α-Tocopheryl acetate (alpha-tocopherol acetate) is a specific form of vitamin E that’s often found in skin care products and dietary supplements.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a natural form of vitamin E and it is stable in terms of shelf life.
CAS Number: 58-95-7 RRR-α-isomer
EC Number: 200-405-4
MDL Number: MFCD00072052
Chemical formula: C31H52O3
α-Tocopheryl acetate (alpha-tocopherol acetate) is a natural form of vitamin E and it is stable in terms of shelf life.
α-Tocopheryl acetate (alpha-tocopherol acetate) is probably the best form for people actively trying to prevent heart disease.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used in the dietary and clinical supplementations.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a off-white crystalline solid
α-Tocopheryl acetate (alpha-tocopherol acetate) is the most bioactive of the naturally occurring forms of Vitamin E.
Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a tocol.
α-Tocopheryl acetate (alpha-tocopherol acetate) is odorless off-white crystals.
α-Tocopheryl acetate (alpha-tocopherol acetate) darkens at 401° F.
α-Tocopheryl acetate (alpha-tocopherol acetate), also known as vitamin E acetate, is a synthetic form of vitamin E.
α-Tocopheryl acetate (alpha-tocopherol acetate) is an ester of acetic acid and α-tocopherol.
α-Tocopheryl acetate (alpha-tocopherol acetate) has many proposed uses, primarily because of its antioxidant properties, which are thought to protect cells from free radicals.
α-Tocopheryl acetate (alpha-tocopherol acetate), also known as vitamin E acetate, is a common vitamin supplement with the molecular formula C31H52O3 (for 'α' form).
α-Tocopheryl acetate (alpha-tocopherol acetate) is the ester of acetic acid and tocopherol (vitamin E).
While there are many studies on the potential benefits of AT, studies on the benefits of α-Tocopheryl acetate (alpha-tocopherol acetate) are limited.
The results of these studies on α-Tocopheryl acetate (alpha-tocopherol acetate) are mixed.
α-Tocopheryl acetate (alpha-tocopherol acetate) usually needs to be used with other vitamins and minerals to have a beneficial effect.
α-Tocopheryl acetate (alpha-tocopherol acetate) belongs to the class of organic compounds known as vitamin e compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
α-Tocopheryl acetate (alpha-tocopherol acetate), also known as a-tocopherol acetic acid, belongs to the class of organic compounds known as vitamin E compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
α-Tocopheryl acetate (alpha-tocopherol acetate) is based on a literature review a significant number of articles have been published on alpha-Tocopherol acetate.
α-Tocopheryl acetate (alpha-tocopherol acetate), also known simply as tocopheryl acetate, is a synthetic form of vitamin E found in dietary supplements and skin care products.
α-Tocopheryl acetate (alpha-tocopherol acetate) appears as odorless off-white crystals.
α-Tocopheryl acetate (alpha-tocopherol acetate) darkens at 401 °F.
α-Tocopheryl acetate (alpha-tocopherol acetate) acetate is a tocol.
α-Tocopheryl acetate (alpha-tocopherol acetate) is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements.
In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the alpha-tocopherol stereoisomers.
Moreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of α-Tocopheryl acetate (alpha-tocopherol acetate) that is most commonly used as a food additive when needed.
Alpha-tocopherol acetate is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in α-Tocopheryl acetate (alpha-tocopherol acetate).
Most individuals obtain adequate α-Tocopheryl acetate (alpha-tocopherol acetate) intake from their diets; genuine vitamin E deficiency is considered to be rare.
Nevertheless, α-Tocopheryl acetate (alpha-tocopherol acetate) is known to be a fat-soluble antioxidant that has the capability to neutralize endogenous free radicals.
This biologic action of α-Tocopheryl acetate (alpha-tocopherol acetate) consequently continues to generate ongoing interest and study in whether or not its antioxidant abilities may be used to help assist in preventing or treating a number of different conditions like cardiovascular disease, ocular conditions, diabetes, cancer and more.
At the moment however, there exists a lack of formal data and evidence to support any such additional indications for α-Tocopheryl acetate (alpha-tocopherol acetate) use.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a natural product found in Senegalia catechu, Myriactis humilis, and Senegalia polyacantha with data available.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a natural tocopherol and one of the most potent antioxidant tocopherols.
α-Tocopheryl acetate (alpha-tocopherol acetate) exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus.
α-Tocopheryl acetate (alpha-tocopherol acetate) has four methyl groups on the 6-chromanol nucleus.
The natural d form of α-Tocopheryl acetate (alpha-tocopherol acetate) is more active than its synthetic dl-alpha-tocopherol racemic mixture.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a specific form of vitamin E that’s often found in skin care products and dietary supplements.
α-Tocopheryl acetate (alpha-tocopherol acetate)’s also known as tocopheryl acetate, tocopherol acetate, or vitamin E acetate.
α-Tocopheryl acetate (alpha-tocopherol acetate) is known for its antioxidant properties.
Antioxidants help to protect your body from damaging compounds called free radicals.
Normally, free radicals form when your body converts food into energy.
However, free radicals can also come from UV light, cigarette smoke, and air pollution.
In nature, α-Tocopheryl acetate (alpha-tocopherol acetate) comes in the form of tocopheryl or tocotrienol.
Both tocopheryl and tocotrienol have four forms, known as alpha, beta, gamma, and delta.
α-Tocopheryl acetate (alpha-tocopherol acetate) is the most active form of vitamin E in humans.
α-Tocopheryl acetate (alpha-tocopherol acetate) is more stable than AT, meaning it can better withstand environmental stresses such as heat, air, and light.
This makes α-Tocopheryl acetate (alpha-tocopherol acetate) ideal for use in supplements and fortified foods because it has a longer shelf life.
Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements.
In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the alpha-tocopherol stereoisomers.
α-Tocopheryl acetate (alpha-tocopherol acetate), also known as vitamin E acetate, is a synthetic form of vitamin E.
α-Tocopheryl acetate (alpha-tocopherol acetate) is the ester of acetic acid and α-tocopherol.
USES and APPLICATIONS of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
α-Tocopheryl acetate (alpha-tocopherol acetate) is used in prevention and treatment of vitamin E deficiencies.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used as a component of growth medium for retinal cell lines.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used as an external standard in high performance liquid chromatography (HPLC) to study its composition in leafy vegetables.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used in the preparation of trans-resveratrol-encapsulated lipid nanocarriers (R-nano).
α-Tocopheryl acetate (alpha-tocopherol acetate) is often used in dermatological products such as skin creams.
α-Tocopheryl acetate (alpha-tocopherol acetate) is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol.
Claims are made for beneficial antioxidant effects.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used as an alternative to tocopherol itself because the phenolic hydroxyl group is blocked, providing a less acidic product with a longer shelf life.
α-Tocopheryl acetate (alpha-tocopherol acetate) is believed that the acetate slowly hydrolyzed after it is absorbed into the skin, regenerating tocopherol and providing protection against the sun's ultraviolet rays.
Although there is widespread use of α-Tocopheryl acetate (alpha-tocopherol acetate) as a topical medication, with claims for improved wound healing and reduced scar tissue, reviews have repeatedly concluded that there is insufficient evidence to support these claims.
There are reports of vitamin E-induced allergic contact dermatitis from the use of vitamin-E derivatives such as tocopheryl linoleate and α-Tocopheryl acetate (alpha-tocopherol acetate) in skin care products.
Incidence is low despite widespread use.
Cosmetic Uses of α-Tocopheryl acetate (alpha-tocopherol acetate): antioxidants and skin conditioning.
α-Tocopheryl acetate (alpha-tocopherol acetate) is considered the most stable and active form of vitamin E and the best option overall for treating vitamin E deficiency.
α-Tocopheryl acetate (alpha-tocopherol acetate) is marketed to prevent several health conditions or diseases.
α-Tocopheryl acetate (alpha-tocopherol acetate) itself is naturally found in various foods, added to others, or used in commercially available products as a dietary supplement.
Moreover, α-Tocopheryl acetate (alpha-tocopherol acetate) is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed 6.
α-Tocopheryl acetate (alpha-tocopherol acetate) is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in vitamin E.
This biologic action of α-Tocopheryl acetate (alpha-tocopherol acetate) consequently continues to generate ongoing interest and study in whether or not its antioxidant abilities may be used to help assist in preventing or treating a number of different conditions like cardiovascular disease, ocular conditions, diabetes, cancer and more.
At the moment however, there exists a lack of formal data and evidence to support any such additional indications for α-Tocopheryl acetate (alpha-tocopherol acetate) use.
α-Tocopheryl acetate (alpha-tocopherol acetate), known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects.
Nevertheless, α-Tocopheryl acetate (alpha-tocopherol acetate) is known to be a fat-soluble antioxidant that has the capability to neutralize endogenous free radicals.
α-Tocopheryl acetate (alpha-tocopherol acetate) may be of limited benefit in some with asthma and rheumatoid arthritis.
α-Tocopheryl acetate (alpha-tocopherol acetate) may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome.
α-Tocopheryl acetate (alpha-tocopherol acetate) may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported.
α-Tocopheryl acetate (alpha-tocopherol acetate) may help relieve some muscle cramps.
α-Tocopheryl acetate (alpha-tocopherol acetate) is often used in dermatological products such as skin creams.
α-Tocopheryl acetate (alpha-tocopherol acetate) is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol.
Claims are made for beneficial antioxidant effects.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used as an alternative to tocopherol itself because the phenolic hydroxyl group is blocked, providing a less acidic product with a longer shelf life.
It is believed that α-Tocopheryl acetate (alpha-tocopherol acetate) is slowly hydrolyzed after it is absorbed into the skin, regenerating tocopherol and providing protection against the sun's ultraviolet rays.
α-Tocopheryl acetate (alpha-tocopherol acetate) was first synthesized in 1963 by workers at Hoffmann-La Roche.
Although there is widespread use of α-Tocopheryl acetate (alpha-tocopherol acetate) as a topical medication, with claims for improved wound healing and reduced scar tissue, reviews have repeatedly concluded that there is insufficient evidence to support these claims.
There are reports of vitamin E-induced allergic contact dermatitis from use of α-Tocopheryl acetate (alpha-tocopherol acetate) derivatives such as tocopheryl linoleate and tocopherol acetate in skin care products.
Incidence of α-Tocopheryl acetate (alpha-tocopherol acetate) is low despite widespread use.
USE OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE) IN COSMETICS
α-Tocopheryl acetate (alpha-tocopherol acetate) is commonly used in dermatological products such as skin creams.
α-Tocopheryl acetate (alpha-tocopherol acetate) is not oxidized and penetrates through the skin into living cells where about 5% is converted to free tocopherol.
Beneficial antioxidant effects are claimed.
α-Tocopheryl acetate (alpha-tocopherol acetate) is used as an alternative to tocopherol itself as the phenolic hydroxyl group is blocked resulting in a product with lower acidity and longer shelf life.
Acetate hydrolyzes slowly after being absorbed into the skin, and is thought to regenerate tocopherols and protect them from the sun's UV rays.
α-Tocopheryl acetate (alpha-tocopherol acetate) was first synthesized in 1963 by an employee of Hoffmann-La Roche.
α-Tocopheryl acetate (alpha-tocopherol acetate) is widely used as a topical agent, claiming improved wound healing and reduced scar tissue, but reviews have repeatedly concluded that there is insufficient evidence to support this.
Vitamin E-induced allergic contact dermatitis has been reported when vitamin E derivatives such as tocopheryl linoleate and α-Tocopheryl acetate (alpha-tocopherol acetate) are used in skin care products.
Despite α-Tocopheryl acetate (alpha-tocopherol acetate)'s widespread use, its incidence is low.
PHARMACODYNAMICS, α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
α-Tocopheryl acetate (alpha-tocopherol acetate) has antioxidant activity.
α-Tocopheryl acetate (alpha-tocopherol acetate) may also have anti-atherogenic, antithrombotic, anticoagulant, neuroprotective, antiviral, immunomodulatory, cell membrane-stabilizing and antiproliferative actions.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a collective term used to describe eight separate forms, the best-known form being alpha-tocopherol.
α-Tocopheryl acetate (alpha-tocopherol acetate) is a fat-soluble vitamin and is an important antioxidant.
α-Tocopheryl acetate (alpha-tocopherol acetate) acts to protect cells against the effects of free radicals, which are potentially damaging by-products of the body's metabolism.
α-Tocopheryl acetate (alpha-tocopherol acetate) is often used in skin creams and lotions because it is believed to play a role in encouraging skin healing and reducing scarring after injuries such as burns.
There are three specific situations when a α-Tocopheryl acetate (alpha-tocopherol acetate) deficiency is likely to occur.
α-Tocopheryl acetate (alpha-tocopherol acetate) is seen in persons who cannot absorb dietary fat, has been found in premature, very low birth weight infants (birth weights less than 1500 grams, or 3½ pounds), and is seen in individuals with rare disorders of fat metabolism.
α-Tocopheryl acetate (alpha-tocopherol acetate) deficiency is usually characterized by neurological problems due to poor nerve conduction.
Symptoms may include infertility, neuromuscular impairment, menstrual problems, miscarriage and uterine degradation.
Preliminary research has led to a widely held belief that α-Tocopheryl acetate (alpha-tocopherol acetate) may help prevent or delay coronary heart disease.
Antioxidants such as α-Tocopheryl acetate (alpha-tocopherol acetate) help protect against the damaging effects of free radicals, which may contribute to the development of chronic diseases such as cancer.
α-Tocopheryl acetate (alpha-tocopherol acetate) also protects other fat-soluble vitamins (A and B group vitamins) from destruction by oxygen.
Low levels of α-Tocopheryl acetate (alpha-tocopherol acetate) have been linked to increased incidence of breast and colon cancer.
CHEMISTRY OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
α-Tocopheryl acetate (alpha-tocopherol acetate) is a fat-soluble liquid at room temperature.
α-Tocopheryl acetate (alpha-tocopherol acetate) has 3 chiral centers and thus 8 stereoisomers.
α-Tocopheryl acetate (alpha-tocopherol acetate) is made by esterifying α-tocopherol with acetic acid.
α-Tocopheryl acetate (alpha-tocopherol acetate) is the most common isomer used for various purposes.
This is because α-tocopherol exists primarily as RRR-α-tocopherol in nature.
Alpha-tocopheryl acetate does not boil at atmospheric pressure and begins to decompose at 240°C.
Vacuum distillation of α-Tocopheryl acetate (alpha-tocopherol acetate) is possible.
Boiling of α-Tocopheryl acetate (alpha-tocopherol acetate) is at 184 °C, 0.01 mmHg, 194 °C (0.025 mmHg), and 224 °C (0.3 mmHg).
In fact, α-Tocopheryl acetate (alpha-tocopherol acetate) is not particularly degraded by air, visible light, or ultraviolet light.
The refractive index of α-Tocopheryl acetate (alpha-tocopherol acetate) at 20 °C is between 1.4950 and 1.4972.
α-Tocopheryl acetate (alpha-tocopherol acetate) is hydrolyzed to alpha-tocopherol and acetic acid under appropriate conditions or when ingested by humans.
α-Tocopheryl acetate (alpha-tocopherol acetate) exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus.
α-Tocopheryl acetate (alpha-tocopherol acetate) has four methyl groups on the 6-chromanol nucleus.
The natural d form of α-Tocopheryl acetate (alpha-tocopherol acetate)l is more active than its synthetic dl-alpha-tocopherol racemic mixture.
ALTERNATIVE PARENTS OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
*Diterpenoids
*1-benzopyrans
*Alkyl aryl ethers
*Benzenoids
*Carboxylic acid esters
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds
SUBSTITUENTS OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
*Diterpenoid
*Chromane
*Benzopyran
*1-benzopyran
*Alkyl aryl ether
*Benzenoid
*Carboxylic acid ester
*Carboxylic acid derivative
*Oxacycle
*Organoheterocyclic compound
*Ether
*Monocarboxylic acid or derivatives
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Carbonyl group
*Organooxygen compound
*Aromatic heteropolycyclic compound
AIR AND WATER REACTIONS OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
α-Tocopheryl acetate (alpha-tocopherol acetate) may be sensitive to prolonged exposure to light and air.
α-Tocopheryl acetate (alpha-tocopherol acetate) is insoluble in water.
REACTIVITY PROFILE OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
α-Tocopheryl acetate (alpha-tocopherol acetate) is an ester.
Esters react with acids to liberate heat along with alcohols and acids.
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions.
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
POTENTIAL BENEFITS OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
Using AT on the skin, especially with vitamin C, helps to prevent UV damage to the skin.
In a review of studies, the Linus Pauling Institute at Oregon State University found that using AT with vitamin C on the skin decreased sunburned cells, DNA damage, and skin pigmentation following UV exposure.
However, AT is less stable in the environment than α-Tocopheryl acetate (alpha-tocopherol acetate), which makes it harder to store.
While α-Tocopheryl acetate (alpha-tocopherol acetate) is less sensitive to heat and light than AT is, there’s less conversion of α-Tocopheryl acetate (alpha-tocopherol acetate) to the active AT form within the skin.
This is because the cells in the upper layer of your skin are much less metabolically active.
As a result, using cosmetic products containing α-Tocopheryl acetate (alpha-tocopherol acetate) on your skin may not be very effective.
This is supported by a study from 2011 published in the Medical Principles and Practice journal.
Using several commercial skin care products, researchers looked at the conversion of α-Tocopheryl acetate (alpha-tocopherol acetate) to the active AT form in the skin of live rats.
They found that, while there was α-Tocopheryl acetate (alpha-tocopherol acetate) in the upper levels of the skin after using the product, there was no active AT.
CHEMISTRY OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
At room temperature, α-Tocopheryl acetate (alpha-tocopherol acetate) is a fat-soluble liquid.
α-Tocopheryl acetate (alpha-tocopherol acetate) has 3 chiral centers and thus 8 stereoisomers.
α-Tocopheryl acetate (alpha-tocopherol acetate) is made by esterifying α-tocopherol with acetic acid.
2R,4R,8R-isomer, also known as α-Tocopheryl acetate (alpha-tocopherol acetate), is the most common isomer used for various purposes.
This is because α-Tocopheryl acetate (alpha-tocopherol acetate) occurs in nature primarily as RRR-α-tocopherol.
α-Tocopherol acetate does not boil at atmospheric pressure and begins to degrade at 240 °C.
α-Tocopheryl acetate (alpha-tocopherol acetate) can be vacuum distilled: it boils at 184 °C at 0.01 mmHg, at 194 °C (0.025 mmHg) and at 224 °C (0.3 mmHg).
In practice, α-Tocopheryl acetate (alpha-tocopherol acetate) is not degraded notably by air, visible light or UV-radiation.
α-Tocopheryl acetate (alpha-tocopherol acetate) has a refractive index of 1.4950–1.4972 at 20 °C.
α-Tocopheryl acetate (alpha-tocopherol acetate) is hydrolyzed to α-tocopherol and acetic acid under suitable conditions or when ingested by people.
WHERE CAN I FIND α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE)?
Cosmetics and supplements:
You’ll find α-Tocopheryl acetate (alpha-tocopherol acetate) in a variety of skin care products.
The antioxidant properties of α-Tocopheryl acetate (alpha-tocopherol acetate) can help to prevent damage to skin caused by free radicals from UV exposure.
α-Tocopheryl acetate (alpha-tocopherol acetate) may also have an anti-inflammatory effect on the skin.
Due to its higher stability, α-Tocopheryl acetate (alpha-tocopherol acetate) is also used in vitamin E dietary supplements.
When taken orally, α-Tocopheryl acetate (alpha-tocopherol acetate) is converted to AT within the intestine.
α-Tocopheryl acetate (alpha-tocopherol acetate) is in most multi-vitamins, so be sure to check how much is in your multi-vitamin if you take one, before adding a supplement.
FOODS, α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
In addition to dietary supplements and cosmetic products, you can find vitamin E in the following foods:
*green leafy vegetables, such as broccoli and spinach
*oils, such as sunflower oil, wheat germ oil, and corn oil
*sunflower seeds
*nuts, such as almonds and peanuts
*whole grains
*fruits, such as kiwi and mango
α-Tocopheryl acetate (alpha-tocopherol acetate) is also added to fortified foods, such as cereals, fruit juices, and many spreads.
You can check food labels to see if α-Tocopheryl acetate (alpha-tocopherol acetate) has been added.
If you want to increase your α-Tocopheryl acetate (alpha-tocopherol acetate) intake, you should start by first increasing your intake of these foods.
MECHANISM OF ACTION OF α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
Although all forms of α-Tocopheryl acetate (alpha-tocopherol acetate) exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biological activity.
α-Tocopheryl acetate (alpha-tocopherol acetate)'s anti-atherogenic activity involves the inhibition of the oxidation of LDL and the accumulation of oxLDL in the arterial wall.
α-Tocopheryl acetate (alpha-tocopherol acetate) also appears to reduce oxLDL-induced apoptosis in human endothelial cells.
Oxidation of LDL is a key early step in atherogenesis as it triggers a number of events which lead to the formation of atherosclerotic plaque.
In addition, α-Tocopheryl acetate (alpha-tocopherol acetate) inhibits protein kinase C (PKC) activity.
PKC plays a role in smooth muscle cell proliferation, and, thus, the inhibition of PKC results in inhibition of smooth muscle cell proliferation, which is involved in atherogenesis.
α-Tocopheryl acetate (alpha-tocopherol acetate)'s antithrombotic and anticoagulant activities involves the downregulation of the expression of intracellular cell adhesion molecule(ICAM)-1 and vascular cell adhesion molecule(VCAM)-1 which lowers the adhesion of blood components to the endothelium.
In addition, α-Tocopheryl acetate (alpha-tocopherol acetate) upregulates the expression of cytosolic phospholipase A2 and cyclooxygenase (COX)-1 which in turn enhances the release of prostacyclin.
Prostacyclin is a vasodilating factor and inhibitor of platelet aggregation and platelet release.
α-Tocopheryl acetate (alpha-tocopherol acetate) is also known that platelet aggregation is mediated by a mechanism involving the binding of fibrinogen to the glycoprotein IIb/IIIa (GPIIb/IIIa) complex of platelets.
GPIIb/IIIa is the major membrane receptor protein that is key to the role of the platelet aggregation response.
GPIIb is the alpha-subunit of this platelet membrane protein.
Alpha-tocopherol downregulates GPIIb promoter activity which results in reduction of GPIIb protein expression and decreased platelet aggregation.
α-Tocopheryl acetate (alpha-tocopherol acetate) has also been found in culture to decrease plasma production of thrombin, a protein which binds to platelets and induces aggregation.
A metabolite of α-Tocopheryl acetate (alpha-tocopherol acetate) called vitamin E quinone or alpha-tocopheryl quinone (TQ) is a potent anticoagulant.
This metabolite inhibits vitamin K-dependent carboxylase, which is a major enzyme in the coagulation cascade.
The neuroprotective effects of α-Tocopheryl acetate (alpha-tocopherol acetate) are explained by its antioxidant effects.
Many disorders of the nervous system are caused by oxidative stress.
α-Tocopheryl acetate (alpha-tocopherol acetate) protects against this stress, thereby protecting the nervouse system.
The immunomodulatory effects of α-Tocopheryl acetate (alpha-tocopherol acetate) have been demonstrated in vitro, where alpha-tocopherol increases mitogenic response of T lymphocytes from aged mice.
The mechanism of this response by α-Tocopheryl acetate (alpha-tocopherol acetate) is not well understood, however it has been suggested that vitamin E itself may have mitogenic activity independent of its antioxidant activity.
Lastly, the mechanism of action of α-Tocopheryl acetate (alpha-tocopherol acetate)'s antiviral effects (primarily against HIV-1) involves its antioxidant activity.
α-Tocopheryl acetate (alpha-tocopherol acetate) reduces oxidative stress, which is thought to contribute to HIV-1 pathogenesis, as well as to the pathogenesis of other viral infections.
α-Tocopheryl acetate (alpha-tocopherol acetate) also affects membrane integrity and fluidity and, since HIV-1 is a membraned virus, altering membrane fluidity of HIV-1 may interfere with its ability to bind to cell-receptor sites, thus decreasing its infectivity.
PHYSICAL and CHEMICAL PROPERTIES of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
Chemical formula: C31H52O3
Molar mass: 472.743 g/mol
Appearance: pale yellow, viscous liquid
Melting point: –27.5 °C
Boiling point: 240 °C decays without boiling
Solubility in water: insoluble
Solubility: soluble in acetone, chloroform, diethyl ether; poorly soluble in ethanol
Molecular Weight: 472.7 g/mol
XLogP3-AA: 10.8
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 14
Exact Mass: 472.39164552 g/mol
Monoisotopic Mass: 472.39164552 g/mol
Topological Polar Surface Area: 35.5Ų
Heavy Atom Count: 34
Formal Charge: 0
Complexity: 602
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Formula : C31H52O3
Molecular weight : 472,74 g/mol
CAS-No. : 58-95-7
EC-No. : 200-405-4
Physical state: liquid
Color: No data available
Odor: No data available
Melting point/freezing point:
Melting point: -28 °C
Initial boiling point and boiling range: 300 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 2,94 mPa.s at 25 °C
Water solubility insoluble
Partition coefficient: n-octanol/water:
log Pow: 12,26 at 25 °C
Vapor pressure: No data available
Density: 0,94 - 0,95 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Water Solubility: 2.9e-06 g/L
logP: 9.19
logP: 10.42
logS: -8.2
pKa (Strongest Basic): -4.9
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 0
Polar Surface Area: 35.53 Ų
Rotatable Bond Count: 14
Refractivity: 144.53 m³·mol⁻¹
Polarizability: 60.23 ų
Number of Rings: 2
Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Chemical Formula: C31H52O3
IUPAC name: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
InChI Identifier: InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
InChI Key:ZAKOWWREFLAJOT-UHFFFAOYSA-N
Isomeric SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(C)=O)=C(C)C(C)=C2O1
Average Molecular Weight: 472.7428
Monoisotopic Molecular Weight: 472.39164553
Molecular Weight: 472.7 g/mol
XLogP3-AA: 10.8
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 14
Exact Mass: 472.39164552 g/mol
Monoisotopic Mass: 472.39164552 g/mol
Topological Polar Surface Area: 35.5Ų
Heavy Atom Count: 34
Formal Charge: 0
Complexity: 602
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CBNumber:CB5241875
Molecular Formula:C31H52O3
Molecular Weight:472.74
MDL Number:MFCD00072052
MOL File:58-95-7.mol
Melting point: ~25 °C(lit.)
alpha: 3 º (c=2, in ethanol 25 ºC)
Boiling point: 224 °C0.3 mm Hg(lit.)
Density: 0.953 g/mL at 25 °C(lit.)
refractive index: n20/D 1.496(lit.)
Flash point: >230 °F
storage temp.: room temp
solubility: Practically insoluble in water, freely soluble in acetone,
in anhydrous ethanol and in fatty oils, soluble in ethanol (96 per cent).
form: oil or semi-solid
color: yellow
Odor: cryst., odorless
Water Solubility: Merck: 14,9495
Stability: Stable.
Incompatible with strong oxidizing agents.
LogP: 12.260 (est)
CAS DataBase Reference 58-95-7(CAS DataBase Reference)
FDA 21 CFR: 182.8892
Substances Added to Food (formerly EAFUS): ALPHA-TOCOPHEROL ACETATE
SCOGS (Select Committee on GRAS Substances): alpha-Tocopherol acetate
FDA UNII: A7E6112E4N
NIST Chemistry Reference: Vitamin e acetate(58-95-7)
EPA Substance Registry System: D-.alpha.-Tocopheryl acetate (58-95-7)
Molecular form: C31H52O3
Appearance: Light Yellow Think Oil to Off-White Low Melting Solid
Mol. Weight: 430.71
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: NA
FIRST AID MEASURES of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
*Storage stability:
Recommended storage temperature: 2 - 8 °C
STABILITY and REACTIVITY of α-TOCOPHERYL ACETATE (ALPHA-TOCOPHEROL ACETATE):
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
SYNONYMS:
(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate
α-Tocopherol acetate
Vitamin E acetate
Vitamin E acetate
alpha-Tocopherol acetate
58-95-7
Tocopherol acetate
Alfacol
D-alpha-tocopherol acetate
D-ALPHA-TOCOPHERYL ACETATE
Ecofrol
Contopheron
Tofaxin
Econ
Ephynal acetate
(+)-alpha-Tocopherol acetate
Tokoferol acetate
Evipherol
Tocopherex
Tocophrin
Erevit
Vitamin E acetate
alpha-Tocopherol acetate
58-95-7
Tocopherol acetate
Alfacol
Tocopheryl acetate
D-alpha-tocopherol acetate
D-ALPHA-TOCOPHERYL ACETATE
Ecofrol
Contopheron
Tofaxin
Econ
Ephynal acetate
Tokoferol acetate
Evipherol
Fertilvit
Tocopherex
Tocophrin
Erevit
Gevex
Tocopheryl acetate
Combinal E
Epsilan-M
E-Toplex
E-Ferol
Endo E Dompe
Spondyvit
alpha-Tocopheryl acetate
Copherol 1250
Covitol 1100
Covitol 1360
Vitamin Ealpha acetate
Vitamin E acetate, d-
Nanotopes
Gevex
(+)-alpha-Tocopherol acetate
Combinal E
Epsilan-M
E-Toplex
E-Ferol
Endo E Dompe
Ephynal
Spondyvit
Juvela
alpha-Tocopheryl acetate
Copherol 1250
Covitol 1100
Covitol 1360
Vitamin Ealpha acetate
Vitamin E acetate, d-
Nanotopes
Simmyungsaengmosu
NatAc
Tinoderm E
Natur-E granulate
DL-alpha-Tocopheryl acetate
Lutavit E 50
(+)-alpha-Tocopheryl acetate
CCRIS 4389
(R,R,R)-alpha-Tocopheryl acetate
C31H52O3
EINECS 200-405-4
UNII-A7E6112E4N
(+-)-alpha-Tocopherol acetate
52225-20-4
D-alpha tocoferil acetate
alpha-Tocopherol acetate, all rac
(2R,4'R,8'R)-alpha-Tocopheryl acetate
A7E6112E4N
DL-alpha-Tocopherylacetate
d-Alpha Tocopheryl Acetate
.alpha.-Tocopherol acetate
alpha-Tocopherol acetate, (2R,4'R,8'R)-
EINECS 231-710-0
MFCD00072052
RRR-alpha-tocopheryl acetate
(+)-alfa-tocopherol acetate
alpha-tocopheryl acetate, D-
D-.alpha.-Tocopherol acetate
Tocopheryl acetate, D-alpha-
Vitamin E Acetate (D-form)
UNII-9E8X80D2L0
Vectan (TN)
BRN 0097512
CCRIS 6054
54-22-8
Simmyungsaengmosu
NatAc
Tinoderm E
Fertilvit
Natur-E granulate
DL-alpha-Tocopheryl acetate
Lutavit E 50
Ephynal
Juvela
(+)-alpha-Tocopheryl acetate
CCRIS 4389
(R,R,R)-alpha-Tocopheryl acetate
EINECS 200-405-4
UNII-A7E6112E4N
52225-20-4
D-alpha tocoferil acetate
(2R,4'R,8'R)-alpha-Tocopheryl acetate
A7E6112E4N
DL-alpha-Tocopherylacetate
d-Alpha Tocopheryl Acetate
alpha-Tocopherol acetate, (2R,4'R,8'R)-
RRR-alpha-tocopheryl acetate
(+)-alfa-tocopherol acetate
alpha-tocopheryl acetate, D-
54-22-8
DTXSID1031096
CHEBI:32321
9E8X80D2L0
D-|A-Tocopherol acetate
Tocopherolacetate, alpha-
DL-alpha tocopheryl acetate
EINECS 257-757-7
MFCD00072042
T-3376
d-Vitamin E acetate
Tocopherol acetate [JAN]
.alpha.-Tocopheryl acetate
Tocopherol acetate (JP17)
Tocopheryl Acetate, d-Alpha
CHEMBL1047
NCGC00166253-02
SCHEMBL22298
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
MLS001335985
MLS001335986
DTXCID601356
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*)))-
DTXSID3021356
(+)-.alpha.-Tocopherol acetate
(+)-.alpha.-Tocopheryl acetate
DL-alpha-Tocopherylacetate (Vitamin E acetate)
EC 231-710-0
Syntopherol acetate
HMS2230C20
5-17-04-00169 (Beilstein Handbook Reference)
Tox21_111491
Tox21_111564
Tox21_113467
Tox21_303444
ALPHA-TOCOPHEROL ACETATE, D-
ALPHA-TOCOPHEROL ACETATE. D-
LS-245
Rovimix E 50SD
(R,R,R)-.alpha.-Tocopheryl acetate
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
AKOS025117621
NSC 755840
NSC-755840
Tox21_113467_1
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate
1406-70-8
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-
.ALPHA.-TOCOPHEROL ACETATE, D-
CAS-58-95-7
NCGC00095255-08
NCGC00166253-01
NCGC00257504-01
DL--Tocopherol acetate
AS-13784
J24.807J
LS-39402
LS-53371
DTXSID1031096
CHEBI:32321
9E8X80D2L0
D-|A-Tocopherol acetate
T-3376
d-Vitamin E acetate
Tocopheryl Acetate, d-Alpha
NCGC00166253-02
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
DTXCID601356
alpha-Tocopherol acetate, all rac
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*)))-
DTXSID3021356
DL-alpha-Tocopherylacetate (Vitamin E acetate)
D-.alpha.-Tocopherol acetate
ALPHA-TOCOPHEROL ACETATE, D-
ALPHA-TOCOPHEROL ACETATE. D-
Vectan (TN)
NSC 755840
NSC-755840
SMR000857327
CAS-52225-20-4
O-Acetyl-alpha-tocopherol
(2R,4'R,8'R)-.alpha.-Tocopheryl acetate
DL-alpha-Tocopherol acetate, >=96% (HPLC)
Vitamin E acetate dl-form
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
C13202
D01735
DL-alpha-Tocopherol acetate, analytical standard
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] acetate
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-b- enzopyran-6-ol, acetate
d,l-alpha-Tocopheryl acetate
Eusovit
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, 6-acetate, (2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-rel-
D-.alpha.-Tocopheryl acetate
Alpha-tocopherol acetate, dl-
Q-201933
vitamin E acetate, (2R-(2R*(4R*,8R*)))-isomer
W-109259
ECA8C22F-B5D3-4B88-A9B7-AF6C600001BB
vitamin E acetate, ((2R*(4R*,8R*))-(+-))-isomer
DL-alpha-Tocopherol acetate, tested according to Ph.Eur.
DTXCID60196594
OptoVit E
SynAC
Rovimix E 50
Alpha Tocopheryl Acetate, United States Pharmacopeia (USP) Reference Standard
alpha-Tocopherol acetate, European Pharmacopoeia (EP) Reference Standard
DL-alpha-Tocopherol acetate, certified reference material, TraceCERT(R)
DL-alpha-Tocopherylacetate (Vitamin E acetate) 10 microg/mL in Acetonitrile
(+)-alpha-Tocopherol acetate, BioReagent, suitable for insect cell culture, ~1360 IU/g
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate #
Tocopheryl Acetate, a, Pharmaceutical Secondary Standard; Certified Reference Material
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate
(2R*(4R*,8R*))-(1)-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
[2R-[2R*(4R,8R*)]]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate
2H-1-benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate,
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2R*(4R*,8R*)))-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate,(2R*(4R*,8R*))-(+-)-
All-rac-alpha-tocopheryl acetate for peak identification, European Pharmacopoeia (EP) Reference Standard
Tocopheryl acetate,alpha
Alpha Tocopheryl Acetate
D-ALPHA TOCOFERIL ACETATE (MART.)
D-ALPHA TOCOFERIL ACETATE [MART.]
UNII-WR1WPI7EW8
Copherol 12250
d-|ATocopheryl Acetate
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-
DL--Tocopherol acetate
J24.807J
SMR000857327
CAS-52225-20-4
MFCD00072042
.alpha.-Tocopheryl acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, 6-acetate, (2R)-
D-.alpha.-Tocopheryl acetate
(+)-.alpha.-Tocopherol acetate
(+)-.alpha.-Tocopheryl acetate
DTXCID60196594
(R,R,R)-.alpha.-Tocopheryl acetate
DL-alpha-Tocopherylacetate (Vitamin E acetate) 10 microg/mL in Acetonitrile
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate
EINECS 231-710-0
MFCD00072052
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2R*(4R*,8R*)))-
Tocopheryl acetate,alpha
Vitamin E Acetate (D-form)
Tocopheryl acetate, D-alpha-
Alpha Tocopheryl Acetate
D-ALPHA TOCOFERIL ACETATE (MART.)
D-ALPHA TOCOFERIL ACETATE [MART.]
UNII-9E8X80D2L0
BRN 0097512
O-Acetyl-|A-tocopherol
alpha-Tocopherylis acetas
AC1L3BMH
DL-|A-Tocopheryl acetate
.alpha.-tocopherol acetate, dl-
AC1Q1PB2
(+)-|A-Tocopherol acetate
(+)-|A-Tocopheryl Acetate
all-rac-|A-Tocopheryl acetate
DL-ALPHA-TOCOPHEROLACETATE
C31-H52-O3
(R,R,R)-|A-Tocopheryl Acetate
(2R,4'R,8'R)-alpha-Tocopherol acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-rel-
Tocopherol, acetate
Acetate, Tocopherol
ZINC4172337
alpha-tocopherylacetat
FT-0624407
a- tocopheryl acetate
D--Tocopherol acetate
(2R,4'R,8'R)-|A-Tocopherol Acetate
(2R,4'R,8'R)-|A-Tocopheryl Acetate
SC-16401
SC-18242
alpha Tocopherol Acetate
DSSTox_CID_1356
d alpha Tocopheryl Acetate
DL-alpha-Tocopherol acetate, 50% powder form
J10308
DL-alpha-Tocopherol acetate, EP/USP/FCC grade
DSSTox_RID_76104
DSSTox_RID_78863
DSSTox_GSID_21356
DSSTox_GSID_31096
Vitamin E acetate (unlabeled)
VITAMIN E ALPHA ACETATE
(+)- alpha -Tocopherol acetate
TOCOPHERYL ACETATE,D-ALPHA
D-alpha-Tocopheryl acetate, 97%
MolPort-003-928-528
DL-alpha-Tocopheryl acetate, 98%
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl- 2-(4,8,12-trimethyltridecyl)-, acetate
3, 4- dihydro- 2, 5, 7, 8- tetramethyl- 2- (4, 8, 12- trimethyltridecyl)- 2H- benzopyran- 6- yl acetate
HY-B1278
TOCOPHERYL ACETATE [WHO-DD]
Vitamin E acetate, unspecified form
TOCOPHERYL ACETATE, alpha, D-
s3681
Vitamin E (alpha tocopherol acetate)
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate
CCG-269474
CS-O-00415
DB14002
.ALPHA.-TOCOPHEROL ACETATE. D-
(+-)-alpha-Tocopherol Acetateacid ester
.ALPHA.-TOCOPHEROL ACETATE [MI]
TOCOPHERYL ACETATE, .ALPHA., D-
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol 6-Acetate
[2R*(4R*,8R*)]-()-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
133-80-2
2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,6-acetate, (2R)-
AK176402
all-rac-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
ALPHA TOCOPHERYL ACETATE (USP-RS)
RRR-ALPHA-TOCOPHERYL ACETATE [FCC]
TOCOPHERYL ACETATE,D-ALPHA [VANDF]
CS-0013056
T2322
VITAMIN E (ALPHA-TOCOPHERYL ACETATE)
A11606
D70796
alpha-TOCOPHEROL ACETATE, UNSPECIFIED FORM
EN300-7398027
A865381
Q364160
Z2681891483
(2R,4'R,8'R)-.alpha.-Tocopheryl acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-rel-
Tocopherolacetate, alpha-
Tocopherol acetate [JAN]
Tocopherol acetate (JP17)
CHEMBL1047
SCHEMBL22298
MLS001335985
MLS001335986
DL-ALPHA-TOCOPHEROLACETATE
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate #
EC 231-710-0
HMS2230C20
(2R,4'R,8'R)-alpha-Tocopherol acetate
[2R-[2R*(4R,8R*)]]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
5-17-04-00169 (Beilstein Handbook Reference)
Acetate, Tocopherol
Tox21_111491
Tox21_111564
Tox21_113467
Tox21_303444
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
AKOS025117621
Tox21_113467_1
D--Tocopherol acetate
.ALPHA.-TOCOPHEROL ACETATE, D-
CAS-58-95-7
NCGC00095255-08
NCGC00166253-01
NCGC00257504-01
AS-13784
alpha Tocopherol Acetate
d alpha Tocopheryl Acetate
DL-alpha-Tocopherol acetate, >=96% (HPLC)
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
D01735
DL-alpha-Tocopherol acetate, analytical standard
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] acetate
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-b- enzopyran-6-ol, acetate
Q-201933
Vitamin E acetate (unlabeled)
W-109259
VITAMIN E ALPHA ACETATE
ECA8C22F-B5D3-4B88-A9B7-AF6C600001BB
(+)- alpha -Tocopherol acetate
DL-alpha-Tocopherol acetate, tested according to Ph.Eur.
TOCOPHERYL ACETATE,D-ALPHA
HY-B1278
TOCOPHERYL ACETATE [WHO-DD]
Vitamin E acetate, unspecified form
TOCOPHERYL ACETATE, alpha, D-
s3681
Vitamin E (alpha tocopherol acetate)
Alpha Tocopheryl Acetate, United States Pharmacopeia (USP) Reference Standard
alpha-Tocopherol acetate, European Pharmacopoeia (EP) Reference Standard
DL-alpha-Tocopherol acetate, certified reference material, TraceCERT(R)
CCG-269474
DB14002
(+)-alpha-Tocopherol acetate, BioReagent, suitable for insect cell culture, ~1360 IU/g
.ALPHA.-TOCOPHEROL ACETATE. D-
Tocopheryl Acetate, a, Pharmaceutical Secondary Standard; Certified Reference Material
.ALPHA.-TOCOPHEROL ACETATE [MI]
TOCOPHERYL ACETATE, .ALPHA., D-
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate
All-rac-alpha-tocopheryl acetate for peak identification, European Pharmacopoeia (EP) Reference Standard
ALPHA TOCOPHERYL ACETATE (USP-RS)
RRR-ALPHA-TOCOPHERYL ACETATE [FCC]
TOCOPHERYL ACETATE,D-ALPHA [VANDF]
CS-0013056
T2322
VITAMIN E (ALPHA-TOCOPHERYL ACETATE)
A11606
D70796
alpha-TOCOPHEROL ACETATE, UNSPECIFIED FORM
EN300-7398027
A865381
Q364160
Z2681891483
Vitamin E acetate (dimethyl-13C2, acetyl-13C2, 99%; dimethyl-D6, 98%)
(+)-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL ACETATE
(2R-(2R*(4R*,8R*)))-3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRI-DECYL)-2H-1-BENZOPYRAN-6-OL ACETATE
2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,acetate, (2R)-
UNII-WR1WPI7EW8 component ZAKOWWREFLAJOT-CEFNRUSXSA-N
Vitamin E acetate (dimethyl-13C2, acetyl-13C2, 99%; dimethyl-D6, 98%)
(+)-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL ACETATE
(2R-(2R*(4R*,8R*)))-3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRI-DECYL)-2H-1-BENZOPYRAN-6-OL ACETATE
[2R*(4R*,8R*)]-(+-)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
12741-00-3
1407-18-7
26243-95-8
2H-1-Benzopiran-6-ol, 3,4-dihidro-2,5,7,8-tetrametil-2-[(4R,8R)-4,8,12-trimetiltridecil]-, 6-acetato, (2R)-rel-
2H-1-benzopirano-6-ol, 3,4-dihidro-2,5,7,8-tetrametil-2-[(4R, 8R)-4,8,12-trimetiltridecil]-, 6-acetato, ( 2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl- 2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R(4R,8R)]]-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R*(4R*,8R*)]-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R*(4R*,8R*)]-(.+.)-
2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,acetate, (2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-
Vitamin E acetate; 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
α-Tocopherol acetate
(+)-α-Tocopherol acetate
(+)-α-Tocopheryl acetate
D-α-tocopherol acetate
D-α-tocopheryl acetate
Alfacol
Combinal E
Contopheron
E-Ferol
E-Toplex
Ecofrol
Econ
Endo E Dompe
Ephynal acetate
Epsilan-M
Erevit
Evipherol
Fertilvit
Gevex
Juvela
Tocopherex
Tocophrin
Tofaxin
Tokoferol acetate
[2R-[2R*(4R,8R*)]]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
d-Vitamin E acetate
E-vicotrat
Spondyvit
(2R,4'R,8'R)-α-Tocopheryl acetate
(R,R,R)-α-Tocopheryl acetate
Copherol 1250
Covitol 1100
Covitol 1360
Tocopheryl acetate
Vitamin Ealpha acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
Vitamin E acetate
dl-α-Tocopheryl acetate
(+)-.alpha.-Tocopherol, O-acetyl-
(+)-α-Tocopherol acetate
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate
3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
(+)-alpha -Tocopherol acetate
(+)-alpha -Tocopheryl acetate
(+)-alpha-Tocopherol acetate
(+)-alpha-tocopherol acetate
(+)-alpha-Tocopheryl acetate
(+)-alpha-tocopheryl acetate
(+)-α-tocopherol acetate
(+)-α-tocopheryl acetate
(+-)-alpha-Tocopherol acetate
(+-)-alpha-tocopherol acetate
a-Tocopherol acetate
a-Tocopherol acetic acid
alpha-Tocopherol acetic acid
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-
Vitamin E acetate; 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
α-Tocopherol acetate
(+)-α-Tocopherol acetate
(+)-α-Tocopheryl acetate
D-α-tocopherol acetate
D-α-tocopheryl acetate
Alfacol
Combinal E
Contopheron
E-Ferol
E-Toplex
Ecofrol
Econ
Endo E Dompe
Ephynal acetate
Epsilan-M
Erevit
Evipherol
Fertilvit
Gevex
Juvela
Tocopherex
Tocophrin
Tofaxin; Tokoferol acetate
[2R-[2R*(4R,8R*)]]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
d-Vitamin E acetate
E-vicotrat
Spondyvit
(2R,4'R,8'R)-α-Tocopheryl acetate
(R,R,R)-α-Tocopheryl acetate
Copherol 1250
Covitol 1100
Covitol 1360
Tocopheryl acetate
Vitamin Ealpha acetate
(+)-alpha -Tocopherol acetate
(+)-alpha -Tocopheryl acetate
(+)-alpha-Tocopherol acetate
(+)-alpha-tocopherol acetate
(+)-alpha-Tocopheryl acetate
(+)-alpha-tocopheryl acetate
(+)-α-tocopherol acetate
(+)-α-tocopheryl acetate
(+-)-alpha-Tocopherol acetate
(+-)-alpha-tocopherol acetate
.alpha.-Tocopherol acetate
Tocopheryl acetate
Tocopheryl acetate,alpha
Alpha Tocopheryl Acetate
Tocopheryl
Jeen vitamin e
Univit-e acetate
O-acetyl--tocopherol
Copherol 1250 c
Aec tocopheryl acetate
Covitol 1100 c
CHEMBL3989859
2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol acetate
[2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate
D-α-Tocopheryl acetate
D-ALPHA-TOCOPHEROL ACETATE
Evipherol;dl-alpha-tocopheryl
α-Tocopherol acetate
D-A-TOCOPHERYL ACETATE
D-α-Tocopherol Acetate
D-alpha-Tocopheryl acetate,98%
Econ
Gevex
α-Tocopherol Acetate
(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol 6-Acetate
Ephynal Acetate
(+)-α-Tocopherol Acetate
(+)-α-Tocopheryl Acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, 6-acetate, (2R)
Vitamin E acetate; D-Alpha-tocopheryl acetate
D-a-Tocopherol acetate
(R,R,R)-a-Tocopheryl acetate
d-Vitamin E acetate
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
