Punica Granataum Fruit or Flower or Seed Extract; punica granatum l. bark extract ;extract of the bark of the pomegranate, punica granatum l., punicaceae; pormegranate bark extract; punica florida bark extract; punica grandiflora bark extract; punica nana bark extract; punica spinosa bark extract cas no:84961-57-9

n-butyl alcohol; 1-Butyl alcohol; Butanolen; Butanol; Butan-1-ol; 1-Butan-1-ol; Butyl hydroxide; 1-Hydroxybutane; Methylolpropane; Propylcarbinol; Propylmethanol; Butylowy alkohol; Butyric alcohol; Propylmethanol; Nomal Butanol; cas no: 71-36-3

DESCRIPTION:

Natriquest E30 is a biodegradable chelating agent that is special in the fact that it is very selective towards problematic transition metals such as Cu and Fe compared to Ca and Mg.
Natriquest E30 is an unique readily biodegradable chelating agent.
Natriquest E30 is effective as a preservative potentiator and antioxidant with 37% active content in formulations.



CAS NUMBER: 178949-82

EC NUMBER: 416-530-4

MOLECULAR FORMULA: C10H16N2O8

MOLECULAR WEIGHT: 292.24 g/mol




DESCRIPTION:

This makes Natriquest E30 ideal in personal care formulations as it is tackling these problematic transition metals first while in the formulation, but still giving hard water control when released into water.
This gives Natriquest E30 the benefit of excellent anti-oxidant properties and foam preservation in shampoos and conditioners.
Natriquest E30 prevents discoloration and malodor and reduces the effect of water hardness.
Natriquest E30 is ideal for wash-off applications. Natrlquest® E30 is suitable for use in personal care products.

Natriquest E30 can complex a range of metal ions over a broad pH.
The maximum chelation occurs approximately in the centre of the pH range at around pH7 – that of water.
This gives Natriquest E30 the benefit of excellent anti-oxidant properties and foam preservation in shampoos and conditioners.
Natriquest E30 is a chelating agent commonly used in various industries, including pharmaceuticals, cosmetics, food, and cleaning products.
Natriquest E30 is derived from ethylenediamine, a compound that forms complexes with metal ions.

Natriquest E30 is a salt form of ethylenediamine tetraacetic acid (EDTA), which is a versatile chelating agent.
Natriquest E30 is specifically designed to bind and sequester metal ions such as calcium, magnesium, iron, and copper.
Natriquest E30 is commonly used in cleaning agents, detergents, and soaps to improve their performance by binding to metal ions that can interfere with the cleaning process.
Natriquest E30 helps to prevent the formation of deposits and improves the effectiveness of certain chemical reactions.

Natriquest E30 is often used as a stabilizer and preservative.
Natriquest E30 helps to maintain the stability and effectiveness of formulas by preventing the degradation of ingredients due to metal ion contamination.
Natriquest E30 is utilized in pharmaceutical formulations to enhance the stability and bioavailability of certain drugs.
Natriquest E30 can chelate metal ions that might otherwise cause degradation or inactivate the active pharmaceutical ingredient.

Natriquest E30 is used commercially in peroxide based products.
Natriquest E30 is much better, for instance, in stabilising peroxide against decomposition by iron compared with alternative biodegradable chelants.
Natriquest E30 is used to enhance the activity of preservatives in personal care formulations, improving efficacy and allowing the level to be reduced. Natrlquest E30 is not a preservative by itself.
Natriquest E30 is classed as readily biodegradable.

Natriquest E30 is chelating agent which binds with metal ions or metallic compounds
Natriquest E30 plays a pivotal role in the overall stability, aesthetics, and efficacy of the formulation
Natriquest E30 is commonly used in body washes, cleansers, and shampoos
Natriquest E30 comes in either solid or granular form as a raw material

Natriquest E30 is a chelating agent which is used in skin care/cosmetic formulations to bind with metal ions or metallic compounds, thereby preventing them from adhering to a surface (such as skin or hair) or causing contamination.
Natriquest E30 is commonly used in body washes, cleansers, and shampoos.
As a raw material, Natriquest E30 comes in either solid or granular form and is white in color.
Natriquest E30 is a water-soluble compound commonly used in the cosmetic industry as a chelating agent.

Natriquest E30 works by binding to metal ions, such as calcium and iron, thereby preventing them from causing undesirable reactions that may impact product texture and stability.
Natriquest E30 helps to keep cosmetic products looking and performing their best.
Natriquest E30 has a white or slightly yellow appearance in powder form, and its chemical formula is C10H16N2O8.
Natriquest E30's ability to sequester metal ions makes it an essential ingredient in many cosmetic formulations, especially those that contain surfactants or preservatives.

Natriquest E30 is a structural isomer of EDTA
Natriquest E30 is widely used in the personal care industry due to its ability to sequester metal ions and prevent them from causing negative effects on product stability and performance.
Natriquest E30 is used to improve the efficacy of products like cleansers and moisturizers.
By binding with metal ions that can interfere with the performance of active ingredients, Natriquest E30 can help improve the absorption and effectiveness of these products.

Natriquest E30 improves the performance and stability of these formulations.
Natriquest E30 helps to remove hard water minerals and other impurities that can cause hair damage, while also helping to enhance the effectiveness of conditioning agents.
Natriquest E30 is generally considered safe for skin and hair.

Natriquest E30 is a chelating agent.
Natriquest E30 helps maintain pH and removes heavy metal ions from the formulation by binding with them.
Natriquest E30 helps prevent the formula from oxidizing or otherwise spoiling.




APPLICATION:

-Hair cleansing
-Skin cleansing



BENEFITS:

-Prevents discoloration and malodor
-Reduces the effect of water hardness
-Readily biodegradable (non-EDTA)
-Ideal for wash-off applications



FEATURES:

-Anti-oxidants
-Peroxide stabilisation
-Biocide potentiator
-Reducing water hardness



FEATURES:

-It is an unique readily biodegradable chelating agent.
-It is effective as a preservative potentiator
-It is anti-oxidant in formulations.



PHYSICAL AND CHEMICAL PROPERTIES:

-Boiling Point: 516.7°C
-Melting Point: 220-222°C
-pH: 6.5-7.5
-Solubility: Highly soluble in water
-Viscosity: Low



CHEMICAL PROPERTIES:

-density: 1.63[at 20℃]
-vapor pressure: 1.9Pa at 25℃
-refractive index: n20/D 1.416
-solubility: 0.4 in mg/100g standard fat at 20 ℃
-pka: 7.5[at 20 ℃]
-Water Solubility: 1000g/L at 20℃
-LogP: -4.7 at 20℃



SPECIFICATIONS:

-Molecular Weight: 292.24 g/mol
-XLogP3-AA: -6.9
-Hydrogen Bond Donor Count: 6
-Hydrogen Bond Acceptor Count: 10
-Rotatable Bond Count: 11
-Exact Mass: 292.09066547 g/mol
-Monoisotopic Mass: 292.09066547 g/mol
-Topological Polar Surface Area: 173Ų
-Heavy Atom Count: 20
-Complexity: 348
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 2
-Undefined Atom Stereocenter Count: 0
-Defined Bond Stereocenter Count: 0
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 1
-Compound Is Canonicalized: Yes



STORAGE:

It can be stored at room temperature Protected from sunlight and heat




SYNONYM:

EDDS
Trisodium ethylenediamine disuccinate
(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))disuccinic acid
5WK2FGJ113
N,N'-Ethylenediamine disuccinic acid
Ethylenediaminedisuccinic acid, (S,S)-
(s,s)-ethylenediamine-n,n'-disuccinic acid
L-Aspartic acid, N,N'-1,2-ethanediylbis-
EDSS
(2~{S})-2-[2-[[(2~{S})-1,4-bis(oxidanyl)-1,4-bis(oxidanylidene)butan-2-yl]amino]ethylamino]butanedioic acid
ethylenediaminedisuccinic acid
L-Ethylenediaminedisuccinic acid
N,N'-Ethylenedi-L-aspartic acid
Aspartic acid, N,N'-ethylenedi-
EDDS cpd
Aspartic acid, N,N'-ethylenedi-, L,L-
ENVIOMET C265
EDDS [MI]
ENVIOMET C 265
ENVIOMET C-265
(S,S)-EDDS
UNII-5WK2FGJ113
EDDS S,S-FORM [MI]
SCHEMBL414800
CHEMBL5085406
DTXSID1051852
(s,s)-ethylenediaminedisuccinic acid
MFCD01664787
S,S'-ethylenediamine disuccinic acid
Aspartic acid, N,N'-ethylenedi-L,L-
AS-75462
(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))disuccinicacid
(2S)-2-[2-[[(1S)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid
(2S)-2-[2-[[(1S)-1-carboxy-3-hydroxy-3-oxo-propyl]amino]ethylamino]butanedioic acid
EKQ

Natural Shea butter is an all-natural green plant-derived solid oil.
Natural Shea butter and human sebum-secreted oil indicators are close, contain rich non-saponifiable components, easy to absorb by the human body, can prevent drying and cracking, and further restore and maintain the natural elasticity of the skin.
Natural Shea butter also has an anti-inflammatory effect.

CAS: 194043-92-0

Synonyms:
Fats and Glyceridic oils, shea butter;BUTYROSPERMUM PARKII (SHEA BUTTER LIQUID);SHEA BUTTER BUTYROSPERMUM PARKII;Shea Butter Organic Certified;Shea Butter Powder;Shea Butter SB-I;Shea Liquid;Shea Liquid - Lo Freeze

Natural Shea butter is used for cosmetics, medicine research and development, and other scientific purposes.
Natural Shea butter, a fat extracted from the African Shea tree nut, is a triglyceride derived from oleic acid and stearic acid.
The U.S. Food and Drug Administration (FDA), also considers shea butter to be edible: Generally Recognized as Safe (GRAS3) and shea can be used in confectionery coatings or fillings, in the US.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes.
Extractives and their physically modified derivatives.
Natural Shea butter consists primarily of the glycerides of the fatty acids linoleic, oleic, stearic and palmitic.
(Butyrospermum parkii)
Natural Shea butter is a beige white to creamish white solid with a slight odor.
Natural Shea butter is a natural premium choice for your cosmetic formulations.
Natural Shea butter present interesting natural alternatives for cosmetic formulations.
They deeply hydrate and nourish the skin.
Butters have same properties than oils, but will bring additional texture and consistency to a formula.

Natural Shea butter or karite butter is unrefined and is produced in the north of Ghana, West Africa by a social enterprise group of local people who gather the nuts which grow wild on the Karite tree.
Natural Shea butter is then processed and the result is the most fantastic ‘natural’ shea butter.
Shea butter is extremely moisturising, and is very useful for very dry skin.
Natural Shea butter melts at skin temperature, which makes it so versatile and so useable in most body creams, balms, massage bars and soaps.
Natural Shea butter is almost completely unsaponifiable which makes it a fabulous addition to cold process soap.
The addition of around 10% makes a stable, conditioning, silky bar of soap, although Natural Shea butter does appear to accelerate trace considerably.

Natural Shea butter is obtained from the fruit (nuts) of shea tree, a tree mainly present on the African continent.
Natural Shea butter is composed mainly of triglycerides, fatty acids, esters of wax and active ingredients: among them, vitamins (A, D, E), resinous esters, phytosterols, latex.
Natural Shea butter is used in many cosmetics for its soothing and softening properties for the epidermis.
Natural Shea butter can also protect the skin and scalp from many external aggressions.
Natural Shea butter is a naturally nutritive product, and is usedfor the treatment of burns, skin patches, eczema, wrinkles, stretch marks and other minor skin conditions for centuries.
Natural Shea butter is rich in vitamin A and E and soft enough to hydrate the full body for babies and those with sensitive skin.
Natural Shea butter is a very moisturizing and protecting butter with mild antibacterial and anti-inflammatory characteristics.

Natural Shea butter is a white to off-white buttery material from the Butyrospermum Parkil, and has a characteristic-fatty odor.
Natural Shea butter is an organic product with a specific gravity of 0.91-0.98, an iodine value of 40-70, and a saponification value of 160-180.
Natural Shea butter is ideally used for skin care and O.T.C. pharmaceuticals.
Natural Shea butter is GMO-free, pesticide-free and no animal testing was used during processing.

Natural Tartaric Acid is an organic acid present in some fruits and widely used in the food and wine industry.
Natural Tartaric Acid (C4H6O6) is an organic acid which is present in a variety of plants and especially in grapes, often combined with potassium, calcium, and magnesium salt.


CAS number: 87-69-4
EC number: 201-766-0
MDL number: MFCD00064207
Chemical formula: HOOCCH(OH)CH(OH)COOH
Molecular Formula: C4H6O6


Natural Tartaric Acid is present in many fruits and the only use for industrial production is grapes.
Natural Tartaric Acid is a natural product that is derived from by-products of the grape.
Natural Tartaric Acid is a food grade product and it is Kosher certified.


Natural Tartaric Acid appears in nature in free state or more frequently in form of acid potassium salts and in a lesser proportion as calcium salts in the mulberries, cucumbers and to a high degree in grapes.
Natural Tartaric Acid is an organic acid present in some fruits and widely used in the food and wine industry.


Europe accounts for 86% of world production of Natural Tartaric Acid, producing around 30 000 tonnes per year.
Natural Tartaric Acid is an organic acid which is present in few fruits but in huge quantity only in grapes.
Natural Tartaric Acid appears as colourless crystals or white powder, almost odourless, of strong acid taste.


Natural Tartaric Acid is a white, crystalline organic acid that is naturally present in many fruits like grapes, bananas, tamarinds and citrus.
Natural Tartaric Acid is an of value component in wine making and as a flavoring and acidic agent for food.
The principal acid in grapes, Natural Tartaric Acid has a tart sour flavor.


Natural Tartaric Acid (C4H6O6) is an organic acid which is present in a variety of plants and especially in grapes, often combined with potassium, calcium, and magnesium salt.
Natural Tartaric Acid is present in many fruits and the only use for industrial production is grapes.


Natural Tartaric Acid is a natural product that is derived from by-products of the grape.
Natural Tartaric Acid is available as colourless monoclinic crystals or as odourless white powder with a pleasant acidic taste.
Natural Tartaric Acid is a clear, colourless liquid, free from matter in suspension.


Natural Tartaric Acid is dissolved in purified (reverse osmosis) potable water.
The aroma of Natural Tartaric Acid: Neutral characters typically associated with a solution of Natural Tartaric Acid.
Natural Tartaric Acid is a product from nature that occurs in grape vines and its natural aspect is the fruit acid that gives grapes their flavour.


ATP manufactures Tartaric Acid in two forms:
Granules - Natural Tartaric Acid comes in the form of fine crystals, in 15kg, 500kg and 1 tonne bags.
Liquid - Natural Tartaric Acid is available as a 50%w/v solution (that is 500 grams per litre) in bulk tankers.


Natural Tartaric Acid is the principle acid in wine helping control acidity levels.
Natural Tartaric Acid is therefore a very important input into the winemaking process.
Natural Tartaric Acid is a white or almost white crystalline powder or colourless crystals, highly soluble in water, very soluble in alcohol.


Natural Tartaric Acid contains no less than 99.5 percent and no more than the equivalent of 101.0 percent of (2R,3R) -2,3-dihydroxybutanedioic acid, calculated with reference to the dry substance.
The solution of Natural Tartaric Acid is highly acidic.


Natural Tartaric Acid, a dicarboxylic acid, one of the most widely distributed of plant acids, with a number of food and industrial uses.
Natural Tartaric Acid is an organic acid, a natural product of grapes, obtained from the must, lees and pomace.
Natural Tartaric Acid is odourless with a crystalline, white appearance.


Natural Tartaric Acid present on the world market, the only form of acid naturally present in grapes and wine is L(+) tartaric acid.
Natural Tartaric Acid is a white crystalline diprotic aldaric acid.
Natural Tartaric Acid occurs naturally in many plants, particularly grapes, bananas, and tamarinds, is commonly combined with baking soda to function as a leavening agent in recipes, and is one of the main acids found in wine.


Salts of tartaric acid are known as tartrates.
Natural Tartaric Acid is a dihydroxyl derivative of succinic acid.
Natural Tartaric Acid is a white, crystalline organic acid that occurs naturally in many fruits, most notably in grapes, but also in bananas, tamarinds, and citrus.


Natural Tartaric Acid's salt, potassium bitartrate, commonly known as cream of tartar, develops naturally in the process of fermentation.
Natural Tartaric Acid is commonly mixed with sodium bicarbonate and is sold as baking powder used as a leavening agent in food preparation.
Natural Tartaric Acid itself is added to foods as an antioxidant E334 and to impart its distinctive sour taste.


Natural Tartaric Acid may be most immediately recognizable to wine drinkers as the source of "wine diamonds", the small potassium bitartrate crystals that sometimes form spontaneously on the cork or bottom of the bottle.
These "tartrates" are harmless, despite sometimes being mistaken for broken glass, and are prevented in many wines through cold stabilization.


The tartrates remaining on the inside of aging barrels were at one time a major industrial source of potassium bitartrate.
Natural Tartaric Acid is a white crystalline diprotic acid.
Natural Tartaric Acid occurs naturally in many plants including grapes, bananas and tamarinds.


Natural Tartaric Acid is commonly combined with baking soda to function as a leavening agent in cooking recipes, and is one of the main acids found in wine.
Natural Tartaric Acid is the most widely adjusted acid in wine making.
Natural Tartaric Acid is a white crystalline diprotic organic acid.


Natural Tartaric Acid occurs naturally in many plants, particularly in grapes, bananas, and tamarinds.
Natural Tartaric Acid is also one of the main acids found in wine. Natural Tartaric Acid can be added to food when a sour taste is desired.
Natural Tartaric Acid is an organic acid that occurs in many plants.


Grapes do have a high proportion of Natural Tartaric Acid.
Natural Tartaric Acid belongs to the alpha hydroxy acid (AHA) family, alongside ascorbic, citric, glycolic, lactic and malic acids.
Natural Tartaric Acid has a salt, potassium bitartrate, commonly known as cream of tartar.


Natural Tartaric Acid is approved as food additive E 334.
Natural Tartaric Acid is odorless and colorless crystals that have a very sour taste.
Natural Tartaric Acid occurs naturally in many fruits.


Natural Tartaric Acid is especially abundant in grapes and citrus fruits.
In some products, Natural Tartaric Acid is combined with magnesium, calcium or potassium.
Natural Tartaric Acid is produced in the form of colorless hygroscopic crystals or white powder, odorless, very sour in taste.


Easily soluble in ethyl alcohol and water, Natural Tartaric Acid does not dissolve in ether, benzene, aliphatic hydrocarbons.
Natural Tartaric Acid is a dibasic salt of potassium acid, it can be in the form of a racemate or stereoisomers of three types: L-, D-, mesotartaric acid.
The density of Natural Tartaric Acid is 1.76 g/ cm³ , melting occurs at a temperature of 170°C.


Natural Tartaric Acid, whose formula is C 4 H 6 O 6 , is a fairly common compound in nature.
Natural Tartaric Acid is abundant in acidic fruit juices, such as grapes.
For the production of Natural Tartaric Acid sold in Ukraine, materials obtained as waste in the manufacture of wine are used: tartaric lime, tartar.


Also, for this purpose, Natural Tartaric Acid is possible to use dry wine yeast, sometimes, quite rarely, fresh fruit.
The chemical formula of Natural Tartaric Acid is C 4 H 6 O 6 .



USES and APPLICATIONS of NATURAL TARTARIC ACID:
Gypsum industry: Natural Tartaric Acid is used for retarding the gypsum hardening
Wine-making industry: Natural Tartaric Acid is used for correcting the acidity in the winemaking process.
Chemical industry: Natural Tartaric Acid is used for preparing tartars and as a chelating agent.


Natural Tartaric Acid is used in many different applications due to its properties as: antioxidant, acidifier, flavor enhancer, stabilizer and sequestering agent.
Natural Tartaric Acid is an organic acid present in some fruits and widely used in the food and wine industry.


Natural Tartaric Acid is also used as an additive in certain foods such as baby milk, sweets, jams and fruit juices.
Oenology: Natural Tartaric Acid is used to correct the acidity of the wine.
Pharmaceutical industry: Natural Tartaric Acid is used as an excipient in the preparation of some medicines.


Building industry: Natural Tartaric Acid is used in the gypsum and cement industries to retard drying and in the ceramic industry as fluidizer.
Cosmetic industry: Natural Tartaric Acid is used as a basic component in some natural body creams.
Galvanoplastic industry: Natural Tartaric Acid is used in preparation of polishing and cleaning solutions for electronic and galvanoplastic industry.


Natural Tartaric Acid is used textilessed as dyeing and printing agent.
Natural Tartaric Acid is a product extremly versatile as it is used in a wide range of industries.
Wine – Making Industry uses of Natural Tartaric Acid: Natural Tartaric Acid used to restore or correct wine acidity.


Pharmaceuticals Industry: Natural Tartaric Acid is used in the preparation of specific medicines (antibiotics, cardio tonics etc.) and as excipient (it is not metabolized by the human body).
Cosmetic Industry: Natural Tartaric Acid is used as a base compound in many natural body creams.


Natural Tartaric Acid's distinctive sourness enhances flavor when used at low levels in a range of applications such as soups, jams & jellies, frozen desserts and more.
Natural Tartaric Acid can also be used to control the pH level of liquids and solids so it has practical applications in beverage production, winemaking and other industries.


Its ability to bind with itself makes Natural Tartaric Acid a suitable raw material for many manufacturing processes which depend on molecular stability.
At high temperatures Natural Tartaric Acid melts slowly without decomposing so this feature allows for safe processing without any destruction from heat.
Natural Tartaric Acid is definitely a valuable resource that should be taken advantage of because of its wide range of uses and practicality.


Natural Tartaric Acid most commonly used when increasing acidity in grape must.
Natural Tartaric Acid is used in many different applications due to its properties as: antioxidant, acidifier, flavor enhancer, stabilizer and sequestering agent.


Natural Tartaric Acid is used in many different applications due to its properties as an antioxidant, acidifier, flavour enhancer, stabilizer and sequestering agent.
The pharmaceutical Industry: Natural Tartaric Acid has a number of uses in the pharmaceutical industry including use as an excipient in the preparation of some medicines.


The building Industry: Natural Tartaric Acid is also used in the gypsum and cement industries to retard drying and also in the ceramics industry as a fluidized.
The cosmetic industry: Natural Tartaric Acid is used extensively as a basic component in some natural body creams.


Using Natural Tartaric Acid – Liquid creates wines that are accepted worldwide and holistically faithful to the winemaking process.
Natural Tartaric Acid – Liquid prevents spoilage and keeps wine sound, balances the wine structure and interacts with the fruit and tannin profile.
Natural Tartaric Acid is fundamental to making exceptional wines, and appreciated by those who pride themselves in creating exceptional wine.


Natural Tartaric Acid is made using vinous raw materials to be used as a food additive.
Wine making: Natural Tartaric Acid is used in wine making for the acidification of the wines, musts and derivatives.
In pharmacy: Natural Tartaric Acid is used as an excipient to prepare antibiotics, effervescent tablets and pills, granulates and powders.


Natural Tartaric Acid is found in the branches, leaves and grapes of vines and is extracted from tartrate, which is created in wine production.
For processing as additives in foodstuffs, the rule is that only the Natural Tartaric Acid and its salts may be used.
Natural Tartaric Acid is used in the processing industry as a food additive in bakery products and confectionery, in drinks and dairy products and in a number of technical applications.


Natural Tartaric Acid supports the effect of antioxidants and in the foodstuffs sector it regulates the speed of gelling of aspics and desserts.
Additional applications of Natural Tartaric Acid are to be found with Acitum Tartaricum (Latin name), in, among other things, the colouring of metals, the silver plating of glass and electroplating technology.


Natural Tartaric Acid is especially suitable for the processing and production of end products in the foodstuffs industry and for technical applications.
Natural Tartaric Acid is added to other foods to give a sour taste, and is used as an antioxidant.
Natural Tartaric Acid plays an important role chemically, lowering the pH of fermenting "must" to a level where many undesirable spoilage bacteria cannot live, and acting as a preservative after fermentation.


In the mouth, Natural Tartaric Acid provides some of the tartness in the wine, although citric and malic acids also play a role.
Natural Tartaric Acid and its derivatives have a plethora of uses in the field of pharmaceuticals.
For example, Natural Tartaric Acid has been used in the production of effervescent salts, in combination with citric acid, to improve the taste of oral medications.


The potassium antimonyl derivative of the acid known as tartar emetic is included, in small doses, in cough syrup as an expectorant.
Natural Tartaric Acid also has several applications for industrial use.
Natural Tartaric Acid has been observed to chelate metal ions such as calcium and magnesium.


Therefore, Natural Tartaric Acid has served in the farming and metal industries as a chelating agent for complexing micronutrients in soil fertilizer and for cleaning metal surfaces consisting of aluminium, copper, iron, and alloys of these metals, respectively.
Natural Tartaric Acid is also used as an antioxidant.


In wine making, add Natural Tartaric Acid as in recipe or add to taste.
In cooking Natural Tartaric Acid helps prevent crystallization in sugar, creating softer, more elastic sugar for pulling and blowing.
Dissolve Natural Tartaric Acid in warm water (85F to 90F) at a ratio of 1- 1 pour tartaric solution into Amber bottle and use as needed.


Natural Tartaric Acid is added to other foods to give a sour taste, and is used as an antioxidant.
Natural Tartaric Acid is also used for making Mascarpone, an Italian soft cheese which is made from cream and has a rich velvety texture with a sweet delicate flavor.


Mascarpone is used as a cream with fruit and cakes as well as in many dessert recipes.
Because of that Natural Tartaric Acid is industrially produced in the production of wine as a by-product.
Today, Natural Tartaric Acid is used equally in the food industry and technical areas.


Natural Tartaric Acid, which is also declared as E 334 in the food sector, is particularly common in soft drinks, wine gums, ice-cream and for example for the stabilization of creams, because of its preservative properties and fruity taste.
In addition, Natural Tartaric Acid is also approved for used in organic foods.


Natural Tartaric Acid is used in the food sector and in technical applications.
In skincare Natural Tartaric Acid is used as a gentle exfoliating acid, and can be utilised in exfoliants, toners, serums and other personal care products.
Technically, Natural Tartaric Acid is used in large quantities, for example in the production of cement in order to extend the processing time here or in the metal industry for surface treatment.


Natural Tartaric Acid is used soft drinks, wine gums and ice cream, as well as for example to stabilize creams.
In the technical field, Natural Tartaric Acid is used in the cement and metalworking industries.
Natural Tartaric Acid is found naturally in fruits, various plants, as well as in wine, and is a by-product of the wine industry.


Natural Tartaric Acid is a versatile ingredient, used extensively in the food industry as an acidulant and additive.
Natural Tartaric Acid gives a sharp, tangy taste and can be added to jellies, beverages, gelatin and other foods.
Due to its natural origin, Natural Tartaric Acid is generally used in the food sector.


Examples include applications of Natural Tartaric Acid as a complexing agent or acidity regulator.
In addition, Natural Tartaric Acid is used in the technical sector for the production or dyeing of textiles or added as a retarder in cement processing.
Natural Tartaric Acid is used for industrial purposes.


-The wine industry uses of Natural Tartaric Acid:
Natural Tartaric Acid is the most important acidity regulator in wine and is vitally important to the Australian winemaking industry.
Natural Tartaric Acid’s main use is in the wine industry as it is unique in that it is not found in most fruit, but it is the primary acid component in grapes.
Natural Tartaric Acid is the principle acid in wine and controls the acidity levels of the wine and is a very important input into the winemaking process.


-The food Industry uses of Natural Tartaric Acid:
Natural Tartaric Acid is an acidifier that enhances the flavor of ingredients used in the production of sweets, candies, fruit jellies, jams, fruit juices and ice-creams.
Natural Tartaric Acid is used as an emulsifier and preservative in bread making and is also an essential ingredient as effervescence for table waters and as a leavening agent for desserts.


-Pharmaceutical and cosmetic industries uses of Natural Tartaric Acid:
Natural Tartaric Acid is very useful the tartaric acid optical activity and its capacity of forming complexes.
The mixture of Natural Tartaric Acid and sodium salts it is the base for the effervescent formulations to prepare antacids, fruit salts and artificial sweeteners.


-In food:
Identified in the Codex Alimentarius as E334, Natural Tartaric Acid is an acidifier and natural preservative, as a flavour enhancer in desserts, sweets, jams, jellies, ice-creams and fruit juice.
Natural Tartaric Acid is also used as an ingredient in raising agents and as an emulsifier in the baking industry.


-The food industry uses of Natural Tartaric Acid:
Natural Tartaric Acid stabilizing power, inhibiting microbial activity, endows it with excellent properties as a food preservative for meat and fish.
Natural Tartaric Acid is used in the manufacturing of sweets and gelatines.

Natural Tartaric Acid is used as a yeast in bakery.
Natural Tartaric Acid is used to prepare efferverscent drinks.
Natural Tartaric Acid is used in the cheese making process.

Natural Tartaric Acid is used in fat industries.
Natural Tartaric Acid is used as an acidulant in refreshing soft drinks.


-Food industry uses of Natural Tartaric Acid:
This is the main use of natural Tartaric Acid:
*As acidulant and natural preservative for jams and softdrinks.
*As emulsifier and preservative for bread-making.
*As effervescence for table waters.
*As leavening agent for desserts.


-Other industriesuses of Natural Tartaric Acid:
Natural Tartaric Acid is used as a color polishing, fiber smoothing, textile printing and dye manufacturing.
Natural Tartaric Acid is used to regulate pH in the photographic industry.
Natural Tartaric Acid is used in galvanotechnics.


-Food Industry uses of Natural Tartaric Acid:
This is the sector where Natural Tartaric Acid is most used as acidifier and natural preservative for jams, fruit juices, preserves, soft drinks etc.; it is also used in emulsifiers for bread making, in table waters as effervescent and in desserts as leavening.


-Construction Industry uses of Natural Tartaric Acid:
Natural Tartaric Acid is used in the gypsum and cement industries as setting retarder and in the ceramic industry as fluidifier.
Natural Tartaric Acid produced by Distillerie Mazzari is “Kosher” and “Halal” certified as it satisfy the food standards respectively of the Orthodox Jewish and Islamic Religions.



FOOD INDUSTRY USES OF NATURAL TARTARIC ACID:
– Natural Tartaric Acid is used as acidifier and natural preservative for marmalades, ice cream, jellies, juices, preserves, and beverages.
– Natural Tartaric Acid is used as effervescent for carbonated water.
– Natural Tartaric Acid is used as emulsifier and preservative in the bread-making industry and in the preparation of candies and sweets.



OENOLOGY USES OF NATURAL TARTARIC ACID:
Natural Tartaric Acid is used as an acidified.
Natural Tartaric Acid is used in musts and wines to prepare wines that are more balanced from the point of view of taste, the result being an increase in their degree of acidity and a decrease in their pH content.


PHARMACEUTICALS INDUSTRY USES OF NATURAL TARTARIC ACID::
Natural Tartaric Acid is used as an excipient for the preparation of effervescent tablets.


CONSTRUCTION INDUSTRY USES OF NATURAL TARTARIC ACID:
Natural Tartaric Acid is used in cement, plaster, and plaster of Paris to retard drying and facilitate the handling of these materials.


COSMETICS INDUSTRY USES OF NATURAL TARTARIC ACID:
Natural Tartaric Acid is used as a basic component of many natural body crèmes.



CHEMICAL SECTOR OF NATURAL TARTARIC ACID:
– Galvanic baths
– Electronics industry
– As mordant in the textile industry
– As an anti-oxidant in industrial greases



WHERE IS NATURAL TARTARIC ACID APPLIED?
*In the food industry as a preservative and flavoring agent;
*In the cosmetic industry, where E334 is a component of many creams and lotions for the body and face;
*In the pharmaceutical industry, where it is widely used in the production of various soluble medicines, as well as effervescent tablets and some other drugs;
*In analytical chemistry - for the detection of aldehydes and sugars, as well as for the separation of racemates of organic substances into isomers;
*In construction - to slow down the drying of some building materials, such as cement and gypsum;
*In the textile industry - for dyeing fabrics.



NATURAL TARTARIC ACID IS USED IN THE FOLLOWING INDUSTRIES:
*Wine industry for acidification of grape musts.
*Pharmaceutical industry as an excipient or carrier for the active ingredient.
*Bakery industry as an emulsifier and preservative.
*Cement, plaster and gypsum industries for the retardant action.
*Food industry as an acidifier and taste enhancer in sweets, jellies, jams, fruit nectar and ice creams.
*Natural Tartaric Acid can be used in grease and oils as an antioxidant and for polishing and cleaning of metals.



CHARACTERISTICS AND PROPERTIES OF NATURAL TARTARIC ACID:
Natural Tartaric Acid is an organic acid, a natural product of grapes, obtained from the must, lees and pomace.
Natural Tartaric Acid is odourless with a crystalline, white appearance.
Of the various forms of Natural Tartaric Acid present on the world market, the only form of acid naturally present in grapes and wine is L(+) tartaric acid.

Natural Tartaric Acid is a natural product that is highly versatile and has a multitude of uses in industry thanks to its numerous qualities: as an acidifier, antioxidant, stabiliser and pH corrector to name just a few.
Widely utilised in the food and cosmetics sector, Natural Tartaric Acid also has multiple uses in various fields.



RAW MATERIALS OF NATURAL TARTARIC ACID:
The tartaric raw materials used in the manufacturing process of Natural Tartaric Acid come from the grape, as being the natural source of major content in salts derived from tartaric acid.

Tradicionally the raw materials in the natural tartaric acid manufacturing process are:
*Calcium Tartrate
*Potassium Bitartrate
*Cream of Tartar.
*Calcium Tartrate

The calcium tartrate is obtained as a by-product from the wine distilleries, once the potassium bitartrate has been transformed.
It arrives at the factory as small crystals, usually yellow or purple in color that is stored in silos.
Its tartaric purity ranges between 45 - 52 %.



MANUFACTURING PROCESS OF NATURAL TARTARIC ACID:
The raw materials are stored in the silos.
The Natural Tartaric Acid manufacturing process consists in the transformation of the raw materials (natural tartaric salts) in acid medium.
Once the reaction has finished, the impure tartaric solutions filtered are concentrated to obtain a red crystalline mass.

The red crystals obtained are dissolved in water and purified.
Once purified, the tartaric solutions are concentrated to obtain a white crystalline mass.
The moist white crystals obtained are dried.

After drying, the tartaric acid crystals are sieved to select different crystal sizes.
The natural product finished, once all the strict quality control tests have been passed, is stored in a fresh and dry place waiting for its subsequent transportation.



PHYSICAL and CHEMICAL PROPERTIES of NATURAL TARTARIC ACID:
Appearance: Cristals or cristalline powder
Colour: White or transparent
Odour: Odourless
Relative Density: 1,76g/ml
Melting Point: 169 °C at 1013 hPa (mbar)
Specific Rotation: (C = 20% in water): +(12º - 12,8º)
Descomposition at: t > 220º C
Solubility in water: 1,390 g/L at 20 °C
Formula: C4H6O6
Chemical formula: HOOCCH(OH)CH(OH)COOH
Molecular mass: 150.09

Appearance: white or almost white, crystalline powder or colourless crystals,
Melt Point °C: 168 - 170°C
Colour: White, off-white
Boiling Range: 179.1°C @ 1013 hPa
Water solubility: very soluble in water
CAS: 87-69-4
Commercial Name: L(+) Tartaric Acid of natural origin (vegetable)
IUPAC name: (2R,3R)-2,3-Dihydroxybutanedioic acid
Formula: C4H6O6
Solubility: 1390g/L (20° C)
Molecular weight: 150.09
Melting Point: 168-170 C°
PH (1.5g/l in water): 2,2

Appearance: CLEAR COLOURLESS LIQUID Solubility (water) MISCIBLE
Odour: ODOURLESS Specific Gravity 1.21
pH: ACIDIC % Volatiles NOT AVAILABLE
Vapour Pressure: NOT AVAILABLE Flammability NOT APPLICABLE
Vapour Density: NOT AVAILABLE Flash Point NOT APPLICABLE
Boiling Point: NOT AVAILABLE Upper Explosion Limit NOT AVAILABLE
Melting Point: NOT AVAILABLE Lower Explosion Limit NOT AVAILABLE
Evaporation Rate: NOT AVAILABLE
Auto ignition Temperature: NOT AVAILABLE
application(s): flavors and fragrances
assay: ≥99.7%

autoignition temp.: 797 °F
biological source: Vitis vinifera
food allergen: no known allergens
grade: FG, Kosher, natural, Halal
InChI key: FEWJPZIEWOKRBE-JCYAYHJZSA-N
InChI: 1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m1/s1
mp: 170-172 °C (lit.)
organoleptic: odorless
SMILES string: O[C@H]([C@@H](O)C(O)=O)C(O)=O
vapor density: 5.18 (vs air)



FIRST AID MEASURES of NATURAL TARTARIC ACID:
-Description of first-aid measures:
General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of NATURAL TARTARIC ACID:
-Personal precautions, protective equipment and emergency procedures:
Ensure adequate ventilation.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Take up dry.
Clean up affected area.



FIRE FIGHTING MEASURES of NATURAL TARTARIC ACID:
-Extinguishing media:
Suitable extinguishing media:
Water Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NATURAL TARTARIC ACID:
-Control parameters:
Ingredients with workplace control parameters:
-Exposure controls:
Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles.
*Skin protection:
Protective clothing.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Protective clothing.
*Hand protection:
Protective gloves.
*Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NATURAL TARTARIC ACID:
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.
Dry.
-Precautions for safe handling:
*Technical measures:
Handling is performed in a well ventilated place.
Wear suitable protectiveequipment.
Wash hands and face thoroughlyafterhandling.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed.
Store in a cool and dark place.



STABILITY and REACTIVITY of NATURAL TARTARIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Incompatible materials:
No data available



SYNONYMS:
L(+) Tartaric Acid
(2R,3R)-2,3-dihydroxybutanedioic acid
Butanedioic acid, 2,3-dihydroxy-
(2R,3R)-2,3-Dihydroxybutanedioic acid
L-(+) tartaric acid
L-2,3-dihydroxybutanedioic acid
d-α,β-dihydroxysuccinic acid

n-butyl alcohol; 1-Butyl alcohol; Butanolen; Butanol; Butan-1-ol; 1-Butan-1-ol; Butyl hydroxide; 1-Hydroxybutane; Methylolpropane; Propylcarbinol; Propylmethanol; Butylowy alkohol; Butyric alcohol; Propylmethanol; Nomal Butanol; cas no: 71-36-3

N-Butanol is a primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group.
N-Butanol is a colourless liquid of medium volatility and a characteristic banana-like odour.
N-Butanol is a primary alcohol, a short-chain primary fatty alcohol and an alkyl alcohol.

CAS Number: 71-36-3
Molecular Formula: C4H10O
Molecular Weight: 74.12
EINECS Number: 200-751-6

N-Butanol produced in small amounts in humans by the gut microbes.
N-Butanol has a role as a protic solvent, a human metabolite and a mouse metabolite.
N-Butanol is a clear, mobile solvent with a characteristic odour similar to banana.

N-Butanol is flammable and has medium volatility.
N-Butanol is miscible with common solvents such as alcohols, ketones, aldehydes, ethers, glycols and aromatic and aliphatic hydrocarbons but has only limited miscibility in water.
N-Butanol is a primary alcohol with a molecular formula of C4H10O.

N-Butanol has limited miscibility in water; however, it is easily soluble in regular solvents such as ethers, alcohol, glycols and hydrocarbons.
This solvent is very flammable, with a flashpoint of around 35° C.

N-Butanol is a colourless liquid that has a very characteristic strong odour.
N-Butanol manufacturing process is quite complex, especially when it comes to health risks.
N-Butanol’s also known as Butyl Alcohol.

N-Butanol is found in its natural state, a product of fermentations of some foods and fruits that contain sugars.
N-butanol, also known as normal butanol or n-butyl alcohol, is a type of alcohol with the chemical formula C4H9OH.
N-Butanol is one of the four isomers of butanol, with the other three being isobutanol, sec-butanol, and tert-butanol.

The "n" in n-butanol stands for "normal," indicating that its carbon chain is linear.
N-butanol is a colorless liquid with a strong alcoholic odor.
N-Butanol is soluble in water and commonly used as a solvent in various industrial applications, including paints, coatings, and chemical processes.

N-Butanol can also be found in some consumer products such as cleaning agents, perfumes, and personal care products.
Additionally, N-Butanol is used as a fuel additive and in the production of plastics, resins, and pharmaceuticals.

N-Butanol is a type of alcohol with four carbon atoms being contained per molecule.
N-Butanol molecular formula is CH3CH2CH2CH2OH with three isomers, namely iso-butanol, sec-butanol and tert-butanol.
N-Butanol is colorless liquid with alcohol odor.

N-Butanol has the boiling point of being 117.7 ℃, the density (20 ℃) being ​​0.8109g/cm3, the freezing point being-89.0 ℃, flash point being 36~38 ℃, self-ignition point being 689F and the refractive index being (n20D) 1.3993.
At 20 ℃, its solubility in water is 7.7% (by weight) while the water solubility in N-Butanol was 20.1% (by weight).
N-Butanol is miscible with ethanol, ether and other kinds of organic solvents.

N-Butanol can be used as the solvents of a variety of paints and the raw material for producing the plasticizers, dibutyl phthalate.
N-Butanol can also be used for the manufacture of butyl acrylate, butyl acetate, and ethylene glycol butyl ether and also used as the extract of intermediates of organic synthesis and biochemical drugs and can also used in the manufacture of surfactants.
N-Butanol steam can form explosive mixtures with air with the explosion limit being 3.7%~10.2% (volume fraction).

N-Butanol was first discovered by C-A. Wurtz (French) from the fusel oil obtained from the fermentation process of alcohol in 1852.
In 1913, the British Strange-Graham Companies have used corn as raw material for production of acetone through the fermentation process with butanol being the main byproduct.
Later, due to the increasing demand for butanol, the fermentation production factory began to mainly synthesize n-butanol with acetone and ethanol being the major byproduct.

During the Second World War, the German chemical company (Ruhr) began to apply propylene carboxyl method for the production of N-Butanol.
With the rise of the oil industry in 1950s, the N-Butanol synthesis method had gotten rapid development with the propylene carboxyl method having the fastest speed.
N-butanol is classed as a flammable liquid with a flammability rating of 3 under the NDPA 704 due to its flashpoint of 35 °C.

A bulk solvent exporter, such as Solventis, would normally distribute this solvent in bulk vessels or tank trucks.
N-butanol can occur naturally as a product of the fermentation of sugars and other carbohydrates.
However, the major use (and therefore production) is in the industrial arena.

N-Butanol is a bulk petrochemical manufactured from the feedstock of propylene in an ‘oxo process’ in the presence of a homogeneous catalyst.
This creates butyraldehyde which is subsequently hydrogenated to produce n-butanol.

N-Butanol has the same use as the rest of its chemical group.
Alcohols work as an intermediary for chemical reactions in industry, being used as a solvent and dehydrating agent.

N-butanol is a four-carbon alcohol with a linear carbon chain, which means it has a straight-chain structure.
N-butanol is a colorless liquid at room temperature with a boiling point of about 117.7 degrees Celsius (243.9 degrees Fahrenheit).

N-Butanol has a slightly sweet odor, similar to that of other alcohols.
N-butanol is soluble in water to some extent, which makes it useful as a solvent.
However, it is less soluble in water compared to its isomers like ethanol or methanol.

N-Butanol is a clear, mobile, neutral liquid with a characteristic odour.
N-Butanol is miscible with all common solvents, e. g. alcohols, ketones, aldehydes, ethers, glycols, and aromatic and aliphatic hydrocarbons.
N-Butanol miscibility with water, however, is restricted. n-Butanol is used as a solvent and as a feedstock for syntheses.

A survey of the various applications is presented below, but does not claim to be complete.
About half of the production of pure n-Butanol and its derivates (primarily esters) is used as solvents in the coatings industry.
The advantage here is that n-butanol prevents blushing of certain coatings when they dry under humid conditions.

Thus it is widely used as a diluent in cellulose nitrate lacquers and serves to improve their flow, gloss and resistance to blushing (blushing only occurs in the presence of volatile solvents and at high humidities).
For this purpose addition rates of 5-10 % are generally sufficient.
N-Butanol, also known as butan-1-ol or n-butanol, is a primary alcohol with the chemical formula C4H9OH and a linear structure.

Isomers of N-Butanol are isobutanol, butan-2-ol and tert-butanol.
The unmodified term butanol usually refers to the straight chain isomer.
N-Butanol occurs naturally as a minor product of the ethanol fermentation of sugars and other saccharides and is present in many foods and drinks.

N-Butanol is also a permitted artificial flavorant in the United States, used in butter, cream, fruit, rum, whiskey, ice cream and ices, candy, baked goods, and cordials.
N-Butanol is also used in a wide range of consumer products.

The largest use of N-Butanol is as an industrial intermediate, particularly for the manufacture of butyl acetate (itself an artificial flavorant and industrial solvent).
N-Butanol is a petrochemical derived from propylene.
Estimated production figures for 1997 are: United States 784,000 tonnes; Western Europe 575,000 tonnes; Japan 225,000 tonnes.

N-Butanol alcohol is a colourless flammable liquid with strong alcoholic odour.
N-Butanol alcohol is a highly refractive liquid and burns with a strongly luminous flame.
N-Butanol is incompatible with strong acids, strong oxidising agents, aluminium, acid chlorides, acid anhydrides, copper, and copper alloys.

N-Butanol alcohol has an extensive use in a large number of industries.
For instance, it is used as solvent in industries associated with the manufacturing of paints, varnishes, synthetic resins, gums, pharmaceuticals, vegetable oils, dyes, and alkaloids.
N-Butanol alcohol finds its use in the manufacture of artificial leather, rubber, plastic cements, shellac, raincoats, perfumes, and photographic films.

N-Butanol is a colorless flammable liquid with a strong alcoholic odor.
N-Butanol is a highly refractive liquid and burns with a strongly luminous flame.
N-Butanol is incompatible with strong acids, strong oxidizing agents, aluminium, acid chlorides, acid anhydrides, copper, and copper alloys.

N-Butanol has extensive use in a large number of industries.
For instance, N-Butanol is used as a solvent in industries associated with the manufacturing of paints, varnishes, synthetic resins, gums, pharmaceuticals, vegetable oils, dyes, and alkaloids.
N-Butanol is used in the manufacture of artificial leather, rubber, and plastic cements, shellac, raincoats, perfumes, and photographic films.

N-Butanol is a solvent, chemical intermediate and an additive in unleaded gasoline.
N-Butanol is a colorless, volatile liquid with a rancid sweet odor.
The air odor threshold of N-Butanol was reported to be 0.83 ppm ; others have identified the minimum concentration with identifiable odor as 11 and 15 ppm.

N-Butanol is clear, colorless liquid with a rancid sweet odor similar to fusel oil.
The least detectable odor threshold in concentration water at 60 °C was 0.2 mg/L.
Reported nasal pungency threshold concentrations ranging from approximately 900 to 4,000 ppm.

N-Butanol also known as N-Butanol is a primary alcohol with the chemical formula C4H9OH and a linear structure.
Isomers of n-Butanol are isobutanol, 2-butanol, and tert-butanol.
The unmodified term butanol usually refers to the straight chain isomer.

N-Butanol is a colourless flammable liquid with strong alcoholic odour.
N-Butanol is a highly refractive liquid and burns with a strongly luminous
flame.
N-Butanol is incompatible with strong acids, strong oxidising agents, aluminium, acid chlorides, acid anhydrides, copper, and copper alloys.

N-Butanol has an extensive use in a large number of industries. For instance, it is used as solvent in industries associated with the manufacturing of paints, varnishes, synthetic resins, gums, pharmaceuticals, vegetable oils, dyes, and alkaloids.
N-Butanol finds its use in the manufacture of artificial leather, rubber, plastic cements, shellac, raincoats, perfumes, and photographic films.

N-Butanol occurs naturally as a minor product of the fermentation of sugars and other carbohydrates and is present in many foods and beverages.
N-Butanol is also a permitted artificial flavorant in the United States, used in butter, cream, fruit, rum, whiskey, ice cream and ices, candy, baked
goods, and cordials.
N-Butanol is also used in a wide range of consumer products.

N-Butanol is a natural product found in Vitis rotundifolia, Cichorium endivia, peppermint oil from Brazil, Achillea ageratum, tea, apple aroma, American cranberry, black currants, guava fruit, papaya, cooked asparagus, tomato, Swiss cheese, Parmesan cheese, heated butter, cognac, Armagnac, rum and cider.
N-Butanol has been proposed as a substitute for diesel fuel and gasoline.
N-Butanol is produced in small quantities in nearly all fermentations (see fusel oil).

Clostridium produces much higher yields of N-Butanol.
N-Butanol is considered as a potential biofuel (butanol fuel).
N-Butanol at 85 percent strength can be used in cars designed for gasoline without any change to the engine (unlike 85% ethanol), and it provides more energy for a given volume than ethanol, almost as much as gasoline.

Therefore, a vehicle using N-Butanol would return fuel consumption more comparable to gasoline than ethanol.
N-Butanol can also be added to diesel fuel to reduce soot emissions.
The production of, or in some cases, the use of, the following substances may result in exposure to N-Butanol: artificial leather, butyl esters, rubber cement, dyes, fruit essences, lacquers, motion picture, and photographic films, raincoats, perfumes, pyroxylin plastics, rayon, safety glass, shellac varnish, and waterproofed cloth.

N-Butanol occurs naturally as a result of carbohydrate fermentation in a number of alcoholic beverages, including beer, grape brandies, wine, and whisky.
N-Butanol has been detected in the volatiles of hops, jack fruit, heat-treated milks, musk melon, cheese, southern pea seed, and cooked rice.
N-Butanol is also formed during deep frying of corn oil, cottonseed oil, trilinolein, and triolein.

N-Butanol is one of the "fusel alcohols" (from the German for "bad liquor"), which include alcohols that have more than two carbon atoms and have significant solubility in water.
N-Butanol is a natural component of many alcoholic beverages, albeit in low and variable concentrations.
N-Butanol (along with similar fusel alcohols) is reputed to be responsible for severe hangovers, although experiments in animal models show no evidence for this.

N-Butanol is used as an ingredient in processed and artificial flavorings, and for the extraction of lipid-free protein from egg yolk, natural flavouring materials and vegetable oils, the manufacture of hop extract for beermaking, and as a solvent in removing pigments from moist curd leaf protein concentrate.
N-Butanol is a primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group.

N-Butanol is produced in small amounts in humans by the gut microbes.
N-Butanol has a role as a protic solvent, a human metabolite and a mouse metabolite.
N-Butanol is a primary alcohol and an alkyl alcohol.

Melting point: -90 °C (lit.)
Boiling point: 116-118 °C (lit.)
Density: 0.81 g/mL at 25 °C (lit.)
vapor density: 2.55 (vs air)
vapor pressure: 6.7 hPa (20 °C)
FEMA: 2178 | BUTYL ALCOHOL
refractive index: n20/D 1.399(lit.)
Flash point: 95 °F
storage temp.: Store at +5°C to +30°C.
solubility: water: soluble
form: Liquid
pka: 15.24±0.10(Predicted)
color: APHA: ≤10
Relative polarity: 0.586
PH: 7 (70g/l, H2O, 20℃)
Odor: Alcohol-like; pungent; strong; characteristic; mildly alcoholic, non residual.
Odor Threshold: 0.038ppm
Odor Type: fermented
Evaporation Rate: 0.46
Relative density, gas (air=1): 0.81
explosive limit: 1.4-11.3%(V)
Water Solubility: 80 g/L (20 ºC)
Sensitive: Moisture Sensitive
λmax λ: 215 nm Amax: 1.00
λ: 220 nm Amax: 0.50
λ: 240 nm Amax: 0.10
λ: 260 nm Amax: 0.04
λ: 280-400 nm Amax: 0.01
Merck: 14,1540
JECFA Number: 85
BRN: 969148
Henry's Law Constant: 49.2 at 50 °C, 92.0 at 60 °C, 152 at 70 °C, 243 at 80 °C (headspace-GC, Hovorka et al., 2002)
Stability: Incompatible with strong acids, strong oxidizing agents, aluminium, acid chlorides, acid anhydrides, copper, copper alloys. Flammable.
LogP: 0.88

N-Butanol attacks plastics.
Mixtures with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions.
May form explosive butyl hypochlorite by reacting with hypochlorous acid.

N-Butanol are used as solvents for paints, lacquers, varnishes, natural and synthetic resins, gums, vegetable oils, dyes, camphor, and alkaloids.
They are also used as an intermediate in the manufacture of pharmaceuticals and chemicals; in the manufacture of artificial leather, safety glass; rubber and plastic cements, shellac, raincoats, photographic films, perfumes; and in plastic fabrication.

The acute toxicity of N-Butanol is relatively low, with oral LD50 values of 790–4,360 mg/kg (rat; comparable values for ethanol are 7,000–15,000 mg/kg).
N-Butanol is metabolized completely in vertebrates in a manner similar to ethanol: alcohol dehydrogenase converts N-Butanol to butyraldehyde; this is then converted to butyric acid by aldehyde dehydrogenase.
N-Butanol can be fully metabolized to carbon dioxide and water by the β-oxidation pathway.

In the rat, only 0.03% of an oral dose of 2,000 mg/kg was excreted in the urine.
At sub-lethal doses, N-Butanol acts as a depressant of the central nervous system, similar to ethanol: one study in rats indicated that the intoxicating potency of N-Butanol is about 6 times higher than that of ethanol, possibly because of its slower transformation by alcohol dehydrogenase.

N-Butanol may form explosive mixture with air.
In all cases they are Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Attacks some plastics, rubber and coatings.
N-Butanol is incompatible with strong acids; halogens, caustics, alkali metals; aliphatic amines; isocyanates.
N-Butanol forms an explosive peroxide in air.

Incompatible with strong oxidizers; strong acids; aliphatic amines; isocyanates, organic peroxides.
N-Butanol is incompatible with strong acids (including mineral acid), including mineral acids; strong oxidizers or caustics, aliphatic amines; isocyanates, alkali metals (i.e., lithium, sodium, potassium, rubidium, cesium, francium).
N-Butanol is incompatible with strong acids; strong oxidizers; caustics, aliphatic amines; isocyanates, alkali metals and alkali earth.

N-butanol can be produced through various methods, including the oxo process (also known as the hydroformylation of propene) and the hydroformylation of propionaldehyde.
As mentioned earlier, N-Butanol is one of four isomers of butanol.
The other isomers have different structures and properties.

N-Butanol, for instance, has a branched structure and is used in the production of chemicals like isobutyl acetate, while tert-butanol is used as a solvent and in the synthesis of pharmaceuticals.
N-butanol is sometimes used as an octane booster in gasoline.

By adding N-Butanol to gasoline, the octane rating of the fuel can be increased.
A higher octane rating can reduce engine knocking and improve overall engine performance.
N-butanol is used in the flavor and fragrance industry to enhance the aroma of certain products.

N-Butanol can be found in perfumes, colognes, and various scented products.
N-butanol is utilized in the pharmaceutical industry for various purposes.
N-Butanol can be used as a solvent in the synthesis of pharmaceutical compounds, and it may also be found as an excipient in some medications.

N-butanol can be found in cleaning products like household cleaners, degreasers, and industrial solvents due to its strong solvent properties, which help in breaking down and removing oils, greases, and other residues.
N-Butanol is used in the manufacture of plastics and resins, including acrylate resins and cellulose acetate butyrate, where it serves as a plasticizer or modifier to improve flexibility and other properties.

N-butanol can be produced through fermentation processes using certain microorganisms, making it a potential candidate for biofuel production.
N-Butanol has been considered as a biofuel alternative due to its energy density and compatibility with existing engines and infrastructure.
In the chemical and pharmaceutical industries, n-butanol is used for extraction and purification processes.

N-Butanol can be employed to separate and purify various compounds from mixtures.
While n-butanol itself is not typically used as a food additive, it can be present as a residue in trace amounts in some food products due to its use as a solvent or in food packaging materials.
Regulatory authorities set limits on the permissible levels of such residues to ensure food safety.

The production and use of n-butanol can have environmental impacts.
Efforts have been made to develop more environmentally friendly and sustainable methods for its production, such as bio-based processes.

Production method:
There are several methods for their preparation.
In the past, the production of N-Butanol has also used potatoes, grain or sugar as raw material and through their hydrolysis fermentation.

The resulting product from the fermentation broth contains a N-Butanol content of 54.8%~58.5%, acetone content of 30.9%~33.7%, and the ethanol content of 7.8%-14.2%. With the development of petrochemical industry, fermentation method has been gradually phased out.
The reaction equation is as follows: (C6H10O5) n [n (H2O)] → [strain] n-C6H12O6 [fermentation] → CH3COCH3 + C4H9OH + C2H5OH

The resulted fermentation broth was further fractionated to obtain acetone, ethanol and N-Butanol separately.
Take acetaldehyde as raw material, add dilute alkali solution to give 2-hydroxybutyraldehyde at temperature below 20 ℃ with the reaction being stopped upon reaching 50%.
N-Butanol use alkali to neutralize the acid and recycle the unreacted acetaldehyde and extract the 2-hydroxybutyraldehyde.

Then use acidic catalyst such as sulfuric acid and acetic acid for dehydration to obtain crotonaldehyde at 105~137 ℃, then use copper complex catalyst for hydrogenation at 160~240 ℃ to obtain the crude butyraldehyde and N-Butanol with distillation to obtain the products.
CH3CH = CHCHO + H2 [catalyst] CH3CH2CH2CHO + CH3CH2CH2CH2OH

N-Butanols synthesis method including the following several ways: Fermentation and Propylene carbonyl synthesis.
Put propylene, carbon monoxide and hydrogen to the catalytic bed for reaction with catalyst being zeolite for absorbing cobalt salt or fatty acid cobalt with the reaction temperature being 130~160 ℃ and the reaction pressure being 20~25MPa.

The reaction can generate n-butyraldehyde and iso-butyraldehyde with separation via distillation and further catalytic hydrogenation of the n-butyraldehyde to obtain the N-Butanol.
CH3CH2CH2CHO + H2 → CH3CH2CH2CH2OH

N-Butanol applies the mixture of iron pentacarbonyl, n-butyl pyrrolidine and water.
However, the one-way conversion of the propylene is low with only 8% to 10%.
Reaction equation: CH3CH = CH2 + 3CO + 2H2O → n-C4H9OH + 2CO2

Uses
N-Butanol is the most important in industries and the most extensively studied.
N-Butanol is a colorless liquid with a strong, mildly alcoholic odor.
N-Butanol is used in chemical derivatives and as a solvent for paints, waxes, brake fluid, and cleaners.

N-Butanol is the allowable food flavors documented in the "food additives health standards" of China.
N-Butanol is mainly used for the preparation of food flavors of bananas, butter, cheese and whiskey.
For the candy, the usage amount should be 34mg/kg; for baked foods, it should be 32mg/kg; for soft drinks, it should be 12mg/kg; for cold drinks, it should be 7.0mg/kg; for the cream, it should be 4.0mg/kg; for alcohol, it should be 1.0mg/kg.

N-Butanol is mainly used for the manufacture of the n-butyl plasticizers of phthalic acid, aliphatic dicarboxylic acid and phosphoric acid that are widely applied to various kinds of plastic and rubber products.
N-Butanol can also be used as the raw material of producing butyraldehyde, butyric acid, butyl-amine and butyl lactate in the field of organic synthesis.
N-Butanol can also be used as the extraction agent of oil, drugs (such as antibiotics, hormones and vitamins) and spices as well as the alkyd paint additives.

N-Butanol can be used as the solvent of organic dyes and printing ink and de-waxing agent.
N-Butanol is used in the production of butylacetate, butyl glycol ether, and plasticizerssuch as dibutyl phthalate; as a solvent in thecoating industry; as a solvent for extractionsof oils, drugs, and cosmetic nail products;and as an ingredient for perfumes and flavor.

N-Butanol occurs in fusel oil and as aby-product of the fermentation of alcoholicbeverages such as beer or wine. It is presentin beef fat, chicken broth, and nonfilteredcigarette smoke
N-Butanol is used in the following products: lubricants and greases, coating products, anti-freeze products, adhesives and sealants, polishes and waxes, finger paints, washing & cleaning products, inks and toners, leather treatment products and non-metal-surface treatment products.

Other release to the environment of n-Butanol is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

N-Butanol is used in the following products: coating products, washing & cleaning products, lubricants and greases, laboratory chemicals, adhesives and sealants and metal working fluids.
N-Butanol is used in the following areas: building & construction work, scientific research and development, printing and recorded media reproduction and health services.
N-Butanol is used for the manufacture of: plastic products, mineral products (e.g. plasters, cement) and furniture.

Other release to the environment of n-Butanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
N-Butanol is used in the following products: coating products, fillers, putties, plasters, modelling clay and inks and toners.
Release to the environment of n-Butanol can occur from industrial use: formulation of mixtures and manufacturing of the substance.

N-Butanol is used in the following products: coating products, washing & cleaning products, lubricants and greases, metal working fluids, laboratory chemicals and fillers, putties, plasters, modelling clay.
N-Butanol has an industrial use resulting in manufacture of another substance (use of intermediates).
N-Butanol is used for the manufacture of: chemicals.

Release to the environment of N-Butanol can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.
Release to the environment of N-Butanol can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and formulation of mixtures.

N-Butanol can be used as a chemical intermediate to create other chemicals (e.g., esters, n-butyl acetate, and amino resins); alternatively, it can be used as a solvent in the creation of consumer products.
N-butanol is used as a solvent for paints, coatings, varnishes, fats, oils, waxes, rubber, and plasticizers.
Other uses include coating fabric in the textiles industry, as a cleaning or polishing agent, gasoline, brake fluid and in consumer products such as make-up, nail products, hygiene products and shaving products in the cosmetic industry.

N-Butanol is primarily used as a solvent in various industries, including the manufacturing of paints, coatings, varnishes, and inks.
N-Butanol is appreciated for its ability to dissolve a wide range of substances.
N-Butanol serves as a precursor in the synthesis of various chemicals, including esters, butyl acrylate, and plasticizers.

In some cases, n-butanol is used as an additive in gasoline to improve its octane rating and reduce emissions.
N-Butanol at 85% can be used in car engines that are designed for gasoline with no engine modification required.
This allows for lower fuel consumption than other gasoline alternatives such as ethanol due to the lower oxygen content of n-butanol.

The chemical is present in several foods and beverages as an artificial flavouring.
N-Butanol is also used in food preparation such as during the manufacture of hop extract for beermaking.
Release to the environment of n-Butanol can occur from industrial use: of articles where the substances are not intended to be released and where the conditions of use do not promote release.

Other release to the environment of n-Butanol is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
N-Butanol can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery) and plastic (e.g. food packaging and storage, toys, mobile phones).

N Butanol is used as a solvent, as an ingredient in various formulations such as cosmetics and as a starting material to produce other chemicals.
N Butanol is primarily used in the coatings industry where it is widely used as a diluent in cellulose nitrate lacquers as it improves their flow, gloss and resistance to blushing.
N-Butanol is suitable for use as a solvent for acid-curable lacquers and baking finishes derived from urea, melamine, or phenolic resins, where it is mainly used together with glycol ethers or ethanol.

N-Butanol is employed as a solvent for paints, lacquers & varnishes, natural & synthetic resins, gums, vegetable oils, dyes & alkaloids.
N-Butanol is used as an intermediate in the manufacture of pharmaceuticals & chemicals, & employed in industries producing artificial leather, textiles, safety glass, rubber cement, shellac, raincoats, photographic films & perfumes.

N-Butanol is used primarily as an industrial intermediate in the production of ethers and butyl ether acetates, pharmaceuticals, polymers and plastics.
N-Butanol is used to a lesser extent as a solvent, reactant/diluent and component in consumer (nail polishn formulations, rubber cement and safety glass) and industrial products.

In some cases, n-butanol is added to gasoline as an octane booster.
N-Butanol can improve the octane rating of gasoline, which can lead to better engine performance and reduced knocking.
N-butanol is used to enhance the aroma of certain perfumes, colognes, and scented products.

N-Butanol is used in the production of household and industrial cleaners and degreasers due to its effective solvent properties.
N-butanol is used in the production of plastics and resins, such as acrylate resins and cellulose acetate butyrate, where it functions as a plasticizer or modifier to improve flexibility and other properties.

N-butanol can be produced through fermentation processes using certain microorganisms, making it a potential candidate for biofuel production.
N-Butanol has been considered as a biofuel alternative due to its energy density and compatibility with existing engines and infrastructure.

In various industries, n-butanol is employed for extraction and purification processes to separate and purify compounds from mixtures.
Although not a direct food additive, n-butanol may be present as a residue in trace amounts in some food products due to its use in food packaging materials.
Regulatory authorities set limits on permissible residue levels for food safety.

N-butanol is widely used as a solvent in the formulation of paints, varnishes, and coatings.
N-Butanol helps to dissolve pigments, resins, and other additives, ensuring that the paint can be applied smoothly and evenly.
N-Butanol also contributes to the drying and curing process in certain types of coatings.

In the printing industry, n-butanol is utilized in the production of inks, including flexographic and gravure printing inks, due to its excellent solvency properties.
N-Butanol aids in achieving the desired viscosity and flow characteristics.
N-butanol is a common ingredient in the manufacturing of adhesives and sealants, where it helps maintain the desired consistency and provides good adhesion properties.

N-Butanol is used as a reaction medium in various chemical processes, such as esterification reactions to produce esters used in perfumes and flavorings.
N-butanol is used as a solvent in the extraction of natural fragrances and flavors, and it may also be found in the final formulations of perfumes, colognes, and food flavorings.

N-Butanol serves as a solvent in the production of pharmaceuticals and can be used in the synthesis of various active pharmaceutical ingredients (APIs).
In addition to being an octane booster in gasoline, n-butanol can also be used as a component in the formulation of automotive fluids, such as brake fluids and hydraulic fluids.

N-butanol can be employed as a plasticizer in the manufacture of plastics and rubber products, helping to improve their flexibility and durability.
As part of efforts to develop sustainable and bio-based fuels, n-butanol has been investigated as a potential biofuel candidate.
N-Butanol can be produced through microbial fermentation processes using biomass feedstocks.

N-butanol may be used in the production of food packaging materials, such as coatings on paper or films, to improve barrier properties and performance.
In laboratories, n-butanol can be used as a solvent for various analytical techniques, including chromatography and spectrophotometry.

N-Butanol is used in the extraction of essential oils from plant materials and herbs for use in aromatherapy and natural products.
N-butanol can be found in some cosmetics and personal care products, including nail polish and hair sprays.
In some industrial applications, n-butanol may be used as a preservative to extend the shelf life of certain products.

The main user end market of N-Butanol is the chemical, petrochemical, textiles, cleaning, and cosmetics industries.
N-butanol is used as a solvent in the textile industry for dyeing and printing fabrics.
N-Butanol helps dissolve dyes and provides even color distribution.

N-Butanol is utilized in the rubber industry as a processing aid and solvent for rubber compounds.
N-butanol is sometimes used as a component in wood coatings and finishes, providing protection and a smooth finish to wood products.
In addition to inks, n-butanol can be found in fountain solutions and press wash solutions in the printing industry to help maintain the quality of printing presses.

While n-butanol itself is not commonly used as a fuel, it is a precursor in the production of biofuels, such as butanol-based biofuels, which have been explored as potential alternatives to traditional fossil fuels.
N-butanol is used as a cleaning agent in the electronics industry to remove contaminants from electronic components and printed circuit boards.

In recent years, there has been an increasing interest in water-based coatings and paints due to environmental considerations.
N-butanol is sometimes used in water-based formulations as a coalescing agent to improve film formation and performance.

In scientific laboratories, n-butanol can be used as a reagent or solvent in various chemical and biochemical experiments.
N-Butanol is used in the extraction and processing of oil and natural gas, particularly in the removal of impurities and as a solvent for certain chemical reactions.
N-butanol has been used as a component in firefighting foams due to its ability to create stable foam and suppress flammable liquid fires.

Some automotive care products, such as windshield washer fluids, may contain n-butanol as a component to help dissolve dirt and improve cleaning efficiency.
In the past, n-butanol was used in the formulation of photographic chemicals, particularly in the development process, although its use in this application has decreased with the transition to digital photography.
N-Butanol can be used in agriculture as an adjuvant in pesticide formulations to improve the effectiveness and adhesion of pesticides to plant surfaces.

Health Hazard:
The toxicity of N-Butanol is lower than thatof its carbon analog.
Target organs are theskin, eyes, and respiratory system.
Inhalationcauses irritation of the eyes, nose, and throat.

N-Butanol was found to cause severe injury to rabbits’eyes and to penetrate the cornea uponinstillation into the eyes.
Chronic exposureof humans to high concentrations may causephotophobia, blurred vision, and lacrimation.
A concentration of 8000 ppm was maternallytoxic to rats, causing reduced weightgain and feed intake.

Teratogenicity wasobserved at this concentration with a slightincrease in skeletal malformations.
In a single acute oral dose, the LD50 value(rats) is 790 mg/kg; in a dermal dose theLD50 value (rabbits) is 4200 mg/kg.
N-Butanol is oxidized in vivo enzymaticallyas well as nonenzymatically and iseliminated rapidly from the body in the urineand in expired air.

N-Butanol inhibits the metabolismof ethanol caused by the enzyme alcoholdehydrogenase.
Based on the available data, the useof n-butanol as an ingredient is consideredsafe under the present practices andconcentrations in cosmetic nail products(Cosmetic, Toiletry and Fragrance Association1987a).

Fire Hazard:
N-Butanol will be easily ignited by heat, sparks or flames.
Vapors may form explosive mixtures with air.
Vapors may travel to source of ignition and flash back.

Most vapors are heavier than air.
They will spread along ground and collect in low or confined areas (sewers, basements, tanks).

Vapor explosion hazard indoors, outdoors or in sewers.
Runoff to sewer may create fire or explosion hazard.

Safety Profile:
A poison by intravenous route.
Contact, ingestion, subcutaneous, and intraperitoneal routes.
Human systemic Reported in EPA TSCA Inventory.

N-Butanol a skin and eye irritant.
N-Butanol a flammable fight fire, use foam, CO2, dry chemical. ,
Incompatible with oxidzing materials.

When heated to decomposition it emits acrid and irritating fumes.
N-Butanol effects by inhalation: conjunctiva irritation, unspecified respiratory system effects, and nasal effects.
Experimental reproductive Though animal experiments have shown the butyl alcohols to possess toxic properties, they have produced few cases of poisoning in industry, probably because of their low reported to have resulted in irritation of the eyes, with corneal inflammation, slight headache and H2ziness, slight irritation of the nose and throat, and dermatitis about fingers.

Synonyms
N-Butanol
butanol
Butan-1-ol
n-butanol
Butyl alcohol
71-36-3
n-butyl alcohol
1-hydroxybutane
Propylcarbinol
Butyl hydroxide
Methylolpropane
Propylmethanol
Hemostyp
Butyric alcohol
1-Butyl alcohol
n-Butan-1-ol
Butanolo
Propyl carbinol
Alcool butylique
Butylowy alkohol
BuOH
Butanolen
Normal primary butyl alcohol
Butanols
RCRA waste number U031
CCS 203
n-Butylalkohol
Alcohol, Butyl
Butyl alcohol (natural)
FEMA No. 2178
FEMA Number 2178
n-Propyl carbinol
1 Butanol
Butanol [French]
Butanolen [Dutch]
Butyric or normal primary butyl alcohol
Butanolo [Italian]
n-BuOH
35296-72-1
HSDB 48
NSC 62782
CCRIS 4321
Alcool butylique [French]
Butylowy alkohol [Polish]
butanol-1
EINECS 200-751-6
UNII-8PJ61P6TS3
Butanol, 1-
8PJ61P6TS3
Butyl alcohol (NF)
Butyl alcohol [NF]
ALCOHOL,BUTYL
DTXSID1021740
CHEBI:28885
AI3-00405
n-Butyl--d6 Alcohol
MFCD00002964
NSC-62782
RCRA waste no. U031
UNII-WB09NY83YA
n-Butyl-1,1-d2 Alcohol
N-Butanol-4,4,4-d3
CHEMBL14245
DTXCID701740
EC 200-751-6
NCGC00090961-02
Tilcom TNBT
Tyzor BP
Butyl orthotitanate
Tyzor BTM
Tyzor TBT
N-Butanol-3,3,4,4,4-D5
Orgatix T 25
Orgatix TA 25
Titanium tetrabutoxy-
BUTYL ALCOHOL (II)
BUTYL ALCOHOL [II]
Titanium tetrabutoxide
Titanium tetrabutylate
Tetra-n-butoxytitanium
Tetra-n-butil titanato
Tetra-n-butyl titanate
Titanium, tetrabutoxy-
32586-14-4
64118-16-7
Tetrabutoxytitanium(IV)
Tetrabutyl orthotitanate
N-Butanol, analytical standard
BUTYL ALCOHOL (MART.)
BUTYL ALCOHOL [MART.]
titanium tetra-n-butoxide
N-Butanol-2,2,3,3,4,4,4-D7
Titanium(IV) n-Butoxide
TETRABUTYL TITANATE
titanato de butilo (IV)
1219794-84-9
C(CC)CO
Tetrakis(butanolato)titanium
VANADIUM TETRABUTOXIDE
n-Butanol, Butan-1-ol, N-Butanol
TBT-B 1
Tetraortotitanato de n-butilo
n Butanol
Titanium tetrakis(1-butoxide)
n Butyl Alcohol
Titanic acid, tetrabutyl ester
N-Butanol, titanium(4) salt
C4H10O.1/4Ti
Titanium butoxide (Ti(OBu)4)
N-Butanol, ACS reagent, >=99.4%
N-Butanol, titanium(4+) salt
CAS-71-36-3
Alcohol, n-Butyl
Butyl titanate(IV) (6CI7CI)
AKT 850
Butyl alcohol, titanium(4) salt
TBT 100
N-Butanol titanium salt (4:1)
N-Butanol, titanium(4++) salt
1BO
Butyl alcohol, titanium(4+) salt
Butyl titanate(IV) ((BuO)4Ti)
C4-H10-O.1/4Ti
N-Butanol, sal de titanio (4 +)
N-Butanol titanium(4+) salt (9CI)
Tetrabutyl titanate; (Butyl titanate)
Butyl alcohol titanium(4+) salt (8CI)
TRIBUTYL ACETYLCITRATE IMPURITY D (EP IMPURITY)
TRIBUTYL ACETYLCITRATE IMPURITY D [EP IMPURITY]
N-Butanol, sal de titanio (4 +) (4:1)
butaneol
butylalcohol
propilcarbinol
butyl-alcohol
n-butylalcohol
normal butanol
1-butylalcohol
n-Propylcarbinol
alcohol n-butilo
n-Butanolbutanolen
nBuOH
1 -butanol
1- butanol
1-n-Butanol
Butyl alcohol, n-
N-Butanol, anhydrous
Butan- 1- ol
Butyl alcohol (8CI)
butan - 1 - ol
N-Butyl Alcohol,(S)
BAN (CHRIS Code)
N-Butanol, for HPLC
n-Butanol, HPLC grade
N-Butanol, 99%
6167-45-9
B 1
N-Butanol, HPLC Grade
n-C4H9OH
bmse000447
N-Butanol (butyl alcohol)
N-Butanol, 99.9%
BUTYL ALCOHOL [FCC]
WB09NY83YA
BUTYL ALCOHOL [FHFI]
BUTYL ALCOHOL [HSDB]
WLN: Q4
butan-1-olate,vanadium(4+)
N-Butanol [USP-RS]
ALCOHOL,BUTYL [VANDF]
BIDD:ER0611
N-BUTYL ALCOHOL [MI]
N-BUTYL ALCOHOL [INCI]
N-Butanol, LR, >=99%
BDBM36173
N-Butanol, anhydrous, 99.8%
N-Butanol, ACS, 99.4+%
N-BUTYL ALCOHOL [WHO-DD]
N-Butanol, AR, >=99.5%
N-Butanol, for HPLC, 99.8%
Butyl alcohol, >=99.9%, FCC
NSC62782
Tox21_111046
Tox21_200741
LMFA05000109
STL264186
AKOS000249218
N-Butanol 500 microg/mL in Methanol
N-Butanol, for HPLC, >=99.7%
DB02145
LS-1603
Butyl alcohol, >=99.9%, FCC, FG
NCGC00090961-01
NCGC00090961-03
NCGC00258295-01
BP-30034
N-Butanol, SAJ first grade, >=99.0%
N-Butanol, for molecular biology, >=99%
N-Butanol, JIS special grade, >=99.0%
N-Butanol, p.a., ACS reagent, 99.4%
N-Butanol, for HPLC, >=99.8% (GC)
N-Butanol, spectrophotometric grade, 99.5%
N-Butanol, UV HPLC spectroscopic, 99.5%
B0228
B0704
B0944
FT-0607555
FT-0623296
FT-0774976
N-Butanol, anhydrous, ZerO2(TM), 99.8%
EN300-19305
N-Butanol, Ultrapure, Spectrophotometric Grade
Butyl alcohol, natural, >=99.5%, FCC, FG
C06142
D03200
Q16391
VOC Mixture 582 2000 microg/mL in Methanol
F0001-1830
InChI=1/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H
N-Butanol, puriss. p.a., ACS reagent, >=99.5% (GC)
BDBC6468-886D-4F6C-8746-734F2B63E6CE
N-Butanol, ACS reagent, reag. ISO, reag. Ph. Eur., 99.5%
N-Butanol, United States Pharmacopeia (USP) Reference Standard
N-Butanol, Pharmaceutical Secondary Standard; Certified Reference Material
N-Butanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5% (GC)

Tetrasodium (1-hydroxyethylidene)bisphosphonate; Tetra Sodium Salt of 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid; ETIDRONIC ACID, TETRASODIUM SALT; 1-Hydroxyethane-1,1-diphosphonic acid , Tetrasodium salt; 1-Hydroxyethylidene-1,1-diphosphonic acid, Tetrasodium salt; Sodium HEDP; HEDPS; 1-hydroxyethylidenedi(phosphonic acid), Tetrasodium salt; (Hydroxyethylidene) diphosphonic acid, Tetrasodium salt; Tetra Sodium Salt of 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid CAS NO:3794-83-0

DESCRIPTION:
N-Butyl Alcohol, also known as butan-1-ol or n-butanol, is a primary alcohol with the chemical formula C4H9OH and a linear structure.
Isomers of 1-butanol are isobutanol, butan-2-ol and tert-butanol.
The unmodified term butanol usually refers to the straight chain isomer.

CAS Number: 71-36-3
EC Number: 200-751-6
Molecular Formula: C4H10O


N-Butyl Alcohol occurs naturally as a minor product of the ethanol fermentation of sugars and other saccharides and is present in many foods and drinks.
N-Butyl Alcohol is also a permitted artificial flavorant in the United States, used in butter, cream, fruit, rum, whiskey, ice cream and ices, candy, baked goods, and cordials.
N-Butyl Alcohol is also used in a wide range of consumer products.

The largest use of 1-butanol is as an industrial intermediate, particularly for the manufacture of butyl acetate (itself an artificial flavorant and industrial solvent).
N-Butyl Alcohol is a petrochemical derived from propylene.
Estimated production figures for 1997 are: United States 784,000 tonnes; Western Europe 575,000 tonnes; Japan 225,000 tonnes.



N-butyl alcohol is a colorless liquid. Used in organic chemical synthesis, plasticizers, detergents, etc.
N-butyl alcohol is a primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group.
N-butyl alcohol is produced in small amounts in humans by the gut microbes.

N-butyl alcohol has a role as a protic solvent, a human metabolite and a mouse metabolite.
N-butyl alcohol is a primary alcohol, a short-chain primary fatty alcohol and an alkyl alcohol.
N-butyl alcohol is a natural product found in Vitis rotundifolia, Cichorium endivia, and other organisms with data available.


n-Butyl Alcohol or n-Butanol or normal butanol is a primary alcohol with a 4-carbon structure and the chemical formula C4H9OH.
Its isomers include isobutanol, 2-butanol, and tert-butanol.
Butanol is one of the group of “fusel alcohols” (from the German for “bad liquor”), which have more than two carbon atoms and have significant solubility in water.

n-Butyl Alcohol occurs naturally as a minor product of the fermentation of sugars and other carbohydrates, and is present in many foods and beverages.
n-Butyl Alcohol is also a permitted artificial flavorant in the United States, used in butter, cream, fruit, rum, whiskey, ice cream and ices, candy, baked goods and cordials.
n-Butyl Alcohol is also used in a wide range of consumer products.


PRODUCTION OF N-BUTYL ALCOHOL:
Since the 1950s, most 1-butanol is produced by the hydroformylation of propene (oxo process) to preferentially form the butyraldehyde n-butanal.
Typical catalysts are based on cobalt and rhodium.

Butyraldehyde is then hydrogenated to produce butanol.


A second method for producing butanol involves the Reppe reaction of propylene with CO and water:
CH3CH=CH2 + H2O + 2 CO → CH3CH2CH2CH2OH + CO2
In former times, butanol was prepared from crotonaldehyde, which can be obtained from acetaldehyde.


N-Butyl Alcohol can also be produced by fermentation of biomass by bacteria.
Prior to the 1950s, Clostridium acetobutylicum was used in industrial fermentation to produce butanol.
Research in the past few decades showed results of other microorganisms that can produce butanol through fermentation.

Butanol can be produced via furan hydrogenation over Pd or Pt catalyst at high temperature and high pressure.

INDUSTRIAL USE OF N-BUTYL ALCOHOL:
Constituting 85% of its use, 1-butanol is mainly used in the production of varnishes.
N-Butyl Alcohol is a popular solvent, e.g. for nitrocellulose.
A variety of butanol derivatives are used as solvents, e.g. butoxyethanol or butyl acetate.

Many plasticizers are based on butyl esters, e.g., dibutyl phthalate.
The monomer butyl acrylate is used to produce polymers.
It is the precursor to n-butylamines.

Biofuel:
N-Butyl Alcohol has been proposed as a substitute for diesel fuel and gasoline.
N-Butyl Alcohol is produced in small quantities in nearly all fermentations (see fusel oil).
Clostridium produces much higher yields of butanol.

Research is underway to increase the biobutanol yield from biomass.
Butanol is considered as a potential biofuel (butanol fuel).
Butanol at 85 percent strength can be used in cars designed for gasoline without any change to the engine (unlike 85% ethanol), and it provides more energy for a given volume than ethanol, almost as much as gasoline.

Therefore, a vehicle using butanol would return fuel consumption more comparable to gasoline than ethanol.
Butanol can also be added to diesel fuel to reduce soot emissions.

The production of, or in some cases, the use of, the following substances may result in exposure to 1-butanol: artificial leather, butyl esters, rubber cement, dyes, fruit essences, lacquers, motion picture, and photographic films, raincoats, perfumes, pyroxylin plastics, rayon, safety glass, shellac varnish, and waterproofed cloth.

OCCURRENCE IN NATURE:
N-Butyl Alcohol occurs naturally as a result of carbohydrate fermentation in a number of alcoholic beverages, including beer, grape brandies, wine, and whisky.
N-Butyl Alcohol has been detected in the volatiles of hops, jack fruit, heat-treated milks, musk melon, cheese, southern pea seed, and cooked rice.
N-Butyl Alcohol is also formed during deep frying of corn oil, cottonseed oil, trilinolein, and triolein.

N-Butyl Alcohol is one of the "fusel alcohols" (from the German for "bad liquor"), which include alcohols that have more than two carbon atoms and have significant solubility in water.
N-Butyl Alcohol is a natural component of many alcoholic beverages, albeit in low and variable concentrations.
N-Butyl Alcohol (along with similar fusel alcohols) is reputed to be responsible for severe hangovers, although experiments in animal models show no evidence for this.


N-Butyl Alcohol is used as an ingredient in processed and artificial flavorings, and for the extraction of lipid-free protein from egg yolk, natural flavouring materials and vegetable oils, the manufacture of hop extract for beermaking, and as a solvent in removing pigments from moist curd leaf protein concentrate.



APPLICATIONS OF N-BUTYL ALCOHOL:
N-Butyl Alcohol is used predominately as an industrial intermediate.
For example, N-Butyl Alcohol is used to make butyl acetate and other butyl esters; butyl ethers, such as ethylene glycol monobutyl ether, di- and triethylene glycol monobutyl ether, and the corresponding butyl ether acetates.
N-Butyl Alcohol is used to manufacture dibutyl phthalate, pharmaceuticals, polymers, pyroxylin plastics, butyl xanthate and other butyl compounds.

N-Butyl Alcohol is used as a diluent/reactant in the manufacture of urea/formaldehyde and melamine/formaldehyde resins.
When used as an industrial intermediate, butyl alcohol is consumed by chemical conversion to the desired product.
N-Butyl Alcohol is used to a lesser extent as a solvent and in formulations to make, dyes, lacquers (including cellulose lacquers), resins and varnishes.

N-Butyl Alcohol is a component in some nail polish formulations.
N-Butyl Alcohol is used to make rubber cement, safety glass, rayon, waterproofed cloth, artificial leather, raincoats, motion picture and photographic film.
N-Butyl Alcohol is used as a softener in the fabrication of cellulose nitrate plastics









CHEMICAL AND PHYSICAL PROPERTIES OF N-BUTYL ALCOHOL:
Chemical formula C4H10O
Molar mass 74.123 g•mol−1
Appearance Colourless, refractive liquid
Odor banana-like, harsh, alcoholic and sweet
Density 0.81 g/cm3
Melting point −89.8 °C (−129.6 °F; 183.3 K)
Boiling point 117.7 °C (243.9 °F; 390.8 K)
Solubility in water 73 g/L at 25 °C
Solubility very soluble in acetone
miscible with ethanol, ethyl ether
log P 0.839
Vapor pressure 0.58 kPa (20 °C) ILO International Chemical Safety Cards (ICSC)
Acidity (pKa) 16.10
Magnetic susceptibility (χ) −56.536•10−6 cm3/mol
Refractive index (nD) 1.3993 (20 °C)
Viscosity 2.573 mPa•s (at 25 °C)
Dipole moment 1.66 D
Thermochemistry
Std molar entropy (S⦵298) 225.7 J/(K•mol)
Std enthalpy of formation (ΔfH⦵298) −328(4) kJ/mol
Std enthalpy of combustion (ΔcH⦵298) −2670(20) kJ/mol
Molecular Weight
74.12 g/mol
XLogP3
0.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
2
Exact Mass
74.073164938 g/mol
Monoisotopic Mass
74.073164938 g/mol
Topological Polar Surface Area
20.2Ų
Heavy Atom Count
5
Formal Charge
0
Complexity
13.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Substance name:1-butanol
Trade name:n-Butyl Alcohol
EC no:200-751-6
CAS no:71-36-3
HS code:29051300
KH product code:100012
Formula:C4H10O
Cas Number: 71-36-3
Molecular Formula: C4H10O
Synonyms: butan-1-ol, 1-butanol, normal butanol, and n-butyl alcohol
Molecular Mass: 74.12
Flashpoint (closed cup): 29 °C (84.2 °F)
Autoignition temperature: 343 °C (649.4 °F)
Boiling Point: 117 °C (242.6 °F)
Melting Point: -90 °C (-130 °F)
Vapour Pressure: 0.58 kPa at 20 °C (68 °F)
Density: 0.81 at 20 °C (68 °F)
Log P: 0.88

SAFETY INFORMATION ABOUT N-BUTYL ALCOHOL:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product








SYNONYMS OF N-BUTYL ALCOHOL:
1 Butanol
1-Butanol
Alcohol, Butyl
Alcohol, n-Butyl
Butyl Alcohol
n Butanol
n Butyl Alcohol
n-Butanol
n-Butyl Alcohol
1-butanol
butanol
Butan-1-ol
n-butanol
Butyl alcohol
71-36-3
n-butyl alcohol
1-hydroxybutane
Propylcarbinol
Butyl hydroxide
Methylolpropane
Propylmethanol
Hemostyp
Butyric alcohol
1-Butyl alcohol
n-Butan-1-ol
Butanolo
Propyl carbinol
Alcool butylique
Butylowy alkohol
BuOH
Butanolen
Normal primary butyl alcohol
RCRA waste number U031
CCS 203
n-Butylalkohol
Alcohol, Butyl
Butyl alcohol (natural)
FEMA No. 2178
FEMA Number 2178
1 Butanol
Butyric or normal primary butyl alcohol
n-BuOH
35296-72-1
HSDB 48
NSC 62782
CCRIS 4321
butanol-1
EINECS 200-751-6
UNII-8PJ61P6TS3
8PJ61P6TS3
Butyl alcohol (NF)
Butyl alcohol [NF]
ALCOHOL,BUTYL
DTXSID1021740
CHEBI:28885
AI3-00405
n-Butyl--d6 Alcohol
MFCD00002964
NSC-62782
n-Butyl-1,1-d2 Alcohol
1-Butanol-4,4,4-d3
CHEMBL14245
DTXCID701740
EC 200-751-6
NCGC00090961-02
Butanols
1-BUTANOL-3,3,4,4,4-D5
BUTYL ALCOHOL (II)
BUTYL ALCOHOL [II]
n-Propyl carbinol
Butanol [French]
Butanolen [Dutch]
1219794-84-9
64118-16-7
Butanolo [Italian]
1-Butanol, analytical standard
BUTYL ALCOHOL (MART.)
BUTYL ALCOHOL [MART.]
1-BUTANOL-2,2,3,3,4,4,4-D7
32586-14-4
VANADIUM TETRABUTOXIDE
n-Butanol, Butan-1-ol, 1-Butanol
n Butanol
n Butyl Alcohol
Alcool butylique [French]
Butylowy alkohol [Polish]
1-Butanol, ACS reagent, >=99.4%
CAS-71-36-3
Alcohol, n-Butyl
1BO
Butanol, 1-
TRIBUTYL ACETYLCITRATE IMPURITY D (EP IMPURITY)
TRIBUTYL ACETYLCITRATE IMPURITY D [EP IMPURITY]
RCRA waste no. U031
UNII-WB09NY83YA
butaneol
butylalcohol
butyl-alcohol
n-butylalcohol
normal butanol
1-butylalcohol
n-Propylcarbinol
n-Butanolbutanolen
nBuOH
1 -butanol
1- butanol
1-n-Butanol
1-Butanol, anhydrous
N-Butyl Alcohol,(S)
1-Butanol, for HPLC
n-Butanol, HPLC grade
1-Butanol, 99%
6167-45-9
1-Butanol, HPLC Grade
n-C4H9OH
bmse000447
1-butanol (butyl alcohol)
1-Butanol, 99.9%
BUTYL ALCOHOL [FCC]
WB09NY83YA
BUTYL ALCOHOL [FHFI]
BUTYL ALCOHOL [HSDB]
WLN: Q4
butan-1-olate,vanadium(4+)
1-BUTANOL [USP-RS]
ALCOHOL,BUTYL [VANDF]
BIDD:ER0611
N-BUTYL ALCOHOL [MI]
N-BUTYL ALCOHOL [INCI]
1-Butanol, LR, >=99%
BDBM36173
1-Butanol, anhydrous, 99.8%
N-Butanol, ACS, 99.4+%
N-BUTYL ALCOHOL [WHO-DD]
1-Butanol, AR, >=99.5%
1-Butanol, for HPLC, 99.8%
Butyl alcohol, >=99.9%, FCC
NSC62782
Tox21_111046
Tox21_200741
LMFA05000109
STL264186
AKOS000249218
1-Butanol 500 microg/mL in Methanol
1-Butanol, for HPLC, >=99.7%
DB02145
Butyl alcohol, >=99.9%, FCC, FG
NCGC00090961-01
NCGC00090961-03
NCGC00258295-01
BP-30034
1-Butanol, SAJ first grade, >=99.0%
1-Butanol, for molecular biology, >=99%
1-Butanol, JIS special grade, >=99.0%
1-Butanol, p.a., ACS reagent, 99.4%
1-Butanol, for HPLC, >=99.8% (GC)
1-Butanol, spectrophotometric grade, 99.5%
1-Butanol, UV HPLC spectroscopic, 99.5%
B0228
B0704
B0944
FT-0607555
FT-0623296
FT-0774976
1-Butanol, anhydrous, ZerO2(TM), 99.8%
EN300-19305
1-Butanol, Ultrapure, Spectrophotometric Grade
Butyl alcohol, natural, >=99.5%, FCC, FG
C06142
D03200
Q16391
F0001-1830
InChI=1/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H
1-Butanol, puriss. p.a., ACS reagent, >=99.5% (GC)
BDBC6468-886D-4F6C-8746-734F2B63E6CE
1-Butanol, ACS reagent, reag. ISO, reag. Ph. Eur., 99.5%
1-Butanol, United States Pharmacopeia (USP) Reference Standard
1-Butanol, Pharmaceutical Secondary Standard; Certified Reference Material
1-Butanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5% (GC)

n-BUTYL MERCAPTAN = 1-BUTANETHIOL


CAS Number: 109-79-5
EC Number: 203-705-3
MDL: MFCD00004905
Molecular Formula: C4H10S or CH3(CH2)3SH


n-butyl mercaptan is a colorless, flowable liquid with a special thiol odor.
n-butyl mercaptan is slightly soluble in water, very soluble in alcohol, ether.
n-butyl mercaptan's relative density is 0. 8337 (20 ℃), melting point -115.7 ℃, boiling point 98.4 ℃, refractive index 1.444, flash point 12 ℃.
n-butyl mercaptan, also known as butyl mercaptan, is a highly volatile, clear to yellowish liquid with a foetid (extremely foul-smelling) odor, commonly described as "skunk" odor.


In fact, n-butyl mercaptan is one of the major constituents of a skunk's defensive spray.
The scent of n-butyl mercaptan is so strong that the human nose can easily detect it in the air at concentrations as low as 10 parts per billion.
n-butyl mercaptan is chemically classified among the thiols, which are organic compounds with molecular formulas and structural formulas similar to alcohols, except that sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group in the molecule.


n-butyl mercaptan's basic molecular formula is C4H9SH, and its structural formula is similar to that of the alcohol butanol.
n-butyl mercaptan is a thiol of low molecular weight.
n-butyl mercaptan is colorless to light yellow liquid.
n-butyl mercaptan is diluted (<0.02mg/kg) fat, stewed beef, tender boiled onions, eggs, coffee, garlic-like aroma.


n-butyl mercaptan's boiling point is 97~98.4 deg C.
n-butyl mercaptan is slightly soluble in oil, slightly soluble in water (0.6g/100 m1), soluble in ethanol.
n-butyl mercaptan is found in cheese, boiled eggs, boiled or fried beef, beer, etc.
n-butyl mercaptan is a colorless to yellow liquid with a strong,
skunk-like odor.


n-butyl mercaptan is colorless liquid with a strong, garlic-, cabbage-, or skunk-like odor.
n-butyl mercaptan is a volatile, clear to yellowish liquid with a fetid (extremely foul-smelling) odor, commonly described as "skunk" odor.
In fact, n-butyl mercaptan is structurally similar to several major constituents of a skunk's defensive spray but is not actually present in the spray.


The scent of n-butyl mercaptan is so strong that the human nose can easily detect it in the air at concentrations as low as 10 parts per billion.
The threshold level for n-butyl mercaptan is reported as 1.4 ppb
n-butyl mercaptan's basic molecular formula is C4H9SH, and its structural formula is similar to that of the alcohol n-butanol.


n-butyl mercaptan is prepared by the free radical catalyzed addition of hydrogen sulfide to 1-butene.
Commercially, this is performed using ultraviolet light.
n-butyl mercaptan is a thiol of low molecular weight.
n-butyl mercaptan appears as a clear, colorless liquid with a strong skunk-like odor.


n-butyl mercaptan is less dense than water and slightly soluble in water.
n-butyl mercaptan's vapors is heavier than air.
n-butyl mercaptan is an alkanethiol.
n-butyl mercaptan is a natural product found in Mephitis mephitis with data available.


n-butyl mercaptan is chemically classified among the thiols, which are organic compounds with molecular formulas and structural formulas similar to alcohols, except that the sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group (-OH) in the molecule.
n-butyl mercaptan, also known as 1-butyl mercaptan or 1-butylthiol, belongs to the class of organic compounds known as alkylthiols.
These are organic compounds containing the thiol functional group linked to an alkyl chain.


n-butyl mercaptan is a coffee, egg, and garlic tasting compound.
n-butyl mercaptan has been detected, but not quantified, in milk and milk products and potato.
Commercially, this is performed using ultraviolet light.
The threshold level for n-butyl mercaptan is reported as 1.4 ppb.


n-butyl mercaptanis prepared by the free radical catalyzed addition of hydrogen sulfide to 1-butene.
n-butyl mercaptan belongs to the class of organic compounds known as alkylthiols.
These are organic compounds containing the thiol functional group linked to an alkyl chain.



USES and APPLICATIONS of n-BUTYL MERCAPTAN:
n-butyl mercaptan is used as an industrial solvent,[citation needed] and as an intermediate for cotton defoliants.
n-butyl mercaptan is sometimes placed in the "stink bombs" and "stink perfumes" for pranksters.
n-butyl mercaptan is used as a solvent.
n-butyl mercaptan is used as a solvent, an odorant for natural gas, and an intermediate for insecticides and herbicides.


n-butyl mercaptan is typically used as a solvent and an intermediate in pesticide production.
n-butyl mercaptan is used as an odourant for natural gas due to its recognisably disagreeable odour at extremely low concentrations (0.0001–0.001 ppm).
n-butyl mercaptan is used as an industrial solvent, as an odorant for natural gas (which is odorless), and as an intermediate for insecticides and herbicides.


n-butyl mercaptan is sometimes placed in the "stink bombs" and "stink perfumes" that pranksters love to use.
n-butyl mercaptan is a yellowish liquid with strong odor used as an industrial solvent and intermediate in food nutritional applications as well as flavour and fragrance intermediate, agrochemical intermediates to maintain fertile land, grow crops and raise healthy livestock.
Mixing with other products, n-butyl mercaptan is also used to formulate a cleaning product capable of removing iron scales from metal surfaces in steam generating equipment.


Where water is circulated, and heat transfer occurs, water insoluble salts deposit on the metalic surfaces, therefore, steam generators equipment such as steam boilers, feed water heaters, piping and heat exchangers, can benefit from cleaner compositions that include n-butyl mercaptan since it is useful for removing scale from metal surfaces.
n-butyl mercaptan is sometimes placed in the "stink bombs" and "stink perfumes" for pranksters.
n-butyl mercaptanis used as an industrial solvent, and as an intermediate for cotton defoliants.


-Food and Nutrition Applications of n-butyl mercaptan:
n-butyl mercaptan helps the agricultural industry flourish in its efforts to maintain fertile land, grow crops and raise healthy livestock.


-Applications of n-butyl mercaptan:
*Agrochemicals
*Chemical Intermediate
*Flavor & Fragrance



ALTERNATIVE PARENTS of n-BUTYL MERCAPTAN:
*Hydrocarbon derivatives



SUBSTITUENTS of n-BUTYL MERCAPTAN:
*Alkylthiol
*Hydrocarbon derivative
*Aliphatic acyclic compound



PHYSICAL and CHEMICAL PROPERTIES of n-BUTYL MERCAPTAN:
Molecular Weight: 90.19
XLogP3: 2.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 2
Exact Mass: 90.05032149
Monoisotopic Mass: 90.05032149
Topological Polar Surface Area: 1 Ų
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 13.1
Isotope Atom Count: 0

Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.83800 to 0.84800 @ 25.00 °C.
Pounds per Gallon - (est).: 6.973 to 7.056

Refractive Index: 1.43600 to 1.44600 @ 20.00 °C.
Melting Point: -116.00 °C. @ 760.00 mm Hg
Boiling Point: 98.50 °C. @ 760.00 mm Hg
Vapor Pressure: 45.500000 mmHg @ 25.00 °C.
Vapor Density: 3.1 ( Air = 1 )
Flash Point: 55.00 °F. TCC ( 12.78 °C. )
logP (o/w): 2.280
Soluble in: oils, slightly; water, 597 mg/L @ 20 °C (exp)
Physical description: Colorless liquid with a strong, garlic-, cabbage-, or skunk-like odor.

Boiling point: 209°F
Molecular weight: 90.2
Freezing point/melting point: 176.2°F
Vapor pressure: 35 mmHg
Flash point: 55°F
Specific gravity: 0.83
Ionization potential: 9.15 eV
NFPA health rating: 1
NFPA fire rating: 3

Density: 0.842 g/mL
Molar volume: 107.2 mL/mol
Refractive index: 1.443
Molecular refractive power: 28.38 mL/mol
Dielectric constant: 4.95
Dipole moment: 1.53 D
Melting point: -116 °C
Boiling point: 98 °C
Vapour pressure: 6 Torr
Surface tension: 25.57 dyn/cm
Critical pressure: 3.9 atm
Log10 partition octanol / water: 2.28

Formula: C4H10S
Gas Response Factor, 11.7 eV: 0.5
Gas Response Factor, 10.6 eV: 0.8
Gas Response Factor, 10.0 eV: 0.8
ppm per mg/m⁻³, (20 °C, 1 bar): 0.267
Molecular Weight, g/mole: 90.2
Melting point, °C: -116
Boiling point, °C: 98
Flash point, °C: 1

Upper Explosive Limit, %: 11.3
Lower Explosive Limit, %: 1.4
Density, g.cm⁻³: 0.842
Ionisation Energy, eV: 9.15
NIOSH ceiling, ppm: 0.5
NIOSH ceiling, mg.m⁻³: 1.8
NIOSH IDLH, ppm: 500
OSHA TWA PEL, ppm: 10
OSHA TWA PEL, mg.m⁻³: 35
Density : 0.84
Melting point: -116 ºC

Boiling point: 98 ºC
Refractive index: 1.442-1.444
Flash point: 12 ºC
Water solubility: 0.60 g/100 mL.
Slightly soluble
Appearance Form: clear, liquid
Color: colorless
Odor: No data available
Odor Threshold: No data available
pH: No data available

Melting point/freezing point:
Melting point/range: -116 °C - lit.
Initial boiling point and boiling range: 98 °C - lit.
Flash point: 12 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 111 hPa at 37,7 °C
Vapor density: 3,11 - (Air = 1.0)
Density: 0,842 g/cm3 at 25 °C - lit.
Relative density: No data available

Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Relative vapor density: 3,11 - (Air = 1.0)



FIRST AID MEASURES of n-BUTYL MERCAPTAN:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Do not induce vomiting.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of n-BUTYL MERCAPTAN:
-Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations.



FIRE FIGHTING MEASURES of n-BUTYL MERCAPTAN:
-Extinguishing media:
*Suitable extinguishing media:
Dry powder
Dry sand
-Further information:
Use water spray to cool unopened containers.



EXPOSURE CONTROLS/PERSONAL PROTECTION of n-BUTYL MERCAPTAN:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
-Personal protective equipment:
*Eye/face protection:
Use face shield and safety glasses
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 120 min
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of n-BUTYL MERCAPTAN:
-Precautions for safe handling:
*Advice on safe handling:
Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.
*Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store in cool place.



STABILITY and REACTIVITY of n-BUTYL MERCAPTAN:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available



SYNONYMS:
1-Butanethiol
Butanethiol
butane-1-thiol
109-79-5
BUTYL MERCAPTAN
n-Butyl mercaptan
n-Butanethiol
Butylthiol
Thiobutyl alcohol
n-Butylmercaptan
1-Mercaptobutane
1-Butyl mercaptan
butylmercaptan
n-Butyl thioalcohol
n-Butylthiol
Bear skunk
Normal butyl thioalcohol
Mercaptan C4
FEMA No. 3478
NCI-C60866
n-C4H9SH
77OY909F30
Caswell No. 119D
n-butane-1-thiol
HSDB 290
EINECS 203-705-3
EPA Pesticide Chemical Code 125001
BRN 1730908
butane thiol
n-butanthiol
n-butyl mercaptan, sodium salt
AI3-22954
4-butanethiol
1-butylthiol
butyl thioalcohol
1-butylmercaptan
n-butyl mercaptan, lithium salt
UNII-77OY909F30
n-butyl mercaptan, Ag(+1) salt
n-butyl mercaptan, potassium salt
n-butyl mercaptan, tin (+2) salt
n-BuSH
n-butyl mercaptan, lead (+2) salt
MFCD00004905
BUSH
n-butyl mercaptan, copper (+1) salt
n-butyl mercaptan, silver (+2) salt
n-butyl mercaptan, geranium (+2) salt
n-butyl mercaptan, molybdenum (+3) salt
1-Butanethiol, 99%
DSSTox_CID_6824
BUTYLMERCAPTAN, N-
UN 2347 (Related)
n-butyl mercaptan, 14C,1-(35)S-labeled cpd
1-Butanethiol, >=98%
DSSTox_RID_78221
DSSTox_GSID_26824
4-01-00-01555
1-BUTANETHIOL
n-butyl mercaptan, 2-(14)C,2-(35)s-labeled cpd
N-BUTYL MERCAPTAN
CHEMBL3188256
DTXSID6026824
n-butyl mercaptan, 1,2-(14)C,2-(35) S-labeled cpd
FEMA 3478
1-BUTYL MERCAPTAN
CHEBI:177389
1-Butanethiol, analytical standard
ZINC4706588
Tox21_200811
AKOS009031443
NCGC00248839-01
NCGC00258365-01
CAS-109-79-5
1-Butanethiol, purum, >=97.0% (GC)
DB-003605
B0685
FT-0607554
A802088
Q195823
J-002332
butanethiol
1-butanethiol
n-butanethiol
1-mercaptobutane
butane-1-thiol
butanethiol
1-butanethiol
n-butanethiol
1-mercaptobutane
butane thiol
thiobytyl alcohol
1-Mercaptobutane
Bear skunk
Butanethiol
Butyl mercaptan
Butylthiol
Normal butyl thioalcohol
Thiobutyl alcohol
n-Butanethiol
n-Butyl mercaptan
n-Butyl thioalcohol
n-Butylmercaptan
UN2347
Bear skunk
Butanethiol
n-Butanethiol
1-butanethiol
n-butanethiol
Butane-1-thiol
Butyl Mercaptan
1-mercaptobutane
N-BUTYL MERCAPTAN
n-Butyl Mercaptan
THIOBUTYL ALCOHOL
1-butanethiol[qr]
n-Butyl Thioalcohol
n-Butyl thioalcohol
sodium butane-1-thiolate
tin(2+) dibutane-1-thiolate
n-butylmercaptan
1-Butanethiol
Thiobutyl alcohol
n-butyl mercaptan
Thiobutyl alcohol
n-Butanethiol
N-BUTYL THIOALCOHOL
NCI-C60866
NORMAL BUTYL THIOALCOHOL

N-Cyclohexyl-2-benzothiazole sulfenamide is a rubber accelerator chemical.
N-Cyclohexyl-2-benzothiazole sulfenamide is a multi-walled carbon molecule with an aromatic hydrocarbon cross-linker.


CAS Number: 95-33-0
EC Number: 202-411-2
MDL Number: MFCD00022872
Molecular Formula: C13H16N2S2



SYNONYMS:
2-(Cyclohexylaminothio)benzothiazole, Accelerator CZ, AccicureHBS, Banac CBS, Benzothiazyl-2-cyclohexylsulfenamide, CBS, CBS (accelerator), CBTS, Conac A, Conac S, Delac S, Ekagom CBS, N-Cyclohexyl-2-benzothiazolesulfenamide, N-Cyclohexyl-2-benzothiazolylsulphenamide, N-Cyclohexyl-2-benzothiazylsulfenamide, N-Cyclohexylbenzothiazole-2-sulphenamide, NSC 4809, Nocceler CZ-G, Nocceler CZ-P, Pennac CBS, Rhodifax 16, Accel CZ, 2-Benzothiazolesulfenic acid N-cyclohexylamide, Sanceler CM, Royal CBTS, Sanceler CM-G, Santocure, Santocure CBS, Sulfenamide Ts, Sulfenax, SulfenaxCB, Sulfenax CB 30, Vulkacit C, Vulkacit CZ/C, Vulkacit CZ/EG, Vulkacit CZ/EG-C, NSC 4809, Nocceler CZ, Accelerator CZ, Accicure HBS, N-Cyclohexyl-2-benzothiazolylsulfenamide, Accelerator CZ, N-cyclohexyl-2-benzothiazole Sulfenamide, CBS, 2-(cyclohexylaminothio)benzothiazole, accicurehbs, benzothiazyl-2-cyclohexylsulfenamide, conaca, conach, conacs, curax, cyclohexyl-2-benzothiazolesulfenamide, delacs, ekagomcbs, n-cyclohexyl-2-benzenethiazolesulfenamid, n-cyclohexyl-2-benzothiazolesulfenamid, n-cyclohexyl-2-benzothiazylsulfenamide, noccelercz, pennaccbs, rhodifax16, royalcbts, sancelercm-po, N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine, Acelerator CZ, Rubber Accelerator CBS, Rubber Accelerator CZ, ACCELERATOR CBS (CZ), ACCELERATOR CBS, CBS, accelerator cz, n-cyclohexylbenzothiazole-2-sulfenamide, curax, DURAX, conaca, conach, conacs, delacs, sulfenax, N-Cyclohexyl-2-benzothiazole sulfonamide, N,N'-bis-(1,4-dimethyl-pentyl)-p-phenylenediamine, N-Cyclohexylbenzothiazyl sulfenamide, CBTS, CBS, Cyclohexylbenzothiazyl sulfenamide, N-Cyclohexyl-2-benzothiazyl sulfenamide, Santocure, N,N'-bis(1,4-dimethylpentyl) 1,4-benzenediamine, N,N-di(1,4-dimethylpentyl)-p-phenylenediamine, eastozone 33, eastozone, tenamene, santoflex 77, Vulkanox 4030, AKROCHEM CBTS, ACCELERATOR, CBTS, Sufenax CB, CAS-95-33-0, SMR001798878, CCRIS 4910, HSDB 2868, NSC 4809, EINECS 202-411-2, UNII-UCA53G94EV, BRN 0192376, AI3-16782, Vulkacit cz/eg, Perkacit CBS, Akrochem CBTS, Ekaland CBS, Sanceler CM-G, Banac CBS, Vulkacit CZ/EG-C, CBS, N-Cyclohexyl-2-benzothiazolesulfenamide, EC 202-411-2, SCHEMBL80270, 4-27-00-01867 (Beilstein Handbook Reference), MLS004773968, MLS006010082, CHEMBL1591074, DEQZTKGFXNUBJL-UHFFFAOYSA-, NSC4809, Cyclohexylbenzothiazyl sulphenamide, Cyclohexylbenzothiazolylsulphenamide, Cyclohexyl benzothiazole sulfenamide, N-Cyclohexylbenzothiazoylsulfenamide, N-Cyclohexylbenzothiazyl sulphenamide, Tox21_111721, Tox21_202436, Tox21_302924, MFCD00022872, AKOS003658709, N-Cyclohexyl-2-benzthiazyl sulfenamide, N-Cyclohexyl-2-benzthiazyl sulfonamide, DB14200, HY-W020755, WLN: T56 BN DSJ CSM- AL6TJ, N-Cyclohexyl-2-benzothiazolylsulfonamide, N-Cyclohexyl-2-benzothiazyl sulphenamide, NCGC00159502-03, NCGC00159502-04, NCGC00256366-01, NCGC00259985-01, AS-15575, DB-057577, N-CYCLOHEXYLBENZOTHIAZYL-SULPHENAMIDE, CS-0040170, NS00006793, E80913, EN300-7402242, 2-(CYCLOHEXYLAMINOTHIO)BENZOTHIAZOLE [HSDB], Q4445828, W-100165, BRD-K64191834-001-03-1, S-(1,3-Benzothiazol-2-yl)-N-cyclohexylthiohydroxylamine, S-(1,3-Benzothiazol-2-yl)-N-cyclohexylthiohydroxylamine [(3aS,4R,9S,10aS)-2-amino-5,10,10-trihydroxy-6-imino-9-sulfooxy-3a,4,8,9-tetrahydro-1H-pyrrolo[1,2-c]purin-4-yl]methoxycarbonylsulfamic acid, InChI=1/C13H16N2S2/c1-2-6-10(7-3-1)15-17-13-14-11-8-4-5-9-12(11)16-13/h4-5,8-10,15H,1-3,6-7H2, 95-33-0, N-Cyclohexyl-2-benzothiazolesulfenamide, Thiohexam, N-Cyclohexyl-2-benzothiazolylsulfenamide, Sulfenax, Accelerator CZ, Vulkacit CZ, Santocure, Curax, Durax, Sulfenamide Ts, Santocure Powder, Sulfenax TsB, Vulkacite CZ, Sulfenax CB, Santocure Pellets, Vulcafor CBS, Conac A, Conac S, Delac S, Ekagom CBS, Royal CBTS, Rhodifax 16, Sulfenax CB 30, Vulcafor hbs, Soxinol cz, Vulkacit c, Sulfenax cb/k, Vulkacit cz/c, Vulkacit cz/k, Nocceler CZ, Accicure HBS, N-Cyclohexyl-2-benzothiazylsulfenamide, Pennac CBS, Sanceler CM-PO, 2-(Cyclohexylaminothio)benzothiazole, 2-Benzothiazolesulfenamide, N-cyclohexyl-, Benzothiazyl-2-cyclohexylsulfenamide, N-Cyclohexylbenzothiazole-2-sulfenamide, N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine, N-Cyclohexyl-2-benzothiazosulfenamide, N-Cyclohexyl-2-benzothiazole sulfenamide, Cyclohexyl benzothiazolesulfenamide, Santocure vulcanization accelerator, CBTS, N-Cyclohexylbenzothiazole-2-sulphenamide, 2-Benzenethiazolesulfenamide, N-cyclohexyl-, UCA53G94EV, DTXSID5020360, NSC-4809, S-(Benzo[d]thiazol-2-yl)-N-cyclohexylthiohydroxylamine, NCGC00159502-02, N-(1,3-benzothiazol-2-ylthio)cyclohexanamine, Conac H, DTXCID50360, N-Cyclohexyl-2-benzothiazolesulfenamide, N-[(1,3-Benzothiazol-2-yl)sulfanyl]cyclohexanamine, 2-Benzothiazolesulfenamide, N-cyclohexyl-, 95-33-0, 2-Benzothiazolesulfenamide, N-cyclohexyl-, 4-27-00-01867, 2-(Cyclohexylaminothio)benzothiazole, 2-Benzothiazolesulfenic acid N-cyclohexylamide, Accel CZ, Accelerator CZ, Accicure HBS, Banac CBS, BENZOTHIAZOLE-2-SULFENAMIDE, N-CYCLOHEXYL, Benzothiazyl-2-cyclohexylsulfenamide, Conac A, Conac S, CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE, Delac S, Ekagom CBS, N-ciclohexilbenzotiazol-2-sulfenamida, N-CYCLOHEXYL-2-BENZOTHIAZOLYL SULFENAMIDE, N-Cyclohexyl-2-benzothiazolylsulfenamide, N-Cyclohexyl-2-benzothiazolylsulphenamide, N-Cyclohexyl-2-benzothiazylsulfenamide, N-Cyclohexylbenzothiazol-2-sulfenamid, N-Cyclohexylbenzothiazole-2-sulfenamide, N-cyclohexylbenzothiazole-2-sulphenamide, N-Cyclohexylbenzothiazolesulfenamide, Nocceler CZ, Nocceler CZ-G, Nocceler CZ-P, NSC 4809, Pennac CBS, Rhenogran CBS, Rhodifax 16, Royal CBTS, Sanceler CM, Sanceler CM-G, Sanceler CM-PO, Sanceler CZ-P, Santocure, Santocure CBS, Soxinol CZ, Sulfenamide Ts, SULFENAMIDE, N-CYCLOHEXYL-2-BENZOTHIAZYL-, Sulfenax, Sulfenax CB, Sulfenax CB 30, Sulfenax CB/K, Thiohexam, Vulcafor CBS, Vulcafor HBS, Vulkacit C, Vulkacit CZ, Vulkacit CZ/C, Vulkacit CZ/CV, Vulkacit CZ/EG, Vulkacit CZ/EG-C, Vulkacit CZ/K, Vulkafil ZN 94TT02, 2-Benzenethiazolesulfenamide, N-cyclohexyl-, BRN 0192376, Conac H, Cyclohexyl benzothiazolesulfenamide, EINECS 202-411-2, Santocure Pellets, Santocure Powder, Santocure vulcanization accelerator, Sulfenax TsB, Vulkacite CZ, UNII-UCA53G94EV, 108251-59-8, 156014-54-9, 51540-81-9, 929698-33-9, Acelerator CZ, CBS, CBTS, Cyclohexylbenzothazyl Sulphenamide, Curax, Durax, N-Cyclohexyl-2-benzothiazyl Sulphenaminde, N-Cycloyhexylbenzothiazyl Sulphenamide, Santocure, Sulfenax CBS, Sulfenamide, N-Cyclohexyl-2-benzothiazolesulphenamide, N-Cyclohexyl-2-benzothiazyl sulfenamide, Thiohexam, N-Cyclohexyl-2-benzothiazylsulfenamide, N-Cyclohexyl-2-benzothiazolesulfenamide



N-Cyclohexyl-2-benzothiazole sulfenamide is a cross-linking agent that is used in the production of polymeric matrices.
N-Cyclohexyl-2-benzothiazole sulfenamide is a multi-walled carbon molecule with an aromatic hydrocarbon cross-linker.
N-Cyclohexyl-2-benzothiazole sulfenamide reacts with fatty acids to form cationic surfactants, which can be used as antimicrobial agents.


The reaction mechanism for this type of chemical reaction has been studied under constant pressure conditions and it was found that sulfur transfer occurs in the first step, followed by activation energies for the second and third steps.
The diameter of N-Cyclohexyl-2-benzothiazole sulfenamide depends on the degree of polymerization (DP).


N-Cyclohexyl-2-benzothiazole sulfenamide is a rubber accelerator chemical.
The most frequent occupational categories of N-Cyclohexyl-2-benzothiazole sulfenamide are metal industry, homemakers, health services and laboratories, and building industries.


N-Cyclohexyl-2-benzothiazole sulfenamide is a rubber cure accelerator.
N-Cyclohexyl-2-benzothiazole sulfenamide is also a known allergen and dermatological sensitizer.
Sensitivity to N-Cyclohexyl-2-benzothiazole sulfenamide may be identified with a clinical patch test.


N-Cyclohexyl-2-benzothiazole sulfenamide is a Standardized Chemical Allergen.
The physiologic effect of N-Cyclohexyl-2-benzothiazole sulfenamide is by means of Increased Histamine Release, and Cell-mediated Immunity.
N-Cyclohexyl-2-benzothiazole sulfenamide is a rubberaccelerator chemical.


The most frequent occupational categories of N-Cyclohexyl-2-benzothiazole sulfenamide are metal industry, homemakers, healthservices and laboratories, and building industries.
N-Cyclohexyl-2-benzothiazole sulfenamide is useful for the production of sulfur-modified chloroprene rubber.


N-Cyclohexyl-2-benzothiazole sulfenamide belongs to the class of organic compounds known as benzothiazoles.
These are organic compounds containing a benzene fused to a thiazole ring (a five-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).



USES and APPLICATIONS of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
N-Cyclohexyl-2-benzothiazole sulfenamide is a compound used in medium/fast curing of rubber, and is the most common sulfenamide accelerator.
N-Cyclohexyl-2-benzothiazole sulfenamide is used Accelerator in natural and styrene-butadienethiazyl sulfenamide, Adhesives and cements, Antifreeze, Condoms and diaphragms.


N-Cyclohexyl-2-benzothiazole sulfenamide is used feather shoes (insoles, adhesives, linings), Medical devices, Photographic film emulsion, and Rubber.
N-Cyclohexyl-2-benzothiazole sulfenamide is used rubber eyelash curlers, Rubber in elasticized under-garments and clothing, Rubber sheets and pillows, Shampoo, Soaps, and Sponge makeup applicators.


N-Cyclohexyl-2-benzothiazole sulfenamide is used veterinarian products like tick and flea powders and sprays.
N-Cyclohexyl-2-benzothiazole sulfenamide is used medium fast primary accelerator suitable for NR, IR, SBR, NBR, HR and EPDM. An
outstanding delayed action accelerator.


N-Cyclohexyl-2-benzothiazole sulfenamide is usually used alone, when activated by D, TT and TS.
N-Cyclohexyl-2-benzothiazole sulfenamide holds a prominent position in the realm of organic compounds, finding extensive utilization in rubber vulcanization and as an accelerator in the rubber industry.


Derived from benzothiazole, a heterocyclic aromatic compound, N-Cyclohexyl-2-benzothiazole sulfenamide manifests as a white, odorless crystalline powder.
The function of N-Cyclohexyl-2-benzothiazole sulfenamide lies in its ability to expedite the vulcanization process of rubber compounds.
N-Cyclohexyl-2-benzothiazole sulfenamide is used Culling oils, Detergents, Swimwear, Disinfectants, repellents, fungicides, Gloves, and Grease.


Acting as an activator, N-Cyclohexyl-2-benzothiazole sulfenamide accelerates the cross-linking of rubber molecules, leading to the production of a robust and enduring rubber product.
N-Cyclohexyl-2-benzothiazole sulfenamide is useful for the production of sulfur-modified chloroprene rubber.


N-Cyclohexyl-2-benzothiazole sulfenamide is used fine Chemicals.
Moreover, N-Cyclohexyl-2-benzothiazole sulfenamide heightens the reactivity between rubber molecules and sulfur, facilitating a more uniform and comprehensive vulcanization process.


N-Cyclohexyl-2-benzothiazole sulfenamide is a sulfenamide accelerator for use in the production of vulcanized rubbers, sealants and a wide range of other applications.
N-Cyclohexyl-2-benzothiazole sulfenamide is provided as a grey-white powder or granule and has a high curing rate with excellent scorching properties.


N-Cyclohexyl-2-benzothiazole sulfenamide is an excellent after-effect promoter, suitable for natural rubber and synthetic rubber, and can improve the physical and mechanical properties of rubber products.
N-Cyclohexyl-2-benzothiazole sulfenamide is used intermediate in organic synthesis.


N-Cyclohexyl-2-benzothiazole sulfenamide is used accelerator in natural and styrene-butadienethiazyl sulfenamide rubber.
N-Cyclohexyl-2-benzothiazole sulfenamide is an excellent after-effect promoter, suitable for natural rubber and synthetic rubber and rubber products such as tires.


-Rubber vulcanization accelerator CZ, the scientific name N-Cyclohexyl-2-benzothiazole sulfenamide, is a highly active after-effect semi-overspeed accelerator, excellent coke resistance, processing safety, short vulcanization time.
N-Cyclohexyl-2-benzothiazole sulfenamide can be used as vulcanization accelerator alone or in combination with other accelerators such as D, DT, TT and TS.
N-Cyclohexyl-2-benzothiazole sulfenamide is used for the preparation of tires, rubber belts, cables, rubber pipes and other general industrial supplies.


-N-Cyclohexyl-2-benzothiazole sulfenamide is one of the commonly used aftereffect promoters.
N-Cyclohexyl-2-benzothiazole sulfenamide is suitable for the use of black rubber.
N-Cyclohexyl-2-benzothiazole sulfenamide is mainly used for tires, rubber shoes, rubber hose, tape, cable, general industrial products.


-N-Cyclohexyl-2-benzothiazole sulfenamide is a highly active aftereffect accelerator with excellent scorch resistance, safe processing and short vulcanization time.
N-Cyclohexyl-2-benzothiazole sulfenamide is often used with TMTD or other alkaline accelerators such as Tyuram and dithiocarbamates to increase its activity.
N-Cyclohexyl-2-benzothiazole sulfenamide is mainly used in the manufacture of tires, hoses, shoes, cables and other industrial rubber products.



PROPERTIES OF N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
N-Cyclohexyl-2-benzothiazole sulfenamide is a slight odor.
N-Cyclohexyl-2-benzothiazole sulfenamide is soluble in benzene, chloroform, carbon disulfide; Insoluble in water.



ALTERNATIVE PARENTSN OF N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
*Benzenoids
*Thiazoles
*Heteroaromatic compounds
*Sulfenyl compounds
*Organosulfenic acid amides
*Azacyclic compounds
*Organopnictogen compounds
*Organonitrogen compounds
*Hydrocarbon derivatives



SUBSTITUENTS OF N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
*1,3-benzothiazole
*Benzenoid
*Heteroaromatic compound
*Thiazole
*Azole
*Azacycle
*Sulfenyl compound
*Organosulfenic acid amide
*Organic nitrogen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organosulfur compound
*Organonitrogen compound
*Aromatic heteropolycyclic compound



WHERE IS N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE FOUND?
N-Cyclohexyl-2-benzothiazole sulfenamide is a rubber accelerator.
N-Cyclohexyl-2-benzothiazole sulfenamide is found in the rubber industry.



N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE SALES MARKET INTRODUCTION
From 2023 to 2031, the N-cyclohexyl -2- Benzothiazole Sulfenamide (CBS) Sales Market undergoes a meticulous evaluation during the forecasted period.
This assessment intricately explores diverse segments, dissecting prevailing trends and essential factors shaping the market's trajectory.
A comprehensive analysis of market dynamics, encompassing drivers, restraints, opportunities, and challenges, is undertaken to elucidate their cumulative effect on market dynamics.

This examination takes into consideration both intrinsic elements like drivers and restraints and external factors like market opportunities and challenges.
The current market study of N-Cyclohexyl-2-benzothiazole sulfenamide provides an outlook on the development of market in terms of revenue throughout the prognosis period.

The N-Cyclohexyl-2-benzothiazole sulfenamide Sales Market has encountered rapid and substantial growth in recent years, and projections indicate a continued significant expansion from 2023 to 2031.
The upward trend observed in market dynamics, coupled with the expected sustained expansion, suggests robust growth rates during the forecasted period.

In summary, the market is on the brink of significant and noteworthy development.
In recent years, the N-cyclohexyl -2- Benzothiazole Sulfenamide (CBS) Sales Market has undergone a swift and substantial surge, and the projections for sustained significant expansion from 2023 to 2031 signify a persistent upward trend in market dynamics, indicating strong growth rates in the foreseeable future.



PHYSICAL and CHEMICAL PROPERTIES of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
CAS Number: 95-33-0
Purity: 99%
MDL Number: MFCD00022872
Molecular Formula: C13H16N2S2
Molecular Weight: 264.41 g/mol
Melting Point: 93-100°C
Boiling Point: 410.4°C
Flash Point: 202°C
EINECS Number: 202-411-2
Density: 1.31-1.34 g/cm3
Appearance: White to light gray and red-gray to brown crystals or powder
Drying Loss: 0.40% Max
Ash: 0.40% Max

Solubility: Soluble in benzene, ethanol, and acetone. Insoluble in water.
pKa: 0.59±0.10 (Predicted)
Vapor Pressure: 6.04E-07 mmHg at 25°C
Refractive Index: n20D ~1.67 (Predicted)
Storage Condition: Keep in a dark place, sealed in dry, at room temperature
InChI: InChI=1/C13H16N2S2/c1-2-6-10(7-3-1)15-17-13-14-11-8-4-5-9-12(11)16-13/h4-5,8-10,15H,1-3,6-7H2
InChI Key: DEQZTKGFXNUBJL-UHFFFAOYSA-N
Molecular Formula: C13H16N2S2
Molecular Weight: 296.408 g/mol
XLogP3-AA: 4.4
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 3

Exact Mass: 264.07549087 g/mol
Monoisotopic Mass: 264.07549087 g/mol
Topological Polar Surface Area: 78.5 Ų
Heavy Atom Count: 17
Formal Charge: 0
Complexity: 244
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1

Compound Is Canonicalized: Yes
Chemical Information:
CAS Number: 95-33-0
Other Names: N-Cyclohexyl-2-benzothiazole sulfonamide
EINECS Number: 202-411-2
Purity: 99.7%
Type: Sulfenamides Rubber Accelerator
Physical Properties:
Physical State (20°C): Solid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
Identification and References:
Reaxys Registry Number: 192376
PubChem Substance ID: 87565678

MDL Number: MFCD00022872
Appearance: Pale yellow to light beige powder
Physical State: Solid
Solubility: Soluble in benzene, ethanol, and acetone; insoluble in water
Storage: Keep in a dark place, sealed in dry conditions, at room temperature
Melting Point: 93-100 °C (94-102 °C in another source)
Boiling Point: 410.4 °C at 760 mmHg
Density: 1.26 g/cm³ (Specific Gravity: 1.29 in another source)
Refractive Index: n20D ~1.67 (Predicted), 1.5700 (estimate in another source)
CAS Registry Number: 95-33-0
Molecular Formula: C13H16N2S2

Molecular Weight: 264.41 g/mol (264.415 g/mol in another source)
MDL Number: MFCD00022872
CBNumber: CB9360750
EINECS Number: 202-411-2
InChI: InChI=1S/C13H16N2S2/c1-2-6-10(7-3-1)15-17-13-14-11-8-4-5-9-12(11)16-13/h4-5,8-10,15H,1-3,6-7H2
InChIKey: DEQZTKGFXNUBJL-UHFFFAOYSA-N
PSA: 78.46000 Ų
LogP: 4.61660
Flash Point: 202 °C
Transport Information: UN 3077
Classification: Compounds containing sulfur; ureas, amides, cyanurates
Content: Ash Content= 0.50%, Moisture Content= 9.50%



FIRST AID MEASURES of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.



FIRE FIGHTING MEASURES of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available



EXPOSURE CONTROLS/PERSONAL PROTECTION of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.



STABILITY and REACTIVITY of N-CYCLOHEXYL-2-BENZOTHIAZOLE SULFENAMIDE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a crystalline compound with a pale yellow to light brown color.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is classified as an accelerator used in the vulcanization process of rubber.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) plays a crucial role in improving the mechanical properties of rubber products.

CAS Number: 95-33-0
EC Number: 202-411-2

Synonyms: CBTS, N-Cyclohexyl-2-benzothiazolylsulfenamide, N-Cyclohexyl-2-benzothiazole sulfenamide, CBS, N-Cyclohexyl-2-benzothiazolethione, 2-(Cyclohexylaminothio)benzothiazole, Benzothiazyl-2-cyclohexylsulfenamide, N-Cyclohexylbenzothiazole-2-sulfenamide, Accicure HBS, Accitard, Altax, Conacure CBS, Cusal C, Cyclohexyl-2-benzothiazolesulfenamide, Cyclicthiozylsulfenamide, Delac NS, Delac NS (accelerator), Ekagom CBS, Haltocur CBS, Naugex CBS, Naugex CBS (accelerator), Nocceler CZ, Nocceler CZ (vulcanization accelerator), Pennac CBS, Perkacit CBS, Perkacit CZ, Rhenogran CBS, Royal CBTS, Santocure CBS, Sancure CBS, Sirantox CZ, Thiazone C, Thiazone C (accelerator), TMTM-CBS, Tetrone A, Usaflex CZ, Usaflex CZ (accelerator), Vulkacit CZ, Vulkacit CZ (accelerator), Vulkacit NZ, Vulkafor CZ, Vulkalent CZ, Vulkalent NZ, Vulkazon CBS, Vulkazon CZ, Vulkazon NS, Vulkazit CZ, Vulkazit CZ (accelerator), Accel CBS, Accel CBS (accelerator), Aceto CT, Aceto CZ, Altax CBS, Benzothiazyl-2-cyclohexylsulfenamide, CBS (accelerator), CBS (vulcanization accelerator), Conacure CBS (accelerator), Delac NS (accelerator), Delac NS, Ekagom CBS



APPLICATIONS


N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is primarily used as an accelerator in the vulcanization process of rubber.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the curing of rubber compounds by promoting the formation of cross-links between polymer chains.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is crucial in the production of automotive tires to enhance their durability and performance.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the manufacturing of conveyor belts to improve resilience and wear resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in rubber seals and gaskets to ensure tight seals and longevity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in industrial rubber products such as hoses and seals to enhance their mechanical properties.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the vulcanization of rubber latex used in glove manufacturing, improving strength and elasticity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is incorporated into shoe soles to increase their abrasion resistance and durability.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber mats and flooring materials for its impact resistance and longevity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber sheeting used in construction and industrial applications for improved performance under harsh conditions.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in molded rubber parts for machinery and equipment to enhance their reliability and longevity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) plays a role in the production of rubber insulation materials for electrical cables and components.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the manufacturing of rubber seals and O-rings for mechanical and automotive applications.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber compounds used in vibration isolators and dampeners to improve their damping properties.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the production of rubber rollers used in printing and manufacturing processes for their durability and resistance to wear.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber conveyor belts used in mining and industrial operations for their strength and longevity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the curing of rubber used in marine fenders and bumpers for ships and docks.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the production of agricultural rubber products such as belts and hoses for their resilience and resistance to agricultural chemicals.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber components used in aerospace applications for their reliability and resistance to extreme temperatures and conditions.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of sports equipment such as balls and mats for its impact resistance and durability.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the manufacturing of rubber coatings and linings for tanks and containers to prevent corrosion and leakage.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber components used in medical devices and equipment for its biocompatibility and durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the vulcanization of rubber used in automotive suspension systems for improved performance and safety.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber seals and gaskets for food processing equipment for its compliance with food safety standards.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is essential in various other industrial applications where rubber products require enhanced strength, durability, and performance.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of automotive rubber components such as engine mounts and suspension bushings for improved vibration damping and durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber compounds used in the construction of railroad ties and track pads to enhance their resilience and longevity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the production of rubber diaphragms and membranes used in pumps and valves for its flexibility and resistance to chemical exposure.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the formulation of rubber conveyor belts used in food processing industries for their hygienic properties and durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the curing of rubber used in the manufacturing of inflatable products such as balloons and air mattresses for their strength and elasticity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is incorporated into rubber hoses and tubing used in industrial and automotive applications for their flexibility and resistance to abrasion.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the production of rubber linings and coatings for tanks and pipelines in chemical processing plants for corrosion protection.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber components used in the construction of bridges and infrastructure for their resistance to weathering and environmental conditions.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the vulcanization of rubber used in the production of footwear such as boots and shoes for their durability and comfort.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the formulation of rubber seals and gaskets used in HVAC systems and mechanical equipment for their sealing properties and longevity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the production of rubber parts for bicycles and motorcycles, including tires and inner tubes, for their reliability and performance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the manufacturing of rubber dampers and isolators used in building construction and machinery for vibration control.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the curing of rubber used in the production of marine equipment such as boat fenders and dock bumpers for their impact resistance.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS)is added to rubber components used in the production of household appliances such as washing machine seals and refrigerator gaskets for their durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the formulation of rubber flooring and mats used in gyms and recreational facilities for their shock absorption and slip resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the production of rubber gloves and protective clothing for industrial workers and healthcare professionals for its barrier properties.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the manufacturing of rubberized fabrics and textiles for applications such as rainwear, tents, and industrial covers for their weather resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the vulcanization of rubber used in the production of automotive belts and hoses for their resistance to heat and chemical exposure.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber components used in mining equipment such as conveyor belts and hoses for their strength and abrasion resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the formulation of rubber seals and gaskets used in aerospace applications for their reliability under extreme temperature and pressure conditions.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber components for electrical insulation, including cables and wiring harnesses, for their dielectric properties.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the curing of rubber used in the production of pneumatic and hydraulic seals for machinery and equipment for their sealing effectiveness.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the formulation of rubber components used in the construction of amusement park rides and equipment for their safety and durability.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is added to rubber compounds used in the production of sporting goods such as balls, grips, and padding for their performance and longevity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in various niche applications where rubber products require specific performance enhancements, such as in military equipment and specialized industrial machinery.

CBTS accelerates the formation of cross-links between polymer chains, crucial for rubber hardness.
Manufacturers rely on CBTS to achieve consistent quality and performance in rubber products.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) contributes to reducing the curing time of rubber compounds, enhancing productivity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) formulations are tailored to meet specific requirements for different types of rubber applications.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) undergoes chemical reactions during vulcanization that lead to the formation of resilient rubber networks.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is carefully regulated in industrial settings to minimize environmental and health risks.

Rubber compounds containing CBTS exhibit excellent aging properties, prolonging product lifespan.
The chemical properties of CBTS make it suitable for use in both natural and synthetic rubber formulations.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a key ingredient in rubber compounding, valued for its role in enhancing overall performance and durability.



DESCRIPTION


N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a crystalline compound with a pale yellow to light brown color.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is classified as an accelerator used in the vulcanization process of rubber.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) plays a crucial role in improving the mechanical properties of rubber products.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) accelerates the cross-linking of rubber molecules, enhancing elasticity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is sparingly soluble in water but dissolves readily in organic solvents.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) has a characteristic odor and is commonly used in rubber compounding.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) facilitates faster curing times in rubber production, optimizing manufacturing processes.
The chemical structure of CBTS includes a benzothiazole ring with a cyclohexylamine group.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is known by various trade names in the rubber industry, reflecting its versatility and importance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) acts as a sulfur donor during vulcanization, contributing to improved heat resistance of rubber.

The use of CBTS in rubber formulations results in products with enhanced durability and resilience.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is effective in promoting the dispersion of fillers and reinforcing agents in rubber compounds.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) exhibits moderate toxicity and requires careful handling and storage practices.
Rubber products incorporating CBTS show increased tensile strength and tear resistance.

The chemical stability of CBTS ensures its effectiveness over a wide range of temperatures.
It is an essential component in the production of automotive tires and industrial rubber goods.



PROPERTIES


Physical Properties:

Appearance: Pale yellow to light brown crystalline powder
Odor: Slight characteristic odor
Melting Point: Approximately 98-104°C
Boiling Point: Decomposes before boiling
Density: Approximately 1.31 g/cm³
Solubility in Water: Sparingly soluble
Solubility in Solvents: Soluble in organic solvents such as acetone, benzene, ethanol
Vapor Pressure: Not applicable (low volatility)
Particle Size: Typically in the micron range (specific size may vary depending on manufacturing process)
Flash Point: Not applicable (non-flammable)
Autoignition Temperature: Not determined


Chemical Properties:

Chemical Formula: C₁₃H₁₆N₂S₂
Molecular Weight: 264.41 g/mol
Structure: Benzothiazole ring with a cyclohexylamine group attached to the sulfur atom
Acidity/Basicity: Neutral compound
Purity: Typically high purity for industrial applications
Hygroscopicity: Low moisture absorption
Stability: Stable under normal storage conditions
Reactivity: Reacts with accelerators and sulfur during rubber vulcanization
Compatibility: Compatible with other rubber chemicals and processing aids
Photostability: Stable under normal light conditions
Oxidative Stability: Stable, but may degrade in the presence of strong oxidizing agents
Flammability: Non-flammable



FIRST AID


Inhalation:

Move to Fresh Air:
If CBTS dust or vapors are inhaled, immediately move the affected person to fresh air.

Provide Oxygen:
If breathing is difficult, provide oxygen support if trained personnel are available.

Seek Medical Attention:
Even if symptoms are mild or absent, seek medical evaluation as CBTS inhalation can irritate the respiratory tract.


Skin Contact:

Remove Contaminated Clothing:
Quickly remove any contaminated clothing and footwear.

Wash Skin:
Wash the affected skin area thoroughly with soap and water for at least 15 minutes to remove any CBTS.

Seek Medical Advice:
If irritation, redness, or rash develops, seek medical attention promptly.

Apply Moisturizer:
After washing, apply a soothing moisturizer to the affected area to alleviate discomfort.


Eye Contact:

Flush with Water:
Immediately flush the eyes with gently flowing lukewarm water for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.

Remove Contact Lenses:
If present and easily removable, remove contact lenses after the initial flush.

Seek Medical Attention:
Even if there are no immediate symptoms, seek medical evaluation to ensure no eye damage has occurred.


Ingestion:

Do Not Induce Vomiting:
Do not induce vomiting unless instructed to do so by medical personnel.

Rinse Mouth:
If CBTS is swallowed and the person is conscious, rinse their mouth thoroughly with water.

Drink Water:
Have the person drink plenty of water to dilute any swallowed CBTS.

Seek Medical Attention:
Seek immediate medical attention or contact a poison control center for further guidance.



HANDLING AND STORAGE


Handling of CBTS:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including safety goggles or face shield to protect eyes from dust, and gloves to prevent skin contact.
Use a dust mask or respirator if handling CBTS in powdered form to avoid inhalation of dust particles.

Handling Practices:
Avoid generating dust: Handle CBTS in a manner that minimizes dust formation (e.g., use of closed systems, local exhaust ventilation).
Use tools and equipment designed for handling powders to minimize spills and airborne particles.

Hygiene Practices:
Wash hands thoroughly with soap and water after handling CBTS, especially before eating, drinking, or using the restroom.
Avoid touching face, eyes, and mouth while working with CBTS to prevent accidental ingestion or irritation.

Compatibility:
Store and handle CBTS away from incompatible materials, including strong oxidizing agents, acids, and alkalis.
Ensure containers are properly labeled and segregated to prevent cross-contamination.

Static Electricity:
CBTS powders can generate static electricity. Use grounded equipment and containers to minimize the risk of static discharge.

Spills and Cleanup:
Clean up spills immediately using methods that minimize dust generation (e.g., damp cloth, vacuum cleaner equipped with HEPA filter).
Dispose of spilled material according to local regulations and safety procedures.

Storage of Empty Containers:
Empty containers may retain residue.
Handle empty containers with care and follow appropriate cleaning and disposal procedures.


Storage of CBTS:

Storage Conditions:
Store CBTS in tightly sealed containers to prevent contamination and exposure to moisture.
Maintain storage temperatures between 15°C to 25°C (59°F to 77°F) to avoid degradation.
Protect from direct sunlight and sources of heat to maintain product stability.

Container Requirements:
Use containers made of materials compatible with CBTS (e.g., high-density polyethylene, glass).
Ensure containers are labeled with appropriate hazard symbols, product information, and handling instructions.

Ventilation:
Provide adequate ventilation in storage areas to disperse any airborne dust and maintain air quality.

Separation:
Store CBTS away from food, beverages, and animal feed to prevent accidental contamination.

Inventory Control:
Implement a first-in, first-out (FIFO) inventory system to ensure older stock is used first, minimizing storage time and potential degradation.

Security:
Restrict access to storage areas to authorized personnel only.
Store CBTS in a secure location to prevent unauthorized handling or theft.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a high-performance rubber accelerator widely used in the rubber industry to improve the vulcanization process.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is known for its ability to enhance the physical properties of rubber products, including elasticity and durability.
The chemical formula for N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is C13H16N2S2, and it is commonly used in various industrial applications due to its effective properties.

CAS Number: 95-33-0
EC Number: 202-411-2

Synonyms: N-Cyclohexylbenzothiazole-2-sulfenamide, CBTS, N-Cyclohexyl-2-benzothiazole sulfenamide, CBS, Santocure CBS, Accelerator CBS, 2-Benzothiazolesulfenamide, N-Cyclohexylbenzothiazole sulfenamide, N-Cyclohexylbenzothiazol-2-ylsulfenamide, Vulcanization accelerator CBS, N-Cyclohexyl-2-thiobenzothiazole sulfenamide, Cyclohexylbenzothiazole sulfenamide, CBS Accelerator, 2-Benzothiazolesulfenamide, N-cyclohexyl-, Cyclohexylbenzothiazol-2-ylsulfenamide



APPLICATIONS


N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is extensively used as a primary accelerator in the vulcanization of natural and synthetic rubbers.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a preferred choice in the production of tires, providing excellent scorch safety and fast curing.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the manufacturing of industrial rubber products, including hoses, belts, and seals, enhancing their durability.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is widely used in the production of automotive rubber components, such as gaskets and weatherstrips, ensuring optimal performance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the formulation of rubber compounds for footwear, providing superior flexibility and wear resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the rubber industry for the production of conveyor belts, enhancing their strength and longevity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the production of rubberized fabrics, improving their elasticity and durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a key component in the manufacturing of rubber-based adhesives and sealants, providing enhanced bonding strength.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the formulation of specialty rubber compounds for industrial applications, ensuring consistent quality and performance.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the creation of high-performance rubber products for the construction industry, including rubber mats and protective coatings.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber sheets and films, enhancing their flexibility and tensile strength.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the manufacturing of rubber insulation materials, providing improved thermal stability and resistance to aging.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is found in the production of rubber seals and O-rings, ensuring their long-term performance and resistance to environmental factors.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the automotive industry for the production of high-performance rubber hoses, contributing to their durability and heat resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the formulation of rubber compounds for vibration dampening products, providing excellent shock absorption.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the production of specialty rubber compounds used in the aerospace industry, enhancing their performance under extreme conditions.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the manufacturing of rubber components for marine applications, ensuring their resistance to saltwater and UV exposure.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is found in the production of rubber grommets and bushings, providing improved elasticity and wear resistance.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the creation of rubber linings for industrial equipment, enhancing their resistance to abrasion and chemicals.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber components for mining applications, providing superior durability and impact resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the formulation of rubber compounds for high-pressure hydraulic seals, ensuring their long-term performance.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber profiles for construction joints, providing enhanced sealing properties and durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the manufacturing of rubber components for railways, contributing to their resistance to wear and environmental factors.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the production of rubber components for oil and gas exploration, ensuring their performance under high-pressure conditions.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is found in the formulation of rubber compounds for industrial rollers, providing improved wear resistance and load-bearing capacity.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the creation of specialty rubber compounds for high-temperature applications, ensuring their stability and performance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a key component in the production of rubber components for heavy machinery, enhancing their durability and resistance to harsh environments.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the production of rubber components for industrial valves, providing improved sealing properties and chemical resistance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the formulation of rubber compounds for electrical insulation, ensuring their long-term stability and performance.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the production of rubber belts and drive systems, enhancing their flexibility and load-bearing capacity.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is found in the manufacturing of rubber components for the food and beverage industry, ensuring their compliance with safety standards.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the formulation of rubber compounds for medical applications, providing biocompatibility and durability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is employed in the creation of rubber linings for storage tanks, ensuring their resistance to chemical corrosion.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is utilized in the production of rubber components for agricultural machinery, enhancing their durability and performance in demanding conditions.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is used in the formulation of rubber compounds for high-performance automotive parts, providing enhanced resistance to heat and wear.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a key ingredient in the production of rubber components for the electronics industry, ensuring their long-term stability and performance.



DESCRIPTION


N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a high-performance rubber accelerator widely used in the rubber industry to improve the vulcanization process.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is known for its ability to enhance the physical properties of rubber products, including elasticity and durability.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a versatile chemical compound used in various rubber applications.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) provides excellent scorch safety, allowing for extended processing times without compromising the quality of the final product.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is essential in the production of high-performance rubber products, contributing to their strength and resistance to wear.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is widely used in the automotive industry, where it enhances the performance and durability of rubber components.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is also employed in the manufacturing of industrial rubber products, including hoses, seals, and gaskets, ensuring their long-term reliability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a critical accelerator in the vulcanization process, providing optimal curing and improving the overall quality of rubber compounds.

N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is recognized for its stability and effectiveness in a wide range of rubber applications, from automotive components to industrial products.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is essential in the formulation of specialty rubber compounds, providing consistent performance and reliability.
N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is a key ingredient in the production of rubber materials used in demanding environments, ensuring their resistance to extreme conditions.



PROPERTIES


Chemical Formula: C13H16N2S2
Common Name: N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS)
Molecular Structure:
Appearance: Off-white to pale yellow powder
Density: 1.26 g/cm³
Melting Point: 96-104°C
Solubility: Insoluble in water; soluble in benzene, acetone, and chloroform
Flash Point: 233°C
Reactivity: Stable under normal conditions; decomposes at high temperatures
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store below 25°C in a dry, well-ventilated area
Vapor Pressure: Negligible at room temperature



FIRST AID


Inhalation:
If N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Remove contaminated clothing and footwear.
Wash the affected skin area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Launder contaminated clothing before reuse.

Eye Contact:
Flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
Do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.



HANDLING AND STORAGE


Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles or face shield, and protective clothing.
Use respiratory protection if ventilation is insufficient or if exposure limits are exceeded.

Ventilation:
Ensure adequate ventilation in the working area to control airborne concentrations below occupational exposure limits.
Use local exhaust ventilation or other engineering controls to minimize exposure.

Avoidance:
Avoid direct skin contact and inhalation of dust or vapors.
Do not eat, drink, or smoke while handling N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS).
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Use appropriate personal protective equipment.
Contain spills to prevent further release and minimize exposure.
Avoid generating dust. Sweep up and collect the material for disposal in a sealed container.

Storage:
Store N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) in a cool, dry, well-ventilated area away from incompatible materials (see SDS for specific details).
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and ignition sources.

Handling Cautions:
Avoid generating dust or aerosols.
Ground and bond containers during transfer operations to prevent static electricity buildup.
Use explosion-proof electrical equipment in areas where dust or vapors may be present.


Storage:

Temperature:
Store N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) at temperatures recommended by the manufacturer.
Avoid exposure to extreme temperatures.

Containers:
Use approved containers made of compatible materials.
Check for leaks or damage in storage containers regularly.

Separation:
Store N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) away from incompatible materials, including strong acids, bases, and oxidizing agents.

Handling Equipment:
Use dedicated equipment for handling N-Cyclohexyl-2-benzothiazolesulfenamide (CBTS) to avoid cross-contamination.
Ensure all handling equipment is in good condition.

Security Measures:
Restrict access to storage areas.
Follow all applicable local regulations regarding the storage of hazardous materials.

Emergency Response:
Have emergency response equipment and materials readily available, including spill cleanup materials, fire extinguishers, and emergency eyewash stations.

DESCRIPTION:
N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS) is a rubber cure accelerator.
N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS) is also a known allergen and dermatological sensitizer.
Sensitivity to N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS) may be identified with a clinical patch test.

CAS: 95-33-0
European Community (EC) Number: 202-411-2
IUPAC Name: N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
Molecular Formula: C13H16N2S2


SYNONYMS OF N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS):
N-cyclohexyl-2-benzothiazolesulfenamide, N-cyclohexyl-2-benzothiazyl sulfenamide,N-cyclohexyl-2-benzothiazylsulfenamide,thiohexam,95-33-0,N-Cyclohexyl-2-benzothiazolesulfenamide,Thiohexam,Sulfenax,N-Cyclohexyl-2-benzothiazolylsulfenamide,Accelerator CZ,Vulkacit CZ,Santocure,Curax,Durax,Sulfenamide Ts,Santocure Powder,Sulfenax TsB,Vulkacite CZ,Sulfenax CB,Santocure Pellets,Vulcafor CBS,Conac A,Conac S,Delac S,Ekagom CBS,Royal CBTS,Rhodifax 16,Sulfenax CB 30,Vulcafor hbs,Soxinol cz,Vulkacit c,Sulfenax cb/k,Vulkacit cz/c,Vulkacit cz/k,Nocceler CZ,Accicure HBS,N-Cyclohexyl-2-benzothiazylsulfenamide,Pennac CBS,Sanceler CM-PO,2-(Cyclohexylaminothio)benzothiazole,2,Benzothiazolesulfenamide, N-cyclohexyl-,Benzothiazyl-2-cyclohexylsulfenamide,N-Cyclohexylbenzothiazole-2-sulfenamide,N-Cyclohexyl-2-benzothiazosulfenamide,N-Cyclohexyl-2-benzothiazole sulfenamide,Cyclohexyl benzothiazolesulfenamide,N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine,Santocure vulcanization accelerator,CBTS,N-Cyclohexylbenzothiazole-2-sulphenamide,2-Benzenethiazolesulfenamide, N-cyclohexyl-,UCA53G94EV,DTXSID5020360,NSC-4809,S-(Benzo[d]thiazol-2-yl)-N-cyclohexylthiohydroxylamine,NCGC00159502-02,N-(1,3-benzothiazol-2-ylthio)cyclohexanamine,Conac H,DTXCID50360,NSC 4809; Nocceler CZ; Accelerator CZ; Accicure HBS,Sufenax cb,CAS-95-33-0,SMR001798878,CCRIS 4910,HSDB 2868,NSC 4809,EINECS 202-411-2,UNII-UCA53G94EV,BRN 0192376,AI3-16782,Vulkacit cz/eg,Perkacit CBS,Akrochem CBTS,Ekaland CBS,Sanceler CM-G,Banac CBS,Vulkacit CZ/EG-C,CBS, N-Cyclohexyl-2-benzothiazolesulfenamide,EC 202-411-2,SCHEMBL80270,4-27-00-01867 (Beilstein Handbook Reference),MLS004773968,MLS006010082,CHEMBL1591074,DEQZTKGFXNUBJL-UHFFFAOYSA-,NSC4809,Cyclohexylbenzothiazyl sulphenamide,Cyclohexylbenzothiazolylsulphenamide,Cyclohexyl benzothiazole sulfenamide,N-Cyclohexylbenzothiazoylsulfenamide,N-Cyclohexylbenzothiazyl sulphenamide,Tox21_111721,Tox21_202436,Tox21_302924,MFCD00022872,AKOS003658709,N-Cyclohexyl-2-benzthiazyl sulfenamide,N-Cyclohexyl-2-benzthiazyl sulfonamide,DB14200,HY-W020755,WLN: T56 BN DSJ CSM- AL6TJ,N-Cyclohexyl-2-benzothiazolylsulfonamide,N-Cyclohexyl-2-benzothiazyl sulphenamide,NCGC00159502-03,NCGC00159502-04,NCGC00256366-01,NCGC00259985-01,AS-15575,N-CYCLOHEXYLBENZOTHIAZYL-SULPHENAMIDE,CS-0040170,FT-0631486,E80913,EN300-7402242,2-(CYCLOHEXYLAMINOTHIO)BENZOTHIAZOLE [HSDB],Q4445828,W-100165,BRD-K64191834-001-03-1,S-(1,3-Benzothiazol-2-yl)-N-cyclohexylthiohydroxylamine,S-(1,3-Benzothiazol-2-yl)-N-cyclohexylthiohydroxylamine #,[(3aS,4R,9S,10aS)-2-amino-5,10,10-trihydroxy-6-imino-9-sulfooxy-3a,4,8,9-tetrahydro-1H-pyrrolo[1,2-c]purin-4-yl]methoxycarbonylsulfamic acid,InChI=1/C13H16N2S2/c1-2-6-10(7-3-1)15-17-13-14-11-8-4-5-9-12(11)16-13/h4-5,8-10,15H,1-3,6-7H2, N,N'-bis-(1,4-dimethyl-pentyl)-p-phenylenediamine; N-Cyclohexylbenzothiazyl sulfenamide; CBTS, CBS; Cyclohexylbenzothiazyl sulfenamide; N-Cyclohexyl-2-benzothiazyl sulfenamide; Santocure; N,N'-bis(1,4-dimethylpentyl) 1,4-benzenediamine; N,N-di(1,4-dimethylpentyl)-p-phenylenediamine; eastozone 33; eastozone; tenamene; santoflex 77; Vulkanox 4030, 2-(Cyclohexylaminothio)benzothiazole;Accelerator CZ;AccicureHBS;Banac CBS;Benzothiazyl-2-cyclohexylsulfenamide;CBS;CBS (accelerator);CBTS;Conac A;Conac S;Delac S;Ekagom CBS;N-Cyclohexyl-2-benzothiazolesulfenamide;N-Cyclohexyl-2-benzothiazolylsulphenamide;N-Cyclohexyl-2-benzothiazylsulfenamide;N-Cyclohexylbenzothiazole-2-sulphenamide;NSC 4809;Nocceler CZ-G;Nocceler CZ-P;Pennac CBS;Rhodifax 16;Accel CZ;2-Benzothiazolesulfenic acid N-cyclohexylamide;Sanceler CM;Royal CBTS;Sanceler CM-G;Santocure;Santocure CBS;Sulfenamide Ts;Sulfenax;SulfenaxCB;Sulfenax CB 30;Vulkacit C;Vulkacit CZ/C;Vulkacit CZ/EG;Vulkacit CZ/EG-C;


N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS) is a Standardized Chemical Allergen.
The physiologic effect of N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS) is by means of Increased Histamine Release, and Cell-mediated Immunity.

This is a chemical used as a rubber accelerator and can be found in rubber products.
Further research may identify additional product or industrial usages of N-cyclohexyl-2-benzothiazosulfenamide (CBTS).


N-cyclohexyl-2-benzothiazosulfenamide (CBTS) holds a prominent position in the realm of organic compounds, finding extensive utilization in rubber vulcanization and as an accelerator in the rubber industry.
Derived from benzothiazole, a heterocyclic aromatic compound, N-cyclohexyl-2-benzothiazosulfenamide (CBTS) manifests as a white, odorless crystalline powder.
The function of N-cyclohexyl-2-benzothiazosulfenamide (CBTS) lies in its ability to expedite the vulcanization process of rubber compounds.
Acting as an activator, N-cyclohexyl-2-benzothiazosulfenamide (CBTS) accelerates the cross-linking of rubber molecules, leading to the production of a robust and enduring rubber product.
Moreover, N-cyclohexyl-2-benzothiazosulfenamide (CBTS) heightens the reactivity between rubber molecules and sulfur, facilitating a more uniform and comprehensive vulcanization process.



USES OF N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS):
N-cyclohexyl-2-benzothiazosulfenamide (CBTS) is used as Intermediate in organic synthesis.
N-cyclohexyl-2-benzothiazosulfenamide (CBTS) is used as Accelerator in natural and styrene-butadienethiazyl sulfenamide rubber.
N-Cyclohexylbenzo[d]thiazole-2-sulfonamide is useful for the production of sulfur-modified chloroprene rubber.

N-Cyclohexyl-2-benzothiazole sulfenamide CBS (CZ) is a sulfenamide accelerator for use in the production of vulcanized rubbers, sealants and a wide range of other applications.
N-Cyclohexyl-2-benzothiazole sulfenamide is provided as a grey-white powder or granule and has a high curing rate with excellent scorching properties.



METHODS OF MANUFACTURING OF N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS):
N-cyclohexyl-2-benzothiazosulfenamide (CBTS) is derived from the reaction of accelerator M (2-thiol benzothiazole) with cyclohexylamin added dropwise under stirring to obtain a crude product.
The solid material is separated, washed with water to neutrality, and dried below 75°C to obtain a finished product.
Raw material consumption (kg/t) accelerator M (95%) 745 cyclohexylamine (95%) 500




SAFETY INFORMATION ABOUT N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS):

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product






CHEMICAL AND PHYSICAL PROPERTIES OF N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE (CBTS):
Molecular Weight
264.4 g/mol
XLogP3-AA
4.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
264.07549087 g/mol
Monoisotopic Mass
264.07549087 g/mol
Topological Polar Surface Area
78.5Ų
Heavy Atom Count
17
Formal Charge
0
Complexity
244
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Molecular FormulaC13H16N2S2
Average mass264.409 Da
Monoisotopic mass264.075500 Da
ChemSpider ID6962
Melting point, 93-100°C
Boiling point, 410.4±28.0 °C(Predicted)
Density, 1.31~1.34g/cm3
vapor pressure, 0Pa at 25℃
refractive index, 1.5700 (estimate)
storage temp., Keep in dark place,Sealed in dry,Room Temperature
solubility, Chloroform (Slightly), DMSO (Slightly), Ethyl Acetatae (Slightly)
form, Solid
pka, 0.59±0.10(Predicted)
color, Pale Yellow to Light Beige
Water Solubility, Insoluble
InChIKey, DEQZTKGFXNUBJL-UHFFFAOYSA-N
LogP, 5 at 25℃
Name, N-Cyclohexyl-2-benzothiazolesulfenamide, EINECS, 202-411-2
CAS No., 95-33-0, Density, 1.26 g/cm3
PSA, 78.46000, LogP, 4.61660
Solubility, Insoluble in water, Melting Point, 93-100 °C
Formula, C13H16N2S2, Boiling Point, 410.4 °C at 760 mmHg
Molecular Weight, 264.415, Flash Point, 202 °C

PSA：
78.5
XLogP3：
5.32
Appearance：
DryPowder; OtherSolid; PelletsLargeCrystals
Density：
1.27 g/cm3
Melting Point：
93-100 °C
Boiling Point：
410.4±28.0 °C at 760 mmHg
Flash Point：
202.0±24.0 °C
Refractive Index：
1.665
Water Solubility：
INSOL IN WATER; SOL IN BENZENE

N-Dodecane-1-thiol is an alkyl thiol that forms a self-assembled monolayer (SAM)
N-Dodecane-1-thiol can be used as an organic source of sulfur with balanced physio-chemical properties.
N-Dodecane-1-thiol is an oily colorless liquid


CAS NUMBER: 112-55-0

EC NUMBER: 203-984-1

MOLECULAR FORMULA: C12H25SH

MOLECULAR WEIGHT: 202.40 g/mol

IUPAC NAME: dodecane-1-thiol


N-Dodecane-1-thiol has a mild skunk odor
N-Dodecane-1-thiol's freezing point is 19 °F
N-Dodecane-1-thiol can be used as a source of sulfur for the synthesis CdS quantum dots (QDs) and lead sulfide nanoparticles (PbS) which find potential applications in energy efficient lighting, solar cells and as ammonium gas sensing agents.

N-Dodecane-1-thiol is used a an additive to lubricants.
N-Dodecane-1-thiol is used in pH regulators
N-Dodecane-1-thiol is soluble in acetone and benzene

N-Dodecane-1-thiol is commonly used as a chain transfer agent in the manufacturing process of styrene/butadiene latex for use in carpet and paper industries.
N-Dodecane-1-thiol has recently become a significant industrial chemical because of its use as a chain transfer agent in the manufacture of latex.
As an agent, N-Dodecane-1-thiol helps in the polymerization of the end products.
This role used to be given to chloroform, carbon tetrachloride, and other compounds of chlorine.

N-Dodecane-1-thiol may be used to form a self-assembled monolayer (SAM) on copper surface as a corrosion resistant coating.
Functionalization with DDT may form SAMs on geranium (Ge) to improve the surface characteristics for futuristic applications in microelectronics.

This molecule is used for the production of hydrophobic SAMs.
N-Dodecane-1-thiol can also be used in mixed SAMs to give a hydrophobic background and act as a spacer to move other functional groups or domains farther apart

N-Dodecane-1-thiol is a polymerization regulator of synthetic rubber, synthetic resin and synthetic fiber
N-Dodecane-1-thiol is commonly used in the manufacture of styrene-butadiene rubber and ABS resin.

N-Dodecane-1-thiol appears as a colorless liquid with a repulsive odor.
N-Dodecane-1-thiol is colorless oil liquid, and diffuses foul smell.

N-Dodecane-1-thiol can be found in complex articles, with no release intended: vehicles.
N-Dodecane-1-thiol can be found in products with material based on leather (e.g. gloves, shoes, purses, furniture).

N-Dodecane-1-thiol is used in polymers.
N-Dodecane-1-thiol is used in the following products:
-coating products
-leather treatment products
-polymers

N-Dodecane-1-thiol is commonly used in the manufacturing process of polymers based on butadiene and styrene
N-Dodecane-1-thiol is not soluble in water and slightly soluble in light alcohols
N-Dodecane-1-thiol is soluble in styrene and most organic solvents.

N-Dodecane-1-thiol is used for the manufacture of
-chemicals
-textile
-leather
-fur

N-Dodecane-1-thiol is used in lubricant intermediates
N-Dodecane-1-thiol is a chain transfer agent used mainly in cold radical polymerization processes.
N-Dodecane-1-thiol can also be used in the polymerization of various monomers

N-Dodecane-1-thiol is an organosulfur compound
N-Dodecane-1-thiol is a colorless liquid
N-Dodecane-1-thiol is commonly used as a chain transfer agent

N-Dodecane-1-thiol is used as an intermediate, as a process regulator, and as an additive to lubricants.
N-Dodecane-1-thiol is used in polymers and pH regulators
N-Dodecane-1-thiol has an industrial use resulting in the manufacture of another substance (use of intermediates).

N-Dodecane-1-thiol is used in mining.
N-Dodecane-1-thiol is used in the manufacture of chemicals and rubber products.

N-Dodecane-1-thiol is a polymerization regulator of synthetic rubber, synthetic resin and synthetic fiber
N-Dodecane-1-thiol is commonly used in the manufacture of styrene-butadiene rubber and ABS resin.

N-Dodecane-1-thiol is used in the manufacture of fungicides, insecticides, rust inhibitors, lubricating oil additives, drugs, etc.
N-Dodecane-1-thiol can also be used as "gold water" in the ceramic industry and an acidifier for oil wells.

N-Dodecane-1-thiol is also called n-dodecyl mercaptan, which is a clear liquid.
N-Dodecane-1-thiol's melting point is -7 °C
N-Dodecane-1-thiol's flash point is 87 °C.
N-Dodecane-1-thiol is stable under normal temperatures and pressures.

N-Dodecane-1-thiol can be used as a chain transfer agent in the polymerization of methyl methacrylate.
For example, the effect of N-Dodecane-1-thiol as a chain transfer agent on the molecular weight of poly(methyl methacrylate) has been studied
The transfer constant of N-Dodecane-1-thiol was calculated at different temperatures; the activation energy and frequency factor for an Arrhenius equation of transfer constant were then obtained.


PHYSICAL PROPERTIES:

-Molecular Weight: 202.40 g/mol

-XLogP3: 6.1

-Exact Mass: 202.17552200 g/mol

-Monoisotopic Mass: 202.17552200 g/mol

-Topological Polar Surface Area: 1Ų

-Physical Description: Oily colorless liquid with a mild skunk odor

-Color: water-white, or pale-yellow

-Form: oily liquid

-Odor: Mild, skunk-like odor.

-Boiling Point: 142-145 °C

-Melting Point: 19 °F

-Flash Point: 190 °F

-Solubility: Insoluble in water

-Density: 0.85

-Vapor Density: >1

-Vapor Pressure: 0.00853 mmHg

-Heat of Combustion: -10,100 cal/g

-Heat of Vaporization: 60 cal/g

-Surface Tension: 30 Dynes/cm

-Refractive Index: 1.454-1.464


N-Dodecane-1-thiol appears as a colorless liquid with a repulsive odor.
N-Dodecane-1-thiol is colorless oil liquid, and diffuses foul smell.
N-Dodecane-1-thiol is insoluble in water, soluble in alcohol, ether, acetone, benzene, gasoline and other organic solvents and esters.
N-Dodecane-1-thiol is mainly used as molecular weight modifier.


CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 1

-Hydrogen Bond Acceptor Count: 1

-Rotatable Bond Count: 10

-Heavy Atom Count: 13

-Formal Charge: 0

-Complexity: 81.2

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

-Chemical Classes: Other Classes -> Thiols


N-Dodecane-1-thiol, an organic molecular sulfur, has been utilized as the sulfur source for cadmium sulfide (CdS) "magic-sized" quantum dots (MSQDs) production
For example, CdS quantum dot (QD) nanoparticles have been synthesized using a cadmium salt and 1-dodecanethiol, an organic sulfur, as the cadmium and sulfur sources, respectively, along with a long-chain organic acid (myristic acid, lauric acid, or stearic acid).
The acid has dual effects as a surface capping ligand and a solubility controlling agent as well.

N-Dodecane-1-thiol can be used for the synthesis of thiol-stabilized metal nanoparticles (NPs), such as gold nanoparticles and silver nanoparticles, which have been produced for use as catalysts, electronic devices, fillers, sensors and active components in composite materials, and other applications.
As an example, silver nanoparticles, which were produced by the borohydride reduction of silver nitrate, were stabilized by means of 1-dodecanethiol providing sulfur atom in two phase system involving water and organic solvent (such as toluene, chloroform and hexane)
Different organic solvent played a major role in the particle size of silver nanoparticles.
As a result, N-Dodecane-1-thiol-capped silver nanoparticles were found to serve as effective catalysts to activate the reduction of 4-nitrophenol (4NP) in the presence of NaBH4, where the size of silver nanoparticles played the determining role in catalytic activity.
N-Dodecane-1-thiol can also be used for development of the 1-dodecanethiol-based phase transfer protocol for the highly efficient extraction of noble metal ions from aqueous phase

USES:
N-Dodecane-1-thiol is used in a variety of scientific and industrial applications, including the synthesis of polymers, pharmaceuticals, and other materials.
N-Dodecane-1-thiol is commonly used as a chain transfer agent in the manufacturing process of styrene/butadiene latex for use in carpet and paper industries
N-Dodecane-1-thiol is used as an intermediate

N-Dodecane-1-thiol is used as a process regulator
N-Dodecane-1-thiol can be used as an additive to lubricants.

N-Dodecane-1-thiol appears as a colorless liquid
N-Dodecane-1-thiol has a repulsive odor.
N-Dodecane-1-thiol is commonly used in the manufacturing process of polymers based on butadiene and styrene.

N-Dodecane-1-thiol is an intermediate in organic synthesis, used to manufacture drugs, pesticides, fungicides, rust inhibitors, lubricant additives, etc.
N-Dodecane-1-thiol can also be used as "gold water" in the ceramic industry.
N-Dodecane-1-thiol is a relative molecular mass adjuster for the polymerization of synthetic rubber, synthetic resin, and synthetic fiber, especially in the synthesis of styrene-butadiene rubber and ABS resin by emulsion polymerization, which can reduce the branching degree of polymer molecular chains

N-Dodecane-1-thiol makes the relative molecular mass distribution uniform.
N-Dodecane-1-thiol is the best relative molecular mass regulator and chain transfer agent in polymerization processes such as styrene-butadiene rubber, nitrile rubber, and synthetic resin.

N-Dodecane-1-thiol is used in the preparation of hydrophobic or mixed self-assembled monolayers.
N-Dodecane-1-thiol is also employed as a chain transfer agent for radical polymerization.
Further, N-Dodecane-1-thiol is utilized as a polymerization inhibitor in polyurethane and neoprene adhesives, which finds application in the footwear industry.
In addition to this, N-Dodecane-1-thiol acts as a protein regenerating agent used for the regeneration of native proteins from mercuribenzoate.

N-Dodecane-1-thiol has an industrial use resulting in manufacture of another substance (use of intermediates).
N-Dodecane-1-thiol is a colourless liquid organic compound, with a characteristic odour.
N-Dodecane-1-thiol is used as an intermediate and a chain transfer agent.
Products containing N-Dodecane-1-thiol are commercially available to industrial customers only.

N-Dodecane-1-thiol is used for the production of hydrophobic Self-assembled Monolayers (SAMs).
N-Dodecane-1-thiol can also be used in mixed SAMs to give a hydrophobic background and act as a spacer to move other functional groups or domains farther apart.
Also, N-Dodecane-1-thiol is a useful protein regenerating agent for regenerating native proteins from mercuribenzoate.

N-Dodecane-1-thiol is soluble in methanol, ether, acetone, benzene, gasoline and acetate
N-Dodecane-1-thiol is insoluble in water.

N-Dodecane-1-thiol is used in lubricant intermediates to produce additives as well as final components to improve lubricant performance in base oils and metal working fluids.
N-Dodecane-1-thiol is a main component to produce metallic decoration (inks) for food packaging (porcelain, ceramics glass).
N-Dodecane-1-thiol is also a lubricant additive used to improve lubricant performance in base oils and metal working fluids.

N-Dodecane-1-thiol can also be used in the polymerization of various monomers, such as vinyl chloride and chlorotrifluoroethylene.
N-Dodecane-1-thiol is used as a chemical intermediate in various syntheses: extreme pressure additives, fragrances, non-ionic surfactants and fungicides.

N-Dodecane-1-thiol is an organosulfur compound
N-Dodecane-1-thiol's molecular formula is C12H25SH.
N-Dodecane-1-thiol is colorless to pale yellow viscous liquid.

N-Dodecane-1-thiol is commonly used as a chain transfer agent in the manufacturing process of styrene/butadiene latex for use in carpet and paper industries.
N-Dodecane-1-thiol is a polymerization regulator of synthetic rubber, synthetic resin and synthetic fiber, especially commonly used in the manufacture of styrene-butadiene rubber
N-Dodecane-1-thiol is mainly used as a polymerization regulator for synthetic rubber, synthetic fibers, and synthetic resins
N-Dodecane-1-thiol is also used in the production of polyvinyl chloride stabilizers, drugs, insecticides, fungicides, detergents, surface hydrophobic modifiers, etc.


SYNONYMS:

1-DODECANETHIOL
Dodecane-1-thiol
112-55-0
Dodecyl mercaptan
Dodecanethiol
Lauryl mercaptan
n-Dodecanethiol
n-Dodecyl mercaptan
N-Dodecylmercaptan
1-Mercaptododecane
n-Lauryl mercaptan
1-Dodecyl mercaptan
Dodecylmercaptan
1-dodecylthiol
TERT-DODECANETHIOL
N-Dodecane-1-thiol
t-Dodecanethiol
Sulfole 120
t-DDM
2,3,3,4,4,5-hexamethylhexane-2-thiol
t-Dodecylmercaptan
G00MDQ58TB
DTXSID1025221
NCGC00091163-03
CCRIS 6030
tert-Lauryl Mercaptan
terc.Dodecylmerkaptan
EINECS 246-619-1
terc.Dodecylmerkaptan
BRN 1738382
2,3,3,4,4,5-Hexamethyl-2-hexanethiol
TERT-DODECYL THIOL
T-DODECYL MERCAPTAN
UNII-G00MDQ58TB
DTXCID905221
SCHEMBL3332338
CHEMBL1325985
Tox21_400018
AKOS015900250
n-(2-chloroethyl)-n-(3-pyridinyl)urea
NCGC00091163-01
NCGC00091163-02
NCGC00091163-04
CAS-25103-58-6
EC 246-619-1
Q2405872
2,3,3,4,4,5-hexamethylhexane-2-thiol
2-methylundecane-2-thiol
dodecane-1-thiol
Dodecyl mercaptan
TDM
TDM (N-Dodecane-1-thiol)
tert-Dodecanethiol
2-Methylundecane-2-thiol
2-Undecanethiol, 2-methyl-
2-Nonyl-2-propanethiol
2-Methylundecyl-2-thiol
tertiary dodecyl mercaptan
2-methyl-2-undecanethiol
2-methyl-undecane-2-thiol
SCHEMBL21128
1,1-Dimethyl-decyl-mercaptan
SCHEMBL564605
C12H26S
DTXSID00143406
1,1-Dimethyldecyl hydrosulfide
ZINC597503
tert-dodecanethiol
Tert-Dodecanethiol
tert-Dodecanethiol
tert-Dodecanthiol
N-Dodecane-1-thiol
N-Dodecane-1-thiol (mixture of isomers)
TDM
TDDM
tert-Dodecanethiol
tert-dodecylmercaptan
N-Dodecane-1-thiol
dodecanethiol, mixed isomers
2,3,3,4,4,5-hexamethylhexane-2-thiol
tert-Dodecanethiol (mixture of isomers)
t-dodecanethiol
2,2,4,6,6-Pentamethyl-4-heptanethiol
2,2,4,6,6-Pentaméthyl-4-heptanethiol
2,2,4,6,6-Pentamethyl-4-heptanthiol
2,2,4,6,6-Pentamethylheptane-4-thiol
25103-58-6
296-714-7
4-Heptanethiol, 2,2,4,6,6-pentamethyl-
MFCD00043233
tert-Dodecylmercaptan
tert-Dodecanethiol
tert-Dodecanethiol (mixture of isomers)
N-Dodecane-1-thiol
tert-dodecylthiol
Pennfloat M
Pennfloat S
n-Dodecylthiol
Lauryl mercaptide
M-Lauryl mercaptan
M-Dodecyl mercaptan
Dodecylthiol
Dodecyl mercaptan (VAN)
NSC 814
NCI-C60935
Thiokalcol 20
CCRIS 743
HSDB 1074
EINECS 203-984-1
BRN 0969337
UNII-S8ZJB6X253
AI3-07577
S8ZJB6X253
1322-36-7
DTXSID6025220
NSC-814
EC 203-984-1
DTXCID505220
Tris(dodecylthio)antimony
CAS-112-55-0
dodecanthiol
laurylmercaptan
Dodecanethiols
dodecane thiol
Dodecyl thiol
N-dodecanotiol
1-dodecanotiol
1-dodecanthiol
N-Dodeciltiol
dodecyl-mercaptan
1-Dodeciltiol
mercaptano laurilo
1-dodecane thiol
Dodecil mercaptano
Thiokalcohl 20
1-dodecylmercaptan
1-Mercaptododecano
n-dodecyl-mercaptan
Isododecyl mercaptan
N-mercaptano Lauril
Dodecanethiol-(1)
MFCD00004885
N-mercaptano dodecilo
1-mercaptano dodecilo
normal dodecylmercaptan
normal dodecyl mercaptan
6939-83-9
Dodecyl mercaptan (6CI)
1-Dodecanethiol, >=98%
Dodecanotiol (8CI, 9CI)
SCHEMBL15369
DODECANE, 1-MERCAPTO
NSC814
1-DODECANETHIOL [HSDB]
CHEMBL3185403
FEMA NO. 4581
NSC11884
EINECS 215-338-6
LS-555
NSC-11884
NSC229570
STL483072
WLN: 12S-SB-S12&S12
AKOS015960383
NSC-229570
NCGC00249113-01
NCGC00257179-01
NCGC00259307-01
BP-10739
1-Dodecanethiol, purum, >=97.0% (GC)
D0970
FT-0607709
FT-0693266
FT-0694976
EN300-1859909
Q161619
J-504580
Dodecanethiol, 1-; (Dodecyl mercaptan; Lauryl mercaptan)
30237-11-7
1-Dodecanethiol
1-Dodecanthiol
Dodecane-1-thiol
dodecane-1-thiol
Dodecane-1-thiol
dodecane-1-thiol
Dodecyl Mercaptan
N-Dodecyl Mercaptan
N-Dodecyl mercaptan
n-dodecyl mercaptane
n-Dodecylmercaptan

N-Dodecanoic acid is a white, powdery solid with a faint odor of bay oil or soap.
N-Dodecanoic acid, Reagent, also known as Vulvic acid, is a medium chain fatty acid that has a vague smell of soap and is a powder.
N-Dodecanoic acid is a proton pump inhibitor potentially for the treatment of helicobacter pylori infections.


CAS Number: 143-07-7
EC Number: 205-582-1
MDL Number: MFCD00004440
Molecular formula: C10H18O4 / HOOC(CH2)8COOH



SYNONYMS:
Dodecanoic acid, n-Dodecanoic acid, Dodecylic acid, Dodecoic acid, Laurostearic acid, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, C12:0 (Lipid numbers), Laurostearic acid, Laurates, NSC 5026, Vulvic acid, 1-Dodecanoic acid, Dodecanoates, Lauric acid, Dodecylic acid, 1-Undecanecarboxylic acid, FA12:0, n-Dodecanoic acid, lauric acid, n-dodecanoic acid, dodecylic acid, vulvic acid, laurostearic acid, dodecoic acid, duodecylic acid, 1-undecanecarboxylic acid, aliphat no. 4, neo-fat 12, Decanedioic acid, 1,8-Octanedicarboxylic acid, Decane-1,10-dioic acid, sebacic acid, DECANEDIOIC ACID, 111-20-6, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid, Sebacic acids, Sebacinsaure, Decanedicarboxylic acid, n-Decanedioic acid, Acide sebacique, Sebacinsaeure, USAF HC-1, Ipomic acid, Seracic acid, Decanedioic acid, homopolymer, NSC 19492, UNII-97AN39ICTC, 1,8-dicarboxyoctane, 26776-29-4, NSC19492, 97AN39ICTC, octane-1,8-dicarboxylic acid, CHEBI:41865, NSC-19492, DSSTox_CID_6867, DSSTox_RID_78231, DSSTox_GSID_26867, SebacicAcid, CAS-111-20-6, CCRIS 2290, EINECS 203-845-5, BRN 1210591, n-Decanedioate, Iponic acid, AI3-09127, disodium-sebacate, 4-oxodecanedioate, MFCD00004440, 1,10-Decanedioate, Sebacic acid, 94%, Sebacic acid, 99%, Dicarboxylic acid C10, 1i8j, 1l6s, 1l6y, 1,8-Octanedicarboxylate, WLN: QV8VQ, SEBACIC ACID, EC 203-845-5, SCHEMBL3977, NCIOpen2_008624, SEBACIC ACID, 4-02-00-02078, SEBACIC ACID, CHEMBL1232164, DTXSID7026867, Sebacic acid, >=95.0% (GC), ZINC1531045, Tox21_201778, Tox21_303263, BBL011473, LMFA01170006, s5732, STL146585, AKOS000120056, CCG-266598, CS-W015503, DB07645, GS-6713, HY-W014787, NCGC00164361-01, NCGC00164361-02, NCGC00164361-03, NCGC00257150-01, NCGC00259327-01, BP-27864, NCI60_001628, DB-121158, FT-0696757, C08277, A894762, C10-120, C10-140, C10-180, C10-220, C10-260, C10-298, Q413454, Q-201703, Z1259273339, 301CFA7E-7155-4D51-BD2F-EB921428B436, 1,8-Octanedicarboxylic acid, Decanedioic acid, Octane-1,8-dicarboxylic acid, 1,10-Decanedioic Acid, 1,8-Octanedicarboxylic Acid, NSC 19492, NSC 97405, n-Decanedioic Acid, 1,10-Decanedioate, 1,10-Decanedioic acid, 1,8-Dicarboxyoctane, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4,7-dioxosebacic acid, 4-Oxodecanedioate, 4-oxodecanedioate, 4-Oxodecanedioic acid, 1,10-Decanedioic acid, 1,8-Dicarboxyoctane, Decanedioic acid, Sebacinsaeure, 1,10-Decanedioate, Decanedioate, Sebacate, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4-Oxodecanedioate, 4-Oxodecanedioic acid, Acide sebacique, Decanedicarboxylic acid, Dicarboxylic acid C10, Ipomic acid, N-Decanedioate, N-Decanedioic acid, Sebacic acids, Sebacinsaure, Seracic acid, Sebacic acid, aluminum salt, Sebacic acid, monocadmium salt, Sebacic acid, sodium salt, DECANEDIOIC ACID, sebacic, USAF hc-1, acidesebacique, SEBACIC ACID pure, n-Decanedioic acid, 1,10-Decanedioic acid, Decanedicarboxylic acid, sebacate (decanedioate), 1,8-OCTANEDICARBOXYLIC ACID, 1,10-Decanedioate, 1,10-Decanedioic acid, 1,8-Octanedicarboxylate, 1,8-Octanedicarboxylic acid, 4,7-Dioxosebacic acid, 4-Oxodecanedioate, 4-Oxodecanedioic acid, Acide sebacique, Decanedicarboxylic acid, Decanedioate, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid, n-Decanedioic acid, 4-Oxodecanedioate, 1,8-Dicarboxyoctane, Octane-1,8-dicarboxylic acid, Sebacic acid, Ipomic acid, Seracic acid, lauric acid, DODECANOIC ACID, 143-07-7, n-Dodecanoic acid, Dodecylic acid, Laurostearic acid, Vulvic acid, Dodecoic acid, Duodecylic acid, 1-Undecanecarboxylic acid, Aliphat No. 4, Ninol AA62 Extra, Wecoline 1295, Hydrofol acid 1255, Hydrofol acid 1295, Duodecyclic acid, Hystrene 9512, Univol U-314, Lauric acid, pure, Dodecylcarboxylate, Lauric acid (natural), Laurinsaeure, Undecane-1-carboxylic acid, ABL, NSC-5026, FEMA No. 2614, laurate, C-1297, Philacid 1200, CCRIS 669, C12:0, Emery 651, Lunac L 70, CHEBI:30805, HSDB 6814, EINECS 205-582-1, UNII-1160N9NU9U, BRN 1099477, n-Dodecanoate, Kortacid 1299, Dodecanoic Acid Anion, DTXSID5021590, Prifrac 2920, AI3-00112, Lunac L 98, Univol U 314, Prifac 2920, 1160N9NU9U, MFCD00002736, DAO, DTXCID801590, CH3-[CH2]10-COOH, NSC5026, EC 205-582-1, dodecylate, laurostearate, vulvate, 4-02-00-01082 (Beilstein Handbook Reference), DODECANOIC ACID (LAURIC ACID), 1-undecanecarboxylate, LAURIC ACID (USP-RS), LAURIC ACID [USP-RS], CH3-(CH2)10-COOH, 8000-62-2, CAS-143-07-7, SMR001253907, laurinsaure, dodecanic acid, Nuvail, lauric-acid, Acide Laurique, 3uil, Lauric acid (NF), DODECANOICACID, fatty acid 12:0, Lauric Acid, Reagent, Nissan NAA 122, Emery 650, Dodecanoic acid, 98%, Dodecanoic acid, 99%, Guaranteed Reagent,99%, Dodecanoic (Lauric) acid, LAURIC ACID [MI], bmse000509, LAURIC ACID [FCC], LAURIC ACID [FHFI], SCHEMBL5895, NCIOpen2_009480, MLS002177807, MLS002415737, WLN: QV11, Dodecanoic acid (lauric acid), LAURIC ACID [WHO-DD], Dodecanoic acid, >=99.5%, Edenor C 1298-100, DODECANOIC ACID [HSDB], CHEMBL108766, GTPL5534, NAA 122, NAA 312, HMS2268C14, HMS3649N06, HY-Y0366, STR08039, Dodecanoic acid, analytical standard, Lauric acid, >=98%, FCC, FG, Tox21_202149, Tox21_303010, BDBM50180948, LMFA01010012, s4726, STL281860, AKOS000277433, CCG-266587, DB03017, FA 12:0, HYDROFOL ACID 1255 OR 1295, NCGC00090919-01, NCGC00090919-02, NCGC00090919-03, NCGC00256486-01, NCGC00259698-01, AC-16451, BP-27913, DA-64879, Dodecanoic acid, >=99% (GC/titration), LAU, Dodecanoic acid, purum, >=96.0% (GC), Lauric acid, natural, >=98%, FCC, FG, CS-0015078, L0011, NS00008441, EN300-19951, C02679, D10714, A808010, LAURIC ACID (CONSTITUENT OF SAW PALMETTO), Q422627, SR-01000838338, J-007739, SR-01000838338-3, BRD-K67375056-001-07-9, F0001-0507, LAURIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC], Z104476194, 76C2A2EB-E8BA-40A6-8032-40A98625ED7B, Lauric acid, European Pharmacopoeia (EP) Reference Standard, Lauric acid, United States Pharmacopeia (USP) Reference Standard, Lauric Acid, Pharmaceutical Secondary Standard; Certified Reference Material, 203714-07-2, 7632-48-6, InChI=1/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14, 1-Undecanecarboxylate, 1-Undecanecarboxylic acid, ABL, Acide Laurique, C12 fatty acid, C12:0, Coconut oil fatty acids, DAO, Dodecanoate, dodecanoic acid, dodecoate, Dodecoic acid, Dodecylate, dodecylcarboxylate, Dodecylic acid, duodecyclate, Duodecyclic acid, duodecylate, Duodecylic acid, LAP, LAU, Laurate, Lauric acid, Laurinsaeure, Laurostearate, Laurostearic acid, MYR, n-Dodecanoate, n-Dodecanoic acid, Sorbitan laurate, Sorbitan monolaurate (NF), undecane-1-carboxylate, Undecane-1-carboxylic acid, Vulvate, Vulvic acid, CH3-[CH2]10-COOH, Dodecylcarboxylic acid, Laate, Laic acid, Aliphat no. 4, Edenor C 1298-100, Emery 651, Hystrene 9512, Kortacid 1299, Lunac L 70, Lunac L 98, Neo-fat 12, Neo-fat 12-43, Nissan naa 122, Philacid 1200, Prifac 2920, Univol u 314, 1-Dodecanoic acid, FA(12:0), 1-Undecanecarboxylic acid, ABL, Aliphat no. 4, C12 fatty acid, Coconut oil fatty acids, Dodecanoate, Dodecanoic (lauric) acid, Dodecanoic acid (lauric acid), Dodecoic acid, Dodecylcarboxylate, Dodecylic acid, Duodecyclic acid, Duodecylic acid, Emery 650, Lauric acid, Lauric acid, pure, Laurinsaeure, Laurostearic acid, Lunac L 70, n-Dodecanoic Acid, N-Dodecanoate, Neo-fat 12, Ninol aa62 extra, Undecane-1-carboxylic acid, Univol U 314, Univol U-314, Vulvic acid, AI3-00112, BRN 1099477, C-1297, CCRIS 669, EINECS 205-582-1, FEMA NO. 2614, HSDB 6814, HYDROFOL ACID 1255, HYDROFOL ACID 1295, HYSTRENE 9512, NEO-FAT 12-43, PHILACID 1200, PRIFRAC 2920, WECOLINE 1295, 1-Undecanecarboxylic acid, ABL, AC-16451, AC1L1GY2, AC1Q5W8C, AKOS000277433, Aliphat No. 4, CH3-[CH2]10-COOH, Coconut oil fatty acids, DAO, DODECANOIC ACID, DODECANOIC ACID (LAURIC ACID), Dodecanoate, Dodecanoic (Lauric) acid, Dodecanoic acid (lauric acid), Dodecanoic acid(Lauric acid), Dodecoic acid, Dodecylcarboxylate, Dodecylic acid, Duodecyclic acid, Duodecylic acid, Emery 650, Hydrofol acid 1255, Hydrofol acid 1295, Hystrene 9512, I04-1205, L-ALFA-LYSOPHOSPHATIDYLCHOLINE, LAUROYL, L0011, LAP, LAU, Lauric acid, pure, Laurinsaeure, Laurostearic acid, Lunac L 70, Neo-fat 12, Neo-fat 12-43, Ninol AA62 Extra, Philacid 1200, Prifrac 2920, SMR001253907, ST023796, Undecane-1-carboxylic acid, Univol U-314, Vulvic acid, Wecoline 1295, [2-((1-OXODODECANOXY-(2-HYDROXY-3-PROPANYL))-PHOSPHONATE-OXY)-ETHYL]-TRIMETHYLAMMONIUM, n-Dodecanoate, n-Dodecanoic acid, nchembio.364-comp10, Dodecanoic acid, n-Dodecanoic acid, Neo-fat 12, Aliphat no. 4, Abl, Dodecylic acid, Lauric acid, Laurostearic acid, Neo-fat 12-43, Ninol aa62 extra, Univol u-314, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, C-1297, Coconut oil fatty acids, Hydrofol acid 1255, Hydrofol acid 1295, Wecoline 1295, Dodecoic acid, Hystrene 9512, Lunac L 70, Duodecyclic acid, Emery 650, n-Dodecanoate, Philacid 1200, Prifrac 2920, Undecane-1-carboxylic acid, C-1297, dodecanoic acid, dodecoic acid, duodecylic acid, ndodecanoic acid, Hydrofol acid 1255, Hydrofol acid 1295, Hystrene 9512, laurostearic acid, Neo-fat 12, Neo-fat 12-43, Ninol AA62 Extra, 1-undecanecarboxylic acid, vulvic acid, Wecoline 1295, Dodecoic acid, Duodecyclic acid, Edenor C 1298-100, Emery 650, Hydrofol acid 1295, Hystrene 9512, Kortacid 1299, Laurostearate, Lunac L 70, Lunac L 98, Neo-fat 12, Ninol AA62 extra, Nissan naa 122, Philacid 1200, Prifac 2920, Prifrac 2920, Univol U 314, Vulvate, Vulvic acid, Wecoline 1295, 1-Undecanecarboxylate, 1-Undecanecarboxylic acid, Dodecylate, Dodecylcarboxylate, Dodecylic acid, Duodecylic acid, Laurostearic acid, n-Dodecanoic acid, Undecane-1-carboxylic acid, LAP, LAU, DAO, lauric acid, n-dodecanoic acid, dodecylic acid, vulvic acid, laurostearic acid, dodecoic acid, duodecylic acid, 1-undecanecarboxylic acid, aliphat no. 4, neo-fat 12, 143-07-7, 205-582-1, 1-UNDECANECARBOXYLIC ACID, DODECANOIC ACID, DODECANOIC ACID [HSDB], DODECOIC ACID, FEMA NO. 2614, LAURATE, LAURIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC], LAURIC ACID [FCC], LAURIC ACID [FHFI], LAURIC ACID [MI], LAURIC ACID [USP-RS], LAURIC ACID [WHO-DD], LAUROSTEARIC ACID, N-DODECANOIC ACID, NSC-5026, Dodecanoic acid, Lauric acid, Laurostearic acid, 1-Undecanecarboxylic acid, ABL, Aliphat No. 4, Univol U 314, Dodecylic acid, Vulvic acid, Neo-Fat 12-43, n-Dodecanoic acid, Neo-Fat 12, Lunac L 70, Emery 651, Prifac 2920, Nissan NAA 122, Lunac L 98, Hystrene 9512, NAA 312, Kortacid 1299, Philacid 1200, Edenor C 1298-100, NSC 5026, NAA 122, Prifac 2922, Edenor C 12, Prifrac 2920, ContraZeck, 1-Dodecanoic acid, Imex C 1299, Palmac 98-12, Edenor 12/98-100, Palmera B 1231, Edenor C 12-98-100, Lasacid FC 12, Laurates, Dodecanoates, Palmae 99-12, D 97385, Edenor C12-99, Coconut Hard 34, Coconut Hard 42, Radiacid 0624, NS 6, 7632-48-6, 8000-62-2, 8045-27-0, 203714-07-2, 55621-34-6, DODECANOIC ACID, C12, Emery651, Vulvic acid, FEMA 2614, lauric acid, pure, N-DODECANOIC ACID, LAUROSTEARIC ACID, Lauric acid 98-101 % (acidimetric), Fatty acid methyl ester sulfonate (MES), Dodecanoic D23 Acid, Dodecanoic Acid-d23,1-Dodecanoic Acid-d23, 1-Undecanecarboxylic Acid-d23, ABL-d23, Aliphat No. 4-d23, ContraZeck-d23, Dodecylic Acid-d23, Edenor C 12-d23,Edenor C 1298-100-d23, Emery 651-d23, Hystrene 9512-d23, Imex C 1299-d23, Kortacid 1299-d23, Laurostearic Acid-d23, Lunac L 70-d23, Lunac L 98-d23, NAA 122-d23, NAA 312-d23, NSC 5026-d23, Neo-Fat 12-d23, Neo-Fat 12-43-d23, Nissan NAA 122-d23, Philacid 1200-d23, Prifac 2920-d23, Prifac 2922-d23, Prifrac 2920-d23, Univol U 314-d23, Vulvic Acid-d23, n-Dodecanoic Acid-d23, Dodecanoate, Coconut Oil Fatty Acids, Laurostearic Acid, N-Dodecanoic Acid, C12 Fatty Acid, Duodecyclic Acid, Vulvic Acid, Dodecanoic Acid (Lauric Acid), Duodecylic Acid, N-Dodecanoate, Dodecanoic (Lauric) Acid, Laurinsaeure, Lauric Acid, Pure, Lauric Acid (Natural), Dodecylcarboxylate, Abl, Dao, Lap, Lau, Myr



N-Dodecanoic acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of N-Dodecanoic acid are known as laurates.
N-Dodecanoic acid is a saturated fatty acid with a terminal carboxylic acid.


The terminal carboxylic acid, N-Dodecanoic acid, can react with primary amine groups in the presence of activators such as HATU.
N-Dodecanoic acid is a carbon 13 labeled form of a saturated fatty acid found in coconut milk, coconut oil, laurel oil, and palm kernel oil, as well as in human breast milk and other animal milks.


N-Dodecanoic acid is a saturated fatty acid with the structural formula CH3(CH2)10COOH .
N-Dodecanoic acid is the main acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
N-Dodecanoic acid is also found in human milk(5.8% of total fat), cows milk(2.2%), and goat milk(4.5%).


N-Dodecanoic acid is a white, powdery solid with a faint odor of bay oil or soap.
N-Dodecanoic acid, Reagent, also known as n-Dodecanoic acid, is a medium chain fatty acid that has a vague smell of soap and is a powder.
N-Dodecanoic acid is found naturally in human breast milk as well as cow's and goat's milk.


N-Dodecanoic acid's reagent grade means this is the highest quality commercially available for this chemical and that the American Chemical Society has not officially set any specifications for this material.
N-Dodecanoic acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.


N-Dodecanoic acid is a solid at room temperature but melts easily in boiling water, so liquid N-Dodecanoic acid can be treated with various solutes and used to determine their molecular masses.
N-Dodecanoic acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.



N-Dodecanoic acid is a proton pump inhibitor potentially for the treatment of helicobacter pylori infections.
In vitro experiments have suggested that some fatty acids including N-Dodecanoic acid could be a useful component in a treatment for acne, but no clinical trials have yet been conducted to evaluate this potential benefit in humans.


N-Dodecanoic acid increases total serum cholesterol more than many other fatty acids.
But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol).
As a result, N-Dodecanoic acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid, either saturated or unsaturated.


N-Dodecanoic acid, identified by CAS number 143-07-7, is a saturated medium-chain fatty acid with a 12-carbon atom backbone, prominently known for its role in the manufacturing of soaps, detergents, and cosmetics.
As a fundamental component, N-Dodecanoic acid is celebrated for its surfactant properties, which enable the production of a rich lather in cleansing products.


In research, N-Dodecanoic acid is extensively used to study lipid behavior in various systems due to its amphiphilic nature, which allows it to assemble into micelles and other nanostructures in aqueous solutions.
These studies are crucial for advancing the fields of material science and nanotechnology, particularly in the development of delivery systems and the enhancement of product formulations.


Additionally, N-Dodecanoic acid is employed in food science research where it serves as a model to understand the digestion and metabolism of medium-chain fatty acids.
N-Dodecanoic acid's antimicrobial properties are also examined in terms of how they can be leveraged in non-medical applications, such as in food preservation and safety, where reducing microbial growth is essential.


Moreover, N-Dodecanoic acid′s role in industrial applications extends to its use as a raw material in the synthesis of various chemical derivatives, including esters used in flavorings and fragrances, showcasing its versatility and importance in both scientific research and industrial applications.
N-Dodecanoic acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


N-Dodecanoic acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
N-Dodecanoic acid, C12H24O2, also known as n-Dodecanoic acid, is a saturated fatty acid with a 12-carbon atom chain.
The powdery, white crystalline acid, N-Dodecanoic acid, has a slight odor of oil of bay and occurs naturally in various plant and animal fats and oils.


N-Dodecanoic acid is a major component of coconut oil and palm kernel oil.
N-Dodecanoic acid, CAS 143-07-7, chemical formula C12H24O2, is produced as a white crystalline powder, has a slight odor of bay oil, and is soluble in water, alcohols, phenyls, haloalkanes, and acetates.


N-Dodecanoic acid derives from a hydride of a dodecane.
N-Dodecanoic acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.
N-Dodecanoic acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.


N-Dodecanoic acid is a metabolite found in or produced by Escherichia coli.
N-Dodecanoic acid is a natural product found in Ipomoea leptophylla, Arisaema tortuosum, and other organisms with data available.
N-Dodecanoic acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


N-Dodecanoic acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
N-Dodecanoic acid is the main fatty acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
N-Dodecanoic acid is a white, powdery solid with a faint odor of bay oil.


N-Dodecanoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.
N-Dodecanoic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
N-Dodecanoic acid is a medium-chain saturated fatty acid.


N-Dodecanoic acid is found in many vegetable fats and in coconut and palm kernel oils.
N-Dodecanoic acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


N-Dodecanoic acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.
N-Dodecanoic acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of N-Dodecanoic acid are known as laurates.


N-Dodecanoic acid is a precursor to dilauroyl peroxide, a common initiator of polymerizations.
N-Dodecanoic acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.


N-Dodecanoic acid, also known as dodecanoate or lauric acid, belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
N-Dodecanoic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


N-Dodecanoic acid is the main fatty acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties.
N-Dodecanoic acid is a white, powdery solid with a faint odour of bay oil.
N-Dodecanoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.


N-Dodecanoic acid is a fatty acid that has been shown to inhibit the growth of bacteria.
N-Dodecanoic acid inhibits bacterial growth by binding to the active site of the enzyme dihydrolipoamide acetyltransferase, which catalyzes the conversion of dihydrolipoamide and acetyl-CoA to succinyl-CoA and acetoacetyl-CoA.


N-Dodecanoic acid also binds to dinucleotide phosphate, which is involved in regulation of phase transition temperature and biological samples.
N-Dodecanoic acid has also been shown to act as an active inhibitor of fatty acid synthase, an enzyme that catalyzes the synthesis of fatty acids from acetyl-coenzyme A (acetyl-CoA).


This process is essential for bacterial growth.
N-Dodecanoic acid has synergistic effects with other antibiotics such as ampicillin, erythromycin, and tetracycline.
N-Dodecanoic acid is a saturated medium-chain fatty acid with a 12-carbon backbone.


N-Dodecanoic acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
N-Dodecanoic acid is a medium-length long-chain fatty acid, or lipid, that makes up about half of the fatty acids within coconut oil.
N-Dodecanoic acid’s a powerful substance that is sometimes extracted from the coconut for use in developing monolaurin.


Monolaurin is an antimicrobial agent that is able to fight bacteria, viruses, yeasts, and other pathogens.
Because you can’t ingest N-Dodecanoic acid alone (it’s irritating and not found alone in nature), you’re most likely to get it in the form of coconut oil or from fresh coconuts.


Though coconut oil is being studied at a breakneck pace, much of the research doesn’t pinpoint what in the oil is responsible for its reported benefits.
Because coconut oil contains much more than just N-Dodecanoic acid, it would be a stretch to credit it with all of the coconut oil benefits.
Still, a 2015 analysis suggests that many of the benefits tied to coconut oil are directly linked to N-Dodecanoic acid.


Among the benefits, they suggest N-Dodecanoic acid could aid weight loss and even protect against Alzheimer’s disease.
Its effects on blood cholesterol levels still need to be clarified.
This research suggests that the benefits of N-Dodecanoic acid are due to how the body uses it.


The majority of N-Dodecanoic acid is sent directly to the liver, where it’s converted to energy rather than stored as fat.
When compared with other saturated fats, N-Dodecanoic acid contributes the least to fat storage.
N-Dodecanoic acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.


N-Dodecanoic acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of N-Dodecanoic acid are known as laurates.
Like many other fatty acids, N-Dodecanoic acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.


N-Dodecanoic acid is mainly used for the production of soaps and cosmetics.
For these purposes, N-Dodecanoic acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.


These precursors give mixtures of sodium laurate and other soaps. N-Dodecanoic acid occurs as a white crystalline powder
N-Dodecanoic acid is a saturated fatty acid with a 12-carbon atom chain used in industrial cleaners, lubricants, soaps, surfactants, agricultural additives, coatings, food additives, textile additives.


N-Dodecanoic acid, the saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white, powdery solid with a faint odor of bay oil or soap.
N-Dodecanoic acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil.


Otherwise N-Dodecanoic acid is relatively uncommon.
N-Dodecanoic acid increases total serum cholesterol the most of any fatty acid.
But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol).


As a result, N-Dodecanoic acid has been characterized as having "a more favorable effect on total:HDL cholesterol than any other fatty acid, either saturated or unsaturated."
In general, a lower total/HDL serum cholesterol ratio correlates with a decrease in atherosclerotic risk.


For these purposes, N-Dodecanoic acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
N-Dodecanoic acid is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids.
N-Dodecanoic acid is a white crystalline carboxylic acid with a faint odor of bay oil or soap.


N-Dodecanoic acid has been found at high levels in coconut oil.
N-Dodecanoic acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.


N-Dodecanoic acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.
N-Dodecanoic acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.


N-Dodecanoic acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
N-Dodecanoic acid is a conjugate acid of a dodecanoate.
N-Dodecanoic acid derives from a hydride of a dodecane.


N-Dodecanoic acid is a white crystalline carboxylic acid.
N-Dodecanoic acid is used as a plasticizer and for making detergents and soaps.
N-Dodecanoic acid's glycerides occur naturally in coconut and palm oils.


N-Dodecanoic acid is a white solid with a slight odor of bay oil.
N-Dodecanoic acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.


N-Dodecanoic acid is a white, powdery solid with a faint odour of mild fatty coconut bay oil or soap.
N-Dodecanoic acid is the main fatty acid in coconut oil (49%) and in palm kernel oil (47-50%), and is found in lesser amounts in wild nutmeg, human breast milk, cow’s milk, goat milk, watermelon seeds, plum and macadamia nut.


N-Dodecanoic acid, although slightly irritating to mucous membranes, has an extremely low toxicity, is inexpensive, has antimicrobial properties and so is used in many soaps and shampoos.
N-Dodecanoic acid is a weakly acidic compound.


N-Dodecanoic acid is reacted with sodium hydroxide to generate sodium laurate, which is soap.
N-Dodecanoic acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid either saturated or unsaturated"


N-Dodecanoic acid is non-toxic, safe to handle, inexpensive, and has a long shelf life.
N-Dodecanoic acid is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids.
N-Dodecanoic acid is a white, powdery solid with a faint odor of bay oil or soap.


N-Dodecanoic acid belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
N-Dodecanoic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.


N-Dodecanoic acid is a potentially toxic compound.
N-Dodecanoic acid has the chemical formula C12H24O2.
N-Dodecanoic acid appears as a white crystalline solid with a characteristic odor like oil of bay.


N-Dodecanoic acid is insoluble in Water and soluble in Ether, Chloroform, and Alcohol.
N-Dodecanoic acid is found naturally in some plant and animal fats and is a key component of coconut oil.
N-Dodecanoic acid is synthetically prepared by the fractional distillation of other acids of mixed coconut.


N-Dodecanoic acid is a white solid with a slight odor of bay oil.
N-Dodecanoic acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.


N-Dodecanoic acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.
N-Dodecanoic acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
N-Dodecanoic acid is a conjugate acid of a dodecanoate.



USES and APPLICATIONS of n-DODECANOIC ACID:
Release to the environment of N-Dodecanoic acid can occur from industrial use: industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting) and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).


Other release to the environment of N-Dodecanoic acid is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).


N-Dodecanoic acid can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
N-Dodecanoic acid is also used as a food additive and an active component in a treatment for acne.


N-Dodecanoic acid can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), leather (e.g. gloves, shoes, purses, furniture) and paper used for packaging (excluding food packaging).


N-Dodecanoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
N-Dodecanoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.
N-Dodecanoic acid is also used as a food additive and an active component in a treatment for acne.


N-Dodecanoic acid is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
N-Dodecanoic acid is approved for use as a biocide in the EEA and/or Switzerland, for: repelling or attracting pests.


People also use N-Dodecanoic acid as medicine.
People use N-Dodecanoic acid for viral infections such as the flu, common cold, genital herpes, and many other conditions, but there is no good scientific evidence to support any use.


N-Dodecanoic acid is used in the following products: washing & cleaning products, coating products, fillers, putties, plasters, modelling clay, finger paints, polishes and waxes, air care products and plant protection products.
Other release to the environment of N-Dodecanoic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


In addition to this, N-Dodecanoic acid is a substrate for acylation of certain proteins based on the murine studies.
N-Dodecanoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
N-Dodecanoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.


In addition to this, N-Dodecanoic acid is a substrate for acylation of certain proteins based on the murine studies.
N-Dodecanoic acid is used in the following products: washing & cleaning products, polishes and waxes, adhesives and sealants, cosmetics and personal care products and laboratory chemicals.


N-Dodecanoic acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
N-Dodecanoic acid is used for the manufacture of: textile, leather or fur.


Release to the environment of N-Dodecanoic acid can occur from industrial use: formulation of mixtures and in processing aids at industrial sites.
Other release to the environment of N-Dodecanoic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


N-Dodecanoic acid is used in the following products: polymers, pH regulators and water treatment products, leather treatment products, coating products, fillers, putties, plasters, modelling clay, finger paints, inks and toners, cosmetics and personal care products, lubricants and greases and textile treatment products and dyes.


Industrial applications of N-Dodecanoic acid and its derivatives include the fatty acid as a component of alkyd resins, wetting agents, a rubber accelerator and softener, detergents, and insecticides.
The consumer market uses N-Dodecanoic acid in the cleaning, furnishing, and production of personal care products.


In medicine, N-Dodecanoic acid is known to increase total serum cholesterol more than many of the other fatty acids.
Common Uses and Applications of N-Dodecanoic acid: Additive, Acidifiers, Chemical intermediate, Lubricant, Synthesis of substances, Industries, Chemical Production, Personal Care, and Laboratories.


N-Dodecanoic acid is mainly used in the manufacturing of soaps and other cosmetics.
In scientific laboratories, N-Dodecanoic acid is often used to investigate the molar mass of unknown substances via freezing-point depression.
In industry, N-Dodecanoic acid is used as an intermediate and as a surface active agent.


The consumer market uses N-Dodecanoic acid in the cleaning, furnishing, and production of personal care products.
In medicine, N-Dodecanoic acid is known to increase total serum cholesterol more than many of the other fatty acids.
N-Dodecanoic acid is mainly used in the manufacture and production of soaps and other cosmetics as well as scientific laboratory uses.


N-Dodecanoic acid is used as an intermediate and surface active agent in industry and in the manufacture of personal care products in the consumer market.
N-Dodecanoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
N-Dodecanoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.


N-Dodecanoic acid is also used as a food additive and an active component in a treatment for acne.
In addition to this, N-Dodecanoic acid is a substrate for acylation of certain proteins based on the murine studies.
N-Dodecanoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.


N-Dodecanoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.
N-Dodecanoic acid is also used as a food additive and an active component in a treatment for acne.
In addition to this, N-Dodecanoic acid is a substrate for acylation of certain proteins based on the murine studies.


N-Dodecanoic acid is used in the preparation of cosmetics, soaps, alkyd resins and wetting agents.
N-Dodecanoic acid is also used to measure the molar mass of an unknown substance through freezing point depression.
N-Dodecanoic acid is also used as a food additive and an active component in a treatment for acne.


In addition to this, N-Dodecanoic acid is a substrate for acylation of certain proteins based on the murine studies.
N-Dodecanoic acid is generally used to produce cosmetic products but is also used in the laboratory to obtain the molar mass of substances.
N-Dodecanoic acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and shampoos.


Sodium lauryl sulfate is the most common N-Dodecanoic acid derived compound used for this purpose.
Because N-Dodecanoic acid has a non-polar hydrocarbon tail and a polar carboxylic acid head, it can interact with polar solvents (the most important being water) as well as fats, allowing water to dissolve fats.


This accounts for the abilities of shampoos to remove grease from hair.
Another use is to raise metabolism, believed to derive from N-Dodecanoic acid's activation of 20% of thyroidal hormones, otherwise which lay dormant.
This is supposed from N-Dodecanoic acid's release of enzymes in the intestinal tract which activate the thyroid.


This could account the metabolism-raising properties of coconut oil.
Because N-Dodecanoic acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle, it is often used in laboratory investigations of melting-point depression.


N-Dodecanoic acid is a solid at room temperature but melts easily in boiling water, so liquid it can be treated with various solutes and used to determine their molecular masses.
N-Dodecanoic acid is widely used in cosmetics and food products.


In pharmaceutical applications N-Dodecanoic acid has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery, and intestinal absorption.
N-Dodecanoic acid is also useful for stabilizing oil-in-water emulsions.


N-Dodecanoic acid has also been evaluated for use in aerosol formulations.
N-Dodecanoic acid is used in the production of personal care products via the salt sodium laurate.
N-Dodecanoic acid is also studied in metabolic and foodomics research for its potential impact on cardiovascular disease.


N-Dodecanoic acid has been used as a reagent to synthesize MnFe2O4 magnetic nanoparticles by seed mediated growth method.
N-Dodecanoic acid can undergo esterification with 2-ethylhexanol in the presence of sulfated zirconia catalyst to form 2-ethylhexanoldodecanoate, a biodiesel.
Like many other fatty acids, N-Dodecanoic acid is inexpensive, has a long shelf-life, is nontoxic, and is safe to handle.


N-Dodecanoic acid is used mainly for the production of soaps and cosmetics.
For these purposes, N-Dodecanoic acid is reacted with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.


These precursors give mixtures of sodium laurate and other soaps.
N-Dodecanoic acid is used for the preparation of alkyd resins, as well as wetting agents, detergents and pesticides
N-Dodecanoic acid is used for peeling vegetables and fruits with a maximum amount of 3.0g/kg.


N-Dodecanoic acid is used as defoamer; GB 2760-86 provides for the spices allowed to use; used for the preparation of other food grade additives.
N-Dodecanoic acid is widely used in the surfactant industry and can be, according to the classification of surfactants, divided into cationic, anionic, non-ionic and amphoteric type.


The surfactants types of n-Dodecanoic acid are listed in the attached table of this item.
Some surfactants of the derivatives of n-Dodecanoic acid and dodecanol are also antiseptics, such as dodecyl dimethyl benzyl ammonium chloride (geramine), dodecyl dimethyl benzyl ammonium bromide (bromo-geramine) and dodecyl dimethyl (2-phenoxyethyl) ammonium bromide (domiphen bromide).


The dodecyldimethyllammonium-2,4,5-trichlorophenolate in these derivatives can be used as citrus preservative.
N-Dodecanoic acid also has many applications in plastic additives, food additives, spices and pharmaceutical industries.
Given its foaming properties, the derivatives of lauric acid (h-n-Dodecanoic acid) are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol.


N-Dodecanoic acid is a common constituent of vegetable fats, especially coconut oil and laurel oil.
N-Dodecanoic acid may have a synergistic effect in a formula to help fight against mircoorganisms.
N-Dodecanoic acid is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.


N-Dodecanoic acid is a fatty acid obtained from coconut oil and other veg- etable fats.
N-Dodecanoic acid is practically insoluble in water but is soluble in alcohol, chloroform, and ether.


N-Dodecanoic acid functions as a lubricant, binder, and defoaming agent.
N-Dodecanoic acid is used intermediates of Liquid Crystals
N-Dodecanoic acid is also used as a food additive and an active component in a treatment for acne.


Release to the environment of N-Dodecanoic acid can occur from industrial use: formulation of mixtures and formulation in materials.
N-Dodecanoic acid is used in the following products: washing & cleaning products, leather treatment products, polymers, textile treatment products and dyes, pH regulators and water treatment products and lubricants and greases.


N-Dodecanoic acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
N-Dodecanoic acid is used for the manufacture of: textile, leather or fur.


Release to the environment of N-Dodecanoic acid can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and as processing aid.
Release to the environment of N-Dodecanoic acid can occur from industrial use: manufacturing of the substance.


N-Dodecanoic acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.
N-Dodecanoic acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.


In the laboratory, N-Dodecanoic acid may be used to investigate the molar mass of an unknown substance via the freezing-point depression.
The choice of N-Dodecanoic acid is convenient because the melting point of the pure compound is relatively high (43.8°C).
Its cryoscopic constant is 3.9°C•kg/mol.


By melting N-Dodecanoic acid with the unknown substance, allowing it to cool, and recording the temperature at which the mixture freezes, the molar mass of the unknown compound may be determined.
In industry, N-Dodecanoic acid is used as an intermediate and as a surface active agent.


-Uses of N-Dodecanoic acid in Perfume:
N-Dodecanoic acid is used in Butter flavors and in certain Citrus flavor types, mainly in Lemon.
The concentration of N-Dodecanoic acid used may vasy from 2 to 40 ppm, calculated upon the finished consumer product.


-Pharmaceutical Applications of N-Dodecanoic acid:
pharmaceutical applications it has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery,(14) and intestinal absorption.
N-Dodecanoic acid is also useful for stabilizing oil-in-water emulsions.
N-Dodecanoic acid has also been evaluated for use in aerosol formulations.



SOLUBILITY OF N-DODECANOIC ACID:
N-Dodecanoic acid is soluble in water, benzene, acetone, alcohol, petroleum ether, dimethyl sulfoxide and dimethyl formamide.
N-Dodecanoic acid is slightly soluble in chloroform.



NOTES OF N-DODECANOIC ACID:
N-Dodecanoic acid is incompatible with bases, oxidizing agents and reducing agents.



WHERE TO FIND N-DODECANOIC ACID:
N-Dodecanoic acid is a powerful substance that’s sometimes extracted from the coconut for use in developing monolaurin.
Monolaurin is an antimicrobial agent that’s able to fight pathogens such as bacteria, viruses, and yeasts.



OCCURRENCE OF N-DODECANOIC ACID:
N-Dodecanoic acid, as a component of triglycerides, comprises about half of the fatty-acid content in coconut milk, coconut oil, laurel oil, and palm kernel oil (not to be confused with palm oil).

Otherwise, N-Dodecanoic acid is relatively uncommon.
N-Dodecanoic acid is also found in human breast milk (6.2% of total fat), cow's milk (2.9%), and goat's milk (3.1%).

In various plants:
*The palm tree Attalea speciosa, a species popularly known in Brazil as babassu – 50% in babassu oil
*Attalea cohune, the cohune palm (also rain tree, American oil palm, corozo palm or manaca palm) – 46.5% in cohune oil
*Astrocaryum murumuru (Arecaceae) a palm native to the Amazon – 47.5% in "murumuru butter"
*Coconut oil 49%
*Pycnanthus kombo (African nutmeg)
*Virola surinamensis (wild nutmeg) 7.8–11.5%
*Peach palm seed 10.4%
*Betel nut 9%
*Date palm seed 0.56–5.4%
*Macadamia nut 0.072–1.1%
*Plum 0.35–0.38%
*Watermelon seed 0.33%
*Viburnum opulus 0.24-0.33%
*Citrullus lanatus (egusi melon)
*Pumpkin flower 205 ppm, pumpkin seed 472 ppm
*Insect
*Black soldier fly Hermetia illucens 30–50 mg/100 mg fat.



ALTERNATIVE PARENTS OF N-DODECANOIC ACID:
*Dicarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds



SUBSTITUENTS OF N-DODECANOIC ACID:
*Medium-chain fatty acid
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound



COMPOUND TYPE OF N-DODECANOIC ACID:
*Animal Toxin
*Cosmetic Toxin
*Food Toxin
*Industrial/Workplace Toxin
*Metabolite
*Natural Compound
*Organic Compound
*Plasticizer



CHEMICAL PROPERTIES OF N-DODECANOIC ACID:
N-Dodecanoic acid is a colorless needle-like crystals.
N-Dodecanoic acid is soluble in methanol, slightly soluble in acetone and petroleum ether.



STABILITY AND STORAGE CONDITIONS OF N-DODECANOIC ACID:
N-Dodecanoic acid is stable at normal temperatures and should be stored in a cool, dry place.



SOURCE AND PREPARATION OF N-DODECANOIC ACID:
N-Dodecanoic acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of N-Dodecanoic acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.



OCCURRENCE OF N-DODECANOIC ACID:
N-Dodecanoic acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil (not to be confused with palm oil).
Otherwise N-Dodecanoic acid is relatively uncommon.
N-Dodecanoic acid is also found in human breast milk ( 6.2 % of total fat), cow's milk (2.9%), and goat's milk (3.1 %).



SAFETY OF N-DODECANOIC ACID:
N-Dodecanoic acid is widely used in cosmetic preparations, in the manufacture of food-grade additives, and in pharmaceutical formulations.
General exposure to N-Dodecanoic acid occurs through the consumption of food and through dermal contact with cosmetics, soaps, and detergent products.

Occupational exposure may cause local irritation of eyes, nose, throat, and respiratory tract, although N-Dodecanoic acid is considered safe and nonirritating for use in cosmetics.
No toxicological effects were observed when N-Dodecanoic acid was administered to rats at 35% of the diet for 2 years.



MEDIUM-CHAIN TRIGLYCERIDES OF N-DODECANOIC ACID:
Medium-chain triglycerides, or fatty acids, such as N-Dodecanoic acid, are characterized by a specific chemical structure that allows your body to absorb them whole.

This makes them more easily digestible--your body processes them as it would carbohydrates, and they are used as a source of direct energy.
Compared to long-chain triglycerides, the type in other saturated fats, MCTs have fewer calories per serving, roughly 8.3 calories per gram rather than the standard 9 calories per gram, according to an article in "Nutrition Review."



NUTRITIONAL AND MEDICAL ASPECTS OF N-DODECANOIC ACID:
Although 95% of medium-chain triglycerides are absorbed through the portal vein, only 25–30% of N-Dodecanoic acid is absorbed through it.
N-Dodecanoic acid induces apoptosis in cancer and promotes the proliferation of normal cells by maintaining cellular redox homeostasis.
N-Dodecanoic acid increases total serum lipoproteins more than many other fatty acids, but mostly high-density lipoprotein (HDL).

As a result, N-Dodecanoic acid has been characterized as having "a more favorable effect on total HDL than any other fatty acid [examined], either saturated or unsaturated".
In general, a lower total/HDL serum lipoprotein ratio correlates with a decrease in atherosclerotic incidence.

Nonetheless, an extensive meta-analysis on foods affecting the total LDL/serum lipoprotein ratio found in 2003 that the net effects of N-Dodecanoic acid on coronary artery disease outcomes remained uncertain.
A 2016 review of coconut oil (which is nearly half N-Dodecanoic acid) was similarly inconclusive about the effects on cardiovascular disease incidence.



INCLUDING N-DODECANOIC ACID IN YOUR DIET:
N-Dodecanoic acid can be taken as a supplement, but it is most commonly consumed as part of coconut oil or palm kernel oil.
N-Dodecanoic acid is considered to be safe based on the amounts generally found in food.

According to NYU Langone Medical Center, coconut and palm kernel oil contain up to 15 percent MCTs, along with a number of other fats.
However, because they are still pure oil, limit your intake of MCTs to stay within the recommended 5 to 7 teaspoons of oil per day as set out by the U.S. Department of Agriculture.

You can use coconut and palm kernel oil for stir-fries because both oils withstand high heat.
They can also be used in baking, adding a natural richness to your food.



PHYSICAL PROPERTIES OF N-DODECANOIC ACID:
N-Dodecanoic acid occurs as a white crystalline powder with a slight odor of bay oil or a fatty odor.
N-Dodecanoic acid is a common constituent of most diets; large doses may produce gastrointestinal upset.



CHEMICAL PROPERTIES OF N-DODECANOIC ACID:
Like many other fatty acids, N-Dodecanoic acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.
N-Dodecanoic acid is mainly used for the production of soaps and cosmetics.

For these purposes, N-Dodecanoic acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil.
These precursors give mixtures of sodium laurate and other soaps.



PRODUCTION METHODS OF N-DODECANOIC ACID:
1. Industrial production methods can be grouped into two categories:
* derived from the saponification or high temperature and pressure decomposition of natural vegetable oils and fats;
* separated from the synthetic fatty acid.

Japan mainly uses coconut oil and palm kernel oil as the raw materials for the preparation of N-Dodecanoic acid.
The natural vegetable oils used to produce n-Dodecanoic acid include coconut oil, litsea cubeba kernel oil, palm kernel oil and mountain pepper seed oil.

Other plants oil, such as palm kernel oil, tea tree seed oil and camphor tree seed oil, can also service industry to produce n-Dodecanoic acid.
The residual C12 distillate from the extraction of N-Dodecanoic acid, containing a large number of dodecenoic acid, can be hydrogenated at atmospheric pressure, without catalyst, to convert into n-Dodecanoic acid with a yield of more than 86%.

2. Derived from the separation and purification of coconut oil and other vegetable oil.

3. N-Dodecanoic acid naturally exists in coconut oil, litsea cubeba kernel oil, palm kernel oil and pepper kernel oil in the form of glyceride.
N-Dodecanoic acid can be derived from the hydrolysis of natural oils and fats in industry.
The coconut oil, water and catalyst are added into the autoclave and hydrolyzed to glycerol and fatty acid at 250 ℃ under the pressure of 5MPa.
The content of n-Dodecanoic acid is 45%~80%, and can be further distilled to obtain n-Dodecanoic acid.



AIR AND WATER REACTIONS OF N-DODECANOIC ACID:
N-Dodecanoic acid is insoluble in water.



AROMA THRESHOLD VALUES OF N-DODECANOIC ACID:
Aroma threshold values
Aroma characteristics at 1.0%: fatty, creamy, cheeselike, candle waxy with egglike richness



TASTE THRESHOLD VALUES OF N-DODECANOIC ACID:
Taste characteristics at 5 ppm: waxy,fatty and oily, tallowlike, creamy and dairylike with a coating mouthfeel



REACTIVITY PROFILE OF N-DODECANOIC ACID:
N-Dodecanoic acid is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.

Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in N-Dodecanoic acid to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.



PRODUCTION METHODS OF N-DODECANOIC ACID:
N-Dodecanoic acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of N-Dodecanoic acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.



PHYSICAL and CHEMICAL PROPERTIES of n-DODECANOIC ACID:
Chemical formula: C10H18O4
Molar mass: 202.250 g•mol−1
Density: 1.209 g/cm3
Melting point: 131 to 134.5 °C (267.8 to 274.1 °F; 404.1 to 407.6 K)
Boiling point: 294.4 °C (561.9 °F; 567.5 K) at 100 mmHg
Solubility in water: 0.25 g/L
Acidity (pKa): 4.720, 5.450
Molecular Weight: 202.25
XLogP3: 2.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4

Rotatable Bond Count: 9
Exact Mass: 202.12050905
Monoisotopic Mass: 202.12050905
Topological Polar Surface Area: 74.6 Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 157
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: powder
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 133 - 137 °C - lit.
Initial boiling point and boiling range: 294,5 °C at 133 hPa - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available

Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0,224 g/l at 20 °C - OECD Test Guideline 105
Partition coefficient:
n-octanol/water: log Pow: 1,5 at 23 °C
Vapor pressure: 1 hPa at 183 °C
Density: 1,210 g/cm3 at 20 °C

Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Water Solubility: 0.91 g/L
logP: 1.93
logP: 2.27
logS: -2.4
pKa (Strongest Acidic): 4.72

Physiological Charge: -2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 2
Polar Surface Area: 74.6 Ų
Rotatable Bond Count: 9
Refractivity: 51.14 m³•mol⁻¹
Polarizability: 22.61 ų
Number of Rings: 0
Bioavailability: Yes
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: No
MDDR-like Rule: No

Melting point: 133-137 °C (lit.)
Boiling point: 294.5 °C/100 mmHg (lit.)
Density: 1.21
vapor pressure: 1 mm Hg ( 183 °C)
refractive index: 1.422
Flash point: 220 °C
storage temp.: Store below +30°C.
solubility: ethanol: 100 mg/mL
form: Powder or Granules
pka: 4.59, 5.59(at 25℃)
color: White to off-white
Water Solubility: 1 g/L (20 ºC)
Merck: 14,8415

BRN: 1210591
Stability: Stable.
LogP: 1.5 at 23℃
Appearance: white granular powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 130.80 °C. @ 760.00 mm Hg
Boiling Point: 364.00 to 365.00 °C. @ 760.00 mm Hg
Boiling Point: 235.00 to 234.00 °C. @ 10.00 mm Hg
Flash Point: 389.00 °F. TCC ( 198.30 °C. ) (est)
logP (o/w): 1.706 (est)
Soluble in: water, 1000 mg/L @ 20 °C (exp)
water, 1420 mg/L @ 25 °C (est)

Chemical formula: C12H24O2
Molar mass: 200.322 g•mol−1
Appearance: White powder
Odor: Slight odor of bay oil
Density: 1.007 g/cm³ (24 °C),
0.8744 g/cm³ (41.5 °C),
0.8679 g/cm³ (50 °C)
Melting point: 43.8 °C (110.8 °F; 316.9 K)
Boiling point: 297.9 °C (568.2 °F; 571.0 K),
282.5 °C (540.5 °F; 555.6 K) at 512 mmHg,
225.1 °C (437.2 °F; 498.2 K) at 100 mmHg
Solubility in water: 37 mg/L (0 °C), 55 mg/L (20 °C),
63 mg/L (30 °C), 72 mg/L (45 °C), 83 mg/L (100 °C)

Solubility: Soluble in alcohols, diethyl ether,
phenyls, haloalkanes, acetates
Solubility in methanol: 12.7 g/100 g (0 °C),
120 g/100 g (20 °C), 2250 g/100 g (40 °C)
Solubility in acetone: 8.95 g/100 g (0 °C),
60.5 g/100 g (20 °C), 1590 g/100 g (40 °C)
Solubility in ethyl acetate: 9.4 g/100 g (0 °C),
52 g/100 g (20°C), 1250 g/100 g (40°C)
Solubility in toluene: 15.3 g/100 g (0 °C),
97 g/100 g (20°C), 1410 g/100 g (40°C)
log P: 4.6

Vapor pressure: 2.13•10−6 kPa (25 °C),
0.42 kPa (150 °C),
6.67 kPa (210 °C)
Acidity (pKa): 5.3 (20 °C)
Thermal conductivity: 0.442 W/m•K (solid),
0.1921 W/m•K (72.5 °C),
0.1748 W/m•K (106 °C)
Refractive index (nD): 1.423 (70 °C),
1.4183 (82 °C)
Viscosity: 6.88 cP (50 °C), 5.37 cP (60 °C)
Structure:
Crystal structure: Monoclinic (α-form),
Triclinic, aP228 (γ-form)

Space group: P21/a, No. 14 (α-form), P1, No. 2 (γ-form)
Point group: 2/m (α-form)[8], 1 (γ-form)[9]
Lattice constant: a = 9.524 Å, b = 4.965 Å,
c = 35.39 Å (α-form),
α = 90°, β = 129.22°, γ = 90°
Thermochemistry:
Heat capacity (C): 404.28 J/mol•K
Std enthalpy of formation (ΔfH⦵298): −775.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298): 7377 kJ/mol,
7425.8 kJ/mol (292 K)
Molecular Weight: 200.32 g/mol
XLogP3: 4.2
Hydrogen Bond Donor Count: 1

Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 10
Exact Mass: 200.177630004 g/mol
Monoisotopic Mass: 200.177630004 g/mol
Topological Polar Surface Area: 37.3Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 132
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
IUPAC Name: dodecanoic acid
Traditional IUPAC Name: lauric acid
Formula: C12H24O2
InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChI Key: POULHZVOKOAJMA-UHFFFAOYSA-N
Molecular weight: 200.3178
Exact mass: 200.177630012
SMILES: CCCCCCCCCCCC(O)=O

Chemical Formula: C12H24O2
Average Molecular Weight: 200.3178
Monoisotopic Molecular Weight: 200.177630012
IUPAC Name: dodecanoic acid
Traditional Name: lauric acid
CAS Registry Number: 143-07-7
SMILES: CCCCCCCCCCCC(O)=O
InChI Identifier: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChI Key: POULHZVOKOAJMA-UHFFFAOYSA-N
Synonyms: n-Dodecanoic acid
IUPAC Name: Dodecanoic acid
Canonical SMILES: CCCCCCCCCCCC(=O)O
InChI: POULHZVOKOAJMA-UHFFFAOYSA-N

InChI Key: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
Boiling Point: 225 °C 100mmHg(lit.)
Melting Point: 44-46 °C(lit.)
Flash Point: 156ºC
Density: 0.883g/ml
Appearance: Clear liquid
Storage: Room temperature
CNo.Chain: C12:0
Compound Derivative: Acid
EC Number: 205-582-1
Fatty Acid: Dodecanoic (Lauric)
Hazard Codes: Xi

Hazard Statements: Xi
HS Code: 2916399090
LogP: 3.99190
MDL Number: MFCD00002736
Physical State: Solid
PSA: 37.3
Refractive Index: 1.4304
Safety Description: 37/39-26-39-36
Stability: Stable.
Incompatible with bases, oxidizing agents, reducing agents.
Storage Conditions: Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances.

Supplemental Hazard Statements: H401-H318-H319
Symbol: GHS05, GHS07
Vapor Pressure: 1 mm Hg ( 121 °C)
Formula: C12H24O2
InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
Molecular Weight: 200.322 g/mol
SMILES: OC(CCCCCCCCCCC)=O
SPLASH: splash10-0706-9000000000-b974e08e305014657f85
Source of Spectrum: HE-1982-0-0
CB Number: CB0357278
Molecular Formula: C12H24O2
Lewis structure
Molecular Weight: 200.32

MDL Number: MFCD00002736
MOL File: 143-07-7.mol
Melting point: 44-46 °C (lit.)
Boiling point: 225 °C/100 mmHg (lit.)
Density: 0.883 g/mL at 25 °C (lit.)
Vapor pressure: 1 mm Hg (121 °C)
Refractive index: 1.4304
FEMA: 2614 | LAURIC ACID
Flash point: >230 °F
Storage temp.: 2-8°C
Solubility: 4.81 mg/L
Form: Crystalline Powder of Flakes
pKa: 4.92 (H2O, t =25.0) (Uncertain)
Specific Gravity: 0.883
Color: White

Odor: at 100.00 % mild fatty coconut bay oil
Odor Type: fatty
Explosive limit: 0.6% (V)
Water Solubility: insoluble
λmax: 207 nm (MeOH) (lit.)
JECFA Number: 111
Merck: 14,5384
BRN: 1099477
Stability: Stable.
Incompatible with bases, oxidizing agents, reducing agents.
InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
LogP: 5

Dissociation constant: 5.3 at 20°C
Substances Added to Food (formerly EAFUS): LAURIC ACID
CAS DataBase Reference: 143-07-7 (CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 1160N9NU9U
NIST Chemistry Reference: Dodecanoic acid (143-07-7)
EPA Substance Registry System: Lauric acid (143-07-7)
Molecular Weight: 200.32
Exact Mass: 200.32
BRN: 1099477
EC Number: 205-582-1
HS Code: 29159010

Characteristics
PSA: 37.3
XLogP3: 4.2
Appearance: White Crystalline Powder of Flakes
Density: 0.883 g/cm³ @ Temp: 20 °C
Melting Point: 44.2 °C
Boiling Point: 298.9 °C
Flash Point: >230 °F
Refractive Index: 1.4304
Water Solubility: H2O: insoluble
Storage Conditions: Store below +30°C
Vapor Pressure: 1 mm Hg (121 °C)
Toxicity: LD50 i.v. in mice: 131 ±5.7 mg/kg (Or, Wretlind)
Explosive limit: 0.6% (V)
Odor: Characteristic, like oil of bay
pKa: 5.3 (at 20 °C)



FIRST AID MEASURES of n-DODECANOIC ACID:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of n-DODECANOIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of n-DODECANOIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of n-DODECANOIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of n-DODECANOIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry



STABILITY and REACTIVITY of n-DODECANOIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Conditions to avoid:
no information available

N-Dodecyl Mercaptan N-Dodecyl mercaptan (DDT) is an alkyl thiol that forms a self-assembled monolayer (SAM) and can be used as an organic source of sulfur with balanced physio-chemical properties. NDM (NORMAL DODECYL MERCAPTAN) is commonly used in the manufacturing process of polymers such as styrenics and acrylics (PMMA, ABS...). Application N-Dodecyl mercaptan can be used as a source of sulfur for the synthesis CdS quantum dots (QDs) and lead sulfide nanoparticles (PbS) which find potential applications in energy efficient lighting, solar cells and as ammonium gas sensing agents. N-Dodecyl mercaptan may be used to form a self-assembled monolayer (SAM) on copper surface as a corrosion resistant coating. Functionalization with N-Dodecyl mercaptan may form SAMs on geranium (Ge) to improve the surface characteristics for futuristic applications in microelectronics. This molecule is used for the production of hydrophobic SAMs. N-Dodecyl mercaptan can also be used in mixed SAMs to give a hydrophobic background and act as a spacer to move other functional groups or domains farther apart. Polymers and Rubber Applications Normal dodecyl mercaptan (n-dodecyl mercaptan, 1-dodecanethiol, lauryl mercaptan, NDDM, CAS # 112-55-0) is used as reactants in the synthesis of antioxidants, which minimize undesirable effects from processes such as the stabilization of tin. Applications Additives Antioxidants Lubricants Polymers N-Dodecyl mercaptan is not soluble in water, slightly soluble in light alcohols and soluble in styrene and most organic solvents. N-Dodecyl Mercaptan is used in lubricant intermediate to produce additives and final components. At the same time is it also used for polymers and rubber applications. N-Dodecyl Mercaptan is used in lubricant intermediates to produce additives as well as final components to improve lubricant performance in base oils and metal working fluids. Moreover Normal Dodecyl Mercaptan ( 1-dodecanethiol, lauryl mercaptan, NDDM) is used as reactants in the synthesis of antioxidants, which minimize undesirable effects from processes such as the stabilization of tin. Product Specifications Physical state : Liquid Color : Colorless Odor : Repulsive Flash point : 133 °C Oxidizing properties : no Autoignition temperature : 230 °C Molecular formula : C12H26S Molecular weight : 202,44 g/mol pH : Not applicable Boiling point/boiling range : 270 °C Vapor pressure : 0,00 mbar at 25 °C Water solubility : 0,0054 mg/l Method: OECD Test Guideline 105 Viscosity, dynamic : 2,98 cP at 25 °C Relative vapor density : 1 (Air = 1.0) Primary Chemistry: N-DODECYL MERCAPTAN Applications Lubricant Additive, Pharmaceutical Additives, Antioxidant Intermediates, Polymer Modifiers N-dodecyl mercaptan is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438). Teratogenicity was evaluated in pregnant female Charles River CD-1 mice (25/group) exposed by inhalation to n-dodecyl mercaptan at concentrations of 0 and 7.4 ppm for 6 hrs/day on gestation days (GD) 6-16. Cesarean sections were performed on all surviving mice on GD 17. Significant differences were observed between treated and control animals in the following: maternal mortality (19 mice died on GD 13-16, one was sacrificed in extremis on GD 16, remaining mice, which exhibited signs of extreme toxicity, were sacrificed on GD 15-16), necropsy observations (including black discoloration of the intestines, colored fluid in the stomach or intestines, and absence of stomach contents), and incidence of whole litter resorptions (7 of 20 gravid females). Since no treated animals survived to the end of the study, no comparisons between treated and control animals can be made with respect to: maternal body weight and weight gain (weight loss was observed in treated animals), GD 17 Cesarean observations, and fetal morphological examination (since the fetuses were obtained prematurely, the skeletons were partially- or non-ossified). Teratogenicity was evaluated in pregnant female Charles River COBS CD rats (25/group) exposed by inhalation to n-dodecyl mercaptan at concentrations of 0 and 7.4 ppm for 6 hrs/day on gestation days (GD) 6-19. Cesarean sections were performed on all surviving mice on GD 20. Significant differences were observed between treated and control animals in the following: increased incidence of hair loss, reddened conjunctivae, dry brown or black material around the nose, dry, peeling skin, thinness, and a pronounced reduction in maternal body weight gain. No significant differences were observed between treated and control animals in the following: necropsy examination, mean number of viable fetuses, postimplantation loss, total implantations, corpora lutea, fetal body weight, fetal sex ratio, fetal malformations, and genetic and developmental variations. Environmental Fate/Exposure Summary N-dodecyl mercaptan's production and use in pharmaceuticals, insecticides, nonionic detergents, synthetic rubber processing, and as a froth flotation agent for metal refining may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 8.53X10-3 mm Hg at 25 °C indicates N-dodecyl mercaptan will exist solely as a vapor in the ambient atmosphere. Vapor-phase N-dodecyl mercaptan will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 7 hours. N-dodecyl mercaptan does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, N-dodecyl mercaptan is expected to be immobile based upon an estimated Koc of 1.1X10+4. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. Biodegradation data were not available. If released into water, N-dodecyl mercaptan is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 4 hours and 6 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered. An estimated BCF of 360 suggests the potential for bioconcentration in aquatic organisms is moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to N-dodecyl mercaptan may occur through inhalation and dermal contact with this compound at workplaces where N-dodecyl mercaptan is produced or used. The greatest potential for dermal and inhalation exposure to N-dodecyl mercaptan is expected at the packing station at the manufacturing site and to a lesser extent during activities at the consumer site. N-dodecyl mercaptan's production and use in pharmaceuticals, insecticides, nonionic detergents, synthetic rubber processing, and as a froth flotation agent for metal refining(1) may result in its release to the environment through various waste streams(SRC). TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.1X10+4(SRC), determined from a structure estimation method(2), indicates that N-dodecyl mercaptan is expected to be immobile in soil(SRC). Volatilization of N-dodecyl mercaptan from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, adsorption to soil is expected to attenuate volatilization(SRC). N-dodecyl mercaptan is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.53X10-3 mm Hg(4). Biodegradation data were not available(SRC, 2005). AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.1X10+4(SRC), determined from a structure estimation method(2), indicates that N-dodecyl mercaptan is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 6 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 360(SRC), from an estimated log Kow of 6.2(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate (SRC). Biodegradation data were not available(SRC, 2005). ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-dodecyl mercaptan, which has a vapor pressure of 8.53X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-dodecyl mercaptan is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 hours(SRC), calculated from its rate constant of 5.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). N-dodecyl mercaptan does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). The rate constant for the vapor-phase reaction of N-dodecyl mercaptan with photochemically-produced hydroxyl radicals has been estimated as 5.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A half-life of 100 days was reported for N-dodecyl mercaptan reaction with ozone(2). N-dodecyl mercaptan is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3). N-dodecyl mercaptan does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). An estimated BCF of 360 was calculated for N-dodecyl mercaptan(SRC), using an estimated log Kow of 6.18(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC). Using a structure estimation method based on molecular connectivity indices(1), the Koc of N-dodecyl mercaptan can be estimated to be 1.1X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that N-dodecyl mercaptan is expected to be immobile in soil. The Henry's Law constant for N-dodecyl mercaptan is estimated as 5.9X10-2 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that N-dodecyl mercaptan is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered(3). N-dodecyl mercaptan's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC); however, the compound is reported as having extremely low volatility(4). N-dodecyl mercaptan is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.53X10-3 mm Hg(5). SEDIMENT: N-dodecyl mercaptan was detected from sites adjacent to the 102nd St. Dump site, Bloody Run Creek, and Gill Creek hazardous waste disposal areas in Niagara Falls, NY at concentrations of 3 ppm, not detected (detection limit = 0.5 ppm in sediment), and not detected, respectively, sampled in June and November, 1979(1). The dumps are in the vicinity of Love Canal(1). NIOSH (NOES Survey 1981-1983) has statistically estimated that 92,230 workers (17,777 of these are female) are potentially exposed to N-dodecyl mercaptan in the US(1). Occupational exposure to N-dodecyl mercaptan may occur through inhalation and dermal contact with this compound at workplaces where N-dodecyl mercaptan is produced or used(SRC). The greatest potential for dermal and inhalation exposure to N-dodecyl mercaptan is expected at the packing station at the manufacturing site and to a lesser extent during activities at the consumer site(SRC). Applications of N-dodecyl mercaptan N-dodecyl mercaptan is used in the preparation of hydrophobic or mixed self-assembled monolayers. N-dodecyl mercaptan is also employed as a chain transfer agent for radical polymerization. Further, it is utilized as a polymerization inhibitor in polyurethane and neoprene adhesives, which finds application in the footwear industry. In addition to this, it acts as a protein regenerating agent used for the regeneration of native proteins from mercuribenzoate. Solubility of N-dodecyl mercaptan Immiscible with water. Notes Air and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with bases, oxidizing agents, reducing agents and alkali metals. n-Dodecyl mercaptan transfer constant in polymerization of methyl methacrylate This paper investigates the effect of n-dodecyl mercaptan (n-DDM) as a chain transfer agent on the molecular weight of poly(methyl methacrylate). The transfer constant of n-Dodecyl mercaptan was calculated at different temperatures; the activation energy and frequency factor for an Arrhenius equation of transfer constant were then obtained. Kinetics of the styrene emulsion polymerization using n‐dodecyl mercaptan as chain‐transfer agent The kinetics of the styrene emulsion polymerization using n‐dodecyl mercaptan as chain‐transfer agent was studied. n‐dodecyl mercaptan was found that the chain‐transfer agent (CTA) had no effect on polymerization rate but substantially affected the molecular weight distribution (MWD). The efficiency of the CTA in reducing the MWD was lowered by the mass‐transfer limitations. The process variables affecting CTA mass transfer were investigated. A mathematical model for the process was developed. The outputs of the model include monomer conversion, particle diameter, number of polymer particles, and number‐average and weight‐average molecular weights. The model was validated by fitting the experimental data. Polymerization of methyl methacrylate by 2‐pyrrolidinone and n‐dodecyl mercaptan The bulk polymerization of methyl methacrylate initiated with 2‐pyrrolidinone and n‐dodecyl mercaptan (R‐SH) has been explored. This polymerization system showed “living” characteristics; for example, the molecular weight of the resulting polymers increased with reaction time by gel permeation chromatographic analysis. Also, the polymer was characterized by Fourier transform infrared spectroscopy, 1H NMR, and 13C NMR techniques. The polymer end with the iniferter structures was found. By the initial‐rate method, the polymerization rate depended on [2‐pyrrolidinone]1.0 and [R‐SH]0. Combining the structure analysis and the polymerization‐rate expression, a possible mechanism was proposed. n‐Dodecyl mercaptan served dual roles—as a catalyst at low conversion and as a chain‐transfer agent at high conversion. Finally, the thermal properties were studied, and the glass‐transition temperature and thermal‐degradation temperature were, respectively, 25 and 80–100 °C higher than that of the azobisisobutyronitrile system. General description of N-dodecyl mercaptan 1-Dodecanethiol (DDT) is an alkyl thiol that forms a self-assembled monolayer (SAM) and can be used as an organic source of sulfur with balanced physio-chemical properties.[2] Application of N-dodecyl mercaptan N-dodecyl mercaptan (DDT) can be used as a source of sulfur for the synthesis CdS quantum dots (QDs) and lead sulfide nanoparticles (PbS) which find potential applications in energy efficient lighting, solar cells and as ammonium gas sensing agents. N-dodecyl mercaptan may be used to form a self-assembled monolayer (SAM) on copper surface as a corrosion resistant coating. [6]Functionalization with DDT may form SAMs on geranium (Ge) to improve the surface characteristics for futuristic applications in microelectronics.[7] This molecule is used for the production of hydrophobic SAMs. N-dodecyl mercaptan can also be used in mixed SAMs to give a hydrophobic background and act as a spacer to move other functional groups or domains farther apart. Polymers and Rubber Applications Normal dodecyl mercaptan (n-dodecyl mercaptan, 1-dodecanethiol, lauryl mercaptan, NDDM, CAS # 112-55-0) is used as reactants in the synthesis of antioxidants, which minimize undesirable effects from processes such as the stabilization of tin. Applications Additives Antioxidants Lubricants Polymers n-Dodecyl mercaptan's production and use in pharmaceuticals, insecticides, nonionic detergents, synthetic rubber processing, and as a froth flotation agent for metal refining may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 8.53X10-3 mm Hg at 25 °C indicates n-Dodecyl mercaptan will exist solely as a vapor in the ambient atmosphere. Vapor-phase n-Dodecyl mercaptan will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 7 hours. n-Dodecyl mercaptan does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, n-Dodecyl mercaptan is expected to be immobile based upon an estimated Koc of 1.1X10+4. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. Biodegradation data were not available. If released into water, n-Dodecyl mercaptan is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 4 hours and 6 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered. An estimated BCF of 360 suggests the potential for bioconcentration in aquatic organisms is moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to n-Dodecyl mercaptan may occur through inhalation and dermal contact with this compound at workplaces where n-Dodecyl mercaptan is produced or used. The greatest potential for dermal and inhalation exposure to n-Dodecyl mercaptan is expected at the packing station at the manufacturing site and to a lesser extent during activities at the consumer site. n-Dodecyl mercaptan's production and use in pharmaceuticals, insecticides, nonionic detergents, synthetic rubber processing, and as a froth flotation agent for metal refining(1) may result in its release to the environment through various waste streams(SRC). Based on a classification scheme(1), an estimated Koc value of 1.1X10+4(SRC), determined from a structure estimation method(2), indicates that n-Dodecyl mercaptan is expected to be immobile in soil(SRC). Volatilization of n-Dodecyl mercaptan from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, adsorption to soil is expected to attenuate volatilization(SRC). n-Dodecyl mercaptan is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.53X10-3 mm Hg(4). Biodegradation data were not available(SRC, 2005). According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-Dodecyl mercaptan, which has a vapor pressure of 8.53X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase n-Dodecyl mercaptan is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 hours(SRC), calculated from its rate constant of 5.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). n-Dodecyl mercaptan does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). The rate constant for the vapor-phase reaction of n-Dodecyl mercaptan with photochemically-produced hydroxyl radicals has been estimated as 5.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A half-life of 100 days was reported for n-Dodecyl mercaptan reaction with ozone(2). n-Dodecyl mercaptan is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3). n-Dodecyl mercaptan does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). The Henry's Law constant for n-Dodecyl mercaptan is estimated as 5.9X10-2 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that n-Dodecyl mercaptan is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered(3). n-Dodecyl mercaptan's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC); however, the compound is reported as having extremely low volatility(4). n-Dodecyl mercaptan is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.53X10-3 mm Hg(5). NIOSH (NOES Survey 1981-1983) has statistically estimated that 92,230 workers (17,777 of these are female) are potentially exposed to n-Dodecyl mercaptan in the US(1). Occupational exposure to n-Dodecyl mercaptan may occur through inhalation and dermal contact with this compound at workplaces where n-Dodecyl mercaptan is produced or used(SRC). The greatest potential for dermal and inhalation exposure to n-Dodecyl mercaptan is expected at the packing station at the manufacturing site and to a lesser extent during activities at the consumer site(SRC). N-Dodecyl Mercaptan is used in lubricant intermediates to produce additives as well as final components to improve lubricant performance in base oils and metal working fluids. Moreover Normal Dodecyl Mercaptan ( 1-dodecanethiol, lauryl mercaptan, NDDM) is used as reactants in the synthesis of antioxidants, which minimize undesirable effects from processes such as the stabilization of tin. n-Dodecyl mercaptan transfer constant in polymerization of methyl methacrylate This paper investigates the effect of n-dodecyl mercaptan (n-DDM) as a chain transfer agent on the molecular weight of poly(methyl methacrylate). The transfer constant of n-Dodecyl mercaptan was calculated at different temperatures; the activation energy and frequency factor for an Arrhenius equation of transfer constant were then obtained. Kinetics of the styrene emulsion polymerization using n‐dodecyl mercaptan as chain‐transfer agent The kinetics of the styrene emulsion polymerization using n‐dodecyl mercaptan as chain‐transfer agent was studied. n‐dodecyl mercaptan was found that the chain‐transfer agent (CTA) had no effect on polymerization rate but substantially affected the molecular weight distribution (MWD). The efficiency of the CTA in reducing the MWD was lowered by the mass‐transfer limitations. The process variables affecting CTA mass transfer were investigated. A mathematical model for the process was developed. The outputs of the model include monomer conversion, particle diameter, number of polymer particles, and number‐average and weight‐average molecular weights. The model was validated by fitting the experimental data. N-Dodecyl mercaptan is not soluble in water, slightly soluble in light alcohols and soluble in styrene and most organic solvents. N-Dodecyl Mercaptan is used in lubricant intermediate to produce additives and final components. At the same time is it also used for polymers and rubber applications. N-Dodecyl Mercaptan is used in lubricant intermediates to produce additives as well as final components to improve lubricant performance in base oils and metal working fluids. Moreover Normal Dodecyl Mercaptan ( 1-dodecanethiol, lauryl mercaptan, NDDM) is used as reactants in the synthesis of antioxidants, which minimize undesirable effects from processes such as the stabilization of tin.

2,2-Dimethyl-1,3-propanediol; Dimethylolpropane; 2,2-dimethylpropane-1,3-diol; 2,2-Dimethyltrimethylene glycol; Neopentanediol; Neopentylene glycol; Dimethyltrimethylene glycol; Hydroxypivalyl alcohol; 1,3-Dihydroxy-2,2-dimethylpropane; 2,2-Dimethyl-1,3-dihydroxypropane; NPG; cas no: 126-30-7

Neo Heliopan 303 is a safe and effective UVB absorber.
Neo Heliopan 303 acts as an effective oil-soluble and liquid UVB absorber.


CAS Number: 6197-30-4
EC Number: 228-250-8
INCI name: Octocrylene
USAN: Octocrylene
Chemical names: 2-Ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate
2-Ethylhexyl-2-cyano-3,3-diphenyl acrylate
CAS Name: 2-Cyano-3,3-diphenyl-2-propenoic acid 2-ethylhexyl ester
Chemical Composition: 2-Ethylhexyl 2-cyano-3,3-diphenyl acrylate
Empirical Formula: C24H27NO2



SYNONYMS:
2-Ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate, Octocrylene, Octocrilene, Uvinul N-539,



Neo Heliopan 303 is an organic compound used as an ingredient in sunscreens and cosmetics.
Neo Heliopan 303 is an ester formed by the Knoevenagel condensation of 2-ethylhexyl cyanoacetate with benzophenone.
Neo Heliopan 303 is a viscous, oily liquid that is clear and colorless.


Neo Heliopan 303 is approved world-wide.
Concentration maximum varies according to local legislation
Neo Heliopan 303 is a safe and effective UVB absorber.


Neo Heliopan 303 acts as an effective oil-soluble and liquid UVB absorber.
Neo Heliopan 303 provides UV protection for a wide variety of cosmetic applications.
Neo Heliopan 303 offers additional absorption in the short-wave UVA spectrum.


Neo Heliopan 303 acts as a very good solubilizer for crystalline UV absorbers.
Neo Heliopan 303 is suitable for the formulation of water-resistant sunscreen products.
Neo Heliopan 303 is an effective oil soluble and liquid UVB absorber offering additional absorption in the short-wave UVA spectrum.


Neo Heliopan 303 is an excellent solubilizer for crystalline UV absorbers.
Neo Heliopan 303 is a condition at 20°C clear, light yellow to yellow viscous liquid
Neo Heliopan 303 has faint odor (comparable to standard)


Neo Heliopan 303 is oil-soluble.
Neo Heliopan 303 is a effective liquid UVB absorber which shows significant protection in the shorter UVA-II range (320 to 340 nm).
Maximum absorption of Neo Heliopan 303 is at around 303 nm with an UV absorbance of min. 340.


Neo Heliopan 303 has excellent photostability.
Neo Heliopan 303 can improve the photostability of Butyl Methoxydibenzoylmethane.
Neo Heliopan 303 is suitable Vegan according to Symrise policy.


Neo Heliopan 303 is halal & Kosher status available on request.
Neo Heliopan 303 is a high-quality sunscreen that provides broad-spectrum protection against both UVA and UVB rays.
Neo Heliopan 303 is water-resistant and suitable for all skin types.
This sunscreen, Neo Heliopan 303, is formulated with advanced ingredients to help protect your skin from sun damage and premature aging.



USES and APPLICATIONS of NEO HELIOPAN 303:
Neo Heliopan 303 is used Sun care (Sun protection, After-sun & Self-tanning)>Sun protection.
Recommended use levels of Neo Heliopan 303: Approved world-wide. Concentration maximum varies according to local legislation.
Neo Heliopan 303 is used as an effective oil soluble and liquid UVB absorber for a wide variety of cosmetic applications.


Neo Heliopan 303 offers additional absorption in the short-wave UVA spectrum.
Neo Heliopan 303 possesses very good solubilizer for crystalline UV absorbers.
Neo Heliopan 303 is suitable for the formulation of water-resistant sunscreen products.


Uses of Neo Heliopan 303: Sun care (Sun protection, After-sun, Self-tanning).
Neo Heliopan 303 uses the extended conjugation of the acrylate portion of the molecule to absorb UVB and short-wave UVA (ultraviolet) rays with wavelengths from 280 to 320 nm, protecting the skin from direct DNA damage.


The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water resistant) properties.
Group of Neo Heliopan 303: Personal Care; Cosmetic Raw Materials; Sunscreen Actives.
Neo Heliopan 303 is used as an effective oil soluble and liquid UVB absorber for a wide variety of cosmetic applications.


Neo Heliopan 303 offers additional absorption in the short-wave UVA spectrum.
Neo Heliopan 303 possesses very good solubilizer for crystalline UV absorbers.
Neo Heliopan 303 is suitable for the formulation of water-resistant sunscreen products.


Neo Heliopan 303 is used as an effective oil soluble and liquid UVB absorber for a wide variety of cosmetic applications.
Neo Heliopan 303 offers additional absorption in the short-wave UVA spectrum.
Neo Heliopan 303 possesses very good solubilizer for crystalline UV absorbers.


Neo Heliopan 303 is suitable for the formulation of water-resistant sunscreen products.
Neo Heliopan 303 is used solvent for solid sunscreens. UV absorber for plastics and paints.



BENEFITS OF NEO HELIOPAN 303:
Neo Heliopan 303 is an effective oil soluble and liquid UVB absorber offering additional absorption in the short-wave UVA spectrum.
Maximum absorption of Neo Heliopan 303 is at 303nm

Neo Heliopan 303 is suitable for a wide variety of cosmetic applications
The oil soluble UVB filter is ideal for the formulation of water-resistant sunscreen products
Neo Heliopan 303 is an excellent solubilizer for crystalline UV absorbers



PROPERTIES OF NEO HELIOPAN 303:
Neo Heliopan 303 is a clear yellow viscous liquid, bp0.9 205-209°. fp -10°. d25 1.05. uv max: 303 nm.
Neo Heliopan 303 is miscible in methanol, n-butanol, ethyl acetate, mineral oil, hexane, toluene.
Neo Heliopan 303 is immiscible in water.



CLAIMS OF NEO HELIOPAN 303:
*Sunscreen Agents > UV Filters / Sunscreens protections
*UVB absorber



THE BENEFITS OF NEO HELIOPAN 303:
• Neo Heliopan 303 is an effective oil soluble and liquid UVB absorber which shows significant protection in the shorter UV-A II range (320 to 340 nm).
Maximum absorption of Neo Heliopan 303 is at around 303 nm with an UV absorbance (E 1% ) of min. 340.
• Neo Heliopan 303 has an excellent photostability itself and can improve the in vitro photostability of Butyl Methoxydibenzoylmethane.
• Neo Heliopan 303 is easily to incorporate into emulsions and suitable for a wide variety of cosmetic applications.
Cold processing of sunscreen products is possible.
• Neo Heliopan 303 is used in combination with other UV-B absorbers to formulate high SPF sunscreen products.
• The oil soluble UVB filter is ideal to formulate waterproof sunscreen products because of its
very high resistance to water wash-off.
• Neo Heliopan 303 is an excellent solvent for crystalline and oil-soluble UV absorbers and cosmetic ingredients.
• Approved world-wide.
Concentration maximum varies according to local legislation.
• Neo Heliopan 303 is a safe and effective UVB absorber.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN 303:
CAS No.: 6197-30-4
EINECS: 228-250-8
UV-B absorber: oil soluble
Molecular Weight: 361.5 g/mol
INCI name: Octocrylene
USAN: Octocrylene
Chemical names: 2-Ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate
2-Ethylhexyl-2-cyano-3,3-diphenyl acrylate
Empirical Formula: C24H27NO2
Assay (GLC) %: min. 98
Single impurity >0.5%: not detectable
Sum of impurities >2.0%: not detectable
Relative density (D25/25): 1.045 – 1.055
Relative density (D20/4): 1.046 – 1.056

Refractive Index (n20/D): 1.561 – 1.571
Specific extinction E 1% ,
in methanol λ max. 303 nm: 340 – 369
Solubility at 20°C in: Readily soluble in most cosmetic oils except mineral oil and glycols.
Shelf life and storage conditions: 36 months in the original, unopened container, dry, at 5 to 40°C.
Boiling point: bp0.9 205-209°
Absorption maximum: uv max: 303 nm
Density: d25 1.05
Chemical formula: C24H27NO2
Molar mass: 361.48 g/mol
Density: 1.05 g/cm3
Melting point: 14 °C (57 °F; 287 K)
Boiling point: 218 °C (424 °F; 491 K) at 1.5 mmHg



FIRST AID MEASURES of NEO HELIOPAN 303:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN 303:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN 303:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN 303:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN 303:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN 303:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan 357 is an organic molecule and an oil-soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays.
Neo Heliopan 357 is an oil-soluble substance used in sunscreen products to absorb the full spectrum of UVA rays.


CAS Number: 70356-09-1
EC Number: 274-581-6
MDL NO: MFCD22421631
UV-A absorber: oil soluble
INCI name: Butyl Methoxydibenzoylmethane
USAN: Avobenzone
Chemical Composition: 1-(4-Methoxyphenyl)-3-(4-tert.-butylphenyl)propan-1,3-dione
Chemical names: 1-(4-Methoxyphenyl)-3-(4-tert.-butyl phenyl)propan-1,3-dione
Empirical Formula: C20H22O3



SYNONYMS:
1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 3-(4-tert-Butylphenyl)-1-(4-methoxyphenyl)propane-1,3-dione, butylmethoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane,



Neo Heliopan 357 is a condition at 20°C white to pale yellow powder
Neo Heliopan 357 has weakly aromatic, no effect on finished product (comparable to standard)
Neo Heliopan 357 is a very effective UVA I absorber for a wide range of applications.


Neo Heliopan 357 is an oil soluble, crystalline powder.
Neo Heliopan 357 is an organic molecule and an oil-soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays.
Neo Heliopan 357 is an oil-soluble substance used in sunscreen products to absorb the full spectrum of UVA rays.


Neo Heliopan 357 is a dibenzoylmethane derivative.
Neo Heliopan 357 exists in its ground state as a mixture of enol and keto forms, favoring chelated enol.
This enol form is stabilized by intramolecular hydrogen-bonding within the β-diketone.


The ability to absorb ultraviolet light over a wider range of wavelengths than most other sunscreen agents has led to their use in many commercial preparations marketed as "broad spectrum" sunscreens.
Neo Heliopan 357 has an absorption maximum of 357nm.


Neo Heliopan 357 is an oil soluble ingredient used in sunscreens.
Neo Heliopan 357 has the ability to absorb ultraviolet light over a wider range of wavelengths and provide protection from the sun.



USES and APPLICATIONS of NEO HELIOPAN 357:
Neo Heliopan 357 acts as an effective UVA absorber.
Neo Heliopan 357 should be used in association with effective UVB absorbers to achieve formulations with broad-spectrum UV protection.
Neo Heliopan 357 is used in sun care formulations.


Neo Heliopan 357 is a synthetic ultraviolet absorber.
Neo Heliopan 357 is a good absorber of UV-A (>320nm) type ultraviolet, can block full band of uva (320~400nm), and is an efficient broad-spectrum oil-soluble UVA filter, compounded with other UVB sunscreens, can provide all UVA and UVB protection, photo-induced.


Neo Heliopan 357 is used to prevent skin cancer.
Neo Heliopan 357 acts as an effective UVA absorber for wide range of applications.
Neo Heliopan 357 should be used in association with effective UVB absorbers to achieve formulations with broad-spectrum protection.
Neo Heliopan 357 is used in sun care formulations



THE BENEFITS OF NEO HELIOPAN 357:
• The most important UV-A filter in the world.
• Highly effective with a maximum absorption at 357 nm with a specific extinction (E 1% ) of about 1100 and with
additional absorbing properties in the UVA II spectrum.
• Neo Heliopan 357 is an oil soluble, crystalline powder with a slight aromatic odor.
Adequate solubility in the formulation must be ensured in order to avoid recrystallization of the Neo Heliopan 357.
The UV filters Neo Heliopan AV, E1000, 303, OS, HMS and certain emollients are excellent solvents.
• Neo Heliopan 357 should be used in association with effective UVB absorbers to achieve formulations with
broad-spectrum protection.
• In combination with the water soluble UVA II absorber Neo Heliopan AP very broad spectrum UVA protection
products can be formulated
• Approved world-wide.
Concentration maximum varies according to local legislation.
• Neo Heliopan 357 is a safe and effective UVA absorber. Safety and efficacy studies are available on request.



CLAIMS OF NEO HELIOPAN 357:
*Sunscreen Agents > UV Filters / Sunscreens protections
*UVA Absorber



PROPERTIES OF NEO HELIOPAN 357:
Neo Heliopan 357 is a whitish to yellowish crystalline powder with a weak odor, dissolving in isopropanol, dimethyl sulfoxide, decyl oleate, capric acid/caprylic, triglycerides and other oils.
Neo Heliopan 357 is not soluble in water.

Neo Heliopan 357 is a dibenzoylmethane derivative.
Neo Heliopan 357 exists in the ground state as a mixture of the enol and keto forms, favoring the chelated enol.
This enol form is stabilized by intramolecular hydrogen-bonding within the β-diketone.

Neo Heliopan 357's ability to absorb ultraviolet light over a wider range of wavelengths than many other sunscreen agents has led to its use in many commercial preparations marketed as "broad spectrum" sunscreens.
Neo Heliopan 357 has an absorption maximum of 357 nm



VARIOUS OF NEO HELIOPAN 357:
As an enolate, Neo Heliopan 357 forms with heavy metal ions (such as Fe3+) colored complexes, and chelating agents can be added to suppress them.
Stearates, aluminum, magnesium and zinc salts can lead to poorly soluble precipitates.
Manufacturers also recommend to avoid the inclusion of iron and ferric salts, heavy metals, formaldehyde donors and PABA and PABA esters.

Neo Heliopan 357 in sunscreen may stain clothes yellow-orange and make them sticky if washed in iron-rich water, as it reacts with iron to produce rust.
The damage can be undone with a rust remover or stain remover
The staining properties of sunblock made with Neo Heliopan 357 are particularly noticeable on fiberglass boats with white gelcoat.



STABILITY OF NEO HELIOPAN 357:
Neo Heliopan 357 is sensitive to the properties of the solvent, being relatively stable in polar protic solvents and unstable in nonpolar environments.
Also, when Neo Heliopan 357 is irradiated with UVA light, it generates a triplet excited state in the keto form which can either cause the Neo Heliopan 357 to degrade or it can transfer energy to biological targets and cause deleterious effects.

Neo Heliopan 357 has been shown to degrade significantly in light, resulting in less protection over time.
The UV-A light in a day of sunlight in a temperate climate is sufficient to break down most of the compound.

Data presented to the Food and Drug Administration by the Cosmetic, Toiletry and Fragrance Association indicates a −36% change in Neo Heliopan 357's UV absorbance following one hour of exposure to sunlight.
For this reason, in sunscreen products, Neo Heliopan 357 is always formulated together with a photostabilizer, such as octocrylene.

Other photostabilizers include:
*Neo Heliopan 357 (USAN Enzacamene)
*Tinosorb S (USAN Bemotrizinol, INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine)
*Tinosorb M (USAN Bisoctrizole, INCI Methylene Bis-Benzotriazolyl Tetramethylbutylphenol)
*Butyloctyl Salicylate (Tradename HallBrite BHB)
*Hexadecyl Benzoate
*Butyloctyl Benzoate
*HallBrite PSF (INCI Undecylcrylene DimethiconeE)
*Mexoryl SX (USAN Ecamsule, INCI Terephthalylidene Dicamphor Sulfonic Acid)
*Synoxyl HSS (INCI Trimethoxybenzylidene Pentanedione)
*Corapan TQ (INCI Diethylhexyl 2,6-Naphthalate)
*Parsol SLX (INCI Polysilicone-15)
*Oxynex ST (INCI Diethylhexyl Syringylidene Malonate
*Polycrylene (INCI Polyester-8)
*SolaStay S1 (INCI Ethylhexyl Methoxycrylene)
*Octyl Salicylate (INCI Ethylhexyl Salicylate)

Complexing Neo Heliopan 357 with cyclodextrins may also increase its photostability.
Formulations of Neo Heliopan 357 with hydroxypropyl-beta-cyclodextrin have shown significant reduction in photo-induced degradation, as well as decreased transdermal penetration of the UV absorber when used in high concentrations.

The photostability of Neo Heliopan 357 is further increased when sunscreens are formulated with antioxidant compounds.
Mangiferin, glutathione, ubiquinone, vitamin C, vitamin E, beta-carotene and trans-resveratrol have all demonstrated some ability to protect Neo Heliopan 357 from photodegradation.

The stability and efficacy of Neo Heliopan 357 seems to continue to increase as a greater amount of antioxidants are added to the sunscreen.
According to some studies, "the most effective sunscreens contain Neo Heliopan 357 and titanium dioxide."

Neo Heliopan 357 can degrade faster in light in combination with mineral UV absorbers like zinc oxide and titanium dioxide, though with the right coating of the mineral particles this reaction can be reduced.
A manganese doped titanium dioxide may be better than undoped titanium dioxide to improve Neo Heliopan 357's stability

Neo Heliopan 357 also reacts with boron trifluoride to form a stable crystalline complex that is highly fluorescent under UV irradiation.
The emission color of the crystals depends on the molecular packing of the boron Neo Heliopan 357 complex.

The photoluminescence may also be altered by mechanical force in the solid state, resulting in a phenomenon called "mechanochromic luminescence".
The altered emission color recovers itself slowly at room temperature or more swiftly at higher temperatures.

Absorbance spectrum:
Neo Heliopan 357 has a peak absorbance around 360 nm when dissolved.
The peak may shift slightly depending on the solvent.



IMPORTANT ADVICE OF NEO HELIOPAN 357 FOR FORMULATIONS:
When formulating with Neo Heliopan 357 a chelating agent should be added to the oil phase of the emulsion to avoid the formation of colored complexes with free metal ions such as iron.
The use of formaldehyde doning preservative systems, or preservation systems with reactive methylene groups, should be avoided since these species react with Neo Heliopan 357 at temperatures above 30°C.

This results in loss of preservation in the formulation.
The combination of Neo Heliopan 357 and Zinc
Oxide can interact to form a complex which may precipitate out.

Neo Heliopan 303, Neo Heliopan BMT and
Corapan TQ (Diethylhexyl 2,6-Naphthalate) can
improve the photostability of Neo Heliopan 357.



HISTORY OF NEO HELIOPAN 357:
Neo Heliopan 357 was patented in 1973 and was approved in the EU in 1978.
Neo Heliopan 357 was approved by the FDA in 1988.
As of 2021, the FDA announced that they do not support Neo Heliopan 357 as being generally recognized as safe and effective (GRASE) citing the need for additional safety data.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN 357:
CAS No.: 70356-09-1
EINECS: 274-581-6
UV-A absorber: oil soluble
Molecular Weight: 310.4 g/mol
INCI name: Butyl Methoxydibenzoylmethane
USAN: Avobenzone
Chemical names: 1-(4-Methoxyphenyl)-3-(4-tert.-butyl phenyl)propan-1,3-dione
Empirical Formula: C20H22O3
Assay (GLC) %: 95.0 – 100.0
Single impurity >3.0%: not detectable
Sum of impurities >4.5%: not detectable

Loss on drying (USP)%: max. 0.5
Melting point °C: 81.0 – 86.0
Specific extinction E 1% ,
in methanol λ max. 357 nm: 1100.0 – 1210.0
Shelf life and storage conditions: 36 months in the original, unopened container, dry, at 5 to 40°C
CAS NO: 70356-09-1
Molecular Formula: C20H22O3
Molecular weight: 310.387
EINECS NO: 274-581-6
MDL NO: MFCD22421631



FIRST AID MEASURES of NEO HELIOPAN 357:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN 357:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN 357:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN 357:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN 357:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN 357:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan AP is a highly effective and photostable UVA II absorber.
Neo Heliopan AP is a highly effective UVA ii absorber with a UV absorbance.


CAS Number: 180898-37-7
EC Number: 429-750-0
UV-A absorber: water soluble
Molecular Weight: 674.59 g/mol
INCI name: Disodium Phenyl Dibenzimidazole Tetrasulfonate
Chemical names: 2,2’-(1,4-Phenylene) bis-[1H-benzimidazole-4, 6-disulfonic
acid], disodium salt
Chemical Composition: 2,2’-(1,4-Phenylene) bis-[1H-benzimidazole-4,6-disulfonic acid], disodium salt
Empirical Formula: C20H12N4Na2O12S4



SYNONYMS:
Disodium Bisdisulizole, Disodium Phenyldibenzimidazoletetrasulfonate, Disodium 2,2′-(1,4-phenylene)bis(6-sulfo-1H-1,3-benzimidazole-4-sulfonate), Bisdisulizole disodium (USAN), 180898-37-7, Neo heliopan AP (TN), SCHEMBL269341, IPQNYPRUKKNNRT-UHFFFAOYSA-N, D06568, Phenyldibenzimidazole tetrasulfonate, disodium salt, Bisdisulizole disodium (INN), Bisimidazylates, 6-Sulfo-2-[4-(6-sulfo-4-sulfonato-1H-benzimidazol-2-yl)phenyl]-1H-benzimidazole-4-sulfonate disodium salt (IUPAC), 2,2′-(1,4-phenylene)-bis(1H-benzimidazole-4,6-disulfonic acid disodium salt), DISODIUM PHENYL DIBENZIMIDAZOLE TETRASULFONATE (INCI) [1], DPDT, 2,2'-(1,4-phenylene)bis(1H-benzo[d]imidazole-4,6-disulfonic acid), 1H-Benzimidazole-5,7-disulfonic acid, 2,2'-(1,4-phenylene) Sodium Salt, 1H-Benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene) Sodium Salt, Bisdisulizole Sodium, Bisimidazylate Sodium Salt, Sodium Bisdisulizole, Disodium Phenyldibenzimidazoletetrasulfonate Sodium Salt, Neo Heliopan Sodium Salt, Neo Heliopan APC Sodium Salt, 2,2'-(1,4-phenylene)bis(1H-benzo[d]imidazole-4,6-disulfonic acid), Neo Heliopan AP, Bisdisulizole Disodium, 1H-Benzimidazole-5,7-disulfonic acid, 2,2'-(1,4-phenylene) Sodium Salt, 1H-Benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene) Sodium Salt, Bisdisulizole Sodium, Bisimidazylate Sodium Salt, Sodium Bisdisulizole, Disodium Phenyldibenzimidazoletetrasulfonate Sodium Salt, Neo Heliopan Sodium Salt, Neo Heliopan APC Sodium Salt



Neo Heliopan AP is an electrolyte and therefore will have an effect upon the viscosity of carbomer-thickened emulsions or gels.
The addition of a non-carbomer derived thickening agent such as xanthan gum and its derivatives will increase the viscosity of the formulation.
If Neo Heliopan AP is combined with Zinc Oxide we recommend to disperse Neo Heliopan AP directly into the aqueous phase and then dissolve it by adding the neutralizing agent until a pH of about 5 is reached.


Neo Heliopan AP is a condition at 20°C yellow to dark yellow powder
Neo Heliopan AP has practically odorless (comparable to standard)
Neo Heliopan AP is a highly effective and photostable UVA II absorber.


Neo Heliopan AP forms water soluble salts with the addition of a base.
Neo Heliopan AP is a water-soluble organic compound known for its exceptional efficacy and photostability as a UVA II absorber.
Neo Heliopan AP exhibits a strong UV absorbance (1%/1cm) of at least 770 at approximately 335nm.


Neo Heliopan AP finds its application in sunscreens, where it effectively absorbs UVA rays.
Neo Heliopan AP is derived from benzimidazole.
Neo Heliopan AP is a water-soluble organic compound which is added to sunscreen products to absorb UVA rays.


This organic compound, Neo Heliopan AP, has an excellent safety profile including extremely low skin penetration.
Neo Heliopan AP is a highly effective UVA ii absorber with a UV absorbance
Neo Heliopan AP is a water-soluble organic compound that is added to sunscreens to absorb UVA rays.


Neo Heliopan AP is a water-soluble broad-spectrum UV absorber with an absorption maximum λ max in the UV-A range at 335 nm.
Neo Heliopan AP was approved as a sunscreen in Europe in 2000.
Neo Heliopan AP is marketed in sunscreen preparations in concentrations of up to 10 % in the European Union, Australia and New Zealand, South Africa, South Korea, China, the ASEAN and Mercosur countries; it is not approved in the USA and Japan.


In combination with oil-soluble UV B filters, such as octocrilene or enzacamen , Neo Heliopan AP causes an increase in the sun protection factor of approximately 40%.
As a relatively large (MW>600) and polar tetrasulfonic acid derivative, Neo Heliopan AP penetrates only very slightly into the skin and, due to its water solubility, can be formulated not only in O/W emulsions but also in clear aqueous sunscreen preparations such as gels and sprays.


Neo Heliopan AP is ultraviolet absorbent, absorbing wavelength between 290-370nm.
Neo Heliopan AP is water-soluble UVA protective agent, with good light stability, usually used in sunscreen and daily care products.
Neo Heliopan AP is a general chemical, with good storage and transportation stability, it is non-flammable and non-explosive, non-toxic and harmless.



USES and APPLICATIONS of NEO HELIOPAN AP:
Neo Heliopan AP acts as an effective UVA II absorber.
Neo Heliopan AP is highly photostable, hygroscopic and compatible with ingredients and packaging.
In sun care formulations Neo Heliopan AP shows synergistic effects with oil-soluble UVB filters.


In combination with the UVA I absorber Neo Heliopan AP very broad spectrum UVA protection products can be formulated.
Neo Heliopan AP forms water soluble salts with the addition of a base.
Neo Heliopan AP possesses an excellent safety profile including extremely low skin penetration.


Neo Heliopan AP provides UV protection and it is suitable for water-based transparent sunscreen products such as gels or clear sprays.
Neo Heliopan AP is a retinoid that is used as a topical photoprotective agent.
Neo Heliopan AP is water-soluble and can be absorbed through the skin.


Neo Heliopan AP also has antioxidant activity, which may help to protect against ultraviolet light-induced skin damage.
Neo Heliopan AP protects against 320-350 nm with peak at 335 nm.
Neo Heliopan AP is water-soluble.


Neo Heliopan AP is approved for worldwide use at 10% except in the US.
Neo Heliopan AP is a water-soluble organic compound that is added to sunscreens to absorb UVA rays.
This long-named molecule is a chemical sunscreen agent that protects the skin from the UVA II rays (320-350 nm mainly) with a peak absorbance at 335 nm.


Unlike most other sunscreen filters, it is not oil, but water-soluble helping formulators to create less greasy sunscreens.
Neo Heliopan AP also has a good safety profile with very low skin penetration and is approved up to 10% in the EU and pretty much everywhere else except for the United States (due to old and bad FDA sunscreen regulations).



CLAIMS OF NEO HELIOPAN AP:
*Sunscreen Agents > UV Filters / Sunscreens protections
*UVA Absorber



THE BENEFITS OF NEO HELIOPAN AP:
• Neo Heliopan AP is a highly effective and photostable UVA II absorber with an UV absorbance ( E 1%) of min 770 at around 335 nm which forms water soluble salts with the addition of a base.
• Neo Heliopan AP is practically odorless, has an excellent stability and is compatible with other ingredients and packaging
• In sun care formulations Neo Heliopan AP shows synergistic effects with oil-soluble UVB filters
• In combination with the UVA I absorber Neo Heliopan AP very broad spectrum UVA protection products can be formulated
• Neo Heliopan AP has an excellent safety profile including extremely low skin penetration
• Neo Heliopan AP is suitable for water-based transparent sunscreen products such as gels or clear sprays
• Waterproof sunscreens can be formulated
• Neo Heliopan AP is fluorescent on exposure to UV light but this can be quenched by the application of Troxerutin.
• Approved up to 10% in: Europe, Australia, Mercosur, South Africa, China, Taiwan, South Korea and the ASEAN
states (further information under the legislation part page 08/09).
• Neo Heliopan AP is a safe and effective UVA absorber.



MANUFACTURING OF NEO HELIOPAN AP:
Purified 1,2-phenylenediamine is dissolved in concentrated sulfuric acid and chlorosulfonic acid is added dropwise.
The mixture is heated briefly to 120 °C while evolving hydrogen chloride , then cooled to 70 °C and terephthalic acid is added.

After further heating to 180 °C while evolving HCl, the mixture is cooled to 80 °C and poured onto ice, whereupon the tetrasulfonic acid precipitates in crystalline form.

For purification, Neo Heliopan AP is dissolved in sodium hydroxide solution and boiled with activated carbon .
When sulfuric acid is added, Neo Heliopan AP is obtained as a symmetrical di-4,6-sulfonate in 99% purity.

The reaction of o -phenylenediamine with terephthalic acid and chlorosulfonic acid at 110–120 °C and a reaction time of 10 to 15 hours yields Neo Heliopan AP in 98% purity after repeated recrystallization.
The Neo Heliopan AP thus obtained contains small amounts of tetrasulfonic acid and trisulfonic acid, which are asymmetrically sulfonated on one side in the 4,5-position, as byproducts, which do not represent problematic impurities.



CHARACTERISTICS OF NEO HELIOPAN AP:
Neo Heliopan AP is an odorless, yellow, finely crystalline, highly hygroscopic solid which dissolves in water up to 12% as the disodium salt of the underlying tetrasulfonic acid .

However , when bases such as triethanolamine (TEA) are added, the tetrasulfonate dissolves very well in water at room temperature.
Neo Heliopan AP, as a triethanolamine salt in water, has a UV absorption under standard conditions (1% solution, 1 cm layer thickness) E 1%/1cm of approximately 770 at a wavelength of approximately 335 nm in the UVA II range (320–340 nm).
The absorption spectrum of Neo Heliopan AP is relatively broad and extends from the shorter-wave UVB range (290–320 nm) to the UVA I range (340–400 nm).



PREPARATION OF NEUTRALIZED AQUEOUS SOLUTIONS OF NEO HELIOPAN AP:
Disperse Neo Heliopan AP in water with stirring.
The amount of water used in this step may not exceed 2/3 of the residual scheduled quantity.
Neutralize the dispersion up to the needed pH value* while stirring thoroughly, at the end of the neutralizing process add the base slowly, as solubilizing of residual Neo Heliopan AP may take some time.

The neutralized solution must be nearly clear.
Fill up to 100% with water and stir until homogeneous.

*In aqueous solutions with high concentration of Neo Heliopan AP, the pH value preventing recrystallization of Neo Heliopan AP vary with the used neutralization agent:
Biotive L- Arginine: 6.2 – 6.5
Triethanolamine: 7.0 – 8.0
Sodium Hydroxide: 7.0 – 8.0



IMPORTANT ADVICE OF NEO HELIOPAN AP FOR FORMULATIONS:
Neo Heliopan AP is a fine yellow powder.
The free acid is virtually insoluble in water.
By the addition of a base such as sodium hydroxide, potassium hydroxide or triethanolamine the water soluble salts will be formed.

Neo Heliopan AP can be added non-neutralized to the aqueous phase of the formulation, addition of a neutralization base with vigorous stirring will form the salt which then dissolves into the aqueous phase.

Neo Heliopan AP can be also added as aqueous pre-mix.
In finished formulations Neo Heliopan AP is stable in a wide pH range (5.0 –9.0) without incurring the risk of crystallization.

Care has to be taken when Neo Heliopan AP is used in the presence of quaternary ammonium salts since complexes may form.
Tocopherol is known to incur discoloration problems in a number of formulations; therefore we recommend the usage of tocopheryl acetate when formulating with Neo Heliopan AP.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN AP:
CAS No.: 180898-37-7
ELINCS: 429-750-0
UV-A absorber: water soluble
Molecular Weight: 674.59 g/mol
INCI name: Disodium Phenyl Dibenzimidazole Tetrasulfonate
Chemical names: 2,2’-(1,4-Phenylene) bis-[1H-benzimidazole-4, 6-disulfonic
acid], disodium salt
Empirical Formula: C20H12N4Na2O12S4
Assay (HPLC; Sum of 3 isomers) %: min. 96.0
Non volatile residue %: min. 97.0
Flash point °C: <100

Specific extinction E 1% ,
in water as sodium salt at λ max. 335 nm: min. 770
Solubility of Neo Heliopan® AP at 20°C in: Ethanol 96 Vol% <0.1%
Water (as free acid) 1%
Water (as Arginine salt) 15%
Water (as sodium salt) 12%
not soluble in oil
Shelf life and storage conditions: 36 months in the original,
unopened container, dry, at 5 to 40°C.
Physical State: Solid

Storage: Store at -20°C
Molecular Weight: 674.6 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 16
Rotatable Bond Count: 6
Exact Mass: 673.91299509 g/mol
Monoisotopic Mass: 673.91299509 g/mol
Topological Polar Surface Area: 279 Ų
Heavy Atom Count: 42
Formal Charge: 0
Complexity: 1280

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
Compound Name: Bisdisulizole (Neo Heliopan AP)
Synonyms: 2,2'-(1,4-phenylene)bis(1H-benzo[d]imidazole-4,6-disulfonic acid)
CAS#: 170864-82-1
Alternate CAS#: 180898-37-7 (Disodium Salt)

Molecular Formula: C20H14N4O12S4
Molecular Weight: 630.59 g/mol
CAS#: 180898-37-7
Appearance: Yellow to dark yellow
Assay: 99.64%
Storage: Cool and dry place
Shelf Life: 2 Years
CAS#: 180898-37-7
MDL No.: MFCD19705197
PSA: 314.02 Ų

LogP: 5.40
Appearance: Yellow fine powder
Sensitivity: Hygroscopic
Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Storage Condition: Store at RT
CAS#: 180898-37-7
Molar Mass: 674.57 g/mol
State of Aggregation: Firmly
Melting Point: > 280°C
Solubility: Soluble in water (12% at 20°C)



FIRST AID MEASURES of NEO HELIOPAN AP:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN AP:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN AP:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN AP:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN AP:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN AP:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan AV is highly effective UVB absorber with a specific extinction of min. 830 at around 308 nm in methanol and has additional absorption in the shorter UVA-II range (320 to 340 nm)
Neo Heliopan AV also acts as a very good solubilizer for crystalline UV absorbers.


CAS Number: 5466-77-3
EC Number: 226-775-7
UV-B absorber: oil soluble
Molecular Weight: 290.44 g/mol
INCI name: Ethylhexyl Methoxycinnamate
USAN: Octinoxate
INCI Name: ETHYLHEXYL METHOXYCINNAMATE
Chemical Composition: 2-Ethylhexyl p-methoxycinnamate
Chemical names: 2-Ethylhexyl p-Methoxycinnamae
Empirical Formula: C18H26O3



SYNONYMS:
Neo Heliopan Hydro, Eusolex 232, Parsol HS, Octinoxate, Parsol MCX, Parsol MOX, 2-Ethylhexyl p-methoxycinnamate, 2-Ethylhexyl-4-methoxycinnamate, 2-Ethylhexyl methoxycinnamate, 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethylhexyl ester, Escalol 557, Neo heliopan AV, Neo heliopan, type AV, Octyl methoxy cinnamate, 2-Ethylhexyl 3-(4-methoxyphenyl)-2-propenoate, NSC 26466, Sunscreen AV, Uvinul MC 80, UvinulT MC 80 N, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, Parsol MCX, 2-Ethylhexyl p-methoxycinnamate, Neo Heliopan AV, Sunscreen AV, 2-Ethylhexyl 4-methoxycinnamate, Ethylhexyl p-methoxycinnamate, Octyl 4-methoxycinnamate, Octyl p-methoxycinnamate, Parsol MCX-SA, Escalol 557, p-Methoxycinnamic acid 2-ethylhexyl ester, Uvinul 3088, Eusolex 2292, Uvinul MC 80, Octinoxate, Uvinul MC 80N, Octyl methoxycinnamate, 4-Methoxycinnamic acid 2-ethylhexyl ester, Parsol MOX, Tinosorb OMC, Escalol 557T, NSC 26466, Escalol 557NB, Uvinul MC 90, Jeescreen OMC, Sun Caps 664, Solarom OMC, Ethylhexyl methoxycinnamate, 2-Ethylhexyl methoxycinnamate, 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethylhexyl ester, Nomcort TAB-R, Nomcort TAB, Uvinal MC 80, 2-Ethylhexyl3-(4-methoxyphenyl)acrylate, Uninul MC 80, Parsol MVX, 83834-59-7, 226-775-7, 2-ETHYLHEXYL 4-METHOXYCINNAMATE, 2-ETHYLHEXYL METHOXYCINNAMATE, 2-ETHYLHEXYL P-METHOXYCINNAMATE, 2-ETHYLHEXYL TRANS-4-METHOXYCINNAMATE, 2-ETHYLHEXYL-P-METHOXYCINNAMATE, 2-PROPENOIC ACID, 3-(4-METHOXYPHENYL)-, 2-ETHYLHEXYL ESTER, 2-PROPENOIC ACID, 3-(4-METHOXYPHENYL)-, 2-ETHYLHEXYL ESTER, (2E)-, 2-PROPENOIC ACID, 3-(4-METHOXYPHENYL)-, 2-ETHYLHEXYL ESTER, (E)-, 4-METHOXYCINNAMIC ACID 2-ETHYLHEXYL ESTER, ESCALOL 557, ESCALOL 557NB, ESCALOL 557T, ETHYLHEXYL METHOXYCINNAMATE, ETHYLHEXYL P-METHOXYCINNAMATE, ETHYLHEXYL P-METHOXYCINNAMATE [VANDF], EUSOLEX 2292, EUSOLEX UV-PEARLS OMC, JEESCREEN OMC, NEO HELIOPAN AV, NSC-26466, OCINOXATE, OCTINOXATE [HSDB], OCTINOXATE [INN], OCTINOXATE [MART.], OCTINOXATE [ORANGE BOOK], OCTINOXATE [USAN], OCTINOXATE [USP MONOGRAPH], OCTINOXATE [USP-RS], OCTINOXATE [VANDF], OCTINOXATE [WHO-DD], OCTYL 4-METHOXYCINNAMATE, OCTYL METHOXYCINNAMATE, OCTYL METHOXYCINNAMATE [MI], OCTYL METHOXYCINNAMATE [VANDF], OCTYL P-METHOXYCINNAMATE, OCTYLMETHOXYCINNAMATE, PARSOL, PARSOL MCX, PARSOL MCX-SA, PARSOL MOX, P-METHOXYCINNAMIC ACID 2-ETHYLHEXYL ESTER, SHADE UVAGUARD COMPONENT OCTINOXATE, SOLAROM OMC, SUN CAPS 664, SUNSCREEN AV, TINOSORB OMC, UVINUL 3088, UVINUL MC 80, UVINUL MC 80N, UVINUL MC 90, UVINUL MC80



Neo Heliopan AV is a highly effective, oil-soluble and liquid UVB absorber for a wide variety of cosmetic applications.
Neo Heliopan AV offers additional absorption in the short-wave UVA spectrum and UV protection.
Neo Heliopan AV also acts as a very good solubilizer for crystalline UV absorbers.


Neo Heliopan AV is suitable for the formulation of water-resistant sunscreen products.
Neo Heliopan AV is world-wide approved.
Neo Heliopan AV is a condition at 20°C clear, colorless to light yellow liquid.


Neo Heliopan AV has practically odorless (comparable to standard).
Neo Heliopan AV is oil-soluble
Neo Heliopan AV is highly effective UVB absorber with a specific extinction of min. 830 at around 308 nm in methanol and has additional absorption in the shorter UVA-II range (320 to 340 nm)


Neo Heliopan AV is excellent solvent for crystalline and oil-soluble UV absorbers such as Neo Heliopan® 357, BMT, BB, MBC as well as Ethylhexyl Triazone, Diethylhexyl Butamido Triazone and Diethylamino Hydroxybenzoyl Hexyl Benzoate
Neo Heliopan AV is suitable Vegan according to Symrise policy.


Neo Heliopan AV is halal & Kosher status available on request.
Neo Heliopan AV is a highly effective, liquid UVB absorber that is oil-soluble.
Neo Heliopan AV is an excellent solubilizer for crystalline UV absorbers and is approved world-wide.


Neo Heliopan AV is an effective oil-soluble liquid UVB absorber for a wide variety of cosmetic applications.
Neo Heliopan AV provides additional absorption in the shortwave UVA spectrum and UV protection.
Neo Heliopan AV is a highly effective, liquid UVB absorber that is oil-soluble.


Neo Heliopan AV is an excellent solubilizer for crystalline UV absorbers and is approved world-wide.
Neo Heliopan AV, also known as Ethylhexyl Methoxycinnamate, is a common ingredient in many sunscreens and other skincare products.
Neo Heliopan AV is a clear, colorless liquid that is derived from natural sources, such as cinnamon leaves.


Neo Heliopan AV is also known for its trade names such as Eusolex 2292, and Uvinul MC80.
Neo Heliopan AV is a highly effective, liquid UVB absorber that is oil-soluble.
Neo Heliopan AV is an excellent solubilizer for crystalline UV absorbers and is approved world-wide.



USES and APPLICATIONS of NEO HELIOPAN AV:
Neo Heliopan AV's primary use is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage.
Neo Heliopan AV is also used to reduce the appearance of scars after surgery.
Neo Heliopan AV is used in sunscreens because of its ability to absorb UVB radiation from the sun, which can cause sunburn and skin damage.


Neo Heliopan AV is also used in other skincare products because of its ability to improve the texture and appearance of the skin.
Neo Heliopan AV is used as an effective oil soluble and liquid UVB absorber with a specific extinction (E 1% / 1cm) of min. 830 at 308nm in Methanol and has additional absorption in the short-wave UVA spectrum.


Neo Heliopan AV is used in a wide variety of cosmetic applications.
Neo Heliopan AV offers additional absorption in the short-wave UVA spectrum and UV protection.
Neo Heliopan AV also acts as a very good solubilizer for crystalline UV absorbers.


Neo Heliopan AV is suitable for the formulation of water-resistant sunscreen products.
Neo Heliopan AV is a UVB absorbing agent used in products such as sunscreens and cosmetic creams, lotions, lipsticks, hair care products, sun oils and some insect repellents.


Further research may identify additional product or industrial usages of Neo Heliopan AV.
Neo Heliopan AV is used as an effective oil soluble and liquid UVB absorber with a specific extinction (E 1% / 1cm) of min. 830 at 308nm in Methanol and has additional absorption in the short-wave UVA spectrum.


Neo Heliopan AV is used in a wide variety of cosmetic applications.
Neo Heliopan AV offers additional absorption in the short-wave UVA spectrum and UV protection.
Neo Heliopan AV also acts as a very good solubilizer for crystalline UV absorbers.


Neo Heliopan AV is suitable for the formulation of water-resistant sunscreen products.
Neo Heliopan AV is a used UVB absorber that is oil soluble and virtually odorless.
Neo Heliopan AV is suitable for a wide variety of cosmetic applications.


Neo Heliopan AV remains a liquid at temperatures as low as -10°C.
Neo Heliopan AV may increase FPS when used in combination with other UV filters.
Ideal for formulating water-resistant sun protection products


Neo Heliopan AV is an excellent solubilizer for crystalline UV absorbers.
Neo Heliopan AV is approved worldwide.
Maximum concentration varies according to local legislation


Neo Heliopan AV is a safe and effective UVB absorber.
Neo Heliopan AV is a high-quality sunscreen that provides advanced sun protection against UVA and UVB rays.
Neo Heliopan AV is specially formulated to protect the skin from sun damage and premature aging.
Neo Heliopan AV is lightweight, non-greasy, and suitable for daily use.



CLAIMS OF NEO HELIOPAN AV:
*Sunscreen Agents > UV Filters / Sunscreens protections
*UVB Absorber



THE BENEFITS OF NEO HELIOPAN AV:
• Neo Heliopan AV is a highly effective UVB absorber with a specific extinction (E 1% ) of min. 830 at around
308 nm in Methanol and has additional absorption in the shorter UV-A II range (320 to 340 nm).
• Neo Heliopan AV is oil soluble and virtually odorless and suitable for a wide variety of cosmetic applications.
• Neo Heliopan AV is an excellent absorber for UV broad spectrum protection and also for water resistant products.
• The absorber is excellent compatible with cosmetic ingredients and easily to incorporate into emulsions; cold
processing is possible.
• Neo Heliopan AV is an excellent solvent for crystalline and oil-soluble UV absorbers.
• Neo Heliopan AV has a moderate photostability, but when used at 2% together with 5% Neo Heliopan® 357 and other UVB filters both filters are relatively photostable.
• Neo Heliopan AV is approved world-wide.
Concentration maximum varies according to local legislation.
• Neo Heliopan AV is a safe and effective UVB absorber. Safety and efficacy studies are available on request.



FUNCTIONS OF NEO HELIOPAN AV:
Sunscreen Physical sunscreens work by deflecting or scattering UV rays.
Chemical sunscreens work by absorbing and dissipating the UV rays as heat.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN AV:
CAS No.: 5466-77-3
EINECS: 226-775-7
UV-B absorber: oil soluble
Molecular Weight: 290.44 g/mol
INCI name: Ethylhexyl Methoxycinnamate
USAN: Octinoxate
Chemical names: 2-Ethylhexyl p-Methoxycinnamae
Empirical Formula: C18H26O3
Assay (GLC) %: min. 98
Single impurity >0.5%: not detectable
Sum of impurities >2.0%: not detectable
Butylhydroxytoluene (BHT) %: 0.05 – 0.10
Relative density (D25/25): 1.005 – 1.013

Relative density (D20/4): 1.007 – 1.014
Refractive Index (n20/D): 1.543 – 1.547
Specific extinction E 1% ,
in methanol λ max. 307/308 nm: min. 830
Solubility at 20°C in: Readily soluble in most cosmetic oils except glycols.
Shelf life and storage conditions: 36 months in the original,
unopened container, dry, at 5 to 40°C.
InChI: InChI=1S/C18H26O3/c1-4-6-7-15(5-2)14-21-18(19)13-10-16-8-11-17(20-3)12-9-16/h8-13,15H,4-7,14H2,1-3H3
InChIKey: InChIKey=YBGZDTIWKVFICR-UHFFFAOYSA-N
SMILES: C(=CC(OCC(CCCC)CC)=O)C1=CC=C(OC)C=C1
Canonical SMILES: O=C(OCC(CC)CCCC)C=CC1=CC=C(OC)C=C1
CAS Name: 2-Ethylhexyl 4-methoxycinnamate
Molecular Formula: C18H26O3
Molecular Mass: 290.40



FIRST AID MEASURES of NEO HELIOPAN AV:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN AV:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN AV:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN AV:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN AV:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN AV:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan BB is a pale-yellow colored solid soluble in most organic solvents.
Neo Heliopan BB also occurs naturally in many different kinds of plants.


CAS Number: 131-57-7
EC Number: 205-031-5
UV-A/UV-B absorber: oil soluble
Molecular Weight: 228.26 g/mol
INCI name: Benzophenone-3
USAN: Oxybenzone
Chemical Composition: 2-Hydroxy-4-methoxybenzophenone
Chemical names: 2-Hydroxy-4-methoxybenzophenone
Empirical Formula: C14H12O3



SYNONYMS:
(2-Hydroxy-4-methoxyphenyl)(phenyl)methanone, Oxybenzone, Benzophenone-3, 2-Hydroxy-4-methoxybenzophenone, Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-, Benzophenone, 2-hydroxy-4-methoxy-, Advastab 45, Anuvex, Benzophenone-3, Chimassorb 90, Cyasorb uv 9, Cyasorb uv 9 light absorber, Mob, Oxybenzon, Spectra-sorb UV 9, Sunscreen UV-15, Uvinul M 40, Uvinul 9, Uvistat 24, UF 3, UV 9, 2-Hydroxy-4-methoxybenzophenone, 4-Methoxy-2-hydroxybenzophenone, MOD, Syntase 62, USAF cy-9, (2-Hydroxy-4-methoxyphenyl)phenylmethanone, NCI-C60957, NSC-7778, 2-Benzoyl-5-methoxyphenol, Escalol 567, Eusolex 4360, HMBP, Neo heliopan BB, Ongrostab HMB



Neo Heliopan BB is a broad spectrum solar filter active with maximal UV absorbance (UV/A) in the range of 320-400 nm.
Neo Heliopan BB is an oil soluble filter
Neo Heliopan BB, also known as benzophenone-3 is an organic compound that belongs to a class of aromatic ketones.


Neo Heliopan BB is a pale-yellow colored solid soluble in most organic solvents.
Neo Heliopan BB also occurs naturally in many different kinds of plants.
Neo Heliopan BB is widely used in the manufacturing of things like plastics, toys, furniture finishes, etc.


Benzophenone-3 is also known as Neo Heliopan BB.
Neo Heliopan BB is naturally occurring UV protectant.
But Neo Heliopan BB is commercially produced.


Neo Heliopan BB is used ultraviolet light absorber and stabilizer, esp in plastics and paints.
Neo Heliopan BB is used in sun care products.
Neo Heliopan BB can be used up to 0.5% as a light stabilizer for cosmetic formulations.



USES and APPLICATIONS of NEO HELIOPAN BB:
Neo Heliopan BB is a white or pale yellow powder.
Neo Heliopan BB is used mostly in the formulation of nail polishes and enamels, but can also be used in bath products, makeup products, hair products, sunscreens and skin care products to protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays.


When used as a sunscreen ingredient, Neo Heliopan BB protects the skin from UV rays.
Neo Heliopan BB is an active ingredient with properties to absorb harmful UV radiation.
Exposure to harmful UV radiation causes series of changes in the formation of skin protein and adversely affects to the skin structure, which may lead to the formation of fine line and wrinkles, in turn, premature aging of the skin.


Moreover, Neo Heliopan BB causes sunburn which may be painful at times.
Neo Heliopan BB absorbs these harmful rays and protects the skin from damage.
Neo Heliopan BB is known to reduce wrinkles, fine lines, and dark spots formed on the skin due to photoaging.


Neo Heliopan BB works in dual ways, first, it helps the skin protect against harmful or damaging sun rays and secondly, in cosmetic products to protect the product from deterioration due to exposure to the sun.
Neo Heliopan BB stabilizes the complex formula of the product and also colored products.


Neo Heliopan BB is mainly used in formulations of sunscreens, color cosmetics, and fragrances for other cosmetic products.
Neo Heliopan BB has a unique quality of absorbing and dissipating harmful UVA and UVB rays when applied to the skin.
This allows Neo Heliopan BB to protect the surface from UVB rays and the layers underneath from UVA.


Neo Heliopan BB stabilizes the product by its protective effect from sunlight allowing it the product to have a longer shelf life.
Neo Heliopan BB is also used in products such as sunscreen, lotions, nail polish, hair care, photo paper and lipstick.
Neo Heliopan BB is used in plastics as an ultraviolet light absorber and stabilizer.


Neo Heliopan BB is used, along with other benzophenones, in sunscreens, hair sprays, and cosmetics because they help prevent potential damage from sunlight exposure.
Neo Heliopan BB is also found, as a stabilizer in concentrations up to 1%, in nail polishes.


Neo Heliopan BB can also be used as a photostabilizer for synthetic resins.
Neo Heliopan BB can leach from food packaging, and is widely used as photo-initiators to activate a chemical that dries ink faster.
Despite its photoprotective qualities, much controversy surrounds Neo Heliopan BB because of possible negative hormonal and photoallergenic effects, leading many countries to regulate use in sunscreen products.


A chemical sunscreen agent that absorbs UVB and short UVA rays (280-350nm) with Neo Heliopan BB's peak protection at 288 nm.
Unlike many other chemical sunscreens, Neo Heliopan BB is highly stable but its UV absorbing abilities are weak so it always has to be combined with other sunscreen agents for proper protection.


More often than not, Neo Heliopan BB's used as a photostabilizer rather than a proper sunscreen agent as it can protect formulas nicely from UV damage.
Neo Heliopan BB is a widely used chemical compound in cosmetics and sunscreens.


Neo Heliopan BB's chemical formula is C14H12O3.
This organic UV filter, Neo Heliopan BB, serves as a sunblock agent, absorbing and dissipating harmful ultraviolet (UV) rays, particularly UVB and some UVA radiation.


Neo Heliopan BB helps protect the skin from sunburn and UV-induced damage, making it a common ingredient in sunscreens, lotions, and lip balms.
Neo Heliopan BB acts as an effective broad-spectrum absorber.
Neo Heliopan BB offers maximum protection in the short-wave UVB and UVA spectra.


Neo Heliopan BB is a condition at 20°C light yellow to yellow powder
Neo Heliopan BB has practically odorless (comparable to standard)
Neo Heliopan BB is oil-soluble.


Neo Heliopan BB is effective broad spectrum absorber with max. protection in the short-wave UVB and UVA spectra (UVB at approx. 285 nm, UVA at approx. 325 nm).
Neo Heliopan BB can be used up to 0.5% as a light stabilizer for cosmetic formulations.


Neo Heliopan BB is suitable Vegan according to Symrise policy.
Neo Heliopan BB is halal & Kosher status available on request.
Neo Heliopan BB is an effective oil-soluble broad spectrum absorber with protection in the short-wave UVB and UVA spectra.


Neo Heliopan BB is an effective oil-soluble broad spectrum absorber with protection in the short-wave UVB and UVA spectra.
Neo Heliopan BB is an organic compound belonging to the class of aromatic ketones known as benzophenones.
Neo Heliopan BB takes the form of pale-yellow crystals that are readily soluble in most organic solvents.


Neo Heliopan BB is widely used in sunscreen formulations, plastics, toys, furniture finishes, and other products to limit UV degradation.
In nature, Neo Heliopan BB can be found in various flowering plants (angiosperms).
Neo Heliopan BB was first synthesised in Germany by chemists König and Kostanecki in 1906.


-Sunscreen uses of Neo Heliopan BB:
Neo Heliopan BB provides a broad-spectrum ultraviolet coverage which includes UVB and short-wave UVA rays.
As a photoprotective agent, Neo Heliopan BB has an absorption profile spanning from 270 to 350 nm with absorption peaks at 288 and 350 nm.



WHAT IS NEO HELIOPAN BB USED FOR?
Neo Heliopan BB is a key ingredient in sunscreens and cosmetics.
Neo Heliopan BB's primary role is to protect the skin from the harmful effects of UV radiation.
Neo Heliopan BB absorbs UVB and some UVA rays, shielding the skin from sunburn and UV-induced damage.

Neo Heliopan BB is a popular choice in sunscreens due to its broad-spectrum UV protection capabilities.
Additionally, Neo Heliopan BB is used in various cosmetics like lip balms and moisturizers to provide UV protection and prevent sun damage, making it an essential component in the fight against skin aging and skin cancer caused by excessive sun exposure.



ORIGIN OF NEO HELIOPAN BB:
Neo Heliopan BB is synthesized through esterification, where 3-benzoylbenzoic acid reacts with phenol, forming benzophenone-3 benzyl ester.
Subsequent hydrolysis breaks the ester bond, yielding the benzophenone-3 molecule.
Purification processes remove impurities, resulting in a white or pale yellow crystalline powder,Neo Heliopan BB, used in the cosmetic industry.



WHAT DOES NEO HELIOPAN BB DO IN A FORMULATION?
*Uv absorber
*Uv filter



SAFETY PROFILE OF NEO HELIOPAN BB:
Safety profile
Neo Heliopan BB has raised concerns about potential toxicity and environmental impact.
Consequently, some consumers and researchers advocate for alternative UV filters in sunscreen formulations.



ALTERNATIVES OF NEO HELIOPAN BB:
*TITANIUM DIOXIDE,
*ZINC OXIDE



CLAIMS OF NEO HELIOPAN BB:
*Sunscreen Agents > UV Filters / Sunscreens protections
*UVA/UVB Absorber



THE BENEFITS OF NEO HELIOPAN BB:
• Neo Heliopan BB is an effective broad spectrum absorber with max. protection in the short-wave UVB and UVA spectra (UVB at approx. 285 nm, UVA at approx. 325 nm).
• Neo Heliopan BB is an oil soluble, fine-crystalline powder and practically odorless.
Adequate solubility in the formulation must be ensured in order to avoid recrystallization of the Neo Heliopan BB.
The UV filters Neo Heliopan AV, E1000, 303, OS, HMS and certain emollients are excellent solvents.
• Neo Heliopan BB is an excellent co-absorber in combination with specific UVB absorbers (Neo Heliopan AV, E1000, OS, HMS, MBC or Hydro).
• In the USA often used in combination with Neo Heliopan AV, HMS and OS to achieve high SPFs.
• Neo Heliopan BB can be used up to 0.5% as a light stabilizer for cosmetic formulations.
• Approved world-wide.
Concentration maximum varies according to local legislation.
• Please note that formulations containing more than 0.5% Benzophenone-3 in the EU and in ASEAN states have to have the inscription “contains Oxybenzone” on the label.
• Neo Heliopan BB is a safe and effective UVA/UVB absorber.
st.



STRUCTURE AND ELECTRONIC STRUCTURE OF NEO HELIOPAN BB:
Being a conjugated molecule, Neo Heliopan BB absorbs light at lower energies than many aromatic molecules.
As in related compounds, the hydroxyl group is hydrogen bonded to the ketone.
This interaction contributes to Neo Heliopan BB's light-absorption properties.

At low temperatures, however, Neo Heliopan BB is possible to observe both the phosphorescence and the triplet-triplet absorption spectrum.
At 175 K the triplet lifetime is 24 ns.
The short lifetime has been attributed to a fast intramolecular hydrogen transfer between the oxygen of the C=O and the OH.



PRODUCTION OF NEO HELIOPAN BB:
Neo Heliopan BB is produced by the Friedel-Crafts reaction of benzoyl chloride with 3-methoxyphenol.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN BB:
CAS No.: 131-57-7
EINECS: 205-031-5
UV-A/UV-B absorber: oil soluble
Molecular Weight: 228.26 g/mol
INCI name: Benzophenone-3
USAN: Oxybenzone
Chemical names: 2-Hydroxy-4-methoxybenzophenone
Empirical Formula: C14H12O3
Assay (HPLC) %: 97.0 – 103.0
Solidification point °C: min 62.0
Melting point °C: min. 62.5

Loss on drying %: max. 2.0
Specific Extinction E 1% in Methanol (λ max. 321 - 327 nm): min. 400
Shelf Life and Storage Conditions: 36 months in the original,
unopened container, dry, at 5 to 40°C
Chemical Formula: C₁₄H₁₂O₃
Molar Mass: 228.247 g·mol⁻¹
Appearance: Pale yellow crystals
Density: 1.20 g/cm³
Melting Point: 62 to 65 °C (144 to 149 °F; 335 to 338 K)
Boiling Point: 224 to 227 °C (435 to 441 °F; 497 to 500 K)
Acidity (pKa): 7.6 (in H₂O)
Solubility: Insoluble in water



FIRST AID MEASURES of NEO HELIOPAN BB:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN BB:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN BB:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN BB:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.


HANDLING and STORAGE of NEO HELIOPAN BB:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN BB:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan BMT is suitable Vegan.
Neo Heliopan BMT has slight aromatic (comparable to standard)


CAS Number: 187393-00-6
EC Number: 425-950-7
UV-A/UV-B absorber: oil soluble
Molecular Weight: 627.8 g/mol
INCI name: Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Chemical names: 2,2‘-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]
bis{5-[(2-ethylhexyl)oxy]phenol}
INCI: Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Empirical Formula: C38H49N3O5



Neo Heliopan BMT is a condition at 20°C light yellow to yellow powder
Neo Heliopan BMT has slight aromatic (comparable to standard)
Neo Heliopan BMT is oil-soluble.


Neo Heliopan BMT is very effective and photostable broad spectrum absorber for a wide range of applications.
Maximum absorbance of Neo Heliopan BMT in isopropanol are at 310 nm, with a minimum specific extinction of 720 and at 340 nm, with a minimum specific extinction of 790 respectively


Neo Heliopan BMT is synergistic effect with UVB and UVA filters (SPF booster) and especially recommended for formulating sunscreens which shall meet the requirements of UVA/UVB balance due to its broad spectrum absorption.
Neo Heliopan BMT is suitable Vegan.


Neo Heliopan BMT is halal & Kosher status available on request.
Neo Heliopan BMT is a very effective broad spectrum UVA/UVB absorber for a wide range of applications.
Neo Heliopan BMT is oil soluble and especially recommended for formulating sunscreens which meet the requirements of UVA/UVB Balance.


Neo Heliopan BMT is a very effective and photostable broad spectrum absorber for a wide range of applications.
Maximum absorbance of Neo Heliopan BMT in isopropanol are at 310 nm, with a minimum specific extinction of 720 and at 340 nm, with a minimum specific extinction of 790 respectively.



USES and APPLICATIONS of NEO HELIOPAN BMT:
Neo Heliopan BMT has a synergistic effect with UVB and UVA filters (SPF booster) and is especially recommended for formulating sunscreens which shall meet the requirements of UVA/UVB Balance due to its broad-spectrum absorption.


Neo Heliopan BMT acts as a UVA and UVB Broad Spectrum absorber.
Neo Heliopan BMT offers characteristics such as ease of formulation and ability to photostabilize other UV filters.
Neo Heliopan BMT shows very good compatibility with cosmetic ingredients and other UV filters.


Neo Heliopan BMT is used in anti-aging formulas and sun protection products.
Neo Heliopan BMT is a very effective broad spectrum UVA/UVB absorber for a wide range of applications.
Neo Heliopan BMT is oil soluble and especially recommended for formulating sunscreens which meet the requirements of UVA/UVB Balance.



THE BENEFITS OF NEO HELIOPAN BMT:
• Neo Heliopan BMT is a very effective and photostable broad spectrum absorber for a wide range of applications.
• Maximum absorbance of Neo Heliopan BMT in isopropanol are at 310 nm, with a minimum specific extinction of 720 and at 340 nm, with a minimum specific extinction of 790 respectively.
• Neo Heliopan BMT is an oil soluble, crystalline powder with a slight aromatic odor.
Adequate solubility in the formulation must be ensured in order to avoid recrystallization of the Neo Heliopan BMT.
The UV filters Neo Heliopan E1000, 303, OS, HMS and certain emollients e.g. Corapan TQ (Diethylhexyl 2,6-Naphthalate) are excellent solvents.
• Neo Heliopan BMT has a synergistic effect with UV-B and UV-A filters (SPF booster) and is especially recommended for formulating sunscreens which shall meet the requirements of UVA/UVB Balance due to its broad spectrum
absorption.
• Approved to be used up to 10% in Europe, Switzerland, Australia, Mexico, Mercosur, ASEAN states, China, India,
Taiwan and South Korea.
Approved in Japan up to 3% in rinse-off and leave-on products.
• Neo Heliopan BMT is a safe and effective UVA/UVB broad spectrum absorber.



CLAIMS OF NEO HELIOPAN BMT:
*Sunscreen Agents > UV Filters / Sunscreens protections
*UVA/UVB Absorber



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN BMT:
CAS No.: 187393-00-6
ELINCS: 425-950-7
UV-A/UV-B absorber: oil soluble
Molecular Weight: 627.8 g/mol
INCI name: Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Chemical names: 2,2‘-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]
bis{5-[(2-ethylhexyl)oxy]phenol}
Empirical Formula: C38H49N3O5
Assay (HPLC) %: 98.0 – 100.0
Sum of impurities %: max. 2.0
Loss on drying (USP)%: max. 0.5
Specific extinction E 1% ,
in isopropanol λ max. 337 - 343 nm: min. 790
λ max. 307 - 313 nm: min. 720
Shelf life and storage conditions: 24 months in the original, unopened container, dry, at 5 to 40°C.



FIRST AID MEASURES of NEO HELIOPAN BMT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN BMT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN BMT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN BMT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN BMT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN BMT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan E1000 is a fairly new sun filter, apart from that, it is used in many cosmetic products.
Neo Heliopan E1000 is a highly effective UVB absorber with UV protection.


CAS Number: 71617-10-2
EC Number: 275-702-5
MDL number: MFCD00583856
UV-B absorber: oil soluble
Molecular Weight: 248.35 g/mol
INCI name: Isoamyl p-Methoxycinnamate
Chemical names: Isoamyl p-Methoxycinnamate
Isoamyl 2-(4-Methoxyphenyl)-2-Propenoate
Empirical Formula: C15H20O3



SYNONYMS:
4-Methoxycinnamic acid, isoamyl ester, AI3-05552, Amiloxate Isopentyl p-methoxycinnamate, Neo Heliopan E1000, Neo Heliopan E1000, Amyloxate, Isopentyl p-methoxycinnamate, Amiloxate, 71617-10-2, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl 3-(4-methoxyphenyl)acrylate, ISOPENTYL-4-METHOXYCINNAMATE, Isopentyl p-methoxycinnamate, ISOAMYL METHOXYCINNAMATE, 155339-66-5, NSC-408332, 3-methylbutyl (E)-3-(4-methoxyphenyl)prop-2-enoate, (E)-isopentyl 3-(4-methoxyphenyl)acrylate, isoamyl-p-methoxycinnamate, E-1000, 376KTP06K8, 4-Methoxycinnamic acid, isoamyl ester, NCGC00159435-02, 3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester, 3-methylbutyl 3-(4-methoxyphenyl)prop-2-enoate, Amiloxate [USAN], Neo Heliopan E1000, DTXSID1046055, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 3-methylbutyl ester, Amiloxate [USAN:USP], UNII-376KTP06K8, EINECS 275-702-5, MFCD00583856, Neo Heliopan (TN), BRN 3132627, Amiloxate (USP/INN), AMILOXATE [INN], AMILOXATE [MI], AI3-05552, AMILOXATE [MART.], E 1000, EC 275-702-5, AMILOXATE [USP-RS], AMILOXATE [WHO-DD], 3-Methylbutyl 3-(4-methoxyphenyl)-2-propenoate, SCHEMBL15764, 3-10-00-00850 (Beilstein Handbook Reference), AMILOXATE [USP IMPURITY], CHEMBL1476782, DTXCID9026055, 3-(4-Methoxyphenyl)-2-propenoic acid 3-methylbutyl ester, AMILOXATE [USP MONOGRAPH], CHEBI:135982, UBNYRXMKIIGMKK-RMKNXTFCSA-N, DTXSID301349309, 4-Methoxycinnamic acid-isoamyl ester, Tox21_111666, NSC408332, s3218, AKOS015913998, AKOS025310783, 1ST3423, CS-W012670, DB11207, HY-W011954, NSC 408332, isopentyl-4-methoxycinnamate, AldrichCPR, NCGC00159435-03, BS-49548, DA-54393, CAS-71617-10-2, D02904, Isoamyl 4-methoxycinnamate, analytical standard, SBI-0654197.0001, EN300-7363198, A837260, EN300-18004835, SR-01000201509, SR-01000201509-1, 3-(4-Methoxyphenyl)-2-propenoic acid, isoamyl ester, 3-Methylbutyl (2E)-3-(4-methoxyphenyl)-2-propenoate, 3-methylbutyl (2E)-3-(4-methoxyphenyl)prop-2-enoate, BRD-K37851352-001-01-0, Q17012246, Z212714982, Amiloxate, United States Pharmacopeia (USP) Reference Standard, 2-Benzoic acid, 2-propenoic acid, 3-(4-methoxyphenyl)-3-methylbutyl ester



Neo Heliopan E1000, a substance used as a chemical sun filter, can also be called "Isopentyl 4-methoxycinnamate" and Amiloxate.
Neo Heliopan E1000 is a clear, colorless, oily substance with the chemical formula (C₁₅H₂₀O₃).
Neo Heliopan E1000 is a natural substance obtained from cinnamon leaves.


Neo Heliopan E1000 provides protection against UVA and UVB.
Neo Heliopan E1000 is a fairly new sun filter, apart from that, it is used in many cosmetic products.
Neo Heliopan E1000 is a highly effective UVB absorber with UV protection.


Neo Heliopan E1000 is an excellent solubilizer for crystalline UV absorbers.
Neo Heliopan E1000 offers additional absorption in the short-wave UVA spectrum.
Neo Heliopan E1000 is suitable for the formulation of water resistant sunscreen products.


Neo Heliopan E1000 is an organic compound that absorbs ultraviolet (UV) light.
Neo Heliopan E1000 is a chemical ultraviolet filter.
Neo Heliopan E1000 is a fat-soluble transparent liquid from colorless to yellowish.


Neo Heliopan E1000 refers to semi-synthetic compounds. Isoamyl p-methoxycinnamate is identical to natural.
Neo Heliopan E1000 adsorbs type B ultraviolet radiation.
Neo Heliopan E1000 is an ingredient in some sunscreens.


Neo Heliopan E1000 is an absorber of ultraviolet B radiation.
Neo Heliopan E1000 is an ester of isoamyl alcohol and p-methoxycinnamic acid.
Neo Heliopan E1000 is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m.


Neo Heliopan E1000 is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate.
Neo Heliopan E1000 is a cinnamic acid derivative with an anti-inflammatory activity.



USES and APPLICATIONS of NEO HELIOPAN E1000:
In Europe, Neo Heliopan E1000 is an approved UV filter, which means the ingredient can be added to sunscreen products that are designed to protect the skin from the sun.
In Europe, sunscreen products are considered cosmetic products. In the United States, sunscreen products are Over-the-Counter (OTC) drugs and only certain ingredients have been approved by the Food and Drug Administration (FDA) for use in these products.


In assessing sunscreen active ingredients, the FDA reviews both safety and efficacy.
The safety and efficacy of Neo Heliopan E1000 has not yet been reviewed for sunscreen use by the FDA and it cannot be used in sunscreen drug products.
For cosmetics in the United States, Neo Heliopan E1000 can be used as a UV light absorber.


In this case, Neo Heliopan E1000 serves to protect the product from deterioration by absorbing, reflecting, or scattering UV light.
Neo Heliopan E1000 is a condition at 20°C clear, colorless to pale yellow liquid
Neo Heliopan E1000 has slight odor, no effect on the finished product (comparable to standard)


Neo Heliopan E1000 is oil-soluble.
Neo Heliopan E1000 is highly effective UVB absorber with a specific extinction of min. 980 at around 308 nm in methanol and has additional absorption in the shorter UVA-II range (320 to 340 nm).


Neo Heliopan E1000 is excellent solvent for crystalline and oil-soluble UV absorbers such as Neo Heliopan 357, BMT, BB, MBC as well as Ethylhexyl Triazone, Diethylhexyl Butamido Triazone and Diethylamino Hydroxybenzoyl Hexyl Benzoate.
Neo Heliopan E1000 is suitable Vegan according to Symrise policy.


Neo Heliopan E1000 is halal & Kosher status available on request.
Neo Heliopan E1000 is a highly effective oil-soluble, fluid UVB absorber offering additional absorption in the short-wave UVA spectrum.
Neo Heliopan E1000 is an excellent solubilizer for crystalline UV absorbers.


Neo Heliopan E1000 is an oil-soluble, chemical sunscreen agent that protects in the UVB (290-320 nm) range with a peak absorbance at 310 nm and with some additional protection in the UVA II (320-340nm) range.
Neo Heliopan E1000 is a newer generation UV filter that is approved up to 10% in the EU, but not (yet) available in the US due to impossible FDA regulations.


Neo Heliopan E1000 is a highly effective oil-soluble, fluid UVB absorber offering additional absorption in the short-wave UVA spectrum.
Neo Heliopan E1000 is an excellent solubilizer for crystalline UV absorbers.
Neo Heliopan E1000 is a fairly new sun filter, apart from that, it is used in many cosmetic products.


Neo Heliopan E1000 is used in cream, pre- and after-sun lotion, body milk, foundation, hair spray, face and body spray, fluid, serum, oil, sunscreen gel, CC cream, BB cream.
Neo Heliopan E1000 has slight odor, no effect on the finished product (comparable to standard)



APPLICATIONS OF NEO HELIOPAN E1000 IN COSMETICS:
Neo Heliopan E1000 has the ability to absorb ultraviolet light in the UVB wavelength range, as well as in the range of 320-340 nm, which corresponds to UVA rays.
When applied to the skin, Neo Heliopan E1000 protects against sunburn, skin photoaging, and the development of melanoma and other skin cancers caused by overexposure to ultraviolet radiation.

Neo Heliopan E1000 also has an anti-inflammatory, calming effect and reduces swelling even in small doses.
Neo Heliopan E1000 is used to protect children's, sensitive and atopic skin in combination with physical filters.
Neo Heliopan E1000 is a safe component; very few cases of allergic reactions have been described (only in case of individual intolerance).

Neo Heliopan E1000 has synergy with fat-soluble chemical filters.
Neo Heliopan E1000 is absolutely safe for use, as confirmed by toxicological and dermatological tests.
Neo Heliopan E1000 can be used to solubilize fat-soluble crystalline UV filters.
Neo Heliopan E1000 shows synergy with another filter: phenylbenzimidazole sulfonic acid.



FUNCTIONS OF NEO HELIOPAN E1000 IN COSMETICS PRODUCTS:
*LIGHT STABILIZER
Protecting the cosmetic product from deterioration effects of light

*UV ABSORBER
Neo Heliopan E1000 protects the cosmetic product from damage caused by UV light

*UV FILTER
Neo Heliopan E1000 protects skin or hair from harmful UV radiation



ORIGIN OF NEO HELIOPAN E1000:
Neo Heliopan E1000 is synthetic



OCCURRENCE OF NEO HELIOPAN E1000 IN COSMETICS:
As a UV filter in sunscreens and other cosmetics with UV protection (care products, decorative cosmetics); as a UV absorber for the protection of eg fragrances, colourants and active ingredients in the product and also for the protection of plastic packaging



CLAIMS OF NEO HELIOPAN E1000:
*Sunscreen Agents > UV Filters / Sunscreens
*protections
*absorption
*UVB Absorber



THE BENEFITS OF NEO HELIOPAN E1000:
• Neo Heliopan E1000 is a highly effective UVB absorber with a specific extinction (E 1% ) of min. 980 at around 308 nm in Methanol and has additional absorption in the shorter UV-A II range (320 to 340 nm).
• Neo Heliopan E1000 is oil soluble and virtually odorless and suitable for a wide variety of cosmetic applications.
• Neo Heliopan E1000 is an excellent absorber for UV broad spectrum protection and also for water resistant products.
• The absorber, Neo Heliopan E1000, is excellent compatible with cosmetic ingredients and easily to incorporate into emulsions; cold processing is possible.
• Neo Heliopan E1000 is an excellent solvent for crystalline and oil-soluble UV absorbers.
• Neo Heliopan E1000 is has a moderate photostability, but when used at 2% together with 5% Neo Heliopan® 357 and other UVB filters both filters are relatively photostable.
• Approved up to 10% in: Europe, Australia, Mercosur, ASEAN states, China, Taiwan, South Korea and South Africa (further information under the legislation part page 08/09).
• Neo Heliopan E1000 is a safe and effective UVB absorber.



PROPERTIES OF NEO HELIOPAN E1000:
Neo Heliopan E1000 adsorbs UVB radiation
Neo Heliopan E1000 is suitable for a wide range of cosmetic products
Neo Heliopan E1000 is an excellent solubilizer for solid UV filters

Neo Heliopan E1000 is an SPF booster
Neo Heliopan E1000 is ideal for preparing waterproof sunscreens
Neo Heliopan E1000 is not photostable



BACKGROUND INFORMATION OF NEO HELIOPAN E1000 ON USE IN COSMETICS:
Background information on use in cosmetics
Neo Heliopan E1000 is a soluble organic UV-B filter.
Neo Heliopan E1000 absorbs UV-B radiation from approximately 280 to 320 nm.

The maximum concentration of Neo Heliopan E1000 is 10 %.
UV filters minimise the undesired effects of UV radiation on the skin and are, therefore, an important component of sunscreens.
By protecting the skin against the dangerous sun radiation, they contribute towards preventing premature light-caused skin ageing and skin cancer.

In this connection a distinction is made between soluble organic UV filters and those based on mineral and / or organic pigments.
Whereas soluble organic UV filters absorb the UV radiation, transform it into heat and form an invisible protection shield in the upper skin layer, UV filters on the basis of pigments reflect, scatter and absorb the sun radiation already on the skin surface.

Organic UV filters absorb the energy of the ultraviolet part of the light in the range from approximately 280 to 400 nm.
In this connection the energy of the absorbed photon must correspond to the energy which is necessary to elevate the electron in the molecule of the filter substance from a low to a higher orbit.

When the electron falls back to its original orbit, the absorbed energy is either given off as heat or as radiation of a longer wavelength and hence rendered harmless.

The organic UV filters are distinguished, amongst others, by the position of the absorption area, the photostability, the solubility and the penetration capacity.
Depending on the wave range of the ultraviolet radiation which is absorbed by the UV filter, a distinction is made between UV-A, UV-B and broadband filters.



SCIENTIFIC FACTS OF NEO HELIOPAN E1000:
Neo Heliopan E1000, also referred to as Amiloxate, absorbs UV radiation which is an important cause of premature aging of the skin and in the development of melanoma and other forms of skin cancer.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN E1000:
CAS No.: 71617-10-2
EINECS: 275-702-5
UV-B absorber: oil soluble
Molecular Weight: 248.35 g/mol
INCI name: Isoamyl p-Methoxycinnamate
Chemical names: Isoamyl p-Methoxycinnamate
Isoamyl 2-(4-Methoxyphenyl)-2-Propenoate
Empirical Formula: C15H20O3
Assay (GLC) %: min. 98
Relative density (D20/4): 1.038 – 1.042
Refractive Index (n20/D): 1.556 – 1.560
Specific extinction E 1% ,
in methanol λ max. 307/308 nm: min 980

Solubility at 20°C in: Readily soluble in most cosmetic oils except glycols.
Shelf life and storage conditions: 30 months in the original,
unopened container, dry, at 5 to 40°C.
Appearance: Colorless to yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 362.00 to 363.00 °C @ 760.00 mm Hg (est)
Flash Point: 305.00 °F (151.60 °C) TCC (est)
logP (o/w): 4.393 (est)
Soluble in: Alcohol; Water, 4.858 mg/L @ 25 °C (est)
Insoluble in: Water
Molecular Weight: 248.32 g/mol
XLogP3-AA: 3.9
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3

Rotatable Bond Count: 7
Exact Mass: 248.14124450 g/mol
Monoisotopic Mass: 248.14124450 g/mol
Topological Polar Surface Area: 35.5 Ų
Heavy Atom Count: 18
Formal Charge: 0
Complexity: 263
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of NEO HELIOPAN E1000:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN E1000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN E1000:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN E1000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN E1000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN E1000:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan HMS is an effective, liquid UVB absorber.
Neo Heliopan HMS is effective UVB absorber with an UV absorbance of min. 170 at 305 nm for various applications.


CAS Number: 118-56-9
EC Number: 204-260-8
MDL Number: MFCD00019377
UV-B absorber: oil soluble
Molecular Weight: 262.2 g/mol
INCI name: Homosalate
USAN: Homosalate
Chemical names: 3,3,5-Trimethylcyclohexylsalicylate, Homomenthyl salicylate
Chemical Composition: 3,3,5-Trimethylcyclohexylsalicylate, Homomenthyl salicylate
Empirical Formula: C16H22O3



SYNONYMS:
Homomenthyl salicylateParsol® HMSNeo Heliopan HMSEusolex® HMSCoppertone3,3,5-Trimethylcyclohexyl SalicylateHomosalate, Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester, 3,3,5-Trimethylcyclohexanol Salicylate, 3,3,5-Trimethylcyclohexyl salicylate, Eusolex HMS, Filtrosol A, Heliopan, Heliopan HMS, Heliophan, Homomenthyl Salicylate, Kemester, Kemester HMS, NSC 164918, Neo Heliopan, Neo Heliopan HMS, Parsol HMS, Uniderm Homsal, Benzoic acid,2-hydroxy-,3,3,5-trimethylcyclohexyl ester, Salicylic acid,3,3,5-trimethylcyclohexyl ester, Cyclohexanol,3,3,5-trimethyl-,salicylate, Heliophan, Homosalate, 3,3,5-Trimethylcyclohexyl salicylate, Heliopan, Homomenthyl salicylate, Filtrosol A, Kemester, Neo Heliopan, Eusolex HMS, Kemester HMS, Neo Heliopan HMS, Heliopan HMS, Uniderm Homsal, NSC 164918, Parsol HMS, 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate, Escalol HMS, 8045-71-4, 50610-40-7, 52253-93-7, 194304-23-9, 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate, Homosalate, Homosalate, 118-56-9, Homomenthyl salicylate, Coppertone, 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE, Heliopan, Heliophan, Filtersol ''A'', 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate, m-Homomenthyl salicylate, Homosalatum, Homosalato, (3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate, Caswell No. 482B, Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester, 52253-93-7, CCRIS 4885, NSC 164918, Metahomomenthyl salicylate, Homosalatum [INN-Latin], Homosalato [INN-Spanish], Salicylic acid, m-homomenthyl ester, EINECS 204-260-8, 2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester, UNII-V06SV4M95S, Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester, EPA Pesticide Chemical Code 076603, NSC-164918, V06SV4M95S, MFCD00019377, Homosalate [USAN:USP], DTXSID1026241, EC 204-260-8, Salicylic acid, 3,3,5-trimethylcyclohexyl ester, NCGC00091888-01, Homosalatum (INN-Latin), Homosalato (INN-Spanish), HOMOSALATE (MART.), HOMOSALATE [MART.], HOMOSALATE (USP-RS), HOMOSALATE [USP-RS], Homosalate (USAN:USP), DTXCID606241, Salicylic acid, 3,3,5-trimethylcyclohexyl ester (8CI), HOMOSALATE (USP IMPURITY), HOMOSALATE [USP IMPURITY], HOMOSALATE (USP MONOGRAPH), HOMOSALATE [USP MONOGRAPH], Filtrosol A, component of Coppertone, SR-05000001884, Homosalate, Kemester HMS, CAS-118-56-9, Homosalate; Salicylic acid 3,3,5-trimethylcyclohexyl ester; 3,3,5-Trimethylcyclohexyl salicylate, Filtersol''A'', HOMOSALATE [MI], Homosalate (USP/INN), HOMOSALATE [INN], Prestwick1_001090, Prestwick2_001090, Prestwick3_001090, HOMOSALATE [USAN], HOMOSALATE [WHO-DD], SCHEMBL16207, BSPBio_001140, SPECTRUM1505020, SPBio_003030, BPBio1_001254, Sun Protection Facial SPF 50, CHEMBL1377575, CHEBI:91642, 3,5-Trimethylcyclohexyl salicylate, HMS1571I22, HMS2093G22, HMS2098I22, HMS3715I22, Pharmakon1600-01505020, >98.0%,mixture of cis and trans, component of Coppertone (Salt/Mix), HY-B0928, 3,3,5-Trimethylcyclohexylsalicylate, Tox21_111174, Tox21_202109, Tox21_303082, NSC164918, NSC758908, s4572, AKOS015904082, Tox21_111174_1, 1ST3404, CCG-213330, DB11064, NSC-758908, NCGC00091888-02, NCGC00091888-03, NCGC00091888-04, NCGC00091888-05, NCGC00091888-06, NCGC00091888-09, NCGC00257063-01, NCGC00259658-01, AS-10409, DA-54062, SY051923, SBI-0206787.P001, AB00514041, NS00009551, Salicylic acid,3,5-trimethylcyclohexyl ester, T2278, Benzoic acid, 3,3,5-trimethylcyclohexyl ester, D04450, E78223, AB00514041_02, EN300-7381967, A921433, J-519754, Q2260189, SR-05000001884-1, SR-05000001884-2, BRD-A34751532-001-03-6, BRD-A34751532-001-04-4, BRD-A34751532-001-06-9, 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester, Homosalate, United States Pharmacopeia (USP) Reference Standard, Homosalate, Pharmaceutical Secondary Standard; Certified Reference Material



Neo Heliopan HMS is oil-soluble.
Neo Heliopan HMS is effective UVB absorber with an UV absorbance of min. 170 at 305 nm for various applications.
Neo Heliopan HMS is effective solubilizer for crystalline UV absorbers such as Neo Heliopan 357, BMT, BB, MBC as well as Ethylhexyl Triazone, Diethylhexyl Butamido Triazone and Diethylamino Hydroxybenzoyl Hexyl Benzoate.


Neo Heliopan HMS is suitable Vegan according to Symrise policy.
Neo Heliopan HMS is halal & Kosher status available on request.
Neo Heliopan HMS is an effective, liquid UVB absorber.


Neo Heliopan HMS is an effective solubilizer for crystalline UV absorbers.
Neo Heliopan HMS is oil soluble and can therefore be used in water-resistant sunscreens.
Neo Heliopan HMS is a condition at 20°C clear, colorless to light yellow liquid


Neo Heliopan HMS has slight minty odor (comparable to standard)
Neo Heliopan HMS appears as viscous or light yellow to slightly tan liquid or oil.
Neo Heliopan HMS is a benzoate ester and a member of phenols.


Neo Heliopan HMS derives from a salicylic acid.
Neo Heliopan HMS is an organic compound that belongs to salicylates.
Neo Heliopan HMS is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol.


Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light.
Neo Heliopan HMS specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Neo Heliopan HMS is a common ingredient in many commercially available sunscreens.


There are no reported adverse effects from Neo Heliopan HMS.
Neo Heliopan HMS is a colorless liquid oil-soluble phenolic compound, an effective UVB filter (in a range of 295 to 315 nm wavelength), and solubilizer for other UV absorbers (including solid filters) enhancing the entire SPF of the formulation.


Neo Heliopan HMS is an ester of Homomenthol (3,3,5-trimethylcyclohexanol) with salicylic acid.
Neo Heliopan HMS is a liquid.
Neo Heliopan HMS is a homolog of menthyl salicylate.


Neo Heliopan HMS is viscous or light yellow to slightly tan liquid or oil.
Neo Heliopan HMS appears as viscous or light yellow to slightly tan liquid or oil.
Neo Heliopan HMS is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.


Neo Heliopan HMS is an organic compound used in some sunscreens.
Neo Heliopan HMS is made by the Fischer–Speier esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, the latter being a hydrogenated derivative of isophorone.


Contained in 45% of U.S. sunscreens, Neo Heliopan HMS is used as a chemical UV filter.
The salicylic acid portion of the molecule absorbs ultraviolet rays with a wavelength from 295 nm to 315 nm, protecting the skin from sun damage.
The hydrophobic trimethyl cyclohexyl group provides greasiness that prevents Neo Heliopan HMS from dissolving in water.


Neo Heliopan HMS appears as viscous or light yellow to slightly tan liquid or oil.
Neo Heliopan HMS is a benzoate ester and a member of phenols.
Neo Heliopan HMS is functionally related to a salicylic acid.


Neo Heliopan HMS is an organic compound that belongs to salicylates.
Neo Heliopan HMS is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol.
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light.


Neo Heliopan HMS specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Neo Heliopan HMS is a common ingredient in many commercially available sunscreens.
There are no reported adverse effects from Neo Heliopan HMS.
Neo Heliopan HMS is a natural product found in Camellia sinensis with data available.



USES and APPLICATIONS of NEO HELIOPAN HMS:
Application of Neo Heliopan HMS: sun care cosmetics, skin care, lip car.
Neo Heliopan HMS is a very good oil soluable sunscreen for sun care cosmetics.
Neo Heliopan HMS is widely used for all kinds of formulation.


Neo Heliopan HMS is an effective oil-soluble liquid UV-B absorber.
Neo Heliopan HMS is an excellent solubilizer for crystalline UV absorbers such as Avobezone or Ethylhexyl Triazone.
Neo Heliopan HMS is a high-performance sunscreen that offers broad-spectrum protection against UVA and UVB rays.


Neo Heliopan HMS's advanced formula is non-greasy, lightweight, and suitable for all skin types.
Neo Heliopan HMS is water-resistant and provides long-lasting protection for extended periods of time.
Neo Heliopan HMS is perfect for daily use to keep your skin safe from sun damage.


Neo Heliopan HMS acts as an effective UVB absorber.
Neo Heliopan HMS can be used in water-resistance sunscreens.
Neo Heliopan HMS is also an effective solubilizer for crystalline UV absorbers.


Neo Heliopan HMS acts as an effective UVB absorber with a UV absorbance (E 1%/1cm) of min. 170 at 305nm for various applications.
Neo Heliopan HMS is used for products with low and – in combination with other UV filters – high sun protection factors.
Neo Heliopan HMS is also an effective solubilizer for crystalline UV absorbers.


Neo Heliopan HMS can be used in water-resistance sunscreens.
Protecting skin from the UVB spectrum of damaging radiation, Neo Heliopan HMS minimizes the short- and long-term harmful effects of sun exposure.
Neo Heliopan HMS is a worldwide approved filter for sunscreens that can be combined with a wide range of liquid and solid filters.


Without reported adverse effects, Neo Heliopan HMS is one of the most popular and safe UV filters used in water-resistant sunscreens.
Neo Heliopan HMS is an effective UVB absorber with a UV absorbance (E 1% / 1cm) of min. 170 at 305nm for various applications.
Neo Heliopan HMS is used for products with low and – in combinations with other UV filters – high sun protection factors.


Neo Heliopan HMS is an effective solubilizer for crystalline UV absorbers.
Neo Heliopan HMS is oil soluble and can therefore be used in water-resistant sunscreens.
Neo Heliopan HMS is approved worldwide.


Concentration maximum of Neo Heliopan HMS varies according to local legislation.
Neo Heliopan HMS is a safe and effective UVB absorber.
Application/Recommended for: Neo Heliopan HMS is used Sun care (Sun protection, After-sun & Self-tanning)>Sun protection.
Recommended use levels of Neo Heliopan HMS: Approved world-wide and concentration maximum varies according to local legislation.



FUNCTIONS OF NEO HELIOPAN HMS:
*UV filters
*UV absorber
*Sunscreen
*Fragrance



CLAIMS OF NEO HELIOPAN HMS:
*Sunscreen Agents > UV Filters / Sunscreens
*UVB Absorber



THE BENEFITS OF NEO HELIOPAN HMS:
• Neo Heliopan HMS is an effective UVB absorber with an UV absorbance (E 1% ) of min. 170 at 305 nm for various applications.
• Neo Heliopan HMS is used for products with low and – in combination with other UV filters – high sun protection factors.
• Neo Heliopan HMS is easily to incorporate into emulsions and suitable for a wide variety of cosmetic applications.
• Cold processing of sunscreen products possible.
• Neo Heliopan HMS is an effective solubilizer for crystalline UV absorbers such as Neo Heliopan 357, BMT, BB, MBC as well as Ethylhexyl Triazone, Diethylhexyl Butamido Triazone and Diethylamino Hydroxybenzoyl Hexyl Benzoate.
• Neo Heliopan HMS is oil soluble and can therefore be used in water-resistant sunscreens.
• Neo Heliopan HMS is approved world-wide.
• Concentration maximum of Neo Heliopan HMS varies according to local legislation.
• Neo Heliopan HMS is a safe and effective UVB absorber.



REACTIVITY PROFILE OF NEO HELIOPAN HMS:
An ester and a phenol.
Esters react with acids to liberate heat along with alcohols and acids.
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions.
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN HMS:
CAS No.: 118-56-9
EINECS: 204-260-8
UV-B absorber: oil soluble
Molecular Weight: 262.2 g/mol
INCI name: Homosalate
USAN: Homosalate
Chemical names: 3,3,5-Trimethylcyclohexylsalicylate, Homomenthyl salicylate
Empirical Formula: C16H22O3
Relative density (D25/25): 1.049 – 1.053
Relative density (D20/4): 1.050 – 1.053
Refractive Index (n20/D): 1.516 – 1.519
Specific extinction E 1% , in methanol λ max. 305 nm: 170 – 180

Solubility at 20°C in: Readily soluble in most cosmetic oils except glycols.
Shelf life and storage conditions: 36 months in the original,
unopened container, dry, at 5 to 40°C.
Chemical Information:
CAS Number: 118-56-9
Molecular Formula: C16H22O3
Molecular Weight: 262.34 g/mol
Exact Mass: 262.34 g/mol
EC Number: 204-260-8
UNII: V06SV4M95S
NSC Number: 758908, 164918
DSSTox ID: DTXSID1026241
HS Code: 29182300

Physical Characteristics:
Appearance: Colorless transparent liquid; 3,3,5-trimethylcyclohexylsalicylate
appears as a viscous or light yellow to slightly tan liquid or oil.
Density: 1.045-1.048 g/cm³ @ 25 °C
Boiling Point: 163 °C
Flash Point: 169 - 173 °C
Refractive Index: n20 1.516 to 1.518
Water Solubility: Vapor Pressure: 4.17E-05 mmHg at 25 °C
Melting Point: < -20 °C
Solubility in Water: 0.4 mg/L
Chemical Properties:
PSA (Polar Surface Area): 46.5 Ų
XLogP3: 5

Reactive Group: Esters, Sulfate Esters, Phosphate Esters,
Thiophosphate Esters, and Borate Esters
Hazards:
Flash Point: 171 °C (340 °F; 444 K)
Storage:
Storage Condition: Light-resistant container
Air and Water Reactions:
This compound will hydrolyze under basic conditions.
Insoluble in water.
Molecular Properties:
Molecular Weight: 262.34 g/mol
Exact Mass: 262.15689456 g/mol
Monoisotopic Mass: 262.15689456 g/mol
XLogP3-AA: 5

Topological Polar Surface Area (PSA): 46.5 Ų
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 3
Heavy Atom Count: 19
Formal Charge: 0
Complexity: 324
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of NEO HELIOPAN HMS:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN HMS:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN HMS:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN HMS:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN HMS:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN HMS:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan Hydro offers very good stability and UV protection.
Neo Heliopan Hydro is suitable for water-based transparent sunscreen products such as gels or clear sprays.


CAS Number: 27503-81-7
EC Number: 248-502-0
UV-B absorber: water soluble
Molecular Weight: 274.3 g/mol
INCI name: Phenylbenzimidazole Sulfonic Acid
USAN: Ensulizole
Chemical Composition: 2-Phenylbenzimidazole-5-sulfonic acid
Chemical names: 2-Phenylbenzimidazole-5-sulfonic acid
Empirical Formula: C13H10N2O3S



SYNONYMS:
2-phenyl-1H-benzimidazol-5-sulfonic acid, 2-Phenylbenzimidazole-5-sulfonic acid, Ensulizole, 2-Phenyl-5-sulfobenzimidazole, Phenylbenzimidazolesulfonic acid,2-Phenyl-1H-Benzimidazole-5-sulfonic acid, Eusolex 232, 2-Phenyl-5-Benzimidazolesulfonic acid, Neo Heliopan Hydro, Parsol HS, Novantisol



Neo Heliopan Hydro acts as a highly effective UVB absorber.
Neo Heliopan Hydro offers very good stability and UV protection.
Neo Heliopan Hydro exhibits very good photostability and safety profile.


It is the recommended pH value for finished products containing Neo Heliopan Hydro: 7.0 to 7.5 for TEA, NaOH, KOH and > 6.0 for L-Arginine.
Neo Heliopan Hydro is suitable for water-based transparent sunscreen products such as gels or clear sprays.
Neo Heliopan Hydro is water-soluble.


Neo Heliopan Hydro is highly effective UVB absorber with an UV absorbance of min. 920 at around 302 nm which forms water-soluble salts with the addition of a base.
Neo Heliopan Hydro is practically odorless, excellent stability, compatible with other ingredients and packaging.


Neo Heliopan Hydro is excellent photostability and safety profile.
Neo Heliopan Hydro is very suitable for water-based transparent sunscreen products such as gels or sprays as well as for creams and lotions.
Neo Heliopan Hydro is a highly effective water-soluble UVB absorber with a UV absorbance (E 1%/1cm) of min. 920 at around 302nm which forms water soluble salts with the addition of a base.


Neo Heliopan Hydro acts as a highly effective UVB absorber.
Neo Heliopan Hydro is a condition at 20°C white to light beige powder.
Neo Heliopan Hydro is neutral (comparable to standard).


Neo Heliopan Hydro is water-soluble
Neo Heliopan Hydro is highly effective UVB absorber with an UV absorbance of min. 920 at around 302 nm which forms water-soluble salts with the addition of a base.


Neo Heliopan Hydro is practically odorless, excellent stability, compatible with other ingredients and packaging.
Neo Heliopan Hydro is excellent photostability and safety profile.
Neo Heliopan Hydro is halal & Kosher status available on request.



USES and APPLICATIONS of NEO HELIOPAN HYDRO:
Neo Heliopan Hydro is very suitable for water-based transparent sunscreen products such as gels or sprays as well as for creams and lotions.
Neo Heliopan Hydro is suitable Vegan according to Symrise policy.
Neo Heliopan Hydro offers very good stability and compatible with other ingredients and packaging.


Neo Heliopan Hydro exhibits very good photostability and safety profile.
Neo Heliopan Hydro provides synergistic effects with oil soluble UV filters.
Neo Heliopan Hydro is suitable for water-based transparent sunscreen products such as gels or clear sprays as well as for creams and lotions.



CLAIMS OF NEO HELIOPAN HYDRO:
*Sunscreen Agents > UV Filters / Sunscreens
*UVB Absorber



PREPARATION OF NEUTRALIZED AQUEOUS SOLUTIONS OF NEO HELIOPAN HYDRO:
Mix approx. two thirds of the neutralization agent with water and add Neo Heliopan Hydro.
Disperse the Neo Heliopan Hydro while stirring.
Neutralize the dispersion up to the needed pH value while stirring thoroughly.

At the end of the neutralizing process add the base slowly, as solubilizing of residual Neo Heliopan Hydro may
take some time.
The neutralized solution must be nearly clear.
Add the rest of needed water for the final percentage, stir until homogeneous.

*In the final formulation, the pH value preventing recrystallization of Neo Heliopan Hydro vary with the used
neutralization agent:
Biotive® L- Arginine: 6.2 – 6.8
Triethanolamine: 7.0 – 7.8
Sodium Hydroxide: 7.0 – 7.8



THE BENEFITS OF NEO HELIOPAN HYDRO:
• Neo Heliopan Hydro is a highly effective UVB absorber with an UV absorbance (E 1% ) of min. 920 at around 302 nm which forms water soluble salts with the addition of a base.
• Neo Heliopan Hydro is practically odorless, has an excellent stability and is compatible with other ingredients and packaging.
• Neo Heliopan Hydro has an excellent photostability and safety profile.
• A large SPF increase could be reached by combining Hydro with oil soluble UV filters in sunscreen products.
Only a minimum of concentration of these combinations is necessary to achieve the desired SPF.
• Neo Heliopan Hydro is very suitable for water-based transparent sunscreen products such as gels or sprays.
• Neo Heliopan Hydro is possible to formulate waterproof sunscreen products with Hydro.
• Recommended pH value for finished products containing Neo Heliopan Hydro: 7.0 to 7.5 for TEA, NaOH, KOH
and > 6.0 for L-Arginine.
• Neo Heliopan Hydro is approved world-wide.
Concentration maximum varies according to local legislation.
• Neo Heliopan Hydro is a safe and effective UVB absorber.



IMPORTANT ADVICE OF NEO HELIOPAN HYDRO FOR FORMULATIONS:
Neo Heliopan Hydro is a fine crystalline powder.
The water solubility of the free acid is extremely small.
By the addition of a base such as sodium hydroxide or triethanolamine water soluble salts will be formed.

In general formulations containing Neo Heliopan Hydro should have a pH-value between 7.2 and 7.5 when neutralized with sodium hydroxide, triethanolamine
and potassium hydroxide as at pH values below 7.
Neo Heliopan Hydro may revert to its acid form and crystallization could result.

A pH value > 6.0 is possible if L-Arginine is used as neutralization agent.
Neo Heliopan Hydro can be added non-neutralized to the aqueous phase of the formulation, addition of a neutralization base with vigorous stirring will form the salt which then dissolves into the aqueous phase.
Neo Heliopan Hydro can be also added as aqueous pre-mix.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN HYDRO:
CAS No.: 27503-81-7
EINECS: 248-502-0
UV-B absorber: water soluble
Molecular Weight: 274.3 g/mol
INCI name: Phenylbenzimidazole Sulfonic Acid
USAN: Ensulizole
Chemical names: 2-Phenylbenzimidazole-5-sulfonic acid
Empirical Formula: C13H10N2O3S
Assay (USP/NF) %: 98 – 102
Loss on drying %: max. 2
Melting point °C: >300

Specific extinction E 1%
1cm ,in water
as sodium salt at λ max. 302 nm: 920 – 990
Solubility of Neo Heliopan® Hydro as
sodium or triethanolamine salt at 20°C in: Ethanol / Isopropanol miscible
Water < 30%
Water / Ethanol (10 -50%) < 20%
Water / Isopropanol (10 – 50%) < 20%
not soluble in oil
Shelf life and storage conditions: 36 months in the original,
unopened container, dry, at 5 to 40°C.
Molecular form: C13H10N2O3S

Appearance: NA
Mol. Weight: 274.3
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: NA
Molecular Formula: C13H10N2O3S
Molecular Weight: 274.30
CAS Registry Number: 27503-81-7
CAS Name: 2-Phenyl-1H-benzimidazole-5-sulfonic acid
Additional Names: phenylbenzimidazole sulfonic acid
INCI Names: PHENYLBENZIMIDAZOLE SULFONIC ACID
Chemical Composition: 2-Phenylbenzimidazole-5-sulfonic acid



FIRST AID MEASURES of NEO HELIOPAN HYDRO:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN HYDRO:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.




FIRE FIGHTING MEASURES of NEO HELIOPAN HYDRO:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.




EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN HYDRO:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN HYDRO:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN HYDRO:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

Neo Heliopan MBC offers improved photostability.
Neo Heliopan MBC is a condition at 20°C pale white to white crystals


CAS Number: 36861-47-9
EC Number: 253-242-6
MDL Number: MFCD00209662
UV-B absorber: oil soluble
Molecular Weight: 254.4 g/mol
INCI name: 4-Methylbenzylidene Camphor
Chemical names: 3-(4’-Methyl) benzylidene-bornan-2-one
Chemical Composition: 3-(4-methylbenzylidene)-d-1-camphor
Empirical Formula: C18H22O



SYNONYMS:
Neo Heliopan?MBC, MBC 95, 4'-Methylbenzylidene camphor, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-Bicyclo[2.2.1]heptan-2-one, 4-METHYLBENZYLIDENE CAMPHOR, 3-(4-METHYLBENZYLIDENE)CAMPHOR, 3-(4'-METHYL)BENZYLIDENE-BORNAN-2-ONE, 3-(4-METHYLZYLIDENE)-BRONAN-2-ONE, 3-(4-METHYLZYLIDENE)CAMPHOR, (3e)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, EUSOLEX(R) 6300, 4-Methylbenzylidenecamphor, 3-(4-methylbenzylidene)-d-camphor, (3Z)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, (1S,3E,4S)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, (1R,3E,4R)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-(p-tolylmethylene)norbornan-2-one, 3-(4-Methylbenzylidene)-DL-camphor, 4”-METHYLBENZYLIDENE CAMPHOR(MBC 95), NEO-HELIOPAN, METHYLBENZYLIDENECAMPHOR, MEXORYLSD, 3-(4-METHYLBENZYLIDINE)CAMPHOR, (+-)-1,7,7-Trimethyl-3-[(4-methylphenyl)methylene] bicyclo[2.2.1]heptan-2-one, Contralum 6300, Zinc01481820, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-bicyclo[2.2.1]heptan-2-one, 4-mbc, enzacamene, eusolex 6300, neo heliopan mbc, parsol 500, uvinul mbc 95, 3-(4-Methylbenzylidene)camphor, 4-MBC, Enzacamene, Uvinul MBC 95, Parsol 500, Neo Heliopan MBC, Eusolex 6300, Enzacamene, Eusolex 6300, 4-MBC, Neo Heliopan MBC, Parsol 500, Uvinul MBC 95, MBC 95, MEXORYLSD, NEO-HELIOPAN, EUSOLEX(R) 6300, Neo Heliopan?MBC, METHYLBENZYLIDENECAMPHOR, 4-Methylbenzylidencamphor, 3-(4-METHYLZYLIDENE)CAMPHOR, 4-METHYLBENZYLIDENE CAMPHOR, 4'-Methylbenzylidene camphor, 3-(4-METHYLBENZYLIDEN)CAMPHOR, 3-(4-METHYLBENZYLIDINE)CAMPHOR, 3-(4-Methylbenzylidene)-camphor, 3-(4-mythylbenzylidene)-d-camphor, 3-(4-METHYLZYLIDENE)-BRONAN-2-ONE, 3-(4-Methylbenzylidene)-DL-camphor, 4''-METHYLBENZYLIDENE CAMPHOR(MBC 95), 3-(4'-METHYL)BENZYLIDENE-BORNAN-2-ONE, 1,7,7-trimethyl-3-(p-tolylmethylene)norbornan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-Bicyclo[2.2.1]heptan-2-one, (+-)-1,7,7-Trimethyl-3-[(4-methylphenyl)methylen]bicyclo[2.2.1]heptan-2-on, (2Z)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one, (3e)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, (3Z)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, (1S,2Z,4R)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]-3-bicyclo[2.2.1]heptanone, (1S,3E,4S)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, (1R,3E,4R)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, 4-Methylbenzylidene camphor, 36861-47-9, Enzacamene, 4-Methylbenzylidenecamphor, 3-(4-Methylbenzylidene)camphor, 3-(4'-Methylbenzylidene)camphor, Enzacamene D-L form, 1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one, METHYL BENZYLIDENE CAMPHOR, Methyl Benzylidene Camphor; 3-(4'-Methyl)benzylidene-bornan-2-one, 3-(4'-methyl)benzylidene-bornan-2-one, CHEMBL4297074, 38102-62-4, DA-30146, NS00009412, 4-Methylbenzylidene Camphor, 3-(4-Methylbenzylidene)-2-bornanone, Enzacamene



Neo Heliopan MBC is a highly effective oil-soluble UVB absorber and has additional absorption in the short-wave UVA spectrum.
Neo Heliopan MBC acts as a highly effective UVB absorber.
Neo Heliopan MBC exhibits additional absorption in the short-wave UVA spectrum.


Neo Heliopan MBC offers improved photostability.
Neo Heliopan MBC is a condition at 20°C pale white to white crystals
Neo Heliopan MBC has slight odor, no effect on the finished product (comparable to standard)


Neo Heliopan MBC is oil-soluble
Neo Heliopan MBC is highly effective UVB absorber with a specific extinction of min. 930 at around 299 nm in methanol and has additional absorption in the shorter UVA-II range (320 to 340 nm)


Neo Heliopan MBC can improve the photostability of Butyl Methoxydibenzoylmethane
Neo Heliopan MBC is suitable Vegan according to Symrise policy
Neo Heliopan MBC is halal & Kosher status available on request


Neo Heliopan MBC is a highly effective oil-soluble UVB absorber and has additional absorption in the short-wave UVA spectrum.
Neo Heliopan MBC is oil soluble UV-B absorber, which can increase SPF value with only a small amount of addition, is an effective light stabilizer of Parsol 1789.


Neo Heliopan MBC is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities, binding competitively to estrogen receptors and stimulating transactivation; changes reproductive organ and brain development in both males and females
Neo Heliopan MBC is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.


Neo Heliopan MBC is a chemical sunscreen agent that protects in the UVB range (290-320 nm) with a peak absorbance at 301 nm.
Neo Heliopan MBC is an oil-soluble powder that is slightly photo-unstable (it takes 65 minutes to lose 10% of its protecting power and 345 minutes to lose half of it), but it can still help to stabilize the famously unstable UVA filter, avobenzone.


Neo Heliopan MBC is called Cosroma FSJ003.
Neo Heliopan MBC is a chemical sunscreen agent that protects in the UVB range (290-320 nm) with a peak absorbance at 301 nm.


Neo Heliopan MBC is an oil-soluble powder that is slightly photo-unstable (it takes 65 minutes to lose 10% of its protecting power and 345 minutes to lose half of it).
Neo Heliopan MBC is a white powder that is practically odorless and readily soluble in the usual cosmetic oils.


Neo Heliopan MBC is a UV-B filter with a high absorptivity that is approved in the EU for use in all the main types of sun protection products (O/W and W/O emulsions, gels, and aerosols).
Neo Heliopan MBC is stable to light and capable of stabilizing butylmethoxy-dibenzoylmethane.



USES and APPLICATIONS of NEO HELIOPAN MBC:
Neo Heliopan MBC is used in sun protection products.
Commonly known as Neo Heliopan MBC, enzacamene is a camphor derivative and an organic chemical UV-B filter.
Neo Heliopan MBC is used in cosmetic products such as sunscreen to provide skin protection against UV rays.


Neo Heliopan MBC is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
As such, Neo Heliopan MBC is used in sunscreen lotions and other skincare products claiming a SPF value.


Neo Heliopan MBC is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.
Neo Heliopan MBC is for scientific research only and shall not be used for other purposes.


Since the estrogen receptor (ER) ligand type can influence transactivation, Neo Heliopan MBC is important to obtain information on molecular actions of nonclassical ER agonists.
Neo Heliopan MBC is a highly effective oil-soluble UVB absorber and has additional absorption in the short-wave UVA spectrum.



THE BENEFITS OF NEO HELIOPAN MBC:
• Neo Heliopan MBC is a highly effective UVB absorber with a specific extinction (E 1% ) of min. 930 at around 299 nm in Methanol and has additional absorption in the shorter UV-A II range (320 to 340 nm).
• Neo Heliopan MBC is oil soluble and has a faint odor which has no effect on the finished product.
• Neo Heliopan MBC is an oil soluble, white crystalline powder.
• Adequate solubility in the formulation must be ensured in order to avoid recrystallization of the Neo Heliopan MBC.
• The UV filters Neo Heliopan AV, E1000, 303, OS, HMS and certain emollients are excellent solvents.
• Neo Heliopan MBC is an excellent absorber for UV-broadband protection and also for water resistant products.
• Neo Heliopan MBC can improve the in vitro photostability of Butyl Methoxydibenzoylmethane.
• The absorber, Neo Heliopan MBC, is excellent compatible with cosmetic ingredients and easily to incorporate into emulsions; cold processing is possible.
• Neo Heliopan MBC is approved up to 4% in: Europe, Australia, Mercosur, South Africa, China, Taiwan, South Korea and the ASEAN states (further information under the legislation part page 08/09).
• Neo Heliopan MBC is a safe and effective UVB absorber.



FUNCTIONS OF NEO HELIOPAN MBC IN COSMETICS PRODUCTS:
*LIGHT STABILIZER
Neo Heliopan MBC is protecting the cosmetic product from deterioration effects of light

*UV ABSORBER
Neo Heliopan MBC protects the cosmetic product from damage caused by UV light

*UV FILTER
Neo Heliopan MBC protects skin or hair from harmful UV radiation



ORIGIN OF NEO HELIOPAN MBC:
Origin
Neo Heliopan MBC is a synthetic/plant



OCCURRENCE OF NEO HELIOPAN MBC IN COSMETICS:
As a UV filter in sunscreens and other cosmetics with UV protection (care products, decorative cosmetics)



BACKGROUND INFORMATION OF NEO HELIOPAN MBC ON USE IN COSMETICS:
Neo Heliopan MBC is a soluble organic UV-B filter.
Neo Heliopan MBC absorbs UV-B radiation from approximately 280 to 320 nm.
The maximum concentration of Neo Heliopan MBC is 4 %.



CLAIMS OF NEO HELIOPAN MBC:
*Sunscreen Agents > UV Filters / Sunscreens absorption
*UVB Absorber



FUNCTIONS OF NEO HELIOPAN MBC:
*Light Stabilizer
*UV absorber
*UV filters



MECHANISM OF NEO HELIOPAN MBC:
All the camphor-derived sunscreens dissipate the photon energy by cis-trans isomerisation.
However, for Neo Heliopan MBC the quantum yield for this isomerization is only between 0.13-0.3.
This low quantum yield means that other photochemical processes are also occurring.



PHYSICAL and CHEMICAL PROPERTIES of NEO HELIOPAN MBC:
CAS No.: 36861-47-9
EINECS: 253-242-6
UV-B absorber: oil soluble
Molecular Weight: 254.4 g/mol
INCI name: 4-Methylbenzylidene Camphor
Chemical names: 3-(4’-Methyl) benzylidene-bornan-2-one
Empirical Formula: C18H22O
Assay (GLC) %: min. 99.5
Camphor (GLC) %: max. 0.02
4-Methylbenzaldehyd (GLC) %: max. 0.1
Melting point °C: min. 66
Specific extinction E 1% ,
in methanol λ max. 299 nm: min 930

Shelf life and storage conditions: 36 months in the original,
unopened container, dry, at 10 to 30°C.
Formal Name: 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-bicyclo[2.2.1]heptan-2-one
CAS Number: 36861-47-9
Molecular Formula: C18H22O
Formula Weight: 254.4
Purity: ≥98%
Formulation: A crystalline solid
Solubility:
DMF: 30 mg/ml
DMSO: 20 mg/ml
Ethanol: 30 mg/ml
Ethanol (pH 7.2)(1:2): 0.3 mg/ml

λmax: 226, 299 nm
SMILES: CC1=CC=C(/C=C2[C@H]3CCC@@(C3(C)C)C/2=O)C=C1
InChi Code: InChI=1S/C18H22O/c1-12-5-7-13(8-6-12)11-14-15-9-10-18(4,16(14)19)17(15,2)3/h5-8,11,15H,9-10H2,1-4H3/b14-11-/t15-,18-/m1/s1
InChi Key: HEOCBCNFKCOKBX-SSEPWQBHSA-N
Name: (2E)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one
Other (deleted CASRN): 38102-62-4
ECHA EINECS - REACH Pre-Reg: 253-242-6
FDA UNII: 8I3XWY40L9
Beilstein Number: 9213949
XlogP3-AA: 4.50 (est)
Molecular Weight: 254.37254000

Appearance: White powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 371.00 to 372.00 °C @ 760.00 mm Hg (est)
Flash Point: 336.00 °F (168.90 °C) (est)
logP (o/w): 3.385 (est)
Soluble in: Alcohol
Water Solubility: 0.1966 mg/L @ 25 °C (est)
Insoluble in: Water
CAS No.: 36861-47-9

Item No.: A106890
Molecular Formula: C18H22O
Molecular Weight: 254.37 g/mol
Purity: 98%
MDL No.: MFCD00209662
Physical Properties:
Density: 1.064 ± 0.06 g/cm³ (Predicted)
Melting Point: 66-68°C
Boiling Point: 198-200°C (371.9°C at 760 mmHg)
Flash Point: 168.9°C

Refractive Index: 1.583
Vapor Pressure: 9.99E-06 mmHg at 25°C
Solubility:
Powder: Inert atmosphere, Room Temperature
Liquid: -20°C: 3-6 months; -80°C: 12 months
Chemical Identifiers:
InChI: InChI=1/C18H22O/c1-12-5-7-13(8-6-12)11-14-15-9-10-18(4,16(14)19)17(15,2)3/h5-8,11,15H,9-10H2,1-4H3
BRN: 9213949
EINECS: 253-242-6
Molecular Properties:
XLogP3-AA: 4.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1

Rotatable Bond Count: 1
Exact Mass: 254.167065321 g/mol
Monoisotopic Mass: 254.167065321 g/mol
Topological Polar Surface Area: 17.1 Ų
Heavy Atom Count: 19
Formal Charge: 0
Complexity: 423
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 1
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



FIRST AID MEASURES of NEO HELIOPAN MBC:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available



ACCIDENTAL RELEASE MEASURES of NEO HELIOPAN MBC:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of NEO HELIOPAN MBC:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of NEO HELIOPAN MBC:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of NEO HELIOPAN MBC:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of NEO HELIOPAN MBC:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available