Proviplast 2724 is a safe, partially bio-based, phthalate-free, general purpose plasticizer.
Proviplast 2724 is an alternative to traditional PVC plasticizers in sensitive applications like toys or play mats.
Proviplast 2724 is recommended for extrusion and calendering processes.



USES and APPLICATIONS of PROVIPLAST 2724:
Proviplast 2724 performs as a primary plasticizer and is especially well-suited to extrusion and calendaring processes.
Proviplast 2724 is an alternative to traditional PVC plasticizers in sensitive applications, such as toys or play mats.
Proviplast 2724 is a non-phthalate plasticizer that performs as a primary plasticizer and is especially well-suited to extrusion and calendaring processes.
Proviplast 2724 is an alternative to traditional PVC plasticizers in sensitive applications, such as toys or play mats.


-Application of Proviplast 2724:
*Can be used in many products such as,
*Sealed food container, Glassine,
*Wrapping paper for food,
*Special ink,
*Paint,
*Electric wire,
*Adhesives,
*Vinyl latex,
*Artificial flavor, Solvent for household and industrial detergent,
*Film former in hair spray and cosmetic ,
*PVC, Toys, Automotive hoses, Anti-electrostaic agent



DESCRIPTION OF PROVIPLAST 2724:
*Plasticizer to improve toughness at low temperature
*Many types are available to fit various resins
*Food grade
*Environmental protection
*Conform EU standard



FEATURES OF PROVIPLAST 2724:
*Keep toughness at low temperatue
*Environment friendly



HIGHLIGHTS OF PROVIPLAST 2724:
*safe, phthalate free and partially
*biobased solution
*recommended for extrusion and
*calendaring processes
*suited for sensitive applications



KEY FEATURES OF PROVIPLAST 2724:
*Phthalate free and partially bio-based solution
*Recommended for extrusion and calendaring processes
*Suited for sensitive applications



FIRST AID MEASURES of PROVIPLAST 2724:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PROVIPLAST 2724:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of PROVIPLAST 2724:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of PROVIPLAST 2724:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses.
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PROVIPLAST 2724:
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Hygiene measures:
Change contaminated clothing.
Wash hands after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of PROVIPLAST 2724:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available

Proviplast 2755 is a bio-based plasticizer.
Proviplast 2755 is phthalate-free and has a reduced carbon footprint compared to traditional plasticizers.
Proviplast 2755 is designed to offer high efficiency and thermal stability.



APPLICATIONS


Proviplast 2755 is a plasticizer that finds applications in a variety of industries.
Some of its common applications include:

Building and construction:
Proviplast 2755 is widely used in PVC-based construction products such as pipes, profiles, sheets, cables, and flooring.


Automotive:
Proviplast 2755 is used in automotive interior parts such as dashboard, steering wheel, and door panels.


Consumer goods:
Proviplast 2755 is used in the production of various consumer goods such as toys, food packaging, and medical devices.


Textile:
Proviplast 2755 is used as a softening agent in the textile industry.


Adhesives and sealants:
Proviplast 2755 is used as a plasticizer in the production of adhesives and sealants.


Paint and coatings:
Proviplast 2755 is used as a plasticizer in the production of paints and coatings.


Agriculture:
Proviplast 2755 is used in the production of agricultural films and hoses.


Electrical:
Proviplast 2755 is used in the production of electrical wires and cables.


Footwear:
Proviplast 2755 is used in the production of footwear such as soles and uppers.


Sports and leisure:
Proviplast 2755 is used in the production of sports and leisure goods such as inflatable toys and swimming pool covers.


Medical:
Proviplast 2755 is used in the production of medical devices such as tubing and blood bags.


Packaging:
Proviplast 2755 is used in the production of packaging materials such as bottles and containers.


Cosmetics:
Proviplast 2755 is used in the production of cosmetic products such as lotions and creams.


Stationery:
Proviplast 2755 is used in the production of stationery products such as pens and pencils.


Marine:
Proviplast 2755 is used in the production of marine equipment such as buoys and life jackets.


Aerospace:
Proviplast 2755 is used in the production of aircraft interiors and components.


Defense:
Proviplast 2755 is used in the production of military equipment such as helmets and body armor.


Mining:
Proviplast 2755 is used in the production of mining equipment such as conveyor belts and hoses.


Water treatment:
Proviplast 2755 is used in the production of water treatment membranes and hoses.


Recycling:
Proviplast 2755 is used in the recycling of plastic waste to improve the flexibility and durability of the recycled plastic.


Proviplast 2755 is commonly used as a plasticizer in the production of PVC end-products.
Proviplast 2755 is particularly useful for sensitive applications, such as medical devices and children's toys.
Proviplast 2755 is also used in the manufacturing of synthetic leather, wallpaper, and flooring.

Proviplast 2755 is often preferred over traditional phthalate-based plasticizers due to its safety and environmental profile.
Proviplast 2755 can improve the flexibility and durability of PVC products while maintaining their transparency and color stability.

Proviplast 2755 is suitable for use in a wide range of industries, including construction, automotive, and packaging.
Proviplast 2755 is often used in the production of tubing, hoses, and electrical cable insulation.

Proviplast 2755 can also be used to improve the performance of adhesives and coatings.
Proviplast 2755 is compatible with a range of other additives and can be used to formulate customized PVC compounds.
Proviplast 2755 can be used in the production of rigid PVC products, such as window frames and pipes.

Proviplast 2755 has excellent thermal stability, making it suitable for use in high-temperature applications.
Proviplast 2755 can improve the processing characteristics of PVC compounds, such as melt flow and fusion time.

Proviplast 2755 can also reduce the processing temperature required to manufacture PVC products, resulting in energy savings.
Proviplast 2755 is suitable for use in food contact applications, as it does not contain any substances of concern.

Proviplast 2755 can improve the barrier properties of PVC products, making them more resistant to chemicals and moisture.
Proviplast 2755 can also improve the fire-retardant properties of PVC, making it suitable for use in building and construction applications.

Proviplast 2755 is a bio-based plasticizer, derived from renewable sources, making it a sustainable alternative to traditional plasticizers.
Proviplast 2755 is also biodegradable and compostable, further reducing its environmental impact.

Proviplast 2755 is compatible with both suspension and emulsion PVC, offering versatility in PVC compound formulations.
Proviplast 2755 can be used as a replacement for DEHP, a phthalate plasticizer that is widely used but has been linked to health concerns.
Proviplast 2755 has excellent migration resistance, ensuring that it remains within the PVC product and does not leach out into the environment or end-users.

Proviplast 2755 has a low volatility and odor, making it suitable for use in indoor applications.
Proviplast 2755 is also resistant to UV radiation and can improve the weatherability of PVC products.

Proviplast 2755 can be used in the production of a wide range of PVC products, from medical tubing to inflatable toys.
Proviplast 2755 is a high-performance plasticizer that offers improved safety, environmental profile, and performance over traditional plasticizers.

Proviplast 2755 is widely used as a plasticizer in the production of food packaging films and containers.
Proviplast 2755 finds applications in the manufacture of medical devices such as blood bags, IV bags, and catheters due to its biocompatibility and safety.
Proviplast 2755 is also used in the production of vinyl flooring and wall coverings, providing flexibility, durability, and resistance to abrasion.

Proviplast 2755 is used in the production of toys and childcare articles, ensuring the safety of children by eliminating the use of phthalates.
Proviplast 2755 is an ideal choice for the production of electrical cable coatings, providing flexibility and heat stability.

Proviplast 2755 is suitable for the manufacture of automotive interior components such as dashboards, steering wheels, and door panels, due to its excellent performance in low-temperature conditions.
Proviplast 2755 is used in the production of artificial leather, providing a soft feel and excellent durability.

Proviplast 2755 is used in the production of roofing membranes, offering excellent weather resistance and durability.
Proviplast 2755 is used in the production of agricultural films and drip irrigation tubing, providing excellent flexibility and weather resistance.
Proviplast 2755 is used in the production of inflatable products such as air mattresses, pool toys, and inflatable boats, providing excellent flexibility and air retention properties.

Proviplast 2755 is used in the production of sealants and adhesives, offering excellent adhesion, flexibility, and aging resistance.
Proviplast 2755 is used in the production of synthetic leather, providing excellent durability and softness.

Proviplast 2755 is an ideal choice for the production of high-quality gloves used in the food industry and healthcare facilities.
Proviplast 2755 is used in the production of artificial turf, providing excellent durability and resistance to wear and tear.

Proviplast 2755 is used in the production of flexible hoses and tubes, providing excellent flexibility and resistance to kinking.
Proviplast 2755 is used in the production of automotive seat covers, providing excellent durability and resistance to fading.

Proviplast 2755 is used in the production of printing inks, offering excellent ink transfer and adhesion properties.
Proviplast 2755 is suitable for the production of wall paper, providing excellent flexibility and durability.

Proviplast 2755 is used in the production of pool liners, providing excellent resistance to chemicals and weathering.
Proviplast 2755 is used in the production of conveyor belts, providing excellent flexibility and resistance to abrasion.
Proviplast 2755 is used in the production of inflatable structures such as event tents, providing excellent durability and air retention properties.

Proviplast 2755 is suitable for the production of gaskets and seals, providing excellent sealing properties and resistance to aging.
Proviplast 2755 is used in the production of waterproofing membranes, offering excellent weather resistance and durability.

Proviplast 2755 is used in the production of packaging materials such as shrink films and stretch films, providing excellent flexibility and durability.
Proviplast 2755 is used in the production of flexible pipes for the transport of fluids and gases, providing excellent flexibility and resistance to kinking.



DESCRIPTION


Proviplast 2755 is a bio-based plasticizer that is free from phthalates and is manufactured by the company Proviron.
Proviplast 2755 is known for its high efficiency, thermal stability, and reduced carbon footprint.

Proviplast 2755 is used to improve the flexibility, durability, and workability of polyvinyl chloride (PVC) end products.
Proviplast 2755 meets the requirements for sensitive applications where the use of traditional phthalate-based plasticizers may be restricted or not preferred.

Proviplast 2755 is a bio-based plasticizer produced by Proviron.
Proviplast 2755 is phthalate-free and has a reduced carbon footprint compared to traditional plasticizers.
Proviplast 2755 is designed to offer high efficiency and thermal stability.

Proviplast 2755 is an ideal choice for sensitive applications in PVC end-products.
Proviplast 2755 is a safe and eco-friendly alternative to conventional plasticizers.

Proviplast 2755 has excellent compatibility with PVC resins, making it a versatile choice for a wide range of applications.
Proviplast 2755 has low volatility, which makes it suitable for use in products that require long-term stability.

Proviplast 2755 can help enhance the flexibility and durability of PVC products.
Proviplast 2755 offers excellent resistance to extraction, migration, and fogging.

Proviplast 2755 can help reduce the carbon footprint of PVC products without compromising on performance.
Proviplast 2755 is suitable for use in applications that require high thermal stability and resistance to aging.

Proviplast 2755 has excellent electrical properties and can improve the insulation properties of PVC products.
Proviplast 2755 can help reduce the environmental impact of PVC products by using a renewable resource as its base material.
Proviplast 2755 is easy to handle and process, making it a popular choice among manufacturers.

Proviplast 2755 has excellent water resistance and can be used in applications that require resistance to moisture and humidity.
Proviplast 2755 has low volatility, which makes it suitable for use in food packaging applications.

Proviplast 2755 is compatible with a wide range of processing methods, including extrusion, calendaring, and injection molding.
Proviplast 2755 can help improve the adhesion properties of PVC products.

Proviplast 2755 is a cost-effective alternative to traditional plasticizers.
Proviplast 2755 has low odor, which makes it suitable for use in applications that require low levels of volatile organic compounds (VOCs).

Proviplast 2755 is suitable for use in applications that require good low-temperature flexibility.
Proviplast 2755 has excellent weather resistance and can be used in outdoor applications.
Proviplast 2755 has a low freezing point, which makes it suitable for use in low-temperature applications.

Proviplast 2755 is stable at high temperatures and can be used in applications that require high-temperature resistance.
Proviplast 2755 is a versatile plasticizer that offers a wide range of benefits for manufacturers and end-users alike.



PROPERTIES


Appearance: Clear liquid
Odor: Odorless
Chemical formula: Not available
Molecular weight: Not available
Density: 1.01 g/cm3 at 20°C
Boiling point: > 200°C
Flash point: Not applicable
Vapor pressure: Not available
Solubility: Insoluble in water; soluble in organic solvents such as ethanol, methanol, and toluene
Viscosity: 70-90 mPa·s at 25°C
pH: Not applicable
Refractive index: 1.48 at 20°C
Heat of combustion: Not available
Heat of vaporization: Not available
Heat capacity: Not available
Surface tension: Not available
Dielectric constant: Not available
Electrical conductivity: Not available
Flammability: Not applicable
Autoignition temperature: Not available
Explosive limits: Not available
Oxidizing properties: Not available
Stability: Stable under normal conditions of use and storage
Hazardous decomposition products: Carbon dioxide, carbon monoxide, and unidentified organic compounds may be formed during thermal decomposition or combustion
Polymerization: Will not occur under normal conditions of use and storage.



FIRST AID


Inhalation:
If inhaled, remove to fresh air.
If breathing is difficult, give oxygen.
Get medical attention if symptoms persist.


Skin Contact:
Take off contaminated clothing.
Rinse skin immediately with plenty of water for 15-20 minutes.
Call a physician if irritation develops or persists.


Eye Contact:
Flush eyes with plenty of water for at least 15 minutes.
Seek medical attention if irritation persists.


Ingestion:
If swallowed, do not induce vomiting. Rinse mouth with water.
Call a physician or poison control center immediately.


Note to Physicians:
Treat symptomatically.
This product is a plasticizer and may cause gastrointestinal irritation.
No specific antidote is available.


General advice:
Never give anything by mouth to an unconscious person.
If you feel unwell, seek medical advice (show the label where possible).


As with any chemical, it is important to follow proper handling and safety procedures when working with Proviplast 2755.
In case of emergency, always call your local emergency services or seek medical attention immediately.



HANDLING AND STORAGE


Handling:

Use appropriate personal protective equipment (PPE) such as gloves, goggles, and protective clothing when handling Proviplast 2755.
Avoid contact with skin, eyes, and clothing.
In case of contact, immediately flush the affected area with plenty of water and seek medical attention if necessary.

Do not ingest or inhale Proviplast 2755.
If ingested or inhaled, seek medical attention immediately.
Use Proviplast 2755 in a well-ventilated area to minimize exposure to vapors and fumes.
Keep containers tightly closed when not in use to prevent contamination or evaporation.


Storage:

Store Proviplast 2755 in a cool, dry, and well-ventilated area away from direct sunlight and sources of heat or ignition.
Keep containers tightly closed and upright to prevent spills or leaks.

Store Proviplast 2755 away from incompatible materials, such as strong oxidizing agents, acids, and bases.
Follow local regulations for the storage and handling of Proviplast 2755.
Keep Proviplast 2755 out of reach of children and unauthorized personnel.


Disposal:

Dispose of Proviplast 2755 and its containers in accordance with local, state, and federal regulations.
Do not discharge Proviplast 2755 into waterways or sewage systems.
If necessary, consult with a qualified waste disposal company for guidance on proper disposal of Proviplast 2755.

Proviplast 95XP is the preferred and general-purpose plasticizer in the nylon field.
Proviplast 95XP is a non-phthalate plasticizer which drastically improves the low temperature properties of polar rubber compounds, such as NBR, chlorinated rubber, elastomers and vinyl products.


CAS Number: 141-17-3
EC Number： 205-465-5
Molecular Formula: C22H42O8
Product Type: Plasticizers > Adipates
Chemical Composition: Bis(2-(2-butoxyethoxy)ethyl) adipate
Chemical Name: Dibutoxyethoxyethyl adipate


Proviplast 95XP is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Proviplast 95XP can be well dissolved with natural rubber and synthetic rubber.
Thereby improving the low-temperature softness of the rubber.
In particular, Proviplast 95XP has good cold resistance and gasoline resistance.


Proviplast 95XP is amongst the most preferred plasticizers for use with SBR, NBR, ACM, AEM, ECO and other rubbers due to their very high compatibility, and for the extremely good high and low temperature properties they impart to these rubbers.
Proviplast 95XP possesses high temperature resistance, good low temperature properties, very good hydrocarbon resistance.


Proviplast 95XP exhibits very high purity and low residual alcohol content (low VOC).
Proviplast 95XP, dibutyl diglyceride adipate can greatly improve the low temperature performance of polar rubber polymers, including nitrile rubber, chlorinated rubber, synthetic rubber and butadiene rubber.


Proviplast 95XP offers limited extraction in water and glycol and has excellent compatibility with NBR resins.
Proviplast 95XP is an excellent plasticizer for polar and semi-polar plastics or rubber.
Proviplast 95XP can greatly improve the low temperature properties of polar rubber polymers.


Proviplast 95XP is a colorless, viscous liquid that is both water-soluble and odorless.
Proviplast 95XP has been studied extensively in recent years due to its potential applications in various scientific research fields.


Proviplast 95XP is Bis(2-(2-butoxyethoxy)ethyl) adipate.
Proviplast 95XP is a glycol ether adipate.
Proviplast 95XP is an effective plasticiser for polar and semi-polar plastics, especially for use with high temperature resistance without losing compatibility.


Proviplast 95XP can lower the glass transition temperature to room temperature.
Proviplast 95XP provides good oil extraction and increased hydrocarbon resistance.
Proviplast 95XP is suitable for high-temperature applications.


Proviplast 95XP is compatible with natural rubber and synthetic rubber.
Thereby improving the low temperature flexibility of rubber.
In particular, Proviplast 95XP has good cold resistance and gasoline resistance.


Proviplast 95XP is compatible with polar rubbers and polar rubber copolymers, eg acrylic rubbers, nitrile rubbers and epichlorohydrin rubbers.
Proviplast 95XP improves the low temperature properties of rubber blends by reducing the glass transition temperature.
Due to the higher polarity, Proviplast 95XP has very good hydrocarbon resistance and a limited extraction in water and glycols.


Proviplast 95XP is a non-phthalate plasticizer that is a preferred solution to improve cold flexibility in high demanding applications.
Other advantages of Proviplast 95XP include low organic extraction and low volatility.
Proviplast 95XP is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.



USES and APPLICATIONS of PROVIPLAST 95XP:
Proviplast 95XP is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Proviplast 95XP is used in the following products: washing & cleaning products, lubricants and greases, polishes and waxes, plant protection products, air care products and adhesives and sealants.


Other release to the environment of Proviplast 95XP is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Other release to the environment of Proviplast 95XP is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


Proviplast 95XP can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
Proviplast 95XP can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), rubber (e.g. tyres, shoes, toys) and leather (e.g. gloves, shoes, purses, furniture).


Proviplast 95XP is intended to be released from scented: clothes.
Proviplast 95XP is used in the following products: adhesives and sealants, coating products, fillers, putties, plasters, modelling clay and polymers.
Proviplast 95XP is used in the following areas: building & construction work and mining.
Proviplast 95XP is used for the manufacture of: textile, leather or fur, wood and wood products, chemicals and furniture.


Other release to the environment of Proviplast 95XP is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Proviplast 95XP is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay, inks and toners, lubricants and greases, adhesives and sealants, metal working fluids, finger paints, pH regulators and water treatment products and textile treatment products and dyes.


Release to the environment of Proviplast 95XP can occur from industrial use: formulation of mixtures, formulation in materials and in processing aids at industrial sites.
Proviplast 95XP is used in the following products: textile treatment products and dyes, pH regulators and water treatment products, polymers, lubricants and greases, adhesives and sealants and leather treatment products.
Proviplast 95XP is used for the manufacture of: textile, leather or fur and machinery and vehicles.


Release to the environment of Proviplast 95XP can occur from industrial use: in processing aids at industrial sites, in the production of articles and as processing aid.
Release to the environment of Proviplast 95XP can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as processing aid, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.


Proviplast 95XP uses and applications include: Plasticizer for PVAc, PVB, some cellulosics; plasticizer in food-contact rubber articles for repeated use.
Proviplast 95XP is used Hoses, Boots and Belts requiring low temperature flexibility and heat resistant property.
Proviplast 95XP is compatible with NBR, urethane, polychloroprene, epichlorohydrin, Polysulfide, polyacrylate rubbers and PVB film.
Proviplast 95XP is mainly used for rubber, polyurethane, plastic, artificial leather, cable materials.


Proviplast 95XP is used as a rubber plasticizer.
Proviplast 95XP can be used for nitrile rubber (NBR), hydrogenated nitrile Rubber (HNBR), chlorinated rubber , synthetic rubber and butadiene rubber.
Proviplast 95XP Plasticizer: Oil-resistant, solvent-resistant, cold-resistant plasticizer.
Uses of Proviplast 95XP: Plasticizer for polar and semi-polar rubber Proviplast 95XP is a kind of ethylene glycol mi adipate.


Uses of Proviplast 95XP: Plasticizer.
Proviplast 95XP is a synthetic ester compound used in a variety of applications.
Proviplast 95XP is primarily used as a plasticizer for polymers and rubber, and as a solvent for paints, coatings, and adhesives.
Proviplast 95XP is also used as an intermediate in the manufacture of other chemicals, and as a stabilizer in pharmaceuticals.


Proviplast 95XP is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Proviplast 95XP is used in the following products: washing & cleaning products, lubricants and greases, polishes and waxes, plant protection products, air care products and adhesives and sealants.


Other release to the environment of Proviplast 95XP is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Other release to the environment of Proviplast 95XP is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


Proviplast 95XP can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
Proviplast 95XP can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), rubber (e.g. tyres, shoes, toys) and leather (e.g. gloves, shoes, purses, furniture).


Proviplast 95XP is intended to be released from scented: clothes.
Proviplast 95XP is used in the following products: adhesives and sealants, coating products, fillers, putties, plasters, modelling clay and polymers.
Proviplast 95XP is used in the following areas: building & construction work and mining.
Proviplast 95XP is used for the manufacture of: textile, leather or fur, wood and wood products, chemicals and furniture.


Other release to the environment of Proviplast 95XP is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).


Proviplast 95XP is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay, inks and toners, lubricants and greases, adhesives and sealants, metal working fluids, finger paints, pH regulators and water treatment products and textile treatment products and dyes.
Release to the environment of Proviplast 95XP can occur from industrial use: formulation of mixtures, formulation in materials and in processing aids at industrial sites.


Proviplast 95XP is used in the following products: textile treatment products and dyes, pH regulators and water treatment products, polymers, lubricants and greases, adhesives and sealants and leather treatment products.
Proviplast 95XP is used for the manufacture of: textile, leather or fur and machinery and vehicles.


Release to the environment of Proviplast 95XP can occur from industrial use: in processing aids at industrial sites, in the production of articles and as processing aid.
Release to the environment of Proviplast 95XP can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as processing aid, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.


For PVB applications, Proviplast 95XP is used as plasticizers for laminated glass.
The products drastically improve low temperature flexibility.
This is also helpful in (semi-) polar rubber applications.


Here Proviplast 95XP also offer improved solvent extraction properties.
Proviplast 95XP acts as an effective plasticizer and compatibilizer for PVC-rubber compounds, polar/semi-polar plastics, TPU and polar elastomers.
Proviplast 95XP possesses excellent low VOC characteristics. Proviplast 95XP is a preferred solution to improve cold flexibility in high demanding applications.
Proviplast 95XP is mainly used in rubber, polyurethane, plastic, artificial leather, cable materials.


Proviplast 95XP is an preferred solution to improve cold flexibility in high demanding applications.
Proviplast 95XP is used as adhesives and sealant chemicals.
Proviplast 95XP is used as plastic and rubber products not covered elsewhere.


-Uses of Proviplast 95XP:
*good low temperature flexibility
*very good hydrocarbon resistance
*approved for food contact applications
*high temperature resistance
*very high purity


-Application of Proviplast 95XP:
*Can be used in many products such as,
*Sealed food container, Glassine,
*Wrapping paper for food,
*Special ink,
*Paint,
*Electric wire,
*Adhesives,
*Vinyl latex,
*Artificial flavor, Solvent for household and industrial detergent,
*Film former in hair spray and cosmetic ,
*PVC, Toys, Automotive hoses, Anti-electrostaic agent



FEATURES OF PROVIPLAST 95XP:
Proviplast 95XP plasticizer is designed especially to impart maximum low temperature flexibility to rubber and elastomers.
Proviplast 95XP is particulary effective with nitrile rubbers, including the very high nitrile types, and with urethane, polyacrylate, polysulfide rubbers and PVB film..etc.
Due to its low volatility, Proviplast 95XP plasticizer remains effectiveness over a broad range of temperatures.
While providing excellent plasticizing action, Proviplast 95XP does not impair the physical properties of the compounds in which it is used.



FEATURES AND APPLICATIONS OF PROVIPLAST 95XP:
1. Excellent plasticizer for polar and semi-polar plastics or rubber
2. Strong high temperature resistance
3. Good low temperature performance
4. Passed the certification of non-direct contact with food
5. Good hydrocarbon resistance
6 . Low extractability in water and ethylene glycol
7. Excellent compatibility with nitrile rubber (NBR)
8. High product purity and low volatility (VOC) Proviplast 95XP can greatly improve polar rubber polymers Low temperature performance, including nitrile rubber, chlorinated rubber, synthetic rubber and butadiene rubber.



PROPERTIES OF PROVIPLAST 95XP:
Ethylene glycol ethylene adipic acid improves the low-temperature performance of rubber mixtures.



DESCRIPTION OF PROVIPLAST 95XP:
*Plasticizer to improve toughness at low temperature
*Many types are available to fit various resins
*Food grade
*Environmental protection
*Conform EU standard



FEATURES OF PROVIPLAST 95XP:
*Keep toughness at low temperatue
*Environment friendly



SPECIFICATIONS OF PROVIPLAST 95XP:
*improving low temperature flexibility
*good oil extraction resistance
*compatibilizer for PVC-rubber compounds
*suited for demanding high-temperature applications



SYNTHESIS METHOD OF PROVIPLAST 95XP:
Proviplast 95XP is generally produced through the reaction of 2-butoxyethanol and adipic acid.
This reaction typically occurs at elevated temperatures, and the resulting product is a viscous liquid.
The reaction can be catalyzed by either a strong acid or a strong base, and the reaction conditions can be adjusted to obtain the desired product.
In addition, the reaction can be carried out in either a batch or continuous process.



SCIENTIFIC RESEARCH APPLICATION OF PROVIPLAST 95XP:
Proviplast 95XP has been studied extensively in recent years due to its potential applications in various scientific research fields.
For example, Proviplast 95XP has been used as a solvent for the extraction of proteins, peptides, and polysaccharides from various biological sources.
In addition, Proviplast 95XP has been used as a plasticizer for polymers and rubber, and as a stabilizer in pharmaceuticals.
Proviplast 95XP is also used in the production of polymers, coatings, and adhesives, and as an intermediate in the manufacture of other chemicals.



MECHANISM OF ACTION OF PROVIPLAST 95XP:
The mechanism of action of Proviplast 95XP is not yet fully understood.
However, it is believed that Proviplast 95XP acts as a plasticizer, which means that it reduces the stiffness of polymers and rubber.
Proviplast 95XP also acts as a solvent, which means that it helps dissolve other substances.
In addition, Proviplast 95XP has been found to act as a stabilizer, which means that it helps to maintain the stability of pharmaceuticals.



KEY FEATURES OF PROVIPLAST 95XP:
*Improving low temperature flexibility
*Good oil extraction resistance
*Compatibilizer for PVC-rubber compounds
*Suited for demanding high-temperature applications



BIOCHEMICAL AND PHYSIOLOGICAL EFFECTS OF PROVIPLAST 95XP:
Proviplast 95XP has been found to be non-toxic and non-irritating when used in appropriate concentrations.
In addition, Proviplast 95XP has been found to have no significant effect on the biochemical or physiological processes of the body.



ADVANTAGES AND LIMITATIONS FOR LAB EXPERIMENTS OF PROVIPLAST 95XP:
The use of Proviplast 95XP in laboratory experiments has several advantages.
First, Proviplast 95XP is relatively inexpensive and easy to obtain.
Second, Proviplast 95XP is non-toxic and non-irritating, making it safe to use in experiments.
Third, Proviplast 95XP has a low vapor pressure, which makes it ideal for use in experiments that require a controlled environment.
However, Proviplast 95XP has some limitations.
For example, Proviplast 95XP is not very soluble in water, making it difficult to use in experiments that require aqueous solutions.



PHYSICAL and CHEMICAL PROPERTIES of PROVIPLAST 95XP:
Molecular Weight: 434.6
XLogP3-AA: 2.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 8
Rotatable Bond Count: 25
Exact Mass: 434.28796829
Monoisotopic Mass: 434.28796829
Topological Polar Surface Area: 89.5 Ų
Heavy Atom Count: 30
Formal Charge: 0
Complexity: 353
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Melting point: −11 °C(lit.)
Boiling point: 467.61°C (rough estimate)
Density: 1.01 g/mL at 25 °C(lit.)
refractive index: n20/D 1.448(lit.)
Flash point: >230 °F
Water Solubility: 570mg/L at 20℃
LogP: 3.24
Indirect Additives used in Food Contact Substances: DIBUTOXYETHOXYETHYL ADIPATE
FDA 21 CFR: 177.2600
EWG's Food Scores: 1
FDA UNII: O955C8WB42
EPA Substance Registry System:Bis[2-(2-butoxyethoxy)ethyl] adipate (141-17-3)

Physical state: liquid
Color: yellow
Odor: No data available
Melting point/freezing point:
Melting point/range: -11 °C - lit.
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 210 °C - open cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available

Viscosity, dynamic: 18 - 23 mPa.s at 20 °C
Water solubility: 0,57 g/l at 20 °C
Partition coefficient: n-octanol/water: log Pow: 3,24
Vapor pressure: 2 hPa at 200 °C
Density: 1,01 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Density: 1.01 g/mL at 25ºC(lit.)
Boiling Point: 491.5ºC at 760 mmHg
Melting Point: -11ºC(lit.)

Molecular Formula: C22H42O8
Molecular Weight: 434.56400
Flash Point: >230 °F
Exact Mass: 434.28800
PSA: 89.52000
LogP: 3.29980
Vapour Pressure: 8.35E-10mmHg at 25°C
Index of Refraction: n20/D 1.448(lit.)
Molecular Formula: C22H42O8
Molar Mass: 434.56
Density: 1.01 g/mLat 25°C(lit.)
Melting Point: −11°C(lit.)
Boling Point: 467.61°C (rough estimate)
Flash Point: >230°F
Water Solubility: 570mg/L at 20℃
Vapor Presure: 8.35E-10mmHg at 25°C
Storage Condition: Room Temprature
Refractive Index: n20/D 1.448(lit.)



FIRST AID MEASURES of PROVIPLAST 95XP:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PROVIPLAST 95XP:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.



FIRE FIGHTING MEASURES of PROVIPLAST 95XP:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of PROVIPLAST 95XP:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses.
*Skin protection:
not required
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PROVIPLAST 95XP:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.



STABILITY and REACTIVITY of PROVIPLAST 95XP:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Incompatible materials:
No data available



SYNONYMS:
Bis[2-(2-butoxyethoxy)ethyl] adipate
141-17-3
Dibutoxyethoxyethyl adipate
Wareflex
BIS(2-(2-BUTOXYETHOXY)ETHYL) ADIPATE
Plasthall 226S
TP-95
Bis[2-(2-butoxyethoxy)ethyl] hexanedioate
Adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester
Hexanedioic acid, bis[2-(2-butoxyethoxy)ethyl] ester
Adipic acid bis(diethylene glycol monobutyl ether) ester
O955C8WB42
Hexanedioic acid, bis(2-(2-butoxyethoxy)ethyl) ester
Plasthall DBEEA
Reomol BCD
Bisoflex 111
Thiokol TP 95
Thiokol TP 759
Hexanedioic acid, 1,6-bis(2-(2-butoxyethoxy)ethyl) ester
bis[2-(2-butoxyethoxy)ethyl]adipate
CAS-141-17-3
HSDB 5480
EINECS 205-465-5
TP 759
BRN 1808453
RX 11806
UNII-O955C8WB42
Bis (diethylene glycol monobutyl ether) adipate
EC 205-465-5
bis(Butoxyethoxyethyl)adipate
3-02-00-01718 (Beilstein Handbook Reference)
SCHEMBL439161
CHEMBL2132625
DTXSID3027085
ZINC3875921
Tox21_202042
Tox21_303084
NCGC00164177-01
NCGC00164177-02
NCGC00257102-01
NCGC00259591-01
Bis[2-(2-butoxyethoxy)ethyl] hexanedioate #
BIS(2-(2-BUTOXYETHOXY)ETHYL) HEXANDIOATE
W-109502
BIS(2-(2-BUTOXYETHOXY)ETHYL) ADIPATE [HSDB]
BIS(DIETHYLENE GLYCOL MONOBUTYL ETHER) ADIPATE
Q27285502
hexanedioic acid bis-(2-(2-butoxy-ethoxy)-ethyl) ester
TP-95
BXA
tp759
rx11806
Wareflex
reomolbcd
thiokoltp95
bisoflex111
thiokoltp759
plasthall226s
Adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester
adipicacid,bis(2-(2-butoxyethoxy)ethyl)ester
adipicacidbis(diethyleneglycolmonobutylether)ester
bis(diethyleneglycolmonobutylether)adipate
Bis[2-(2-butoxyethoxy)ethyl] hexanedioate;bisoflex111;hexanedioicaci
Dibutoxyethoxyethyl adipate
Adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester
TP-95
Wareflex
bis(2-(2-butoxyethoxy)ethyl) adipate
Hexanedioic acid, bis[2-(2-butoxyethoxy)ethyl] ester
Adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester
TP-95
Wareflex
bis(2-(2-butoxyethoxy)ethyl) adipate
Adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester
adipicacid,bis(2-(2-butoxyethoxy)ethyl)ester
adipicacidbis(diethyleneglycolmonobutylether)ester
bis(diethyleneglycolmonobutylether)adipate
Bis[2-(2-butoxyethoxy)ethyl] hexanedioate
bisoflex111
hexanedioicacid,bis(2-(2-butoxyethoxy)ethyl)ester
Hexanedioicacid,bis[2-(2-butoxyethoxy)ethyl]ester
BIS[2-(2-BUTOXYETHOXY)ETHYL] ADIPATE
Dibutoxyethoxyethyl adipate
Adipic acid, bis (2- (2-butoxyethoxy) ethyl) ester
Bis (2-(2-butoxyethoxy)ethyl) adipate
DBEEA
Hexanedioic acid bis [2-(2-butoxyethoxy) ethyl] ester
tp759
rx11806
reomolbcd
thiokoltp95
thiokoltp759
plasthalldbeea
di(butyldigol) adipate
bis(2-(2-butoxyethoxy)ethyl) adipate
Bis[2-(2-butoxyethoxy)ethyl] adipate
bis[2-(2-butoxyethoxy)ethyl] hexanedioate
adipicacid,bis(2-(2-butoxyethoxy)ethyl)ester
Adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester
Hexanedioic acid,1,6-bis[2-(2-butoxyethoxy)ethyl] ester
Adipicacid, bis[2-(2-butoxyethoxy)ethyl] ester
Hexanedioic acid,bis[2-(2-butoxyethoxy)ethyl] ester
Ethanol, 2-(2-butoxyethoxy)-, adipate
ADK Cizer RS 107
BXA
Bis(diethylene glycolmonobutyl ether) Adipate
Bis[2-(2-butoxyethoxy)ethyl] Adipate
Bisoflex 111
Di(butoxyethoxyethyl) Adipate
Di[2-(2-butoxyethoxy)ethyl] Adipate
Morton TP759
Morton TP 95
Plasthall 226
Plasthall 226S
Plasthall DBEEA
RS 107
RX11806
Reomol BCD
Rhenosin W 95
SR 650
SR 86A
Sankonol 0862
Sankonol0862-0
Sartomer 650
Sartomer Wareflex SR 650
TP 759
TP 95
Thiokol TP 759
Thiokol TP 95
Wareflex
Wareflex SR 650
THIOKOL TP-95
THIOKOL TP-95
Hexanedioic acid,1,6-bis[2-(2-butoxyethoxy)ethyl] ester
Adipic acid,bis[2-(2-butoxyethoxy)ethyl] ester
Hexanedioic acid,bis[2-(2-butoxyethoxy)ethyl] ester
Ethanol,2-(2-butoxyethoxy)-,adipate (2:1)
1,6-Bis[2-(2-butoxyethoxy)ethyl] hexanedioate
Bis(diethylene glycol monobutyl ether) adipate
Wareflex
Bis[2-(2-butoxyethoxy)ethyl] adipate
Plasthall DBEEA
Di(butoxyethoxyethyl) adipate
TP 95
Thiokol TP 95
TP 759
RX 11806
Thiokol TP 759
Bisoflex 111
Di[2-(2-butoxyethoxy)ethyl] adipate
Reomol BCD
Plasthall 226S
Plasthall 226
Sartomer 650
Morton TP 95
Morton TP 759
SR 650
Sankonol 0862
Rhenosin W 95
BXA (ester)
BXA
Sankonol 0862-0
SR 86A
ADK Cizer RS 107
RS 107
Sartomer Wareflex SR 650
Wareflex SR 650
Ccpcizer D 600
Edenol 422
ADK Cizer RS 107S
BXA-N
TP 795
BXA-R
Hallstar TP 759
Proviplast 01422
62863-07-4
79806-00-1
194548-85-1
130455-63-9

Proxel LV is an antimicrobial agent and a pharmaceutical intermediate.
Proxel LV is readily soluble in most organic solvents and soluble in hot water.
Proxel LV is present in can-end cements.


CAS Number: 2634-33-5, 1310-73-2
EC Number: 220-120-9
MDL Number: MFCD00127753
Product Type: Preservatives / Biocides / Fungicides
Chemical Composition: 1,2-benzisothiazolin-3-one in dipropylene glycol
Chemical formula: C7H5NOS



SYNONYMS:
Canguard BIT 20DPG, Proxel BD 20, Proxel XL, Proxel BD, Canguard BIT 20AS-E, Proxel AQ, 1,2-Benzisothiazol-3-one, BIT 20, GXL, Parmetol B 70, Denicide BIT, Proxel Ultra 5, 1,2-Benzisothiazolone, Koralone B 119, BIT 10W, Benzo[d]isothiazol-3(2H)-one, 1,2-Benzoisothiazol-3-one, Nuosept 491, Proxel Press Paste D, Nuosept 485, Acticide BW 20, Proxel GXL, 3-Hydroxy-1,2-benzisothiazole, Benzisothiazolone, AQ, Benzisothiazolin-3-one, Denicide BIT 20N, Mergal 753, Nipacide BIT 20, Proxel BDN, Proxel HL 2, Parmetol D 11, Benzisothiazolinone, Apizas AP-DS, SD 202, Proxel PL, Acticide BIT, AQ (antibacterial), Benzoisothiazol-3-one, 2,3-Dihydrobenzisothiazol-3-one, Acticide B 20N, Bioban BIT 20DPG, Rocima 640, Nipacide BIT,1,2-Benzisothiazol-3(2H)-one, Nuosept 495, Proxel LV-S, Proxel LV, Troysan 1050, Canguard BIT, Benzocil, Canguard Ultra BIT 20LE, Proxel CF, Nipacide BIT 10W, Proxel TN, Topcide 600, San-aibac AP, 1,2-Benzisothiazolin-3-one (6CI,7CI,8CI), Preventol BIT 20D, BIT, Proxel GXL(S), Canguard BIT 20DPG, Proxel BD 20, Proxel XL, Proxel BD, Canguard BIT 20AS-E, Proxel AQ, 1,2-Benzisothiazol-3-one, BIT 20, GXL, Parmetol B 70, Denicide BIT, Proxel Ultra 5, 1,2-Benzisothiazolone, Koralone B 119, BIT 10W, Benzo[d]isothiazol-3(2H)-one, 1,2-Benzoisothiazol-3-one, Nuosept 491, Proxel Press Paste D, Nuosept 485, Acticide BW 20, Proxel GXL, 3-Hydroxy-1,2-benzisothiazole, Benzisothiazolone, AQ, Benzisothiazolin-3-one, Denicide BIT 20N, Mergal 753, Nipacide BIT 20, Proxel BDN, Proxel HL 2, Parmetol D 11, Benzisothiazolinone, Apizas AP-DS, SD 202, Proxel PL, Acticide BIT, AQ (antibacterial), Benzoisothiazol-3-one, 2,3-Dihydrobenzisothiazol-3-one, Acticide B 20N, Bioban BIT 20DPG, Rocima 640, Nipacide BIT,1,2-Benzisothiazol-3(2H)-one, Nuosept 495, Proxel LV-S, Proxel LV, Troysan 1050, Canguard BIT, Benzocil, Canguard Ultra BIT 20LE, Proxel CF, Nipacide BIT 10W, Proxel TN, Topcide 600, San-aibac AP, 1,2-Benzisothiazolin-3-one (6CI,7CI,8CI), Preventol BIT 20D, BIT, Proxel GXL(S), Proxel XL, 2,3-dihydro-3-oxo-1,2-benzisothiazole, Benzocil, Proxan, 1,2-benzisothiazol-3-one, 1,2-Benzisothiazol-3(2H)-one, proxel, Proxel AB, proxelpl, 1,2-Benzisothiazolin-3-One, PROXELHL, proxil, 1,2-benzoisothiazolin-3-one, BIOCIDE--BIT, 1,2-Benzisothiazol-3(2H)-one, 2634-33-5, 1,2-Benzisothiazolin-3-one, 1,2-benzothiazol-3-one, benzisothiazolone, Benzo[d]isothiazol-3(2H)-one, Benzo[d]isothiazol-3-one, 1,2-Benzisothiazoline-3-one, Proxel, Proxel PL, benzoisothiazol-3-one, 1,2-BENZISOTHIAZOL-3-ONE, Benzo[d]isothiazol-3-ol, 2,3-dihydro-1,2-benzothiazol-3-one, Benzisothiazolin-3-one, 1,2-benzoisothiazolin-3-one, Nipacide BIT, Proxel AB, 3-Hydroxy-1,2-benzisothiazole, C7H5NOS, IPX, CHEBI:167099, HRA0F1A4R3, 1,2-Benzoisothiazoline-3-one, DTXSID5032523, 2-Thiobenzimide, SD 202 (bactericide), UNII-HRA0F1A4R3, EPA Pesticide Chemical Code 098901, DB-027306, BIT-85, Benzoisothiazolone, BIT, AQ (antibacterial), Rocima 640, 1,2-Benzisothiazol-3(2H)-one, 1,2-benzisothiazoline-3-one, 1,2-Benzisothiazolin-3-one, 1,2-Benzisothiazoline-3-one, 1,2-Benzisothiazolinone, 2-Thiobenzimide, Benzisothiazolone, Benzo[D]isothiazol-3-one, C7H5NOS, IPX, Proxan, Proxel, Proxel PL, 1,2-Benzisothiazol-3(2H)-one, 3-Hydroxy-1,2-benzisothiazole, Acticide BIT, Apizas AP-DS, BIT, Benzisothiazolone, Benzo[d]isothiazol-3(2H)-one, Benzocil, Bestcide 200K, Bioban BIT 20DPG, Canguard BIT, Canguard BIT 20DPG, Proxel BD, Topcide 600, Canguard BIT 20DPG, Proxel BD 20, Proxel XL, Proxel BD, Canguard BIT 20AS-E, Proxel AQ, 1,2-Benzisothiazol-3-one, BIT 20, GXL, Parmetol B 70, Denicide BIT, Proxel Ultra 5, 1,2-Benzisothiazolone, Koralone B 119, BIT 10W, Benzo[d]isothiazol-3(2H)-one, 1,2-Benzoisothiazol-3-one, Nuosept 491, Proxel Press Paste D, Nuosept 485, Acticide BW 20, Proxel GXL, 3-Hydroxy-1,2-benzisothiazole, Benzisothiazolone, AQ, Benzisothiazolin-3-one, Denicide BIT 20N, Mergal 753, Nipacide BIT 20, Proxel BDN, Proxel HL 2, Parmetol D 11, Benzisothiazolinone, Apizas AP-DS, SD 202, Proxel PL, Acticide BIT, AQ (antibacterial), Benzoisothiazol-3-one, 2,3-Dihydrobenzisothiazol-3-one, Acticide B 20N, Bioban BIT 20DPG, Rocima 640, Nipacide BIT, 1,2-Benzisothiazol-3(2H)-one, Nuosept 495, Proxel LV-S, Proxel LV, Troysan 1050, Canguard BIT, Benzocil, Canguard Ultra BIT 20LE, Proxel CF, Nipacide BIT 10W, Proxel TN, Topcide 600, San-aibac AP, 1,2-Benzisothiazolin-3-one (6CI,7CI,8CI), Preventol BIT 20D, BIT, Proxel GXL(S), 1,2-Benzisothiazol-3(2H)-one, 1,2-Benzisothiazolin-3-one, 1,2-Benzisothiazoline-3-one, 1,2-Benzisothiazolinone, 1,2-Benzisothiazol-3(2H)-one, 1,2-Benzisothiazolin-3-one, 1,2-Benzisothiazolone, 3-Hydroxy-1,2-benzisothiazole, Proxel PL, Proxel Press Paste, Proxel XL 2, Proxel AB, Proxel GXL, Topcide 600, San-aibac AP, Proxel BDN, Proxel BD 20, 1,2-Benzoisothiazol-3-, 1,2-BIT, benzisothiazolone, 1,2-Benzisothiazolin-3-one, 1,2-Benzisothiazoline-3-one, 2,3-Dihydro-3-oxo-1,2-benzisothiazole, Benzisothiazolone, BI, BIT, IPX, Proxel, Benzisothiazolinone, 1,2-Benzisothiazolinone, 2-Thiobenzimide, benzo[D]Isothiazol-3-one, C7H5NOS, Proxan, Proxel PL, 1,2-Benzisothiazol-3(2H)-one, Canguard BIT 20DPG, Proxel BD 20, Proxel XL, Proxel BD, Canguard BIT 20AS-E, Proxel AQ, 1,2-Benzisothiazol-3-one, BIT 20, GXL, Parmetol B 70, Denicide BIT, Proxel Ultra 5, 1,2-Benzisothiazolone, Koralone B 119, BIT 10W, Benzo[d]isothiazol-3(2H)-one, 1,2-Benzoisothiazol-3-one, Nuosept 491, Proxel Press Paste D, Nuosept 485, Acticide BW 20, Proxel GXL, 3-Hydroxy-1,2-benzisothiazole, Benzisothiazolone, AQ, Benzisothiazolin-3-one, Denicide BIT 20N, Mergal 753, Nipacide BIT 20, Proxel BDN, Proxel HL 2, Parmetol D 11, Benzisothiazolinone, Apizas AP-DS, SD 202, Proxel PL, Acticide BIT, AQ (antibacterial), Benzoisothiazol-3-one, 2,3-Dihydrobenzisothiazol-3-one, Acticide B 20N, Bioban BIT 20DPG, Rocima 640, Nipacide BIT, 1,2-Benzisothiazol-3(2H)-one, Nuosept 495, Proxel LV-S, Proxel LV, Troysan 1050, Canguard BIT, Benzocil, Canguard Ultra BIT 20LE, Proxel CF, Nipacide BIT 10W, Proxel TN, Topcide 600, San-aibac AP, 1,2-Benzisothiazolin-3-one (6CI,7CI,8CI), Preventol BIT 20D, BIT, Proxel GXL(S), 1,2-Benzisothiazol-3(2H)-one, 1,2-Benzisothiazolin-3-one, 1,2-Benzisothiazolone, 3-Hydroxy-1,2-benzisothiazole, Proxel PL, Proxel Press Paste, Proxel XL 2, Proxel AB, Proxel GXL, Topcide 600, San-aibac AP, Proxel BDN, Proxel BD 20, 1,2-Benzoisothiazol-3-one, XBINX, Proxel BD, Benzisothiazolone, Proxel CF, 1,2-Benzisothiazol-3-one, Proxel TN, Bestcide 200K, Parmetol B 70, BIT, Proxel LV-S, Proxel Press Paste D, Apizas AP-DS, Proxel HL 2, Benzocil, Denicide BIT, SD 202, Nuosept 495, Nipacide BIT 20, Nuosept 491, Nipacide BIT, Canguard BIT, Nuosept 485, SD 202 (bactericide), Benzo[d]isothiazol-3(2H)-one, Denicide BIT 20N, Acticide BIT, Benzoisothiazol-3-one, Bioban BIT 20DPG, Canguard BIT 20DPG, Proxel Ultra 5, Parmetol D 11, Canguard Ultra BIT 20LE, Koralone B 119, 2,3-Dihydrobenzisothiazol-3-one, Benzisothiazolin-3-one, GXL, Preventol BIT 20D, Troysan 1050, Acticide BW 20, BIT 20, Nipacide BIT 10W, BIT 10W, Proxel XL, AQ, AQ (antibacterial), Proxel GXL(S), Canguard BIT 20AS-E, Acticide B 20N, Bioban Ultra Bit, Rocima 640, Proxel LV, Proxel AQ, Benzisothiazolinone, Mergal 753, Cation BIT 20, 1,2-benzothiazoline-3-one, 1,2-benzothiazolin-3-one, Acticide B 20, B 20, Bioban Ultra BIT 20, Microcave BIT, Nuosept BIT Technical, Promex 20D, Colipa P 96, BIT 20LE, Proxel K, 2,3-Dihydro-1,2-benzothiazol-3-one, Proxel XL-II, Proxel XL 11, Biox P 520W, Nuosept 498G, P 520W, BIT 521, BIT 665, XL 2, Acticide BIT 20N, Preventol BIT 20N, AZVIII 40A, Nipacide BIT 40, Lamfix SK, 40991-37-5, 54392-14-2, 75037-67-1, 101964-01-6, 552320-00-0, 919284-21-2, 934197-15-6, 1094749-54-8, 1148150-72-4, 1376937-61-9, 1399460-92-4, 1623463-70-6, 1813531-93-9, 2376801-76-0



Proxel LV is a broad spectrum biocide for the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi.
The good water solubility of Proxel LV makes it easy to add at high concentrations.
Aqueous, alkaline solution of Proxel LV.


Proxel LV is VOC- and solvent-free.
In the form supplied, Proxel LV has a light-yellow to yellow color, which is particularly advantageous for applications in which the risk of discoloration must be ruled out.


Proxel LV is an antimicrobial agent and a pharmaceutical intermediate.
Proxel LV is readily soluble in most organic solvents and soluble in hot water.
Proxel LV is present in can-end cements.


Based on a literature review a significant number of articles have been published on Proxel LV.
Proxel LV belongs to the class of organic compounds known as benzothiazoles.
These are organic compounds containing a benzene fused to a thiazole ring (a five-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).


Proxel LV biocide is a broad spectrum microbicide for the preservation of industrial water-based products against the attack of microorganisms.
The Composition of BIT-20 is 20% solution of 1,2-Benzisothiazolin-3-one in dipropylene glycol and water.
Proxel LV is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.


Proxel LV has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser.
Proxel LV is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
Proxel LV is an organic compound with the formula C6H4SN(H)CO.


Proxel LV is a white solid, it is structurally related to isothiazole, and is part of a class of molecules called isothiazolinones.
Proxel LV is a broad spectrum biocide for the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi.
Proxel LV is a 20% aqueous dipropylene glycol solution of 1,2-benzisothiazolin-3-one.


Industrial biocide Proxel LV is present in can-end cements 1,2-Benzisothiazol-3(2H)-one belongs to the family of Benzothiazoles.
These are organic compounds containing a benzene fused to a thiazole ring (a five-member ring with four carbon atoms, one nitrogen atom and one sulfur atom).


Proxel LV is yellow Powder.
Proxel LV is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.


Proxel LV has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser.
Proxel LV is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
Proxel LV is the main industrial sterilization, anti-corrosion, anti-enzyme agent.


Proxel LV is the main industrial sterilization, anti-corrosion, anti-enzyme agent.
Proxel LV has outstanding inhibition of mold (fungi, bacteria), algae and other microorganisms in the role of the breeding of organic media, to solve the microbial breeding of organic products caused by mold, fermentation, deterioration, demulsification, and a series of questions.


Proxel LV is a simple isothiazolinone derivative.
Because of its good thermal stability (thermal decomposition temperature above 300 ℃), Proxel LV is beneficial to corrosion prevention.
Moreover, due to its advantages of high efficiency, low toxicity and easy degradation, Proxel LV has attracted extensive attention from experts in biology, medicine and chemistry.


Proxel LV is an aqueous/glycolic preparation of the biocidal active ingredient benzisothiazolinone, and has a broad spectrum of activity against bacteria, mold fungi and yeasts.
Proxel LV is supplied in pale yellow to yellow form and is especially suitable where there is no risk of discoloration.


Proxel LV has low volatility, good thermal stability, flexible use.
Proxel LV is a preparation solution of water and alcohol whose active ingredient is benzisothiazolinone, and has a broad-spectrum effect on bacteria, molds and yeasts.


Proxel LV is sustained release agent Diuron, aqueous dispersion of IPBC and propiconazole.
Proxel LV is in-can preservative based on benzisothiazolinone.
Proxel LV is Soluble in dichloromethane, dimethyl sulfoxide, methanol.


Proxel LV is an organic compound with the formula C6H4SN(H)CO.
Proxel LV is a combination Min. 19 % aqueous-glycolic solution of 1,2-Benzisothiazolin-3-one (BIT).
Proxel LV, known as Benzo[d]isothiazol-3-one, is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.


Proxel LV possesses low volatility and good thermal stability.
The shelf life of Proxel LV is 2 years.
A white solid, Proxel LV is structurally related to isothiazole, and is part of a class of molecules called isothiazolinones.


The good water solubility of Proxel LV enables simple and problem-free incorporation in the concentration ranges recommended for preservation.
Proxel LV is VOC-, AOX-, formaldehyde- & solvent-free, in-can preservative based on benzisothiazolinone.
The shelf life of Proxel LV is one year.


Proxel LV is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
Proxel LV is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.


Proxel LV is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria.
Data suggests Proxel LV has a low aqueous solubility and is rapidly broken down in the environment.


Proxel LV is aqueous-glycolic solution of 1,2-Benzisothiazolin-3-one (BIT).
Proxel LV has a broad spectrum of activity.
Proxel LV is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.
Proxel LV does not appear to have been extensively studied and hence little data is available.



USES and APPLICATIONS of PROXEL LV:
Proxel LV is effective in a wide range of industrial aqueous-based products such as synthetic polymer emulsions, emulsion paints, water-based adhesives, household products, printing inks, paper coating compositions, metal working fluids, agricultural pesticide dispersions, and aqueous mineral and pigment slurries.


Proxel LV is used industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
Proxel LV is used agriculture in pesticide formulations.


Proxel LV is used gas and oil drilling in muds and packer fluids preservation.
In paints, Proxel LV is commonly used alone or as a mixture with methylisothiazolinone.
Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides.


According to a study in Switzerland, 19% of the paints, varnishes and coatings contained Proxel LV in 2000.
The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%.
A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.


Home cleaning and other care products that are high in water are easily contaminated by microorganisms, so isothiazolinones are often used as a preservatives in these products because they are good at combatting a broad array of bacteria, fungi, and yeasts.
Proxel LV is used Laundry Care, Other Home Care, Dish Care, Fabric Care, Surface Care, and Auto Care, Polyurethane products, photographic lotion, papermaking, ink, leather, lubricating oil and other products.


Proxel LV is the main industrial sterilization, anti-corrosion and anti-enzyme agent.
Proxel LV is used as antimicrobial agent.
Proxel LV is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils.


Proxel LV exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.
Proxel LV has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.


Proxel LV is widely used as a preservative and antimicrobial.
Proxel LV has a microbicide and a fungicide mode of action.
Proxel LV is widely used as a preservative, for example in: Proxel LV is used emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions, home cleaning and car care products, laundry detergents, stain removers and fabric softeners.


Proxel LV is an irritant and also a skin sensitizer.
Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.


Proxel LV is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria.
Proxel LV is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.


Proxel LV is used as antimicrobial agent.
Proxel LV is specifically recommended for the preservation of polymer emulsions, paints and coatings, adhesives, and printing inks.
Therefore, developed countries will be widely used for Proxel LV latex products, water-soluble resin, paint (latex paint), acrylic acid, polymer.


Proxel LV is used as Linings, photographic lotions, paper, ink, leather, lubricants and other products.
Proxel LV is used as a preservative in manufacturing, metalworking fluids, pottery molding, plumbing, printing, and laboratory analysis.
Proxel LV is used as a preservative in vinyl gloves.


In many cases Proxel LV can be used as the only preservative.
Depending on the conditions and applications Proxel LV can be useful to combine it with other biocides to enhance the fungicidal efficacy.
Proxel LV is highly suitable for the preservation of a wide variety of aqueous products due to their good properties:
- Good stability at high pH (3-13)
- Good stability at high temperatures


Proxel LV is widely used in paint industry, cutting oils, water systems, cosmetics, household goods.
Most common applications include the preservation of polymer latexes and emulsion systems, water-based paints, coatings, adhesives, oil-in-water emulsions, textile spin-finish solutions, fountain solutions, and for bacterial control in the paper-making process.


Proxel LV is an effective preservative in most aqueous compositions.
For protection against bacterial contamination, a concentration of Proxel LV 20% ranging from 0.05 to 0.4% is generally adequate.
Proxel LV is a preservative that belongs to the group of isothiazolinones.


The preservative is added to aqueous products to inhibit the growth of bacteria and fungi.
Proxel LV is used removes contamination and cleans shoe soles before entry into cleanrooms, laboratories etc.
Proxel LV is used in personal care products and cosmetics.


Proxel LV acts as a disinfectant and can be used as a preservative.
Proxel LV is used as preservatives for latex emulsions, emulsion paints, metal-working fluids, etc.
Proxel LV is used in personal care products and cosmetics.


Proxel LV acts as a disinfectant and can be used as a preservative.
Proxel LV has been used in CSG, Hydraulic Fracturing Operations (Fracking) as Industrial biocide.
Cosmetic Uses of Proxel LV: antimicrobial agents


Proxel LV is the main industrial sterilization, anti-corrosion, and anti-enzyme agent.
Proxel LV has a prominent inhibition of mold, algae and other microorganisms in organic media.
Proxel LV can solve organic products caused by microbial growth.


A series of problems such as mildew, fermentation, deterioration, demulsification, and odor are widely used in sterilization, marine antifouling and other fields.
Proxel LV is widely used in latex products, water-soluble resins, coatings (latex paint), acrylic acid and polymers in developed countries.


Proxel LV is a biocide for use in the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi.
The recommended usage level of Proxel LV is 0.05-0.25% by weight in water-based adhesives.


-Film contains antibacterial Proxel LV produced biocides to reduce bacteria growth.
The mat is simply stuck to the floor near an entry or exit door by removing the rear protective backing layer.
Each tacky mat layer is then peeled off when dirty to reveal another new layer.
Each layer is coated with a high tack adhesive which removes dust or dirt contamination.


-Common sources and uses of Proxel LV:
*Paint and varnish
*Water-based colorless wood primers
*Basic cleaning agents
*Wallpaper adhesive, tissue adhesive
*Glue
*Polish
*Hardener's
*Coolant cutting fluid
*Impregnation
*Disinfection and cleaning agents
*Wet-wipes (wet wipes)
*Paint
*Cleaning products



TYPES OF Proxel LV:
*Preservatives for products during storage
*Slimicides
*Working or cutting fluid preservatives



PRODUCTION OF Proxel LV:
Proxel LV is prepared from dithiosalicylic acid after cleavage with thionyl chloride/sulfuryl chloride, reaction with ammonia and sodium hydroxide solution and then treatment with hydrochloric acid.



BENEFITS OF Proxel LV:
*Broad spectrum activity in high pH systems, controlling bacteria, fungi and yeasts.
*Stable in the presence of amines.
*Non specific mode of action, resulting in reduced microbial resistance potential.
*Ease of handling due to its liquid form and good compatibility in most aqueous compositions.
*Excellent performance with co-biocides like CMI/MI, bronopol or formaldehyde releasers, which allow performance enhancements and cost reduction.
*The active ingredient is non-volatile and has a comparatively high heat stability which allows the incorporation in fluids which are still hot.
*High purity active ingredient, made evident by its clear light colour.



WHERE IS Proxel LV FOUND?
Proxel LV is most frequently found in paints and industrial products
Proxel LV can be found in some types of vinyl gloves and neoprene gloves



ALTERNATIVE PARENTS OF PROXEL LV:
*Benzenoids
*Thiazoles
*Heteroaromatic compounds
*Azacyclic compounds
*Organopnictogen compounds
*Organooxygen compounds
*Organonitrogen compounds
*Hydrocarbon derivatives



SUBSTITUENTS OF PROXEL LV:
*1,2-benzothiazole
*Benzenoid
*Heteroaromatic compound
*Thiazole
*Azole
*Azacycle
*Organic nitrogen compound
*Organic oxygen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organooxygen compound
*Organonitrogen compound
*Aromatic heteropolycyclic compound



BASIC PROPERTIES AND CHARACTERISTICS OF PROXEL LV:
*broad-spectrum and fast-acting protection
*excellent efficiency at low concentration
*free of VOCs and solvents



PHYSICAL and CHEMICAL PROPERTIES of PROXEL LV:
Molecular form: C7H5NOS
Appearance: NA
Mol. Weight: 151.19
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications:NA
Melting Point: 154-158ºC
Boiling Point: 204.5ºC at 760 mmHg
Flash Point: 77.5ºC
Molecular Formula: C7H5NOS
Molecular Weight: 151.18600
Density: 1.367g/cm3
Molecular Weight: 151.19
XLogP3-AA: 1.3
Hydrogen Bond Donor Count: 1

Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 0
Exact Mass: 151.00918496
Monoisotopic Mass: 151.00918496
Topological Polar Surface Area: 54.4 Ų
Heavy Atom Count: 10
Formal Charge: 0
Complexity: 160
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1

Compound Is Canonicalized: Yes
Chemical formula: C7H5NOS
Molar mass: 151.18 g·mol−1
Appearance: white powder
Melting point: 158 °C (316 °F; 431 K)[1]
Solubility in water: 1 g/L
Appearance: white powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 154.00 to 158.00 °C. @ 0.00 mm Hg
Boiling Point: 204.00 to 205.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.183000 mmHg @ 25.00 °C. (est)
Flash Point: 172.00 °F. TCC ( 77.50 °C. ) (est)
logP (o/w): 1.953 (est)

Soluble in: water, 2.143e+004 mg/L @ 25 °C (est)
Melting point: 154-158 °C(lit.)
Boiling point: 360°C (rough estimate)
Density: 1.2170 (rough estimate)
vapor pressure: 0 Pa at 25℃
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in dichloromethane, dimethyl sulfoxide, methanol.
form: neat
pka: 10.19±0.20(Predicted)
color: White to Light yellow to Light orange
Water Solubility: 1.288g/L at 20℃
InChIKey: DMSMPAJRVJJAGA-UHFFFAOYSA-N
LogP: 0.7 at 20℃
Physical state: crystalline
Color: light yellow

Odor: No data available
Melting point/freezing point:
Melting point/range: 154 - 158 °C - lit.
Initial boiling point and boiling range: 328,7 °C at ca.1.013,25 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: 400 °C
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 1.153 g/l at 20 °C

Partition coefficient: n-octanol/water:
log Pow: 0,63 - 0,76 at 20 °C Bioaccumulation is not expected.
Vapor pressure: < 0,0001 hPa at 25 °C
Density: No data available
Relative density: 1,48 at 20 °C
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:
Surface tension 72,6 mN/m at 20 °C
Molecular Formula: C7H5NOS
Molar Mass: 151.18

Density: 1.367g/cm3
Melting Point: 154-158℃
Boling Point: 204.5°C at 760 mmHg
Flash Point: 77.5°C
Vapor Presure: 0.183mmHg at 25°C
Appearance: Yellow powder
Storage Condition: 2-8℃
Refractive Index: 1.66
MDL: MFCD00127753
Melting point: 154-158°C
Water Solubility: 3.21 g/L
logP: 1.24
logP: 1.36
logS: -1.7
pKa (Strongest Acidic): 9.48
pKa (Strongest Basic): -8.5

Physiological Charge: 0
Hydrogen Acceptor Count: 1
Hydrogen Donor Count: 1
Polar Surface Area: 29.1 Ų
Rotatable Bond Count: 0
Refractivity: 39.51 m³·mol⁻¹
Polarizability: 14.49 ų
Number of Rings: 2
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: No
Veber's Rule: Yes
MDDR-like Rule: No



FIRST AID MEASURES of PROXEL LV:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PROXEL LV:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of PROXEL LV:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of PROXEL LV:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
-Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PROXEL LV:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of PROXEL LV:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
no information available

Proxitane (also known as peroxyacetic acid, or PAA) is an organic compound with the formula CH3CO3H.
Proxitane is a weaker acid than the parent acetic acid, with a pKa of 8.2.


CAS Number: 79-21-0
EC Number: 201-186-8
Chemical formula: CH3CO3H


Proxitane, peracetic acid, peroxyacetic acid, estosteril, acetic peroxide, peroxoacetic acid, monoperacetic acid, osbon ac, acetyl hydroperoxide, proxitane 4002, desoxon 1, Ethaneperoxoic acid, Peroxyacetic acid, Acetic peroxide, Acetyl hydroperoxide,



Proxitane (also known as peroxyacetic acid, or PAA) is an organic compound with the formula CH3CO3H.
Proxitane is a colorless liquid with a characteristic acrid odor reminiscent of acetic acid.
Proxitane is formulated with very effective corrosion inhibitors, it is safe for most common endoscope materials.


Proxitane is non-corrosive to stainless steel plant equipment under both hot and cold conditions.
Efficacy may be reduced by grease, fat, proteins and other organic matter.
Proxitane works best at a pH <7; hence, rinse equipment of alkaline detergents.


Proxitane is amongst the most powerful biocides known to man.
Proxitane is effective against a wide spectrum of microbiological contaminations including aerobic and anaerobic bacteria and their spores, yeasts, moulds, fungi and their spores, and viruses.


Proxitane is extremely rapid in its action at ambient temperatures.
Proxitane is “low foaming” and ideal for use in “Clean in Place” systems.
Proxitane is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.


Proxitane (also known as peroxyacetic acid, or PAA) is an organic compound with the formula CH3CO3H.
Proxitane is a colorless liquid with a characteristic acrid odor reminiscent of acetic acid.
Proxitane is a weaker acid than the parent acetic acid, with a pKa of 8.2.
Proxitane does not fix proteins, eliminates biofilm and is effective even in the presence of organic materials.



USES and APPLICATIONS of PROXITANE:
Other release to the environment of Proxitane is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).


Proxitane is used in the following products: washing & cleaning products, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products), paper chemicals and dyes and water treatment chemicals.
Release to the environment of Proxitane can occur from industrial use: formulation of mixtures.


Proxitane is used in the following products: washing & cleaning products, paper chemicals and dyes, textile treatment products and dyes and perfumes and fragrances.
Proxitane has an industrial use resulting in manufacture of another substance (use of intermediates).


Proxitane is used in the following areas: scientific research and development and health services.
Proxitane is used for the manufacture of: textile, leather or fur, chemicals, pulp, paper and paper products and food products.
Release to the environment of Proxitane can occur from industrial use: as processing aid and in processing aids at industrial sites.


Release to the environment of Proxitane can occur from industrial use: manufacturing of the substance.
The United States Environmental Protection Agency first registered Proxitane as an antimicrobial in 1986 for indoor use on hard surfaces.
Use sites include agricultural premises, food establishments, medical facilities, and home bathrooms.


Proxitane is also registered for use in dairy and cheese processing plants, on food processing equipment, and in pasteurizers in breweries, wineries, and beverage plants.
Proxitane is used in the following areas: health services and scientific research and development.


Proxitane is used for the manufacture of: textile, leather or fur.
Proxitane is also applied for the disinfection of medical supplies, to prevent biofilm formation in pulp industries, and as a water purifier and disinfectant.


Proxitane can be used as a cooling tower water disinfectant, where it prevents biofilm formation and effectively controls Legionella bacteria.
A trade name for Proxitane as an antimicrobial is Nu-Cidex.
In the European Union, Proxitane was reported by the EFSA after submission in 2013 by the US Department of Agriculture.


Decontamination kits for cleaning fentanyl analogues from surfaces (as used by many police forces, amongst others) often contain solid peracetyl borate, which mixes with water to produce Proxitane.
Computer searching of the literature, both applied and academic, has not revealed a reference to the induction of mutagenesis, leading to the development of resistant species, by Proxitane.


Proxitane is used as a biocide to sanitize degreased and precleaned processing, transfer and storage plant in stainless steel or glass.
Proxitane is used in the following products: washing & cleaning products.
Other release to the environment of Proxitane is likely to occur from: indoor use as reactive substance.


Proxitane is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products) and laboratory chemicals.
Proxitane can also be used on floors, walls and in the atmosphere.
In food and beverage processing and production Proxitane finds application in the regular cleaning cycle of syrup make up plant, treated water carbonators, fruit crushing, juice concentrators and reconstitutors, food or condiment cookers and processors, transfer pipes/pumps, bottling/packaging/canning machines.


In breweries and wineries Proxitane finds application in the fermentation/ brew houses, the clarification/ filtration plant and tank farms/ bottling cellars during regular plant cleaning.
Proxitane is also used as a rapid high level disinfectant in the farming industry to protect animals from diseases.



Additionally, experts use Proxitane in the medical sector to sterilize equipment, pharmaceuticals and instruments, with the ultimate goal of improving patient health and wellbeing.
Proxitane may also be used on floors, walls and airborne.


Proxitane is used widely in food and beverage processing and production, breweries and wineries.
Proxitane is a non-rinse, anti-microbial CIP sanitiser.
Proxitane is used as a biocide to sanitise pre-cleaned processing equipment, transfer and storage plant, made from stainless steel or glass.


Proxitane is low-foaming and ideal for use in clean-in-place (CIP) systems.
Proxitane, the active compound in Proxitane, is among the most powerful known biocides.
Proxitane is effective against a wide spectrum of microbiological contaminations including aerobic and anaerobic bacteria and their spores; yeasts, moulds, fungi and their spores; and viruses.


Proxitane is extremely rapid in its action at ambient temperatures.
In food and beverage processing and production, use Proxitane in the regular cleaning cycle of syrup make-up plant, treated water carbonators, fruit crushing, juice concentrators and reconstitutors, food or condiment cookers and processors, transfer pipes and pumps, bottling, packaging and canning machines.


In breweries and wineries, use Proxitane in regular plant cleaning in fermentation and brewhouses, clarification and filtration plant, tank farms and bottling cellars.
Proxitane is formulated to be used on pre-cleaned surfaces that contain no detergents or surfactants.


The products performance will be dramatically reduced if soils are present on the surface such as fats, oil, starches or vegetable matter.
Proxitane sanitation is most efficient at pH’s below 7.
Proxitane is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.


Proxitane is sanitiser which is recommended for use on pre-cleaned surfaces such as equipment, pipelines, tanks, vats, filters, evaporators, pasteurises, and aseptic equipment in dairies, brewers, wineries, beverage and food processing plants, egg processing/packing equipment surfaces and eating establishments.


Proxitane is approved for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, veterinary hygiene, food and animals feeds, drinking water, product preservation, preservation for liquid systems, controlling slimes.
Proxitane may be introduced continuously or intermittently depending upon needs of the end user.


Proxitane is a low foaming, clear, colourless liquid comprising an equilibrium mixture of peracetic acid, hydrogen peroxide, acetic acid and water.
Proxitane is used as a biocide to sanitise pre-cleaned surfaces in the food industry.
Proxitane is specialized for quick disinfection, environmental sanitation or in the final stages of cleaning equipment pipes and containers in breweries, milk and water factories beverage and other food processing industries.


So the chemical Proxitane is used instead of BKC , Formalin (formol) for disinfecting shrimp ponds.
The chemical Proxitane 15:23 can also cut toxic algae in ponds, decompose excess organic matter, and provide oxygen to the shrimp pond water environment.
The pH of a 1: 100 dilution of this product is about 3.0 and a 1: 500 dilution about ph 4.0.


Temperature plays a factor in effectiveness of Proxitane, for example at a temperature of 15°C and a pH value of 7, five times more peractetic acid is required to effectively deactivate pathogens than at a pH value of 7 and a temperature of 35°C.


Proxitane is effective against a wide spectrum of
microbiological contaminations: bacteria, yeasts, moulds, fungi, viruses.
Sanitises degreased and precleaned CIP stainless steel or glass equipment.


Proxitane may also be used on floors, walls and airborne.
Proxitane is used widely in food and beverage processing and production, breweries and wineries.
Proxitane is a non-rinse, anti-microbial CIP sanitiser.


Proxitane is used as a biocide to sanitise pre-cleaned processing equipment, transfer and storage plant, made from stainless steel or glass.
A final water rinse is not necessary.
Proxitane is compatible with most post harvest fungicides.


Proxitane is non-corrosive in its diluted form against stainless steel and aluminium surfaces.
If the product is to be used on other surfaces, Proxitane is recommended that you apply product to a smaller test area
to determine compatibility before proceeding with its use.


Proxitane may be fed to either the system water or the make-up water at an area of good mixing to promote rapid dispersion.
Proxitane can be continuously sprayed, using coarse spray, or submerged using solution containing no more than 40 ppm residual Peroxyacetic Acid.
Proxitane chemical is used to quickly disinfect food contact surfaces, especially in the beer, beverage, milk processing, canning, bottling of food and vegetable industries, and seafood processing. seafood, meat, sugar, cakes , chocolate and candy.


Proxitane is very effective in disinfecting all types of microorganisms, even in cold water conditions.
Proxitane component in proxitane helps the product to be effective in quick pasteurization and the presence of hydrogen peroxide helps the product adapt to soaking or shampooing .


Proxitane is an excellent food grade sanitiser and also has uses as laundry bleach.
Each application may require a specific dosage rate and like all oxidising biocides, soil loadings can affect required application rate.
Proxitane is biocidal at between 100 and 200 mg/L as Peroxy acetic (Peracetic) acid levels.


Testing strips to determine in use concentration of Proxitane are available from Castle Chemicals.
Proxitane is low-foaming and ideal for use in clean-in-place (CIP) systems.
Proxitane, the active compound in Proxitane, is among the most powerful known biocides.


Proxitane is effective against a wide spectrum of
microbiological contaminations including aerobic and anaerobic bacteria and their spores; yeasts, moulds, fungi and their spores; and viruses.
Proxitane is extremely rapid in its action at ambient temperatures.


In food and beverage processing and production, use Proxitane in the regular cleaning cycle of syrup make-up plant, treated water carbonators, fruit crushing, juice concentrators and reconstitutors, food or condiment cookers and processors, transfer pipes and pumps, bottling, packaging and canning machines.


In breweries and wineries, use Proxitane in regular plant cleaning in fermentation and brewhouses, clarification and filtration plant, tank farms and bottling cellars.
Proxitane has a high oxidation potential and is very reactive.


Proxitane exhibits excellent bactericidal and fungicidal activity against a wide range of microorganisms in cold and warm water.
Also more effective than chlorine, chlorine dioxide and quaternary products for sanitising food contact surfaces.
Proxitane helps to control spoilage or decay-causing bacteria and fungi in water that contacts raw, unprocessed fruits and vegetables.


As Proxitane does not contain surfactants it is ideal for use in ‘clean in place’ systems as part of a no water rinse regimen when systems can be flushed with finished product (to drain) before normal production resumes.”
Dairies & dairy farms uses of Proxitane: When used in dairy farms, after the use of Proxitane surfaces must be drained and thoroughly rinsed with water prior to the next milking.


Proxitane is a high level disinfectant especially formulated for the cold sterilization of thermosensitive instruments and endoscopes.
It is based on a synergy of Proxitane and hydrogen peroxide.
Proxitane combines a broad spectrum of antimicrobial activity, rapid contact times and an enhanced material compatibility.


Proxitane gastroscopes, duodenoscopes, naso-laryngo-pharyngoscopes, laparoscopes, etc.), surgical instruments, anesthetic and heat- sensitive medical devices.
In addition, Proxitane is also a good disinfectant for the environment because it leaves no residue when used.



HOW TO PRESERVE AND USE PROXITANE:
The concentration of Proxitane can easily decrease when allowed to evaporate in the air.
Therefore, we only dilute Proxitane when used in sufficient doses.
Proxitane must be stored in a cool place, away from direct sunlight.



A VERSATILE PROXITANE:
In the food industry, Proxitane is used in Cleaning in Place and Food Contact Sanitisation processes for safe, rapid microbial control.
Notably, certain food products, such as meat, poultry, fruit, vegetables and eggs, require direct protection as they can carry harmful microbes and be prone to spoilage. In addition to microbial protection, Proxitane effectively boosts food safety by reducing the loss of goods due to fungi, viruses, algae and bacteria and enhances product quality throughout the useful shelf life and, in some cases, extends the shelf life itself.



PROPERTIES OF PROXITANE:
*Ready-to-use mixed solution
*Effective even with the presence of proteins
*Compatible with most common sensible materials
*Compatible with heat-sensitive instruments
*Rapid action: full spectrum in 5 min.
*Stability of the ready-to-use solution: 15 days
*Easy checking of PAA concentration with test strips
*No aldehydes, safe for the user
*Decomposes in water and oxygen



ODOR OF PROXITANE:
At diluted concentrations, Proxitane is almost odorless.
However, the chemical Proxitane in concentrated form has a very strong and characteristic odor that helps users immediately distinguish it from other chemicals.



PROXITANE CHEMICAL WILL DEPEND ON FACTORS:
Concentration, temperature and types of microorganisms that need to be destroyed.
However, usually we use Proxitane at a concentration of 0.05%–0.3% (mainly 0.2-0.5%).

The temperature for using Proxitane is in the range of 5–20 ºC .
If Proxitane is around 50ºC, the sterilization efficiency is higher and the sterilization time is shorter.
Do not use Proxitane at temperatures higher than 50ºC.

Proxitane at high concentrations can be stored for reuse, however, provided that they are not too dirty and additional proxitane chemicals must be added to ensure concentration.
Because Proxitane at high concentrations has a very strong odor, when using, mixing solutions, transporting.



PRODUCTION OF PROXITANE:
Peracetic acid is produced industrially by the autoxidation of acetaldehyde:
O2 + CH3CHO → CH3CO3H
In the presence of a strong acid catalyst, such as sulfuric acid, acetic acid and hydrogen peroxide produce Proxitane:

H2O2 + CH3CO2H ⇌ CH3CO3H + H2O
However, in concentrations (3-6%) of vinegar and hydrogen peroxide marketed for household use, mixing without a strong acid catalyst will not form Proxitane.
As an alternative, acetyl chloride and acetic anhydride can be used to generate a solution of the acid with lower water content.

Proxitane is generated in situ by some laundry detergents.
This is achieved by the action of bleach activators, such as tetraacetylethylenediamine and sodium nonanoyloxybenzenesulfonate, upon hydrogen peroxide formed from sodium percarbonate in water.
The Proxitane is a more effective bleaching agent than hydrogen peroxide itself.

Proxitane is also formed naturally in the environment through a series of photochemical reactions involving formaldehyde and photo-oxidant radicals.
Proxitane is always sold in solution as a mixture with acetic acid and hydrogen peroxide to maintain its stability.
The concentration of Proxitane as the active ingredient can vary.



EPOXIDATION, PROXITANE:
Although less active than more acidic peracids (e.g., m-CPBA), Proxitane in various forms is used for the epoxidation of various alkenes (Prilezhaev reaction).
Useful applications are for unsaturated fats, synthetic and natural rubbers, and some natural products such as pinene.

A variety of factors affect the amount of free acid or sulfuric acid (used to prepare the peracid in the first place).
Proxitane is a highly effective biocide and oxidizing agent, rapidly destroys microorganisms such as bacteria, fungi and viruses and kills pathogens.

While it is extremely performant, Proxitane is chlorine free and breaks down quickly into naturally occurring substances (water, oxygen and carbon dioxide) ౼ making it a sustainable, environmentally friendly choice.
For these reasons, Proxitane is the ideal disinfectant across a number of different industries, namely medical, food and drink, animal biosecurity and industrial laundry.



PHYSICAL and CHEMICAL PROPERTIES of PROXITANE:
Chemical formula: CH3CO3H
Molar mass: 76.05 g/mol
Appearance :Colorless liquid
Density: 1.0375 g/mL
Melting point: 0 °C (32 °F; 273 K)
Boiling point: 105 °C (221 °F; 378 K) 25 C @ (1.6 kPa)
Acidity (pKa): 8.2
Refractive index (nD): 1.3974 (589 nm, 20 °C)
Viscosity: 3.280 cP
Physical state: liquid
Color: No data available
Odor: No data available

Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 56 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 26,66 hPa at 25 °C

Density: 1,13 g/cm3
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available
Density: 1.15g/mL at 20°C
Linear Formula: CH3CO3H
Beilstein: 1098464
Formula Weight: 76.05g/mol
Grade: purum p.a.
Chemical Name or Material: Peracetic acid solution



FIRST AID MEASURES of PROXITANE:
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
Call a physician immediately.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Call a physician immediately.
Do not attempt to neutralise.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PROXITANE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of PROXITANE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of PROXITANE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 480 min
Splash contact:
Material: Nature latex/chloroprene
Minimum layer thickness: 0,6 mm
Break through time: 30 min
*Body Protection:
Flame retardant antistatic protective clothing.
*Respiratory protection:
Recommended Filter type: Filter type ABEK
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PROXITANE:
-Precautions for safe handling:
*Advice on safe handling:
Take precautionary measures against static discharge.
*Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
*Storage stability:
Recommended storage temperature: 2 - 8 °C
Light sensitive.



STABILITY and REACTIVITY of PROXITANE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Proxitane Peracetic Acid (also known as peroxyacetic acid, or PAA) is an organic compound with the formula CH3CO3H.
Proxitane Peracetic Acid is a colorless liquid with a characteristic acrid odor reminiscent of acetic acid.


CAS Number: 79-21-0
EC Number: 201-186-8
Chemical formula: CH3CO3H



Ethaneperoxoic acid, Peroxyacetic acid, Acetic peroxide, Acetyl hydroperoxide, Proxitane, peracetic acid, peroxyacetic acid, estosteril, acetic peroxide, peroxoacetic acid, monoperacetic acid, osbon ac, acetyl hydroperoxide, proxitane 4002, desoxon 1,



Proxitane Peracetic Acid is amongst the most powerful biocides known to man.
Proxitane Peracetic Acid is effective against a wide spectrum of microbiological contaminations including aerobic and anaerobic bacteria and their spores, yeasts, moulds, fungi and their spores, and viruses.


Proxitane Peracetic Acid is extremely rapid in its action at ambient temperatures.
Proxitane Peracetic Acid is “low foaming” and ideal for use in “Clean in Place” systems.
It is a water clear, colourless liquid comprising an equilibrium mixture of Proxitane Peracetic Acid, water, acetic acid and hydrogen peroxide.


Proxitane Peracetic Acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Proxitane Peracetic Acid (also known as peroxyacetic acid, or PAA) is an organic compound with the formula CH3CO3H.


Proxitane Peracetic Acid is a colorless liquid with a characteristic acrid odor reminiscent of acetic acid.
Proxitane Peracetic Acid is a weaker acid than the parent acetic acid, with a pKa of 8.2.
Proxitane Peracetic Acid does not fix proteins, eliminates biofilm and is effective even in the presence of organic materials.


Proxitane Peracetic Acid is formulated with very effective corrosion inhibitors, it is safe for most common endoscope materials.
Proxitane Peracetic Acid is non-corrosive to stainless steel plant equipment under both hot and cold conditions.
Efficacy may be reduced by grease, fat, proteins and other organic matter.
Proxitane Peracetic Acid works best at a pH <7; hence, rinse equipment of alkaline detergents.



USES and APPLICATIONS of PROXITANE PERACETIC ACID:
Proxitane Peracetic Acid is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Proxitane Peracetic Acid is approved for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, veterinary hygiene, food and animals feeds, drinking water, product preservation, preservation for liquid systems, controlling slimes.


Proxitane Peracetic Acid is used in the following products: washing & cleaning products.
Other release to the environment of Proxitane Peracetic Acid is likely to occur from: indoor use as reactive substance.
Proxitane Peracetic Acid is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products) and laboratory chemicals.


Other release to the environment of Proxitane Peracetic Acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).


Proxitane Peracetic Acid is used in the following products: washing & cleaning products, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products), paper chemicals and dyes and water treatment chemicals.
Release to the environment of Proxitane Peracetic Acid can occur from industrial use: formulation of mixtures.


Proxitane Peracetic Acid is used in the following products: washing & cleaning products, paper chemicals and dyes, textile treatment products and dyes and perfumes and fragrances.
Proxitane Peracetic Acid has an industrial use resulting in manufacture of another substance (use of intermediates).


Proxitane Peracetic Acid is used in the following areas: scientific research and development and health services.
Proxitane Peracetic Acid is used for the manufacture of: textile, leather or fur, chemicals, pulp, paper and paper products and food products.
Release to the environment of Proxitane Peracetic Acid can occur from industrial use: as processing aid and in processing aids at industrial sites.


Release to the environment of Proxitane Peracetic Acid can occur from industrial use: manufacturing of the substance.
The United States Environmental Protection Agency first registered Proxitane Peracetic Acid as an antimicrobial in 1986 for indoor use on hard surfaces.
Use sites include agricultural premises, food establishments, medical facilities, and home bathrooms.


Proxitane Peracetic Acid is also registered for use in dairy and cheese processing plants, on food processing equipment, and in pasteurizers in breweries, wineries, and beverage plants.
Proxitane Peracetic Acid is used in the following areas: health services and scientific research and development.


Proxitane Peracetic Acid is used for the manufacture of: textile, leather or fur.
Proxitane Peracetic Acid is also applied for the disinfection of medical supplies, to prevent biofilm formation in pulp industries, and as a water purifier and disinfectant.


Proxitane Peracetic Acid can be used as a cooling tower water disinfectant, where it prevents biofilm formation and effectively controls Legionella bacteria.
A trade name for Proxitane Peracetic Acid as an antimicrobial is Nu-Cidex.


In the European Union, Proxitane Peracetic Acid was reported by the EFSA after submission in 2013 by the US Department of Agriculture.
Decontamination kits for cleaning fentanyl analogues from surfaces (as used by many police forces, amongst others) often contain solid peracetyl borate, which mixes with water to produce Proxitane Peracetic Acid.


Computer searching of the literature, both applied and academic, has not revealed a reference to the induction of mutagenesis, leading to the development of resistant species, by Proxitane Peracetic Acid.
Proxitane Peracetic Acid is used as a biocide to sanitize degreased and precleaned processing, transfer and storage plant in stainless steel or glass.


Proxitane Peracetic Acid can also be used on floors, walls and in the atmosphere.
In food and beverage processing and production Proxitane Peracetic Acid finds application in the regular cleaning cycle of syrup make up plant, treated water carbonators, fruit crushing, juice concentrators and reconstitutors, food or condiment cookers and processors, transfer pipes/pumps, bottling/packaging/canning machines.


In breweries and wineries Proxitane Peracetic Acid finds application in the fermentation/ brew houses, the clarification/ filtration plant and tank farms/ bottling cellars during regular plant cleaning.
Proxitane Peracetic Acid is also used as a rapid high level disinfectant in the farming industry to protect animals from diseases.


Additionally, experts use Proxitane Peracetic Acid in the medical sector to sterilize equipment, pharmaceuticals and instruments, with the ultimate goal of improving patient health and wellbeing.
Proxitane Peracetic Acid may also be used on floors, walls and airborne.


Proxitane Peracetic Acid is used widely in food and beverage processing and production, breweries and wineries.
Proxitane Peracetic Acid is a non-rinse, anti-microbial CIP sanitiser.
Proxitane Peracetic Acid is used as a biocide to sanitise pre-cleaned processing equipment, transfer and storage plant, made from stainless steel or glass.


Proxitane Peracetic Acid is low-foaming and ideal for use in clean-in-place (CIP) systems.
Proxitane Peracetic Acid, the active compound in Proxitane, is among the most powerful known biocides.
Proxitane Peracetic Acid is effective against a wide spectrum of microbiological contaminations including aerobic and anaerobic bacteria and their spores; yeasts, moulds, fungi and their spores; and viruses.


Proxitane Peracetic Acid is extremely rapid in its action at ambient temperatures.
In food and beverage processing and production, use Proxitane Peracetic Acid in the regular cleaning cycle of syrup make-up plant, treated water carbonators, fruit crushing, juice concentrators and reconstitutors, food or condiment cookers and processors, transfer pipes and pumps, bottling, packaging and canning machines.


In breweries and wineries, use Proxitane Peracetic Acid in regular plant cleaning in fermentation and brewhouses, clarification and filtration plant, tank farms and bottling cellars.
Proxitane Peracetic Acid is formulated to be used on pre-cleaned surfaces that contain no detergents or surfactants.


The products performance will be dramatically reduced if soils are present on the surface such as fats, oil, starches or vegetable matter.
Proxitane Peracetic Acid sanitation is most efficient at pH’s below 7.
The pH of a 1: 100 dilution of this product is about 3.0 and a 1: 500 dilution about ph 4.0.


Temperature plays a factor in effectiveness of Proxitane Peracetic Acid, for example at a temperature of 15°C and a pH value of 7, five times more peractetic acid is required to effectively deactivate pathogens than at a pH value of 7 and a temperature of 35°C.
Proxitane Peracetic Acid is effective against a wide spectrum of
microbiological contaminations: bacteria, yeasts, moulds, fungi, viruses. Sanitises degreased and precleaned CIP stainless steel or glass equipment.


Proxitane Peracetic Acid may also be used on floors, walls and airborne.
Proxitane Peracetic Acid is used widely in food and beverage processing and production, breweries and wineries.
Proxitane Peracetic Acid is a non-rinse, anti-microbial CIP sanitiser.


Proxitane Peracetic Acid is used as a biocide to sanitise pre-cleaned processing equipment, transfer and storage plant, made from stainless steel or glass.
Proxitane Peracetic Acid is low-foaming and ideal for use in clean-in-place (CIP) systems.
Proxitane Peracetic Acid, the active compound in Proxitane, is among the most powerful known biocides.


Proxitane Peracetic Acid is effective against a wide spectrum of
microbiological contaminations including aerobic and anaerobic bacteria and their spores; yeasts, moulds, fungi and their spores; and viruses.
Proxitane Peracetic Acid is extremely rapid in its action at ambient temperatures.


In food and beverage processing and production, use Proxitane Peracetic Acid in the regular cleaning cycle of syrup make-up
plant, treated water carbonators, fruit crushing, juice concentrators and reconstitutors, food or condiment cookers and processors, transfer pipes and pumps, bottling, packaging and canning machines.


In breweries and wineries, use Proxitane Peracetic Acid in regular plant cleaning in fermentation and brewhouses, clarification
and filtration plant, tank farms and bottling cellars.
Proxitane Peracetic Acid has a high oxidation potential and is very reactive.


Proxitane Peracetic Acid exhibits excellent bactericidal and
fungicidal activity against a wide range of microorganisms in cold and warm water.
Also more effective than chlorine, chlorine dioxide and quaternary products for sanitising food contact surfaces.


Proxitane Peracetic Acid helps to control spoilage or decay-causing bacteria and fungi in water that contacts raw, unprocessed fruits and vegetables.
Proxitane Peracetic Acid can be continuously sprayed, using coarse spray, or submerged using solution containing no more than 40 ppm residual Peroxyacetic Acid.


Proxitane Peracetic Acid is sanitiser which is recommended for use on pre-cleaned surfaces such as equipment, pipelines, tanks, vats, filters, evaporators, pasteurises, and aseptic equipment in dairies, brewers, wineries, beverage and food processing plants, egg processing/packing equipment surfaces and eating establishments.


A final water rinse is not necessary.
Proxitane Peracetic Acid is compatible with most post harvest fungicides.
Proxitane Peracetic Acid is non-corrosive in its diluted form against stainless steel and aluminium surfaces.


If the product is to be used on other surfaces, Proxitane Peracetic Acid is recommended that you apply product to a smaller test area
to determine compatibility before proceeding with its use.
Proxitane Peracetic Acid may be fed to either the system water or the make-up water at an area of good mixing to promote rapid dispersion.


Proxitane Peracetic Acid may be introduced continuously or intermittently depending upon needs of the end user.
Proxitane Peracetic Acid is a low foaming, clear, colourless liquid comprising an equilibrium mixture of peracetic acid, hydrogen peroxide, acetic acid and water.


Proxitane Peracetic Acid is used as a biocide to sanitise pre-cleaned surfaces in the food industry.
Proxitane Peracetic Acid is specialized for quick disinfection, environmental sanitation or in the final stages of cleaning equipment pipes and containers in breweries, milk and water factories beverage and other food processing industries.


So the chemical Proxitane Peracetic Acid is used instead of BKC , Formalin (formol) for disinfecting shrimp ponds.
The chemical Proxitane Peracetic Acid 15:23 can also cut toxic algae in ponds, decompose excess organic matter, and provide oxygen to the shrimp pond water environment.


Proxitane Peracetic Acid chemical is used to quickly disinfect food contact surfaces, especially in the beer, beverage, milk processing, canning, bottling of food and vegetable industries, and seafood processing. seafood, meat, sugar, cakes , chocolate and candy.
Proxitane Peracetic Acid is very effective in disinfecting all types of microorganisms, even in cold water conditions.


Proxitane Peracetic Acid component in proxitane helps the product to be effective in quick pasteurization and the presence of hydrogen peroxide helps the product adapt to soaking or shampooing .
Proxitane Peracetic Acid is an excellent food grade sanitiser and also has uses as laundry bleach.


Each application may require a specific dosage rate and like all oxidising biocides, soil loadings can affect required application rate.
Proxitane Peracetic Acid is biocidal at between 100 and 200 mg/L as Peroxy acetic (Peracetic) acid levels.


As Proxitane Peracetic Acid does not contain surfactants it is ideal for use in ‘clean in place’ systems as part of a no water rinse regimen when systems can be flushed with finished product (to drain) before normal production resumes.”
Dairies & dairy farms uses of Proxitane Peracetic Acid: When used in dairy farms, after the use of Proxitane Peracetic Acid surfaces must be drained and thoroughly rinsed with water prior to the next milking.


Proxitane Peracetic Acid is a high level disinfectant especially formulated for the cold sterilization of thermosensitive instruments and endoscopes.
It is based on a synergy of Proxitane Peracetic Acid and hydrogen peroxide.
Proxitane Peracetic Acid combines a broad spectrum of antimicrobial activity, rapid contact times and an enhanced material compatibility.


Proxitane Peracetic Acid gastroscopes, duodenoscopes, naso-laryngo-pharyngoscopes, laparoscopes, etc.), surgical instruments, anesthetic and heat- sensitive medical devices.
In addition, Proxitane Peracetic Acid is also a good disinfectant for the environment because it leaves no residue when used.



HOW TO PRESERVE AND USE PROXITANE PERACETIC ACID:
The concentration of Proxitane Peracetic Acid can easily decrease when allowed to evaporate in the air.
Therefore, we only dilute Proxitane Peracetic Acid when used in sufficient doses.
Proxitane Peracetic Acid must be stored in a cool place, away from direct sunlight.



A VERSATILE PROXITANE PERACETIC ACID:
In the food industry, Proxitane Peracetic Acid is used in Cleaning in Place and Food Contact Sanitisation processes for safe, rapid microbial control.
Notably, certain food products, such as meat, poultry, fruit, vegetables and eggs, require direct protection as they can carry harmful microbes and be prone to spoilage. In addition to microbial protection, Proxitane Peracetic Acid effectively boosts food safety by reducing the loss of goods due to fungi, viruses, algae and bacteria and enhances product quality throughout the useful shelf life and, in some cases, extends the shelf life itself.



PRODUCTION OF PROXITANE PERACETIC ACID:
Peracetic acid is produced industrially by the autoxidation of acetaldehyde:
O2 + CH3CHO → CH3CO3H
In the presence of a strong acid catalyst, such as sulfuric acid, acetic acid and hydrogen peroxide produce Proxitane Peracetic Acid:

H2O2 + CH3CO2H ⇌ CH3CO3H + H2O
However, in concentrations (3-6%) of vinegar and hydrogen peroxide marketed for household use, mixing without a strong acid catalyst will not form Proxitane Peracetic Acid.
As an alternative, acetyl chloride and acetic anhydride can be used to generate a solution of the acid with lower water content.

Proxitane Peracetic Acid is generated in situ by some laundry detergents.
This is achieved by the action of bleach activators, such as tetraacetylethylenediamine and sodium nonanoyloxybenzenesulfonate, upon hydrogen peroxide formed from sodium percarbonate in water.
The Proxitane Peracetic Acid is a more effective bleaching agent than hydrogen peroxide itself.

Proxitane Peracetic Acid is also formed naturally in the environment through a series of photochemical reactions involving formaldehyde and photo-oxidant radicals.
Proxitane Peracetic Acid is always sold in solution as a mixture with acetic acid and hydrogen peroxide to maintain its stability.
The concentration of Proxitane Peracetic Acid as the active ingredient can vary.



PROPERTIES OF PROXITANE PERACETIC ACID:
*Ready-to-use mixed solution
*Effective even with the presence of proteins
*Compatible with most common sensible materials
*Compatible with heat-sensitive instruments
*Rapid action: full spectrum in 5 min.
*Stability of the ready-to-use solution: 15 days
*Easy checking of PAA concentration with test strips
*No aldehydes, safe for the user
*Decomposes in water and oxygen



ODOR OF PROXITANE PERACETIC ACID:
At diluted concentrations, Proxitane Peracetic Acid is almost odorless.
However, the chemical Proxitane Peracetic Acid in concentrated form has a very strong and characteristic odor that helps users immediately distinguish it from other chemicals.



PROXITANE PERACETIC ACID CHEMICAL WILL DEPEND ON FACTORS:
Concentration, temperature and types of microorganisms that need to be destroyed.
However, usually we use Proxitane Peracetic Acid at a concentration of 0.05%–0.3% (mainly 0.2-0.5%).

The temperature for using Proxitane Peracetic Acid is in the range of 5–20 ºC .
If Proxitane Peracetic Acid is around 50ºC, the sterilization efficiency is higher and the sterilization time is shorter.
Do not use Proxitane Peracetic Acid at temperatures higher than 50ºC.

Proxitane Peracetic Acid at high concentrations can be stored for reuse, however, provided that they are not too dirty and additional proxitane chemicals must be added to ensure concentration.
Because Proxitane Peracetic Acid at high concentrations has a very strong odor, when using, mixing solutions, transporting.



EPOXIDATION, PROXITANE PERACETIC ACID:
Although less active than more acidic peracids (e.g., m-CPBA), Proxitane Peracetic Acid in various forms is used for the epoxidation of various alkenes (Prilezhaev reaction).
Useful applications are for unsaturated fats, synthetic and natural rubbers, and some natural products such as pinene.

A variety of factors affect the amount of free acid or sulfuric acid (used to prepare the peracid in the first place).
Proxitane Peracetic Acid is a highly effective biocide and oxidizing agent, rapidly destroys microorganisms such as bacteria, fungi and viruses and kills pathogens.

While it is extremely performant, Proxitane Peracetic Acid is chlorine free and breaks down quickly into naturally occurring substances (water, oxygen and carbon dioxide) ౼ making it a sustainable, environmentally friendly choice.
For these reasons, Proxitane Peracetic Acid is the ideal disinfectant across a number of different industries, namely medical, food and drink, animal biosecurity and industrial laundry.



PHYSICAL and CHEMICAL PROPERTIES of PROXITANE PERACETIC ACID:
Chemical formula: CH3CO3H
Molar mass: 76.05 g/mol
Appearance :Colorless liquid
Density: 1.0375 g/mL
Melting point: 0 °C (32 °F; 273 K)
Boiling point: 105 °C (221 °F; 378 K) 25 C @ (1.6 kPa)
Acidity (pKa): 8.2
Refractive index (nD): 1.3974 (589 nm, 20 °C)
Viscosity: 3.280 cP
Physical state: liquid
Color: No data available
Odor: No data available

Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 56 °C - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 26,66 hPa at 25 °C

Density: 1,13 g/cm3
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available
Density: 1.15g/mL at 20°C
Linear Formula: CH3CO3H
Beilstein: 1098464
Formula Weight: 76.05g/mol
Grade: purum p.a.
Chemical Name or Material: Peracetic acid solution



FIRST AID MEASURES of PROXITANE PERACETIC ACID:
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
Call a physician immediately.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Call a physician immediately.
Do not attempt to neutralise.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PROXITANE PERACETIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of PROXITANE PERACETIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of PROXITANE PERACETIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 480 min
Splash contact:
Material: Nature latex/chloroprene
Minimum layer thickness: 0,6 mm
Break through time: 30 min
*Body Protection:
Flame retardant antistatic protective clothing.
*Respiratory protection:
Recommended Filter type: Filter type ABEK
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PROXITANE PERACETIC ACID:
-Precautions for safe handling:
*Advice on safe handling:
Take precautionary measures against static discharge.
*Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
*Storage stability:
Recommended storage temperature: 2 - 8 °C
Light sensitive.



STABILITY and REACTIVITY of PROXITANE PERACETIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

iron blue; Hamburg Blue; Paris Blue; bronze blue; celestial blue; cyanine; Haarlem blue; oriental blue; potash blue; Turnbull's blue Cas no :25869-00-5

4-Methylbenzenesulfonamide; Pasam; p-TSA; PTSA; Toluene-4-sulfonamide; 4-Toluenesulfonic Acid Amide; Para-Toluenesulphonamide; P-Tosylamide; Toluol-4-sulfonamid (German); Tolueno-4-sulfonamida (Spanish); Toluène-4-sulfonamide (French) CAS NO: 70-55-3

P-Toluenesulfonic acid (PTSA) is an organic compound with the chemical formula C7H8O3S.
P-Toluenesulfonic acid (PTSA) is a member of the class of organic compounds known as benzenesulfonic acids or toluenesulfonic acids.
The "p" in PTSA indicates the position of the substituent (sulfonic acid group) on the para position of the toluene ring.

CAS Number: 104-15-4
EC Number (EINECS): 203-180-0

PTSA, p-Methylbenzenesulfonic acid, Tosic acid, Toluene-p-sulfonic acid, p-Toluene sulphonic acid, 4-Methylbenzenesulfonic acid, Tosylate, Toluene-p-sulphonic acid, p-Toluene sulphonate, 4-Methylbenzenesulfonate, p-Toluene sulphonate, Toluene-p-sulphate, Tosyl acid, 4-Toluenesulfonic acid, p-Toluene sulphonate, 4-Toluene sulphonic acid, Tosic acid, PTSA hydrate, Tosic acid hydrate, Toluene-p-sulphonate, p-Toluene sulphonate, Tosyl acid, 4-Methylbenzenesulphonic acid, Tosylate hydrate, p-Toluene sulphonate, 4-Toluenesulfonate, 4-Methylbenzenesulfonate, Tosyl acid, p-Toluene sulphonate, 4-Toluene sulphate, Tosyl acid hydrate, Tosylate hydrate, PTSA hydrate, Toluene-p-sulphonate, Tosyl acid hydrate, Tosyl acid hydrate, Tosic acid hydrate, p-Methylbenzenesulphonic acid, 4-Toluene sulphonate, 4-Toluenesulphonic acid, Toluene-p-sulphate, Tosic acid hydrate, p-Methylbenzenesulfonic acid, 4-Methylbenzenesulphonic acid, p-Tolylsulfonic acid, Tosylate hydrate, Toluene-p-sulfonic acid, 4-Toluene sulphonate, Tosyl acid, Tosylate hydrate, Toluene-p-sulphonate, PTSA hydrate, 4-Toluenesulfonic acid, Tosyl acid



APPLICATIONS


P-Toluenesulfonic acid (PTSA) is extensively used as a catalyst in esterification reactions for the synthesis of various esters.
P-Toluenesulfonic acid (PTSA) plays a crucial role in promoting the Fisher esterification process, converting carboxylic acids and alcohols into esters.
P-Toluenesulfonic acid (PTSA) is employed in the synthesis of flavors and fragrances, contributing to the production of aromatic compounds.

P-Toluenesulfonic acid (PTSA) is a key component in the preparation of surfactants and detergents, enhancing their cleaning properties.
In pharmaceutical synthesis, PTSA serves as a catalyst for the formation of drug intermediates and active pharmaceutical ingredients (APIs).
P-Toluenesulfonic acid (PTSA) finds application in the production of specialty polymers, where it acts as a polymerization initiator.

P-Toluenesulfonic acid (PTSA) is utilized in the synthesis of plasticizers, improving the flexibility and performance of polymers.
P-Toluenesulfonic acid (PTSA) plays a role in the production of ion exchange resins, which have applications in water treatment processes.
P-Toluenesulfonic acid (PTSA) is involved in the synthesis of dyes and pigments, contributing to the vibrant coloration of textiles and materials.
In the field of organic synthesis, PTSA is used for the cleavage of protecting groups in chemical reactions.

P-Toluenesulfonic acid (PTSA) is employed in the manufacturing of photographic chemicals, contributing to the development of photographic materials.
P-Toluenesulfonic acid (PTSA) is a catalyst in the acylation of aromatic compounds, facilitating the introduction of acyl groups.
P-Toluenesulfonic acid (PTSA) is utilized in the synthesis of specialty solvents, enhancing the efficiency of certain chemical reactions.

P-Toluenesulfonic acid (PTSA) is involved in the preparation of chemical intermediates for the production of agrochemicals and pesticides.
P-Toluenesulfonic acid (PTSA) plays a role in the synthesis of pharmaceutical intermediates, contributing to the pharmaceutical industry's drug development.
P-Toluenesulfonic acid (PTSA) is used in the formulation of electrolytes for electrochemical cells and batteries.
In the production of coatings and adhesives, PTSA contributes to the formulation of bonding agents.

P-Toluenesulfonic acid (PTSA) finds application in the preparation of analytical reagents for laboratory use.
P-Toluenesulfonic acid (PTSA) is employed in the manufacturing of inkjet inks, contributing to the stability and performance of ink formulations.

P-Toluenesulfonic acid (PTSA) is utilized in the production of specialty waxes and lubricants for various industrial applications.
P-Toluenesulfonic acid (PTSA) plays a role in the synthesis of fine chemicals used in the development of high-performance materials.
P-Toluenesulfonic acid (PTSA) is involved in the formulation of heat transfer fluids, contributing to efficient heat exchange in industrial processes.

P-Toluenesulfonic acid (PTSA) is used in the preparation of chemical reagents for nucleic acid synthesis in molecular biology.
In the field of nanotechnology, PTSA is employed in the synthesis of nanomaterials with tailored properties.
P-Toluenesulfonic acid (PTSA)'s versatility and reactivity make it a valuable tool in research, development, and industrial processes across multiple sectors.

P-Toluenesulfonic acid (PTSA) is utilized as a catalyst in the synthesis of resins and adhesives, contributing to their chemical stability.
In the field of biochemistry, PTSA is involved in the preparation of reagents for peptide synthesis.
P-Toluenesulfonic acid (PTSA) finds application in the manufacturing of specialty chemicals used in the paper and pulp industry.

P-Toluenesulfonic acid (PTSA) serves as a catalyst in the acetylation of alcohols, facilitating the production of acetate esters.
P-Toluenesulfonic acid (PTSA) is employed in the synthesis of specialty coatings for corrosion protection in various industries.
In the petrochemical sector, PTSA is used in the alkylation of aromatics, a crucial step in the production of high-octane fuels.
P-Toluenesulfonic acid (PTSA) plays a role in the formulation of metal-complex dyes used in the textile and leather industries.

P-Toluenesulfonic acid (PTSA) is utilized in the synthesis of plastic additives, enhancing the properties of plastic materials.
P-Toluenesulfonic acid (PTSA) contributes to the formulation of electrolytes for supercapacitors, improving energy storage capabilities.
P-Toluenesulfonic acid (PTSA) finds application in the preparation of chemical reagents for DNA sequencing and analysis.

P-Toluenesulfonic acid (PTSA) is involved in the manufacturing of specialty resins used in the production of coatings and finishes.
In the pharmaceutical industry, PTSA is employed in the synthesis of prodrugs and pharmaceutical intermediates.
P-Toluenesulfonic acid (PTSA) is used in the production of specialty surfactants for use in cleaning and personal care products.

P-Toluenesulfonic acid (PTSA) plays a role in the synthesis of specialty waxes used in the formulation of polishes and coatings.
P-Toluenesulfonic acid (PTSA) is employed in the preparation of chemical intermediates for the production of herbicides and fungicides.
P-Toluenesulfonic acid (PTSA) is used in the synthesis of liquid crystal materials, contributing to advancements in display technologies.

In the field of nanomaterials, PTSA is utilized in the preparation of nanoparticles with tailored properties.
P-Toluenesulfonic acid (PTSA) serves as a catalyst in the transesterification of triglycerides, a key step in biodiesel production.

P-Toluenesulfonic acid (PTSA) is involved in the formulation of heat transfer fluids, contributing to efficient thermal management in industrial processes.
P-Toluenesulfonic acid (PTSA) plays a role in the synthesis of specialty plastics with enhanced thermal and mechanical properties.
P-Toluenesulfonic acid (PTSA) is used in the production of fuel cells, contributing to advancements in clean energy technologies.

P-Toluenesulfonic acid (PTSA) finds application in the preparation of chemical reagents for protein purification in biotechnology.
P-Toluenesulfonic acid (PTSA) is employed in the synthesis of antioxidants, contributing to the stabilization of materials against oxidative degradation.

P-Toluenesulfonic acid (PTSA) is used in the formulation of adhesives for bonding a variety of materials, including plastics and metals.
P-Toluenesulfonic acid (PTSA)'s applications extend to the preparation of chemical intermediates for the production of various agrochemicals and fertilizers.

P-Toluenesulfonic acid (PTSA) is utilized in the synthesis of specialty detergents, enhancing their effectiveness in removing contaminants.
P-Toluenesulfonic acid (PTSA) plays a role in the formulation of corrosion inhibitors for protecting metal surfaces in various industrial processes.
P-Toluenesulfonic acid (PTSA) is employed in the production of specialty paints and coatings, contributing to improved adhesion and durability.

In the field of electrochemistry, PTSA is used in the preparation of electrolytes for redox flow batteries.
P-Toluenesulfonic acid (PTSA) is involved in the synthesis of ion exchange resins, which find applications in water treatment processes.
P-Toluenesulfonic acid (PTSA) is used in the production of specialty adhesives for bonding materials in challenging environments.
P-Toluenesulfonic acid (PTSA) serves as a key component in the formulation of liquid crystal materials used in the electronics and display industries.

P-Toluenesulfonic acid (PTSA) is employed in the synthesis of specialty monomers for the production of high-performance polymers.
In the field of catalysis, PTSA plays a role in asymmetric transformations, enabling the synthesis of chiral compounds.

P-Toluenesulfonic acid (PTSA) is utilized in the manufacturing of specialty lubricants, contributing to improved performance in various applications.
P-Toluenesulfonic acid (PTSA) finds application in the synthesis of photoactive materials for photonic devices and sensors.
P-Toluenesulfonic acid (PTSA) is involved in the production of specialty waxes used in formulations such as polishes and coatings.

P-Toluenesulfonic acid (PTSA) is employed in the preparation of chemical intermediates for the synthesis of pharmaceuticals and agrochemicals.
P-Toluenesulfonic acid (PTSA) serves as a reagent in the synthesis of surfactants, contributing to their emulsifying and dispersing properties.
P-Toluenesulfonic acid (PTSA) is used in the synthesis of specialty resins for the production of high-quality inks and coatings.

In the field of analytical chemistry, PTSA is employed for sample preparation and derivatization in chromatographic techniques.
P-Toluenesulfonic acid (PTSA) finds application in the production of specialty inorganic salts, utilized in various industrial processes.
P-Toluenesulfonic acid (PTSA) is utilized in the synthesis of specialty plastic materials, enhancing their thermal and mechanical properties.

P-Toluenesulfonic acid (PTSA) is involved in the formulation of electrolytes for electrochemical capacitors, contributing to their energy storage capabilities.
P-Toluenesulfonic acid (PTSA) is used in the preparation of metal-organic frameworks (MOFs), which have applications in gas storage and separation.
P-Toluenesulfonic acid (PTSA) plays a role in the synthesis of specialty polymers with controlled molecular weights and architectures.
P-Toluenesulfonic acid (PTSA) is employed in the production of corrosion-resistant coatings for metal surfaces in harsh environments.

P-Toluenesulfonic acid (PTSA) serves as a catalyst in the production of biodiesel from triglycerides, facilitating transesterification reactions.
P-Toluenesulfonic acid (PTSA) is used in the formulation of heat transfer fluids, contributing to efficient heat exchange in various industrial processes.
In the field of nanotechnology, PTSA is involved in the synthesis of nanomaterials with tailored properties for diverse applications.



DESCRIPTION


P-Toluenesulfonic acid (PTSA) is an organic compound with the chemical formula C7H8O3S.
P-Toluenesulfonic acid (PTSA) is a member of the class of organic compounds known as benzenesulfonic acids or toluenesulfonic acids.
The "p" in PTSA indicates the position of the substituent (sulfonic acid group) on the para position of the toluene ring.

P-Toluenesulfonic acid (PTSA) is a colorless to light yellow liquid with a faint odor.
Known for its strong acidity, P-Toluenesulfonic acid (PTSA) is a versatile organic compound widely used in various chemical processes.
The chemical structure of P-Toluenesulfonic acid (PTSA) consists of a toluene ring with a sulfonic acid group attached to the para position.
P-Toluenesulfonic acid (PTSA) is soluble in organic solvents and miscible in water, enhancing its applicability in different reaction environments.

P-Toluenesulfonic acid (PTSA) plays a crucial role as a catalyst in organic synthesis reactions, facilitating the formation of esters and other compounds.
As a sulfonic acid, PTSA is a powerful proton donor, making it effective in promoting acid-catalyzed reactions.

Its high reactivity and stability make PTSA a popular choice in laboratory and industrial settings for numerous applications.
P-Toluenesulfonic acid (PTSA) is commonly employed in esterification reactions for the synthesis of flavors, fragrances, and pharmaceutical intermediates.

P-Toluenesulfonic acid (PTSA)'s strong acid properties also make it valuable in acid-catalyzed dehydration reactions.
In addition to catalysis, PTSA is used in the production of specialty chemicals, detergents, and surfactants.

P-Toluenesulfonic acid (PTSA) hydrate is a hydrated form of the acid, offering specific advantages in certain applications.
P-Toluenesulfonic acid (PTSA) is often utilized in the manufacturing of polymers and plastics as a key component in the synthesis process.
P-Toluenesulfonic acid (PTSA)'s solubility in various organic solvents makes it a suitable reagent in customizing reaction conditions.

Due to its stability under proper storage conditions, PTSA is a reliable choice for chemical processes.
P-Toluenesulfonic acid (PTSA) is employed in the preparation of reagents for analytical chemistry and molecular biology applications.

P-Toluenesulfonic acid (PTSA) is known for its compatibility with a wide range of substrates, enhancing its versatility in different reactions.
P-Toluenesulfonic acid (PTSA) is a non-flammable liquid, contributing to its safety in handling and storage.
Its distinct odor, although faint, is characteristic and recognizable in laboratory environments.
P-Toluenesulfonic acid (PTSA)'s strong affinity for water makes it hygroscopic, necessitating careful handling to prevent moisture absorption.

P-Toluenesulfonic acid (PTSA) is a valuable tool in organic synthesis for introducing functional groups and modifying molecular structures.
Its effectiveness as a sulfonating agent is harnessed in the synthesis of dyes, pigments, and specialty chemicals.
P-Toluenesulfonic acid (PTSA) is often used in the synthesis of fine chemicals where precise control over reaction conditions is crucial.

P-Toluenesulfonic acid (PTSA)'s presence in various industrial processes highlights its importance in chemical manufacturing.
P-Toluenesulfonic acid (PTSA)'s impact extends to pharmaceutical research, where it serves as a catalyst in drug synthesis.
Known for its utility and reliability, PTSA continues to be a key component in the toolkit of synthetic chemists and researchers.



PROPERTIES


Chemical Formula: C7H8O3S
Molecular Weight: Approximately 172.20 g/mol
Physical State: Liquid
Color: Colorless to light yellow
Odor: Faint
Melting Point: 106-109 °C (223-228 °F)
Boiling Point: Decomposes before boiling
Density: Approximately 1.29 g/cm³
Solubility in Water: Soluble
Solubility in Organic Solvents: Miscible with many organic solvents
pH: Highly acidic
Refractive Index: Typically around 1.51
Flash Point: Non-flammable
Autoignition Temperature: Not applicable as it is non-flammable
Vapor Pressure: Negligible
Viscosity: Low viscosity liquid
Hygroscopicity: Absorbs moisture from the air
Corrosivity: Can be corrosive to certain metals and materials
Compatibility: Compatible with a wide range of organic solvents
Miscibility: Miscible with water and various organic solvents
Acidity: Strong acid with a dissociation constant (pKa) around -2
Hazardous Polymerization: Will not occur
Stability: Stable under normal storage conditions
Flammability: Non-flammable



FIRST AID


Inhalation:

Remove to Fresh Air:
If inhalation exposure occurs, immediately move the affected person to an area with fresh air.
Ensure proper ventilation and access to uncontaminated air.

Seek Medical Attention:
If respiratory distress persists or if there are signs of respiratory irritation, seek medical attention promptly.
Provide supportive care, including oxygen, if necessary.


Skin Contact:

Remove Contaminated Clothing:
In case of skin contact, promptly remove contaminated clothing to minimize further exposure.
Cut rather than pull clothing away to avoid additional skin contact.

Rinse with Water:
Rinse the affected skin area with plenty of water for at least 15 minutes.
Use mild soap if available and continue rinsing to ensure thorough removal of the substance.

Seek Medical Attention:
If irritation, redness, or chemical burns develop, seek medical attention promptly.
Provide healthcare professionals with information about the specific PTSA product and the nature of exposure.


Eye Contact:

Flush Eyes with Water:
If PTSA comes into contact with the eyes, immediately flush the eyes with gently flowing water for at least 15 minutes.
Hold the eyelids open to ensure thorough rinsing.

Seek Immediate Medical Attention:
Even if irritation is minimal, seek immediate medical attention.
Remove contact lenses after the initial eye rinse.


Ingestion:

Rinse Mouth:
If PTSA is ingested accidentally, rinse the mouth with water.
Do not induce vomiting unless instructed to do so by medical professionals.

Seek Immediate Medical Attention:
Seek immediate medical attention and provide healthcare providers with information about the ingested substance.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles or face shield, and protective clothing, to minimize skin and eye contact.
Use respiratory protection if handling in conditions where vapors or mists may be generated.

Ventilation:
Work in a well-ventilated area or use local exhaust ventilation to control airborne concentrations.
If handling in an enclosed space, ensure proper ventilation systems are in place to minimize inhalation risks.

Avoidance of Contact:
Avoid direct skin and eye contact with PTSA.
Take precautions to prevent inhalation of vapors, mists, or dust.
Minimize exposure through the use of engineering controls and PPE.

Handling Procedures:
Follow good laboratory or industrial practices when working with PTSA.
Use appropriate tools and equipment to minimize the generation of dust or aerosols during handling.

Spill Response:
In case of a spill, use suitable absorbent materials to contain and clean up the spilled substance.
Dispose of waste according to local regulations and in accordance with the product's safety data sheet (SDS).

Storage Compatibility:
Store PTSA away from incompatible materials, such as strong bases, reducing agents, and reactive metals.
Check compatibility with storage containers to prevent chemical reactions.

Labeling:
Ensure containers are properly labeled with the correct product information, hazard symbols, and safety precautions.
Maintain clear and visible labeling on secondary containers in case of transfer.


Storage:

Temperature:
Store PTSA in a cool, well-ventilated area, away from heat sources and direct sunlight.
Avoid exposure to extreme temperatures, as excessive heat may affect the stability of the substance.

Container Integrity:
Ensure that storage containers are tightly sealed to prevent contamination or evaporation.
Regularly inspect containers for any signs of damage or leaks.

Ventilation During Storage:
If stored in an enclosed area, provide adequate ventilation to prevent the accumulation of vapors.

Storage Conditions:
Store PTSA in accordance with the manufacturer's recommendations.
Keep the substance away from incompatible materials and follow guidelines for the storage of corrosive substances.

Separation from Food and Feed:
Store PTSA away from food, beverages, and animal feed.
Use separate storage areas to avoid cross-contamination.

Handling Precautions:
Follow proper handling procedures when transferring PTSA between containers or dispensing it for use.
Minimize the risk of spills during storage and handling.

Fire Prevention:
PTSA is generally non-flammable, but it is advisable to keep it away from open flames, sparks, or potential ignition sources.
Store in areas compliant with fire safety regulations.

Emergency Response:
Have appropriate emergency response equipment, such as spill containment materials and fire extinguishers, readily available.

cas no 70-55-3 4-Methylbenzenesulfonamide; Pasam; p-TSA; PTSA 70 ; Toluene-4-sulfonamide; 4-Toluenesulfonic Acid Amide; Para-Toluenesulphonamide; P-Tosylamide; Toluol-4-sulfonamid (German); Tolueno-4-sulfonamida (Spanish); Toluène-4-sulfonamide (French); p-TOLUENE SULFONAMIDE 70;

polyvinyl alcohol

DESCRIPTION:

PU Catalyst DMDEE is suitable for water curing systems and is a strong foaming catalyst.
Due to the steric hindrance of amino groups, the storage period of NCO components can be prolonged.

CAS No.:6425-39-4
EC Number, 229-194-7
Chemical Name:2,2-Dimorpholinodiethylether
Molecular weight：244.33

SYNONYMS OF PU CATALYST DMDEE:
DMDEE;Niax« Catalyst DMDEE;4,4′-(oxydiethane-2,1-diyl)dimorpholine
Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-
Bis(2-morpholinoethyl) Ether, 4,4'-(Oxybis(ethane-2,1-diyl))dimorpholine,2,2-Dimorpholinodiethylether,2,2'-Dimorpholinodiethyl ether,4,4'-(Oxydiethylene)bis(morpholine),4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine, 2,2'-Dimorpholinyldiethyl ether
4,4’-(oxydi-2,1-ethanediyl)bis-morpholin;Dimorpholinodiethylether;BIS(2-MORPHOLINOETHYL) ETHER;BIS[2-(N-MORPHOLINO)ETHYL] ETHER;LUPRAGEN(R) N 106;4,4'-(3-OXAPENTANE-1,5-DIYL)BISMORPHOLINE;4,4-(OXYDI-2,1-ETHANEDIYL)BISMORPHOLINE;2,2'-DIMORPHOLINODIETHYL ETHER



PU Catalyst DMDEE is suitable for the catalytic reaction of NCO and water in systems such as TDI, MDI, and IPDI; Sinocat® DMDEE is mainly used In one-component rigid polyurethane foam system, PU Catalyst DMDEE can also be used for polyether and polyester polyurethane soft foam, semi-rigid foam, CASE material, etc.
The addition amount accounts for 0.3-0.55% of the polyether/ester component.


PU Catalyst DMDEE is an acronym for dimorpholinodiethyl ether but is almost always referred to as DMDEE (pronounced dumdee) in the polyurethane industry.
PU Catalyst DMDEE is an organic chemical, specifically a nitrogen-oxygen heterocycle with tertiary amine functionality.

PU Catalyst DMDEE is a catalyst used mainly to produce polyurethane foam.
PU Catalyst DMDEE has the CAS number 6425-39-4 and is TSCA and REACH registered and on EINECS with the number 229-194-7.
The IUPAC name is 4-[2-(2-morpholin-4-ylethoxy)ethyl]morpholine and the chemical formula C12H24N2O3.

APPLICATIONS OF PU CATALYST DMDEE:
PU Catalyst DMDEE catalyst is a good blowing catalyst that does not cause cross-linking.
When used in moisture-cured systems, PU Catalyst DMDEE provides a stable prepolymer with a rapid cure.
PU Catalyst DMDEE can also be used in flexible polyester-based urethane foams, as well as semiflexible foams and HR molded foams.



USES OF PU CATALYST DMDEE:
PU Catalyst DMDEE tends to be used in one-component rather than 2-component polyurethane systems.
Its use has been investigated in polyurethanes for controlled drug release and also adhesives for medical applications.

Its use as a catalyst including the kinetics and thermodynamics have been studied and reported on extensively.
PU Catalyst DMDEE is a popular catalyst along with DABCO.






CHEMICAL AND PHYSICAL PROPERTIES OF PU CATALYST DMDEE:
Item, Standard
Appearance, Colorless transparent liquid
Chromaticity, ＜2
Water content, ≤0.1%
Content, ≥99%
Color Amber
Flash point, PMCC, °C (°F) 166 (330)
Freezing point, °C -28
Initial Boiling point, °C 309
pH 10.3
Specific gravity, 20/20°C 1.06
Vapor pressure, mm Hg, 20°C < 1
Viscosity, cSt, 15.5°C (60°F) 29
VOC Content, %, by ASTM D 2369 76
Water solubility, % > 10
CAS:, 6425-39-4
MF:, C12H24N2O3
MW:, 244.33
EINECS:, 229-194-7
Boiling point, 309 °C(lit.)
density, 1.06 g/mL at 25 °C(lit.)
refractive index, n20/D 1.484(lit.)
Fp, 295 °F
CAS DataBase Reference, 6425-39-4(CAS DataBase Reference)
EPA Substance Registry System, Morpholine, 4,4'-(oxydi-2,1-ethanediyl) bis-(6425-39-4)

Product Name:
Dimorpholinodiethyl ether
Other Name:
Morpholine,4,4′-(oxydi-2,1-ethanediyl)bis-;Morpholine,4,4′-(oxydiethylene)di-;4,4′-(Oxydi-2,1-ethanediyl)bis[morpholine];Bis(morpholinoethyl) ether;2,2′-Dimorpholinodiethyl ether;β,β′-Dimorpholinodiethyl ether;4,4′-(Oxydiethylene)bis[morpholine];4,4′-(Oxydiethylene)dimorpholine;Dimorpholinodiethyl ether;Texacat DMDEE;Jeffcat DMDEE;Di(2-morpholinoethyl) ether;PC CAT DMDEE;Bis[2-(4-morpholino)ethyl] ether;Dabco DMDEE;NSC 28749;U-CAT 660M;Bis(2-morpholinoethyl) ether;DMDEE;4,4′-(Oxydi-2,1-ethanediyl)bismorpholine;Lupragen N 106;N 106;JD-DMDEE;442548-14-3
CAS No.:
6425-39-4
Molecular Formula:
C12H24N2O3
InChIKeys:
InChIKey=ZMSQJSMSLXVTKN-UHFFFAOYSA-N
Molecular Weight:
244.33
Exact Mass:
244.33
EC Number:
229-194-7
UNII:
5BH27U8GG4
NSC Number:
28749
DSSTox ID:
DTXSID9042170
HScode:
2934999090
PSA:
34.2
XLogP3:
-0.6
Appearance:
Liquid
Density:
1.0682 g/cm3 @ Temp: 20 °C
Boiling Point:
176-182 °C @ Press: 8 Torr
Flash Point:
295 °F
Refractive Index:
1.482


SAFETY INFORMATION ABOUT PU CATALYST DMDEE:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

Purac FCC is a colorless to yellow syrupy liquid.
Purac FCC has a mild acid taste and is widely used as an acidulant in the food industry.


CAS Number: 50-21-5
EC Number: 200-018-0
INCI Names: LACTIC ACID
Molecular Formula: C3H6O3



L-lactic acid, PURAC 50-100, PURAC 80 FG, PURAC 88-LT, 88-T, PURAC FCC 50, FCC 80, FCC 85, FCC 88, PURAC FIT Plus 90, PURAC HiPure 51, HiPure 90, PURAC HS 50, HS 80, HS 88, HS 90, HS 93, HS 95, HS 100, PURAC PF 90, PURAC PH 91, PURAC UltraPure 50, UltraPure 90, PURAC Vin, PURAC DEX 185, PURAC HS Pure 90, PURAC HS Pure 50, Lactic Acid 50% NATL FCC, Purac FCC 50, Unilac LA50, Tisulac, Espiritin, HiPure 90, l-lacticaci, Lactic L-Milchsàure, α-hydroxypropionic acid, 2-hydroxypropanoic acid, 2-Hydroxypropionic acid, 2-Hydroxypropanoic acid, DL-Lactic acid, DL-Lactic acid, 2-Hydroxypropionic acid, Acidum lacticum,
Lactic Acid 80% Pdr w/silca, Lactic Acid 80% , Unilac LA80, Tisulac, Espiritin, HiPure 90, l-lacticaci, Lactic L-Milchsàure, α-Hydroxypropanoic acid,
lactic acid, 2-hydroxypropanoic acid, DL-Lactic acid, 50-21-5, 2-hydroxypropionic acid,



Purac FCC is the natural L(+) lactic acid, which is produced by fermentation from sugar.
Purac FCC’ s primary functions are to preserve and flavor.


Purac FCC is used organic acid for industrial purposes.
Purac FCC is a hydroxycarboxylic acid, so it contains both a carboxyl group and a hydroxyl group.
Purac FCC is therefore also referred to as 2-hydroxypropionic acid, but according to IUPAC nomenclature recommendations, the name 2-hydroxypropionic acid should be used.


Purac FCC's Chemical Formula is C3H6O3.
Purac FCC is produced as natural L-Lactic acid by fermentation of carbohydrates like sugar or starch.


Purac FCC is used in cosmetic compositions for pH adjustment and has good affinity for skin and hair.
Purac FCC improves skin hydration, removes dead cells and hair films (dandruff) having keratolytic action, hair shines.
Purac FCC is responsible for the tang that hits the mouth when eating dry aged beef.


Purac FCC is produced as natural L-Lactic acid by fermentation of carbohydrates like sugar or starch.
Purac FCC's Chemical Formula is C3H6O3.
An organic acid, Purac FCC, is used to reduce alkalinity without adding sulphate and chloride ions.


Purac FCC can help stimulate collagen and strengthen the skin, which equals fewer fine lines and wrinkles.
The hydroxy acids exfoliate the top layer of skin, helping smooth and even complexion, keep pores unclogged, brighten skin and even fade dark marks and discoloration.


Purac FCC is a versatile organic acid.
Purac FCC is soluble in water and in ethanol.
The inclusion of additional Purac FCC prior to rennetting overcomes this shortage and improves the curd yield.


The salts and esters of Purac FCC are called lactates.
A concentrated solution of Purac FCC is typically a mixture of lactic acid lactate and lactic acid.
Purac FCC appears as a colorless to yellow odorless syrupy liquid.


Purac FCC is a colorless to yellow/brown liquid.
Store Purac FCC in a tightly closed container.
Store Purac FCC in a cool, dry, well-ventilated area away from incompatible substances.


Purac FCC can also be used for minor corrections in brewing PH can be used at higher levels for beer souring.
Purac FCC reduces the alkalinity levels of brewing liquor, stimulating maximum enzyme activity in the wort and enabling optimum pH levels throughout the whole brewing process.


Purac FCC improves extract yield and fermentation ability.
Purac FCC is suitable for beers where no other anions are needed, for example, lagers.
Purac FCC improves the clarity and stability of the finished product


Purac FCC is a ready-for-use acid used to reduce alkalinity in brewing liquor.
Purac FCC is Food Grade and made by fermentation of natural (beet or cane) sugar.
Purac FCC is a product of natural origin, obtained by fermentation of glucose.


Purac FCC is an Alpha Hydroxy Acid (AHA) and can be used to promote higher rates of desquamation and cell renewal.
Purac FCC is also a moistening compound.
Purac FCC belongs to a group of alpha hydroxy acids (AHA) which show exfoliating, moistening and anti-aging properties.


Purac FCC is presented in a dropper bottles holding 4fl oz, to ensure an accurate dosing of milk and achieve consistent results when cheese making.
In production, Purac FCC is usually added up so that the pH of the milk is 5.0.
The casein in fermented milk is coagulated (curdled) by Purac FCC and it is also responsible for the sour flavor of sourdough breads.


If the pH is not within the range of 5.3 - 5.8, make gradual additions (0.10 - 0.15 mL/L) of Purac FCC, mix and measure again.
Purac FCC, from Jungbunzlauer, is an organic acid, occurring naturally in the human body and in fermented foods.
Purac FCC is a natural preservative and pH regulator.


Purac FCC is an organic acid with wide-reaching industrial applications.
Purac FCC specification makes it especially useful for food and beverage production, as well as pharmaceutical and cosmetic products.
Purac FCC is a versatile organic acid.


In its liquid state Purac FCC is colourless.
Purac FCC is one of the alpha-hydroxy acids (AHA’s).
These acids occur naturally in fruits, sugar cane and milk.


Purac FCC increasing wort's acidity and improving both mashing and fermentation.
The exact dosage depends on the alkalinity of the water used, the salts added and the malts used in the recipe.
Purac FCC is recommended to carry out a pH measurement of the mash before adding the product.


In nature Purac FCC exists in sour milk, yoghurts, sour rye soups and silages.
Purac FCC appears in two optical forms L and D, out of which only L-lactic acid is biologically active and is a natural element of the skin and hair.
Purac FCC is one of the main part of NMF – natural moistening factor, which is responsible for proper hydration of the epidermis.


Purac FCC stabilizes process of epidermis exfoliation in a very delicate way.
Purac FCC is an alpha hydroxy acid with both exfoliant and humectant properties.
Purac FCC is produced naturally in the body (it's the stuff that gives you a ‘stitch’ during a workout) and is also found in yogurt and milk.


Purac FCC dissolves very well in water.
Purac FCC is natural.
Purac FCC is approved as food additive E 270.


Purac FCC is a non dairy version that is part of a family of acids called Alpha Hydroxy Acids (AHA’s).
Purac FCC is produced from natural corn starch by advanced bio-fermentation and refining technology.
Purac FCC is a yellowish to colorless liquid, with a mildly acidic odour and taste.


Purac FCC is a naturally occurring alpha hydroxy acids (or AHAs) produced by fermentation of sugars.
Purac FCC is the alpha hydroxy acid most frequently used for peel products.
Purac FCC, also known as milk acid, is an organic compound with the chemical formula C3H6O3.


Purac FCC is a strong Alpha-Hydroxy Acid and hence will have excellent exfoliant properties, although these are weaker than, but second only to, Glycolic Acid.
AHA products should be a stand alone treatment product and not included in another product.


While AHA can be included in other products there are certain incompatibilities that may arise plus AHAs (because of the pH required for best effectiveness) may not allow other products (such as cleansing masks) to work properly, and vice versa.
Purac FCC is also a widely used organic acidulate, probably because it is classified as a weak acid.


While AHA can be included in other products there are certain incompatibilities that may arise plus AHAs (because of the pH required for best effectiveness) may not allow other products (such as cleansing masks) to work properly, and vice versa.
Purac FCC is also a widely used organic acidulate, probably because it is classified as a weak acid.


As with all manufacturing processes, we recommend lab scale trials in order to determine appropriate quantities.
Purac FCC is a liquid solution in water of about 80% purity.
Purac FCC, is an organic acid with applications in beer production as well as the cosmetic, pharmaceutical, food and chemical industries.


Purac FCC is produced from natural cornstarch by advanced bio-fermentation and refining technology.
Purac FCC is a yellowish to colorless liquid, having a mild acid odor and taste.
Purac FCC appears as a colorless to yellow odorless syrupy liquid.


Store Purac FCC in a tightly closed container.
Store Purac FCC in a cool, dry, well-ventilated area away from incompatible substances
Purac FCC is a colorless to yellow syrupy liquid.


Purac FCC is an alpha hydroxy acid that comes from milk.
As a result of its relatively greater molecular weight, Purac FCC's keratolytic action is milder than that of glycolic acid, thus preventing skin irritations.


Purac FCC is a strong Alpha-Hydroxy Acid and hence will have excellent exfoliant properties, although these are weaker than, but second only to, Glycolic Acid.
AHA products should be a stand alone treatment product and not included in another product.


Purac FCC is an anti-wrinkle and anti-pigmentation component available in both over-the-counter and professional-grade skincare products.
Purac FCC is derived from milk and belongs to the alpha-hydroxy acid (AHAs) class of anti-ageing compounds.
Glycolic acid and citric acid are two further examples of AHAs.


Purac FCC is a liquid solution in water of about 80% purity.
Purac FCC is an AHA.
Purac FCC is sufficient to add a few drops to 100 ml shampoo to adjust the pH.


Even as a moisturizing additive Purac FCC should not be applied more than 0,5%.
Dilute Purac FCC before use.
As with all of the acids, Purac FCC is important to let your skin acclimate to their use.


Purac FCC, also known as milk acid, is a chemical compound that plays a role in several biochemical processes.
Purac FCC is an alpha hydroxy acid that comes from milk.
As a result of its relatively greater molecular weight, Purac FCC's keratolytic action is milder than that of glycolic acid, thus preventing skin irritations.


Purac FCC comes in both R (D-) and S (L+) enantiomers which can be manufactured individually to near perfect optical purity.
This means Purac FCC is great in the production of other products which require a specific stereochemistry.
Purac FCC is a liquid solution in water of about 80% purity.


As with all manufacturing processes, we recommend lab scale trials in order to determine appropriate quantities.
Normally Purac FCC is titrated with a dilute solution of Lactic Acid (10 or 20% in water) until the desired pH is achieved.
Purac FCC is preferred as an acidulate as it tends to have less of a destabilizing effect on emulsions than Citric Acid.


Purac FCC has a mild acid taste and is widely used as an acidulant in the food industry.
Purac FCC is lactic acid naturally produced by fermentation from sugar.
With its mild acid taste, Purac FCC is fast emerging as the beverage acidulant of choice.


Purac FCC is a natural L-lactic acid that is produced by the fermentation of sugar.
Purac FCC has a mild acid taste and is widely used as an acidulate in the food industry.
The primary purpose of Purac FCC is to preserve flavor as well as the actual product.


Purac FCC acts as a moisturizing agent used in many skin care products.
Purac FCC has a mild acid taste and has the lowest irritation potential.



USES and APPLICATIONS of PURAC FCC:
Pharmaceutical technology uses Purac FCC to convert water-insoluble medicinal substances into salts of lactic acid (lactates); these are more soluble in water (example: ciprofloxacin).
In cosmetics, Purac FCC is used in skin creams and other products to treat acne.


Purac FCC is used to make cultured dairy products, as a food preservative, and to make chemicals.
Purac FCC has a role as a Daphnia magna metabolite and an algal metabolite.
Purac FCC is functionally related to a propionic acid.


Purac FCC is a conjugate acid of a lactate.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar.
The concentrated form is used internally to prevent gastrointestinal fermentation.


Sodium lactate is the sodium salt of Purac FCC, and has a mild saline taste.
It is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the resulting Purac FCC to create a compound having the formula NaC3H5O3.
Purac FCC was one of active ingredients in Phexxi, a non-hormonal contraceptive agent.


This results in a mild but effective exfoliation of the horny layer and in the simultaneous regeneration of cells.
Purac FCC stimulates the production of collagen and glycosaminoglycans that make up the intercellular material.
Another advantage provided by Purac FCC is that it naturally hydrates the skin; this action results in increased formation of ceramides, thus enhancing the function of the keratin barrier.


Within the Personal Care sector, Purac FCC functions as an acidifier with moisturising, exfoliating and antibacterial properties.
When used topically, Purac FCC can assist with the removal of dead skin cells helping to renew the skin, improve skin texture and tone along with functioning as a humectant.


The casein in fermented milk is coagulated (curdled) by Purac FCC.
Purac FCC is produced natutally in the Lacto-fermentation of foods.
Some examples of these types of foods are Kimchi, Sauerkraut, sour beer, tsukemono, suan cai, atsara and yoghurt.


Purac FCC is used directly as the acidulant.
Pickled Vegetables uses of Purac FCC: Purac FCC is effective in preventing the spoilage of olives, gherkins, pearl onions and other vegetables preserved in brine.


Purac FCC is a vital ingredient in Ricotta Impastata, Mozzarella, Queso Blanco and other speciality cheeses and can be used in the production of sour milk products, such as Koumiss, Laban, Kefir, as well as some cottage cheeses.
Purac FCC is an Alpha Hydroxy Acid (AHA) and can be used to promote higher rates of desquamation and cell renewal.


Purac FCC can be used to adjust the pH of many formulations and can be used as a milder alternative to glycolic acid.
Purac FCC and its salt, Sodium Lactate, can be used as humectants.
Purac FCC is used in facial products and also body lotions and moisturisers, never directly on skin.


Purac FCC is also used as an acidifying agent.
Purac FCC is food grade and is used for the production of several types of cheeses.
Purac FCC is particularly useful when UHT, ultra-pasturized or powdered milk are used as the starting materials, since the heat treatments used in the production of these milks deactivates the lactose and prevents the cheese culture from being able to turn it fully into Purac FCC.


Confectionery products uses of Purac FCC: such as hard boiled candy, fruit gums with Purac FCC results in a mild acid taste, improved quality and longer shelf life.
Purac FCC has moistening effect as a result of its properties to bind water in upper layers of the epidermis.


Purac FCC is used to make cultured dairy products, as a food preservative, and to make chemicals.
Purac FCC is used as a solvent and acidulant in the production of foods, drugs, and dyes.
Purac FCC is also used as a mordant in woolen goods printing, a soldering flux, a dehairing agent, and a catalyst for phenolic resins.


In production, Purac FCC is usually added so that the pH of the milk reaches around 5.0.
The casein in fermented milk is coagulated (curdled) by Purac FCC and it is also responsible for the sour flavour of sourdough breads.
Purac FCC is mainly used to adjust the pH of cosmetic products and is added during the production of shampoos to increase the shine of the hair.


Purac FCC is easy to use in liquid form.
Purac FCC works well with hyaluronic acid and Vitamins A, B and C.
Purac FCC can also be used as a pH regulator: Purac FCC will lower the pH.


Purac FCC is used Soapmaking pH adjustment, increased firmness of bars and solid format products (especially if pre-neutralised with Lye).
Purac FCC is used to produce serial products or widely used in food, vintage, beverage, drugs, polymerization, textile, leather, tobacco, feed, plastic chemicals, pesticide, polymer solution and other industry.


Purac FCC is also recommended for body and scalp-care for it helps in case of dry skin as well as skin exfoliation and cornification.
Purac FCC has been used in the production of beer for decades, contributing a unique tartness to this popular beverage.
With its 80% concentration of Purac FCC, this specially formulated solution allows you to easily control the level of tartness in your product.


Whether you’re using Purac FCC to adjust the flavour of your beer or in other food production needs, Purac FCC is the perfect choice for creating a finished product that meets all quality standards while delighting consumers.
Purac FCC can be used to adjust the pH of many formulations and can be used as a milder alternative to glycolic acid.


Purac FCC is used to adjust the pH of cosmetic products
When making shampoos, Purac FCC is added to make the hair shiner
Often used as food or feed additives, Purac FCC can improve the flavor of food and prolong the shelf life.


Purac FCC is widely used in canned food, bread, flour, pastry, feed and other industries as a food flavor improver.
Purac FCC is especially suitable for the acidity adjustment of various solid and powdered foods.
Purac FCC's excellent pH adjustment function and antibacterial ability can effectively inhibit the growth of microorganisms and prolong the shelf life of food.


Purac FCC is used Skin care (Facial care, Facial cleansing, Body care, Baby care) Hair care (Shampoos, Conditioners & Styling)
Purac FCC is a natural L-lactic acid, which is produced by fermentation from sugar.
Purac FCC has a mild acid taste and is widely used as an acidulant in the food industry.


Purac FCC has a mild acid taste and is widely used as an acidulant in the food industry.
Purac FCC is naturally present in the hair, produces a glossy, attractive appearance and is used as a pH-regulator in all kinds of hair care formulations.
In anti-acne products, Purac FCC is used for its antimicrobial action.


The cosmetics with Purac FCC should be used with the utmost care for dry complexion.
Purac FCC regulates cellular skin regeneration, and improves skin structure and colour.
Purac FCC enhances the effects of other cosmetic preparations.


Purac FCC improves skin moistening for the skin becomes more soft and elastic.
Purac FCC influences the production of skin collagen by increasing thickness and strengthening the dermis.
Purac FCC increases the level of glycosaminoglycans that is compounds that absorb water as a sponge and provide hydration of deeper layers of the skin.


Purac FCC is classed as an advanced skincare ingredient and should not be used unless you understand the usage and applications of Lactic Acid.
Purac FCC is used acne Treatments & Skin Peels, Bee Keeping, In food production, To Extend shelf life of Meat,Fish & Poultry, Acidity regulator in drinks, In dairy products, Baking, Detergent, Animal Nutrition Supplement, and General Industry.


Purac FCC is widely used as an acidulent in the food industry, as well as for preservation and flavouring.
Purac FCC is used very useful to rejuvenate the skin by encouraging the shedding of old surface skin cells.
Purac FCC can reduce the appearance of fine lines, irregular pigmentation, age spots & decreases enlarged pores.


Purac FCC and its salt, Sodium Lactate, can be used as humectants.
Purac FCC is used skincare pH adjustment, humectancy, skin brightening, desquamation, exfoliation.
Purac FCC is used haircare pH adjustment, humectancy.


Purac FCC has an anti-microbial effect and is the basis for preservation by fermentation in many food products.
Purac FCC serves as a preservative, pH regulator and flavouring agent.
Purac FCC is primarily found in sour milk products, such as: koumiss, leban, yogurt, kefir, and some cottage cheeses.


Faster exfoliation of cells results in the growth of new ones.
Preparations with Purac FCC support the treatment of acne.
When using masques with Purac FCC pointwise (7.0-15.0%) one can try removing sun, acne and aging maculae.


After using preparations with Purac FCC one should protect the skin against sun.
Without the layers of cornified cells, “young” epidermis absorbs nourishing cosmetics considerably better.
Therefore, tonics, scrubs and masques with Purac FCC belong to basic cosmetics for the care of oily, mixed, acne and mature complexions.


The fastest growing use for Purac FCC is its use as a monomer for the production of polylactic acid or polylactide (PLA).
Applications for PLA include containers for the food and beverage industries, films and rigid containers for packaging, and serviceware (cups, plates, utensils).


The PLA polymer can also be spun into fibers and used in apparel, fiberfill (pillows, comforters), carpet, and nonwoven applications such as wipes.
Purac FCC is used in dyeing baths, as mordant in printing woolen goods, solvent for water-insoluble dyes (alcohol-soluble induline, nigrosine, spirit-blue).


Purac FCC is often used in creams & lotions at a lower concentration for a more gentle acid-based peel.
Purac FCC is used in cosmetic to biolifting for it makes the skin elastic, evens wrinkles, brightens discolorations and narrows pores.
Purac FCC is also used in conditioners and shampoos because it activates hair bulbs, accelerating hair growth.


The combination of mild peeling, regeneration and hydration that Purac FCC offers, makes it an ideal peeling treatment for sensitive and dehydrated skin and a good choice for skin that will undergo chemical peeling for the first time.
The Purac FCC in combination with the pH result in targeted actions and indications.


Purac FCC is applied to adjust the pH of cosmetic products such as shampoo and shower gel or creams and lotions.
As Purac FCC is evident from the name, it reduces the pH of a product.
In addition to pH-regulation Purac FCC has excellent moisturizing effects.


An exception is the application in chemical peels.
Purac FCC is widely used in a range of food, industrial and manufacturing processes.
Purac FCC can be used for adjusting pH in the mash or sparge water.


Purac FCC may vary in colour from transparent to pale yellow.
Purac FCC is used a pH meter or test strips to control the pH.
Purac FCC may also be used in the final beer or wine for adding acidity.


Purac FCC is used to treat dry, rough & scaly skin.
Purac FCC may also be used for other conditions as determined by your doctor.
Normally Purac FCC is titrated with a dilute solution of Lactic Acid (10 or 20% in water) until the desired pH is achieved.


Purac FCC is used reducing chromates in mordanting wool.
Purac FCC is used manufacturing cheese, confectionery.
Purac FCC is used component of babies' milk formulas; acidulant in beverages; for acidulating worts in brewing.


Purac FCC is the natural L-Lactic acid produced by fermentation from sugar.
Purac FCC has a mild acid taste and is widely used as an acidulant in the food industry.
Purac FCC's primary functions are to preserve flavor.


Likewise, Purac FCC is used in lactofermentation and is used to preserve silages in feed production.
In technical applications, Purac FCC provides support through its biocidal effect and is therefore a component of disinfectant solutions and other cleaners.
In addition, Purac FCC is used for gentle decalcification.


It is preferred as an acidulate as Purac FCC tends to have less of a destabilizing effect on emulsions than Citric Acid.
Purac FCC is used treating dry, rough & scaly skin.
Purac FCC may also be used for other conditions as determined by your doctor.


Purac FCC is one of the popular food additives and ingredients in most countries.
Commonly Purac FCC is used as a preservative and antioxidant.
Purac FCC also has uses as a fuel additive, chemical intermediate, acidity regulator, and disinfectant.


Purac FCC is also used in dialysis solutions, which results in a lower incidence of side effects compared to Sodium Acetate which can also be used.
Purac FCC is used frequently in the cosmetic industry due to the effect of promoting collagen production, helping to firm the skin against wrinkles and sagging.


Purac FCC is used as an additive in animal nutrition.
Purac FCC has health promoting properties.
Purac FCC is used as a humectant, or moisturizer, in some cosmetics.


Purac FCC ia used as a mordant, a chemical that helps fabrics accept dyes, in textiles.
Purac FCC is also used in tanning leather.
Purac FCC is used in the manufacturing of lacquers and inks.


Purac FCC is food grade and is used for the production of several types of cheeses.
Purac FCC is particularly useful when UHT, ultra-pasteurised or powdered milk are used as the starting materials, since the heat treatments used in the production of these milks deactivates the lactose and prevents the cheese culture from being able to turn it fully into Purac FCC.


The inclusion of additional Purac FCC prior to rennetting overcomes this shortage and improves the curd yield.
Purac FCC is a vital ingredient in Ricotta Impastata, Mozzarella, Queso Blanco and other speciality cheeses and can be used in the production of sour milk products, such as Koumiss, Laban, Kefir, as well as some cottage cheeses.


Purac FCC is the principal building block for Poly Lactic Acid (PLA).
PLA is a biobased and bio-degradable polymer that can be used for producing renewable and compostable plastics.
Purac FCC is used to adjust the pH of the mash or the sparge water.


Purac FCC is used for Pilsner style lagers to reduce alkalinity.
Purac FCC used to reduce alkalinity without adding sulphate and chloride ions.
Purac FCC can also be used for minor corrections in brewing


Purac FCC can also cause micro peeling, which can help reduce various scars and age spots.
This is a great solution for people with sensitive or dry skin where exfoliants don’t work.
Purac FCC is used to treat dry, rough & scaly skin.


Purac FCC may also be used for other conditions as determined by your doctor.
Dilute Purac FCC before use.
As with all of the acids, Purac FCC is important to let your skin acclimate to their use.


For those whose skin is not used to the acids a slight stinging and redness may result.
If this occurs, Purac FCC reduce usage.
Purac FCC contains an alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn.


Purac FCC is used a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterwards.
Purac FCC reduces the alkalinity levels of brewing liquor stimulating maximum enzyme activity in the wort enabling optimum pH levels throughout the whole brewing process.


Purac FCC is used as a valuable component in biomaterials.
Purac FCC is used as a natural anti-bacterial agent in disinfecting products.
Purac FCC is used in the industrial processes.


PH can be used at higher levels for beer souring.
Purac FCC has a good moisturising effect on the skin and can be used in water based serums, gels, toners, creams and lotions.
Purac FCC can help the skin to look fresher and younger.


Purac FCC is especially beneficial in night creams and anti aging products.
When Purac FCC is used at higher concentrations, it can have an exfoliating effect.
Purac FCC will improve the skin's appearance and help to remove surface debris and dead skin cells.


Hair Care: Used in a hair pack, Purac FCC will cleanse a congested scalp for example, after a weave has been removed, having been on for several months.
Never use Purac FCC directly on the skin.


Best Purac FCC is added in stage 3 (cool down) when making creams and lotions.
Be aware that Purac FCC can make creams and lotions thinner or unstable so you need to start with a very strong and stable cream or lotion.
As a pH regulator, Purac FCC can be used to move the pH number lower (more acidic) for when using Preservative K which only functions correctly in a narrow pH range.


Often, Purac FCC is derived from milk, however, ours is made from maize or corn, and free from GMO.
Purac FCC is sold at an 80% concentration i.e. Purac FCC with 20% Water as an aqueous solution.
According to the Cosmetic Ingredient Database (CosIng), the functions of Purac FCC are: Buffering, Humectant, Skin Conditioning.


Purac FCC improves extract yield and fermentation ability
Purac FCC is suitable for beers where no other anions are needed for example lagers.
Purac FCC improves clarity and stability of the finished product.


Purac FCC concentration for chemical exfoliation, suitable for all skin types.
Purac FCC offers cellular regeneration, hydration and reduction of the appearance of wrinkles on the skin.
Typical use level of Purac FCC is between 1-20% in peels, creams, lotions, masks, cleansers.


Due to Purac FCC's acidity the final product needs to be tested for safe pH.
Optimal pH range of Purac FCC is from 3.5-5.0.
Some over the counter products, after adding Purac FCC, will separate as a result of the low pH, and need to be stabilized.


In many food products usually serves, Purac FCC is used as either as a pH regulator, as a preservative, or as a flavoring agent.
Purac FCC is used as an acidity regulator.
Purac FCC is effective in preventing the spoilage of vegetabels.


Purac FCC is often used as a milder alternative to glycolic acid in cosmetic formulations and can also be used to lower pH during manufacturing.
Purac FCC is produced by fermentation of glucose syrup from maize by using a bacterial strain.
Purac FCC is an acid and should never be used undiluted.


When used in proper concentrations (up to 5.0%), Purac FCC loosens intercellular cement.
Regular use of cosmetics with Purac FCC rejuvenates the epidermis and makes wrinkles even by means of a gradual exfoliation of dead cells of horny layer.


Purac FCC makes small surface wrinkles even and improves skin elasticity as well as firmness; it is an anti-aging ingredient; it helps in case of discolorations and small acne scars.
Purac FCC makes pores clear and shows antibacterial properties, hence, it prevents the creation of trouble spots that are all kinds of eczemas and blackheads; it helps in the treatment of acne.


Purac FCC is used soapmaking pH adjustment, increased firmness of bars and solid format products (especially if pre-neutralised with Lye).
Purac FCC is used Skincare pH adjustment, humectancy, skin brightening, desquamation, exfoliation.
Purac FCC is used Haircare pH adjustment, humectancy.


Skin Care: Depending on the strength of the dilution used, Purac FCC can be used as a pH regulator, a moisturiser or as a skin peel.
In the lower percentages, Purac FCC reduces Trans Epidermal Water Loss (TEWL) by supporting the skin's barrier function.
When applied, Purac FCC cleaves the bonds between keratinocytes on the external layer, thus reducing them and leading to gradual regeneration.


Purac FCC is also used in leather tanning, oil well acidizing, and as a plant growth regulator.
Purac FCC is applied in Petroleum Production and Refining, Soldering, Farming (Pesticides) ,Leather Tanning and Processing, Fur Dressing and Dyeing, Textiles (Printing, Dyeing, or Finishing).


Purac FCC is used as an excellent acidification agent for many dairy products.
Purac FCC is used as an enhance savory flavors.
In pharmaceutical technology, Purac FCC is used as a starting material for other substances.


Purac FCC is used in preparation of sodium lactate injections. Ingredient of cosmetics.
Purac FCC is used component of spermatocidal jellies.
Purac FCC is used for removing Clostridium butyricum in manufacturing of yeast; dehairing, plumping, and decalcifying hides.


Purac FCC is used solvent for cellulose formate.
Purac FCC is used flux for soft solder.
Purac FCC is used manufacturing lactates which are used in food products, in medicine, and as solvents.


Purac FCC is used plasticizer, catalyst in the casting of phenolaldehyde resins.
Purac FCC can be used as acidulent, flavoring agent and pH regulator in beverages, meat, sourdough, salads and dressings, confectionery and pickled vegetables.


Purac FCC is used in food and technical applications.
Liquid Purac FCC, as a 1:1 mixture of levorotatory and dextrorotatory lactic acid, is very commonly used for acid regulation in bakery and confectionery products or in beverages and for preservation.


-Material uses of Purac FCC:
Purac FCC is the monomer of polylactides or polylactic acids (PLA), which are used in various ways as biodegradable and biobased plastics.
Purac FCC has an antibacterial effect and is therefore added to liquid soaps, cleaners and detergents.

They develop their disinfecting effect optimally at a pH value of 3 to 4.
Purac FCC was and is also used as a contraceptive.
Purac FCC is used as a descaling agent in the tannery for descaling hides.

Purac FCC is also used for this purpose in the textile industry and printing companies.
Some cleaning tablets for coffee machines, soft drinks machines and similar appliances contain Purac FCC as a descaling agent.
Beekeepers use Purac FCC to treat bees against the Varroa mite, ensuring that the treated hives or honeycombs are brood free.
Arachnologists use Purac FCC to illuminate the prepared epigyne of female spiders or other chitin structures and to dissolve tissue debris.


-Beer brewing uses of Purac FCC:
Purac FCC is to lower the pH and add a bit of tartness.
Naturally add in small amounts or Purac FCC will become quite sour.


-Cheese making & Whipped Butter uses of Purac FCC:
Ricotta in particular and whipped butter in combination with GDL.
Ricotta Impastata, Mozzarella and Queso Blanco.


-Interesting non food uses for Purac FCC:
Purac FCC is the principal building block for Poly Lactic Acid (PLA) biodegradable plastics.
PLA is a biobased and bio-degradable polymer that can be used for producing renewable and compostable plastics.
Purac FCC is also being used in the cosmetics industry for acne treatment.


-Power supply uses of Purac FCC:
A number of foods are made directly through Purac FCC fermentation.
This mainly includes sour milk products such as sour milk, yogurt, kefir and buttermilk.
These are produced by infecting pasteurized milk with starter cultures of Purac FCC bacteria.

Other products include lacto-fermented vegetables such as sauerkraut, beetroot in some varieties of borscht, or kimchi, as well as sourdough and sourdough products.
Silage, fresh feed made sustainable by fermentation, is also based on Purac FCC fermentation.
As a food additive, Purac FCC carries the designation E 270.

Purac FCC is used in many different ways as an acidity regulator in the food and luxury goods industries, for example in baked goods, confectionery and occasionally in lemonades.
By changing the pH value in the food to a pH of about 4, the food is preserved, since colonization with other microorganisms is largely excluded.
In the form of the salts calcium lactate or calcium lactate gluconate Purac FCC can also be added for calcium enrichment.



CLAIMS OF PURAC FCC:
*Anti-acne Agents
*Antimicrobials
*Moisturizing Agents



FUNCTIONS OF PURAC FCC:
*In food, apart from its nutritional function for normal growth, Purac FCC improves flavor and taste, improves quality of food and beverage products such as confectionery, cake, milk powder, yogurt etc. as firming agent, buffering agent and flour regulator.
*Purac FCC increases effectiveness of antioxidants, prevents decolorization of fruits and vegetables.



FEATURES AND BENEFITS OF PURAC FCC:
*Purac FCC is very useful to rejuvenate the skin by encouraging the shedding of old surface skin cells
*Purac FCC can reduce the appearance of fine lines, irregular pigmentation, age spots & decreases enlarged pores
*Purac FCC is used good choice for first-time peel users or for those with sensitive skin
*Purac FCC is often used in creams & lotions at a lower concentration for a more gentle acid-based peel.



USE IN FOOD, PURAC FCC:
Purac FCC is a natural preservative found in several foods, including pickled vegetables, yoghurt, and baked goods.
Purac FCC is a cheap and minimally processed
Lactobacillus and Streptococcus cultures produce Purac FCC through fermentation.
The bacteria break down sugar to extract energy and produce Purac FCC as a byproduct.
Purac FCC helps regulate pH levels and prevents the growth of microorganisms, extending shelf life.



HOW TO USE PURAC FCC IN COSMETICS:
- Purac FCC is a product that does not apply to pure skin
- Purac FCC can be included as an ingredient in cosmetic compositions containing acidulant and water: serums, gels, tonics, masks, lotions, creams, shampoos, cleanses, etc.



BENEFITS AND APPLICATIONS OF PURAC FCC:
Purac FCC is used to treat hyperpigmentation, age spots, and other conditions that contribute to a dull, uneven complexion.
Purac FCC also enhances skin tone and minimises the appearance of pores.

Purac FCC promotes cell turnover and cell renewal, which are the processes through which your skin loses old cells and replaces them with new ones.
Purac FCC works really well for sensitive skin because of its milder nature as compared to other alpha-hydroxy acids.

Purac FCC is also a key component of over-the-counter lotions and creams for "chicken skin," i.e., pimples on the backs of the arms.
Purac FCC aids in the dissolution of the clog of skin cells that form around the hair follicle, smoothing out the bumpiness.
Purac FCC is commonly found in topical therapies for eczema, psoriasis, and rosacea.



THE PROPERTIES OF PURAC FCC:
The properties of Purac FCC
- Keratolytic exfoliates the skin by removing dead skin and scalp cells
- Stimulates collagen and elastin synthesis, promoting cell renewal
- Purac FCC improves skin grain and appearance pH
- Activates the emulsifier conditioner used in the manufacture of hair care compositions



BENEFITS OF PURAC FCC:
*Brightens a dull complexion
*Humectant and skin firmer
*Exfoliant
*Improves skin tone and texture
*Vegan Friendly
*GMO-free



FUNCTION OF PURAC FCC:
In food, apart from its nutritional function for normal growth, Purac FCC improves flavor and taste, improves quality of food and beverage products such as confectionery, cake, milk powder, yogurt etc. as firming agent, buffering agent and flour regulator.
Purac FCC increases effectiveness of antioxidants, prevents decolorization of fruits and vegetables.



BENEFITS OF PURAC FCC:
Purac FCC reduces the alkalinity levels of brewing liquor, stimulating maximum enzyme activity in the wort enabling optimum pH levels throughout the whole brewing process.
Purac FCC improves extract yield and fermentability.
Purac FCC is suitable for beers where no other anions are needed, for example, pilsner lagers.
Purac FCC can also be used to reduce the pH of final wort or products.



SUGGESTED BLENDS OF PURAC FCC:
Purac FCC works well in conjunction with Vitamin A, B and C.
Be sure to check the final pH level is not less than 3.5 when combining several acidic ingredients together.



HOW PURAC FCC WORKS:
Purac FCC works by removing the upper layer of skin cells, which is usually composed of dead skin cells.
Purac FCC also works by increasing the natural moisture retention capabilities of the skin to give your skin a hydrated look.



CONCENTRATION AND SOLUBILITY OF PURAC FCC:
Purac FCC is recommended that it should be used at a concentration of 1–5%.
Purac FCC is soluble in water, alcohol, and glycerol but is insoluble in oil.



HOW TO USE PURAC FCC:
Prepare the oil and water phases of your formulation separately.
Heat the oil and water phases using a double boiler.
Add Purac FCC to the water phase, accompanied by constant stirring.
Blend both the phases together using a mini-mixer or a large mixing brush



PHYSICAL and CHEMICAL PROPERTIES of PURAC FCC:
End Use: Food additive
Color: yellow, Clear, Colorless
Odor: Characteristic
pH: < 1.2 @ 25 °C (77 °F)
Boiling Point: 120 - 130 °C (248 - 266 °F)
Flash Point: Not applicable
Auto-ignition Temperature: > 400 °C (> 752 °F)
Viscosity, Dynamic: 5 - 60 mPa.s @ 25 °C (77 °F)
Supplier: Purac America Inc
CAS: 79-33-4
Applications: Flavor, Additive Preservative
Chemical Form: Liquid
Product: L-Lactic acid
Form: liquid
Grade: edible special

Color: fresh max. 50 apha
Color, 6 months, 25°C max. 50 apha
Odor: agreeable
Stereochemical purity (L-isomer): min. 95%
Assay: 87.5-88.5% w/w
Density: at 20°C 1.20-1.22 g/ml
Sulphated ash max.: 0.1%
Heavy metals total max.: 10 ppm
Iron max.: 10 ppm
Arsenic max.: 1 ppm
Calcium max.: 20 ppm
Chloride max.: 10 ppm
Sulphate max.: 20 ppm
Reducing sugars: passes test FCC
Molecular formula: CH3CHOHCOOH
Molecular weight: 90
Chemical name: 2-hydroxypropionic acid

Odor: odorless
Melting point/freezing point:
Melting point: 18 °C at 1.013 hPa
Initial boiling point and boiling range: 122 °C at 18,66 - 19,99 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 113 °C - closed cup
Autoignition temperature: 400 °C at 1.011,4 - 1.018,9 hPa
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 100 g/l at 20 °C - soluble

Partition coefficient: n-octanol/water:
log Pow: ca.-0,54 at 25 °C - Bioaccumulation is not expected.
Vapor pressure: No data available
Density: 1,25 g/cm3 at 15 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:
Surface tension 70,7 mN/m at 1g/l at 20 °C
Formula: H₃CCH(OH)COOH
MW: 90.08 g/mol
Boiling Pt: 122 °C (20 hPa)
Density: 1.11…1.21 g/cm³ (20 °C)
Storage Temperature: Ambient
MDL Number: MFCD00004520
CAS Number: 50-21-5
EINECS: 200-018-0

CAS: 50-21-5
MF: C3H6O3
MW: 90.08
EINECS: 200-018-0
Mol File: 50-21-5.mol
Lactic acid Chemical Properties
Melting point: 18°C
alpha: -0.05 º (c= neat 25 ºC)
Boiling point: 122 °C/15 mmHg (lit.)
density: 1.209 g/mL at 25 °C (lit.)
vapor density: 0.62 (vs air)
vapor pressure: 19 mm of Hg (@ 20°C)
FEMA: 2611 | LACTIC ACID
refractive index: n20/D 1.4262

Fp: >230 °F
storage temp.: 2-8°C
solubility: Miscible with water and with ethanol (96 per cent).
form: syrup
pka: 3.08(at 100℃)
Specific Gravity: 1.209
color: Colorless to yellow
Water Solubility: SOLUBLE
Merck: 145,336
JECFA Number: 930
BRN: 1209341
Stability: Stable.
Physical state: viscous
Color: colorless



FIRST AID MEASURES of PURAC FCC:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person. Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of PURAC FCC:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of PURAC FCC:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of PURAC FCC:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of PURAC FCC:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.



STABILITY and REACTIVITY of PURAC FCC:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

DESCRIPTION:

PURAC UltraPure is a novel, low odor, and colorless ultra-pure grade of natural Lactic Acid.
PURAC UltraPure is a versatile ingredient, with effects ranging from hydration to anti-aging.
Its action can be tuned by adjusting the use level and the pH of the product formulation.

CAS 79-33-4

SYNONYMS OF PURAC ULTRAPURE:
2-Hydroxypropionic Acid, Milk Acid, L-Lactic Acid



The anti-aging effects of PURAC UltraPure derive from its ability to stimulate exfoliation and cell renewal, moisturize, and increase dermal and epidermal thickness.
UltraPure Lactic Acid stimulates exfoliation of the Stratum Corneum.
PURAC UltraPure also stimulates cell renewal in the skin’s epidermis.
Through exfoliation and stimulation of cell renewal in these layers, smoother, younger looking skin is revealed.

The removal of skin pigmentation can be accelerated, promoting skin brightening and lightening.
Additionally, as PURAC UltraPure increases the thickness of the epidermis and the dermis, it results in firmer skin with reduced fine lines and wrinkles.
At higher pH formulations, PURAC UltraPure can be used as powerful humectant.

In lactate form, PURAC UltraPure displays extremely high water-holding capacity and has shown to have a superior plasticizing effect on the Stratum Corneum.
As a humectant, and key component of the skin’s Natural Moisturizing Factor (NMF), PURAC UltraPure provides significant, reliable, and intrinsic moisturization.

Corbion’s biobased PURAC UltraPure is natural and can be considered ‘the body’s own Alpha-Hydroxy Acid (AHA)’, since this form is exclusively produced by the metabolic conversion of glucose or glycogen in the body.



PURAC UltraPure is a unique, high-quality grade of L-Lactic Acid with an extremely low base odor and a water-clear appearance.
PURAC UltraPure is the purest natural Lactic Acid available and brings powerful moisturization and anti-aging properties to formulations where an exceptionally low base odor is required.


PURAC UltraPure by Corbion and supplied regionally by Brenntag Specialties in EMEA acts as an anti-aging agent.
PURAC UltraPure is based on L-lactic acid, produced by fermentation from cabohydrates.
L-lactic acid is natural and can be considered ‘the body’s own alpha-hydroxy acid (AHA).

Its ability to stimulate exfoliation and cell renewal in the skin's epidermis, as well as providing moisturization, PURAC UltraPure provides anti-aging benefits.
PURAC UltraPure helps to obtain smoother, younger and brighter looking skin, while also reducing skin pigmentation and thus enabling skin brightening and lightening.

Additionally, as PURAC UltraPure increases the thickness of the epidermis and the dermis, resulting in firmer skin with reduced fine lines and wrinkles.
At higher pH formulations, it can be used as powerful humectant.

PURAC UltraPure has an extremely low carbon footprint and is made with resource-efficient use of energy, materials and water.
PURAC UltraPure is effective for all skin types and it is used in skin care products.

PURAC UltraPure 90 is a unique, high-quality grade of L-Lactic Acid with an extremely low base odor and a water-clear appearance.
PURAC UltraPure is the purest natural Lactic Acid available and brings powerful moisturization and anti-aging properties to personal care formulations where an exceptionally low base odor is required.



PURAC UltraPure 90 by Corbion and supplied regionally by Brenntag Specialties in EMEA is a natural, safe, multi-functional grade that offers anti-aging & hydration properties.
PURAC UltraPure can be used as a powerful humectant at high pH formulations.


PURAC UltraPure displays extremely high water-holding capacity and has a superior plasticizing effect.
PURAC UltraPure provides significant, reliable, and intrinsic moisturization.
PURAC UltraPure can stimulate exfoliation and offers cell renewal and increased dermal and epidermal thickness.


PURAC UltraPure 90 also provides smooth, young looking skin and acceleration of removal of skin pigmentation and promotes skin brightening and lightening.
PURAC UltraPure gives firmer skin with reduced fine lines and wrinkles.
PURAC UltraPure is recommended for anti-aging and moisturizing solutions.



PURAC UltraPure Lactic Acid is a novel, low odor and colorless, ultra-pure grade of natural Lactic Acid.
PURAC UltraPure is a versatile ingredient, with effects ranging from hydration to anti-aging.
Its action can be tuned by adjusting the use level and the pH of the product formulation.

PURAC UltraPure 90 is a novel, low odor, and clear 90% purity grade natural Lactic Acid.
PURAC UltraPure is a versatile ingredient, with effects ranging from hydration to anti-aging.
PURAC UltraPure is also used as a food additive.



APPLICATIONS OF PURAC ULTRAPURE:
Personal Care Applications, Moisturization, Anti-aging


RECOMMENDED USES OF PURAC ULTRAPURE:
AHA Cleansers
Alpha Hydroxy Acid Cleansers
Anti Ageing Creams & Lotions
Beverages
Body Wash
Breweries
Buffer
Chemical Intermediate
Conditioners
Cosmetics
Dairy Products
Deliming Hides
Edible Oils
Ethyl Lactate
Exfoliant Scrub
Facial Cleaner
Flour Confectionery
Hair Care
Hair Conditioner
Humectant
Masks Cosmetic
Moisturizing Cream Formulations
Olives
pH Control
Pharmaceuticals
Pickles
Sequesterant
Shampoo
Shower Gels
Skin Care Products
Sugar Free Candy
Wine


CHEMICAL AND PHYSICAL PROPERTIES OF PURAC ULTRAPURE:
Grade
FCC
Certification
Kosher
Form
Liquid
Prohibited Uses
For intended use only. Not for the use in personal care industry
INCI
Lactic Acid
Appearance
liquid
Auto Ignition Temperature
> 400 °C (> 752 °F)
Boiling Point
120 - 130 °C (248 - 266 °F)
Color
yellow, Clear, Colorless
Density
1.2 g/cm3 @ 20 - 25 °C (68 - 77 °F)
Dynamic Viscosity
5 - 60 mPa.s @ 25 °C (77 °F)
Flash Point
Not applicable
Odor
characteristic
Partition Coefficient
Pow: -0.62
pH
< 1.2 @ 25 °C (77 °F)
Solubility in Water
completely miscible
Surface Tension
44 - 50 mN/m
Thermal Decomposition
> 200 °C (> 392 °F)



SAFETY INFORMATION ABOUT PURAC ULTRAPURE:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

Pure Pure Tung Oil, also known as China wood oil, is a drying oil obtained by pressing the seeds of the tung tree (Vernicia fordii or Vernicia montana).
Chemically, Pure Tung Oil is composed primarily of triglycerides with high levels of unsaturated fatty acids, particularly α-eleostearic acid.
When exposed to air, these unsaturated fatty acids undergo a process called polymerization, forming a durable, water-resistant finish.

CAS Number: 8001-20-5
EC Number: 232-272-4

China wood oil, Nut oil, Tung tree oil, Wood oil, Aleurites oil, Tungseed oil, Oiticica oil, Eucya oil, Kalo oil, Varnish tree oil, Hsiang oil, Lumbang oil, Orelia oil, Thitkado oil, Tung nut oil, Kohayu oil, Pinnay oil, Varnish tree seed oil, Dreschlera triseptata oil, Tracheostoma yedoense oil, Chieh oil, Hokkaung oil, Tung-shu oil, Tung-yu oil, Noog oil, Wood-oil tree oil, Tung-lu oil, Chinese nut oil, Wood-oil oil, Orangewood oil, Tung shu oil, Ta-kai oil, I-chiu oil, Ho-t'ung oil, Hok Pure Tung Oil, Kina-Pure Tung Oil, Kio-oil, Leguminous oil, Nut-oil tree oil, Orelia galactodendron oil, Perilla oil, Tung-shu tree oil, Tung-yu tree oil, Tungtze oil, Lumbang tree oil, Borneo bean oil, Chinezenootolie, Kala oil, Poochay oil, Varnish tree nut oil, Fuegaoil, Kape-mayapis oil, Kalumpang oil, Aleurites oil tree oil, Japan wood oil



APPLICATIONS


Pure Tung Oil finds widespread use as a finish for wooden furniture, providing both protection and enhancing its natural beauty.
Pure Tung Oil is commonly used to seal and protect hardwood floors, offering durability and resistance to foot traffic.

Pure Tung Oil is favored for finishing kitchen countertops and cutting boards due to its food-safe properties.
Wooden decks and outdoor furniture benefit from Pure Tung Oil's ability to withstand weathering and UV exposure.

In the realm of musical instruments, Pure Tung Oil is often used to finish guitar bodies and other wooden components.
Pure Tung Oil serves as a key ingredient in the formulation of varnishes and wood sealers, providing a glossy, protective coat.
Traditional Chinese medicine utilizes Pure Tung Oil for its purported therapeutic properties, such as promoting hair growth and relieving joint pain.

Pure Tung Oil is employed in the production of linoleum, where it acts as a binder for the natural materials.
Pure Tung Oil is used in the creation of handcrafted wooden bowls and utensils, ensuring a safe and durable finish.

Pure Tung Oil is utilized in the restoration and preservation of historical wooden structures and artifacts.
Woodturners and woodworkers apply Pure Tung Oil to lathe-turned projects, enhancing the wood's natural grain patterns.

Pure Tung Oil serves as a base for mixing pigment in oil painting, providing a glossy finish to artwork.
Pure Tung Oil is used to coat outdoor fences and railings, protecting them from moisture and rot.
Boat builders rely on Pure Tung Oil to seal and protect wooden hulls and decks against marine elements.

Pure Tung Oil is applied to wooden toys and children's furniture, ensuring a safe and non-toxic finish.
Pure Tung Oil is used in the manufacturing of high-quality wooden flooring, providing both beauty and durability.
Wood carvers use Pure Tung Oil to finish their creations, accentuating intricate details and textures.
Pure Tung Oil is applied to wooden tool handles to improve grip and protect against wear and tear.

Pure Tung Oil serves as a natural alternative to synthetic wood finishes, appealing to environmentally conscious consumers.
Pure Tung Oil is used in the production of fine cabinetry and woodworking, where its rich finish adds value and elegance.
Artisans apply Pure Tung Oil to decorative wooden objects, such as picture frames and sculptures, for a timeless finish.

Pure Tung Oil is utilized in the construction of outdoor pergolas and trellises, enhancing the wood's natural beauty.
Pure Tung Oil is used in the restoration of antique wooden furniture, reviving its luster and beauty.

Pure Tung Oil serves as a protective coating for exterior wooden siding, maintaining its appearance and integrity.
Pure Tung Oil is applied to wooden doors and windows to protect against moisture infiltration and warping.

Pure Tung Oil is used in the crafting of decorative wooden bowls, plates, and other kitchenware, adding both beauty and functionality.
Woodworkers apply Pure Tung Oil to turned pens and pencils, providing a smooth, durable finish.
Pure Tung Oil is utilized in the construction of outdoor gazebos and pergolas, offering protection against weathering and decay.

Pure Tung Oil serves as a sealant for wooden window frames and sills, prolonging their lifespan and enhancing their appearance.
Pure Tung Oil is used in the manufacturing of fine wooden musical instruments, such as violins and cellos, for its resonance and protective qualities.
Woodcarvers apply Pure Tung Oil to intricate carvings, preserving the wood's natural color and grain while adding depth to the details.
Pure Tung Oil is employed in the restoration of historic wooden ships and boats, ensuring authenticity and longevity.

Pure Tung Oil is used to finish wooden flooring in high-traffic areas such as commercial spaces and public buildings, providing a durable and long-lasting surface.
Pure Tung Oil is applied to outdoor wooden sculptures and art installations, protecting them from the elements while allowing the wood to breathe.

Pure Tung Oil is used in the crafting of traditional Japanese shoji screens and doors, imparting a warm, natural finish.
Pure Tung Oil is applied to wooden picture frames and mirrors, enhancing their appearance and protecting them from damage.
Woodworkers use Pure Tung Oil as a finish for custom-built cabinetry and built-in shelving, ensuring a high-quality, long-lasting result.
Pure Tung Oil is applied to wooden garden furniture and planters, protecting them from moisture and extending their lifespan.

Pure Tung Oil serves as a finish for wooden staircases and handrails, providing both safety and aesthetic appeal.
Pure Tung Oil is used in the production of luxury wooden watches and accessories, adding a touch of sophistication and durability.
Artisans apply Pure Tung Oil to turned bowls and vases, highlighting the natural beauty of the wood grain.
Pure Tung Oil is used in the construction of outdoor wooden structures such as pergolas, arbors, and trellises, providing protection from the elements.

Pure Tung Oil serves as a protective coating for wooden outdoor sculptures and carvings, preserving their beauty for years to come.
Pure Tung Oil is applied to wooden cutting boards and serving trays, providing a safe and durable surface for food preparation and presentation.

Woodworkers use Pure Tung Oil to finish custom-built doors and windows, enhancing their appearance and protecting them from the elements.
Pure Tung Oil is applied to wooden garden sheds and outbuildings, providing protection from moisture and weathering.

Pure Tung Oil is used in the restoration of antique wooden furniture, reviving its beauty and preserving its historical value.
Pure Tung Oil serves as a finish for custom-made wooden furniture, providing a durable and attractive surface.

Woodworkers apply Pure Tung Oil to turned bowls and platters, enhancing the wood's natural beauty and durability.
Pure Tung Oil is used in the crafting of decorative wooden boxes and chests, providing both beauty and protection for treasured items.



DESCRIPTION


Pure Pure Tung Oil, also known as China wood oil, is a drying oil obtained by pressing the seeds of the tung tree (Vernicia fordii or Vernicia montana).
Chemically, Pure Tung Oil is composed primarily of triglycerides with high levels of unsaturated fatty acids, particularly α-eleostearic acid.
When exposed to air, these unsaturated fatty acids undergo a process called polymerization, forming a durable, water-resistant finish.

Pure Pure Tung Oil is often used as a finish for woodwork and as a component in various coatings and paints.
It's valued for its ability to enhance the natural beauty of wood while providing protection against moisture and wear.

Pure Tung Oil, derived from the seeds of the tung tree, boasts a rich history dating back centuries.
Pure Tung Oil possesses a golden-yellow hue, exuding warmth and depth.
Pure Tung Oil is renowned for its remarkable ability to penetrate deep into wood fibers, enhancing its natural grain and color.

When applied, Pure Tung Oil creates a lustrous finish that accentuates the beauty of wood surfaces.
One of its notable qualities is its resistance to water, making it an excellent choice for outdoor furniture and marine applications.

Pure Tung Oil dries to a durable, hard finish, offering protection against scratches, stains, and UV damage.
Unlike some synthetic finishes, Pure Tung Oil maintains the natural look and feel of wood, adding character and charm.

Its versatility extends beyond woodworking, finding applications in varnishes, sealers, and traditional Chinese medicine.
Pure Tung Oil has a distinctive nutty aroma, which diminishes as it cures, leaving behind a faint, pleasant scent.
Craftsmen appreciate Pure Tung Oil for its ease of application, requiring simple techniques such as wiping or brushing.

As a renewable resource, Pure Tung Oil is environmentally friendly, promoting sustainable practices in woodworking and coatings industries.
Pure Tung Oil's low viscosity allows it to flow smoothly, ensuring even coverage and a uniform finish.

With proper care and maintenance, Pure Tung Oil finishes can withstand the test of time, aging gracefully while retaining their beauty.
Its natural drying process eliminates the need for harsh chemicals or additives, reducing environmental impact.

Pure Tung Oil's inherent flexibility allows it to expand and contract with wood, minimizing the risk of cracking or peeling.
When cured, Pure Tung Oil forms a protective barrier that resists moisture, mold, and mildew, ideal for humid climates.

Its non-toxic nature makes Pure Tung Oil a safe choice for interior applications, suitable for furniture, countertops, and wooden toys.
Pure Tung Oil finishes can be easily rejuvenated with periodic maintenance, ensuring lasting beauty and protection.

Artists appreciate Pure Tung Oil as a medium for mixing pigments, creating vibrant colors and textured effects on canvas.
Pure Tung Oil's drying time varies depending on conditions, typically ranging from a few hours to several days for a full cure.
Its high resistance to chemicals and solvents makes Pure Tung Oil an excellent choice for industrial coatings and finishes.

Pure Tung Oil's glossy sheen adds a touch of elegance to any woodworking project, from flooring to cabinetry.
The natural translucency of Pure Tung Oil allows it to enhance the wood's natural characteristics, rather than masking them.

Pure Tung Oil's durability and longevity make it a wise investment for homeowners seeking quality finishes that stand the test of time.
From ancient traditions to modern applications, Pure Tung Oil continues to be valued for its beauty, versatility, and enduring quality.



PROPERTIES


Density: 0.937 g/ml at 25°C
Refractive index (nD): 1.52 (20°C)
Flash point: >110°C
Storage temp.: 2-8°C
Color Gardner: ≤12



FIRST AID


Inhalation:

Move to Fresh Air:
If exposed to Pure Tung Oil fumes or vapors, immediately move the affected person to an area with fresh air.

Seek Medical Attention:
If the person experiences difficulty breathing or shows signs of respiratory distress, seek medical attention promptly.

Provide Oxygen:
If available and trained to do so, administer oxygen to the affected person while awaiting medical assistance.


Skin Contact:

Remove Contaminated Clothing:
If Pure Tung Oil comes into contact with the skin, promptly remove any contaminated clothing.

Wash Skin Thoroughly:
Wash the affected area with soap and water for at least 15 minutes, ensuring thorough rinsing to remove any traces of Pure Tung Oil.

Use Mild Soap:
Use a mild soap or detergent to gently cleanse the skin, avoiding harsh chemicals that may exacerbate irritation.

Apply Moisturizer:
After washing, apply a soothing moisturizer or emollient to the affected area to help soothe and hydrate the skin.

Seek Medical Advice:
If skin irritation persists or worsens, seek medical advice or consult a healthcare professional for further evaluation and treatment.


Eye Contact:

Flush with Water:
Immediately flush the eyes with lukewarm water for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.

Remove Contact Lenses:
If wearing contact lenses, remove them as soon as possible to facilitate irrigation of the eyes.

Seek Medical Attention:
Seek immediate medical attention or contact an eye specialist if irritation, pain, or redness persists after flushing.


Ingestion:

Do Not Induce Vomiting:
Do not induce vomiting if Pure Tung Oil has been ingested, as it may lead to further complications.

Do Not Drink Water:
Refrain from giving anything by mouth to the affected person unless instructed by medical personnel.

Seek Medical Assistance:
Immediately contact a poison control center or seek medical assistance for further guidance and treatment.

Provide Information:
Provide medical personnel with details regarding the amount ingested, the time of ingestion, and any symptoms experienced by the affected person.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and protective clothing, when handling Pure Tung Oil to minimize skin and eye contact.

Ventilation:
Ensure adequate ventilation in the working area to prevent the buildup of vapors.
Use local exhaust ventilation or work in well-ventilated areas to minimize inhalation exposure.

Avoid Contact:
Avoid direct contact with Pure Tung Oil.
In case of skin contact, promptly wash affected areas with soap and water.
In case of eye contact, flush eyes with water for at least 15 minutes and seek medical attention if irritation persists.

Spills and Leaks:
Clean up spills and leaks promptly to prevent accidental exposure.
Absorb small spills with inert absorbent materials such as sand, vermiculite, or clay.
For larger spills, contain the area and dispose of the material according to local regulations.

Preventive Measures:
Implement measures to prevent accidental spills or releases, such as using spill containment trays or secondary containment systems when transferring or storing Pure Tung Oil.


Storage:

Container Selection:
Store Pure Tung Oil in containers made of chemically compatible materials, such as high-density polyethylene (HDPE) or stainless steel, to prevent chemical reactions or degradation of the container.

Sealed Containers:
Ensure that containers of Pure Tung Oil are tightly sealed when not in use to prevent evaporation and contamination.

Temperature Control:
Store Pure Tung Oil in a cool, dry place away from direct sunlight and heat sources.
Avoid exposure to extreme temperatures, as this may affect the quality and stability of the oil.

Incompatible Materials:
Keep Pure Tung Oil away from incompatible materials such as oxidizing agents, acids, and strong bases, as it may react with these substances.

Labeling:
Clearly label containers of Pure Tung Oil with appropriate warning symbols, handling instructions, and safety information to inform users about potential hazards and proper handling procedures.

Separate Storage:
Store Pure Tung Oil away from food, beverages, and animal feed to prevent accidental ingestion or contamination.

Spillage Containment:
Provide spill containment measures, such as spill trays or berms, in storage areas to contain spills and prevent environmental contamination.

Fire Safety:
Pure Tung Oil is combustible and may present a fire hazard.
Store it away from ignition sources, open flames, and heat-producing equipment.
Implement fire prevention measures, such as fire extinguishers and fire suppression systems, in storage areas.

Regulatory Compliance:
Ensure compliance with local regulations and guidelines for the storage of hazardous substances, including Pure Tung Oil.
Familiarize yourself with applicable regulations regarding storage, handling, and disposal.

Training:
Provide training to personnel involved in the handling and storage of Pure Tung Oil on proper procedures, emergency response measures, and the use of personal protective equipment.

DESCRIPTION:
Pureact GLT is a 20% active, naturally derived anionic surfactant produced from L-glutamic acid and lauric acid.
Pureact GLT is a mild surfactant that is non-irritating and readily biodegradable.
Pureact GLT produces moderate to good foam, offers a silky, soft after-feel and is effective at improving the skin mildness in surfactant formulas.

INCI name: Sodium Lauroyl Glutamate

The optimum formulating pH range for Pureact GLT is 4.0 – 10.
Pureact GLT is a COSMOS-approved, anionic surfactant that helps formulators create sustainable personal care products.
The ingredient is 100% naturally derived, readily biodegradable, and free from sulfates, 1,4 dioxane, ethylene oxide and PEG.

Pureact GLT is recommended for mild and gentle body washes, and hand and facial cleaners.
Pureact GLT additionally offers a soft after-feel.

Pureact GLT is the latest innovation to Innospec’s range of sulfate-free, vegetable-based mild surfactants.
This COSMOS approved anionic surfactant helps formulators meet market trends for sustainable personal care products.

Pureact GLT is 100% naturally derived, readily biodegradable, sulfate-free, 1,4 dioxane-free, EO-free and PEG-free.
With Pureact GLT, you can create ultra-mild body washes, hand and facial cleaners that gently cleanse while providing a luxurious experience.


SAFETY INFORMATION ABOUT PUREACT GLT:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

DESCRIPTION:

Pureact LSR is an anionic surfactant used in personal care products as well as in household and industrial applications.
Pureact LSR is naturally derived, sulfate-free and biodegradable.
Pureact LSR is often used as a co-surfactant in cleanser formulations such as shampoos and bodywashes.



CAS NUMBER: 137-16-6

MOLECULAR FORMULA: C15H29NO3.Na

MOLECULAR WEIGHT: 294.39




DESCRIPTION:

Pureact LSR can also be used in oral care applications such as toothpastes and incorporated into syndet and combo bars.
Pureact LSR is sulphate-free, anionic surfactant with 30% active content.
Pureact LSR provides dense lather and aids foam stability.
Pureact LSR can be used in clear formulations and is stable over a wide pH range.

Pureact LSR is an ideal co-surfactant.
Pureact LSR is recommended for use in cosmetics and personal care applications.
Pureact LSR is mild to skin and hair and provides a dense, luxurious lather while leaving behind an elegant after-feel on skin and hair.
Pureact LSR provides foam stability in
formulations, even in the presence of oils and electrolytes.

Pureact LSR is also able to produce a rich, stable lather in the presence of hard water.
Pureact LSR can be used in clear formulations and is stable over a wide pH range, although for best clarity a neutral pH is recommended.
Pureact LSR has excellent compatibility with anionic, nom-ionic and cationic surfactants.
Pureact LSR is also compatible with many conditioning agents which makes it ideal for use in conditioning shampoo formulations.

Pureact LSR is an anionic surfactant raw material in liquid form and has a unique characteristic odour.
Pureact LSR finds use in many cosmetic and detergent products because it is a surfactant that creates foam and has high cleaning power.
Pureact LSR is a white powder derived from sarcosine, which make it is fate-free and biodegradable.
The surfactant is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.

Pureact LSR is personal care products as well as in household and industrial applications.
Pureact LSR is used as a co-surfactant in cleanser formulations such as shampoos and body washes.
Pureact LSR can also be used in oral care applications such as toothpastes and incorporated into syndet and combo bars.
The typical usage levels range from 1-5% on an active basis.

Pureact LSR is mild, biodegradable anionic surfactants derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.
Pureact LSR is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
Pureact LSR is a high foam, eco-friendly surfactant.
Pureact LSR has good chlorine stability with anti-corrosion properties.

Pureact LSR has excellent ocular tolerance and gentleness.
Pureact LSR is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent.
Pureact LSR has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged.
Pureact LSR also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away.
As a modified fatty acid, Pureact LSR is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.




USAGE:

Pureact LSR is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase.
Pureact LSR is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
Pureact LSR has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.
Pureact LSR It inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).


-solubilization and separation of membrane proteins
-lysis of cells during the isolation of RNA
-inhibition of hexokinase



USAGE IN COSMETIC AREA:

-Facial cleansing foam (8.52%)
-Child toothpaste (8.41%)
-Colored/highlighted hair shampoo (7.84%)
-Face cleansing gel (6.11%)
-Classic shampoo (5.89%)



APPLICATION:

-Hair cleansing
-Skin cleansing



PROPERTIES:

-Clear liquid
-80% Naturally derived
-3.0 - 11.0 Formulating pH range




FEATURES:

-Sulfate-free anionic surfactant
-providing dense lather
-aiding foam stability
-used in clear formulations
-stable over a wide pH range
-Ideal co-surfactant.



TYPICAL PROPERTIES:

-Appearance at 25°C: Clear, almost colorless liquid
-Color, APHA (100% as is): 80 maximum
-Activity %: 29-31
-Total Solids, %: 29-35
-pH (10% solution): 7.5-8.5
-Sodium Chloride, %: 0.2 maximum



SPECIFICATIONS:

-pH: 7.0-8.5
-Assay: ≥95.0%
-Appearance: White crystalline powder
-Volatility: ≤5.0%



FUNCTIONS:

-Antistatic: Reduces static electricity by neutralizing the electrical charge on a surface
-Cleaning agent: Helps keep a surface clean
-Emulsifying agent: Promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)
-Foaming agent: Captures small bubbles of air or other gases in a small volume of liquid by changing the surface tension of the liquid
-Hair conditioner: Leaves hair easy to comb, supple, soft and shiny and/or gives volume, lightness and shine
-Skin conditioning agent: Keeps the skin in good condition
-Surfactant: Reduces the surface tension of cosmetics and contributes to the even distribution of the product during use
-Viscosity control agent: Increases or decreases the viscosity of cosmetics



CHEMICAL PROPERTIES:


-Melting point: 46 °C
-density: 1.033 g/mL at 20 °C
-vapor pressure: 0.02 hPa (20 °C)
-RTECS: MC0598960
-Fp: 267℃
-storage temp.: room temp
-solubility: H2O: 1 M at 20 °C, clear, colorless
-form: Powder
-Specific Gravity:1.03 (20/4℃)
-color: White
-Odor: at 100.00?%. bland
-PH: 7.0-9.0 (25℃, 1M in H2O)
-Water Solubility: Soluble in water (293 g/L).
-Sensitive: Hygroscopic



STORAGE:

18-25°C, dry, protect from light, sealed



SYNONYM:

N-Dodecanoylsarcosine Sodium Salt
N-Lauroylsarcosine Sodium Salt
Sodium N-Dodecanoylsarcosinate
Amin LS 30
NPAminosyl L 30As 02-30
Compound 105
Crodasinic LS 30
Crodasinic LS 30NP
N-Methyl-N-(1-oxododecyl)glycine sodium salt (1:1)
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt (1:1)
N-Dodecanoylsarcosine Sodium Salt
Lauroylsarcosine (sodium salt)
NSC-117874
SODIUM N-LAUROYL SARCOSINATE
Sodium N-dodecanoyl-N-methylglycinate
N-Dodecanoyl-N-methylglycine sodium salt
starbld0009501
GARDOL [MI]
MEDIALAN LL-33
N-Lauroylsarcosine-S-salt
Sodium N- lauroylsarcosinate
SCHEMBL23451
C15H29NO3.Na
Lauroylsarcosine, Sodium Salt
DTXCID907066
CHEMBL1903482
C15-H29-N-O3.Na
KSAVQLQVUXSOCR-UHFFFAOYSA-M
SODIUM LAUROYL SARCOSINE 1KG
Tox21_202996
AKOS015901704
SODIUM LAUROYL SARCOSINATE
NCGC00164323-01
NCGC00260541-01
SODIUM LAUROYL SARCOSINATE
AS-81025
CAS-137-16-6
SODIUM LAUROYL SARCOSINATE
sodium;2-[dodecanoyl(methyl)amino]acetate
HY-125920
LS-178955

Purified Isophthalic Acid (PIA) is a type of isophthalic acid that has undergone a purification process to remove impurities.
Isophthalic acid itself is an organic compound with the chemical formula C8H6O4.
Purified isophthalic acid (PIA) is one of the three isomeric benzenedicarboxylic acids, the others being phthalic acid and terephthalic acid.

CAS Number: 121-91-5
EC Number: 204-506-4



APPLICATIONS


Purified isophthalic acid (PIA) is extensively used in the production of unsaturated polyester resins, contributing to the creation of durable and corrosion-resistant composite materials.
Purified isophthalic acid (PIA) plays a crucial role in the manufacturing of fiberglass-reinforced plastics, enhancing the strength and structural integrity of a variety of products.
Purified isophthalic acid (PIA) is a key ingredient in the formulation of coatings, providing enhanced adhesion, chemical resistance, and durability to painted surfaces.

In the automotive industry, PIA is utilized in the production of composite materials for various components, contributing to lightweight and fuel-efficient vehicles.
The high thermal stability of PIA makes it suitable for applications in aerospace engineering, where resistance to extreme temperatures is essential.
Purified isophthalic acid (PIA) is incorporated into the synthesis of specialty copolymers, broadening the range of materials available for specific industrial applications.
In construction materials, purified isophthalic acid contributes to the development of weather-resistant and long-lasting composites used in infrastructure projects.

Purified isophthalic acid (PIA) finds application in the formulation of adhesives, enhancing the bonding strength and chemical resistance of the final adhesive products.
Purified isophthalic acid (PIA) is employed in the creation of advanced materials for the marine industry, where its resistance to water and chemicals is highly beneficial.
In the electrical and electronics sector, Purified isophthalic acid (PIA) contributes to the development of insulating materials with improved thermal and electrical properties.

The versatility of PIA extends to its use in the production of corrosion-resistant tanks, pipes, and other equipment used in chemical processing industries.
Purified isophthalic acid (PIA) is employed in the manufacturing of certain specialty films and laminates, providing enhanced mechanical properties and durability.
Purified isophthalic acid (PIA) is used in the production of corrosion-resistant coatings for industrial equipment, ensuring longevity and reliability in harsh environments.
Purified isophthalic acid (PIA) is incorporated into the synthesis of gel coats, contributing to the smooth finish and weather resistance of surfaces in marine and automotive applications.

The chemical and thermal stability of PIA make it suitable for use in high-performance filters and membranes for industrial separation processes.
In the textile industry, PIA finds application in the production of specialty fibers with improved strength, chemical resistance, and dyeability.
Purified isophthalic acid (PIA) is utilized in the development of specialty foams and insulation materials for construction, providing enhanced thermal performance.

Purified isophthalic acid (PIA) contributes to the creation of composite materials used in sports equipment, such as lightweight and durable components for bicycles and sports gear.
In the production of decorative laminates, Purified isophthalic acid (PIA) enhances the durability and chemical resistance of the final laminated surfaces.
Purified isophthalic acid (PIA) is employed in the formulation of certain resins used in the casting and molding of intricate shapes for artistic and industrial applications.

The automotive aftermarket benefits from PIA in the production of aftermarket body panels and components that require high durability and impact resistance.
Purified isophthalic acid (PIA) is used in the manufacturing of pultruded profiles for construction, contributing to the development of lightweight and corrosion-resistant structural elements.
Purified isophthalic acid (PIA) is incorporated into specialty paints and coatings for architectural applications, providing enhanced protection against environmental factors.

Purified isophthalic acid (PIA) is utilized in the creation of composite materials for renewable energy applications, such as wind turbine components and solar panel structures.
The versatility of PIA continues to drive innovation in material science, contributing to advancements in a wide range of industrial and commercial applications.

Consumer Uses:
Purified isophthalic acid (PIA) is used in the following products:
Adhesives and sealants
Anti-freeze products
Coating products
Lubricants
Greases
Polishes and waxes

Other release to the environment of Purified isophthalic acid (PIA) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Widespread uses by professional workers:

Purified isophthalic acid (PIA) is used in the following products: laboratory chemicals, polymers and coating products.
Purified isophthalic acid (PIA) has an industrial use resulting in manufacture of another substance (use of intermediates).
Purified isophthalic acid (PIA) is used in the following areas: formulation of mixtures and/or re-packaging.
Purified isophthalic acid (PIA) is used for the manufacture of: rubber products and .
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industrial sites:
Purified isophthalic acid (PIA) is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay, adhesives and sealants and inks and toners.
Purified isophthalic acid (PIA) has an industrial use resulting in manufacture of another substance (use of intermediates).
Purified isophthalic acid (PIA) is used in the following areas: formulation of mixtures and/or re-packaging.
Purified isophthalic acid (PIA) is used for the manufacture of: chemicals and plastic products.
Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, manufacturing of the substance, formulation of mixtures and in the production of articles.

Purified isophthalic acid (PIA) is a key component in the production of high-quality gel coats for the surfaces of boats, providing resistance to water, UV radiation, and abrasion.
In the electronics industry, PIA contributes to the formulation of encapsulation materials and coatings, protecting sensitive electronic components from environmental factors.
Purified isophthalic acid (PIA) is utilized in the development of advanced composites for the aerospace industry, enhancing the strength-to-weight ratio of aircraft components.

Purified isophthalic acid (PIA) is incorporated into the production of specialty laminates for printed circuit boards, ensuring reliable insulation and protection.
In the automotive sector, PIA is employed in the creation of body panels, ensuring a balance of lightweight construction and structural integrity.
The chemical resistance of PIA makes it a suitable candidate for the formulation of corrosion-resistant linings for tanks and pipelines in the chemical processing industry.

Purified isophthalic acid (PIA) is used in the manufacturing of certain adhesives and sealants, providing enhanced bonding properties and resistance to environmental conditions.
Purified isophthalic acid (PIA) contributes to the development of specialty resins for 3D printing applications, where high-performance materials are required.
Purified isophthalic acid (PIA) finds application in the creation of composite materials for medical devices, ensuring biocompatibility and resistance to sterilization processes.

In the renewable energy sector, PIA is used in the production of composite materials for the blades of wind turbines, contributing to their durability and performance.
Purified isophthalic acid (PIA) is incorporated into the synthesis of specialty films used in the packaging industry, providing a combination of strength and flexibility.
Purified isophthalic acid (PIA) is employed in the formulation of corrosion-resistant coatings for steel structures in marine environments, extending their service life.

Purified isophthalic acid (PIA) plays a role in the production of specialty resins for the casting of intricate and detailed components in the arts and crafts industry.
In the medical field, Purified isophthalic acid (PIA) contributes to the development of materials for medical implants, ensuring compatibility with the human body.

Purified isophthalic acid (PIA) is utilized in the creation of specialty adhesives for the bonding of composite materials in the manufacturing of sports equipment.
The high-performance properties of PIA make it suitable for use in the production of lightweight components for the automotive racing industry.
In the construction sector, Purified isophthalic acid (PIA) is incorporated into the formulation of durable and weather-resistant coatings for architectural structures.

Purified isophthalic acid (PIA) contributes to the development of composite materials for the construction of lightweight and energy-efficient aircraft interiors.
Purified isophthalic acid (PIA) is used in the formulation of specialty resins for the production of chemical-resistant industrial flooring materials.

Purified isophthalic acid (PIA) is applied in the creation of specialty foams for insulation purposes, providing a balance of thermal performance and durability.
In the oil and gas industry, PIA is used in the formulation of coatings for offshore structures, providing protection against harsh marine conditions.
Purified isophthalic acid (PIA) is employed in the production of specialty adhesives for the assembly of electronic devices, ensuring reliable performance in challenging environments.

The high-purity characteristics of PIA make it suitable for the formulation of materials used in the semiconductor manufacturing process.
Purified isophthalic acid (PIA) is utilized in the creation of specialty resins for the casting and molding of architectural elements with intricate designs.
Purified isophthalic acid (PIA) contributes to the development of advanced materials for military applications, where strength, durability, and lightweight properties are crucial.

Purified isophthalic acid (PIA) is an essential component in the production of composite materials used in the construction of lightweight and high-strength sporting goods, such as tennis rackets and golf club components.
Purified isophthalic acid (PIA) contributes to the development of specialty adhesives for bonding materials in the aerospace industry, ensuring structural integrity and resistance to extreme conditions.
In the field of automotive manufacturing, PIA finds application in the production of durable and lightweight components, including body panels, interior parts, and structural elements.
Purified isophthalic acid (PIA) is utilized in the formulation of corrosion-resistant coatings for industrial equipment, protecting against harsh chemicals and environmental exposure.
Purified isophthalic acid (PIA) plays a role in the creation of specialized resins for the encapsulation of electronic components, providing insulation and protection against moisture and contaminants.

The chemical resistance of PIA makes it suitable for use in the formulation of specialty coatings for kitchenware and appliances, ensuring longevity and easy cleaning.
Purified isophthalic acid (PIA) is employed in the production of high-performance membranes for gas separation applications, contributing to the efficiency of separation processes in various industries.
Purified isophthalic acid (PIA) is used in the formulation of specialty inks for printing on flexible packaging materials, providing adhesion and durability.

In the manufacturing of advanced materials for military and defense applications, PIA contributes to the development of lightweight and resilient components for vehicles and equipment.
Purified isophthalic acid (PIA) is incorporated into the synthesis of specialty resins used in the creation of high-quality laminates for architectural surfaces, offering durability and aesthetic appeal.
Purified isophthalic acid (PIA) is utilized in the formulation of specialty paints for outdoor applications, contributing to the protection and longevity of structures such as bridges and pipelines.

Purified isophthalic acid (PIA) plays a role in the production of specialty foams used in the automotive and construction industries, providing insulation and impact resistance.
In the renewable energy sector, PIA is employed in the formulation of materials used in the construction of solar panel components, ensuring durability and performance.
The high thermal stability of PIA makes it suitable for use in the manufacturing of components for electrical and electronic devices that require resistance to heat.

Purified isophthalic acid (PIA) contributes to the creation of corrosion-resistant linings for tanks and vessels used in the storage and transportation of aggressive chemicals.
Purified isophthalic acid (PIA) is used in the formulation of specialty resins for the casting and molding of artistic sculptures and intricate architectural details.
In the production of specialty films for medical packaging, PIA provides a combination of barrier properties and flexibility.
Purified isophthalic acid (PIA) is incorporated into the synthesis of specialty adhesives used in the assembly of medical devices, ensuring biocompatibility and reliability.

The versatility of PIA extends to the creation of composite materials for marine applications, providing resistance to saltwater and harsh marine conditions.
Purified isophthalic acid (PIA) is employed in the formulation of specialty coatings for industrial equipment used in the food and beverage processing industry, ensuring compliance with hygiene standards.
Purified isophthalic acid (PIA) contributes to the development of advanced materials for the construction of lightweight and durable components in the automotive racing industry.
Purified isophthalic acid (PIA) is utilized in the production of specialty resins for the formulation of corrosion-resistant coatings for infrastructure in coastal environments.

In the development of specialty fibers for technical textiles, PIA enhances the strength and chemical resistance of the final textile products.
Purified isophthalic acid (PIA) is incorporated into the synthesis of specialty adhesives used in the bonding of composite materials for the production of wind turbine blades.
The high-purity characteristics of Purified isophthalic acid (PIA) make it a reliable choice in the manufacturing of high-performance materials used in critical applications across various industries.



DESCRIPTION


Purified Isophthalic Acid (PIA) is a type of isophthalic acid that has undergone a purification process to remove impurities.
Isophthalic acid itself is an organic compound with the chemical formula C8H6O4.
Purified isophthalic acid (PIA) is one of the three isomeric benzenedicarboxylic acids, the others being phthalic acid and terephthalic acid.

In purified isophthalic acid (PIA), the substance is refined to meet specific quality and purity standards, making it suitable for various industrial applications.
The purification process typically involves the removal of impurities such as colorants and other contaminants to produce a high-quality product.

Purified isophthalic acid (PIA) is commonly used in the production of resins, polymers, and fibers.
Purified isophthalic acid (PIA) is a key raw material in the manufacturing of certain types of polyesters, including unsaturated polyester resins, which find applications in the production of fiberglass-reinforced plastics, coatings, and other composite materials.
The high purity of Purified isophthalic acid (PIA) is desirable in these applications to ensure the performance and properties of the final products.

Purified isophthalic acid (PIA) is a high-quality organic compound known for its role in the production of specialty polymers.
With a molecular formula of C8H6O4, Purified isophthalic acid (PIA) belongs to the family of aromatic dicarboxylic acids.
Purified isophthalic acid (PIA) is a purified form of isophthalic acid, ensuring a high level of purity and minimal impurities.
Purified isophthalic acid (PIA) is characterized by its white crystalline appearance, reflecting its refined and purified nature.

The chemical structure of PIA consists of two carboxylic acid groups attached to a benzene ring, contributing to its versatility in polymer synthesis.
Known for its high thermal stability, purified isophthalic acid is often used in applications requiring resistance to heat and temperature fluctuations.
Purified isophthalic acid (PIA) is a key raw material in the production of unsaturated polyester resins, contributing to the development of durable and corrosion-resistant composite materials.

Purified isophthalic acid (PIA) plays a crucial role in the synthesis of certain polyesters, where its high purity is essential for achieving desired material properties.
Purified isophthalic acid (PIA) is utilized in the manufacturing of fiberglass-reinforced plastics, contributing to the strength and resilience of the final composite products.
With its excellent chemical resistance, Purified isophthalic acid (PIA) is favored in applications where exposure to various chemicals is a concern.

The refined nature of Purified isophthalic acid (PIA) makes it suitable for use in coatings, adhesives, and other applications where purity and performance are paramount.
The high-quality synthesis of Purified isophthalic acid (PIA) ensures minimal coloration, making it ideal for applications where color consistency is crucial.

As a specialty chemical, Purified isophthalic acid (PIA) finds applications in industries such as aerospace, automotive, and construction, contributing to the development of advanced materials.
Purified isophthalic acid exhibits good solubility in certain solvents, facilitating its incorporation into various formulations during material production.
Purified isophthalic acid (PIA) is known for its compatibility with other resins and additives, allowing for the formulation of customized materials with specific properties.

Purified isophthalic acid (PIA)'s versatility extends to its use as a building block in the synthesis of specialty copolymers and blends, enhancing the range of available materials.
Due to its high melting point and stability, purified isophthalic acid contributes to the dimensional stability of final polymer products.
Purified isophthalic acid (PIA)'s low volatility makes it suitable for processing at elevated temperatures without significant loss of the compound during production.
Purified isophthalic acid (PIA)'s chemical structure imparts it with a degree of rigidity, contributing to the structural integrity of polymers in which it is incorporated.

In the realm of advanced materials, purified isophthalic acid plays a crucial role in the development of lightweight and high-performance composite structures.
Its incorporation into polymeric matrices enhances the resistance of materials to environmental factors such as moisture and UV radiation.
Purified isophthalic acid (PIA) is valued for its contribution to the improvement of material properties, including mechanical strength, chemical resistance, and durability.
The refined nature of PIA ensures that it meets stringent quality standards, making it a reliable choice for critical applications in various industries.

Due to its controlled synthesis and purification processes, Purified isophthalic acid (PIA) is a consistent and dependable component in the manufacturing of specialized polymers.
As a key ingredient in the synthesis of high-performance materials, Purified isophthalic acid (PIA) continues to contribute to advancements in material science and engineering.



PROPERTIES


Chemical Formula: C8H6O4
Molecular Weight: Approximately 166.13 g/mol
Appearance: White crystalline powder
Odor: Odorless
Melting Point: Varies based on the specific grade, typically within the range of 222-235°C (432-455°F)
Boiling Point: Decomposes before boiling
Density: Varies, typically around 1.52 g/cm³
Solubility in Water: Low solubility, sparingly soluble in cold water
Solubility in Organic Solvents: Soluble in various organic solvents, including acetone and methanol
pH (1% Solution): Typically acidic
Purity: High purity due to the purification process
Hygroscopicity: Low to moderate (ability to absorb moisture from the air)
Stability: Stable under normal storage conditions
Flash Point: Not applicable (solid at room temperature)
Vapor Pressure: Negligible
Vapor Density: Not applicable (solid at room temperature)
Partition Coefficient (Log Kow): Estimated to be low due to its hydrophilic nature
Reactivity: Generally non-reactive under normal conditions
Corrosivity: Non-corrosive to metals under normal conditions
Toxicity: Low toxicity; however, ingestion or inhalation should be avoided
Flammability: Non-flammable
Autoignition Temperature: Not applicable
Decomposition Temperature: Decomposes at elevated temperatures
Biodegradability: Not readily biodegradable



FIRST AID


Inhalation:

Move to Fresh Air:
If inhaled, promptly remove the affected person to an area with fresh air.

Seek Medical Attention:
If respiratory irritation or difficulty persists, seek immediate medical attention.

Provide Artificial Respiration:
If breathing has stopped, provide artificial respiration.


Skin Contact:

Remove Contaminated Clothing:
Quickly and gently remove contaminated clothing.

Wash Skin:
Wash the affected area with plenty of water for at least 15 minutes, using a mild soap if available.

Seek Medical Attention:
If irritation, redness, or signs of chemical burns occur, seek medical attention.


Eye Contact:

Flush Eyes:
Immediately flush the eyes with gently flowing water for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.

Seek Medical Attention:
If irritation, redness, or visual disturbances persist, seek immediate medical attention.


Ingestion:

Do Not Induce Vomiting:
Do not induce vomiting unless directed to do so by medical personnel.

Rinse Mouth:
Rinse the mouth with water.

Seek Medical Attention:
Seek immediate medical attention.
Provide the SDS or product label to healthcare professionals.


General First Aid Measures:

Personal Protection:
Wear appropriate personal protective equipment (PPE) when administering first aid.

Medical Attention:
If there is any doubt about the severity of exposure or symptoms, seek medical attention promptly.

Transport to Medical Facility:
If necessary, transport the affected person to a medical facility for further evaluation and treatment.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles or a face shield, protective clothing, and, if necessary, respiratory protection.
Consider the use of impervious aprons or clothing to prevent skin contact.

Ventilation:
Work in a well-ventilated area or use local exhaust ventilation to control airborne concentrations.
Ensure that mechanical ventilation systems are properly maintained and functioning.

Avoidance of Contact:
Minimize skin contact by wearing appropriate clothing and PPE.
Avoid inhalation of vapors or mists.
Use respiratory protection if necessary.

Preventive Measures:
Implement good industrial hygiene practices, including regular hand washing and avoiding touching the face, mouth, or eyes.
Establish and follow proper procedures for handling, transfer, and disposal.

Handling Equipment:
Use equipment made of materials compatible with purified isophthalic acid.
Ensure that containers and transfer equipment are properly labeled and free from contaminants.

Spill and Leak Response:
Have spill response measures in place, including absorbent materials, spill kits, and appropriate personal protective equipment.
Immediately contain and clean up spills to prevent environmental contamination.

Avoid Mixing Incompatibles:
Avoid mixing PIA with incompatible substances.
Refer to the SDS for information on incompatible materials.


Storage:

Storage Conditions:
Store purified isophthalic acid in a cool, dry, and well-ventilated area.
Keep away from sources of heat, sparks, open flames, and incompatible materials.

Temperature Control:
Store in a temperature-controlled environment, and avoid exposure to extreme temperatures.
Follow any specific temperature requirements provided by the manufacturer.

Container Compatibility:
Use containers made of materials compatible with PIA, such as high-density polyethylene (HDPE) or glass.
Ensure that containers are properly sealed and labeled with the necessary hazard information.

Segregation:
Segregate PIA from incompatible substances as per safety guidelines.
Clearly mark storage areas and containers to avoid confusion.

Avoid Direct Sunlight:
Keep containers shielded from direct sunlight to prevent degradation of the substance.

Fire Prevention:
Store away from oxidizing agents and combustible materials.
Implement fire prevention measures in the storage area, including the availability of fire extinguishing equipment.

Handling Precautions:
Store away from food and beverages.
Clearly mark storage areas with appropriate warning signs.

Regular Inspections:
Conduct regular inspections of storage areas for signs of damage, leaks, or deteriorating conditions.
Promptly address any issues identified during inspections.



SYNONYMS


1,3-Benzenedicarboxylic acid
o-Phthalic acid
Benzene-1,3-dicarboxylic acid
m-Phthalic acid
Isophthalic acid
Benzene-1,3-dicarboxylate
o-Carboxybenzene-1,3-dicarboxylic acid
3-Carboxybenzoic acid
meta-Phthalic acid
Benzene-1,3-dioic acid
m-Benzenedicarboxylic acid
Benzene-1,3-dicarboxylic acid
m-Benzene-1,3-dicarboxylic acid
m-Dicarboxybenzene
meta-Phthalic acid
3-Carboxybenzoic acid
1,3-Benzenedicarboxylic acid
o-Phthalic acid
Isophthalic acid
m-Benzenedicarboxylic acid
1,3-Dicarboxybenzene
Benzene-1,3-dioic acid
3-Carboxybenzene-1,3-dicarboxylic acid
Isophthalic acid, purified
Benzene-1,3-dicarboxylate
meta-Dicarboxybenzene
m-Phthalic acid
Benzene-1,3-dicarboxylic acid, purified
m-Carboxybenzene-1,3-dicarboxylic acid
Isophthalic acid, high purity
Benzene-1,3-dicarboxylic acid, pure
Isophthalic acid, technical grade
meta-Benzenedicarboxylic acid
1,3-Benzenedicarboxylate
Benzene-1,3-dicarboxylic acid, ultra-pure
High-purity isophthalic acid

4-Methylbenzenesulfonic acid monohydrate; Toluol-4-sulfonsäure; ácido tolueno-4-sulfónico; Acide toluène-4-sulfonique; p-tsa monohydrate; Methylbenzenesulfonic acid monohydrate; PTSA monohydrate; Toluenesulfonic acid monohydrate; Tosic acid monohydrate; cas no : 6192-52-5

PVA 1788 is a synthetic polymer derived from vinyl acetate through a polymerization process.
PVA 1788 refers to a specific grade of polyvinyl alcohol, and it is characterized by its molecular weight and other properties.
PVA 1788 is water-soluble and can be used in various applications due to its film-forming, adhesive, and emulsifying properties.



APPLICATIONS


PVA 1788 is widely used as a binder in the production of water-soluble packaging films, making it a sustainable choice for single-use applications.
Its film-forming properties find a crucial role in the manufacturing of adhesives, including paper adhesives and wood glues.

In the textile industry, PVA 1788 is employed as a sizing agent to improve fiber strength and facilitate smoother weaving processes.
Coatings with PVA 1788 contribute to enhancing the surface properties of paper, making it more suitable for printing and writing.
PVA 1788 serves as an emulsifying agent, stabilizing emulsions and suspensions in various industries such as cosmetics and food.

PVA 1788 is used in ceramics to enhance the green strength of clay bodies, ensuring better shape retention during forming.
PVA-based coatings and films, containing PVA 1788, are utilized in photography as binders for photographic emulsions, contributing to image stability.

PVA 1788's water-solubility makes it a valuable ingredient in water-based personal care products like shampoos and conditioners.
PVA 1788 's compatibility with various materials makes PVA 1788 a suitable candidate for creating composite materials with enhanced properties.

PVA 1788 acts as a release agent in mold-making and casting processes, preventing adhesion to molds and ensuring easy removal.
In the pharmaceutical industry, PVA 1788 is used as a binding agent in tablet formulations to hold the active ingredients together.
Its adhesion and film-forming properties are utilized in the production of adhesive labels, stickers, and tapes.

PVA-based coatings with PVA 1788 are applied to textiles to improve their strength, durability, and resistance to moisture.
The polymer, PVA 1788, is employed in the production of water-soluble pouches containing detergent or cleaning products for convenient and eco-friendly use.
Solutions containing PVA 1788 are used as coatings for paper and cardboard packaging materials, providing a protective layer and enhancing printability.

PVA 1788 acts as a binder in the production of ceramic components, ensuring structural integrity during firing.
In the construction industry, formulations containing PVA 1788 are used in paints and coatings, enhancing adhesion to various surfaces.

PVA 1788's water-soluble properties make it useful in the creation of temporary support structures, such as water-soluble scaffolds in tissue engineering.
The polymer, PVA 1788, finds application in the creation of artificial snow and snow effects in theatrical and film productions.
In the cosmetic industry, PVA 1788 is employed in the formulation of wound dressings and medical devices due to its biocompatibility and water-absorbing capabilities.
PVA 1788 contributes to the production of biodegradable packaging materials, reducing the environmental impact of disposable products.

PVA-based gels containing PVA 1788 are used in various industries, including cosmetics and food, for their gelling and stabilizing properties.
The polymer, PVA 1788, serves as a protective coating for fragile items during shipping and storage, preventing damage.

In food applications, PVA 1788 is used to encapsulate flavors, vitamins, and other active ingredients for controlled release.
The versatile applications of PVA 1788 span industries such as textiles, pharmaceuticals, packaging, cosmetics, and more, showcasing its adaptability and value in modern manufacturing and technology.
PVA 1788 is used in the production of water-soluble films for laundry detergent pods, offering convenient and mess-free usage.
Its adhesive properties make PVA 1788 suitable for manufacturing envelopes and stamps, ensuring secure sealing.
PVA-based coatings with PVA 1788 are applied to fabrics to create stiffened shapes for crafts and decorations.

In the beauty industry, PVA 1788 is used in the formulation of peelable face masks, aiding in deep cleansing and exfoliation.
In the agricultural sector, films containing PVA 1788 are employed as biodegradable mulching materials to enhance crop growth.

The polymer, PVA 1788, acts as a binder in the creation of ceramic glazes, contributing to the aesthetics and protection of pottery.
PVA 1788 solutions are utilized as a sizing agent in the production of fibers for woven and non-woven textiles.

In the manufacture of artificial flowers, adhesives containing PVA 1788 ensure the secure attachment of petals and components.
PVA 1788 films find applications in the textile and apparel industry for creating water-soluble embroidery backings.
PVA 1788 is used as a component in hydrogel dressings for wound care due to its absorbent and soothing properties.

Films containing PVA 1788 are utilized as temporary barriers in construction, protecting surfaces from overspray and damage.
In the food industry, PVA 1788 is employed to coat fruits and vegetables, extending their shelf life and maintaining freshness.
PVA 1788 acts as a binder in the creation of casting slips for ceramics, ensuring uniformity and ease of molding.
Solutions containing PVA 1788 are used to protect sensitive surfaces during paint spraying and finishing operations in the automotive industry.
The polymer, PVA 1788, serves as a dispersing agent in the production of paint and ink pigments, ensuring even color distribution.

In the creation of artificial snow for holiday decorations and winter scenes, PVA 1788's texture mimics real snow.
PVA 1788 is used in the formulation of polymer electrolyte membranes for fuel cells, aiding in energy conversion.
It is utilized in the creation of water-soluble packaging materials for agricultural chemicals and detergents.

PVA 1788 is employed as a lubricating and binding agent in the production of graphite-based lubricants.
The polymer, PVA 1788, is used in the textile industry to enhance fabric drape and hand, making it more comfortable to wear.
PVA-based adhesives containing PVA 1788 are used in the assembly of paperboard packaging, ensuring strong bonds and structural integrity.

In the creation of papier-mâché crafts, PVA 1788 is used as a binder to hold paper layers together.
PVA 1788 films are employed in the production of dissolvable laundry bags for hospitals and hotels, simplifying linen management.
PVA 1788 acts as a barrier coating in packaging materials to prevent oxygen and moisture from degrading contents.
The versatile applications of PVA 1788 extend across industries, including agriculture, construction, cosmetics, textiles, and more, making it an essential polymer with diverse and innovative uses.

PVA 1788 is used in the formulation of water-based inkjet printing inks, ensuring vibrant and durable color on various substrates.
PVA 1788 is employed in the creation of biodegradable seed tapes, facilitating precise and efficient planting in agriculture.
PVA-based hydrogels containing PVA 1788 are used in controlled drug delivery systems, gradually releasing medication for therapeutic purposes.
In the production of water-soluble films for dishwasher and laundry detergent pods, PVA 1788 ensures convenient and effective cleaning.
PVA 1788 is used to create flexible and transparent membranes in fuel cells, enhancing the efficiency of energy conversion.

Films containing PVA 1788 are utilized in the packaging of water-soluble fertilizers, providing easy and accurate dosing for agricultural applications.
The polymer, PVA 1788, is employed in the formulation of water-soluble binders for ceramics, facilitating precise shaping and firing.
PVA 1788 coatings are applied to concrete surfaces to provide a temporary moisture barrier during curing.
In the creation of biodegradable sutures, PVA 1788 contributes to wound closure and tissue healing in medical procedures.
The versatile applications of PVA 1788 reflect its adaptability and contribution to eco-friendly solutions across industries, making it a versatile and valuable polymer.

PVA 1788 is used in the formulation of water-based paints and coatings, contributing to improved adhesion and durability on various surfaces.
PVA 1788 finds application in the creation of water-soluble pouches containing cleaning agents, offering convenience and reducing waste.
PVA-based hydrogels containing PVA 1788 are utilized in wound dressings and medical bandages, providing a moist environment for healing.

In the automotive industry, solutions containing PVA 1788 are used as mold release agents, preventing adhesion in composite manufacturing.
PVA 1788 coatings are applied to fruits to create a protective layer, extending their shelf life and preserving quality during transportation.
The polymer, PVA 1788, is employed in the formulation of biodegradable detergent capsules, ensuring accurate dosing and reducing packaging waste.

PVA 1788's solubility in water is utilized in the creation of biodegradable seedling pots, promoting sustainable gardening practices.
In the creation of artificial tears and lubricating eye drops, PVA 1788 provides comfort and relief to individuals with dry eyes.

PVA 1788 is used in the formulation of water-soluble barrier coatings for concrete surfaces, protecting them during curing.
PVA 1788 finds application in the assembly of paper-based packaging materials, ensuring secure and reliable closures.
PVA-based adhesives containing PVA 1788 are employed in the construction of paperboard boxes and cartons, enhancing packaging integrity.
Films containing PVA 1788 are used in the production of biodegradable tea bags, offering an eco-friendly alternative to conventional tea packaging.

In the electronics industry, solutions containing PVA 1788 are used as temporary encapsulants in soldering processes, protecting components.
PVA 1788's water-soluble packaging films are used in the creation of single-use medical devices and diagnostic tests.
The polymer, PVA 1788, is employed in the formulation of water-based screen printing inks, suitable for various textiles and substrates.
PVA 1788 is used in the creation of biodegradable fishing lines and nets, reducing plastic waste in aquatic environments.
In the food industry, PVA 1788 coatings are applied to candies and confections, enhancing appearance and shelf life.

PVA-based gels containing PVA 1788 are utilized in horticulture as plant growth regulators, promoting healthy root development.
PVA 1788 is employed in the formulation of biodegradable dishwashing detergent capsules, minimizing environmental impact.
The polymer, PVA 1788, serves as a binder in the production of water-soluble ceramic molds for precision casting applications.
Films containing PVA 1788 are used in the production of dissolvable packaging materials for detergents and cleaning products.
PVA 1788 finds application in the creation of biodegradable agricultural mulch films, improving soil conditions and crop yield.

PVA 1788 coatings are used to create temporary barriers in construction, protecting surfaces from debris and damage.
In the creation of biodegradable single-use cutlery and utensils, PVA 1788 contributes to sustainable alternatives.
The numerous applications of PVA 1788 highlight its adaptability and contribution to eco-friendly solutions across industries, making it a versatile and valuable polymer.



DESCRIPTION


PVA 1788 is a synthetic polymer derived from vinyl acetate through a polymerization process.
PVA 1788 refers to a specific grade of polyvinyl alcohol, and it is characterized by its molecular weight and other properties.
PVA 1788 is water-soluble and can be used in various applications due to its film-forming, adhesive, and emulsifying properties.

PVA 1788 is a synthetic polymer derived from vinyl acetate through polymerization.
PVA 1788 is renowned for its water-solubility, forming viscous solutions when dissolved in water.
PVA 1788 exhibits film-forming properties, making it valuable in various applications.

PVA 1788 is available in different grades, with PVA 1788 referring to a specific molecular weight.
PVA 1788 finds extensive use in adhesives, including wood glues and paper adhesives.
As a textile sizing agent, it enhances the weaving process and boosts fiber strength.

In paper coatings, PVA 1788 improves surface characteristics and enhances printability.
Its emulsifying properties make it an effective component in emulsions and suspensions.
PVA 1788 is employed in water-soluble packaging films for single-use applications.

The film-forming nature of PVA finds a niche in personal care products like shampoos.
PVA solutions act as release agents in mold-making and casting processes.
Pharmaceutical industries use PVA as a binding agent in tablet formulations.
PVA 1788 plays a vital role in ceramics by enhancing green strength prior to firing.

In photography, PVA solutions serve as coatings and binders for photographic emulsions.
PVA 1788 is known for its versatility across industries due to its unique properties.
Its solubility in water allows for easy application and removal in various processes.

PVA 1788 contributes to improved adhesion and cohesion in adhesive formulations.
Its effectiveness as a textile sizing agent enhances the efficiency of weaving operations.
PVA 1788 's emulsifying properties aid in stabilizing suspensions and ensuring even dispersion.
In pharmaceuticals, PVA's binding properties help maintain the integrity of tablet formulations.
Its role in ceramics helps create strong and durable structures during firing.

PVA 1788 's water-soluble packaging films find applications in eco-friendly and convenient packaging solutions.
As a film-forming agent in personal care products, it adds a protective layer to hair strands.
PVA 1788 's compatibility with various materials makes it an essential ingredient in a wide range of products.
The unique combination of properties in PVA 1788 makes it a versatile polymer with applications spanning multiple industries.



PROPERTIES

Physical Properties:

State: Typically exists as a white to cream-colored powder, granules, or flakes.
Solubility: Water-soluble, forming viscous solutions when dissolved in water.
Odor: Generally odorless.
Density: The density can vary based on the grade and molecular weight of PVA.

Chemical Properties:

Chemical Formula: (C2H4O)n (represents the repeating unit of PVA polymer).
Hydrophilicity: Highly hydrophilic due to the presence of hydroxyl groups.
Chemical Reactivity: PVA is relatively inert and does not react with most common chemicals under normal conditions.
Degradability: PVA is biodegradable under certain conditions, especially in aerobic environments.

Mechanical Properties:

Flexibility: PVA films and coatings can be flexible and conform to various surfaces.
Strength: The mechanical strength of PVA can vary based on the grade and molecular weight.

Thermal Properties:

Melting Point: PVA does not have a distinct melting point, but it decomposes upon heating.
Thermal Stability: PVA starts to degrade at elevated temperatures, with decomposition starting around 200°C (392°F).



FIRST AID


Inhalation:

If inhaled and respiratory irritation occurs, move the affected person to fresh air.
If breathing difficulties persist, seek medical attention.


Skin Contact:

In case of skin contact, remove contaminated clothing and wash the affected skin with plenty of water and mild soap.
If irritation or redness occurs, seek medical advice.
Avoid using solvents or harsh chemicals to remove PVA from the skin.


Eye Contact:

Immediately flush the eyes with plenty of water for at least 15 minutes, holding the eyelids open.
Seek medical attention if irritation, redness, or discomfort persists.
Remove contact lenses if easily removable after flushing.


Ingestion:

If accidentally ingested, do not induce vomiting unless directed to do so by medical professionals.
Rinse the mouth and drink plenty of water to dilute the substance.
Seek immediate medical attention and provide medical personnel with relevant information about the ingested substance.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including chemical-resistant gloves, safety goggles, and protective clothing, when handling PVA to minimize skin and eye contact.

Ventilation:
Use PVA 1788 in a well-ventilated area to prevent the buildup of dust or vapors.
Consider using local exhaust ventilation to capture and remove any airborne particles.

Avoid Ingestion:
Never eat, drink, or smoke while handling PVA to prevent accidental ingestion.

Prevent Inhalation:
Avoid breathing in dust or vapors by using a dust mask or respirator if necessary, especially when working with powdered forms of PVA.

Spill Management:
In case of spills, contain and clean up PVA using appropriate methods, such as sweeping up dry material or wiping up with absorbent material.
Dispose of waste according to local regulations.

Avoid High Temperatures:
Store PVA 1788 away from heat sources, open flames, and direct sunlight, as exposure to high temperatures can lead to degradation or melting.

Prevent Static Buildup:
PVA 1788 can generate static electricity, so use appropriate precautions to prevent static discharge when handling the material.
Storage:

Storage Area:
Store PVA in a cool, dry, well-ventilated area away from incompatible materials, strong oxidizing agents, and sources of ignition.

Temperature:
Keep PVA 1788 at room temperature or below to maintain its stability and prevent thermal degradation.

Container:
Store PVA 1788 in tightly sealed containers to prevent moisture absorption, which can affect its water-solubility and properties.

Separation:
Store PVA 1788 away from chemicals that may react with it, as well as substances that could contaminate it.

Original Packaging:
Whenever possible, store PVA 1788 in its original packaging, which is often designed to protect it from environmental factors.

Avoid Humidity:
PVA 1788 is hygroscopic and can absorb moisture from the air. Store in a dry environment or use desiccants to maintain product integrity.

Handling of Bags/Containers:
When handling bags or containers of PVA, ensure proper lifting techniques to avoid strain or injury.



SYNONYMS


PVOH (Abbreviation for PolyVinyl Alcohol)
PVAL (Abbreviation for PolyVinyl Alcohol)
PVA Resin
PVO
Vinol
Alcotex
Polyethenol
Alcoholysis Resin
Vinylon
Vinol Fiber
Polyviol
Gohsenol
Kollicoat
Elvanol
Alcotex
Airvol
Kuralon
Alcotex
Mowiol
Gelvatol
Lurex
Kuraray
Gelvatol
Mowiol
Vinacol
Polyvinyl Hydrate
Ethanol Homopolymer
Poval
Vinylon
Povinal
Poval Resin
Ethylene Polymer
Ethenol Polymer
Alkoxol
Poval Polymer
Ethenol Homopolymer
Ethylene Alcohol Polymer
PVA Polymer
Ethenol Resin
Polyvinyl Polyol
Vinyl Alcohol Polymer
PVAL Resin
Ethenol Polymer
Alkoxol Resin
Vinol Resin
Ethenol Polymeric Compound
Vinyl Alcohol Homopolymer
Ethanol Vinyl Polymer
PVAL Polymer
Ethenol Polymer Compound
Alcotex
Hydroxyethylene Polymer
Alcoholysis Resin
Hydroxyethene Polymer
Poly(1-hydroxyethylene)
Hydroxyethyl Polymer
Polyvinyl Ether
Vinovyl Polymer
Alkoxol Polymer
Ethylene Alcohol Homopolymer
Hydroxyethylene Homopolymer
Poly(vinyl alcohol)
Hydroxyethene Homopolymer
Polyvinyl Alcohol Resin
Ethylene Polymer Alcohol
Vinylon Fiber
PVA Copolymer
Hydroxyethyl Resin
Vinyl Alcohol Homopolymer
Ethylene Vinyl Alcohol Polymer
Hydroxyethene Polymer Compound
Ethanol Vinyl Polymer
Ethenol Homopolymer Compound
PVA Compound
Hydroxyethylene Polymer Resin

PVM/MA COPOLYMER, N° CAS : 9011-16-9, Nom INCI : PVM/MA COPOLYMER. Classification : Polymère de synthèse. Ses fonctions (INCI): Antistatique : Réduit l'électricité statique en neutralisant la charge électrique sur une surface. Agent fixant : Permet la cohésion de différents ingrédients cosmétiques. Stabilisateur d'émulsion : Favorise le processus d'émulsification et améliore la stabilité et la durée de conservation de l'émulsion. Agent filmogène : Produit un film continu sur la peau, les cheveux ou les ongles. Agent de fixation capillaire : Permet de contrôler le style du cheveu. Agent de contrôle de la viscosité : Augmente ou diminue la viscosité des cosmétiques. Noms français : 2,5-FURANDIONE, POLYMER WITH METHOXYETHENE; POLYMERE DU METHOXYETHENE ET DU FURANNE-2,5-DIONE. Noms anglais : MALEIC ANHYDRIDE, POLYMER WITH METHYL VINYL ETHER; METHYL VINYL ETHER-MALEIC ANHYDRIDE POLYMER ; Utilisation et sources d'émission. Fabrication de produits textiles, fabrication de colles ou adhésifs

PVP K 30 PVP K 30 is a film former in hair styling products. PVP is an emulsion stabilizer in creams and lotions. PVP can also be a dispersant for hair colorants. PVP K 30 is available as 100% powder and as 20% aqueous solution. PVP (Polyvinylpyrrolidone) K-30 polymer is a hygroscopic, amorphous polymer. PVP K 30 is a linear nonionic polymer that is soluble in water and organic solvents and is pH stable. PVP K 30 forms hard glossy transparent films and have adhesive and cohesive properties. General description Polyvinylpyrrolidone (PVP), also commercially known as K30, is a water soluble polymer. It has a hygroscopic nature with good adhesive properties. It has a stable pH and has the ability to form transparent films. Application PVP has a wide range of usage such as: • an adhesive for making gluesticks and metal adhesives • a dispersant for ceramics • coatings and inks • formation of synthetic fibres and textiles • porous membranes The PVP K 30 E- and I-series To fit more application areas, the E- and I-series of PVP K 30 copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. Storage and handling of PVP K 30 PVP K 30 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 30 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 30) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. USES PVP K 30 is used in as an adhesive in glue stick and hot-melt adhesives PVP K 30 is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP K 30 is used in as an emulsifier and disintegrant for solution polymerization PVP K 30 is used in increase resolution in photoresists for cathode ray tubes (CRT) PVP K 30 is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP K 30 is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP K 30 is used in as a thickening agent in tooth whitening gels PVP K 30 is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP K 30 is used in as an additive to Doro's RNA extraction buffer PVP K 30 is used in as a liquid-phase dispersion enhancing agent in DOSY NMR PVP K 30 is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly PVP K 30 is used in as a stabilizing agent in all inorganic solar cells Other uses of PVP K-30 solution PVP K 30 binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. Applications and Usage Notes of PVP K 30 Adhesives – pressure-sensitive and water-remoistenable types, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks. Ceramics – binder in high temperature fire-prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier. Coatings/lnks – digital printing coating, ball-point inks, protective colloid and leveling agent for emulsion polymers/ coatings/ printing inks, pigment dispersant, water colors for commercial art, temporary protective coatings, paper coatings, waxes and polishes. Electronic Applications – storage batteries, printed circuits, cathode ray tubes, binder for metal salts or amalgams in batteries, gold, nickel, copper and zinc plating, a thickener for solar gel ponds and as an adhesive to prevent leakage of batteries, serves as an expander in cadmium-type electrodes, binder in sintered-nickel powder plates. Membranes – macroporous, multiporous, desalination, gas separating, liquid ultrafiltration, hemodialysis, selective permeability types of membranes, hollow fiber membranes. Metallurgy – processing for both ferrous and non-ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum, used in metal quenchant baths. Paper – cellulose papers, rag stock, rag stripping, copying paper, printing paper and electric insulating papers, paper adhesives. Polymerizations – acrylic monomers, unsaturated polyesters, olefins, including PVC, polystyrene beads, substrate for graft polymerization, template in acrylic polymerization. The PVP K 30 W copolymers PVP K 30 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 30 W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 30 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 30, PVP K 30 E-535 and PVP K 30 E-335. In general, PVP K 30 is less hygroscopic than PVP. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. PVP K-30 20% Solution is a film former in hair styling products. It has an average molecular weight of 1,300,000 in Daltons. Polyvinylpyrrolidone. PVP K-30 solution is a film former. It is suggested for use in hair styling formualations. PVP K-30 solution is a 20 percent solution. It stabilizes emulsions, dispersions and suspensions. It forms clear, hard & glossy film. PVP K 30 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 30 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. What is PVP K 30 Copolymer? PVP K 30 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. The advantages of using PVP K 30 copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP K 30 copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid To fit many application areas, the E and I series of PVP K 30 copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. PVP K 30 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 30 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 30) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 30 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 30 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. PVP K 30 is a 70/30 copolymer of PVP K 30 and vinyl acetate supplied as a 50% solution in water. PVP K 30 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 30 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Key Attributes of PVP K 30 Polyvinylpyrrolidone (PVP) can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the pyrrolidone ring. High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts. Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone. Hydrophilicity, where the water solubility of PVP is its dominant feature and frequently a factor along with other properties valuable in numerous applications. Adhesion, taking advantage of the higher molecular weight PVP formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application. Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques. In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP K 30) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP K 30 , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP K 30 acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP K 30 finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP K 30 thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP K 30 used in industrial, specialty and imaging coatings, printing inks and paints. PVP K 30 provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. Uses of PVP K-30 solution Medical uses of PVP K-30 solution PVP K 30 was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP K 30 is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown.) PVP K 30 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP K 30 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. PVP K 30 is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. PVP K 30 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP K 30 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP K 30 is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP K 30 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP K 30 is useful for making an aqueous mounting medium. PVP K 30 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production. Safety of PVP K 30 The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP K 30 has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP K 30 component of the solution. A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP. In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP. Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP K 30 instead. Properties of PVP K 30 PVP K 30 is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin). When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP K 30 and its oxidized hydrolyzate. History of PVP K 30 PVP K 30 was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP K 30 was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. The PVP K 30 copolymer PVP K 30 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. PVP K 30 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 30 W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP K 30 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 30 E-735 copolymer, PVP K 30 E-535 copolymer and PVP K 30 E- 335 copolymer. In general, PVP K 30 copolymer is less hygroscopic than PVP. PVP K 30 copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP K 30 copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP K 30 copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP K 30 copolymer is used as a binder to allow the aqueous processing of photoresists. PVP K 30 is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. PVP K 30 is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP K 30 monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives. Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP K 30 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP K 30 (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP K 30 tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP K 30 Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid.

PVP K 60 Applications and Usage Notes Adhesives – pressure-sensitive and water-remoistenable types, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks. Ceramics – binder in high temperature fire-prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier. Coatings/lnks – digital printing coating, ball-point inks, water colors for commercial art, temporary protective coatings, paper coatings. Lithography and Photography – foil emulsions, etch coatings, plate storage, gumming of lithographic plates, dampener roll solutions, photo and laser imaging processes. Metallurgy – processing for both ferrous and non-ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum, used in metal quenchant baths. Paper – inorganic papers, cellulose papers, rag stock, rag stripping, coloring and beating operations, copying paper, printing paper and electric insulating papers, paper adhesives. PVP K 60 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 60) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. Application of PVP K 60 Polyvinylpyrrolidone solution (PVP) is also known as K60 and can be used in a variety of applications such as biomedical, tissue engineering, and medical materials. To fit more application areas, the E- and I-series of PVP K 60 copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. PVP K 60 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 60 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. PVP K 60 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. PVP K 60 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 60 W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Other uses of PVP K-60 solution PVP K 60 binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP K 60 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP K 60 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP K 60 is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP K 60 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP K 60 is useful for making an aqueous mounting medium. PVP K 60 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production. Safety of PVP K 60 The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP K 60 has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP K 60 component of the solution. A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP. In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP. Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP K 60 instead. Plasticizers and polymers: Most PVP K 60 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 60, PVP K 60 E-535 and PVP K 60 E-335. In general, PVP K 60 is less hygroscopic than PVP. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Storage and handling of PVP K 60 PVP K 60 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. PVP K-60 20% Solution is a film former in hair styling products. It has an average molecular weight of 1,300,000 in Daltons. Polyvinylpyrrolidone. PVP K-60 solution is a film former. It is suggested for use in hair styling formualations. PVP K-60 solution is a 20 percent solution. It stabilizes emulsions, dispersions and suspensions. It forms clear, hard & glossy film. In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP K 60) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP K 60 , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. The advantages of using PVP K 60 copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP K 60 copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties Key Attributes of PVP K 60 -Polyvinylpyrrolidone (PVP) can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the pyrrolidone ring. -High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts. -Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone. -Hydrophilicity, where the water solubility of PVP is its dominant feature and frequently a factor along with other properties valuable in numerous applications. -Adhesion, taking advantage of the higher molecular weight PVP formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application. -Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques. Applications and Usage Notes of PVP K 60 -Adhesives – pressure-sensitive and water-remoistenable types, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks. -Ceramics – binder in high temperature fire-prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier. -Coatings/lnks – digital printing coating, ball-point inks, protective colloid and leveling agent for emulsion polymers/ coatings/ printing inks, pigment dispersant, water colors for commercial art, temporary protective coatings, paper coatings, waxes and polishes. -Electronic Applications – storage batteries, printed circuits, cathode ray tubes, binder for metal salts or amalgams in batteries, gold, nickel, copper and zinc plating, a thickener for solar gel ponds and as an adhesive to prevent leakage of batteries, serves as an expander in cadmium-type electrodes, binder in sintered-nickel powder plates. -Membranes – macroporous, multiporous, desalination, gas separating, liquid ultrafiltration, hemodialysis, selective permeability types of membranes, hollow fiber membranes. -Metallurgy – processing for both ferrous and non-ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum, used in metal quenchant baths. -Paper – cellulose papers, rag stock, rag stripping, copying paper, printing paper and electric insulating papers, paper adhesives. -Polymerizations – acrylic monomers, unsaturated polyesters, olefins, including PVC, polystyrene beads, substrate for graft polymerization, template in acrylic polymerization. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. PVP K 60 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP K 60 acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP K 60 finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP K 60 thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP K 60 used in industrial, specialty and imaging coatings, printing inks and paints. PVP K 60 provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP K 60 is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. PVP K 60 is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP K 60 monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives. Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP K 60 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP K 60 (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP K 60 tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP K 60 Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. PVP K 60 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 60) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 60 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 60 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. PVP K 60 is a 70/30 copolymer of PVP K 60 and vinyl acetate supplied as a 50% solution in water. PVP K 60 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 60 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Uses of PVP K-60 solution Medical uses of PVP K-60 solution PVP K 60 was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP K 60 is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown.) PVP K 60 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP K 60 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. PVP K 60 is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Properties of PVP K 60 PVP K 60 is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin). When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP K 60 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 60 E-735 copolymer, PVP K 60 E-535 copolymer and PVP K 60 E- 335 copolymer. In general, PVP K 60 copolymer is less hygroscopic than PVP. USES of PVP K 60 It is used in as an adhesive in glue stick and hot-melt adhesives It is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP K 60 is used in as an emulsifier and disintegrant for solution polymerization It is used in increase resolution in photoresists for cathode ray tubes (CRT) PVP K 60 is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters It is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating It is used in as a thickening agent in tooth whitening gels PVP K 60 is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation It is used in as an additive to Doro's RNA extraction buffer It is used in as a liquid-phase dispersion enhancing agent in DOSY NMR PVP K 60 is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly PVP K 60 is used in as a stabilizing agent in all inorganic solar cells PVP K 60 copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP K 60 copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP K 60 copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP K 60 copolymer is used as a binder to allow the aqueous processing of photoresists. History of PVP K 60 PVP K 60 was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP K 60 was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. The PVP K 60 copolymer PVP K 60 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. PVP K 60 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 60 W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution.

PVP K 85 PVP K 85 Solution is a hygroscopic, amorphous polymer supplied as a clear aqueous solution. It can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. This product is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. PVP products are recommended for dishwashing, fabric care, household cleaning, and industrial and institutional cleaning applications. Polyvinylpyrrolidone (PVP K 85). It is in form of aqueous solution. It is linear, random and is produced by the free-radical polymerization. It is hygroscopic and amorphous. It has high polarity, dispersany, adhesion and cohesion. It forms hard, glossy and oxygen permeable film. It is soluble in water and polar solvents. Insoluble in esters, ethers, ketones and hydrocarbons. Suitable for digital ink-jet printing. PVP K 85 100% Powder is soluble in water and many organic solvents and it forms hard, transparent, glossy film. PVP is compatible with most inorganic salts and many resins. PVP stabilizes emulsions, dispersions and suspensions. While PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K 85 100% Powder appears as a white powder. PVP (Polyvinylpyrrolidone) K-85 polymer is a hygroscopic, amorphous polymer. They are linear nonionic polymers that are soluble in water and organic solvents and are pH stable. PVP K 85 forms hard glossy transparent films and have adhesive, cohesive and dispersive properties. Key Attributes of PVP K 85  Polyvinylpyrrolidone (PVP) can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the pyrrolidone ring.  High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.  Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone.  Hydrophilicity, where the water solubility of PVP is its dominant feature and frequently a factor along with other properties valuable to numerous applications.  Adhesion, taking advantage of the molecular weight PVP formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.  Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques. Applications and Usage Notes  Adhesives – pressure-sensitive and water-remoistenable types of adhesives, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks.  Ceramics – binder in high temperature fire prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier.  Glass and Glass Fibers – acts as a binder, lubricant and coating agent.  Coatings/lnks – digital printing coating, ball-point inks, protective colloid and leveling agent for emulsion polymers/ coatings/ printing inks, pigment dispersant, water-colors for commercial art, temporary protective coatings, paper coatings, waxes and polishes.  Electronic Applications – storage batteries, printed circuits, cathode ray tubes, binder for metal salts or amalgams in batteries, gold, nickel, copper and zinc plating, a thickener for solar gel ponds and as an adhesive to prevent leakage of batteries, serves as an expander in cadmium-type electrodes, binder in sintered-nickel powder plates.  Lithography and Photography – foil emulsions, etch coatings, plate storage, gumming of litho- graphic plates, dampener roll solutions, photo and laser imaging processes, microencapsulation, thermal recording, carrier, finisher preserver of lithographic plates, thermal transfer recording ribbons and optical recording discs.  Fibers and Textiles – synthetic fibers, dyeing and printing, fugitive tinting, dye stripping and dispersant, scouring, delustering, sizing and finishing, greaseproofing aid, soil release agent. Widely used as dye dispersant and to disperse titanium dioxide.  Membranes – macroporous, multiporous, desalination, gas separating, liquid ultrafiltration, hemodialysis, selective permeability types of membranes, hollow fiber membranes.  Metallurgy – processing for both ferrous and non ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum.  Paper – inorganic papers, cellulose papers, rag stock, rag stripping, coloring and beating operations, copying paper, printing paper and electric insulating papers, paper adhesives.  Polymerizations – acrylic monomers, unsaturated polyesters, olefins, including PVC, styrene beads, substrate for graft polymerization, template in acrylic polymerization.  Water and Waste Treatment, and Hygiene – clogging of reverse osmosis membranes, water treatment in fish hatchery ponds, removal of oil, dyes from waste water and waste water clarifier in papermaking, in deodorants for neutralization of irritant and poisonous gas, in air conditioning filters. Polyvinylpyrrolidone (PVP K 85) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/85 to 85/70 vinyl acetate to vinylpyrrolidone. PVP K 85 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (85, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 85 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. What is PVP K 85 Copolymer? PVP K 85 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP K 85 copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal. The advantages of using PVP K 85 copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP K 85 copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP K 85 E and I copolymer Series To fit many application areas, the E and I series of PVP K 85 copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. The PVP K 85 copolymer PVP K 85 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. The PVP K 85 W copolymers PVP K 85 copolymer is a 70/85 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 85 W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP K 85 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 85 E-735 copolymer, PVP K 85 E-535 copolymer and PVP K 85 E- 335 copolymer. In general, PVP K 85 copolymer is less hygroscopic than PVP. PVP K 85 copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP K 85 copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP K 85 copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP K 85 copolymer is used as a binder to allow the aqueous processing of photoresists. Storage and handling PVP K 85 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 85 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 85 ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/85 to 85/70 vinyl acetate to vinylpyrrolidone. PVP K 85 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (85, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 85 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP K 85 E- and I-series To fit more application areas, the E- and I-series of PVP K 85 copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP K 85 W copolymers PVP K 85 is a 70/85 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 85 W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 85 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 85, PVP K 85 E-535 and PVP K 85 E-335. In general, PVP K 85 is less hygroscopic than PVP. Abstract In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP K 85 ) copolymer compositions (70/85, 60/40, 50/50 and 85/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP K 85 , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP K 85 acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP K 85 finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP K 85 thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP K 85 used in industrial, specialty and imaging coatings, printing inks and paints. PVP K 85 provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP K 85 is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene.[2] PVP K 85 is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP K 85 monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives.[2] Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP K 85 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP K 85 (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP K 85 tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below) Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP K 85 Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. The PVP K 85 E and I copolymer Series To fit many application areas, the E and I series of PVP K 85 copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-735, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Storage and handling PVP K 85 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 85 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 85 ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/85 to 85/70 vinyl acetate to vinylpyrrolidone. PVP K 85 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (85, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 85 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP K 85 W copolymers PVP K 85 is a 70/85 copolymer of PVP K 85 and vinyl acetate supplied as a 50% solution in water. PVP K 85 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 85 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. USES Medical PVP K 85 was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP K 85 is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.) PVP K 85 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP K 85 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5] PVP K 85 is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Technical PVP K 85 is used in as an adhesive in glue stick and hot-melt adhesives PVP K 85 is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP K 85 is used in as an emulsifier and disintegrant for solution polymerization PVP K 85 is used in increase resolution in photoresists for cathode ray tubes (CRT)[9] PVP K 85 is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP K 85 is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP K 85 is used in as a thickening agent in tooth whitening gels[10] PVP K 85 is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP K 85 is used in as an additive to Doro's RNA extraction buffer[citation needed] PVP K 85 is used in as a liquid-phase dispersion enhancing agent in DOSY NMR [11] PVP K 85 is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12] PVP K 85 is used in as a stabilizing agent in all inorganic solar cells[13] Other uses PVP K 85 binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP K 85 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP K 85 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP K 85 is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP K 85 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP K 85 is useful for making an aqueous mounting medium.[16] PVP K 85 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17] Safety of PVP K 85 The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP K 85 has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP K 85 component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21] Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP K 85 instead. Properties of PVP K 85 PVP K 85 is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP K 85 and its oxidized hydrolyzate. History of PVP K 85 PVP K 85 was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP K 85 was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.

PVP K 90 PVP K 90 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 90 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. What is PVP K 90 Copolymer? PVP K 90 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Storage and handling of PVP K 90 PVP K 90 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 90 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 90) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. The PVP K 90 E- and I-series To fit more application areas, the E- and I-series of PVP K 90 copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP K 90 W copolymers PVP K 90 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 90 W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 90 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 90, PVP K 90 E-535 and PVP K 90 E-335. In general, PVP K 90 is less hygroscopic than PVP. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. PVP K-90 20% Solution is a film former in hair styling products. It has an average molecular weight of 1,300,000 in Daltons. Polyvinylpyrrolidone. PVP K-90 solution is a film former. It is suggested for use in hair styling formualations. PVP K-90 solution is a 20 percent solution. It stabilizes emulsions, dispersions and suspensions. It forms clear, hard & glossy film. Key Attributes of PVP K 90 Polyvinylpyrrolidone (PVP) can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the pyrrolidone ring. High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts. Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone. Hydrophilicity, where the water solubility of PVP is its dominant feature and frequently a factor along with other properties valuable in numerous applications. Adhesion, taking advantage of the higher molecular weight PVP formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application. Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques. Applications and Usage Notes of PVP K 90 Adhesives – pressure-sensitive and water-remoistenable types, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks. Ceramics – binder in high temperature fire-prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier. Coatings/lnks – digital printing coating, ball-point inks, protective colloid and leveling agent for emulsion polymers/ coatings/ printing inks, pigment dispersant, water colors for commercial art, temporary protective coatings, paper coatings, waxes and polishes. Electronic Applications – storage batteries, printed circuits, cathode ray tubes, binder for metal salts or amalgams in batteries, gold, nickel, copper and zinc plating, a thickener for solar gel ponds and as an adhesive to prevent leakage of batteries, serves as an expander in cadmium-type electrodes, binder in sintered-nickel powder plates. Membranes – macroporous, multiporous, desalination, gas separating, liquid ultrafiltration, hemodialysis, selective permeability types of membranes, hollow fiber membranes. Metallurgy – processing for both ferrous and non-ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum, used in metal quenchant baths. Paper – cellulose papers, rag stock, rag stripping, copying paper, printing paper and electric insulating papers, paper adhesives. Polymerizations – acrylic monomers, unsaturated polyesters, olefins, including PVC, polystyrene beads, substrate for graft polymerization, template in acrylic polymerization. Abstract of PVP K-90 solution In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP K 90) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP K 90 , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. The advantages of using PVP K 90 copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP K 90 copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP K 90 E and I copolymer Series To fit many application areas, the E and I series of PVP K 90 copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. PVP K 90 copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 90 polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 90) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 90 copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 90 copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. PVP K 90 is a 70/30 copolymer of PVP K 90 and vinyl acetate supplied as a 50% solution in water. PVP K 90 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 90 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP K 90 acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP K 90 finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP K 90 thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP K 90 used in industrial, specialty and imaging coatings, printing inks and paints. PVP K 90 provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP K 90 is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. PVP K 90 is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP K 90 monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives. Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP K 90 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP K 90 (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP K 90 tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP K 90 Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. Uses of PVP K-90 solution Medical uses of PVP K-90 solution PVP K 90 was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP K 90 is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown.) PVP K 90 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP K 90 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. PVP K 90 is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Properties of PVP K 90 PVP K 90 is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin). When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP K 90 and its oxidized hydrolyzate. History of PVP K 90 PVP K 90 was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP K 90 was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. The PVP K 90 copolymer PVP K 90 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. PVP K 90 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 90 W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP K 90 copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 90 E-735 copolymer, PVP K 90 E-535 copolymer and PVP K 90 E- 335 copolymer. In general, PVP K 90 copolymer is less hygroscopic than PVP. PVP K 90 copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP K 90 copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP K 90 copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP K 90 copolymer is used as a binder to allow the aqueous processing of photoresists. USES PVP K 90 is used in as an adhesive in glue stick and hot-melt adhesives PVP K 90 is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP K 90 is used in as an emulsifier and disintegrant for solution polymerization PVP K 90 is used in increase resolution in photoresists for cathode ray tubes (CRT) PVP K 90 is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP K 90 is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP K 90 is used in as a thickening agent in tooth whitening gels PVP K 90 is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP K 90 is used in as an additive to Doro's RNA extraction buffer PVP K 90 is used in as a liquid-phase dispersion enhancing agent in DOSY NMR PVP K 90 is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly PVP K 90 is used in as a stabilizing agent in all inorganic solar cells Other uses of PVP K-90 solution PVP K 90 binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP K 90 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP K 90 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP K 90 is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP K 90 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP K 90 is useful for making an aqueous mounting medium. PVP K 90 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production. Safety of PVP K 90 The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP K 90 has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP K 90 component of the solution. A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP. In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP. Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP K 90 instead.

PVP K 90 is soluble in water and many organic solvents and it forms hard, transparent, glossy film.
PVP K 90 is compatible with most inorganic salts and many resins.
PVP K 90 stabilizes emulsions, dispersions and suspensions.

CAS: 9003-39-8
MF: CH4
MW: 16.04246
EINECS: 1312995-182-4

PVP K 90, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
PVP K 90 is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
While PVP K 90 is used as a film former in hair styling products, PVP K 90 can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP K 90 can be used in toothpastes and mouthwashes.
PVP K 90 appears as a white powder.

PVP K 90 is abbreviated as PVP, and is the polymer of vinylpyrrolidone.
According to the different degree of polymerization, PVP K 90 is further classified into soluble PVP and insoluble PVPP (polyvinyl polypyrrolidone).
Molecular weight of the soluble PVP K 90 is 8,000 to 10,000.
The soluble PVP K 90 can be used as a precipitating agent which can be settle down through its action with polyphenols.
Using this method, PVP K 90 is easily to have residual PVP in the alcohol.
Due to the savings effect of PVP K 90 inside the human body, the World Health Organization doesn’t recommend to apply this substance.

In recent years, the use of soluble PVP K 90 has been rare.
Insoluble PVP K 90 system had began to be used in the beer industry since the early 1960s.
PVP K 90 has a relative molecule weight greater than the relative mass greater than 700,000.
PVP K 90 is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy.

PVP K 90 is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.
PVP K 90 is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.

PVP K 90 and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
The film PVP K 90 formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.
Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Therefore, PVP K 90 is an indispensable raw material in styling hair cream, hair gel, and mousse.
PVP K 90 can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.
Insoluble PVP K 90 is the stabilizer of beer and juice which can improve its transparency, color, and flavor.

PVP K 90 is a water soluble polyamide.
Commercially available PVP K 90 is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively.
K value or molecular weight is an important factor which decides the various properties of PVP.
PVP K 90 is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether.

PVP K 90 used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7.
PVP K 90 is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point.
Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP K 90’s hygroscopicity and softness.
PVP K 90 is not prone to have chemical reaction.
Under normal storage conditions, dry PVP K 90 is quite stable.
PVP K 90 has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic.

Because of the hydrogen bonding or complexation effect, PVP K 90’s viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state.
The dropping pill whose matrix is PVP K 90 can enhance the dissolution and bioavailability of poorly soluble drugs.
In general, the greater the PVP K 90 amount, the higher dissolution and solubility of drug in the medium.
Susana et al have studied the dissolution of the PVP K 90 solid dispersant of the slightly soluble drug albendazole.
The increased amount of PVP K 90 can increase the dissolution rate and efficiency of drug inside the solid dispersant.

Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in PVP K 90 solid dispersant and obtained similar conclusion.
PVP K 90 also found that the higher the content, the more significant increase in dissolution.
IR has showed that flunarizine and PVP K 90 has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the PVP.
Tantishaiyakul et al has found that: when the ratio of piroxicam: PVP K 90 is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min.
PVP K 90 can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix.

PVP K 90, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent.
Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions.
This has led to the withdrawal of PVP K 90 from such preparations in some countries.
PVP K 90 was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued.
However, PVP K 90 remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.

PVP K 90 Chemical Properties
Melting point: >300 °C
Boiling point: 90-93 °C
Density: 1,69 g/cm3
Storage temp.: 2-8°C
Solubility H2O: soluble100mg/mL
Form: powder
Color: White to yellow-white
PH: 3.0-5.0
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
Merck: 14,7697
Stability: Stable. Incompatible with strong oxidizing agents.
Light sensitive. Hygroscopic.
InChI: InChI=1S/C8H15NO/c1-3-7(2)9-6-4-5-8(9)10/h7H,3-6H2,1-2H3
InChIKey: FAAHNQAYWKTLFD-UHFFFAOYSA-N
IARC: 3 (Vol. 19, Sup 7, 71) 1987
EPA Substance Registry System: PVP K 90 (9003-39-8)

Commonly used PVP K 90 level in the cosmetic industry is K-30.
Commercialized PVP K 90 is white and free flowing powder or solids with its content in the mass fraction of 20%, 30%, 45% and 50% aqueous solution.
PVP K 90 is soluble in water and is hygroscopic with a moisture equilibrium being 1/3 of the relative humidity of the environment.
Similar as the protein hydration action, each monomer associates with 0.5mol water.
PVP K 90 is not easy to have chemical reaction.

When stored at normal conditions, dry PVP K 90 is quite stable.
Solution undergone mildew treatment is also stable.
When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, PVP K 90 will be exchanged to become a water-insoluble compound.
In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP K 90 solution to become gel.
The co-heating of PVP K 90 solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation.
Many different compounds can generate complexes with PVP.

For example, the complexes of PVP and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of PVP K 90 will generate insoluble complexes which are insoluble in water, alcohols and ketones.
But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between PVP K 90 and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with PVP K 90, which is the basis for using PVP K 90 as a dye bleaching agent.

PVP K 90 is the cross-linked homopolymer of pure vinylpyrrolidone.
PVP K 90 is hygroscopic and free-flowing white or off-white powder.
PVP K 90 has a slight foul smell.
PVP K 90 is insoluble in common solvents such as water, ethanol and ether.
So PVP K 90's molecule weight range can’t be measured.
However, PVP K 90 has ability to form complex with various kinds of substances (such as “Hu” class substance which can lead to the discoloration of a variety of wines and beverages discoloration).

Also PVP K 90 is easily to be removed after filtration because of its insolubility.
PVP K 90 occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder.
PVP K 90 with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres.
PVP K 90 and higher K-value povidones are manufactured by drum drying and occur as plates.

PVP K 90 is soluble in water and other polar solvents.
For example, PVP K 90 is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).
When dry PVP K 90 is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water.
In solution, PVP K 90 has excellent wetting properties and readily forms films.
This makes PVP K 90 good as a coating or an additive to coatings.
A 2014 study found fluorescent properties of PVP K 90 and its oxidized hydrolyzate.

Uses
In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP K 90 sprays which are still widely used until now.
PVP K 90 can form wet, transparent film on the hair which is shiny and has good lubrication effect.
PVP K 90 has good compatibility with a variety of good propellant and also has corrosion resistance.
PVP K 90 is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer.

PVP K 90 has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes.
PVP K 90 is also used as toothpaste detergents, gelling agents and antidotes.
The main drawback of PVP K 90 is its sensitivity to moisture.
However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity.
In addition, PVP K 90 also has wide application in the pharmaceutical, beverage and textile industries.

Clarifying agent; pigment stabilizer; colloidal stabilizer; PVP K 90 is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents.
PVP K 90 is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L).
Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; PVP K 90 of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine.
Used as the fixing liquid for gas chromatography.

PVP K 90 is used as a colloidal stabilizer and clarifying agent for beer clarification. Apply proper amount according the demands of production.
PVP K 90 can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.
PVP K 90 molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste.
The products have two specifications: disposable type and regeneration type.
Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since PVP K 90 is recyclable, it is suitable for large breweries for recycle application.

In daily cosmetics, PVP K 90 and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye.
Adding PVP K 90 to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect.
Taking advantage of the excellent properties of PVP K 90 such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products.

PVP K 90 is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels.
PVP K 90 finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions.
PVP K 90 is used as a food additive and in the wine industry as a fining agent for white wine.
PVP K 90 is used as a capping agent to synthesize silver nanowires through a polyol process.

Pharmaceutical Applications
Although PVP K 90 is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms.
In tableting, PVP K 90 solutions are used as binders in wet-granulation processes.
PVP K 90 is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions.
PVP K 90 is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms.

PVP K 90 solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
PVP K 90 is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions.
The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Special grades of pyrogen-free PVP K 90 are available and have been used in parenteral formulations.

Medical
PVP K 90 is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally.
PVP K 90 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
PVP K 90 is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs.
PVP K 90 is sold under the trade names Pyodine and Betadine, among others.
PVP K 90 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, PVP K 90 is as effective and safe as talc, and may be preferred because of easy availability and low cost.

PVP K 90 is used in some contact lenses and their packaging solutions.
PVP K 90 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
PVP K 90 is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.
PVP K 90 was used as a plasma volume expander for trauma victims after the 1950s.

PVP K 90 is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping.
Autopsies have found that PVP K 90 contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.
The long-term effects of crospovidone or povidone within the lung are unknown.

Technical
PVP K 90 is also used in many technical applications:
as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process,
as an emulsifier and disintegrant for solution polymerization,
to increase resolution in photoresists for cathode ray tubes (CRT),
in aqueous metal quenching,
for production of membranes, such as dialysis and water purification filters,
as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating,
as a thickening agent in tooth whitening gels,
as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms,(syrups, soft gelatine capsules) and as an inhibitor of recrystallisation,
as an additive to Doro's RNA extraction buffer,
as a liquid-phase dispersion enhancing agent in DOSY NMR,
as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle, synthesis and their self-assembly,
as a stabilizing agent in all inorganic solar cells.

Other uses
PVP K 90 binds to polar molecules exceptionally well, owing to its polarity.
This has led to PVP K 90's application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
PVP K 90 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes.
PVP K 90 has also been used in contact lens solutions and in steel-quenching solutions.
PVP K 90 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
As a food additive, PVP K 90 is a stabilizer and has E number E1201.
PVPP (crospovidone) is E1202.

PVP K 90 is also used in the wine industry as a fining agent for white wine and some beers.
In in-vitro fertilisation laboratories, PVP K 90 is used to slow down spermatozoa in order to capture them for e.g. ICSI.
In molecular biology, PVP K 90 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
PVP K 90 is also exceptionally good at absorbing polyphenols during DNA purification.
Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
In microscopy, PVP is useful for making an aqueous mounting medium.
PVP K 90 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.

Identification Test
Solubility: soluble in water, ethanol and chloroform and insoluble in ether.
This is measured by the OT-42 method.
Dichromate precipitation test: in 5 mL of2% sample solution, add 5 mL dilute hydrochloric acid solution (TS-117), further add 5 mL of water plus 2 mL of 10% potassium dichromate solution and 2ml.
This should form an orange precipitate.
Take 75 mg of cobalt nitrate and 300 mg of ammonium thiocyanate for being dissolved in 2ml of water; add 5 mL of 2% aqueous sample solution; after the mixing, add dilute hydrochloric acid test solution (TS-117) for acidification.
This should form light blue precipitate.
Take 5 mL of 2% sample solution; add 1 mL of 25% hydrochloric acid, 5 mL of 5% barium chloride and 1 mL 5% molybdenum tungsten phosphoric acid solution.

This should generate a lot of white precipitate which gradually turns blue in the sunlight.
The pH value of 5% sample solution should be 3.0 to 3.7.
This is measured by conventional means.
Adding a few drops of iodine test solution (TS-124) to 5 mL of 0.5% sample solution should produce a deep red color.
Take 1 g of sample, add water to 10 ml as a suspension, add 0.1 mL of iodine test solution (TS-124), after mixing by shaking for 30s, iodine test solution should fade (to distinguish polyvinylpyrrolidone due to that polyvinylpyrrolidone can form red color).
Add 1 mL of starch test solution (TS-235), after shaking and mixing, there should be no blue color formed. to produce blue.

Production method
PVP K 90's crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction.
Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h).
The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product.

PVP K 90 is manufactured by the Reppe process.
Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone.
PVP K 90 is produced by reacting butyrolactone with ammonia.
This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure.
The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.

Contact Allergens
PVP K 90 is widely used as is in cosmetics such as hair care products and in medical products.
PVP K 90 acts as iodophor in iodine-polyvinylpyrrolidone.
PVP K 90 is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten).
PVP K 90 may cause type I contact urticaria or anaphylaxis.

Biochem/physiol Actions
PVP K 90 can bind to polyphenol.
Thus, PVP K 90 is known to be used for RNA isolation from plants rich in polyphenols.
PVP K 90 is extensively used in the synthesis of nanoparticles.

Synonyms
N-VINYL-2-PYRROLIDONE
88-12-0
1-vinylpyrrolidin-2-one
N-Vinylpyrrolidone
1-Vinyl-2-pyrrolidone
9003-39-8
N-Vinyl-2-pyrrolidinone
1-Vinyl-2-pyrrolidinone
Vinylpyrrolidone
Povidone
1-ethenylpyrrolidin-2-one
N-Vinylpyrrolidinone
2-Pyrrolidinone, 1-ethenyl-
1-Vinylpyrrolidone
Vinylbutyrolactam
Vinylpyrrolidinone
V-Pyrol
Luviskol
Plasdone
1-Vinylpyrrolidinone
25249-54-1
Vinyl-2-pyrrolidone
N-Vinyl pyrrolidone
1-Ethenyl-2-pyrrolidinone
N-Vinylpyrrolidone-2
2-Pyrrolidinone, 1-vinyl-
1-Vinyl-2-pyrrolidinone, monomer
PVP
NSC 10222
MPK 90
PVP 40
DTXSID2021440
143 RP
AT 717
1-vinyl-pyrrolidin-2-one
K 15
K 90
PVP-40
CHEBI:82551
MFCD00003197
NSC-10222
76H9G81541
DTXCID101440
WLN: /T5NVTJ AY*1*/
MFCD01076626
CAS-88-12-0
K 25
K 115
HSDB 7231
EINECS 201-800-4
BRN 0110513
CCRIS 8581
PovidonePVP
vinyl pyrrolidone
UNII-76H9G81541
N-vinyl-pyrrolidone
N -vinylpyrrolidinone
1-vinyl-2-pyrrolidon
POVIDONE MONOMER
VINYLBUTYLOLACTAM
N-vinylpyrrolidin-2-one
N-vinyl pyrrolidin-2-one
N-vinyl-pyrrolidin-2-one
PVP K3O
Crospovidone ~40,000
EC 201-800-4
SCHEMBL10869
WLN: T5NVTJ A1U1
PVP K15
PVP K30
PVP-K30
POVIDONE MONOMER [MI]
VINYL PYRROLIDONE (VP)
CHEMBL1878943
PVP - K-30 (Pharm Grade)
N-VINYL PYRROLIDONE [INCI]
1-Vinyl-2-pyrrolidone(stabilized with 200ppm Ammonium hydroxide)
NSC10222
Tox21_202462
Tox21_300073
NSC114022
NSC142693
NSC683040
N-Vinyl-2-pyrrolidone, optical grade
Polyvinylpyrrolidone (MW ~40,000)
AKOS000119985
N-VINYL-2-PYRROLIDONE [IARC]
AT18510
CS-W020981
FG-0420
NSC-114022
NSC-142693
NSC-683040
NCGC00166252-01
NCGC00166252-02
NCGC00166252-03
NCGC00254200-01
NCGC00260011-01
2-PYRROLIDINONE, 1-ETHENYL- [HSDB]
FT-0608329
FT-0645144
FT-0655284
V0026
EN300-19745
C19548
A817742
A843417
Q420628
SR-01000944531
J-015891
SR-01000944531-1
W-100417
1-Vinyl-2-pyrrolidinone, SAJ first grade, >=99.0%
F8881-5579
Z104475034
3-CHLORO-5,6-DIFLUORO-1-BENZOTHIOPHENE-2-CARBONYLCHLORIDE
1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, >=99%
1-Vinyl-2-pyrrolidinone, Pharmaceutical Secondary Standard; Certified Reference Material
1-Vinyl-2-pyrrolidone (stabilized with N,N'-Di-sec-butyl-p-phenylenediamine)

PVP K 90 Solution PVP K-90 20% Solution is a film former in hair styling products. It has an average molecular weight of 1,300,000 in Daltons. Polyvinylpyrrolidone. PVP K-90 solution is a film former. It is suggested for use in hair styling formualations. PVP K-90 solution is a 20 percent solution. It stabilizes emulsions, dispersions and suspensions. It forms clear, hard & glossy film. Key Attributes of PVP K 90 solution  Polyvinylpyrrolidone (PVP) can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the pyrrolidone ring.  High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.  Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone.  Hydrophilicity, where the water solubility of PVP is its dominant feature and frequently a factor along with other properties valuable in numerous applications.  Adhesion, taking advantage of the higher molecular weight PVP formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.  Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques. Applications and Usage Notes of PVP K 90 solution  Adhesives – pressure-sensitive and water-remoistenable types, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks.  Ceramics – binder in high temperature fire-prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier.  Coatings/lnks – digital printing coating, ball-point inks, protective colloid and leveling agent for emulsion polymers/ coatings/ printing inks, pigment dispersant, water colors for commercial art, temporary protective coatings, paper coatings, waxes and polishes.  Electronic Applications – storage batteries, printed circuits, cathode ray tubes, binder for metal salts or amalgams in batteries, gold, nickel, copper and zinc plating, a thickener for solar gel ponds and as an adhesive to prevent leakage of batteries, serves as an expander in cadmium-type electrodes, binder in sintered-nickel powder plates.  Membranes – macroporous, multiporous, desalination, gas separating, liquid ultrafiltration, hemodialysis, selective permeability types of membranes, hollow fiber membranes.  Metallurgy – processing for both ferrous and non-ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum, used in metal quenchant baths.  Paper – cellulose papers, rag stock, rag stripping, copying paper, printing paper and electric insulating papers, paper adhesives.  Polymerizations – acrylic monomers, unsaturated polyesters, olefins, including PVC, polystyrene beads, substrate for graft polymerization, template in acrylic polymerization. What is PVP K 90 solution Copolymer? PVP K 90 solution Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Storage and handling of PVP K 90 solution PVP K 90 solution copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 90 solution polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 90 solution) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 90 solution copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 90 solution copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP K 90 solution E- and I-series To fit more application areas, the E- and I-series of PVP K 90 solution copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP K 90 solution W copolymers PVP K 90 solution is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 90 solution W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 90 solution copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 90 solution, PVP K 90 solution E-535 and PVP K 90 solution E-335. In general, PVP K 90 solution is less hygroscopic than PVP. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP K 90 solution copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal. The advantages of using PVP K 90 solution copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP K 90 solution copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP K 90 solution E and I copolymer Series To fit many application areas, the E and I series of PVP K 90 solution copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Abstract of PVP K-90 solution In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP K 90 solution) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP K 90 solution , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP K 90 solution acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP K 90 solution finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP K 90 solution thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP K 90 solution used in industrial, specialty and imaging coatings, printing inks and paints. PVP K 90 solution provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP K 90 solution is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. PVP K 90 solution is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP K 90 solution monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives. Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP K 90 solution Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP K 90 solution (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP K 90 solution tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below) Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP K 90 solution Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. PVP K 90 solution copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 90 solution polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 90 solution) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 90 solution copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 90 solution copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. PVP K 90 solution is a 70/30 copolymer of PVP K 90 solution and vinyl acetate supplied as a 50% solution in water. PVP K 90 solution is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 90 solution copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Uses of PVP K-90 solution Medical uses of PVP K-90 solution PVP K 90 solution was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP K 90 solution is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown.) PVP K 90 solution added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP K 90 solution is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. PVP K 90 solution is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Technical uses of PVP K-90 solution PVP K 90 solution is used in as an adhesive in glue stick and hot-melt adhesives PVP K 90 solution is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP K 90 solution is used in as an emulsifier and disintegrant for solution polymerization PVP K 90 solution is used in increase resolution in photoresists for cathode ray tubes (CRT) PVP K 90 solution is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP K 90 solution is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP K 90 solution is used in as a thickening agent in tooth whitening gels PVP K 90 solution is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP K 90 solution is used in as an additive to Doro's RNA extraction buffer PVP K 90 solution is used in as a liquid-phase dispersion enhancing agent in DOSY NMR PVP K 90 solution is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly PVP K 90 solution is used in as a stabilizing agent in all inorganic solar cells Other uses of PVP K-90 solution PVP K 90 solution binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP K 90 solution is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP K 90 solution is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP K 90 solution is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP K 90 solution can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP K 90 solution is useful for making an aqueous mounting medium. PVP K 90 solution can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production. Safety of PVP K 90 solution The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP K 90 solution has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP K 90 solution component of the solution. A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP. In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP. Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP K 90 solution instead. Properties of PVP K 90 solution PVP K 90 solution is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin). When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP K 90 solution and its oxidized hydrolyzate. History of PVP K 90 solution PVP K 90 solution was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP K 90 solution was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. The PVP K 90 solution copolymer PVP K 90 solution copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. PVP K 90 solution copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 90 solution W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP K 90 solution copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 90 solution E-735 copolymer, PVP K 90 solution E-535 copolymer and PVP K 90 solution E- 335 copolymer. In general, PVP K 90 solution copolymer is less hygroscopic than PVP. PVP K 90 solution copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP K 90 solution copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP K 90 solution copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP K 90 solution copolymer is used as a binder to allow the aqueous processing of photoresists.

PVP K 90 Solution 20% PVP K 90 Solution 20% is a film former in hair styling products. PVP is an emulsion stabilizer in creams and lotions. PVP can also be a dispersant for hair colorants. PVP K 90 is available as 100% powder and as 20% aqueous solution. PVP (Polyvinylpyrrolidone) K-90 polymer is a hygroscopic, amorphous polymer. PVP K 90 solution 20% is a linear nonionic polymer that is soluble in water and organic solvents and is pH stable. PVP K 90 solution 20% forms hard glossy transparent films and have adhesive and cohesive properties. Ashland Specialty Ingredients has the capability to dial the K-value to meet specific customer needs. PVP K-90 20% Solution is a film former in hair styling products. It has an average molecular weight of 1,300,000 in Daltons. Polyvinylpyrrolidone. PVP K-90 solution by Ashland Specialty Chemical is a film former. It is suggested for use in hair styling formualations. PVP K-90 solution is a 20 percent solution. It stabilizes emulsions, dispersions and suspensions. It forms clear, hard & glossy film. Key Attributes of PVP K 90 solution 20%  Polyvinylpyrrolidone (PVP) can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the pyrrolidone ring.  High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.  Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone.  Hydrophilicity, where the water solubility of PVP is its dominant feature and frequently a factor along with other properties valuable in numerous applications.  Adhesion, taking advantage of the higher molecular weight PVP formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.  Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques. Applications and Usage Notes of PVP K 90 solution 20%  Adhesives – pressure-sensitive and water-remoistenable types, food packaging (indirect food contact), metal adhesives, abrasives, sandcore binder, rubber to metal adhesives and glue sticks.  Ceramics – binder in high temperature fire-prepared products such as clay, pottery, porcelain, brick product, dispersant for ceramic media slurries and viscosity modifier.  Coatings/lnks – digital printing coating, ball-point inks, protective colloid and leveling agent for emulsion polymers/ coatings/ printing inks, pigment dispersant, water colors for commercial art, temporary protective coatings, paper coatings, waxes and polishes.  Electronic Applications – storage batteries, printed circuits, cathode ray tubes, binder for metal salts or amalgams in batteries, gold, nickel, copper and zinc plating, a thickener for solar gel ponds and as an adhesive to prevent leakage of batteries, serves as an expander in cadmium-type electrodes, binder in sintered-nickel powder plates.  Membranes – macroporous, multiporous, desalination, gas separating, liquid ultrafiltration, hemodialysis, selective permeability types of membranes, hollow fiber membranes.  Metallurgy – processing for both ferrous and non-ferrous metals, coating ingredient to aid or remove material from metal surfaces such as copper, nickel, zinc and aluminum, used in metal quenchant baths.  Paper – cellulose papers, rag stock, rag stripping, copying paper, printing paper and electric insulating papers, paper adhesives.  Polymerizations – acrylic monomers, unsaturated polyesters, olefins, including PVC, polystyrene beads, substrate for graft polymerization, template in acrylic polymerization. What is PVP K 90 solution 20% Copolymer? PVP K 90 solution 20% Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Storage and handling PVP K 90 solution 20% copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 90 solution 20% polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 90 solution 20% ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 90 solution 20% copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 90 solution 20% copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP K 90 solution 20% E- and I-series To fit more application areas, the E- and I-series of PVP K 90 solution 20% copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP K 90 solution 20% W copolymers PVP K 90 solution 20% is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 90 solution 20% W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 90 solution 20% copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 90 solution 20%, PVP K 90 solution 20% E-535 and PVP K 90 solution 20% E-335. In general, PVP K 90 solution 20% is less hygroscopic than PVP. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP K 90 solution 20% copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal. The advantages of using PVP K 90 solution 20% copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP K 90 solution 20% copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP K 90 solution 20% E and I copolymer Series To fit many application areas, the E and I series of PVP K 90 solution 20% copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Abstract In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP K 90 solution 20% ) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP K 90 solution 20% , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP K 90 solution 20% acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP K 90 solution 20% finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP K 90 solution 20% thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP K 90 solution 20% used in industrial, specialty and imaging coatings, printing inks and paints. PVP K 90 solution 20% provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP K 90 solution 20% is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene.[2] PVP K 90 solution 20% is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP K 90 solution 20% monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives.[2] Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP K 90 solution 20% Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP K 90 solution 20% (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP K 90 solution 20% tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below) Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP K 90 solution 20% Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. The PVP K 90 solution 20% E and I copolymer Series To fit many application areas, the E and I series of PVP K 90 solution 20% copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-735, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Storage and handling PVP K 90 solution 20% copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP K 90 solution 20% polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP K 90 solution 20% ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP K 90 solution 20% copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP K 90 solution 20% copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP K 90 solution 20% W copolymers PVP K 90 solution 20% is a 70/30 copolymer of PVP K 90 solution 20% and vinyl acetate supplied as a 50% solution in water. PVP K 90 solution 20% is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP K 90 solution 20% copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Uses Medical PVP K 90 solution 20% was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP K 90 solution 20% is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.) PVP K 90 solution 20% added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP K 90 solution 20% is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5] PVP K 90 solution 20% is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Technical PVP K 90 solution 20% is used in as an adhesive in glue stick and hot-melt adhesives PVP K 90 solution 20% is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP K 90 solution 20% is used in as an emulsifier and disintegrant for solution polymerization PVP K 90 solution 20% is used in increase resolution in photoresists for cathode ray tubes (CRT)[9] PVP K 90 solution 20% is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP K 90 solution 20% is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP K 90 solution 20% is used in as a thickening agent in tooth whitening gels[10] PVP K 90 solution 20% is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP K 90 solution 20% is used in as an additive to Doro's RNA extraction buffer[citation needed] PVP K 90 solution 20% is used in as a liquid-phase dispersion enhancing agent in DOSY NMR [11] PVP K 90 solution 20% is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12] PVP K 90 solution 20% is used in as a stabilizing agent in all inorganic solar cells[13] Other uses PVP K 90 solution 20% binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP K 90 solution 20% is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP K 90 solution 20% is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP K 90 solution 20% is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP K 90 solution 20% can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP K 90 solution 20% is useful for making an aqueous mounting medium.[16] PVP K 90 solution 20% can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17] Safety of PVP K 90 solution 20% The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP K 90 solution 20% has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP K 90 solution 20% component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21] Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP K 90 solution 20% instead. Properties of PVP K 90 solution 20% PVP K 90 solution 20% is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP K 90 solution 20% and its oxidized hydrolyzate. History of PVP K 90 solution 20% PVP K 90 solution 20% was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP K 90 solution 20% was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. The PVP K 90 solution 20% copolymer PVP K 90 solution 20% copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. The PVP K 90 solution 20% W copolymers PVP K 90 solution 20% copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP K 90 solution 20% W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP K 90 solution 20% copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP K 90 solution 20% E-735 copolymer, PVP K 90 solution 20% E-535 copolymer and PVP K 90 solution 20% E- 335 copolymer. In general, PVP K 90 solution 20% copolymer is less hygroscopic than PVP. PVP K 90 solution 20% copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP K 90 solution 20% copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP K 90 solution 20% copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP K 90 solution 20% copolymer is used as a binder to allow the aqueous processing of photoresists.

PVP K90 (Polyvinylpyrrolidone K90) solution 20% is a liquid formulation containing 20% Polyvinylpyrrolidone with a specific average molecular weight, commonly known as PVP K90.
PVP K 90 solution 20% is a water-soluble polymer derived from the polymerization of vinylpyrrolidone monomers.

CAS Number: 9003-39-8
EC Number: 284-724-8

Polyvinylpyrrolidone, PVP, Povidone, Polyvidone, PVP K90, PVP K30, PVP-I, N-Vinylpyrrolidone polymer, Povidone K90, Povidone K30, Povidone K15, Povidone K17, Povidone K25, Povidone K29/32, Povidone K60, Povidone K85, Polyvinylpyrrolidone K90, Polyvinylpyrrolidone K30, Polyvinylpyrrolidone K15, Polyvinylpyrrolidone K17, Polyvinylpyrrolidone K25, Polyvinylpyrrolidone K29/32, Polyvinylpyrrolidone K60, Polyvinylpyrrolidone K85, PVP iodine complex, PVP/VA copolymer, PVP/VA S-630, PVP/VA 64, PVP/VA W-735, PVP/VA E-335, PVP/VA 73W, PVP/VA 64P, PVP/VA S-630 (W), PVP/VA 73W (W), PVP/VA 735, PVP/VA W-735 (W), PVP/VA 64L, PVP/VA 735L, PVP/VA E-335 (W), PVP/VA S-333, PVP/VA E-335 (W) (W), PVP/VA 73L, PVP/VA W-930, PVP/VA 923, PVP/VA 64L (W), PVP/VA W-930 (W), PVP/VA 923L, PVP/VA 64P (W), PVP/VA E-335 (W) (W), PVP/VA S-630 (W) (W), PVP/VA 73W (W) (W), PVP/VA 64L (W) (W), PVP/VA W-735 (W) (W), PVP/VA 735L (W) (W), PVP/VA W-930 (W) (W), PVP/VA 923L (W) (W), PVP/VA S-630, PVP/VA E-335, PVP/VA W-930, PVP/VA 923.



APPLICATIONS


PVP K 90 solution 20% is widely used in the pharmaceutical industry as a binder in tablet formulations, enhancing the cohesion of the tablets.
PVP K 90 solution 20% serves as a disintegrant in pharmaceutical tablets, aiding in the quick disintegration of the tablet in the digestive system.
PVP K 90 solution 20% is utilized in the production of fast-dissolving oral films, providing a convenient and effective drug delivery method.

In oral care products, such as toothpaste and mouthwash, PVP contributes to stability, texture, and consistency.
The film-forming properties of PVP make it valuable in the cosmetic industry, especially in the formulation of hairsprays and styling gels.
PVP K 90 solution 20% is a common ingredient in topical formulations, where it stabilizes and enhances the consistency of ointments, creams, and gels.

PVP K 90 solution 20% is employed in transdermal drug delivery systems to improve the absorption of drugs through the skin.
PVP K 90 solution 20% is used as an antiseptic in healthcare and first aid products, such as wound care solutions.

The pharmaceutical industry utilizes different grades of PVP, such as PVP K30 and PVP K90, based on specific molecular weight requirements.
PVP K 90 solution 20% is a key component in the production of contact lens solutions, providing lubricating and cleaning properties.
PVP K 90 solution 20% is found in over-the-counter medications for its pharmaceutical and therapeutic properties.

PVP K 90 solution 20% contributes to the stability and shelf life of certain formulations due to its stabilizing effects.
In the food industry, PVP is used as a clarifying agent in the production of beverages.
PVP K 90 solution 20% is employed in the creation of specialty coatings for pharmaceutical tablets, ensuring uniformity and stability.
PVP K 90 solution 20% is used in the production of wound care products, such as dressings and adhesive tapes.

PVP K 90 solution 20% is included in the formulation of instant cold packs, contributing to the gel-like consistency when activated.
PVP K 90 solution 20% is a valuable component in the cosmetic industry, contributing to the formulation of mascara for its film-forming characteristics.
PVP K 90 solution 20% is utilized in the creation of adhesives, enhancing their viscosity and adhesive properties.

The construction industry uses PVP K 90 solution 20% in cement formulations to improve workability and reduce water demand.
PVP K 90 solution 20% is found in the textile industry as a dye dispersant and for its film-forming properties in sizing agents.
PVP K 90 solution 20% is included in the formulation of paints and coatings, contributing to film formation and dispersing properties.

PVP K 90 solution 20% is employed in the creation of hydrogels for medical applications, such as wound dressings and drug delivery systems.
PVP K 90 solution 20% is utilized in the paper industry to improve paper strength and reduce linting.
PVP K 90 solution 20% is part of the excipients used to improve the bioavailability of poorly water-soluble drugs.
In the agricultural sector, PVP is used in crop protection formulations, ensuring the uniform distribution of active ingredients.

PVP K 90 solution 20% is employed in the production of specialty inks for screen printing, ensuring durability and adhesion on various surfaces.
In the agricultural sector, PVP is included in seed coatings to improve germination rates and protect seeds from environmental stress.
The cosmetic industry uses PVP K 90 solution 20% in the creation of nail polishes for its film-forming and adhesive properties.

PVP K 90 solution 20% is found in the formulation of detergents and cleaning products, improving stability and viscosity.
PVP K 90 solution 20% is used in the creation of adhesives for postage stamps, ensuring secure bonding and adhesion to envelopes.

PVP K 90 solution 20% is included in the formulation of smoke-generating formulations for firefighting training exercises and signaling devices.
In the printing industry, PVP is utilized as a binder in ink formulations, improving adhesion to various surfaces.
PVP K 90 solution 20% is employed in the manufacturing of photographic emulsions as a protective colloid for the dispersion of light-sensitive silver halide crystals.

The semiconductor industry uses PVP in the production of photoresists, facilitating the patterning process in microfabrication.
PVP K 90 solution 20% is utilized in the formulation of lubricating eye drops, providing comfort and moisture to dry eyes.
In the production of ophthalmic solutions, PVP is used as a stabilizer to maintain the clarity and stability of the solution.

PVP K 90 solution 20% is found in the formulation of fuel additives, where it acts as a dispersant to prevent the formation of deposits in engines.
The textile industry uses PVP in sizing agents to improve fiber cohesion and reduce yarn breakage during weaving.
PVP K 90 solution 20% is employed in the creation of chromatography resins, aiding in the separation of biomolecules in bioprocessing.
In the manufacturing of ion exchange resins, PVP contributes to their stability and ion absorption capabilities.

PVP K 90 solution 20% is included in the formulation of wound sealants, providing a protective barrier and promoting tissue adhesion.
PVP K 90 solution 20% is utilized in the development of air fresheners and deodorizing products for its ability to encapsulate and release fragrances.
PVP K 90 solution 20% is found in the formulation of hydrogels for medical applications, such as wound dressings and drug delivery systems.

PVP K 90 solution 20% is employed in the creation of antistatic coatings for plastics and textiles, helping prevent the buildup of static electricity.
The paint and coatings industry uses PVP as a thickening agent, enhancing the viscosity and application properties of coatings.
PVP K 90 solution 20% is included in the formulation of imaging agents for medical diagnostic purposes, improving contrast in imaging techniques.

In the production of ceramics, PVP serves as a binder, contributing to the green strength of molded ceramic articles.
PVP K 90 solution 20% is utilized in the creation of anti-aging skincare products, contributing to the texture and effectiveness of the formulations.
The creation of anti-fog coatings for eyeglasses and camera lenses involves the use of PVP for its film-forming properties.
PVP K 90 solution 20% is continuously explored for emerging applications, showcasing its adaptability and versatility in various industries.

PVP K 90 solution 20% is employed in the production of photovoltaic devices to improve the stability and efficiency of perovskite solar cells.
The cosmetic industry utilizes PVP K 90 solution 20% in the creation of hair care products like shampoos and conditioners for its conditioning and film-forming properties.

In the formulation of battery electrolytes, PVP is used to contribute to the stability and performance of the electrolyte solution.
PVP K 90 solution 20% is included in the production of latex gloves, where it serves as a coating agent to facilitate easy donning and doffing.
PVP K 90 solution 20% is used in the formulation of antifreeze products, aiding in the prevention of scale and corrosion in cooling systems.

PVP K 90 solution 20% is found in the creation of film coatings for pharmaceutical tablets, providing a protective and aesthetically pleasing layer.
The semiconductor industry employs PVP K 90 solution 20% in the production of inkjet inks to enhance color stability and prevent clogging of printheads.
In the agricultural sector, PVP is included in crop protection formulations to ensure the uniform distribution of active ingredients.

PVP K 90 solution 20% is used in the manufacturing of imaging agents for medical diagnostic purposes, improving contrast in imaging techniques.
The construction industry utilizes PVP in the production of concrete admixtures to improve workability and reduce water demand.

PVP K 90 solution 20% is part of the formulation of antistatic coatings for plastics and textiles, preventing the buildup of static electricity.
The creation of hydrogels for medical applications, such as wound dressings and drug delivery systems, involves the use of PVP.
PVP K 90 solution 20% is utilized in the development of inkjet inks to enhance color stability and prevent nozzle clogging.

The production of firefighting foam involves the use of PVP as a stabilizing agent for the foam.
PVP K 90 solution 20% is included in the creation of adhesives for specialty applications, such as postage stamps and specialty packaging.
The textile industry uses PVP as a dye carrier, improving color uniformity in dyeing processes.

PVP K 90 solution 20% is employed in the formulation of detergents and cleaning products, improving stability and viscosity.
In the manufacturing of ion exchange resins, PVP contributes to their stability and ion absorption capabilities.

PVP K 90 solution 20% is used in the formulation of air fresheners and deodorizing products for its ability to encapsulate and release fragrances.
PVP K 90 solution 20% is found in the production of firefighting training exercises, where it contributes to the formulation of smoke-generating formulations.
In the creation of antifog coatings for eyeglasses and camera lenses, PVP is used for its film-forming properties.

The semiconductor industry employs PVP in the production of photoresists, facilitating the patterning process in microfabrication.
PVP K 90 solution 20% is included in the formulation of wound care products like adhesive tapes, providing secure and comfortable adhesion.
The cosmetic industry utilizes PVP K 90 solution 20% in the formulation of specialty inks for screen printing, ensuring durability and adhesion.
PVP K 90 solution 20% is continually explored for emerging applications, showcasing its adaptability and versatility in various industries.



DESCRIPTION


PVP K90 (Polyvinylpyrrolidone K90) solution 20% is a liquid formulation containing 20% Polyvinylpyrrolidone with a specific average molecular weight, commonly known as PVP K90.
PVP K 90 solution 20% is a water-soluble polymer derived from the polymerization of vinylpyrrolidone monomers.

In the context of PVP K90 solution 20%, the "20%" indicates the concentration of the PVP K90 polymer in the solution.
It means that 20% of the solution's total weight is composed of PVP K90, while the remaining 80% typically consists of water.
The specific properties and applications of the solution depend on the concentration and molecular weight of the PVP K90 used.

PVP K 90 solution 20% is a versatile polymer with various applications in industries such as pharmaceuticals, cosmetics, personal care, and others.
Its properties, including water solubility, film-forming capabilities, and biocompatibility, make it valuable in formulations for different purposes.
The 20% solution format allows for easy incorporation into formulations without the need for additional dissolution steps.

PVP K 90 solution 20% is a versatile water-soluble polymer widely used in various industries.
PVP K 90 solution 20% is known for its exceptional solubility in water, producing clear and colorless solutions.

PVP K 90 solution 20% is derived from the polymerization of vinylpyrrolidone monomers.
PVP K 90 solution 20% has film-forming properties, making it valuable in coatings and pharmaceutical applications.
The chemical structure of PVP consists of repeating units of 1-ethenyl-2-pyrrolidinone.
PVP K 90 solution 20% is biocompatible and widely employed in pharmaceuticals, cosmetics, and personal care products.

PVP K 90 solution 20% exhibits hygroscopic behavior, absorbing and retaining moisture from the environment.
PVP K 90 solution 20% is often used as a stabilizing agent, contributing to the shelf life of certain formulations.
In the pharmaceutical industry, different grades like PVP K30 and PVP K90 offer specific molecular weight ranges.

PVP K 90 solution 20% serves as a binder in tablet formulations, enhancing their cohesion and disintegration properties.
PVP K 90 solution 20% finds application in oral care products, contributing to stability and consistency in mouthwashes and toothpaste.
PVP K 90 solution 20%'s film-forming characteristics make it beneficial in cosmetic formulations, including hairsprays.

As a disintegrant in tablets, PVP aids in the quick disintegration of pharmaceuticals in the digestive system.
PVP K 90 solution 20% is used in the production of fast-dissolving oral films, improving drug delivery.
PVP K 90 solution 20% is employed as a stabilizing agent in ointments, creams, and gels in the pharmaceutical and cosmetic industries.
PVP K 90 solution 20% iodine complex serves as an antiseptic in various healthcare and first aid products.

PVP K 90 solution 20% is utilized in transdermal drug delivery systems for controlled release applications.
PVP K 90 solution 20% contributes to the clarity and stability of solutions in ophthalmic and contact lens products.

In the food industry, PVP clarifies beverages and aids in the removal of haze-forming substances.
PVP K 90 solution 20% is a common ingredient in the production of specialty coatings for pharmaceutical tablets.

Its hygroscopic nature makes PVP suitable for formulations requiring moisture retention.
The cosmetic industry utilizes PVP in various products, such as mascaras, for its film-forming properties.
PVP K 90 solution 20% is employed in the creation of adhesives, contributing to their viscosity and bonding strength.

PVP K 90 solution 20%'s water solubility allows for easy incorporation into a variety of aqueous formulations.
PVP K 90 solution 20% continues to be an essential component in a wide range of applications due to its diverse and beneficial properties.



PROPERTIES


Chemical Formula: (C6H9NO)n, where n represents the number of repeating units in the polymer chain.
Molecular Weight: Varies depending on the specific grade of PVP (e.g., PVP K30, PVP K90).
Chemical Structure: Consists of repeating units of 1-ethenyl-2-pyrrolidinone.
CAS Number: 9003-39-8.
Solubility: Highly soluble in water, forming clear and colorless solutions.
Appearance: Typically white or off-white powder or solid.
Odor: Generally odorless.
Melting Point: Decomposes before reaching a specific melting point.
Boiling Point: Decomposes under high temperatures.
Density: Varies depending on the molecular weight and specific form of Povidone.
pH: PVP solutions are typically neutral.
Hygroscopicity: Exhibits hygroscopic behavior, absorbing and retaining moisture from the environment.
Film-Forming: Possesses film-forming properties, contributing to its use in various coatings and applications.
Biocompatibility: Generally considered biocompatible and safe for use in pharmaceuticals and medical applications.
Stability: Stable under normal storage conditions but may be affected by extreme temperatures and humidity.
Viscosity: The viscosity of PVP solutions can be adjusted based on concentration.
Compatibility: Compatible with a wide range of other substances, including drugs, polymers, and cosmetic ingredients.
Refractive Index: Varies depending on the molecular weight and concentration of the PVP solution.
Flash Point: Not applicable as it is not a flammable substance.



FIRST AID


Inhalation:

If PVP dust or aerosol is inhaled and respiratory discomfort occurs, move the affected person to an area with fresh air.
If breathing difficulties persist, seek medical attention.
Provide respiratory support if necessary, such as administering oxygen by a trained professional.


Skin Contact:

In case of skin contact, promptly wash the affected area with soap and water.
Remove contaminated clothing and ensure thorough rinsing of the skin.
If irritation or allergic reactions occur, seek medical advice.
If there is a significant exposure, use appropriate protective clothing to prevent further contact.


Eye Contact:

If PVP comes into contact with the eyes, immediately flush the eyes with gently flowing water for at least 15 minutes, holding the eyelids open.
Seek medical attention if irritation persists or if there is any sign of injury.
Remove contact lenses, if applicable, after the initial eye rinse.


Ingestion:

If PVP is ingested accidentally, rinse the mouth with water.
Ingesting PVP is generally not harmful, but seek medical attention if there are concerns or if large amounts are ingested.
Do not induce vomiting unless instructed to do so by medical professionals.


General First Aid Measures:

If any adverse reactions, such as skin irritation or respiratory discomfort, occur after exposure to PVP, seek medical assistance promptly.
If seeking medical attention, provide healthcare professionals with details about the specific PVP product and the nature of exposure.
Be prepared to provide information on the concentration and form of PVP involved in the exposure.
If available, have the safety data sheet (SDS) or product information accessible for medical professionals.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including gloves and safety goggles, when handling PVP.
Use chemical-resistant gloves to minimize skin contact.
In case of prolonged or repeated exposure, consider wearing protective clothing.

Ventilation:
Work in a well-ventilated area or use local exhaust ventilation to control airborne concentrations.
If handling in an enclosed space, ensure proper ventilation systems are in place to minimize inhalation risks.

Avoidance of Contact:
Avoid direct skin and eye contact with PVP.
Take precautions to prevent inhalation of dust or aerosols.
Minimize exposure through the use of engineering controls and personal protective equipment.

Handling Procedures:
Follow good manufacturing and laboratory practices when working with PVP.
Use appropriate tools and equipment to minimize the generation of dust or aerosols during handling.

Spill Response:
In case of a spill, use suitable absorbent materials to contain and clean up the spilled substance.
Dispose of waste according to local regulations and in accordance with the product's safety data sheet (SDS).

Storage Compatibility:
Store PVP away from incompatible materials, such as strong acids, bases, and oxidizing agents.
Check compatibility with storage containers to prevent chemical reactions.

Labeling:
Ensure containers are properly labeled with the correct product information, hazard symbols, and safety precautions.
Maintain clear and visible labeling on secondary containers in case of transfer.


Storage:

Temperature:
Store PVP in a cool, dry place.
Avoid exposure to extreme temperatures, as excessive heat or cold may affect the stability of the substance.

Container Integrity:
Ensure that storage containers are tightly sealed to prevent contamination or evaporation.
Regularly inspect containers for any signs of damage or leaks.

Ventilation During Storage:
If stored in an enclosed area, provide adequate ventilation to prevent the accumulation of vapors.

Storage Conditions:
Store PVP in accordance with the manufacturer's recommendations.
Keep the substance away from direct sunlight and incompatible materials.

Separation from Food and Feed:
Store PVP away from food, beverages, and animal feed.
Use separate storage areas to avoid cross-contamination.

Handling Precautions:
Follow proper handling procedures when transferring PVP between containers or dispensing it for use.
Minimize the risk of spills during storage and handling.

Fire Prevention:
PVP is generally not flammable, but it's advisable to keep it away from open flames, sparks, or potential ignition sources.
Store in areas compliant with fire safety regulations.

Emergency Response:
Have appropriate emergency response equipment, such as spill containment materials and fire extinguishers, readily available.

Polyvinylpyrrolidone ;‘Plasdone’, PVP, Polyvidone, Povidone; POLYVINYLPYRROLIDONE K 30 cas no:9003-39-8

CAS NUMBER: 9003-39-8 Linear Formula (C6H9NO)n MDL number MFCD00149016 3D model (JSmol) Interactive image Abbreviations PVP, PVPP, NVP, PNVP ChEMBL ChEMBL1909074 ☒ ChemSpider none ECHA InfoCard 100.111.937 E number E1201 (additional chemicals) SMILES Properties Chemical formula (C6H9NO)n Molar mass 2,500 - 2,500,000 g·mol-1 Appearance white to light yellow, hygroscopic, amorphous powder Density 1.2 g/cm3 Melting point 150 to 180 °C (302 to 356 °F; 423 to 453 K) (glass temperature) Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Appearance (Colour) White to off - white Appearance (Form) Crystalline powder Solubility (Turbidity) 10% aq. solution Clear Nitrogen content (N) 11.5 - 12.5% pH (5% aq. solution) 3.0 - 7.0 Sulphated Ash max. 0.1% Heavy Metals (Pb) max. 0.001% K-value ~ 30 Vinyl pyrrolidone max. 0.8% Water (KF) max. 5% PVP K-30 is a hygroscopic, amorphous polyvinylpyrrolidone. Used in industrial, specialty and imaging coatings & paints and as a media component in digital ink jet-printing. Offers high polarity, dispersancy, hydrophilicity, adhesion, cohesivity and high glass transition temperature. PVP K-30 can be plasticized with water and most common organic plasticizers. They are linear nonionic polymers thar are soluble in water and organi solvents and are pH stable. PVP K-30 forms hard glossy transparent films and have adhesive, cohesive and dispersive properties. PVP K-30 100% Powder is soluble in water and many organic solvents and it forms hard, transparent, glossy film. PVP is compatible with most inorganic salts and many resins. PVP stabilizes emulsions, dispersions and suspensions. While PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-30 100% Powder appears as a white powder. Applications adhesives, ceramics, glass (fibers), coating/inks, electronic appliations, lithography and photography, fibers and textiles, membranes, metallurgy, paper, polymerizations, water and waste teratment, and hygiene. Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone: PVP was used as a plasma volume expander for trauma victims after the 1950s. It is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.) PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5] PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology[6] and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").[7] PVP is used as a lubricant in some eye drops, Soothe.[8] Technical PVP is also used in many technical applications: as an adhesive in glue stick and hot-melt adhesivesas a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process as an emulsifier and disintegrant for solution polymerization to increase resolution in photoresists for cathode ray tubes (CRT)[9] in aqueous metal quenching for production of membranes, such as dialysis and water purification filters as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating as a thickening agent in tooth whitening gels[10] as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation as an additive to Doro's RNA extraction buffer[citation needed] as a liquid-phase dispersion enhancing agent in DOSY NMR [11] as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12] as a stabilizing agent in all inorganic solar cells[13] Other uses PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP is useful for making an aqueous mounting medium.[16] PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17] Safety The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21] Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.[22][23] Properties PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.[26] History PVP was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production Vinylpyrrolidone polymer Polyvinylpyrrolidone is abbreviated as PVP, and is the polymer of vinylpyrrolidone. According to the different degree of polymerization, it is further classified into soluble PVP and insoluble PVPP (polyvinyl polypyrrolidone). Molecular weight of the soluble PVP is 8,000 to 10,000.The soluble PVP can be used as a precipitating agent which can be settle down through its action with polyphenols. Using this method, it is easily to have residual PVP in the alcohol. Due to the savings effect of PVP inside the human body, the World Health Organization doesn't recommend to apply this substance. In recent years, the use of soluble PVP has been rare. Insoluble PVPP system had began to be used in the beer industry since the early 1960s. It has a relative molecule weight greater than the relative mass greater than 700,000. It is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy. The molecular formula of Polyvinylpyrrolidone The molecular formula of Polyvinylpyrrolidone Polyvinylpyrrolidone PVP is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants. It is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents. Polyvinylpyrrolidone PVP and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent. The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust. Adopting different category of resin can meet various kinds of relative humidity climatic conditions. Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse. It can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo. Insoluble PVP is the stabilizer of beer and juice which can improve its transparency, color, and flavor. Water-soluble polyamides Polyvinyl pyrrolidone (PVP) is a water soluble polyamide. Commercially available PVP is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively. K value or molecular weight is an important factor which decides the various properties of PVP. Polyvinyl pyrrolidone (PVP) is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether. PVP used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7. PVP is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point. Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP's hygroscopicity and softness. PVP is not prone to have chemical reaction. Under normal storage conditions, dry PVP is quite stable. PVP has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic. Because of the hydrogen bonding or complexation effect, PVP's viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state. The dropping pill whose matrix is PVP can enhance the dissolution and bioavailability of poorly soluble drugs. In general, the greater the PVP amount, the higher dissolution and solubility of drug in the medium. Susana et al have studied the dissolution of the PVP solid dispersant of the slightly soluble drug albendazole. The increased amount of PVP (k30) can increase the dissolution rate and efficiency of drug inside the solid dispersant. Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in PVP solid dispersant and obtained similar conclusion. PVP also found that the higher the content, the more significant increase in dissolution. IR has showed that flunarizine and PVP has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the PVP. Tantishaiyakul et al has found that: when the ratio of piroxicam: PVP is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min. PVP can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix. The above information is edited by the Chemicalbook of Dai Xiongfeng. Physical and chemical properties Commonly used PVP level in the cosmetic industry is K-30. Commercialized PVP is white and free flowing powder or solids with its content in the mass fraction of 20%, 30%, 45% and 50% aqueous solution. PVP is soluble in water and is hygroscopic with a moisture equilibrium being 1/3 of the relative humidity of the environment. Similar as the protein hydration action, each monomer associates with 0.5mol water.Chart 1 and Chart 2 lists the reference quality standard of various types of polyvinylpyrrolidone PVP: Food grade and pharmaceutical grade polyvinylpyrrolidone PVP Chart 1: Food grade and pharmaceutical grade polyvinylpyrrolidone PVP Cosmetics and industrial polyvinylpyrrolidone PVP (Luvikol K, BASF) Chart 2: Cosmetics and industrial polyvinylpyrrolidone PVP (Luvikol K, BASF) PVP is not easy to have chemical reaction. When stored at normal conditions, dry PVP is quite stable. Solution undergone mildew treatment is also stable. When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, PVP will be exchanged to become a water-insoluble compound. In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP solution to become gel. The co-heating of PVP solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation. Many different compounds can generate complexes with PVP. For example, the complexes of PVP and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of PVP will generate insoluble complexes which are insoluble in water, alcohols and ketones. But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between PVP and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with PVP, which is the basis for using PVP as a dye bleaching agent. The use of polyvinylpyrrolidone In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP sprays which are still widely used until now. It can form wet, transparent film on the hair which is shiny and has good lubrication effect. PVP has good compatibility with a variety of good propellant and also has corrosion resistance. It is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer. PVP has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes. It is also used as toothpaste detergents, gelling agents and antidotes. The main drawback of PVP is its sensitivity to moisture. However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity. In addition, PVP also has wide application in the pharmaceutical, beverage and textile industries. Rheological properties of solutions Water and methanol is the preferred solvent of PVP. pH value has little effect on the viscosity of the aqueous solution of PVP, for example, at 25 °C, pH range: 0.1~10, aqueous solution of PVP K-30 with a mass fraction of 5% concentration has a viscosity of 2.3~2.4mPa • s; in concentrated hydrochloric acid, this is 4.96mPa • s. Effect of temperature on the viscosity of the PVP aqueous solution is also relatively not obvious. Un-cross-linked PVP solution is not particularly thixotropic unless under very high concentration and display a short relaxation time. The chart 3 below lists the viscosity of PVP K-30 in a variety of solvents. Viscosity of PVP K-30 in various organic solvents (w %) (At room temperature) Chart 3: Viscosity of PVP K-30 in various organic solvents (w %) (At room temperature) Reference: Edited by Binyi Qiu, "Compendium of cosmetic chemistry and technology" Volume 1 Beijing: China Light Industry Press, 1997. Compatibility Polyvinylpyrrolidone is mainly used as pharmaceutical excipient, blood compatibilizer, cosmetics thickening agents, latex stabilizers, and clarifying agent of beer brewing. Not matter whether in solution or in the form of film, PVP always has a high degree of compatibility. It has good compatibility with various kinds of inorganic salt solution, many natural and synthetic resins and other chemical compatibility. Examples of their compatibility are seen at chart 4 and Figure 5. The compatibility of PVP and some other substances in water and ethanol Chart 4: The compatibility of PVP and some other substances in water and ethanol The solubility and compatibility of PVP in various solvents Chart 5: The solubility and compatibility of PVP in various solvents Safety PVP is physiologically inert. Acute oral toxicity of PVP: LD50 > 100g/kg. It does not irritate the skin or eyes, do not cause skin allergies. A large number of long-term toxicology studies have confirmed that polyvinylpyrrolidone (PVP) can tolerate intraperitoneal, intramuscular, intravenous administration and parenteral applications. Subacute and chronic toxicity result was negative. Identification test Solubility: soluble in water, ethanol and chloroform and insoluble in ether. This is measured by the OT-42 method. Dichromate precipitation test: in 5 mL of2% sample solution, add 5 mL dilute hydrochloric acid solution (TS-117), further add 5 mL of water plus 2 mL of 10% potassium dichromate solution and 2ml. This should form an orange precipitate. Take 75 mg of cobalt nitrate and 300 mg of ammonium thiocyanate for being dissolved in 2ml of water; add 5 mL of 2% aqueous sample solution; after the mixing, add dilute hydrochloric acid test solution (TS-117) for acidification. This should form light blue precipitate. Take 5 mL of 2% sample solution; add 1 mL of 25% hydrochloric acid, 5 mL of 5% barium chloride and 1 mL 5% molybdenum tungsten phosphoric acid solution. This should generate a lot of white precipitate which gradually turns blue in the sunlight. The pH value of 5% sample solution should be 3.0 to 3.7. This is measured by conventional means. Adding a few drops of iodine test solution (TS-124) to 5 mL of 0.5% sample solution should produce a deep red color. Take 1 g of sample, add water to 10 ml as a suspension, add 0.1 mL of iodine test solution (TS-124), after mixing by shaking for 30s, iodine test solution should fade (to distinguish polyvinylpyrrolidone due to that polyvinylpyrrolidone can form red color). Add 1 mL of starch test solution (TS-235), after shaking and mixing, there should be no blue color formed. to produce blue. Content Analysis Estimated from the nitrogen content according to the following index of quality. Toxicity ADI 0~50 (FAO/WHO, 2001) LD50> 100g/kg (rat, oral). ADI does not make special provision (FAO/WHO, 2001). It is safe for food (FDA, §121.1110, §173.50, 2000). LD50:12g/kg (mice, abdominal injection). Limited use GB 2760-1996: beer GMP. Chemical Properties It is the cross-linked homopolymer of pure vinylpyrrolidone. It is hygroscopic and free-flowing white or off-white powder. It has a slight foul smell. It is insoluble in common solvents such as water, ethanol and ether. So its molecule weight range can't be measured. However, PVP has ability to form complex with various kinds of substances (such as "Hu" class substance which can lead to the discoloration of a variety of wines and beverages discoloration). Also it is easily to be removed after filtration because of its insolubility. Uses Clarifying agent; pigment stabilizer; colloidal stabilizer; It is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents. It is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L). Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; PVP of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine. Used as the fixing liquid for gas chromatography. It is used as a colloidal stabilizer and clarifying agent for beer clarification. Apply proper amount according the demands of production. It can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous. PolyFilterTM molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste. The products have two specifications: disposable type and regeneration type. Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since it is recyclable, it is suitable for large breweries for recycle application. In daily cosmetics, PVP and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye. Adding PVP to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect. Taking advantage of the excellent properties of PVP such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products. Production method Its crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction. Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h). The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product. Chemical Properties Hygroscopic, white or yellowish-white powder or flakes. Chemical Properties Povidone occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder. Povidones with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres. Povidone K-90 and higher K-value povidones are manufactured by drum drying and occur as plates. Uses suitable for gene delivery Definition ChEBI: A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group. Production Methods Povidone is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone. brand name Kollidon CL (BASF); Kollidon CLM (BASF); Polyplasdone (International Specialty Products);Acu-dyne;Adapettes;Adsorbobase;Adsovbotear;Agent at 717;Albigen a;Aldacol q;Amiorel eritro;Amyderm s;Andrestrac 2-10;Anexa;B 7509;Betaisod;Bridine;Clinidine;Final step;Frepp/sepp;Ganex p 804;Ga-pvp-101;Gyno-bidex;Isoplasma;Jodoplex;K 115;Kollidon 17;Kollidon 25;Kollidon 30;Kollidon 90;Kollidon ce 50/50;Kollidon k 25;Kollidon k 30;Luviskol k 17;Luviskol k 25;Luviskol k 30;Luviskol k 90;Luvisteol;Medicort;Molycu;Mundidon;Neojodin;Oftan flurekain;Peragal st;Periston-n-toxobin;Pevidine;Plasmadone;Plasmoid;Plassint;Podiodine;Polyclar at;Polyclar h;Polyclar l;Polyplasdone xl;Polyvidone-escupient;Polyvinyl pyrrolidone;Povadyne;Povidone k 29-32;Pvp 50;Pvp0;Pvp-k 15;Pvp-k 25;Pvp-k 30;Pvp-k 60;Pvp-k 90;Pvp-macrose;Pvp-macrox;Rocmuth;Sd 13;Soft-care;Tears plus;Venostasin retard;Vetedine;Yodiplexin. World Health Organization (WHO) Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears. General Description White powder. Compatible with a wide range of hydrophilic and hydrophobic resins. Air & Water Reactions Hygroscopic. Water soluble. Reactivity Profile Polyvinylpyrrolidone is a polymeric material and probably has low reactivity. Polyvinylpyrrolidone reacts as a weak base. Hazard Questionable carcinogen. Health Hazard SYMPTOMS: Polyvinylpyrrolidone may cause interstitial fibrosis in the lungs. Lesions regress when patient is no longer being exposed to the compound. Fire Hazard Flash point data for Polyvinylpyrrolidone are not available, but Polyvinylpyrrolidone is probably non-flammable. Pharmaceutical Applications Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms. In tableting, povidone solutions are used as binders in wet-granulation processes.Povidone is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms. Povidone solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads. Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions. The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone. Special grades of pyrogen-free povidone are available and have been used in parenteral formulations; Contact allergens Polyvinylpyrrolidone is widely used as is in cosmetics such as hair care products and in medical products. It acts as iodophor in iodine-polyvinylpyrrolidone. PVP is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten). It may cause type I contact urticaria or anaphylaxis. Safety Profile Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx. Safety Povidone has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran. Povidone is widely used as an excipient, particularly in oral tablets and solutions. When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.Povidone additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection. A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight. (mouse, IP): 12 g/kg storage Povidone darkens to some extent on heating at 150°C, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-130°C; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place. Purification Methods Purify it by dialysis, and freeze-drying. Also by precipitation from CHCl3 solution by pouring into ether. Dry it in a vacuum over P2O5. For the crosslinked polymer purification is by boiling for 10minutes in 10% HCl and then washing with glass-distilled water until free from Cl ions. Finally, Cl ions are removed more readily by neutralising with KOH and continued washing. Incompatibilities Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone. Traditional High-Efficient Rheology Modifier Carbomer Efficient Rheology Modifier For Home Care Traditional Long-Flow Property Carbomer Improved Type - Easy To Disperse Carbomer Improved Type -Self-Wetting Carbomer Improved Type Carbomer Liquid Carbomer Pharmaceutical Grade Carbomer Home Care Carbomer High Carlity Traditional Carbomer Benzen Free Carbomer Homopolymer Of Vinylpyrrolidone NM-PVP K-30 Chemical Name: Homopolymer of Vinylpyrrolidone CTFA Name :Polyvinylpyrrolidone NM-PVP K-30 can dissolve in water and grain alcohol, isopropyl alcohol or chloroform, but not in acetone or diethyl ether. Have good absorption moisture, film-forming, complex ability. It is a high performance, versatile polymer widely used in pharmaceutical field, cosmetics field, beer, water treatment membrane, detergents, paints and other fields. Application 1. Pharma application: Used as binder for tablet and pellet, dissolving assistant for injection, flowing assistant capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat sensitive drug. 2. Cosmetic application: Used extensively in a wide range hair care, skin care &oral care products. The products are particularly suitable for formulation where viscosity modification and film forming properties are required. 3. Tech application: As surface coating agent, dispersing agent, thickener, binder, porogen in water treatment membrane ( hollow fiber m

PVP/VA Copolymer; Poly(1-vinylpyrrolidone-co-Vinyl Acetate); Polectron 845; Luviskol VA 28I; Vinyl acetate-vinylpyrrolidone polymer; Vinylpyrrolidinone-vinyl acetate polymer CAS NO: 25086-89-9

Polyvinylpyrrolidone ;‘Plasdone’, PVP, Polyvidone, Povidone; POLYVINYLPYRROLIDONE K 90 cas no:9003-39-8

Povidone-Iodine is an iodophor solution containing a water-soluble complex of iodine and PVP K-90 (PVP) with broad microbicidal activity. Free iodine, slowly liberated from the polyvinylpyrrolidone iodine (PVPI) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow release of iodine from the PVPI complex in solution minimizes iodine toxicity towards mammalian cells.Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. WHEN GIVEN PARENTERALLY, UNEXCRETED PARTICLES ARE PHAGOCYTIZED BY CELLS OF RETICULOENDOTHELIAL SYSTEM & DEPOSITED IN STORAGE SITES IN LIVER, SPLEEN, LUNG, BONE MARROW...In 12 nonpregnant women, total iodine, protein-bound iodine, inorganic iodine, and thyroxine values were measured in serum before and 15, 30, 45 or 60 minutes after a two-minute vaginal disinfection with povidone-iodine (Betadine). Only 15 minutes after application, serum iodine levels were raised and remained significantly elevated 30, 45 and 60 minutes after disinfection. Serum concentrations of total iodine and inorganic iodine were increased up to fivefold to 15-fold, respectively; during the relative short period of observation, thyroxine levels were not altered.The disposition of N-[14C]-vinyl-2-pyrrolidone has been studied in male Sprague-Dawley rats following a single iv injection. ...Up to 6 hr after dosing, the highest tissue concentrations of radioactivity were found in the liver and small intestines. By that time, about 19% of the dose had been excreted in bile, yet, by 12 hr, only about 0.4% had been excreted in feces while about 75% had been excreted in urine. Thus, there appeared to be substantial enterohepatic recirculation of biliary metabolites. Very small quantities of the administered material were excreted unchanged. In a single rat, 12% of the urinary radioactivity was present as acetic acid. Other metabolites were not identified.Following ingestion /1-vinyl-2-pyrrolidinone/ is mainly distributed in the liver and small intestine. It is partially excreted in the urine in an acetate form, but it is mostly (88%) combined with water-soluble acid compounds. Following iv injection, 14C-1-vinyl-2-pyrrolidinone was cleared from the blood with a half-life of about 2 hr. Unchanged /1-vinyl-2-pyrrolidinone/ accounted for <0.6% of the dose administered.The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing... . Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while 18.7% was excreted into the bile by 6 hours. 14C-activity attributed to the intact compound was found to be <0.59% of the dose in the urine and <0.46% in the bile. Tissue distribution studies showed that the liver and small intestines and contents contained the highest accumulation of 14C-activity up to 6 hours after administration of N-[14C-vinyl]-2-pyrrolidinone. Urine analyses performed for metabolite elucidation indicated that 12% of the radioactivity dosed was incorporated into acetate and the major remaining portion in species which appeared to be water soluble acidic compounds.The toxic effects of vinylpyrrolidone /and/ vinylacetate (VP-VA) were examined in rats. Female Wistar-rats, under ether narcosis, were given endotracheally 0.5 mL of a standard solution of VP-VA (10 g in 15 mL of physiological sodium-chloride solution). Other rats received up to 7 times the 2 mL standard solution daily under the skin of the back; between 1.1 and 45.0 g/kg VP-VA were injected. The animals were sacrificed between 1 and 365 days following the application of the VP-VA solution. Tissues were stained and examined by electron microscopy. One to 2 days after endotracheal injection, the alveoli were closely packed with macrophages. Four to 6 months after the last injection, there was still VP-VA in the lungs with the attendent macrophages. Animals killed 1 yr after the last injection showed no VP-VA in the lungs. After sc injection, most of the VP-VA was stored in the spleen. There were occasional, large macrophages found in the interstitial tissue of the lung. During the 1 yr period of observation, there was no evidence of tumors or systemic disease.PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-90 100% Powder appears as a white powder. PVP K-90 is a component of Denhardt's Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution. PVP K-90 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. PVP K-90 can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.Dispersancy, where components in a mixture are uniformly distributed through the use of PVP K-90.Hydrophilicity, where the substantial water solubility of PVP K-90 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.Adhesion, taking advantage of the higher molecular weight PVP K-90s formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.PVP K-90 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. acts as rheology modifier. is a highly adhesive tablet binder. stabilizes emulsion and structures liquid products. provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition. functions as binder and protective coating for enzymes. provides surface shine enhancement. forms hard, transparent, glossy films.PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-90 100% Powder appears as a white powder. PVP K-90 is a component of Denhardt's Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution. PVP K-90 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. PVP K-90 can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.Dispersancy, where components in a mixture are uniformly distributed through the use of PVP K-90.Hydrophilicity, where the substantial water solubility of PVP K-90 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.Adhesion, taking advantage of the higher molecular weight PVP K-90s formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.PVP K-90 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. acts as rheology modifier. is a highly adhesive tablet binder. stabilizes emulsion and structures liquid products. provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition. functions as binder and protective coating for enzymes. provides surface shine enhancement. forms hard, transparent, glossy films.PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-90 100% Powder appears as a white powder. PVP K-90 is a component of Denhardt's Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution. PVP K-90 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. PVP K-90 can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.Dispersancy, where components in a mixture are uniformly distributed through the use of PVP K-90.Hydrophilicity, where the substantial water solubility of PVP K-90 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.Adhesion, taking advantage of the higher molecular weight PVP K-90s formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.PVP K-90 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. acts as rheology modifier. is a highly adhesive tablet binder. stabilizes emulsion and structures liquid products. provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition. functions as binder and protective coating for enzymes. provides surface shine enhancement. forms hard, transparent, glossy films. Povidone-Iodine is an iodophor solution containing a water-soluble complex of iodine and PVP K-90 (PVP) with broad microbicidal activity. Free iodine, slowly liberated from the polyvinylpyrrolidone iodine (PVPI) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow release of iodine from the PVPI complex in solution minimizes iodine toxicity towards mammalian cells.Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. WHEN GIVEN PARENTERALLY, UNEXCRETED PARTICLES ARE PHAGOCYTIZED BY CELLS OF RETICULOENDOTHELIAL SYSTEM & DEPOSITED IN STORAGE SITES IN LIVER, SPLEEN, LUNG, BONE MARROW...In 12 nonpregnant women, total iodine, protein-bound iodine, inorganic iodine, and thyroxine values were measured in serum before and 15, 30, 45 or 60 minutes after a two-minute vaginal disinfection with povidone-iodine (Betadine). Only 15 minutes after application, serum iodine levels were raised and remained significantly elevated 30, 45 and 60 minutes after disinfection. Serum concentrations of total iodine and inorganic iodine were increased up to fivefold to 15-fold, respectively; during the relative short period of observation, thyroxine levels were not altered.The disposition of N-[14C]-vinyl-2-pyrrolidone has been studied in male Sprague-Dawley rats following a single iv injection. ...Up to 6 hr after dosing, the highest tissue concentrations of radioactivity were found in the liver and small intestines. By that time, about 19% of the dose had been excreted in bile, yet, by 12 hr, only about 0.4% had been excreted in feces while about 75% had been excreted in urine. Thus, there appeared to be substantial enterohepatic recirculation of biliary metabolites. Very small quantities of the administered material were excreted unchanged. In a single rat, 12% of the urinary radioactivity was present as acetic acid. Other metabolites were not identified.Following ingestion /1-vinyl-2-pyrrolidinone/ is mainly distributed in the liver and small intestine. It is partially excreted in the urine in an acetate form, but it is mostly (88%) combined with water-soluble acid compounds. Following iv injection, 14C-1-vinyl-2-pyrrolidinone was cleared from the blood with a half-life of about 2 hr. Unchanged /1-vinyl-2-pyrrolidinone/ accounted for <0.6% of the dose administered.The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing... . Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while 18.7% was excreted into the bile by 6 hours. 14C-activity attributed to the intact compound was found to be <0.59% of the dose in the urine and <0.46% in the bile. Tissue distribution studies showed that the liver and small intestines and contents contained the highest accumulation of 14C-activity up to 6 hours after administration of N-[14C-vinyl]-2-pyrrolidinone. Urine analyses performed for metabolite elucidation indicated that 12% of the radioactivity dosed was incorporated into acetate and the major remaining portion in species which appeared to be water soluble acidic compounds.The toxic effects of vinylpyrrolidone /and/ vinylacetate (VP-VA) were examined in rats. Female Wistar-rats, under ether narcosis, were given endotracheally 0.5 mL of a standard solution of VP-VA (10 g in 15 mL of physiological sodium-chloride solution). Other rats received up to 7 times the 2 mL standard solution daily under the skin of the back; between 1.1 and 45.0 g/kg VP-VA were injected. The animals were sacrificed between 1 and 365 days following the application of the VP-VA solution. Tissues were stained and examined by electron microscopy. One to 2 days after endotracheal injection, the alveoli were closely packed with macrophages. Four to 6 months after the last injection, there was still VP-VA in the lungs with the attendent macrophages. Animals killed 1 yr after the last injection showed no VP-VA in the lungs. After sc injection, most of the VP-VA was stored in the spleen. There were occasional, large macrophages found in the interstitial tissue of the lung. During the 1 yr period of observation, there was no evidence of tumors or systemic disease.PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-90 100% Powder appears as a white powder. PVP K-90 is a component of Denhardt's Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution. PVP K-90 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. PVP K-90 can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.Dispersancy, where components in a mixture are uniformly distributed through the use of PVP K-90.Hydrophilicity, where the substantial water solubility of PVP K-90 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.Adhesion, taking advantage of the higher molecular weight PVP K-90s formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.PVP K-90 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. acts as rheology modifier. is a highly adhesive tablet binder. stabilizes emulsion and structures liquid products. provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition. functions as binder and protective coating for enzymes. provides surface shine enhancement. forms hard, transparent, glossy films.PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-90 100% Powder appears as a white powder. PVP K-90 is a component of Denhardt's Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution. PVP K-90 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. PVP K-90 can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.Dispersancy, where components in a mixture are uniformly distributed through the use of PVP K-90.Hydrophilicity, where the substantial water solubility of PVP K-90 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.Adhesion, taking advantage of the higher molecular weight PVP K-90s formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.PVP K-90 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. acts as rheology modifier. is a highly adhesive tablet binder. stabilizes emulsion and structures liquid products. provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition. functions as binder and protective coating for enzymes. provides surface shine enhancement. forms hard, transparent, glossy films.PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-90 100% Powder appears as a white powder. PVP K-90 is a component of Denhardt's Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution. PVP K-90 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. PVP K-90 can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert. Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.Dispersancy, where components in a mixture are uniformly distributed through the use of PVP K-90.Hydrophilicity, where the substantial water solubility of PVP K-90 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.Adhesion, taking advantage of the higher molecular weight PVP K-90s formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.PVP K-90 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry. acts as rheology modifier. is a highly adhesive tablet binder. stabilizes emulsion and structures liquid products. provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition. functions as binder and protective coating for enzymes. provides surface shine enhancement. forms hard, transparent, glossy films.

PVP VA 64 is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.
The vinyl acetate component of PVP VA 64 reduces the hydrophilicity and glass transition temperature (Tg) compared to povidone homopolymers of similar molecular weight.
As a result, PVP VA 64 is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.

CAS: 25086-89-9
MF: C10H15NO3
MW: 197.23

Due to its spherical, hollow particle morphology and high plasticity, PVP VA 64 performs exceptionally well as a binder for direct compression.
In addition, a lower Tg makes PVP VA 64 an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, which enhances the dissolution of poorly soluble drug actives.
PVP VA 64 is used widely in pharmaceutical formulations and is generally regarded as nontoxic.
However, PVP VA 64 is moderately toxic by ingestion, producing gastric disturbances.
PVP VA 64 has no irritating or sensitizing effects on the skin.

A study was conducted to look at the carcinogenicity and chronic toxicity of PVP VA 64 (Kollidon VA 64) in Wistar rats and Beagle dogs.
The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.

PVP VA 64 copolymer functions as a binder, film former and hair fixative in cosmetic products.
PVP VA 64 is a more important ingredient from a formulation than a skincare standpoint.
As a binding agent, PVP VA 64 helps to bind or hold together the ingredients of a cosmetic product in the form of a compressed cake or tablet of a product.

Ingredients in dry form are mixed using a minimal amount of binder and then compressed to the desired effect.
This method prevents other ingredients in the product from breaking down.
As a film-forming agent, when applied to hair or skin, they form a continuous, cohesive, flexible layer.

This layer/film has water retention properties that leave a silky smooth effect on the skin. PVP VA 64 is also used in hair sprays and gels.
When used, PVP VA 64 forms a thin layer or film on the surface of the hair.
Considering its structure, PVP VA 64 also has several chemical groups that form temporary bonds that not only help to form a film, but also help to attach to the hair shaft and maintain the hairstyle.
PVP VA 64 prevents the hair from absorbing moisture and helps you maintain the style.
PVP VA 64 is used in formulas for styling products and other hair care products.

Benefits:
Suitability for use in direct compression, dry granulation, wet granulation, hot melt extrusion, and film coating,
Good flowability,
Large surface area due to hollow particle morphology – enhances particle bonding and good compressibility,
Ideal glass transition temperature (Tg) for hot melt extrusion.

PVP VA 64 Chemical Properties
Density: 1.27 g/mL at 25 °C(lit.)
Refractive index: 1.4300 to 1.4380
Fp: 72 °F
Solubility: Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water.
Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
Form: powder
Color: White
Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
LogP: 0.370 (est)
EPA Substance Registry System: PVP VA 64 (25086-89-9)

PVP VA 64 is a white to yellowish-white amorphous powder.
PVP VA 64 is typically spray-dried with a relatively fine particle size.
PVP VA 64 has a slight odor and a faint taste.

Uses
PVP VA 64 is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.

The main raw materials of cosmetics are used for hair gel, mousse, shampoo, etc., as well as surfactants, medicine and other industries.
PVP VA 64 mainly used as water-soluble adhesives and dry adhesives in granulation and direct tabletting technology, as film-forming materials in film coating, and as pore forming materials in flavoring agents.
PVP VA 64 is applied to sugar coating to prevent lobes, and the bottom coating is used to prevent moisture.

PVP VA 64 copolymer series products are mainly used as film forming agents and shaping agents in the field of cosmetics, especially in hair spray, hair spray, mousse and shampoo series products.
They play an important role as film-forming agents and hair styling agents.
If they are used in conjunction with PVP K30, they will enhance their use effect.

Production Methods
PVP VA 64 is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4.
The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.

Pharmaceutical Applications
PVP VA 64 is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations.
In tableting, PVP VA 64 can be used as a binder for direct compression and as a binder in wet granulation.
PVP VA 64 is often added to coating solutions as a film-forming agent.
PVP VA 64 provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

Synonyms
25086-89-9
Polectron 845
Luviskol VA 28I
Luviskol VA 37E
Luviskol VA 64
Kolima 10
Kolima 35
ethenyl acetate;1-ethenylpyrrolidin-2-one
Gantron S 860
PVP-VA
Ganex E 535
GAF-S 630
Luviskol VA 281
Luviskol VA 28 I
Luviskol VA 37 E
I 535
I 635
I 735
S 630
MFCD00134018
Luviskol VA-64
SCHEMBL29127
Copovidone (Technical Grade)
vinylpyrrolidone/vinyl acetate
Vinyl Pyrrolidone/Vinyl Acetate
N-vinylpyrrolidone/vinyl acetate
1-vinylpyrrolidone vinyl acetate
BCP31918
NSC114023
NSC114024
NSC114025
NSC114026
AKOS015898247
NSC-114023
NSC-114024
NSC-114025
NSC-114026
1-ethenylpyrrolidin-2-one; ethenyl acetate
ethenyl ethanoate; 1-ethenylpyrrolidin-2-one
FT-0659810
A817635
acetic acid ethenyl ester; 1-ethenyl-2-pyrrolidinone
733045-73-3

PVP VA 64 is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.
The vinyl acetate component of PVP VA 64 reduces the hydrophilicity and glass transition temperature (Tg) compared to povidone homopolymers of similar molecular weight.
As a result, PVP VA 64 is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.

CAS: 25086-89-9
MF: C10H15NO3
MW: 197.23

Due to its spherical, hollow particle morphology and high plasticity, PVP VA 64 performs exceptionally well as a binder for direct compression.
In addition, a lower Tg makes PVP VA 64 an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, which enhances the dissolution of poorly soluble drug actives.
PVP VA 64 is used widely in pharmaceutical formulations and is generally regarded as nontoxic.
However, PVP VA 64 is moderately toxic by ingestion, producing gastric disturbances.
PVP VA 64 has no irritating or sensitizing effects on the skin.

A study was conducted to look at the carcinogenicity and chronic toxicity of PVP VA 64 (Kollidon VA 64) in Wistar rats and Beagle dogs.
The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.

PVP VA 64 copolymer functions as a binder, film former and hair fixative in cosmetic products.
PVP VA 64 is a more important ingredient from a formulation than a skincare standpoint.
As a binding agent, PVP VA 64 helps to bind or hold together the ingredients of a cosmetic product in the form of a compressed cake or tablet of a product.

Ingredients in dry form are mixed using a minimal amount of binder and then compressed to the desired effect.
This method prevents other ingredients in the product from breaking down.
As a film-forming agent, when applied to hair or skin, they form a continuous, cohesive, flexible layer.

This layer/film has water retention properties that leave a silky smooth effect on the skin. PVP VA 64 is also used in hair sprays and gels.
When used, PVP VA 64 forms a thin layer or film on the surface of the hair.
Considering its structure, PVP VA 64 also has several chemical groups that form temporary bonds that not only help to form a film, but also help to attach to the hair shaft and maintain the hairstyle.
PVP VA 64 prevents the hair from absorbing moisture and helps you maintain the style.
PVP VA 64 is used in formulas for styling products and other hair care products.

Benefits:
Suitability for use in direct compression, dry granulation, wet granulation, hot melt extrusion, and film coating,
Good flowability,
Large surface area due to hollow particle morphology – enhances particle bonding and good compressibility,
Ideal glass transition temperature (Tg) for hot melt extrusion.

PVP VA 64 Chemical Properties
Density: 1.27 g/mL at 25 °C(lit.)
Refractive index: 1.4300 to 1.4380
Fp: 72 °F
Solubility: Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water.
Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
Form: powder
Color: White
Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
LogP: 0.370 (est)
EPA Substance Registry System: PVP VA 64 (25086-89-9)

PVP VA 64 is a white to yellowish-white amorphous powder.
PVP VA 64 is typically spray-dried with a relatively fine particle size.
PVP VA 64 has a slight odor and a faint taste.

Uses
PVP VA 64 is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.

The main raw materials of cosmetics are used for hair gel, mousse, shampoo, etc., as well as surfactants, medicine and other industries.
PVP VA 64 mainly used as water-soluble adhesives and dry adhesives in granulation and direct tabletting technology, as film-forming materials in film coating, and as pore forming materials in flavoring agents.
PVP VA 64 is applied to sugar coating to prevent lobes, and the bottom coating is used to prevent moisture.

PVP VA 64 copolymer series products are mainly used as film forming agents and shaping agents in the field of cosmetics, especially in hair spray, hair spray, mousse and shampoo series products.
They play an important role as film-forming agents and hair styling agents.
If they are used in conjunction with PVP K30, they will enhance their use effect.

Production Methods
PVP VA 64 is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4.
The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.

Pharmaceutical Applications
PVP VA 64 is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations.
In tableting, PVP VA 64 can be used as a binder for direct compression and as a binder in wet granulation.
PVP VA 64 is often added to coating solutions as a film-forming agent.
PVP VA 64 provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

Synonyms
25086-89-9
Polectron 845
Luviskol VA 28I
Luviskol VA 37E
Luviskol VA 64
Kolima 10
Kolima 35
ethenyl acetate;1-ethenylpyrrolidin-2-one
Gantron S 860
PVP-VA
Ganex E 535
GAF-S 630
Luviskol VA 281
Luviskol VA 28 I
Luviskol VA 37 E
I 535
I 635
I 735
S 630
MFCD00134018
Luviskol VA-64
SCHEMBL29127
Copovidone (Technical Grade)
vinylpyrrolidone/vinyl acetate
Vinyl Pyrrolidone/Vinyl Acetate
N-vinylpyrrolidone/vinyl acetate
1-vinylpyrrolidone vinyl acetate
BCP31918
NSC114023
NSC114024
NSC114025
NSC114026
AKOS015898247
NSC-114023
NSC-114024
NSC-114025
NSC-114026
1-ethenylpyrrolidin-2-one; ethenyl acetate
ethenyl ethanoate; 1-ethenylpyrrolidin-2-one
FT-0659810
A817635
acetic acid ethenyl ester; 1-ethenyl-2-pyrrolidinone
733045-73-3

DESCRIPTION:
PVP/VA 64 is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.
The vinyl acetate component of PVP/VA 64 reduces the hydrophilicity and glass transition temperature (Tg) compared to povidone homopolymers of similar molecular weight.
As a result, PVP/VA 64 is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.

CAS-No: 25086-89-9
INCI name: VP/VA Copolymer
Molecular Formula: (C6H9NO.C4H6O2)x

CHEMICAL AND PHYSICAL PROPERTIES OF PVP/VA 64:
Appearance : White – Cream Powder
K value(1% in ethanol): 26.0-34.0
Vinyl pyrrolidone: 60
Vinyl acetate: 40
pH (10% solution) 4-7
Solids content: 95%
Versatile film-formers for formulating of hair styling products.
Properties and differentiation are determined by the VP/VAratio in the polymer.
The series includes alcoholic (Ethanol, Isopropanol), aqueous and powder products.
•Medium to strong hold; Nonionic, no neutralization required
•Water-soluble or dispersable; Easy to wash out
•Non-forming; Easy to handle; Easy to comb out
•Compatible with ionic (anionic as well as cationic) additives
•Makes the hair shiny; Propane/butane compatibility 20-45%
•DME compatibility>70%

PVP/VA 64 is an easy-to-use aqueous solution that is compatible with carbomers, and is particularly suitable for alcohol-free formulations, forming a clear solution in water.
Due to its spherical, hollow particle morphology and high plasticity, PVP/VA 64 performs exceptionally well as a binder for direct compression.
In addition, a lower Tg makes PVP/VA 64 an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, which enhances the dissolution of poorly soluble drug actives.

PVP/VA 64 is a copolymer of vinylpyrrolidone with vinyl acetate in an an easy-to-use aqueous solution.
PVP/VA 64 is preserved with 0.05% max. dodecyl trimethyl ammonium chloride.
PVP/VA 64 is an excellent film-former and hair styling agent.

VP/VA copolymer.
PVP/VA 64 Acts as a film-forming agent and fixative in hair care.
PVP/VA 64 Is a copolymer of 1-vinyl-2-pyrrolidone & vinyl acetate in ratio of 60:40 in the form of powder.
PVP/VA 64 is Suitable for hair sprays and hair set lotion.

BENEFITS OF PVP/VA 64:
PVP/VA 64 is Suitable for use in direct compression, dry granulation, wet granulation, hot melt extrusion, and film coating.
PVP/VA 64 has Good flowability
PVP/VA 64 has Large surface area due to hollow particle morphology – enhances particle bonding and good compressibility
PVP/VA 64 has Ideal glass transition temperature (Tg) for hot melt extrusion.


FUNCTIONS OF PVP/VA 64:
• Binding.
• Film forming.
• Hair fixing.
• Viscosity controlling.


APPLICATIONS OF PVP/VA 64:
OF PVP/VA 64 İS Used in hair care like aerosol sprays, non-aerosol products, liquid hair setting products, gels and mousses.

RECOMMENDED DOSAGE:
The following concentrations are recommended (solids):
˗ Aerosol hair spray 2 - 6%
˗ Pump spray 3 - 7%
˗ Setting lotions 1 - 5%
˗ Setting mousse 1 - 5%
˗ Gels 1 - 5%
˗ Hair waxes 1 - 5%

STORAGE OF OF PVP/VA 64:
Store at a cool, dry and well ventilated place.

SAFETY INFORMATION ABOUT PVP/VA 64:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

Poly(1-vinylpyrrolidone-co-vinyl acetate); Copovidone; Poly(1-vinylpyrrolidone-co-Vinyl Acetate); Vinyl acetate-vinylpyrrolidone copolymer; PVP/VA Copolymer; Vinyl acetate-vinylpyrrolidinone polymer; Vinylpyrrolidinone-vinyl acetate polymer;

DESCRIPTION:
PVP/VA Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor.
So PVP/VA Copolymer is very common in most Hairsprays but also found in gel’s, wax’s, pomades and styling creams.
PVP/VA Copolymer is a synthetic ingredient that is derived from petroleum.

CAS NO.: 25086-89-9
Molecular Weight: 197.23415000
Formula:(C6H9NO) x (C4H6O2)y
CTFA NOMENCLATURE: PVP/VA copolymer


CHEMICAL AND PHYSICAL PROPERTIES OF PVP/VA COPOLYMER:
Solubility: Water (Heats accelerates hydration)
Use rate: 0.5 – 6.0% (Recommended use rate 3.0 – 5.0% for gels, creams, mousses and styling lotions)
Temperature tolerance: Avoid temperatures above 80°C
pH Stability: 4.0 – 7.0
Appearance: white to slightly yellowish, fine to coarse grained powder.
Assay: 60% VP (vinylpyrrolidone) / 40% VA (vinyl acetate) is available in powder form.
Storage: Store in a cool, dark, and dry place
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.95800 @ 25.00 °C.
Boiling Point: 217.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.132000 mmHg @ 25.00 °C. (est)
Flash Point: 72.00 °F. TCC ( 22.22 °C. )
logP (o/w): 0.370 (est)

PVP/VA (Also known as VP/VA), is a film forming agent that offers a strong, stiff hold in hair care.
PVP/VA Copolymer offers curl retention in high humidity.
PVP/VA Copolymer forms transparent, flexible, and breathable films

PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s.
PVP/VA Copolymer worked as a hairspray because it was soluble in water.
This meant PVP/VA Copolymer could be rinsed out when you wash your hair.
PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties.

PVP/VA Copolymer was fixed with the help of another polymer, a silicone called polydimethylsiloxane.
To understand how this silicone made a better hairspray, it helps to understand how the hairsprayworks in the first place.
When you spray PVP/VA Copolymer on, the polyvinylpyrrolidone forms a thin coating on the hair.
This coating is stiff and keeps the hair from moving around.
FEATURES OF PVP/VA COPOLYMER:
• Excellent curl retention
• Strong hold
• Transparency
• Anti-static
• Binding
• Emulsion stabilizing
• Film forming
• 60% VP (vinylpyrrolidone) / 40% VA (vinyl acetate) is available in powder form.


Pvp/va polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals.
Polyvinylpyrrolidone/vinyl acetate (pvp/va) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone.

Pvp/va copolymers are available as white powders or clear solutions in ethanol, isopropanol and water.
Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol.
The pvp/va copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions.


CHARACTERS:
In the form of powder, PVP/VA Copolymer is 50% aqueous solution or alcohol solution..
PVP/VA Copolymer is Able to form stiff, bright and washable film.
PVP/VA Copolymer is Soluble in most common organic solvents.

APPLICATIONS OF PVP/VA COPOLYMER:
PVP/VA Copolymer is used in Film-formers and stiffeners in hair care products.
PVP/VA Copolymer is used as Film formers in skin care preparations, suitable for eye and face dressings.

PVP/VA Copolymer is used as Rewettable Adhesives and adhesives for paper.
PVP/VA Copolymer is used as Thickeners and protective colloids for printing inks.
PVP/VA Copolymer is used as Dispersants and stabilizers for all kinds of suspensions and emulsions.

PVP/VA Copolymer is used in Hairsprays, mousses, coloring products, mousses, gels, styling lotions and conditioners.

What is PVP/VA COPOLYMER used for?
PVP/VA Copolymer has a number of benefits to offer in the world of cosmetics and personal care.
PVP/VA Copolymer can mainly be found in hair care products, followed by cosmetics and a few skin care products.

Skin care:
PVP/VA Copolymer is responsible for forming a thin layer on the skin that feels smooth to the touch and makes the surface look flawless.
PVP/VA Copolymer also retains moisture on the skin and doesn't allow it to run dry for longer durations of time.

Hair care:
PVP/VA Copolymer is mainly used in hair care products for hair setting.
PVP/VA Copolymer does not allow the shafts to absorb any further moisture and thus lose any styling done on them.
PVP/VA Copolymer also forms a thin coat on hair that helps them retain its shape.

Decorative cosmetics:
PVP/VA Copolymer is also added to cosmetic products like nail polish and mascara because it dries up to form a film that inhibits the surface from absorbing any moisture and thus keeps it styled impeccably.


ORIGIN OF PVP/VA COPOLYMER:
PVP/VA Copolymer is made by the monomers of vinylpyrrolidone and vinyl acetate.
PVP/VA Copolymer appears as a white free-flowing powder and is the result of very small chemical compounds combining to form a large molecule.


WHAT DOES PVP/VA COPOLYMER DO IN A FORMULATION?
• Film forming
• Hair fixing
• Moisturising

SAFETY PROFILE OF PVP/VA COPOLYMER:
PVP/VA Copolymer has been termed safe for use under the prescribed concentrations - any higher than that can cause side effects like irritation to the skin and scalp.
A patch test should be done before full usage.
Further, PVP/VA Copolymer is vegan.


SAFETY INFORMATION ABOUT PVP/VA COPOLYMER:

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

DESCRIPTION:
PVP/VA Copolymer is a film former produced by the free-radical polymerization on monomers in 70/30 VP/VA ratio.
PVP/VA Copolymer is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water.

CAS: 25086-89-9
European Community (EC) Number: 607-540-1
IUPAC Name: ethenyl acetate;1-ethenylpyrrolidin-2-one
Molecular Formula: C10H15NO3


SYNONYMS OF PVP/VA COPOLYMER:

Copovidone,Kollidon VA64,poly(V-co-V-Ac),poly(vinyl pyrrolidone-co-vinyl acetate),poly(vinylpyrrolidone-co-vinyl-acetate),polyvidone-vinylacetate 64,PVP VA64,PVP-VA,PVPVA 64,25086-89-9,PVP-VA,Polectron 845,Luviskol VA 28I,Luviskol VA 37E,Luviskol VA 64,Kolima 10,Kolima 35,ethenyl acetate;1-ethenylpyrrolidin-2-one,Gantron S 860,Ganex E 535,GAF-S 630,Luviskol VA 281,Luviskol VA 28 I,Luviskol VA 37 E,I 535,I 635,I 735,S 630,MFCD00134018,Copovidone (Technical Grade),Luviskol VA-64,SCHEMBL29127,vinylpyrrolidone/vinyl acetate,Vinyl Pyrrolidone/Vinyl Acetate,N-vinylpyrrolidone/vinyl acetate,1-vinylpyrrolidone vinyl acetate,FYUWIEKAVLOHSE-UHFFFAOYSA-N,BCP31918,NSC114023,NSC114024,NSC114025,NSC114026,AKOS015898247,NSC-114023,NSC-114024,NSC-114025,NSC-114026,1-ethenylpyrrolidin-2-one; ethenyl acetate,ethenyl ethanoate; 1-ethenylpyrrolidin-2-one,FT-0659810,A817635,acetic acid ethenyl ester; 1-ethenyl-2-pyrrolidinone,733045-73-3



PVP/VA Copolymer acts as a film forming agent.
PVP/VA Copolymer forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal.
PVP/VA Copolymer offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility.

PVP/VA Copolymer finds application in formulating hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers.
PVP/VA Copolymer is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in ethanol.
PVP/VA Copolymer is produced by the free-radical polymerization of monomers in the ratio of 70/30 (VP/VA).


PVP/VA Copolymer is a film forming ingredient that works well in both skin/hair care products and cosmetics.
PVP/VA Copolymer forms a film on the surface to trap and retain moisture for longer durations.

PVP/VA Copolymer is found primarily in most hair care products, mascaras, nail polishes and also some skin care products.
The full form of VP/VA Copolymer is vinylpyrrolidone/vinyl acetate copolymer, which appears as a white powder in its raw form.



FEATURES & BENEFITS OF PVP/VA COPOLYMER:
PVP/VA Copolymer is Strong, stiff hold
PVP/VA Copolymer has Enhanced high humidity curl retention

PVP/VA Copolymer is has Good propellant compatibility
PVP/VA Copolymer is Vegan suitable


CHEMICAL AND PHYSICAL PROPERTIES OF PVP/VA COPOLYMER:
Form: Aqueous viscous liquid
VP/VA Ratio: 70/30
50% solution in water
Color (APHA) - as is: 80 max.
K-Value (1% in EtOH): 25-34
Use Level: 0.5 - 6.0% solids
Primary Chemistry: VP/VA Copolymer
Molecular Weight
197.23 g/mol
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
197.10519334 g/mol
Monoisotopic Mass
197.10519334 g/mol
Topological Polar Surface Area
46.6Ų
Heavy Atom Count
14
Formal Charge
0
Complexity
186
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
2
Compound Is Canonicalized
Yes
SAFETY INFORMATION ABOUT PVP/VA COPOLYMER:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product

PVP/VA I-535 (Polyvinylpyrrolidone Vinyl Acetate) VP/VA Copolymer. PVP-VA I-535 acts as a film forming agent. PVP-VA I-535 is produced by the free-radical polymerization of monomers in the ratio of 50/50 (VP/VA). Shows good propellant compatibility. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. PVP-VA I-535 finds application in formulating hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. PVP-VA I-535 offers strong & stiff hold, enhanced high humidity curl retention. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is a film former produced by the free-radical polymerization on monomers in 70/30 VP/VA ratio. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. PVP/VA W-Series copolymers are linear, random copolymers produced by the free-radical polymerization of the monomers varying from 30/70 to 40/60 vinyl acetate (VA) to vinylpyrrolidone (VP), supplied in water. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. What is PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) Copolymer? PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal. The advantages of using PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E and I copolymer Series To fit many application areas, the E and I series of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) S copolymer PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) S-630 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W copolymers PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W-735 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-735 copolymer, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-535 copolymer and PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E- 335 copolymer. In general, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymer is less hygroscopic than PVP. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) S-630 copolymer is used as a binder to allow the aqueous processing of photoresists. Storage and handling PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E- and I-series To fit more application areas, the E- and I-series of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W copolymers PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W-735 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-735, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-535 and PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-335. In general, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is less hygroscopic than PVP. Abstract In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate)) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate), N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) used in industrial, specialty and imaging coatings, printing inks and paints. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene.[2] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives.[2] Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.[1] What is PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) Copolymer? PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below) Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E and I copolymer Series To fit many application areas, the E and I series of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-735, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Storage and handling PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E- and I-series To fit more application areas, the E- and I-series of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-735, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W copolymers PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W-735 is a 70/30 copolymer of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) and vinyl acetate supplied as a 50% solution in water. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) W-735 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-735, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-535 and PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) E-335. In general, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is less hygroscopic than PVP. Uses Medical PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.) PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Technical PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as an adhesive in glue stick and hot-melt adhesives PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as an emulsifier and disintegrant for solution polymerization PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in increase resolution in photoresists for cathode ray tubes (CRT)[9] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as a thickening agent in tooth whitening gels[10] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as an additive to Doro's RNA extraction buffer[citation needed] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as a liquid-phase dispersion enhancing agent in DOSY NMR [11] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is used in as a stabilizing agent in all inorganic solar cells[13] Other uses PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is useful for making an aqueous mounting medium.[16] PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17] Safety of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21] Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) instead.[22][23] Properties of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) and its oxidized hydrolyzate. History of PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. VP/VA Copolymer. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is a film former. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is produced by the free-radical polymerization of monomers in the ratio of 70/30 (VP/VA). PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate)) copolymer in water. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) is a film former produced by the free-radical polymerization on monomers in 70/30 VP/VA ratio. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. PVP/VA W-Series copolymers are linear, random copolymers produced by the free-radical polymerization of the monomers varying from 30/70 to 40/60 vinyl acetate (VA) to vinylpyrrolidone (VP), supplied in water. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA I-535 (polyvinylpyrrolidone vinyl acetate) copolymers

PVP/VA W-635 VP/VA Copolymer. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is a film former. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is produced by the free-radical polymerization of monomers in the ratio of 70/30 (VP/VA). PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) ) copolymer in water. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is a film former produced by the free-radical polymerization on monomers in 70/30 VP/VA ratio. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. PVP/VA W-Series copolymers are linear, random copolymers produced by the free-radical polymerization of the monomers varying from 30/70 to 40/60 vinyl acetate (VA) to vinylpyrrolidone (VP), supplied in water. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. What is PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) Copolymer? PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal. The advantages of using PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E and I copolymer Series To fit many application areas, the E and I series of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) S copolymer PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) S-630 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W copolymers PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W-735 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-735 copolymer, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-535 copolymer and PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E- 335 copolymer. In general, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymer is less hygroscopic than PVP. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) S-630 copolymer is used as a binder to allow the aqueous processing of photoresists. Storage and handling PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E- and I-series To fit more application areas, the E- and I-series of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W copolymers PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W-735 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-735, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-535 and PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-335. In general, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is less hygroscopic than PVP. Abstract In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) ) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) , N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) used in industrial, specialty and imaging coatings, printing inks and paints. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene.[2] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives.[2] Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.[1] What is PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) Copolymer? PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below) Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E and I copolymer Series To fit many application areas, the E and I series of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-735, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Storage and handling PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) ) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E- and I-series To fit more application areas, the E- and I-series of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-735, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W copolymers PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W-735 is a 70/30 copolymer of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) and vinyl acetate supplied as a 50% solution in water. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) W-735 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-735, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-535 and PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) E-335. In general, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is less hygroscopic than PVP. Uses Medical PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.) PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Technical PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as an adhesive in glue stick and hot-melt adhesives PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as an emulsifier and disintegrant for solution polymerization PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in increase resolution in photoresists for cathode ray tubes (CRT)[9] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as a thickening agent in tooth whitening gels[10] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as an additive to Doro's RNA extraction buffer[citation needed] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as a liquid-phase dispersion enhancing agent in DOSY NMR [11] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is used in as a stabilizing agent in all inorganic solar cells[13] Other uses PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is useful for making an aqueous mounting medium.[16] PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17] Safety of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21] Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) instead.[22][23] Properties of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. A 2014 study found fluorescent properties of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) and its oxidized hydrolyzate. History of PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP/VA W-635 (Polyvinylpyrrolidone Vinyl Acetate) was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.

PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate) VP/VA Copolymer. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is a film former. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is produced by the free-radical polymerization of monomers in the ratio of 70/30 (VP/VA). PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat)) copolymer in water. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is a film former produced by the free-radical polymerization on monomers in 70/30 VP/VA ratio. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. PVP/VA W-Series copolymers are linear, random copolymers produced by the free-radical polymerization of the monomers varying from 30/70 to 40/60 vinyl acetate (VA) to vinylpyrrolidone (VP), supplied in water. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. What is PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) Copolymer? PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations. Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal. The advantages of using PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers as film formers are: • film flexibility • good adhesion • water remoistenability • hardness These properties make PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates. • Linear, random copolymers • Increasing vinyl acetate content - increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg • Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals • Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50% • Adhesive and cohesive properties • E = ethanol (EtOH), I = isopropanol, W = water, S = solid The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E and I copolymer Series To fit many application areas, the E and I series of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) S copolymer PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) S-630 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W copolymers PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W-735 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution. VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer. Plasticizers and Polymers: Most PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-735 copolymer, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-535 copolymer and PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E- 335 copolymer. In general, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymer is less hygroscopic than PVP. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are widely used for their excellent film forming properties in the following applications and markets: In hot melt adhesives, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are used in a variety of water remoistenable or water removable adhesives as listed below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) S-630 copolymer is used as a binder to allow the aqueous processing of photoresists. Storage and handling PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E- and I-series To fit more application areas, the E- and I-series of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W copolymers PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W-735 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-735, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-535 and PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-335. In general, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is less hygroscopic than PVP. Abstract In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat)) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat), N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods. As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain. Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability. PVP/VA Copolymer. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) acts as a film forming agent. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. It offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water. It is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA). PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) thermoplastic, linear, random vinylpyrrolidone/vinylacetate copolymer. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) used in industrial, specialty and imaging coatings, printing inks and paints. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) provides transparency, flexibility, oxygen permeability and adhesion to glass, plastics and metals. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene.[2] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives.[2] Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.[1] What is PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) Copolymer? PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties. This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below) Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E and I copolymer Series To fit many application areas, the E and I series of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-735, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios. Storage and handling PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals. Polyvinylpyrrolidone/vinyl acetate (PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat)) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E- and I-series To fit more application areas, the E- and I-series of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-735, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties - water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA. The PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W copolymers PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W-735 is a 70/30 copolymer of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) and vinyl acetate supplied as a 50% solution in water. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) W-735 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair. Plasticizers and polymers: Most PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing. Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-735, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-535 and PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) E-335. In general, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is less hygroscopic than PVP. Uses Medical PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) was used as a plasma volume expander for trauma victims after the 1950s.It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.) PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Technical PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as an adhesive in glue stick and hot-melt adhesives PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as an emulsifier and disintegrant for solution polymerization PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in increase resolution in photoresists for cathode ray tubes (CRT)[9] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in aqueous metal quenching for production of membranes, such as dialysis and water purification filters PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as a thickening agent in tooth whitening gels[10] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as an additive to Doro's RNA extraction buffer[citation needed] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as a liquid-phase dispersion enhancing agent in DOSY NMR [11] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is used in as a stabilizing agent in all inorganic solar cells[13] Other uses PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some. As a food additive, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers. In molecular biology, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR. In microscopy, PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) is useful for making an aqueous mounting medium.[16] PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17] Safety of PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP/VA W-735 (Polyvinylpyrrolidone Vinyl Acetate, Polivinilpirolidon Vinil Asetat) component of the solution.[19] A woman, who had previ

PYRIDOXINE HCL, N° CAS : 58-56-0 / 12001-77-3 - Pyridoxine hydrochloride. Nom INCI : PYRIDOXINE HCL. Nom chimique : 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride, N° EINECS/ELINCS : 200-386-2 / -. Ses fonctions (INCI). Antistatique : Réduit l'électricité statique en neutralisant la charge électrique sur une surface. Conditionneur capillaire : Laisse les cheveux faciles à coiffer, souples, doux et brillants et / ou confèrent volume, légèreté et brillance. Agent d'entretien de la peau : Maintient la peau en bon état

DESCRIPTION:

PVP-VA E-535 acts as a film forming agent.
PVP-VA E-535 is produced by the free-radical polymerization of monomers in the ratio of 50/50 (VP/VA).

PVP-VA E-535 is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in ethanol.


CAS Number:64-17-5
European Community (EC) Number: 607-540-1
Molecular Formula: C10H15NO3
IUPAC Name: ethenyl acetate;1-ethenylpyrrolidin-2-one


SYNONYMS OF PVP-VA E-535:
Copovidone,Kollidon VA64,poly(V-co-V-Ac),poly(vinyl pyrrolidone-co-vinyl acetate),poly(vinylpyrrolidone-co-vinyl-acetate),polyvidone-vinylacetate 64,PVP VA64,PVP-VA,PVPVA 64,25086-89-9,PVP-VA,Polectron 845,Luviskol VA 28I,Luviskol VA 37E,Luviskol VA 64,Kolima 10,Kolima 35,ethenyl acetate;1-ethenylpyrrolidin-2-one,Gantron S 860,Ganex E 535,Copovidone (Technical Grade),GAF-S 630,Luviskol VA 281,Luviskol VA 28 I,Luviskol VA 37 E,I 535,I 635,I 735,S 630,MFCD00134018,Luviskol VA-64,SCHEMBL29127,vinylpyrrolidone/vinyl acetate,Vinyl Pyrrolidone/Vinyl Acetate,N-vinylpyrrolidone/vinyl acetate,1-vinylpyrrolidone vinyl acetate,BCP31918,NSC114023,NSC114024,NSC114025,NSC114026,AKOS015898247,NSC-114023,NSC-114024,NSC-114025,NSC-114026,1-ethenylpyrrolidin-2-one; ethenyl acetate,ethenyl ethanoate; 1-ethenylpyrrolidin-2-one,FT-0659810,50% in ethanol pound copolymer,3:7 pound(c),A817635,acetic acid ethenyl ester; 1-ethenyl-2-pyrrolidinone,733045-73-3

PVP-VA E-535 offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility.
PVP-VA E-535 forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal.
PVP-VA E-535 finds application in formulating hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers.


Series of copolymers covering a range of VP/VA ratios.
PVP/VA S-630 is a white powder while the others are 50% solutions in ethanol (E), isopropanol (I) or water (W).

PVP-VA I-535 by Ashland Specialty Chemical acts as a film forming agent.
PVP-VA E-535 is produced by the free-radical polymerization of monomers in the ratio of 50/50 (VP/VA).
PVP-VA E-535 Shows good propellant compatibility.

PVP-VA E-535 forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal.
PVP-VA I-535 finds application in formulating hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers.
PVP-VA E-535 offers strong & stiff hold, enhanced high humidity curl retention.



CHEMICAL AND PHYSICAL PROPERTIES OF PVP-VA E-535:
Molecular Weight
197.23 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Hydrogen Bond Donor Count
0
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Hydrogen Bond Acceptor Count
3
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Rotatable Bond Count
3
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Exact Mass
197.10519334 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Monoisotopic Mass
197.10519334 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Topological Polar Surface Area
46.6Ų
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Heavy Atom Count
14
Computed by PubChem
Formal Charge
0
Computed by PubChem
Complexity
186
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Isotope Atom Count
0
Computed by PubChem
Defined Atom Stereocenter Count
0
Computed by PubChem
Undefined Atom Stereocenter Count
0
Computed by PubChem
Defined Bond Stereocenter Count
0
Computed by PubChem
Undefined Bond Stereocenter Count
0
Computed by PubChem
Covalently-Bonded Unit Count
2
Computed by PubChem
Compound Is Canonicalized
Yes



SAFETY INFORMATION ABOUT PVP-VA E-535:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.