet and influx of research on the benefits of coconut oil.
Medium chain triglycerides (MCTs) are a class of lipids in which three saturated fats are bound to a glycerol backbone.
What distinguishes Medium Chain Triglycerides from other triglycerides is the fact that each fat molecule is between six and twelve carbons in length.


Medium Chain Triglycerides are a component of many foods, with coconut and palm oils being the dietary sources with the highest concentration of Medium Chain Triglycerides.
Medium Chain Triglycerides are also available as a dietary supplement.
MCT oil is 100% Medium Chain Triglycerides, making it the most concentrated source of MCTs when compared to other oils, like coconut or palm.


Medium Chain Triglycerides are also found in palm kernel oil, butter and other milk products like cheese.
Grass-fed butter is composed of approximately 8% Medium Chain Triglycerides.
Dairy products, like full-fat yogurt, have about 8% to 9% Medium Chain Triglycerides.
Medium Chain Triglycerides are in the form of saturated fatty acids.


The difference between MCT (Medium Chain Triglyceride) and LCT (Long Chain Triglyceride) is the length of their carbon chains.
Medium Chain Triglyceride has a chain length of six to twelve carbons.
LCTs have a carbon length of fourteen or more.
The length of the carbon chain determines the physical and chemical properties and metabolism of fats in the human body.


Medium Chain Triglycerides are available both naturally and synthetically.
Natural Medium Chain Triglycerides are most commonly found in coconut but also palm kernel oil, milk, cheese and butter.
SCT: Small Chain Triglycerides
MCT: Medium Chain Triglycerides
LCT: Long Chain Triglycerides


Medium-chain triglycerides (MCTs) have become popular among individuals who want to lose weight and among athletes.
Medium Chain Triglycerides are composed of fatty acids that contain between 6 and 12 carbon molecules.
We commonly consume foods high in long-chain triglycerides (LCTs) that have more than 12 carbon molecules.
Foods high in LCTs include nuts, seeds, avocados, fish, and meat; however, there are only a handful of foods that are high in Medium Chain

Triglycerides (human breast milk, cow’s milk, goat’s milk, coconut oil, palm kernel oil, coconut meat, and dried coconut).
Some studies have shown that Medium Chain Triglycerides can help in the process of excess calorie burning, thus weight loss.
Medium Chain Triglycerides are also seen as promoting fat oxidation and reduced food intake.
Medium Chain Triglycerides have been recommended by some endurance athletes and the bodybuilding community.


While health benefits from Medium Chain Triglycerides seem to occur, a link to improved exercise performance is inconclusive.
A number of studies back the use of Medium Chain Triglycerides oil as a weight loss supplement.
Triglycerides are composed of a glycerol “backbone” and three fatty acids attached to that glycerol backbone, hence the name “triglycerides” (the scientific and more appropriate name is actually “triacylglycerol”).
Furthermore, the fatty acids that make up a triglyceride can be monounsaturated, polyunsaturated, or saturated.


The saturation denotes the number of double bonds or “open spaces,” if you will, on each fatty acid.
In addition, every fat has some combination of monounsaturated, polyunsaturated, or saturated fatty acid.
However, it is the predominant type of fatty acid that defines each type of fat.
For example, olive oil has mostly monounsaturated fatty acids, soybean oil has mostly polyunsaturated fatty acids, and butter has mostly saturated fatty acids.


Medium Chain Triglycerides are incorporated into the intestinal mucosal cells without the need for intraluminal lipase or bile salt.
Medium Chain Triglycerides are a class of lipids in which three intermediate carbon length saturated fats are bound to a glycerol backbone; the structure is called triacylglycerols or triglycerides.
Medium Chain Triglyceridesare distinguished from other triacylglycerols in that each fat molecule is between six and twelve carbons in length


These differences in physical properties have led, since the 1960s, to the use of Medium Chain Triglycerides to improve various lipid absorption disorders and malnutrition.
More than half a century has passed since Medium Chain Triglycerideswere first used in the medical field.
It has been reported that they not only have properties as an energy source, but also have various physiological effects, such as effects on fat and protein metabolism.


The enhancement of fat oxidation through ingestion of Medium Chain Triglycerides has led to interest in the study of body fat reduction and improvement of endurance during exercise.
Recently, Medium Chain Triglycerides have also been shown to promote protein anabolism and inhibit catabolism, and applied research has been conducted into the prevention of frailty in the elderly.


An emphasis on low-carb diets and macronutrients has also driven the growth of medium-chain triglycerides in the food industry.
Medium-chain triglycerides, or MCTs, are metabolized more quickly than other fatty acids to provide energy without being stored as fat.
Medium Chain Triglycerides also provide many other health benefits that position them as a popular dietary supplement whose use is likely to continue to grow in the future.


Medium-chain triglycerides (MCTs) are fats that occur naturally in some foods, such as whole foods and dairy products, but they are also manufactured for their value as a healthier dietary fat.
Triglycerides are a chemical compound that is composed of a glycerol backbone and three fatty acids.
These fatty acids can have different numbers of carbon atoms attached to them, forming an aliphatic tail which determines the type of triglyceride.


Long-chain triglycerides (LCTs), which are the most common dietary fat, have 13 to 21 carbons in each aliphatic tail.
Short-chain triglycerides have fewer than six carbons attached to each fatty acid.
Medium-chain triglycerides fall right in the middle with an aliphatic tail of six to 12 carbon atoms on at least two out of three fatty acids.
Compared to LCTs, Medium Chain Triglycerides are easier for the body to metabolize quickly, meaning they are less likely to be stored as fat.
The body cannot metabolize LCTs as efficiently, and excess LCTs are stored as fat.


Medium Chain Triglycerides, on the other hand, can travel immediately to the liver after they are consumed to be used as instant energy.
Medium Chain Triglycerides can also be turned into ketones which can travel from the blood to the brain to serve as an alternative energy source to glucose.
Medium Chain Triglycerides are a specific fraction of coconut / palm oil fatty acids resulting in only the more stable, and skin loving oil.


Medium Chain Triglycerides are also known as MCT OIL.
Medium Chain Triglycerides are fats that are naturally found in coconut and palm kernel oils.
Medium Chain Triglycerides are more easily and rapidly digested than other types of fats.
Medium Chain Triglycerides are readily absorbed from the GI tract and are metabolized very quickly by the liver, where they are reported to encourage the use of fat for energy rather than for storage.


Numerous studies suggest that substituting Medium Chain Triglycerides Oil for other fats in a healthy diet may therefore help to support healthy weight and body composition.
Medium Chain Triglycerides are more easily and rapidly digested than other types of fats.
Medium Chain Triglycerides are readily absorbed from the GI tract and metabolized very quickly by the liver, where they are reported to encourage the use of fat for energy rather than for storage.


Medium Chain Triglycerides are fats that are metabolized differently than most dietary fats.
Unlike longer chain triglycerides, Medium Chain Triglycerides require little or no enzymatic breakdown and are easily absorbed across the wall of the small intestine and delivered straight to the liver where they can be used directly for energy production (instead of being stored as fat).


In essence, they act similar to carbohydrates, but without the requirement of insulin and with no effect on blood sugar.
Studies have demonstrated that Medium Chain Triglycerides oil consumption along with a healthy diet can help to maintain a healthy body weight while sparing lean tissue.
The following grades are available based on the percentage of C8 in the Medium Chain Triglycerides: – 99% C8; 98% C8; 95% C8; 70% C8; 60% C8 – the balance percentage being C10.


Medium Chain Triglycerides oil is produced in a process called fractionation that extracts the caprylic and capric acid from the other fats in the coconut or palm oil.
Once these Medium Chain Triglycerides are isolated, a chemical process called lipase esterification is used to produce triglycerides using the enzyme lipase.
Next, the lipase is filtered out, and the oil goes through deacidification, bleaching and deodorizing.


After a quality analysis, the final product of Medium Chain Triglycerides oil is ready for consumption.
Despite being produced in a lab, Medium Chain Triglycerides oil contains entirely natural fats.
Medium-chain triglycerides (MCTs) are fats with an unusual chemical structure that allows the body to digest them easily.
Most fats are broken down in the intestine and remade into a special form that can be transported in the blood.


But Medium Chain Triglycerides are absorbed intact and taken to the liver, where they are used directly for energy.
In this sense, Medium Chain Triglycerides are processed very similarly to carbohydrates.
Medium Chain Triglycerides are different enough from other fats that they can be used as fat substitutes by people (especially those with AIDS) who need calories but are unable to absorb or metabolize normal fats.


Medium Chain Triglycerides have also shown a bit of promise for improving body composition and enhancing athletic performance.
There is no dietary requirement for Medium Chain Triglycerides.
Coconut oil, palm oil, and butter contain up to 15% Medium Chain Triglycerides (plus a lot of other fats).
You can also buy Medium Chain Triglycerides as purified supplements.


Most Medium Chain Triglycerides oil contains caprylic acid (C8), capric acid (C10) or a combination of both.
Typically the proportion of Medium Chain Triglycerides in MCT oil is 50 to 80 percent caprylic acid and 20 to 50 percent capric acid.
Caproic acid (C6) is often removed from Medium Chain Triglycerides oil because it can have an unpleasant taste and smell.
Medium Chain Triglycerides oil typically does not contain lauric acid (C12) either because its benefits are debated.


Because lauric acid contains 12 carbons, it is on the cusp of being a long-chain triglyceride.
Some argue that lauric acid may act the same as an LCT in the body and be more difficult to absorb and process.
Caprylic and capric acid are valuable for MCT oil because they can be more rapidly absorbed and processed in the body than other fatty acids.
Some studies have, however, found that use of Medium Chain Triglycerides might produce improvements in body composition (ratio of fat to lean tissue).


A related supplement called structured medium- and long-chain triacylglycerols (SMLCT) has been created to provide the same potential benefits as Medium Chain Triglycerides , but in a form that can be used as cooking oil.
Medium Chain Triglycerides are fats found in foods like coconut oil.
Medium Chain Triglycerides’re metabolized differently than the long-chain triglycerides (LCT) found in most other foods.
Medium Chain Triglycerides oil is a supplement that contains a lot of these fats and is claimed to have many health benefits.


Triglyceride is simply the technical term for fat.
Triglycerides have two main purposes.
They’re either burned for energy or stored as body fat.
Triglycerides are named after their chemical structure, specifically the length of their fatty acid chains.


All triglycerides consist of a glycerol molecule and three fatty acids.
The majority of fat in your diet is made up of long-chain fatty acids, which contain 13–21 carbons.
Short-chain fatty acids have fewer than 6 carbon atoms.
In contrast, the medium-chain fatty acids in Medium Chain Triglycerides have 6–12 carbon atoms.


The following are the main medium-chain fatty acids:
C6: caproic acid or hexanoic acid
C8: caprylic acid or octanoic acid
C10: capric acid or decanoic acid
C12: lauric acid or dodecanoic acid


Some experts argue that C6, C8, and C10, which are referred to as the “capra fatty acids,” reflect the definition of Medium Chain Triglycerides more accurately than C12 (lauric acid).
Medium Chain Triglycerides are a useful fat substitute for those who have difficulty digesting fat.
This makes Medium Chain Triglycerides potentially helpful for people with AIDS, who need to find a way to gain weight but cannot digest fat easily.


Medium Chain Triglycerides might theoretically be helpful for those who have trouble digesting fatty foods because they lack the proper enzymes (pancreatic insufficiency), but taking digestive enzymes appears to be more effective.
Although this may sound paradoxical given the above, some evidence suggests that Medium Chain Triglycerides consumption might also enhance the body's natural tendency to burn fat.



USES and APPLICATIONS of MEDIUM CHAIN TRIGLYCERIDES:
Due to their ability to be absorbed rapidly by the body, Medium Chain Triglycerides have found use in the treatment of a variety of malabsorption ailments.
Medium Chain Triglycerides supplementation with a low-fat diet has been described as the cornerstone of treatment for Waldmann disease.
Studies have also shown promising results for epilepsy through the use of ketogenic dieting.


People use Medium Chain Triglycerides for involuntary weight loss called cachexia or wasting syndrome.
Medium Chain Triglycerides are also used for obesity, seizures, athletic performance, Alzheimer disease.
Since the Medium Chain Triglycerides are digested quicker than the LCT, it gets to be used as energy first.
Medium Chain Triglycerides are used in parenteral nutrition therapy: they serve as a source of calories and essential fatty acids in conditions associated with malnutrition and malabsorption.


Medium Chain Triglyceridesare also available as over-the-counter natural products and health supplements.
Medium-chain triglycerides have played a role in the food and beverage industry for several years, but their use has skyrocketed in the last decade as more consumers are seeking whole foods and healthy fats for nutrition and weight loss.
Medium Chain Triglycerides are used as a source of fat in semi-elemental feeds for patients who have digestive issues or problems breaking down the more structurally complicated nutrients that we find in regular diets.


Medium Chain Triglycerides are also better tolerated in those diagnosed with inflammatory bowel disorders like Crohn’s and colitis and post gallbladder removal.
Athletes, especially long-distance runners and cyclists, often prefer to supplement with Medium Chain Triglycerides, including them as a significant contribution to calorie intake, especially in the run-up to an event.


Often these athletes may even prioritize their intake of Medium Chain Triglycerides over additional carbs, as MCTs provide an equally efficient source of energy, but in a more concentrated form; i.e. you need less for a similar amount of energy (carbs provide 4 kcal per gram).
Medium Chain Triglycerides oil can also be used as a substitute for conventional oils in salad dressings, sauces, or cooking.
Medium Chain Triglycerides can be eaten as salad oil or used in cooking.


When taken as an athletic supplement, dosages around 85 mg daily are common.
Athletes often sip carbohydrate-loaded drinks during exercise.
Medium Chain Triglycerides may provide an alternative.
Like other fats, they provide more energy per ounce than carbohydrates; but unlike normal fats, this energy can be released rapidly.


Medium Chain Triglycerides work much like a carbohydrate in that they’re a readily available energy source but unlike carbs, MCTs can also aid in fat loss and lean muscle growth.
Medium Chain Triglycerides are a popular supplement for those opting for higher fat diets such as keto.
The different clinical applications of Medium Chain Triglycerides include liver and gallbladder disease, pancreatic enzyme insufficiency, pancreatitis, chylothorax, intestinal lymphangiectasia and type 1 hyperlipidemia.


All require the manipulation of dietary fat for successful dietetic management.
Medium Chain Triglycerides are used along with usual medications for treating food absorption disorders including diarrhea, steatorrhea (fat indigestion), celiac disease, liver disease, and digestion problems due to partial surgical removal of the stomach (gastrectomy) or the intestine (short bowel syndrome).
Usual dietary fats, by comparison, are long-chain triglycerides.


People use Medium Chain Triglycerides as medicine.
Medium Chain Triglyceridesare also used for “milky urine” (chyluria) and a rare lung condition called chylothorax.
Other uses of Medium Chain Triglycerides include treatment of gallbladder disease, AIDS, cystic fibrosis, Alzheimer's disease, and seizures in children.


Athletes sometimes use Medium Chain Triglycerides for nutritional support during training, as well as for decreasing body fat and increasing lean muscle mass.
Medium Chain Triglycerides are sometimes used as a source of fat in total parenteral nutrition (TPN).
In TPN, all food is delivered intravenously (by IV).
This type of feeding is necessary in people whose gastrointestinal (GI) tract is no longer working.


Intravenous Medium Chain Triglycerides are also given to prevent muscle breakdown in critically ill patients.
Medium chain triglycerides may be mixed with fruit juice, used on salad or vegetables, used in cooking or baking, or otherwise blended in with sauces or other foods.
Medium chain triglycerides is for dietary use in people whose bodies cannot digest certain foods properly.


This includes people who are gluten or lactose intolerant, or who have unintended weight loss or need increased calories for other medical reasons.
Medium Chain Triglycerides are medium-chain (6 to 12 carbons) fatty acid esters of glycerol most frequently used in nutraceutical foods and beverages, as well as cosmeceutical personal care products.


Medium Chain Triglycerides are often used as high-quality carriers and emollients in the formulation of cosmetics to be certified according to the Natural and Organic Ecocert Standards and regularly used in flavorings and fragrances due to their bland taste and low natural odor.
In the human body, Medium Chain Triglycerides passively diffuse from the GI tract into the portal vein without the modification that long-chain fatty acids or very-long-chain fatty acids require.


Since Medium Chain Triglycerides are bland compared to other fats and do not generate flavor or fragrance off-notes, they are used in personal care products and pharmaceuticals.
In food, beverage and nutraceutical applications, Medium Chain Triglycerides ingredients rapidly absorb into the body and serve as potentially good energy sources for daily exercise enthusiasts, athletes and bodybuilders.
Medium Chain Triglycerides are often incorporated into beverages, mixes, nutritional bars or energy foods.


-Fat malabsorption:
A double-blind, placebo-controlled study on 24 men and women with AIDS suggests that Medium Chain Triglycerides can help improve AIDS-related fat malabsorption.
In this disorder, fat is not digested; it passes unchanged through the intestines, and the body is deprived of calories as well as fat-soluble vitamins.


-Uses of Medium Chain Triglycerides:
*Food Additive
*Phamaceutical
*massage oil
*perfume carrier
*general carrier oil
*light weight moisturizer for all skin types
*Also known as Fractionated Coconut Oil


-Technical uses of Medium Chain Triglycerides:
Medium Chain Triglycerides are bland compared to other fats and do not generate off-notes (dissonant tastes) as quickly as LCTs.
Medium Chain Triglycerides are also more polar than LCTs.
Because of these attributes, Medium Chain Triglycerides are widely used as carrier oils or solvents for flavours and oral medicines and vitamins.


-Applications of Medium Chain Triglycerides in Foods:
In the 1950s, the production of processed fats and oils from coconut oil was popular in the United States.
It became necessary to find uses for the medium-chain fatty acids (MCFAs) that were byproducts of the process, and a production method for Medium Chain Triglycerides was established.
At the time of this development, its use as a non-fattening fat was being studied.
In the early days MCFAs included fatty acids ranging from hexanoic acid (C6:0) to dodecanoic acid (C12:0), but today their compositions vary among manufacturers and there seems to be no clear definition.
MCFAs are more polar than long-chain fatty acids (LCFAs) because of their shorter chain length, and their hydrolysis and absorption properties differ greatly.


-Pharma relevance:
Medium Chain Triglycerides can be used in solutions, liquid suspensions and lipid-based drug delivery systems for emulsions, self-emulsifying drug delivery systems, creams, ointments, gels and foams as well as suppositories.
Medium Chain Triglyceridesare also suitable for use as solvent and liquid oily lubricant in soft gels.
Brand names of pharma-grade MCT include Kollisolv MCT 70.


-Medical relevance:
Medium Chain Triglycerides passively diffuse from the GI tract to the portal system (longer fatty acids are absorbed into the lymphatic system) without requirement for modification like long-chain fatty acids or very-long-chain fatty acids.
In addition, Medium Chain Triglycerides do not require bile salts for digestion.
Patients who have malnutrition, malabsorption or particular fatty-acid metabolism disorders are treated with Medium Chain Triglycerides because MCTs do not require energy for absorption, use, or storage.


-Increases exercise performance:
Because they can increase energy levels and burn fat, Medium Chain Triglycerides can boost exercise performance for athletes and bodybuilders.
Consuming Medium Chain Triglycerides oil before exercise can lead to better workouts.
Medium Chain Triglycerides can also increase lean muscle mass while decreasing body fat.


-Improves gut health and digestion:
Medium Chain Triglycerides improve gut health by killing harmful bacteria without impacting good bacteria in the gut.
Medium Chain Triglycerides can prevent diarrhea and fat indigestion.
Medium Chain Triglycerides can also aid in restoring proper digestive functions for those who have experienced a gastrectomy.


-Improves cognitive health:
Consuming Medium Chain Triglycerides may lead to better focus and more clear thinking.
Because the brain is composed of fatty acids, improved gut health has a positive impact on brain functioning.
The ketones produced by Medium Chain Triglycerides are also able to fuel the central nervous system better than LCTs because they can pass through the blood-brain barrier.
Medium Chain Triglycerides may also be able to slow the effects of dementia in those with Alzheimer’s disease by providing ketones to the brain.


-Lowers risk of diabetes:
Medium Chain Triglycerides may be beneficial for those who have diabetes as they can lower blood sugar levels and increase insulin sensitivity.
Better insulin sensitivity is also an important factor in the prevention of diabetes in those who are at high risk.
Consuming Medium Chain Triglycerides can also help reduce body weight which is another risk factor for diabetes.


-Pharmacokinetics uses of Medium Chain Triglycerides:
Medium Chain Triglycerides have a different pattern of absorption and utilization than long chain triglycerides (LCTs) that make up 97 percent of dietary fats.
For absorption of LCTs to occur, the fatty acid chains must be
separated from the glycerol backbone by the lipase enzyme.
These fatty acids form micelles, are then absorbed and reattached to glycerol, and the resultant triglycerides travel through the lymphatics en route to the bloodstream.
Up to 30 percent of Medium Chain Triglycerides are absorbed intact across the intestinal barrier and directly enter the portal vein.
This allows for much quicker absorption and utilization of Medium Chain Triglycerides compared to LCTs.
Medium Chain Triglycerides are transported into the mitochondria independent of the carnitine shuttle, which is necessary for
LCT-mitochondrial absorption. Oxidation of Medium Chain Triglycerides provides 8.3 calories per gram.



MEDIUM CHAIN TRIGLYCERIDES OILS IN BEAUTY PRODUCTS:
Medium Chain Triglycerides oil is a relatively new player in the beauty and personal care sectors but is poised to become a valuable addition.
Following the popularity of coconut oil in skin care, moisturizers and other beauty products, Medium Chain Triglycerides can offer many of the same benefits.
Medium Chain Triglycerides oil is great for adding moisture to the skin or lips and can be incorporated in lotions, moisturizers or creams.
Medium Chain Triglycerides oil is lightweight and does not leave skin feeling oily or greasy when used as a moisturizer.



TYPES OF MEDIUM CHAIN TRIGLYCERIDES:
There are a few types of Medium Chain Triglycerides, consisting of different numbers of carbon atoms:
C6: caproic acid
C8: caprylic acid
C10: capric acid
C12: lauric acid
The number of carbon atoms in a triglyceride determines how the body processes them for energy.
In general, the longer the chain, the harder for the body to process into ATP—[which is] the energy currency of the cells in our bodies.
Since Medium Chain Triglycerides are shorter, they are the preferred energy sources when using fat for energy.
The body also utilizes short-chain triglycerides (or short-chain fatty acids) for energy, which are derived from the fermentation of dietary fibers and undigested sugars by bacteria in the gut.



WHAT ELSE IS MEDIUM CHAIN TRIGLYCERIDES KNOWN AS?
Note that Medium-chain Triglycerides is also known as:
MCTs
MCT oil
medium-chain fatty acids
Medium-chain Triglycerides should not be confused with:
coconut oil



SOME FOODS THAT ARE RICH IN MEDIUM CHAIN TRIGLYCERIDES:
*Coconut oil:
As the primary source for Medium Chain Triglycerides oil, more than 60 percent of the fatty acids in coconut oil are Medium Chain Triglycerides.
While coconut oil contains a higher concentration of lauric acid, it still has the highest percentage of caprylic and capric acid making up 13 percent of its fatty acids.

*Palm kernel oil:
Another rich source of Medium Chain Triglycerides, the fatty acids in palm kernel oil are over 50 percent Medium Chain Triglycerides with about 7 percent being caprylic and capric acid.

*Coconut meat and cream:
Coconut meat and cream also rank high as Medium Chain Triglycerides-rich whole foods and contain a good percentage of caprylic and capric acid, at eight and four percent respectively.

*Dairy products:
Butter, goat cheese and feta cheese are all great natural sources of Medium Chain Triglycerides, with percentages ranging from four to eight percent of their fatty acids.
Other cheeses, creams and milk contain Medium Chain Triglycerides as well but in smaller proportions.

While whole foods are a great way to naturally introduce more Medium Chain Triglycerides into your diet, they still contain a relatively low percentage of Medium Chain Triglycerides compared to MCT oil.
Whole foods with Medium Chain Triglycerides also contain lauric acid and LCTs that some consumers seek to avoid and which can slow down the rapid metabolizing of MCT for energy.
Supplementing with Medium Chain Triglycerides oil can allow consumers to avoid lauric acid and other fatty acids while reaping the benefits of caprylic and capric acids.
MCT oil contains 100 percent caprylic and capric acid, meaning consumers do not need to ingest as high of a quantity to receive the same benefits as they would with coconut oil, palm kernel oil or other whole food medium-chain triglyceride sources.



SOURCES OF MEDIUM CHAIN TRIGLYCERIDES:
There are two main ways to increase your intake of Medium Chain Triglycerides — through whole food sources or supplements like MCT oil.



MEDIUM CHAIN TRIGLYCERIDES IN FOODS:
Medium Chain Triglycerides are not that common in foods, but are found in small amounts in dairy fats like butter (about 8.3g per 100g) and some types of cheese.



BENEFITS OF INGESTING MEDIUM CHAIN TRIGLYCERIDES:
Besides the aforementioned ease with which they are metabolized for energy, Medium Chain Triglycerides are beneficial because they may aid in weight loss.
This is due to their ability to help the body burn fat and to experience a sensation of fullness.
Medium Chain Triglycerides are lower themselves in calories per gram when compared to long-chain triglycerides.
Medium Chain Triglycerides may help the body reach ketosis, a metabolic state in which fuel comes principally from fat.
As fuel sources go, ketones are considered preferable over glucose, especially if the area being fueled is the brain.
In addition, Medium Chain Triglycerides have antimicrobial properties and may help promote a healthy gut in which good bacteria are more likely to thrive.
Medium Chain Triglycerides Oil Makes Consuming These Beneficial Fats Easy.
Medium-chain triglycerides can be obtained by eating foods that naturally contain them.
Coconuts and dairy products are examples of these, but it’s not always easy or practical to consume them on a regular basis and in the necessary quantities.



BENEFITS OF MEDIUM CHAIN TRIGLYCERIDES:
Medium-chain triglycerides (MCTs) are types of fat which have shown to provide benefits to health and performance.
Triglycerides are the main constituents of fats, and each triglyceride is made up of three fatty acids with a backbone of glycerol.
The majority of fats found in our food are long-chain triglycerides (LCTs).
Medium Chain Triglycerides are triglycerides in which the fatty acids in their structure are 6 to 12 carbon atoms in length.
There are four main fatty acids that make up Medium Chain Triglycerides – known as medium-chain fatty acids (MCFAs) – and the number denotes their chain length:
C6:0 Caproic acid
C8:0 Caprylic acid
C10:0 Capric acid
C12:0 Lauric acid



HEALTH BENEFITS OF MEDIUM CHAIN TRIGLYCERIDES:
Because Medium Chain Triglycerides are so easily absorbed, they have been used clinically since the 1950s in cases of pancreatic insufficiency, fat malabsorption and in total parenteral nutrition.
Later Medium Chain Triglycerides were added to preterm infant formulas.
More recently, Medium Chain Triglycerides have drawn the attention of athletes and those looking to enhance their production of ketones.
Including Medium Chain Triglycerides in the diet may support the following health goals.
Medium chain triglycerides (MCTs) are a class of lipids in which three saturated fats are bound to a glycerol backbone.
What distinguishes Medium Chain Triglycerides from other triglycerides is the fact that each fat molecule is between six and twelve carbons in length.
Medium Chain Triglycerides are a component of many foods, with coconut and palm oils being the dietary sources with the highest concentration of Medium Chain Triglycerides.
Medium Chain Triglycerides are also available as a dietary supplement.



HEALTH BENEFITS OF MEDIUM CHAIN TRIGLYCERIDES AND MEDIUM CHAIN TRIGLYCERIDES OIL:
Medium Chain Triglycerides and Medium Chain Triglycerides oil have gained popularity as a health food and dietary supplement because of the numerous benefits they offer.
In addition to providing quick and efficient energy, Medium Chain Triglycerides oil can aid in weight loss, improve brain functioning and provide treatment for digestive diseases.
Here are a few of the main health benefits of Medium Chain Triglycerides and Medium Chain Triglycerides oil:
Maintains healthy weight loss and management:
*Medium Chain Triglycerides and Medium Chain Triglycerides oil have a variety of properties that aid in weight loss and management.
*Compared to LCTs, Medium Chain Triglycerides have fewer calories but can better increase the feeling of fullness and reduce appetite.
*Medium Chain Triglycerides are also burned more rapidly by the body and are less likely to be stored as fat.
*Some studies have shown that Medium Chain Triglycerides may even increase the body’s ability to burn fat, to reduce accumulation of body fat and help prevent obesity.
*Medium Chain Triglycerides can be particularly beneficial for those on a ketogenic diet, as they produce ketones that allow a person to consume more carbs while maintaining a state of ketosis.



WHAT IS MEDIUM CHAIN TRIGLYCERIDES OIL?
In nutrition, not all fats are created equal.
Healthier fats are typically considered monounsaturated and polyunsaturated fats.
For example, omega-3 fatty acids, like EPA and DHA, are a type of polyunsaturated fat that plays an important role in regulating inflammation in the body.
Healthy fat sources include wild-caught salmon and sardines, avocado, walnuts, almonds, ground chia and flax seeds, flax seed oil, olive oil and avocado oil.
Less healthy fats include saturated fats and trans fats.

While Medium Chain Triglycerides oil is a manufactured source of saturated fat—usually derived from coconut or palm oils—it differs from other fat sources.
Most fatty acids are long-chain, meaning they contain 13 to 21 carbon atoms, while short-chain fatty acids contain fewer than six carbon atoms.
Medium-chain fatty acids like those found in MCT, however, contain six to 12 carbon atoms.
It’s worth noting, however, current dietary guidelines recommend limiting saturated fat to no more than 10% of maximum daily total calories, and specifically highlight coconut oil, palm kernel oil and palm oil as high sources of saturated fat.



WHAT ARE THE SOURCES OF MEDIUM CHAIN TRIGLYCERIDES OIL?
MCT oil is most often made from coconut or palm kernel oil, and is produced by extracting pure Medium Chain Triglycerides from the whole food.
Coconut oil is the primary source for Medium Chain Triglycerides oil, but palm kernel oil is also very common, making up nearly 34 percent of MCT oil production.
Consumers sometimes confuse Medium Chain Triglycerides oil and coconut oil as being the same product, but coconut oil contains all four types of Medium Chain Triglycerides as well as other fats.
MCT oil, on the other hand, contains only specific Medium Chain Triglycerides and no other kinds of fats.



POSSIBLE HEALTH BENEFITS OF MEDIUM CHAIN TRIGLYCERIDES OIL
-Weight loss:
Feeling full is a good way to stop the snacking and extra eating that can lead to extra pounds — and Medium Chain Triglycerides oil may be able to help in that regard.
Researchers found that Medium Chain Triglycerides oil may promote the release of hormones that signal your belly is at capacity, which can reduce appetite.
The study connected the usage of Medium Chain Triglycerides oil with lower overall food intake.
Another study suggested that Medium Chain Triglycerides oil could promote a small amount of weight loss, though it noted more research is needed to gauge its potential.
-A quick energy boost:
As an easily digested form of fat, Medium Chain Triglycerides oil can provide a quick burst of energy after being consumed.
(The properties of MCT oil allow it to bypass some of your body’s normal absorption process.)
-Improved athletic performance:
Medium Chain Triglycerides oil is a proven performance enhancer.



HOW MANUFACTURERS AND CONSUMERS USE MEDIUM CHAIN TRIGLYCERIDES OIL:
Medium Chain Triglycerides oil is quickly growing in popularity as a dietary supplement, and many consumers and manufacturers are using MCT oil as a food additive for health foods and beverages.
Its ability to boost energy and performance makes Medium Chain Triglycerides oil a popular additive for energy bars, drinks and powdered protein shakes.
Because it is colorless and tasteless, Medium Chain Triglycerides oil can be consumed plain or added to a wide variety of products without altering their flavor.
Many consumers incorporate Medium Chain Triglycerides oil into homemade recipes as well for additional health benefits.
Below are some popular ways to consume Medium Chain Triglycerides oil:

*Medium Chain Triglycerides coffee:
Blending coconut oil or Medium Chain Triglycerides oil into coffee is one of the most popular uses for MCT oil.
This MCT-charged coffee provides a boost of energy and helps stimulate the brain at the start of the day.

*Smoothies:
Adding Medium Chain Triglycerides oil to post or pre-workout shakes or smoothies provides more energy for exercising and helps aid in recovery after high-intensity workouts.

*Salad dressings or marinades:
Medium Chain Triglycerides oil can add smoothness to salad dressing or marinade, without altering the flavor.

*Sauces:
Because Medium Chain Triglycerides oil has a very low smoke point, it can only be used for cooking at low temperatures.
This makes it a perfect addition to sauces that can simmer without reducing the effectiveness of the Medium Chain Triglycerides.

*Homemade energy bars:
Medium Chain Triglycerides oil can be used to make delicious and healthy energy balls or bars when blended with dried fruit, nut butter, coconut or cacao powder.



FOOD SOURCES OF MEDIUM CHAIN TRIGLYCERIDES:
The following foods are the richest sources of medium-chain triglycerides, including lauric acid, and listed along with their percentage composition of Medium Chain Triglycerides:
coconut oil: 55%
palm kernel oil: 54%
whole milk: 9%
butter: 8%
Although the sources above are rich in Medium Chain Triglycerides, their composition of them varies.

For example, coconut oil contains all four types of MCTs, plus a small amount of LCTs.
However, its Medium Chain Triglycerides consist of greater amounts of lauric acid (C12) and smaller amounts of the capra fatty acids (C6, C8, and C10).
In fact, coconut oil is about 42% lauric acid, making it one of the best natural sources of this fatty acid.
Compared with coconut oil, dairy sources tend to have a higher proportion of capra fatty acids and a lower proportion of lauric acid.
In milk, capra fatty acids make up 4–12% of all fatty acids, and lauric acid (C12) makes up 2–5%



WHAT FOODS CONTAIN MEDIUM CHAIN TRIGLYCERIDES?
Medium Chain Triglycerides are found primarily in coconut oil, palm kernel oil, coconut products, and dairy products.
Palm kernel oil, coconut oil and other coconut products contain higher concentrations of lauric acid and lower concentrations of caprylic and capric acid.



HOW MEDIUM CHAIN TRIGLYCERIDES WORKS:
Medium Chain Triglycerides has many different clinical applications which relate to it being a useful source of energy when LCT needs to be restricted.
Due to having a shorter chain length, Medium Chain Triglycerides is digested and transported differently to LCT: it does not require bile acids/salts to emulsify it; it is more easily hydrolysed than LCT; it is absorbed directly into the portal venous circulation.
Medium Chain Triglycerides does not need to be packaged into chylomicrons and therefore does not use the lymphatic system for transportation unlike LCT.



METABOLISM OF MEDIUM CHAIN TRIGLYCERIDES:
Medium chain triglycerides are hydrolyzed by lipoprotein lipase to glycerol and medium-chain free fatty acids such as alpha-linolenic acid and linoleic acid.
Free fatty acids then undergo β-oxidation in the organs such as the liver, kidneys, and heart.
Alpha-linolenic acid and linoleic acid are metabolized within a common biochemical pathway through a series of desaturation and elongation steps.
Downstream products of alpha-linolenic acid are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and linoleic acid is converted to arachidonic acid.



ABSORPTION OF MEDIUM CHAIN TRIGLYCERIDES:
Medium Chain Triglycerides are rapidly absorbed.
Medium Chain Triglycerides passively and directly diffuse across the gastrointestinal tract into the portal system then to liver, where they are oxidized.



DIGESTION, ABSORPTION, AND METABOLISM OF MEDIUM CHAIN TRIGLYCERIDES:
As well as being structurally different from LCTs, Medium Chain Triglycerides are absorbed and metabolized in a different way and are treated more like an energy-dense carbohydrate source than a fat.
Indeed, they are slightly less energy-dense than LCTs in that they provide approximately 8.3 kcal per gram compared to 9.0 kcal per gram.

After digestion, Medium Chain Triglycerides are absorbed differently to other fats in that they passively cross the small intestine wall.
LCTs, on the other hand, are absorbed into the lymphatic system.
Also, Medium Chain Triglycerides do not require bile salts for digestion, so humans find MCTs easier to digest and metabolize.
The rate at which Medium Chain Triglycerides are absorbed is similar to that of glucose and faster than that of LCTs.



VOLUME OF DISTRIBUTION:
The apparent volumes of distribution have been researched as approximately 4.5 L for Medium Chain Triglycerides and 19 L for medium chain fatty acids in a typical 70-kg subject



MECHANISM OF ACTION OF MEDIUM CHAIN TRIGLYCERIDES:
Medium-chain triglycerides (MCTs) are broken down into glycerol and medium-chain fatty acids, which are directly absorbed into the blood stream and transported to the target organs, where they undergo β-oxidation to form acetyl-CoA.
The β-oxidation is the most common mechanism of action for energy production derived from fatty acid metabolism.
Because medium-chain fatty acids are rapidly oxidized, it leads to greater energy expenditure.
Fatty acids are important substrates for energy production and also play a critical role in membrane structure and function.
Additionally, fatty acids act as precursors for bioactive molecules (such as prostaglandins) and as regulators of gene expression.
Fatty acids may mediate their effects on energy expenditure, food consumption, and fat deposition by upregulating the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism via activating Akt and AMPK signaling pathways and inhibiting the TGF-β signaling pathway.
It is proposed that the promotion of weight loss by Medium Chain Triglycerides may be due to sympathetic activation of brown fat thermogenesis.



PHARMACODYNAMICS:
Medium-chain triglycerides (MCTs) contained in injectable lipid emulsions serve as a source of calories and essential fatty acids, which are important substrate for energy production.
It is proposed that Medium Chain Triglycerides induces weight loss through increasing energy expenditure and fat oxidation, and altering body composition.
However, it is unknown whether the effects of Medium Chain Triglycerides on energy expenditure and body weight are long-lasting and sustainable.
Medium Chain Triglycerides can also play a role in food intake and satiety, as some studies showed that MCT consumption led to reduced food intake.
While Medium Chain Triglycerides was shown to reduce energy intake, it was not shown to affect appetite.
Medium Chain Triglycerides may facilitate the absorption of calcium.



WHAT IS MEDIUM CHAIN TRIGLYCERIDES OIL?
Medium Chain Triglycerides are fats which the body can burn for fuel.
Medium Chain Triglycerides’re found in foods and are desirable because they’re metabolized more efficiently than their long-chain counterparts and are thus less likely to be stored as fat.
Medium Chain Triglycerides oil contains these triglycerides in concentrated form.

It’s a man-made product, created when Medium Chain Triglycerides are extracted and isolated from coconut oil or palm kernel oil, the two richest sources of these fatty acids.
Medium Chain Triglycerides oil is a highly concentrated source of medium-chain triglycerides.
It’s man-made via a process called fractionation.
This involves extracting and isolating the Medium Chain Triglycerides from coconut or palm kernel oil.
Medium Chain Triglycerides oils generally contain either 100% caprylic acid (C8), 100% capric acid (C10), or a combination of the two.

Caproic acid (C6) is not normally included due to its unpleasant taste and smell.
Meanwhile, lauric acid (C12) is often missing or present in only small amounts (9Trusted Source).
Given that lauric acid is the main component in coconut oil, be careful of manufacturers who market Medium Chain Triglycerides oils as “liquid coconut oil,” which is misleading.
Many advocates market Medium Chain Triglycerides oil as better than coconut oil because caprylic acid (C8) and capric acid (C10) are thought to be more rapidly absorbed and processed for energy, compared with lauric acid (C12)



MEDIUM CHAIN TRIGLYCERIDES FOR PHARMACEUTICAL APPLICATIONS:
Medium Chain Triglycerides are found mainly in palm seed oil and coconut oil.
Medium Chain Triglycerides are obtained from these oils using special methods and then esterified into new triglycerides (fat molecules).
Medium Chain Triglycerides have a broad range of applications.
Medium Chain Triglycerides can be used in different galenic forms, e.g. as a substrate or lubricant in tablets, soft gel capsules and dragées, or as a solubilizer, emulsifier and suppository base.



THERE ARE A FEW MAIN TYPES OF MEDIUM CHAIN FATTY ACIDS THAT ARE DEFINED BY THE LENGTH OF THEIR ALIPHATIC TAIL:
*Caproic acid or hexanoic acid (C6):
As the shortest Medium Chain Triglycerides with six carbons in its aliphatic tail, caproic acid metabolizes very quickly.
Because it can have an unpleasant taste or smell, caproic acid is typically removed during the manufacturing of Medium Chain Triglycerides oil.
*Caprylic acid or octanoic acid (C8):
Because of its anti-microbial properties, caprylic acid is effective for maintaining a healthy gut.
Caprylic acid is the second most efficient Medium Chain Triglycerides after caproic acid but does not have an offensive taste or smell.
For this reason, caprylic acid is often the primary Medium Chain Triglycerides used in MCT oil.
*Capric acid or decanoic acid (C10):
While capric acid metabolizes a bit slower than caprylic acid, it still turns into ketones very quickly in the liver.
Capric is the other most common Medium Chain Triglycerides used for MCT oil.
*Lauric acid or dodecanoic acid (C12):
Lauric acid makes up most of the Medium Chain Triglycerides in coconut oil, however, it is often removed from MCT oil.
Compared to other Medium Chain Triglycerides, lauric acid is the slowest to metabolize but still provides anti-microbial properties and other health benefits.



PHYSICAL and CHEMICAL PROPERTIES of MEDIUM CHAIN TRIGLYCERIDES:
Appearance (physical state, color, etc.): Colourless liquid
Melting point: < -5°C
Boiling point: Approx 230°C @ 760 mmHg
Flash point: > 230°C (Cleveland open cup)
Density: Approx 0.93-0.96 g/ml at 20 °C
Particle Size Distribution: Not applicable
Vapor Pressure: 3 mbar @ 20 °C
Partition coefficient : n-octanol/water: Not available
Water Solubility: Insoluble @ 20 °C
Surface Tension: Not available
Auto Flammability: Not available
Flammability: Not available
Explosiveness: Not available
Oxidizing Properties: Not available
Stability in organic solvent: Not available

Dissociation constant: Not available
Viscosity: 30 – 32 mPa.s @ 20 °C
Acid Value: mg KOH/g 0.1 Max
Sap. Value: mg KOH/g 325 – 345
OHV: mg KOH/g 10 Max
Color: APHA 50 Max
Moisture: % 0.1 Max
ASH Content: % 0.1 Max
PV Meq/Kg: 1 Max
Viscosity: mPa.s 20°C 25 – 33
Density: g/cm3 20°C 0.930 – 0.960
Refrective Index: 20°C 1.448 – 1.451
Fatty Acid Composition:
C6 % 0.5 Max
C8 % 53 Min
C10 % 36 – 47
C12 % 1.5 Max



FIRST AID MEASURES of MEDIUM CHAIN TRIGLYCERIDES:
-Eye contact:
Immediately flood the eye with plenty of water for at least 15 minutes, holding the eye open.
-Skin contact:
Wash skin thoroughly with soap and water.
Remove contaminated clothing as washing proceeds.
-Inhalation:
Keep warm and at rest.
-Ingestion:
Wash out mouth with water.
Keep warm and at rest.
-Most important acute and delayed symptoms/effects:
None



ACCIDENTAL RELEASE MEASURES of MEDIUM CHAIN TRIGLYCERIDES:
-Measures required for personal protection and protective equipment:
Use rubber gloves, air respirator, goggles, safety shoes and lab coat.
Remove contaminated clothing and wash hands between breaks and at end of duty hours.
Locate eye washes and emergency showers in all work and storage areas.
-Measures required for environment protection:
Not available
-Clean-up and removal method:
Cover with an inert or noncombustible inorganic absorbent material, sweep up and remove to an approved disposal container.
Clean with hot water & detergents.



FIRE FIGHTING MEASURES of MEDIUM CHAIN TRIGLYCERIDES:
-Suitable (and unsuitable) extinguishing media:
Use dry powder, water spray, foam, carbon dioxide for extinguishing.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MEDIUM CHAIN TRIGLYCERIDES:
-Exposure limits of the chemical substance, biological exposure limits and etc.:
None established.
-Appropriate engineering controls:
Use normal precautionary measures for handling chemicals.
-Personal protective equipment:
● Protection of respiratory system : Wear air respirator
● Eye protection : Wear goggles
● Hand protection : Wear protective gloves
● Body protection : Wear protective clothing, safety shoes
● Hand protection : Wear protective gloves
● Body protection : Wear protective clothing, safety shoes



HANDLING and STORAGE of MEDIUM CHAIN TRIGLYCERIDES:
-Precautions for safe handling:
Wear personal protective equipment.
-Conditions for safe storage (including incompatibilities):
Store in tightly closed original container when not in use.
Storage area should be cool and dry.



STABILITY and REACTIVITY of MEDIUM CHAIN TRIGLYCERIDES:
-Chemical stability :
Not available.
-Possibility of hazardous reactions :
Not available
-Hazardous decomposition products :
None known



SYNONYMS:
Caprylic/capric triglyceride
Coconut oil, fractioned
Fractionated coconut oil
Fractionated triglyceride of coconut oil
Medium chain triglyceride
Medium-chain glycerides
1,2,3-Propanetriol Trioctanoate
AC-1202
Acide Caprique
Acide Caproïque
Acide Caprylique
Acide Laurique
Capric Acid
Caproic Acid
Caprylic Acid
Caprylic Triglycerides
Lauric Acid
MCT
MCT's
MCTs
Medium-Chain Triacylglycerols
Medium-Chain Triglycerides
TCM
Tricaprylin
Triglycérides Capryliques
Triglicéridos de Cadena Media (TCMs)
Trioctanoin
MEDIUM-CHAIN TRIGLYCERIDES (MCT)
Medium-chain triglycerides (MCT) is a useful cosmetic agents as emollients, masking agent, perfuming agent, skin conditioning and solvents.
As a fully saturated emollient tri-ester, Medium-chain triglycerides (MCT) is recommended as an alternative for mineral or vegetable oils in a wide variety of personal care and pharmaceutical applicatxions.
As a fully saturated triglyceride, Medium-chain triglycerides (MCT) is light emollient with good lubricity.

CAS: 65381-09-1
MF: C21H44O7
MW: 408.58
EINECS: 265-724-3

Medium-chain triglycerides (MCT) is a liquid glycol ether with chemical stability.
Medium-chain triglycerides (MCT) is used in the formulation of pharmaceutical preparations, cosmetic products, and dietary supplements.
Medium-chain triglycerides (MCT) is used as a solvent for serine proteases and copper complexes in the clinical setting.
Medium-chain triglycerides (MCT) is also an excellent solvent for chemical sunscreens and wetting agent for physical sunscreens.
Medium-chain triglycerides (MCT) are fats that are made in a lab from coconut and palm kernel oils.
Typical dietary fats are called Medium-chain triglycerides (MCT).

Medium-chain triglycerides (MCT)s are a fat source for people who cannot tolerate other types of fats.
These fats might also improve weight loss because the body can more easily break them down into molecules called ketone bodies.
These ketone bodies can be used for energy.
Medium-chain triglycerides (MCT) are triglycerides with two or three fatty acids having an aliphatic tail of 6–12 carbon atoms, i.e. medium-chain fatty acids (MCFAs).
Rich food sources for commercial extraction of MCTs include palm kernel oil and coconut oil.

Medium-chain triglycerides (MCT) is found in palm kernel oil and coconut oil and can be separated by fractionation.
They can also be produced by interesterification.
Retail MCT powder is MCT oil embedded in starch and thus contains carbohydrates in addition to fats.
Medium-chain triglycerides (MCT) is manufactured by spray drying.
Medium-chain triglycerides (MCT) is a supplement made from a type of fat called medium-chain triglycerides.
Medium-chain triglycerides (MCT) molecules are smaller than those in most of the fats you eat (long-chain triglycerides [LCT]).
This makes them easier to digest.

Medium-chain triglycerides (MCT) is obtained from fractionation of a lauric-type oil.
Medium-chain triglycerides (MCT) obtained has a melting point of about 7° C.
When in liquid form, Medium-chain triglycerides (MCT) is almost colourless and with a characteristic odour.
Also known as MCT (medium chain triglyceride).
Medium-chain triglycerides (MCT) has an almost equal composition of caprylic and capric acids.
Fractionated fatty acids are mainly applied to the manufacture of: Amines, esters, fatty alcohols, peroxides, fragrances, flavors, surface finishing, lubricants, metal soaps, cosmetics, animal feed, chemical, paper, plastics, detergents, chemicals, resins and coatings.

Uses
Medium-chain triglycerides (MCT) is widely used in sunscreen oil, cream and lotion; after-sun protection cream and lotion; used in hair modification oil, cream and head oil, which can make the hair shiny, smooth and easy to comb; bath oil; skin care oil and nutrient solution.
Medium-chain triglycerides (MCT) makes the skin lubricated and shiny, and the nutrition is easily absorbed by the skin, which plays a very good role in the uniform and delicate cosmetics.

Calorie restriction
A 2020 systematic review and meta-analysis by Critical Reviews in Food Science and Nutrition supported evidence that MCT decreases subsequent energy intake compared to Medium-chain triglycerides (MCT).
Despite this, Medium-chain triglycerides (MCT) does not appear to affect appetite, and thus the authors stated that further research is required to elucidate the mechanism by which this occurs.

Dietary relevance
Molecular weight analysis of milk from different species showed that while milk fats from all studied species were primarily composed of long-chain fatty acids (16 and 18 carbons long), approximately 10–20% of the fatty acids in milk from horses, cows, sheep, and goats were medium-chain fatty acids.

Some studies have shown that Medium-chain triglycerides (MCT)'s can help in the process of excess calorie burning, thus weight loss.
Medium-chain triglycerides (MCT)s are also seen as promoting fat oxidation and reduced food intake.
Medium-chain triglycerides (MCT)s have been recommended by some endurance athletes and the bodybuilding community.
While health benefits from Medium-chain triglycerides (MCT)s seem to occur, a link to improved exercise performance is inconclusive.
A number of studies back the use of Medium-chain triglycerides (MCT) oil as a weight loss supplement, but these claims are not without conflict, as about an equal number found inconclusive results.

Pharma relevance
Medium-chain triglycerides (MCT)s can be used in solutions, liquid suspensions and lipid-based drug delivery systems for emulsions, self-emulsifying drug delivery systems, creams, ointments, gels and foams as well as suppositories.
Medium-chain triglycerides (MCT)s are also suitable for use as solvent and liquid oily lubricant in soft gels.
Brand names of pharma-grade MCT include Kollisolv MCT 70.

Medical relevance
Medium-chain triglycerides (MCT)s passively diffuse from the GI tract to the hepatic portal system (longer fatty acids are absorbed into the lymphatic system) without requirement for modification like long-chain fatty acids or very-long-chain fatty acids.
In addition, Medium-chain triglycerides (MCT)s do not require bile salts for absorption.
Patients who have malnutrition, malabsorption or particular fatty-acid metabolism disorders are treated with MCTs because MCTs do not require energy for absorption, use, or storage.

Medium-chain triglycerides (MCT)s are generally considered a good biologically inert source of energy that the human body finds reasonably easy to metabolize.
They have potentially beneficial attributes in protein metabolism, but may be contraindicated in some situations due to a reported tendency to induce ketogenesis and metabolic acidosis.
However, there is other evidence demonstrating no risk of ketoacidosis or ketonemia with Medium-chain triglycerides (MCT)s at levels associated with normal consumption, and that the moderately elevated blood ketones can be an effective treatment for epilepsy.

Due to their ability to be absorbed rapidly by the body, medium-chain triglycerides have found use in the treatment of a variety of malabsorption ailments.
Medium-chain triglycerides (MCT) supplementation with a low-fat diet has been described as the cornerstone of treatment for Waldmann disease.
Medium-chain triglycerides (MCT)'s are an ingredient in some specialised parenteral nutritional emulsions in some countries.
Studies have also shown promising results for epilepsy through the use of ketogenic dieting.

Orally ingested Medium-chain triglycerides (MCT) would be very rapidly degraded by first-pass metabolism by being taken up in the liver via the portal vein, and are quickly metabolized via coenzyme A intermediates through β-oxidation and the citric acid cycle to produce carbon dioxide, acetate and ketone bodies.
Whether the ketones β-hydroxybutyrate and acetone have direct antiseizure activity is unclear.

Technical uses
Medium-chain triglycerides (MCT)s are bland compared to other fats and do not generate off-notes (dissonant tastes) as quickly as LCTs.
They are also more polar than LCTs.
Because of these attributes, they are widely used as carrier oils or solvents for flavours and oral medicines and vitamins.

MCT Risks
Medium-chain triglycerides (MCT)’s generally safe to use MCT oil moderately.
But you should be careful when using it long-term.
Some of the negatives include:
Medium-chain triglycerides (MCT) has a lot of calories.
Medium-chain triglycerides (MCT) can cause you to gain weight.
Large amounts of saturated fat may raise your cholesterol.
Medium-chain triglycerides (MCT)s may stimulate the release of hunger hormones, making you overeat.
High doses could lead to fat buildup in the liver.

Synonyms
Caprylic/Capric Triglyceride, CoMMiphora Mukul Resin Extract
2-hydroxy-3-(octanoyloxy)propyldecanoate
1-hydroxy-3-(octanoyloxy)propan-2-yl decanoate
Triglyceride、Hydrogenated Retinol
Medium-Chain Triglycerides (MCT)
Decanoic acid ester with 1,2,3-propanetriol octanoate
decanoyl/octanoyl-glycerides
Octanoic/decanoic triglyceride
Medicago sativa
alfalfa; medicago sativa; extract of the whole plant of the alfa-alfa (alfalfa) or lucerne, medicago sativa l., leguminosae; alfalfa extract, solid (medicago sativa l.); alfalfa fluid extract; alfalfa herb extract; alfalfa herb extract HS 2967 G; alfalfa kiinote (Omega); alfalfa solid extract; extract of the whole plant of the alfa-alfa (alfalfa) or lucerne, medicago sativa l., leguminosae; hydroplastidine medicago (Vevy); vitanol; vitanol bio; CAS NO:84082-36-0
Medium Chain Triglyceride
Medium Chain Triglyceride; MCTs; triglycerides; palm kernel oil; coconut oil; Caprylic acid cas no: 73398-61-5
MEKO
MELAMINE; Cymel; 1,3,5-Triazine-2,4,6-triamine; cyanuramide; cyanuric triamide; triaminotriazine; 2,4,6-triamino-1,3,5-triazine; cyanurotriamide; Teoharn; Theoharn; Virset 656-4; cyanurotriamine; 2,4,6-triamino-s-triazine; s-triaminotriazine; 2,4,6-triamino sym-triazine; 1,3,5-triazine-2,4,6(1H,3H,5H)triimine; cas no: 108-78-1
MELAMIN POLYPHOSPHATE

Melamine polyphosphate is a chemical compound used as a flame retardant and smoke suppressant.
Melamin polyphosphate is commonly used in various applications where fire safety is a concern, such as in plastics, textiles, and coatings.
Melamine polyphosphate is a white, odorless, and non-toxic powder.
Melamin polyphosphate is a type of intumescent flame retardant, which means that it swells and forms a protective char when exposed to heat and flames, reducing the spread of fire and the release of smoke and toxic gases.

CAS Number: 218768-84-4



APPLICATIONS


Melamine polyphosphate is commonly used as a flame retardant in the textile industry to make fabrics fire-resistant, particularly in applications like curtains, upholstery, and protective clothing.
In the construction industry, Melamin polyphosphate is employed to enhance the fire resistance of building materials, such as wood, insulation, and plastics used in electrical enclosures.
Melamin polyphosphate is used in the automotive sector to make fire-resistant components like engine covers, interior trims, and wiring insulation, ensuring safety in the event of a fire.
In the electronics industry, Melamin polyphosphate is used to protect sensitive electronic devices and components by providing flame-resistant properties.

Melamine polyphosphate is commonly found in the manufacturing of printed circuit boards, where fire safety is crucial.
The compound is used to produce fire-resistant coatings and paints for various applications, including building structures, transportation, and marine coatings.

In the aerospace industry, Melamin polyphosphate is employed to meet stringent fire safety standards for aircraft interiors, ensuring passenger safety.
Melamine polyphosphate is used in the formulation of fireproofing materials to protect structural elements in buildings from fire damage.

In the production of electrical cables and wires, Melamin polyphosphate is used as a flame retardant to prevent the spread of fire through electrical systems.
Melamin polyphosphate is incorporated into polymer-based materials, such as polyesters and polyamides, to make them fire-resistant without compromising their integrity.
Melamin polyphosphate is used in the manufacturing of molded plastics and composites, making them suitable for applications where fire safety is critical.

In the transportation industry, Melamin polyphosphate is utilized to enhance the fire safety of vehicles, including trains, buses, and ships.
Melamin polyphosphate is applied to the production of fire-resistant adhesives and sealants, providing enhanced fire protection in construction applications.
Melamine polyphosphate finds applications in the production of fireproof panels used in building interiors and furniture.

In the manufacturing of fire-resistant wallcoverings and wallpapers, Melamin polyphosphate is used to meet safety standards in commercial and residential spaces.
Melamin polyphosphate is used in the formulation of fire barriers and fireproof curtains in industrial and commercial settings.

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Melamin polyphosphate is employed in the creation of fire-resistant foam products used in furniture, mattresses, and other consumer goods.

The paper industry utilizes Melamin polyphosphate to enhance the fire resistance of paper products, especially those used in electrical applications.
In the production of fire-resistant paints and coatings for steel structures and industrial equipment, Melamin polyphosphate helps prevent fires and limit damage.

Melamine polyphosphate is applied in the development of fire-resistant packaging materials for hazardous goods, ensuring safety during storage and transportation.
Melamin polyphosphate is used to create fire-resistant gaskets and seals in the automotive and industrial sectors, preventing the spread of fires and smoke.

Melamin polyphosphate is utilized in fire safety equipment, such as fire extinguisher components, to improve their flame-retardant properties.
In the manufacturing of fire-resistant insulation materials, Melamin polyphosphate helps reduce the risk of fires in residential and commercial buildings.
Melamin polyphosphate is integral to a wide range of fire protection applications, from clothing and furniture to industrial machinery and electrical systems, contributing to improved fire safety and damage prevention.
In the aerospace industry, Melamine polyphosphate is widely used to make aircraft interiors fire-resistant, ensuring passenger safety in the event of a fire.

Melamin polyphosphate is an essential component in the production of fire-resistant composite materials used in aircraft structures, offering enhanced fire protection in aviation.
Melamin polyphosphate is incorporated into fire-resistant textiles for military and industrial applications, protecting personnel and equipment from fire-related hazards.
Melamin polyphosphate is used to manufacture fire-resistant thermal insulation materials for use in buildings, including fireproof doors and walls.
In the automotive industry, Melamin polyphosphate is utilized to create fire-resistant automotive interiors, such as dashboard components and upholstery.
Melamine polyphosphate is found in fire-resistant paints and coatings for steel structures, such as bridges and industrial equipment, to mitigate fire-related damage.

Melamin polyphosphate is a key component in the production of fire-resistant cables and wires, ensuring the safety and reliability of electrical systems.
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In the marine industry, Melamine polyphosphate is employed to make ships and vessels fire-resistant, protecting lives and property on board.
Melamin polyphosphate plays a crucial role in the development of fire-resistant roofing materials, ensuring the safety of residential and commercial buildings.

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In the manufacture of fire-resistant fabrics for uniforms, firefighter gear, and emergency response apparel, Melamin polyphosphate is a critical flame retardant.

Melamin polyphosphate is applied in the production of fire-resistant mattresses and bedding materials to enhance fire safety in homes and hotels.
Melamine polyphosphate is used to create fire-resistant foam products, making them suitable for furniture and upholstery applications.

Melamin polyphosphate is a key component in the production of fire-resistant insulation materials used in residential and commercial buildings.
Melamin polyphosphate is employed in the manufacturing of fire-resistant gaskets and seals in industrial equipment and appliances to prevent fire spread.

The medical industry uses Melamin polyphosphate to produce fire-resistant healthcare products and equipment, ensuring safety in healthcare settings.
In the oil and gas industry, Melamin polyphosphate is applied to enhance the fire resistance of materials used in offshore platforms and drilling equipment.

Melamine polyphosphate is used in the formulation of fire-resistant coatings for industrial equipment and machinery, reducing fire risks in industrial settings.
The construction industry employs Melamin polyphosphate in the production of fire-resistant building materials, including fireproof doors, windows, and structural components.
Melamin polyphosphate is an essential component in the development of fire-resistant paints and varnishes for wood and other building materials.
Melamin polyphosphate is utilized in the manufacturing of fire-resistant sealants and adhesives used in construction and industrial applications.
The textile industry relies on Melamine polyphosphate to create fire-resistant fabrics for home furnishings, automotive interiors, and industrial applications.

Melamin polyphosphate is found in fire-resistant curtains, drapes, and wallcoverings, enhancing fire safety in commercial and residential spaces.
Melamin polyphosphate is an integral component in the production of fire-resistant packaging materials for hazardous goods, preventing fire-related accidents during storage and transportation.

The pharmaceutical industry uses Melamine polyphosphate to manufacture fire-resistant packaging materials for pharmaceutical products, ensuring the safety of medications during storage and transport.
Melamin polyphosphate is applied in the production of fire-resistant cable trays, ductwork, and conduit systems used in industrial and commercial settings to minimize fire risks.
In the event of a fire, Melamine polyphosphate is used in fire extinguishing systems, where it acts as a fire suppressant, reducing the risk of fire damage and injuries.

Melamin polyphosphate is found in the formulation of fire-resistant sealants used in firestopping applications, preventing the spread of fire and smoke through openings in buildings.
Melamin polyphosphate is integral in the development of fire-resistant glazing systems and windows for residential and commercial buildings.
In the manufacturing of fire-resistant containers for hazardous materials and chemicals, Melamine polyphosphate ensures safety during storage and transportation.

Melamin polyphosphate is used in the creation of fire-resistant wallpapers and wallcoverings for homes, offices, and public spaces.
Melamin polyphosphate is employed to make fire-resistant acoustical panels, contributing to safety in concert halls, theaters, and recording studios.

The signage industry uses Melamine polyphosphate to create fire-resistant sign materials, ensuring safety in public buildings and transportation systems.
In the production of fire-resistant wall and ceiling panels for industrial and commercial applications, Melamin polyphosphate enhances fire safety.
The insulation industry incorporates Melamin polyphosphate into fire-resistant insulation materials used in HVAC systems and buildings.
Melamine polyphosphate is used in the development of fire-resistant ceiling grids and tiles, improving safety in suspended ceiling systems.

In the aerospace industry, Melamin polyphosphate is applied to make fire-resistant cabin interiors, ensuring passenger safety in aircraft.
The military utilizes Melamin polyphosphate in the production of fire-resistant military gear, including uniforms, equipment, and vehicle components.

Melamin polyphosphate is an essential component in the development of fire-resistant air filters for HVAC systems, contributing to safety in commercial and residential buildings.
Melamin polyphosphate is applied in the manufacturing of fire-resistant wall panels for cleanroom environments, such as laboratories and pharmaceutical facilities.

In the transportation industry, it is used to make fire-resistant vehicle interiors, including trains, buses, and ships.
Melamine polyphosphate finds applications in the production of fire-resistant roller shutters and doors for commercial and industrial buildings.
The mining industry utilizes Melamin polyphosphate to create fire-resistant conveyor belts and equipment components for underground operations.
Melamin polyphosphate is employed in the production of fire-resistant barrier systems used in tunnels, subways, and underground structures.
Melamin polyphosphate is integral in the development of fire-resistant soundproofing materials for use in construction and industrial settings.

The nuclear industry uses Melamine polyphosphate to create fire-resistant materials for nuclear power plants, ensuring safety in critical infrastructure.
In the event of wildfires, Melamin polyphosphate is applied to protect structures with fire-resistant coatings and barrier systems.
The sports and recreation industry uses Melamin polyphosphate in the production of fire-resistant sports equipment and gear, improving player safety.

Melamin polyphosphate is found in the formulation of fire-resistant stage props and scenic materials for theaters and performance venues.
In the defense industry, Melamin polyphosphate is used to make fire-resistant military vehicles, protecting personnel and equipment from fire-related threats in combat zones.
The aviation industry relies on Melamin polyphosphate for the production of fire-resistant cargo containers and aircraft cargo compartments.

Melamin polyphosphate is applied in the development of fire-resistant carpeting and flooring materials for commercial and residential use, reducing fire hazards.
Melamin polyphosphate is used in the creation of fire-resistant blankets and fireproof curtains for emergency response and firefighting applications.

The hospitality industry incorporates Melamin polyphosphate into fire-resistant furnishings for hotels and resorts to ensure the safety of guests.
In industrial kitchens, Melamin polyphosphate is found in fire-resistant materials used for appliances and equipment, preventing kitchen fires.
The petrochemical industry uses Melamin polyphosphate in the production of fire-resistant materials for oil and gas facilities and pipelines.

Melamin polyphosphate is applied in the manufacturing of fire-resistant conveyor systems used in warehouses and distribution centers.
Melamin polyphosphate is utilized in the development of fire-resistant sails and fabrics for sailing vessels, enhancing safety during maritime activities.

The automotive racing industry relies on Melamin polyphosphate to create fire-resistant racing suits, gloves, and helmets for drivers.
In laboratory settings, it is used to produce fire-resistant laboratory equipment and materials, reducing the risk of chemical and electrical fires.
Melamin polyphosphate is incorporated into the production of fire-resistant fire doors and emergency exits in commercial and industrial buildings.

Melamin polyphosphate is found in the formulation of fire-resistant soundproofing materials for use in concert halls, theaters, and recording studios.
The agriculture industry utilizes Melamin polyphosphate to create fire-resistant materials for farming equipment, such as combine harvesters.
In the petrochemical sector, it is employed in the production of fire-resistant piping and pipe insulation for oil refineries and chemical plants.
Melamin polyphosphate is used in the development of fire-resistant electrical panels and switchgear for industrial and commercial applications.
The energy industry relies on Melamin polyphosphate to produce fire-resistant materials for power plants and utility infrastructure.

In the manufacturing of fire-resistant safes and vaults, it enhances the security and safety of valuable possessions.
Melamin polyphosphate is applied in the production of fire-resistant elevators and elevator components, ensuring safe evacuation during emergencies.

The pulp and paper industry utilizes Melamin polyphosphate to create fire-resistant materials for paper mills, reducing fire hazards in the production process.
In underground mining operations, it is found in fire-resistant materials used for mining equipment, tunnels, and conveyors.

Melamin polyphosphate is incorporated into the development of fire-resistant agricultural structures and greenhouses, protecting crops and livestock.
In public transportation, Melamin polyphosphate is used to create fire-resistant seats, upholstery, and interior components for buses and trains.
The energy generation industry employs Melamin polyphosphate in the production of fire-resistant materials for wind turbine components and solar power installations.
Melamin polyphosphate is essential in the production of fire-resistant architectural elements, such as fireplaces, mantels, and decorative columns, enhancing safety and aesthetics in homes and commercial spaces.

In the maritime industry, Melamin polyphosphate is used in the manufacturing of fire-resistant life vests and personal flotation devices to enhance safety for sailors and passengers.
The aviation sector relies on Melamin polyphosphate for making fire-resistant aircraft seating materials, ensuring passenger safety on commercial and private flights.
Melamin polyphosphate is applied in the production of fire-resistant marine upholstery and seating for boats, yachts, and cruise ships.

Melamin polyphosphate is found in the formulation of fire-resistant window blinds and shades for homes and commercial buildings.
In the event of wildfires, it is used to treat vegetation and foliage with fire-retardant solutions to prevent the spread of wildfires near populated areas.
The film and entertainment industry incorporates Melamin polyphosphate into the development of fire-resistant props and set materials for film and television productions.
In laboratories and research facilities, it is used in the production of fire-resistant laboratory furniture and workstations to protect equipment and experiments.
Melamin polyphosphate is applied in the manufacturing of fire-resistant power distribution equipment for utilities and substations.

The petrochemical sector utilizes it to make fire-resistant materials for oil and gas pipelines and storage tanks.
In the automotive industry, Melamin polyphosphate is found in the production of fire-resistant automotive airbag covers and restraint systems.
Melamin polyphosphate is used in the development of fire-resistant materials for petrochemical storage tanks and refineries, reducing fire risks in industrial facilities.
Melamin polyphosphate is employed to create fire-resistant insulated panels used in cold storage and refrigeration facilities.

In the marine industry, Melamin polyphosphate is utilized to produce fire-resistant ship doors, bulkheads, and marine safety equipment.
Melamin polyphosphate is incorporated into the manufacturing of fire-resistant building facades and cladding systems for commercial and residential structures.

The food and beverage industry uses it to create fire-resistant conveyor systems and materials for food processing facilities.
In agriculture, Melamin polyphosphate is applied in the production of fire-resistant agricultural equipment, such as tractors and grain storage facilities.



DESCRIPTION


Melamine polyphosphate is a chemical compound used as a flame retardant and smoke suppressant.
Melamin polyphosphate is commonly used in various applications where fire safety is a concern, such as in plastics, textiles, and coatings.
Melamine polyphosphate is a white, odorless, and non-toxic powder.
Melamin polyphosphate is a type of intumescent flame retardant, which means that it swells and forms a protective char when exposed to heat and flames, reducing the spread of fire and the release of smoke and toxic gases.
Melamin polyphosphate has the chemical formula (C3H6N6)n(H3PO4)n and is often produced as a mixture of melamine and polyphosphoric acid.

Melamin polyphosphate is used in a wide range of industries and materials to improve fire resistance and safety.
Melamin polyphosphate is especially prevalent in applications where conventional flame retardants may not be suitable due to toxicity concerns or where the material's physical properties need to be maintained.

Melamine polyphosphate is one of several flame retardants designed to meet fire safety standards and regulations in various products, including textiles, plastics, adhesives, and coatings.
Melamin polyphosphate is considered an effective and environmentally friendly alternative in the realm of flame retardant chemicals.

Melamine polyphosphate, also known as Melamin polyphosphate, is a flame retardant chemical used to enhance the fire resistance of various materials.
This white, fine, crystalline powder is odorless and non-toxic, making it suitable for a wide range of applications.
Melamine polyphosphate belongs to the category of intumescent flame retardants, which expand and form a protective char when exposed to high temperatures.

Melamin polyphosphate has the chemical formula (C3H6N6)n(H3PO4)n, indicating a polymeric structure that consists of repeating units of melamine and polyphosphoric acid.
Melamin polyphosphate is known for its ability to reduce the spread of flames and suppress smoke and toxic gas emissions during a fire event.
Melamin polyphosphate is widely used in industries where fire safety is a significant concern, such as construction, textiles, plastics, and coatings.

Melamine polyphosphate is an environmentally friendly flame retardant, as it does not contain harmful halogenated compounds or heavy metals.
When exposed to heat, it decomposes to release ammonia and water, which dilute and cool the combustion zone, limiting fire propagation.
The formation of a stable, insulating char layer on the material's surface helps prevent further heat and flame penetration.

Melamin polyphosphate is a versatile flame retardant suitable for various polymers, including polyesters, polyamides, and epoxy resins.
Melamin polyphosphate is often used in combination with other flame retardants to achieve optimal fire protection in specific applications.
Melamin polyphosphate is commonly applied in the production of flame-resistant textiles, such as curtains, upholstery, and protective clothing.

In the plastics industry, melamine polyphosphate is used to make products like electrical enclosures, automotive components, and electronic devices fire-resistant.
Melamin polyphosphate finds applications in coatings and paints, enhancing their fire resistance in construction and transportation sectors.
Melamin polyphosphate is known for its ability to maintain the physical properties of treated materials while providing fire protection.
Melamine polyphosphate is stable under normal storage conditions and is not prone to decomposition or degradation.
The flame-retardant properties of Melamin polyphosphate comply with industry standards and regulations, ensuring products meet fire safety requirements.

Melamin polyphosphate can be incorporated into materials through various processing methods, including blending, compounding, or coating.
Melamine polyphosphate is compatible with different polymer matrices, making it suitable for a wide range of materials.
Its use is prevalent in aerospace applications, where materials must meet stringent fire safety criteria.
The combination of melamine and polyphosphoric acid imparts self-extinguishing properties to materials.
Melamin polyphosphate is designed to act as a safeguard against the rapid spread of flames, reducing the risk of fire-related injuries and damage.

Melamin polyphosphate is an essential component in fire-resistant paints used for building structures and fireproofing applications.
Melamine polyphosphate is part of ongoing efforts to improve fire safety and protect lives and property from the devastating effects of fires.
Its versatility, eco-friendliness, and effectiveness make melamine polyphosphate a valuable tool in achieving fire-resistant materials in various industries.



PROPERTIES


Chemical Formula: Melamin polyphosphate has a chemical formula represented as (C3H6N6)n(H3PO4)n, indicating its polymeric structure, composed of repeating units of melamine and polyphosphoric acid.
Physical State: Melamin polyphosphate is typically found in a fine, white, crystalline powder form.
Odor: It is odorless.
Toxicity: Melamin polyphosphate is generally considered non-toxic and safe for many applications.
Flame Retardancy: One of its key properties is its ability to impart flame resistance to various materials. When exposed to fire, it decomposes and forms a protective char layer, which acts as a barrier to flames.
Flame-Suppressing Action: Melamin polyphosphate releases ammonia and water when exposed to heat, diluting and cooling the combustion zone, thus suppressing the spread of flames.
Intumescence: Melamin polyphosphate is part of intumescent flame retardants that expand and create an insulating layer when exposed to high temperatures.
Decomposition Temperature: It has a specific decomposition temperature at which it begins to release ammonia and water, contributing to fire suppression.
Thermal Stability: Melamin polyphosphate exhibits thermal stability under normal storage conditions, maintaining its flame-retardant properties.
Polymeric Structure: It consists of a polymeric network, indicating the presence of multiple repeating units in its structure.
Solubility: Melamin polyphosphate is typically not highly soluble in water, which can be an advantage in applications where water exposure is a concern.
Compatibility: It is compatible with various polymer matrices, making it versatile in different material applications.
Environmental Safety: Melamin polyphosphate is known for its eco-friendly and non-toxic nature, as it does not contain harmful halogenated compounds or heavy metals often found in other flame retardants.
Insulating Properties: When exposed to heat, Melamin polyphosphate forms an insulating char layer that protects the underlying material and prevents further heat and flame penetration.
Physical Form: It is often supplied in a finely ground powder form, making it easy to incorporate into various materials.
Combustion Byproducts: Its decomposition primarily releases ammonia and water, which are less harmful byproducts compared to some other flame retardants.
Density: Melamin polyphosphate has a specific density that can vary depending on the grade and processing.



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air immediately.
If the person is not breathing, perform artificial respiration.
Seek immediate medical attention and provide information about the chemical involved.


Skin Contact:

In case of skin contact, remove contaminated clothing and wash the affected skin with plenty of water for at least 15 minutes.
Use mild soap if available.
Avoid using harsh chemicals or solvents on the skin.
If irritation, redness, or other adverse skin reactions occur, seek medical attention.
Wash contaminated clothing separately before reuse.


Eye Contact:

If Melamin polyphosphate comes into contact with the eyes, immediately flush the eyes with gently flowing, lukewarm water for at least 15 minutes.
Ensure that the eyelids are held open and the entire eye surface is rinsed.
Seek immediate medical attention, even if there is no immediate discomfort or visible injury.


Ingestion:

If ingested accidentally, do not induce vomiting unless instructed by medical professionals.
Rinse the mouth thoroughly with water and drink plenty of water or milk if the person is conscious.
Seek immediate medical attention and provide information about the ingested substance.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles, and a lab coat or protective clothing, when handling Melamin polyphosphate.
Use a dust mask if there is a risk of inhalation exposure.

Ventilation:
Ensure adequate ventilation in the working area to prevent the build-up of dust or fumes.
Use local exhaust ventilation or mechanical ventilation systems if necessary.

Avoid Contact:
Minimize skin and eye contact with Melamin polyphosphate.
Wash hands and any exposed skin thoroughly after handling.
In case of contact, follow the first aid measures provided in the event of exposure.

Prevent Ingestion:
Do not eat, drink, or smoke while working with Melamin polyphosphate.
Avoid any activity that might lead to accidental ingestion.

Storage Containers:
Use appropriate containers for storage, such as plastic or glass containers with tight-fitting lids, to prevent moisture exposure.
Ensure that storage containers are labeled with the product name and hazard information.

Avoid Mixing:
Do not mix Melamin polyphosphate with incompatible materials or chemicals.
Review the safety data sheet (SDS) for guidance on safe handling and storage.

Handling Precautions:
Handle Melamin polyphosphate with care to prevent dust formation, spillage, or release into the environment.
Use non-sparking tools when necessary.

Waste Disposal:
Dispose of waste and empty containers in accordance with local, state, and federal regulations.
Follow established waste disposal procedures for chemical substances.

Training:
Ensure that personnel handling Melamin polyphosphate are adequately trained in safe handling practices and are aware of the potential hazards associated with the chemical.


Storage:

Storage Location:
Store Melamin polyphosphate in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible materials.
Keep it in a dedicated storage area with appropriate hazard labeling.

Temperature:
Maintain storage temperatures within the recommended range specified on the product's safety data sheet.

Moisture Control:
Prevent moisture exposure, as Melamin polyphosphate can be slightly sensitive to moisture.
Use moisture-resistant packaging or containers to maintain product integrity.

Avoid Contaminants:
Store Melamin polyphosphate away from potential contaminants, such as strong acids, bases, and reducing agents, which could react with the chemical.

Handling and Storage Compatibility:
Store Melamin polyphosphate separately from incompatible materials, and review the compatibility of materials in the storage area.

Keep Containers Closed:
Ensure that storage containers are tightly closed when not in use to prevent moisture ingress and contamination.



SYNONYMS


Melamine phosphate
Melamin polyphosphate
Melam
Melamine-phosphoric acid complex
Polyphosphoric acid melamine salt
Fire retardant melamine polyphosphate
Melamine polyphosphate flame retardant
Melamine-phosphate complex
Flame-safe melamine polyphosphate
Phosphoric acid melamine salt
Fire-block melamine polyphosphate
Melamine-polyphosphoric acid compound
Melamine fire suppressant
Melamin polyphosphate flame inhibitor
Melamine flame-resistant additive
Phosphoric acid melaminate
Melamine-based fire inhibitor
Melamine polyphosphate fire suppressor
Melamin polyphosphate flame-retardant agent
Phosphate ester of melamine
Flame-stopping melamine compound
Melamine fire safety additive
Melamine polyphosphate fire blocker
Melamine-based flame stopper
Melamin polyphosphate fire safety compound
Melamine polyphosphonate
Melamine-phosphorus compound
Fire-resistant melamine salt
Melamin polyphosphate flame inhibitor
Melamine phosphate flame retardant
Melamine polyphosphate flame suppressant
Melamine-based fire suppressor
Melamine fire safety agent
Flame-resistant melamine compound
Melamine polyphosphonate fire retardant
Melamine phosphonate
Melamin polyphosphate flame-resistant additive
Melamine flame retardant
Melamine polyphosphate fire blocker
Flame-stopping melamine-phosphorus compound
Fire-safe melamine polyphosphate
Phosphate ester of melamine
Melamine fire inhibitor
Melamine fire suppressant
Melamine fire-retardant agent
Melamine flame-retardant additive
Fire-block melamine polyphosphate
Phosphoric acid melamine salt
Melamine-polyphosphoric acid complex
Fire-resistive melamine phosphate
MELAMINE
Melamine has a role as a xenobiotic metabolite.
Melamine is functionally related to a cyanamide.
Melamine is a conjugate base of a melamine(1+).


CAS Number: 108-78-1
Molecular Formula: C3H6N6 / C3N3(NH2)3



SYNONYMS:
1,3,5-Triazine-2,4,6-triamine, Metformin Hydrochloride Imp. D (EP), Melamine, Metformin Imp. D (EP), Metformin Hydrochloride Impurity D, Metformin Impurity D, 2,4,6-triamino-1,3,5-triazine, melamine, 1,3,5-triazine-2,4,6-triamine, [1,3,5]triazine-2,4,6-triamine, s-triazine, 4,6-diamino-1,2-dihydro-2-imino-, 2,4,6-triamino-1,3,5-triazine melamine 1,3,5-triazine-2,4,6-triamine [1,3,5]triazine-2,4,6-triamine s-triazine, 4,6-diamino-1,2-dihydro-2-imino-, 1,3,5-Triazine-2,4,6-triamine, 2,4,6-Triamino-s-triazine, Cyanurotriamide, Cyanurotriamine, Cyanuramide, MELAMINE, 1,3,5-Triazine-2,4,6-triamine, 108-78-1, Cyanuramide, Cyanurotriamide, Cyanurotriamine, Isomelamine, Theoharn, Teoharn, Triaminotriazine, Cyanuric triamide, Hicophor PR, s-Triazinetriamine, Aero, Pluragard, Yukamelamine, 2,4,6-Triamino-s-triazine, Cymel, Virset 656-4, 2,4,6-Triamino-1,3,5-triazine, Spinflam ML 94M, Pluragard C 133, 2,4,6-Triaminotriazine, Mark ZS 27, ADK Stab ZS 27, DG 002 (amine), NCI-C50715, Melamine Monomer, s-triaminotriazine, DTXSID6020802, s-Triazine, 2,4,6-triamino-, sym-Triaminotriazine, ZS 27, NSC 2130, 1,3,5-Triazine-2,4,6(1H,3H,5H)-triimine, CCRIS 373, DG 002, Cyanurtriamide, HSDB 2648, UNII-N3GP2YSD88, 1246816-14-7, EINECS 203-615-4, N3GP2YSD88, 2,4,6-triamino sym-triazine, BRN 0124341, CHEBI:27915, AI3-14883, NSC-2130, DTXCID40802, 1,3,5-triazine-2,4,6(1H,3H,5H)triimine, EC 203-615-4, Melamine 100 microg/mL in Water, 4-26-00-01253 (Beilstein Handbook Reference), 5432-64-4, MELAMINE (IARC), MELAMINE [IARC], 1,3,5-Triazine-2,4,6-triamine (Melamine), Melamine 100 microg/mL in Acetonitrile/Water, MELAMINE (USP-RS), MELAMINE [USP-RS], s-Triazine, 4,6-diamino-1,2-dihydro-2-imino-, triamino-s-triazine, Melamine, 99%, Melamine (1.0 mg/10 mL in 84:16% ACN, ), METFORMIN HYDROCHLORIDE IMPURITY D (EP IMPURITY), METFORMIN HYDROCHLORIDE IMPURITY D [EP IMPURITY], melamin, AX2, CYANURTRIAMINE, 2,6-Triaminotriazine, CYMEL (Salt/Mix), MELAMINE [HSDB], 2,4,6-Triamino-1,3,5-triazine Monomer, MELAMINE [MI], 2,6-Triamino-s-triazine, s-Triazine, 4,6-triamino-, SCHEMBL25853, Melamine, analytical standard, BIDD, , MA-1-H2O, CHEMBL1231106, SCHEMBL12192199, 1,5-Triazine-2,4,6-triamine, 2,6-Triamino-1,3,5-triazine, NSC2130, NSC8152, HY-Y1117, NSC-8152, WLN: T6N CN ENJ BZ DZ FZ, Tox21_200503, 1,3,5-triazinane-2,4,6-triimine, BBL000010, MFCD00006055, s9212, STK378738, [1,3,5]triazine-2,4,6-triamine, 1,3,5-Triazine-2,4,6-triamine, 2,4,6-Triamino-1,3,5-triazine, AKOS005448714, 1,3,5-Triazine, 2,4,6-triamino-, CCG-266105, NCGC00164014-01, NCGC00164014-02, NCGC00258057-01, AC-34715, CAS-108-78-1, VS-00405, 1,3,5-Triazine-2,4,6-triamine monomer, Melamine 1.0 mg/ml in Dimethyl Sulfoxide, CS-0016866, NS00010262, T0337, 1,5-Triazine-2,4,6(1H,3H,5H)-triimine, EN300-71605, 4,6-Diamino-1,2-dihydro-2-imino-S-Triazine, C08737, E76265, Q212553, J-002191, 1,3,5-Triazine-2,4,6-triamine (ACD/Name 4.0), 2,4,6-Triamino-1,3,5-triazine, sym-Triaminotriazine, Z1142688822, Melamine, >=95.0% (HPLC), pharmaceutical impurity standard, Melamine, United States Pharmacopeia (USP) Reference Standard, Melamine, Pharmaceutical Secondary Standard; Certified Reference Material



Melamine /ˈmɛləmiːn/ ⓘ is an organic compound with the formula C3H6N6.
This white solid, Melamine, is a trimer of cyanamide, with a 1,3,5-triazine skeleton.
Like cyanamide, Melamine contains 66% nitrogen by mass, and its derivatives have fire-retardant properties due to its release of nitrogen gas when burned or charred.


Melamine can be combined with formaldehyde and other agents to produce melamine resins.
Melamine is one of the major components in Pigment Yellow 150, a colorant in inks and plastics.
Melamine is a chemical present in many products, including reusable plastic dishware.


It is safe to use but Melamine can migrate from dishes to foods, particularly acidic ones like tomatoes.
Melamine is a nitrogen-based compound used by many manufacturers to create a number of products, especially plastic dishware.
Melamine’s also used in: utensils, countertops, plastic products, dry-erase boards, paper products.


Melamine appears as colorless to white monoclinic crystals or prisms or white powder.
Melamine sublimes when gently heated.
Melamine is a trimer of cyanamide, with a 1,3,5-triazine skeleton.


Melamine has a role as a xenobiotic metabolite.
Melamine is functionally related to a cyanamide.
Melamine is a conjugate base of a melamine(1+).


Melamine is a natural product found in Apis cerana, Euglena gracilis, and Aeromonas veronii with data available.
Melamine is an organic base and a trimer of cyanamide, with a 1,3,5-triazine skeleton.
Like cyanamide, Melamine contains 66% nitrogen by mass and, if mixed with resins, has fire retardant properties due to its release of nitrogen gas when burned or charred, and has several other industrial uses.


Melamine is also a metabolite of cyromazine, a pesticide.
Melamine is formed in the body of mammals who have ingested cyromazine.
Melamine has been reported that cyromazine can also be converted to melamine in plants.


Such resins are characteristically durable thermosetting plastic used in high pressure decorative laminates such as Formica, melamine dinnerware including cooking utensils, plates, plastic products, laminate flooring, and dry erase boards.
Melamine foam is used as insulation, soundproofing material and in polymeric cleaning products, such as Magic Eraser.


Melamine, a colourless crystalline substance belonging to the family of heterocyclic organic compounds, which are used principally as a starting material for the manufacture of synthetic resins.
Melamine is rich in nitrogen, a property that is similar to protein.


Melamine has also been incorporated into a variety of flame-retardant materials.
When exposed to heat, melamine degrades and releases nitrogen.
The freed nitrogen takes the place of oxygen in the surface air surrounding the material, which prevents the material from burning.


Butylated melamine resins, made by incorporating butyl alcohol into the melamine–formaldehyde reaction mixture, are fluids used as ingredients of paints and varnishes.
A copolymer containing melamine, formaldehyde, and sodium bisulfite produces a foam with sound-absorbing and flame-retardant properties.


The foam has a notably hard microbubble structure, which gives it an abrasive quality that has been utilized in the development of cleaning products.
Melamine is a long-lasting chemical that is hard to break down and can be used for many years.
Melamine, which is flame retardant and heat resistant due to the nitrogen forming 66% of mass, becomes a hard and hard breaker which is insoluble in water when combined with formaldehyde.


Melamine is an organic-based, nitrogen-rich compound used to manufacture cooking utensils, plates, plastic products, and more.
Melamine resin is durable, fire and heat resistant and virtually unbreakable, making melamine products more desirable than other plastic housewares.
Melamine is a chemical compound.


When combined with formaldehyde, Melamine hardens.
Melamine is a chemical compound with the chemical formula C3H6N6.
Melamine exists as a white crystalline powder or granules and is often used in the production of certain industrial products due to its high strength, hardness, and durability.



USES and APPLICATIONS of MELAMINE:
Melamine is a widely-used intermediate, mainly employed as a raw material for producing melamine resin and is a chemical most often found in plastic materials.
Melamine is an inexpensive synthetic compound that when combined with formaldehyde becomes melamine resin.


This melamine formaldehyde resin is used in making melamine dishware, hard plastic tableware.
Melamine also is used in the fabrication of melamine polysulfonate, used as a superplasticizer for making high-resistance concrete.
Sulfonated melamine formaldehyde (SMF) is a polymer used as a cement admixture to reduce the water content in concrete while increasing the fluidity and the workability of the mix during handling and pouring.


It results in concrete with a lower porosity and a higher mechanical strength, exhibiting an improved resistance to aggressive environments and a longer lifetime.
Melamine foam is used as insulation, soundproofing material and in polymeric cleaning products, such as Magic Eraser.


Medicine uses of Melamine: Melamine derivatives of arsenical drugs are potentially important in the treatment of African trypanosomiasis.
The usage area of melamine is quite wide but widely; it is used in the production of tableware and kitchen utensils.
Also, melamine is used in the manufacture of many different products such as kitchen cabinets and benches, sound insulation products, various fabrics, flame retardant chemicals, cleaning materials, whiteboards, flooring, manure, and animal feed as well as the raw materials.


Melamine is a chemical that has many industrial uses.
In the United States, Melamine is approved for use in the manufacturing of some cooking utensils, plates, plastic products, paper, paperboard, and industrial coatings, among other things.


In addition, although Melamine is not registered as a fertilizer in the U.S., melamine has been used as a fertilizer in some parts of the world.
Melamine may be used in the manufacturing of packaging for food products, but is not FDA-approved for direct addition to human food or animal feeds marketed in the U.S.


Melamine is produced by reacting formaldehyde and ammonia.
In industry, this reaction is commonly used to create products for various purposes, such as melamine-coated boards, insulation materials, coatings, adhesives, high-strength plastics, and various consumer goods.


Melamine is also used in some food products.
For example, melamine resins are used to thicken preserves, and Melamine has been illicitly added to dairy products to fraudulently increase protein content.


However, excessive consumption of melamine has been shown to pose health risks, leading to regulations and limitations on its use in the food industry.
Melamine is a versatile chemical compound used in various industries.
Construction Materials Industry uses of Melamine: Melamine is used in the production of construction materials such as furniture, laminate flooring, kitchen countertops, and wall panels due to its fire resistance, water resistance, and durability.


Chemical Industry: Melamine is used in the production of synthetic resins, plastics, coatings, adhesives, paints, and inks, among other chemical products.
Agricultural Industry: Melamine is used to produce protein supplements used in animal feed.
Textile Industry: Melamine is used in the production of reactive dyes used in textile dyeing and printing processes.


Electrical Industry: Melamine is used in the production of compounds that provide electrical insulation.
Automotive Industry: Melamine is used in vehicle coatings and as a paint additive.


-Personal Care Industry uses of Melamine:
Melamine is used as a hardening agent in hair straighteners and nail polishes.
In addition to these industries, melamine has various other applications.


-Plastics and building materials uses of Melamine:
In one large-scale application, melamine is combined with formaldehyde and other agents to produce melamine resins.
Such resins are characteristically durable thermosetting plastic used in high-pressure decorative laminates such as Wilsonart, melamine dinnerware, laminate flooring, and dry erase boards.
Melamine cookware is not microwave-safe.


-Fire-retardant additives uses of Melamine:
Melamine and its salts are used as fire-retardant additives in paints, plastics, and paper.
A melamine fiber, Basofil, has low thermal conductivity, excellent flame resistance and is self-extinguishing; this makes it useful for flame-resistant protective clothing, either alone or as a blend with other fibres.


-Food additive uses of Melamine:
Melamine is sometimes illegally added to food products in order to increase the apparent protein content.
Standard tests, such as the Kjeldahl and Dumas tests, estimate protein levels by measuring the nitrogen content, so they can be misled by the addition of nitrogen-rich, but non-proteinaceous compounds such as melamine.
There are instruments available today that can differentiate melamine nitrogen from protein nitrogen.


-Fertilizers use of Melamine:
Melamine was once envisioned as fertilizer for crops during the 1950s and 1960s because of its high nitrogen content (2/3).
However, melamine is much more expensive to produce than other common nitrogen fertilizers, such as urea.
The mineralization (degradation to ammonia) for melamine is slow, making this product both economically and scientifically impractical for use as a fertilizer.



MANUFACTURE AND APPLICATIONS OF MELAMINE:
Melamine can be manufactured from dicyandiamide, hydrogen cyanide, or urea.
Modern commercial production of melamine typically employs urea as a starting material.
Urea is broken down to cyanuric acid, which then can be reacted to form melamine.

Its most important reaction is that with formaldehyde, forming melamine-formaldehyde resins of high molecular weight.
These compounds form under the influence of heat and then become fixed into an insoluble and infusible mold; this process is known as thermosetting.
Melamine-based thermoset materials contain cross-linked polymers, which make the fixed molds strong and durable.

Usually formulated with fillers and pigments, melamine resins can be molded into dishes, containers, utensils, handles, and the like or used as laminating agents or coating materials for wood, paper, and textiles.
Formica and Melmac are well-known trade names for products based on melamine resins.



ETYMOLOGY OF MELAMINE:
The German word Melamin was coined by combining the words melam (a derivative of ammonium thiocyanate) and amine.
Melamine is, therefore, unrelated etymologically to the root melas (μέλας, meaning 'black' in Greek), from which the words melanin, a pigment, and melatonin, a hormone, are formed.



HOW IS MELAMINE PRODUCED?
Melamine is a chemical compound obtained by the reaction of urea and cyanide at high temperatures.
Generally, the production of melamine involves the following steps:

*Urea and Cyanide Preparation: Urea and cyanide are prepared separately and stored.
*Reaction Preparation: Urea and cyanide are mixed in appropriate proportions and purified to create a suitable environment for the reaction.



REACTION OF MELAMINE:
The mixture of urea and cyanide is reacted in a reactor at temperatures of 350-400°C to produce melamine.
Crystallization: The resulting melamine from the reaction is mixed with water and cooled to allow for crystallization.
Drying and Grinding: The obtained melamine crystals are dried and ground.

Purification and Packaging: Melamine is purified and packaged in suitable packaging for various industries.
Since the production of melamine is complex and potentially hazardous, proper precautions and requirements must be followed.
This process should be carried out by trained and experienced personnel.



WHAT ARE THE BENEFITS OF USING MELAMINE INSTEAD OF TRADITIONAL CERAMIC OR PORCELAIN?
Melamine is the best quality food-safe plastic on the market.
It's durable, easy to clean and has anti-bacterial properties.

Q Squared resembles the look of ceramic and porcelain, but it is shatter-resistant and easier to handle.
Melamine can withstand the rigors of everyday use and is more resistant to scratch marks and use and abuse over time. Our dinnerware and serveware is also perfect for both indoor and outdoor dining and entertaining.



PHYSICAL and CHEMICAL PROPERTIES of MELAMINE:
Chemical formula: C3H6N6
Molar mass: 126.123 g·mol−1
Appearance: White solid
Density: 1.573 g/cm³
Melting point: 343 °C (649 °F; 616 K) (decomposition)
Boiling point: Sublimes
Solubility in water: 3240 mg/L (20 °C)
Solubility: Very slightly soluble in hot alcohol,
benzene, glycerol, pyridine;
insoluble in ether, benzene, CCl4
log P: −1.37
Acidity (pKa): 5.0 (conjugated acid)
Basicity (pKb): 9.0

Magnetic susceptibility (χ): −61.8·10−6 cm³/mol
Refractive index (nD): 1.872
Structure
Crystal structure: Monoclinic
Thermochemistry
Std enthalpy of combustion (ΔcH⦵298): −1967 kJ/mol
Molecular Weight: 126.12 g/mol
XLogP3: -1.4
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 0
Exact Mass: 126.06539422 g/mol
Monoisotopic Mass: 126.06539422 g/mol

Topological Polar Surface Area: 117Ų
Heavy Atom Count: 9
Formal Charge: 0
Complexity: 63.3
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical property: White Powder
Chemical Formula: C3H6N6
Molecular weight: 126.12 g/mol



FIRST AID MEASURES of MELAMINE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of MELAMINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of MELAMINE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MELAMINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MELAMINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of MELAMINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


MELAMINE
MELANIN, melanine, N° CAS : 8049-97-6. Nom INCI : MELANIN. N° EINECS/ELINCS : 232-473-6. Ses fonctions (INCI) : Agent de protection de la peau : Aide à éviter les effets néfastes des facteurs externes sur la peauLe mot mélanine est un mot générique qui désigne de nombreux pigments biologiques foncés qui sont notamment responsables de la coloration des téguments dans le règne animal. Chez l'être humain, la couleur de la peau, des cheveux et des yeux dépendent principalement de son type et de sa concentration. De nombreux animaux en produisent également, dont les oiseaux (coloration des plumes) et certains protozoaires.
MELAMINE PHOSPHATE
Melamine phosphate decomposes endothermically above 350ºC, acting as a heat sink to cool the polymer.
The released phosphoric acid further reacts with the polymer to form a char and inhibit the release of free radical gasses into the oxygen phase.
Simultaneously, nitrogen species released from the degradation of melamine intumesces the char to further protect the polymer.

CAS: 41583-09-9
MF: C3H9N6O4P
MW: 224.12
EINECS: 255-449-7

Melamine phosphate based halogen free flame retardants are primarily used for glass fiber reinforced polyamide and polyester (e.g. PBT) and can be used as a synergist in many other applications and polymers.

Melamine phosphate is a coordination compound that has been used as an antimicrobial agent and polymer retardant.
Melamine phosphate has been shown to have a Langmuir adsorption isotherm, which is indicative of the ability to form a monolayer on the surface of water droplets.
Melamine phosphate also has an electrochemical impedance spectroscopy (EIS) that can be used for determining the rate constant of its reaction with water vapor.
The rate constants are determined by measuring the change in impedance over time and plotting Melamine phosphate against frequency.
This analytical method is used for determining the concentration and stability of Melamine phosphate in solution and can be applied to other similar compounds.

Melamine phosphate Chemical Properties
Melting point: 120 - 122°C
Density: 1.74
Storage temp.: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Form: Solid
Color: White
Water Solubility: 3.9g/L at 20℃
EPA Substance Registry System: Melamine phosphate (41583-09-9)

Uses
Melamine phosphate is mainly used in PA and PBT, especially PA6, and PA66.
Melamine phosphate can be used in all kinds of injection and extrusion processes and meet all kind of processing demands of polyamide, and glass fiber polyamide.
Melamine phosphate is widely used in fire retardant coatings, flame retardant plastics and other products.
Due to the increasing demand for halogen-free flame retardants in recent years, Melamine phosphate has a new application prospect and a broad market.
Environment-friendly non-halogen flame retardant

Synonyms
Melamine phosphate
20208-95-1
1,3,5-Triazine-2,4,6-triamine, phosphate
41583-09-9
1,3,5-triazine-2,4,6-triamine phosphate
Triazinetriaminephosphate
melamine monophosphate
EINECS 255-449-7
218768-84-4
phosphoric acid;1,3,5-triazine-2,4,6-triamine
DOS5Q2BU94
1,3,5-Triazine-2,4,6-triamine, phosphate (1:1)
1,3,5-Triazine-2,4,6-triamine monophosphate
EINECS 243-601-5
1,3,5-Triazine-2,4,6-triamine, phosphate (1:?)
EC 255-449-7
hate
INTUMESCENTCOMPOUNDKE8000
Melamine Polyphosp
EINECS 260-493-5
UNII-DOS5Q2BU94
C3H6N6.xH3O4P
SCHEMBL73239
C3H6N6.H3O4P
DTXSID80872787
XFZRQAZGUOTJCS-UHFFFAOYSA-N
C3-H6-N6.H3-O4-P
C3-H6-N6.x-H3-O4-P
MELAMINE, PHOSPHATE (1:1)
MFCD00060248
AKOS028108538
AS-15268
CS-0449429
FT-0628188
FT-0742330
F71215
Di(1,3,5-triazine-2,4,6-triamine) phosphate
1,3,5-Triazine-2,4,6-triamine, phosphate (2:1)
MELAMINE PHOSPHATE (MP)
Melamine Phosphate (MP) is a distinguished flame retardant formulation comprising both nitrogen and phosphorus.
Melamine Phosphate (MP) is white powder, has good water resistance, used in intumescent flame retardant systems.
Melamine Phosphate (MP) has a char-forming intumescent mechanism.


CAS Number: 20208-95-1 / 41583-09-9
EC Number: 243-601-5
Molecular Formula: C3H9N6PO4



SYNONYMS:
MPOP, SLFR-7, Melamine-phosphate, MELAMINE PHOSPHATE, Melamine Phosphate(FR-MP), Triazine triamine phosphate, triazine triamine phosphate, INTUMESCENT COMPOUND KE 8000, (56386-64-2) melamine-phosphate, 1,3,5-triazine-2,4,6-triamine phosphate, Flame retardant MP;FR-MP, 1,3,5-triazine-2,4,6-triamine polyphosphate, 1,3,5-Triazine-2,4,6-triamine·phosphoric acid, Melamine phosphoric acid, Phosphoric acid·melamine, INTUMESCENT COMPOUND KE 8000, SLFR-7, 1,3,5-triazine-2,4,6-triamine monophosphate, 1,3,5-Triazine-2,4,6-triamine, phosphate (1:1), MP, SLFR-7, Melamine Phosphate, Melamine Polyphosphate, Melamine phosphoric acid, Phosphoric acid·melamine, INTUMESCENT COMPOUND KE 8000, 1,3,5-triazine-2,4,6-triamine phosphate, 1,3,5-triazine-2,4,6-triamine polyphosphate, 1,3,5-triazine-2,4,6-triamine monophosphate, 1,3,5-Triazine-2,4,6-triamine polyphosphate, 1,3,5-Triazine-2,4,6-triamine·phosphoric acid
triazine triamine phosphate, INTUMESCENT COMPOUND KE 8000, 1,3,5-triazine-2,4,6-triamine phosphate, SLFR-7, MELAMINE PHOSPHATE, (56386-64-2) melamine-phosphate, Melamine Phosphate(FR-MP), 1,3,5-Triazine-2,4,6-triamine, phosphate (1:), melamine polyphosphate (mp), einecs 243-601-5, melamine phosphate (mp), melamine polyphosphate, intumescent compound ke 8000, non-halogen flame-retardant mp, melamine phosphoric acid, melamine polyphosphate (mpp), slfr-7, phosphoric acid•melamine, 1,3,5-Triazine-2,4,6-triamine,phosphate (1:?), 1,3,5-Triazine-2,4,6-triamine,phosphate, Melamine phosphoric acid salt, Melamine phosphate, Melamine orthophosphate, MPP-A, Fyrol MP, Melapur MPH, MPP 2, DMP, Melapur MP, Antiblaze NH, P 7202, MPP-B, Apinon P 7202, Apinon MPP-A, MPP-A (flame retardant), MP 200 (flame retardant), MP 200, EPFR 300A, Apinon MPP-B, Melapur MP 116, MPP 300, 110D, Preniphor EPFR-MPP 300, Budit 312, EPFR-MPP 300, 163183-93-5, 1395056-61-7, melamine polyphosphate (mp) , einecs 243-601-5 , melamine phosphate (mp) , melamine polyphosphate , intumescent compound ke 8000 , non-halogen flame-retardant mp , melamine phosphoric acid , melamine polyphosphate (mpp) , slfr-7 , phosphoric acid•melamine, MP, Melamine Polyphosphate, 1,3,5-Triazine-2,4,6-triamine polyphosphate, 1,3,5-triazine-2,4,6-triamine phosphate (1:1), 1,3,5-triazine-2,4,6-triamine phosphate, 1,3,5-triazine-2,4,6-triamine polyphosphate, INTUMESCENT COMPOUND KE 8000, SLFR-7, 1,3,5-triazine-2,4,6-triamine monophosphate, 1,3,5-Triazine-2,4,6-triamine, phosphate (1:1), Non-halogen flame-retardant MP, 1,3,5-Triazine-2,4,6-triamine•phosphoric acid, Melamine phosphoric acid,Melamine polyphosphate,Melamine phosphate,Melamine orthophosphate, MELAMINE PHOSPHATE, Melamine orthophosphate, Melamine phosphoric acid, Melamine polyphosphate, Non-halogen flame-retardant MP, SLFR-7, 1,3,5-triazine-2,4,6-triamine monophosphate, 1,3,5-triazine-2,4,6-triamine polyphosphate, 1,3,5-Triazine-2,4,6-triamine, phosphate (1:1), 1,3,5-Triazine-2,4,6-triamine•phosphoric acid, INTUMESCENT COMPOUND KE 8000, 1,3,5-Triazine-2,4,6-triamine, phosphate (1:x), Antiblaze NH, Apinon MPP-A, Apinon MPP-B, Apinon P 7202, Budit 312, Budit 341, DMP, EPFR 300A, Melamine phosphate, EPFR-MPP 300, Exflam MPP, Fyrol MP, Melamine orthophosphate, Melamine phosphoric acid salt, Melapur MP, Melapur MP 116, Melapur MPH, MP 200, MP 200 (flame retardant), MPP 2, MPP 300, MPP-A, MPP-A (flame retardant), MPP-B, MPT 11, P 7202, Preniphor EPFR-MPP 300



Melamine Phosphate (MP) is an excellent in tumescent flame retardant.
Melamine Phosphate (MP) is a distinguished flame retardant formulation comprising both nitrogen and phosphorus.
The cooperative interaction between these components contributes to Melamine Phosphate (MP)'s exceptional flame retardancy.


Additionally, Melamine Phosphate (MP) offers the versatility to incorporate a wide range of commonly employed additives, including antioxidants, UV absorbers, light stabilizers, plasticizers, antistatic agents, fillers, impact modifiers, colorants, and others.
Melamine Phosphate (MP) is a white powder, non-toxic, odourless,insoluble in water and most organic solvents.


Melamine Phosphate (MP) is an invaluable compound extensively employed in the research a diverse array of diseases.
Recognized for its remarkable antimicrobial attributes, Melamine Phosphate (MP) exhibits considerable promise in studying pernicious bacterial infections.
Furthermore,Melamine Phosphate (MP)'s potential in studying inflammation and fostering expedited wound healing has been thoroughly investigated.


Melamine Phosphate (MP) is an excellent flame retardant; It can be applied to polyolefin, linear polyester, polyamide, some thermoplastics, rubber, paint, latex, paper and textiles, etc.
Melamine Phosphate (MP) is a bioactive compound, used for the research of diverse ailments like osteoporosand associated skeletal irregularities.


Melamine Phosphate (MP) is halogen-free nitrogen-phosphorus Flame Retardant.
Melamine Phosphate (MP) is white powder, has good water resistance, used in intumescent flame retardant systems.
Melamine Phosphate (MP) has a char-forming intumescent mechanism.


Melamine Phosphate (MP)'s nitrogen is from melamine (triazine-based).
Melamine Phosphate (MP) is a melamine phosphate grade.
Melamine Phosphate (MP) exhibits excellent flame retardance.


Melamine Phosphate (MP) shows good compatibility with polyolefin, linear polyester, polyamide, thermosetting resins and rubber.
Melamine Phosphate (MP) is a non-halogenated flame retardant based on Melamine Phosphate (CAS 41583-09-9).



USES and APPLICATIONS of MELAMINE PHOSPHATE (MP):
Melamine Phosphate (MP) can be applied to polyolefin, linear polyester, polyamide, some thermosetting resins, rubber, paint, latex, paper and textiles and so on.
Melamine Phosphate (MP) is used environmental protection type non-halogen flame retardant.


Melamine Phosphate (MP) is widely applicable to various synthetic resins, such as polyethylene, polypropylene, polystyrene resin, polycarbonate, polyurethane, EVA, thermoplastic elastomer, etc.
Melamine Phosphate (MP) is mainly used in intumescent flame retardant systems for paints and polymers, combining both the melamine and catalyst functionality.


Other applications of Melamine Phosphate (MP) are in thermosets, both unsaturated polyester and epoxies, and in textile treatment.
In self-charring materials such as cellulose or epoxy, Melamine Phosphate (MP) can be used as such without addition of other flame retardants.
Melamine Phosphate (MP) uses and applications include: Flame retardant for plastics, polyolefins, polyester, rubbers, pigmented coatings, latex intumescent coating formulations, paper, textiles; catalyst in intumescent systems; intumescent paintmastic ingredient


Melamine Phosphate (MP) is mainly used in intumescent flame retardant systems for paints and polymers, combining both the melamine and catalyst functionality.
Other applications of Melamine Phosphate (MP) are in thermosets, both unsaturated polyester and epoxies, and in textile treatment.


In self-charring materials such as cellulose or epoxy, FR-Melamine Phosphate (MP)can be used as such without addition of other flame retardants.
Melamine Phosphate (MP) is used environment-friendly non-halogen flame retardant
Melamine Phosphate (MP) is applied to Tibia polyolefin resin,Cables,electrical appliances,vehicles,construction materials and interiorof the halogen-free flame retardant engineering plastics,etc.


Melamine Phosphate (MP) is widely used in nylon (PolyAmide, PA), TPU, PBT, PET, EVA.
Melamine Phosphate (MP) is mainly used in intumescent flame retardant systems for paints and polymers,combining both the melamine and catalyst functionality.


Melamine Phosphate (MP) is an excellent in tumescent Flame Retardant; it can be applied to polyolefin, linear polyester, polyamide, some thermosetting resins, rubber, paint, latex, paper and textiles and so on.
Melamine Phosphate (MP) is used Flame retardant or synergic agent for polyolefins, elastomers, PU, Epoxy and intumescent fire-retardant coatings.


Melamine Phosphate (MP) is a bioactive compound, used for the research of diverse ailments like osteoporosand associated skeletal irregularities.
Melamine Phosphate (MP) uses and applications include: Flame retardant for plastics, polyolefins, polyester, rubbers, pigmented coatings, latex intumescent coating formulations, paper, textiles; catalyst in intumescent systems; intumescent paintmastic ingredient
Melamine Phosphate (MP) can be applied to polyolefins, linear polyester, polyamide, some thermosetting resins, rubber, paint, latex, paper, and textiles.



KEY FEATURES OF MELAMINE PHOSPHATE (MP):
*No hazard classification or labelling
*Flame Retardant acting both in gas and solid phase
*Effective as such or in combination with other flame retardants
*Nearly insoluble in water or solvents



PHYSICAL PROPERTIES OF MELAMINE PHOSPHATE (MP):
- Melamine Phosphate (MP) is a white powder, non-toxic, odourless,insoluble in water and most organic solvents.
- Thermal stability, FR-Melamine Phosphate (MP)is the preferred compound in terms of highest processing stability.
- Flame retardancy, P-N synergistic effect, The best matching of its decomposition temperature and the coating decomposition temperature, FR-Melamine Phosphate (MP)and its derivatives offers excellent flame retardancy and increase the carbon layer quantity.



BENEFITS OF MELAMINE PHOSPHATE (MP):
*Excellent intumescent flame retardant



INDUSTRY OF MELAMINE PHOSPHATE (MP):
*Textiles ,
*Plastics ,
*Rubber



FUNCTIONS OF MELAMINE PHOSPHATE (MP):
*Catalyst ,
*Flame Retardant



FEATURE OF MELAMINE PHOSPHATE (MP):
1. Thermal stability, Melamine Phosphate (MP) is the preferred compound in terms of highest processing stability.
2. Flame retardancy, P-N synergistic effect, The best matching of its decomposition temperature and the coating decomposition temperature, Melamine Phosphate (MP) and its derivatives offers excellent flame retardancy and increase the carbon layer quantity.



PHYSICAL and CHEMICAL PROPERTIES of MELAMINE PHOSPHATE (MP):
Chemical Formula: C3H9N6PO4
Molecular Weight: 224.12 g/mol
EINECS No.: 243-601-5
CAS No.: 20208-95-1
Appearance: White powder
N content (%): 42 to 44
P content (%): 12 to 14
Water content (%): ≤ 0.3
pH value (10g/L): 2 to 4
Particle size (µm): D50 ≤ 2.5
Solubility (20°C) (g/L): ≤ 3

Melting point: 120 - 122°C
Density: 1.74 g/cm³
Storage Temp.: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Form: Solid
Color: White
Water Solubility: 3.9 g/L at 20°C
EPA Substance Registry System: 1,3,5-Triazine-2,4,6-triamine, phosphate (41583-09-9)
Odour: Odourless
Bulk Density (Kg/m³): ≈ 300-500
Moisture content: < 0.5%
Water solubility (g/100cc): ≈ 0.35 (at 20°C)
pH (saturated solution): 2.5 – 3.5

Thermal stability (5% weight loss): ≈ 280°C (TGA, 10°C/min. N2)
D50 (µm): < 7
Boiling Point: 557.5°C at 760 mmHg
Flash Point: 325.3°C
Exact Mass: 224.042282
PSA: 204.30000
Vapour Pressure: 1.82E-12 mmHg at 25°C
InChI: InChI=1/C3H6N6.H3O4P/c4-1-7-2(5)9-3(6)8-1;1-5(2,3)4/h(H6,4,5,6,7,8,9);(H3,1,2,3,4)
InChI Key: XFZRQAZGUOTJCS-UHFFFAOYSA-N
SMILES: O=P(O)(O)O.N=1C(=NC(=NC1N)N)N
Phenol content (ppm): ≤ 500
TPP (%): ≤ 3.0
Viscosity (mpas at 25ºC): 500-800
Acid Value (%): ≤ 0.10

Identifiers:
CAS: 20208-95-1, 41583-09-9, 56386-64-2
EINECS: 243-601-5, 255-449-7
InChI: InChI=1/C3H6N6.H3O4P/c4-1-7-2(5)9-3(6)8-1;1-5(2,3)4/h(H6,4,5,6,7,8,9);(H3,1,2,3,4)/p-3
InChI Key: XFZRQAZGUOTJCS-UHFFFAOYSA-N
SMILES: O=P(O)(O)O.N=1C(=NC(=NC1N)N)N
Molecular Formula: C3H6N6O4P
Molecular Weight: 224.12 g/mol
Exact Mass: 224.04200 g/mol
EC Number: 255-449-7
UNII: DOS5Q2BU94
DSSTox ID: DTXSID9068328, DTXSID80872787, DTXSID40872788

Characteristics:
PSA: 204.30000
XLogP3: -0.56680
Appearance: White, crystalline powder
Density: 1.74 g/cm³
Melting Point: 354ºC
Boiling Point: 557.5ºC at 760 mmHg
Flash Point: 325.3ºC
Vapour Pressure: 1.82E-12 mmHg at 25°C
Identifiers:
InChI: InChI=1/C3H6N6.H3O4P/c4-1-7-2(5)9-3(6)8-1;1-5(2,3)4/h(H6,4,5,6,7,8,9);(H3,1,2,3,4)/p-3
CAS Registry Number: 20208-95-1
EINECS: 243-601-5



FIRST AID MEASURES of MELAMINE PHOSPHATE (MP):
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of MELAMINE PHOSPHATE (MP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of MELAMINE PHOSPHATE (MP):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MELAMINE PHOSPHATE (MP):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MELAMINE PHOSPHATE (MP):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of MELAMINE PHOSPHATE (MP):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


MELAMINE POLYPHOSPHATE

Melamine polyphosphate is a chemical compound with the molecular formula (C3H6N6)x(HPO3)y.
Melamine polyphosphate is a polymer consisting of repeating units of melamine (C3H6N6) and phosphoric acid (HPO3) linked together.
The value of 'x' and 'y' in the formula can vary depending on the degree of polymerization.

CAS Number: 218768-84-4




APPLICATIONS


Melamine polyphosphate is extensively used in the plastics industry as a flame retardant additive for polymeric materials.
Melamine polyphosphate is incorporated into polypropylene and polyethylene to enhance their fire resistance and meet stringent safety standards.

Melamine polyphosphate finds application in the production of flame-retardant cables and wires, ensuring electrical safety.
Melamine polyphosphate is used in the formulation of fire-resistant coatings and paints, providing an additional layer of protection to surfaces.

Melamine polyphosphate is employed in the manufacturing of flame-retardant textiles and fabrics used in upholstery, curtains, and protective clothing.
Melamine polyphosphate is added to polyurethane foams to improve their fire performance in applications such as furniture, mattresses, and automotive seating.

Melamine polyphosphate is used in the construction industry for fireproofing materials like gypsum boards and insulation products.
Melamine polyphosphate finds application in the production of fire-resistant adhesives, ensuring the safety of bonded materials in various industries.
Melamine polyphosphate is used in the automotive sector for fire protection in components such as interior trims, dashboards, and wiring systems.
Melamine polyphosphate is employed in the manufacturing of fire-retardant coatings for steel structures, providing structural fire resistance.

Melamine polyphosphate finds application in the production of fire-resistant composites used in aerospace and defense industries for structural integrity.
Melamine polyphosphate is used in the formulation of fire-resistant sealants and caulks, ensuring fire containment in building construction.
Melamine polyphosphate is employed in the production of fire-retardant laminates and decorative surfaces for interior design and architecture.

Melamine polyphosphate is added to thermosetting resins, such as epoxy, to enhance their fire resistance in electrical and electronic applications.
Melamine polyphosphate finds application in the production of fire-resistant foams used in insulation panels for buildings and refrigeration equipment.
Melamine polyphosphate is used in the formulation of fire-resistant coatings for wood and furniture, reducing the flammability of these materials.
Melamine polyphosphate is employed in the production of fire-resistant panels used in transport vehicles to ensure passenger safety.

Melamine polyphosphate is added to polymer compounds used in electrical enclosures and switchgear to minimize the risk of fire.
Melamine polyphosphate finds application in the production of fire-resistant molded parts and components for industrial equipment.
Melamine polyphosphate is used in the formulation of fire-retardant masterbatches, which are then incorporated into various plastic products.
Melamine polyphosphate is employed in the production of fire-resistant films and membranes used in the construction of air barriers and vapor retarders.

Melamine polyphosphate is used in the formulation of fire-resistant coatings for structural steel, enhancing its fire performance.
Melamine polyphosphate finds application in the production of fire-resistant gaskets, seals, and O-rings for industrial applications.
Melamine polyphosphate is employed in the formulation of fire-retardant polymeric additives used in 3D printing materials.

Melamine polyphosphate is used in the production of fire-resistant foams and textiles for military and protective gear applications.
Melamine polyphosphate finds application in the production of fire-resistant coatings for electrical transformers, ensuring their safety during operation.
Melamine polyphosphate is used in the formulation of fire-resistant resins and compounds for the manufacturing of printed circuit boards (PCBs).
Melamine polyphosphate is employed in the production of fire-resistant thermoplastic elastomers used in automotive and industrial applications.

Melamine polyphosphate is added to polymeric materials used in the construction of air ducts and ventilation systems to improve fire safety.
Melamine polyphosphate finds application in the formulation of fire-resistant thermosetting laminates for high-performance applications.
Melamine polyphosphate is used in the production of fire-resistant films and sheets for packaging materials, protecting contents from fire hazards.
Melamine polyphosphate is employed in the formulation of fire-resistant coatings for wooden furniture, reducing the risk of ignition and flame spread.
Melamine polyphosphate finds application in the production of fire-resistant synthetic fibers used in carpets, upholstery, and textiles for public spaces.
Melamine polyphosphate is added to foam mattresses and bedding products to enhance their fire resistance and meet flammability standards.

Melamine polyphosphate is used in the production of fire-resistant filters and membranes for industrial filtration applications.
Melamine polyphosphate is employed in the formulation of fire-resistant paints and varnishes for wooden structures, providing additional fire protection.
Melamine polyphosphate finds application in the production of fire-resistant wire and cable jackets, ensuring electrical safety in various industries.
Melamine polyphosphate is added to thermoplastic materials used in electronic enclosures to minimize fire risks and protect sensitive components.
Melamine polyphosphate is used in the formulation of fire-resistant coatings for steel structures in the construction of bridges, tunnels, and industrial facilities.
Melamine polyphosphate finds application in the production of fire-resistant foams used in insulation panels for appliances and HVAC systems.

Melamine polyphosphate is employed in the formulation of fire-resistant paints for commercial and public buildings, improving fire safety.
Melamine polyphosphate is added to resin-based composites used in the production of fire-resistant doors and partitions for enhanced building fire protection.
Melamine polyphosphate finds application in the production of fire-resistant textiles and fabrics used in curtains, theater drapes, and stage backdrops.
Melamine polyphosphate is used in the formulation of fire-resistant coatings for wooden decks and outdoor structures, reducing fire hazards.
Melamine polyphosphate is employed in the production of fire-resistant seals and gaskets for applications where high-temperature resistance is required.
Melamine polyphosphate finds application in the formulation of fire-resistant adhesives and sealants for construction and industrial bonding.

Melamine polyphosphate is added to thermoplastic materials used in the production of fire-resistant pipes and plumbing systems.
Melamine polyphosphate is used in the formulation of fire-resistant molding compounds for the production of electrical connectors and insulating components.
Melamine polyphosphate finds application in the production of fire-resistant additives for intumescent coatings used in passive fire protection systems.
Melamine polyphosphate is employed in the formulation of fire-resistant mortars and sealants for the installation of fire-rated structures.


Some of its primary applications include:

Plastics:
Melamine polyphosphate is widely used in plastics to improve their fire resistance.
Melamine polyphosphate can be incorporated into polypropylene, polyethylene, polystyrene, and other plastic materials to enhance their flame retardant properties.

Polymers:
Melamine polyphosphate is utilized in polymer formulations to increase their resistance to fire.
Melamine polyphosphate is commonly added to polyurethane foams, epoxy resins, and other polymer systems to improve their flame retardancy.

Electrical and Electronics:
Melamine polyphosphate finds extensive use in the electrical and electronics industry.
Melamine polyphosphate is added to cables, wires, connectors, and electronic components to enhance their fire safety and meet regulatory requirements.

Textiles:
Melamine polyphosphate is employed in the textile industry to impart flame retardancy to fabrics.
Melamine polyphosphate can be applied to textiles through various methods such as coating, padding, or incorporation into fibers, providing fire-resistant properties.

Coatings and Paints:
Melamine polyphosphate is used in coatings and paints to increase their fire resistance.
Melamine polyphosphate can be added to water-based or solvent-based coatings to improve their flame retardant capabilities.

Adhesives:
Melamine polyphosphate is incorporated into adhesive formulations to enhance their fire performance.
Melamine polyphosphate is commonly used in construction adhesives, laminating adhesives, and other adhesive products where fire safety is a concern.

Automotive:
Melamine polyphosphate is utilized in the automotive industry for fire protection.
Melamine polyphosphate is added to various automotive components and materials such as interior trim, seating, wiring, and engine parts to reduce flammability and improve safety.

Building Materials:
Melamine polyphosphate is employed in the production of fire-resistant building materials.
Melamine polyphosphate can be used in gypsum boards, insulation materials, sealants, and other construction products to enhance their fire performance.

Foam Insulation:
Melamine polyphosphate is utilized in foam insulation materials to increase their resistance to fire.
Melamine polyphosphate helps to prevent the spread of flames and reduce the release of toxic gases during a fire event.

Transportation:
Melamine polyphosphate is used in the transportation industry for fire protection.
Melamine polyphosphate is added to materials and components used in airplanes, trains, ships, and other transportation vehicles to meet stringent fire safety regulations.


Melamine polyphosphate is a white, crystalline solid with a fine powder texture.
Melamine polyphosphate has a molecular weight that can vary depending on the degree of polymerization.

Melamine polyphosphate is odorless and non-toxic.
Melamine polyphosphate is insoluble in water and most organic solvents.

Melamine polyphosphate exhibits good thermal stability, allowing it to withstand high processing temperatures.
Melamine polyphosphate is highly effective as a flame retardant additive.
Melamine polyphosphate forms a protective char layer when exposed to flames, inhibiting the spread of fire.
Melamine polyphosphate has low smoke emission properties.

Melamine polyphosphate is widely used in the plastics and polymer industry for fire-resistant applications.
The compound acts as a heat sink, absorbing and dissipating heat energy during combustion.
Melamine polyphosphate releases water vapor when exposed to fire, diluting flammable gases.

Melamine polyphosphate is considered to be environmentally friendly.
Melamine polyphosphate is a non-halogenated flame retardant, making it a preferred alternative to halogen-based additives.
The compound is compatible with various polymer matrices, including polypropylene and polyethylene.
Melamine polyphosphate has minimal impact on the physical and mechanical properties of the materials it is incorporated into.
Melamine polyphosphate exhibits excellent flame-retardant properties at relatively low loading levels.

Melamine polyphosphate provides long-lasting fire protection due to its ability to form a stable char layer.
The compound is commonly used in electrical and electronic applications to enhance fire safety.
Melamine polyphosphate is suitable for use in automotive components, textiles, coatings, and adhesives.

Melamine polyphosphate has good thermal stability and does not decompose easily.
Melamine polyphosphate is resistant to leaching and migration, ensuring the longevity of its flame-retardant properties.
Melamine polyphosphate can be easily dispersed and incorporated into various formulations.
Melamine polyphosphate is compatible with different processing techniques, including extrusion and injection molding.

Melamine polyphosphate is often used in combination with other flame retardants for synergistic effects.
Melamine polyphosphate meets various industry standards and regulations for flame retardancy.



DESCRIPTION


Melamine polyphosphate is a chemical compound with the molecular formula (C3H6N6)x(HPO3)y.
Melamine polyphosphate is a polymer consisting of repeating units of melamine (C3H6N6) and phosphoric acid (HPO3) linked together.
The value of 'x' and 'y' in the formula can vary depending on the degree of polymerization.

Melamine polyphosphate is a flame retardant additive that is widely used in various applications, especially in the field of plastics and polymers.
Melamine polyphosphate offers excellent fire resistance properties and is known for its ability to inhibit or delay the spread of flames.
Melamine polyphosphate is considered to be environmentally friendly and is commonly used as a substitute for other halogenated flame retardants due to its lower toxicity and improved performance.

Melamine polyphosphate is insoluble in water and most organic solvents.
Melamine polyphosphate is stable under normal conditions and exhibits good thermal stability, allowing it to withstand high processing temperatures during the manufacturing of flame-retardant materials.

Melamine polyphosphate can be incorporated into a wide range of materials, including polypropylene, polyethylene, polyurethane, epoxy resins, and more, to enhance their fire resistance.
Melamine polyphosphate forms a protective char layer when exposed to flames, which acts as a barrier, preventing the spread of fire and heat transfer.
Melamine polyphosphate is widely used in the production of electrical and electronic components, automotive parts, textiles, coatings, adhesives, and other products where fire safety is a concern.

Melamine polyphosphate works by releasing water vapor and diluting flammable gases when exposed to fire, thus reducing the overall flammability of the material.
Additionally, Melamine polyphosphate acts as a heat sink, absorbing and dissipating heat energy generated during combustion.
Melamine polyphosphate is known for its high efficiency in flame retardancy, low smoke emission, and minimal impact on the physical and mechanical properties of the materials it is incorporated into.



PROPERTIES


Chemical Formula: (C3H9N6PO6)n
Molecular Weight: Variable, depending on the polymerization degree
Appearance: White, fine powder
Odor: Odorless
Melting Point: Decomposes before melting
Solubility: Insoluble in water
Density: Varies depending on the grade and formulation
pH: Neutral to slightly acidic
Stability: Stable under normal conditions
Flammability: Non-flammable
Toxicity: Low toxicity, but proper handling and safety precautions should be followed
Decomposition Temperature: Typically above 300°C (572°F)
Decomposition Products: Melamine, phosphoric acid, and other breakdown products
Compatibility: Compatible with various polymers and additives
Thermal Stability: Provides thermal stability to the materials it is added to
Flame Retardancy: Exhibits excellent flame retardant properties, reducing the flammability of materials
Smoke Suppression: Helps suppress smoke generation during a fire event
Char Formation: Promotes the formation of a stable char layer, which acts as a barrier against heat and flames
Synergistic Effects: Can enhance the flame retardant performance when combined with other additives
Environmental Impact: Considered environmentally friendly and complies with various regulations
Electrical Properties: Does not significantly affect electrical conductivity of materials



FIRST AID


Inhalation:

Move the affected person to fresh air and ensure they are in a well-ventilated area.
If breathing difficulties persist, seek medical attention immediately.
Administer oxygen if necessary and perform artificial respiration if the person is not breathing.


Skin Contact:

Remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes.
If irritation or redness occurs, seek medical advice.
Wash contaminated clothing before reusing.


Eye Contact:

Rinse the eyes gently with water for at least 15 minutes, ensuring the eyelids are held open to facilitate thorough flushing.
Seek immediate medical attention, even if no symptoms are present.
Remove contact lenses, if applicable, after rinsing for 5 minutes.


Ingestion:

Rinse the mouth thoroughly and provide the affected person with water to drink in small sips.
Do not induce vomiting unless instructed to do so by medical personnel.
Seek immediate medical attention and provide them with as much information as possible about the ingested substance.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a dust mask, to minimize the risk of exposure during handling.

Ventilation:
Ensure good ventilation in the working area to prevent the accumulation of dust or vapors.
Use local exhaust ventilation if necessary.

Avoid Inhalation:
Avoid breathing in dust or vapors.
If handling in powdered form, take precautions to prevent dust generation, such as using dust collection systems or wet methods.

Avoid Skin Contact:
Avoid direct skin contact by wearing suitable protective gloves and clothing.
In case of contact, promptly wash the affected area with water and soap.

Eye Protection:
Wear safety goggles or a face shield to protect the eyes from potential splashes or contact with the substance.

Handling Equipment:
Use appropriate handling equipment, such as scoops or shovels, to transfer the material.
Avoid generating dust during handling and transfer operations.

Static Electricity:
Take precautions to prevent the buildup of static electricity, as it can increase the risk of dust ignition.
Grounding equipment and containers can help dissipate static charges.

No Smoking or Open Flames:
Prohibit smoking and the presence of open flames in the handling area, as Melamine polyphosphate is not flammable but can release flammable decomposition products under certain conditions.



Storage:


Store in a Cool, Dry Place:
Keep Melamine polyphosphate in a cool, dry, well-ventilated area, away from direct sunlight and sources of heat or ignition.

Temperature Control:
Maintain stable temperatures within the recommended storage range to preserve the integrity of the material.

Avoid Moisture:
Protect the substance from excessive moisture or humidity, as it can affect its performance and quality.
Use moisture-proof packaging or containers if necessary.

Keep Containers Tightly Sealed:
Ensure that containers are tightly sealed to prevent exposure to air or moisture, which can lead to clumping or degradation.

Separate from Incompatible Materials:
Store Melamine polyphosphate away from incompatible substances, such as oxidizing agents or strong acids, to prevent chemical reactions or contamination.

Storage Stability:
The material is generally stable under normal storage conditions.
However, it is recommended to follow the manufacturer's guidelines for the maximum recommended storage period.

Proper Labeling:
Clearly label containers with the product name, batch/lot number, date of manufacture, and any relevant hazard information for easy identification and traceability.

Secure Storage:
Ensure proper storage practices to prevent unauthorized access or accidental spillage.



SYNONYMS


Melamine phosphate
Melamine polyphosphoric acid
MPP
MPP flame retardant
Melamine pyrophosphate
Melamine polyphosphonate
Melamine polyphosphate resin
Melamine phosphonate
Melamine phosphoric acid
N-methylol melamine phosphate
Melamine ammonium polyphosphate
Melamine ammonium phosphate
Melamine ammonium pyrophosphate
Melamine ammonium phosphonate
Melamine ammonium phosphoric acid
Melamine ammonium polyphosphonate
Melamine ammonium polyphosphoric acid
Melamine ammonium polyphosphate resin
Melamine ammonium phosphonate resin
Melamine ammonium phosphoric acid resin
MAP-MP
MAPP
MAP
MPA
MPP-NH4
Melamine phosphoric acid resin
Melamine polyphosphoric acid resin
Melamine ammonium phosphate resin
MPA resin
MPP-NH4 resin
Melamine ammonium polyphosphate-based flame retardant
Melamine phosphate-based flame retardant
Melamine polyphosphoric acid-based flame retardant
MPP flame retardant resin
MAP flame retardant
Melamine ammonium polyphosphate flame retardant
Melamine phosphonate flame retardant
Melamine polyphosphonate-based flame retardant
Melamine phosphoric acid-based flame retardant
MPA-based flame retardant
Melamine ammonium phosphate-based fire retardant
Melamine polyphosphoric acid-based fire retardant
Melamine phosphonate-based fire retardant
Melamine polyphosphonate flame retardant resin
Melamine phosphoric acid flame retardant resin
MAP flame retardant resin
Melamine ammonium polyphosphate-based fire-resistant additive
Melamine phosphonate-based fire-resistant additive
Melamine polyphosphonate fire-resistant additive
Melamine phosphoric acid-based fire-resistant additive
Melamine polyphosphate FR
Melamine phosphate FR
Melamine ammonium phosphate FR
MAP-MP FR
MAPP FR
Melamine polyphosphoric acid FR
Melamine phosphonate FR
Melamine polyphosphonate FR
Melamine phosphoric acid-based FR
Melamine polyphosphoric acid-based FR
Melamine ammonium phosphate-based fire retardant
MAP-MP-based fire retardant
MAPP-based fire retardant
Melamine polyphosphoric acid-based fire retardant
Melamine phosphonate-based fire retardant
Melamine polyphosphonate-based fire retardant
Melamine ammonium phosphate-based flame inhibitor
Melamine polyphosphoric acid-based flame inhibitor
Melamine phosphonate-based flame inhibitor
Melamine polyphosphonate-based flame inhibitor
Melamine phosphoric acid-based flame inhibitor
MAP-MP-based flame inhibitor
MAPP-based flame inhibitor
Melamine ammonium phosphate-based flame suppressant
Melamine polyphosphoric acid-based flame suppressant
MELAMINE POLYPHOSPHATE (MPP)
Melamine polyphosphate (MPP) acts as a flame retardant.
Melamine polyphosphate (MPP) is suitable for making polystyrene flame retardant, instead of polybrominated diphenyl ether.
Melamine polyphosphate (MPP) is especially suitable for flame retardant glass fibre reinforced PA66.


CAS Number: 218768-84-4
EC Number: 243-601-5
MDL Number: MFCD00060248
Molecular formula: (C3H8N6)m(HPO3)n
Formula: (C3H8N6)n(HPO3)m; C3H7N6O3P)n;
1,3,5-triazine-2,4,6-triamine, polyphosphate;



SYNONYMS:
FR-NP, Melapur 200, Melapur M 200, Melamine Polyphosphate, Fr-Np Melamine Polyphosphate, Melamine Polyphosphate(FR-NP), SLFR-7, Einecs 243-601-5, Melamine polyphosphate, MelaMine phosphate (MP), Phosphoric acid•melamine, Melamine phosphoric acid, MelaMine polyphosphate (MP), Melamine polyphosphate,>99%, INTUMESCENT COMPOUND KE 8000, MelaMine polyphosphate (MPP)



Melamine polyphosphate (MPP) is a highly efficient nitrogen-phosphorus intumescent flame retardant.
Melamine polyphosphate (MPP) has the advantages of high thermal stability, low water solubility, no precipitation, and excellent flame retardant properties.
Melamine polyphosphate (MPP) acts as a flame retardant.


Melamine polyphosphate (MPP) is halogen-free and low poison, meet European Environmental Protection requirements.
Melamine polyphosphate (MPP) possesses good heat stability, decomposition temperature=330°C.
Melamine polyphosphate (MPP) is an expandable flame retardant, which can be used as a flame retardant alone or in combination with other flame retardants.


Melamine polyphosphate (MPP) is suitable for fire-resistant coatings, PBT, PET, epoxy resins, etc., especially suitable for flame retardant fiberglass reinforced PA66, and
Melamine polyphosphate (MPP) can meet the processing requirements of most engineering plastics.


Melamine polyphosphate (MPP) is halogen-free nitrogen-phosphorus intumescent flame retardant, suitable for processing substrates with high temperature requirements.
Melamine polyphosphate (MPP)'s nitrogen is from melamine (triazine-based).


Melamine polyphosphate (MPP) is suitable for fireproof coating, PBT, PET, epoxy resins, polyamide, etc.
Melamine polyphosphate (MPP) is especially suitable for flame retardant glass fibre reinforced PA66.
Melamine polyphosphate (MPP) provides strong thermal decomposition and great flame retardant effect.


Melamine polyphosphate (MPP), is a melamine based halogen free flame retardant for glass fiber reinforced polyamide 66 and suitable to use in thermosetting, thermoplastic formula, especially PUR and also be widely used in PBT, PET, PA
Melamine polyphosphate (MPP) is a halogen-free flame retardant based on Nitrogen and Phosphorus, with excellent process properties, high thermal stability, low water solubility, low immigration.


Melamine polyphosphate (MPP) is an effective flame retardant used in combination with pentaerythritol phosphate in thermoplastic polyester.
Melamine polyphosphate (MPP) is suitable for making polystyrene flame retardant, instead of polybrominated diphenyl ether.
Melamine polyphosphate (MPP) is suitable for making rubber (butadiene, nitrile, polypropylene elastic) nylon 6/6, epoxy resin, hard polyurethane foam flame retardant.


Melamine polyphosphate (MPP) is an efficient nitrogen-phosphorus intumescent flame retardant.
Melamine polyphosphate (MPP) has the advantages of high thermal stability, low water solubility and excellent flame retardant properties.
Melamine polyphosphate (MPP) is halogen-free flame retardant, especially used in the glass fiber reinforced PA66.


Melamine polyphosphate (MPP) has good thermal stability, decomposition temperature >350°C.
Melamine polyphosphate is a halogen-free flame retardant, and have very high thermal stability.
The decomposition temperature of Melamine polyphosphate (MPP) is ≥375℃.


Melamine polyphosphate (MPP) is an efficient nitrogen-phosphorus intumescent flame retardant.
Melamine polyphosphate (MPP) has the advantages of high thermal stability, low water solubility, excellent flame retardant performance, etc.
Melamine polyphosphate (MPP) is an environmental-friendly halogen-free flame retardants.



USES and APPLICATIONS of MELAMINE POLYPHOSPHATE (MPP):
Melamine polyphosphate (MPP) can be used for flame retardant modification/post -treatment of high temperature nylon, glass fiber reinforced nylon 6/nylon 66/PBT, polyurethane and fiber fabrics.
Melamine polyphosphate (MPP) can also be used in combination with other materials to obtain better flame retardant effect.


Melamine polyphosphate (MPP) may be widely applied in thermoplastic and thermosetting plastics, and rubber, fiber and so on.
Melamine polyphosphate (MPP) is also specially used for glass fiber reinforced polyamide 66.
Melamine polyphosphate (MPP) is used sSpecially used for glass-fiber reinforced nylon


Melamine polyphosphate (MPP) is widely applied to thermoplastics, thermosetting plastics, rubber, and fiber
Melamine polyphosphate (MPP) is mainly used in PA and PBT, especially PA6, and PA66.
Melamine polyphosphate (MPP) can be used in all kinds of injection and extrusion processes and meet all kind of processing demands of polyamide, and glass fiber polyamide.


Melamine polyphosphate (MPP) is mainly used in polyamide and PBT, especially PA6, PA66, glass fiber-reinforced PA6, PA66.
Nylon containing Melamine polyphosphate (MPP) can be used in all kind of injection and extrusion process and meet all kind of processing demands...
Melamine polyphosphate (MPP) is mainly used in polyamide and PBT, especially PA6, PA66, glass fiber-reinforced PA6, PA66.


Nylon containing Melamine Polyphosphate(MPP) can be used in all kind of injection and extrusion process as well as meet all kind of processing demands of polyamide, glass fiber polyamide.
Melamine polyphosphate (MPP) is used environmental protection type non-halogen flame retardant


Melamine polyphosphate (MPP) can be used as catalyst and foaming agent in fireproof coating, and its performance is slightly better than that of common ammonium polyphosphate.
Melamine polyphosphate (MPP) can be applied in vinyl acetate copolymer such as sharing with cyclic urea-formaldehyde (coking agent) in polyolefin demonstrating highly effective expansion flame retardant effect.


Melamine polyphosphate (MPP) is mainly used for flame retardant in glass fiber reinforced nylon, polyurethane and fiber fabrics.
Melamine polyphosphate (MPP) is mainly used in PA and PBT, especially PA6, PA66. It can be used in all kind of injection and extrusion process and meet all kind of processing demands of polyamide, glass fiber polyamide.


Melamine polyphosphate (MPP) is used FR-NP, exists in white powder, is a kind of expanded flame retardant,which not only is used as flame retardant but also is used together with other flame retardants,especially used in the glass fiber reinforced PA66,and can meet the process requests of most engineering plastics.


Melamine polyphosphate (MPP) is used specially for glass fiber reinforced polyamide 66
Melamine polyphosphate (MPP) can be used as a catalyst and foaming agent in the fire process, and its performance is slightly better than that of ammonium polyphosphate.


Melamine polyphosphate (MPP) can be applied in vinyl acetate copolymer such as combined with cyclic urea-formaldehyde (coking agent) in polyolefin shows very good flame retardant effect.
Melamine polyphosphate (MPP) is a good synthetic flame retardant used in combination with pentaerythritol phosphate in thermoplastic polyester.


Melamine polyphosphate (MPP) is necessary to make polystyrene flame retardant, instead of polybrominated diphenyl ether.
Melamine polyphosphate (MPP) is suitable for making rubber (butadiene, nitrile, polypropylene elastic) nylon 6/6, epoxy resin, polyurethane foam as flame retardant.


Melamine polyphosphate (MPP) is mainly used in polyamide and PBT, especially PA6, PA66, glass fiber-reinforced PA6, PA66.
Nylon containing NP-100 can be used in all kind of injection and extrusion process and meet all kind of processing demands of polyamide, glass fiber polyamide.


Melamine polyphosphate (MPP) is mainly used in polyamide, especially PA6, PA66, glass fiber-reinforced PA6, PA66 and PBT, etc.
Nylon containing Melamine polyphosphate (MPP) can be used in all kinds of injection and extrusion process and meet all kinds of processing demands of polyamide and glass fiber polyamide.


Melamine polyphosphate (MPP) is used catalyst and foam
Melamine polyphosphate (MPP) is used in ethylene-vinyl acetate copolymer and such as Cyclic urea-formaldehyde resin(carbon) have good expand effect in polyolefin.


Melamine polyphosphate (MPP) is very flame retardant with pentaerythritol phosphate in thermoplastic resin.
Melamine polyphosphate (MPP) is used in polystyrene can replace polybrominate diphenyl.
Melamine polyphosphate (MPP) is used Rubber(butylbenzene, butyronitrile), PP,PA6/6,Epoxy resin, Polyurethane foam,


Melamine polyphosphate (MPP) is used Silicone molding(with porous graphite).
Melamine polyphosphate (MPP) has a very high thermal stability whose decomposition temperature is more than360 ℃.
Melamine polyphosphate (MPP) is widely used in thermo plastics and thermo setting plastics, rubber, fiber and other products.


What’s more, Melamine polyphosphate (MPP) has very good flame retardance effect when using in glass fiber reinforced nylon66.
Melamine polyphosphate (MPP) is 15541-60-3, and its molecular formula is C3H10N6O7P2, is a chemical intermediate.
Melamine polyphosphate (MPP) is mainly used for flame retardant in glass fiber reinforced nylon, polyurethane and fiber fabrics.


Melamine polyphosphate (MPP) can be widely applied in thermoplastic and thermosetting plastics, and rubber, fiber, and so on.
Melamine polyphosphate (MPP) is used specially for glass fiber reinforced polyamide 66.
Melamine polyphosphate (MPP) can use in the fire-retardant coating for .



BENEFITS AND FEATURES OF MELAMINE POLYPHOSPHATE (MPP):
*Halogen-free and low poison, comply with European Environmental Protection requirements.
*Easy process, no need special screws combination and special grade glass fiber.
*Different from general halogen retardant, no corrosion damage to equipment and mold.
*Good heat stability, decomposition temperature>360°C, suitable for glass fiber-reinforced nylon.
*Melamine polyphosphate (MPP) contains different partical size grades.



FEATURES OF MELAMINE POLYPHOSPHATE (MPP):
*Halogen‐free and low poison, comply with European Environmental Protection requirements.
*Easy process, no need for special screw combination and special grade glass fiber.
*Different from general halogen retardant, no corrosion damage to equipment and mold.
*Good heat stability, decomposition temperature>360°C, suitable for glass fiber‐reinforced nylon.
*Melamine polyphosphate (MPP) contains different particle size grades.



PROPERTIES OF MELAMINE POLYPHOSPHATE (MPP):
*Environmental.
*Halogen-free, nitrogen-phosphorus intumescent flame retardant.
*Good thermal stability, easy to produce and process plastic products.
*Decomposition temperature >350°C, processing temperature can reach 300°C.
*Small fuming, low smoke production, low density of smoke produced.
*Small water solubility, no moisture absorption.



FEATURES OF MELAMINE POLYPHOSPHATE (MPP):
a) The flame retardant mechanism is nitrogen and phosphorus synergistic, and Melamine polyphosphate (MPP) is an environmentally friendly flame retardant.
b) The decomposition temperature is higher than that of melamine phosphate, and the processing process does not affect the surface finish of the substrate.
c) Excellent weather resistance, because it does not contain bromine, Melamine polyphosphate (MPP) is resistant to ultraviolet rays and does not yellow.
d) Appearance is white crystalline solid powder, coloring, good dispersibility and low hygroscopicity.
e) Add Melamine polyphosphate (MPP) arbitrarily to the fire retardant coating without significantly increasing the viscosity of the coating.



FLAME RETARDENTS MECHANISM OF MELAMINE POLYPHOSPHATE (MPP):
Melamine decomposition, needs to absorb heat from the polymer to reduce the surface temperature of the substrate.
Decomposition temperature of Melamine salts is high.

Melamine polyphosphate (MPP) (containing nitrogen) release inert gases, these non-flammable gases can dilute oxygen, reducing the concentration of combustible gases.

Nitrogen-phosphorus synergist.
Phosphorus promote char-forming, Nitogen release inert gases which will promote the foaming and expansion of the carbonised char layer, so it can prevent the convection of heat and outside oxygen.



FEATURES OF MELAMINE POLYPHOSPHATE (MPP):
1) Good quality
2) Competitive price
3) Certificated
4) Professional standard packing
5) Mass customization production
6) Strong production ability



BENEFITS OF MELAMINE POLYPHOSPHATE (MPP):
Melamine polyphosphate (MPP) is a halogen-free flame retardant with high purity.
Melamine polyphosphate (MPP) is white fine powder.
Melamine polyphosphate (MPP) is with very high thermal stability.

Melamine polyphosphate (MPP) can be UL94V-0 rating for nylon 6 by adding other flame retardants (i.e. pentaerythritol & ammonium polyphosphate).
Melamine polyphosphate (MPP) is a halogen free FR and offers significant advantages in terms of fire safety. It will release lower smoke density, lower smoke toxicity and less corrosive gases.



FEATURES OF MELAMINE POLYPHOSPHATE (MPP):
- Halogen-free and low poison, meet European Environmental Protection requirements.
- Good processability without special screws combination and special specification glass fibre.
- Good heat stability, decomposition temperature>350°C, suitable for glass fiber-reinforced nylon66.
- Good dispersivity to enhance the mechanical properties of the processed products.Stable product quality to reduce the moisture absorption of the product and make it easy to preserve.



BENEFITS OF MELAMINE POLYPHOSPHATE (MPP):
*Halogen-free and very high thermal stability
*UL94V-0 rating for nylon 66
*UL94V-1 rating for nylon 6
*UL94V-0 rating for nylon 6 by adding other flame retardants (i.e. pentaerythritol & ammonium polyphosphate)



FEATURES OF MELAMINE POLYPHOSPHATE (MPP):
1. Zero halogen and low toxicity, Melamine polyphosphate (MPP) is an environmentally friendly flame retardant that meets European green environmental requirements.

2. Good processability, no need for special screw combinations or special specifications of fiberglass.

3. Good thermal stability, decomposition temperature ≥ 350 ℃, especially suitable for flame retardancy of fiberglass reinforced Melamine polyphosphate (MPP).

4. The FR-NP100 product has good dispersibility, enhances the mechanical properties of the processed product, slows down the moisture absorption of the product, and is easy to store.



PHYSICAL and CHEMICAL PROPERTIES of MELAMINE POLYPHOSPHATE (MPP):
Appearance: White powder
Nitrogen content: 39%~43.5%
Phosphorus content: 12%~15%
Moisture: ≤0.5
Particle size (D50): ≤5μm
CAS Number: 218768-84-4
Molecular Weight: N/A
Density: N/A
Boiling Point: N/A
Molecular Formula: C3H6N6.(H3PO4)n
Melting Point: N/A

MSDS: N/A
Flash Point: N/A
Appearance: White powder
Chemical Formula: HO(C3H7N6PO3)nH
N content (%): 42 to 44
P content (%): 12 to 14
pH value (10g/L): 4 to 6
Particle size µm MPP-A: D50 ≤ 2.5, D98 ≤ 30
Particle size µm MPP-B: D50 ≤ 1.7, D98 ≤ 18
Bulk density kg/m³: 300 to 500
Solubility (20°C) g/L: ≤ 0.05

Decomposition temperature MPP-A: ≥ 375°C
Decomposition temperature MPP-B: ≥ 360°C
CBNumber: CB8212566
Molecular Formula: C3H9N6O4P
Molecular Weight: 224.12
MDL Number: MFCD00060248
MOL File: 20208-95-1.mol
Solubility: DMSO (Slightly), Methanol (Slightly)
Form: Solid
Color: White to Off-White
FDA UNII: DOS5Q2BU94
EPA Substance Registry System: 1,3,5-Triazine-2,4,6-triamine, phosphate (1:1) (20208-95-1)
CAS No.: 218768-84-4

Specs: Flame retardant
Molecular Formula: C3H6N6.(H3PO4)n
Appearance: White powder
CAS No.: 218768-84-4
Specifications:
P (%): 14 min
N (%): 35 min
Density (g/cm³): 1.74
Decomposition temperature: 300℃ min
Solubility in water (25℃ g/100 ml H2O): 0.1 g/100 ml H2O max
pH: 5.0~7.0
Average Particle size: 15μm max



FIRST AID MEASURES of MELAMINE POLYPHOSPHATE (MPP):
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of MELAMINE POLYPHOSPHATE (MPP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of MELAMINE POLYPHOSPHATE (MPP):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of MELAMINE POLYPHOSPHATE (MPP):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MELAMINE POLYPHOSPHATE (MPP):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of MELAMINE POLYPHOSPHATE (MPP):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available


Mélanine
MENTHOL, N° CAS : 1490-04-6 / 2216-51-5 / 89-78-1 / 15356-70-4 - Menthol. Autres langues : Mentol, Mentolo. Nom INCI : MENTHOL. Nom chimique : Cyclohexanol, 5-methyl-2-(1-methylethyl)-, N° EINECS/ELINCS : 216-074-4 / 218-690-9 / 201-939-0 / 239-388-3, Le menthol fait partie de la famille des alcools, il est obtenu à partir des huiles de menthe ou menthe poivrée. Il a une odeur de menthe poivrée. Il est connu pour ses effets tonifiants et rafraîchissants pour la peau. Ses fonctions (INCI). Dénaturant : Rend les cosmétiques désagréables. Principalement ajouté aux cosmétiques contenant de l'alcool éthylique. Le menthol est un composé organique covalent obtenu soit par synthèse, soit par extraction à partir de l'huile essentielle de menthe poivrée ou d'autres huiles essentielles de menthe. Le stéréoisomère le plus courant du menthol est le (–)-menthol, de configuration (1R,2S,5R). Il appartient à la famille des monoterpénols. À température ambiante (20 à 25 °C), il se trouve sous forme de cristaux, d'une couleur blanc cireux. Il fond si l'on augmente légèrement la température. Le menthol a des propriétés anti-inflammatoires et antivirales. Il est d'ailleurs utilisé pour soulager les irritations mineures de la gorge. C'est également un anesthésique local.Nom UICPA (1R,2S,5R)-5-méthyl-2-(propan-2-yl)cyclohexanol. Synonymes : 5-méthyl-2-(1-méthyléthyl)-cyclohexan-1-ol, (1R,2S,5R)-2-isopropyl-5-méthylcyclohexanol. No CAS 89-78-1, racémique, 2216-51-5, (−)-isomère, 15356-60-2(+)-isomère, Le menthol est inclus dans nombre de produits différents pour plusieurs raisons comme : soulagement à court terme de la gorge endolorie et de l'irritation mineure de la bouche ou de la gorge (bains de bouche par exemple) ; antipruritique, pour réduire les démangeaisons ; anesthésique local pour soulager des maux et douleurs mineures telles que des crampes musculaires, entorses, migraines. Il peut être utilisé seul ou combiné à du piment ou du camphre. En Europe, il est plutôt utilisé en gel ou en crème ; décongestionnant pour les voies respiratoires et les sinus ; pesticide contre les acariens (acaricide) ; dans certains médicaments traitant les brûlures mineures, il produit une sensation de froid (souvent utilisés en application locale, en association avec l'aloès) ; additif dans certaines cigarettes, comme saveur, pour réduire l'âcreté, favoriser l'inhalation profonde de la fumée et augmenter l'addiction9 ; additif dans certaines saveurs de liquides pour cigarettes électroniques ; comme désinfectant pour l'hygiène orale, ou remède contre la mauvaise haleine, comme collutoire, dans les pâtes dentifrices, et plus généralement comme agent de saveur pour les chewing-gums et les sucreries ; dans les sodas, aussi bien mélangé avec de l'eau pour obtenir une boisson à très faible teneur en alcool, comme dans le Ricqlès (on fait ici référence à la boisson, et non à l'alcool de menthe de la même marque) ;en versant quelques gouttes d'alcool de menthe sur un morceau de sucre pour soulager la nausée ; pour préparer des esters menthylés afin d'agrémenter des notes florales en parfumerie ; en patchs pour faire tomber la fièvre ou obtenir une sensation de froid (très développé au Japon) ; additif à certains produits de beauté (produits coiffants par exemple). Les défenseurs de l'homéopathie pensent que le menthol interfère avec les produits homéopathiques. Son utilisation est fortement déconseillée en association avec ceux-ci, au point de proscrire les dentifrices à base de menthol. Le menthol peut être utilisé en aromathérapie sous forme d'huile essentielle de menthe poivrée (médecine naturelle), l'indigestion, la nausée, les maux de gorge, la diarrhée, les maux de tête et les refroidissements (médecine orientale). Le menthol a une toxicité relativement basse : DL50 de 3 300 mg·kg-1 pour le rat, oral ; DL50 de 15 800 mg kg−1 pour le lapin, peau.En chimie organique, le menthol est utilisé comme auxiliaire chiral dans la synthèse de centres asymétriques. Agent masquant : Réduit ou inhibe l'odeur ou le goût de base du produit. Agent rafraîchissant : Procure une fraîcheur agréable à la peau. Agent apaisant : Aide à alléger l'inconfort de la peau ou du cuir chevelu. L-(-)-Menthol (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexanol (-)-(1R,2S,5R)-Menthol (-)-(1R,3R,4S)-Menthol (−)-menthol (-)-Menthol (-)-MENTHYL ALCOHOL (-)-p-Menthan-3-ol (-)-trans-p-Methan-cis-3-ol (1R)-(-)-Menthol (1R,2S,5R)-(-)-Menthol (1R,2S,5R)-(−)-Menthol (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol [ACD/IUPAC Name] (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol [German] [ACD/IUPAC Name] (1R,2S,5R)-2-Isopropyl-5-méthylcyclohexanol [French] [ACD/IUPAC Name] (1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol (R)-(-)-Menthol [1R-(1a,2b,5a)]-5-Methyl-2-(1-methylethyl)cyclohexanol 201-939-0 [EINECS] 218-690-9 [EINECS] 2216-51-5 [RN] 89-78-1 [RN] Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- [ACD/Index Name] levo-menthol Levomenthol [BAN] Levomentholum [Latin] L-Menthol [JP15] Menthol Menthol, l- (-)-trans-p-Menthan-cis-ol (±)-Menthol (±)-Menthol (l)-Menthol 1490-04-6 [RN] 15356-20-4 [RN] 239-388-3 [EINECS] 5-methyl-2-propan-2-ylcyclohexan-1-ol 63975-60-0 [RN] 6515-58-8 [RN] 98167-53-4 [RN] dl-mentho hexahydrothymol L(-)-Menthol Laevo-Menthol Leavo-menthol Levomentholum levomentol Menthacamphor MENTHOL (L) Menthol racemic Menthol, (1R,3R,4S)-(-)- Menthol, cis-1,3,trans-1,4- MFCD00001484 [MDL number] MFCD00062983 [MDL number] MFCD00064814 [MDL number] Peppermint camphor;Menthol WLN: L6TJ AY1&1 BQ D1 WLN: L6TJ AY1&1 DQ D1 -L 薄荷醇 [Chinese]
MELAPUR 200 (MELAMINE POLYPHOSPHATE)

Melapur 200, also known as melamine polyphosphate, is a chemical compound primarily used as a flame retardant and smoke suppressant in various applications, particularly in plastics, coatings, textiles, and construction materials.
Melapur 200 (Melamine Polyphosphate) is a type of intumescent flame retardant, meaning it undergoes a chemical reaction when exposed to heat or flames, forming a protective char layer that insulates the underlying material and inhibits the spread of fire.

CAS Number: 218768-84-4
EC Number: 244-575-5

Melapur 200, MPP, Melamine phosphate, Melaphos, Melapur MP, Melapur 110, Melamine acid phosphate, Melaminephosphoric acid, Melamine-pyrophosphoric acid, Melamid 25, Melamine orthophosphate, Melapur MP 200, Melaphos 201, Melapur MP-200, Melapur MP 100, Melaminophosphoric acid, Melaminepyrophosphoric acid, Melaminic acid phosphate, Melaminic acid phosphoric ester, Melapur 200F, Melapur MP100, Melapur 200F-40, Melapur 200-F 40, Melaminphosphorsäure, Melamin-pyrophosphorsäure, Melamin phosphorsäure, Melapur 100, Melapur 100F, Melapur MPF, Melamin phosphorsäureester, Melapur MP-100, Melapur MPF-40, Melapur MP 200F-40, Melapur MP 100F, Melaphos MP-100, Melapur MP 100 F, Melaminophosphorsäureester, Melamin-phosphorsäureester, Melapur MP 100-F, Melapur MP 100F-40, Melapur MP 100 F-40, Melapur MPF-20, Melaminphosphorsäureesterverbindung, Melamin-phosphorsäureesterverbindung, Melapur MPF-15, Melapur MP 100-F 40, Melapur 200F-20, Melapur MP 200-F20, Melapur MP 100 F-20, Melaphos 100F, Melaminphosphorsäureverbindung, Melamin-phosphorsäureverbindung, Melaminophosphorsäureverbindung, Melapur MPF-50, Melapur MPF-25, Melamin-phosphorsäureester


APPLICATIONS

Melapur 200 (Melamine Polyphosphate) is commonly used as a flame retardant additive in the production of polymer-based materials.
Melapur 200 (Melamine Polyphosphate) finds extensive application in the manufacturing of flame-retardant plastics, including polyethylene, polypropylene, and polyethylene terephthalate (PET).

Melapur 200 (Melamine Polyphosphate) is utilized in the formulation of fire-resistant coatings and paints for architectural, industrial, and automotive applications.
Melapur 200 (Melamine Polyphosphate) is incorporated into intumescent coatings, which swell and form a protective char layer when exposed to fire, providing passive fire protection.

Melapur 200 (Melamine Polyphosphate) is employed in the production of flame-retardant textiles, such as curtains, upholstery fabrics, and protective clothing.
Melapur 200 (Melamine Polyphosphate) is used in the manufacturing of flame-retardant foams for upholstered furniture, mattresses, and automotive seating.

Melapur 200 (Melamine Polyphosphate) is added to thermosetting resins, such as epoxy and phenolic resins, to impart fire resistance to composite materials and laminates.
Melapur 200 (Melamine Polyphosphate) is utilized in the production of flame-retardant adhesives and sealants for construction, electronics, and aerospace applications.
Melapur 200 (Melamine Polyphosphate) is incorporated into electrical and electronic components to improve their fire safety performance and comply with industry standards.

Melapur 200 (Melamine Polyphosphate) is used in the production of fire-resistant cable insulation and sheathing materials for applications requiring enhanced electrical safety.
Melapur 200 (Melamine Polyphosphate) finds application in the formulation of fire-resistant coatings for wood, plywood, and engineered wood products.

Melapur 200 (Melamine Polyphosphate) is added to paper and cardboard products to enhance their fire resistance and reduce the risk of fire propagation.
Melapur 200 (Melamine Polyphosphate) is employed in the production of fire-resistant thermoplastic elastomers (TPEs) for automotive, wire and cable, and consumer goods applications.

Melapur 200 (Melamine Polyphosphate) is utilized in the manufacturing of fire-resistant building materials, including insulation boards, roofing membranes, and wall panels.
Melapur 200 (Melamine Polyphosphate) is added to polyurethane foams to improve their fire safety properties and meet regulatory requirements for construction materials.

Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant gaskets, seals, and packing materials for industrial and automotive applications.
Melapur 200 (Melamine Polyphosphate) is used in the formulation of fire-retardant coatings for steel and other structural materials to enhance their fire resistance.

Melapur 200 (Melamine Polyphosphate) is added to polymer composites used in marine applications to reduce the flammability of boat components and structures.
Melapur 200 (Melamine Polyphosphate) is employed in the production of fire-resistant paints and coatings for offshore platforms, oil refineries, and chemical processing plants.

Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant molded products, such as electrical enclosures, junction boxes, and circuit breakers.
Melapur 200 (Melamine Polyphosphate) is added to plastic films and packaging materials to improve their fire resistance and reduce the risk of fire spread.

Melapur 200 (Melamine Polyphosphate) is utilized in the formulation of fire-resistant insulating materials for thermal and acoustic insulation in buildings and industrial equipment.
Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant automotive components, such as dashboard panels, door trims, and engine covers.

Melapur 200 (Melamine Polyphosphate) is added to rubber compounds used in conveyor belts, hoses, and automotive tires to enhance their fire resistance.
Melapur 200 (Melamine Polyphosphate) is employed in the formulation of fire-resistant coatings for metal surfaces, such as steel beams, columns, and structural supports, to improve their fire safety performance.

Melapur 200 (Melamine Polyphosphate) is used in the production of fire-resistant paints and coatings for industrial equipment, machinery, and storage tanks.
Melapur 200 (Melamine Polyphosphate) finds application in the formulation of fire-resistant insulation materials for HVAC (heating, ventilation, and air conditioning) systems and ductwork.

Melapur 200 (Melamine Polyphosphate) is incorporated into fireproof barriers and partitions to compartmentalize spaces and prevent the spread of fire.
Melapur 200 (Melamine Polyphosphate) is added to plastic pipes and fittings used in plumbing and construction to improve their fire performance.

Melapur 200 (Melamine Polyphosphate) is utilized in the production of fire-resistant flooring materials, including vinyl tiles, laminate flooring, and carpet backing.
Melapur 200 (Melamine Polyphosphate) finds application in the formulation of fire-retardant paints and coatings for interior walls, ceilings, and structural elements.

Melapur 200 (Melamine Polyphosphate) is added to foam insulation boards and panels to enhance their fire resistance and thermal insulation properties.
Melapur 200 (Melamine Polyphosphate) is employed in the production of fire-resistant door cores and frames for commercial and residential buildings.
Melapur 200 (Melamine Polyphosphate) is used in the formulation of fire-resistant sealants and caulks for joints, gaps, and penetrations in building construction.

Melapur 200 (Melamine Polyphosphate) is incorporated into fire blankets and curtains used for emergency fire suppression and containment.
Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant textiles for industrial applications, such as welding blankets and protective clothing.

Melapur 200 (Melamine Polyphosphate) is added to fireproof coatings for structural steel and concrete to improve their fire resistance and structural integrity.
Melapur 200 (Melamine Polyphosphate) is utilized in the formulation of fire-resistant coatings for electrical enclosures, switchgear, and control panels.

Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant decorative laminates and veneers for interior finishes and furniture.
Melapur 200 (Melamine Polyphosphate) is added to fire-resistant glazing systems for windows, doors, and curtain walls in commercial buildings.
Melapur 200 (Melamine Polyphosphate) is incorporated into fire-resistant mortar and grout used in construction to improve their fire performance.

Melapur 200 (Melamine Polyphosphate) is utilized in the formulation of fire-resistant tapes and adhesives for bonding and sealing applications in high-temperature environments.
Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant concrete additives and admixtures for structural and non-structural applications.

Melapur 200 (Melamine Polyphosphate) is added to fire-resistant coatings for steel structures in industrial facilities, such as refineries and power plants.
Melapur 200 (Melamine Polyphosphate) is employed in the formulation of fire-resistant coatings for air ducts, chimneys, and exhaust systems in commercial and industrial buildings.

Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant composites for aerospace, marine, and transportation applications.
Melapur 200 (Melamine Polyphosphate) is added to fire-resistant mastics and putties for firestopping and penetration sealing in building construction.

Melapur 200 (Melamine Polyphosphate) is utilized in the formulation of fire-resistant lubricants and greases for high-temperature applications in industrial machinery.
Melapur 200 (Melamine Polyphosphate) finds application in the production of fire-resistant membranes and barriers for waterproofing and vapor control in building envelopes.
Melapur 200 (Melamine Polyphosphate) is incorporated into fire-resistant coatings for exterior cladding systems to enhance their fire performance and weather resistance.



DESCRIPTION


Melapur 200, also known as melamine polyphosphate, is a chemical compound primarily used as a flame retardant and smoke suppressant in various applications, particularly in plastics, coatings, textiles, and construction materials.
Melapur 200 (Melamine Polyphosphate) is a type of intumescent flame retardant, meaning it undergoes a chemical reaction when exposed to heat or flames, forming a protective char layer that insulates the underlying material and inhibits the spread of fire.
Melapur 200 (Melamine Polyphosphate) is valued for its effectiveness in improving the fire safety properties of a wide range of materials while offering advantages such as thermal stability, low toxicity, and compatibility with various polymers.
Melapur 200 (Melamine Polyphosphate) is commonly used in industries where fire safety is a critical concern, such as automotive, electronics, and building construction.

Melamine polyphosphate is a white, crystalline powder with a fine texture.
Melapur 200 (Melamine Polyphosphate) exhibits excellent flame-retardant properties, making it highly effective in reducing the spread of fire.

Melapur 200 (Melamine Polyphosphate) forms a protective char layer when exposed to heat or flames, which acts as a barrier against further combustion.
Melapur 200 (Melamine Polyphosphate) is odorless and non-toxic, making it suitable for use in various applications where safety is paramount.
Melapur 200 (Melamine Polyphosphate) is soluble in water and compatible with a wide range of polymers, including plastics, resins, and rubbers.

This flame retardant is characterized by its high thermal stability, retaining its effectiveness even at elevated temperatures.
Melamine polyphosphate is often used in combination with other flame retardants to achieve synergistic effects and improve overall fire resistance.

Melapur 200 (Melamine Polyphosphate) is commonly employed in the manufacturing of fire-resistant coatings, paints, and sealants for building materials and structural components.
Melapur 200 (Melamine Polyphosphate) is also utilized in the production of flame-retardant textiles, carpets, and upholstery fabrics.
Melamine polyphosphate can be incorporated into polymer matrices through various processing methods, including blending, compounding, and extrusion.

Melapur 200 (Melamine Polyphosphate) imparts minimal changes to the physical properties of materials, such as mechanical strength, flexibility, and color.
The compound's low toxicity profile and environmental compatibility make it a preferred choice for flame retardant formulations.

Melapur 200 (Melamine Polyphosphate) exhibits excellent compatibility with halogen-containing flame retardants, enhancing their performance in fire-resistant applications.
It is known for its ability to suppress smoke and toxic gas emissions during combustion, contributing to improved fire safety in enclosed spaces.
Melapur 200 (Melamine Polyphosphate) is resistant to leaching and migration, ensuring long-lasting fire protection in treated materials.

Melapur 200 (Melamine Polyphosphate) demonstrates good dispersibility in polymer matrices, facilitating uniform distribution and effective flame retardant action.
Melapur 200 (Melamine Polyphosphate) is stable under a wide range of processing conditions, including high shear rates, temperatures, and pressures.

Melapur 200 (Melamine Polyphosphate) offers cost-effective fire protection solutions compared to some alternative flame retardants.
Its versatility and compatibility with various substrates make it suitable for use in diverse industries, including construction, automotive, and electronics.

Melapur 200 (Melamine Polyphosphate) undergoes controlled decomposition when exposed to fire, releasing inert gases that dilute oxygen and inhibit combustion.
Melapur 200 (Melamine Polyphosphate) is characterized by its high purity and consistency, ensuring reliable performance in flame retardant applications.

Melapur 200 (Melamine Polyphosphate) is resistant to hydrolysis and degradation, maintaining its fire-retardant properties over extended periods of time.
Melapur 200 (Melamine Polyphosphate)'s low dusting properties minimize handling hazards and reduce the risk of airborne contamination during processing.

Melapur 200 (Melamine Polyphosphate) complies with stringent regulatory requirements and industry standards for fire safety and environmental protection.
Its effectiveness, versatility, and safety profile make melamine polyphosphate a valuable additive in materials requiring enhanced flame resistance.



PROPERTIES


Appearance: White powder
Chemical Formula: HO(C3H7N6PO3)nH
N content (%): 42 to 44
P content (%): 12 to 14
pH value (10g/L): 4 to 6
Particle size µm MPP-A: D50 ≤ 2.5, D98 ≤ 30
Particle size µm MPP-B: D50 ≤ 1.7, D98 ≤ 18
Bulk density kg/m³: 300 to 500
Solubility (20°C) g/L: ≤ 0.05
Decomposition temperature MPP-A: ≥ 375°C
Decomposition temperature MPP-B: ≥ 360°C



FIRST AID



Inhalation:

Move to Fresh Air:
If exposed to melamine polyphosphate dust or fumes, immediately move the affected person to an area with fresh air.

Ensure Breathing:
Ensure that the affected person is breathing and monitor their respiratory status.

Seek Medical Attention:
If symptoms such as difficulty breathing, coughing, or respiratory distress persist, seek medical attention promptly.

Provide Oxygen:
If available and trained to do so, administer oxygen to the affected person while awaiting medical assistance.

Keep Warm and Rested:
Keep the affected person warm and in a resting position to aid in recovery and minimize discomfort.


Skin Contact:

Remove Contaminated Clothing:
If melamine polyphosphate comes into contact with the skin, promptly remove any contaminated clothing.

Wash Skin Thoroughly:
Wash the affected area with soap and water for at least 15 minutes, ensuring thorough rinsing to remove any traces of melamine polyphosphate.

Use Mild Soap:
Use a mild soap or detergent to gently cleanse the skin, avoiding harsh chemicals that may exacerbate irritation.

Apply Moisturizer:
After washing, apply a soothing moisturizer or emollient to the affected area to help soothe and hydrate the skin.

Seek Medical Advice:
If skin irritation persists or worsens, seek medical advice or consult a healthcare professional for further evaluation and treatment.


Eye Contact:

Flush with Water:
Immediately flush the eyes with lukewarm water for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.

Remove Contact Lenses:
If wearing contact lenses, remove them as soon as possible to facilitate irrigation of the eyes.

Seek Medical Attention:
Seek immediate medical attention or contact an eye specialist if irritation, pain, or redness persists after flushing.


Ingestion:

Do Not Induce Vomiting:
Do not induce vomiting if melamine polyphosphate has been ingested, as it may lead to further complications.

Do Not Drink Water:
Refrain from giving anything by mouth to the affected person unless instructed by medical personnel.

Seek Medical Assistance:
Immediately contact a poison control center or seek medical assistance for further guidance and treatment.

Provide Information:
Provide medical personnel with details regarding the amount ingested, the time of ingestion, and any symptoms experienced by the affected person.



HANDLING AND STORAGE


Handling:


Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety glasses or goggles, and protective clothing (such as long sleeves and pants), when handling melamine polyphosphate to minimize skin and eye contact.

Avoid Inhalation:
Avoid breathing in dust or fumes generated during handling.
Use local exhaust ventilation or wear a respiratory protective device if necessary.

Prevent Skin Contact:
Prevent skin contact by wearing gloves and long-sleeved clothing.
In case of skin contact, wash affected areas thoroughly with soap and water.

Prevent Eye Contact:
Wear safety glasses or goggles to protect eyes from potential splashes.
In case of eye contact, flush eyes with water immediately and seek medical attention if irritation persists.

Minimize Dust Generation:
Handle melamine polyphosphate in a manner that minimizes dust generation.
Use appropriate handling and transfer equipment to reduce the risk of airborne exposure.

Avoid Contamination:
Prevent contamination of food, beverages, and tobacco products with melamine polyphosphate.
Wash hands thoroughly after handling and before eating, drinking, or smoking.

Dispose of Waste Properly:
Dispose of waste materials, such as empty containers or spilled product, in accordance with local regulations and guidelines for hazardous waste disposal.


Storage:

Container Selection:
Store melamine polyphosphate in tightly sealed containers made of compatible materials, such as polyethylene or stainless steel, to prevent moisture ingress and contamination.

Labeling:
Clearly label containers with the product name, hazard symbols, handling instructions, and storage conditions to ensure proper identification and safe handling.

Temperature Control:
Store melamine polyphosphate in a cool, dry place away from direct sunlight and heat sources.
Avoid exposure to extreme temperatures, which may affect product stability.

Ventilation:
Ensure adequate ventilation in storage areas to prevent the buildup of dust or vapors.
Use mechanical ventilation or natural ventilation as appropriate.

Separation:
Store melamine polyphosphate away from incompatible materials, including acids, bases, oxidizing agents, and strong reducing agents, to prevent chemical reactions or hazards.

Avoid Stacking:
Avoid stacking containers of melamine polyphosphate to prevent damage or collapse.
Store containers on shelves or racks with adequate support and spacing.

Handling Precautions:
Handle containers with care to prevent spills or leaks.
Use appropriate lifting equipment and techniques when moving or transporting heavy containers.

Security Measures:
Implement security measures, such as locked storage areas or restricted access, to prevent unauthorized handling or tampering with melamine polyphosphate.

Emergency Response:
Have appropriate spill containment and cleanup materials readily available in case of spills or leaks.
Train personnel on proper spill response procedures and emergency protocols.
MELAPUR 200/70
Melapur 200/70 is a halogen-free, flame retardant based on melamine polyphosphate.
Upon exposure to strong fire, Melapur 200/70 forms a stable char which protects the polymer and prevents further flame propagation.
Melapur 200/70 is compliant with UL 94 V0 (0.8 mm) at 25% by weight.

CAS: 218768-84-4
MF: C3H6N6.(H3PO4)n
EINECS: 239-590-1

MELAPUR 200/70 is a salt of melamine and polyphosphoric acid,
suitable as flame retardant for glass fiber reinforced polyamide 66.
MELAPUR 200/70 is a melamine based halogen free flame retardant for glass fiber reinforced
polyamide 66.
MELAPUR 200/70, melamine polyphosphate, is a halogen-free flame retardant specially developed
for glass fiber reinforced polyamide 66.
As a white powder Melapur 200/70 opens up new and broader color
schemes for flame retarded glass fiber reinforced PA 66.
The mechanism is based on intumescence.
At exposure to fire a strong and stable char is formed which protects the polymer and prevents.
The good balance between intumescence and thermal stability of MELAPUR 200/70 provides a
processing window of up to 320 o C.
Excellent health and safety data offer additional handling and processing advantages.

Synonyms
Melapur 200
Melapur M 200
Melamine Polyphosphate(FR-NP)
FR-NP
Fr-Np Melamine Polyphosphate
Melamine phosphate
20208-95-1
1,3,5-Triazine-2,4,6-triamine, phosphate
41583-09-9
1,3,5-triazine-2,4,6-triamine phosphate
Triazinetriaminephosphate
melamine monophosphate
EINECS 255-449-7
218768-84-4
phosphoric acid;1,3,5-triazine-2,4,6-triamine
DOS5Q2BU94
1,3,5-Triazine-2,4,6-triamine, phosphate (1:1)
1,3,5-Triazine-2,4,6-triamine monophosphate
EINECS 243-601-5
1,3,5-Triazine-2,4,6-triamine, phosphate (1:?)
EC 255-449-7
hate
INTUMESCENTCOMPOUNDKE8000
Melamine Polyphosp
EINECS 260-493-5
UNII-DOS5Q2BU94
C3H6N6.xH3O4P
SCHEMBL73239
C3H6N6.H3O4P
DTXSID80872787
XFZRQAZGUOTJCS-UHFFFAOYSA-N
C3-H6-N6.H3-O4-P
C3-H6-N6.x-H3-O4-P
MELAMINE, PHOSPHATE (1:1)
MFCD00060248
AKOS028108538
AS-15268
CS-0449429
FT-0628188
FT-0742330
F71215
Di(1,3,5-triazine-2,4,6-triamine) phosphate
1,3,5-Triazine-2,4,6-triamine, phosphate (2:1)
Melia azadirachta
melia azadirachta extract; extract of the neem tree, melia azadirachta l., meliaceae; chinaberry leaf; margosa leaf CAS NO: 90063-92-6
Melilotus officinalis
brachylobus officinalis absolute; sweet clover absolute; melilotus officinalis absolute; sertula officinalis absolute; sweet clover absolute; trifolium officinale absolute CAS NO:8023-73-2
Melissa officinalis
lemon balm; bee balm; sweet balm; balm lemon; melissa bicornis; xiang feng hua CAS NO:977051-08-3
MELMENT F 10
Melment F 10 Description Melamine Superplasticizer Melment F 10 Technical Data Sheet Chemical Nature Melment F 10 is free-flowing spray dried powder of a sulphonated polycondensation product based on melamine. Superplasticizer for cement and calcium sulphate based materials. Properties Typical Properties Physical shape powder Appearance characteristic, white to slightly colored Drying loss max. 4.0% Bulk density 500 – 800 kg/m³ Dosage recommendation 0.20 – 2.00% by weight of cementitious materials pH value at 20 ˚C, 20% solution 9.0 – 11.4 Applications Fields of application Melment® F 10 is especially optimized for plastification and water reduction of cement and calcium sulphate based materials; including the following: • Self-leveling underlayments (SLU) • Feather edge products • Cementitious floor screeds • Dry-mix concrete • Repair mortars • Non-shrink grouts • Cementitious self leveling floor screeds • Tile adhesives and joint fillers Safety General The usual safety precautions when handling chemicals must be observed. These include the measures described in Federal, State and Local health and safety regulations, thorough ventilation of the workplace, good skin care and wearing of protective goggles. Material Safety Data Sheet All safety information is provided in the Material Safety Data Sheet for Melment F 10. Transport Regulation Not known as a dangerous good according to transport regulations. Product Description Leveraging on our vast industrial experience, we offer an extensive range of Melamine Powder. This product is processed in conformity with international standards using certified chemical compounds with the help of highly advanced techniques. This product is meticulously tested by our vendors on well defined parameters to ensure its optimum quality, precise pH value and purity. Apart from this, we offer this product at industry leading rates within promised time-frame. Features: Precise pH value Optimum quality Purity Fields of Application: MELMENT F 10 is especially optimized for plastification and water reduction of cement based materials. Self-levelling underlayments (SLU) Feather-edge products Non-shrink grouts Cementitious floor screeds Cementitious self-levelling floor screeds Tiles adhesives and joint fillers Repair mortars Dry-mix concrete Packaging: 25 kg paper bag 100 kg big bag Melamine Superplasticizer melment f10 similared superplasticizer SMF Melamine Sulphonate Superplasticizer is a high range water reducing admixture. We are one of the best superplasticizer manufacturers in China. SMF Melamine Sulphonate Superplasticizer is a free flowing, spray dried powder of polycarboxylate resin. It's environment-friendly and widely applied to high performance concrete. It's dispersiveness is good, water reducing rate is high and adaptability to various cement. Fluidity of ixtures is excellent when used in concrete and mortar. It's also an excellent dispersion plasticizer suitable for gypsum, ceramic and other mineral materials Specification for Melamine Sulphonate Superplasticizer Appearance Light yellow powder Solid content(%) 95Min Density(Kg/m3) 500-600 Moisture (%) 5.0Max Alkali content (%) 5.0Max Cl content (%) 0.2Max PH Value (1%Sol.) 8.0-9.5 3. Advantage for Melamine Sulphonate Superplasticizer Advantage:of Polycarboxylate based superplasticizer Lower dosage: high water reducing (25-40%), and cement save 15-30%. Low slump loss: less than 20% during two hours. Good compatibility: mix with many kinds of cements and admixtures. Lower shrinkage: improve compression of fresh mixed concrete. Low chloride and alkali content, no corrosion to rebar. High stability: no precipitation at low temperature Application 4. Application for Melamine Sulphonate Superplasticizer a. Long-distance transportation pump concrete b. Compounding high durable concrete required impermeability, high ability of keeping collapse and frost-resistance c. Compounding high flowing concrete, self-leveling grounds, fair-faced concrete and grouts materials, gypsum products d. Compounding concrete with high dosage of flyash and mineral powder MELMENT F10 is a melamine sulphonate based, powder form superplasticizer used in bagged manufacturing of powder products such as cement and gypsum. Usage places ■ In construction chemicals industry, cement-based powder manufacturing, ■ In the construction chemicals industry, gypsum-based powder manufacturing, ■ Where liquid superplasticizer is difficult to transport, ■ It is used in the production of mold plaster in the industry. Advantages ■ It increases the strength of powder products by reducing the mixing water. ■ Although it reduces the mixing water of powder products, it increases the processability. ■ It does not change the colors of powder-form products. Liquid superplasticizer is obtained easily by mixing with water on site ■ In order to increase the workability and strength of the mixture, at the rate of 0.5 - 0.9 kg, �� For leveling screeds and precast gypsum elements at a rate of 0.6 -1.5 kg, ■ It is used at the rate of 0.5-1.5 kg for plaster molds. The dosage of use is determined based on laboratory experiments. BASF - YKS Technical Service should be consulted for detailed information. Packaging 25 kg polletllen reinforced kraft bag Shelf Life It is 24 months from the production date under appropriate storage conditions, in its original packaging. Opened packages must be used within one week under appropriate storage conditions. Dosage MELMENT F10 in 100 kg binder: ■ In the ratio of 0.2 - 0.4 kg to increase the processability of the mixture, ■ In order to increase the strength of the mixture, at the rate of 0.3 - 0.6 kg Product description MELMENT F10 is a powder form superplasticizer based on melamine sulphonate which is used in bagged manufacturing of powder products such as cement and plaster. MELMENT® F 10 MELMENT F10 is a melamine sulphonate based, powder form superplasticizer used in bagged manufacturing of powder products such as cement and gypsum. Usage places In the construction chemicals industry, in cement-based powder manufacturing, Construction chemicals industry, gypsum-based powder manufacturing, Where liquid superplasticizer is difficult to transport, It is used in the production of mold plaster in the industry. Advantages It increases the strength of powder products by reducing the mixing water. Although it reduces the mixing water of powder products, it increases the processability. It does not change the color of powder products. A liquid superplasticizer is obtained easily mixed with water on site. 0.5 - 0.9 kg in order to increase the workability and strength of the mixture, 0.6 -1.5 kg for leveling screeds and precast gypsum elements, It is used at the rate of 0.5-1.5 kg for plaster molds. The dosage of use is determined based on laboratory experiments. Packaging 25 kg polletllen reinforced kraft bag Shelf life It is 24 months from the production date under appropriate storage conditions, in its original packaging. Opened packages must be used within one week under appropriate storage conditions. MELMENT F 10 MELMENT F 10 is a melamine sulphonate based, powder form superplasticizer that is used in the bagged manufacturing of powder products such as cement and plaster. Placeholder BASF-YKS MELMENT F 10 MELMENT F 10 is a melamine sulphonate based, powder form superplasticizer that is used in the bagged manufacturing of powder products such as cement and plaster. Categories: Concrete Additives. Tags: BASF-YKS, concrete. Explanation Product description Usage places In the construction chemicals industry, cement-based powder manufacturing, Construction chemicals industry, gypsum-based powder manufacturing, Where liquid superplasticizer is difficult to transport, It is used in the production of mold plaster in the industry. Advantages It increases the strength of powder products by reducing the mixing water. Although it reduces the mixing water of powder products, it increases the workability. It does not change the colors of powder-form products. A liquid superplasticizer is obtained easily mixed with water on site. Technicial Specifications Structure of the Material Melamine Sulphonate based Color White Density 1.8 - 1.9 kg / liter MELMENT® F 10 Definition MELMENT® F 10, melamine sulphonate based, cement and in the bagged manufacture of powder products such as plaster It is a powder form superplasticizer used. Usage places Cement based in the construction chemicals industry in powder manufacturing, Gypsum-based powder in the construction chemicals industry in manufacturing, Liquid superplasticizer is difficult to transport places, It is used in the production of mold plaster in the industry. Advantages Powder products' strength by reducing the mixing water increases. Although powder products reduce the mixing water It increases its workability. It does not change the colors of powder productions. Liquid can be easily mixed with water at the site. superplasticizer is obtained. Dosage MELMENT® F 10 in 100 kg binder: 0.2 - 0.4 to increase the workability of the mixture at the rate of kg, 0.3 - 0.6 kg to increase the strength of my mixture at the rate of Increasing the workability and strength of my mixture 0.5 - 0.9 kg for For leveling flaps and precast plaster elements At the rate of 0.6 - 1.5 kg, It is used at the rate of 0.5 - 1.5 kg for plaster molds. Usage depending on laboratory experiments waist dosage
MELMENT F 10

Melment F 10 is a chemical compound used as a pharmaceutical excipient in the formulation of tablets and capsules.
Melment F 10 is primarily composed of croscarmellose sodium, which is a cross-linked derivative of sodium carboxymethyl cellulose.
Melment F 10 is commonly used as a disintegrant in pharmaceutical formulations to promote the rapid disintegration of tablets upon ingestion.

CAS Number: 74811-65-7
EC Number: 629-739-2

Synonyms: Croscarmellose sodium, Sodium croscarmellose, Ac-Di-Sol, Primellose, K-Carrageenan, Ac-di-sol, HPC, Methocel, Sodium CMC, E466, Sodium carboxymethylcellulose, Carmellose sodium, Croscarmellose, Primellose sodium, Explotab, Ac-di-sol cross-linked, Cellulose gum sodium, Cross-linked sodium carboxymethylcellulose, Cross-linked carboxymethyl cellulose sodium, Modified cellulose sodium, Croscarmellose sodium, Sodium carboxymethyl cellulose crosslinked, Sodium starch glycolate, Microcrystalline cellulose, Avicel, Ethylcellulose, HPMC, Methylcellulose, Ethyl cellulose, Sodium starch glycolate, CMC, Pectin, Hydroxypropyl methylcellulose, E466, Sodium CMC, MC, Tylose, Carboxymethylcellulose sodium, Sodium salt of carboxymethyl cellulose, Cellulose gum, Carboxymethyl cellulose, Methyl cellulose, Tylose, Carboxymethyl cellulose sodium salt, Cellulose gum sodium, Polycarboxymethylene, Cellulose carboxymethyl ether, Sodium carboxymethyl cellulose, Modified cellulose, Cellulose gum, Modified cellulose sodium, Sodium cellulose carboxymethyl ether, Carboxymethyl cellulose sodium salt, Cellulose sodium salt, Modified starch, Cross-linked starch, Polycarboxylate starch



APPLICATIONS


Melment F 10 is primarily used as a disintegrant in pharmaceutical formulations.
Melment F 10 is extensively employed in the production of oral solid dosage forms, including tablets and capsules.
Melment F 10 promotes rapid disintegration of tablets upon ingestion, facilitating drug release and absorption in the gastrointestinal tract.
Melment F 10 is suitable for use in immediate-release, sustained-release, and controlled-release formulations.

Melment F 10 is commonly used in the formulation of generic and branded pharmaceutical products across a wide range of therapeutic categories.
Melment F 10 is compatible with various active pharmaceutical ingredients (APIs) and excipients.
Melment F 10 is employed in the formulation of tablets containing poorly soluble drugs to enhance their bioavailability.

Melment F 10 is used in combination with other excipients such as binders, lubricants, and fillers to optimize tablet performance.
The disintegrating efficiency of croscarmellose sodium is influenced by factors such as particle size, degree of cross-linking, and tablet compression force.

Melment F 10 is suitable for use in both direct compression and wet granulation tablet manufacturing processes.
Melment F 10 is often included in orally disintegrating tablet (ODT) formulations to improve patient compliance, particularly in pediatric and geriatric populations.
Melment F 10 is used in the production of fast-dissolving tablets and orally disintegrating films for rapid onset of action.

Melment F 10 is employed in the development of chewable tablets and effervescent dosage forms for ease of administration.
Melment F 10 is included in tablet formulations intended for patients with dysphagia or difficulty swallowing.
Melment F 10 is utilized in the formulation of herbal supplements, vitamins, and minerals in tablet form.

Melment F 10 is employed in veterinary medicine for the production of tablets and capsules for companion animals and livestock.
Melment F 10 is used in the development of over-the-counter (OTC) and prescription medications for various indications.
Melment F 10 is employed in the formulation of antipyretics, analgesics, anti-inflammatories, and cardiovascular drugs.

Melment F 10 is used in the production of allergy medications, cough and cold remedies, and respiratory therapies.
Melment F 10 is employed in the development of psychiatric medications, antidepressants, and anxiolytics.

Melment F 10 is included in formulations of anti-infective agents, antibiotics, and antiviral medications.
Melment F 10 is utilized in the development of hormone therapies, contraceptives, and reproductive health products.

Melment F 10 is employed in the production of dermatological medications, topical creams, and ointments for skin disorders.
Melment F 10 is used in the formulation of combination therapies for the treatment of complex diseases and conditions.
Melment F 10 is a versatile excipient with widespread applications in the pharmaceutical industry, contributing to the development of safe, effective, and patient-friendly dosage forms.

Melment F 10 is utilized in the formulation of pediatric medications such as antipyretics, analgesics, and antibiotics.
Melment F 10 is employed in the production of geriatric medications for elderly patients with specific dosage requirements.

Melment F 10 is used in the development of nutraceuticals and dietary supplements in tablet form.
Melment F 10 is included in formulations of probiotics, prebiotics, and digestive enzymes.

Melment F 10 is employed in the production of weight management supplements and appetite suppressants.
Melment F 10 is utilized in the formulation of sports nutrition products, energy boosters, and performance enhancers.

Melment F 10 is included in formulations of vitamins, minerals, and herbal extracts for health and wellness purposes.
Melment F 10 is employed in the development of personalized medicine and custom-compounded prescriptions.
Melment F 10 is used in the formulation of specialty medications for rare diseases and orphan conditions.

Melment F 10 is included in formulations of biosimilars and generic versions of biologic drugs.
Melment F 10 is employed in the production of targeted therapies, immunotherapies, and gene therapies.
Melment F 10 is utilized in the development of advanced drug delivery systems such as nanotechnology-based formulations.
Melment F 10 is included in formulations of supportive care medications for patients undergoing chemotherapy and radiation therapy.

Melment F 10 is employed in the formulation of combination therapies for the treatment of complex diseases such as cancer and autoimmune disorders.
Melment F 10 is utilized in the development of oral vaccines and immunization products.

Melment F 10 is included in formulations of antidiabetic medications and insulin analogs.
Melment F 10 is employed in the production of medications for chronic conditions such as hypertension and hyperlipidemia.
Melment F 10 is used in the formulation of anti-inflammatory drugs and disease-modifying agents.

Melment F 10 is included in formulations of anticoagulants, antiplatelet agents, and thrombolytics.
Melment F 10 is utilized in the development of medications for neurological disorders such as epilepsy and Parkinson's disease.
Melment F 10 is employed in the production of medications for gastrointestinal disorders such as irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD).

Melment F 10 is included in formulations of antineoplastic agents and supportive care medications for cancer patients.
Melment F 10 is utilized in the development of medications for infectious diseases such as HIV/AIDS, tuberculosis, and malaria.

Melment F 10 is employed in the production of medications for respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD).
Melment F 10 continues to be a critical component in the formulation of innovative pharmaceutical products aimed at addressing a wide range of medical conditions and therapeutic needs.

Melment F 10 is commonly used in tablet formulations to improve dissolution rates and bioavailability.
Melment F 10 undergoes rapid hydration and swelling upon exposure to aqueous fluids, leading to mechanical disruption of the tablet matrix.
The disintegrating efficiency of croscarmellose sodium is influenced by factors such as particle size and degree of cross-linking.

Melment F 10 is suitable for use in immediate-release, sustained-release, and controlled-release formulations.
Melment F 10 is commonly employed in the production of generic and branded pharmaceutical products.

Melment F 10 is employed in the development of orally disintegrating tablets (ODTs) for improved patient compliance.
Melment F 10 is used in the formulation of fast-dissolving tablets for rapid onset of action.
Melment F 10 is utilized in the production of chewable tablets for ease of administration.

Melment F 10 is included in formulations of vitamins, minerals, and herbal supplements in tablet form.
Melment F 10 is used in veterinary medicine for the production of tablets and capsules for companion animals and livestock.

Melment F 10 contributes to the uniformity and consistency of tablet disintegration across different manufacturing batches.
The versatility and effectiveness of croscarmellose sodium make it a preferred choice for formulators seeking rapid tablet disintegration.

Melment F 10 undergoes reversible hydration and swelling, allowing for efficient tablet disintegration without compromising tablet hardness.
Melment F 10 plays a crucial role in ensuring the effectiveness, safety, and patient compliance of solid oral dosage forms.
Melment F 10 is a vital pharmaceutical excipient that enhances the performance and functionality of tablets in various drug formulations.



DESCRIPTION


Melment F 10 is a chemical compound used as a pharmaceutical excipient in the formulation of tablets and capsules.
Melment F 10 is primarily composed of croscarmellose sodium, which is a cross-linked derivative of sodium carboxymethyl cellulose.
Melment F 10 is commonly used as a disintegrant in pharmaceutical formulations to promote the rapid disintegration of tablets upon ingestion.
This facilitates the release of the active pharmaceutical ingredient (API) for absorption in the gastrointestinal tract.

Melment F 10 is highly effective in promoting tablet disintegration and has excellent swelling properties when exposed to water.
Melment F 10 is insoluble in organic solvents but disperses readily in water to form colloidal solutions.
Melment F 10 is chemically stable under normal storage conditions and is derived from natural cellulose sources.

In pharmaceutical formulations, Melment F 10 plays a crucial role in ensuring the efficacy and bioavailability of orally administered drugs by facilitating their rapid disintegration and dissolution in the body.
Melment F 10 is included in the list of inactive ingredients approved by regulatory authorities such as the United States Food and Drug Administration (FDA) and is widely used in the pharmaceutical industry for its disintegrating properties.

Melment F 10 is a white to slightly off-white, tasteless, and odorless powder.
Melment F 10 is a cross-linked derivative of sodium carboxymethyl cellulose, derived from natural cellulose sources.

Melment F 10 exhibits excellent swelling properties when exposed to water, leading to rapid disintegration of tablets.
Croscarmellose sodium is highly hygroscopic, absorbing moisture from the environment.
Melment F 10 is insoluble in organic solvents but disperses readily in water to form colloidal solutions.

Melment F 10 is chemically stable under normal storage conditions.
Melment F 10 is widely used as a disintegrant in pharmaceutical formulations.

Melment F 10 is included in the list of inactive ingredients approved by regulatory authorities such as the FDA.
The disintegrating action of croscarmellose sodium facilitates drug release and absorption in the gastrointestinal tract.
Melment F 10 is compatible with a wide range of active pharmaceutical ingredients (APIs) and excipients.



PROPERTIES


Physical Properties:

Appearance: White to slightly off-white, tasteless, odorless powder
Particle Size: Variable, typically in the range of 50-200 micrometers (μm)
Bulk Density: Approximately 0.3-0.6 g/cm³
Melting Point: Decomposes before melting
Solubility: Insoluble in organic solvents; dispersible in water to form colloidal solutions
Hygroscopicity: Highly hygroscopic, absorbs moisture from the atmosphere
pH: Typically neutral to slightly alkaline (pH 6.5-8.5)
Specific Gravity: Approximately 1.0-1.2
Optical Rotation: Not applicable
Surface Area: Variable, depending on particle size and morphology


Chemical Properties:

Chemical Formula: (C6H9Na3O6)nq
Molecular Weight: Variable, depending on polymer chain length and degree of cross-linking
Polymer Type: Sodium salt of cross-linked carboxymethyl cellulose
Degree of Substitution: Variable, typically in the range of 0.5-1.0 carboxymethyl groups per glucose unit
Cross-Linking: Cross-linked with divinyl sulfone or other cross-linking agents
Hydrophilicity: Highly hydrophilic, exhibits rapid hydration and swelling in aqueous media
Chemical Stability: Chemically stable under normal storage conditions
Compatibility: Compatible with a wide range of pharmaceutical excipients and active ingredients
Reactivity: Reacts with water to form colloidal dispersions; undergoes reversible hydration and swelling
Hydrolysis: Resistant to hydrolysis under neutral pH conditions; may undergo partial hydrolysis in acidic or alkaline media



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air immediately.
If the person is not breathing, administer artificial respiration.
Seek immediate medical attention and provide the Safety Data Sheet (SDS) or product label to healthcare professionals.
Keep the affected person warm and at rest until medical help arrives.


Skin Contact:

Remove contaminated clothing and shoes immediately.
Wash the affected skin with plenty of soap and water for at least 15 minutes.
If irritation or redness develops, seek medical attention.
If the substance gets into clothing, promptly remove the clothing and rinse the affected skin with water.


Eye Contact:

Flush the eyes with lukewarm water, keeping eyelids open, for at least 15 minutes.
Seek immediate medical attention, and continue flushing the eyes while waiting for medical help.
Remove contact lenses if present and easily removable after flushing.
Do not rub the eyes as this may exacerbate irritation or injury.


Ingestion:

Rinse the mouth thoroughly with water.
Do not induce vomiting unless instructed to do so by medical personnel.
Seek immediate medical attention, and provide the SDS or product label to healthcare professionals.
Do not give anything by mouth to an unconscious person.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including safety goggles or face shield, gloves, and protective clothing, to minimize skin and eye contact.
Use respiratory protection (e.g., NIOSH-approved respirator) if ventilation is inadequate or if there is a risk of inhalation exposure to dust or aerosols.

Ventilation:
Use local exhaust ventilation or ensure adequate general ventilation to control airborne concentrations below recommended exposure limits.
Avoid breathing dust or aerosols generated during handling or processing.

Avoidance of Contact:
Avoid skin contact and inhalation of dust or aerosols.
Wash hands thoroughly after handling, especially before eating, drinking, or using the restroom.
Do not eat, drink, or smoke in areas where croscarmellose sodium is handled.

Spill and Leak Procedures:
In case of a spill or leak, contain the material and prevent further release into the environment.
Avoid creating dust by using vacuum equipment or wet sweeping methods for cleanup.
Dispose of spilled material and contaminated equipment in accordance with local regulations.

Storage:
Store croscarmellose sodium in tightly closed containers in a cool, dry, well-ventilated area.
Protect from moisture and humidity to prevent clumping or caking of the powder.
Keep away from sources of ignition, heat, and direct sunlight.
Store away from incompatible materials, such as strong oxidizers or reducing agents.

Handling Precautions:
Use appropriate engineering controls, such as dust extraction systems or containment enclosures, to minimize dust exposure during handling and processing.
Minimize dust generation by handling croscarmellose sodium in a controlled manner and avoiding unnecessary agitation.
Follow good industrial hygiene practices, including regular cleaning of equipment and work areas to minimize dust accumulation.

Emergency Procedures:
Familiarize personnel with emergency procedures, including spill response, first aid measures, and evacuation protocols.
Ensure that spill control materials, personal protective equipment, and emergency eyewash/shower facilities are readily available and accessible in the handling area.

Training and Awareness:
Provide training to personnel handling croscarmellose sodium on the safe handling procedures, potential hazards, and emergency response protocols.
Ensure that all personnel are aware of the proper storage, handling, and disposal practices to minimize risks and prevent accidents.
Memantine Hcl
SYNONYMS 3,5-dimethyl-1-aminoadamantane hydrochloride;1-Amino-3,5-dimethyltricyclo[3.3.1.1(3.7)] decane hydrochloride; 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride; cas no:19982-08-2 (Base), 41100-52-1 (Hydrochloride)
Menthol
SYNONYMS (+-)-Menthol; 5-Methyl-2-(1-methylethyl)cyclohexanol; (1R,2S,5R)-Menthol; 2-isopropyl-5-methyl-cyclohexanol; Menthyl alcohol; (1 alpha, 2 beta, 5alpha)-5-Methyl-2-(1-methylethyl)cyclohexanol; Hexahydrothymol; Menthol; cis-1,3,trans-1,4-menthol; Menthomenthol; p-Menthan-3-ol; Peppermint Camphor; Racementhol; Racemic menthol; Hexahydrothymol; Menthol racemique; Racementholum; rac-Menthol; (1R,2S,5R)-rel- 5-Methyl-2-(1-methylethyl)cyclohexanol; dl-Menthol; CAS NO. 89-78-1; 15356-70-4(racementhol), 2216-51-5; 98167-53-4(Levomenthol)
Menthol ( D,L-MENTHOL )
Menthol, Cas : 2216-51-5, EC : 218-690-9, Noms français : (-)-MENTHOL; (1R,3R,4S)-(-)-MENTHOL; (L)-MENTHOL; CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1R-(1.ALPHA.,2.BETA.,5.ALPHA.))-; CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1R-(1ALPHA,2BETA,5ALPHA))-; L-MENTHOL MENTHOL, (1R,3R,4S)-(-)-. Le menthol est un composé organique covalent obtenu soit par synthèse, soit par extraction à partir de l'huile essentielle de menthe poivrée ou d'autres huiles essentielles de menthe. Le stéréoisomère le plus courant du menthol est le (–)-menthol, de configuration (1R,2S,5R). Il appartient à la famille des monoterpénols. À température ambiante (20 à 25 °C), il se trouve sous forme de cristaux, d'une couleur blanc cireux. Il fond si l'on augmente légèrement la température. Le menthol a des propriétés anti-inflammatoires et antivirales. Il est d'ailleurs utilisé pour soulager les irritations mineures de la gorge. C'est également un anesthésique local.Le menthol est inclus dans nombre de produits différents pour plusieurs raisons comme : soulagement à court terme de la gorge endolorie et de l'irritation mineure de la bouche ou de la gorge (bains de bouche par exemple) ; antipruritique, pour réduire les démangeaisons ; anesthésique local pour soulager des maux et douleurs mineures telles que des crampes musculaires, entorses, migraines. Il peut être utilisé seul ou combiné à du piment ou du camphre. En Europe, il est plutôt utilisé en gel ou en crème ; décongestionnant pour les voies respiratoires et les sinus ; pesticide contre les acariens (acaricide) ; dans certains médicaments traitant les brûlures mineures, il produit une sensation de froid (souvent utilisés en application locale, en association avec l'aloès) ; additif dans certaines cigarettes, comme saveur, pour réduire l'âcreté, favoriser l'inhalation profonde de la fumée et augmenter l'addiction9 ; additif dans certaines saveurs de liquides pour cigarettes électroniques ; comme désinfectant pour l'hygiène orale, ou remède contre la mauvaise haleine, comme collutoire, dans les pâtes dentifrices, et plus généralement comme agent de saveur pour les chewing-gums et les sucreries ; dans les sodas, aussi bien mélangé avec de l'eau pour obtenir une boisson à très faible teneur en alcool, comme dans le Ricqlès (on fait ici référence à la boisson, et non à l'alcool de menthe de la même marque) ; en versant quelques gouttes d'alcool de menthe sur un morceau de sucre pour soulager la nausée ; pour préparer des esters menthylés afin d'agrémenter des notes florales en parfumerie ; en patchs pour faire tomber la fièvre ou obtenir une sensation de froid (très développé au Japon) ; additif à certains produits de beauté (produits coiffants par exemple). Les défenseurs de l'homéopathie pensent que le menthol interfère avec les produits homéopathiques. Son utilisation est fortement déconseillée en association avec ceux-ci, au point de proscrire les dentifrices à base de menthol. Le menthol peut être utilisé en aromathérapie sous forme d'huile essentielle de menthe poivrée (médecine naturelle), l'indigestion, la nausée, les maux de gorge, la diarrhée, les maux de tête et les refroidissements (médecine orientale).
Menthol ( mentol )
SynonymsMENTHOL;Minclea;L-MENTHOL;FEMA 2665;NSC 62788;uspmenthol;(1R,2S,5R);(-)-MENTHOL;L-MentholuM;L(-)-MENTHOL CAS No.2216-51-5
Menthol crystal
Cyclohexanol, 2-isopropyl-5-methyl; Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-; 3-p-Menthanol; (1R, 2S, 5R)-rel-5-methyl-2-(1-methylethyl)-cyclohexan ol; [1alpha,2beta,5alpha]-5-Methyl-2-isopropylcyc lohexanol; Hexahydrothymol; menthol racemic cas:89-78-1
Menthyl Lactate
[1R-[1.alpha.(R*),2.beta.,5.alpha.]]-5-Methyl-2-(1-methylethyl)cyclohexyl lactate; MENTHYL LACTATE; l-Menthyl lactate; Frescolat; 2-HYDROXY- 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER PROPANOIC ACID, 2-HYDROXYPROPANOIC ACID, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER 2-HYDROXYPROPANOIC ACID, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER PROPANOIC ACID, 2-HYDROXY-, L-MENTHYL LACTATE, LACTIC ACID, P-MENTH-3-YL ESTER, MENTHYL LACTATE, P-MENTH-3-YL ESTER LACTIC ACID, PROPANOIC ACID, 2HYDROXY, 5METHYL2(1METHYLETHYL)CYCLOHEXYL ESTER, [1R[1Ã (R*),2 ,5Ã ]], and [1R-[1ALPHA(R*),2BETA,5ALPHA]]-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL LACTATE CAS NO: 59259-38-0
Mentol
SYNONYMS (+-)-Menthol; 5-Methyl-2-(1-methylethyl)cyclohexanol;;(1R,2S,5R)-Menthol; 2-isopropyl-5-methyl-cyclohexanol; Menthyl alcohol; (1 alpha, 2 beta, 5alpha)-5-Methyl-2-(1-methylethyl)cyclohexanol; Hexahydrothymol; Menthol; cis-1,3,trans-1,4-menthol; Menthomenthol; p-Menthan-3-ol CAS NO: 89-78-1; 15356-70-4(racementhol), 2216-51-5; 98167-53-4(Levomenthol)
Mepyquat Chloride
Ammonium phosphate,monobasic; Phosphoric acid, monoammonium salt; Ammonium biphosphate; Ammonium diacid phosphate; Ammonium dihydrogen phosphate; Ammonium dihydrophosphate; Ammonium monobasic phosphate; Ammonium phosphate; Dihydrogen ammonium phosphate; Monoammonium acid phosphate; Monoammonium dihydrogen phosphate; Monoammonium dihydrogen phosphate; Monoammonium orthophosphate; Monoammonium phosphate; Monobasic ammonium phosphate; Primary ammonium phosphate; Ammonium dihydrogen orthophosphate; cas no: 7722-76-1
MEQUINOL

Mequinol, also known as 4-methoxyphenol, is a chemical compound with the molecular formula C7H8O2.
Mequinol is an aromatic compound and a derivative of phenol where a methyl group is substituted by a methoxy group.
The chemical structure of mequinol consists of a benzene ring (phenol ring) with a hydroxyl group (-OH) and a methoxy group (-OCH3) attached to it.

CAS Number: 150-76-5
EC Number: 205-769-8

1, 4-Methoxyphenol, Hydroquinone monomethyl ether, 1-Hydroxy-4-methoxybenzene, P-Methoxyphenol, 4-Methoxyphenolate, Monomethyl hydroquinone, Mequinol, Methoxyphenol, Monomethylhydroquinone, 4-Methoxy-1-hydroxybenzene, Quinol, 4-Methoxy-1-benzenediol, Monomethyl hydroxybenzene, Benzenediol, 4-methoxy-, p-Oxyanisole, 1,4-Dihydroxy-2-methoxybenzene, 4-Methoxybenzene-1,2-diol, Mequinoli, p-Methoxybenzeneol, p-Oxyanisol, Monomethylhydroxybenzol, NSC 15381, Phenol, 4-methoxy-, p-Methoxybenzenol, FEMA 1437, AI3-00093, BRN 0802958, Caswell No. 593C, FEMA No. 1437, NSC 684250, HSDB 1090, CHEBI:147430, HSDB 6165, p-Methoxybenzenol, Mechinol, Mequitol, 4-Hydroxyanisole, 1-Hydroxy-4-methoxybenzene (Mequinol), Benzenediol, 4-methoxy (9CI), Hydroquinone, monomethyl-, Monomethyl ether hydroquinone, Hydroquinone methyl ether, Methyl hydroquinone, Mequinol (ACGIH), 1,4-Dihydroxy-2-methoxybenzene (Mequinol), UNII-1G4N9R7SSV, 4-Methoxybenzene-1,2-diol (Mequinol), 1,4-Benzenediol, 2-methoxy-, Benzene, 1,4-dihydroxy-2-methoxy-, EINECS 205-769-2, Methyl p-hydroxyphenyl ether, Methoxyhydroquinone, Methoxyquinol, Quinol Mequinol, Quinone, Mequinole, 4-Methoxy-1,2-benzenediol, 1,2-Benzenediol, 4-methoxy-, 4-Methoxybenzenediol, 4-Methoxybenzene-1,2-diol (Mequinol).



APPLICATIONS


Mequinol is widely used in cosmetic formulations for its skin-lightening properties.
In skincare products, Mequinol serves as a key ingredient to address hyperpigmentation and uneven skin tone.
Cosmetic creams and lotions containing Mequinol aim to reduce the appearance of dark spots and melasma.

Mequinol is employed in dermatology for treating conditions related to abnormal skin pigmentation.
Mequinol is a common component in formulations targeting age spots, sun spots, and freckles.
Mequinol-based products are designed to inhibit melanin production, providing a brightening effect on the skin.

Mequinol is often found in skincare serums and treatments dedicated to promoting a more uniform complexion.
Mequinol's applications extend to the treatment of post-inflammatory hyperpigmentation resulting from skin injuries.

Certain medical treatments may incorporate Mequinol to address specific dermatological concerns.
Mequinol-containing formulations may be recommended for individuals with conditions like chloasma or pregnancy-related hyperpigmentation.
In addition to cosmetic uses, Mequinol finds applications in pharmaceutical preparations for dermatological treatments.
Mequinol's effectiveness in inhibiting melanin synthesis makes it valuable in formulations for skin brightening.

Mequinol's application in skincare extends to addressing dark spots caused by exposure to ultraviolet (UV) radiation.
Dermatologists may recommend Mequinol-containing products for patients seeking solutions for skin discolorations.
Mequinol's utility lies in its ability to provide a targeted approach to even out skin tone.

Mequinol may be present in over-the-counter products as well as prescription-based skincare treatments.
Its applications are not limited to facial skincare; Mequinol is used in formulations for various body areas.
Mequinol's use in skincare formulations requires consideration of its stability and compatibility with other ingredients.

Formulations containing Mequinol are subject to regulatory guidelines to ensure their safety in cosmetic and medical use.
Mequinol's applications in skincare align with the growing demand for products addressing pigmentation concerns.
Cosmetic companies often incorporate Mequinol into serums and creams promoting luminosity and radiance.
Mequinol's role in skincare aligns with the broader trend of addressing specific skin concerns with targeted ingredients.

Mequinol-based treatments are considered by individuals seeking solutions for persistent skin discolorations.
Mequinol's applications emphasize its potential to enhance the overall appearance and clarity of the skin.
The use of Mequinol in skincare underscores its significance in formulations dedicated to achieving a more even and radiant complexion.

Mequinol is often included in formulations for cosmetic products designed to address hyperpigmentation caused by various factors.
Dermatologists may recommend Mequinol-containing treatments for patients dealing with skin conditions such as lentigines or liver spots.
Mequinol's utility in reducing the appearance of age-related skin discolorations makes it a sought-after ingredient in anti-aging skincare.

Mequinol's applications extend to skincare regimes targeting dark spots resulting from hormonal changes, such as those during pregnancy.
Certain therapeutic creams and ointments formulated for specific dermatological conditions may include Mequinol as a key component.
Products containing Mequinol are utilized in the treatment of photoaging, addressing skin damage caused by prolonged sun exposure.

Mequinol-based formulations are designed to promote a more youthful and uniform skin tone over time.
In addition to creams and lotions, Mequinol is incorporated into serums, ensuring diverse application methods for consumers.
Mequinol's role in skincare aligns with the growing demand for personalized solutions catering to individual skin concerns.
Mequinol is included in skincare lines focused on providing solutions for stubborn discolorations that affect overall skin clarity.

Mequinol's applications are observed in professional skincare treatments offered by dermatologists and estheticians.
Mequinol's inclusion in skincare regimens highlights its effectiveness in promoting a brighter and more luminous complexion.
Mequinol-containing products may be recommended for individuals with post-inflammatory hyperpigmentation resulting from acne or wounds.
In the field of dermatology, Mequinol plays a significant role in customized treatment plans for patients dealing with pigmentary disorders.

Formulations with Mequinol aim to provide a targeted approach to address specific areas of concern on the face and body.
Mequinol's applications are evident in the formulation of spot treatments designed for precise application on darkened areas.
Skincare routines featuring Mequinol are part of the broader trend of incorporating science-backed ingredients for visible skin improvements.
Mequinol's presence in skincare aligns with the evolving consumer preferences for products with proven efficacy in addressing pigmentation issues.
Mequinol may be utilized in combination with other active ingredients to enhance its overall effectiveness in skincare formulations.

Mequinol-based skincare may be recommended for individuals with persistent discolorations that have not responded to other treatments.
Mequinol's role in skincare emphasizes its contribution to enhancing the overall radiance and evenness of the skin.
Mequinol is used in formulations aimed at revitalizing dull and uneven skin, contributing to a more youthful appearance.
Skincare products featuring Mequinol often undergo rigorous testing to ensure safety and efficacy for diverse skin types.

Mequinol's applications showcase its versatility in various formulations, accommodating different preferences and routines.
Mequinol's inclusion in skincare products reflects ongoing advancements in addressing specific skin concerns and providing tailored solutions.

Mequinol is employed in skincare routines targeting hyperpigmentation caused by sun exposure and environmental factors.
Its applications extend to formulations addressing discolorations associated with aging, promoting a more youthful complexion.
Dermatologists may recommend Mequinol-based treatments for individuals seeking non-invasive solutions for pigmentation concerns.

Mequinol is used in specialized skincare products designed for precise application on localized dark spots.
Mequinol-containing formulations are part of the evolving landscape of advanced skincare for specific skin tone correction.

Products with Mequinol cater to individuals with persistent skin discolorations resistant to conventional treatments.
Mequinol's applications include use in targeted treatments for reducing the appearance of freckles and sun-induced pigmentation.
Mequinol plays a role in skincare innovations addressing uneven skin tone, contributing to a more radiant and uniform complexion.

Mequinol is featured in formulations designed to promote skin clarity and diminish the contrast between dark spots and surrounding skin.
Its presence in skincare aligns with a consumer preference for ingredients backed by scientific research in addressing skin concerns.

Mequinol-based products may be recommended for individuals with skin discolorations caused by hormonal changes, such as those during menopause.
In clinical settings, Mequinol is utilized as part of customized treatment plans for patients with complex pigmentary disorders.
Mequinol's applications are observed in skincare regimes dedicated to improving overall skin texture and luminosity.

Mequinol's role in skincare formulations underscores its potential to contribute to the reduction of stubborn pigmentation issues.
Mequinol is used in the formulation of day and night creams, providing continuous and targeted benefits for improving skin tone.

Mequinol-containing products may be suitable for individuals seeking non-ablative approaches to address melasma and post-inflammatory hyperpigmentation.
Mequinol is incorporated into skincare lines that focus on comprehensive solutions for achieving a balanced and harmonious skin tone.
Mequinol's applications are reflected in its ability to enhance the efficacy of other brightening and clarifying ingredients in skincare formulations.

Skincare products with Mequinol are designed to meet the demand for solutions targeting specific concerns without compromising overall skin health.
Mequinol is used in skincare formulations intended to provide a subtle brightening effect, promoting a natural and healthy-looking complexion.
Mequinol-based treatments may be suggested for individuals with concerns about uneven pigmentation on the face, neck, and décolletage.

Mequinol's role in skincare aligns with advancements in cosmetic science, offering targeted solutions for various skin challenges.
Mequinol-containing products emphasize the importance of consistent and prolonged use for optimal results in addressing pigmentation issues.
Its applications showcase its versatility in catering to a broad spectrum of skin types and ethnicities with diverse pigmentation concerns.
Mequinol's presence in skincare formulations contributes to the ongoing dialogue on inclusivity and personalized solutions for individualized skin needs.

Mequinol is integral to skincare formulations designed to target specific areas of discoloration, providing localized treatment.
Its applications extend to night creams, harnessing the overnight renewal process to address uneven skin tone.
Mequinol-containing products may be included in brightening skincare routines to enhance overall luminosity.

Dermatologists may incorporate Mequinol in personalized treatment plans for patients dealing with complex pigmentation issues.
Mequinol-based formulations play a role in addressing the effects of environmental stressors on skin pigmentation.

Mequinol is featured in serums that deliver concentrated doses of the compound for intense treatment of dark spots.
Mequinol is utilized in skincare innovations targeting not only visible discolorations but also underlying melanin production.

Products with Mequinol may be recommended for individuals with concerns about hyperpigmentation due to genetic factors.
Its presence in targeted spot treatments allows for precise application on specific areas of concern.
Mequinol's applications align with the demand for products that contribute to a more even and radiant complexion.
In formulations for mature skin, Mequinol serves to diminish the appearance of age-related pigmentation changes.

Mequinol-containing creams may be part of comprehensive anti-aging regimens, addressing both texture and tone.
Mequinol is incorporated into skincare products that emphasize long-term benefits for sustained improvement.
Mequinol's applications include use in formulations for body care, extending its benefits beyond facial skincare.

Mequinol is used in daytime moisturizers, contributing to skin protection while addressing pigmentation concerns.
Mequinol's role in skincare formulations highlights its potential to boost overall skin confidence and well-being.
Mequinol's applications are observed in formulations aimed at preventing new discolorations from forming.

Mequinol is utilized in brightening masks, offering an intensive treatment for a more uniform skin tone.
Skincare lines featuring Mequinol cater to individuals seeking solutions for a holistic approach to skin health.
Mequinol-containing products may be recommended for those dealing with post-inflammatory hyperpigmentation from skin trauma.

Mequinol's applications extend to formulations that promote resilience against factors contributing to uneven pigmentation.
Mequinol's presence in skincare aligns with the trend of addressing lifestyle-related factors affecting skin tone.
In formulations for sensitive skin, Mequinol is used judiciously to ensure compatibility and minimal risk of irritation.

Mequinol's applications underscore its versatility, adapting to various product types and formulations.
Its role in skincare aligns with evolving consumer expectations for products that deliver visible and lasting improvements in skin tone and texture.



DESCRIPTION


Mequinol, also known as 4-methoxyphenol, is a chemical compound with the molecular formula C7H8O2.
Mequinol is an aromatic compound and a derivative of phenol where a methyl group is substituted by a methoxy group.
The chemical structure of mequinol consists of a benzene ring (phenol ring) with a hydroxyl group (-OH) and a methoxy group (-OCH3) attached to it.

Mequinol, also known as 4-methoxyphenol, is a chemical compound with a distinct aromatic nature.
Mequinol features a benzene ring with a hydroxyl group and a methoxy group, imparting unique chemical properties.
Mequinol is recognized for its role as a skin-lightening agent used in cosmetic formulations.
Mequinol is a white to light brown crystalline solid with a characteristic odor.

Mequinol has a molecular formula of C7H8O2, reflecting its composition of carbon, hydrogen, and oxygen atoms.
Mequinol is derived from phenol, where a methyl group is substituted by a methoxy group.
The hydroxyl and methoxy groups in Mequinol contribute to its reactivity and solubility in various solvents.

Mequinol is commonly used to treat skin conditions, such as hyperpigmentation and melasma.
In cosmetic products, it acts as a melanin inhibitor, helping to lighten skin tone.
The IUPAC name for Mequinol is 4-Methoxyphenol, describing its chemical structure systematically.
Mequinol exhibits antioxidant properties, contributing to its stability in formulations.

Its chemical structure includes a methoxy group (-OCH3) attached to the aromatic ring, enhancing its biological activities.
Mequinol is known for its ability to interfere with the production of melanin, the pigment responsible for skin coloration.
As a skincare ingredient, Mequinol is often found in creams, lotions, and serums targeting uneven skin tone.

Mequinol is characterized by its solubility in both hot and cold water, making it versatile in cosmetic formulations.
Mequinol's skin-lightening effects are attributed to its impact on the enzyme tyrosinase involved in melanin synthesis.
Mequinol is crucial to use Mequinol-containing products judiciously, following recommended concentrations for safe application.
Mequinol formulations are subject to regulatory guidelines to ensure their safety and efficacy in cosmetic use.

This compound is valued for its hypoallergenic nature, making it suitable for various skincare applications.
Mequinol's use in dermatology extends to the treatment of skin discolorations caused by various factors.
In addition to skincare, Mequinol finds applications in certain industrial processes due to its chemical properties.

Mequinol's molecular structure can be represented as a phenolic ring with substituent groups influencing its biological effects.
When incorporated into cosmetic products, Mequinol aims to provide even skin tone and reduce the appearance of dark spots.
Mequinol's presence in skincare formulations requires careful consideration of its compatibility with other ingredients.
As with any active ingredient, the use of Mequinol in cosmetics should adhere to recommended guidelines and safety standards.



PROPERTIES


Chemical Name: Mequinol
Chemical Formula: C7H8O2
Molecular Weight: Approximately 124.14 g/mol
CAS Number: 150-76-5
Melting Point: Approximately 163-165°C
Boiling Point: Data not available
Appearance: White to off-white crystalline powder
Solubility: Soluble in alcohol and ether, slightly soluble in water.
Odor: Odorless
Density: Data not available
Flash Point: Data not available
Stability: Stable under normal conditions of use and storage.
pH: Data not available
Hygroscopicity: Not reported to be hygroscopic.
Vapor Pressure: Data not available
Refractive Index: Data not available
Surface Tension: Data not available
Viscosity: Data not available
Flammability: Not considered highly flammable.
Toxicity: The compound may cause skin irritation in some individuals; proper handling precautions are recommended.
Biodegradability: Data not available



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
Provide artificial respiration if the person is not breathing.


Skin Contact:

Remove contaminated clothing and footwear.
Wash the affected area with plenty of water and mild soap.
Seek medical attention if irritation or redness persists.
Launder contaminated clothing before reuse.


Eye Contact:

Rinse eyes gently with water for at least 15 minutes, lifting eyelids occasionally.
Seek immediate medical attention if irritation or redness persists.


Ingestion:

Rinse the mouth with water.
Do not induce vomiting unless directed by medical personnel.
Seek immediate medical attention or contact a poison control center.


General First Aid:

If a person shows signs of distress or exhibits symptoms after exposure, seek medical attention promptly.
Provide medical personnel with information on the product and its ingredients.


Notes to Physician:

Treat symptomatically and supportively.
Consider the possible presence of other chemicals if exposure is from a mixture.


Extinguishing Media:

Use extinguishing media suitable for the surrounding fire.
Do not use water directly on the fire.


Fire Fighting:

Wear appropriate protective equipment, including self-contained breathing apparatus (SCBA) and full protective gear.
Evacuate the area if the fire is not controllable.


Accidental Release Measures:

Evacuate the affected area and restrict access.
Wear appropriate personal protective equipment.
Absorb spills with inert materials and place in a suitable container for disposal.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear suitable protective clothing, including gloves, safety goggles, and a lab coat, to prevent skin and eye contact.
Use respiratory protection if handling the compound in an area with inadequate ventilation.

Engineering Controls:
Use local exhaust ventilation to control airborne concentrations, especially in confined spaces.
Ensure adequate general ventilation in the work area.

Hygiene Practices:
Wash hands thoroughly after handling Mequinol.
Do not eat, drink, or smoke in areas where Mequinol is handled.
Avoid touching the face, especially the eyes, nose, and mouth, during and after handling.

Avoidance of Conditions:
Avoid contact with incompatible materials, such as strong acids, bases, and oxidizing agents.
Prevent the formation of dust, vapors, or aerosols during handling.

Storage Compatibility:
Store Mequinol away from incompatible materials in a dedicated storage area.
Keep away from sources of heat, open flames, and direct sunlight.

Handling Procedures:
Use non-sparking tools and equipment to handle Mequinol.
Avoid generating dust and aerosols during handling.

Emergency Procedures:
Be familiar with emergency procedures, including evacuation routes and the location of emergency equipment.
Have access to emergency eyewash stations and safety showers in the vicinity.


Storage:

Storage Conditions:
Store Mequinol in a cool, dry place, away from heat sources and direct sunlight.
Keep containers tightly closed when not in use to prevent contamination and moisture absorption.

Temperature Control:
Ensure storage temperatures are within the recommended range to maintain stability.
Avoid extreme temperatures that may lead to degradation.

Ventilation:
Store Mequinol in a well-ventilated area to prevent the buildup of vapors.
Ensure adequate ventilation in storage rooms and cabinets.

Segregation:
Segregate Mequinol from incompatible materials to prevent chemical reactions.
Clearly label storage areas with appropriate hazard warnings.

Control of Conditions:
Implement measures to prevent spills and leaks, and provide containment for potential releases.
Store Mequinol away from strong acids, bases, and oxidizing agents.

Security Measures:
Restrict access to storage areas to authorized personnel only.
Comply with local regulations regarding the secure storage of hazardous materials.

Inventory Control:
Keep an accurate inventory of Mequinol, noting quantities, dates of receipt, and usage.
Rotate stock to use older material first (FIFO principle).

Monitoring and Inspection:
Regularly inspect containers for signs of damage, leaks, or deterioration.
Monitor storage conditions to ensure compliance with recommended guidelines.
Mera Köpüğü Tohumu Yağı
MEADOWFOAM OIL; meadowfoam seed oil; cropure meadowfoam; limnanthes alba seed oil; oil extracted from the seeds of the meadowfoam plant, limnanthes alba, limnanthaceae CAS NO:169407-13-5
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MARJORAM OIL ; marjoram oil (thymus mastichina) spain; essential oil obtained from the herbs of the thyme, thymus mastichina, lamiaceae; thymus mastichina herb oil spain; marjoram wild spain CAS NO:8016-33-9
MERCAPTO ETHANOL

Mercapto ethanol, also known as 2-Mercapto ethanol or β-Mercapto ethanol, is a chemical compound with the molecular formula C2H6OS.
Mercapto ethanol is classified as a thiol or mercaptan due to the presence of a sulfhydryl (-SH) group in its chemical structure.
Mercapto ethanol has a strong and distinctive odor.
Mercapto ethanol, also known as 2-Mercapto ethanol or β-Mercapto ethanol, is a chemical compound with a unique sulfur-containing structure.

CAS Number: 60-24-2



APPLICATIONS


Mercapto ethanol is widely used in molecular biology and biochemistry laboratories as a reducing agent to break disulfide bonds in proteins.
Mercapto ethanol is an essential component in sample buffers for gel electrophoresis, allowing the separation of proteins and nucleic acids in polyacrylamide or agarose gels.
In Western blotting, Mercapto ethanol helps denature and reduce proteins, making them suitable for detection with specific antibodies.
Mercapto ethanol is employed in protein purification techniques to maintain a reduced environment and prevent protein aggregation.
In cell culture, Mercapto ethanol is added to the medium to create a reducing atmosphere that protects cells from oxidative stress.

Mercapto ethanol plays a vital role in maintaining the integrity and function of enzymes and proteins used in enzymatic assays and studies.
Mercapto ethanol is used in the extraction and isolation of RNA and DNA from biological samples.

Mercapto ethanol is a common reagent for RNA denaturation in Northern blotting procedures.
Mercapto ethanol finds applications in the creation of protein and enzyme solutions for research and diagnostics.
Mercapto ethanol is used to reduce and cleave disulfide bonds in antibodies for improved antigen recognition in immunoassays.

In the pharmaceutical industry, Mercapto ethanol may be utilized for the stabilization and reduction of certain drug compounds.
Mercapto ethanol is employed as a reducing agent in the synthesis of various organic chemicals and pharmaceutical intermediates.
Mercapto ethanol is valuable in chemical reactions requiring the reduction of carbonyl compounds to alcohols.

In the oil and gas industry, it is used as a scavenger for hydrogen sulfide (H2S) to prevent corrosion and souring of crude oil.
Mercapto ethanol serves as a stabilizing agent for certain formulations in the cosmetics and personal care industry.
Mercapto ethanol is employed in the flavor and fragrance industry for its distinct sulfur-based odor profile.
Mercapto ethanol finds use in the creation of specific fragrances and perfumes, contributing to unique scent profiles.

In agriculture, it may be used as a growth regulator and foliar spray in some formulations.
Mercapto ethanol is an important component in the production of specialty chemicals, including dyes and polymers.

In the food industry, it may be used as an antioxidant to preserve the quality of certain food products.
Mercapto ethanol is utilized in the preparation of samples for analytical techniques like mass spectrometry and chromatography.
Mercapto ethanol may serve as a reducing agent in the restoration and conservation of cultural heritage artifacts.
Mercapto ethanol is used in the development of certain adhesives and sealants for industrial and construction applications.

Mercapto ethanol plays a role in the manufacture of specialty coatings and paints for specific applications.
Its versatile reducing properties and applications extend across various scientific, industrial, and research fields, making it a valuable chemical in laboratory and industrial settings.

In the textile industry, Mercapto ethanol is used as a softening agent for fabrics, improving their feel and texture.
Mercapto ethanol serves as a key ingredient in the formulation of certain inkjet printing inks, enhancing color dispersion and print quality.
Mercapto ethanol is employed as a component in industrial paints and coatings, contributing to their adhesion and durability.

Mercapto ethanol plays a role in the production of oilfield chemicals, aiding in processes such as drilling, well stimulation, and oil recovery.
In the pulp and paper industry, it is added to paper coatings to enhance printability and smoothness.
Mercapto ethanol is used in the development of leather treatments and finishes, improving leather quality and appearance.

Mercapto ethanol finds applications in the formulation of adhesive tapes, ensuring strong adhesion to various surfaces.
In electronics manufacturing, it acts as a wetting agent, facilitating soldering and assembly processes.

The food industry utilizes Mercapto ethanol as a processing aid, enhancing the texture and consistency of food products.
In the construction industry, it is used as a concrete release agent to prevent sticking in molds and formwork.
Mercapto ethanol serves as a component in industrial solvents and degreasers for effective cleaning and degreasing applications.

Mercapto ethanol is employed in the production of rust and corrosion inhibitors for metal protection.
In the automotive industry, Mercapto ethanol is added to coolant and antifreeze formulations to prevent corrosion and scale buildup.
Mercapto ethanol is used in ceramic glazes, improving their flow and adhesion to pottery surfaces.

Mercapto ethanol contributes to the formulation of automotive waxes and polishes, enhancing the shine and protection of vehicle finishes.
Mercapto ethanol is utilized in the development of metalworking fluids, improving cutting and machining processes.
Mercapto ethanol is added to rubber tire manufacturing to enhance tire durability and resistance to wear.

In the production of concrete curing compounds, it aids in the proper hydration of concrete surfaces.
Mercapto ethanol is employed as a flotation agent in mineral processing to separate valuable minerals from waste.
Mercapto ethanol serves as a component in asphalt sealants, enhancing their adhesive properties and longevity.

Mercapto ethanol is utilized in the manufacturing of rubber and plastic products, improving processing characteristics and performance.
In the cosmetics industry, it may be used in the formulation of hair and skin care products for various purposes.
Mercapto ethanol plays a role in the creation of specialized lubricants and grease formulations for industrial machinery.

Mercapto ethanol is used in the development of wood preservatives to protect wood against decay and pests.
Mercapto ethanol contributes to the formulation of sludge inhibitors, which are used to control sludge formation in various industrial processes.

In the photography industry, Mercapto ethanol is utilized in developing solutions to reduce silver ions, aiding in the formation of photographic images.
Mercapto ethanol is employed as a reagent in the creation of pharmaceutical intermediates and active ingredients.
Mercapto ethanol serves as a corrosion inhibitor in cooling water systems, protecting metal components from rust and scale formation.

In the manufacturing of detergents and cleaning products, it acts as a stabilizing agent and surfactant.
Mercapto ethanol finds use in the formulation of specialty lubricants for machinery and automotive applications.

Mercapto ethanol is added to air fresheners and deodorizers to mask or neutralize undesirable odors.
Mercapto ethanol is used in the creation of biocides and germicides for disinfection and microbial control.
In the agricultural sector, Mercapto ethanol may be employed as a plant growth regulator.
Mercapto ethanol contributes to the formulation of ink removers and correction fluids, assisting in the removal of ink stains.

Mercapto ethanol is used in the creation of fluxes for soldering and brazing operations.
Mercapto ethanol serves as a reducing agent in the purification of metal ores and minerals.

In the production of rubber goods, it improves the processing characteristics and quality of rubber compounds.
The textile and garment industry uses it in dyeing processes to achieve desired color fastness.
Mercapto ethanol is employed as a stabilizer in the production of hydrogen peroxide.
Mercapto ethanol contributes to the formulation of hair dyes and hair care products, enhancing color retention and manageability.

Mercapto ethanol is used in the manufacturing of specialty chemicals for water treatment.
Mercapto ethanol serves as an antioxidant in the preservation of cosmetics and personal care products.
In the construction industry, it aids in the curing of concrete and mortar to achieve optimal strength and durability.

Mercapto ethanol plays a role in the synthesis of pharmaceutical excipients and drug delivery systems.
Mercapto ethanol is utilized in the creation of lubricating oils and greases for various industrial and automotive applications.
Mercapto ethanol may be added to the formulation of inkjet printer inks to prevent nozzle clogging.
In the woodworking industry, it is used as a wood conditioner to improve stain absorption and finish adhesion.
Mercapto ethanol contributes to the creation of specialty adhesives and sealants for specific bonding requirements.

Mercapto ethanol is employed in the manufacturing of specialty polymers and plastics.
Mercapto ethanol finds applications in the development of specialty chemicals for the petroleum and petrochemical industries.



DESCRIPTION


Mercapto ethanol, also known as 2-Mercapto ethanol or β-Mercapto ethanol, is a chemical compound with the molecular formula C2H6OS.
Mercapto ethanol is classified as a thiol or mercaptan due to the presence of a sulfhydryl (-SH) group in its chemical structure.
Mercapto ethanol has a strong and distinctive odor.

Mercapto ethanol, also known as 2-Mercapto ethanol or β-Mercapto ethanol, is a chemical compound with a unique sulfur-containing structure.
Mercapto ethanol is classified as a thiol due to the presence of a sulfhydryl (-SH) group in its molecular structure.
Mercapto ethanol has a strong and pungent odor, often described as unpleasant and reminiscent of rotten eggs.
Its molecular formula is C2H6OS, and it has a molar mass of approximately 78.13 grams per mole.

The chemical is colorless and typically appears as a clear, odoriferous liquid.
Mercapto ethanol is miscible with water, meaning it can be easily mixed with water in various proportions.

Mercapto ethanol is highly reactive due to the presence of the thiol group, which can undergo oxidation and reduction reactions.
Mercapto ethanol is commonly used in biological and biochemical research as a reducing agent to break disulfide bonds in proteins.

In cell culture, Mercapto ethanol is added to maintain a reducing environment that helps protect cells from oxidative damage.
Mercapto ethanol plays a crucial role in maintaining the integrity and function of proteins in various laboratory applications.
Mercapto ethanol is known for its ability to denature enzymes, making it useful for inactivating unwanted enzymes in experimental procedures.

In chemical synthesis, it serves as a reducing agent in various organic reactions, contributing to the creation of specific chemical compounds.
Due to its strong odor, Mercapto ethanol is often handled with caution and in well-ventilated areas.
Mercapto ethanol has a low boiling point, and its vapors can be harmful when inhaled in high concentrations.
Mercapto ethanol is an essential reagent in many molecular biology techniques, such as gel electrophoresis and Western blotting.

Mercapto ethanol is used in the purification and analysis of nucleic acids and proteins.
In the pharmaceutical industry, Mercapto ethanol may be employed for the stabilization and reduction of certain drug compounds.
Mercapto ethanol's reducing properties make it valuable for maintaining a reduced environment in various chemical reactions.

Mercapto ethanol can be used as a scavenger for reactive oxygen species (ROS) and free radicals.
In diagnostic tests, Mercapto ethanol may be used as a reagent or stabilizing agent in specific assay procedures.

Mercapto ethanol is not only used in laboratories but also has industrial applications, including odor control and corrosion inhibition.
In the oil and gas industry, it is utilized for hydrogen sulfide scavenging and as a chemical additive.
Mercapto ethanol may find applications in the creation of specific flavors and fragrances due to its strong odor.

While its pungent smell can be unpleasant, it is precisely this characteristic that makes it useful in odor control applications.
When working with Mercapto ethanol, proper safety precautions, including the use of personal protective equipment and adequate ventilation, are essential due to its strong odor and reactivity.



PROPERTIES


Chemical Formula: C2H6OS
Molecular Weight: Approximately 78.13 grams per mole


Physical Properties:

Appearance: Clear, colorless liquid
Odor: Strong and pungent, reminiscent of rotten eggs
Boiling Point: Approximately 155-157°C (311-315°F)
Melting Point: Approximately -10°C (14°F)
Density: Approximately 1.114 g/cm³ at 20°C (68°F)
Solubility: Miscible with water and many organic solvents
Vapor Pressure: Negligible at room temperature
Flash Point: Greater than 93°C (199°F)
pH: Neutral (pH 7 in water)
Refractive Index: Approximately 1.502 at 20°C (68°F)


Chemical Properties:

Chemical Classification: Thiol or mercaptan
Functional Group: Sulfhydryl (-SH)
Redox Activity: Strong reducing agent
Reactivity: Highly reactive due to the presence of thiol group
Hygroscopicity: Slightly hygroscopic (absorbs moisture from the air)
Volatile: Evaporates readily at elevated temperatures
Flammability: Non-flammable, but may release toxic fumes when heated



FIRST AID


Inhalation:

If Mercapto ethanol fumes are inhaled and respiratory discomfort occurs, immediately move the affected person to an area with fresh air.
If breathing difficulties persist, seek medical attention promptly.
Provide artificial respiration if the individual stops breathing and is trained personnel or under the guidance of a healthcare professional.


Skin Contact:

In case of skin contact with Mercapto ethanol, promptly remove contaminated clothing and footwear.
Wash the affected skin thoroughly with plenty of soap and water for at least 15 minutes to remove any traces of the chemical.
Seek medical attention if skin irritation, redness, or other adverse reactions occur.
If skin irritation persists, apply a mild, non-alcoholic moisturizer or skin-soothing cream.


Eye Contact:

If Mercapto ethanol comes into contact with the eyes, immediately rinse the affected eye(s) gently with lukewarm water for at least 15 minutes. Hold the eyelids open while rinsing to ensure thorough flushing.
Contact lenses should be removed if present and easy to do so.
Seek immediate medical attention for eye irritation, redness, or discomfort.
Do not rub the eyes, as this may exacerbate irritation.


Ingestion:

If Mercapto ethanol is ingested accidentally, do not induce vomiting unless instructed to do so by medical professionals.
Rinse the mouth with water to remove any remaining chemical.
Seek immediate medical attention, and provide as much information as possible about the ingested quantity and circumstances.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate personal protective equipment, including chemical-resistant gloves, safety goggles or a face shield, a lab coat or protective clothing, and closed-toe shoes, when handling Mercapto ethanol.
Use a laboratory fume hood or work in a well-ventilated area to minimize inhalation exposure.

Avoid Skin and Eye Contact:
Avoid direct skin and eye contact with Mercapto ethanol.
In case of accidental contact, promptly follow the first aid measures provided and remove contaminated clothing.

Odor Control:
Due to its strong odor, handle Mercapto ethanol in areas with proper ventilation or exhaust systems.
The strong odor can be unpleasant and may require additional measures to control.

Labeling:
Ensure that containers holding Mercapto ethanol are clearly labeled with the chemical name, hazard symbols, and appropriate warnings.
Labeling helps prevent accidental exposure and confusion.

No Food or Drink:
Do not eat, drink, or smoke while working with Mercapto ethanol.
Contamination of food or beverages with this chemical can have health risks.

Avoid Mixing:
Do not mix Mercapto ethanol with strong acids, strong bases, or oxidizing agents, as this can lead to hazardous reactions.
Ensure that containers and equipment are free of any incompatible substances.

Spills and Leaks:
In the event of a spill, follow appropriate spill response procedures.
Absorb and neutralize small spills with an appropriate absorbent material, such as vermiculite or diatomaceous earth, and dispose of it as hazardous waste.


Storage:

Container Selection:
Store Mercapto ethanol in containers made of chemically resistant materials, such as glass or high-density polyethylene (HDPE).
Ensure that containers are tightly sealed to prevent vapor release.

Location:
Store Mercapto ethanol in a well-ventilated area away from incompatible materials, including strong acids, strong bases, and oxidizing agents.
Segregate it from substances that can react with or degrade it.

Temperature:
Keep the storage area at a temperature range that prevents excessive heat or cold, as extreme temperatures can affect the stability of the chemical.

Light Protection:
Protect containers from direct sunlight or sources of ultraviolet (UV) light, as exposure to UV radiation can cause degradation.

Flammables:
Keep Mercapto ethanol away from open flames, sparks, or other sources of ignition, as it is non-flammable but can release toxic fumes when heated.

Secure Storage:
Store containers in a stable position to prevent tipping or falling.
Ensure that the storage area is well-organized to prevent accidents and facilitate inventory control.

Safety Data Sheet (SDS):
Maintain access to the Safety Data Sheet (SDS) for Mercapto ethanol in the storage area.
The SDS provides important safety and handling information.

First Aid Equipment:
Keep an eye wash station and emergency shower nearby in case of accidental exposure.



SYNONYMS


2-Mercapto ethanol
β-Mercapto ethanol
2-Hydroxyethanethiol
Ethyl mercaptan
2-Mercaptoethyl alcohol
β-ME
β-Thioethanol
Thioethyl alcohol
Thioglycol
2-Sulfanylethanol
2-Thioethanol
2-Hydroxyethyl mercaptan
Ethylthiol
Ethylene mercaptan
HSCH2CH2OH
β-Hydroxyethyl mercaptan
Mercaptoethyl alcohol
β-Hydroxyethanethiol
Ethanol, 2-mercapto-
β-Monothioglycerol
2-Thioethyl alcohol
2-Thio-1-ethanol
2-Mercapto-1-ethanol
2-Mercaptoethyl hydroxide
Thiohydroxyethyl ether
2-Hydroxyethyl mercaptan
2-Mercaptoethyl hydroxide
2-Mercaptoethylthiol
2-Mercapto-1-ethanol
β-Thiopropionic alcohol
2-Thio-1-ethanol
2-Mercapto ethanolamine
Thioethylene glycol
2-Sulfanyl ethanol
2-Mercaptoethylamine
2-Mercaptoethyl ether
Hydroxyethylthiol
2-Mercaptoethyl alcoholamine
β-Thioethyl hydroxide
2-Sulfur ethanol
Thioethylene alcohol
β-Monothioglycerin
Ethylene sulfhydrate
2-Hydroxyethylthiol
β-Sulfanyl ethanol
HSCH2CH2OH
Ethylthiol alcohol
2-Mercapto ethanol ether
2-Sulfanyl ethyl alcohol
MERCAPTOACETIC ACID
TGA;Thiog;usafcb-35;MEQUINDOX;USAF cb-35;ic acid soL;thioglycolic;thiovanicacid;Thioglycolate;Thiovanic acid CAS NO: 68-11-1
MERCAPTOACETIC ACID (THIOGLYCOLIC ACID)
Mercaptoacetic acid (thioglycolic acid) is the organic compound HSCH2CO2H .
Mercaptoacetic acid (thioglycolic acid) contains both a thiol (mercaptan) and a carboxylic acid.


CAS nUMBER: 68-11-1
EC Number: 200-677-4
MDL Number: MFCD00004876
Linear Formula: HSCH2COOH
Molecular Formula: C2H4O2S



Thiovanic acid, sulfanylacetate, Thioglycolic acid, 2-mercaptoacetate, 2-thioglycolicacid, Thioglycollic acid, 2-thio-glycolicaci, Thioglypollic Acid,
Mercaptoacetic acid, 2-Thioglycolic acid, acidethioglycolique, Acide thioglycolique, Aceticacid,mercapto-, 2-MERCAPTOACETIC ACID, Thioglycolic acid solution, thioglycolic acid free acid, 2-Mercaptoacetic acid, 2-Thioglycolic acid, alpha-Mercaptoacetic acid, Mercaptoacetic acid, Mercaptoessigsaeure,
Mercaptoethanoic acid, Merkaptoessigsaeure, SULFanylacetIC ACID, Thioglykolsaeure, Thioglycolic acid, 2-Mercaptoacetate, 2-Thioglycolate, a-Mercaptoacetate, a-Mercaptoacetic acid, alpha-Mercaptoacetate, Α-mercaptoacetate, Α-mercaptoacetic acid, Mercaptoacetate, Mercaptoethanoate, Sulfanylacetate, Sulphanylacetate, Sulphanylacetic acid, 2-Mercaptoacetate, bismuth (3+), sodium salt (3:1:3), 2-Mercaptoacetate, monoammonium salt, 2-Mercaptoacetate, monopotassium salt, Sodium thioglycolate, 2-Mercaptoacetate, calcium salt (1:1), Ammonium thioglycolate, 2-Mercaptoacetate, calcium salt (2:1), 2-Mercaptoacetate, calcium salt (2:1) salt, trihydrate, Calcium thioglycolate, Sodium thioglycollate, 2-Mercaptoacetate, monosodium salt, 2-Mercaptoacetate, Acetic acid, mercapto-, Thioglycolic acid, 2-Mercaptoacetic acid, 2-Thioglycolic acid, Acetic acid, mercapto-, Acide thioglycolique, Glycolic acid, 2-thio-, Glycolic acid, thio-, Kyselina merkaptooctova, Mercaptoessigsaeure, Thioglycolate, Thioglycollic acid, Thiovanic acid, Acetyl mercaptan, Mercaptoacetate, Mercaptoacetic acid, 2-Mercaptoacetic acid, 2-Thioglycolic acid, mercaptoacetic acid, thioglycolic acid, 68-11-1, 2-Mercaptoacetic acid, 2-Thioglycolic acid, Acetic acid, mercapto-, Sulfanylacetic acid, Thioglycollic acid, 2-sulfanylacetic acid, Thiovanic acid, Mercaptoessigsaeure, Glycolic acid, thio-, Acide thioglycolique, Glycolic acid, 2-thio-, thioglycolicacid, USAF CB-35, 2-Mercaptoacetate, Acetic acid, 2-mercapto-, mercapto acetic acid, mercapto-acetic acid, Mercaptoethanoic acid, alpha-Mercaptoacetic acid, Merkaptoessigsaeure, NSC 1894, .alpha.-Mercaptoacetic acid, NSC-1894, CHEMBL116455, DTXSID8026141, CHEBI:30065, 7857H94KHM, MFCD00004876, DTXCID406141, CAS-68-11-1, HSDB 2702, EINECS 200-677-4, UN1940, BRN 0506166, UNII-7857H94KHM,
AI3-24151, mercaptoactic acid, 2-mercaptoaceticacid, Sulfanylacetic acid #, mercaptoacetic acid (thioglycolic acid), HSCH2COOH, HSCH2CO2H, WLN: SH1VQ,
EC 200-677-4, Thioglycolic acid, >=97%, Thioglycolic acid, >=98%, Thioglycolic acid, >=99%, Thioglycolic Acid (~90%), 4-03-00-00600 (Beilstein Handbook Reference), THIOGLYCOLIC ACID [MI], THIOGLYCOLIC ACID [INCI], Thioglycolic acid, LR, ~80%, CWERGRDVMFNCDR-UHFFFAOYSA-, NSC1894, MERCAPTOACETIC ACID [HSDB],
THIOGLYCOLIC ACID [WHO-DD], THIOGLYCOLLIC ACID [MART.], STR00166, Tox21_201717, Tox21_303306, BDBM50336509, AKOS000118940, DB15429, Thioglycolic acid, for synthesis, 97%, UN 1940, NCGC00249103-01, NCGC00257153-01, NCGC00259266-01, NCI60_001579, Thioglycolic acid [UN1940], FT-0628213, FT-0651867, M0052, NS00003173, EN300-19250, C02086, E78850, Q414738, InChI=1/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4), Sulfanylacetic acid, 2-Sulfanylacetic acid, 2-Mercaptoacetic acid, Acetyl mercaptan, Mercaptoacetate, Mercaptoacetic acid, Thioglycolic acid, Thiovanic acid, mercaptoacetic acid, thioglycolic acid, 2-thioglycolic acid, acetic acid, mercapto, 2-mercaptoacetic acid, sulfanylacetic acid, thiovanic acid, mercaptoessigsaeure, thioglycollic acid, glycolic acid, thio, THIOGLYCOLIC ACID, TGA, 2-MERCAPTOACETIC ACID, MEQUINDOX, thioglycolic, Thioglycolate, THIOGLYCOLLIC ACID, Mercaptoacetate, 2-mercaptoacetate, mercaptoacetic, Acetic acid, 2-mercapto-, Acetic acid, mercapto-, 2-Mercaptoacetic acid, Glycolic acid, 2-thio-, Thiovanic acid, 2-Thioglycolic acid, Thioglycolic acid, α-Mercaptoacetic acid, Mercaptoacetic acid, 2-Mercaptoethanoic acid, Sulfhydrylacetic acid, NSC 1894, TGA, 2-Sulfanylacetic acid, 7283-42-3, 57755-20-1, Mercaptoacetic acid, Thiovanic acid, Thioglycollic acid, Acetomercaptan, Mercaptoacetate, 2-Mercaptoacetic acid, 2-Thioglycolic acid,
Thioglycolic Acid, CAS 68-11-1, Molecular Formula HSCH2COOH,



Mercaptoacetic acid (thioglycolic acid) is the organic compound HSCH2CO2H.
Mercaptoacetic acid (thioglycolic acid) contains both a thiol (mercaptan) and carboxylic acid functional groups.
Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strongly unpleasant odor.


Mercaptoacetic acid (thioglycolic acid) is a clear liquid with a strong unpleasant odor.
Mercaptoacetic acid (thioglycolic acid) is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Mercaptoacetic acid (thioglycolic acid) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.


Mercaptoacetic acid (thioglycolic acid) is the precursor to ammonium thioglycolate that is used for permanents.
Mercaptoacetic acid (thioglycolic acid) is the organic compound HSCH2CO2H .
Mercaptoacetic acid (thioglycolic acid) contains both a thiol (mercaptan) and a carboxylic acid.


Thioglycolic acid (TGA) also known as Mercaptoacetic acid (thioglycolic acid) (CAS 68-11-1) is a high performance chemical containing thiol and carboxylic acid functionality.
Mercaptoacetic acid (thioglycolic acid) is completely miscible in water and generally polar organic solvents.


Mercaptoacetic acid (thioglycolic acid) is miscible with polar organic solvents.
Mercaptoacetic acid (thioglycolic acid) is a reagent that protects tryptophan in amino acid analysis.
Mercaptoacetic acid (thioglycolic acid) is a component of thioglycolate broth, a special bacterial growth media.


Mercaptoacetic acid (thioglycolic acid) is also used in so-called "fallout remover" or "wheel cleaner" to remove iron oxide residue from wheels.
Ferrous iron combines with thioglycolate to form red-violet ferric thioglycolate
Mercaptoacetic acid (thioglycolic acid) is a high-performance chemical containing mercaptan and carboxylic acid functionalities.


Mercaptoacetic acid (thioglycolic acid) is completely miscible in water and in general polar organic solvents.
Mercaptoacetic acid (thioglycolic acid) is a strong reducing agent especially at high pH and forms powerful complexes with metals that give it specific characteristics.


Mercaptoacetic acid (thioglycolic acid) is a sulfur-containing carboxylic acid.
Mercaptoacetic acid (thioglycolic acid) is a conjugate acid of a thioglycolate(1-).
Mercaptoacetic acid (thioglycolic acid) acid is a colorless liquid with a strong unpleasant odor like rotten eggs.


Also known as Mercaptoacetic acid (thioglycolic acid), HSCH2COOH is a colorless liquid with a strong unpleasant odor.
Mercaptoacetic acid (thioglycolic acid) appears as a colorless liquid with an unpleasant odor.
Density of Mercaptoacetic acid (thioglycolic acid) is 1.325 g / cm3.


Mercaptoacetic acid (thioglycolic acid) is used to make permanent wave solutions and depilatories.
Mercaptoacetic acid (thioglycolic acid) has been identified in human blood as reported by (PMID: 31557052 ).
Mercaptoacetic acid (thioglycolic acid) is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives.


Technically Mercaptoacetic acid (thioglycolic acid) is part of the human exposome.
The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health.
An individual's exposure begins before birth and includes insults from environmental and occupational sources.


Mercaptoacetic acid (thioglycolic acid) belongs to the class of organic compounds known as alpha-mercaptocarboxylic acids.
These are carboxylic acids that bear a thiol group at the C-2 position.
Alpha-mercaptocarboxylic acids have the general formula RC(S)C(=O)O, where R = H, organyl group.


Mercaptoacetic acid (thioglycolic acid) is the organic compound HSCH2CO2H.
Mercaptoacetic acid (thioglycolic acid) is often called mercaptoacetic acid (MAA).
Mercaptoacetic acid (thioglycolic acid) is the organic compound HSCH2CO2H.


Mercaptoacetic acid (thioglycolic acid) is often called mercaptoacetic acid (MAA).
Mercaptoacetic acid (thioglycolic acid) contains both a thiol (mercaptan) and carboxylic acid functional groups.
Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strongly unpleasant odor.


Mercaptoacetic acid (thioglycolic acid) is miscible with polar organic solvents.
Mercaptoacetic acid (thioglycolic acid) also known as mercaptoacetic acid (MAA) (CAS 68-11-1) is a high performance chemical containing thiol and carboxylic acid functionality.


Mercaptoacetic acid (thioglycolic acid) is completely miscible in water and generally polar organic solvents.
Mercaptoacetic acid (thioglycolic acid) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Mercaptoacetic acid (thioglycolic acid) is a sulfur-containing carboxylic acid.
Mercaptoacetic acid (thioglycolic acid) is a conjugate acid of a thioglycolate(1-).
Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with an unpleasant odor.


Mercaptoacetic acid (thioglycolic acid) is a water soluble.
Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strong, typical mercaptan disagreeable odor.
Mercaptoacetic acid (thioglycolic acid) contains both a thiol and carboxylic acid functional groups.


Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strongly unpleasant odor.
Mercaptoacetic acid (thioglycolic acid) is miscible with polar organic solvents.
Mercaptoacetic acid (thioglycolic acid) is colorless or slight yellow clarity liquid, with a physical properties as below:


Mercaptoacetic acid (thioglycolic acid) has a melting point -16.5°C, boiling point 123 °C,(3.866KPa), opposite density (d420) 1.2-1.32, refractive index 1.5030, well mixed with water, alcohol and aether, with highly causticity.
Mercaptoacetic acid (thioglycolic acid) is a very good activator and catalyst for epoxy resin and bisphenol A production.


Mercaptoacetic acid (thioglycolic acid) is also the the main material of cosmetics such as cold wave lotion and depilatory.
Mercaptoacetic acid (thioglycolic acid) was first developed in the early 1940s as an active material for cold wave permanents.
Now, Mercaptoacetic acid (thioglycolic acid) and its salts are widely utilized in cosmetic productions and commodities for hair perms, straighteners and depilatories.


Another major use for Mercaptoacetic acid (thioglycolic acid) in its ester form is as a crucial raw material in the production process of organotin heat-stabilizers for PVC.
These esters could be utilzied as chain transfer agents in solvent based polymerizations, too.


Mercaptoacetic acid (thioglycolic acid) is often called mercaptoacetic acid (MAA).
Mercaptoacetic acid (thioglycolic acid) contains both a thiol (mercaptan) and carboxylic acid functional groups.
Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strongly unpleasant odor.


Mercaptoacetic acid (thioglycolic acid) is miscible with polar organic solvents.
Mercaptoacetic acid (thioglycolic acid) is an alternative to 3MPA – 3 mercaptopropionic-acid, a strong reducing agent especially at high pH and a good nucleophilic agent.


Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strong, typical mercaptan disagreeable odor (although olfactory fatigue may occur) which is used in cosmetic formulations including permanent wave solutions and depilatories, in pharmaceutical manufacture, and as a stabilizer for vinyl plastics.


Mercaptoacetic acid (thioglycolic acid) is a member of the thioglycolate chemical class.
Mercaptoacetic acid (thioglycolic acid) is a reactive reducing agent: it is readily oxidized on exposure to air.
Mercaptoacetic acid (thioglycolic acid) is also a weak acid due to the presence of a carboxylic acid function in the molecule.


Because of its high reactivity, Mercaptoacetic acid (thioglycolic acid) is incompatible with air, strong oxidizers, bases, active metals such as sodium, potassium, magnesium, and calcium (for examples).
Mercaptoacetic acid (thioglycolic acid) is considered to be a Class IIIB Combustible Liquid, therefore, it is not considered to be flammable.



USES and APPLICATIONS of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Mercaptoacetic acid (thioglycolic acid) is used to make permanent wave solutions and depilatories.
Mercaptoacetic acid (thioglycolic acid) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.


Mercaptoacetic acid (thioglycolic acid) is the precursor to ammonium thioglycolate that is used for permanents.
Mercaptoacetic acid (thioglycolic acid) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm."


Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Mercaptoacetic acid (thioglycolic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.


Mercaptoacetic acid (thioglycolic acid) is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
Mercaptoacetic acid (thioglycolic acid), usually as its dianion, forms complexes with metal ions.


Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Mercaptoacetic acid (thioglycolic acid) is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Mercaptoacetic acid (thioglycolic acid) is used for the production of bisphenol A epoxy resin.


Mercaptoacetic acid (thioglycolic acid) is the main raw material for cosmetics and hair perm lotion agent.
Mercaptoacetic acid (thioglycolic acid) is used for the synthesis of PVC transparent plastic and organic tin heat stabilizer.
Mercaptoacetic acid (thioglycolic acid) is used Hair removal agent


Mercaptoacetic acid (thioglycolic acid) is used Metal appearance treatment.
Daily usage: Mercaptoacetic acid (thioglycolic acid) is mainly used as raw material of Cold waving agent, widely used as curling agent and also used for depilatory agent.


Pharmaceutical field: Mercaptoacetic acid (thioglycolic acid) is an intermediate for intermediate of cefivitril as well asused for production of carboprost, biotin, thiozinic acid,
Mercaptoacetic acid (thioglycolic acid) is also an important raw material for the synthesis of cysteine, hormonal agent, industrial disinfectant and sulfuric acid.


Oil field: Mercaptoacetic acid (thioglycolic acid) plays the role of corrosion inhibitor in oil field drilling.
Other fields uses of Mercaptoacetic acid (thioglycolic acid): PVC low toxicity or non-toxic stabilizer, metal surface treatmentagent and polymerization initiator, accelerator and chain transfer agent.


Mercaptoacetic acid (thioglycolic acid) is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Mercaptoacetic acid (thioglycolic acid) is the precursor to ammonium thioglycolate, which is used for permanents.

Mercaptoacetic acid (thioglycolic acid) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm".
Alternatively and more commonly, the process leads to depilation, as is done commonly in leather processing.


Mercaptoacetic acid (thioglycolic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolysis reactions are used on condensed tannins to study their structure.


Mercaptoacetic acid (thioglycolic acid) is used as a protecting agent for tryptophan in amino acid analysis and an acidity indicator.
Mercaptoacetic acid (thioglycolic acid) finds application as an intermediate in the chemical reactions such as addition, elimination and cyclization.
Mercaptoacetic acid (thioglycolic acid) acts as a precursor to ammonium thioglycolate, sodium thioglycolate and calcium thioglycolate.


Mercaptoacetic acid (thioglycolic acid)'s organotin derivatives are used as stabilizers for polyvinyl chloride (PVC).
In organic synthesis, Mercaptoacetic acid (thioglycolic acid) acts as a nucleophile in thioglycolysis reactions and sulfur transfer agent for sulfonyl chloride synthesis.


Further, Mercaptoacetic acid (thioglycolic acid) is used in leather processing.
Mercaptoacetic acid (thioglycolic acid) has also been used to soften nails, either to reshape pincer nails into the correct position or to help topical antifungals penetrate the nail.


Organotin derivatives of thioglycolic acid isooctyl esters are widely used as stabilizers for PVC.
These species have the formula R2Sn(SCH2CO2C8H17)2.
Mercaptoacetic acid (thioglycolic acid) is used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.


Mercaptoacetic acid (thioglycolic acid) is used in industries and applications as diverse as cosmetics, oil and gas, polymerization, fine chemistry, leather processing, cleaning, and metals recovery.
Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents.


Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as an S transfer agent for sulfonyl chloride synthesis.
Mercaptoacetic acid (thioglycolic acid) is sensitive reagent for iron, molybdenum, silver, tin.


With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and Mercaptoacetic acid (thioglycolic acid), a yellow precipitate forms.
Mercaptoacetic acid (thioglycolic acid) is used in the manufacture of thioglycolates.


The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory.
The sodium salt also is used in bacteriology in the preparation of thioglycolate media.
Mercaptoacetic acid (thioglycolic acid) is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.


Mercaptoacetic acid (thioglycolic acid) is an intermediate in the production of thiomethoprol (caputril), biotin, thiozinc acid, sodium dithiosuccinate and other pharmaceuticals, and is also an intermediate in the synthesis of cysteine, hormonal agent, and industrial disinfectant.
And an important raw material for the synthesis of sulfuric acid.


Mercaptoacetic acid (thioglycolic acid) is used as antioxidant and stabilizer in pharmaceuticals to enhance the stability of the main drug and prolong the validity period of pharmaceutical preparations.
Mercaptoacetic acid (thioglycolic acid) is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


Mercaptoacetic acid (thioglycolic acid) is used in the following products: cosmetics and personal care products.
Other release to the environment of Mercaptoacetic acid (thioglycolic acid) is likely to occur from: indoor use as processing aid.
Mercaptoacetic acid (thioglycolic acid) is used in the following products: laboratory chemicals and cosmetics and personal care products.


Mercaptoacetic acid (thioglycolic acid) is used in the following areas: scientific research and development.
Other release to the environment of Mercaptoacetic acid (thioglycolic acid) is likely to occur from: indoor use as reactive substance and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).


Mercaptoacetic acid (thioglycolic acid) is used in the following products: leather treatment products and cosmetics and personal care products.
Mercaptoacetic acid (thioglycolic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Mercaptoacetic acid (thioglycolic acid) can occur from industrial use: formulation of mixtures.


Mercaptoacetic acid (thioglycolic acid) is used in the following products: oil and gas exploration or production products.
Mercaptoacetic acid (thioglycolic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Mercaptoacetic acid (thioglycolic acid) is used in the following areas: mining and scientific research and development.


Mercaptoacetic acid (thioglycolic acid) is used for the manufacture of: chemicals.
Release to the environment of Mercaptoacetic acid (thioglycolic acid) can occur from industrial use: of substances in closed systems with minimal release, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).


Release to the environment of Mercaptoacetic acid (thioglycolic acid) can occur from industrial use: manufacturing of the substance.
Ammonium and sodium salts of Mercaptoacetic acid (thioglycolic acid) are mainly used as curling agents, calcium salts can be used as depilatory agents, polymerization initiators, accelerators and chain transfer agents, and can be used for hair removal before cosmetic surgery and animal experiments.


Mercaptoacetic acid (thioglycolic acid) is used to make epoxy resin, catalyst of bisphenol A, and it can also be used as the basic raw material for synthesizing PVC transparent plastic and organic antimony and organic tin heat stabilizer.
Mercaptoacetic acid (thioglycolic acid) is a sensitive reagent for the determination of iron, molybdenum, aluminum, tin, etc., and is an inhibitor of copper sulfide and iron sulfide minerals in beneficiation.


In the petrochemical industry and the railway sector, Mercaptoacetic acid (thioglycolic acid) is used for cleaning and derusting of equipment and rails.
Mercaptoacetic acid (thioglycolic acid) can be used as a crystallization nucleating agent in polypropylene processing and molding, as a modifier for coatings and fibers, as a blanket quickening agent, as a stabilizer raw material for polyvinyl chloride and rubber, as a cold perm agent, and as a pharmaceutical intermediate.


Mercaptoacetic acid (thioglycolic acid) is used as a color developer for the photometric determination of molybdenum, rhenium and iron, and as a compounding masking agent.
Mercaptoacetic acid (thioglycolic acid) is used to make permanent wave solutions and depilatories.


Daily usage: Mercaptoacetic acid (thioglycolic acid) mainly used as raw material of Cold waving agent, widely used as curling agent and also used for depilatory agent.
Pharmaceutical field: Mercaptoacetic acid (thioglycolic acid) is an intermediate for intermediate of cefivitril as well asused for production of carboprost, biotin, thiozinic acid,


Mercaptoacetic acid (thioglycolic acid) is also an important raw material for the synthesis of cysteine, hormonal agent, industrial disinfectant and sulfuric acid.
Oil field: Mercaptoacetic acid (thioglycolic acid) plays the role of corrosion inhibitor in oil field drilling.


Other fields of Mercaptoacetic acid (thioglycolic acid): PVC low toxicity or non-toxic stabilizer, metal surface treatmentagent and polymerization initiator, accelerator and chain transfer agent.
Mercaptoacetic acid (thioglycolic acid) is widely used in the fields of PVC stabilizers, down-hole acidizing, corrosion inhibition in the oil field industry, manufacturing of pharmaceuticals, agrochemicals and dyes, shrink-resistant treatment of wool, fabric dying, leather processing.


Mercaptoacetic acid (thioglycolic acid) is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Mercaptoacetic acid (thioglycolic acid) is the precursor to ammonium thioglycolate that is used for permanents.


Mercaptoacetic acid (thioglycolic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
In fact thioglycolysis reactions, Mercaptoacetic acid (thioglycolic acid) is used on condensed tannins to study their structure.


Mercaptoacetic acid (thioglycolic acid) is mainly used as curling agent, depilatory agent, polyvinyl chloride low-toxic or non-toxic stabilizer, polymerization initiator, accelerator and chain transfer agent, metal surface treatment agent, Pharmaceutical intermediates, important chemical raw materials


Mercaptoacetic acid (thioglycolic acid) is mainly used as raw materials of blanket finishing agent and cold scalding liquid.
Mercaptoacetic acid (thioglycolic acid) is used in the manufacture of liquid medicine.
Mercaptoacetic acid (thioglycolic acid) is used as a reagent and stabilizer for the determination of Iron


Mercaptoacetic acid (thioglycolic acid) is widely used in cosmetics, pharmaceutical, rubber, pesticide, detergent and personal care industries.
Mercaptoacetic acid (thioglycolic acid) is an important intermediate or organic chemical material in the above related product manufacture process.
Mercaptoacetic acid (thioglycolic acid) can also be used as restraining agent for copper sulfide, chemical mineral processing reagent, acid reagent.


Mercaptoacetic acid (thioglycolic acid) may also wok as an important organic reagent for metallic ion such as iron, molybdenum, silver and tin, etc.
Mercaptoacetic acid (thioglycolic acid) is used in Construction chemical as transferring agent , cosmetic formulations including permanent wave solutions and depilatories, in pharmaceutical manufacture, and as a stabilizer for vinyl plastics.
A recent use is as a capping or stabilizing agent for Cd/Te quantum microdots (QDs).


Other usages of Mercaptoacetic acid (thioglycolic acid) are also discovered in the pharmaceutical, agrochemical, leather processing area and industries.
Mercaptoacetic acid (thioglycolic acid) may be used as a water-soluble chain transfer agent for certain acrylic polymers, too.
The anti-corrosive properties of Mercaptoacetic acid (thioglycolic acid) or its salts are very useful in the oil field sector in down-hole applications and as cleaning agents.


-Application Area of Mercaptoacetic acid (thioglycolic acid):
1. Pharmaceutical intermediate;
2. Chain transfer agent for Polycarboxylate Superplasticizer
3. Raw material for PVC tin stabilizers;
4. Concrete admixture.


-Daily Chemical Product Making Area:
Mercaptoacetic acid (thioglycolic acid) is used for manufacturing cold essence and the main raw material of hair removal agent.
In the petroleum chemical industry and railway departments, Mercaptoacetic acid (thioglycolic acid) is used in cleaning equipment and track; The deep processing of products can be made of thioglycolic acid.



MERCAPTOACETIC ACID (THIOGLYCOLIC ACID) ESTERS:
The esters like 2-Ethylhexyl Thioglycolate (-mercaptoacetate) and Iso-Octyl Thioglycolate (-mercaptoacetate), also called IOTG react like regular mercaptans and show long term stability.
Both are important intermediates in the production procedures of tin heat-stabilizers for PVC.



MERCAPTOACETIC ACID (THIOGLYCOLIC ACID) SALTS:
Mercaptoacetic acid (thioglycolic acid)'s salts such as Ammonium Thioglycolate or Monoethanolamine Thioglycolate are widely seen in cosmetics for hair perms and straigtheners.
Calcium Thioglycolate and Potassium Thioglycolate are used in depilatories.



PROPERTIES OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
With its unique reducing properties make Mercaptoacetic acid (thioglycolic acid) an ideal choice for a lot of chemical reactions including addition, elimination, or cyclization reactions.
The thiol group (-SH) in Mercaptoacetic acid (thioglycolic acid) will react in the presence of bases, acids, ketone groups or organic halogens.
In the presence of alcohols or amines, the carboxylic group of Mercaptoacetic acid (thioglycolic acid) will react preferentially.



PRODUCTION OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Mercaptoacetic acid (thioglycolic acid) is prepared by reaction of sodium or potassium chloroacetate with alkali metal hydrosulfide in aqueous medium.
Mercaptoacetic acid (thioglycolic acid) can be also prepared via the Bunte salt obtained by reaction of sodium thiosulfate with chloroacetic acid:
ClCH2CO2H + Na2S2O3 → Na[O3S2CH2CO2H] + NaCl
Na[O3S2CH2CO2H] + H2O → HSCH2CO2H + NaHSO4



REACTIONS OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Mercaptoacetic acid (thioglycolic acid) with a pKa of 3.83 is an acid about 10 times stronger than acetic acid (pKa 4.76):
HSCH2CO2H → HSCH2CO2− + H+
The second ionization has a pKa of 9.3:
HSCH2CO2− → −SCH2CO2− + H+

Mercaptoacetic acid (thioglycolic acid) is a reducing agent, especially at higher pH.
Mercaptoacetic acid (thioglycolic acid) oxidizes to the corresponding disulfide (2-[(carboxymethyl)disulfanyl]acetic acid or dithiodiglycolic acid):
2 HSCH2CO2H + "O" → [SCH2CO2H]2 + H2O



MERCAPTOACETIC ACID (THIOGLYCOLIC ACID), WITH METAL IONS:
Mercaptoacetic acid (thioglycolic acid), usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Mercaptoacetic acid (thioglycolic acid) reacts with diethyl acetylmalonate to form acetylmercaptoacetic acid and diethyl malonate, the reducing agent in the conversion of Fe(III) to Fe(II).



HISTORY OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Scientist David R. Goddard, in the early 1930s, identified Mercaptoacetic acid (thioglycolic acid) as a useful reagent for reducing the disulfide bonds in proteins, including keratin (hair protein), while studying why protease enzymes could not easily digest hair, nails, feathers, and such.
He realized that while the disulfide bonds, which stabilize proteins by cross-linking, were broken, the structures containing these proteins could be reshaped easily, and that they would retain this shape after the disulfide bonds were allowed to re-form.
Mercaptoacetic acid (thioglycolic acid) was developed in the 1940s for use as a chemical depilatory.



ALTERNATIVE PARENTS OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
*Monocarboxylic acids and derivatives
*Alkylthiols
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
*2-mercaptocarboxylic acid
*Monocarboxylic acid or derivatives
*Alkylthiol
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organosulfur compound
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



CHEMICAL PROPERTIES OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Mercaptoacetic acid (thioglycolic acid) is a colorless liquid with a strong unpleasant odor like rotten eggs.
Also known as Mercaptoacetic acid (thioglycolic acid), HSCH2COOH is a colorless liquid with a strong unpleasant odor.
Mercaptoacetic acid (thioglycolic acid) is used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.



SOLUBILITY OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Mercaptoacetic acid (thioglycolic acid) is miscible with water, ethanol, ethers, ketones, esters, chlorinated hydrocarbons, benzene and aromatic hydrocarbons.
Mercaptoacetic acid (thioglycolic acid) is slightly miscible with chloroform.



REACTIVITY PROFILE OF MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
Mercaptoacetic acid (thioglycolic acid) is readily oxidized by air .
Mercaptoacetic acid (thioglycolic acid) reactions with these materials may generate heat and toxic and flammable gases.
Mercaptoacetic acid (thioglycolic acid) may react with acids to liberate hydrogen sulfide.
Mercaptoacetic acid (thioglycolic acid) neutralizes bases in exothermic reactions.
Mercaptoacetic acid (thioglycolic acid) reacts with carbonates and bicarbonates.



PHYSICAL and CHEMICAL PROPERTIES of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
CAS: 68-11-1
Molecular Formula: C2H4O2S
Molecular Weight (g/mol): 92.112
MDL Number: MFCD00004876
InChI Key: CWERGRDVMFNCDR-UHFFFAOYSA-N
ChEBI: CHEBI:30065
IUPAC Name: 2-sulfanylacetic acid
SMILES: C(C(=O)O)S
Chemical formula: C2H4O2S
Molar mass: 92.11 g·mol−1
Appearance: colorless, clear liquid
Odor: strong, disagreeable
Density: 1.32 g/cm3
Melting point: −16 °C (3 °F; 257 K)

Boiling point: 96 °C (205 °F; 369 K) at 5 mmHg
Solubility in water: miscible
Vapor pressure: 10 mmHg (17.8 °C)
Magnetic susceptibility (χ): −50.0·10−6 cm3/mol
CAS number: 68-11-1
EC index number: 607-090-00-6
EC number: 200-677-4
Grade: Reag. Ph Eur
Hill Formula: C₂H₄O₂S
Chemical formula: HSCH₂COOH
Molar Mass: 92.12 g/mol
HS Code: 2930 90 98
Boiling point: 220 °C (1013 hPa) (decomposition)
Density: 1.325 g/cm3
Flash point: 130 °C
Melting Point: -16 °C

pH value: 1.5 (10 g/l, H₂O, 20 °C)
Vapor pressure: 0.5 hPa (25 °C)
Physical state: liquid
Color: colorless
Odor: Stench.
Melting point/freezing point:
Melting point/range: -16 °C
Initial boiling point and boiling range: 96 °C at 7 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Lower explosion limit: 5,9 %(V)
Flash point: 130 °C - closed cup
Autoignition temperature: 315 °C at 1.020 hPa
Decomposition temperature: No data available
pH: 1,5 at 10 g/l at 20 °C

Viscosity
Viscosity, kinematic: 4,69 mm2/s at 20 °C
Viscosity, dynamic: 6,55 mPa.s at 20 °C
Water solubility: 1.000 g/l at 20 °C - completely soluble
Partition coefficient: n-octanol/water:
log Pow: -2,99 at 22 °C - Bioaccumulation is not expected.
Vapor pressure: 0,5 hPa at 25 °C
Density: 1,325 g/cm3
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:
Relative vapor density: 3,18 - (Air = 1.0)

CBNumber:CB6477604
Molecular Formula:C2H4O2S
Molecular Weight:92.12
MDL Number:MFCD00004876
MOL File:68-11-1.mol
Melting point: −16 °C(lit.)
Boiling point: 96 °C5 mm Hg(lit.)
Density: 1.326 g/mL at 20 °C(lit.)
vapor density: 3.2 (vs air)
vapor pressure: 0.4 mm Hg ( 25 °C)
refractive index: n20/D 1.505(lit.)
Flash point: 126 °C
storage temp.: Store at +2°C to +8°C.
solubility: Chloroform (Sparingly), Methanol (Sparingly)
form: Liquid
pka: 3.68(at 25℃)
color: clear clear, colorless

Odor: strong unpleasant odor
PH: 1 (H2O, 20℃)
Water Solubility: soluble
Sensitive: Air Sensitive
Merck: 14,9336
BRN: 506166
Exposure limits TLV-TWA: 1 ppm (~3.8 mg/m3) (ACGIH).
Stability: Air Sensitive
InChIKey: CWERGRDVMFNCDR-UHFFFAOYSA-N
LogP: 0.090
CAS DataBase Reference: 68-11-1(CAS DataBase Reference)
EWG's Food Scores: 3-5
FDA UNII: 7857H94KHM
NIST Chemistry Reference: Acetic acid, mercapto-(68-11-1)
EPA Substance Registry System: Thioglycolic acid (68-11-1)

Molecular Weight: 92.12 g/mol
XLogP3: 0.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 1
Exact Mass: 91.99320054 g/mol
Monoisotopic Mass: 91.99320054 g/mol
Topological Polar Surface Area: 38.3Ų
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 42.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Appearance: Clear colorless Liquid
Infrared spectrum: Conforms
Refractive index: 1.5030 to 1.5050 (20°C, 589 nm)
Titration Iodimetric: ≥97.5 %
Iron (Fe): ≤300 ppb
Impurity: ≤0.2 % Other acids (as TGA)
UV: at 350 nm A: ≤0.01
UV: at 450 nm A: ≤0.01
UV: 1 cm cell vs water

Color scale: ≤10 APHA
Residue after evaporation: ≤0.001 %
Acidity: ≤0.0003 meq/g
Formula: HSCH₂COOH
MW: 92.12 g/mol
Boiling Pt: 220 °C (760 mmHg)
Melting Pt: –16 °C
Density: 1.325 g/cm³
Flash Pt: 126 °C
Storage Temperature: Refrigerator
MDL Number: MFCD00004876
CAS Number: 68-11-1
EINECS: 200-677-4

UN: 1940
ADR: 8,II
Merck Index: 12,09472
Molecular Weight:
92.11700
Exact Mass: 92.12
EC Number: 200-677-4
HScode: 2930909090
PSA:76.10000
XLogP3:0.00080
Appearance:: Thioglycolic acid appears as a colorless liquid with an unpleasant odor.
Density: 1.325 g / cm3.
Density:1.3253 g/cm3 @ Temp: 20 °C
Melting Point:-16.5 °C
Boiling Point:120 °C @ Press: 20 Torr
Flash Point:126ºC
Refractive Index:1.503-1.505

Water Solubility:H2O: soluble
Storage Conditions:2-8ºC
Vapor Pressure:0.4 mm Hg ( 25 °C)
Vapor Density:3.2 (vs air)
Odor:Strong, unpleasant odor
CAS: 68-11-1
EINECS: 200-677-4
InChI: InChI=1/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4)/p-1
InChIKey: CWERGRDVMFNCDR-UHFFFAOYSA-N
Molecular Formula: C2H4O2S
Molar Mass: 92.12
Density: 1.326g/mLat 20°C(lit.)
Melting Point: −16°C(lit.)
Boling Point: 96°C5mm Hg(lit.)
Flash Point: 126 °C
Water Solubility: soluble

Vapor Presure: 0.4 mm Hg ( 25 °C)
Vapor Density: 3.2 (vs air)
Appearance: Liquid
Color: clear clear, colorless
Exposure Limit: TLV-TWA 1 ppm (~3.8 mg/m3) (ACGIH).
Merck: 14,9336
BRN: 506166
pKa: 3.68(at 25℃)
PH: 1 (H2O, 20℃)
Storage Condition: Store at +2°C to +8°C.
Sensitive: Air Sensitive
Refractive Index: n20/D 1.505(lit.)
Physical and Chemical Properties:
The pure product is a colorless transparent liquid,
and the industrial product is colorless to yellowish.

melting point: -16.5 ℃
boiling point: 123 ℃
relative density: 1.3253
refractive index: 1.5030
BR> solubility and water, ethanol and ether are miscible.
Chemical Formula: C2H4O2S
Average Molecular Weight: 92.117
Monoisotopic Molecular Weight: 91.993200062
IUPAC Name: 2-sulfanylacetic acid
Traditional Name: thioglycolic acid
CAS Registry Number: Not Available
SMILES: OC(=O)CS
InChI Identifier: InChI=1S/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4)
InChI Key: CWERGRDVMFNCDR-UHFFFAOYSA-N



FIRST AID MEASURES of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Call a physician immediately.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
Give water to drink (two glasses at most).
Seek medical advice immediately.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system



EXPOSURE CONTROLS/PERSONAL PROTECTION of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: 120 min
*Body Protection:
Acid-resistant protective clothing
*Respiratory protection:
Recommended Filter type: Respirator.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities
*Storage conditions
Tightly closed.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
*Storage stability:
Recommended storage temperature:
2 - 8 °C



STABILITY and REACTIVITY of MERCAPTOACETIC ACID (THIOGLYCOLIC ACID):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .

MERCAPTOPROPIONIC ACID
Mercaptopropionic acid is used as a self-assembled monolayer (SAM) with a thiol and carboxylic groups.
Mercaptopropionic acid has short carbon chains and is mainly used as a capping agent on a variety of nanoparticles.
A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.

CAS: 107-96-0
MF: C3H6O2S
MW: 106.14
EINECS: 203-537-0

Mercaptopropionic acid is an organosulfur compound with the formula HSCH2CH2CO2H.
Mercaptopropionic acid is a bifunctional molecule, containing both carboxylic acid and thiol groups.
Mercaptopropionic acid is a colorless oil.
Mercaptopropionic acid is derived from the addition of hydrogen sulfide to acrylic acid.

Mercaptopropionic acid Chemical Properties
Melting point: 15-18 °C (lit.)
Boiling point: 110-111 °C/15 mmHg (lit.)
Density: 1.218 g/mL at 25 °C (lit.)
Vapor pressure: 0.04 mm Hg ( 20 °C)
Refractive index: n20/D 1.492(lit.)
FEMA: 4587 | 3-MERCAPTOPROPIONIC ACID
Fp: 201 °F
Storage temp.: Store below +30°C.
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: pK1:;pK2:10.84(SH) (25°C)
Form: Crystalline Powder, Crystals, and/or Chunks
Color: White
Specific Gravity: 1.218
PH: 2 (120g/l, H2O, 20℃)
Odor: sulfurous roasted
Odor Type: sulfurous
Explosive limit: 1.60%(V)
Water Solubility: soluble
Sensitive: Air Sensitive & Hygroscopic
JECFA Number: 1936
BRN: 773807
Stability: Air Sensitive, Hygroscopic
InChIKey: DKIDEFUBRARXTE-UHFFFAOYSA-N
LogP: -2.3 at 22℃
CAS DataBase Reference: 107-96-0(CAS DataBase Reference)
NIST Chemistry Reference: Mercaptopropionic acid (107-96-0)
EPA Substance Registry System: Mercaptopropionic acid (107-96-0)

Reactions and uses
Mercaptopropionic acid is competitive inhibitor of glutamate decarboxylase, and therefore acts as a convulsant.
Mercaptopropionic acid has higher potency and faster onset of action compared to allylglycine.
Mercaptopropionic acid is used to prepare hydrophilic gold nanoparticles, exploiting the affinity of gold for sulfur ligands.

Uses
Mercaptopropionic acid is widely used in food and beverage industries as a flavoring agent.
Mercaptopropionic acid is used in the production of PVC stabilizers, which are used as chain transfer agents in polymerizations.
Mercaptopropionic acid can be used as primary or secondary, color stabilizer in combination with phenolic antioxidant for polymers.
Mercaptopropionic acid acts as a sulfide ion equivalent and is utilized in the preparation of diaryl sulfide from aryl iodide.

Synonyms
3-MERCAPTOPROPIONIC ACID
107-96-0
3-Mercaptopropanoic acid
3-Sulfanylpropanoic acid
3-Thiopropionic acid
3-Thiopropanoic acid
beta-Mercaptopropionic acid
Mercaptopropionic acid
Propanoic acid, 3-mercapto-
3MPA
2-Mercaptoethanecarboxylic acid
beta-Thiopropionic acid
Hydracrylic acid, 3-thio-
Propionic acid, 3-mercapto-
Thiohydracrylic acid
NSC 437
.beta.-Thiopropionic acid
.beta.-Mercaptopropionic acid
3-Thiolpropanoic acid
3-thiohydracrylic acid
3-Mercaptopropionicacid
3-mercapto-propionic acid
B03TJ3QU9M
.beta.-Mercaptopropanoic acid
CHEMBL358697
DTXSID8026775
CHEBI:44111
NSC-437
beta-Mercaptopropanoic acid
UNII-B03TJ3QU9M
Propionic acid, 3-mercpato-
HSDB 5381
3 Mercaptopropionic Acid
EINECS 203-537-0
MFCD00004897
Mercaptopropionic acid, 3-
BRN 0773807
AI3-26090
BMPA
DEAMINO CYSTEINE
ss--Thiopropionic acid
betamercaptopropionic acid
3-mercapto-propanoic acid
ss--Mercaptopropanoic acid
ss--Mercaptopropionic acid
EC 203-537-0
3-Sulfanylpropanoic acid #
SCHEMBL7289
4-03-00-00726 (Beilstein Handbook Reference)
3-Mercaptopropanoic acid, 9CI
DTXCID106775
NSC437
3-Mercaptopropionic acid, 98%
FEMA NO. 4587
3-Mercaptopropionic acid, >=99%
AMY27767
BCP16636
STR01222
Tox21_200194
BDBM50121953
MERCAPTOPROPIONIC ACID [INCI]
STL281859
Thiopropionic acid; 3-Thiopropanoic acid; beta-Mercaptopropionic acid
AKOS000121541
AC-4722
AT21041
SB66313
3-MERCAPTOPROPIONIC ACID [HSDB]
NCGC00248556-01
NCGC00257748-01
BP-21405
CAS-107-96-0
FT-0615955
FT-0658630
M0061
3-Mercaptopropionic acid, >=99.0% (HPLC)
EN300-19579
3-Dimethylamino-2-methylpropylchloridehydrochloride
A801785
J-512742
Q11751618
F2191-0215
Z104474322
InChI=1/C3H6O2S/c4-3(5)1-2-6/h6H,1-2H2,(H,4,5
68307-97-1
MERCAPTOPROPIONIC ACID
DESCRIPTION:
Mercaptopropionic acid is an organosulfur compound with the formula HSCH2CH2CO2H.
Mercaptopropionic acid is a bifunctional molecule, containing both carboxylic acid and thiol groups.
Mercaptopropionic acid is a colorless oil.
Mercaptopropionic acid is derived from the addition of hydrogen sulfide to acrylic acid.

CAS Number: 107-96-0
EC Number: 203-537-0

Mercaptopropionic acid is used as a self-assembled monolayer (SAM) with a thiol and carboxylic groups.
Mercaptopropionic acid has short carbon chains and is mainly used as a capping agent on a variety of nanoparticles.

Mercaptopropionic acid is a mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.
Mercaptopropionic acid has a role as an algal metabolite.
Mercaptopropionic acid is a conjugate acid of a 3-mercaptopropionate.

Mercaptopropionic acid is a natural product found in Synechococcus elongatus, Brassica napus, and Bos taurus with data available.
Mercaptopropionic acid is An inhibitor of glutamate decarboxylase.
Mercaptopropionic acid decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.


Mercaptopropionic acid is an organic compound.
Mercaptopropionic acid exists as a colourless liquid that demonstrates solubility in both water and organic solvents.
As a sulfur-containing carboxylic acid and a derivative of propionic acid, Mercaptopropionic acid serves as a crucial precursor for the synthesis of various organic compounds, making it invaluable across scientific and industrial applications.

In scientific research, Mercaptopropionic acid finds widespread usage as a reagent in organic synthesis and in the production of proteins and other biomolecules.
Mercaptopropionic acid also functions as a chelating agent, adept at binding metal ions within aqueous solutions, and plays a vital role as a stabilizing agent in polymer production.



REACTIONS AND USES OF MERCAPTOPROPIONIC ACID:
Mercaptopropionic acid is competitive inhibitor of glutamate decarboxylase, and therefore acts as a convulsant.
Mercaptopropionic acid has higher potency and faster onset of action compared to allylglycine.
Mercaptopropionic acid is used to prepare hydrophilic gold nanoparticles, exploiting the affinity of gold for sulfur ligands


APPLICATIONS OF MERCAPTOPROPIONIC ACID:
Mercaptopropionic acid is used to produce hydrophilic SAMs, which are terminated with carboxylic acids and can be further functionalized to introduce more complex end groups such as enzymes for biosensor applications.
SAMs of Mercaptopropionic acid are capped on ZnSe quantum dots for the electrochemical detection of dopamine.

Mercaptopropionic acid is used as a capping agent on CdTe quantum dot nanocrystals (QD NCs) for use as labeling materials in biomedical applications.
Mercaptopropionic acid can also be used to modify the surface of iron oxide nanoparticles (Fe2O3) in the extraction and preconcentration of Al3+ and Cr3+ ions from different biological samples








CHEMICAL AND PHYSICAL PROPERTIES OF MERCAPTOPROPIONIC ACID:
Chemical formula C3H6O2S
Molar mass 106.14 g•mol−1
Density 1.218
Melting point 16.9 °C (62.4 °F; 290.0 K)
Boiling point 111 °C (232 °F; 384 K)
Solubility in water soluble
Solubility ether
benzene
alcohol
water
Acidity (pKa) 4.34
Refractive index (nD) 1.4911 at 21 °C
vapor pressure: 0.04 mmHg (20 °C)
Quality Level: 200
Assay: ≥99%
Form: liquid
autoignition temp.: 662 °F
refractive index
n20/D 1.492 (lit.)
bp: 110-111 °C/15 mmHg (lit.)
Mp: 15-18 °C (lit.)
Density: 1.218 g/mL at 25 °C (lit.)
Boiling point 110 °C (20 hPa)
Density 1.22 g/cm3 (20 °C)
Explosion limit 1.60 %(V)
Flash point 93.4 °C
Ignition temperature 350 °C
Melting Point 17 - 19 °C
pH value 2 (120 g/l, H₂O, 20 °C)
Vapor pressure 0.022 hPa (20 °C)
CAS number 107-96-0
EC number 203-537-0
Hill Formula C₃H₆O₂S
Chemical formula HSCH₂CH₂COOH
Molar Mass 106.14 g/mol
HS Code 2930 90 98




SAFETY INFORMATION ABOUT MERCAPTOPROPIONIC ACID:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product








SYNONYMS OF MERCAPTOPROPANOIC ACID:

3 Mercaptopropanoic Acid
3 Mercaptopropionic Acid
3-Mercaptopropanoic Acid
3-Mercaptopropionic Acid
Acid, 3-Mercaptopropanoic
Acid, 3-Mercaptopropionic
beta Mercaptopropionate
beta-Mercaptopropionate
3-MERCAPTOPROPIONIC ACID
107-96-0
3-Mercaptopropanoic acid
3-Sulfanylpropanoic acid
3-Thiopropionic acid
3-Thiopropanoic acid
beta-Mercaptopropionic acid
Mercaptopropionic acid
Propanoic acid, 3-mercapto-
3MPA
2-Mercaptoethanecarboxylic acid
beta-Thiopropionic acid
Hydracrylic acid, 3-thio-
Propionic acid, 3-mercapto-
Thiohydracrylic acid
beta-Mercaptopropanoic acid
NSC 437
.beta.-Thiopropionic acid
UNII-B03TJ3QU9M
.beta.-Mercaptopropionic acid
C3H6O2S
Propionic acid, 3-mercpato-
3-Thiolpropanoic acid
3-thiohydracrylic acid
3-Mercaptopropionicacid
HSDB 5381
EINECS 203-537-0
3-mercapto-propionic acid
Mercaptopropionic acid, 3-
BRN 0773807
B03TJ3QU9M
.beta.-Mercaptopropanoic acid
AI3-26090
CHEMBL358697
DTXSID8026775
CHEBI:44111
NSC-437
EC 203-537-0
4-03-00-00726 (Beilstein Handbook Reference)
beta-Mercaptopropionate
3 Mercaptopropionic Acid
MFCD00004897
3-mercaptopropionsyre
BMPA
DEAMINO CYSTEINE
ss--Thiopropionic acid
betamercaptopropionic acid
3- mercaptopropionic acid
3-mercapto-propanoic acid
Propionic acid, mercapto-
ss--Mercaptopropanoic acid
ss--Mercaptopropionic acid
3-Sulfanylpropanoic acid #
SCHEMBL7289
USAF E-5
3-Mercaptopropanoic acid, 9CI
DTXCID106775
NSC437
3-Mercaptopropionic acid, 98%
FEMA NO. 4587
3-Mercaptopropionic acid, >=99%
AMY27767
BCP16636
STR01222
Tox21_200194
BDBM50121953
MERCAPTOPROPIONIC ACID [INCI]
STL281859
Thiopropionic acid; 3-Thiopropanoic acid; beta-Mercaptopropionic acid
AKOS000121541
AC-4722
AT21041
SB66313
3-MERCAPTOPROPIONIC ACID [HSDB]
propionic acid, 3-mercapto-methyl ester
NCGC00248556-01
NCGC00257748-01
BP-21405
CAS-107-96-0
LS-124729
LS-124730
FT-0615955
FT-0658630
M0061
3-Mercaptopropionic acid, >=99.0% (HPLC)
EN300-19579
3-Dimethylamino-2-methylpropylchloridehydrochloride
A801785
J-512742
Q11751618
F2191-0215
Z104474322
InChI=1/C3H6O2S/c4-3(5)1-2-6/h6H,1-2H2,(H,4,5
68307-97-1
3-Mercaptopropionic acid
107-96-0 [RN]
203-537-0 [EINECS]
2-mercaptoethanecarboxylic acid
3-mercaptopropanoic acid
3-Sulfanylpropanoic acid [ACD/IUPAC Name]
3-Sulfanylpropansäure [German] [ACD/IUPAC Name]
3-thiopropionic acid
4-03-00-00726 [Beilstein]
773807 [Beilstein]
Acide 3-sulfanylpropanoïque [French] [ACD/IUPAC Name]
B03TJ3QU9M
Hydracrylic acid, 3-thio-
mercaptopropionic acid
MFCD00004897 [MDL number]
Propanoic acid, 3-mercapto- [ACD/Index Name]
SH2VQ [WLN]
UF5270000
UNII-B03TJ3QU9M
β-Mercaptopropanoic acid
β-mercaptopropionic acid
β-Mercaptopropionic acid
β-thiopropionic acid
β-Thiopropionic acid
??-mercaptopropionic acid
203-537-0MFCD00004897
3-Mercapto Propionic Acid
3-Mercaptopropanic Acid
3-mercaptopropanoate
3-mercapto-propanoic acid
3-Mercaptopropanoic acid, 9CI
3-Mercaptopropionic acid-
3-Mercapto-propionic acid
3-Mercaptopropionic Acid (en)
3MPA
3-MPA
3-thiohydracrylic acid
3-thiolpropanoic acid
3-Thiopropanoic acid
propionic acid, 3-mercapto-
propionic acid, mercapto-
ß-mercaptopropionic acid
STR01222
T5SJ B1 C1 DVQ E- AT5NJ [WLN]
Thiohydracrylic acid
UNII:B03TJ3QU9M
β-Mercaptopropanoic acid
β-Mercaptopropionate
β-mercaptopropionic acid



MERGAL BIT 20
MERGAL BIT 20 is an effective broad-spectrum liquid preservative designed to inhibit the growth of micro-organisms such as bacteria, yeast, and fungi in aqueous based formulations Mergal BIT 20 by Troy Corporation acts as a biocide. Based on BIT chemistry and compatible over a wide pH range. Mergal BIT 20 is heat stable and formaldehyde-free. Mergal BIT 20 offers high pH formulations and is compatible with amines as well as amine containing additives. Mergal BIT 20 is designed to inhibit the growth of microorganisms such as bacteria, yeast, and fungi in aqueous based formulations. MERGAL BIT20 For Industrial Use Only As A Microbiostat Preservative Intended To Protect Adhesives, Building And Construction Compositions, Emulsion Paint And Coatings, Inks, Lattices, Leather Processing Solutions, Metalworking Fluids, Mineral Slurries And Dispersions, Oil Recovery Systems, Paper Coatings, Pesticide Formulations, Polymer Emulsions, Textile Spin-Finish And Coatings, Car Care Products Including Car Washes, Car Waxes And Silicone Emulsions, Home Care Cleaning Products Including Floor Cleaners, Floor Waxes, Floor Polishes And Surface Cleaners, Laundry Additives Including Liquid Laundry Detergents, Fabric Softeners And Stain Removers. ACTIVE INGREDIENT: ....................................... % Weight 1,2-Benzisothiazolin-3(2H)-one ............................. 19.18% INERT INGREDIENTS ............................................. 80.82% TOTAL ................................................................... 100.00% GENERAL INFORMATION APPLICATION RATE: Mergal BIT20 is an effective preservative for most aqueous applications. Mergal BIT20 is used in aqueous or water-containing products and systems to control growth of bacteria and fungi. Use rates are in percentage by weight and refer to the product Mergal BIT20. In order to determine the most cost effective use level for Mergal BIT20 in a given use, field trials are suggested. GENERAL RECOMMENDATIONS: For protection against bacterial attack, a concentration within the range of 0.02 – 0.35% of this product is almost invariably sufficient. The control of mold growth, particularly on paste products of high solids content, may occasionally demand dosages above 0.25%. In dilute fluid systems, spoilage is usually controlled with dosages not greater than 0.09%. The use rate is 0.05 – 0.25% wt/wt in the following products: Adhesives, Building and Construction Compositions, Emulsion Paint and Coatings, Inks, Lattices, Leather Processing Solutions, Metalworking Fluids, Mineral Slurries and Dispersions, Paper Coatings, Pesticide Formulations, Polymer Emulsions, Textile Spin-Finish and Coatings. Mergal BIT20 is approved for adhesives used in food packaging and food contact paper and paperboard coatings. Use of Mergal BIT 20 must not exceed 0.21 mg/in2 (0.0326 mg/cm2) of finished paper and paperboard intended for contact with dry foods and 0.11 mg/in2 (0.0168 mg/cm2) of finished paper and paperboard intended for contact with aqueous and fatty foods. Oil Recovery Systems: Drilling fluids, packer fluids, completion fluids: Polysaccharide fluid loss control agents and thickeners such as starch, guar, and xanthan gum at a use rate of 0.05 – 0.15% on fluid weight or 1.5 – 4.5% on the dry polysaccharide eight. Subsurface injection waters such as polymer and micellar/polymer waterfloods: Thickeners such as polysaccharides and xanthan gum at a use rate of 0.05 – 0.15% on the solution weight. . GENERAL INFORMATION APPLICATION RATE: Mergal BIT20 is an effective preservative for most aqueous applications. Mergal BIT20 is used in aqueous or water-containing products and systems to control growth of bacteria and fungi. Use rates are in percentage by weight and refer to the product Mergal BIT20. In order to determine the most cost effective use level for Mergal BIT20 in a given use, field trials are suggested. The use rate is 0.05 – 0.3% wt/wt in the following products: Car Washes, Car Waxes And Silicone Emulsions, Home Care Cleaning Products Including Floor Cleaners, Floor Waxes, Floor Polishes And Surface Cleaners, Laundry Additives Including Liquid Laundry Detergents, Fabric Softeners And Stain Removers. Mergal BIT20 is an effective broad-spectrum, liquid preservative designed to inhibit the growth of microorganisms such as bacteria, yeast, and fungi in aqueous based formulations. GENERAL INFORMATION APPLICATION RATE: Mergal BIT20 is an effective preservative for most aqueous applications. Mergal BIT20 is suggested for use in aqueous or water-containing products and systems to control growth of bacteria and fungi. In order to determine the most cost effective use level for Mergal BIT20 in a given use, field trials are suggested. GENERAL RECOMMENDATIONS: For protection against bacterial attack, a concentration within the range of 0.02 – 0.35% of this product is almost invariably sufficient. The control of mold growth,particularly on paste products of high solids content, may occasionally demand dosages above 0.25%. In dilute fluid systems, spoilage is usually controlled with dosages not greater than 0.09%. The use rate is 0.05-0.35% wt/wt of Mergal BIT20 in the following products: Adhesives, Building and Construction Compositions, Emulsion Paint and Coatings, Inks, Latices, Leather Processing Solutions, Metalworking Fluids, Mineral Slurries and Dispersions, Paper Coatings, Pesticide Formulations, Polymer Emulsions, Textile Spin-Finish And Coatings. Mergal BIT20 is approved for adhesives used in food packaging and food contact paper and paperboard coating. Use of Mergal BIT20 must not exceed 0.21 mg/in2(0.0326 mg/cm2) offinished paper and paperboard intended for contact with dry foods and 0.11 mg/in2(0.0168mg/cm2) of finished paper and paperboard intended for contact with aqueous and fatty foods. OIL RECOVERY SYSTEMS: Drilling fluids, packer fluids, completion fluids. Polysaccharide fluid loss control agents and thickeners such as starch, guar, and xanthan gum-0.05-0.15% on fluid weight or 1.5-4.5 on the dry polysaccharide weight. Subsurface injection waters such as polymer and micellar/polymer waterfloods: Thickeners such as xanthan gum and polysaccharides-0.05-0.15% on solution weight. SUPPLEMENTAL DOSING: Depending on the nature/severity of the contamination, if analysis indicates a loss of active ingredient and further microbial control is necessary, product may be dosed with additional microbiocide at a level to ensure that the final use-dilution product will not exceed the maximum concentration indicated METALWORKING FLUID ADDITIVES DIVISION MERGAL BIT 20 EPA Registration No. 5383-121 Description Application/ Use Highlights Physical Properties Antimicrobial Activity Water dilutable soluble oil, semi-synthetic and synthetic metalworking fluid systems are highly susceptible to the growth of microorganisms. Microbial contamination can result in slime generation, gas formation, malodors and the reduction or drift of pH in the fluid concentrate and the working dilution. This contamination can diminish fluid performance and system efficiency, which can increase costs, decrease tool life, reduce productivity and cause machine shut-down. The use of Mergal BIT20, a proven high quality preservative to control biodeterioration, will help maintain product functionality and increase the life of the metalworking fluid. For use in concentrates during manufacturing and in post addition applications. • Cost effective • Excellent pH stability • Formaldehyde free • Broad spectrum of activity • Outstanding stability in the presence of amines or high heat • Ease of incorporation • Excellent freeze-thaw stability, low freezing point • Long-term efficacy The following are typical properties of Mergal BIT 20; they are not to be considered product specifications. Active Ingredient, 1,2-Benzisothiazolin-3-one: 19.3% Appearance: Clear liquid Specific Gravity, 25°C: 1.13 Lbs/Gal: 9.42 (approx.) Viscosity (Brookfield), 25°C: 400 pH (10% aqueous room temperature solution): ~12 Flash Point (ASTM D3278-96) >94°C (>200°F) Solubility: Soluble in water at use dilutions Gram Negative Bacteria Gram Positive Bacteria Proteus vulgaris Bacillus subtilis Desulfovibrio desulfuricans Staphylococcus aureus Enterobacter aerogenes Streptococcus faecalis Escherichia coli Pseudomonas aeruginosa Function/ Activity Formulating Considerations Regulatory Considerations Environmental Effects Mergal BIT20 is a liquid, organic broad spectrum preservative designed for use in both the concentrate and working dilutions of soluble oil, semi-synthetic and synthetic metalworking fluid systems which may be subject to microbial degradation. Mergal BIT20, at appropriate use levels in both laboratory and field evaluations, inhibits the growth of microorganisms. Products protected with Mergal BIT20 can generally resist the long-term, repeated challenge of microorganisms. When used in metalworking fluid concentrates and working dilutions at application use levels of up to 0.15% (max.), based on the weight of the working dilution, Mergal BIT20 will protect against a broad range of gram positive and gram negative bacteria and other microorganisms. The level of Mergal BIT20 required for optimum effectiveness is dependant on the composition and end use application of your specific product formulation. Mergal BIT20 may be used in systems with commonly used fungicides such as Troyshield LA33, Troyshield FX20 and Troyshield FX40. Customers are encouraged to check for compatibility and stability in their formulated systems. Acute Oral Effects: LD50 (oral, rat, female) – 1020 mg/kg Acute Skin Effects: LD50 (dermal, rabbit) > 2000 mg/kg. Moderate irritation (rabbit). This product is not a skin sensitizer. Acute Eye Effects: Severe irritation and corrosive (rabbit). Corneal damage may be irreversible if not washed from eyes promptly. Acute Inhalation Effects: LD50 (rate, 4 hr.) – 0.57 mg/l. Subchronic Effects and Other Studies Additional data is available on request from the Troy Chemical Corporation on active ingredient and other hazardous components. Ecotoxicity This product is moderately toxic to fish. Do not apply directly to water or wetlands. Do not contaminate water when disposing of equipment washwaters. Data on the active ingredient, 1,2,-Benzisothiazolin-3-one (BIT), is as follows: LC50 (rainbow trout, 96 hr flow-through): 1.3-1.6 mg/kg. LC50 (water flea, 48 hr flow-through): 1.5-3.3 mg/kg. Environmental Fate 1,2,-Benzisothiazolin-3-one (BIT) is hydrolytically stable (half-life >30 days), but breaks down fairly quickly in aerobic soils (half-life <24 hours in sandy loam soil). Its low Kow (20 at 25°C) indicates that it is unlikely to bioaccumulate in aquatic organisms. Chemical Inventories Labeling Handling, Storage, Health And Safety Shipping And This product, or its components, are listed on, or are exempt from: Country Agency CAS or Other Identification Number United States TSCA 2634-33-5 (CAS No.) United States EPA 5383-121 Canada DSL 2634-33-5 (CAS No.) Europe EINECS 220-120-9 Switzerland SWISS G-6729 Australia AICS 2634-33-5 (CAS No.) Korea ECL 2634-33-5 (CAS No.) Korea ECL Serial No. KE-02680 Japan ENCS 2634-33-5 (CAS No.) Japan MITI No. 9-1845 Philippines PICCS 2634-33-5 (CAS No.) China IECSC 2634-33-5 (CAS No.) HAZARDS TO HUMANS AND DOMESTIC ANIMALS. DANGER: Corrosive. Causes irreversible eye damage. Harmful if swallowed, inhaled, or, absorbed through skin. Do not get in eyes, on skin or on clothing. Avoid breathing vapor or spray mist. Wear goggles, face shield, or safety glasses. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. Remove and wash contaminated clothing before reuse. Avoid contact with skin, eyes, or clothing. Avoid breathing vapor or mist. Wash thoroughly after handling. Keep container tightly closed. Use only with adequate ventilation. Store away from incompatible substances in a cool dry, ventilated area. Do not store near food or feed. Observe all Federal, State and Local regulations when storing or disposing of this substance. Shelf Life: 24 Months Emergency Overview: Mergal BIT20 is a clear liquid with a slight odor. Corrosive liquid. May cause irreversible damage to the eyes. May cause moderate skin and respiratory irritation. This material is moderately toxic to fish. Avoid contamination of streams and sewers. Mergal BIT 20 is packaged in: Packaging Shipping Container Net Weight Pail 45 lbs/20.5 kg Drums 100 lbs/45.4 kg Drums 441 lbs/200.5 kg DOT Shipping Name UN3266, Corrosive liquid, inorganic, basic, n.o.s. (Sodium hydroxide) 8 PG lll, ERG# 154 Labels Required Corrosive IATA Shipping Name UN3266, Corrosive liquid, inorganic, basic, n.o.s. (Sodium hydroxide) 8 PG lll, ERG# 8L Labels Required Corrosive IMDG Shipping Name UN3266, Corrosive liquid, inorganic, basic, n.o.s. (Sodium hydroxide) 8 PG lll, EMS# F-A, S-B Labels Required Corrosive
MERGAL K 14
Mergal K 14 Mergal K 14 by Troy Corporation is a fast acting, water-soluble liquid bactericide and fungicide. It is a formulated isothiazolinone (CMIT/MIT) in-can preservative. Provides control of bacteria, yeast and fungi. Mergal K 14 is used in waterborne paints, and other coating products where water is a component. The product is suited for systems with a pH of 3 up to approximately 8 or 9. Mergal K 14 by Troy Corporation is s stabilized CMIT/MIT-based bactericide. Acts as a water-soluble, liquid preservative for control of bacteria, yeast, mold, and algae in adhesives, caulks and sealants. Mergal K 14 offers improved stability and speed of sanitation. MERGAL K14 is an effective, broad-spectrum liquid preservative designed to inhibit the growth of bacteria, yeast and fungi in aqueous systems. Mergal K14 is a water-soluble liquid preservative for control of bacteria, yeast, mold, and algae in adhesives, emulsions, dispersion paints and coatings, metalworking fluids, and building material. Intended for use in aqueous products with a range of pH 3-9. (EPA Registration Number 5383-104) Used In Recommended for waterborne adhesives, paints and coatings, emulsions and sealants. Typical Properties of Mergal K 14 Appearance Clear amber liquid pH value 4.0 Density 8.53 lbs/gal Specific Gravity 1.025 Mergal K 14 (sometimes isothiazolone) is a heterocyclic chemical compound related to isothiazole. Compared to many other simple heterocycles its discovery is fairly recent, with reports first appearing in the 1960s.[1] The compound itself has no applications, however its derivatives are widely used as biocides. Synthesis of Mergal K 14 Various synthetic routes have been reported.[2] Mergal K 14s are typically prepared on an industrial scale by the ring-closure of 3-sulfanylpropanamide derivatives. These in turn are produced from acrylic acid via the 3-mercaptopropionic acid. Ring-closure involves conversion of the thiol group into a reactive species which undergoes nucleophilic attack by the nitrogen center. This typically involves chlorination,[1] or oxidation of the 3-sulfanylpropanamide to the corresponding disulfide species. These reaction conditions also oxidize the intermediate isothiazolidine ring to give the desire product. Applications of Mergal K 14 Mergal K 14s are antimicrobials used to control bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, wood preservation and antifouling agents. They are frequently used in personal care products such as shampoos and other hair care products, as well as certain paint formulations. Often, combinations of MIT and CMIT (known as Kathon CG) or MIT and BIT are used. Biological implications Together with their wanted function, controlling or killing microorganisms, Mergal K 14s also have undesirable effects: They have a high aquatic toxicity and some derivatives can cause hypersensitivity by direct contact or via the air. Mergal K 14 is an Isothiazolone biocide having a 3:1 ratio of CMIT and MIT, widely used for its broad-spectrum action against microbes, algae, and fungi. Mergal K 14 is one of the active ingredients of humidifier disinfectants and a commonly used preservative in industrial products such as cosmetics, paints, adhesives and detergents. Mergal K 14 is a 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product Exocide. It has a role as an antimicrobial agent, a xenobiotic and an environmental contaminant. Mergal K 14 is a member of 1,2-thiazoles and an organochlorine compound. Mergal K 14 derives from a Isothiazolone. Mergal K 14 (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. Mergal K 14 is found within many commercially available cosmetics, lotions, and makeup removers. Mergal K 14 is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. The American Contact Dermatitis Society named Mergal K 14 the Contact Allergen of the Year for 2013. Sensitivity to Mergal K 14 may be identified with a clinical patch test. Mergal K 14 is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. Mergal K 14 is a powerful biocide and preservative and is the minor active ingredient in the commercial product Exocide. Mergal K 14 has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent. Features & Benefits of Mergal K 14 Broad-spectrum of activity Low level of metal salt Protection against bacteria and fungi Wide range of pH stability up to 8.5 Effective at a low level of use 0.05 - 0.15% No color or odor imparted into end products Excellent compatibility with surfactants Safe at recommended use levels Rapidly biodegradable Active Ingredient in this product is listed by EPA in the Safer Chemical Ingredients List (SCIL) Applications of Mergal K 14 Cleaners and polishes, such as all-purpose cleaners, cleaning and industrial use wipes, floor and furniture polishes/waxes, automotive washes, polishes and waxes Laundry products, such as liquid laundry detergents, fabric softeners and pre-spotters Liquid detergents, such as dish wash detergents and general liquid cleaning solution Other applications, such as moist towelettes, air fresheners, moist sponges, gel air fresheners Raw materials and surfactants preservation Chloromethyl-methylMergal K 14 (Mergal K 14) is a broad spectrum biocide which has been used successfully for microbial control and preventing biofouling in industrial water treatment. ATAMAN CHEMICALS reports over the past 20 years on the efficacy of Mergal K 14 biocide versus Legionella bacteria and the protozoa associated with their growth. The studies included a wide range of conditions, including single organisms in cooling water and complex model systems with bacteria, biofilms, and protozoa. Overall, low levels of Mergal K 14 (1-10 ppm active) provided significant reduction in viable counts of various strains and species of Legionella bacteria in planktonic and biofilm studies and also against the amoebae and ciliated protozoa associated with their growth. Mergal K 14 BIOCIDES IN WATER TREATMENT Mergal K 14 biocides are widely used for microbial control in industrial water treatment. The most frequently used product is a 3:1 ratio of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl- 4-isothiazolin-3-one (MIT) at a final concentration of 1.5% total active ingredient. Mergal K 14 has broad spectrum efficacy versus bacteria, algae, and fungi. Exocide product is a blend of Isothiazolinones and is composed of 5-chloro-2-methyl-4-thiazoline-3-ketone (CMIT) and 2-methyl-4-thiazoline-3-ketone (MIT). The bactericidal effect of Isothiazolinones is carried out through breaking the bond between the bacteria and algae protein. The product can be used in many industrial applications to inhibit microbes’ growth, and it has inhibition and biocidal effects on ordinary bacteria, fungi and algae. Isothiazolinones (also Mergal K 14) is a blended biocide with Mergal K 14 and Isothiazolinone which carry out the bactericidal effect through breaking the bond of bacteria and algae cell protein. When isothiazolinones contact with microbes, it can quickly break cell protein bond and inhibit their growth, and then lead to the apoptosis of these microbes. Isothiazolinone products can be effective in controlling both the planktonic and surface growth at very low concentrations and have been produced specifically for oilfield water treatment and paper mill applications. Mergal K 14 has strong biocidal effects on ordinary bacteria, algae and fungi which has many advantages such as no residue, good compatibleness, high stabilization, good degradation, safety and low cost in operation. Isothiazolinone products can mix with other chlorine biocides and most cation, anion, and non-ionic surfactants. It can be an excellent eco-friendly sludge remover when used at high dosage. Mergal K 14 and Isothiazolinone are fungicidal with properties of high efficiency, broad spectrum, non-oxidative and low toxicity. Mergal K 14 is the most suitable biocide in industrial circulating cool water systems and in wastewater treatment for oilfield, papermaking, pesticide and other industries. Bichain is one of reliable isothiazolinones manufacturers and suppliers of Mergal K 14, CMIT and MIT for oilfield water treatment. We supply high quality isothiazolinone products with CAS 55965-84-9. Area of use Mergal K 14 is often not stable under certain conditions such as high temperatures or high pH values. Normally it is stabilised with Mg, Cu or Na salts. However, some applications are sensitive to salts or electrolyte. In this case Exocide 1012 AG is an excellent alternative. This broadband biocide is used to preserve water-based and water-dilutable chemical/technical products, and can be used as an in-can preservative in technical applications such as paints, adhesives, and household and industrial cleaners. Mergal K 14 is especially suitable for preserving fuels such as diesel, or for use in secondary oil production. This Exocide is also suitable as a slimicide, protective media for liquids in cooling and production systems, and as a protective medium for fluids used in metalworking. This biocide formulation has a broad antimicrobial spectrum of activity against bacteria, fungi and yeasts and can be used in many cases where other products fail. Product properties of Mergal K 14 Exocide 1012 AG is free of formaldehyde, formaldehyde releasers, phenols and heavy metals, and exhibits excellent chemical stability. It is not volatile, exhibits outstanding long-term effectiveness, and is one of the best examined broadband biocides. CMIT and CMI Mergal K 14 (MIT or MI) and Isothiazolinone (CMIT or CMI) are two preservatives from the family of substances called isothiazolinones, used in some cosmetic products and other household products. MIT can be used alone to help preserve the product or it may be used together with CMIT as a blend. Preservatives are an essential element in cosmetic products, protecting products, and so the consumer, against contamination by microorganisms during storage and continued use. MIT and CMIT are two of the very limited number of ‘broad spectrum’ preservatives, which means they are effective against a variety of bacteria, yeasts and moulds, across a wide range of product types. MIT and CMIT have been positively approved for use as preservatives for many years under the strict European cosmetics legislation. The primary purpose of these laws is to protect human safety. One of the ways it does this is by banning certain ingredients and controlling others by limiting their concentration or restricting them to particular product types. Preservatives may only be used if they are specifically listed in the legislation. MIT Mergal K 14 can be used on its own to help preserve cosmetic products. Following discussions with dermatologists, who reported an increase in cases of allergy to Mergal K 14 in their clinics, the European cosmetics industry assessed the available information regarding the risk of allergic reactions to Mergal K 14, and in December 2013, the European Personal Care Association, Cosmetics Europe, issued a Recommendation for companies to discontinue the use of MIT in leave-on skincare products. The European Commission’s independent expert scientific panel (the Scientific Committee on Consumer Safety, SCCS), which advises on safety matters, reviewed the use of MIT in cosmetic products. In 2013, the SCCS also recommended that MIT be removed from leave-on cosmetic products and that the amount of Mergal K 14 used in rinse-off cosmetic products should be reduced. As a result, the European Commission changed the cosmetic law to ban the use of MIT in leave-on cosmetic products. Since 12 February 2017, it is no longer permitted to make these products available to consumers. In addition, the maximum amount of MIT present in rinse-off products has been reduced and since 27 April 2018, all products made available to consumers must comply with the new limit. If consumers have been diagnosed as allergic to Mergal K 14 it is important to check the ingredient list of rinse-off cosmetic products. The name ‘Mergal K 14’ will always be listed as ‘Mergal K 14’ regardless of where in Europe a product is purchased. MIT/CMIT Blend Mergal K 14 may also be used in a blend with CMIT. If the Mergal K 14 and CMIT blend is used to preserve a cosmetic product, then the names Mergal K 14 and Mergal K 14 will both be present in the ingredients list, which every cosmetic product must have either on its carton, pack or label, card etc. at point of sale. In its review of the MIT/CMIT blend, the SCCS has stated that the MIT/CMIT blend should only be allowed to be used in rinse-off cosmetic products. As a result, the European cosmetic law was changed to restrict the use of this blend to rinse-off products only from April 2016. CMIT: Mergal K 14, also referred to as CMIT, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. These compounds have an active sulphur moiety that is able to oxidize thiol-containing residues, thereby effectively killing most aerobic and anaerobic bacteria. Mergal K 14 is effective against gram-positive and gram-negative bacteria, yeast, and fungi. Mergal K 14 is found in many water-based personal care products and cosmetics. Mergal K 14 was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Mergal K 14 is known by the registered tradename Kathon CG when used in combination with Mergal K 14. Mergal K 14 may be used in combination with other preservatives including ethylparaben, benzalkonium chloride, and bronopol. In pure form or in high concentrations, Mergal K 14 is a skin and membrane irritant and causes chemical burns. In the United States, maximum authorized concentrations are 15 ppm in rinse-offs (of a mixture in the ratio 3:1 of 5-chloro-2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3 (2H)-one). In Canada, Mergal K 14 may only be used in rinse-off products in combination with Mergal K 14, the total concentration of the combination may not exceed 15 ppm. MIT: Mergal K 14, MIT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications. It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and has been reported as a contact sensitizing agent by the European Commission’s Scientific Committee on Consumer Safety. Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined. Applications of Mergal K 14 Mergal K 14 and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions. Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloroMergal K 14 or CMIT) and 2-methyl-4-isothiazolin-3-one (Mergal K 14 or MIT), which are the active ingredients in a 3:1 mixture (CMIT:MIT) sold commercially as Exocide. Exocide is supplied to manufacturers as a concentrated stock solution containing from 1.5-15% of Mergal K 14. For applications the recommended use level is from 6 ppm to 75 ppm active Mergal K 14s. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production. Mergal K 14 also has been used to control slime in the manufacture of paper products that contact food. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food. Other isothiazolinones One Mergal K 14, Sea-Nine 211 (4,5-dichloro-2-n-octyl-4-isothiazolino-3-one, DCOI), has quickly replaced tributyltin as the antifouling agent of choice in ship hull paint. A recent study reported the presence of DCOI in both port water and sediment samples in Osaka, Japan, especially in weakly circulating mooring areas. Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species. Isothiazolinones also are extremely toxic to fish. In industrial use, the greatest occupational inhalation exposure occurs during open pouring. Non-occupational exposure to Mergal K 14 by the general population also occurs, albeit at much lower concentrations. These compounds are present in a very large number of commonly used cosmetics. Human health Mergal K 14 is allergenic and cytotoxic, and this has led to some concern over its use. A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT. Rising reports of consumer impact led to new research, including a report released in 2014 by the European Commission Scientific Committee on Consumer Safety which reported: "The dramatic rise in the rates of reported cases of contact allergy to MI, as detected by diagnostic patch tests, is unprecedented in Europe; there have been repeated warnings about the rise (Gonçalo M, Goossens A. 2013). The increase is primarily caused by increasing consumer exposure to MI from cosmetic products; exposures to MI in household products, paints and in the occupational setting also need to be considered. The delay in re-evaluation of the safety of MI in cosmetic products is of concern to the SCCS; it has adversely affected consumer safety." "It is unknown what proportion of the general population is now sensitized to MI and has not been confirmed as sensitized." In 2014, the European Commission Scientific Committee on Consumer Safety further issued a voluntary ban on "the mixture of Mergal K 14 (MCI/MI) from leave-on products such as body creams. The measure is aimed at reducing the risk from and the incidence of skin allergies. The preservative can still be used in rinse-off products such as shampoos and shower gels at a maximum concentration of 0.0015 % of a mixture in the ratio 3:1 of MCI/MI. The measure will apply for products placed on the market after 16 July 2015." Shortly thereafter, Canada moved to adopt similar measures in its Cosmetic Ingredients Hotlist. Additionally, new research into cross reactivity of MI-sensitized patients to variants benzisothiazolinone and octylisothiazolinone have found that reactions may occur if present in sufficient amounts. Allergic contact dermatitis Mergal K 14 is used commonly in products in conjunction with Mergal K 14, a mixture sold under the registered trade name Kathon CG. A common indication of sensitivity to Kathon CG is allergic contact dermatitis. Sensitization to this family of preservatives was observed as early as the late 1980s. Due to increased use of isothiazolinone-based preservatives in recent years, an increase in reported incidences of contact allergy to this product has been reported. In 2013 the substance was declared the 2013 Contact Allergen of the Year by the American Contact Dermatitis Society. In 2016 the Dermatitis Academy launched a call to action for patients to report their isothiazolinone allergy to the FDA. On December 13, 2013 the trade group, Cosmetics Europe,following discussions with the European Society of Contact Dermatitis (ESCD),recommended to its members "that the use of Mergal K 14 (MIT) in leave-on skin products including cosmetic wet wipes is discontinued. This action is recommended in the interests of consumer safety in relation to adverse skin reactions. It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible." On March 27, 2014, the European Commission’s Scientific Committee on Consumer Safety issued an opinion on the safety of Mergal K 14. This report only considered the issue of contact sensitization. The committee concluded: “Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer. "For leave-on cosmetic products (including ‘wet wipes’), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated. "For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) Mergal K 14 is considered safe for the consumer from the view of induction of contact allergy. However, no information is available on elicitation
MERGAL K6N
MERGAL K6N Hızlı etkili, geniş spektrumlu kutu içi koruyucu Açıklama Mergal K6N, sulu sistemlerde bakteri, maya ve mantarların büyümesini engellemek için tasarlanmış etkili, geniş spektrumlu bir sıvı koruyucudur. Uygulama ve Kullanım Mergal K6N, su bazlı sistemlere kolayca dahil edilen sıvı bir üründür. Mergal K6N, su bazlı boyalar ve sıvalar, yapıştırıcılar, pigment bulamaçları, nişasta solüsyonları ve sızdırmazlık malzemeleri için önerilir. Mergal K6N ayrıca mürekkeplerde, fıskiye solüsyonlarında, polimer emülsiyonlarında, reoloji değiştiricilerde ve mum emülsiyonlarında da kullanışlıdır. Mergal K6N ayrıca deterjanları, ev temizlik malzemelerini ve benzeri ürünleri korumak için de kullanılabilir. Ürün hızlı hareket ediyor. Mergal K6N şu sistemlere uygulanabilir: pH 3 ila 9, ve Soğutma aşamasında 60 ° C'ye kadar olan sıcaklıklarda işlenmiş malzemelere dahil edilebilir. Ürün Özellikleri Geniş Spektrum koruması Headspace koruması Hızlı etkili İyi sterilizasyon özellikleri Düşük kullanım seviyesi Uygun maliyetli Fiziksel özellikler Aşağıdakiler, Mergal K6N'nin tipik özellikleridir; ürün özellikleri olarak kabul edilmemelidir. Görünüş: şeffaf, neredeyse renksiz sıvı Özgül Ağırlık, 25 ° C: yakl. 1.05 pH (olduğu gibi) tipik olarak 3 ila 6 Çözünürlük: Su ile her oranda karışabilir Antimikrobiyal etkinlik Mergal K6N, çok çeşitli mikroorganizmalara karşı geniş bir etkinlik yelpazesine sahiptir. Mergal K6N tarafından kontrol edilen organizma örnekleri: Bakteriler MIC Mantarlar MIC Bacillus subtilis 0,05 Aspergillus niger 0,02 Enterobacter aerogenes 0,05 Chaetomium globosum 0,02 Escherichia coli 0,02 Penicillium funiculosum 0,02 Proteus vulgaris 0.05 Ulocladium consortiale 0.01 Pseudomonas aeruginosa 0.02 Pseudomonas flurescence 0.01 Maya MIC Yosun MIC Candida albicans 0,02 Chlorella fusca 0,002 Saccharomyces cerevisiae 0.01 Anabaena cylindrica 0.001 İşlev / Etkinlik Mergal K6N tipik olarak boya uygulamalarında nihai ürünün ağırlıkça% 0,1 ila% 0,3'ü oranında kullanılır. Herhangi bir sistemi korumak için gereken seviye, çeşitli faktörlere bağlıdır: başlangıçtaki mikrobiyolojik kontaminasyon seviyesi, sistemin bileşenleri, tekrar mikrobiyolojik müdahalelere maruz kalma olasılığı, artık indirgeyici ve oksitleyici ajanlar ve sistemin sıcaklığı ve pH'ı . Önerilen kullanım seviyeleri saha denemeleri ile doğrulanmalı ve son kullanım ürününün yüzdesi olarak rapor edilmelidir. % Ağırlık / Ağırlık Boya: 0.10 - 0.30 Su bazlı ahşap kaplamalar: 0,05 - 0,20 Yapıştırıcılar, macunlar ve sızdırmazlık malzemeleri: 0,05 - 0,20 Polimer Emülsiyonu: 0.10 - 0.20 Baskı Mürekkepleri: 0.10 - 0.30 Formülasyonla İlgili Hususlar Mergal K6N, su bazlı sistemlere kolayca dahil edilen sıvı bir üründür. En iyi sonuçlar için Mergal K6N, üretim sürecine mümkün olduğunca erken eklenmelidir. Üretim sırasında yüksek sıcaklıklar veya yüksek alkali pH değerleri bekleniyorsa, ürün bu şartlar kontrol edildikten sonra veya işlemin başında 1/3 Mergal K6N ve sonunda 2/3 ilave edilerek ilave edilmelidir. Mergal K6N, en bilinen sistemlerle uyumludur. Güçlü indirgeme ajanlarının varlığı, aktiflerin bozunmasına neden olabilir. Protein bazlı yapıştırıcılar gibi çapraz bağlanabilen malzemelerle uyumsuzluklar meydana gelebilir. Çeşitli uygulama olanakları ve farklı işleme yöntemleri nedeniyle, yeni ürünlerin geliştirilmesinde uyumluluğun kontrol edilmesi önerilir. Lütfen yardım için ATAMAN CHEMICALS temsilcinizle iletişime geçin. Mergal K6N ile çalışırken koruyucu için olağan önlemler alınmalıdır. Konsantre ile temastan kaçınılmalıdır. Mergal K6N ile çalışırken koruyucu giysi ve koruyucu gözlük takılmalıdır. Cilde sıçraması durumunda derhal bol su ve sabunla yıkayın. Göze sıçraması halinde bol su ile yıkayınız ve bir hekime başvurunuz. Kirlenmiş giysiler derhal çıkarılmalıdır. Raf Ömrü: Üretim tarihinden itibaren 24 ay. Kabı sıkıca kapalı tutun. Yalnızca yeterli havalandırmayla kullanın. Daima doğrudan güneş ışığından ve ısı kaynaklarından koruyun. 40 ° C'den yüksek sıcaklıklardan kaçının. 5 - 25 ° C arasında saklandığında en uzun raf ömrü elde edilir. Donmamaya dikkat edin. Uyumsuz maddelerden uzakta, kuru ve havalandırılmış bir yerde saklayın. Yiyecek veya yem yakınında saklamayın.
MERQUAT 280 POLYMER
Merquat 280 Polymer has excellent stability in extreme pH applications making it ideally suited for use in high pH products as well as shampoos.
More to that, Merquat 280 Polymer is also recommended for ethnic hair care, hair color, shampoos, and depilatories.



APPLICATIONS


Merquat 280 Polymer is an aqueous, cationic copolymer that demonstrates ampholytic characteristics and is non-preserved.
Further to that, Merquat 280 Polymer has excellent stability in extreme pH applications making it ideally suited for use in high pH products as well as shampoos.

Merquat 280 Polymer is also recommended for ethnic hair care, hair color, and depilatories.
Additionally, Merquat 280 Polymer is a dry copolymer that demonstrates ampholytic characteristics.

Merquat 280 Polymer has excellent stability in extreme pH applications making it ideally suited for use in products for dry or chemically treated hair.
Furthermore, Merquat 280 Polymer is also recommended for ethnic hair care as well as skin care applications.

Merquat 280 Polymer acts as a conditioning agent.
Moreover, Merquat 280 Polymer is an aqueous, cationic copolymer with ampholytic characteristics.
Merquat 280 Polymer possesses excellent stability in extreme pH applications.

Merquat 280 Polymer enables the reduction of ammonia and hair dye levels.
Besides, Merquat 280 Polymer helps to improve the saturation of hair colors, improves the wet combability of hair dyes & provides a smooth, soft feel to hair.

Merquat 280 Polymer improves wet & dry combing in shampoo systems.
In addition, Merquat 280 Polymer provides stable, rich and dense foam.
Merquat 280 Polymer is used in formulating body wash, conditioners, ethnic hair care, hair coloring, depilatories, hand soaps and shampoos.

Merquat 280 Polymer functions as conditioner.
Further, Merquat 280 Polymer can be used as sensory modifier.


Features / Benefits of Merquat 280 Polymer:

Enables the reduction of ammonia and hair dye levels.
Helps to improve the saturation of hair colors.
Improves the wet combability of hair dyes and provides a smooth, soft feel to hair.
Improves wet and dry combing in shampoo systems.
Provides stable, rich and dense foam.
Provides superior conditioning properties in high pH systems.


Applications of Merquat 280 Polymer:

Body Wash
Conditioners
Hair Coloring
Hand Soap
Shampoo


Merquat 280 Polymer is an aqueous copolymer that demonstrates ampholytic characteristics.
More to that, Merquat 280 Polymer has excellent stability in extreme pH applications making it ideally suited for use in products for dry or chemically treated hair.
Merquat 280 Polymer is also recommended for ethnic hair care as well as skin care applications.



DESCRIPTION


Merquat 280 Polymer is an aqueous, cationic copolymer that demonstrates ampholytic characteristics.
Further to that, Merquat 280 Polymer has excellent stability in extreme pH applications making it ideally suited for use in high pH products as well as shampoos.

Merquat 280 Polymer is also recommended for ethnic hair care, hair color, shampoos, and depilatories.
Additionally, Merquat 280 Polymer has excellent conditioning in extreme pH applications.

Merquat 280 Polymer is an aqueous, cationic copolymer that demonstrates ampholytic characteristics.
Furthermore, Merquat 280 Polymer has excellent stability in extreme pH applications making it ideally suited for use in high pH products as well as shampoos.
Merquat 280 Polymer is also recommended for ethnic hair care, hair color, shampoos, and depilatories.

Merquat 280 Polymer is an aqueous, cationic copolymer that demonstrates ampholytic characteristics and is non-preserved.
Moreover, Merquat 280 Polymer is a copolymer demonstrating ampholytic characteristics with excellent stability in extreme pH applications



PROPERTIES


Molecular Weight: 233.73
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 5
Exact Mass: 233.1182566
Monoisotopic Mass: 233.1182566
Topological Polar Surface Area: 37.3 Ų
Heavy Atom Count: 15
Formal Charge: 0
Complexity: 147
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes



FIRST AID


General advice:

No hazards which require special first aid measures.


If inhaled:

If breathed in, move person into fresh air.
If unconscious, place in recovery position and seek medical advice.
If symptoms persist, call a physician.


In case of skin contact:

First aid is not normally required.
However, it is recommended that exposed areas be cleaned by washing with soap and water.


In case of eye contact:

Remove contact lenses.
Protect unharmed eye.


If swallowed:

Do not give milk or alcoholic beverages.
Never give anything by mouth to an unconscious person.
If symptoms persist, call a physician.


Most important symptoms and effects, both acute and delayed:

No symptoms known or expected.


Notes to physician:

No hazards which require special first aid measures.



HANDLING AND STORAGE


Advice on safe handling:

Smoking, eating and drinking should be prohibited in the application area.


Conditions for safe storage:

Containers which are opened must be carefully resealed and kept upright to prevent leakage.


Materials to avoid:

No materials to be especially mentioned



SYNONYMS


conditioneze 22 polymer
merquat 280 polymer
merquat 280SD polymer
merquat 281 polymer
merquat 295 polymer
2-propenaminium
N,N-dimethyl-N-(2-propenyl)-
chloride
polymer with 2-propenoic acid
Acrylic acid-dimethyldiallylammonium chloride copolymer
2-Propenoic acid
polymer with N,N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride (9CI)
2-Propen-1-aminium
N,N-dimethyl-N-2-propen-1-yl-
chloride (1:1)
polymer with 2-propenoic acid
2-Propen-1-aminium
N,N-dimethyl-N-2-propenyl-, chloride
polymer with 2-propenoic acid (9CI)
Floc Aid 34
Diallyldimethylammonium chloride-acrylic acid copolymer
Merquat 280SD
Conditioneze 22
Acrylic acid-diallyldimethylammonium chloride copolymer
N,N-Diallyl-N,N-dimethylammonium chloride-acrylic acid copolymer
Acrylic acid-diallyldimethylammonium chloride polymer
Dimethyldiallylammonium chloride-acrylic acid copolymer
Merquat 295
Merquat 281
Merquat 280
Merquat 280 Dry
OF 280
Acrylic acid-DADMAC copolymer
Merquat 295 Dry;
MESAMOLL® / MESAMOLL® II

Mesamoll® and Mesamoll® II are high-performance plasticizers used in various polymer applications for their excellent compatibility and versatility.
Mesamoll® and Mesamoll® II are characterized by their ability to enhance the flexibility and durability of polymer products.
The chemical formulas for Mesamoll® and Mesamoll® II are proprietary, and they are commonly used in various industrial applications due to their superior properties.

CAS Number: 91-20-3 (Mesamoll®), 1241-94-7 (Mesamoll® II)
EC Number: 202-049-5 (Mesamoll®), 214-999-2 (Mesamoll® II)

Synonyms: Plasticizer, Mesamoll® I, Mesamoll® II, Polymer plasticizer, Mesamoll Polymer Plasticizer, Plasticizing Agent, Polymer Additive Mesamoll, Plasticizer Additive Mesamoll, PU Plasticizer Mesamoll, Flexible Additive Mesamoll



APPLICATIONS


Mesamoll® and Mesamoll® II are widely used in the formulation of flexible PVC products, providing excellent flexibility and durability.
Mesamoll® and Mesamoll® II are essential in the manufacture of high-performance polyurethane foams, enhancing their flexibility.
Mesamoll® and Mesamoll® II are utilized in the production of elastomers, improving their flexibility and longevity.

Mesamoll® and Mesamoll® II are preferred plasticizers for flexible and rigid foams due to their efficiency in enhancing flexibility.
Mesamoll® and Mesamoll® II are used in automotive applications for their excellent flexibility and durability under various conditions.
Mesamoll® and Mesamoll® II are found in the production of sealants and caulks, contributing to their flexibility and performance.

Mesamoll® and Mesamoll® II are used in water-based polymer systems for their compatibility and efficiency in enhancing flexibility.
Mesamoll® and Mesamoll® II are key components in solvent-based polymer formulations, providing improved flexibility.
Mesamoll® and Mesamoll® II are used in the textile industry to improve the flexibility and performance of coatings on fabrics.

Mesamoll® and Mesamoll® II are employed in the production of rubber materials for their plasticizing properties.
Mesamoll® and Mesamoll® II are used in the manufacturing of synthetic fibers, enhancing their flexibility and resilience.
Mesamoll® and Mesamoll® II are used in the construction industry for high-performance coatings and sealants.

Mesamoll® and Mesamoll® II are used in the creation of high-performance adhesives, providing improved flexibility and durability.
Mesamoll® and Mesamoll® II are key components in the production of plastics, enhancing their flexibility and mechanical properties.
Mesamoll® and Mesamoll® II are utilized in the formulation of industrial coatings, ensuring improved flexibility and performance.

Mesamoll® and Mesamoll® II are applied in the creation of specialty coatings for various industrial applications, ensuring enhanced flexibility and performance.
Mesamoll® and Mesamoll® II are used in the production of coatings for metal surfaces, providing improved flexibility and durability.
Mesamoll® and Mesamoll® II are essential in the creation of high-quality printing inks, enhancing flexibility and performance during printing.

Mesamoll® and Mesamoll® II are used in the production of rubber products, ensuring consistent flexibility and performance.
Mesamoll® and Mesamoll® II are employed in the automotive industry, used in high-performance coatings and adhesives for improved flexibility.
Mesamoll® and Mesamoll® II are utilized in the production of wood coatings, enhancing their flexibility and durability.

Mesamoll® and Mesamoll® II are found in the manufacture of specialty coatings for industrial machinery, providing improved flexibility and performance.
Mesamoll® and Mesamoll® II are utilized in the formulation of adhesives and sealants, ensuring enhanced flexibility and performance.
Mesamoll® and Mesamoll® II are key ingredients in the production of polyurethane elastomers, enhancing their flexibility and longevity.

Mesamoll® and Mesamoll® II are employed in the textile industry to improve the performance and flexibility of coatings on fabrics.
Mesamoll® and Mesamoll® II are used in the rubber industry for their plasticizing properties, improving flexibility and performance.
Mesamoll® and Mesamoll® II are essential in the production of high-performance industrial coatings, providing improved flexibility and durability.

Mesamoll® and Mesamoll® II are vital components in water-based and solvent-based polymer systems, ensuring enhanced flexibility and performance.
Mesamoll® and Mesamoll® II are applied in the creation of high-performance industrial products, providing improved flexibility and durability.
Mesamoll® and Mesamoll® II are used in the formulation of household and industrial coatings, enhancing their flexibility and performance.

Mesamoll® and Mesamoll® II are utilized in the production of specialty coatings for electronic devices, providing improved flexibility.
Mesamoll® and Mesamoll® II are found in the creation of specialty inks for various applications, enhancing flexibility and performance.
Mesamoll® and Mesamoll® II are used in the production of ceramic and glass coatings, improving their flexibility and application properties.

Mesamoll® and Mesamoll® II are applied in the creation of coatings for plastic surfaces, ensuring improved flexibility and performance.
Mesamoll® and Mesamoll® II are utilized in the formulation of coatings for wood surfaces, providing enhanced flexibility and durability.
Mesamoll® and Mesamoll® II are essential in the production of high-performance adhesives, ensuring improved flexibility and application properties.

Mesamoll® and Mesamoll® II are used in the formulation of coatings for automotive applications, providing improved flexibility and performance.
Mesamoll® and Mesamoll® II are utilized in the production of specialty adhesives and sealants, ensuring enhanced flexibility and durability.
Mesamoll® and Mesamoll® II are found in the manufacture of coatings for industrial machinery, providing improved flexibility and performance.

Mesamoll® and Mesamoll® II are employed in the creation of specialty coatings for various substrates, ensuring improved flexibility and performance.
Mesamoll® and Mesamoll® II are used in the formulation of high-performance coatings for various applications, providing enhanced flexibility and performance.
Mesamoll® and Mesamoll® II are key components in the production of specialty inks for flexographic and gravure printing, ensuring improved flexibility and performance.

Mesamoll® and Mesamoll® II are used in the creation of specialty inks for digital printing, providing enhanced flexibility and application properties.
Mesamoll® and Mesamoll® II are essential in the production of high-performance industrial products, ensuring improved flexibility and performance.
Mesamoll® and Mesamoll® II are utilized in the manufacture of environmentally friendly industrial products, providing enhanced flexibility and durability.

Mesamoll® and Mesamoll® II are used in the creation of water-based and solvent-based products, ensuring improved flexibility and performance.
Mesamoll® and Mesamoll® II are critical ingredients in the formulation of specialty coatings for metal and plastic surfaces, providing enhanced flexibility and application properties.



DESCRIPTION


Mesamoll® and Mesamoll® II are high-performance plasticizers used in various polymer applications for their excellent compatibility and versatility.
Mesamoll® and Mesamoll® II are characterized by their ability to enhance the flexibility and durability of polymer products.

Mesamoll® and Mesamoll® II are versatile chemical compounds used in various polymer applications.
Mesamoll® and Mesamoll® II are known for their strong plasticizing properties, which improve the flexibility and performance of polymer products.
Mesamoll® and Mesamoll® II provide excellent compatibility with a wide range of polymers, making them ideal for industrial coatings and adhesives.

Mesamoll® and Mesamoll® II are compatible with a wide range of polymer systems, enhancing their versatility in different formulations.
Mesamoll® and Mesamoll® II are widely used in the coatings, adhesives, elastomers, and sealants industries, among others.
Mesamoll® and Mesamoll® II's non-toxic nature makes them safe for use in various industrial and consumer products.

Mesamoll® and Mesamoll® II offer excellent flexibility, making them suitable for applications requiring enhanced flexibility and durability.
Mesamoll® and Mesamoll® II are known for their ease of dispersion, ensuring uniform plasticizing in various systems.
Mesamoll® and Mesamoll® II are essential in the creation of durable and high-performance polymer products.

Mesamoll® and Mesamoll® II's strong plasticizing properties make them preferred choices in the creation of high-quality industrial coatings.
Mesamoll® and Mesamoll® II are important precursors in the production of high-performance adhesives and sealants, providing improved flexibility.
Mesamoll® and Mesamoll® II are widely used in the manufacture of durable and resilient polymer products, ensuring enhanced flexibility and performance.



PROPERTIES


Chemical Formula: Proprietary
Common Name: Mesamoll® / Mesamoll® II
Molecular Structure: Proprietary
Appearance: Clear liquid
Density: 1.05 g/cm³
Viscosity: Low
Solubility: Miscible with most organic solvents
Reactivity: Low
Chemical Stability: Excellent
Compatibility: Wide range of polymer systems
Flexibility: Excellent
Dispersion: Easy



FIRST AID


Inhalation:
If Mesamoll® or Mesamoll® II is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of vapors.
Do not eat, drink, or smoke while handling Mesamoll® or Mesamoll® II.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Absorb spills with inert materials (e.g., sand, vermiculite) and collect for disposal.

Storage:
Store Mesamoll® and Mesamoll® II in a cool, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating aerosols or mists.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where vapors may be present.


Storage:

Temperature:
Store Mesamoll® and Mesamoll® II at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store Mesamoll® and Mesamoll® II away from incompatible materials, including strong acids, bases, oxidizing agents, and reducing agents.

Handling Equipment:
Use dedicated equipment for handling Mesamoll® and Mesamoll® II to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.
METANITROBENZENE SULFONIC ACID, SODIUM SALT
Synonyms: Oligo tartaric acid;Tartaric acid, oligomer CAS: 31054-64-5
Metatartaric acid
BUTYL METHACRYLATE, N° CAS : 97-88-1, Nom INCI : BUTYL METHACRYLATE, Nom chimique : Butyl methacrylate, N° EINECS/ELINCS : 202-615-1, Agent filmogène : Produit un film continu sur la peau, les cheveux ou les ongles. Agent masquant : Réduit ou inhibe l'odeur ou le goût de base du produit. Agent de contrôle de la viscosité : Augmente ou diminue la viscosité des cosmétiques. Noms français : 2-METHYL-2-PROPENOIC ACID, BUTYL ESTER; 2-PROPENOIC ACID, 2-METHYL-, BUTYL ESTER; BUTYL 2-METHYLACRYLATE;METHYL-2 PROPENOATE DE BUTYLE; METHYL-2 PROPENOATE DE BUTYLE NORMAL; Méthacrylate de butyle; Méthacrylate de butyle normal; N-BUTYL 2-METHYLPROPENOATE;PROPENOIC ACID, 2-METHYL-, BUTYL ESTER. Noms anglais : Butyl methacrylate; METHACRYLIC ACID, BUTYL ESTER; N-BUTYL METHACRYLATE; NORMAL-BUTYL METHACRYLATE. Commentaires: Ce produit peut contenir un inhibiteur tel que l'éther monométhylique de l'hydroquinone.Utilisation: Fabrication de polymères, fabrication de résines. 2-Methyl-butylacrylaat; 2-Methyl-butylacrylat; 2-Methyl-butylacrylate; 2-Methylacrylic acid, butyl ester; 2-Propenoic acid, 2-methyl-, butyl ester; Butil metacrilato; Butyl 2-methacrylate; Butyl 2-methyl-2-propenoate;bütil metakrilat, butil metakrilat, bütil metakrilad, bütilmetakrilat; Butyl methacrylate; Butyl methacrylate monomer; Butylester kyseliny methakrylove; Butylmethacrylaat; Methacrylate de butyle; Methacrylic acid, butyl ester; Methacrylsaeurebutylester; N-Butyl methacrylate; n-BUTYL METHACRYLATE, STABILIZED butil-metakrilát (hu) butilmetakrilatas (lt) butyl-metakrylát (sk) butyl-methakrylát (cs) butylmetakrylat (sv) butylmethacrylat (da) ester butylowy kwasu metakrylowego (pl) metacrilat de n-butil (ro) metacrilato de butilo (es) metacrilato de n-butilo (pt) metakrylan butylu (pl) méthacrylate de n-butyle (fr) n-butil-metakrilat (hr) n-butilmetacrilato (it) n-butilmetakrilat (sl) n-butilmetakrilāts (lv) n-Butyl-methacrylat (de) n-butylmetakrylat (no) n-butylmethacrylaat (nl) n-Butyylimetakrylaatti (fi) n-butüülmetakrülaat (et) n-бутил-метакрилат (bg) μεθακρυλικός n-βουτυλεστέρας (el) 2-Propenoic acid, 2-methyl-, butyl esterRD_CLP_ 97-88-1_Butylmethacrylate_V1_20180205 butyl 2-methylprop-2-enoate , , Butyl Methacrylate (stabilized with HQ) butyl-methacrylate- Butyllmethacrylate MABU n-Butylmetacrylat n-Butylmethacrylat s 2-Methyl butylacrylate 2-Methyl-2-propenoic acid butyl ester (ECL) 2-Methyl-2-propenoic acid, n-butylester 2-Methyl-butylacrylaat (Dutch) 2-Propenoic acid, 2-methyl, butyl ester (9CI) Butil metacrilato (Italian) Butyl Methacrylate (BMA) Butylester kyseliny methakrylove (Czech) Butylmethacrylaat (Dutch) Butylmethacrylat (German) metacrilato de butilo (Spanish) Methacrylate de butyle (French) Methacrylic acid, butyl ester (8CI) Methacrylsäure-butylester (German) n-Butyl 2-methyl-2-propenoate PROP-2-ENOATE, 2-METHYL-, BUTYL (PICCS) VISIOMER®n-BMA
Methacrylamide
MELAMINE; Cymel; 1,3,5-Triazine-2,4,6-triamine; cyanuramide; cyanuric triamide; triaminotriazine; 2,4,6-triamino-1,3,5-triazine; cyanurotriamide; Teoharn; Theoharn; Virset 656-4; cyanurotriamine; 2,4,6-triamino-s-triazine; s-triaminotriazine; 2,4,6-triamino sym-triazine; 1,3,5-triazine-2,4,6(1H,3H,5H)triimine; cas no: 108-78-1
Méthacrylate de butyle ( BUTYL METHACRYLATE)
METHACRYLIC ACID; MAA; 2-Methylenepropionic Acid; 2-Methacrylic acid; 2-Methyl-2-propenoic Acid; Acide methacrylique (French); Acido metacrilico (Spanish); alpha-Methylacrylic acid; Kyselina methakrylova cas no: 79-41-4
Methacrylıc acıd
cas no: 108-78-1 Cymel; 1,3,5-Triazine-2,4,6-triamine; cyanuramide; cyanuric triamide; triaminotriazine; 2,4,6-triamino-1,3,5-triazine; cyanurotriamide; Teoharn; Theoharn; Virset 656-4; cyanurotriamine; 2,4,6-triamino-s-triazine; s-triaminotriazine; 2,4,6-triamino sym-triazine; 1,3,5-triazine-2,4,6(1H,3H,5H)triimine;
METHACRYLIC ACID
DESCRIPTION:
Methacrylic acid, abbreviated MAA, is an organic compound with the formula CH2=C(CH3)COOH.
This colorless, viscous liquid is a carboxylic acid with an acrid unpleasant odor.
Methacrylic acid is soluble in warm water and miscible with most organic solvents.


CAS Number: 79-41-4
EC Number: 201-204-4
IUPAC Name: 2-methylprop-2-enoic acid
Molecular Formula: C4H6O2




Methacrylic acid is produced industrially on a large scale as a precursor to its esters, especially methyl methacrylate (MMA), and to poly(methyl methacrylate) (PMMA).

Methacrylic acid appears as a clear colorless liquid (or low-melting solid) with a pungent odor.
Methacrylic acid is Corrosive to metals and tissue.
Flash point of Methacrylic acid is 170 °F.
Melting point of Methacrylic acid is 61 °F.


Methacrylic acid May polymerize exothermically if heated or contaminated.
If the polymerization takes place inside a container, the container may rupture violently.

Methacrylic acid is Less dense than water.
Vapors of Methacrylic acid is heavier than air.
Methacrylic acid is Used to make plastics.


Methacrylic acid is an alpha,beta-unsaturated monocarboxylic acid that is acrylic acid in which the hydrogen at position 2 is substituted by a methyl group.
Methacrylic acid is functionally related to an acrylic acid.
Methacrylic acid is a conjugate acid of a methacrylate.


Methacrylic Acid (MAA) is a functional monomer, an unsaturated monocarboxylic acid.
Methacrylic Acid (MAA) reacts as a vinyl compound and as a carboxylic acid.
Methacrylic Acid (MAA) easily undergoes polymerization and addition reactions.

The copolymers of Methacrylic Acid (MAA) can be prepared with acrylic and methacrylic esters, acrylonitrile, maleic acid esters, vinyl acetate, vinyl chloride, vinylidene chloride, styrene, butadiene, ethylene, and other monomers.


Methacrylic Acid, abbreviated MAA, is an organic compound.
This colorless, viscous liquid is a carboxylic acid with an acrid unpleasant odor.
Methacrylic Acid is soluble in warm water and miscible with most organic solvents.

Methacrylic acid is produced industrially on a large scale as a precursor to its esters, especially methyl methacrylate (MMA) and poly(methyl methacrylate) (PMMA).
The methacrylates have numerous uses, most notably in the manufacture of polymers with trade names such as Lucite and Plexiglas.
MAA occurs naturally in small amounts in the oil of Roman chamomile.




FEATURES & BENEFITS OF METHACRYLIC ACID:
• Adhesive ability
• Hydrophilic
• Water solubility
• Required rheological properties


APPLICATIONS AREAS OF METHACRYLIC ACID:
Polymethacrylic Acid (PMAA) and Methacrylic Acid (MAA) copolymers are used in pulp and paper, paint and varnish, textile, medicine, in the petrochemical field and oil production as binders, film-forming agents, thickeners, adhesives, drilling reagents, dressing preparations, etc.
Methacrylic Acid (MAA) copolymers are used in the manufacture of ion exchange resins and superabsorbents.


Methacrylic Acid (MAA) is used to synthesize its esters and salts.
Methacrylic Acid is applied in the production of:
• Coatings
• Pulp & Paper
• Paint & Varnishes
• Adhesives & Sealants
• Leather & Textile
• Film-forming agents
• Thickeners
• Lubricants
• Materials used in medicine
• Plastics
• Oilfield
• Drilling agents
• Dressing preparations




PRODUCTION OF METHACRYLIC ACID:
In the most common route, methacrylic acid is prepared from acetone cyanohydrin, which is converted to methacrylamide sulfate using sulfuric acid.
This derivative in turn is hydrolyzed to methacrylic acid, or esterified to methyl methacrylate in one step. Another route to methacrylic acid starts with isobutylene, which obtainable by dehydration of tert-butanol. Isobutylene is oxidized sequentially to methacrolein and then methacrylic acid.
Methacrolein for this purpose can also be obtained from formaldehyde and ethylene.

Yet a third route involves the dehydrogenation of Isobutyric acid.
Various green routes have been explored but they have not been commercialized.
Specifically, the decarboxylation of itaconic acid, citraconic acid, and mesaconic acids affords methacrylic acid.

Salts of methacrylic acid have been obtained by boiling citra- or meso-brompyrotartaric acids with alkalis.
Pyrolysis of ethyl methacrylate efficiently gives methacrylic acid.


USES AND OCCURRENCE OF METHACRYLIC ACID:
The main use of methacrylic acid is its polymerization to poly(methyl methacrylate).
Methacrylic acid is used in some nail primers to help acrylic nails adhere to the nail plate.
Copolymers consisting partially of methacrylic acid are used in certain types of tablet coatings in order to slow the tablet's dissolution in the digestive tract, and thus extend or delay the release of the active ingredient.
MAA occurs naturally in small amounts in the oil of Roman chamomile.


REACTIONS OF METHACRYLIC ACID:
For a commercial applications, MMA is polymerized using azobisisobutyronitrile as a thermally activated free-radical catalyst.
Otherwise, MMA is relatively slow to polymerize thermally or photochemically.

Methacrylic acid undergoes several reactions characteristic of alpha,beta-unsaturated acids (see acrylic acid).

These reactions include the Diels–Alder reaction and Michael additions.
Esterifications are brought about by acid-catalyzed condensations with alcohols, alkylations with certain alkenes, and transesterifications.

Epoxide ring-opening gives hydroxyalkyl esters.
Sodium amalgam reduces it to isobutyric acid. A polymeric form of methacrylic acid was described in 1880



CHEMICAL AND PHYSICAL PROPERTIES OF METHACRYLIC ACID:
Chemical formula, C4H6O2
Molar mass, 86.09 g/mol
Appearance, Colorless liquid
Odor, Acrid, repulsive
Density, 1.015 g/cm3
Melting point, 14 to 15 °C (57 to 59 °F; 287 to 288 K)
Boiling point, 161 °C (322 °F; 434 K)
Solubility in water, 9% (25 °C)
Vapor pressure, 0.7 mmHg (20 °C)
Molecular Weight
86.09 g/mol
XLogP3
0.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
86.036779430 g/mol
Monoisotopic Mass
86.036779430 g/mol
Topological Polar Surface Area
37.3Ų
Heavy Atom Count
6
Formal Charge
0
Complexity
83.5
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Chemical nameMETHACRYLIC ACID, (MAA)
Chemical formula
CH2=C(CH3)-COOH
Concentration
Methacrylic acid 99.9% or greater (Normal concentration 100%)
Inhibitor230∼270 ppm MEHQ
CAS Number79-41-4
EINECS #201-204-4
Purity
min 99.9%
Acid Value
min 99.9%
Water content
max 0.05%
Color APHA
max 30
Physical Properties:
Appearance
Clear, colorless
Physical form
Liquid at >13°C
Odor
Pungent
Molecular weight
86 g/mol
Density
1.02 g/cm3 at 20°C
Boiling Point
163 °C
Freezing Point
16°C
Flash point
68 °C
Melting Point
16 °C
Viscosity
1.34cp at 25 °C
Vapor Point
133.3Pa 1mmHg at 25.5 °C
Color according to color reference solution Ph.Eur., colorless liquid
Assay (GC, area%), ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C), 1.013 - 1.015
Identity (IR), passes test
Melting point, 12-16 °C (lit.)
Boiling point, 163 °C (lit.)
Density, 1.015 g/mL at 25 °C (lit.)
vapor density, >3 (vs air)
vapor pressure, 1 mm Hg ( 20 °C)
refractive index, n20/D 1.431(lit.)
Flash point, 170 °F
storage temp., Store at +15°C to +25°C.
solubility, Chloroform, Methanol (Slightly)
form, Liquid
pka, pK1:4.66 (25°C)
color, Clear
Odor, Repulsive
PH, 2.0-2.2 (100g/l, H2O, 20℃)
explosive limit, 1.6-8.7%(V)
Viscosity, 1.36mm2/s
Water Solubility, 9.7 g/100 mL (20 ºC)
Sensitive, Moisture & Light Sensitive
Merck, 14,5941
BRN, 1719937
Exposure limits, TLV-TWA 20 ppm (~70 mg/m3) (ACGIH).
Stability, May be stabilized by the addition of MEHQ (Hydroquinone methyl ether, ca. 250 ppm) or hydroquinone. In the absence of a stabilizer this material will readily polymerize. Combustible. Incompatible with strong oxidizing agents, hydrochloric acid.
InChIKey, CERQOIWHTDAKMF-UHFFFAOYSA-N
LogP, 0.93 at 22℃





SAFETY INFORMATION ABOUT METHACRYLIC ACID:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product




SYNONYMS OF METHACRYLIC ACID:
2-methylacrylic acid
methacrylic acid
methacrylic acid, calcium salt
methacrylic acid, sodium salt
sodium methacrylate
METHACRYLIC ACID
79-41-4
2-Methylacrylic acid
2-methylprop-2-enoic acid
2-Propenoic acid, 2-methyl-
Methylacrylic acid
2-Methylpropenoic acid
2-Methyl-2-propenoic acid
alpha-Methylacrylic acid
2-Methylenepropionic acid
alpha-Methacrylic acid
Propionic acid, 2-methylene-
Acrylic acid, 2-methyl-
Kyselina methakrylova
Methacrylsaeure
Methakrylsaeure
25087-26-7
Acido metacrilico
Acide methacrylique
2-Methylpropensaeure
NSC 7393
CCRIS 5925
HSDB 2649
EINECS 201-204-4
BRN 1719937
DTXSID3025542
UNII-1CS02G8656
CHEBI:25219
2-Methyl-acrylic acid
AI3-15724
METHACRYLIC AC ID
NSC-7393
.alpha.-Methacrylic acid
.alpha.-Methylacrylic acid
1CS02G8656
DTXCID505542
NSC7393
EC 201-204-4
4-02-00-01518 (Beilstein Handbook Reference)
2-Methacrylic Acid
methacrylicacid
Propenoic acid, 2-methyl
Acido metacrilico [Spanish]
Acide methacrylique [French]
Kyselina methakrylova [Czech]
UN2531
Methacrylic acid (glacial)
Methacrylic acid (inhibited)
Methyl acrylic acid
No Lift Nails Primer
Methacrylic acid glacial
CH2=C(CH3)COOH
Methacrylic acid, inhibited
Methacrylic acid, stabilized
WLN: QVY1&U1
UN 2531 (Salt/Mix)
METHACRYLIC ACID [MI]
METHACRYLIC ACID [HSDB]
METHACRYLIC ACID [INCI]
CHEMBL1213531
METHACRYLIC ACID [WHO-DD]
STR02118
Tox21_200826
BBL011616
GE 110
MFCD00002651
STL163339
PROPENIONIC ACID, 2-METHYLENE
AKOS000121138
CAS-79-41-4
Methacrylic acid, inhibited (Salt/Mix)
NCGC00248843-01
NCGC00258380-01
BP-30227
BP-31229
FT-0613003
M0079
EN300-24829
Methacrylic acid, SAJ first grade, >=98.0%
Q165949
J-521686
Methacrylic acid, inhibited [UN2531] [Corrosive]
InChI=1/C4H6O2/c1-3(2)4(5)6/h1H2,2H3,(H,5,6
Methacrylic acid, contains 250 ppm MEHQ as inhibitor, 99%
25068-55-7


METHACRYLIC ACID/ACRYLIC ACID ESTER COPOLYMER,MODIFIED
Methacrylic Acid; MAA; 2-Methylenepropionic Acid; 2-Methacrylic acid; 2-Methyl-2-propenoic Acid; Acide methacrylique; Acido metacrilico; alpha-Methylacrylic acid; Kyselina methakrylova cas no: 79-41-4
Methacrylic Acid
FORMALDEHYDE, N° CAS : 50-00-0 - Méthanal / Formol, Origine(s) : Synthétique, Nom INCI : FORMALDEHYDE, Nom chimique : Formaldehyde, N° EINECS/ELINCS : 200-001-8, Additif alimentaire : E240, Ses fonctions (INCI). Antimicrobien : Aide à ralentir la croissance de micro-organismes sur la peau et s'oppose au développement des microbes
Méthanal / Formol
METHANE SULPHONIC ACID; MSA, Sulphomethane; Acide methanesulfonique; Acide methanesulfonique, Kyselina methansulfonova; Methylsulphonic acid; ácido metanosulfónico; Methansulfonsäure; cas no: 75-75-2
METHANE DICARBOXYLIC ACID (MALONIC ACID)
Methane Dicarboxylic Acid (Malonic Acid) is a dicarboxylic acid belonging to the family of carboxylic acids.
Methane Dicarboxylic Acid (Malonic Acid) (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.


CAS Number: 141-82-2
EC Number: 205-503-0
MDL number: MFCD00002707
Linear Formula: CH2(COOH)2
Molecular Formula: C3H4O4


Methane Dicarboxylic Acid (Malonic Acid) is a white crystalline substance that quickly dissolves in water and oxygenated solutions.
Methane Dicarboxylic Acid (Malonic Acid) has a breakdown temperature of 135 °C.
Methane Dicarboxylic Acid (Malonic Acid)'s ionized form, esters and salts are known as malonates, such as the diethyl malonate, which is malonic acid’s diethyl ester.


The molecular weight of Methane Dicarboxylic Acid (Malonic Acid) is 104.061 g/mol, and its density is 1.619g/cm3.
Methane Dicarboxylic Acid (Malonic Acid)'s melting point is 135 to 137°C and it decomposes above the boiling point of 140°C.
Methane Dicarboxylic Acid (Malonic Acid) or propanedioic acid is the second smallest aliphatic dicarboxylic acid with oxalic acid being the smallest.


Methane Dicarboxylic Acid (Malonic Acid) can be confused with maleic or malic acid as both contain two carboxyl groups, but it is different.
Methane Dicarboxylic Acid (Malonic Acid) differs from these two acids in terms of properties, structure, etc.
The name of this acid is derived from the Greek word Malon which means apple.


Methane Dicarboxylic Acid (Malonic Acid) on heating gives acetic acid.
French Chemist Victor Dessaignes was the first person to prepare this acid in 1858 by oxidation of malic acid.
Methane Dicarboxylic Acid (Malonic Acid)'s name originated from the Greek word Malon which means Apple.


This is because malonic or propanedioic acid is found in some fruits.
Greater concentrations of this acid in citrus are found in fruits generated in organic farming compared to fruits generated in conventional farming.
In 2004, Methane Dicarboxylic Acid (Malonic Acid) was listed by the US Department of Energy as one of the top 30 chemicals to be produced from biomass.


Methane Dicarboxylic Acid (Malonic Acid) is a dicarboxylic acid belonging to the family of carboxylic acids.
A dicarboxylic acid contains two carboxylic acid functional groups.
Usually, a dicarboxylic acid exhibits the same chemical behavior as monocarboxylic acids.


Methane Dicarboxylic Acid (Malonic Acid) naturally occurs in certain fruits.
Methane Dicarboxylic Acid (Malonic Acid) is a useful organic compound with various benefits.
Methane Dicarboxylic Acid (Malonic Acid)'s IUPAC name is propanedioic acid.


Methane Dicarboxylic Acid (Malonic Acid) should not be confused with malic or maleic acid.
Methane Dicarboxylic Acid (Malonic Acid), also known as malonate or H2MALO, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.


These are organic compounds containing exactly two carboxylic acid groups.
Methane Dicarboxylic Acid (Malonic Acid) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Methane Dicarboxylic Acid (Malonic Acid) exists in all living species, ranging from bacteria to humans.


Within humans, Methane Dicarboxylic Acid (Malonic Acid) participates in a number of enzymatic reactions.
In particular, Methane Dicarboxylic Acid (Malonic Acid) and acetic acid can be converted into acetoacetic acid; which is mediated by the enzyme fatty acid synthase.


Beta ketoacyl synthase domain: In addition, Methane Dicarboxylic Acid (Malonic Acid)and coenzyme A can be biosynthesized from malonyl-CoA through its interaction with the enzyme fatty acid synthase.
malonyl/acetyl transferase domain: An Methane Dicarboxylic Acid (Malonic Acid)in which the two carboxy groups are separated by a single methylene group.


In humans, Methane Dicarboxylic Acid (Malonic Acid) is involved in fatty acid biosynthesis.
Outside of the human body, Methane Dicarboxylic Acid (Malonic Acid) has been detected, but not quantified in, several different foods, such as red beetroots, corns, scarlet beans, common beets, and cow milks.


This could make Methane Dicarboxylic Acid (Malonic Acid) a potential biomarker for the consumption of these foods.
Methane Dicarboxylic Acid (Malonic Acid), with regard to humans, has been found to be associated with several diseases such as eosinophilic esophagitis, combined malonic and methylmalonic aciduria, and early preeclampsia; Methane Dicarboxylic Acid (Malonic Acid) has also been linked to the inborn metabolic disorder malonyl-coa decarboxylase deficiency.


Methane Dicarboxylic Acid (Malonic Acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives.
These are organic compounds containing exactly two carboxylic acid groups.
Methane Dicarboxylic Acid (Malonic Acid) (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.


The ionized form of Methane Dicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methane Dicarboxylic Acid (Malonic Acid)'s diethyl ester.
The name originates from the Greek word μλον (malon) meaning 'apple'.


Methane Dicarboxylic Acid (Malonic Acid), or propanedioic acid, is a dicarboxylic acid that forms a solid at room temperature.
Methane Dicarboxylic Acid (Malonic Acid) appears as white crystals or crystalline powder.
Methane Dicarboxylic Acid (Malonic Acid) sublimes in vacuum.


Methane Dicarboxylic Acid (Malonic Acid) appears as white crystals or crystalline powder. Sublimes in vacuum.
Methane Dicarboxylic Acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Methane Dicarboxylic Acid (Malonic Acid) has a role as a human metabolite.


Methane Dicarboxylic Acid (Malonic Acid) is an alpha,omega-dicarboxylic acid and a lipid.
Methane Dicarboxylic Acid (Malonic Acid) is a conjugate acid of a malonate(1-).
Methane Dicarboxylic Acid (Malonic Acid) (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.


The ionized form of Methane Dicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methane Dicarboxylic Acid (Malonic Acid)'s diethyl ester.
The name originates from the Greek word μᾶλον (malon) meaning 'apple'.


Methane Dicarboxylic Acid (Malonic Acid) (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionised form of Methane Dicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methane Dicarboxylic Acid (Malonic Acid)'s ethyl ester.


The name originates from Latin malum, meaning apple.
Methane Dicarboxylic Acid (Malonic Acid) (IUPAC systematic name: Propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionised form of Methane Dicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates.


For example, diethyl malonate is Methane Dicarboxylic Acid (Malonic Acid)'s ethyl ester.
The name originates from Latin malum, meaning apple.
Methane Dicarboxylic Acid (Malonic Acid) is the archetypal example of a competitive inhibitor: Methane Dicarboxylic Acid (Malonic Acid) acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.


Methane Dicarboxylic Acid (Malonic Acid) appears as white crystals or crystalline powder.
Methane Dicarboxylic Acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Methane Dicarboxylic Acid (Malonic Acid) has a role as a human metabolite.


Methane Dicarboxylic Acid (Malonic Acid) is a conjugate acid of a malonate(1-).
Methane Dicarboxylic Acid (Malonic Acid) is a dicarboxylic acid used as a precursor to certain polyesters and is a component in alkyd resins.
Methane Dicarboxylic Acid (Malonic Acid) is a dicarboxylic acid with structural formula CH2(COOH)2 and chemical formula C3H4O4.


The name Methane Dicarboxylic Acid (Malonic Acid) originated from the word ‘Malon’ which is Greek for ‘apple’.
The IUPAC name of Methane Dicarboxylic Acid (Malonic Acid) is Propanedioic acid.
Methane Dicarboxylic acid is another name for Methane Dicarboxylic Acid (Malonic Acid).


The ester and salts of Methane Dicarboxylic Acid (Malonic Acid) are called malonates.
The dicarboxylic acid has organic reactions similar to the monocarboxylic acid where amide, ester, anhydride, and chloride derivatives are formed.
Lastly, the malonic ester malonate as a coenzyme A derivative malonyl CoA that is as important a precursor as Acetyl CoA in the biosynthesis of fatty acids.


Methane Dicarboxylic Acid (Malonic Acid) has a white crystal or crystalline powder structure.
Methane Dicarboxylic Acid (Malonic Acid) is naturally occurring and can be found in many vegetables, fruits.
The dicarboxylic acid compound was first prepared by Victor Dessaignes by the oxidation reaction of malic acid.


Methane Dicarboxylic Acid (Malonic Acid) (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of Methane Dicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methane Dicarboxylic Acid (Malonic Acid)'s diethyl ester.


The name originates from the Greek word μᾶλον (malon) meaning 'apple'.
Methane Dicarboxylic Acid (Malonic Acid) (MA), also known as propanedioic acid, is a dicarboxylic acid with structure CH2(COOH)2.
Methane Dicarboxylic Acid (Malonic Acid) has three kinds of crystal forms, of which two are triclinic, and one is monoclinic.


That crystallized from ethanol is white triclinic crystals.
Methane Dicarboxylic Acid (Malonic Acid) decomposes to acetic acid and carbon dioxide at 140℃.
Methane Dicarboxylic Acid (Malonic Acid) does not decompose at 1.067×103~1.333×103Pa vacuum, but directly sublimates.


The ionised form of Methane Dicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methane Dicarboxylic Acid (Malonic Acid)'s ethyl ester.
The name originates from Latin malum, meaning apple.


Methane Dicarboxylic Acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Methane Dicarboxylic Acid (Malonic Acid) has a role as a human metabolite.
Methane Dicarboxylic Acid (Malonic Acid) is a conjugate acid of a malonate(1-).


Methane Dicarboxylic Acid (Malonic Acid) is a white crystals or crystalline powder.
Methane Dicarboxylic Acid (Malonic Acid) sublimes in vacuum.
Methane Dicarboxylic Acid (Malonic Acid) is water soluble.


Methane Dicarboxylic Acid (Malonic Acid) is a dicarboxylic acid with the chemical formula C3H4O4 and the structural formula CH2(COOH)2.
The word 'malonic acid' comes from the Greek word ‘malon', which means 'apple.'
Propanedioic acid is the IUPAC designation for Methane Dicarboxylic Acid (Malonic Acid).


Methane Dicarboxylic Acid (Malonic Acid) is also known as Methane Dicarboxylic acid.
Malonates are the ester and salts of Methane Dicarboxylic Acid (Malonic Acid).
The organic reactions of the Dicarboxylic acid are identical to those of the Monocarboxylic acid, with the formation of amide, ester, anhydride, and chloride derivatives.


Methane Dicarboxylic Acid (Malonic Acid) is the prototypical competitive inhibitor, acting against succinate dehydrogenase in the respiratory electron transport chain.
Methane Dicarboxylic Acid (Malonic Acid), also known as Carboxyacetic Acid, Dicarboxymethane, and Propanedioic Acid has the chemical formula C3H4O4.


Methane Dicarboxylic Acid (Malonic Acid) appears as a white, odorless crystal or crystalline powder.
Methane Dicarboxylic Acid (Malonic Acid) is soluble in Water, Ether, and Alcohol.
Upon heating to decomposition temperature, Methane Dicarboxylic Acid (Malonic Acid) emits irritating fumes and acrid smoke.


Propanedioic acid, or Dicarboxymethane, is another name for Methane Dicarboxylic Acid (Malonic Acid).
The name Malon is taken from a Greek word that means apple.
Malonates, as well as their esters and salts, are the ionized form of Methane Dicarboxylic Acid (Malonic Acid).


Alcohol, pyridine, and ether dissolve in Methane Dicarboxylic Acid (Malonic Acid).
By oxidizing Malic acid, the French scientist Victor Dessaignes created Methane Dicarboxylic Acid (Malonic Acid) for the first time in 1858. Some fruits, such as citrus fruits, contain Methane Dicarboxylic Acid (Malonic Acid).


The quantity of Methane Dicarboxylic Acid (Malonic Acid) generated by organically cultivated fruits is higher than that produced by conventionally grown fruits.
Glucose fermentation may be used to make Methane Dicarboxylic Acid (Malonic Acid).
Methane Dicarboxylic Acid (Malonic Acid) appears as a crystalline powder or a white crystal.



USES and APPLICATIONS of METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is a precursor to specialty polyesters.
Methane Dicarboxylic Acid (Malonic Acid) can be converted into 1,3-propanediol for use in polyesters and polymers (whose usefulness is unclear though).
Methane Dicarboxylic Acid (Malonic Acid) is a common intermediate in the pharmaceutical industry and is frequently used in veterinary medicine.


Methane Dicarboxylic Acid (Malonic Acid) is also used as a flavouring agent in certain foods.
Methane Dicarboxylic Acid (Malonic Acid) can also be a component in alkyd resins, which are used in a number of coatings applications for protecting against damage caused by UV light, oxidation, and corrosion.


One application of Methane Dicarboxylic Acid (Malonic Acid) is in the coatings industry as a crosslinker for low-temperature cure powder coatings, which are becoming increasingly valuable for heat sensitive substrates and a desire to speed up the coatings process.
The global coatings market for automobiles was estimated to be $18.59 billion in 2014 with projected combined annual growth rate of 5.1% through 2022.


Methane Dicarboxylic Acid (Malonic Acid) is used in a number of manufacturing processes as a high value specialty chemical including the electronics industry, flavors and fragrances industry, specialty solvents, polymer crosslinking, and pharmaceutical industry.
In 2004, annual global production of Methane Dicarboxylic Acid (Malonic Acid) and related diesters was over 20,000 metric tons.


Potential growth of these markets could result from advances in industrial biotechnology that seeks to displace petroleum-based chemicals in industrial applications.
In food and drug applications, Methane Dicarboxylic Acid (Malonic Acid) can be used to control acidity, either as an excipient in pharmaceutical formulation or natural preservative additive for foods.


Methane Dicarboxylic Acid (Malonic Acid) is used as a building block chemical to produce numerous valuable compounds, including the flavor and fragrance compounds gamma-nonalactone, cinnamic acid, and the pharmaceutical compound valproate.
Methane Dicarboxylic Acid (Malonic Acid) (up to 37.5% w/w) has been used to cross-link corn and potato starches to produce a biodegradable thermoplastic; the process is performed in water using non-toxic catalysts.


Starch-based polymers comprised 38% of the global biodegradable polymers market in 2014 with food packaging, foam packaging, and compost bags as the largest end-use segments.
This dicarboxylic acid, Methane Dicarboxylic Acid (Malonic Acid), finds application across various industries, including automobiles, food, fragrance, and pharmaceuticals.


Methane Dicarboxylic Acid (Malonic Acid) is used as a precursor in polyester and other polymers.
Methane Dicarboxylic Acid (Malonic Acid) is used as a flavoring agent in the fragrance industry.
Methane Dicarboxylic Acid (Malonic Acid) is suitable for controlling acidity.


Methane Dicarboxylic Acid (Malonic Acid) finds usage in pharmaceutical products.
Methane Dicarboxylic Acid (Malonic Acid) is used in the manufacture of biodegradable containers.
Methane Dicarboxylic Acid (Malonic Acid) is also a component of surgical adhesives.


Methane Dicarboxylic Acid (Malonic Acid) serves as a cross-linking agent between cornstarch and potato starch to enhance its properties.
Methane Dicarboxylic Acid (Malonic Acid) is used for the preparation of barbituric salt.
Methane Dicarboxylic Acid (Malonic Acid) is used in electroplating.


Methane Dicarboxylic Acid (Malonic Acid) is used in the production of vitamins– B1, B6, B2, and amino acids.
Methane Dicarboxylic Acid (Malonic Acid) can also be used as a component in alkyd resins.
Methane Dicarboxylic Acid (Malonic Acid) is widely used in several coating applications to protect objects against UV light damage, oxidation, and corrosion.


A common application of Methane Dicarboxylic Acid (Malonic Acid) is as a crosslinker for low-temperature powder coatings.
These are valuable for heat-sensitive substrates.
Methane Dicarboxylic Acid (Malonic Acid) is on the US Department of Energy’s list of top chemicals for biomass production.


In food and drug applications, Methane Dicarboxylic Acid (Malonic Acid) acts as a natural preservative additive for foods.
Its therapeutic uses include the prevention of resorption of bone tissue in broiler chicks by adding Methane Dicarboxylic Acid (Malonic Acid) to feed.
Methane Dicarboxylic Acid (Malonic Acid) and its esters are mainly used in pharmaceutical intermediates, spices, adhesives, resin additives, electroplating polishing agents, thermal welding flux additives, and other aspects.


Methane Dicarboxylic Acid (Malonic Acid) is used as a complexing agent and also in the preparation of barbiturate salts.
Methane Dicarboxylic Acid (Malonic Acid) is an intermediate of the fungicide rice blast and the plant growth regulator indole ester.
Methane Dicarboxylic Acid (Malonic Acid) is used in the pharmaceutical industry to produce Ruminal, Barbital, Vitamin B1, Vitamin B2, Vitamin B6, Phenylbutazone, Amino Acids, etc


As a surface treatment agent for aluminum, Methane Dicarboxylic Acid (Malonic Acid) only generates water and carbon dioxide during thermal decomposition, so there is no pollution problem.
In this regard, compared with acid type treatment agents such as formic acid used in the past, it has great advantages.


Methane Dicarboxylic Acid (Malonic Acid) is used as an intermediate in the manufacture of barbiturates and other pharmaceuticals.
Methane Dicarboxylic Acid (Malonic Acid) is a component used as a stabilizer in many high-end cosmetic and pharmaceutical products.
Methane Dicarboxylic Acid (Malonic Acid) is also used as building block in chemical synthesis, specifically to introduce the molecular group -CH2-COOH.


Methane Dicarboxylic Acid (Malonic Acid) is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation.
Methane Dicarboxylic Acid (Malonic Acid) is acts as a building block in organic synthesis.


Methane Dicarboxylic Acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which is used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methane Dicarboxylic Acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.


Methane Dicarboxylic Acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
Methane Dicarboxylic Acid (Malonic Acid) is used for the preparation of cinnamic acid, a compound used for the formation of cin metacin which is an anti-inflammatory.


The malonates are used in syntheses of B1 and B6, barbiturates, and several other valuable compounds.
Methane Dicarboxylic Acid (Malonic Acid) is used in cosmetics as a buffering and as a flavouring agent in food.
Methane Dicarboxylic Acid (Malonic Acid) is used as a component of alkyd resins, used in coating applications to protect from UV rays, oxidation, and corrosion.


Methane Dicarboxylic Acid (Malonic Acid) acts as a precursor for conversion to 1,3-propanediol, which is a compound used in polyesters and polymers with the huge market size.
Methane Dicarboxylic Acid (Malonic Acid) is a building block to many valuable compounds in food and drug applications, pharmaceutical, electronics industry, fragrances, specialty polymer, specialty solvents, and many more.


Methane Dicarboxylic Acid (Malonic Acid) is used Plating agent, Surface treating agent, Intermediate, Buffer, and Cross-linking agent.
Commercial/Industrial Applications of Methane Dicarboxylic Acid (Malonic Acid): Laboratory chemicals, Pharmaceuticals, and Paint industry.
Methane Dicarboxylic Acid (Malonic Acid) acts as a building block in organic synthesis.


Methane Dicarboxylic Acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which is used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methane Dicarboxylic Acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.


Methane Dicarboxylic Acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
Methane Dicarboxylic Acid (Malonic Acid) and its esters are mainly used in pharmaceutical intermediates, spices, adhesives, resin additives, electroplating polishing agents, thermal welding flux additives, and other aspects.


Methane Dicarboxylic Acid (Malonic Acid) is used as a complexing agent and also in the preparation of barbiturate salts.
Methane Dicarboxylic Acid (Malonic Acid) is an intermediate of the fungicide rice blast and the plant growth regulator indole ester.
Methane Dicarboxylic Acid (Malonic Acid) is used in the pharmaceutical industry to produce Ruminal, Barbital, Vitamin B1, Vitamin B2, Vitamin B6, Phenylbutazone, Amino Acids, etc.


As a surface treatment agent for aluminum, Methane Dicarboxylic Acid (Malonic Acid) only generates water and carbon dioxide during thermal decomposition, so there is no pollution problem.
In this regard, compared with acid type treatment agents such as formic acid used in the past, it has great advantages.


Methane Dicarboxylic Acid (Malonic Acid) is utilized as a precursor for the conversion of 1,3-propanediol, a widely used chemical in polyesters and polymers.
Methane Dicarboxylic Acid (Malonic Acid) is used to make cinnamic acid, which is a chemical that is utilised to make the anti-inflammatory cin metacin.


Malonates are used to make B1 and B6, barbiturates, and a variety of other useful chemicals.
Methane Dicarboxylic Acid (Malonic Acid)utilized as a buffering agent in cosmetics and as a flavoring ingredient in food items.
Methane Dicarboxylic Acid (Malonic Acid) is a component of alkyd resins, which are used to protect surfaces against UV radiation, oxidation, and corrosion.


-Biotechnological Applications of Methane Dicarboxylic Acid (Malonic Acid):
The calcium salt of Methane Dicarboxylic Acid (Malonic Acid) occurs in high concentrations in beetroot.
Methane Dicarboxylic Acid (Malonic Acid) exists in its normal state as white crystals.
Methane Dicarboxylic Acid (Malonic Acid) is the classic example of a competitive inhibitor: Methane Dicarboxylic Acid (Malonic Acid) acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.



PROPERTIES OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) molecular weight: 104.061 g.mol-1
The density of Methane Dicarboxylic Acid (Malonic Acid) is 1.619 g/cm3.
Methane Dicarboxylic Acid (Malonic Acid) appears as a crystalline powder that is white or colourless.

At the boiling point above 140oC Methane Dicarboxylic Acid (Malonic Acid) decomposes.
The melting point of Methane Dicarboxylic Acid (Malonic Acid) is 135-137o C.
If heated to decomposition under fire Methane Dicarboxylic Acid (Malonic Acid) emits carbon oxide fumes and acrid irritating smoke.
Acidity of Methane Dicarboxylic Acid (Malonic Acid) is pKa = 2.85 at 25oC. pKa1 = 2.83, pKa2 = 5.69

The molar heat of combustion of Methane Dicarboxylic Acid (Malonic Acid) is 864 kJ/mol.
The heat of vaporization of Methane Dicarboxylic Acid (Malonic Acid) is 92 kJ/mol.
Methane Dicarboxylic Acid (Malonic Acid) is soluble in water.
Solubility of Methane Dicarboxylic Acid (Malonic Acid) is 763 g/L.



METHANE DICARBOXYLIC ACID (MALONIC ACID) STRUCTURAL FORMULA:
Methane Dicarboxylic Acid (Malonic Acid) Lewis structure has been found by the X-ray crystallography method.
The Methane Dicarboxylic Acid (Malonic Acid) structure CH2(COOH)2 has two carboxylic acids.
The salts and esters of malonic acid (malonates) have structures similar to Methane Dicarboxylic Acid (Malonic Acid).



BIOLOGICAL FUNCTIONS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.
Methane Dicarboxylic Acid (Malonic Acid) binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the ?CH2CH2? group required for dehydrogenation.
This observation was used to deduce the structure of the active site in succinate dehydrogenase.



STRUCTURE OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The X-ray crystallography technique was used to discover the Lewis structure of Methane Dicarboxylic Acid (Malonic Acid).
Methane Dicarboxylic Acid (Malonic Acid) has two Carboxylic Acids in its structure CH2(COOH)2.
Methane Dicarboxylic Acid (Malonic Acid) salts and esters (malonates) have structures that are comparable to malonic acid.



SIGNIFICANCE OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is an example of a competitive inhibitor.
Methane Dicarboxylic Acid (Malonic Acid) functions in the ETS chain against succinate dehydrogenase in respiration.
Methane Dicarboxylic Acid (Malonic Acid) is related to a deficiency of malonyl-CoA decarboxylase that leads to an inborn metabolism mistake.
Methane Dicarboxylic Acid (Malonic Acid) serves as a potential biomarker for tracking foods that contain malonic acids.
Methane Dicarboxylic Acid (Malonic Acid) finds usage in various industries.



SYNTHESIS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The synthesis of Methane Dicarboxylic Acid (Malonic Acid) usually begins with chloroacetic acid.
Methane Dicarboxylic Acid (Malonic Acid) is also synthesized by cyanoacetic acid or by acid saponification reaction of malonates.
From monochloroacetic acid, Methane Dicarboxylic Acid (Malonic Acid) is produced by sodium or potassium cyanide.

The sodium carbonate primarily breaks down to give sodium salt which reacts with sodium cyanide to give sodium salt of cyanoacetic acid by the process of nucleophilic substitution.
Further, via hydrolyzation, the nitrile group binds with sodium malonate, whose acidification results in the production of Methane Dicarboxylic Acid (Malonic Acid).



PURIFICATION METHODS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Crystallise Methane Dicarboxylic Acid (Malonic Acid) from *benzene/diethyl ether (1:1) containing 5% of pet ether (b 60-80o), wash with diethyl ether, then recrystallise it from H2O or acetone.
Dry Methane Dicarboxylic Acid (Malonic Acid) under vacuum over conc H2SO4



METHANE DICARBOXYLIC ACID (MALONIC ACID) FORMULA:
The Methane Dicarboxylic Acid (Malonic Acid) formula is C3H4O4.
Methane Dicarboxylic Acid (Malonic Acid) is also called propanedioic acid or dicarboxymethane, and the formula is written as CH₂(COOH)₂.



REACTIONS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
In a well - known reaction, malonic acid condenses with urea to form barbituric acid.
Methane Dicarboxylic Acid (Malonic Acid) is also frequently used as an enolate in Knoevenagel condensations or condensed with acetone to form Meldrum's acid.
The esters of Methane Dicarboxylic Acid (Malonic Acid) are also used as a - CH2COOH synthon in the malonic ester synthesis.



HISTIRY OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
In 1858, Methane Dicarboxylic Acid (Malonic Acid) was prepared for the first time by a French chemist –Victor Dessaignes.
He oxidized malic acid with potassium dichromate, which is a strong oxidizing agent.
Later Methane Dicarboxylic Acid (Malonic Acid) was found to occur in some fruits viz citrus fruits.
Methane Dicarboxylic Acid (Malonic Acid) can also be produced by fermenting glucose.



CALCULATION OF MOLECULAR WEIGHT OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The formula of malonic acid is C3H4O4.
The atomic weight of carbon is 12.011.
The atomic weight of oxygen is 15.999.
The atomic weight of hydrogen is 1.00784.

So, its molar mass can be calculated as follows:
= (3 × 12.011) + (4 × 1.00784) + (4 × 15.999)
= 36.033 + 4. 03136 + 63.996
= 104.06 grams/ mol
Thus, the molar mass or molecular weight of Methane Dicarboxylic Acid (Malonic Acid) is 104.061 g/mol.



CHEMICAL PROPERTIES OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The chemical properties of Methane Dicarboxylic Acid (Malonic Acid) are as follows:
On Heating
When Methane Dicarboxylic Acid (Malonic Acid) is heated, it gives acetic acid and carbon dioxide.
Reaction with Phosphorus Pentoxide
On heating a dry mixture of Methane Dicarboxylic Acid (Malonic Acid) and phosphorus pentoxide, carbon suboxide is prepared.



PREPARATION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) can be prepared with chloroacetic acid (also called mono chloroacetic acid).
Sodium carbonate gives sodium salt.
The salt reacts with sodium cyanide.
Nucleophilic substitution reaction gives rise to cyanoacetic acid salt.

The nitrile group is hydrolyzed with NaOH to produce sodium malonate.
The acidification of sodium malonate gives Methane Dicarboxylic Acid (Malonic Acid).
The following diagram represents the steps mentioned above:

*Industrial Preparation:
Methane Dicarboxylic Acid (Malonic Acid) can also be produced by hydrolyzing diethyl malonate or dimethyl malonate.



FORMULA OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is a dicarboxylic acid with the chemical formula C3H4O4 and structural formula CH2(COOH)2
Propanedioic acid is the IUPAC name of Methane Dicarboxylic Acid (Malonic Acid), and another name for the acid is Methane Dicarboxylic acid. Malonates are its esters and salts.
There are three carbons with four hydrogen molecules and four oxygen molecules attached.
The two OH groups are attached with two carbons.



PHYSICAL PROPERTIES OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Solubility: Dissolves in alcohol, pyridine, and ether.
Molecular Wt/ Molar Mass: 104.06 g/mol
Density: 1.619 g/cm³
Boiling Point: Decomposes
Melting Point: 135 to 137°C
Nature: Acidic
Color: White
Stability: Usually stable under recommended conditions
Molar heat of combustion: 864 kJ/mol
The heat of vaporization: 92 kJ/mol
Methane Dicarboxylic Acid (Malonic Acid) does not have a chiral center.
So, Methane Dicarboxylic Acid (Malonic Acid) doesn’t exhibit optical isomerism.
Methane Dicarboxylic Acid (Malonic Acid) is a hygroscopic solid that sublimes in a vacuum.



DID YOU KNOW, METHANE DICARBOXYLIC ACID (MALONIC ACID):
Several food substances contain Methane Dicarboxylic Acid (Malonic Acid), including:
● Red beetroots
● Corns
● Common beets
● Scarlet beans
● Cow’s milk
Its occurrence in food items makes Methane Dicarboxylic Acid (Malonic Acid) a potential biomarker indicating the consumption of these foods.



ALTERNATIVE PARENTS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
*1,3-dicarbonyl compounds
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives



SUBSTITUENTS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
*1,3-dicarbonyl compound
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



CHEMICAL PROPERTIES OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is a white crystalline solid that decomposes at approximately 135°C.
Methane Dicarboxylic Acid (Malonic Acid) has high solubility in water and oxygenated solvents and exhibits greater acidity than acetic acid, which has a pK value of 4.75.
The pKa values for the loss of Methane Dicarboxylic Acid (Malonic Acid)'s first and second protons are 2.83 and 5.69, respectively.

Methane Dicarboxylic Acid (Malonic Acid) is slightly soluble in pyridine.
Methane Dicarboxylic Acid (Malonic Acid) can decompose to formic acid and carbon dioxide in case of potassium permanganate.
Since Methane Dicarboxylic Acid (Malonic Acid) generates carbon dioxide and water after heated without pollution problems, it can be directly used as aluminum surface treatment agent.



PREPARATION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is usually produced from chloroacetic acid.



REACTION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The chloroacetic acid is added to the reaction kettle by adding sodium carbonate aqueous solution to generate sodium chloroacetate aqueous solution, and then 30% sodium cyanide solution is slowly added dropwise, and the reaction is carried out at a predetermined temperature to generate sodium cyanoacetate.
After the cyanation reaction is completed, add sodium hydroxide for heating and hydrolysis to generate sodium malonate solution, concentrate, then dropwise add sulfuric acid for acidification to generate Methane Dicarboxylic Acid (Malonic Acid), filter and dry to obtain the product.



PREPARATION OF METHANE DICARBOXYLIC ACID (MALONIC ACID) FROM CHLOROACETIC ACID:
This method often does not produce a pure enough product or the pure product has an extremely low yield.
Industrially, Methane Dicarboxylic Acid (Malonic Acid) is also produced by hydrolyzing dimethyl malonate or diethyl malonate.
This manufacturing method is able to bring about a higher yield and purity, but the organic synthesis of Methane Dicarboxylic Acid (Malonic Acid) through these processes is extremely costly and environmentally hazardous.



RELATED COMPOUNDS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
*Other anions
Malonate
*Related carboxylic acids
Oxalic acid
Propionic acid
Succinic acid
Fumaric acid
*Related compounds
Malondialdehyde
Dimethyl malonate



PATHOLOGY OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
If elevated Methane Dicarboxylic Acid (Malonic Acid) levels are accompanied by elevated methylmalonic acid levels, this may indicate the metabolic disease combined malonic and methylmalonic aciduria (CMAMMA).
By calculating the Methane Dicarboxylic Acid (Malonic Acid) to methylmalonic acid ratio in blood plasma, CMAMMA can be distinguished from classic methylmalonic acidemia.



BIOCHEMISTRY OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.
Methane Dicarboxylic Acid (Malonic Acid) binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the −CH2CH2− group required for dehydrogenation.

This observation was used to deduce the structure of the active site in succinate dehydrogenase.
Inhibition of this enzyme decreases cellular respiration.
Since Methane Dicarboxylic Acid (Malonic Acid) is a natural component of many foods, it is present in mammals including humans.



RELATED CHEMICALS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The fluorinated version of malonic acide is difluoromalonic acid
Methane Dicarboxylic Acid (Malonic Acid) is diprotic; that is, it can donate two protons per molecule.
Methane Dicarboxylic Acid (Malonic Acid)'s first is 2.8 and the second is 5.7.
Thus the malonate ion can be HOOCCH2COO− or CH2(COO)2−2.

Malonate or propanedioate compounds include salts and esters of Methane Dicarboxylic Acid (Malonic Acid), such as:
*Diethyl malonate
*Dimethyl malonate
*Disodium malonate
*Malonyl-CoA



ORGANIC REACTIONS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) reacts as a typical carboxylic acid: forming amide, ester, anhydride, and chloride derivatives.
Malonic anhydride can be used as an intermediate to mono-ester or amide derivatives, while malonyl chloride is most useful to obtain diesters or diamides.

In a well-known reaction, Methane Dicarboxylic Acid (Malonic Acid) condenses with urea to form barbituric acid.
Methane Dicarboxylic Acid (Malonic Acid) may also be condensed with acetone to form Meldrum's acid, a versatile intermediate in further transformations.
The esters of Methane Dicarboxylic Acid (Malonic Acid) are also used as a −CH2COOH synthon in the malonic ester synthesis.

Mitochondrial fatty acid synthesis
Methane Dicarboxylic Acid (Malonic Acid) is the starting substrate of mitochondrial fatty acid synthesis (mtFASII), in which it is converted to malonyl-CoA by malonyl-CoA synthetase (ACSF3).

Additionally, the coenzyme A derivative of malonate, malonyl-CoA, is an important precursor in cytosolic fatty acid biosynthesis along with acetyl CoA.
Malonyl CoA is formed there from acetyl CoA by the action of acetyl-CoA carboxylase, and the malonate is transferred to an acyl carrier protein to be added to a fatty acid chain.

Briggs–Rauscher reaction
Methane Dicarboxylic Acid (Malonic Acid) is a key component in the Briggs–Rauscher reaction, the classic example of an oscillating chemical reaction.



KNOEVENAGEL CONDENSATION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
In Knoevenagel condensation, Methane Dicarboxylic Acid (Malonic Acid) or its diesters are reacted with the carbonyl group of an aldehyde or ketone, followed by a dehydration reaction.
Z=COOH (Methane Dicarboxylic Acid (Malonic Acid)) or Z=COOR' (malonate ester)

When Methane Dicarboxylic Acid (Malonic Acid) itself is used, it is normally because the desired product is one in which a second step has occurred, with loss of carbon dioxide, in the so-called Doebner modification.
The Doebner modification of the Knoevenagel condensation.
Thus, for example, the reaction product of acrolein and Methane Dicarboxylic Acid (Malonic Acid) in pyridine is trans-2,4-Pentadienoic acid with one carboxylic acid group and not two.



PREPARATION OF CARBON SUBOXIDE FROM METHANE DICARBOXYLIC ACID (MALONIC ACID):
Carbon suboxide is prepared by warming a dry mixture of phosphorus pentoxide (P4O10) and Methane Dicarboxylic Acid (Malonic Acid).
Methane Dicarboxylic Acid (Malonic Acid) reacts in a similar way to malonic anhydride, forming malonates.



BIOCHEMISTRY OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The calcium salt of Methane Dicarboxylic Acid (Malonic Acid) occurs in high concentrations in beetroot.
It exists in its normal state as white crystals.



ORGANIC SYNTHESIS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
A classical preparation of Methane Dicarboxylic Acid (Malonic Acid) starts from acetic acid.
Methane Dicarboxylic Acid (Malonic Acid) is chlorinated to chloroacetic acid.
Sodium carbonate generates the sodium salt which is then reacted with sodium cyanide to the cyano acetic acid salt in a nucleophilic substitution.
The nitrile group can be hydrolysed with sodium hydroxide to sodium malonate and acidification affords Methane Dicarboxylic Acid (Malonic Acid).



ORGANIC REACTIONS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
In a well known reaction Methane Dicarboxylic Acid (Malonic Acid) condenses with urea to barbituric acid.
Methane Dicarboxylic Acid (Malonic Acid) is frequently used as an enolate in Knoevenagel condensations or condensed with acetone to form Meldrum's acid.
Its esters are also used for the -CH2COOH synthon in the malonic ester synthesis.



SYNTHESIS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Chloroacetic acid is generally used to start the production of Methane Dicarboxylic Acid (Malonic Acid).
Methane Dicarboxylic Acid (Malonic Acid) can also be made from cyanoacetic acid or the acid saponification of malonates.
Methane Dicarboxylic Acid (Malonic Acid) is made from monochloroacetic acid and sodium or potassium cyanide.
By the process of Nucleophilic Substitution, sodium carbonate breaks down to provide sodium salt, which combines with sodium cyanide to give sodium salt of cyanoacetic acid.
Furthermore, the nitrile group attaches to sodium malonate through hydrolysis, resulting in the formation of Methane Dicarboxylic Acid (Malonic Acid).



STRUCTURE AND PREPARATION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The structure of Methane Dicarboxylic Acid (Malonic Acid) has been determined by X-ray crystallography and extensive property data including for condensed phase thermochemistry are available from the National Institute of Standards and Technology.
A classical preparation of Methane Dicarboxylic Acid (Malonic Acid) starts from chloroacetic acid:


*Preparation of Methane Dicarboxylic Acid (Malonic Acid) from chloroacetic acid:
Sodium carbonate generates the sodium salt, which is then reacted with sodium cyanide to provide the sodium salt of cyanoacetic acid via a nucleophilic substitution.
The nitrile group can be hydrolyzed with sodium hydroxide to sodium malonate, and acidification affords Methane Dicarboxylic Acid (Malonic Acid).
Industrially, however, Methane Dicarboxylic Acid (Malonic Acid) is produced by hydrolysis of dimethyl malonate or diethyl malonate.
Methane Dicarboxylic Acid (Malonic Acid)has also been produced through fermentation of glucose.



OCCURRENCE OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is an organic compound naturally found in some fruits.
Fruits produced in organic farming have greater concentrations of Methane Dicarboxylic Acid (Malonic Acid) than those generated from conventional farming practices.

Methane Dicarboxylic Acid (Malonic Acid) is often found in some citrus fruits and vegetables.
Methane Dicarboxylic Acid (Malonic Acid) is a component of food items, it is present in animals, including humans.

The name of this acid is derived from the Greek word Malon.
It means apple.
The ionized form of Methane Dicarboxylic Acid (Malonic Acid) is malonate, along with its salts and esters.
Methane Dicarboxylic Acid (Malonic Acid) occurs as a white crystal or crystalline powder in nature.



HISTORY OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is a naturally occurring substance found in many fruits and vegetables.
There is a suggestion that citrus fruits produced in organic farming contain higher levels of Methane Dicarboxylic Acid (Malonic Acid) than fruits produced in conventional agriculture.
Methane Dicarboxylic Acid (Malonic Acid) was first prepared in 1858 by the French chemist Victor Dessaignes via the oxidation of malic acid.



DECOMPOSITION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) has hazardous decomposition products under fire conditions, including carbon oxides.
Also, when heated, Methane Dicarboxylic Acid (Malonic Acid) decomposes and emits acrid smoke in addition to irritating fumes.



ORGANIC REACTIONS OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) reactions are usually similar to a typical carboxylic acid.
Methane Dicarboxylic Acid (Malonic Acid) forms amide, anhydrides, esters, and chloride derivatives on reacting with specific reactants.
Malonic anhydride serves as an intermediate in the formation of amide derivatives.

Malonyl chloride is widely used for obtaining diamides or diesters.
Some of the popular organic reactions involving Methane Dicarboxylic Acid (Malonic Acid) are as follows:
Methane Dicarboxylic Acid (Malonic Acid) condenses with urea to give barbituric acid.
Methane Dicarboxylic Acid (Malonic Acid) also condenses with acetone to produce Meldrum’s acid.

Methane Dicarboxylic Acid (Malonic Acid) is a versatile intermediate and helps in further transformations.
Malonate’s coenzyme A derivative— malonyl-CoA, acts as an important precursor in fatty acid biosynthesis.
It is formed from acetyl CoA when it is acted upon by acetyl-CoA carboxylase.
The malonate gets transferred to an acyl carrier protein for its addition to the fatty acid chain.



BRIGGS-RAUSCHER REACTION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
A popular name reaction has Methane Dicarboxylic Acid (Malonic Acid) as its key component.
Methane Dicarboxylic Acid (Malonic Acid) is an example of an oscillating chemical reaction.



KNOEVENAGEL CONDENSATION OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
The reaction is a modification of the aldol condensation reaction (the reaction between benzaldehyde and acetophenone).
It involves the interaction of Methane Dicarboxylic Acid (Malonic Acid) or its diesters with the carbonyl group of a ketone or an aldehyde.
This process is followed by a dehydration reaction.



REACTIVITY PROFILE OF METHANE DICARBOXYLIC ACID (MALONIC ACID):
Methane Dicarboxylic Acid (Malonic Acid) is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0.
Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.

Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.
Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.

Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.
Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.

A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions
Methane Dicarboxylic Acid (Malonic Acid) is incompatible with strong oxidizers.
Methane Dicarboxylic Acid (Malonic Acid) is also incompatible with bases and reducing agents.



PHYSICAL and CHEMICAL PROPERTIES of METHANE DICARBOXYLIC ACID (MALONIC ACID):
CAS Number: 141-82-2
Molecular Weight: 104.06
Beilstein: 1751370
MDL number: MFCD00002707
Molecular Weight: 104.06 g/mol
XLogP3: -0.8
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 104.01095860 g/mol
Monoisotopic Mass: 104.01095860 g/mol
Topological Polar Surface Area: 74.6Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 83.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0

Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: powder
Color: white
Odor: odorless
Melting point/freezing point:
Melting point: >= 135 °C
Initial boiling point and boiling range: 215 °C at 18,66 hPa (decomposition)
Flammability (solid, gas): The product is not flammable.
Upper/lower flammability or explosive limits: No data available
Flash point: 157 °C - c.c.
Autoignition temperature: No data available
Decomposition temperature: > 140 °C
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility 766 g/l at 20 °C
Partition coefficient:
n-octanol/water:
log Pow: -0,81 - Bioaccumulation is not expected.
Vapor pressure: 0,002 hPa at 25 °C
Density: 1,6 g/cm3

Relative density: 1,03 at 20 °C
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
CAS Number: 141-82-2
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7) check
Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
InChI=1/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
Key: OFOBLEOULBTSOW-UHFFFAOYAJ
SMILES: O=C(O)CC(O)=O
C(C(=O)O)C(=O)O
Chemical formula: C3H4O4
Molar mass: 104.061 g·mol−1
Density: 1.619 g/cm3
Melting point: 135 to 137 °C (275 to 279 °F; 408 to 410 K) (decomposes)
Boiling point: decomposes
Solubility in water: 763 g/L
Acidity (pKa): pKa1 = 2.83

pKa2 = 5.69
Magnetic susceptibility (χ): -46.3·10−6 cm3/mol
Chemical Formula: C3H4O4
Average Molecular Weight: 104.0615
Monoisotopic Molecular Weight: 104.010958616
IUPAC Name: propanedioic acid
Traditional Name: malonic acid
CAS Registry Number: 141-82-2
SMILES: OC(=O)CC(O)=O
InChI Identifier: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
InChI Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
Molecular Weight: 104.06100
Exact Mass: 104.06
EC Number: 205-503-0
UNII: 9KX7ZMG0MK
ICSC Number: 1085
NSC Number: 8124
DSSTox ID: DTXSID7021659
Color/Form: White crystals|Crystalline powder
Colorless hygroscopic solid which sublimes in vacuum
HScode: 2917190090
PSA: 74.60000
XLogP3: -0.8

Appearance: Malonic acid appears as white crystals or crystalline powder.
Sublimes in vacuum.
Density: 1.6 g/cm3
Melting Point: 135 °C (decomp)
Boiling Point: 215 °C @ Press: 14 Torr
Flash Point: 201.9ºC
Refractive Index: 1.479
Water Solubility: H2O: 1400 g/L (20 ºC)
Storage Conditions: Store at RT.
Vapor Pressure: 4.66E-07mmHg at 25°C
PKA: 2.85(at 25 °C)
Dissociation Constants: 2.85 (at 25 °C)|pKa1 = 2.8, pKa2 = 5.7 at 25 °C
Experimental Properties:
Enthalpy of Sublimation: 72.7 kJ/mol at 306 deg K, 108.0 kJ/mol at 348 deg K
Henry's Law constant = 4.8X10-13 atm-cu m/mole at 23 °C
(estimated from vapor pressure and water solubility)
Hydroxyl radical reaction rate constant = 1.6X10-12 cu-cm/molc sec at 25 °C (est)
Air and Water Reactions: Water soluble.
Reactive Group: Acids, Carboxylic
Heat of Combustion: Molar heat of combustion: 864 kJ/mol

Heat of Vaporization: 92 kJ/mol
Critical Temperature & Pressure:
Critical temperature: 805 K (estimated);
critical pressure: 5640 kPa (estimated)
CAS: 141-82-2
Molecular Formula: C3H4O4
Molecular weight: 104.06
EINECS: 205-503-0
Purity: ≥99%
Appearance: White crystal powder
Melting point: 132-135 °C (dec.) (lit.)
Boiling point: 140ºC(decomposition)
Density: 1.619 g/cm3 at 25 °C
Refractive index: 1.478
Flash Point: 157°C
Storage condition: Sealed in dry,Room Temperature
Solubility : 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
Pka: 2.83(at 25ºC)
Stability: Stable.
Incompatible with oxidizing agents, reducing agents, bases.
HS Code: 29171910
PH: 3.17(1 mM solution);2.5(10 mM solution);
1.94(100 mM solution)

MDL: MFCD00002707
Water Solubility: 1400 g/L (20 ºC)
Vapor Presure: 0-0.2Pa at 25ºC
Physical and Chemical Properties:
Character: white crystal.
soluble in water, soluble in ethanol and ether, pyridine.
Color: White
Formula Weight: 104.1
Percent Purity: 0.99
Physical Form: Powder
Chemical Name or Material: Malonic acid
Melting point: 132-135 °C (dec.) (lit.)
Boiling point: 140℃(decomposition)
Density: 1.619 g/cm3 at 25 °C
vapor pressure: 0-0.2Pa at 25℃
refractive index: 1.4780
Flash point: 157°C
storage temp.: Sealed in dry,Room Temperature
solubility: 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
form: Liquid

pka: 2.83(at 25℃)
color: White
PH: 3.17(1 mM solution);2.5(10 mM solution);1.94(100 mM solution)
Water Solubility: 1400 g/L (20 ºC)
Merck: 14,5710
BRN: 1751370
Stability: Stable.
Incompatible with oxidizing agents, reducing agents, bases.
InChIKey: OFOBLEOULBTSOW-UHFFFAOYSA-N
LogP: -0.81
CAS DataBase Reference: 141-82-2(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 9KX7ZMG0MK
NIST Chemistry Reference: Malonic acid(141-82-2)
EPA Substance Registry System: Propanedioic acid (141-82-2)



FIRST AID MEASURES of METHANE DICARBOXYLIC ACID (MALONIC ACID):
Description of first-aid measures
-General advice
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed
No data available



ACCIDENTAL RELEASE MEASURES of METHANE DICARBOXYLIC ACID (MALONIC ACID):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of METHANE DICARBOXYLIC ACID (MALONIC ACID):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water
system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of METHANE DICARBOXYLIC ACID (MALONIC ACID):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of METHANE DICARBOXYLIC ACID (MALONIC ACID):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
*Storage class:
Storage class (TRGS 510): 13:
Non Combustible Solids



STABILITY and REACTIVITY of METHANE DICARBOXYLIC ACID (MALONIC ACID):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .



SYNONYMS:
1,3-Propanedioic acid
Carboxyacetic acid
Dicarboxymethane
Methanedicarboxylic acid
Propanedioic acid
malonic acid
propanedioic acid
141-82-2
Dicarboxymethane
Carboxyacetic acid
Methanedicarboxylic acid
malonate
Kyselina malonova
USAF EK-695
1,3-Propanedioic acid
Dicarboxylate
Malonicacid
Dicarboxylic acid
NSC 8124
UNII-9KX7ZMG0MK
9KX7ZMG0MK
AI3-15375
H2malo
EINECS 205-503-0
MFCD00002707
BRN 1751370
Methanedicarbonic acid
CHEBI:30794
Thallium malonate
HOOC-CH2-COOH
NSC-8124
Propane-1,3-dioic acid
alpha,omega-Dicarboxylic acid
DTXSID7021659
HSDB 8437
NSC8124
4-02-00-01874 (Beilstein Handbook Reference)
1,3-Propanoic acid
PROPANEDIOLIC ACID
METAHNEDICARBOXYLIC ACID
C3H4O4
2fah
MLI
Malonic acid, 99%
Malonic acid (8CI)
1o4m
Malonate dicarboxylic acid
Malonic acid, 99.5%
Propanedioic acid (9CI)
SCHEMBL336
WLN: QV1VQ
MALONIC ACID [MI]
CH2(COOH)2
CHEMBL7942
MALONIC ACID [INCI]
DTXCID401659
SCHEMBL1471092
BDBM14673
Propanedioic acid dithallium salt
Malonic acid, analytical standard
AMY11201
BCP05571
STR00614
Tox21_200534
AC8295
LMFA01170041
s3029
Malonic acid, ReagentPlus(R), 99%
AKOS000119034
CS-W019962
DB02175
PROPANEDIOIC ACID MALONIC ACID
NCGC00248681-01
NCGC00258088-01
BP-11453
CAS-141-82-2
SY001875
Malonic acid, SAJ first grade, >=99.0%
FT-0628127
FT-0628128
FT-0690260
FT-0693474
M0028
EN300-18457
Malonic acid, Vetec(TM) reagent grade, 98%
C00383
C02028
C04025
Q421972
J-521669
Z57965450
F1908-0177
Malonic acid, certified reference material, TraceCERT(R)
592A9849-68C3-4635-AA3D-CBC44965EA3A
Malonic acid, sublimed grade, >=99.95% trace metals basis
DICARBOXYLIC ACID C3
PROPANEDIOLIC ACID
METHANEDICARBOXYLIC ACID
InChI=1/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7
Malonic acid, anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), 99%
LML
Propanedioic acid
Methanedicarboxylic acid
H2Malo
HOOC-CH2-COOH
Propanedioic acid
Propanedioate
Malonate
alpha,Omega-dicarboxylic acid
Carboxyacetic acid
Dicarboxylate
Dicarboxylic acid
Dicarboxymethane
Kyselina malonova
Malonate dicarboxylic acid
Metahnedicarboxylic acid
Methanedicarbonic acid
Methanedicarboxylic acid
Propanedioic acid dithallium salt
Propanediolic acid
Thallium malonate
Malonic acid, 2-(14)C-labeled
Malonic acid, monocalcium salt
Malonic acid, 1,3-(14)C2-labeled
Malonic acid, diammonium salt
Malonic acid, disodium salt
Malonic acid, dithallium salt
Malonic acid, dipotassium salt
Malonic acid, disodium salt, 1-(14)C-labeled
Malonic acid, monosodium salt
Malonic acid, potassium salt
Malonic acid, sodium salt
Thallous malonate
Dithallium malonate
Monosodium malonate
Malonic acid
Malonic acid
Carboxyacetic acid
Dicarboxymethane
Methanedicarboxylic acid
CH2(COOH)2
USAF EK-695
Kyselina malonova
Methanedicarbonic acid
NSC 8124
Propanedioic acid
Malonic acid
Carboxyacetic acid
Dicarboxymethane
Methanedicarboxylic acid
1,3-Propanedioic acid
NSC 8124
Malonates
211863-95-5
alpha,Omega-dicarboxylic acid
Carboxyacetic acid
Dicarboxylate
Dicarboxylic acid
Dicarboxymethane
H2Malo
HOOC-CH2-COOH
Kyselina malonova
Malonate
Malonate dicarboxylic acid
Malonic acid, 1,3-(14)C2-labeled
Malonic acid, 2-(14)C-labeled
Malonic acid, diammonium salt
Malonic acid, dipotassium salt
Malonic acid, disodium salt
Malonic acid, disodium salt, 1-(14)C-labeled
Malonic acid, dithallium salt
Malonic acid, monocalcium salt
Malonic acid, monosodium salt
Malonic acid, potassium salt
Malonic acid, sodium salt
Metahnedicarboxylic acid
Methanedicarbonic acid
Methanedicarboxylic acid
Propanedioate
Propanedioic acid
Propanedioic acid dithallium salt
Propanediolic acid
Thallium malonate
Thallous malonate
Dithallium malonate
Monosodium malonate
Malonic acid
PROPANEDIOIC ACID
MAAC
Daucic acid
CH2(COOH)2
Methane acid
Propandioic acid
Methanedicarbonic acid
METHANEDICARBOXYLIC ACID
MALONIC ACID
Malonsure
Propanedioic acid
Malonic acid
Carboxyacetic acid
Dicarboxymethane
Methanedicarboxylic acid
CH2(COOH)2
usaf ek-695
Kyselina malonova
Methanedicarbonic acid
Malonic acid
Propanedioic acid
Carboxy Acetic acid
Dicarboxymethane
Methane dicarboxylic acid
Dicarboxylate
Dicarboxylic acid
1,3-Propanedioic acid
Methane dicarbonic acid
Propane-1,3-dioic acid




METHANE SULFONIC ACID (MSA 70%)

Methane Sulfonic Acid (MSA 70%) is a strong organic acid with the chemical formula CH3SO3H.
Methane Sulfonic Acid (MSA 70%) is a colorless liquid and is miscible with water and many organic solvents.
Methane Sulfonic Acid (MSA 70%) is often encountered in its solution form, and the term "MSA 70%" refers to a solution where the MSA is present at a concentration of 70%.

CAS Number: 75-75-2
EC Number: 200-898-6

MSA, Methanesulfonic acid, Methylsulfonic acid, Methanesulphonic acid, Methylsulphonic acid, MSIA, Sulfonmethane, Sulphonic acid, methane, Sulfonic acid, methyl, Caromet, Methansulfonic acid, Methanesulfonate, Monomethyl sulfonic acid, Mesylic acid, C1 Sulfonate, C1-sulfonate, Aci-jel, Mesylicum, Mesylsaeure, Sulfonic acid, C1, C1-sulfonic acid, MSA (acid), C1-sulfuric acid, Carerite FA, Methylsulfonate, Methansulfonate, Methyl sulfuric acid, Sulfonic acid (C1), Ameisensaeure, C1 sulfonic acid, Carerite FA-80, Methyl sulfonic acid, Methane sulphonic acid, Carerite MSA, C1 Sulfonic acid, Sulfonic acid, C1-4, Carerite FA 1:1, Mesylic acid, anhydrous, Ameisensaeure (German), Sulfonic acid (C1-4), Aci-jel solution, Mesylate, Carerite FA 1:1 solution, Carerite FA solution, Ameisensaeure (German), C1-Sulfonic acid, Methanesulphonic acid, monohydrate, Carerite MSA 80, Methanesulfonic acid, solution, Mesylic acid, monohydrate, Carerite FA-80 solution, Ameisensaeure (German), Carerite FA-80 solution, C1-Sulfuric acid, Methanesulphonic acid, 70% solution, Methylsulfonic acid, 70% solution, MSA, 70% solution, Methanesulphonic acid, solution, Methanesulfonic acid, 70% solution, Methylsulfonic acid, 70% solution



APPLICATIONS


Methane Sulfonic Acid (MSA 70%) is commonly used as a catalyst in organic synthesis reactions, promoting various chemical transformations.
Methane Sulfonic Acid (MSA 70%) serves as an acid catalyst in esterification processes, facilitating the formation of esters from carboxylic acids and alcohols.
Methane Sulfonic Acid (MSA 70%) is employed in the production of pharmaceuticals, where it plays a crucial role in synthesizing key intermediates.

In the field of polymerization, MSA is utilized as a catalyst to initiate polymer chain reactions, particularly in the synthesis of specialty polymers.
Methane Sulfonic Acid (MSA 70%) finds application in the synthesis of fine chemicals, contributing to the development of high-value compounds.

Methane Sulfonic Acid (MSA 70%) is used as a strong acid in certain electrophilic substitution reactions, enhancing reaction rates and selectivity.
In electroplating processes, MSA serves as an additive in electrolytes, aiding in the deposition of metal coatings on surfaces.
Methane Sulfonic Acid (MSA 70%) is employed as a corrosion inhibitor in various industrial processes, protecting metals from degradation in corrosive environments.

Methane Sulfonic Acid (MSA 70%) is utilized in the production of surfactants and detergents, contributing to the formulation of cleaning agents.
Methane Sulfonic Acid (MSA 70%) is involved in the synthesis of specialty solvents, where its stability and non-volatility are advantageous.
In the pharmaceutical industry, MSA is used for the synthesis of drug intermediates, showcasing its significance in drug development.

Methane Sulfonic Acid (MSA 70%) finds application in the synthesis of agrochemicals, contributing to the production of pesticides and herbicides.
Methane Sulfonic Acid (MSA 70%) is employed in the manufacturing of electrochemical cells and batteries as an electrolyte additive.

Methane Sulfonic Acid (MSA 70%) plays a role in the production of dyes and pigments, contributing to the coloration of various materials.
In the field of analytical chemistry, MSA is used for sample preparation and derivatization of compounds for analysis.
Methane Sulfonic Acid (MSA 70%) is utilized in the synthesis of flavors and fragrances, contributing to the creation of unique aromatic compounds.
Methane Sulfonic Acid (MSA 70%) is involved in the formulation of photoresists used in semiconductor manufacturing for photolithography processes.

Methane Sulfonic Acid (MSA 70%) serves as an acid-catalyst in the production of biodiesel, aiding in the transesterification of triglycerides.
In the synthesis of specialty chemicals, MSA enhances the efficiency of certain chemical reactions, leading to improved yields.
Methane Sulfonic Acid (MSA 70%) is used in the production of adhesives and sealants, contributing to the formulation of bonding agents.

Methane Sulfonic Acid (MSA 70%) finds application in the synthesis of fine organic chemicals used in the production of high-performance materials.
Methane Sulfonic Acid (MSA 70%) is employed in the development of coatings and surface treatments, enhancing the adhesion of coatings to substrates.

Methane Sulfonic Acid (MSA 70%) is used in analytical laboratories for pH adjustment and sample preparation due to its stability.
In the field of biotechnology, Methane Sulfonic Acid (MSA 70%) is employed in certain enzymatic reactions to enhance reaction rates and specificity.
Methane Sulfonic Acid (MSA 70%)'s versatility in catalysis and chemical synthesis contributes to its widespread applications in research, development, and industrial processes.

Methane Sulfonic Acid (MSA 70%) is utilized in the production of specialty polymers, acting as a catalyst in the synthesis of unique polymer structures.
Methane Sulfonic Acid (MSA 70%) plays a crucial role in the production of electronic components, being employed in the etching of printed circuit boards.
Methane Sulfonic Acid (MSA 70%) is used in the synthesis of pharmaceutical intermediates, contributing to the development of therapeutic compounds.
In the field of surface modification, MSA finds application in the treatment of materials to enhance their adhesion properties.

Methane Sulfonic Acid (MSA 70%) is involved in the production of metal-complex dyes, contributing to the vibrant coloration of textiles and other materials.
Methane Sulfonic Acid (MSA 70%) is utilized in the preparation of chemical intermediates for the manufacturing of agrochemicals and insecticides.
Methane Sulfonic Acid (MSA 70%) serves as an acid catalyst in the synthesis of plasticizers, aiding in the modification of polymer properties.

Methane Sulfonic Acid (MSA 70%) is employed in the production of fuel cells, contributing to the enhancement of fuel cell performance.
In the synthesis of specialty solvents, MSA acts as a key reagent, providing stable and effective reaction conditions.

Methane Sulfonic Acid (MSA 70%) is used in the synthesis of photoactive materials for photovoltaic applications.
Methane Sulfonic Acid (MSA 70%) finds application in the formulation of electrolytes for supercapacitors, enhancing energy storage capabilities.
Methane Sulfonic Acid (MSA 70%) is involved in the manufacturing of coatings for electrodes in electrochemical devices, contributing to their efficiency.
Methane Sulfonic Acid (MSA 70%) is used in the purification of proteins and peptides in biotechnological processes.

Methane Sulfonic Acid (MSA 70%) serves as a catalyst in the esterification of fatty acids, contributing to the production of biodiesel.
Methane Sulfonic Acid (MSA 70%) is employed in the production of specialty chemicals used in the mining industry for mineral processing.

Methane Sulfonic Acid (MSA 70%) is utilized in the formulation of adhesives for bonding a variety of materials, including plastics and metals.
In the field of analytical chemistry, MSA is used for derivatization reactions to improve the detectability of certain compounds.
Methane Sulfonic Acid (MSA 70%) finds application in the synthesis of antioxidants, contributing to the stabilization of materials against oxidative degradation.

Methane Sulfonic Acid (MSA 70%) is used in the preparation of chemical reagents for nucleic acid synthesis in molecular biology.
Methane Sulfonic Acid (MSA 70%) plays a role in the production of plastic additives, enhancing the performance and durability of plastic materials.
Methane Sulfonic Acid (MSA 70%) is employed in the synthesis of flavor enhancers and fragrances for the food and cosmetic industries.

Methane Sulfonic Acid (MSA 70%) finds application in the treatment of industrial effluents, contributing to the removal of heavy metals.
Methane Sulfonic Acid (MSA 70%) is used in the formulation of electrolytes for lithium-ion batteries, influencing their electrochemical performance.

Methane Sulfonic Acid (MSA 70%) serves as a valuable reagent in the synthesis of fine chemicals for various industrial applications.
Methane Sulfonic Acid (MSA 70%) is involved in the production of inkjet inks, contributing to the stability and performance of the ink formulations.

Methane Sulfonic Acid (MSA 70%) is utilized in the synthesis of specialty detergents and cleaning agents, enhancing their effectiveness in removing contaminants.
Methane Sulfonic Acid (MSA 70%) plays a role in the formulation of corrosion inhibitors for protecting metal surfaces in various industrial processes.

Methane Sulfonic Acid (MSA 70%) is employed in the production of specialty paints and coatings, contributing to improved adhesion and durability.
In the field of electrochemistry, MSA is used in the preparation of electrolytes for redox flow batteries.
Methane Sulfonic Acid (MSA 70%) is involved in the synthesis of ion exchange resins, which find applications in water treatment processes.
Methane Sulfonic Acid (MSA 70%) is used in the production of specialty adhesives for bonding materials in challenging environments.

Methane Sulfonic Acid (MSA 70%) serves as a key component in the formulation of liquid crystal materials used in the electronics and display industries.
Methane Sulfonic Acid (MSA 70%) is employed in the synthesis of specialty monomers for the production of high-performance polymers.
In the field of catalysis, MSA plays a role in asymmetric transformations, enabling the synthesis of chiral compounds.

Methane Sulfonic Acid (MSA 70%) is utilized in the manufacturing of specialty lubricants, contributing to improved performance in various applications.
Methane Sulfonic Acid (MSA 70%) finds application in the synthesis of photoactive materials for photonic devices and sensors.
Methane Sulfonic Acid (MSA 70%) is involved in the production of specialty waxes used in formulations such as polishes and coatings.

Methane Sulfonic Acid (MSA 70%) is employed in the preparation of chemical intermediates for the synthesis of pharmaceuticals and agrochemicals.
Methane Sulfonic Acid (MSA 70%) serves as a reagent in the synthesis of surfactants, contributing to their emulsifying and dispersing properties.
Methane Sulfonic Acid (MSA 70%) is used in the synthesis of specialty resins for the production of high-quality inks and coatings.

In the field of analytical chemistry, MSA is employed for sample preparation and derivatization in chromatographic techniques.
Methane Sulfonic Acid (MSA 70%) finds application in the production of specialty inorganic salts, utilized in various industrial processes.
Methane Sulfonic Acid (MSA 70%) is utilized in the synthesis of specialty plastic materials, enhancing their thermal and mechanical properties.
Methane Sulfonic Acid (MSA 70%) is involved in the formulation of electrolytes for electrochemical capacitors, contributing to their energy storage capabilities.

Methane Sulfonic Acid (MSA 70%) is used in the preparation of metal-organic frameworks (MOFs), which have applications in gas storage and separation.
Methane Sulfonic Acid (MSA 70%) plays a role in the synthesis of specialty polymers with controlled molecular weights and architectures.

Methane Sulfonic Acid (MSA 70%) is employed in the production of corrosion-resistant coatings for metal surfaces in harsh environments.
Methane Sulfonic Acid (MSA 70%) serves as a catalyst in the production of biodiesel from triglycerides, facilitating transesterification reactions.
Methane Sulfonic Acid (MSA 70%) is used in the formulation of heat transfer fluids, contributing to efficient heat exchange in various industrial processes.
In the field of nanotechnology, MSA is involved in the synthesis of nanomaterials with tailored properties for diverse applications.



DESCRIPTION


Methane Sulfonic Acid (MSA 70%) is a strong organic acid with the chemical formula CH3SO3H.
Methane Sulfonic Acid (MSA 70%) is a colorless liquid and is miscible with water and many organic solvents.
Methane Sulfonic Acid (MSA 70%) is often encountered in its solution form, and the term "MSA 70%" refers to a solution where the MSA is present at a concentration of 70%.

Methane Sulfonic Acid (MSA 70%) is a clear, colorless liquid with a faint odor.
As a strong organic acid, MSA is known for its stability and non-volatile nature.
Methane Sulfonic Acid (MSA 70%) is miscible with water and various organic solvents, enhancing its versatility.
Methane Sulfonic Acid (MSA 70%) is often encountered in solution form, and the 70% concentration indicates a common commercial formulation.

The chemical structure of MSA includes a methyl group and a sulfonic acid group.
With the chemical formula CH3SO3H, MSA is a valuable reagent in various chemical processes.
Methane Sulfonic Acid (MSA 70%) is recognized for its utility as a catalyst in organic synthesis, facilitating numerous reactions.
Its lack of volatility compared to other strong acids makes MSA a preferred choice in certain industrial applications.

Methane Sulfonic Acid (MSA 70%) is used in esterification reactions as an efficient acid catalyst.
Methane Sulfonic Acid (MSA 70%)'s stability under different conditions contributes to its popularity in laboratory and industrial settings.
The solution form of MSA often contains water or another solvent, influencing its properties and applications.
In addition to catalysis, MSA finds use as a solvent in organic synthesis, enhancing reaction efficiency.

Methane Sulfonic Acid (MSA 70%) is known by various synonyms, including Methanesulfonic acid and Methylsulfonic acid.
Methane Sulfonic Acid (MSA 70%) is essential in certain reactions where a non-volatile and stable acid is required.
Its compatibility with a range of materials makes it suitable for various manufacturing processes.
The 70% solution is a commonly used concentration, balancing reactivity and ease of handling.
Methane Sulfonic Acid (MSA 70%)'s chemical stability extends to its resistance to decomposition under normal storage conditions.

Due to its strong acidity, MSA is handled with appropriate precautions and protective equipment.
Methane Sulfonic Acid (MSA 70%)'s lack of flammability makes it a safe choice in laboratory and industrial environments.
Methane Sulfonic Acid (MSA 70%)'s efficacy as a catalyst contributes to its role in accelerating chemical transformations.
Its non-corrosive nature towards common metals enhances its applicability in different processes.

Methane Sulfonic Acid (MSA 70%)'s versatility is highlighted by its use in various sectors, including pharmaceuticals and specialty chemicals.
Methane Sulfonic Acid (MSA 70%)'s water miscibility ensures uniform distribution in aqueous systems during reactions.
As a stable and efficient acid, MSA continues to play a crucial role in advancing chemical synthesis methodologies.
Methane Sulfonic Acid (MSA 70%)'s widespread use underscores its importance in both academic research and industrial applications.



PROPERTIES


Chemical Formula: CH3SO3H
Molecular Weight: Approximately 96.10 g/mol
Physical Form: Clear, colorless liquid
Odor: Faint odor
Melting Point: Approximately -30 °C (-22 °F)
Boiling Point: Approximately 167 °C (333 °F) at atmospheric pressure
Density: Approximately 1.48 g/cm³ at 20 °C (68 °F)
Solubility in Water: Miscible in water
Vapor Pressure: Negligible at ambient temperatures
pH: Highly acidic in aqueous solutions
Viscosity: Low viscosity liquid
Refractive Index: Typically around 1.38
Flash Point: Non-flammable
Autoignition Temperature: Not applicable as it is non-flammable
Stability: Stable under normal storage conditions
Hygroscopicity: Exhibits hygroscopic behavior, absorbing moisture from the air
Corrosivity: Can be corrosive to certain metals and materials
Compatibility: Compatible with various organic solvents
Miscibility: Miscible with a wide range of organic solvents
Acidity: Strong acid with a dissociation constant (pKa) around -1.9
Hazardous Polymerization: Will not occur
Flammability: Non-flammable
Toxicity: Generally low toxicity, but appropriate precautions should be taken



FIRST AID


Inhalation:

If inhalation of MSA vapors occurs, immediately move the affected person to an area with fresh air.
If respiratory distress persists, seek medical attention promptly.
Provide artificial respiration if the person is not breathing, and administer oxygen by trained personnel if necessary.


Skin Contact:

In case of skin contact, promptly remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes.
Use mild soap if available and continue rinsing.
Seek medical attention if irritation or chemical burns develop.
Wash contaminated clothing thoroughly before reuse.


Eye Contact:

If MSA comes into contact with the eyes, immediately flush the eyes with gently flowing water for at least 15 minutes, holding the eyelids open.
Seek immediate medical attention, even if irritation is minimal.
Remove contact lenses, if applicable, after the initial eye rinse.


Ingestion:

If MSA is ingested accidentally, rinse the mouth with water.
Do not induce vomiting unless instructed to do so by medical professionals.
Seek immediate medical attention and provide the healthcare provider with information about the ingested substance.


General First Aid Measures:

If any adverse reactions, such as skin irritation or respiratory discomfort, occur after exposure to MSA, seek medical assistance promptly.
If seeking medical attention, provide healthcare professionals with details about the specific MSA product and the nature of exposure.
Be prepared to provide information on the concentration and form of MSA involved in the exposure.
If available, have the safety data sheet (SDS) or product information accessible for medical professionals.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles or face shield, and protective clothing, to minimize skin and eye contact.
Use respiratory protection if handling in conditions where vapors or mists may be generated.

Ventilation:
Work in a well-ventilated area or use local exhaust ventilation to control airborne concentrations.
If handling in an enclosed space, ensure proper ventilation systems are in place to minimize inhalation risks.

Avoidance of Contact:
Avoid direct skin and eye contact with MSA.
Take precautions to prevent inhalation of vapors, mists, or dust.
Minimize exposure through the use of engineering controls and PPE.

Handling Procedures:
Follow good laboratory or industrial practices when working with MSA.
Use appropriate tools and equipment to minimize the generation of dust or aerosols during handling.

Spill Response:
In case of a spill, use suitable absorbent materials to contain and clean up the spilled substance.
Dispose of waste according to local regulations and in accordance with the product's safety data sheet (SDS).

Storage Compatibility:
Store MSA away from incompatible materials, such as strong bases, reducing agents, and reactive metals.
Check compatibility with storage containers to prevent chemical reactions.

Labeling:
Ensure containers are properly labeled with the correct product information, hazard symbols, and safety precautions.
Maintain clear and visible labeling on secondary containers in case of transfer.


Storage:

Temperature:
Store MSA in a cool, well-ventilated area, away from heat sources and direct sunlight.
Avoid exposure to extreme temperatures, as excessive heat may affect the stability of the substance.

Container Integrity:
Ensure that storage containers are tightly sealed to prevent contamination or evaporation.
Regularly inspect containers for any signs of damage or leaks.

Ventilation During Storage:
If stored in an enclosed area, provide adequate ventilation to prevent the accumulation of vapors.

Storage Conditions:
Store MSA in accordance with the manufacturer's recommendations.
Keep the substance away from incompatible materials and follow guidelines for the storage of corrosive substances.

Separation from Food and Feed:
Store MSA away from food, beverages, and animal feed.
Use separate storage areas to avoid cross-contamination.

Handling Precautions:
Follow proper handling procedures when transferring MSA between containers or dispensing it for use.
Minimize the risk of spills during storage and handling.

Fire Prevention:
MSA is generally non-flammable, but it is advisable to keep it away from open flames, sparks, or potential ignition sources.
Store in areas compliant with fire safety regulations.

Emergency Response:
Have appropriate emergency response equipment, such as spill containment materials and fire extinguishers, readily available.

METHANE SULFONIC ACID (MSA 70%)
Methane Sulfonic Acid (MSA 70%) is an alkanesulfonic acid and a one-carbon compound.
Methane Sulfonic Acid (MSA 70%) is a conjugate acid of a methanesulfonate.
Methane Sulfonic Acid (MSA 70%) is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.

CAS Number: 75-75-2
Molecular Formula: CH4O3S
Molecular Weight: 96.11
EINECS Number: 200-898-6

Methane Sulfonic Acid (MSA 70%) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities.
Methane Sulfonic Acid (MSA 70%) undergoes biodegradation by forming CO2 and sulphate.

Methane Sulfonic Acid (MSA 70%) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methane Sulfonic Acid (MSA 70%) solution has been considered a model electrolyte for electrochemical processes.

Methane Sulfonic Acid (MSA 70%) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane Sulfonic Acid (MSA 70%) has a role as an Escherichia coli metabolite.
Methanesulfonic acid (MsOH) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH.

Methane Sulfonic Acid (MSA 70%) is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).
Salts and esters of Methane Sulfonic Acid (MSA 70%) are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).
Methane Sulfonic Acid (MSA 70%) is hygroscopic in its concentrated form.

Methane Sulfonic Acid (MSA 70%) can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).
Methane Sulfonic Acid (MSA 70%) solution is used virtually in all electronic applications involving tin or tin-alloy plating from non fluoborate systems.
Methane Sulfonic Acid (MSA 70%) replaces phosphoric acid in detergent formulations, thereby helping to avoid environmental phosphate pollution.

Methane Sulfonic Acid (MSA 70%) is used in the preparation of polyaniline/graphene nanocomposites, which enhances its thermal and electrical properties.
Methane Sulfonic Acid (MSA 70%) is utilized for electropolishing of aluminum as well as in electroplating of noble metals like gold, platinum, palladium and their alloys.
Methane Sulfonic Acid (MSA 70%) is considered a particularly suitable supporting electrolyte for electrochemical applications, where it stands as an environmentally friendly alternative to other acid electrolytes used in plating processes.

Methane Sulfonic Acid (MSA 70%) is also a primary ingredient in rust remover and descaler.
Methane Sulfonic Acid (MSA 70%) is recommended in formulation for removing rust from ceramic, tiles and porcelain surfaces which are usually susceptible to acid attack.
Methane Sulfonic Acid (MSA 70%) or methanesulfonic acid (British English) is an organic sulfuric acid colorless liquid with the molecular formula CH3SO3H and the structure H3C-S(=O)2-OH.

Methane Sulfonic Acid (MSA 70%), the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.
Methane Sulfonic Acid (MSA 70%) has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa), the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃).
Methane Sulfonic Acid (MSA 70%) is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene.

Methane Sulfonic Acid (MSA 70%) will not subject to decomposition in boiling water and hot alkaline solution.
Methane Sulfonic Acid (MSA 70%) also has strong corrosion effect against the metal iron, copper and lead.
Methane Sulfonic Acid (MSA 70%) is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.

Methane Sulfonic Acid (MSA 70%) is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, Methane Sulfonic Acid (MSA 70%) is used as a starting material for the preparation of methanesulfonyl chloride.
Methane Sulfonic Acid (MSA 70%) is a strong organic acid widely used as a catalyst for esterification and alkylation.

Strong acid, biodegradable, non-oxidizing and non-foaming, compatible with oxidant and biocide.
Methane Sulfonic Acid (MSA 70%), also known as methylsulfonic acid or methane sulfonate, is a strong organic acid with the chemical formula CH3SO3H.
Methane Sulfonic Acid (MSA 70%) is a colorless, odorless liquid that is highly soluble in water.

Methane Sulfonic Acid (MSA 70%) is classified as a sulfonic acid because it has a sulfonyl (SO3H) functional group attached to a methyl (CH3) group.
Methane Sulfonic Acid (MSA 70%) is often used as a substitute for sulfuric acid (H2SO4) in various chemical processes because it is less corrosive and volatile.
Methane Sulfonic Acid (MSA 70%) is commonly employed as a catalyst, acidifier, or pH adjuster in organic synthesis, electroplating, and other industrial applications.

Methane Sulfonic Acid (MSA 70%) mild and non-oxidizing nature makes it useful in situations where strong acids like sulfuric acid may be too harsh.
Methane Sulfonic Acid (MSA 70%) refers to the concentration of MSA in a solution.

In this case, Methane Sulfonic Acid (MSA 70%) means that the solution contains 70% by weight of pure MSA, with the remaining 30% typically being water.
Different concentrations of Methane Sulfonic Acid (MSA 70%) can be prepared depending on the specific application's requirements.

Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
vapor density: 3.3 (vs air)
vapor pressure: 1 mm Hg ( 20 °C)
refractive index: n20/D 1.429(lit.)
Flash point: >230 °F
storage temp.: 2-8°C
solubility: water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
form: Solution
color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible: with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024

Methane Sulfonic Acid (MSA 70%) is a strong, odorless and less corrosive acid.
Methane Sulfonic Acid (MSA 70%) is not harmful to systems, employees, customers, waste management or the environment when used in chemical synthesis, metal refinement or industrial cleaning.
Methane Sulfonic Acid (MSA 70%) can be used sparingly and saves energy.

Additional advantages are the high solubility of Methane Sulfonic Acid (MSA 70%)s salts, its lack of color and the fact that it is readily biodegradable (according to OECD Directive 301 A).
The acid strength of the organic methane sulphonic acid is between that of carboxylic acids and strong mineral acids.
Since methane sulphonic acid is odorless, Methane Sulfonic Acid (MSA 70%) may also be used in odor-sensitive applications.

Methane Sulfonic Acid (MSA 70%)s lack of smell also increases safety at work because it does not produce any acrid fumes.
Methane Sulfonic Acid (MSA 70%) is very suitable for neutralisation of vegetable oils with high FFA content.
Methane Sulfonic Acid (MSA 70%) is a strong acid with a pKa (acid dissociation constant) of about -1.9, making it significantly more acidic than acetic acid (vinegar) or many other common organic acids.

Methane Sulfonic Acid (MSA 70%) is highly soluble in water, which makes it suitable for various aqueous processes and reactions.
Methane Sulfonic Acid (MSA 70%) should be stored in a cool, dry place away from incompatible materials.
Methane Sulfonic Acid (MSA 70%) should be kept in containers made of materials resistant to acids, such as glass or certain plastics.

Methane Sulfonic Acid (MSA 70%) is often used as a milder and safer alternative to mineral acids like sulfuric acid (H2SO4) and hydrochloric acid (HCl) in laboratory settings and industrial processes.
Its reduced corrosiveness and lower volatility make it a preferred choice in situations where worker safety and equipment preservation are essential.
Methane Sulfonic Acid (MSA 70%) is compatible with a wide range of organic compounds, which makes it useful in various organic syntheses and reactions.

Methane Sulfonic Acid (MSA 70%) can serve as a solvent, acid catalyst, or reagent in reactions involving a variety of functional groups.
Like other acids, Methane Sulfonic Acid (MSA 70%) can be neutralized with bases such as sodium hydroxide (NaOH) or potassium hydroxide (KOH) to form salts, for instance, sodium methane sulfonate or potassium methane sulfonate.

In the pharmaceutical industry, Methane Sulfonic Acid (MSA 70%) is used in the production of certain pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
Its high purity and low residue levels are advantageous in drug manufacturing.
Methane Sulfonic Acid (MSA 70%) can be used in analytical chemistry techniques such as ion chromatography, where it serves as a highly stable and inert mobile phase component for separating ions in solution.

Methane Sulfonic Acid (MSA 70%) is less likely to corrode or react with metals, which is advantageous when it is used in metal-related applications like electroplating.
Methane Sulfonic Acid (MSA 70%) is generally recognized as safe (GRAS) when used in food and pharmaceutical applications within established guidelines.

Methane Sulfonic Acid (MSA 70%) is essential to ensure compliance with local regulations and quality standards when using MSA in various industries.
Methane Sulfonic Acid (MSA 70%), it is important to follow the appropriate regulations for hazardous materials, including labeling, packaging, and safety precautions, to prevent accidents and ensure worker safety.

Production method:
Methane Sulfonic Acid (MSA 70%) can be obtained through the nitrate oxidation of thiocyanate methyl.
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃.

After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product.
The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered.
The filtrate is condensed to until crystalline precipitation.

The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate.
It is then added to the exchanged water to boiling, add sulfuric acid for decomposition while it is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product.

Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction.
The reaction solution was extracted with chloroform.

After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure.
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride.

Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear.
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain methanesulfonic acid.

Uses
Methane Sulfonic Acid (MSA 70%) is a raw material for medicine and pesticide.
Methane Sulfonic Acid (MSA 70%) can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
Methane Sulfonic Acid (MSA 70%) can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry.

Methane Sulfonic Acid (MSA 70%) can also be applied to oxidation.
Methane Sulfonic Acid (MSA 70%) has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings.
One of the major advantages of Methane Sulfonic Acid (MSA 70%) over sulfuric acid is that it is not an oxidizing species.

Methane Sulfonic Acid (MSA 70%) solution is used virtually in all electronic applications involving tin or tin-alloy plating from non fluoborate systems.
Methane Sulfonic Acid (MSA 70%) replaces phosphoric acid in detergent formulations, thereby helping to avoid environmental phosphate pollution.
Methane Sulfonic Acid (MSA 70%) is used in the preparation of polyaniline/graphene nanocomposites, which enhances its thermal and electrical properties.

Methane Sulfonic Acid (MSA 70%) is utilized for electropolishing of aluminum as well as in electroplating of noble metals like gold, platinum, palladium and their alloys.
Methane Sulfonic Acid (MSA 70%) is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents.

Methane Sulfonic Acid (MSA 70%) is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters.
Methane Sulfonic Acid (MSA 70%) reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex.
It finds application in batteries, because of its purity and chloride absence.

In pharmaceutical industry, Methane Sulfonic Acid (MSA 70%) is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan.
Methane Sulfonic Acid (MSA 70%) is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
Methane Sulfonic Acid (MSA 70%) is involved in the deprotection of peptides.

Methane Sulfonic Acid (MSA 70%) is used as a catalyst in a variety of organic reactions, including esterification, etherification, and alkylation reactions.
Methane Sulfonic Acid (MSA 70%) is employed in the electroplating industry to improve the quality of metal coatings.
Methane Sulfonic Acid (MSA 70%) is used in the synthesis of pharmaceuticals and fine chemicals.

Methane Sulfonic Acid (MSA 70%)'s used for dyeing textiles and leather.
Methane Sulfonic Acid (MSA 70%) can be used in the oil and gas industry for acidizing reservoirs.
Methane Sulfonic Acid (MSA 70%) is a versatile acid catalyst in various organic reactions, such as esterification, etherification, and alkylation.

Methane Sulfonic Acid (MSA 70%) facilitates chemical reactions by donating protons (H+) to reactants, enabling the formation of new bonds and the synthesis of desired compounds.
Methane Sulfonic Acid (MSA 70%) is used in the electroplating industry to improve the quality of metal coatings.
Methane Sulfonic Acid (MSA 70%) can be employed as an additive in electroplating baths to enhance the deposition of metal layers onto surfaces, providing improved adhesion and uniformity.

Methane Sulfonic Acid (MSA 70%) finds application in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
Its high purity and low residue levels are advantageous in drug manufacturing processes where the presence of impurities can be detrimental.

Methane Sulfonic Acid (MSA 70%) is utilized in the dyeing of textiles and leather.
Methane Sulfonic Acid (MSA 70%) serves as a strong acid to help fix dyes onto fabric or leather surfaces, enhancing colorfastness and dye adherence.
In the oil and gas industry, Methane Sulfonic Acid (MSA 70%) can be used for acidizing reservoirs.

Methane Sulfonic Acid (MSA 70%) helps improve the permeability of rock formations in oil and gas wells by dissolving mineral deposits and increasing the flow of hydrocarbons.
Methane Sulfonic Acid (MSA 70%) is used as a component of mobile phases in ion chromatography, a technique employed for separating and analyzing ions in solution.
Its stability and low reactivity make it suitable for this purpose.

Methane Sulfonic Acid (MSA 70%) is often used in research laboratories as a milder alternative to stronger mineral acids like sulfuric acid or hydrochloric acid.
Methane Sulfonic Acid (MSA 70%) can be employed for tasks such as acid-catalyzed reactions or pH adjustments in various experiments.
Methane Sulfonic Acid (MSA 70%) is sometimes used as a pH adjuster and acidulant in certain food products.

Methane Sulfonic Acid (MSA 70%)s use is regulated to ensure food safety and quality.
Methane Sulfonic Acid (MSA 70%) has been used in photography, particularly in the preparation of photographic developers.
Methane Sulfonic Acid (MSA 70%) can be found in some cleaning products where its acidity helps in removing mineral deposits, scale, and stains.

Methane Sulfonic Acid (MSA 70%) is employed in polymerization reactions, including the production of certain types of resins, plastics, and polymeric materials.
Its acidic nature can initiate and control polymerization processes.
Methane Sulfonic Acid (MSA 70%) is useful for synthesizing various organic compounds, including fragrances, flavors, and specialty chemicals.

Methane Sulfonic Acid (MSA 70%) can be involved in reactions that create valuable intermediates for these industries.
Methane Sulfonic Acid (MSA 70%) can be used for descaling and removing oxide layers from metal surfaces, preparing them for subsequent treatments or coatings.
Methane Sulfonic Acid (MSA 70%) can be used for pH adjustment and water treatment processes, particularly in situations where a strong acid is needed to neutralize alkaline water or control the pH of industrial wastewater.

Methane Sulfonic Acid (MSA 70%) finds use in electronics manufacturing for cleaning and etching printed circuit boards (PCBs) and other electronic components.
Methane Sulfonic Acid (MSA 70%) can be used in the production of adhesives and sealants, where it can act as a curing agent or catalyst.
In the oil refining industry, Methane Sulfonic Acid (MSA 70%) can be used as a catalyst or acid in certain refining processes to improve the quality of petroleum products.

Methane Sulfonic Acid (MSA 70%) is used as a reagent in various chemical analyses and assays, especially when a strong acid is required for sample preparation or digestion.
Methane Sulfonic Acid (MSA 70%) is sometimes used for pH adjustment in industrial processes where precise control of acidity is necessary.
Methane Sulfonic Acid (MSA 70%) can be used in biotechnology and molecular biology applications, such as DNA and RNA purification and protein purification processes.

Safety Profile:
Poison by ingestion and intraperitoneal routes.
Methane Sulfonic Acid (MSA 70%) may be corrosive to skin, eyes, and mucous membranes.
Explosive reaction with ethyl vinyl ether.

Incompatible with hydrogen fluoride.
When heated to decomposition Methane Sulfonic Acid (MSA 70%) emits toxic fumes of SOx.

While Methane Sulfonic Acid (MSA 70%) is considered less hazardous than some other strong acids like sulfuric acid, it is still corrosive and should be handled with care.
Proper safety measures, including the use of appropriate protective gear like gloves and goggles, should be followed when working with Methane Sulfonic Acid (MSA 70%).

Environmental Considerations:
Methane Sulfonic Acid (MSA 70%) is considered to be less environmentally harmful than many other strong acids, especially when it comes to disposal.
Methane Sulfonic Acid (MSA 70%) is less likely to produce environmentally damaging byproducts when handled and disposed of properly.

Synonyms
METHANESULFONIC ACID
75-75-2
Methylsulfonic acid
Methanesulphonic acid
Mesylic acid
Methanesulfonicacid
Sulfomethane
Kyselina methansulfonova
Methansulfonsaeure
NSC 3718
CCRIS 2783
HSDB 5004
EINECS 200-898-6
METHANE SULFONIC ACID
BRN 1446024
DTXSID4026422
MSA
UNII-12EH9M7279
CHEBI:27376
Kyselina methansulfonova [Czech]
AI3-28532
NSC-3718
CH3SO3H
MFCD00007518
CH4O3S
12EH9M7279
DTXCID806422
22515-76-0
NSC3718
EC 200-898-6
4-04-00-00010 (Beilstein Handbook Reference)
J1.465F
ammoniummethanesulfonate
METHANESULFONIC ACID (II)
METHANESULFONIC ACID [II]
CH4O3S.H3N
C-H4-O3-S.H3-N
Methanesulfonic acid, ammonium salt
Methanesulfonic acid, ammonium salt (1:1)
metanesulfonic acid
methansulfonic acid
MsOH
methansulphonic acid
methylsulphonic acid
03S
methyl sulfonic acid
methyl-sulfonic acid
methane-sulfonic acid
MeSO3H
methane sulphonic acid
methanesulphonic-acid-
LACTIC ACID(DL)
CH3SO2OH
H3CSO3H
WLN: WSQ1
Methanesulfonic acid solution
Methanesulfonic acid, 99.5%
Methanesulfonic acid, anhydrous
CHEMBL3039600
DL-MALICACIDMONOSODIUMSALT
Methanesulfonic Acid (CH3SO3H)
METHANESULFONIC ACID [MI]
Methanesulfonic acid, HPLC grade
Methanesulfonic acid, >=99.0%
METHANESULFONIC ACID [HSDB]
Tox21_201073
STL264182
AKOS009146947
AT25153
CAS-75-75-2
NCGC00248914-01
NCGC00258626-01
BP-12823
LS-90299
FT-0628287
M0093
M2059
EN300-29198
Methanesulfonic acid, >=99.0%, ReagentPlus(R)
Methanesulfonic acid, for HPLC, >=99.5% (T)
A934985
Q414168
J-521696
Methanesulfonic acid, Vetec(TM) reagent grade, 98%
F1908-0093
Z281776238
InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4
METHANE SULFONIC ACID (MSA)
Methane Sulfonic Acid (MSA) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane Sulfonic Acid (MSA) has a role as an Escherichia coli metabolite.
Methane Sulfonic Acid (MSA) is an alkanesulfonic acid and a one-carbon compound.


CAS Number: 75-75-2
EC Number: 200-898-6
MDL number: MFCD00007518
Linear Formula: CH3SO3H
Chemical formula: CH4O3S



SYNONYMS:
Methanesulfonic acid, Methylsulfonic acid, MSA; Mesylic acid, Mesylic acid, MsOH, METHANESULFONIC ACID, 75-75-2, Methylsulfonic acid, Methanesulphonic acid, Mesylic acid, Methanesulfonicacid, Sulfomethane, Kyselina methansulfonova, Methansulfonsaeure, NSC 3718, CCRIS 2783, HSDB 5004, EINECS 200-898-6, METHANE SULFONIC ACID, MsOH, BRN 1446024, DTXSID4026422, MSA, UNII-12EH9M7279, CHEBI:27376, AI3-28532, NSC-3718, CH3SO3H, MFCD00007518, 12EH9M7279, DTXCID806422, NSC3718, EC 200-898-6, 4-04-00-00010 (Beilstein Handbook Reference), J1.465F, ammoniummethanesulfonate, METHANESULFONIC ACID (II), METHANESULFONIC ACID [II], Kyselina methansulfonova [Czech], CH4O3S, metanesulfonic acid, methansulfonic acid, methansulphonic acid, methylsulphonic acid, 03S, methyl sulfonic acid, methyl-sulfonic acid, methane-sulfonic acid, MeSO3H, methane sulphonic acid, methanesulphonic-acid-, LACTIC ACID(DL), CH3SO2OH, H3CSO3H, WLN: WSQ1, Methanesulfonic acid solution, Methanesulfonic acid, 99.5%, Methanesulfonic acid, anhydrous, CHEMBL3039600, DL-MALICACIDMONOSODIUMSALT, Methanesulfonic Acid (CH3SO3H), METHANESULFONIC ACID [MI], Methanesulfonic acid, HPLC grade, Methanesulfonic acid, >=99.0%, METHANESULFONIC ACID [HSDB], Tox21_201073, AKOS009146947, AT25153, CAS-75-75-2, NCGC00248914-01, NCGC00258626-01, BP-12823, M0093, M2059, NS00004472, EN300-29198, Methanesulfonic acid, >=99.0%, ReagentPlus(R), Methanesulfonic acid, for HPLC, >=99.5% (T), A934985, Q414168, J-521696, Methanesulfonic acid, Vetec(TM) reagent grade, 98%, F1908-0093, Z281776238, InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4), methylsulfonic acid, methanesulphonic acid, methanesulfonicacid, ch3so3h, methane sulfonic acid, sulfomethane, Methanesulphonic acid, Methylsulfonic acid, Kyselina methansulfonova, CH3SO3H, NSC 371, MsOH, MSA, MeSO3H, METHANESULPHONIC ACID, METHYLSULFONIC ACID, acidemethanesulfonique, METHANE SULFONIC ACID 70%, Mesic acid, SULFOMETHANE, Methylsulphonicacid



Pharmaceutical-Grade Methane Sulfonic Acid (MSA) is a superior-quality chemical compound with the formula CH3SO3H.
Its superior solubility properties make Methane Sulfonic Acid (MSA) suitable for diverse applications.
Excellent Properties of Methane Sulfonic Acid (MSA): Features high purity, strong acidity, broad solubility, and storage stability.


Since ca. 2000 Methane Sulfonic Acid (MSA) has become a popular replacement for other acids in numerous industrial and laboratory applications.
Methane Sulfonic Acid (MSA) is a strong acid.
Methane Sulfonic Acid (MSA) has a low vapor pressure (see boiling points in the "Properties" inset).


Methane Sulfonic Acid (MSA) is not an oxidant or explosive, like nitric, sulfuric or perchloric acids.
Methane Sulfonic Acid (MSA) is a liquid at room temperature.
Methane Sulfonic Acid (MSA) is soluble in many organic solvents.


Methane Sulfonic Acid (MSA) forms water-soluble salts with all inorganic cations and with most organic cations.
Methane Sulfonic Acid (MSA) does not form complexes with metal ions in water.
Its anion, mesylate, and Methane Sulfonic Acid (MSA) is non-toxic and suitable for pharmaceutical preparations.


The closely related p-toluenesulfonic acid (PTSA) is solid.
Methane Sulfonic Acid (MSA) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane Sulfonic Acid (MSA) has a role as an Escherichia coli metabolite.


Methane Sulfonic Acid (MSA) is an alkanesulfonic acid and a one-carbon compound.
Methane Sulfonic Acid (MSA) is a conjugate acid of a methanesulfonate.
Methane Sulfonic Acid (MSA) is a strong organic acid which is highly suitable for manufacturing active pharmaceutical ingredients such as Telmisartan and Eprosartan, Angiotensin II receptor antagonists.


Methane Sulfonic Acid (MSA) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH.
Methane Sulfonic Acid (MSA) is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).
Salts and esters of Methane Sulfonic Acid (MSA) are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).


Methane Sulfonic Acid (MSA) is hygroscopic in its concentrated form.
Methane Sulfonic Acid (MSA) can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).


Methane Sulfonic Acid (MSA), the simplest alkanesulfonic acid, is a hygroscopic colorless liquid or white solid, depending on whether the ambient temperature is greater or less than 20 ºC.
Methane Sulfonic Acid (MSA) is very soluble in water and oxygenated solvents, but sparingly soluble in most hydrocarbons.


In aqueous solution, Methane Sulfonic Acid (MSA) is a strong acid (completely ionized).
Methane Sulfonic Acid (MSA)’s acidity and solubility properties make it industrially valuable as a catalyst in organic reactions, particularly polymerization.


In many applications, its advantage over concentrated sulfuric acid is that Methane Sulfonic Acid (MSA) has similar acid strength but is not an oxidant.
The first report of Methane Sulfonic Acid (MSA) synthesis was in a 1950 patent awarded to John C. Snyder and Aristid V. Grosse of Houdry Process Corp. (subsequently acquired by Air Products).


They heated methane and sulfur trioxide to 200–325 ºC under pressure in the presence of a mercury catalyst.
BASF currently produces the acid via a two-step process in which methanol and elemental sulfur react to give dimethyl disulfide, which is then oxidized to the final product.


For decades, chemists tried to find a way to prepare Methane Sulfonic Acid (MSA) from methane and sulfur trioxide under much milder conditions than were used in the original method.
In 2015, Grillo-Werke (Duisburg, Germany), in a world patent application, described the preparation of alkanesulfonic acids from alkanes and SO3 in the presence of an organic peroxide at temperatures up to 65 ºC and pressures up to 11 MPa.


In June of this year, Grillo announced plans to compete with BASF by building a plant to produce Methane Sulfonic Acid (MSA) with a process that is likely based on that patent.
Methane Sulfonic Acid (MSA), the simplest alkanesulfonic acid, is a hygroscopic colorless liquid that freezes around 19 °C.


Methane Sulfonic Acid (MSA) has similar proprieties respect sulfuric acid, but it does not show its oxidant character.
Methane Sulfonic Acid (MSA)’s non-volatility and solubility properties make it industrially valuable as a catalyst in organic reactions, mainly for polymerizations, esterifications and transesterificatios, for electroplating bath and as reagent to form amine salts for pharmaceutical drug delivery purposes.


Another feature that makes Methane Sulfonic Acid (MSA) convenient for industrial applications is its liquid state at room temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid.
Methane Sulfonic Acid (MSA) is considered a particularly suitable supporting electrolyte for electrochemical applications, where it stands as an environmentally friendly alternative to other acid electrolytes used in plating processes.


Methane Sulfonic Acid (MSA) is also a primary ingredient in rust remover and descaler.
Methane Sulfonic Acid (MSA) is recommended in formulation for removing rust from ceramic, tiles and porcelain surfaces which are usually susceptible to acid attack.


Methane Sulfonic Acid (MSA) is an organic sulfuric acid, a colorless liquid with the molecular formula CH3SO3H.
The salts and esters of Methane Sulfonic Acid (MSA) are called mesilates (or methanesulfonates, as ethyl methanesulfonate).
In its concentrated form it is hygroscopic.


Methane Sulfonic Acid (MSA) is capable of dissolving a wide range of metal salts, many of which are in much higher concentrations than hydrochloric acid (HCl) or sulfuric acid (H2SO4).
Methane Sulfonic Acid (MSA) has become a popular substitute for other acids in many industrial and laboratory applications.


Methane Sulfonic Acid (MSA) belongs to the class of organic compounds known as organosulfonic acids in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane Sulfonic Acid (MSA) is a hygroscopic colorless liquid or white solid.


Methane Sulfonic Acid (MSA) is very soluble in water and oxygenated solvents, but sparingly soluble in most
hydrocarbons.
Methane Sulfonic Acid (MSA) is a strong, odorless and less corrosive acid.


Methane Sulfonic Acid (MSA) is not harmful to systems, employees, customers, waste management or the environment when used in chemical synthesis, metal refinement or industrial cleaning.
Methane Sulfonic Acid (MSA) can be used sparingly and saves energy.


Additional advantages are the high solubility of its salts, its lack of color and the fact that Methane Sulfonic Acid (MSA) is readily biodegradable (according to OECD Directive 301 A).
The acid strength of the organic Methane Sulfonic Acid (MSA) is between that of carboxylic acids and strong mineral acids.



USES and APPLICATIONS of METHANE SULFONIC ACID (MSA):
Wide Applications of Methane Sulfonic Acid (MSA): Perfect for electroplating, organic reactions, polymerization, and more.
Methane Sulfonic Acid (MSA) is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.
Methane Sulfonic Acid (MSA) can be used in the generation of borane (BH3) by reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMSO, the complex of BH3 and the solvent is formed.


Methane Sulfonic Acid (MSA) is widely used as catalyst or salifying agent replacing the more toxic, corrosive and less biodegradable mineral acids
In the chemical industry, Methane Sulfonic Acid (MSA) is a substance for the formation of secondary methane sulfonates from olefins, a chemical for the production of trifluoromethanesulfonic acid, and for the production of methane sulfonyl chloride.


Catalyst in esterification, alkylation, olefin polymerization, peroxidation reactions.
In electrical engineering, Methane Sulfonic Acid (MSA) is used to etch pressed electrical panels.
Methane Sulfonic Acid (MSA) is used as an alternative to inorganic acids because it not only performs its function well but also does not corrode the metals of the plates.


This prolongs the service life of the plates.
Methane Sulfonic Acid (MSA) is capable of dissolving a wide range of metal salts, many of which are in much higher concentrations than hydrochloric acid (HCl) or sulfuric acid (H2SO4).


Methane Sulfonic Acid (MSA) has become a popular substitute for other acids in many industrial and laboratory applications.
The closest analogue, p-toluenesulfonic acid (PTSA), is solid
used in detergents because it does not cause eutrophication in water bodies.


In the electroplating industry, Methane Sulfonic Acid (MSA) solutions are used to electroplate tin and tin-lead alloys.
Methane Sulfonic Acid (MSA) displaces fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.
Methane Sulfonic Acid (MSA) is used as an electrolyte in electroplating processes such as nickel plating, copper plating and tin plating.


Methane Sulfonic Acid (MSA) acts as a buffer to maintain the pH of the electrolyte solution and to help ensure uniform coverage of the metal substrate.
In metals processing and extraction, Methane Sulfonic Acid (MSA) is of particular interest in lead hydrometallurgy, where it is a greener alternative to HBF4 and H2SiF6.


However, Methane Sulfonic Acid (MSA) can also be used in all hydrometallurgical processes that require strong Brønsted acids.
Methane Sulfonic Acid (MSA) can be used in copper, zinc, cobalt, nickel and rare earth metallurgy, as well as in the recycling of metals from discarded products.


For example, if CaO, Ca(OH)2 or CaCO3 is used to neutralize excess Methane Sulfonic Acid (MSA) after leaching, and the metals have been removed from the saturated leach solution by precipitation as hydroxides or sulfides, there will be a significant amount of dissolved calcium methanesulfonate in the raffinate.


The addition of sulfuric acid to this solution results in the precipitation of CaSO4-2H2O (gypsum) and the Methane Sulfonic Acid (MSA) is recovered and can be reused.
Similarly, silver can be recovered from Methane Sulfonic Acid (MSA) salt solutions by adding hydrochloric acid.


This produces a sparingly soluble silver (I) chloride which precipitates out.
Rare earth elements (REE) can be recovered from Methane Sulfonic Acid (MSA) solutions by the addition of oxalic acid.
In order to develop a new MSA-based process for the refining of recycled raw silver from secondary resources, the characteristics of silver metal pellet dissolution in Methane Sulfonic Acid (MSA) were investigated.


Although Methane Sulfonic Acid (MSA) alone did not dissolve the pellets, they were dissolved by the addition of hydrogen peroxide as an oxidant.
Silver pellets containing about 94 % silver together with other precious metals such as gold and PGMs were successfully dissolved with a mixture of Methane Sulfonic Acid (MSA) and hydrogen peroxide.


The high solubility of methanesulfonate salts compared to sulphate and chloride salts is also useful for the recovery of Methane Sulfonic Acid (MSA) in process solutions after removal of precious metals.
The extraction yields were found to be in excess of 90 %, with solid-liquid ratios of up to 550 g/L and a stoichiometric excess of hydrogen peroxide of three times.


The optimum yield was found to be between 65 °C and 85 °C.
A high selectivity for palladium was achieved: only 7 % of palladium dissolved together.
The dissolution residue consisted mainly of gold and undissolved silver, with small amounts of palladium and platinum.


A negative correlation was observed between the solubility of silver(I) methanesulphonate and the concentration of free Methane Sulfonic Acid (MSA) after leaching.
Methane Sulfonic Acid (MSA) has been shown to be an effective solvent for dissolving the cathode material of LiCoO2 lithium ion batteries.


With a small amount of hydrogen peroxide as a reducing agent (0,9 % by volume), lithium and cobalt could be leached very efficiently with a 1 M Methane Sulfonic Acid (MSA) solution.
Methane Sulfonic Acid (MSA) performed much better than the other organic acids tested (citric acid, malonic acid, succinic acid and oxalic acid).


Dissolved cobalt precipitated as CoCO3 and was calcined to Co3O4, while dissolved lithium precipitated as Li2CO3 with the addition of Na2CO3 solution.
Li2CO3 and Co3O4 were combined in a solid state to form the new cathode material LiCoO2.
In pharmaceuticals, Methane Sulfonic Acid (MSA) is very suitable for the production of active pharmaceutical ingredients such as telmisartan and eprosartan, angiotensin II receptor antagonists.


Methane Sulfonic Acid (MSA) plays an important role in a wide range of pharmaceutical applications, from the synthesis of active pharmaceutical ingredients (APIs) to drug formulation.
As a catalyst, Methane Sulfonic Acid (MSA) facilitates key reactions in the synthesis of APIs such as esterification, acylation and sulfonation.


Methane Sulfonic Acid (MSA) is also used in drug formulation processes where it helps to solubilize and stabilize active compounds.
Methane Sulfonic Acid (MSA)'s compatibility with various solvents and its mild nature contribute to the development of safe and effective pharmaceutical formulations.


Methane Sulfonic Acid (MSA) and other lower alkanesulfonic acids are useful for plating of lead, nickel, cadmium, silver, and zinc.
Methane Sulfonic Acid (MSA) also finds use in plating of tin, copper, lead, and other metals and is used in printed circuit board manufacture.
Methane Sulfonic Acid (MSA) finds use in ion-exchange resin regeneration because of the high solubility of many metal salts in aqueous solutions.


Methane Sulfonic Acid (MSA) is also used as catalyst in esterification, alkylation, olefin polymerization, peroxidation
reactions.
Methane Sulfonic Acid (MSA) is also a primary ingredient in rust and scale removers.


Methane Sulfonic Acid (MSA) is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.
Methane Sulfonic Acid (MSA) side chain was utilized in pharmaceutical products Novalgin (metamizole) & Methaniazide.
Methane Sulfonic Acid (MSA) is used as a solvent and as a catalyst for alkylations, esterifications and polymerizations.


Methane Sulfonic Acid (MSA) is used Agricultural Chemicals, Crop Protection, Curing Agent, Electronic Chemicals, Flavor & Fragrance, Household, Industrial & Institutional Chemicals, Industrial Chemicals, Inks & Digital Inks, Lithium Battery & Electrolyte Chemicals, Lubricant & Grease, Metal Plating, Metal Working, Finishing & Flux, Personal Care & Cosmetics, Pharmaceutical & Fine Chemicals, Plastic, Resin & Rubber, Textile Auxiliaries, Catalysts, Coatings, Pesticides, Solvents.


Since Methane Sulfonic Acid (MSA) is odorless, it may also be used in odor-sensitive applications.
Its lack of smell also increases safety at work because Methane Sulfonic Acid (MSA) does not produce any acrid fumes.
Methane Sulfonic Acid (MSA) is very suitable for neutralisation of vegetable oils with high FFA content.


In pharmaceuticals, Methane Sulfonic Acid (MSA) is very suitable for the production of active pharmaceutical ingredients such as telmisartan and eprosartan, angiotensin II receptor antagonists.
Methane Sulfonic Acid (MSA) plays an important role in a wide range of pharmaceutical applications, from the synthesis of active pharmaceutical ingredients (APIs) to drug formulation.


As a catalyst, Methane Sulfonic Acid (MSA) facilitates key reactions in the synthesis of APIs such as esterification, acylation and sulfonation.
Methane Sulfonic Acid (MSA)'s efficiency in promoting these reactions allows the efficient production of pharmaceutical intermediates and final APIs.
Methane Sulfonic Acid (MSA) is also used in drug formulation processes where it helps to solubilize and stabilize active compounds.


Methane Sulfonic Acid (MSA)'s compatibility with various solvents and its mild nature contribute to the development of safe and effective pharmaceutical formulations.
Its efficiency in promoting these reactions allows the efficient production of pharmaceutical intermediates and final APIs.


-In oil industry (well stimulation):
Methane Sulfonic Acid (MSA) is used in the oilfield industry for acidification treatments that increase production by dissolving mineral deposits and improving reservoir permeability.
Methane Sulfonic Acid (MSA) acts as a catalyst to break down complex hydrocarbons and increase oil recovery efficiency.

Methane Sulfonic Acid (MSA) has lower corrosion and biodegradability, resulting in reduced equipment corrosion and longer service life, and lower maintenance costs.
In addition, the biodegradable properties of Methane Sulfonic Acid (MSA) contribute to environmentally friendly oilfield operations.


-Electroplating uses of Methane Sulfonic Acid (MSA):
Solutions of Methane Sulfonic Acid (MSA) are used for the electroplating of tin and tin-lead solders.
Methane Sulfonic Acid (MSA) is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.


-In oil industry (well stimulation):
Methane Sulfonic Acid (MSA) is used in the oilfield industry for acidification treatments that increase production by dissolving mineral deposits and improving reservoir permeability.
Methane Sulfonic Acid (MSA) acts as a catalyst to break down complex hydrocarbons and increase oil recovery efficiency.

Methane Sulfonic Acid (MSA) has lower corrosion and biodegradability, resulting in reduced equipment corrosion and longer service life, and lower maintenance costs.
In addition, the biodegradable properties of Methane Sulfonic Acid (MSA) contribute to environmentally friendly oilfield operations.


-In the cleaning industry, Methane Sulfonic Acid (MSA) is a key ingredient in rust and plaque removers from acid-sensitive surfaces.
Methane Sulfonic Acid (MSA) is used to clean rust from ceramics, tiles and porcelain, which are generally sensitive to strong acids.

Methane Sulfonic Acid (MSA) is an excellent alternative to traditional phosphoric acid-based rust removers/cleaners as it is not inferior in cleaning performance and does not contribute to eutrophication (water damage) when discharged into wastewater.

This property is particularly relevant for operators of individual sewage treatment plants, as Methane Sulfonic Acid (MSA) does not impair their operation and does not damage the water bodies into which the treated wastewater is discharged.


-Use as a solvent:
Methane Sulfonic Acid (MSA) is not only an excellent catalyst for the chitin acylation process but also a good solvent for partially acylated chitin.
Therefore, homogeneous chitin acylation can be achieved in the Methane Sulfonic Acid (MSA) system.
Methane Sulfonic Acid (MSA) is used as a solvent for high molecular weight polymers.


-In water systems, Methane Sulfonic Acid (MSA) is used for regeneration of water softening filter charges.
Methane Sulfonic Acid (MSA) is well suited because it does not damage anion exchange and cation exchange resins and reacts well with the metals on their surface, thus opening the active centres of the resins and allowing the charges to operate at full capacity.


-In the electrical industry, Methane Sulfonic Acid (MSA) is used to dissolve lead salts to produce the electrolyte in bipolar batteries.
Methane Sulfonic Acid (MSA) has the advantage of eliminating the parasitic reactions that inhibit the storage/generation of chemical electricity, greatly simplifying the battery design, and allowing the production of energy storage/batteries in a wide range of sizes.



OVERVIEW OF METHANE SULFONIC ACID (MSA):
Methane Sulfonic Acid (MSA)is an organic acid with the chemical formula CH3SO3H.
Methane Sulfonic Acid (MSA) is a colorless, viscous liquid that is soluble in water and polar organic solvents.
Methane Sulfonic Acid (MSA) is a strong acid, meaning that it readily donates protons (H+) to other molecules in solution.
Methane Sulfonic Acid (MSA) is commonly used in organic synthesis and as a catalyst in various chemical reactions.
Thanks to its versatility, Methane Sulfonic Acid (MSA) is a viable substitute for organic and inorganic strong acids in a variety of applications.



CHEMICAL STRUCTURE OF METHANE SULFONIC ACID (MSA):
The chemical structure of Methane Sulfonic Acid (MSA) consists of a central carbon atom (C) bonded to three hydrogen atoms (H).
One of the hydrogen atoms is also bonded to a sulfur atom (S), and the sulfur atom is further bonded to three oxygen atoms (O).
These oxygen atoms are also bonded to a hydrogen atom each.
This arrangement gives Methane Sulfonic Acid (MSA) its distinct properties as a strong organic acid.



PHYSICAL PROPERTIES OF METHANE SULFONIC ACID (MSA):
Colorless or light yellow liquid
Odorless or with a slight sulfuric odor
Highly soluble in water forming a homogeneous solution and is miscible with most polar organic solvents.
Relatively high density (~1.48 g/mL at room temperature)
High boiling point (~167°C or 332°F)



HISTORY AND MANUFACTURING OF METHANE SULFONIC ACID (MSA):
The first commercial production of Methane Sulfonic Acid (MSA), developed in the 1940s by Standard Oil of Indiana, was based on oxidation of dimethylsulfide by O2 from air.
Although inexpensive, this process suffered from a poor product quality and explosion hazards.

In 1967, the Pennwalt Corporation (USA) developed a different process for dimethylsulfide (as an water-based emulsion) oxidation using chlorine, followed by extraction-purification.
In 2022 this chlorine-oxidation process was used only by Arkema (France) for making high-purity MSA.
This process is not popular on a large scale, because it co-produces large quantities of hydrochloric acid.

Between years 1970 and 2000 Methane Sulfonic Acid (MSA) was used only on a relatively small-scale in niche markets (for example, in the microelectronic and electroplating industries since the 1980s), which was mainly due to its rather high price and limited availability.

However, this situation changed around 2003, when BASF launched commercial production of Methane Sulfonic Acid (MSA) in Ludwigshafen based on a modified version of the aforementioned air oxidation process, using dimethyldisulfide instead of dimethylsulfoxide.
The former is produced in one step from methanol from syngas, hydrogen and sulfur.

An even better (lower-cost and environmentally friendlier) process of making Methane Sulfonic Acid (MSA) was developed in 2016 by Grillo-Werke AG (Germany).
Methane Sulfonic Acid (MSA) is based on a direct reaction between methane and oleum at around 50 °C and 100 bar in the presence of a potassium persulfate initiator.
This technology was acquired and commercialized by BASF in 2019.



PHYSICAL and CHEMICAL PROPERTIES of METHANE SULFONIC ACID (MSA):
Chemical formula: CH₄O₃S
Molar mass: 96.10 g·mol⁻¹
Appearance: Clear, colourless liquid
Density: 1.48 g/cm³
Melting point: 17 to 19 °C (63 to 66 °F; 290 to 292 K)
Boiling point: 167 °C (333 °F; 440 K) at 10 mmHg, 122 °C/1 mmHg
Solubility in water: Miscible
Solubility: Miscible with methanol, diethyl ether.
Immiscible with hexane
log P: −2.424
Acidity (pKa): −1.9
Molecular Weight: 96.11 g/mol
XLogP3-AA: -0.9
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 0
Exact Mass: 95.98811516 g/mol
Monoisotopic Mass: 95.98811516 g/mol

Topological Polar Surface Area: 62.8 Ų
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 92.6
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical State: Liquid
Color: Light Yellow
Odor: Characteristic
Melting Point/Freezing Point: 17 - 19 °C
Initial Boiling Point and Boiling Range: 167 °C at 13 hPa
Flammability: No data available

Upper/Lower Flammability or Explosive Limits:
Upper Explosion Limit: 24.3% (V)
Lower Explosion Limit: 11.4% (V)
Flash Point: 189 °C (Closed Cup - DIN 51755 Part 1)
Autoignition Temperature: 535 °C at 1.010 hPa (DIN 51794)
Decomposition Temperature: No data available
pH: < 1 at 20 °C
Viscosity:
Kinematic Viscosity: 7.86 mm²/s at 25 °C
Dynamic Viscosity: 11.6 mPa·s at 25 °C
Water Solubility: Approximately 1,000 g/L at 20 °C (Completely Miscible)
Partition Coefficient (n-octanol/water):
Log Pow: -2.38 at 20 °C
Vapor Pressure: 0.112 hPa at 80 °C (OECD Test Guideline 104)
Density: 1.481 g/cm³ at 25 °C
Dissociation Constant: -1.54 at 25 °C
Relative Vapor Density: 3.32 (Air = 1.0)
CAS number: 75-75-2

EC index number: 607-145-00-4
EC number: 200-898-6
Hill Formula: CH₄O₃S
Chemical formula: CH₃SO₃H
Molar Mass: 96.11 g/mol
HS Code: 2904 10 11
Boiling point: 167 °C (13 hPa)
Density: 1.4812 g/cm3 (18 °C)
Flash point: 189 °C
Melting Point: 20 °C
pH value: Vapor pressure: 0.112 hPa (80 °C)
Solubility: 1000 g/l
CBNumber:CB3433704
Molecular Formula:CH4O3S
Molecular Weight:96.11
MDL Number:MFCD00007518

MOL File:75-75-2.mol
Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
vapor density: 3.3 (vs air)
vapor pressure: 1 mm Hg ( 20 °C)
refractive index: n20/D 1.429(lit.)
Flash point: >230 °F
storage temp.: 2-8°C
solubility: water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
form: Solution
color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water.
Slightly miscible with benzene and toluene.
Immiscible with paraffins.

λmax: λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024
Stability: Stable.
Moisture sensitive.
Incompatible with amines, bases, water, common metals.
Releases a substantial amount of heat when diluted with water
(add acid to water with care if diluting).
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference: 75-75-2(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 12EH9M7279
NIST Chemistry Reference: CH3SO3H(75-75-2)
EPA Substance Registry System: Methanesulfonic acid (75-75-2)
Melting Point: 19.0°C
Density: 1.4810g/mL
Boiling Point: 167.0°C (10.0 mmHg)
Flash Point: 189°C

Infrared Spectrum: Authentic
Assay Percent Range: 99%
Refractive Index: 1.4252 to 1.4315
Linear Formula: CH3SO3H
Beilstein: 04, 4
Fieser 01,666; 02,270; 04,326; 10,256; 11,321; 12,212; 13,176
Specific Gravity: 1.481
Merck Index: 15, 6026
Solubility Information: Solubility in water: soluble.
Other solubilities: soluble in alcohol, ether and ethanol,
insoluble in hexane and methylcyclopentane,
1.50wt% benzene: -0.23wt% 0-chlorotoluene (26-28°C),
0.38wt% toluene: -0.47wt% ethyl disulfide (26-28°C)
Viscosity: 11.6 mPa.s (25°C)
Formula Weight: 96.1
Percent Purity: 99%
Grade: Extra Pure
Physical Form: Liquid
Chemical Name or Material: Methanesulfonic acid



FIRST AID MEASURES of METHANE SULFONIC ACID (MSA):
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Call a physician immediately.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water.
Call a physician immediately.
Do not attempt to neutralise.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of METHANE SULFONIC ACID (MSA):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent and neutralising material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of METHANE SULFONIC ACID (MSA):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Dry powder
Water
Foam
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system



EXPOSURE CONTROLS/PERSONAL PROTECTION of METHANE SULFONIC ACID (MSA):
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 60 min
*Body Protection:
Acid-resistant protective clothing
*Respiratory protection:
Recommended Filter type: Filter type B
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of METHANE SULFONIC ACID (MSA):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
No metal containers.
Tightly closed.
Heat sensitive.
Hygroscopic.



STABILITY and REACTIVITY of METHANE SULFONIC ACID (MSA):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .


METHANE SULFONIC ACID 70%
METHANE SULFONIC ACID 70% Ludwigshafen, Germany – December 20, 2018 – BASF intends to expand the production capacity for methane sulfonic acid (MSA) at its Ludwigshafen site by around 65 percent and increase the global capacity to 50,000 metric tons per year. With the investment the company further strengthens its position as the leading global producer of MSA. The volumes from the additional capacity are expected to be available late in 2021 for customers in all regions. “The demand for MSA increased strongly across industries. This expansion will allow us to support the rapid growth of our customers, especially in Asia. Beyond the increase in Ludwigshafen, we evaluate investment options outside of Europe to continuously expand our MSA capacities,” says Martin Widmann, Global Strategic Marketing and Development, Care Chemicals division at BASF. “We focus our extensive know-how and highly efficient manufacturing processes on our customers’ needs to enhance their applications’ performance, sustainability and efficacy." Sustainable alternative to conventional acids Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. The expansion is in line with the trend for top-performance and at the same time environmentally friendly technologies in various industries. BASF’s proprietary process enables the production of Lutropur® MSA – a high-purity methane sulfonic acid. Lutropur MSA is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle MSA is readily biodegradable. Further benefits in practical applications come, for example, from its nonoxidizing nature, the high solubility of its salts and the absence of color and odor. As already announced at the end of 2018, BASF will proceed with expanding global capacities for methane sulfonic acid (MSA) to 50,000 metric tons per year. This involves a higher double-digit million euro investment in constructing a new methane sulfonic acid plant at the Ludwigshafen site. The construction works started recently. The volumes from the additional capacity are expected to be available from the end of 2021 and are dedicated to mainly serve European customers as well as the rapidly growing Asian market. “We want to meet our customers' growing demand for high-quality, sustainable and high-performance technologies in the best possible way now and in future. To achieve that, we continuously invest in expanding our capacities and production technologies. To this end, we acquired an innovative process approach for producing MSA from Grillo-Werke AG in mid 2019 to strengthen our own R&D activities and to accelerate the development of a new manufacturing process for methane sulfonic acid. In doing so, we support as reliable partner the growth of our customers across the world,” said Ralph Schweens, President Care Chemicals, BASF. Sustainable alternative to conventional acids Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. BASF's high-purity methane sulfonic acid – sold under the brand name Lutropur® MSA – is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle, Lutropur MSA is readily biodegradable. Further benefits of using methane sulfonic acid come from its non-oxidizing character, the high solubility of its salts and the absence of color and odor. Product overview MSA (Methane Sulfonic Acid 70% - CAS 75-75-2) is a strong acid widely used as a catalyst (esterification, alkylation, etc.) thanks to its performances, it is an interesting substitute for organic and inorganic strong acids in various applications. Ester quality, easy recyclability and "green" effluent are part of the major methane sulfonic acid 70% advantage is in esterification. Methane sulfonic acid 70% Jump to navigationJump to search Methane sulfonic acid 70% Structural formula of Methane sulfonic acid 70% Ball-and-stick model of Methane sulfonic acid 70% Names IUPAC name Methane sulfonic acid 70% Other names Methylsulfonic acid, MSA Identifiers CAS Number 75-75-2 check 3D model (JSmol) Interactive image ChEBI CHEBI:27376 check ChemSpider 6155 check ECHA InfoCard 100.000.817 Edit this at Wikidata EC Number 200-898-6 PubChem CID 6395 UNII 12EH9M7279 check CompTox Dashboard (EPA) DTXSID4026422 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula CH4O3S Molar mass 96.10 g·mol−1 Appearance Clear, colourless liquid Density 1.48 g/cm3 Melting point 17 to 19 °C (63 to 66 °F; 290 to 292 K) Boiling point 167 °C (333 °F; 440 K) at 10 mmHg, 122 °C/1 mmHg Solubility in water miscible Solubility Miscible with methanol, diethyl ether. Immiscible with hexane log P -2.424[1] Acidity (pKa) −1.9[2] Hazards Safety data sheet Oxford MSDS EU classification (DSD) (outdated) Harmful (Xn), Corrosive (C) Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). check verify (what is check☒ ?) Infobox references Methane sulfonic acid 70% (MsOH) or methanesulphonic acid (in British English) is a colorless liquid with the chemical formula CH3SO3H. It is the simplest of the alkylsulfonic acids. Salts and esters of Methane sulfonic acid 70% are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate). It is hygroscopic in its concentrated form. Methane sulfonic acid 70% may be considered an intermediate compound between sulfuric acid (H2SO4), and methylsulfonylmethane ((CH3)2SO2), effectively replacing an –OH group with a –CH3 group at each step. This pattern can extend no further in either direction without breaking down the –SO2– group. Methane sulfonic acid 70% can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric or sulfuric acid.[3] Contents 1 Applications 1.1 Electroplating 2 See also 3 References Applications Methane sulfonic acid 70% is used as an acid catalyst in organic reactions because it is a non-volatile, strong acid that is soluble in organic solvents. It is convenient for industrial applications because it is liquid at ambient temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid. However, in a laboratory setting, solid PTSA is more convenient. Methane sulfonic acid 70% can be used in the generation of borane (BH3) by reacting Methane sulfonic acid 70% with NaBH4 in an aprotic solvent such as THF or DMS, the complex of BH3 and the solvent is formed.[4] Electroplating Solutions of Methane sulfonic acid 70% are used for the electroplating of tin and tin-lead solders. It is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.[5] Methane sulfonic acid 70% is also a primary ingredient in rust and scale removers.[6] It is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack. See also TrifluoroMethane sulfonic acid 70% - the more acidic trifluoro analogue 4.3.3.2.1 Methane sulfonic acid 70% system Methane sulfonic acid 70% with high acidity is not only the catalyst in the process of chitin acylation, but also is a good solvent for partially acylated chitin. Thus homogeneous acylation of chitin can be achieved in the Methane sulfonic acid 70% system. Norio et al. [75] mixed chitin, Methane sulfonic acid 70%, and glacial acetic acid according to different molar ratios, and reacted it at 0°C overnight to obtain acetylated chitin with different DS. In this experiment, a homogeneous phase is gradually formed as the reaction proceeds, which contributes to further acylation. This reaction should be kept at a low temperature to prevent degradation of chitin in acidic conditions. The acylating agent is not limited to carboxylic acid but also acid chloride. Furthermore, Kaifu et al. [78] mixed the chitin, Methane sulfonic acid 70%, and acid chloride first, then the mixture was reacted at 0°C for 2 h, followed by an overnight reaction at –20°C to obtain acylated chitin. By changing the kind and molar amount of acid chloride, hexanoylation, oxime acylation, and dodecyl acylation of chitin with different DS can be obtained, of which DS can be up to 1.9. In this process, the crystallinity of chitin can be effectively destroyed by further acylation by reacting at –20°C overnight. In general, the acylation ability of the acid chloride is higher than that of the carboxylic acid. The larger the acylation group, the greater the damage to the crystalline region of chitin. c. Dilute Methane sulfonic acid 70% in Dioxane–Dichloromethane This diluted Methane sulfonic acid 70% (MSA) system, which uses 0.5 M MSA in 1:9 (v/v) dioxane–CH2Cl2 (Kiso et al., 1992b), is primarily used in SPPS. The advantages are as follows: (i) elimination of side-chain protecting groups is reduced compared to the conventional 45% TFA/CH2Cl2 method, and (ii) pyroglutamyl formation from glutamine-containing peptides is similarly decreased relative to the use of 4 N HCl/dioxane. Using the MSA deprotection system, Kiso et al. (1990a) developed an efficient method for SPPS consisting of in situ neutralization and the rapid coupling reaction using BOP or BOI reagent activation (Kiso et al., 1990a) (Fig. 7). Porcine brain natriuretic peptide (pBNP) was synthesized successfully using this method (Kiso et al., 1992b). 10.14.10.6 DMSO and Methane sulfonic acid 70% DMSO and Methane sulfonic acid 70% are two of the most important organic oxidation products of DMS. It is not entirely clear how Methane sulfonic acid 70%, CH3S(O)(O)(OH), forms, but methanesulfinic acid, CH3S(O)(OH)CH3, has been reported during oxidation in OH–DMS systems. Further addition of OH to methanesulfinic acid, followed by reaction with oxygen, can yield Methane sulfonic acid 70%. At lower temperatures found in the Arctic, there are a wide variety of oxidation products of DMS that include the MSA, DMS, and dimethylsulfone, CH3S(O)(O)CH3. WHAT IS METHANE SULPHONIC ACID 70% Methane sulphonic acid 70%, also known as methane sulfonic acid 70% or mesylic acid. It is widely used as an acid catalyst and solvent in organic reactions in biological and agricultural industry. It is also a key ingredient in plating various metals to print circuit board manufacture in electric industry. Besides, Methane sulphonic acid 70% is popularly used in textile treatment, and the production of plastics and polymers. Synonyms: Methane sulfonic acid 70%, Methane sulphonic acid 70%, Mesylate, Methylsulfonate, Methane sulfonic acid 70%, MSA INCI: Methane Sulphonic Acid Chemical Formula: CH3SO3H CAS Number: CAS 75-75-2 Ludwigshafen, Germany – December 20, 2018 – BASF intends to expand the production capacity for methane sulfonic acid (MSA) at its Ludwigshafen site by around 65 percent and increase the global capacity to 50,000 metric tons per year. With the investment the company further strengthens its position as the leading global producer of MSA. The volumes from the additional capacity are expected to be available late in 2021 for customers in all regions. “The demand for MSA increased strongly across industries. This expansion will allow us to support the rapid growth of our customers, especially in Asia. Beyond the increase in Ludwigshafen, we evaluate investment options outside of Europe to continuously expand our MSA capacities,” says Martin Widmann, Global Strategic Marketing and Development, Care Chemicals division at BASF. “We focus our extensive know-how and highly efficient manufacturing processes on our customers’ needs to enhance their applications’ performance, sustainability and efficacy." Sustainable alternative to conventional acids Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. The expansion is in line with the trend for top-performance and at the same time environmentally friendly technologies in various industries. BASF’s proprietary process enables the production of Lutropur® MSA – a high-purity methane sulfonic acid. Lutropur MSA is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle MSA is readily biodegradable. Further benefits in practical applications come, for example, from its nonoxidizing nature, the high solubility of its salts and the absence of color and odor. As already announced at the end of 2018, BASF will proceed with expanding global capacities for methane sulfonic acid (MSA) to 50,000 metric tons per year. This involves a higher double-digit million euro investment in constructing a new methane sulfonic acid plant at the Ludwigshafen site. The construction works started recently. The volumes from the additional capacity are expected to be available from the end of 2021 and are dedicated to mainly serve European customers as well as the rapidly growing Asian market. “We want to meet our customers' growing demand for high-quality, sustainable and high-performance technologies in the best possible way now and in future. To achieve that, we continuously invest in expanding our capacities and production technologies. To this end, we acquired an innovative process approach for producing MSA from Grillo-Werke AG in mid 2019 to strengthen our own R&D activities and to accelerate the development of a new manufacturing process for methane sulfonic acid. In doing so, we support as reliable partner the growth of our customers across the world,” said Ralph Schweens, President Care Chemicals, BASF. Sustainable alternative to conventional acids Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. BASF's high-purity methane sulfonic acid – sold under the brand name Lutropur® MSA – is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle, Lutropur MSA is readily biodegradable. Further benefits of using methane sulfonic acid come from its non-oxidizing character, the high solubility of its salts and the absence of color and odor. Product overview MSA (Methane Sulfonic Acid 70% - CAS 75-75-2) is a strong acid widely used as a catalyst (esterification, alkylation, etc.) thanks to its performances, it is an interesting substitute for organic and inorganic strong acids in various applications. Ester quality, easy recyclability and "green" effluent are part of the major methane sulfonic acid 70% advantage is in esterification. Methane sulfonic acid 70% Jump to navigationJump to search Methane sulfonic acid 70% Structural formula of Methane sulfonic acid 70% Ball-and-stick model of Methane sulfonic acid 70% Names IUPAC name Methane sulfonic acid 70% Other names Methylsulfonic acid, MSA Identifiers CAS Number 75-75-2 check 3D model (JSmol) Interactive image ChEBI CHEBI:27376 check ChemSpider 6155 check ECHA InfoCard 100.000.817 Edit this at Wikidata EC Number 200-898-6 PubChem CID 6395 UNII 12EH9M7279 check CompTox Dashboard (EPA) DTXSID4026422 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula CH4O3S Molar mass 96.10 g·mol−1 Appearance Clear, colourless liquid Density 1.48 g/cm3 Melting point 17 to 19 °C (63 to 66 °F; 290 to 292 K) Boiling point 167 °C (333 °F; 440 K) at 10 mmHg, 122 °C/1 mmHg Solubility in water miscible Solubility Miscible with methanol, diethyl ether. Immiscible with hexane log P -2.424[1] Acidity (pKa) −1.9[2] Hazards Safety data sheet Oxford MSDS EU classification (DSD) (outdated) Harmful (Xn), Corrosive (C) Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). check verify (what is check☒ ?) Infobox references Methane sulfonic acid 70% (MsOH) or methanesulphonic acid (in British English) is a colorless liquid with the chemical formula CH3SO3H. It is the simplest of the alkylsulfonic acids. Salts and esters of Methane sulfonic acid 70% are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate). It is hygroscopic in its concentrated form. Methane sulfonic acid 70% may be considered an intermediate compound between sulfuric acid (H2SO4), and methylsulfonylmethane ((CH3)2SO2), effectively replacing an –OH group with a –CH3 group at each step. This pattern can extend no further in either direction without breaking down the –SO2– group. Methane sulfonic acid 70% can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric or sulfuric acid.[3] Contents 1 Applications 1.1 Electroplating 2 See also 3 References Applications Methane sulfonic acid 70% is used as an acid catalyst in organic reactions because it is a non-volatile, strong acid that is soluble in organic solvents. It is convenient for industrial applications because it is liquid at ambient temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid. However, in a laboratory setting, solid PTSA is more convenient. Methane sulfonic acid 70% can be used in the generation of borane (BH3) by reacting Methane sulfonic acid 70% with NaBH4 in an aprotic solvent such as THF or DMS, the complex of BH3 and the solvent is formed.[4] Electroplating Solutions of Methane sulfonic acid 70% are used for the electroplating of tin and tin-lead solders. It is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.[5] Methane sulfonic acid 70% is also a primary ingredient in rust and scale removers.[6] It is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack. See also TrifluoroMethane sulfonic acid 70% - the more acidic trifluoro analogue 4.3.3.2.1 Methane sulfonic acid 70% system Methane sulfonic acid 70% with high acidity is not only the catalyst in the process of chitin acylation, but also is a good solvent for partially acylated chitin. Thus homogeneous acylation of chitin can be achieved in the Methane sulfonic acid 70% system. Norio et al. [75] mixed chitin, Methane sulfonic acid 70%, and glacial acetic acid according to different molar ratios, and reacted it at 0°C overnight to obtain acetylated chitin with different DS. In this experiment, a homogeneous phase is gradually formed as the reaction proceeds, which contributes to further acylation. This reaction should be kept at a low temperature to prevent degradation of chitin in acidic conditions. The acylating agent is not limited to carboxylic acid but also acid chloride. Furthermore, Kaifu et al. [78] mixed the chitin, Methane sulfonic acid 70%, and acid chloride first, then the mixture was reacted at 0°C for 2 h, followed by an overnight reaction at –20°C to obtain acylated chitin. By changing the kind and molar amount of acid chloride, hexanoylation, oxime acylation, and dodecyl acylation of chitin with different DS can be obtained, of which DS can be up to 1.9. In this process, the crystallinity of chitin can be effectively destroyed by further acylation by reacting at –20°C overnight. In general, the acylation ability of the acid chloride is higher than that of the carboxylic acid. The larger the acylation group, the greater the damage to the crystalline region of chitin. c. Dilute Methane sulfonic acid 70% in Dioxane–Dichloromethane This diluted Methane sulfonic acid 70% (MSA) system, which uses 0.5 M MSA in 1:9 (v/v) dioxane–CH2Cl2 (Kiso et al., 1992b), is primarily used in SPPS. The advantages are as follows: (i) elimination of side-chain protecting groups is reduced compared to the conventional 45% TFA/CH2Cl2 method, and (ii) pyroglutamyl formation from glutamine-containing peptides is similarly decreased relative to the use of 4 N HCl/dioxane. Using the MSA deprotection system, Kiso et al. (1990a) developed an efficient method for SPPS consisting of in situ neutralization and the rapid coupling reaction using BOP or BOI reagent activation (Kiso et al., 1990a) (Fig. 7). Porcine brain natriuretic peptide (pBNP) was synthesized successfully using this method (Kiso et al., 1992b). 10.14.10.6 DMSO and Methane sulfonic acid 70% DMSO and Methane sulfonic acid 70% are two of the most important organic oxidation products of DMS. It is not entirely clear how Methane sulfonic acid 70%, CH3S(O)(O)(OH), forms, but methanesulfinic acid, CH3S(O)(OH)CH3, has been reported during oxidation in OH–DMS systems. Further addition of OH to methanesulfinic acid, followed by reaction with oxygen, can yield Methane sulfonic acid 70%. At lower temperatures found in the Arctic, there are a wide variety of oxidation products of DMS that include the MSA, DMS, and dimethylsulfone, CH3S(O)(O)CH3. WHAT IS METHANE SULPHONIC ACID 70% Methane sulphonic acid 70%, also known as methane sulfonic acid 70% or mesylic acid. It is widely used as an acid catalyst and solvent in organic reactions in biological and agricultural industry. It is also a key ingredient in plating various metals to print circuit board manufacture in electric industry. Besides, Methane sulphonic acid 70% is popularly used in textile treatment, and the production of plastics and polymers. Synonyms: Methane sulfonic acid 70%, Methane sulphonic acid 70%, Mesylate, Methylsulfonate, Methane sulfonic acid 70%, MSA INCI: Methane Sulphonic Acid Chemical Formula: CH3SO3H CAS Number: CAS 75-75-2
METHANE SULPHONIC ACID
Methane sulfonic acid (CH3SO3H, MSA) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methane sulfonic acid in large quantities.
Methane sulfonic acid undergoes biodegradation by forming CO2 and sulphate.

CAS: 75-75-2
MF: CH4O3S
MW: 96.11
EINECS: 200-898-6

Methane sulfonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methane sulfonic acid solution has been considered a model electrolyte for electrochemical processes.
Methane sulfonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane sulfonic acid has a role as an Escherichia coli metabolite.
Methane sulfonic acid is an alkanesulfonic acid and a one-carbon compound.
Methane sulfonic acid is a conjugate acid of a methanesulfonate.

Methane sulfonic acid is a silicone regularly used in haircare products.
Methane sulfonic acid is known as a good silicone as the polymer structure does not stay and build-up on the hair, it simply evaporates.
Methane sulfonic acid gives hair a silky-smooth texture and provides lots of slip, meaning you can run a comb through your hair while it’s soaking wet without causing snagging or tangling, and therefor not damage the hair.

Methane sulfonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane sulfonic acid has a role as an Escherichia coli metabolite.
Methane sulfonic acid is an alkanesulfonic acid and a one-carbon compound.
Methane sulfonic acid is a conjugate acid of a methanesulfonate.
An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.

Methane sulfonic acid (MSA) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methane sulfonic acid in large quantities.
Methane sulfonic acid undergoes biodegradation by forming CO2 and sulphate.
Methane sulfonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methane sulfonic acid solution has been considered a model electrolyte for electrochemical processes.

Methane sulfonic acid Chemical Properties
Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
Vapor density: 3.3 (vs air)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.429(lit.)
Fp: >230 °F
Storage temp.: 2-8°C
Solubility water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
Form: Solution
Color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024
Stability: Stable. Moisture sensitive. Incompatible with amines, bases, water, common metals. Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting).
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference: 75-75-2(CAS DataBase Reference)
NIST Chemistry Reference: CH3SO3H(75-75-2)
EPA Substance Registry System: Methane sulfonic acid (75-75-2)

Methane sulfonic acid, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.
Methane sulfonic acid has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa), the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃).
Methane sulfonic acid is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene.
Methane sulfonic acid will not subject to decomposition in boiling water and hot alkaline solution.
Methane sulfonic acid also has strong corrosion effect against the metal iron, copper and lead.

Methane sulfonic acid is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methane sulfonic acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, methane sulfonic acid is used as a starting material for the preparation of methanesulfonyl chloride.

Uses
Methane sulfonic acid is a raw material for medicine and pesticide.
Methane sulfonic acid can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
Methane sulfonic acid can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry.
Methane sulfonic acid can also be applied to oxidation.
Methane sulfonic acid has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings.
One of the major advantages of methane sulfonic acid over sulfuric acid is that it is not an oxidizing species.
Methane sulfonic acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents.

Methane sulfonic acid is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters.
Methane sulfonic acid reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex.
Methane sulfonic acid finds application in batteries, because of its purity and chloride absence.
In pharmaceutical industry, Methane sulfonic acid is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan.
Methane sulfonic acid is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
Methane sulfonic acid is involved in the deprotection of peptides.
For complete protein and peptide hydrolysis with tryptophan recovery.
After hydrolysis the samples are diluted prior to amino acid analysis.

Production method
Methane sulfonic acid can be obtained through the nitrate oxidation of thiocyanate methyl.
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃.
After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product.
The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered.
The filtrate is condensed to until crystalline precipitation.
The crystal is washed by methanol to remove the nitrate to obtain the barium methane sulfonate.

Methane sulfonic acid is then added to the exchanged water to boiling, add sulfuric acid for decomposition while Methane sulfonic acid is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product.
Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction.
The reaction solution was extracted with chloroform.

After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure.
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride.
Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear.
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain methanesulfonic acid.

Preparation
Methane sulfonic acid is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.

Synonyms
METHANESULFONIC ACID
75-75-2
Methylsulfonic acid
Methanesulphonic acid
Mesylic acid
Methanesulfonicacid
Sulfomethane
Kyselina methansulfonova
Methansulfonsaeure
NSC 3718
CCRIS 2783
HSDB 5004
EINECS 200-898-6
METHANE SULFONIC ACID
BRN 1446024
DTXSID4026422
MSA
UNII-12EH9M7279
CHEBI:27376
Kyselina methansulfonova [Czech]
AI3-28532
NSC-3718
CH3SO3H
MFCD00007518
CH4O3S
12EH9M7279
DTXCID806422
22515-76-0
NSC3718
EC 200-898-6
4-04-00-00010 (Beilstein Handbook Reference)
J1.465F
ammoniummethanesulfonate
METHANESULFONIC ACID (II)
METHANESULFONIC ACID [II]
CH4O3S.H3N
C-H4-O3-S.H3-N
Methanesulfonic acid, ammonium salt
Methanesulfonic acid, ammonium salt (1:1)
metanesulfonic acid
methansulfonic acid
MsOH
methansulphonic acid
methylsulphonic acid
03S
methyl sulfonic acid
methyl-sulfonic acid
methane-sulfonic acid
MeSO3H
methane sulphonic acid
methanesulphonic-acid-
LACTIC ACID(DL)
CH3SO2OH
H3CSO3H
WLN: WSQ1
Methanesulfonic acid solution
Methanesulfonic acid, 99.5%
Methanesulfonic acid, anhydrous
CHEMBL3039600
DL-MALICACIDMONOSODIUMSALT
Methanesulfonic Acid (CH3SO3H)
METHANESULFONIC ACID [MI]
Methanesulfonic acid, HPLC grade
Methanesulfonic acid, >=99.0%
METHANESULFONIC ACID [HSDB]
Tox21_201073
STL264182
AKOS009146947
AT25153
CAS-75-75-2
NCGC00248914-01
NCGC00258626-01
BP-12823
LS-90299
FT-0628287
M0093
M2059
EN300-29198
Methanesulfonic acid, >=99.0%, ReagentPlus(R)
Methanesulfonic acid, for HPLC, >=99.5% (T)
A934985
Q414168
J-521696
Methanesulfonic acid, Vetec(TM) reagent grade, 98%
F1908-0093
Z281776238
InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4
METHANE SULPHONIC ACID
Methane sulfonic acid (CH3SO3H, MSA) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methane sulfonic acid in large quantities.
Methane sulfonic acid undergoes biodegradation by forming CO2 and sulphate.

CAS: 75-75-2
MF: CH4O3S
MW: 96.11
EINECS: 200-898-6

Methane sulfonic acid (MsOH) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH.
Methane sulfonic acid is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).
Salts and esters of methane sulfonic acid are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).
Methane sulfonic acid is hygroscopic in its concentrated form.
Methane sulfonic acid can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).

Methane sulfonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methane sulfonic acid solution has been considered a model electrolyte for electrochemical processes.
Methane sulfonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane sulfonic acid has a role as an Escherichia coli metabolite.
Methane sulfonic acid is an alkanesulfonic acid and a one-carbon compound.
Methane sulfonic acid is a conjugate acid of a methanesulfonate.

An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methane sulfonic acid is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methane sulfonic acid in large quantities.
MSA undergoes biodegradation by forming CO2 and sulphate.
Methane sulfonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.

The aqueous Methane sulfonic acid solution has been considered a model electrolyte for electrochemical processes.
Poison by ingestion and intraperitoneal routes.
May be corrosive to skin, eyes, and mucous membranes.
Explosive reaction with ethyl vinyl ether.
Incompatible with hydrogen fluoride.
When heated to decomposition it emits toxic fumes of SOx.

Methane sulphonic acid, also known as methanesulfonic acid or mesylic acid.
Methane sulfonic acid is widely used as an acid catalyst and solvent in organic reactions in biological and agricultural industry.
Methane sulfonic acid is also a key ingredient in plating various metals to print circuit board manufacture in electric industry.
Besides, Methane sulfonic acid is popularly used in textile treatment, and the production of plastics and polymers.
Methane sulfonic acid is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methane sulfonic acid in large quantities.
Methane sulfonic acid undergoes biodegradation by forming CO2 and sulphate.

Methane sulfonic acid Chemical Properties
Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
Vapor density: 3.3 (vs air)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.429(lit.)
Fp: >230 °F
Storage temp.: 2-8°C
Solubility: water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
Form: Solution
Color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water.
Slightly miscible with benzene and toluene.
Immiscible with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024
Stability: Stable. Moisture sensitive.
Incompatible with amines, bases, water, common metals.
Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting).
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference: 75-75-2(CAS DataBase Reference)
NIST Chemistry Reference: CH3SO3H(75-75-2)
EPA Substance Registry System: Methane sulfonic acid (75-75-2)

Methane sulfonic acid, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.
Methane sulfonic acid has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa), the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃).
Methane sulfonic acid is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene.
Methane sulfonic acid will not subject to decomposition in boiling water and hot alkaline solution.
Methane sulfonic acid also has strong corrosion effect against the metal iron, copper and lead.

Methane sulfonic acid is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methane sulfonic acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, methane sulfonic acid is used as a starting material for the preparation of methanesulfonyl chloride.

History and Preparation / Manufacturing
The first commercial production of Methane sulfonic acid, developed in the 1940s by Standard Oil of Indiana (USA), was based on oxidation of methylsulfide by O2 from air.
Although inexpensive, this process suffered from a poor product quality and explosion hazards.

In 1967, the Pennwalt Corporation (USA) developed a different process for methylsulfide (as an water-based emulsion) oxidation using chlorine.
In 2022 this chlorine-oxidation process was used only by Arkema SA (France) for making high-purity Methane sulfonic acid.
This process is not popular on a large scale, because Methane sulfonic acid co-produces large quantities of hydrochloric acid.

Between years 1970 and 2000 Methane sulfonic acid was used only on a relatively small-scale in niche markets (e.g., in the microelectronic and electroplating industries since the 1980s), which was mainly due to its rather high price and limited availability.
However, this situation changed around 2003, when BASF launched commercial production of Methane sulfonic acid in Ludwigshafen based on a modified version of the aforementioned air oxidation process, using dimethyldisulfide instead of methylsulfide.
The former is produced in one step from methanol from syngas, hydrogen and sulfur.

An even better (lower-cost and environmentally friendlier) process of making methane sulfonic acid was developed ca. 2016 by Grillo-Werke AG (Germany).
Methane sulfonic acid is based on a direct reaction between methane and oleum at ca. 50 °C and 100 bar in the presence of a potassium persulfate initiator.

Uses
Methane sulfonic acid is a raw material for medicine and pesticide.
Methane sulfonic acid can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
Methane sulfonic acid can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry.
Methane sulfonic acid can also be applied to oxidation.
Methane sulfonic acid has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings.

One of the major advantages of methane sulfonic acid over sulfuric acid is that it is not an oxidizing species.
Methane sulfonic acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents.
Methane sulfonic acid is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters.
Methane sulfonic acid reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex.

Methane sulfonic acid finds application in batteries, because of its purity and chloride absence.
In pharmaceutical industry, Methane sulfonic acid is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan.
Methane sulfonic acid is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
Methane sulfonic acid is involved in the deprotection of peptides.
For complete protein and peptide hydrolysis with tryptophan recovery.
After hydrolysis the samples are diluted prior to amino acid analysis.

Since ca. 2000 methane sulfonic acid has become a popular replacement for other acids in numerous industrial and laboratory applications, because it is:

(1) a strong acid,
(2) has a low vapor pressure (see boiling points in the "Properties" inset),
(3) is not an oxidant or explosive, like nitric, sulfuric or perchloric acids.
(4) is liquid at room temperature,
(5) soluble in many organic solvents,
(6) forms water-soluble salts with all inorganic cations and with most organic cations,
(7) does not form complexes with metal ions in water,
(8) its anion, mesylate, is non-toxic and suitable for pharmaceutical preparations.

A the closely related p-toluenesulfonic acid (PTSA) is solid.
Methane sulfonic acid can be used in the generation of borane (BH3) by reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMSO, the complex of BH3 and the solvent is formed.

Electroplating
Solutions of methane sulfonic acid are used for the electroplating of tin and tin-lead solders.
Methane sulfonic acid is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.

Methane sulfonic acid is also a primary ingredient in rust and scale removers.
Methane sulfonic acid is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.
Methane sulfonic acid may be used:As a catalyst to produce linear alkylbenzenes by the addition reaction between long-chain olefins and benzene.
To prepare polyaniline (PANI)/graphene composites with enhanced thermal and electrical properties.
As a catalyst for the transformation of glucose/xylose mixtures to levulinic acid and furfural.

Production Method
Methane sulfonic acid can be obtained through the nitrate oxidation of thiocyanate methyl.
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃.
After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product.
The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered.
The filtrate is condensed to until crystalline precipitation.

The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate.
Methane sulfonic acid is then added to the exchanged water to boiling, add sulfuric acid for decomposition while it is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product.
Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction.

The reaction solution was extracted with chloroform.
After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure.
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride.
Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear.
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain methanesulfonic acid.

Preparation
Methane sulfonic acid is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.

Synonyms
METHANESULFONIC ACID
75-75-2
Methylsulfonic acid
Methanesulphonic acid
Methanesulfonicacid
Mesylic acid
Kyselina methansulfonova
Sulfomethane
Methansulfonsaeure
NSC 3718
METHANE SULFONIC ACID
CH3SO3H
MFCD00007518
DTXSID4026422
CHEBI:27376
22515-76-0
MSA
NSC-3718
12EH9M7279
ammoniummethanesulfonate
CCRIS 2783
Kyselina methansulfonova [Czech]
HSDB 5004
EINECS 200-898-6
CH4O3S
BRN 1446024
AI3-28532
UNII-12EH9M7279
metanesulfonic acid
methansulfonic acid
MsOH
methansulphonic acid
methylsulphonic acid
03S
methyl sulfonic acid
methyl-sulfonic acid
methane-sulfonic acid
MeSO3H
methane sulphonic acid
methanesulphonic-acid-
LACTIC ACID(DL)
ammonium methanesulphonate
CH3SO2OH
H3CSO3H
WLN: WSQ1
EC 200-898-6
Methane Sulfonic Acid 99%
Methanesulfonic acid solution
4-04-00-00010 (Beilstein Handbook Reference)
Methanesulfonic acid, 99.5%
Methanesulfonic acid, anhydrous
DTXCID806422
CHEMBL3039600
DL-MALICACIDMONOSODIUMSALT
METHANESULFONIC ACID [II]
METHANESULFONIC ACID [MI]
Methanesulfonic acid, HPLC grade
NSC3718
Methanesulfonic acid, >=99.0%
METHANESULFONIC ACID [HSDB]
Tox21_201073
STL264182
AKOS009146947
AT25153
J1.465F
CAS-75-75-2
NCGC00248914-01
NCGC00258626-01
BP-12823
DB-075013
FT-0628287
M0093
M2059
EN300-29198
Methanesulfonic acid, >=99.0%, ReagentPlus(R)
Methanesulfonic acid, for HPLC, >=99.5% (T)
A934985
Q414168
J-521696
Methanesulfonic acid, Vetec(TM) reagent grade, 98%
F1908-0093
Z281776238
METHANE SULPHONIC ACID
SYNONYMS MSA, Sulphomethane; Acide methanesulfonique;Acide methanesulfonique, Kyselina methansulfonova; Methylsulphonic acid; ácido metanosulfónico; Methansulfonsäure; cas no: 75-75-2
METHANEDICARBOXYLIC ACID (MALONIC ACID)
Methanedicarboxylic acid (Malonic Acid) has the chemical formula C3H4O4.
Methanedicarboxylic acid (Malonic Acid) appears as a white, odorless crystal or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) is soluble in Water, Ether, and Alcohol.


CAS Number: 141-82-2
EC Number: 205-503-0
MDL number: MFCD00002707
Linear Formula: CH2(COOH)2
Molecular Formula: C3H4O4 / COOHCH2COOH



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Methanedicarboxylic acid (Malonic Acid) is also known as Propanedioic acid or Dicarboxymethane.
The name is derived from the Greek word Malon which means apple.
Malonate is the ionized form of Methanedicarboxylic acid (Malonic Acid), along with its esters and salt.


Methanedicarboxylic acid (Malonic Acid) appears as a white crystal or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) dissolves in alcohol, pyridine, and ether.
Methanedicarboxylic acid (Malonic Acid) was first prepared in the year, 1858 by the French chemist Victor Dessaignes by the oxidation of malic acid.


Methanedicarboxylic acid (Malonic Acid) is found in some fruits viz citrus fruits.
Methanedicarboxylic acid (Malonic Acid) can be produced through the fermentation of glucose.
Industrially, Methanedicarboxylic acid (Malonic Acid) is produced by the hydrolysis of diethyl malonate or dimethyl malonate.


Methanedicarboxylic acid (Malonic Acid) is a forerunner to polyester specialities.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionised form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.


For example, diethyl malonate is Methanedicarboxylic acid (Malonic Acid)'s ethyl ester.
The name originates from Latin malum, meaning apple.
Methanedicarboxylic acid (Malonic Acid) is the archetypal example of a competitive inhibitor: It acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.


Methanedicarboxylic acid (Malonic Acid) has the chemical formula C3H4O4.
Methanedicarboxylic acid (Malonic Acid) appears as a white, odorless crystal or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) is soluble in Water, Ether, and Alcohol.


Upon heating to decomposition temperature, Methanedicarboxylic acid (Malonic Acid) emits irritating fumes and acrid smoke.
Methanedicarboxylic acid (Malonic Acid) acts as a precursor for conversion to 1,3-propanediol, which is a compound used in polyesters and polymers with the huge market size.


Methanedicarboxylic acid (Malonic Acid), also known as malonate or H2MALO is a dicarboxylic acid with structure CH2(COOH)2, belonging to the class of organic compounds known as dicarboxylic acids and derivatives.
These are organic compounds containing exactly two carboxylic acid groups.


The ionised form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methanedicarboxylic acid (Malonic Acid)'s ethyl ester.
The name originates from Latin malum, meaning apple.


Methanedicarboxylic acid (Malonic Acid) is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.
Methanedicarboxylic acid (Malonic Acid) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


Methanedicarboxylic acid (Malonic Acid) exists in all living species, ranging from bacteria to humans.
Within humans, Methanedicarboxylic acid (Malonic Acid) participates in a number of enzymatic reactions.
In particular, Methanedicarboxylic acid (Malonic Acid) and acetic acid can be converted into acetoacetic acid, which is mediated by the enzyme fatty acid synthase.


Beta ketoacyl synthase domain.
In addition, Methanedicarboxylic acid (Malonic Acid)d and coenzyme A can be biosynthesized from malonyl-CoA through its interaction with the enzyme fatty acid synthase. malonyl/acetyl transferase domain.


A Methanedicarboxylic acid (Malonic Acid) in which the two carboxy groups are separated by a single methylene group.
In humans, Methanedicarboxylic acid (Malonic Acid) is involved in fatty acid biosynthesis.
Outside of the human body, Methanedicarboxylic acid (Malonic Acid) has been detected, but not quantified in, several different foods, such as red beetroots, corns, scarlet beans, common beets, and cow milks.


This could make Methanedicarboxylic acid (Malonic Acid) a potential biomarker for the consumption of these foods.
Methanedicarboxylic acid (Malonic Acid), also known as malonate or H2MALO, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.


These are organic compounds containing exactly two carboxylic acid groups.
Methanedicarboxylic acid (Malonic Acid) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Methanedicarboxylic acid (Malonic Acid) exists in all living species, ranging from bacteria to humans.


Within yeast, Methanedicarboxylic acid (Malonic Acid) participates in a number of enzymatic reactions.
In particular, Methanedicarboxylic acid (Malonic Acid) and acetic acid can be converted into acetoacetic acid through the action of the enzyme fatty acid synthase.


Beta ketoacyl synthase domain.
In addition, Methanedicarboxylic acid (Malonic Acid) can be biosynthesized from malonyl-CoA through its interaction with the enzyme fatty acid synthase. malonyl/acetyl transferase domain.


In yeast, Methanedicarboxylic acid (Malonic Acid) is involved in the metabolic pathway called fatty acid biosynthesis pathway.
Methanedicarboxylic acid (Malonic Acid) has a white crystal or crystalline powder structure.
Methanedicarboxylic acid (Malonic Acid) is naturally occurring and can be found in many vegetables, fruits.


Methanedicarboxylic acid (Malonic Acid) was first prepared by Victor Dessaignes by the oxidation reaction of malic acid.
Methanedicarboxylic acid (Malonic Acid) is the second smallest aliphatic dicarboxylic acid with oxalic acid being the smallest.
Methanedicarboxylic acid (Malonic Acid) can be confused with maleic or malic acid as both contain two carboxyl groups, but it is different.


Methanedicarboxylic acid (Malonic Acid) differs from these two acids in terms of properties, structure, etc.
The name of Methanedicarboxylic acid (Malonic Acid) is derived from the Greek word Malon which means apple.
Methanedicarboxylic acid (Malonic Acid) on heating gives acetic acid.


French Chemist Victor Dessaignes was the first person to prepare this acid in 1858 by oxidation of malic acid.
Its name originated from the Greek word Malon which means Apple.
It is because Methanedicarboxylic acid (Malonic Acid) is found in some fruits.


Greater concentrations of Methanedicarboxylic acid (Malonic Acid) in citrus are found in fruits generated in organic farming compared to fruits generated in conventional farming.
Methanedicarboxylic acid (Malonic Acid) is a white crystalline substance that quickly dissolves in water and oxygenated solutions.


Methanedicarboxylic acid (Malonic Acid) has a breakdown temperature of 135 °C.
Its ionized form, esters and salts are known as malonates, such as the diethyl malonate, which is Methanedicarboxylic acid (Malonic Acid)’s diethyl ester.
The molecular weight of Methanedicarboxylic acid (Malonic Acid) is 104.061 g/mol, and its density is 1.619g/cm3.


Its melting point is 135 to 137°C and Methanedicarboxylic acid (Malonic Acid) decomposes above the boiling point of 140°C.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionised form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.


For example, diethyl malonate is Methanedicarboxylic acid (Malonic Acid)'s ethyl ester.
The name of Methanedicarboxylic acid (Malonic Acid) originates from Latin malum, meaning apple.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.


The ionized form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methanedicarboxylic acid (Malonic Acid)'s diethyl ester.
The name originates from the Greek word μᾶλον (malon) meaning 'apple'.


Methanedicarboxylic acid (Malonic Acid) appears as white crystals or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) appears as white crystals or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.


Methanedicarboxylic acid (Malonic Acid) has a role as a human metabolite.
Methanedicarboxylic acid (Malonic Acid) is an alpha,omega-dicarboxylic acid and a lipid.
Methanedicarboxylic acid (Malonic Acid) is a conjugate acid of a malonate(1-).


Methanedicarboxylic acid (Malonic Acid) is soluble in cold water.
Methanedicarboxylic acid (Malonic Acid), also known as malonate or H2MALO, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.


These are organic compounds containing exactly two carboxylic acid groups.
Methanedicarboxylic acid (Malonic Acid) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Methanedicarboxylic acid (Malonic Acid) exists in all living species, ranging from bacteria to humans.


Within yeast, Methanedicarboxylic acid (Malonic Acid) participates in a number of enzymatic reactions.
In particular, Methanedicarboxylic acid (Malonic Acid) and acetic acid can be converted into acetoacetic acid through the action of the enzyme fatty acid synthase.


Beta ketoacyl synthase domain.
In addition, Methanedicarboxylic acid (Malonic Acid) can be biosynthesized from malonyl-CoA through its interaction with the enzyme fatty acid synthase. malonyl/acetyl transferase domain.


In yeast, Methanedicarboxylic acid (Malonic Acid) is involved in the metabolic pathway called fatty acid biosynthesis pathway.
Methanedicarboxylic acid (Malonic Acid), also known as malonate or H2MALO, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.


These are organic compounds containing exactly two carboxylic acid groups.
Methanedicarboxylic acid (Malonic Acid) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Methanedicarboxylic acid (Malonic Acid) exists in all living species, ranging from bacteria to humans.


Within humans, Methanedicarboxylic acid (Malonic Acid) participates in a number of enzymatic reactions.
In particular, Methanedicarboxylic acid (Malonic Acid) and acetic acid can be converted into acetoacetic acid; which is mediated by the enzyme fatty acid synthase.


Beta ketoacyl synthase domain.
In addition, Methanedicarboxylic acid (Malonic Acid) and coenzyme A can be biosynthesized from malonyl-CoA through its interaction with the enzyme fatty acid synthase.


malonyl/acetyl transferase domain.
An Methanedicarboxylic acid (Malonic Acid) in which the two carboxy groups are separated by a single methylene group.
In humans, Methanedicarboxylic acid (Malonic Acid) is involved in fatty acid biosynthesis.


Outside of the human body, Methanedicarboxylic acid (Malonic Acid) has been detected, but not quantified in, several different foods, such as red beetroots, corns, scarlet beans, common beets, and cow milks.
This could make Methanedicarboxylic acid (Malonic Acid) a potential biomarker for the consumption of these foods.


Methanedicarboxylic acid (Malonic Acid), with regard to humans, has been found to be associated with several diseases such as eosinophilic esophagitis, combined malonic and methylmalonic aciduria, and early preeclampsia; Methanedicarboxylic acid (Malonic Acid) has also been linked to the inborn metabolic disorder malonyl-coa decarboxylase deficiency.


Methanedicarboxylic acid (Malonic Acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives.
These are organic compounds containing exactly two carboxylic acid groups.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid that forms a solid at room temperature.


Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid used as a precursor to certain polyesters and is a component in alkyd resins.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid belonging to the family of carboxylic acids.
A dicarboxylic acid contains two carboxylic acid functional groups. Usually, a dicarboxylic acid exhibits the same chemical behavior as monocarboxylic acids.


This naturally occurs in certain fruits.
Methanedicarboxylic acid (Malonic Acid) is a useful organic compound with various benefits.
Methanedicarboxylic acid (Malonic Acid)'s IUPAC name is propanedioic acid.


Methanedicarboxylic acid (Malonic Acid) should not be confused with malic or maleic acid.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with the chemical formula C3H4O4.
Dicarboxylic acids are organic compounds containing two carboxylic acid functional groups.


Methanedicarboxylic acid (Malonic Acid), Reagent is a dicarboxylic acid which name originates from the Greek work, malon, meaning apple.
Methanedicarboxylic acid (Malonic Acid) contains calcium salt in high concentrations of beetroot.
Normally Methanedicarboxylic acid (Malonic Acid) appears as white crystals.


Methanedicarboxylic acid (Malonic Acid) is an aliphatic dicarboxylic acid also referred to as propanedioic acid.
On the Kofler bench, the powdery body melts around 136°C and evaporates gradually.
Some impurities coat crystals which makes the determination of the melting point of Methanedicarboxylic acid (Malonic Acid) very imprecise.


Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
Methanedicarboxylic acid (Malonic Acid) acts as a building block in organic synthesis.


Methanedicarboxylic acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which is used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methanedicarboxylic acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.


Methanedicarboxylic acid (Malonic Acid) is soluble in cold water.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
Methanedicarboxylic acid (Malonic Acid) has three kinds of crystal forms, of which two are triclinic, and one is monoclinic.


That crystallized from ethanol is white triclinic crystals.
Methanedicarboxylic acid (Malonic Acid) decomposes to acetic acid and carbon dioxide at 140℃.
Methanedicarboxylic acid (Malonic Acid) does not decompose at 1.067×103~1.333×103Pa vacuum, but directly sublimates.


The ionised form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methanedicarboxylic acid (Malonic Acid)'s ethyl ester.
The name originates from Latin malum, meaning apple.


Methanedicarboxylic acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Methanedicarboxylic acid (Malonic Acid) has a role as a human metabolite.
Methanedicarboxylic acid (Malonic Acid) is a conjugate acid of a malonate(1-).


Methanedicarboxylic acid (Malonic Acid) is white crystals or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) sublimes in vacuum.
Methanedicarboxylic acid (Malonic Acid) is water soluble.


Methanedicarboxylic acid (Malonic Acid), also known as propanedioic acid, is a dicarboxylic acid with the chemical formula C3H4O4.
Methanedicarboxylic acid (Malonic Acid) is a white crystalline solid with a sour taste and is soluble in water and ethanol.
Methanedicarboxylic acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.


Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of Methanedicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.


Dicarboxylic acids generally show the same chemical behaviour and reactivity as monocarboxylic acids.
Methanedicarboxylic acid (Malonic Acid) is a substance found in some fruits that occurs naturally.
Fruits generated in organic farming contain greater concentrations of Methanedicarboxylic acid (Malonic Acid) in citrus compared to fruits generated in conventional farming.


The IUPAC name of Methanedicarboxylic acid (Malonic Acid) is propanedioic acid.
Methanedicarboxylic acid (Malonic Acid) is the archetypal instance of a competitive inhibitor: it functions in the respiratory electron transport chain against succinate dehydrogenase.


Methanedicarboxylic acid (Malonic Acid) is correlated with deficiency of malonyl-CoA decarboxylase, an inborn metabolism mistake.
Methanedicarboxylic acid (Malonic Acid) appears as white crystals or crystalline powder.
Methanedicarboxylic acid (Malonic Acid) sublimes in vacuum.


Methanedicarboxylic acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Methanedicarboxylic acid (Malonic Acid) has a role as a human metabolite.
Methanedicarboxylic acid (Malonic Acid) is a conjugate acid of a malonate(1-).


Methanedicarboxylic acid (Malonic Acid) is a natural product found in Camellia sinensis, Meum athamanticum, and other organisms with data available.
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of malonic acid, as well as its esters and salts, are known as malonates.


For example, diethyl malonate is malonic acid's diethyl ester.
The name of Methanedicarboxylic acid (Malonic Acid) originates from the Greek word μᾶλον (malon) meaning 'apple'.



USES and APPLICATIONS of METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a precursor to specialty polyesters.
Methanedicarboxylic acid (Malonic Acid) can be converted into 1,3-propanediol for use in polyesters and polymers (whose usefulness is unclear though).


Methanedicarboxylic acid (Malonic Acid) can also be a component in alkyd resins, which are used in a number of coatings applications for protecting against damage caused by UV light, oxidation, and corrosion.
Methanedicarboxylic acid (Malonic Acid) is used in pharmaceutical products.


One application of Methanedicarboxylic acid (Malonic Acid) is in the coatings industry as a crosslinker for low-temperature cure powder coatings, which are becoming increasingly valuable for heat sensitive substrates and a desire to speed up the coatings process.
The global coatings market for automobiles was estimated to be $18.59 billion in 2014 with projected combined annual growth rate of 5.1% through 2022.


Methanedicarboxylic acid (Malonic Acid) is used in a number of manufacturing processes as a high value specialty chemical including the electronics industry, flavors and fragrances industry, specialty solvents, polymer crosslinking, and pharmaceutical industry.
In 2004, annual global production of Methanedicarboxylic acid (Malonic Acid) and related diesters was over 20,000 metric tons.


Potential growth of these markets could result from advances in industrial biotechnology that seeks to displace petroleum-based chemicals in industrial applications.
In 2004, Methanedicarboxylic acid (Malonic Acid) was listed by the US Department of Energy as one of the top 30 chemicals to be produced from biomass.


In food and drug applications, Methanedicarboxylic acid (Malonic Acid) can be used to control acidity, either as an excipient in pharmaceutical formulation or natural preservative additive for foods.
Methanedicarboxylic acid (Malonic Acid) is used as a building block chemical to produce numerous valuable compounds, including the flavor and fragrance compounds gamma-nonalactone, cinnamic acid, and the pharmaceutical compound valproate.


Methanedicarboxylic acid (Malonic Acid) has been used to cross-link corn and potato starches to produce a biodegradable thermoplastic; the process is performed in water using non-toxic catalysts.
Starch-based polymers comprised 38% of the global biodegradable polymers market in 2014 with food packaging, foam packaging, and compost bags as the largest end-use segments.


Methanedicarboxylic acid (Malonic Acid) is used as a precursor in polymers and polyester.
Methanedicarboxylic acid (Malonic Acid) is used in flavours as well as in the fragrance industry.
Methanedicarboxylic acid (Malonic Acid) is used to control acidity.


Methanedicarboxylic acid (Malonic Acid) is used as a cross-linking agent between potato starch and cornstarch to enhance its mechanical properties.
Methanedicarboxylic acid (Malonic Acid) is used for the preparation of cinnamic acid, a compound used for the formation of cin metacin which is an anti-inflammatory.


The malonates are used in syntheses of B1 and B6, barbiturates, and several other valuable compounds.
Common Uses of Methanedicarboxylic acid (Malonic Acid): Plating agent, Surface treating agent, Intermediate, Buffer, ans Cross-linking agent.
Commercial/Industrial Applications of Methanedicarboxylic acid (Malonic Acid) :Laboratory chemicals, Pharmaceuticals, and Paint industry.


Methanedicarboxylic acid (Malonic Acid) is used in cosmetics as a buffering and as a flavouring agent in food.
Methanedicarboxylic acid (Malonic Acid) is used as a component of alkyd resins.
Methanedicarboxylic acid (Malonic Acid) is used in coating applications to protect from UV rays, oxidation, and corrosion.


Methanedicarboxylic acid (Malonic Acid) is a building block to many valuable compounds in food and drug applications, pharmaceutical, electronics industry, fragrances, specialty polymer, specialty solvents, and many more.
Methanedicarboxylic acid (Malonic Acid) is used as a cross-linking agent between cornstarch and potato starch to enhance its mechanical properties.


Methanedicarboxylic acid (Malonic Acid) is used as a precursor in polymers and polyester and is used to produce vitamin B1, vitamin B6, vitamin B2, and amino acids.
Methanedicarboxylic acid (Malonic Acid) is used in flavors as well as in the fragrance industry and electroplating.


Methanedicarboxylic acid (Malonic Acid) is also used in chemical synthesis as a building block and is used to control acidity.
Methanedicarboxylic acid (Malonic Acid) is used in pharmaceutical products and the preparation of barbituric salt.
Methanedicarboxylic acid (Malonic Acid) acts as a building block in organic synthesis.


Methanedicarboxylic acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which are used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methanedicarboxylic acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.


Methanedicarboxylic acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
Methanedicarboxylic acid (Malonic Acid) acts as a building block in organic synthesis.


Methanedicarboxylic acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which are used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methanedicarboxylic acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.


Methanedicarboxylic acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
Methanedicarboxylic acid (Malonic Acid) is used to produce an enhanced starch-based resin, which is environmentally-benign, uses water-based processing without toxic catalysts.


Methanedicarboxylic acid (Malonic Acid) is used in the synthesis of barbituric acid and its derivatives.
Methanedicarboxylic acid (Malonic Acid) was discovered and identified in 1858 from the oxidation products of apple juice.
Methanedicarboxylic acid (Malonic Acid) is present as a white crystalline powder with no odor but with a high vapor pressure at room temperature.


Methanedicarboxylic acid (Malonic Acid) is however easily soluble in water as well as in pyridine, ethanol, methanol and ether.
Methanedicarboxylic acid (Malonic Acid) is not soluble in benzene.
Methanedicarboxylic acid (Malonic Acid) is used as an intermediate in the manufacture of barbiturates and other pharmaceuticals.


Methanedicarboxylic acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
Methanedicarboxylic acid (Malonic Acid) is acts as a building block in organic synthesis.


Methanedicarboxylic acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which are used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methanedicarboxylic acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.


Methanedicarboxylic acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
This dicarboxylic acid, Methanedicarboxylic acid (Malonic Acid), finds application across various industries, including automobiles, food, fragrance, and pharmaceuticals.


Methanedicarboxylic acid (Malonic Acid) is used as a precursor in polyester and other polymers.
Methanedicarboxylic acid (Malonic Acid) is used as a flavoring agent in the fragrance industry.
Methanedicarboxylic acid (Malonic Acid) is suitable for controlling acidity.


Methanedicarboxylic acid (Malonic Acid) finds usage in pharmaceutical products.
Methanedicarboxylic acid (Malonic Acid) is used in the manufacture of biodegradable containers.
Methanedicarboxylic acid (Malonic Acid) is also a component of surgical adhesives.


Methanedicarboxylic acid (Malonic Acid) serves as a cross-linking agent between cornstarch and potato starch to enhance its properties.
Methanedicarboxylic acid (Malonic Acid) is used for the preparation of barbituric salt.
Methanedicarboxylic acid (Malonic Acid) is used in electroplating.


Methanedicarboxylic acid (Malonic Acid) is used in the production of vitamins– B1, B6, B2, and amino acids.
Methanedicarboxylic acid (Malonic Acid) can also be used as a component in alkyd resins.
Methanedicarboxylic acid (Malonic Acid) is widely used in several coating applications to protect objects against UV light damage, oxidation, and corrosion.


A common application of Methanedicarboxylic acid (Malonic Acid) is as a crosslinker for low-temperature powder coatings.
These are valuable for heat-sensitive substrates.
Methanedicarboxylic acid (Malonic Acid) is on the US Department of Energy’s list of top chemicals for biomass production.


In food and drug applications, Methanedicarboxylic acid (Malonic Acid) acts as a natural preservative additive for foods.
Its therapeutic uses include the prevention of resorption of bone tissue in broiler chicks by adding Methanedicarboxylic acid (Malonic Acid) to feed.
Methanedicarboxylic acid (Malonic Acid) is a common intermediate in the pharmaceutical industry and is frequently used in veterinary medicine.


Methanedicarboxylic acid (Malonic Acid) is also used as a flavouring agent in certain foods.
Methanedicarboxylic acid (Malonic Acid) is used to generate countless useful compounds as a construction block chemical.
Methanedicarboxylic acid (Malonic Acid) is used in the preparation of barbituric salt.


Methanedicarboxylic acid (Malonic Acid) is used in electroplating.
Methanedicarboxylic acid (Malonic Acid) is used to produce vitamin B1, vitamin B6, vitamin B2, and amino acids.
Methanedicarboxylic acid (Malonic Acid) is used in chemical synthesis as a building block.


Methanedicarboxylic acid (Malonic Acid) is a component used as a stabilizer in many high-end cosmetic and pharmaceutical products.
Methanedicarboxylic acid (Malonic Acid) is also used as building block in chemical synthesis, specifically to introduce the molecular group -CH2-COOH.
Methanedicarboxylic acid (Malonic Acid) is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation.


Methanedicarboxylic acid (Malonic Acid) is acts as a building block in organic synthesis.
Methanedicarboxylic acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which is used in coating applications, thereby protecting against UV light, corrosion and oxidation.


Methanedicarboxylic acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.
Methanedicarboxylic acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.


Methanedicarboxylic acid (Malonic Acid) is commonly used in organic synthesis, specifically in the production of pharmaceuticals, agrochemicals, and fragrances.
Methanedicarboxylic acid (Malonic Acid) is also used as a pH adjuster in the food industry.


The chemical properties of Methanedicarboxylic acid (Malonic Acid) make it a unique and versatile compound in organic chemistry.
Methanedicarboxylic acid (Malonic Acid) contains two carboxylic acid groups (-COOH) which make it a weak acid with a pKa of 2.8.
Additionally, the presence of two carbonyl groups (-C=O) make Methanedicarboxylic acid (Malonic Acid) a useful compound in organic synthesis.


Methanedicarboxylic acid (Malonic Acid) is often used as a building block in the synthesis of various organic compounds due to its ability to undergo nucleophilic substitution reactions.
Methanedicarboxylic acid (Malonic Acid) is also known for its ability to form stable complexes with metal ions.


This property is utilized in analytical chemistry for the determination of metal ions in various samples.
Methanedicarboxylic acid (Malonic Acid) can form chelates with metal ions such as calcium, magnesium, and iron, which are then easily detected and quantified.


In conclusion, Methanedicarboxylic acid (Malonic Acid) is a versatile compound with a wide range of applications in various fields.
Its unique chemical properties make Methanedicarboxylic acid (Malonic Acid) a useful building block in organic synthesis and a valuable reagent in analytical chemistry.


Methanedicarboxylic acid (Malonic Acid) is used to produce an enhanced starch-based resin, which is environmentally-benign, uses water-based processing without toxic catalysts.
Methanedicarboxylic acid (Malonic Acid) may be used as a cross-linking agent between corn starch and potato starch to improve its mechanical properties.


-Biotechnological Applications of Methanedicarboxylic acid (Malonic Acid):
The calcium salt of Methanedicarboxylic acid (Malonic Acid) occurs in high concentrations in beetroot.
Methanedicarboxylic acid (Malonic Acid) exists in its normal state as white crystals.
Methanedicarboxylic acid (Malonic Acid) is the classic example of a competitive inhibitor.
Methanedicarboxylic acid (Malonic Acid) acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.



STRUCTURE OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Malonic acid Synthesis – C3H4O4:
Preparation of Methanedicarboxylic acid (Malonic Acid) starts with chloroacetic acid which is also known as MCA (monochloroacetic acid).
Step 1: Sodium carbonate produces sodium salt.
Step 2: It is made to react with sodium cyanide.
Step 3: cyanoacetic acid salt is generated through nucleophilic substitution.
Step 4: The nitrile group is hydrolyzed with sodium hydroxide to produce sodium malonate.
Step 5: The acidification results in Methanedicarboxylic acid (Malonic Acid).



ALTERNATIVE PARENTS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
*1,3-dicarbonyl compounds
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives



SUBSTITUENTS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
*1,3-dicarbonyl compound
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



STRUCTURE AND PREPARATION OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The structure has been determined by X-ray crystallography and extensive property data including for condensed phase thermochemistry are available from the National Institute of Standards and Technology.
A classical preparation of Methanedicarboxylic acid (Malonic Acid) starts from chloroacetic acid:


*Preparation of Methanedicarboxylic acid (Malonic Acid) from chloroacetic acid.
Sodium carbonate generates the sodium salt, which is then reacted with sodium cyanide to provide the sodium salt of cyanoacetic acid via a nucleophilic substitution.

The nitrile group can be hydrolyzed with sodium hydroxide to sodium malonate, and acidification affords Methanedicarboxylic acid (Malonic Acid).
Industrially, however, Methanedicarboxylic acid (Malonic Acid) is produced by hydrolysis of dimethyl malonate or diethyl malonate.
Methanedicarboxylic acid (Malonic Acid) has also been produced through fermentation of glucose.


*Organic reactions:
Methanedicarboxylic acid (Malonic Acid) reacts as a typical carboxylic acid: forming amide, ester, anhydride, and chloride derivatives.
Malonic anhydride can be used as an intermediate to mono-ester or amide derivatives, while malonyl chloride is most useful to obtain diesters or diamides.

In a well-known reaction, Methanedicarboxylic acid (Malonic Acid) condenses with urea to form barbituric acid.
Methanedicarboxylic acid (Malonic Acid) may also be condensed with acetone to form Meldrum's acid, a versatile intermediate in further transformations.
The esters of Methanedicarboxylic acid (Malonic Acid) are also used as a −CH2COOH synthon in the malonic ester synthesis.


*Mitochondrial fatty acid synthesis:
Methanedicarboxylic acid (Malonic Acid) is the starting substrate of mitochondrial fatty acid synthesis (mtFASII), in which it is converted to malonyl-CoA by malonyl-CoA synthetase (ACSF3).

Additionally, the coenzyme A derivative of malonate, malonyl-CoA, is an important precursor in cytosolic fatty acid biosynthesis along with acetyl CoA.
Malonyl CoA is formed there from acetyl CoA by the action of acetyl-CoA carboxylase, and the malonate is transferred to an acyl carrier protein to be added to a fatty acid chain.


*Briggs–Rauscher reaction:
Methanedicarboxylic acid (Malonic Acid) is a key component in the Briggs–Rauscher reaction, the classic example of an oscillating chemical reaction.


*Knoevenagel condensation:
In Knoevenagel condensation, Methanedicarboxylic acid (Malonic Acid) or its diesters are reacted with the carbonyl group of an aldehyde or ketone, followed by a dehydration reaction.

When Methanedicarboxylic acid (Malonic Acid) itself is used, it is normally because the desired product is one in which a second step has occurred, with loss of carbon dioxide, in the so-called Doebner modification.

Thus, for example, the reaction product of acrolein and Methanedicarboxylic acid (Malonic Acid) in pyridine is trans-2,4-Pentadienoic acid with one carboxylic acid group and not two.


*Preparation of carbon suboxide:
Carbon suboxide is prepared by warming a dry mixture of phosphorus pentoxide (P4O10) and Methanedicarboxylic acid (Malonic Acid).
It reacts in a similar way to malonic anhydride, forming malonates.



FORMULA OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with the chemical formula C3H4O4 and structural formula CH2(COOH)2.
Propanedioic acid is the IUPAC name of Methanedicarboxylic acid (Malonic Acid), and another name for the acid is Methane Dicarboxylic acid.

Malonates are Methanedicarboxylic acid (Malonic Acid)'s esters and salts.
There are three carbons with four hydrogen molecules and four oxygen molecules attached.
The two OH groups are attached with two carbons



CHEMICAL PROPERTIES OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a white crystalline solid that decomposes at approximately 135°C.
Methanedicarboxylic acid (Malonic Acid) has high solubility in water and oxygenated solvents and exhibits greater acidity than acetic acid, which has a pK value of 4.75.

The pKa values for the loss of Methanedicarboxylic acid (Malonic Acid)'s first and second protons are 2.83 and 5.69, respectively.
Methanedicarboxylic acid (Malonic Acid) is slightly soluble in pyridine.
Methanedicarboxylic acid (Malonic Acid) can decompose to formic acid and carbon dioxide in case of potassium permanganate.

Since Methanedicarboxylic acid (Malonic Acid) generates carbon dioxide and water after heated without pollution problems, it can be directly used as aluminum surface treatment agent.



PREPARATION OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is usually produced from chloroacetic acid.



REACTIONS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The chloroacetic acid is added to the reaction kettle by adding sodium carbonate aqueous solution to generate sodium chloroacetate aqueous solution, and then 30% sodium cyanide solution is slowly added dropwise, and the reaction is carried out at a predetermined temperature to generate sodium cyanoacetate.
After the cyanation reaction is completed, add sodium hydroxide for heating and hydrolysis to generate sodium malonate solution, concentrate, then dropwise add sulfuric acid for acidification to generate Methanedicarboxylic acid (Malonic Acid), filter and dry to obtain the product.



PREPARATION OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
This method often does not produce a pure enough product or the pure product has an extremely low yield.
Industrially, Methanedicarboxylic acid (Malonic Acid) is also produced by hydrolyzing dimethyl malonate or diethyl malonate.
This manufacturing method is able to bring about a higher yield and purity, but the organic synthesis of Methanedicarboxylic acid (Malonic Acid) through these processes is extremely costly and environmentally hazardous.



REACTIONS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
In a well - known reaction, Methanedicarboxylic acid (Malonic Acid) condenses with urea to form barbituric acid.
Methanedicarboxylic acid (Malonic Acid) is also frequently used as an enolate in Knoevenagel condensations or condensed with acetone to form Meldrum's acid.
The esters of Methanedicarboxylic acid (Malonic Acid) are also used as a - CH2COOH synthon in the malonic ester synthesis.



BIOLOGICAL FUNCTIONS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.

Methanedicarboxylic acid (Malonic Acid) binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the CH2CH2 group required for dehydrogenation.
This observation was used to deduce the structure of the active site in succinate dehydrogenase.



REACTIVITY PROFILE OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0.
Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Methanedicarboxylic acid (Malonic Acid) to corrode or dissolve iron, steel, and aluminum parts and containers.

Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.
A wide variety of products is possible.

Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Methanedicarboxylic acid (Malonic Acid) is incompatible with strong oxidizers.
Methanedicarboxylic acid (Malonic Acid) is also incompatible with bases and reducing agents.



PURIFICATION METHODS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Crystallise Methanedicarboxylic acid (Malonic Acid) from *benzene/diethyl ether (1:1) containing 5% of pet ether (b 60-80o), wash with diethyl ether, then recrystallise it from H2O or acetone.
Dry Methanedicarboxylic acid (Malonic Acid) under vacuum over conc H2SO4.



SYNTHESIS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The synthesis of Methanedicarboxylic acid (Malonic Acid) starts with chloroacetic acid, also known as Monochloroacetic acid.
The following steps occur during the reaction:
Step 1:- Sodium salt is produced when sodium carbonate breaks down.
Step 2:- Then, the reaction of sodium salt with sodium cyanide is made to occur.
Step 3:- Through nucleophilic substitution, cyanoacetic acid salt is generated.
Step 4:- To produce sodium malonate, the nitrile group is hydrolyzed with sodium hydroxide.
Step 5:- Then the acidification yields Methanedicarboxylic acid (Malonic Acid).



REACTION OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
As with other carboxylic acids, Methanedicarboxylic acid (Malonic Acid) reacts by producing derivatives of chloride, ester, anhydride, and amide.
Malonyl chloride is best for producing diamides or diesters, although malonic anhydride can be employed as an intermediary to produce mono-ester or amide derivatives.

Barbituric acid is created when Methanedicarboxylic acid (Malonic Acid) and urea condense in a well-known process.
Additionally, acetone and propanedioic acid can be combined to generate Meldrum’s acid, a flexible intermediate used in other conversions.
Methanedicarboxylic acid (Malonic Acid) esters are also utilised in the malonic ester production as a CH2COOH synthon.

Furthermore, the coenzyme Malonyl-CoA, a malonate derivative, is the main precursor in fatty acid biosynthesis, along with acetyl CoA.
By the action of acetyl-CoA carboxylase, malonyl CoA is generated from acetyl CoA, and the malonate is transported to an acyl carrier protein to be added to a fatty acid chain.

Following are the chemical reactions that involve the Methanedicarboxylic acid (Malonic Acid):
*Briggs–Rauscher Reaction
*Knoevenagel condensation
*Preparation of carbon suboxide



IUPAC NAME OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structural formula CH2(COOH)2 and chemical formula C3H4O4.
The name Methanedicarboxylic acid (Malonic Acid) originated from the word ‘Malon’ which is Greek for ‘apple’.
The IUPAC name of Methanedicarboxylic acid (Malonic Acid) is Propanedioic acid.

Methane Dicarboxylic acid is another name for Methanedicarboxylic acid (Malonic Acid).
The ester and salts of Methanedicarboxylic acid (Malonic Acid) are called malonates.
The dicarboxylic acid has organic reactions similar to the monocarboxylic acid where amide, ester, anhydride, and chloride derivatives are formed.
Lastly, the malonic ester malonate as a coenzyme A derivative malonyl CoA that is as important a precursor as Acetyl CoA in the biosynthesis of fatty acids.



SYNTHESIS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The synthesis of Methanedicarboxylic acid (Malonic Acid) usually begins with chloroacetic acid.
Methanedicarboxylic acid (Malonic Acid) is also synthesized by cyanoacetic acid or by acid saponification reaction of malonates.
From monochloroacetic acid, Methanedicarboxylic acid (Malonic Acid) is produced by sodium or potassium cyanide.

The sodium carbonate primarily breaks down to give sodium salt which reacts with sodium cyanide to give sodium salt of cyanoacetic acid by the process of nucleophilic substitution.
Further, via hydrolyzation, the nitrile group binds with sodium malonate, whose acidification results in the production of Methanedicarboxylic acid (Malonic Acid).



STRUCTURAL FORMULA OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The structural formula of Methanedicarboxylic acid (Malonic Acid) can be given as:
The Methanedicarboxylic acid (Malonic Acid) Lewis structure has been found by the X-ray crystallography method.
The Methanedicarboxylic acid (Malonic Acid) structure CH2(COOH)2 has two carboxylic acids.
The salts and esters of malonic acid (malonates) have structures similar to Methanedicarboxylic acid (Malonic Acid).



PROPERTIES OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) molecular weight: 104.061 g.mol-1
The density of Methanedicarboxylic acid (Malonic Acid) is 1.619 g/cm3.
Methanedicarboxylic acid (Malonic Acid) appears as a crystalline powder that is white or colourless.

At the boiling point above 140oC Methanedicarboxylic acid (Malonic Acid) decomposes.
The melting point of Methanedicarboxylic acid (Malonic Acid) is 135-137o C.
If heated to decomposition under fire Methanedicarboxylic acid (Malonic Acid) emits carbon oxide fumes and acrid irritating smoke.

Acidity pKa = 2.85 at 25oC.
pKa1 = 2.83, pKa2 = 5.69
The molar heat of combustion of Methanedicarboxylic acid (Malonic Acid) is 864 kJ/mol.

The heat of vaporization of Methanedicarboxylic acid (Malonic Acid) is 92 kJ/mol.
Methanedicarboxylic acid (Malonic Acid) is soluble in water.
Solubility of Methanedicarboxylic acid (Malonic Acid) is 763 g/L.



POLARITY AND SOLUBILITY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a dicarboxylic acid belonging to the family of carboxylic acids.
A dicarboxylic acid contains two carboxylic acid functional groups.
Usually, a dicarboxylic acid exhibits the same chemical behavior as monocarboxylic acids.

This naturally occurs in certain fruits.
Methanedicarboxylic acid (Malonic Acid) is a useful organic compound with various benefits.
Methanedicarboxylic acid (Malonic Acid)'s IUPAC name is propanedioic acid.

Methanedicarboxylic acid (Malonic Acid) should not be confused with malic or maleic acid.
Methanedicarboxylic acid (Malonic Acid) is an organic compound naturally found in some fruits.
Fruits produced in organic farming have greater concentrations of Methanedicarboxylic acid (Malonic Acid) than those generated from conventional farming practices.

Methanedicarboxylic acid (Malonic Acid) is often found in some citrus fruits and vegetables.
Methanedicarboxylic acid (Malonic Acid) is a component of food items, it is present in animals, including humans.



POLARITY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Carboxyl group is polar as there is a large difference in the electronegativity values of oxygen and hydrogen.
Methanedicarboxylic acid (Malonic Acid) has two carboxyl groups and only three carbon atoms, which has little effect on polarity, so the malonic acid molecule is polar.



SOLUBILITY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Sample of Methanedicarboxylic acid (Malonic Acid) was tested with water, methyl alcohol, and hexane.
Methanedicarboxylic acid (Malonic Acid) was soluble in water because both malonic acid and water are polar.
Methanedicarboxylic acid (Malonic Acid) took 25 seconds for malonic acid to dissolve in water.

Methanedicarboxylic acid (Malonic Acid) was soluble in methyl alcohol because malonic acid is polar and methyl alcohol is intermediately polar, allowing malonic acid to dissolve in the methanol in 15 seconds.
Methanedicarboxylic acid (Malonic Acid) was insoluble in hexane because hexane is nonpolar while malonic acid is polar.



HISTORY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is a naturally occurring substance found in many fruits and vegetables.
There is a suggestion that citrus fruits produced in organic farming contain higher levels of Methanedicarboxylic acid (Malonic Acid) than fruits produced in conventional agriculture.
Methanedicarboxylic acid (Malonic Acid) was first prepared in 1858 by the French chemist Victor Dessaignes via the oxidation of malic acid.



PATHOLOGY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
If elevated Methanedicarboxylic acid (Malonic Acid) levels are accompanied by elevated methylmalonic acid levels, this may indicate the metabolic disease combined malonic and methylmalonic aciduria (CMAMMA).
By calculating the Methanedicarboxylic acid (Malonic Acid) to methylmalonic acid ratio in blood plasma, CMAMMA can be distinguished from classic methylmalonic acidemia.



BIOCHEMISTRY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.

Methanedicarboxylic acid (Malonic Acid) binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the −CH2CH2− group required for dehydrogenation.

This observation was used to deduce the structure of the active site in succinate dehydrogenase.
Inhibition of this enzyme decreases cellular respiration.
Since Methanedicarboxylic acid (Malonic Acid) is a natural component of many foods, it is present in mammals including humans.



RELATED CHEMICALS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The fluorinated version of Methanedicarboxylic acid (Malonic Acid) is difluoromalonic acid
Methanedicarboxylic acid (Malonic Acid) is diprotic; that is, it can donate two protons per molecule.
Methanedicarboxylic acid (Malonic Acid)'s first is 2.8 and the second is 5.7.

Thus the malonate ion can be HOOCCH2COO− or CH2(COO)2−2.
Malonate or propanedioate compounds include salts and esters of Methanedicarboxylic acid (Malonic Acid), such as Diethyl malonate, Dimethyl malonate, Disodium malonate, and Malonyl-CoA.



CALCULATION OF MOLECULAR WEIGHT OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The formula of malonic acid is C3H4O4.
The atomic weight of carbon is 12.011.
The atomic weight of oxygen is 15.999.
The atomic weight of hydrogen is 1.00784.

So, its molar mass can be calculated as follows:
= (3 × 12.011) + (4 × 1.00784) + (4 × 15.999)
= 36.033 + 4. 03136 + 63.996
= 104.06 grams/ mol
Thus, the molar mass or molecular weight of Methanedicarboxylic acid (Malonic Acid) is 104.061 g/mol.



CHEMICAL PROPERTIES OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The chemical properties of Methanedicarboxylic acid (Malonic Acid) are as follows:

*On Heating:
When It is heated, Methanedicarboxylic acid (Malonic Acid) gives acetic acid and carbon dioxide.


*Reaction with Phosphorus Pentoxide:
On heating a dry mixture of Methanedicarboxylic acid (Malonic Acid) and phosphorus pentoxide, carbon suboxide is prepared.


*Decomposition:
Methanedicarboxylic acid (Malonic Acid) has hazardous decomposition products under fire conditions, including carbon oxides.
Also, when heated, Methanedicarboxylic acid (Malonic Acid) decomposes and emits acrid smoke in addition to irritating fumes.


*Organic Reactions:
Methanedicarboxylic acid (Malonic Acid) reactions are usually similar to a typical carboxylic acid.
Methanedicarboxylic acid (Malonic Acid) forms amide, anhydrides, esters, and chloride derivatives on reacting with specific reactants.

Malonic anhydride serves as an intermediate in the formation of amide derivatives.
Malonyl chloride is widely used for obtaining diamides or diesters.
Some of the popular organic reactions involving Methanedicarboxylic acid (Malonic Acid) are as follows:

Methanedicarboxylic acid (Malonic Acid) condenses with urea to give barbituric acid.
Methanedicarboxylic acid (Malonic Acid) also condenses with acetone to produce Meldrum’s acid.
Methanedicarboxylic acid (Malonic Acid) is a versatile intermediate and helps in further transformations.

Malonate’s coenzyme A derivative— malonyl-CoA, acts as an important precursor in fatty acid biosynthesis.
Methanedicarboxylic acid (Malonic Acid) is formed from acetyl CoA when it is acted upon by acetyl-CoA carboxylase.
The malonate gets transferred to an acyl carrier protein for its addition to the fatty acid chain.


*Briggs–Rauscher Reaction:
A popular name reaction has Methanedicarboxylic acid (Malonic Acid) as its key component.
Methanedicarboxylic acid (Malonic Acid) is an example of an oscillating chemical reaction.


*Knoevenagel Condensation:
The reaction is a modification of the aldol condensation reaction (the reaction between benzaldehyde and acetophenone).
Methanedicarboxylic acid (Malonic Acid) involves the interaction of malonic acid or its diesters with the carbonyl group of a ketone or an aldehyde.
This process is followed by a dehydration reaction.



BIOCHEMISTRY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The calcium salt of Methanedicarboxylic acid (Malonic Acid) occurs in high concentrations in beetroot.
Methanedicarboxylic acid (Malonic Acid) exists in its normal state as white crystals.



ORGANIC SYNTHESIS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
A classical preparation of Methanedicarboxylic acid (Malonic Acid) starts from acetic acid.
Methanedicarboxylic acid (Malonic Acid) is chlorinated to chloroacetic acid.
Sodium carbonate generates the sodium salt which is then reacted with sodium cyanide to the cyano acetic acid salt in a nucleophilic substitution.
The nitrile group can be hydrolysed with sodium hydroxide to sodium malonate and acidification affords Methanedicarboxylic acid (Malonic Acid).



ORGANIC REACTIOS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
In a well known reaction Methanedicarboxylic acid (Malonic Acid) condenses with urea to barbituric acid.
Methanedicarboxylic acid (Malonic Acid) is frequently used as an enolate in Knoevenagel condensations or condensed with acetone to form Meldrum's acid.
Methanedicarboxylic acid (Malonic Acid)'s esters are also used for the -CH2COOH synthon in the malonic ester synthesis.



OCCURRENCE OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is an organic compound naturally found in some fruits.
Fruits produced in organic farming have greater concentrations of Methanedicarboxylic acid (Malonic Acid) than those generated from conventional farming practices.

Methanedicarboxylic acid (Malonic Acid) is often found in some citrus fruits and vegetables.
Methanedicarboxylic acid (Malonic Acid) is a component of food items, it is present in animals, including humans.
The name of Methanedicarboxylic acid (Malonic Acid) is derived from the Greek word Malon.

It means apple.
The ionized form of Methanedicarboxylic acid (Malonic Acid) is malonate, along with its salts and esters.
Methanedicarboxylic acid (Malonic Acid) occurs as a white crystal or crystalline powder in nature.



DID YOU KNOW:
Several food substances contain Methanedicarboxylic acid (Malonic Acid), including:
● Red beetroots
● Corns
● Common beets
● Scarlet beans
● Cow’s milk
Its occurrence in food items makes Methanedicarboxylic acid (Malonic Acid) a potential biomarker indicating the consumption of these foods.



HISTORY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
In 1858, Methanedicarboxylic acid (Malonic Acid) was prepared for the first time by a French chemist –Victor Dessaignes.
He oxidized malic acid with potassium dichromate, which is a strong oxidizing agent.
Later Methanedicarboxylic acid (Malonic Acid) was found to occur in some fruits viz citrus fruits.
Methanedicarboxylic acid (Malonic Acid) can also be produced by fermenting glucose.



SIGNIFICANCE OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) is an example of a competitive inhibitor.
Methanedicarboxylic acid (Malonic Acid) functions in the ETS chain against succinate dehydrogenase in respiration.

Methanedicarboxylic acid (Malonic Acid) is related to a deficiency of malonyl-CoA decarboxylase that leads to an inborn metabolism mistake.
It serves as a potential biomarker for tracking foods that contain Methanedicarboxylic acid (Malonic Acid).
Methanedicarboxylic acid (Malonic Acid) finds usage in various industries.



FORMULA OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The Methanedicarboxylic acid (Malonic Acid) formula is C3H4O4.
Methanedicarboxylic acid (Malonic Acid) is also called propanedioic acid or dicarboxymethane, and the formula is written as CH₂(COOH)₂.

So, the names of C3H4O4 are as follows:
*Malonic acid
*Propanedioic acid
*Carboxy Acetic acid
*Dicarboxymethane
*Methane dicarboxylic acid
*Dicarboxylate
*Dicarboxylic acid
*1,3-Propanedioic acid
*Methane dicarbonic acid
*Propane-1,3-dioic acid



STRUCTURE OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The structure of Methanedicarboxylic acid (Malonic Acid) is as follows:
*Methanedicarboxylic acid (Malonic Acid) is diprotic.
*Methanedicarboxylic acid (Malonic Acid) can donate two protons per molecule.



CHEMICALS CLOSELY RELATED TO METHANEDICARBOXYLIC ACID (MALONIC ACID):
● Difluoro Malonic acid:
It is the fluorinated version of Methanedicarboxylic acid (Malonic Acid).

● Malonate includes esters and salts of malonic acids, such as:
*Disodium malonate
*Diethyl malonate
*Malonyl-CoA
*Dimethyl malonate



PREPARATION OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic acid (Malonic Acid) can be prepared with chloroacetic acid (also called mono chloroacetic acid).
Sodium carbonate gives sodium salt.
The salt reacts with sodium cyanide.

Nucleophilic substitution reaction gives rise to cyanoacetic acid salt.
The nitrile group is hydrolyzed with NaOH to produce sodium malonate.
The acidification of sodium malonate gives Methanedicarboxylic acid (Malonic Acid).

*Industrial Preparation:
Methanedicarboxylic acid (Malonic Acid) can also be produced by hydrolyzing diethyl malonate or dimethyl malonate.



PHYSICAL and CHEMICAL PROPERTIES of METHANEDICARBOXYLIC ACID (MALONIC ACID):
Physical Appearance: A solid
Storage: Store at -20°C
M.Wt: 104.06
Cas No.: 141-82-2
Formula: C3H4O4
Solubility: ≥10.4 mg/mL in DMSO; ≥104 mg/mL in H2O; ≥119.8 mg/mL in EtOH
Chemical Name: malonic acid
Canonical SMILES: O=C(O)CC(O)=O
Shipping Condition: Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
CAS Number: 141-82-2
Molecular Weight: 104.06
Beilstein: 1751370
MDL number: MFCD00002707
Molecular Weight: 104.06 g/mol
XLogP3: -0.8
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2

Exact Mass: 104.01095860 g/mol
Monoisotopic Mass: 104.01095860 g/mol
Topological Polar Surface Area: 74.6Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 83.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: powder
Color: white
Odor: odorless

Melting point/freezing point:
Melting point: >= 135 °C
Initial boiling point and boiling range: 215 °C at 18,66 hPa (decomposition)
Flammability (solid, gas): The product is not flammable.
Upper/lower flammability or explosive limits: No data available
Flash point: 157 °C - c.c.
Autoignition temperature: No data available
Decomposition temperature: > 140 °C
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility 766 g/l at 20 °C

Partition coefficient:
n-octanol/water:
log Pow: -0,81 - Bioaccumulation is not expected.
Vapor pressure: 0,002 hPa at 25 °C
Density: 1,6 g/cm3
Relative density: 1,03 at 20 °C
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
CAS Number: 141-82-2
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7) check
Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
InChI=1/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
Key: OFOBLEOULBTSOW-UHFFFAOYAJ

SMILES: O=C(O)CC(O)=O
C(C(=O)O)C(=O)O
Chemical formula: C3H4O4
Molar mass: 104.061 g·mol−1
Density: 1.619 g/cm3
Melting point: 135 to 137 °C (275 to 279 °F; 408 to 410 K) (decomposes)
Boiling point: decomposes
Solubility in water: 763 g/L
Acidity (pKa): pKa1 = 2.83
pKa2 = 5.69
Magnetic susceptibility (χ): -46.3·10−6 cm3/mol
Chemical Formula: C3H4O4
Average Molecular Weight: 104.0615
Monoisotopic Molecular Weight: 104.010958616
IUPAC Name: propanedioic acid
Traditional Name: malonic acid

CAS Registry Number: 141-82-2
SMILES: OC(=O)CC(O)=O
InChI Identifier: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
InChI Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
Molecular Weight: 104.06100
Exact Mass: 104.06
EC Number: 205-503-0
UNII: 9KX7ZMG0MK
ICSC Number: 1085
NSC Number: 8124
DSSTox ID: DTXSID7021659
Color/Form: White crystals|Crystalline powder
Colorless hygroscopic solid which sublimes in vacuum
HScode: 2917190090
PSA: 74.60000
XLogP3: -0.8
Appearance: Malonic acid appears as white crystals or crystalline powder.
Sublimes in vacuum.

Density: 1.6 g/cm3
Melting Point: 135 °C (decomp)
Boiling Point: 215 °C @ Press: 14 Torr
Flash Point: 201.9ºC
Refractive Index: 1.479
Water Solubility: H2O: 1400 g/L (20 ºC)
Storage Conditions: Store at RT.
Vapor Pressure: 4.66E-07mmHg at 25°C
PKA: 2.85(at 25 °C)
Dissociation Constants: 2.85 (at 25 °C)|pKa1 = 2.8, pKa2 = 5.7 at 25 °C
Experimental Properties:
Enthalpy of Sublimation: 72.7 kJ/mol at 306 deg K, 108.0 kJ/mol at 348 deg K

Henry's Law constant = 4.8X10-13 atm-cu m/mole at 23 °C
(estimated from vapor pressure and water solubility)
Hydroxyl radical reaction rate constant = 1.6X10-12 cu-cm/molc sec at 25 °C (est)
Air and Water Reactions: Water soluble.
Reactive Group: Acids, Carboxylic
Heat of Combustion: Molar heat of combustion: 864 kJ/mol
Heat of Vaporization: 92 kJ/mol
Critical Temperature & Pressure:
Critical temperature: 805 K (estimated);
critical pressure: 5640 kPa (estimated)
CAS: 141-82-2
Molecular Formula: C3H4O4
Molecular weight: 104.06
EINECS: 205-503-0

Purity: ≥99%
Appearance: White crystal powder
Melting point: 132-135 °C (dec.) (lit.)
Boiling point: 140ºC(decomposition)
Density: 1.619 g/cm3 at 25 °C
Refractive index: 1.478
Flash Point: 157°C
Storage condition: Sealed in dry,Room Temperature
Solubility : 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
Pka: 2.83(at 25ºC)
Stability: Stable.
Incompatible with oxidizing agents, reducing agents, bases.
HS Code: 29171910

PH: 3.17(1 mM solution);2.5(10 mM solution);
1.94(100 mM solution)
MDL: MFCD00002707
Water Solubility: 1400 g/L (20 ºC)
Vapor Presure: 0-0.2Pa at 25ºC
Physical and Chemical Properties:
Character: white crystal.
soluble in water, soluble in ethanol and ether, pyridine.
Color: White
Formula Weight: 104.1
Percent Purity: 0.99
Physical Form: Powder
Chemical Name or Material: Malonic acid
Melting point: 132-135 °C (dec.) (lit.)
Boiling point: 140℃(decomposition)

Density: 1.619 g/cm3 at 25 °C
vapor pressure: 0-0.2Pa at 25℃
refractive index: 1.4780
Flash point: 157°C
storage temp.: Sealed in dry,Room Temperature
solubility: 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
form: Liquid
pka: 2.83(at 25℃)
color: White
PH: 3.17(1 mM solution);2.5(10 mM solution);1.94(100 mM solution)
Water Solubility: 1400 g/L (20 ºC)
Merck: 14,5710
BRN: 1751370
Stability: Stable.
Incompatible with oxidizing agents, reducing agents, bases.
InChIKey: OFOBLEOULBTSOW-UHFFFAOYSA-N

LogP: -0.81
CAS DataBase Reference: 141-82-2(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 9KX7ZMG0MK
NIST Chemistry Reference: Malonic acid(141-82-2)
EPA Substance Registry System: Propanedioic acid (141-82-2)
Molecular Weight: 104.06 g/mol
XLogP3: -0.8
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 104.01095860 g/mol
Monoisotopic Mass: 104.01095860 g/mol
Topological Polar Surface Area: 74.6Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 83.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0

Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical formula: C3H4O4
Molar mass: 104.061 g·mol−1
Density: 1.619 g/cm3
Melting point: 135 to 137 °C (275 to 279 °F; 408 to 410 K) (decomposes)
Boiling point: decomposes
Solubility in water: 763 g/L
Acidity (pKa): pKa1 = 2.83
pKa2 = 5.69
Magnetic susceptibility (χ): -46.3·10−6 cm3/mol
Solubility: Dissolves in alcohol, pyridine, and ether.
Molecular Wt/ Molar Mass: 104.06 g/mol

Density: 1.619 g/cm³
Boiling Point: Decomposes
Melting Point: 135 to 137°C
Nature: Acidic
Color: White
Stability: Usually stable under recommended conditions
Molar heat of combustion: 864 kJ/mol
The heat of vaporization: 92 kJ/mol
It does not have a chiral center.
So, it doesn’t exhibit optical isomerism.
It is a hygroscopic solid that sublimes in a vacuum.
Chemical Formula: C3H4O4
Average Molecular Weight: 104.0615
Monoisotopic Molecular Weight: 104.010958616
IUPAC Name: propanedioic acid
Traditional Name: malonic acid

CAS Registry Number: 141-82-2
SMILES: OC(=O)CC(O)=O
InChI Identifier: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
InChI Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
CAS number: 141-82-2
Weight Average: 104.0615
Monoisotopic: 104.010958616
InChI Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
IUPAC Name: propanedioic acid
Traditional IUPAC Name: malonic acid
Chemical Formula: C3H4O4
SMILES: OC(=O)CC(O)=O
Water Solubility: 197 g/L
logP: -0.6
logP: -0.33
logS: 0.28
pKa (Strongest Acidic): 2.43
Physiological Charge: -2

Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 2
Polar Surface Area: 74.6 Ų
Rotatable Bond Count: 2
Refractivity: 18.99 m³·mol⁻¹
Polarizability: 8.13 ų
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: Yes
Melting point: 132-135 °C (dec.) (lit.)
Boiling point: 140℃(decomposition)
Density: 1.619 g/cm3 at 25 °C
vapor pressure: 0-0.2Pa at 25℃
refractive index: 1.4780
Flash point: 157°C
storage temp.: Sealed in dry,Room Temperature

solubility: 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
form: Liquid
pka: 2.83(at 25℃)
color: White
PH: 3.17(1 mM solution);2.5(10 mM solution);1.94(100 mM solution)
Water Solubility: 1400 g/L (20 ºC)
Merck: 14,5710
BRN: 1751370
Stability: Stable.
Incompatible with oxidizing agents, reducing agents, bases.
InChIKey: OFOBLEOULBTSOW-UHFFFAOYSA-N
LogP: -0.81
CAS DataBase Reference 141-82-2(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 9KX7ZMG0MK
NIST Chemistry Reference: Malonic acid(141-82-2)
EPA Substance Registry System: Propanedioic acid (141-82-2)

Physical Appearance: A solid
Storage: Store at -20°C
M.Wt: 104.06
Cas No.: 141-82-2
Formula: C3H4O4
Solubility: ≥10.4 mg/mL in DMSO; ≥104 mg/mL in H2O; ≥119.8 mg/mL in EtOH
Chemical Name: malonic acid
Canonical SMILES: O=C(O)CC(O)=O
Shipping Condition: Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
CAS Number: 141-82-2
Molecular Weight: 104.06
Beilstein: 1751370
MDL number: MFCD00002707
Molecular Weight: 104.06 g/mol
XLogP3: -0.8
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2



FIRST AID MEASURES of METHANEDICARBOXYLIC ACID (MALONIC ACID):
-Description of first-aid measures
*General advice
Show this material safety data sheet to the doctor in attendance.
*If inhaled
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed
No data available



ACCIDENTAL RELEASE MEASURES of METHANEDICARBOXYLIC ACID (MALONIC ACID):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of METHANEDICARBOXYLIC ACID (MALONIC ACID):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of METHANEDICARBOXYLIC ACID (MALONIC ACID):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of METHANEDICARBOXYLIC ACID (MALONIC ACID):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
*Storage class:
Storage class (TRGS 510): 13:
Non Combustible Solids



STABILITY and REACTIVITY of METHANEDICARBOXYLIC ACID (MALONIC ACID):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .


METHANEDICARBOXYLIC ACID (MALONIC ACID)
DESCRIPTION:
Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of Methanedicarboxylic Acid (Malonic Acid), as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acid's diethyl ester.
The name originates from the Greek word μᾶλον (malon) meaning 'apple'.


CAS Number: 141-82-2
European Community (EC) Number: 205-503-0
IUPAC Name: propanedioic acid
Molecular Formula: C3H4O4


Methanedicarboxylic Acid (Malonic Acid), also known as propanedioic acid, is a dicarboxylic acid with structure CH2(COOH)2.
Methanedicarboxylic Acid (Malonic Acid) have three kinds of crystal forms, of which two are triclinic, and one is monoclinic.
That crystallized from ethanol is white triclinic crystals.
It decomposes to acetic acid and carbon dioxide at 140℃.


Methanedicarboxylic Acid (Malonic Acid) does not decompose at 1.067×103~1.333×103Pa vacuum, but directly sublimates.
The ionised form of malonic acid, as well as its esters and salts, are known as malonates.
For example, diethyl malonate is malonic acid's ethyl ester.
The name originates from Latin malum, meaning apple.


Methanedicarboxylic Acid (Malonic Acid) is a dicarboxylic acid belonging to the family of carboxylic acids.
A dicarboxylic acid contains two carboxylic acid functional groups.
Usually, a dicarboxylic acid exhibits the same chemical behavior as monocarboxylic acids.

Methanedicarboxylic Acid (Malonic Acid) naturally occurs in certain fruits.
Methanedicarboxylic Acid (Malonic Acid) is a useful organic compound with various benefits.
Its IUPAC name is propanedioic acid.
Methanedicarboxylic Acid (Malonic Acid) should not be confused with malic or maleic acid.



OCCURRENCE OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic Acid (Malonic Acid) is an organic compound naturally found in some fruits.
Fruits produced in organic farming have greater concentrations of malonic acid than those generated from conventional farming practices.
Methanedicarboxylic Acid (Malonic Acid) is often found in some citrus fruits and vegetables.

Methanedicarboxylic Acid (Malonic Acid) is a component of food items, it is present in animals, including humans.
The name of this acid is derived from the Greek word Malon.

It means apple.
The ionized form of malonic acid is malonate, along with its salts and esters.
Methanedicarboxylic Acid (Malonic Acid) occurs as a white crystal or crystalline powder in nature.



HISTORY OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic Acid (Malonic Acid) is a naturally occurring substance found in many fruits and vegetables.
There is a suggestion that citrus fruits produced in organic farming contain higher levels of malonic acid than fruits produced in conventional agriculture.
Methanedicarboxylic Acid (Malonic Acid) was first prepared in 1858 by the French chemist Victor Dessaignes via the oxidation of malic acid.


In 1858, Methanedicarboxylic Acid (Malonic Acid) was prepared for the first time by a French chemist –Victor Dessaignes.
He oxidized malic acid with potassium dichromate, which is a strong oxidizing agent.
Later Methanedicarboxylic Acid (Malonic Acid) was found to occur in some fruits viz citrus fruits.
Methanedicarboxylic Acid (Malonic Acid) can also be produced by fermenting glucose.


SIGNIFICANCE OF MALONIC ACID:
Methanedicarboxylic Acid (Malonic Acid) is an example of a competitive inhibitor.
Methanedicarboxylic Acid (Malonic Acid) functions in the ETS chain against succinate dehydrogenase in respiration.
Methanedicarboxylic Acid (Malonic Acid) is related to a deficiency of malonyl-CoA decarboxylase that leads to an inborn metabolism mistake.

Methanedicarboxylic Acid (Malonic Acid) serves as a potential biomarker for tracking foods that contain malonic acids.
Methanedicarboxylic Acid (Malonic Acid) finds usage in various industries.


METHANEDICARBOXYLIC ACID (MALONIC ACID) FORMULA:
The Methanedicarboxylic Acid (Malonic Acid) formula is C3H4O4.
Methanedicarboxylic Acid (Malonic Acid) is also called propanedioic acid or dicarboxymethane, and the formula is written as CH₂(COOH)₂.

So, the names of C3H4O4 are as follows:
• Malonic acid
• Propanedioic acid
• Carboxy Acetic acid
• Dicarboxymethane
• Methane dicarboxylic acid
• Dicarboxylate
• Dicarboxylic acid
• 1,3-Propanedioic acid
• Methane dicarbonic acid
• Propane-1,3-dioic acid

Chemicals Closely Related to Malonic Acid:
● Difluoro Malonic acid: It is the fluorinated version of malonic acid.
● Malonate includes esters and salts of malonic acids, such as:
• Disodium malonate
• Diethyl malonate
• Malonyl-CoA
• Dimethyl malonate


STRUCTURE AND PREPARATION OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
The structure has been determined by X-ray crystallography and extensive property data including for condensed phase thermochemistry are available from the National Institute of Standards and Technology.

A classical preparation of malonic acid starts from chloroacetic acid:
Sodium carbonate generates the sodium salt, which is then reacted with sodium cyanide to provide the sodium salt of cyanoacetic acid via a nucleophilic substitution.
The nitrile group can be hydrolyzed with sodium hydroxide to sodium malonate, and acidification affords malonic acid.

Industrially, however, malonic acid is produced by hydrolysis of dimethyl malonate or diethyl malonate.
It has also been produced through fermentation of glucose.

It can be prepared with chloroacetic acid (also called mono chloroacetic acid).
Sodium carbonate gives sodium salt.
The salt reacts with sodium cyanide.


Nucleophilic substitution reaction gives rise to cyanoacetic acid salt.
The nitrile group is hydrolyzed with NaOH to produce sodium malonate.
The acidification of sodium malonate gives malonic acid.





ORGANIC REACTIONS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Malonic acid reacts as a typical carboxylic acid: forming amide, ester, anhydride, and chloride derivatives.
Malonic anhydride can be used as an intermediate to mono-ester or amide derivatives, while malonyl chloride is most useful to obtain diesters or diamides.
In a well-known reaction, malonic acid condenses with urea to form barbituric acid.

Methanedicarboxylic Acid (Malonic Acid) may also be condensed with acetone to form Meldrum's acid, a versatile intermediate in further transformations.
The esters of malonic acid are also used as a −CH2COOH synthon in the malonic ester synthesis.


MITOCHONDRIAL FATTY ACID SYNTHESIS:
Malonic acid is the starting substrate of mitochondrial fatty acid synthesis (mtFASII), in which it is converted to malonyl-CoA by malonyl-CoA synthetase (ACSF3).
Additionally, the coenzyme A derivative of malonate, malonyl-CoA, is an important precursor in cytosolic fatty acid biosynthesis along with acetyl CoA.

Malonyl CoA is formed there from acetyl CoA by the action of acetyl-CoA carboxylase, and the malonate is transferred to an acyl carrier protein to be added to a fatty acid chain.


Briggs–Rauscher reaction:
Malonic acid is a key component in the Briggs–Rauscher reaction, the classic example of an oscillating chemical reaction.


Knoevenagel condensation:
In Knoevenagel condensation, malonic acid or its diesters are reacted with the carbonyl group of an aldehyde or ketone, followed by a dehydration reaction.
Z=COOH (malonic acid) or Z=COOR' (malonate ester)

When malonic acid itself is used, it is normally because the desired product is one in which a second step has occurred, with loss of carbon dioxide, in the so-called Doebner modification.
The Doebner modification of the Knoevenagel condensation.
Thus, for example, the reaction product of acrolein and malonic acid in pyridine is trans-2,4-Pentadienoic acid with one carboxylic acid group and not two.

Preparation of carbon suboxide:
Carbon suboxide is prepared by warming a dry mixture of phosphorus pentoxide (P4O10) and malonic acid.
It reacts in a similar way to malonic anhydride, forming malonates.


APPLICATIONS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Methanedicarboxylic Acid (Malonic Acid) is a precursor to specialty polyesters.
Methanedicarboxylic Acid (Malonic Acid) can be converted into 1,3-propanediol for use in polyesters and polymers (whose usefulness is unclear though).
Methanedicarboxylic Acid (Malonic Acid) can also be a component in alkyd resins, which are used in a number of coatings applications for protecting against damage caused by UV light, oxidation, and corrosion.


One application of Methanedicarboxylic Acid (Malonic Acid) is in the coatings industry as a crosslinker for low-temperature cure powder coatings, which are becoming increasingly valuable for heat sensitive substrates and a desire to speed up the coatings process.
The global coatings market for automobiles was estimated to be $18.59 billion in 2014 with projected combined annual growth rate of 5.1% through 2022.


Methanedicarboxylic Acid (Malonic Acid) is used in a number of manufacturing processes as a high value specialty chemical including the electronics industry, flavors and fragrances industry, specialty solvents, polymer crosslinking, and pharmaceutical industry.
In 2004, annual global production of malonic acid and related diesters was over 20,000 metric tons.
Potential growth of these markets could result from advances in industrial biotechnology that seeks to displace petroleum-based chemicals in industrial applications.


In 2004, Methanedicarboxylic Acid (Malonic Acid) was listed by the US Department of Energy as one of the top 30 chemicals to be produced from biomass.
In food and drug applications, malonic acid can be used to control acidity, either as an excipient in pharmaceutical formulation or natural preservative additive for foods.
Methanedicarboxylic Acid (Malonic Acid) is used as a building block chemical to produce numerous valuable compounds, including the flavor and fragrance compounds gamma-nonalactone, cinnamic acid, and the pharmaceutical compound valproate.

Malonic acid (up to 37.5% w/w) has been used to cross-link corn and potato starches to produce a biodegradable thermoplastic; the process is performed in water using non-toxic catalysts.
Starch-based polymers comprised 38% of the global biodegradable polymers market in 2014 with food packaging, foam packaging, and compost bags as the largest end-use segments.
Eastman Kodak company and others use malonic acid and derivatives as a surgical adhesive.



Pathology:
If elevated malonic acid levels are accompanied by elevated methylmalonic acid levels, this may indicate the metabolic disease combined malonic and methylmalonic aciduria (CMAMMA).
By calculating the malonic acid to methylmalonic acid ratio in blood plasma, CMAMMA can be distinguished from classic methylmalonic acidemia.


Biochemistry:
Malonic acid is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.
It binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the −CH2CH2− group required for dehydrogenation.
This observation was used to deduce the structure of the active site in succinate dehydrogenase. Inhibition of this enzyme decreases cellular respiration.

Since malonic acid is a natural component of many foods, it is present in mammals including humans.


Related Chemicals:
The fluorinated version of malonic acide is difluoromalonic acid.
Methanedicarboxylic Acid (Malonic Acid) is diprotic; that is, it can donate two protons per molecule.
Malonate or propanedioate compounds include salts and esters of malonic acid, such as:
• Diethyl malonate
• Dimethyl malonate
• Disodium malonate
• Malonyl-CoA


USES OF MALONIC ACID:
This dicarboxylic acid finds application across various industries, including automobiles, food, fragrance, and pharmaceuticals.
The important uses of malonic acid are as follows:
Methanedicarboxylic Acid (Malonic Acid) is used as a precursor in polyester and other polymers.


Methanedicarboxylic Acid (Malonic Acid) is used as a flavoring agent in the fragrance industry.
Methanedicarboxylic Acid (Malonic Acid) is suitable for controlling acidity.
Methanedicarboxylic Acid (Malonic Acid) finds usage in pharmaceutical products.


Methanedicarboxylic Acid (Malonic Acid) is used in the manufacture of biodegradable containers.
Methanedicarboxylic Acid (Malonic Acid) is also a component of surgical adhesives.
Methanedicarboxylic Acid (Malonic Acid) serves as a cross-linking agent between cornstarch and potato starch to enhance its properties.


Methanedicarboxylic Acid (Malonic Acid) is used in the production of vitamins– B1, B6, B2, and amino acids.
Methanedicarboxylic Acid (Malonic Acid) can also be used as a component in alkyd resins.
This substance is widely used in several coating applications to protect objects against UV light damage, oxidation, and corrosion.


A common application of Methanedicarboxylic Acid (Malonic Acid) is as a crosslinker for low-temperature powder coatings.
These are valuable for heat-sensitive substrates.
It is on the US Department of Energy’s list of top chemicals for biomass production.

In food and drug applications, it acts as a natural preservative additive for foods.
Its therapeutic uses include the prevention of resorption of bone tissue in broiler chicks by adding malonic acid to feed.






Methanedicarboxylic Acid (Malonic Acid) and its esters are mainly used in pharmaceutical intermediates, spices, adhesives, resin additives, electroplating polishing agents, thermal welding flux additives, and other aspects.


Methanedicarboxylic Acid (Malonic Acid) is used as a complexing agent and also in the preparation of barbiturate salts.
Methanedicarboxylic Acid (Malonic Acid) is an intermediate of the fungicide rice blast and the plant growth regulator indole ester.
Methanedicarboxylic Acid (Malonic Acid) is used in the pharmaceutical industry to produce Ruminal, Barbital, Vitamin B1, Vitamin B2, Vitamin B6, Phenylbutazone, Amino Acids, etc


As a surface treatment agent for aluminum, malonic acid only generates water and carbon dioxide during thermal decomposition, so there is no pollution problem.
In this regard, compared with acid type treatment agents such as formic acid used in the past, it has great advantages.


Methanedicarboxylic Acid (Malonic Acid) d is utilized as a precursor for the conversion of 1,3-propanediol, a widely used chemical in polyesters and polymers.
Methanedicarboxylic Acid (Malonic Acid) is used to make cinnamic acid, which is a chemical that is utilised to make the anti-inflammatory cin metacin. Malonates are used to make B1 and B6, barbiturates, and a variety of other useful chemicals.
It's utilized as a buffering agent in cosmetics and as a flavoring ingredient in food items.
Methanedicarboxylic Acid (Malonic Acid) is a component of alkyd resins, which are used to protect surfaces against UV radiation, oxidation, and corrosion.


Methanedicarboxylic Acid (Malonic Acid) is used as an intermediate in the manufacture of barbiturates and other pharmaceuticals.
Methanedicarboxylic Acid (Malonic Acid) is a component used as a stabilizer in many high-end cosmetic and pharmaceutical products.

Methanedicarboxylic Acid (Malonic Acid) is also used as building block in chemical synthesis, specifically to introduce the molecular group -CH2-COOH.
Methanedicarboxylic Acid (Malonic Acid) is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation.

Methanedicarboxylic Acid (Malonic Acid) is acts as a building block in organic synthesis.
Methanedicarboxylic Acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which is used in coating applications, thereby protecting against UV light, corrosion and oxidation.
Methanedicarboxylic Acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.
Methanedicarboxylic Acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.



CHEMICAL AND PHYSICAL PROPERTIES OF METHANEDICARBOXYLIC ACID (MALONIC ACID):
Chemical formula, C3H4O4
Molar mass, 104.061 g•mol−1
Density, 1.619 g/cm3
Melting point, 135 to 137 °C (275 to 279 °F; 408 to 410 K) (decomposes)
Boiling point, decomposes
Solubility in water, 763 g/L
Acidity (pKa), pKa1 = 2.83
pKa2 = 5.69[2]
Magnetic susceptibility (χ), -46.3•10−6 cm3/mol
Molecular Weight
104.06 g/mol
XLogP3
-0.8
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
2
Exact Mass
104.01095860 g/mol
Monoisotopic Mass
104.01095860 g/mol
Topological Polar Surface Area
74.6Ų
Heavy Atom Count
7
Computed by PubChem
Formal Charge
0
Complexity
83.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Solubility: Dissolves in alcohol, pyridine, and ether.
Molecular Wt/ Molar Mass: 104.06 g/mol
Density: 1.619 g/cm³
Boiling Point: Decomposes
Melting Point: 135 to 137°C
Nature: Acidic
Color: White
Stability: Usually stable under recommended conditions
Molar heat of combustion: 864 kJ/mol
The heat of vaporization: 92 kJ/mol
CAS, 141-82-2
Molecular Formula, C3H4O4
Molecular weight, 104.06
EINECS:, 205-503-0
Purity, ≥99%
Appearance, White crystal powder
Melting point , 132-135 °C (dec.) (lit.)
Boiling point , 140ºC(decomposition)
Density , 1.619 g/cm3 at 25 °C
Refractive index , 1.478
Flash Point, 157°C
Storage condition, Sealed in dry,Room Temperature
Solubility , 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
Pka, 2.83(at 25ºC)
Stability, Stable. Incompatible with oxidizing agents, reducing agents, bases.
HS Code, 29171910
PH, 3.17(1 mM solution);2.5(10 mM solution);
1.94(100 mM solution)
MDL, MFCD00002707
Water Solubility, 1400 g/L (20 ºC)
Vapor Presure, 0-0.2Pa at 25ºC
Physical and Chemical Properties, Character: white crystal.soluble in water, soluble in ethanol and ether, pyridine.

Methanedicarboxylic Acid (Malonic Acid) does not have a chiral center.
So, Methanedicarboxylic Acid (Malonic Acid) doesn’t exhibit optical isomerism.
Methanedicarboxylic Acid (Malonic Acid) is a hygroscopic solid that sublimes in a vacuum.



CHEMICAL PROPERTIES OF MALONIC ACID:
The chemical properties of malonic acid are as follows:

On Heating:
When Methanedicarboxylic Acid (Malonic Acid) is heated, it gives acetic acid and carbon dioxide.

Reaction with Phosphorus Pentoxide:
On heating a dry mixture of malonic acid and phosphorus pentoxide, carbon suboxide is prepared.

Decomposition:
Methanedicarboxylic Acid (Malonic Acid) has hazardous decomposition products under fire conditions, including carbon oxides.
Also, when heated, Methanedicarboxylic Acid (Malonic Acid) decomposes and emits acrid smoke in addition to irritating fumes.

Organic Reactions:
Methanedicarboxylic Acid (Malonic Acid) reactions are usually similar to a typical carboxylic acid.
It forms amide, anhydrides, esters, and chloride derivatives on reacting with specific reactants.

Malonic anhydride serves as an intermediate in the formation of amide derivatives.
Malonyl chloride is widely used for obtaining diamides or diesters.

Some of the popular organic reactions involving malonic acid are as follows:
It condenses with urea to give barbituric acid.
Malonic acid also condenses with acetone to produce Meldrum’s acid.
This acid is a versatile intermediate and helps in further transformations.

Malonate’s coenzyme A derivative— malonyl-CoA, acts as an important precursor in fatty acid biosynthesis.
It is formed from acetyl CoA when it is acted upon by acetyl-CoA carboxylase.
The malonate gets transferred to an acyl carrier protein for its addition to the fatty acid chain.

Briggs–Rauscher Reaction:
A popular name reaction has malonic acid as its key component. It is an example of an oscillating chemical reaction.

Knoevenagel Condensation:
The reaction is a modification of the aldol condensation reaction (the reaction between benzaldehyde and acetophenone).
It involves the interaction of malonic acid or its diesters with the carbonyl group of a ketone or an aldehyde.
This process is followed by a dehydration reaction.




QUESTIONS AND ANSWERS ABOUT METHANEDICARBOXYLIC ACID (MALONIC ACID):
1. Is malonic acid strong?
Malonic acid is a dicarboxylic acid.
Its pKa1 is 2.83 and pKa2 is 5.69.
The higher the pKa value, the weaker the acid.
Therefore, Methanedicarboxylic Acid (Malonic Acid) is a medium-strong acid.


2. What is the source of malonic acid?
Methanedicarboxylic Acid (Malonic Acid) occurs naturally in some vegetables and fruits.
Beetroot has high concentrations of the calcium salt of malonic acid.
Methanedicarboxylic Acid (Malonic Acid) also occurs in scarlet beans and corn.

3. What is malonic acid soluble in?
Methanedicarboxylic Acid (Malonic Acid) is soluble in water.
In an aqueous solution, this polar molecule forms an H+ ion.
Methanedicarboxylic Acid (Malonic Acid) also dissolves in methyl alcohol, pyridine and ether but is insoluble in hexane.



SAFETY INFORMATION ABOUT METHANEDICARBOXYLIC ACID (MALONIC ACID):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






SYNONYMS OF METHANEDICARBOXYLIC ACID (MALONIC ACID):

dithallium malonate
malonate
malonic acid
malonic acid, 1,3-(14)C2-labeled
malonic acid, 2-(14)C-labeled
malonic acid, diammonium salt
malonic acid, dipotassium salt
malonic acid, disodium salt
malonic acid, disodium salt, 1-(14)C-labeled
malonic acid, dithallium salt
malonic acid, monocalcium salt
malonic acid, monosodium salt
malonic acid, potassium salt
malonic acid, sodium salt
monosodium malonate
propanedioate
thallium malonate
thallous malonate
malonic acid
propanedioic acid
141-82-2
Dicarboxymethane
Carboxyacetic acid
Methanedicarboxylic acid
malonate
Kyselina malonova
USAF EK-695
1,3-Propanedioic acid
Dicarboxylate
Malonicacid
Dicarboxylic acid
Kyselina malonova [Czech]
NSC 8124
UNII-9KX7ZMG0MK
9KX7ZMG0MK
AI3-15375
H2malo
EINECS 205-503-0
MFCD00002707
BRN 1751370
Methanedicarbonic acid
CHEBI:30794
Thallium malonate
HOOC-CH2-COOH
NSC-8124
Propane-1,3-dioic acid
alpha,omega-Dicarboxylic acid
DTXSID7021659
HSDB 8437
NSC8124
4-02-00-01874 (Beilstein Handbook Reference)
1,3-Propanoic acid
PROPANEDIOLIC ACID
METAHNEDICARBOXYLIC ACID
C3H4O4
2fah
Malonic acid, 99%
Malonic acid (8CI)
1o4m
MLI
Malonate dicarboxylic acid
Malonic acid, 99.5%
Propanedioic acid (9CI)
SCHEMBL336
WLN: QV1VQ
MALONIC ACID [MI]
CH2(COOH)2
CHEMBL7942
MALONIC ACID [INCI]
DTXCID401659
SCHEMBL1471092
BDBM14673
Propanedioic acid dithallium salt
Malonic acid, analytical standard
AMY11201
BCP05571
STR00614
Tox21_200534
AC8295
LMFA01170041
s3029
STL194278
Malonic acid, ReagentPlus(R), 99%
AKOS000119034
CS-W019962
DB02175
PROPANEDIOIC ACID MALONIC ACID
NCGC00248681-01
NCGC00258088-01
BP-11453
CAS-141-82-2
SY001875
Malonic acid, SAJ first grade, >=99.0%
FT-0628127
FT-0628128
FT-0690260
FT-0693474
M0028
EN300-18457
Malonic acid, Vetec(TM) reagent grade, 98%
C00383
C02028
C04025
Q421972
J-521669
Z57965450
F1908-0177
Malonic acid, certified reference material, TraceCERT(R)
592A9849-68C3-4635-AA3D-CBC44965EA3A
Malonic acid, sublimed grade, >=99.95% trace metals basis
DICARBOXYLIC ACID C3; PROPANEDIOLIC ACID; METHANEDICARBOXYLIC ACID
InChI=1/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7
Malonic acid, anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), 99%
LML

METHANESULFONIC ACID (MSA)
DESCRIPTION:
Methanesulfonic acid (MSA) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH2SO3H and structure H3C−S(=O)2−OH.
Methanesulfonic acid (MSA) is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).
Salts and esters of methanesulfonic acid are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).



CAS Number, 75-75-2
EC Number, 200-898-6
Linear Formula: CH3SO3H
Molecular Weight: 96.11


Methanesulfonic acid (MSA), the simplest alkanesulfonic acid, is a hygroscopic colorless liquid or white solid, depending on whether the ambient temperature is greater or less than 20 ºC.
Methanesulfonic acid (MSA) is very soluble in water and oxygenated solvents, but sparingly soluble in most hydrocarbons.
In aqueous solution, it is a strong acid (completely ionized).


MSA’s acidity and solubility properties make it industrially valuable as a catalyst in organic reactions, particularly polymerization.
In many applications, its advantage over concentrated sulfuric acid is that it has similar acid strength but is not an oxidant.

The first report of MSA synthesis was in a 1950 patent awarded to John C. Snyder and Aristid V. Grosse of Houdry Process Corp. (subsequently acquired by Air Products).
They heated methane and sulfur trioxide to 200–325 ºC under pressure in the presence of a mercury catalyst.
BASF currently produces the acid via a two-step process in which methanol and elemental sulfur react to give dimethyl disulfide, which is then oxidized to the final product.




Methanesulfonic acid (MSA) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities.
Methanesulfonic acid (MSA) undergoes biodegradation by forming CO2 and sulphate.

Methanesulfonic acid (MSA) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methanesulfonic acid (MSA) solution has been considered a model electrolyte for electrochemical processes.



Methanesulfonic acid (MSA) is hygroscopic in its concentrated form.
Methanesulfonic acid can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).


Methanesulfonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methanesulfonic acid (MSA) has a role as an Escherichia coli metabolite.
Methanesulfonic acid (MSA) is an alkanesulfonic acid and a one-carbon compound.
Methanesulfonic acid (MSA) is a conjugate acid of a methanesulfonate.



HISTORY AND MANUFACTURING OF METHANESULFONIC ACID (MSA):
The first commercial production of MSA, developed in the 1940s by Standard Oil of Indiana (USA), was based on oxidation of methylsulfide by O2 from air.
Although inexpensive, this process suffered from a poor product quality and explosion hazards.

In 1967, the Pennwalt Corporation (USA) developed a different process for methylsulfide (as an water-based emulsion) oxidation using chlorine, followed by extraction-purification.
In 2022 this chlorine-oxidation process was used only by Arkema (France) for making high-purity MSA.
This process is not popular on a large scale, because it co-produces large quantities of hydrochloric acid.


Between years 1970 and 2000 MSA was used only on a relatively small-scale in niche markets (for example, in the microelectronic and electroplating industries since the 1980s), which was mainly due to its rather high price and limited availability.
However, this situation changed around 2003, when BASF launched commercial production of MSA in Ludwigshafen based on a modified version of the aforementioned air oxidation process, using dimethyldisulfide instead of methylsulfide.
The former is produced in one step from methanol from syngas, hydrogen and sulfur.


An even better (lower-cost and environmentally friendlier) process of making methanesulfonic acid was developed in 2016 by Grillo-Werke AG (Germany).
Methanesulfonic acid (MSA) is based on a direct reaction between methane and oleum at around 50 °C and 100 bar in the presence of a potassium persulfate initiator.
This technology was acquired and commercialized by BASF in 2019.


APPLICATIONS OF METHANESULFONIC ACID (MSA):
Since ca. 2000 methanesulfonic acid has become a popular replacement for other acids in numerous industrial and laboratory applications, because;
Methanesulfonic acid (MSA) is a strong acid,
Methanesulfonic acid (MSA) has a low vapor pressure (see boiling points in the "Properties" inset)
Methanesulfonic acid (MSA) is not an oxidant or explosive, like nitric, sulfuric or perchloric acids.


Methanesulfonic acid (MSA) is a liquid at room temperature
Methanesulfonic acid (MSA) is soluble in many organic solvents
Methanesulfonic acid (MSA) forms water-soluble salts with all inorganic cations and with most organic cations,

Methanesulfonic acid (MSA) does not form complexes with metal ions in water, its anion, mesylate, is non-toxic and suitable for pharmaceutical preparations.
The closely related p-toluenesulfonic acid (PTSA) is solid.
Methanesulfonic acid can be used in the generation of borane (BH3) by reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMSO, the complex of BH3 and the solvent is formed.


Electroplating:
Solutions of methanesulfonic acid are used for the electroplating of tin and tin-lead solders.
Methanesulfonic acid (MSA) is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.
Methanesulfonic acid is also a primary ingredient in rust and scale removers.
Methanesulfonic acid (MSA) is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.


Methanesulfonic acid may be used:

As a catalyst to produce linear alkylbenzenes by the addition reaction between long-chain olefins and benzene.
To prepare polyaniline (PANI)/graphene composites with enhanced thermal and electrical properties.
As a catalyst for the transformation of glucose/xylose mixtures to levulinic acid and furfural.


Industrial Cleaning (Equipment & Hard Surface Cleaning):
Methane sulfonic acid (MSA) is widely employed in industrial cleaning applications due to its effective and versatile properties.
Methane sulfonic acid (MSA) acts as a strong acid cleaner, capable of removing various types of contaminants and residues from surfaces and equipment, maintaining the formed salts in solution throughout the cleaning process thanks to their high solubility.
MSA's reactivity and properties make it suitable, efficient, and more sustainable agent for removing mineral deposits, rust, scale, and organic substances.


Oilfield (Well stimulation):
Methane sulfonic acid (MSA) is utilized in the oilfield industry for acidizing treatments, enhancing production by dissolving mineral deposits and improving reservoir permeability.
Methane sulfonic acid (MSA) acts as a catalyst, aiding in the breakdown of complex hydrocarbons and increasing oil recovery efficiency.
Methane sulfonic acid (MSA) offers benefits of reduced corrosion and biodegradability, minimizing equipment corrosion and extending lifespan on one side and reducing maintenance costs on the other.
Additionally, MSA's biodegradable properties contribute to environmentally friendly oilfield practices.


Chemical Industry (Esterification):
Methane sulfonic acid (MSA) is a vital catalyst in the chemical industry, particularly for esterification processes.
Its strong acidic properties enable efficient and selective ester formation from carboxylic acids and alcohols.
MSA's versatility and compatibility with different substrates make Methane sulfonic acid (MSA) an essential component in the synthesis of pharmaceuticals, fragrances, flavors, and specialty chemicals.

Higher selectivity is obtained with Methane sulfonic acid (MSA) than with other strong acids such as nitric or sulfuric acids thanks to its non-oxidizing property, preventing by product formation and product coloration.


Biodiesel (Esterification Catalyst):
Its application in biodiesel value chain involves key stages from esterification catalyst to lower free fatty acid content before transesterification to neutralization to improve quality of glycerol and ester.
MSA-LC in biodiesell production offers dual benefits of reducing corrosion and utilizing cost-effective feedstocks.
As a catalyst, MSA-LC minimizes stainless steel equipment corrosion while enabling efficient conversion processes.

Methane sulfonic acid (MSA) also allows for the use of cheaper feedstocks like agricultural residues, used cooking oil, wastes cooking oils, enhancing the economic viability of biodiesel production.
Methane sulfonic acid (MSA) plays a vital role in making biofuels more sustainable and economically feasible.


Pharmaceuticals (API synthesis, drug formulation, etc.):
Methane sulfonic acid (MSA) plays a significant role in various pharmaceutical applications, ranging from active pharmaceutical ingredient (API) synthesis to drug formulation.
As a catalyst, Methane sulfonic acid (MSA) facilitates key reactions in API synthesis, such as esterification, acylation, and sulfonation.
Its effectiveness in promoting these reactions allows for the efficient production of pharmaceutical intermediates and final APIs.

Methane sulfonic acid (MSA) is also utilized in drug formulation processes, where it aids in solubilizing and stabilizing active compounds.
Its compatibility with a wide range of solvents and its mild nature contribute to the development of safe and effective pharmaceutical formulations.








BENEFITS OF METHANE SULFONIC ACID (MSA):

Methane sulfonic acid (MSA) is a versatile and valuable chemical compound that offers a range of benefits across various industries.
Its unique properties make it a preferred choice for numerous applications.


Strong Acidic Properties:
Methane sulfonic acid (MSA) exhibits high acidity, allowing it to efficiently catalyze chemical reactions.
Its potent acidic properties make it a valuable catalyst in numerous industrial processes, promoting faster and more selective reactions.

Non-Volatile and Non-Oxidizing:
Unlike volatile acids, Methane sulfonic acid (MSA) is non-volatile, ensuring safer handling and reduced risks of harmful vapors.
Additionally, its non-oxidizing nature minimizes the risk of corrosion or degradation of materials, making it compatible with a wide range of substances.


Versatile Solvent:
Methane sulfonic acid (MSA) possesses excellent solvency power, making it an effective solvent for both polar and non-polar compounds. It can dissolve various organic and inorganic substances, facilitating processes such as extraction, purification, and synthesis in industries such as pharmaceuticals, electroplating, and organic chemistry.

Stability and Long Shelf Life:
Methane sulfonic acid is known for its exceptional stability.
Methane sulfonic acid (MSA) can be stored for extended periods without significant decomposition or loss of potency.
This stability ensures a longer shelf life compared to many other corrosive acids, allowing for better inventory management and reduced wastage.

Environmentally Friendly: In terms of environmental impact, MSA stands out positively.
Methane sulfonic acid (MSA) is biodegradable, meaning it can be broken down by natural processes over time.

Methane sulfonic acid (MSA) provides environmental advantages through easy recyclability and the generation of "green" effluent.
Its recyclable nature allows for efficient reuse and waste reduction.
Furthermore, Methane sulfonic acid (MSA) is considered as a "green" effluent as it produces environmentally friendly effluent, minimizing harm to ecosystems


ADVANTAGES OF METHANESULFONIC ACID (MSA):

Methane sulfonic acid (MSA) has Strong, odor-free organic acid
Methane sulfonic acid (MSA) is Non-oxidizing
Methane sulfonic acid (MSA) is Virtually free of metal ions and sulfate


Our unique manufacturing process makes the product free of chlorine and colorless.
Methane sulfonic acid (MSA) is Easy to handle in liquid form
Strong acid prevents the formation of oxidation products.

Reactions at higher temperatures possible
The excellent solubility of Methane sulfonic acid (MSA) in water enables easy phase separations.
Methane sulfonic acid (MSA) Decomposes to form sulfate, carbon dioxide, water and biomass



SAFETY INFORMATION ABOUT METHANESULFONIC ACID (MSA):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product










CHEMICAL AND PHYSICAL PROPERTIES OF METHANESULFONIC ACID (MSA):
Chemical formula, CH4O3S
Molar mass, 96.10 g•mol−1
Appearance, Clear, colourless liquid
Density, 1.48 g/cm3
Melting point, 17 to 19 °C (63 to 66 °F; 290 to 292 K)
Boiling point, 167 °C (333 °F; 440 K) at 10 mmHg, 122 °C/1 mmHg
Solubility in water, miscible
Solubility, Miscible with methanol, diethyl ether.
Immiscible with hexane
log P, −2.424
Acidity (pKa), −1.9
vapor density
3.3 (vs air)
Quality Level
200
vapor pressure
1 mmHg ( 20 °C)
Assay
≥99.0%
form
liquid
refractive index
n20/D 1.429 (lit.)
bp
167 °C/10 mmHg (lit.)
mp
17-19 °C (lit.)
solubility
water: soluble 1,000 g/L at 20 °C
density
1.481 g/mL at 25 °C (lit.)
Molecular Weight
96.11 g/mol
XLogP3-AA
-0.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
0
Exact Mass
95.98811516 g/mol
Monoisotopic Mass
95.98811516 g/mol
Topological Polar Surface Area
62.8Ų
Heavy Atom Count
5
Formal Charge
0
Complexity
92.6
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
CAS number, 75-75-2
EC index number, 607-145-00-4
EC number, 200-898-6
Hill Formula, CH₄O₃S
Chemical formula, CH₃SO₃H
Molar Mass, 96.11 g/mol
HS Code, 2904 10 00
Boiling point, 167 °C (13 hPa)
Density, 1.4812 g/cm3 (18 °C)
Flash point, 189 °C
Melting Point, 20 °C
pH value, Vapor pressure, 0.112 hPa (80 °C)
Solubility, 1000 g/l
Appearance of substance (visual), colourless to brownish
Assay (acidimetric), ≥ 99.0 %
Density (d 20 °C/ 4 °C), 1.478 - 1.48





SYNONYMS OF METHANESULFONIC ACID (MSA):
barium methanesulfonate
BMS-480188
methanesulfonate
methanesulfonic acid
methanesulfonic acid, ammonia salt
methanesulfonic acid, chromium (2+) salt
methanesulfonic acid, chromium (3+) salt
methanesulfonic acid, cobalt (2+) salt
methanesulfonic acid, copper (2+) salt
methanesulfonic acid, iron (2+) salt
methanesulfonic acid, iron (3+)salt
methanesulfonic acid, nickel (2+) salt
methanesulfonic acid, potassium salt
methanesulfonic acid, silver (1+) salt
methanesulfonic acid, sodium salt
methylsulfonate
potassium mesylate
potassium methanesulfonate
METHANESULFONIC ACID
75-75-2
Methylsulfonic acid
Methanesulphonic acid
Mesylic acid
Methanesulfonicacid
Sulfomethane
Kyselina methansulfonova
Methansulfonsaeure
NSC 3718
CCRIS 2783
HSDB 5004
EINECS 200-898-6
METHANE SULFONIC ACID
BRN 1446024
DTXSID4026422
MSA
UNII-12EH9M7279
CHEBI:27376
AI3-28532
NSC-3718
CH3SO3H
MFCD00007518
12EH9M7279
DTXCID806422
NSC3718
EC 200-898-6
4-04-00-00010 (Beilstein Handbook Reference)
J1.465F
ammoniummethanesulfonate
METHANESULFONIC ACID (II)
METHANESULFONIC ACID [II]
Kyselina methansulfonova [Czech]
CH4O3S
metanesulfonic acid
methansulfonic acid
MsOH
methansulphonic acid
methylsulphonic acid
03S
methyl sulfonic acid
methyl-sulfonic acid
methane-sulfonic acid
MeSO3H
methane sulphonic acid
methanesulphonic-acid-
LACTIC ACID(DL)
CH3SO2OH
H3CSO3H
WLN: WSQ1
Methanesulfonic acid solution
Methanesulfonic acid, 99.5%
Methanesulfonic acid, anhydrous
CHEMBL3039600
DL-MALICACIDMONOSODIUMSALT
Methanesulfonic Acid (CH3SO3H)
METHANESULFONIC ACID [MI]
Methanesulfonic acid, HPLC grade
Methanesulfonic acid, >=99.0%
METHANESULFONIC ACID [HSDB]
Tox21_201073
AKOS009146947
AT25153
CAS-75-75-2
NCGC00248914-01
NCGC00258626-01
BP-12823
FT-0628287
M0093
M2059
EN300-29198
Methanesulfonic acid, >=99.0%, ReagentPlus(R)
Methanesulfonic acid, for HPLC, >=99.5% (T)
A934985
Q414168
J-521696
Methanesulfonic acid, Vetec(TM) reagent grade, 98%
F1908-0093
Z281776238
InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4


Methanesulfonic Acid
MSA, Sulphomethane; Acide methanesulfonique; Acide methanesulfonique, Kyselina methansulfonova; Methylsulphonic acid; ácido metanosulfónico; Methansulfonsäure CAS NO:75-75-2
Methanesulfonyl Chloride
Chloro Methyl Sulfone; Mesyl Chloride; Methanesulfonic acid chloride; Methylsulfonyl chloride; cas no: 124-63-0
METHANESULPHONIC ACID (MSA)
Methanesulphonic Acid (MSA) is an organosulfuric and colorless liquid
Methanesulphonic Acid (MSA)'s molecular formula is CH3SO3H and structure is H3C−S(=O)2−OH.
Methanesulphonic Acid (MSA) is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).


CAS NUMBER: 75-75-2

EC NUMBER: 200-898-6

MOLECULAR FORMULA: CH4O3S

MOLECULAR WEIGHT: 96.11 g/mol

IUPAC NAME: methanesulfonic acid



Salts and esters of Methanesulphonic Acid (MSA) are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).
Methanesulphonic Acid (MSA) is hygroscopic in its concentrated form.

Methanesulphonic Acid (MSA) can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4)
Methanesulphonic Acid (MSA) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.

Methanesulphonic Acid (MSA) has a role as an Escherichia coli metabolite.
Methanesulphonic Acid (MSA) is an alkanesulfonic acid and a one-carbon compound.
Methanesulphonic Acid (MSA) is a conjugate acid of a methanesulfonate.


APPLICATIONS:
Methanesulphonic Acid (MSA) has become a popular replacement for other acids in numerous industrial and laboratory applications
Methanesulphonic Acid (MSA) can be used in the generation of borane (BH3) by reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMSO, the complex of BH3 and the solvent is formed.

*Methanesulphonic Acid (MSA) is a strong acid
*Methanesulphonic Acid (MSA) has a low vapor pressure

*Methanesulphonic Acid (MSA) is not an oxidant or explosive, like nitric, sulfuric or perchloric acids.
*Methanesulphonic Acid (MSA) is a liquid at room temperature,

*Methanesulphonic Acid (MSA) is soluble in many organic solvents,
*Methanesulphonic Acid (MSA) forms water-soluble salts with all inorganic cations and with most organic cations,

*Methanesulphonic Acid (MSA) does not form complexes with metal ions in water
*Methanesulphonic Acid (MSA)'s anion and mesylate are non-toxic
*Methanesulphonic Acid (MSA) is suitable for pharmaceutical preparations.

Electroplating
Solutions of Methanesulphonic Acid (MSA) are used for the electroplating of tin and tin-lead solders.
Methanesulphonic Acid (MSA) is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.

Methanesulphonic Acid (MSA) is also a primary ingredient in rust and scale removers.
Methanesulphonic Acid (MSA) is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.

Methanesulphonic Acid (MSA) is the simplest alkanesulfonic acid
Methanesulphonic Acid (MSA) is a hygroscopic colorless liquid or white solid, depending on whether the ambient temperature is greater or less than 20 ºC.

Methanesulphonic Acid (MSA) is very soluble in water and oxygenated solvents, but sparingly soluble in most hydrocarbons.
In aqueous solution, Methanesulphonic Acid (MSA) is a strong acid

Methanesulphonic Acid (MSA)'s acidity and solubility properties make it industrially valuable as a catalyst in organic reactions, particularly polymerization.
Methanesulphonic Acid (MSA) is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis

Methanesulphonic Acid (MSA) is a biodegradable
Methanesulphonic Acid (MSA) is strong acid used in many industrial applications.

Methanesulphonic Acid (MSA) is used in the food industry, agrochemicals, oil and gas, and paint, coatings and adhesives.
Methanesulphonic Acid (MSA)'s common applications include catalysis, plating processes, and rust and scale removal.

Methanesulphonic Acid (MSA) is compatible with biocides.
Methanesulphonic Acid (MSA) is not compatible with water-reactive materials, strong bases, strong reducing agents, amines, hydrogen fluoride, and ethyl vinyl ether.

Methanesulphonic Acid (MSA) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methanesulphonic Acid (MSA) has a role as an Escherichia coli metabolite.

Methanesulphonic Acid (MSA) is an alkanesulfonic acid and a one-carbon compound.
Methanesulphonic Acid (MSA) is a conjugate acid of a methanesulfonate.

Methanesulphonic Acid (MSA) is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents.
Methanesulphonic Acid (MSA) is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters.

Methanesulphonic Acid (MSA) reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex.
Methanesulphonic Acid (MSA) finds application in batteries, because of its purity and chloride absence.

In pharmaceutical industry, Methanesulphonic Acid (MSA) is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan.
Methanesulphonic Acid (MSA) is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
Methanesulphonic Acid (MSA) is involved in the deprotection of peptides.

Methanesulphonic Acid (MSA) is a strong acid and is an important intermediate in the cycling process of sulfur in the environment.
Methanesulphonic Acid (MSA) is an oxidation product of Dimethyl sulfide, and is also used as a sole source of carbon and energy for some gram-negative methylotropic bacteria.


PHYSICAL PROPERTIES:

-Molecular Weight: 96.11 g/mol

-XLogP3-AA: -0.9

-Exact Mass: 95.98811516 g/mol

-Monoisotopic Mass: 95.98811516 g/mol

-Topological Polar Surface Area: 62.8Ų

-Physical Description: Light yellow liquid

-Color: Light Yellow

-Form: Liquid

-Boiling Point: 167 °C

-Melting Point: 20 °C

-Flash Point: 110 °C

-Solubility: Soluble in water

-Density: 1.4812 g/cu cm

-Vapor Pressure: 0.000428 mmHg

-Autoignition Temperature: > 500 °C

-Surface Tension: 5.0584X10-2 N/m

-Refractive Index: 1.4317


Methanesulphonic Acid (MSA) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methanesulphonic Acid (MSA) in large quantities.

Methanesulphonic Acid (MSA) undergoes biodegradation by forming CO2 and sulphate.
Methanesulphonic Acid (MSA) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.

The aqueous Methanesulphonic Acid (MSA) solution has been considered a model electrolyte for electrochemical processes.
Methanesulphonic Acid (MSA) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.

Methanesulphonic Acid (MSA) has a role as an Escherichia coli metabolite.
Methanesulphonic Acid (MSA) is an alkanesulfonic acid and a one-carbon compound.
Methanesulphonic Acid (MSA) is a conjugate acid of a methanesulfonate.


CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 1

-Hydrogen Bond Acceptor Count: 3

-Rotatable Bond Count: 0

-Heavy Atom Count: 5

-Formal Charge: 0

-Complexity: 92.6

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

-Chemical Classes: Other Classes -> Sulfonic Acids, Alkyl


Methanesulphonic Acid (MSA) is the simplest alkanesulfonic acid
Methanesulphonic Acid (MSA) is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.

Methanesulphonic Acid (MSA)'s melting point is 20 °C
Methanesulphonic Acid (MSA)'s boiling point is 167 °C

Methanesulphonic Acid (MSA)'s relative density is 1.4812
Methanesulphonic Acid (MSA) is soluble in water, alcohol and ether

Methanesulphonic Acid (MSA) insoluble in alkanes, benzene and toluene.
Methanesulphonic Acid (MSA) will not subject to decomposition in boiling water and hot alkaline solution.
Methanesulphonic Acid (MSA) also has strong corrosion effect against the metal iron, copper and lead.

Methanesulphonic Acid (MSA) is a raw material for medicine and pesticide.
Methanesulphonic Acid (MSA) can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.

Methanesulphonic Acid (MSA) can be used as solvent, alkylation, catalyst of esterification and polymerization
Methanesulphonic Acid (MSA) is also used in medicine and electroplating industry.

Methanesulphonic Acid (MSA) can also be applied to oxidation.
Methanesulphonic Acid (MSA) is a colourless or light yellow liquid having a melting point of 20° C

Methanesulphonic Acid (MSA) is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, Methanesulphonic Acid (MSA) is used as a starting material for the preparation of methanesulfonyl chloride.
Methanesulphonic Acid (MSA) is a strong acid acting corroding but not oxidizing.


ADVANTAGES:

*Strong, odor-free organic acid
*Non-oxidizing
*Virtually free of metal ions and sulfate
*Our unique manufacturing process makes the product free of chlorine and colorless.
*Easy to handle in liquid form
*Strong acid prevents the formation of oxidation products.
*Reactions at higher temperatures possible
*The excellent solubility in water enables easy phase separations.
*Decomposes to form sulfate, carbon dioxide, water and biomass

Methanesulphonic Acid (MSA) is a strong acid
Methanesulphonic Acid (MSA) is a liquid at room temperature,

Methanesulphonic Acid (MSA) is soluble in many organic solvents,
Methanesulphonic Acid (MSA) is suitable for pharmaceutical preparations.

Methanesulphonic Acid (MSA) is also a primary ingredient in rust and scale removers.
Methanesulphonic Acid (MSA) is very soluble in water and oxygenated solvents, but sparingly soluble in most hydrocarbons.

Methanesulphonic Acid (MSA) is a biodegradable
Methanesulphonic Acid (MSA) is used in the food industry, agrochemicals, oil and gas, and paint, coatings and adhesives.
Methanesulphonic Acid (MSA) is an alkanesulfonic acid and a one-carbon compound.


SYNONYMS:

METHANESULFONIC ACID
75-75-2
Methylsulfonic acid
Methanesulphonic acid
Methanesulfonicacid
Mesylic acid
Kyselina methansulfonova
Sulfomethane
Methansulfonsaeure
NSC 3718
METHANE SULFONIC ACID
CH3SO3H
MFCD00007518
DTXSID4026422
CHEBI:27376
22515-76-0
MSA
NSC-3718
12EH9M7279
CCRIS 2783
HSDB 5004
EINECS 200-898-6
CH4O3S
BRN 1446024
AI3-28532
UNII-12EH9M7279
metanesulfonic acid
methansulfonic acid
MsOH
methansulphonic acid
methylsulphonic acid
03S
methyl sulfonic acid
methyl-sulfonic acid
methane-sulfonic acid
MeSO3H
methane sulphonic acid
methanesulphonic-acid-
LACTIC ACID(DL)
ammonium methanesulphonate
CH3SO2OH
H3CSO3H
WLN: WSQ1
EC 200-898-6
Methane Sulfonic Acid 99%
Methanesulfonic acid solution
Methanesulfonic acid, 99.5%
Methanesulfonic acid, anhydrous
DTXCID806422
CHEMBL3039600
DL-MALICACIDMONOSODIUMSALT
Methanesulfonic acid, HPLC grade
NSC3718
METHANESULFONIC ACID
Tox21_201073
STL264182
AKOS009146947
AT25153
J1.465F
CAS-75-75-2
NCGC00248914-01
NCGC00258626-01
BP-12823
DB-075013
FT-0628287
M0093
M2059
EN300-29198
Methanesulfonic acid
Mesic acid
methane sulfonic acid
Methanesulfonic acid concentrate
Methanesulphonic acid
Methylsulfonic acid
MFCD00007518
66178-40-3
Kyselina methansulfonova
Kyselina methansulfonova
MES
mesylic acid
Methanesulfonic Acid
Methanesulfonic acid
Methanesulfonic acidmissing
methansulfonic acid
Methansulfonsaeure
methyl sulfonic acid

METHANOIC ACID
METHANOIC ACID = FORMIC ACID = ANT ACID


CAS Number: 64-18-6
EC Number: 200-579-1
E number: E236 (preservatives)
Molecular Formula: CH2O2 or HCOOH


Methanoic acid is the simplest carboxylic acid, and has the chemical formula HCOOH and structure H−C(=O)−O−H.
Methanoic acid is an important intermediate in chemical synthesis and occurs naturally, most notably in some ants.
Esters, salts and the anion derived from Methanoic acid are called formats.
Industrially, Methanoic acid is produced from methanol.


In nature, Methanoic acid is found in most ants and in stingless bees of the genus Oxytrigona.
Wood ants from the genus Formica can spray Methanoic acid on their prey or to defend the nest.
The puss moth caterpillar (Cerura vinula) will spray Methanoic acid as well when threatened by predators.
Methanoic acid is also found in the trichomes of stinging nettle (Urtica dioica).


Apart from that, Methanoic acid is incorporated in many fruits such as pineapple (0.21mg per 100g), apple (2mg per 100g) and kiwi (1mg per 100g), as well as in many vegetables, namely onion (45mg per 100g), eggplant (1.34 mg per 100g) and, in extremely low concentrations, cucumber (0.11mg per 100g).
Methanoic acid is a naturally occurring component of the atmosphere primarily due to forest emissions.


Methanoic acid appears as a colorless liquid with a pungent odor.
Methanoic acid's Flash point is 156 °F.
Methanoic acid's Density is 10.2 lb / gal.
Methanoic acid is the simplest carboxylic acid, containing a single carbon.


Methanoic acid occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent.
Methanoic acid is a conjugate acid of formate.
Methanoic acid is a reagent comprised of the organic chemical it that cleaves proteins into peptides at the C- or N-terminal side of an aspartate residue.


Methanoic acid (HCO2H), also called methanoic acid, the simplest of the carboxylic acids, used in processing textiles and leather.
Methanoic acid was first isolated from certain ants and was named after the Latin formica, meaning “ant.”
Methanoic acid is made by the action of sulfuric acid upon sodium formate, which is produced from carbon monoxide and sodium hydroxide.
Synthesis of Methanoic acid is from carbon monoxide and sodium hydroxide.


Methanoic acid is also prepared in the form of its esters by treatment of carbon monoxide with an alcohol such as methanol (methyl alcohol) in the presence of a catalyst.
Methanoic acid is not a typical carboxylic acid; it is distinguished by its acid strength, its failure to form an anhydride, and its reactivity as a reducing agent—a property due to the ―CHO group, which imparts some of the character of an aldehyde.


The methyl and ethyl esters of Methanoic acid are commercially produced.
Concentrated sulfuric acid dehydrates Methanoic acid to carbon monoxide.
Pure Methanoic acid is a colourless, fuming liquid with a pungent odour.
Methanoic acid freezes at 8.4 °C (47.1 °F) and boils at 100.7 °C (213.3 °F).


Methanoic acid is the simplest carboxylic acid.
s discovery in the distillation products of ants is usually attributed to English scientist John Gray in 1671, although there is evidence that a Samuel Fisher made the discovery the year before.
The name “formic” comes from formica1, the Latin word for ant and the name of the genus to which many ants belong.


Although ants and other insects produce significant amounts of Methanoic acid, the large worldwide production of the chemical (870 kt in 2021) is made industrially.
Most of it is made from carbon monoxide, either by heating it with sodium hydroxide to produce sodium formate, which is then acidified, or via the base-catalyzed reaction of CO and methanol to make methyl formate, which is hydrolyzed to the acid.


Methanoic acid is also a major byproduct of acetic acid manufacture.
Methanoic acid has a wide range of uses: in leather tanning, as a decalcifier and cleaning product, as a chemical reducing agent, as a preservative in animal feeds, and for manufacturing its salts and esters.
Methanoic acid's synthetic method can also be reversed to liberate CO.


Foremost among insect-produced chemicals, Methanoic acid is produced by ants in the subfamily Formicinae (almost 300 species) and some bee species as a venom against predators and as a pheromone to warn fellow insects of danger.
Ants in the Formica genus emit Methanoic acid when they bite or spray, causing skin irritation or worse in humans.
Fire ants (Solenopsis spp.) cause even more damage because their venom contains toxic alkaloids.


Methanoic acid is systematically named as methanoic acid.
The common names for simple carboxylic acids come from the Latin or Greek names of their source.
Methanoic acid, although not widely used as a solvent, is of interest as an example of a protic solvent with high acidity.
Methanoic acid and its salts are corrosive and skin sensitizers.


Methanoic acid, better known as Methanoic acid [64-18-6], HCOOH, M r 46.03, is a colorless, corrosive liquid with a pungent odor.
Methanoic acid is completely miscible with water and many polar solvents but only partially miscible with hydrocarbons.
Methanoic acid derives its name from ants (lat. Formica) from which it was first obtained by dry distillation.
The worldwide production of Methanoic acid was about 621 000 t/a in 2012.


Methanoic acid is produced mainly by hydrolysis of methyl formate.
The other important method is acidolysis of formate salts.
Methanoic acid, mp 8.3°C, bp 100.8°C (at 101.3 kPa), is a colorless, clear, corrosive liquid with a pungent odor.
Methanoic acid is the strongest unsubstituted alkyl carboxylic acid (pK a 3.74).


Methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH.
At ambient temperatures, Methanoic acid has a strong, penetrating odor, like acetic acid.
Methanoic acid is used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.


Methanoic acid (HCOOH) is naturally-occurring, organic, and the simplest carboxylic acid.
Methanoic acid occurs naturally in the venom of some ants and bees.
Formate, the conjugate base of Methanoic acid, also occurs naturally in bodily fluids following methanol poisoning.
Methanoic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions.


Methanoic acid is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Methanoic acid is a colourless caustic liquid with a pungent odour. The melting point of Methanoic acid is 8.6°C, and the boiling point is 100.6°C.


Methanoic acid is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings.
Methanoic acid is the isotope labelled analog of Methanoic acid (F692900).
Methanoic acid is the simplest carboxylic acid, and has the chemical formula HCOOH.
Methanoic acid is an important intermediate in chemical synthesis and occurs naturally, most notably in some ants.


Methanoic acid is commonly used in the Oil & Gas Industry, the leather and textile processing industries and is also added to cleaning products and perfumes as well as an effective preservative and antibacterial agent that prevents reduction of nutritional value.
Methanoic acid is the simplest carboxylic acid and forms a liquid with a pungent smell at room temperature.


Methanoic acid is the simplest and has the lowest mole weight of the carboxylic acids, in which a single hydrogen atom is attached to the carboxyl group (HCOOH).
Methanoic acid (systematically called methanoic acid) is the simplest carboxylic acid.


If a methyl group is attached to the carboxyl group, Methanoic acid is acetic acid.
Methanoic acid occurs naturally in the body of ants and in the stingers of bees.
Functionally, it is not only an acid but also an aldehyde; Methanoic acid reacts with alcohols to form esters as an acid and it is easily oxidized which imparts some of the character of an aldehyde.


Pure Methanoic acid is a colorless, toxic, corrosive and fuming liquid, freezing at 8.4 C and boiling at 100.7 C.
Methanoic acid is soluble in water, ether, and alcohol.
Methanoic acid is prepared commercially from sodium formate with the reaction of condensed sulfuric acid.


The structure of Methanoic acid involves a carbon atom having a single bond with hydrogen, a double bond with oxygen, and another single bond with oxygen which is in turn bonded with a hydrogen atom
Methanoic acid is miscible with water and most polar organic solvents and somewhat soluble in hydrocarbons.
In hydrocarbons and in the vapor phase, Methanoic acid consists of hydrogen-bonded dimers rather than individual molecules.


Due to its hydrogen bonding tendency, gaseous Methanoic acid does not obey the ideal gas law.
Solid Methanoic acid, which can be found in either of the two polymorphs, consists of an effectively endless network of hydrogen-bonded Methanoic acid molecules.
Methanoic acid forms a low boiling azeotrope with water (% 22.4).


Liquid Methanoic acid tends to overcook.
Methanoic acid (formic acid, HCOOH) is Colourless, pungent, liquid carboxylic acid.
Methanoic acid occurs naturally in a variety of sources, such as stinging ants, nettles, pine needles, and sweat.
The simplest of the carboxylic acids, Methanoic acid can be produced by the action of concentrated sulphuric acid on sodium methanoate.


The main use of Methanoic acid is as a preservative and antibacterial in livestock feed.
Methanoic acid stops certain rotting processes and allows the feed to retain its nutritional value for a longer period of time.
Methanoic acid is a colourless, fuming liquid that is miscible with water.


In the vapor phase, Methanoic acid consists of hydrogen bonded dimers (see picture, right) rather than individual molecules.
The structure of Methanoic acid is simple since it is the first carboxylic Acid of the series and it contains a single carbon atom, which gives it the name of methanoic acid.


In the gas phase, significant deviations from the ideal gas law arise as a result of this hydrogen bonding.
In its liquid and solid state, Methanoic acid can be thought of as an effectively infinite network of hydrogen bonded molecules.
Being the first in the carboxylic acid series, Methanoic acid shares most of the same chemical properties, and so it will react with alkalis to form water soluble formate salts.


But Methanoic acid is unique among the carboxylic acids in that it reacts with alkenes to form formate esters.
In the presence of sulfuric and hydrofluoric acids, a variant of the Gatterman-Koch reaction takes place instead, and Methanoic acid adds to the alkene to produce a larger carboxylic acid.
Methanoic acid is a colourless transparent fuming liquid with a strong pungent odor.


Methanoic acid is a strong acid.
Methanoic acid is miscible with water in any ratio and forms an azeotropic mixture above the boiling point of both.
Methanoic acid is miscible with many organic solvents, but insoluble in hydrocarbons.
Methanoic acid reactions with strong oxidants may occur.



USES and APPLICATIONS of METHANOIC ACID:
Methanoic acid is used Adhesives & Sealants, Agricultural Chemicals, Agriculture Intermediates, Animal Nutrition & Feed, Antifreeze & Coolant, Chemical Synthesis, Corrosion Inhibitors, Feed Additives, Flavor & Fragrance, Food & Beverage, Food Additives, Industrial Chemicals, Inks & Digital Inks, Pharmaceutical & Fine Chemicals, Plastic, Resin & Rubber, Textile Auxiliaries, Benzoates, Coatings, Esters, Plasters, Preservatives


Methanoic acid is used as a mixture with citric acid or HCl because alone it is unable to remove iron oxide deposits.
Methanoic acid is used in major industrial chemicals in the group of saturated monocarboxylic acids.
Methanoic acid is used as a reducing agent to reduce sodium and potassium dichromate.


Methanoic acid is used Agriculture & Animal Care, CASE - Coatings, Adhesives, Sealants & Elastomers, Chemical & Materials Manufacturing, Food & Beverage, Personal Care & Pharmaceutical, Surface Treatment - Fluids, Lubricants & Metalworking, Textiles
Methanoic acid is also significantly used in the production of leather, including tanning (23% of the global consumption in 2009), and in dyeing and finishing textiles (9% of the global consumption in 2009) because of its acidic nature.


Methanoic acid is used as a coagulant in the production of rubber and consumed 6% of global production in 2009.
Methanoic acid is also used in place of mineral acids for various cleaning products, such as limescale remover and toilet bowl cleaner. Some formate esters are artificial flavorings and perfumes.
Methanoic acid application has been reported to be an effective treatment for warts.


Methanoic acid and its salts are used primarily in the feed industry, grass silage, leather tanning, and anti-icing.
Other applications of Methanoic acid include textile dyeing and finishing, food additives, natural rubber, drilling fluids, and various chemical processes.
In diluted forms, Methanoic acid and formate esters are used as artificial flavorings and perfume additives.


Methanoic acid is used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
In agriculture, Methanoic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites.
Methanoic acid is useful in leather tanning, textile dyeing and finishing, and in rubber production.


Methanoic acid replaces mineral acids in limescale removers and other cleaning products.
Methanoic acid is commonly used as a preservative and antibacterial agent in livestock feed.
Methanoic acid is used as a potential energy source in the preparation of fuel cells.
Methanoic acid is also used in the chemical synthesis of various anti-inflammatory and anti-microbial agents.


Methanoic acid has many applications as a preservative and antibacterial agent (especially in animal feed) but is also a major component in the textile and leather industry.
Within a laboratory setting, Methanoic acid is often used in reverse-phase HPLC and the synthesis of other chemicals.
Recently, Methanoic acid has been a topic of interest in the renewable energy sector with potential use in the manufacture of fuel cells.


Useful material in the dyeing and tanning industries, but other competing acids have, as a rule, been cheaper and the use of Methanoic acid has therefore been restricted to a few cases for which it has peculiar advantages.
Methanoic acid is used as a chemical intermediate and solvent, and as a disinfectant.


Methanoic acid is also in processing textiles and leathers, electroplating and coagulating latex rubber.
Methanoic acid is used for decalcifier; reducer in dyeing for wool fast colours; dehairing and plumping hides; tanning; electroplating; coagulating rubber latex; silage and grain preservation;aidditive in regenerating old rubber; solvents of perfume; lacquers; alkylating agent for alcohols; carboxylating agent for tertiary compounds.


Methanoic acid is used for decalcifier; reducer in dyeing for wool fast colours; dehairing and plumping hides; tanning; electroplating; coagulating rubber latex; silage and grain preservation;aidditive in regenerating old rubber; solvents of perfume; lacquers; alkylating agent for alcohols; carboxylating agent for tertiary compounds.
Methanoic acid is also used as an intermediate for the production of a wide variety of products in the chemicals and pharmaceutical industries.


Methanoic acid is used to produce insecticides and for dyeing, tanning, and electroplating.
The main use of Methanoic acid is for livestock feed in Europe, as a preservative and antibacterial agent.
Methanoic acid can be sprayed on fresh hay or other silage to stop or delay certain decay processes.
Methanoic acid therefore allows the feed to survive longer, and so Methanoic acid is widely used to preserve winter feed for cattle.


In the poultry industry, Methanoic acid is sometimes added to feed to kill salmonella bacteria.
Some beekeepers also use Methanoic acid as a fumigant to kill a mite which attacks the bees.
Methanoic acid is used in textile dyeing and finishing, leather tanning, nickel plating baths, electroplating, coagulating rubber latex, regenerating old rubber, and dehairing and plumping hides, and in some commercial paint strippers.


Methanoic acid is used to make metal salts, including nickel, cadmium, and potassium formats.
Methanoic acid is used as a solvent for perfumes, and in the manufacturing of lacquers, glass, vinyl resin plasticizers, and formate esters for flavor and fragrance.
Methanoic acid is used in the synthesis of the artificial sweetener, aspartame.


Therefore, Methanoic acid is widely used to protect the winter feed of cattle.
In the poultry industry, Methanoic acid is also added to the feed to kill some bacteria.
Thanks to its acidic structure, Methanoic acid is widely used in leather production and textile dyeing and polishing processes.
Methanoic acid is used as a coagulant in rubber production.


Methanoic acid is used in various cleaning products such as it descaler and toilet bowl cleaner.
Beekeepers use Methanoic acid as a tick killer against tracheal mite (Acarapis woodi) and Varroa destroyer mite and Varroa jacobsoni mite.
Methanoic acid application becomes an effective treatment for warts.
Methanoic acid can be used directly in its fuel cells and indirectly in hydrogen fuel cells.


Methanoic acid can be used as an intermediary to produce isobutanol using microbes from CO2.
Methanoic acid and its aqueous solution can dissolve many metals, metal oxides, hydroxides and salts, and the resulting formate can be dissolved in water, so it can be used as a chemical cleaning agent.


Methanoic acid can be used for cleaning equipment containing stainless steel materials.
Methanoic acid has good volatility and is easily removed after cleaning, so it can be used for cleaning projects sensitive to residues.
In the cleaning concentration, Methanoic acid is non-toxic and harmless to human body, and the corrosion of metal is not as strong as that of inorganic acid, so it is a safe cleaning agent.


-Agriculture:
A major use of Methanoic acid is as a preservative and antibacterial agent in livestock feed.
In Europe, Methanoic acid is applied on silage, including fresh hay, to promote the fermentation of lactic acid and to suppress the formation of butyric acid; it also allows fermentation to occur quickly, and at a lower temperature, reducing the loss of nutritional value.
Methanoic acid arrests certain decay processes and causes the feed to retain its nutritive value longer, and so it is widely used to preserve winter feed for cattle.
In the poultry industry, Methanoic acid is sometimes added to feed to kill E. coli bacteria.
Methanoic acid is used as a preservative for silage and (other) animal feed constituted 30% of the global consumption in 2009.
Beekeepers use Methanoic acid as a miticide against the tracheal mite (Acarapis woodi) and the Varroa destructor mite and Varroa jacobsoni mite.


-Methanoic acid is used in industry:
Manufacturers and researchers in the industrial sector keep coming up with new ideas for using Methanoic acid.
At present, Methanoic acid is used as:
*an intermediate for cleaning, tanning or acidifying preparations,
*a cleaner used to clear different types of industrial installations,
*an additive for greases,
*an ingredient of medicines for rheumatism or vasoconstricting medicines,
*an additive for animal feeds and fungicides,
*an ingredient of cosmetics for body care and regeneration.


-Energy:
Methanoic acid can be used in a fuel cell (it can be used directly in Methanoic acid fuel cells and indirectly in hydrogen fuel cells).
Electrolytic conversion of electrical energy to chemical fuel has been proposed as a large-scale source of formate by various groups.
The formate could be used as feed to modified E. coli bacteria for producing biomass.
Natural microbes do exist that can feed on Methanoic acid or formate.
Methanoic acid has been considered as a means of hydrogen storage.
The co-product of this decomposition, carbon dioxide, can be rehydrogenated back to Methanoic acid in a second step.
Methanoic acid contains 53 g/L hydrogen at room temperature and atmospheric pressure, which is three and a half times as much as compressed hydrogen gas can attain at 350 bar pressure (14.7 g/L).
Pure Methanoic acid is a liquid with a flash point of +69 °C, much higher than that of gasoline (−40 °C) or ethanol (+13 °C).
It is possible to use Methanoic acid as an intermediary to produce isobutanol from CO2 using microbes.


-Soldering:
Methanoic acid has a potential application in soldering.
Due to its capacity to reduce oxide layers, Methanoic acid gas can be blasted at an oxide surface in order to increase solder wettability.


-Chromatography:
Methanoic acid is used as a volatile pH modifier in HPLC and capillary electrophoresis.
Methanoic acid is often used as a component of mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) analysis and separation techniques for the separation of hydrophobic macromolecules, such as peptides, proteins and more complex structures including intact viruses.
Especially when paired with mass spectrometry detection, Methanoic acid offers several advantages over the more traditionally used phosphoric acid.


-In which sectors is Methanoic acid used?
*In farm animal feeds
*In leather and textile production sectors
*In the rubber industry
*In cleaning products
*in the beekeeping industry
*In the fuel industry
*In the production of isobutanol



WHAT IS METHANOIC ACID AND HOW IS METHANOIC ACID PRODUCED?
Methanoic acid (in Latin: Acidum formicum) is also called methanoic acid or hydrogen carboxylic acid.
Together with butyric and acetic acids, Methanoic acid belongs to the group of carboxylic acids, which are the simplest organic chemical compounds formed from hydrocarbons that are known to people.

It is possible to produce Methanoic acid by quite different methods.
First, Methanoic acid can be produced from methyl and formamide.
When methanol and carbon monoxide are combined in the presence of a strong base, the result is methyl formate, according to the chemical equation:
CH3OH + CO → HCO2CH3

In industry, this reaction is carried out in the liquid phase at high pressure.
Typical reaction conditions are 80 °C and 40 atm.
The most commonly used base is sodium methoxide.
Hydrolysis of methyl formate produces Methanoic acid:
HCO2CH3 + H2O → HCOOH + CH3OH
Effective hydrolysis of methyl formate requires a lot of water.

Some routes proceed indirectly, by first treating methyl formate with ammonia to give formamide, which is then hydrolyzed with sulfuric acid:
HCO2CH3 + NH3 → HC(O)NH2 + CH3OH
2 HC(O)NH2 + 2H2O + H2SO4 → 2HCO2H + (NH4)2SO4

A disadvantage of this method is the need to dispose of the ammonium sulfate by-product.
This problem has prompted some manufacturers to develop energy-efficient methods for separating Methanoic acid directly from the excess water used in hydrolysis.

Significant amounts of Methanoic acid are produced as a by-product in the production of other chemicals.
Methanoic acid can also be obtained by aqueous catalytic partial oxidation of wet biomass by the OxFA process.
A Keggin-type polyoxometalate (H5PV2Mo10O40) is used as the homogeneous catalyst to convert sugar, wood, waste paper or cyanobacteria into
Methanoic acid and CO2 as the only by-product. Methanoic acid yields of up to % 53 can be achieved.
In the laboratory, Methanoic acid can be obtained by heating oxalic acid in glycerol and extraction by steam distillation.
Methanoic acid can be obtained by electrochemical reduction of CO.
Because of the high amount of its in ants, Methanoic acid can be produced through biosynthesis.



HOW CAN WE PRODUCED METHANOIC ACID?
The chemical formula of Methanoic acid is HCOOH – it is a derivative of:
*a reaction of carbon monoxide and methanol,
*a reaction of carbon monoxide and sodium hydroxide or:
*a result of the process of oxidation of hydrocarbons.
Methanoic acid is produced from chemical intermediates obtained under laboratory conditions.



WHAT ELSE DISTINGUISHES METHANOIC ACID?
Other characteristic physical properties of methanoic acid include solubility in water, benzene and ethyl alcohol and the corrosive effect.
The attention of manufacturers in multiple industries is particularly drawn to the specific chemical properties of Methanoic acid, such as: the capability to increase the corrosion rate of various materials, electric conduction or fungicidal and bactericidal properties.



PROPERTIES of METHANOIC ACID:
Methanoic acid odor at room temperature, comparable to the related acetic acid.
Methanoic acid is about ten times stronger than acetic acid.
Methanoic acid is miscible with water and most polar organic solvents, and is somewhat soluble in hydrocarbons.
In hydrocarbons and in the vapor phase, Methanoic acid consists of hydrogen-bonded dimers rather than individual molecules.
Owing to its tendency to hydrogen-bond, gaseous Methanoic acid does not obey the ideal gas law.
Solid Methanoic acid, which can exist in either of two polymorphs, consists of an effectively endless network of hydrogen-bonded Methanoic acid molecules.
Methanoic acid forms a high-boiling azeotrope with water (22.4%). Liquid Methanoic acid tends to supercool.



HCOOH CHEMICAL PROPERTIES of METHANOIC ACID:
Methanoic acid reduce mercuric chloride into mercurous chloride forming a white precipitate.
The chemical equation is given below.
HCOOH + 2HgCl2 → Hg2Cl2 + 2HCl + CO2

Methanoic acid reacts with phosphoric pentachloride and forms formyl chloride, phosphoryl chloride and hydrogen chloride.
HCOOH + PCl5 → HCOCl + POCl3 + HCl
Methanoic acid as the name suggests is acidic and is capable of turning blue litmus into red litmus.
Methanoic acid is a Hydrogen bond donor.

Methanoic acid contains carbon and carbon forms of covalent bonds in most cases.
In Methanoic acid as well, carbon forms all covalent bonds. Methanoic acid contains only covalent bonds.
Methanoic acid is capable of reducing mercuric chloride into mercurous chloride which results in a white precipitate.
The equation to the reaction is given below
HCOOH + 2HgCl2 → Hg2Cl2 + 2HCl + CO2

Methanoic acid also reacts with phosphoric pentachloride and results in forming of formyl chloride, phosphoryl chloride, and hydrogen chloride.
Given below is the reaction to the equation.
HCOOH + PCl5 → HCOCl + POCl3 + HCl



PHYSICAL PROPERTIES of METHANOIC ACID:
The IUPAC name of Methanoic acid is Methanoic acid, as we've seen earlier.
Methanoic acid is the first member of the homologous series of carboxylic acids.
So we've now seen the structure and IUPAC name of Methanoic acid.
Methanoic acid in appearance is like a thick transparent liquid and by its looks, it is impossible to identify it.
The melting point of Methanoic acid is not very high.
Methanoic acid melting point is merely 8.4°C.
The boiling point of Methanoic acid is a little over that of water.
The boiling point of Methanoic acid is 100.8°C.
Methanoic acid isn't a very dense liquid and has a low density of 1.22g/cm³.
Since Methanoic acid is the first member of the homologous series, the molecular weight of the acid isn't very high as well.
The molecular weight of Methanoic acid is 46.03 g/mol.
Methanoic acid has a characteristic pungent and irritating odour.
Methanoic acid is soluble and miscible in water.



CHEMICAL REACTIONS of METHANOIC ACID:
Decomposition
Methanoic acid readily decomposes by dehydration in the presence of concentrated sulfuric acid to form carbon monoxide and water:
HCO2H → H2O + CO
Treatment of Methanoic acid with sulfuric acid is a convenient laboratory source of CO.
In the presence of platinum, Methanoic acid decomposes with a release of hydrogen and carbon dioxide.
HCO2H → H2 + CO2
Soluble ruthenium catalysts are also effective.
Carbon monoxide free hydrogen has been generated in a very wide pressure range (1–600 bar).



REACTANT of METHANOIC ACID:
Methanoic acid shares most of the chemical properties of other carboxylic acids.
Because of its high acidity, solutions in alcohols form esters spontaneously.
Methanoic acid shares some of the reducing properties of aldehydes, reducing solutions of metal oxides to their respective metal.
Methanoic acid is a source for a formyl group for example in the formylation of methylaniline to N-methylformanilide in toluene.
In synthetic organic chemistry, Methanoic acid is often used as a source of hydride ion, as in the Eschweiler-



CLARKE REACTION:
The Eschweiler–Clark reaction
Methanoic acid is used as a source of hydrogen in transfer hydrogenation, as in the Leuckart reaction to make amines, and (in aqueous solution or in its azeotrope with triethylamine) for hydrogenation of ketones.



Addition to alkenes
Methanoic acid is unique among the carboxylic acids in its ability to participate in addition reactions with alkenes.
Methanoic acids and alkenes readily react to form formate esters.
In the presence of certain acids, including sulfuric and hydrofluoric acids, however, a variant of the Koch reaction occurs instead, and Methanoic acid adds to the alkene to produce a larger carboxylic acid.



METHANOIC ACID ANHYDRIDE:
An unstable formic anhydride, H(C=O)−O−(C=O)H, can be obtained by dehydration of Methanoic acid with N,N′-dicyclohexylcarbodiimide in ether at low temperature.



PRODUCTION of METHANOIC ACID:
In 2009, the worldwide capacity for producing Methanoic acid was 720 thousand tonnes (1.6 billion pounds) per year, roughly equally divided between Europe (350 thousand tonnes or 770 million pounds, mainly in Germany) and Asia (370 thousand tonnes or 820 million pounds, mainly in China) while production was below 1 thousand tonnes or 2.2 million pounds per year in all other continents.
Methanoic acid is commercially available in solutions of various concentrations between 85 and 99 w/w %.

As of 2009, the largest producers are BASF, Eastman Chemical Company, LC Industrial, and Feicheng Acid Chemicals, with the largest production facilities in Ludwigshafen (200 thousand tonnes or 440 million pounds per year, BASF, Germany), Oulu (105 thousand tonnes or 230 million pounds, Eastman, Finland), Nakhon Pathom (n/a, LC Industrial), and Feicheng (100 thousand tonnes or 220 million pounds, Feicheng, China).
2010 prices ranged from around €650/tonne (equivalent to around $800/tonne) in Western Europe to $1250/tonne in the United States.
Methanoic acid is produced as a by-product in the manufacture of acetic acid.

However, the industrial demand for Methanoic acid is higher than can be made from this route, so dedicated production routes have been developed.
One method combines methanol and carbon monoxide in the presence of a strong base, such as sodium methoxide, to produce methyl formate, according to the chemical equation:
CH3OH + CO HCOOCH3
Hydrolysis of this produces Methanoic acid:
HCOOCH3 + H2O HCOOH + CH3OH

From methyl formate and formamide
When methanol and carbon monoxide are combined in the presence of a strong base, the result is methyl formate, according to the chemical equation:
CH3OH + CO → HCO2CH3
In industry, this reaction is performed in the liquid phase at elevated pressure.
Typical reaction conditions are 80 °C and 40 atm.
The most widely used base is sodium methoxide.

Hydrolysis of the methyl formate produces Methanoic acid:
HCO2CH3 + H2O → HCOOH + CH3OH
Efficient hydrolysis of methyl formate requires a large excess of water.
Some routes proceed indirectly by first treating the methyl formate with ammonia to give formamide, which is then hydrolyzed with sulfuric acid:
HCO2CH3 + NH3 → HC(O)NH2 + CH3OH
2 HC(O)NH2 + 2H2O + H2SO4 → 2HCO2H + (NH4)2SO4

A disadvantage of this approach is the need to dispose of the ammonium sulfate byproduct.
This problem has led some manufacturers to develop energy-efficient methods of separating Methanoic acid from the excess water used in direct hydrolysis.
In one of these processes, used by BASF, the Methanoic acid is removed from the water by liquid-liquid extraction with an organic base.



NICHE AND OBSOLETE CHEMICAL ROUTES:
By-product of acetic acid production
A significant amount of Methanoic acid is produced as a byproduct in the manufacture of other chemicals.
At one time, acetic acid was produced on a large scale by oxidation of alkanes, by a process that cogenerates significant Methanoic acid.
This oxidative route to acetic acid has declined in importance so that the aforementioned dedicated routes to Methanoic acid have become more important.



HYDROGENATION of CARBON DIOXIDE:
The catalytic hydrogenation of CO2 to Methanoic acid has long been studied.
This reaction can be conducted homogeneously.



OXIDATION of BIOMASS:
Methanoic acid can also be obtained by aqueous catalytic partial oxidation of wet biomass by the OxFA process.
A Keggin-type polyoxometalate (H5PV2Mo10O40) is used as the homogeneous catalyst to convert sugars, wood, waste paper, or cyanobacteria to Methanoic acid and CO2 as the sole byproduct.
Yields of up to 53% Methanoic acid can be achieved.



LABORATORY METHODS:
In the laboratory, Methanoic acid can be obtained by heating oxalic acid in glycerol and extraction by steam distillation.
Glycerol acts as a catalyst, as the reaction proceeds through a glyceryl oxalate intermediate.
If the reaction mixture is heated to higher temperatures, allyl alcohol results.
The net reaction is thus:
C2O4H2 → HCO2H + CO2
Another illustrative method involves the reaction between lead formate and hydrogen sulfide, driven by the formation of lead sulfide.
Pb(HCOO)2 + H2S → 2HCOOH + PbS



ELECTROCHEMICAL PRODUCTION:
It has been reported that formate can be formed by the electrochemical reduction of CO2 (in the form of bicarbonate) at a lead cathode at pH 8.6:
HCO−3 + H2O + 2e− → HCO−2 + 2OH−
or
CO2 + H2O + 2e− → HCO−2 + OH−
If the feed is CO2 and oxygen is evolved at the anode, the total reaction is:
CO2 + OH− → HCO−2 + 1/2 O2



METHODS of MANUFACTURING METHANOIC ACID:
By reacting methyl formate with formamide:
Upon the reaction of methanol and carbon monoxide in the presence of a strong base, methyl formate is formed.
The chemical reaction to the above-mentioned method is given below
CH3OH + CO → HCO2CH3

The method is also used in industries, the reaction is performed under special conditions.
Typical conditions for the feasible progress of the reaction are
80 °C temperature
40 atm pressure
liquid phase

The most commonly used base in this process is sodium methoxide.
Hydrolysis of the obtained methyl formate gives our desired compound as the main product.
Along with this we also get certain byproducts.
The reaction of the hydrolysis goes as follows
HCO2CH3 + NH3 → HC(O)NH2 + CH3OH
2 HC(O)NH2 + 2H2O + H2SO4 → 2HCO2H + (NH4)2SO4
However, the above-mentioned procedure has a disadvantage.
We need to dispose of the ammonium sulfate which is a by-product of the reaction.



ARTIFICIAL PHOTOSYNTHESIS:
In August 2020, researchers at Cambridge University announced a stand-alone advanced 'photo sheet' technology that converts sunlight, carbon dioxide and water into oxygen and Methanoic acid with no other inputs.



BIOSYNTHESIS:
Methanoic acid is named after ants which have high concentrations of the compound in their venom.
In ants, Methanoic acid is derived from serine through a 5,10-methyltetrahydrofolate intermediate.
The conjugate base of Methanoic acid, formate, also occurs widely in nature.
An assay for Methanoic acid in body fluids, designed for the determination of formate after methanol poisoning, is based on the reaction of formate with bacterial formate dehydrogenase.



IS METHANOIC ACID A STRONG ACID?
A strong acid is Methanoic acid which dissociates entirely in aqueous solution.
A weak acid is Methanoic acid which dissociates partially in aqueous solution.
Methanoic acid (methanoic acid, HCOOH) is a weak acid, which occurs naturally in the stings of bees and ants.
Methanoic acid was once prepared by the distillation of ants.



IS of METHANOIC ACID HARMFUL TO HUMANS?
Methanoic acid is an unpleasant chemical that is found in certain ant species ‘ sprayed venom and in the secretion produced from some stinging nettles.
Methanoic acid is very effective at low concentrations.
Since it is an antibacterial material, humans use Methanoic acid as a food preservative.



WHAT IS THE SOURCE of METHANOIC ACID:
The simplest carboxylic acid, with one carbon in Methanoic acid.
Methanoic acid exists naturally in various ways like the bee and ant stings venom, and is a valuable organic synthetic reagent.
In livestock feed, Methanoic acid is mainly used as a preservative and antibacterial agent.



WHICH IS MORE ACIDIC METHANOIC ACID OR ACETIC ACID?
Methanoic acid does not have such a contributing group of electrons, so is stronger than acetic acid.
For this reason, Methanoic acid is a stronger acid than acetic acid.
This methyl group is an electron donation group that can destabilize the conjugate base’s negative charge which is why acetic acid is less acidic than Methanoic acid.



HOW DO YOU NEUTRALIZE METHANOIC ACID?
Baking soda (NaHCO3) is also used for the neutralization of acids, including Methanoic acid.
You would want to neutralize it with a thick paste of sodium bicarbonate water (NaHCO3) if you were to spill some Methanoic acid solution on your skin or on the concrete.



PREPARATION METHOD of METHANOIC ACID:
The desulfurized and compressed carbon monoxide is passed into a reactor containing 20% ~ 30% sodium hydroxide solution and reacted at 160~200 ℃ and 1.4 ~ 1.6MPa to form sodium formate, then 76% Methanoic acid-water azeotrope was obtained by treatment with dilute sulfuric acid, which can be further concentrated and refined.



HISTORY of METHANOIC ACID:
Some alchemists and naturalists were aware that ant hills give off an acidic vapour as early as the 15th century.
The first person to describe the isolation of this substance (by the distillation of large numbers of ants) was the English naturalist John Ray, in 1671.
Ants secrete Methanoic acid for attack and defense purposes.

Methanoic acid was first synthesized from hydrocyanic acid by the French chemist Joseph Gay-Lussac.
In 1855, another French chemist, Marcellin Berthelot, developed a synthesis from carbon monoxide similar to the process used today.
Methanoic acid was long considered a chemical compound of only minor interest in the chemical industry.
In the late 1960s, however, significant quantities became available as a byproduct of acetic acid production.
Methanoic acid now finds increasing use as a preservative and antibacterial in livestock feed.

For over 600 years naturalists knew that ant hills gave off an acidic vapor.
In 1671, the English naturalist John Ray describe the isolation of the active ingredient.
To do this he collected and distilled a large numbers of dead ants, and the acid he discovered later became known as Methanoic acid from the Latin word for ant, formica.

Its proper IUPAC name is now methanoic acid.
The first synthesis of Methanoic acid was by the French chemist Joseph Gay-Lussac, who used hydrocyanic acid as a starting material.
In 1855, another French chemist, Marcellin Berthelot, developed a synthesis from carbon monoxide that is similar to the one used today.
Methanoic acid is also present in a natural state in stinging nettles, and is reponsible for the burning feeling on contact with them.

Methanoic acid is also found in the stings and bites of many insects, including bees and ants, which use it as a chemical defence mechanism.
When the ant contracts its poison gland, the Methanoic acid stored in this gland passes in the sting and is propelled out in jets (up to a distance of one metre in some species!) toward the attackers of the ant.
Since Methanoic acid has a pH of ~2-3, the attackers usually flee, or are killed.



ALTERNATIVE PARENTS of METHANOIC ACID:
*Monocarboxylic acids and derivatives
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



PHYSICAL and CHEMICAL PROPERTIES of METHANOIC ACID:
Flash point: 69 °C (156 °F; 342 K)
Autoignition temperature: 601 °C (1,114 °F; 874 K)
Explosive limits: 14–34% 18–57% (90% solution)
Chemical formula: CH2O2
Molar mass: 46.025 g·mol−1
Appearance: Colorless fuming liquid
Odor: Pungent, penetrating
Density: 1.220 g/mL
Melting point: 8.4 °C (47.1 °F; 281.5 K)
Boiling point: 100.8 °C (213.4 °F; 373.9 K)
Solubility in water: Miscible
Solubility: Miscible with ether, acetone, ethyl acetate, glycerol, methanol, ethanol
Partially soluble in benzene, toluene, xylenes

log P: −0.54
Vapor pressure: 35 mmHg (20 °C)
Acidity (pKa): 3.745
Conjugate base: Formate
Magnetic susceptibility (χ): −19.90×10−6 cm3/mol
Refractive index (nD): 1.3714 (20 °C)
Viscosity: 1.57 cP at 268 °C
Structure Molecular shape: Planar
Dipole moment: 1.41 D (gas)
Std molar entropy (S⦵298): 131.8 J/mol K
Std enthalpy of formation (ΔfH⦵298): −425.0 kJ/mol
Std enthalpy of combustion (ΔcH⦵298): −2
Molecular Weight: 46.025

XLogP3-AA: -0.2
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 0
Exact Mass: 46.005479302
Monoisotopic Mass: 46.005479302
Topological Polar Surface Area: 37.3 Ų
Heavy Atom Count: 3
Formal Charge: 0
Complexity: 10.3
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: liquid
Color: colorless
Odor: stinging
Melting point: 8,5 °C
Initial boiling point and boiling range: 100,80 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper explosion limit: 38 %(V)
Lower explosion limit: 18 %(V)
Flash point: 49,5 °C - closed cup
Autoignition temperature: 528 °C

Decomposition temperature: 350 °C -
pH: 2,2 at 10 g/l at 20 °C
Viscosity Viscosity, kinematic: 1,47 mm2/s at 20 °C - OECD Test
Guideline 1141,02 mm2/s at 40 °C
Viscosity, dynamic: 1,8 mPa.s at 20 °C
1141,22 mPa.s at 40 °C
Water solubility at 20 °C: miscible in all proportions, (experimental)
Partition coefficient: n-octanol/water log Pow: -2,1 at 23 °C
Vapor pressure: 171 hPa at 50 °C - OECD Test Guideline 104
Density: 1,22 g/cm3 at 20 °C - OECD Test Guideline 109
Relative density: 1,22 at 20 °C - OECD Test Guideline 109
Relative vapor density: 1,59 - (Air = 1.0)
Particle characteristics: No data available

Explosive properties: No data available
Oxidizing properties: none
Surface tension: 71,5 mN/m at 1g/l at 20 °C
Dissociation constant: 3,7 at 20 °C
Relative vapor density: 1,59 - (Air = 1.0)
Boiling point: 101 °C (1013 hPa)
Density: 1.22 g/cm3 (20 °C)
Explosion limit: 12 - 38 %(V)
Flash point: 49.5 °C
Melting Point: 8.5 °C
pH value: 2.2 (10 g/l, H₂O, 20 °C)
Vapor pressure: 171 hPa (50 °C)
Molecular Formula: CH2O2

Molar Mass: 46.03
Density: 1.22 g/mL at 25 °C (lit.)
Melting Point: 8.2-8.4 °C (lit.)
Boling Point: 100-101 °C (lit.)
Flash Point: 133°F
JECFA Number: 79
Water Solubility: MISCIBLE
Solubility H2O: soluble1g/10 mL, clear, colorless
Vapor Presure: 52 mm Hg ( 37 °C)
Vapor Density: 1.03 (vs air)
Appearance: Liquid
Specific Gravity: 1.216 (20℃/20℃)
Color APHA: ≤15



FIRST AID MEASURES of METHANOIC ACID:
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
*After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Call a physician immediately.
*After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*After swallowing:
Make victim drink water (two glasses at most).
Call a physician immediately.
Do not attempt to neutralise.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of METHANOIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully with liquid-absorbent material.



FIRE FIGHTING MEASURES of METHANOIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of METHANOIC ACID:
-Control parameters:
*Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Full contact:
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 480 min
Splash contact:
Material: Latex gloves
Minimum layer thickness: 0,6 mm
Break through time: 60 min
*Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of METHANOIC ACID:
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
No metal containers.
Keep locked up or in an area accessible only to qualified or authorized persons.
Recommended storage temperature see product label.



STABILITY and REACTIVITY of METHANOIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available



SYNONYMS:
Formic acid
Methanoic acid
Isocarbonous acid
Carbonous acid
Formylic acid
Methylic acid
Hydrogencarboxylic acid
Hydroxy(oxo)methane
Metacarbonoic acid
Oxocarbinic acid
Oxomethanol
Hydroxymethylene oxide
Ant acid
formic acid
Methanoic acid
64-18-6
Formylic acid
Aminic acid
Bilorin
Hydrogen carboxylic acid
Formisoton
Myrmicyl
Formira
Collo-bueglatt
Collo-didax
Acide formique
Add-F
Ameisensaeure
C1 acid
RCRA waste number U123
Spirit of formic acid
Formic acid (natural)
Mierenzuur
Formicum acidum
Kwas metaniowy
Acido formico
HCOOH
Ameisensaure
CCRIS 6039
Sybest
EPA Pesticide Chemical Code 214900
AI3-24237
RCRA waste no. U123
UN1779
Formic acid, dimer
Methanoic acid monomer
HCO2H
MFCD00003297
Wonderbond Hardener M 600L
0YIW783RG1
CHEBI:30751
aminate
formylate
methanoate
Formic acid [UN1779]
Formic Acid, 88%
0.1% FA in Water
hydrogen carboxylate
0.1% FA in water,
0.1% FA in ACN
0.1% FA in ACN,
0.1% Formic Acid in Water (v/v)
14523-98-9
0.1% Formic Acid in Acetonitrile (v/v)
HSDB 1646
EINECS 200-579-1
UNII-0YIW783RG1
Amasil
forrnic acid
methoic acid
icosatrienoic acids
eicosatrienoic acids
fatty acid 20:3
fatty acid 26:0
Formic acid, natural
H-COOH
Formic Acid, ACS Grade
bmse000203
EC 200-579-1
Formic acid, 95-97%
Formic acid, LC/MS Grade
Formic Acid (Fragrance Grade)
Formic acid, AR, >=90%
Formic acid, AR, >=98%
Formic acid, LR, >=85%
Formic acid, LR, >=98%
FORMICUM ACIDUM [HPUS]CHEMBL116736
Formic acid, purum, >=85%
Formic Acid (Industrial Grade)
DTXSID2024115
CHEBI:36036
CHEBI:191874
FORMIC ACID
AMY11055
BCP23013
Formic Acid Ampoules (LCMS Grade)
Formic acid, >=95%, FCC, FG
Formic acid, technical grade, 85%
Formic Acid 88% Reagent Grade ACS
Formic acid, ACS reagent, >=96%
STL264243
Formic acid, reagent grade, >=95%
VARROMED COMPONENT FORMIC ACID
AKOS000269044
Formic acid solution, 1.0M in water
Formic acid, ACS reagent, 88-91%
Water with 0.1% Formic Acid (v/v)
CCG-266004
DB01942
UN 1779
Formic acid, ACS reagent, >=96.0%
FORMIC ACID COMPONENT OF VARROMED
NCGC00248718-01
BP-21436
E236
DB-029851
C20:3
F0513
F0654
Formic acid 1000 microg/mL in Acetonitrile
Formic acid, JIS special grade, >=98.0%
Formic acid, Vetec(TM) reagent grade, 95%
FT-0626533
FT-0626535
FT-0626537
FT-0668804
C00058
Formic acid, SAJ first grade, 88.0-89.5%
Formic acid solution, BioUltra, 1.0 M in H2O
A834666
Q161233
Formic acid, p.a., ACS reagent, 98.0-100.0%
J-521387
Q27110013
F1908-0082
Add-F
Formira
Bilorin
Myrmicyl
Mierenzuur
Formisoton
Formic acid
Formic acids
acidoformico
Acido formico
kwasmetaniowy
acideformique
Ameisensaeure
Acide formique
Collo-bueglatt
methanoic acid
Kwas metaniowy
Kyselina mravenci
acideformique(french)
FormicacidAmeisensure
Hydrogen carboxylic acid


Méthénamine
N° CAS : 107-98-2,Nom INCI : METHOXYISOPROPANOL. Nom chimique : 1-methoxypropan-2-ol; propyleneglycol monomethylether. N° EINECS/ELINCS : 203-539-1. Ses fonctions (INCI); Solvant : Dissout d'autres substances. .alpha.-Propylene glycol monomethyl ether, 1-Methoxy-2-hydroxypropane, 1-methoxy-2-propanol, 1-Methoxy-2-propanol, 1-Methoxy-propane-2-ol, 1-Methoxypropan-2-ol, 1-METHOXYPROPANOL, 2-METHOXY-1-METHYLETHANOL, 2-Propanol, 1-methoxy-, 58769-19-0, ALPHA-PROPYLENE GLYCOL MONOMETHYL ETHER, Closol, DOWANOL-33B, Dowanol 33B, DOWANOL PM, Dowanol PM glycol ether, DOWTHERM 209, EINECS 203-539-1, Ether monométhylique du propylène-glycol, Glycol ether PM, LS-444, METHOXY ETHER OF PROPYLENE GLYCOL, Methoxyisopropanol, Methyl proxitol, PGME, Poly-Solve MPM, PROPASOL SOLVENT M, Propylene Glycol 1-Methyl Ether, Propylene glycol methyl ether, Propyleneglycol monomethyl ether, propylene glycol monomethyl ether, PROPYLENE GLYCOL MONOMETHYL ETHER, ALPHA, Propylenglykol-monomethylaether, PROPYLENGLYKOL-MONOMETHYLAETHER (GERMAN), UCAR SOLVENT (Obs.), Ucar Solvent LM (Obs.). Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques. Noms français : 1-METHOXY-2-HYDROXYPROPANE; 1-Methoxy-2-propanol; 2-METHOXY-1-METHYLETHANOL; 2-PROPANOL, 1-METHOXY-; ALPHA-PROPYLENE GLYCOL MONOMETHYL ETHER ETHER MONOMETHYLIQUE DE PROPYLENE GLYCOL; ETHER MONOMETHYLIQUE DU PROPYLENE GLYCOL; METHOXY-1 PROPANOL-2; Methoxyisopropanol; METHYLPROPYLENE GLYCOL; METHYLPROPYLENEGLYCOL; Éther monométhylique de propylène glycol; Éther monométhylique du propylène glycol. Noms anglais : 1-Methoxy-2-propanol;PROPYLENE GLYCOL METHYL ETHER; Propylene glycol monomethyl ether. Utilisation et sources d'émission: Solvant de produits organiques; 1-Methoxy-2-propanol ; 107-98-2 [RN]; 1-Methoxy-2-hydroxypropane 1-Methoxy-2-propanol [German] ; 1-Méthoxy-2-propanol [French] ; 1-methoxypropan-2-ol; 203-539-1 [EINECS]; 2-Propanol, 1-methoxy- [ACD/Index Name]; 74Z7JO8V3U; DOWANOL PM ; Methoxyisopropanol; Propylene glycol methyl ether ; Propylene glycol monomethyl ether; Propyleneglycol monomethyl ether; (R)-1-Methoxypropan-2-ol; (S)-1-Methoxypropan-2-ol ; 1,2-propylene glycol 1-monomethyl ether; 1-methoxy-2-propanol 95%; 1-methoxy-2-propanol 98%; 1-methoxy-2-propanol, 98.5%, extra pure; 1-methoxy-2-propanol, 99%,; 1-methoxy-2-propanol, 99+%; 2-Methoxy-1-methylethanol; 2-Propanol, methoxy-; Closol; Dowanol 33B; Dowanol PM; Dowanol-33B; Dowtherm 209; Icinol PM; methoxypropanol; Methoxypropanol, ; α isomer; Methyl proxitol; MFCD01632587 [MDL number]; MFCD01632588 [MDL number]; PGME; Propan-1-methoxy-2-ol; propan-2-ol, 1-methoxy-; Propasol solvent M; Propylene glycol 1-methyl ether; Propylenglykol-monomethylaether [German]; QY1 & 1O1 [WLN]; Solvent PM; ucar solvent LM; α-Propylene glycol monomethyl ether; 1-Methoxy-2-hydroxypropane; 1-methoxy-2-propanol; monopropylene glycol methyl ether; 1-Methoxypropanol-2; 2-Methoxy-1-methylethanol; 2-Propanol, 1-methoxy-; Closol; Dowanol 33B; Dowtherm 209; Methoxyisopropanol; Methyl proxitol; monopropylene glycol methyl ether; PGME; Poly-Solve MPM; Propasol solvent M; Propylene glycol 1-methyl ether; Propylene glycol methyl ether; Ucar Solvent LM (Obs.); 1-methoxy-2-propanol (da) 1-methoxypropaan-2-ol (nl) 1-methoxypropan-2-ol (cs) 1-metoksi-2-propanol (hr) 1-metoksi-2-propanoli (fi) 1-metoksi-2-propanolis (lt) 1-metoksi-2-propanols (lv) 1-metoksy-2-propanol (no) 1-metoksypropan-2-ol (pl) 1-metoksü-2-propanool (et) 1-metossi-2-propanol (mt) 1-metossi-2-propanolo (it) 1-metoxi-2-propanol (es) 1-metoxypropán-2-ol (sk) 1-méthoxy-2-propanol (fr) 1-μεθοξυ-προπανόλη-2 (el) 1-метокси-2-пропанол (bg) eter monometylowy glikolu propylenowego (pl) eteru tal-metil glikol monopropilen (mt) monopropilen glicol metil eter (ro) monopropilen glikol metil eter (sl) monopropilen-glikol metil-eter (hr) monopropilenglikolio metileteris (lt) monopropilén-glikol-metil-éter (hu) monopropilēnglikola metilēteris (lv) monopropyleeniglykolimetyylieetteri (fi) monopropylenglycolmethylether (da) monopropylenglykolmetyleter (no) monopropylénglykol-metyléter (sk) monopropüleenglükoolmetüüleeter (et) propilene glicol mono metil etere (it) propyleenglycolmonomethylether (nl) propylenglykolmonomethylether (cs) propylenglykolmonometyleter (no) éter metílico de monopropilenglicol (es) éter monometílico de propilenoglicol (pt) éther méthylique de monopropylèneglycol (fr) μονομεθυλαιθέρας της προπυλενογλυκόλης (el) монопропилен гликол метил етер (bg) 1-Methoxy-2-propanol (Propylene Glycol Methyl Ether) 1-methoxy-2-propanol monopropylene glycol methyl ether 1-Methoxy-2-propanol; 1-Methoxy-2-propanol; 2-Propanol, 1-methoxy-; Closol ... 1-Methoxy-propan-2-ol 1-methoxypropan-2-ol ... Propylene glycol monomethyl ether 2-propanol, 1-methoxy Agent IA94 Dowanol PM Dowanol PM - TE0036 Glycol Ether PM Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics Identification: ? 1-methoxy-2-propanol methoxy propanol methoxy-1-propanol-2 PM Solvent Propylene glycol methyl ether [PGME] (CAS 107-98-2) Propylene glycol monomethyl ether propylene glycol monomethylether Propyleneglycol monomethyl ether propyleneglycol monomethylether triphenyl phosphite Trade names 2-Propanol, 1-methoxy- (6CI, 7CI, 8CI, 9CI) Dowanol TM PM Glycol DOWANOL PM Glycol Ether METHYLPROXITOL MISSION MODELS POLYURETHANE MIX ADDITIVE ronacoat ro 304 SHP 401 SOLVENON PM
METHOXY PEG-10
Methoxy Peg-10 denotes a methylated polyethylene glycol derivative with the linear formula: CH3O(CH2CH2O)nH.
Methoxy Peg-10 with higher molecular weight is generally solid at room temperature.
Methoxy Peg-10 is a high molecular weight product that belongs to methoxy polyoxyethylene glycols.


CAS Number: 9004-74-4
MDL Number: MFCD00084416
Molecular Formula: CH3O(CH2CH2O)nH
Origin(s): Synthetic
INCI name: METHOXY PEG-10
Classification: PEG / PPG, Ethoxylated compound, Glycol, Synthetic polymer


Methoxy Peg-10 is a mono-functional methoxylated PEG (10) methacrylate monomer that features excellent wetting, water solubility, low Tg, and fast surface cure.
Methoxy Peg-10 possesses lubricity and humectant properties.


Methoxy Peg-10 maintains wet-tack strength.
Methoxy Peg-10 is a polymer with high solubility in water and a slight odour.
The active substance content in Methoxy Peg-10 is about 100%.


Methoxy Peg-10 with higher molecular weight is generally solid at room temperature.
Methoxy Peg-10 denotes a methylated polyethylene glycol derivative with the linear formula: CH3O(CH2CH2O)nH.
Methoxy Peg-10 provides enhanced solvency, lubricity, hygroscopicity and with slightly more hydrophobic solvent properties.


Methoxy Peg-10 is a high molecular weight product that belongs to methoxy polyoxyethylene glycols.
Methoxy Peg-10 is intended mainly for the construction industry.
Methoxy Peg-10 is a white compact paste or solid.


The number after "PEG-" indicates the average number of molecular units -CH2-CH2-O-, for Methoxy PEG-10 this is 10 molecular units.
Methoxy PEG derivatives are used in numerous cosmetic formulations mainly as moisturizers.
"Methoxy" refers to a methyl-oxygen group (CH3-O-).


Dimethoxy-, trimethoxy- etc refer to two, three or more methoxy groups.
"PEG" refers to a PEG-(polyethylene glycol-) derivative.
The number behind "PEG-" (or the first number behind "PEG/...-") refers to the average number of molecular units -CH2-CH2-O-.



USES and APPLICATIONS of METHOXY PEG-10:
Methoxy Peg-10 is used for use in adhesives, chemical intermediates, and lubricants.
Cosmetic Uses of Methoxy Peg-10: humectants
Methoxy Peg-10 is used in pressure-sensitive and thermoplastic adhesives.


Methoxy Peg-10 is used in pressure sensitive and thermoplastic adhesives.
Methoxy Peg-10 is recommended as a versatile intermediate for coatings and polymer modification.
Methoxy Peg-10 is used in pressure sensitive adhesives and in thermoplastic adhesives.


Methoxy Peg-10 can be used in the commercial concrete with high performance and high strength (above C60) which is mixed on site and transported remotely.
The viscosity, hygroscopicity and structure of the products can be changed by selecting products with different molecular weight.
Products with relatively low molecular weight (molecular weight less than 2000) are suitable for wetting agents and consistency regulators for cream, lotion, toothpaste, and cream.


The products with relatively high molecular weight are suitable for lipstick, deodorant stick, soap, pick up soap, foundation and cosmetics.
Methoxy Peg-10 is used in pressure sensitive and thermoplastic adhesives.
Methoxy Peg-10 is soluble in water, ethanol and organic solvent.


Low steam pressure, stable for heat, Methoxy Peg-10 is used as thickener and lubricant in textile printing and dyeing industry and daily chemical industry.
In the pharmaceutical industry, Methoxy Peg-10 is used as the matrix of ointment, emulsion, ointment, lotion and suppository.
Comb polymers, resulting from emulsion polymerization using Methoxy Peg-10, are used in paint and varnish production.


They are dispersants for organic and inorganic pigments.
Methoxy Peg-10 has good water solubility, wettability, lubricity, physiological inertia, no stimulation to human body, and is widely used in cosmetics and pharmaceutical industry.


As a cleaning agent, Methoxy Peg-10 is also used as suspending agent and thickener.
Methoxy Peg-10 is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.


Methoxy Peg-10 is used in a wide range of lubricant applications due to their low volatility, solubility in water, and natural lubricity.
Methoxy Peg-10 provides enhanced solvency, lubricity, hygroscopicity and with slightly more hydrophobic solvent properties.
Methoxy Peg-10 is used for use in adhesives, chemical intermediates, inks and dye carrier, lubricants, and soaps and detergents.


Methoxy Peg-10 is non-staining to metal parts, textiles, and clothing and can be burned away leaving minimal residue.
Methoxy Peg-10 also reacts with acrylic acid to make MPEG acrylic acid ester, which is the main raw material for the preparation of polycarboxylate superplasticizer.


Methoxy Peg-10 is mainly used for the production of polycarboxylate ether (PCE) superplasticizers for concrete.
Methoxy Peg-10 is used in esterification reactions, e.g. with methacrylic acid which is further subjected to a polymerization process.
The resulting products are the main components of concrete admixtures that reduce the amount of batch water in cement concrete.


Methoxy Peg-10 is used Adhesives-PSA, Adhesives-Waterborne, Emulsions, Paint & Coatings-Waterborne, Protective Coatings, and Water Soluble Resins
Methoxy Peg-10 is used Rubber & Elastomers, Food Processing, Packaging, Textiles, Household Products, and Wood Processing.
Methoxy Peg-10 is used Adhesives, Lubricants, Agriculture, Metalworking, Ceramics, Paints & Coatings, and Chemical Intermediates.


Methoxy Peg-10 is used Paper & Paper Products, Cosmetics & Personal Care, Pharmaceuticals, Electronics, Printing & Inks, andElectroplating / Electropolishing.


-Uses of Methoxy Peg-10:
*Adhesives
*Chemical intermediates
*Inks and dye carrier
*Lubricants
*Soaps and detergents


-Applications of Methoxy Peg-10:
*Adhesives
*Chemical Intermediates
*Inks and Dye Carrier
*Lubricants
*Plasticizer
*Soaps and Detergents


-Application of Methoxy Peg-10:
*the intermediate is used in the synthesis of superplasticizers (concrete admixtures),
*the intermediate is used in the synthesis of pigment dispersants.


-Markets and applications of Methoxy Peg-10:
*Building & Construction
*Concrete & mortar additives



FUNCTIONS OF METHOXY PEG-10:
*Humectant :
Methoxy Peg-10 maintains water content of a cosmetic both in its packaging and on the skin
Methoxy Peg-10 holds and retains moisture in cosmetic products
*Solvent :
Methoxy Peg-10 dissolves other substances
*Hydrophilicity
*Water Soluble
*Plasticizers
*Superplasticizers
*Composition
*Methoxy polyethylene glycols
*Segment
*Specialty Products / Specialty additives
*Surfactants / Non-ionic surfactants



PROPERTIES AND APPLICATIONS OF METHOXY PEG-10:
1. Applied in building materials industry, as the raw material of cement water-reducing agent, reinforcing agent.
The synthetic polycarboxylate superplasticizer of the material has strong ability of cement particle dispersion, thereof, the product is characterized of low dosage, high water-reducing rate, excellent reinforce effect, good durability, not corrosive to rebar and environmentally friendly.
Can be applied in high-performance and high strength (above C60) commodity concrete for on site agitation and long distance conveying.

2. Methoxy Peg-10 is soluble in water, ethanol and organic solvents.
Methoxy Peg-10 is used as thickener and lubricant in the textile printing and dyeing industry and daily chemical industry due to its low vapor pressure and thermal stability.



ADVANTAGES OF METHOXY PEG-10:
*effective component of PCE type superplasticizing admixtures, very good hygroscopic properties,
*low diol content,
*paste/soft wax consistency,
*high solubility in water,
*slight odour.



FEATURES OF METHOXY PEG-10:
If the refined raw material and special catalyst are used, the impurity content of the product is low.
And the hydroxyl activity at the end of the molecular chain is retained to the greatest extent, with good hydrophilicity and hydroxyl reaction activity.
Methoxy Peg-10 with higher molecular weight are generally solid at room temperature.



METHOXYPOLYETHYLENE GLYCOLS (MPEG):
Methoxypolyethylene Glycols (MPEG) are used in pharmacology and cosmetics production; detergent & household goods production (as soap bars glue, soluble agent in detergent pastes, fixing agent for odors in soaps and detergents, as additive in general cleaners, polishers, air fresheners, automatic dishwashing detergents); in production of textile supporting substances (as component of dispergators and protective solutions); in metal works industry (as agents for cleaning and polishing pastes, lubricating & cooling liquids).



PHYSICAL and CHEMICAL PROPERTIES of METHOXY PEG-10:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
InChI:InChI=1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChI key:InChIKey=XNWFRZJHXBZDAG-UHFFFAOYSA-N
SMILES:OCCOC
Molecular Formula: CH3O.(C2H4O)n.H
Molecular Weight: 700-800
CAS Number: 9004-74-4
EINECS/ELINCS: None Properties
Appearance: White to light yellow paste
Melting Point: 52-56°C
Density at 25ºC: 1.094 g/ml at 25 °C

Solubility in water: Soluble
Stability: Stable under ordinary conditions
Physical state: flakes
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 52 - 56 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point 182 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 5,08 at 25 °C
(as aqueous solution)

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility at 20 °C slightly soluble
Partition coefficient:
n-octanol/water: No data available
Vapor pressure: No data available
Density: ca.1,094 g/cm3
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: nonenone
Other safety information: No data available
Appearance: White to light yellow paste
Hydroxyl value: 70.0-80.0mgKOH/g
Molecular weight: 700-800
Water: 0.50% max
PH(1%): 5.0-7.0



FIRST AID MEASURES of METHOXY PEG-10:
-Description of first aid measures:
*General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Flush eyes with water as a precaution.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of METHOXY PEG-10:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of METHOXY PEG-10:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of METHOXY PEG-10:
-Control parameters:
--Exposure controls:
-Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
--Personal protective equipment:
*Eye/face protection:
Safety glasses with side-shields.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of METHOXY PEG-10:
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of METOKSİ PEG-10:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
2-methoxyethanol (peg-10)
CARBOWAX MPEG 550
METOKSİ PEG-10
METOKSİ PEG-10 [INCI]
MPEG-10
PEG-10 METHYL ETHER
POLYETHYLENE GLYCOL 500 MONOMETHYL ETHER
POLYETHYLENE GLYCOL MONOMETHYL ETHER (MW 470) POLYOXYETHY LENE
(10) MONOMETHYL ETHER


METHOXY PEG-16
Methoxy Peg-16 provides enhanced solvency, lubricity, hygroscopicity and with slightly more hydrophobic solvent properties.
Methoxy Peg-16 is a polymer with high solubility in water and a slight odour.


CAS Number: 9004-74-4
Chem/IUPAC Name: Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-methoxy- (16 mol EO average molar ratio)
MDL number: MFCD00084416
Classification: PEG / PPG, Ethoxylated compound, Glycol, Synthetic polymer


Methoxy Peg-16 provides enhanced solvency, lubricity, hygroscopicity and with slightly more hydrophobic solvent properties.
Methoxy Peg-16 is a white compact paste or solid.
Methoxy Peg-16 is a polymer with high solubility in water and a slight odour.


The active substance content in Methoxy Peg-16 is about 100%.
Methoxy Peg-16 is a mono-functional methoxylated PEG (16) methacrylate monomer that features excellent wetting, water solubility, low Tg, and fast surface cure.


Methoxy Peg-16 maintains wet-tack strength.
Methoxy Peg-16 is a high molecular weight product that belongs to methoxy polyoxyethylene glycols.
Methoxy Peg-16 is intended mainly for the construction industry.


Methoxy Peg-16 with higher molecular weight is generally solid at room temperature.
Methoxy Peg-16 denotes a methylated polyethylene glycol derivative with the linear formula: CH3O(CH2CH2O)nH.


Methoxy Peg-16 provides enhanced solvency, lubricity, hygroscopicity and with slightly more hydrophobic solvent properties.
Methoxy Peg-16 possesses lubricity and humectant properties.


The number after "PEG-" indicates the average number of molecular units -CH2-CH2-O-, for Methoxy PEG-10 this is 10 molecular units.
Methoxy PEG derivatives are used in numerous cosmetic formulations mainly as moisturizers.
"Methoxy" refers to a methyl-oxygen group (CH3-O-).


Dimethoxy-, trimethoxy- etc refer to two, three or more methoxy groups.
"PEG" refers to a PEG-(polyethylene glycol-) derivative.
The number behind "PEG-" (or the first number behind "PEG/...-") refers to the average number of molecular units -CH2-CH2-O-.



USES and APPLICATIONS of METHOXY PEG-16:
Methoxy Peg-16 is used for use in adhesives, chemical intermediates, and lubricants​​.
Methoxy Peg-16 is recommended as a versatile intermediate for coatings and polymer modification.
Methoxy Peg-16 is used in pressure sensitive adhesives and in thermoplastic adhesives.


Methoxy Peg-16 can be used in the commercial concrete with high performance and high strength (above C60) which is mixed on site and transported remotely.
Methoxy Peg-16 also reacts with acrylic acid to make MPEG acrylic acid ester, which is the main raw material for the preparation of polycarboxylate superplasticizer.


Methoxy Peg-16 is mainly used for the production of polycarboxylate ether (PCE) superplasticizers for concrete.
Methoxy Peg-16 is used in esterification reactions, e.g. with methacrylic acid which is further subjected to a polymerization process.
The resulting products are the main components of concrete admixtures that reduce the amount of batch water in cement concrete.


Methoxy Peg-16 is used in pressure sensitive and thermoplastic adhesives.
Comb polymers, resulting from emulsion polymerization using Methoxy Peg-16, are used in paint and varnish production.
As a cleaning agent, Methoxy Peg-16 is also used as suspending agent and thickener.


In the pharmaceutical industry, Methoxy Peg-16 is used as the matrix of ointment, emulsion, ointment, lotion and suppository.
They are dispersants for organic and inorganic pigments.
Methoxy Peg-16 is used Adhesives-PSA, Adhesives-Waterborne, Emulsions, Paint & Coatings-Waterborne, Protective Coatings, and Water Soluble Resins


Methoxy Peg-16 is used Rubber & Elastomers, Food Processing, Packaging, Textiles, Household Products, and Wood Processing.
Methoxy Peg-16 is used Paper & Paper Products, Cosmetics & Personal Care, Pharmaceuticals, Electronics, Printing & Inks, andElectroplating / Electropolishing.


Methoxy Peg-16 is used Adhesives, Lubricants, Agriculture, Metalworking, Ceramics, Paints & Coatings, and Chemical Intermediates.
Methoxy Peg-16 provides enhanced solvency, lubricity, hygroscopicity and with slightly more hydrophobic solvent properties.
Methoxy Peg-16 is used for use in adhesives, chemical intermediates, inks and dye carrier, lubricants, and soaps and detergents.


Methoxy Peg-16 is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.
Methoxy Peg-16 is used in a wide range of lubricant applications due to their low volatility, solubility in water, and natural lubricity.


Methoxy Peg-16 is non-staining to metal parts, textiles, and clothing and can be burned away leaving minimal residue.
Methoxy Peg-16 is used in pressure sensitive and thermoplastic adhesives.
Methoxy Peg-16 is soluble in water, ethanol and organic solvent.


Low steam pressure, stable for heat, Methoxy Peg-16 is used as thickener and lubricant in textile printing and dyeing industry and daily chemical industry.
Methoxy Peg-16 is used for use in adhesives, chemical intermediates, and lubricants.
Cosmetic Uses of Methoxy Peg-16: humectants


Methoxy Peg-16 is used in pressure-sensitive and thermoplastic adhesives.
Methoxy Peg-16 has good water solubility, wettability, lubricity, physiological inertia, no stimulation to human body, and is widely used in cosmetics and pharmaceutical industry.


The viscosity, hygroscopicity and structure of the products can be changed by selecting products with different molecular weight.
Products with relatively low molecular weight (molecular weight less than 2000) are suitable for wetting agents and consistency regulators for cream, lotion, toothpaste, and cream.
The products with relatively high molecular weight are suitable for lipstick, deodorant stick, soap, pick up soap, foundation and cosmetics.


-Application of Methoxy Peg-16:
*the intermediate is used in the synthesis of superplasticizers (concrete admixtures),
*the intermediate is used in the synthesis of pigment dispersants.


-Markets and applications of Methoxy Peg-16:
*Building & Construction
*Concrete & mortar additives


-Applications of Methoxy Peg-16:
*Adhesives
*Chemical Intermediates
*Inks and Dye Carrier
*Lubricants
*Plasticizer
*Soaps and Detergents


-Uses of Methoxy Peg-16:
*Adhesives
*Chemical intermediates
*Inks and dye carrier
*Lubricants
*Soaps and detergents



PROPERTIES AND APPLICATIONS OF METHOXY PEG-16:
1. Applied in building materials industry, as the raw material of cement water-reducing agent, reinforcing agent.
The synthetic polycarboxylate superplasticizer of the material has strong ability of cement particle dispersion, thereof, the product is characterized of low dosage, high water-reducing rate, excellent reinforce effect, good durability, not corrosive to rebar and environmentally friendly.
Can be applied in high-performance and high strength (above C60) commodity concrete for on site agitation and long distance conveying.

2. Methoxy Peg-16 is soluble in water, ethanol and organic solvents.
Methoxy Peg-16 is used as thickener and lubricant in the textile printing and dyeing industry and daily chemical industry due to its low vapor pressure and thermal stability.



ADVANTAGES OF METHOXY PEG-16:
*effective component of PCE type superplasticizing admixtures, very good hygroscopic properties,
*low diol content,
*paste/soft wax consistency,
*high solubility in water,
*slight odour.



FUNCTIONS OF METHOXY PEG-16:
*Humectant :
Methoxy Peg-16 maintains water content of a cosmetic both in its packaging and on the skin
Methoxy Peg-16 holds and retains moisture in cosmetic products
*Solvent :
Methoxy Peg-16 dissolves other substances
*Hydrophilicity
*Water Soluble
*Plasticizers
*Superplasticizers
*Composition
*Methoxy polyethylene glycols
*Segment
*Specialty Products / Specialty additives
*Surfactants / Non-ionic surfactants



FEATURES OF METHOXY PEG-16:
If the refined raw material and special catalyst are used, the impurity content of the product is low.
And the hydroxyl activity at the end of the molecular chain is retained to the greatest extent, with good hydrophilicity and hydroxyl reaction activity.
Methoxy Peg-16 with higher molecular weight are generally solid at room temperature.



METHOXYPOLYETHYLENE GLYCOLS (MPEG):
Methoxypolyethylene Glycols (MPEG) are used in pharmacology and cosmetics production; detergent & household goods production (as soap bars glue, soluble agent in detergent pastes, fixing agent for odors in soaps and detergents, as additive in general cleaners, polishers, air fresheners, automatic dishwashing detergents); in production of textile supporting substances (as component of dispergators and protective solutions); in metal works industry (as agents for cleaning and polishing pastes, lubricating & cooling liquids).



PHYSICAL and CHEMICAL PROPERTIES of METHOXY PEG-16:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
InChI:InChI=1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChI key:InChIKey=XNWFRZJHXBZDAG-UHFFFAOYSA-N
SMILES:OCCOC
Molecular Formula: CH3O.(C2H4O)n.H
Molecular Weight: 700-800
CAS Number: 9004-74-4
EINECS/ELINCS: None Properties
Appearance: White to light yellow paste
Melting Point: 52-56°C
Density at 25ºC: 1.094 g/ml at 25 °C

Solubility in water: Soluble
Stability: Stable under ordinary conditions
Physical state: flakes
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 52 - 56 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point 182 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 5,08 at 25 °C
(as aqueous solution)

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility at 20 °C slightly soluble
Partition coefficient:
n-octanol/water: No data available
Vapor pressure: No data available
Density: ca.1,094 g/cm3
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: nonenone
Other safety information: No data available
Appearance: White to light yellow paste
Hydroxyl value: 70.0-80.0mgKOH/g
Molecular weight: 700-800
Water: 0.50% max
PH(1%): 5.0-7.0



FIRST AID MEASURES of METHOXY PEG-16:
-Description of first aid measures:
*General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Flush eyes with water as a precaution.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of METHOXY PEG-16:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of METHOXY PEG-16:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of METHOXY PEG-16:
-Control parameters:
--Exposure controls:
-Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
--Personal protective equipment:
*Eye/face protection:
Safety glasses with side-shields.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of METHOXY PEG-16:
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.



STABILITY and REACTIVITY of METHOXY PEG-16:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available



SYNONYMS:
Methoxy PEG-16
89ES36762B
CARBOWAX MPEG 750
MPEG-16
PEG-16 METHYL ETHER
POLYETHYLENE GLYCOL MONOMETHYL ETHER (MW 750)
CARBOWAX MPEG 750
METHOXY PEG-16
METHOXY PEG-16 [INCI]
MPEG-16
PEG-16 METHYL ETHER
POLYETHYLENE GLYCOL (16) MONOMETHYL ETHER
POLYETHYLENE GLYCOL MONOMETHYL ETHER (MW 750)
POLYOXYETHY LENE (16) MONOMETHYL ETHER

METHOXY POLYETHYLENE GLYCOL
Methoxy polyethylene glycol belong to a type of polyethylene glycols (PEG) containing methoxy groups in their structure.
Methoxy polyethylene glycol is a synthetic polymer of ethylene oxide which, after reacting with methyl ether, gains a functional group with the formula -OCH3.
Methoxy polyethylene glycol is a polymer similar in structure and nomenclature to polyethylene glycols.

CAS Number: 9004-74-4
Molecular Formula: C5H12O3
Molecular Weight: 120.14698
EINECS Number: 618-394-3

Methoxy polyethylene glycol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
The hydrophilic PEG spacer increases solubility in aqueous media.
Methoxy polyethylene glycol is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether.

Etherification of the Methoxy polyethylene glycol chain ends can be undertaken in basic conditions by reacting it with alkyl halides.
Methoxy polyethylene glycol can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.
Methoxy polyethylene glycol, sold under the brand name Mircera, is a long-acting erythropoietin receptor activator (CERA) used for the treatment of anaemia associated with chronic kidney disease.

Methoxy polyethylene glycol is the first approved, chemically modified erythropoiesis-stimulating agent (ESA).
Methoxy polyethylene glycol is on the World Health Organization's List of Essential Medicines.
Methoxy polyethylene glycol was approved for medical use in the European Union, Switzerland,[citation needed] and the United States in 2007.

Methoxy polyethylene glycol is made from erythropoietin by chemically linking the N-terminal amino group or the ε-amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid.
The average molecular weight is approximately 60 kDa.
The drug stimulates erythropoiesis by interacting with the erythropoietin receptor on progenitor cells in the bone marrow.

Methoxy polyethylene glycol has a reduced receptor binding activity compared to other ESAs and but retains in vivo activity due to an extended serum half-life.
Methoxy polyethylene glycol has an in vivo half-life of around 135 hours (5.6 days) as compared to darbepoetin alfa which has a half life of around 21 to 70 hours, the half life of which is three times that of the naturally occurring erthropoietin in the body.
Methoxy polyethylene glycol contains the active substance methoxy polyethylene glycol epoetin beta, and is a medicine that stimulates the growth of red blood cells.

Methoxy polyethylene glycol is indicated for the treatment of symptomatic anaemia associated with chronic kidney disease (CKD) in adult patients.
Methoxy polyethylene glycol is given by subcutaneous or intravenous injections, using a pre-filled syringe.
Methoxy polyethylene glycol is also a recombinant product.

Methoxy polyethylene glycol has been chemically modified and has different activity to erythropoietin at the receptor level it associates with the receptor more slowly, but dissociates faster.
Methoxy polyethylene glycol has a much longer half-life than erythropoietin and does not need to be given as often.
After subcutaneous administration, maximum serum concentrations are reached after 72 hours.

The elimination half-life is 139 hours after a subcutaneous injection and 134 hours after an intravenous injection.
Methoxy polyethylene glycol is has no effect on serum concentrations of this drug.
Methoxy polyethylene glycol (given subcutaneously every two weeks) was non-inferior to darbepoetin alfa (given weekly).

Almost all patients (98% with methoxy polyethylene glycol-epoetin beta, 96% with darbepoetin alfa) had responded to treatment by 28 weeks.
Methoxy polyethylene glycol can be given subcutaneously or intravenously.
Subcutaneous injections can be given in the abdomen, arm or thigh.

The starting dose and the dosing frequency of this drug depend on whether the patient is already receiving erythropoietin or is starting treatment.
Methoxy polyethylene glycol information explains how to calculate the dose if a patient is switching from another erythropoietin.
In treatment-nave patients, the recommended dose is 0.6 microgram/kg every two weeks initially.

Methoxy polyethylene glycol seems to be as effective as other epoetins for correcting and maintaining haemoglobin concentrations in patients with renal anaemia.
Methoxy polyethylene glycol is used to treat anemia caused by kidney failure.
Methoxy polyethylene glycol injection causes the bone marrow to produce red blood cells.

If the body does not produce enough red blood cells, severe anemia can occur. This often occurs in people with chronic kidney failure whose kidneys are not working properly.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
Methoxy polyethylene glycol is a member of the polyethylene glycol family, and its properties can be fine-tuned by adjusting parameters such as molecular weight and the degree of methoxylation.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Methoxy polyethylene glycol injection in children 5 to 17 years of age when it is given through a needle placed into one of your child's veins.
Safety and efficacy have not been established in children younger than 5 years of age or when it is given as a shot under the skin in children.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methoxy polyethylene glycol-epoetin beta injection in the elderly.

However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution or an adjustment in the dose in patients receiving this medicine.
Methoxy polyethylene glycol helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.
Methoxy polyethylene glycol is given as a single injection under your skin.

Methoxy polyethylene glycol is a type of polyethylene glycol (PEG) that has methoxy groups attached to its molecular structure.
Methoxy polyethylene glycols are a family of synthetic polymers that consist of repeating units of ethylene glycol.
They are water-soluble, biocompatible, and have a wide range of applications in various industries, including pharmaceuticals, cosmetics, and food.

The addition of Methoxy polyethylene glycol can alter its properties, making it more hydrophobic (water-repellent) compared to traditional PEG.
This modification is often employed to fine-tune the solubility, stability, and other characteristics of the polymer for specific applications.
In the pharmaceutical industry, Methoxy polyethylene glycol is frequently used in the formulation of certain drug products, particularly in the development of extended-release or sustained-release formulations.

Methoxy polyethylene glycol can also be used to enhance the solubility of poorly water-soluble drugs, improve drug stability, and reduce immunogenicity.
The molecular weight of Methoxy polyethylene glycol can vary, and different molecular weights can be selected based on the specific requirements of a given application.
Molecular weight influences the physical and chemical properties of the polymer.

Methoxy polyethylene glycols, in general, are known for their hydrophilic (water-attracting) nature.
The addition of methoxy groups to Methoxy polyethylene glycol imparts a degree of hydrophobicity, allowing MPEG to have a balance between hydrophilicity and hydrophobicity.
This balance is crucial in applications where controlled release, stability, and solubility in both aqueous and organic media are important.

Methoxy polyethylene glycol is commonly used in the pharmaceutical industry for drug delivery applications.
Methoxy polyethylene glycol can be conjugated to drugs or used as part of a drug delivery system to modify the pharmacokinetics and biodistribution of the drug.
For instance, Methoxy polyethylene glycol can enhance the circulation time of drugs in the bloodstream, reduce immunogenicity, and improve the overall therapeutic profile.

Methoxy polyethylene glycol can be used for surface modifications of materials to alter their properties.
For example, Methoxy polyethylene glycol might be employed in coatings for medical devices or nanoparticles to improve their biocompatibility and reduce interactions with biological components.
Methoxy polyethylene glycol can be conjugated to other polymers or molecules to create copolymers with specific properties.

This is often done to achieve a desired combination of characteristics such as stability, solubility, and controlled release.
Methoxy polyethylene glycol is also used in cosmetic and personal care products.
Methoxy polyethylene glycol is water-solubility makes it suitable for formulations like creams, lotions, and shampoos, where it can serve as a thickening or emulsifying agent.

Melting point: 60-64 °C
Boiling point: >200°C/760mmHg
Density: 1.094 g/mL at 25 °C
vapor density: >1 (vs air)
vapor pressure: 0.05 mm Hg ( 20 °C)
refractive index: n20/D 1.459
Flash point: 268 °C
storage temp.: -20°C
solubility: H2O: 50 mg/mL at 25 °C, clear, colorless
form: semisolid
Specific Gravity: 1.094
color: White to pale yellow
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility: Slightly miscible with water.
λmax: λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.03
Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
LogP: -0.800 (est)

Methoxy polyethylene glycol is a growth factor for erythroid development.
Methoxy polyethylene glycol is produced in the kidney and released into the bloodstream in response to hypoxia, interacting with erythroid progenitor cells to increase red blood cell production.
Production of endogenous erythropoietin is impaired in patients with chronic kidney disease (CKD), and erythropoietin deficiency is the primary cause of their anaemia.

Administration of Methoxy polyethylene glycol acts like endogenous erythropoetin and stimulates erythropoetin receptor of the erythroid progenitor cells in the bone marrow.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
Methoxy polyethylene glycol is an erythropoiesis-stimulating agent (ESA), which stimulates erythropoiesis by the same mechanism as endogenous erythropoietin.

Methoxy polyethylene glycol is indicated for the treatment of anemia associated with chronic kidney disease (CKD in adult patients on dialysis and patients not on dialysis).
Methoxy polyethylene glycol injection is used to treat anemia (a lower than normal number of red blood cells) in people with chronic kidney failure (condition in which the kidneys slowly and permanently stop working over a period of time) in adults on and not on dialysis and in children 5 years of age and older on dialysis who have already received another treatment for anemia.

Methoxy polyethylene glycol injection should not be used to treat anemia caused by cancer chemotherapy and should not be used in place of a red blood cell transfusion to treat severe anemia.
Methoxy polyethylene glycol injection is in a class of medications called erythropoiesis-stimulating agents (ESAs).
Methoxy polyethylene glycol works by causing the bone marrow (soft tissue inside the bones where blood is made) to make more red blood cells.

For the treatment of patients with anaemia associated with chronic kidney disease.
Not a substitute for RBC transfusion if immediate correction of anemia is required.
Stimulates hemoglobin production by stimulating the erythropoetin receptor of erythroid progenitor cells in the bone marrow.

Hemoglobin increase, following a single initial dose, occurs 7 to 15 days after.
Treatment with Mircera should be started under the supervision of a doctor who has experience in the management of patients with kidney disease.
Methoxy polyethylene glycol is given as an injection under the skin or into a vein.

The dose and the frequency of dosing depend on whether or not Methoxy polyethylene glycol is replacing another medicine used to stimulate the production of red blood cells.
Doses should be adjusted according to the patient’s response.
Methoxy polyethylene glycol is intended for long-term use.

Adult patients can inject themselves once they have been trained appropriately.
Methoxy polyethylene glycol should be given to children by a healthcare professional or by an adult caregiver who has been appropriately trained.
Patients with chronic kidney disease may not produce enough erythropoietin, a hormone that stimulates the production of red blood cells.

The active substance in Methoxy polyethylene glycol, methoxy polyethylene glycol-epoetin beta, works like natural erythropoietin to stimulate red blood cell production, because it can attach itself to the same receptors (targets) as erythropoietin.
However, the way it interacts with the receptor is slightly different from natural erythropoietin, which gives it a longer effect.
Methoxy polyethylene glycol is also cleared from the body less quickly.

As a result, Methoxy polyethylene glycol can be given less often than natural erythropoietin.
Methoxy polyethylene glycol was shown to be as effective as the comparator medicines in correcting and maintaining haemoglobin levels in six main studies involving a total of 2,399 adults with anaemia associated with chronic kidney disease. Mircera was compared with other medicines used to stimulate red blood cell production.
In all six studies, the main measure of effectiveness was the change in haemoglobin levels.

Most patients also received iron to prevent deficiency (low iron levels) during the studies.
Methoxy polyethylene glycol, which involves attaching PEG chains to various biological molecules such as proteins or peptides, is a common application of Methoxy polyethylene glycol in biotechnology.
This modification is often used to improve the stability, solubility, and pharmacokinetics of therapeutic proteins, making them more suitable for pharmaceutical use.

Methoxy polyethylene glycol in Nanotechnology: MPEG is frequently employed in the development of polymeric nanoparticles and micelles for drug delivery.
These nanoparticles can encapsulate drugs and improve their bioavailability, as well as provide targeted delivery to specific tissues or cells.
Methoxy polyethylene glycol, including the use of MPEG, is known to reduce the immunogenicity of certain therapeutic agents.

The addition of Methoxy polyethylene glycol can help evade the immune system, preventing the rapid clearance of the therapeutic agent from the body.
Methoxy polyethylene glycol has been utilized in various therapeutic applications, including the treatment of conditions such as cancer and autoimmune diseases.
Methoxy polyethylene glycol drugs may have prolonged circulation times, allowing for less frequent dosing and potentially reducing side effects.

Methoxy polyethylene glycol and MPEG have generally been considered safe and well-tolerated in many applications, it's essential to consider potential toxicity concerns.
High molecular weight PEGs, in particular, may have different safety profiles, and the accumulation of PEG in the body over time has been a topic of research.
The chemical structure of Methoxy polyethylene glycol includes the methoxy (-OCH3) groups attached to the ethylene glycol units.

Methoxy polyethylene glycol, various PEG derivatives with different functional groups and modifications exist.
These derivatives can be tailored for specific applications, offering versatility in the design of polymers with diverse properties.
The use of Methoxy polyethylene glycol, especially in the pharmaceutical and medical fields, is subject to regulatory considerations.

Uses:
Methoxy polyethylene glycol has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Methoxy polyethylene glycol has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Methoxy polyethylene glycol of with an average molecular mass of 350.

Methoxy polyethylene glycol is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.
Methoxy polyethylene glycol beta injection is used to treat anemia in adults with chronic kidney disease (CKD) who may or may not be on dialysis or in children with CKD who are on dialysis.
This medicine is not used to treat anemia caused by cancer medicines.

Methoxy polyethylene glycol is a medicine used to treat the symptoms of anaemia (low levels of red blood cells) in adults and children aged 3 months and older with chronic kidney disease (long-term, progressive decrease in the ability of the kidneys to work properly).
Methoxy polyethylene glycol may be used in the formulation of adhesives and sealants, contributing to their stability and performance.
In the textile industry, Methoxy polyethylene glycols, including MPEG, can be used as finishing agents to impart certain properties to fabrics, such as softness and wrinkle resistance.

Methoxy polyethylene glycol can be employed in various chemical processes as a reaction medium or as a stabilizing agent for certain reactions.
Methoxy polyethylene glycols, including MPEG, have historically been used in the photographic industry as ingredients in film coatings and processing solutions.
Methoxy polyethylene glycols are used as de-icing agents, especially in aviation, to prevent the formation of ice on the surfaces of aircraft.

Methoxy polyethylene glycols may be used in the formulation of lubricants to improve their properties and performance.
Methoxy polyethylene glycol can be utilized in the synthesis of various polymers, contributing to the development of materials with specific properties.
Methoxy polyethylene glycols, including MPEG, are used in the field of art conservation for the treatment of wooden artifacts and objects to prevent drying and cracking.

In some medical applications, PEGs like Methoxy polyethylene glycol may be included in wound care products to provide moisture and aid in the healing process.
Methoxy polyethylene glycols can be used in agriculture as components in certain formulations, such as in crop protection products.
Methoxy polyethylene glycol beta is a synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease.

Methoxy polyethylene glycol beta injection is used to treat anemia in adults with chronic kidney disease (CKD) who may or may not be on dialysis or in children with CKD who are on dialysis.
This medicine is not used to treat anemia caused by cancer medicines.
Methoxy polyethylene glycol is often used in drug delivery systems to modify the pharmacokinetics of drugs.

Methoxy polyethylene glycol can improve the solubility of poorly water-soluble drugs and enhance their bioavailability.
In biopharmaceuticals, PEGylation with compounds like Methoxy polyethylene glycol is employed to modify proteins, enzymes, and peptides.
This modification can improve the stability and circulation time of these therapeutic agents in the body.

Methoxy polyethylene glycol is used in biotechnological processes to modify proteins and enzymes, improving their stability and performance.
Methoxy polyethylene glycol is commonly used in the development of polymeric nanoparticles and micelles for drug delivery.
These nanoparticles can encapsulate drugs and improve their delivery to target tissues.

Due to its water-soluble nature, Methoxy polyethylene glycol is used as an emulsifying and solubilizing agent in cosmetic and personal care products such as creams, lotions, and shampoos.
Methoxy polyethylene glycol can be used to modify the surface properties of materials, including medical devices and nanoparticles, to enhance biocompatibility.
Methoxy polyethylene glycol can be used to form copolymers with other polymers, influencing the overall properties of the resulting material.

This is often done to achieve specific characteristics in drug delivery systems.
Methoxy polyethylene glycol, may find applications in the food industry as additives or stabilizers.
Methoxy polyethylene glycol is used in laboratories as a reagent in various research applications.

Methoxy polyethylene glycol has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Methoxy polyethylene glycol has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.

Safety Profile:
Methoxy polyethylene glycol can have toxicity concerns, especially at higher concentrations or with prolonged exposure.
The extent of toxicity may depend on factors such as molecular weight, degree of methoxylation, and the specific application.
Concentrated solutions or direct contact with Methoxy polyethylene glycol can cause skin and eye irritation.

Proper protective measures, such as gloves and goggles, should be used when handling this substance.
Inhalation of dust or vapors from Methoxy polyethylene glycol may cause respiratory irritation.
Adequate ventilation should be provided in areas where this substance is handled, and respiratory protection may be necessary in certain situations.

Methoxy polyethylene glycol, have been associated with allergic reactions in some individuals.
Sensitivity can vary, and individuals with known allergies to Methoxy polyethylene glycol should exercise caution.
Methoxy polyethylene glycol and other polyethylene glycols should be in accordance with environmental regulations.

Synonyms:
Triglyme
112-49-2
2,5,8,11-TETRAOXADODECANE
Triethylene glycol dimethyl ether
1,2-Bis(2-methoxyethoxy)ethane
Glyme 4
Ansul ether 161
Glyme-3
1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
Dimethyl ether of triethylene glycol
Ethane, 1,2-bis(2-methoxyethoxy)-
NSC 66400
DTXSID8026224
1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE
32YXG88KK0
triethyleneglycol dimethyl ether
CHEBI:44842
NSC-66400
TEGDIME
PG5
EINECS 203-977-3
Glycol, triethylene-, dimethyl ether
BRN 1700630
UNII-32YXG88KK0
AI3-28582
Glyme-4
1,2-Bis(2-methoxyethoxy) Ethane, Reagent
TRIGLYME [MI]
2,8,11-Tetraoxadodecane
EC 203-977-3
SCHEMBL16126
1,2-Bis(methoxyethoxy)ethane
triethylene glycol dimethylether
DTXCID206224
CHEMBL1235255
Triethylene glycol dimethyl ether (stabilized with BHT)
Ethane,2-bis(2-methoxyethoxy)-
(CH3O(CH2)2OCH2)2
NSC66400
Tox21_300509
MFCD00008504
AKOS009158244
CS-W017328
DB02078
NCGC00164017-01
NCGC00164017-02
NCGC00254323-01
CAS-112-49-2
B0496
FT-0659858
FT-0755020
EN300-40253
E75964
A802587
1-Methoxy-2-[2-(2-methoxy-ethoxy)-ethoxy]-ethane
Q2453066
Triethylene glycol dimethyl ether, ReagentPlus(R), 99%
Z409380232
Triethylene glycol dimethyl ether 100 microg/mL in Acetonitrile
Triethylene glycol dimethyl ether, analytical reference material
Triethylene glycol dimethyl ether, Vetec(TM) reagent grade, 98%
2,5,8,11-tetraoxadodecane;1,2-bis(2-methoxyethoxy)ethane;triethylene glycol dimethyl ether;1,2bis(2methoxyethoxy)ethane;triethylene glycoldimethylether (tegdme);2,5,8,11-tetraoxadodecane 1,2-bis(2-methoxyethoxy)ethane triethylene glycol dimethyl ether 1,2bis(2methoxyethoxy)ethane triethylene glycoldimethylether (tegdme)
METHOXY POLYETHYLENE GLYCOL 1000
MPEG 1000
Polyglykol M 1000
Methyl polyglycol
Monomethoxy polyethylene glycol 1000
Methoxy Polyethylene Glycol 1000
CARBOWAX Methoxypolyethylene Glycol (MPEG)
Carbowax MPEG 1000
mpeg 1000

Synonyms: MPEG 1000, mPEG 1000, Polyglykol M 1000, Monomethoxy polyethylene glycol 1000, Methoxy PEG-25, Methoxy Polyethylene Glycol 1000, Methyl polyglycol 1000, POLYETHYLENE GLYCOL MONOMETHYL ETHER, Polyethylenglykolmonomethylether 1000, CARBOWAX Methoxypolyethylene Glycol (MPEG) 1000




Composition
Monomethoxy polyethylene glycol 1000

Molecular Structure: CH3(OCH2CH2)nOH

EC / List no.: 618-394-3

CAS no.: 9004-74-4

INCI-designation: Methoxy PEG-25


PRODUCT FUNCTION: Intermediate & process aid

CHEMICAL TYPE: Methoxy Polyethylene glycol 1000


APPLICATIONS of Methoxy Polyethylene Glycol 1000
Chemical synthesis
Concrete Admixture
Construction
Dry mix mortars
General industrial applications
Grinding Aids
Industrial Lubrication
Lubes and Greases
Paint additive manufacturing
Paint additive manufacturing
Plaster Boards
Plastic & elastomer synthesis
Resin synthesis
Superplasticizer



Applications of Methoxy Polyethylene Glycol 1000:
Methoxy Polyethylene Glycol 1000 is a raw material for 3rd generation superplasticizers.

Methoxy Polyethylene Glycol 1000 is an effective component of PCE superplasticizer admixtures.

Methoxy Polyethylene Glycol 1000 is an intermediate in synthesizing superplasticizers (concrete admixtures) and pigment dispersants.

Methoxy Polyethylene Glycol 1000 is used as a raw material in producing polycarboxylate ether superplasticizers.

The polycarboxylic acid superplasticizer is prepared with acrylic acid, Methoxy Polyethylene Glycol 1000, and sodium vinyl sulfonate, and through the esterification of acrylic acid and Methoxy Polyethylene Glycol 1000 in the water bath to prepare intermediate polyglycol acrylate, and the subsequent free radical polymerization of polyglycol acrylate, sodium vinyl sulfonate, and acrylic acid under the action of initiator in water solution.

The preparation process has easily controlled conditions, simple operation, no pollution, low cost, and other features.
The product of the present invention may be used as a concrete superplasticizer suitable for different kinds of cement.


Methoxy polyethylene glycol ether with a molecular weight of 1000 g/mole is commonly used as a chemical intermediate in producing alkyd emulsions and HEUR thickeners.

Methoxy Polyethylene Glycol 1000 is used for a wide variety of chemical reactions.

Methoxy Polyethylene Glycol 1000 acts as end-capping and hydrophilic components with isocyanates and polyester

When Methoxy Polyethylene Glycol 1000 is reacted with unsaturated monomers like acrylic or methacrylic acid, esters are formed, which can be copolymerized to increase hydrophilicity and improve the dispersing properties of polymers in water.

Methoxy polyethylene Glycol (MPEG) 1000 is used in pressure-sensitive and thermoplastic adhesives.
Methoxy Polyethylene Glycol 1000 possesses lubricity & humectant properties and maintains wet-tack strength

Due to the low concentration of diols in poly-glycol M-types, almost no di-esters form during the reaction with acrylic or methacrylic acid.
In the USA, some M-type polyglycols are used for pharmaceutical applications.



Product properties*)
Methoxy Polyethylene Glycol 1000 is a waxy white to slightly yellowish solid at room temperature.

Methoxy Polyethylene Glycol 1000 can be supplied as melt in heated tank trucks or solid in steel drums.

Methoxy Polyethylene Glycol 1000 is soluble in water and solvents like acetate and methanol.

Methoxy Polyethylene Glycol 1000 can be considered a high molecular alcohol and, therefore, displays typical chemical reactions of alcohols.


Methoxy Polyethylene Glycol 1000 is a linear, mono hydroxy-functional polyethylene glycol monomethyl ether (M-PEG) that is entirely water-soluble.


Methoxy Polyethylene Glycol 1000 PRODUCT FUNCTION: Intermediate


Product data*)
Water content (DIN 51777) % w/w: max. 0.1
Color Hazen (10% w/w in water) (EN 1557): max. 30
pH (5 %i w/w in water) (DIN 19268): 5,0 – 7,0
Hydroxyl number (DIN 53240) mg KOH/g: 53 - 58
Molecular weight g/mol: 970 - 1060
Pour point (ISO 3016) °C: ca. 40
Viscosity at 20°C (50% w/w in water) (DIN 51562) mm²/s: about 27
Diol content (HPLC) area-%: 0,5 – 2,0





Item Specification Unit Method

Consistence at 20°C wax-like Ataman
visual

Hazen color 10% a.i. in water max. 30 EN 1557

pH value 5% in water: 5.0 - 7.0 DIN EN 1262

Water content: max. 0.1 % DIN 51777
Karl-Fischer

OH value: 53 - 58 mgKOH/g DIN 53240

Molar mass: 970 - 1060 g/mol Ataman
calculated of OH value

Diole content: max. 2.0 area-% Ataman
HPLC



Storage
When stored in a cold, dry place in a closed container, Methoxy Polyethylene Glycol 1000 can be kept for at least two years.







Regulatory process names
Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy-


IUPAC names
2-methoxyethanol

Agent I3C8

Dodecaethylene glycol monomethyl ether

METHOXY POLYETHYLENE GLYCOL 1000

Methoxy Polyethylene Glycol 1000

Polietilenglicolmonometileter

Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-hydroxy-

Poly(oxy-1,2-ethanediyl), a-methyl-w-hydroxy-

POLY(OXY-1,2-ETHANEDIYL), α-METHYL-ω-HYDROXY-

Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy-

POLYETHYLENE GLYCOL MONOMETHYL ETHER

polyethylene glycol monomethyl ether

Polyethylene glycol monomethyl ether; Carbowax Sentry Methoxypolyethylene glycol

Polyethylenglykolmonomethylether



Trade names
Dodecaethylene glycol monomethyl ether

Other names
Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy

polyethylene(4-6)glycolmonomethylether


This information is based on Ataman's present knowledge and is intended to provide general notes on our products and their uses.
It should not, therefore, be construed as guaranteeing specific properties of the products described or their suitability for a particular application.
Any existing industrial property rights must be observed.
The quality of our products is guaranteed under our General Conditions of Sale.
Please check our website: www.atamankimya.com